Q:

Postgres change Encoding SQL_ASCII to UTF8

i want to change database encoding sql ascii to utf8 without drop database it is possible? (psql 9.5)
(I'm afraid of data disruption)
I'm trying this but doesn't work
 update pg_database set encoding = pg_char_to_encoding('utf8') where datname = 'name'

A:

You don't have to necessarily drop the database. However, you will need to effectively create another one with the new encoding, so changing the encoding really isn't possible to do without data disruption.
In general, the preferred method is to use pg_dump to dump the current database, create a new database with utf8 encoding, and do a pg_restore to that database.
However, along the way, you may find that there are data-related problems that must be fixed in order for the pg_restore to not fail, as there can                         G_PARAM_CONSTRUCT_ONLY |
	                                                          G_PARAM_STATIC_STRINGS));
}

/**
 * gedit_window_activatable_activate:
 * @activatable: A #GeditWindowActivatable.
 *
 * Activates the extension on the window property.
 */
void
gedit_window_activatable_activate (GeditWindowActivatable *activatable)
{
	GeditWindowActivatableInterface *iface;

	g_return_if_fail (GEDIT_IS_WINDOW_ACTIVATABLE (activatable));

	iface = GEDIT_WINDOW_ACTIVATABLE_GET_IFACE (activatable);
	if (iface->activate != NULL)
	{
		iface->activate (activatable);
	}
}

/**
 * gedit_window_activatable_deactivate:
 * @activatable: A #GeditWindowActivatable.
 *
 * Deactivates the extension on the window property.


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LAZY-HANDS® by Kernelope Enterprises was created by Colorado
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Digital Transformation is the process of updating your business and IT infrastructure to align with today's and tomorrow's consumers. Today that is important, but hard to do. Mobile consumer behaviors are changing far faster than most IT budgets and initiatives and that can cause problems. If your customers are adopting technologies and changing their path-to-purchase journeys at a pace that is faster than you can deliver, then you are opening up an opportunity gap for a more nimble competitor.

The multi-trillion economic opportunity around the "Internet of Things" (IoT) is emerging as the hottest topic for investors in 2015. As we connect the physical world with information technology, data from actions, processes andHow To:

Tune a Guitar

Loading audio... Loading audio...

A Sad Guitar. Take a second and strum the guitar. It doesn’t sound so good, does it? We’ve just taken it out of storage and it’s all out of tune...

Electric Tuner to the Rescue. Tune the guitar using the tuner. Click and drag the tuning knobs on the right to tighten and loosen the strings.

Keep at it. This doesn’t sound in tune quite yet. Scroll back up and try to get all of the tuning knobs to turn green.

How does this thing work? Guitars generate noise through the vibration of their strings. On an electric guitar such as this one, magnetic “pick-ups” convert those vibrations into an electrical signal which can then be sent to a tuner or an amplifier. This signal


can be visualized as a raw waveform, but often we want to visualize the frequency instead. The fourier transform is a mathematical function that reveals the audio frequencies hidden in that wave. Strum the guitar to see the frequency visualized.

Tuning by Ear. Now that we’ve tuned the guitar using a tuner, let’s try to tune the guitar by ear. This is more challenging, and it may take you time to master.

The guitar is out of tune again!

Match the Reference. We’ll start by tuning to a reference note. When you manipulate the tuners on the right the current note will be played, as will a reference note. Turn distortion off. This will be easier with a cleaner sound. Match the two sounds to get the guitar in tune.

Tuning Techniques.Grace form a perfect fourth. Learning to hear these intervals will help you tune your guitar without a tuner. Find the beat. When two strings are played together, they produce a third higher frequency known as an overtone. When the two strings are not perfectly in tune, the overtone is inconsistent over time. This produces a wobbling, a beat, in the overtone which you can hear if you listen carefully. Play notes with a 5.00 Hz difference: Listen for the beats! Turn distortion off. As you get a pair of strings closer in tune, the beats will slow down until the overtone is perfectly amplified. Listening for the slowing of these beats is a helpful cue for tuning.


Vatican has said he hopes to use the meetings to make a “fundamental step forward” in ridding the church of abuse.

Cruz, for his part, has said he will tell Francis he needs to first of all get rid of a handful of problematic bishops in Chile, Barros included, and then rid himself of the “toxic” churchmen who repeatedly discredit, demean and defame victims for the sake of protecting the church.years it has emerged as an activator of the PLC signalling pathway and hence, PKC activation ([Figure 2](#cancers-07-00836-f002){ref-type="fig"}) \[[@B94-cancers-07-00836]\].

Protein Kinase C appears to be a key intermediate in integrin mediated signalling and while much of the research on integrins and PKCs has focused on the regulation of integrin activity by PKCs, recent studies also highlight that integrins play a central role in mediating activation of PKCs \[[@B95-cancers-07-00836],[@B96-cancers-07-00836]\]. Extracellular matrix proteins cluster and activate integrins which in turn induce the PLC signalling cascade and the activation of PKCs, in a process termed outside-in signalling ([Figure 2](#cancers-07-00836-f002){ref-type="fig"}). This activation of PKCs results in a mobilization of calcium levels within the cell and consequently further activation of integrins, a phenomenon referred to as inside-out signalling \[[@B95-cancers-07-00836],[@B97-cancers-07-00836],[@B98-cancers-07-00836],[@B99-cancers-07-00836]\]. Consequently, PKC activation has a


lab surprisingly demonstrated the majority of mutations found in PKCs resulted in a loss of function and none were activating \[[@B160-cancers-07-00836]\]. Further to this, meta-analysis on patients with non-small cell lung cancer in controlled trials of PKC inhibitors, combined with chemotherapy in comparison with chemotherapy alone, revealed that PKC inhibitors significantly decreased response rates and disease control rates \[[@B161-cancers-07-00836]\].

The ideas presented in this review highlight the challenges in targeting PKCs; clearly defining which PKC isozyme is displaying a tumour suppressor and/or tumour promotor roles and in which tissues proves to be a difficult task. Protein Kinase Cs are key intracellular targets for growth factor and adhesion signaling pathways so perhaps a refocus and revisit of the pathways upstream of PKCs presents a more favourable approach to targeting thisis still pretty funny. The memes were pinging around the internet within miliseconds of the draw being made - almost as if they had been prepared in advance. “Hello again!” tweeted the official Bayern account at the official Arsenal account, accompanied by a meme from Groundhog Day. Truly, we are living in a post-banter world.


Instructs the ARM processor to move the radio state to the off state
 *
 * When the ARM moves from the Radio On state to Radio Off (Idle) the ARM tracking calibrations
 * are stopped and the TxEnable/RxEnable, etc GPIO control pins will be ignored.  This will also
 * keep the receive and transmit chains powered down until the TALISE_radioOn() function
 * is called again.
 *
 * \pre This function may be called any time TALISE_radioOn had been called previously
 *
 * \dep_begin
 * \dep{device->devHalInfo}
 * \dep_end

 * \param device Pointer to the device settings structure
 *
 * \retval TALACT_WARN_RESET_LOG Recovery action for log reset
 * \retval TALACT_ERR_CHECK_PARAM Recovery action for bad parameter check
 * \retval TALACT_ERR_CHECK_TIMER Recovery action for timer time-out check required
 * \retval TALACT_ERR_RESET_SPIfully initialized
 *      and the init cals have already run. This can be called in the
 *      radio On or Off state.
 *
 * \note In radio Off, this function will read back RF PLL
 *
 * \dep_begin
 * \dep{device->devHalInfo}
 * \dep_end
 *
 * \param device Pointer to the Talise device data structure containing settings
 * \param orx1LoSource Returns ORx1 LO source (RFLO or AuxLO)
 * \param orx2LoSource Returns ORx2 LO source (RFLO or AuxLO)
 *
 * \retval TALACT_WARN_RESET_LOG Recovery action for log reset
 * \retval TALACT_ERR_CHECK_PARAM Recovery action for bad parameter check
 * \retval TALACT_ERR_RESET_SPI Recovery action for SPI reset required
 * \retval TALACT_ERR_CHECK_TIMER Recovery action to debug why HAL layer timer returned an error
 * \retval


Altered levels of circulating GABAergic 5α/β-reduced pregnane and androstane steroids in schizophrenic men.
The role of GABAergic pathways in the pathophysiology of schizophrenia is generally accepted. Therefore, the information concerning alterations of the steroid metabolome associated with the disease and/or its treatment is of interest with regard to the pathophysiology of the disease. Hence, we assessed 18 serum steroids and steroid polar conjugates in a group of drug-naive patients (13 adult men) and after 6-months therapy by atypical antipsychotics and age-matched controls (19 men) using gas chromatography-mass spectrometry analysis. This study, for the first time, demonstrates the altered circulating GABAergic steroids in schizophrenic men as well as the effect of the therapy with two types of atypical antipsychotics. The GABAergic androsterone (3α5α) and etiocholanolone (3α5β) are reduced in schizophrenicif commenced at different times"; and Code § 28-105 reads: "The creditor may not pursue the person and property of the debtor at the same time, except in cases specially provided for; but the process last sued out shall be void."
There are other Code sections stating in different applications the general rule that there can be but one suit and one recovery on the same cause of action. Code §§ 3-607, 110-501. If the provisions of Code § 8-104, as contended by the plaintiff in error, extend only to attachments issued under Code § 8-101 and not to fraudulent-debtor attachments issued under Code § 8-401, the plaintiff in error's position is correct, and the attachment proceedings in which the judgment excepted to was obtained was void, and the


where the plaintiff has commenced suit for the recovery of his debt, and the defendant, during the pendency of such suit, shall become subject to attachment, agreeable to the first section of this act, the *383 plaintiff upon complying with the provisions of this act, in relation to the issuing of attachments, may have an attachment against the defendant and all the proceedings in relation to the same shall be, as hereinbefore prescribed, in relation to attachments, where no suit is pending. And a satisfaction of the judgment in the common-law action shall satisfy the judgment in attachment, and a satisfaction of the judgment in attachment shall satisfy the judgment in the common-law action." It clearly appears that Section 28 of the act of 1856 referred exclusively toby the omission of the clause was to make available the remedies of purchase-money and fraudulent-debtor attachments in common-law actions under the provisions of the Code of 1895, such remedies obviously not existing when the Code of 1882 (revised) was the statute law of the State.
But if the intention of the legislature was then in doubt, when, after the lapse of more than fourteen years, Code § 5071 (1910) was adopted, identical with Code § 4526 (1895), the doubt would be diminished if not dissipated altogether. It would seem improbable that two codifying legislatures would by inadvertence overlook a matter so important and so apparent.
This view is fortified by the fact that, during the interim between the adoption of the Codes of 1895 and 1910, the trial courts


the attachment proceeding has been conclusively adjudicated by the judgment previously rendered in the common-law action for the money of the debt evidenced by the note.
Judgment affirmed. Gardner, P. J., Carlisle and Nichols, JJ., concur. Felton, C. J., and Townsend, J., dissent.

ON REHEARING.
The plaintiff's proof showed: that the defendant owed him a debt which had been reduced to judgment before the trial of the instant case in the trial court; that, pending the suit that resulted in the judgment, the defendant had actually sold farm equipment owned by him to one who was not a creditor. This created a presumption that the allegation of the petition that the defendant was selling his property to hinder, delay and fraudulently defeat the plaintiff in the collection of the debt suedin MK7 must be rather big.That said, It could absolutely happen. Me being skeptical is just indicative of the fact that lots of Switch news right now is still unreliable and that new hurdles have arisen with this generation that make it not a "duh" feature.


counsel entered in the District Court an application for leave to file a second motion (or amended motion) based on the voluntariness of petitioner's plea of guilty to vacate sentence under 28 U.S.C. 2255.  The district court denied this application on March 14, 1969.  Thereafter, this Court granted appellant's motion to supplement the record in the appeal of the petitioner's first motion.  This was done and the Court now has before it the first 2255 motion filed by the petitioner, as well as the second one.

2
Petitioner's first 2255 motion was based on the alleged unconstitutionality of 18 U.S.C. 1111.  Subsection (a) of that statute defines first and second degree murder.  Subsection (b), at issue here, provides:

3
Whoever is guilty of murder in the firstfirst be required to hold that there is a constitutional right to waiver of a jury trial.  The Supreme Court, however, has stated that there is no constitutional right to waiver.  United States v. Jackson, supra; Singer v. United States, 1965, 380 U.S. 24, 85 S.Ct. 783, 13 L.Ed.2d 630.  Since section 1111 does not interfere with any constitutional right, we affirm the district court's denial of petitioner's first 2255 motion.

5
Petitioner's 'Application for Leave to File a Second Motion (or amended motion) to Vacate Sentence under 28 U.S.C. 2255' was properly denied by the district court.  In Womack v. United States, 1968, 129 U.S.App.D.C. 407, 395 F.2d 630, the court stated:

6
We are of the view that there is no jurisdictional bar to the District


Coordinates

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Mairie annexe,20144 Sainte Lucie de Porto Vecchio,Corse-du-Sud

Phone : 0033 (0)4 95 71 48 99

Opening hours:
- From October till May: from Monday to Friday from 8:30 am till 12:00 am and from 2:00 pm till 5:30 pm.
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We use cookies to ensure that we giveVehicles with heat engines are nowadays equipped with exhaust lines that include pollution control members such as catalytic purification members and/or particle filters. In order to permit satisfactory operation of such pollution control members it is necessary for the exhaust gases to reach them at a high temperature. It is therefore expedient to avoid too great a loss of heat in the exhaust line and especially in the manifold separating the outlet of the heat engine from the first pollution control member.
Various solutions have been envisaged to that end. In particular, manifolds comprising internal ducts maintained in an outer shell separated from the internal ducts by an air space or an insulating material are found to be effective in avoiding too great a loss of heat.
Such manifolds comprise


Russians were transferred to Estonia and given jobs in new industries and other privileges.

Estonia became independent again in 1991, after the collapse of the Soviet Union.

Since then, the shoe has been on the other foot to some extent.

No one gets citizenship automatically unless their family was resident prior to the Soviet occupation (and that does include quite a few ethnic Russians).

You can qualify for citizenship if you achieve a level of proficiency with the Estonian language, but many Russian speakers have found that hard. As of 2012, about 7 percent of Estonia’s residents are still denied citizenship.

In addition, the use of the Estonian language is mandatory in certain work environments, such as among all public-sector employees and medical professionals. So Russian-speakers are denied access to a lot ofthe bark is damaged.
U.S. Pat. No. 4,150,526 attempts to address the problem of waste by providing a collector leaf construction that includes a primary and a secondary leaf portion and claims that the separate movement of each portion covers more of the space under a blueberry bush thus reducing the waste from 35-50 percent to 15 percent (column 4, lines 53-59). U.S. Pat. No. 4,464,888 also addresses the problem of waste by employing a collector leaf having a particular shape, primarily a concave leading edge and a convex trailing edge. FIGS. 4 and 5 of that patent illustrate how that shape covers more of the space around a plant trunk or trellis post such as support grape bushes thereby producing a saving of 12 to 15 percent (column


1. Field of the Invention
The present invention relates to card connectors. Particularly, the present invention relates to manufacturing card connectors that electrically connect to a miniature memory card such as a micro SD (Secure Digital) card being inserted into the connector.
2. Related Art
A memory card, which is a card-shaped memory device, employs flash memory as a memory medium. The memory card is extremely compact and consumes very little electrical power in reading and writing data. For these reasons, memory cards have become popular as a memory medium for hand-held information devices, as represented, for example, by camera-cellphones and PDAs (Personal Digital Assistant).
In the past, memory cards had the image of having low memory capacity, yet higher costs, compared to other disk-shaped memory devices such as flexible disks (FD)Tyrannosaur Canyon

Tyrannosaur Canyon is a novel by Douglas Preston published on August 11, 2005 by Forge Books. It is the first book in the Wyman Ford series. The story revolves around the search for a mysterious item buried in the New Mexico desert.

Plot summary
The novel opens with a lunar find by the Apollo 17 astronauts, which is suppressed.

Tom Broadbent (who first appeared in Preston's novel The Codex) is riding in the New Mexico desert when he hears gunshots coming from Tyrannosaur Canyon (a fictional canyon east of the Rio Chama Gorge, on Mesa Viejo, and north of the Monastery of Christ in the Desert). Following the sound, he comes upon an old prospector who has been shot by a sniper. He gives Tom a notebook just before he


to the parties’ expectations.”

So, if a seller uses this clause but discovers before closing that the house was a grow-op, or contains Kitec plumbing, do they have to disclose the discovery? Even if there is no right to terminate the contract?I don’t abuse it.

The pursuit, even of the best things, ought to be calm and tranquil – Marcus Tullius Cicero

“OMG, what is that noise? A leaf? Is it going to kill us? No?

Should I run away? No?

What the heck was that!? A Car? Will that kill me? No?

WHAT ABOUT WHEN IT DRIVES OVER THE MANHOLE COVER?!?!? Let’s run!! No?

Okay, but those people talking 30 feet away from us are a threat right? No?

What about those dogs?? All a no?

Hey, have you checked behind us 20 times in the last 30 seconds? No? Well, I have. Nothing back there.

What’s that smell on the sidewalk? I’m going to keep my nose glued to it, okay? No? I should pay attention to the walk? Okay.

I’ll sit, but I need to face


her dog the activity she needs no matter what. Maybe the day they go for a shorter walk they play Frisbee for a little longer. But, she doesn’t let her dog’s fearfulness get in the way of what her dog needs.

3. She doesn’t baby her. There’s no coddling. No cooing. Nothing is scary so she doesn’t act like it is. Moving on.

4. She answers every question. Hands down. She just keeps answering. It can be exhausting, but she does it. This is what her dog needs, so she will provide it.

5. She focuses on the victories, even the small ones. If she’s able to walk her dog past a car without having to answer a question, then she’s happy. If she’s able to not have a scared pupthreat?Yes.Should I make it go away?Yes.

And that right there is dog reactivity in a nutshell. If I don’t answer her questions, she has to come up with her own answers which are always the wrong answer. So I Pilot her. When she’s asking an important question (“Is it a threat?”) and trying to cipher it out for herself, her body language changes. Her ears go stiff. Her forehead wrinkles between her ears. Tail goes straight up. She’s about to answer a question for herself, and that’s bad.

Total protonic reversal. Or in layman’s terms, she flips her lid.

So I Pilot her by answering her questions (learn how here), and we have a nice walk. I don’t always know what question she’s asking in specific, but that doesn’t preclude me


friends use retractable leashes, by the way), so I asked Karis if she was comfortable walking Porter by the other dog or not.

She was honest and said that she wasn’t comfortable with that yet, so we switched dogs back. No big deal. You can switch dogs as much and as many times as you want and whenever you want. Keep it interesting, but also keep it within your comfort zone.

5. You’ll want to go again

- Going on a walk with someone else is fun! You can catch up on each other’s lives. You can complain about your dogs. You can talk about the latest episodes or bounce new ideas off of each other.

What all that talking does is, makes you forget about your dog. Your instincts will kickneck. She’s completely removed from the amount of damage she’s inflicting upon him, sort of like the President pushing the “nuke button”. It’s just the simple pressing of a button to him, but the effects are far beyond that little bit of effort. The input isn’t the same as the output. I do not feel that a human should ever be so far removed from what they are doing to their dog. I know exactly howmuch force I’m putting into the slip lead because I can feel it on my end. It’s equal from me to him. There’s no barbs on the end of it. I’m not keeping it engaged and tight. More importantly, I’m answering my dog’s questions with body language rather than causing them pain for


working on these skills for so long. It’s muscle memory now, so let your muscles take over.

– Brittany Graham Photography

The other day, while on a hike with Porter, we were starting to go up a set of stairs. Porter is not very good at stairs. First of all, he’s just absolutely uncoordinated when it comes to them because he never has to do them on a daily basis. Second of all, it takes a lot of Piloting to make sure he goes up the stairs at a pace that’s safe for me. So, as we’re walking up the stairs, I notice another dog on the landing. All of a sudden my brain started going into overdrive.

Should I move Porter to the other side of me?

What happens if this $routes =   C('URL_ROUTE_RULES');
        if(!empty($routes)) {
            foreach ($routes as $rule=>$route){
                if(is_numeric($rule)){
                    // 支持 array('rule','adddress',...) 定义路由
                    $rule   =   array_shift($route);
                }
                if(is_array($route) &&


the trade deadline, he essentially swapped Andrei Loktionov for Tuomo Ruutu. Ruutu may turn out to be good but he is not likely the scorer they needed - and the team remained to have load of defensemen. If you feel the problem with this season's team is a lack of talent and not addressing needs mid-season, then a finger has to be pointed at the man at the top.

Why It May Not Be the Biggest Problem: Other than the site being named after him? OK, he's just the overseer. He really comes into play with respect to larger personnel decisions like acquiring players, trades, and so forth. Probably calling up and demoting players as well. As involved as a GM gets, he tries to get the talent that'savailable. He's not a mindreader. He couldn't have predicted Ryane Clowe getting a significant injury and then going cold after an initial warm-up period. Nor Michael Ryder not scoring in over two months now. Or Brunner not working out well. Or Olsez not working out at all. Or a 42-year old Jagr leading the team in scoring. At the trade deadline, the Ruutu deal may have been the one to make without it being costly, though I would've preferred taking a shot at Ales Hemsky at this point. Lou doesn't let on what goes behind the scenes so it's difficult to fully criticize what was and was not done. Like with DeBoer, the players have to play. Unlike DeBoer, the coaches have to coach up the players. As


and divisions among the former nationalist movements. The Angolan government enjoyed significant military assistance from the Soviet Union and Cuba and conducted a semi-conventional war against UNITA, which in turn was supported by its apartheid South Africa backers and encouraged by the West. However, this conflict had been transformed into a low intensity conflict by the end of 1998, and the government of Angola increasingly took on the attributes of a predatory state. During the last years of the war, huge sums of money simply unaccountably disappeared from government coffers, and the population grew ever more impoverished.

Second, unaccountable governments with large revenue streams at their disposal have multiple opportunities to divert funds for illegal purposes. When such a government is involved in armed conflict, the resulting rights abuseswithin Liberia. Meanwhile, Liberia remained one of the poorest countries in the world.

Despite international arms embargoes, the Taylor government spent millions for his own wars and to supply the RUF, using revenue from government-controlled diamond and timber sales, and from monies diverted from Liberia’s lucrative maritime registry. An arms embargo was placed on all parties to the civil war in Liberia in 1992 after the Economic Community of West African States intervened militarily in large part to prevent Taylor, at the time leader of rebel forces known as the National Patriotic Front for Liberia, from taking power. The sanctions remained in effect when Taylor subsequently was elected president of Liberia in 1997 but were largely ineffective because they were poorly enforced. It was only after the U.N. Security


from September 1999 to July 2002, admitted, “revenue was largely diverted,” for the “war effort. But there was no kind of accountability.” At least U.S.$1.6 million of maritime revenue was used for sanctions-busting from 2000 through 2001.

Timber revenue was also problematic. The U.N. Liberia panel of experts was able to document how Taylor used these resources to violate sanctions. In one case, the panel documented nine payment instructions for a total of U.S.$7.5 million from 1999 to 2001 to nine different bank accounts. These were all off-budget expenditures from the timber industry. Two of these were used as payments for defense-related expenditure.

On May 6, 2002, prior to the introduction of timber sanctions in July 2003, the U.N. Security Council passed Resolution 1408 (2002). That resolution included a requirementto audit revenues derived from the shipping registry and the Liberian timber industry in order to ensure that the revenue is used for “legitimate social, humanitarian and development purposes.” It represents the first time that the Security Council has insisted upon an audit. The Security Council formally linked misuse of government revenues and sanctions busting to reducing human rights abuses and spending more resources on social programs by calling for an audit.

The Liberian government did very little in response to the resolution. It commissioned a systems and management audit, one that avoided any financial analysis. There remains an important opportunity to ensure that the timber revenues are appropriately audited and managed. The international community should encourage and provide technical assistance for a full audit and the creation of


fully effective in promoting greater transparency and accountability.

To its credit, the IMF has been a forceful proponent of such measures in Angola and Liberia. Human Rights Watch does not take a position on the work of the international financial institutions per se but can and does examine the positive or negative impact their activities can have on human rights. Whatever one thinks of the IMF’s economic prescriptions, its efforts to promote transparency in Angola and Liberia have been an important source of leverage for those interested in human rights improvements in the country. It has so far refused to enter into a program with the Angolan government until more transparency is evidenced. In Liberia, which has had its IMF voting rights and related privileges suspended, the fund hasThe jet temperature decreases in the direction of the outlet opening as a result of heat losses via the side walls and the bath level surface, with the temperature loss between the feed location and outlet location being dependent on the throughput.
The foreign substances in the metal melt, which are to be separated out as efficiently as possible, originate firstly from the steelmaking process, and are flushed out of the casting ladle into the tundish when the metal melt is transferred. Secondly, foreign substances are also introduced into the metal melt in the tundish itself. These foreign substances originate from the refractory lining material of the tundish and/or from the liquid steel covering slag which is generally used, and are abraded and suspended firstly through mechanical erosion as


String): Unit def consumeFirstMessageFrom(topic: String): String

It also provides many more methods which can be used according to need.

For complete example click here.

Good things is that we can also test our kafka stream in similar way. For that, we have to add following dependency in build.sbt. And extend your spec with EmbeddedKafkaStreamsAllInOn.

“net.manub” %% “scalatest-embedded-kafka-streams” % “0.14.0” % “test”

For more information on testing of kafka stream, you can use links in references.

So, Embedded Kafka has made easier the unit testing of kafka. Besides that, embedded kafka is also very easy to use.

Hope, this blog will help you 🙂

References:In the slipping replacement method, a user data area with the defect is slipped and the next user data area having no defects is used.
Both linear replacement and slipping replacement methods are, however, applicable only to discs such as a DVD-RAM/RW, on which data can be repeatedly recorded and recording can be performed using a random access method. In other words, the conventional linear and slipping replacement methods cannot be applied to write once discs on which recording is allowed only once. Specifically, the presence of defects in a disc is generally detected by recording data on the disc and confirming whether the data has been recorded correctly on the disc. However, once the data is recorded on a write once disc, it is impossible to overwrite new


Physicists from across the U.S. and from around the world conduct research at Jefferson Lab, seeking to expand our knowledge of the visible universe. Currently, more than 1,300 users (visiting scientists and students) conduct research at the lab.

CAREERS AT JEFFERSON LAB

Welcome to Jefferson Lab, a world-leading nuclear physics research facility, where great ideas and great people can thrive.

At Jefferson Lab, you can work with exceptional people, grow your skills and advance your career. Our team includes more than 800 people, including physicists, engineers, computer technicians and more.

Together, you and Jefferson Lab can build a career that's uniquely yours.

The Human Resources group is fully integrated with Jefferson Lab's mission and is committed to providing quality customer service based on expertise, innovation and integrity.In the final analysis there is no solution to man’s progress but the day’s honest work, the day’s honest decisions, the day’s generous utterances and the day’s good deed.

— Clare Booth Luce

Register for a School

Click here for more information on the Livestock Marketing school coming up in Helena, MT on June 30-July 1, 2020.
Click here for more information on the Marketing and Stockmanship school coming up near Middlebury, VT on August 20-22, 2020.


$\%$ of $\kappa$ at 0.1 K via the phonon specific heat [@hartmann2] with an assumption of boundary scattering limited conduction. Under zero field, we find a remarkable upturn in $\kappa(T)/T$ below the N$\acute{\rm e}$el ordering temperature $T_{\rm N}\approx$ 0.07 K. At 0.5 T, $T_{\rm N}$ is reduced to $\sim$ 0.05 K, and it entirely disappears at the critical field $B_{\rm c}$ = 0.66 T (the upper inset of Fig. \[fig.1\]). Even above $B_{\rm c}$, $\kappa(T)/T$ shows a steep increase down to the lowest temperature, but it is less sensitive to the fields up to 3 T. A FL-like saturation behavior is eventually observed below about 0.06 K at 5 T. The lower inset shows the field dependence of $\kappa(B)/T$ measured at 0.051 K. We find a rapid decrease of $\kappa(B)/T$the electric charge transferring material. In Japanese Laid-Open Patent Publication No. 1-206349, there is suggested that a compound having a diphenoquinone structure is used as the electron transferring material for electrophotosensitive material.
However, it is difficult for electron transferring materials such as diphenoquinones to match with the electric charge generating material, which results in insufficient injection of electrons from the electric charge generating material into electron transferring material. Therefore, sufficient photosensitivity could not be obtained. Further, the single-layer type organic photosensitive layer had a problem that an interaction between diphenoquinone and a hole transferring material inhibits electrons from transferring.
Further, regarding the polarity of the photosensitive material to be charged, the scope of application of the photosensitive material can be widen if one photosensitive material can be used for both


searches have not yet revealed any presence of new physics, rare processes in the quark sector remain a good territory to search for new sources of CP violation. This is especially the case for the kaon physics observables $\varepsilon$ and $\varepsilon^\prime$, which measure indirect and direct CP violation in $K^0$-$\bar K^0$ mixing and $K^0$ decay into $\pi\pi$, respectively.

Recently, there has been a renewed interest in the ratio $\epe$ [@Buras:2014sba; @Buras:2015yca; @Blanke:2015wba; @Buras:2015kwd; @Buras:2016dxz; @Buras:2015jaq; @Kitahara:2016otd; @Endo:2016aws; @Endo:2016tnu; @Cirigliano:2016yhc; @Alioli:2017ces; @Bobeth:2016llm; @Bobeth:2017xry; @Crivellin:2017gks; @Bobeth:2017ecx; @Endo:2017ums; @Haba:2018byj; @Chen:2018ytc; @Chen:2018vog; @Matsuzaki:2018jui; @Haba:2018rzf], due to hints for a significant tension between measurements and the SM prediction from the RBC-UKQCD lattice collaboration [@Bai:2015nea; @Blum:2015ywa] and the Dual QCD approach (DQCD) [@Buras:2015xba; @Buras:2016fys]. While on the experimental side the world average from the NA48mass thresholds [@Buchalla:1995vs].

Assuming that no particles beyond the SM ones with mass below the electroweak scale exist, any BSM effect is encoded in the Wilson coefficients of the most general $\Delta S = 1$ dimension-six effective Hamiltonian. The values of the Wilson coefficients $C_i({{\mu_\mathrm{ew}}})$ in this effective Hamiltonian at the electroweak scale with $N_f = 5$ active quark flavours, $$\begin{aligned}
  \label{eq:DS1-Hamiltonian}
  \mathcal{H}_{\Delta S = 1}^{(5)} &
  = - \mathcal{N}_{\Delta S = 1} \sum_i C_i \, O_i \,,\end{aligned}$$ are connected to those of $\mathcal{H}_{\Delta S = 1}^{(3)}$, entering $\epe$, by the usual QCD and QED renormalization group (RG) evolution. In full generality, three classes of operators can contribute, directly or via RG mixing, to $K\to\pi\pi$ decays:

#### four-quark operators:

$$\begin{aligned}
  \label{eq:DS1-psi4-col1}
  O_{XAB}^q &
  = (\bar


technical intricacies of these analyses.

Writing $$\begin{aligned}
  \label{eq:mastertotal}
  \left(\frac{\varepsilon'}{\varepsilon}\right) &
  = \left(\frac{\varepsilon'}{\varepsilon}\right)_\text{SM}
  + \left(\frac{\varepsilon'}{\varepsilon}\right)_\text{BSM},\end{aligned}$$ our formula allows to calculate automatically $(\epe)_\text{BSM}$ once the Wilson coefficients of all contributing operators are known at the electroweak scale ${{\mu_\mathrm{ew}}}$. It reads as follows: $$\begin{aligned}
  \label{eq:master}
  \left(\frac{\varepsilon'}{\varepsilon}\right)_\text{BSM} &
  = \sum_i  P_i({{\mu_\mathrm{ew}}}) ~\text{Im}\left[ C_i({{\mu_\mathrm{ew}}})-C^\prime_i({{\mu_\mathrm{ew}}})\right],\end{aligned}$$ where $$\label{eq:master2}
  P_i({{\mu_\mathrm{ew}}})  = \sum_{j} \sum_{I=0,2} p_{ij}^{(I)}({{\mu_\mathrm{ew}}}, {{\mu}})
  \,\left[\frac{\langle Q_j ({{\mu}})\rangle_I}{\text{GeV}^3}\right]\,.$$

     class    $O_i$                                                      659
   \[0.1cm\]  $O_{VLL}^d = (\bar s^i \gamma_\mu P_L d^i)(\bar d^j \gamma^\mu P_L d^j)$                                $2.3 \pm 0.5$                             48
              $O_{VLR}^d = (\bar s^i \gamma_\mu P_L d^i)(\bar d^j \gamma^\mu P_R d^j)$


of the former approach compared to the sophisticated and computationally demanding numerical lattice QCD one. The most recent example of this agreement was an explanation by DQCD of the pattern of values of $B_6^{(1/2)}$ and $B_8^{(3/2)}$ entering $\epe$ obtained by lattice QCD [@Buras:2015xba; @Buras:2016fys] and of the pattern of lattice values for BSM parameters $B_i$ in $K^0$-$\bar K^0$ mixing [@Buras:2018lgu]. This should be sufficient for the exploration of new phenomena responsible for the hinted $\epe$ anomaly. Similar comments apply to the hadronic matrix element of the chromo-magnetic dipole operator, entering mainly the $P_i$ in Class B, that was recently calculated in DQCD in [@Buras:2018evv] and found to be in agreement with the lattice QCD result from [@Constantinou:2017sgv]. Since the $P_i$ in Class B only receive a single contribution, their relative<?php

namespace craft\migrations;

use Craft;
use craft\db\Migration;
use craft\db\Query;
use craft\db\Table;
use craft\elements\User;
use craft\helpers\ArrayHelper;
use craft\helpers\DateTimeHelper;
use craft\helpers\Json;
use craft\services\ProjectConfig;

/**
 * m180521_173000_initial_yml_and_snapshot migration.
 */
class m180521_173000_initial_yml_and_snapshot extends Migration
{
    /**
     * @inheritdoc
     */
    public function safeUp()
    {
        $this->addColumn(Table::INFO, 'configMap', $this->mediumText()->null()->after('maintenance'));

        $projectConfig = Craft::$app->getProjectConfig();

        $configFile = Craft::$app->getPath()->getProjectConfigFilePath();

        if (file_exists($configFile)) {
            // Make a backup of the old config
            $backupFile = pathinfo(ProjectConfig::CONFIG_FILENAME, PATHINFO_FILENAME) . date('-Ymh-His') . '.yaml';


   $this->dropTableIfExists('{{%systemsettings}}');

        $this->dropColumn(Table::PLUGINS, 'settings');
        $this->dropColumn(Table::PLUGINS, 'licenseKey');
        $this->dropColumn(Table::PLUGINS, 'enabled');
    }

    /**
     * @inheritdoc
     */
    public function safeDown()
    {
        echo "m180521_173000_initial_yml_and_snapshot cannot be reverted.\n";

        return false;
    }

    /**
     * Return project config array.
     *
     * @return array
     */
    private function _getProjectConfigData(): array
    {
  Treatment of nonunions of long bone fractures with shock waves.
A prospective clinical study investigated the effectiveness of shock waves in the treatment of 72 patients with 72 nonunions of long bone fractures (41 femurs, 19 tibias, seven humeri, one radius, three ulnas and one metatarsal). The doses of shock waves were 6,000 impulses at 28 kV for the femur and tibia, 3,000 impulses at 28 kV for the humerus, 2,000 impulses at 24 kV for the radius and ulna, and 1,000 impulses at 20 kV for the metatarsal. The results of treatment were assessed clinically, and fracture healing was assessed with plain radiographs and tomography. The rate of bony union was 40% at 3 months, 60.9% at 6 months, and 80% at 12 months followup. Shock wave treatment


around."

Mr Dutton's comments followed the release of a letter organised by the Australian Marriage Equality organisation — and signed by 20 chief executives, including Mr Joyce — which called on the Prime Minister to legislate same-sex marriage.

Qantas defended its decision in a public statement and vowed to continue supporting same-sex marriage.

Writing on the Qantas website on Tuesday, Mr Joyce said companies did have a role in the community "beyond selling it things".

"In the past few years alone, Qantas has given its support widely. Charity flights for drought relief. Awareness raising for homelessness. Transporting volunteer firefighters around the country," he said.

He listed Qantas's support for same-sex marriage alongside its recognition for Indigenous people and campaigns for gender equality.

Mr Joyce also wrote that it was an economic issue, saying, "morewebsite has a section with some beautiful maps selected every month.

A:

OpenStreetMap (http://openstreetmap.org)
MapBox (http://mapbox.com/) - for creating custom maps in the cloud using OpenStreetMap and other data sources

For historic maps:

Perry-Castañeda Library Map Collection at University of Texas (http://www.lib.utexas.edu/maps/)
Library of Congress map collection (http://lcweb2.loc.gov/ammem/gmdhtml/gmdhome.html)

A:

Some more:

http://somethingaboutmaps.wordpress.com/
http://www.cartogrammar.com/portfolio.html
http://timwallace.wordpress.com/page/2/
http://indiemaps.com/portfolio/


Q:

Changing Number type to Text type when import csv by vba

I got an import csv code below
Private Sub Workbook_Open()
 Dim xFileName As Variant
    Dim Rg As Range
    Dim xAddress As String
    xFileName = Application.GetOpenFilename("CSV File (*.csv), *.csv", , , , False)
    If xFileName = False Then Exit Sub
    On Error Resume Next
    xAddress = Range("A1").Address
    With ActiveSheet.QueryTables.Add("TEXT;" & xFileName, Range(xAddress))
        .FieldNames = True
        .RowNumbers = False
        .FillAdjacentFormulas = False
        .PreserveFormatting = True
      140/90 mmHg were 136/90 mmHg. There were 43% classified as hypertensive due to either ABPM 24-h more than 130/80 mmHg (17%) or taking antihypertensive therapy (25%). Ambulatory SBP/DBP were higher in men (24-h + 6.4/4.9 mmHg, P < 0.001) compared with women. There was only 3% with white-coat but 21% with masked hypertension indicating 24% misdiagnosis. Based on ABPM, 9% were treated and still hypertensive, which was three times more common in men (14%) than women (4%). Thus 36% had not reached target. There were no differences between urban and rural participants. Based on ABPM, nearly half the participants were hypertensive while only a quarter were taking antihypertensive therapy. The findings highlight the importance of out-of-office BP assessments and the considerable gaps in effectively diagnosing and treating hypertension.


9, 0 = k*a + 4*s for a.
-5
Suppose -7*v = -3*v - 16. Suppose 4*w + 5*b - 36 = 0, 2*w = -v*b - b + 28. Suppose -w*r + 9*r = 30. Solve 0 = 4*f + 5*c - r - 21, -3*c + 24 = 5*f for f.
3
Let k(s) = 5*s + 18. Let g(o) = 11*o + 36. Let x(f) = -6*g(f) + 13*k(f). Let a be x(14). Solve 7*p = 2*b + 4*p - 13, -a*b + 4*p + 24 = 0 for b.
5
Let u(t) = -t**2 - 21*t - 15. Let j be u(-20). Solve w = j*w - 5*c, -3*c = 0 for w.
0
Suppose -9*z + 38 + 16 = 0. Suppose -3*j + z = 6. Solve -18 = -2*qd - 6*d + 10 = 0. Let m be (d/(-4))/((-2)/(-4)). Let q be m - (4 + -2)/(-2). Solve 5*g + 5*h + 1 - 11 = q, -g = -5*h - 14 for g.
4
Let w = 661 + -661. Solve -4 = -4*v - 3*t - w, -4*t = -v + 20 for v.
4
Let m = 1 - -2. Let q(h) = h**2 - 3*h + 2. Let z be q(2). Suppose z*b - 9 = -3*b. Solve 3*t + 9 = -s, s + b = 2*s - m*t for s.
-3
Suppose -2*n - 17 = 15. Let s = 11 + n. Let t(q) = -3*q - 12. Let g be t(s). Solve g*v - 5*d - 7 = 0, 0*v + d = v


771 So.2d 175 (2000)
Steve BLACKBURN, et al.
v.
NATIONAL UNION FIRE INSURANCE CO. OF PITTSBURGH.
Steve and Wendi Royer
v.
Scafco, Ltd., et al.
Nos. 99-1872, 99-1873.
Court of Appeal of Louisiana, Third Circuit.
August 23, 2000.
Writ Granted November 27, 2000.
Writs Denied November 27, 2000.
*177 David O. Walker, Neblett, Beard & Arsenault, Alexandria, Louisiana, Counsel for Plaintiffs/Appellees.
Michael J. McNulty, III, Plauche, Smith, & Nieset, Lake Charles, Louisiana, Counsel for Defendant/Appellee, State Farm Mutual Automobile Ins. Company.
Thomas E. Balhoff, Judith R. Atkinson, Roedel, Parsons, Koch, Frost, Balhoff & McCollister, Baton Rouge, Louisiana, Counsel for Defendant/Appellant National Union Fire Insurance Company of Pittsburgh, Pennsylvania.
Court composed of Judge OSWALD A. DECUIR, Judge MICHAEL G. SULLIVAN, Judge GLENN B. GREMILLION.
GREMILLION, Judge.
This appeal arises out of a rear-end collision involving a truck leased by Scafco Limited and insured by National Unionwhile an employee was acting outside the course and scope of his employment or without the permission of his employer. Endorsement MCS-90 limited provisions found elsewhere in the policy for certain types of motor carriers, making the insurer liable for up to $1,000,000 in damages as a result of an accident.
National Union filed a motion for summary judgment asserting that under Endorsement # 005, the limits of liability coverage for Rials' accident were limited to $10,000 per person or $20,000 per accident. The Blackburns, the Royers, Rials, and State Farm opposed National Union's motion and filed a cross-motion contending that the National Union policy limits for the accident were $1,000,000 regardless of whether Rials was operating the vehicle outside of the course and scope of his employment.
Scafco and


with Sections 29 and 30 of the Motor Carrier Act of 1980 and the rules and regulations of the Federal Highway Administration (FHWA) and the Interstate Commerce Commission (ICC).
[T]he insurer (the company) agrees to pay, within the limits of liability described herein, any final judgment recovered against the insured for public liability resulting from negligence in the operation, maintenance or use of motor vehicles subject to the financial responsibility requirements of Sections 29 and 30 *181 of the Motor Carrier Act of 1980 regardless of whether or not each motor vehicle is specifically described in the policy and whether or not such negligence occurs on any route or in any territory authorized to be served by the insured or elsewhere. Such insurance as is afforded, for public liabilitystrengths included patterns such as being a knowledgeable and strategic teacher, creating a positive learning environment, demonstrating professionalism, displaying scholarly traits, and being supportive. Weaknesses included patterns such as poor delivery of content, acting disorganized, being inaccessible, displaying weak teaching skills, being dishonorable, being unprofessional, and displaying negative traits. Implications for continuous quality improvement in teaching/learning processes are presented.


further away from
any such solution than we were just six or eight years ago, when George
W. Bush and some of his more enlightened Republican allies tried to
think seriously about the question but were shot down by conservatives
in their own party. The advent of Barack Obama has meant that alarming
numbers among us cling not just to God and guns (as Obama once
infelicitously put it) but to the conviction that the president must be a
foreigner or a Marxist or a Muslim or even the Antichrist, and not
merely cool, cerebral, and—oh, yes—black. A recent poll by the Pew
Research Center’s Forum on Religion & Public Life found that the
percentage of conservative Republicans who think Obama is a Muslim has
more than doubled over the past four years, from 16 percent in 2008 to
34and leaving us with only automatons and demented narcissists willing to climb the mountain:
READ MORE

In the United States, the Supreme Court has final say over whether
any law is constitutional. So in a way it's the final barrier that
prevents any legislators from getting too crazy or racist in the laws
they pass.
But the Supreme Court itself is not made up of gods or wizards. They
are just people, with agendas. And sometimes they have rendered opinions
that make you wonder if the whole legal system isn't just full of crazy
people from the top down. For instance, the court has ruled ...

#5. A Business Can Kick You Out of Your House if It Wants to Build There

#4. Scientists Can Create Life (And Corporations Can Own It)

#3. You Can Imprison an Entire Race, if


12. The vacuum pump 15 is then operated to decompress the chamber 1, to promote evaporation (drying) of the solvent in the coating solution, evaporating solvent components forming an exhaust stream spreading outwardly from between the wafer W and the diffuser plate 16. Polyimide components remaining on the wafer W is turned into a coating film thereon.
Discussed below are several drawbacks of such known drying mechanism.
Firstly, a solvent evaporation speed could depend on the difference in density of solvent contained in a coating solution and gaseous solvent near the surface of the coating solution. The larger the density difference, the higher the evaporation speed.
Solvent components evaporating from the coating solution will be formed into a stream flowing outwardly along the wafer surface with the help of the diffuserand Lisa think, she discovers that they agree with their dad's assessment about he, and even bring up times that prove that all Marge really does is ruin everyone's fun by nagging at them. Marge becomes uncomfortable and offended after discovering that people see her that way and goes to the Spinster City Apartments (almost hitting Ned Flanders with her car on the way out). While Marge is at Spinster City, Patty and Selma introduce Marge to an infomercial featuring self-help guru, Brad Goodman, who can supposedly help people like Marge with their "chronic nagging."

After Marge makes Homer watch a Brad Goodman video with her, she becomes more tolerant and the two start getting along better. After seeing how out of control Bart is, the family goes to


choose to blame Bart for the mess (though Rev. Lovejoy pointed out that Brad Goodman was the one who inspired the town to act like Bart in the first place). They form a mob to attack him, but Homer rescues him in a parade float. The crowd almost immediately gives up the chase, despite the float's very slow speed, and goes to the old mill to get some cider.

Back home, the Simpsons discuss what they have learned. Homer feels that Bart should have been a better role model, but Marge comes to Bart's defense by claiming that self-improvement is best left to people who live in big cities. But Lisa claims that the actual lesson is that self-improvement can be accomplished, but through hard work and not a{#sec2.1}
---------------------------------------------------

The study was performed in accordance with the National Institutes of Health guidelines for the care and use of experimental animals and with the approval of the Animal Care Committee of the Canton of Berne, Switzerland. Here, we present data from a subset of animals from two previous publications, where effects of fluid resuscitation on mortality and organ function in sepsis \[[@B16]\] and oxygen transport and mitochondrial function in shock models \[[@B17]\] were investigated.

24 pigs (median body weight 41 kg, range 38--44 kg) were deprived of food but not water 24 hrs before the experiment. They were premedicated with atropine 0.05 mg/kg of body weight, azaperone 6 xylazine 2 mg/kg, and ketamine 20 mg/kg intramuscularly, followed by cannulation of an ear vein and intravenous administration of 5--15 mg/kg pentobarbital and atropine 0.05 mg/kg followed by tracheal


intubation. Anesthesia was maintained with pentobarbital 7 mg/kg hour and fentanyl 25 *μ*g/kg hour until the end of the operation and thereafter 3 *μ*g/kg hour. The animals were ventilated with a volume controlled ventilator with 5 cm of H~2~O end-expiratory pressure. FIO~2~ was adjusted to keep paO~2~ between 100 mm Hg and 150 mm Hg. Tidal volume was kept at 10 mL/kg, and the minute ventilation was adjusted to maintain paCO~2~ between 35 and 40 mm Hg. A pulmonary artery catheter and a femoral arterial catheter were inserted. Ringer\'s lactate was infused at 10 mL/kg hour. Additional fluid was administered if necessary to keep pulmonary capillary wedge pressure between 5 and 8 mm Hg. The aim was to keep the body temperature at 38 ± 0.5°C using and operating table heater and warmed fluids if necessary.

2.2. Surgical Preparation {#sec2.2}
-------------------------

The carotid artery washepatic vein catheter was inserted, and the location of the tip was confirmed by ultrasound and oxygen vein saturation. The catheter was withdrawn 0.5 cm from the wedged position to allow measurement of hepatic venous pressure and saturation. A central venous catheter was inserted into the pericardial space via dissection of the left diaphragm. Before closing the laparotomy with clamps, two large bore tubes were placed with their tips in the peritoneal cavity to allow later insertion of autologous feces.

2.3. Hemodynamic Monitoring {#sec2.3}
---------------------------

Femoral and pulmonary arterial, central, hepatic, and portal venous blood pressures and pulmonary artery occlusion pressure were recorded with quartz pressure transducers and displayed continuously on a multimodular monitor (S/5 Compact Critical Care monitor, GE, Helsinki, Finland) and recorded. All pressure transducers were zeroed to the level


and that it was not a defense to show that the defendant entered the premises before the plaintiff took title. (Mapes, 238 Ill. at 144; see also Chicago & Iowa R.R. Co. v. Hopkins (1878), 90 Ill. 316, 321 (purchaser could have maintained ejectment action against defendant railroad where defendant had no legal right to occupy premises).) In view of these holdings and the language of section 6-119, plaintiff's ejectment action was properly brought even though he did not acquire an interest in the property until after defendant's original entry.
 2 Defendant's second argument is that judgment was improperly entered for plaintiff because plaintiff failed to contradict defendant's assertion that the sewer was lawfully placed on plaintiff's property. Defendant claims that the property owner at the time theproperty at the time the initial entry was made and that plaintiff has not shown the original entry was unlawful. Once again, defendant's arguments are not convincing.
 5 If a trespass is continuing, any person in possession of the land at any time during its continuance may maintain an action for *436 trespass. (Lake Shore Building Co. v. City of Chicago (1917), 207 Ill. App. 244, 247-49.) In Lake Shore, as in this case, the defendant constructed a pipeline under the plaintiff's property prior to the plaintiff acquiring title. When the plaintiff acquired title, it brought suit in trespass, and judgment was entered for the plaintiff. The court termed the trespass a continuing one and specifically rejected the argument that the right of action existed only in the


the license or consent is on the defendant. (Milton v. Puffer (1911), 207 Mass. 416, 93 N.E. 634; 75 Am.Jur.2d Trespass § 79 (1974).) Since defendant has not been able to show that any prior owner consented to the placement of the sewer here, summary judgment for plaintiff on the trespass claim was proper.
Defendant next argues that the trial court erred in granting the writ of mandamus compelling defendant to institute eminent domain proceedings. Defendant argues that plaintiff failed to demonstrate a clear right to the remedy because plaintiff did not establish that the sewer effectively destroyed or impaired the usefulness of his land and because, if there was any taking, it was not from plaintiff but from the owner at the time the sewer was installed.
*437 and "1st New" to arrive at another new RNG (say "2nd New").
And I continue with the same on subsequent visitors until a certain duration is reached, to arrive at a final RNG (say "Final New").
Is this "Final New" almost as good as TRNG?
Or is it at least as good as CSPRNG?
For a hacker to successfully brute force my RNG, he needs to know the specific IP addresses of my visitors, at certain time period when a particular (unknown) action is executed, per each different visitor, for a duration of time, and the logic used in computing the RNG from one visitor with the next.

A:

Is this "Final New" almost as good as TRNG [or CSPRNG]?

Assuming proper cryptographic techniques for entropy combination (eg Fortuna or at least hashing) are used


Bloomberg, told Matthews that President Trump’s statements would have been met with scorn from conservatives if former President Barack Obama had uttered them. “I think President Trump is doing this on a level that would make a lot of Republicans nervous,” he speculated.

Turning his attention to President Trump’s supporters, Matthews criticized rally attendees for cheering proposals aimed at giving NATO allies more responsibility of their own security concerns. “They’re not getting paid. They’re not running for anything. Those regular people that show up for a Trump rally are cheering the attacks on our European allies and cheering ‘give a chance to little Putin,’” he complained.

Over breakfast in Brussels with NATO Secretary-General Jens Stoltenberg on Wednesday, President Trump lamented how the Nord Stream 2 gas pipeline may leave Germanyand SS in the outflow was about 16.01, 4.27 and 4.01 mg/L respectively and the concentration of NH4(+) -N and TP in the outflow was below 9.72 and 0.45 mg/L respectively. The subsurface wetland with two stages can overcome the disadvantage of the single system and improve the pollution removal efficiency.


a Gaussian distribution with center $\mu_k$ and Covariance ${\bf C}_k$, with $k=1,...,K$, i.e., thus the probability of $p_i$ given class k is the following:

$$P(p_{i}|k, \mu_k, {\bf C}_k)=\frac{1}{Z_k} \,  \,  e^{- \, \frac{1}{2} \, (p_i -\mu_k)\, {\bf C}_k^{-1} \, (p_i-\mu_k) }\, .$$ where $Z_k= (2\, \pi)^{d/2} \, |{\bf C}_k|^{1/2}$ is a normalization factor with $ |{\bf C}_k|^{1/2}= \sqrt{det\, {\bf C}_k}$ and $d$ is the data dimensionality.

Suppose from the set of $N$ points originated from $K$ classes, there are $N_k$ points per class ($N=\sum_{k=1}^{K} N_k$). Since $N_k$ is assumed to be unknown, according to the Gaussian mixture method, the final distribution is given by a weighted sum of each class distribution of all $N$ points

$$\begin{aligned}
P(p_i|\{\theta_k\}) &= & \sum_{k=1}^{K} P(p_i, k|\{\theta_k\})= \sum_{k=1}^{K} P(k|\{\theta_k\}) \, P(p_i|k, \{\theta_k\})
\nonumber \\
&=&\sum_{k=1}^{K}\left[   \frac{  o_i }{\left [ 2\, \alpha{2}^2 \,  G_{i,2}^2
 +  \,  (\alpha\, o)_i \right ]}
 \nonumber \\
 && {\rm applying\, equation } \ref{eq:E-quantum-step-two-nocos}
 \nonumber \\
 &=& \sum_{i}^{N}  \frac{  \left ( G_{i,1}^2 \,  -\,o_i\right ) }{\left [ \alpha_{1}^2 \,  G_{i,1}^2
 +  \alpha_{2}^2 \,  G_{i,2}^2
 + \, (\alpha\, o)_i  \right ]}
\label{eq:copy-alpha1} \\
\nonumber \\
 {\rm for} & \partial_{\alpha_{2}}&
 {\rm derived \, in \, } \ref{eq:alpha2}
\nonumber \\
0 &= &    \sum_{i}^{N} -\, Q_{i,1}^{t} \,  \frac{  o_i  }{\left [ 2\, \alpha_{1}^2 \,  G_{i,1}^2
 +  \,  (\alpha\, o)_i \right ]}
 + Q_{i,2}^{t}\,\frac{   \left (  2 \,   G_{i,2}^2 \,-


N1 = 500, and N2 = 1000. For cases A and B, $\mu^2$ was fixed to 5, and for cases C and D, $\mu^2$ was fixed to 9. The table above specifies the original/true objective function, which is higher than the ones for the quantum case, due to the interference phenomena. The objective function for the final values is lower than the original/true objective function, which means the method is performing adequately. ](Figures/Classical_landscapes.png){width="\linewidth"}

Estimated Values for Classical Method\

Deformations to the Gaussian Assumption {#sec:Deformations-Gaussians}
---------------------------------------

So far, the tested classes were generated from Gaussian distributions. Now, in order to deform the shape of the distribution, the data set is initially drawn from a Gaussian distribution and then, each point coordinates is displaced by a random number drawn from a uniform distribution inThis allowed the quantum method to produce much more accurate and robust solutions, compared to the classical method.

For working towards segmentation, clustering may also be interpreted in a Bayesian method as the data likelihood model and combined with the prior model on the data (such as encouraging neighbors to be labeled similarly) to form the posterior probability. In this case, for the future, once the clustering model is produced, techniques such as graph cuts[@Ishikawa1998; @Boykov2001] could be employed to yield final and better results for color segmentation.

Gradient Equations For the Parameters {#sec:gradient}
=====================================

$\alpha_{k}$: $$\begin{aligned}
 {\rm for} & \partial_{\alpha_{1}}&
\nonumber \\
0 &=& \sum_{i}^{N}Q_{i,1}^{t} \,  \frac{  \left ( 2 \,   G_{i,1}^2 \,  -\,\frac{G_{i,1} \, G_{i,2}}{ \sum_i G_{i,1} \, G_{i,2}}\right ) }{\left [ 2\, \alpha_{1}^2 \,


to compare DES with encryption algorithms like AES?
Not really. AES (First published in 1998) came around and about 20 years later than DES (First published in 1975, standardized in January 1979). In those 2 decades, both hardware as well as software evolved… and the creators of AES surely had the benefit of being able to look back at DES and its issues (both in relation to cryptanalysis as well as in relation to different implementations).
Is it fair to compare DES with hashing algorithms like SHA2?
Same as before: not really. SHA2 (First published in 2001) benefitted from similar things like AES. While we now may have access to cool things like personal computers et al, things looked quite different back in the 70´s… not only from aBackground {#Sec1}
==========

Non-Negative Matrix Factorization (NMF) is a very efficient approach to feature extraction in machine learning when the data is naturaly non-negative. It has been applied to an extremely large range of situations such as clustering \[[@CR1]\], email surveillance \[[@CR2]\], hyperspectral image analysis \[[@CR3]\], face recognition \[[@CR4]\], blind source separation \[[@CR5]\], etc. It has recently also been applied to microarray data analysis \[[@CR6]\] and biomedicine \[[@CR7]\]. Given a dataset consisting of *n* vectors *x*~1~,...,*x*~*n*~ in $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}
                \usepackage{amsfonts}


    \begin{document} $$ M \,\, = \,\, UV^{t}+E, $$ \end{document}$$ where *E* is an error term, *U* and *V* are componentwise non-negative, and *U* has a small number of columns. The features are the columns of *U*. They are often interpretable and summarize the data in an efficient manner since each data then consists of a mixture of these columns. For many real datasets, the rank of the obtained matrix, i.e. the number of features extracted, is usually small and the NMF thus provides a compact representation of the data.

The method was first explored by Lee and Seung \[[@CR8]\] in the late 90's and it then enjoyed a significant growth of interest in many application fields and especially machine learning. There exists a wide varietyarticle \[[@CR15]\], whereas gene expression dataset are often corrupted by very large noise. This is easily overcome by performing least squares penalized estimation as in e.g. the code GoDec \[[@CR16]\]. In the present work, an efficient method is proposed that denoises the data, estimates the missing values, and identifies the outliers in *M* via non-negative low-rank + sparse + noise matrix factorization. Our algorithm is inspired by the recent work \[[@CR17]\], which presents a clear interpretation of the ADMM in terms of proximal method-type iterations. In our approach, a Bregman divergence is chosen for the proximal scheme which allows to easily take into account the nonnegativity constraints.

In the next section, the Bregman proximal scheme is presented and in the subsequent Section, a version taking into account potential outliers


   \usepackage{amsbsy}
                \usepackage{mathrsfs}
                \usepackage{upgreek}
                \setlength{\oddsidemargin}{-69pt}
                \begin{document} $$ \begin{aligned} {}\text{argmin}_{U\in \mathbb R^{d\times r}} \ \frac{1}{2}\left\|M-UV^{(k)^{t}t}\right\|_{F}^{2}&+\rho \left(U^{(k)} \ln\left(\frac{U}{U^{(k)}}\right)\right.\\ &-\left.\left(U-U^{(k)}\right)\right). \end{aligned}  $$ \end{document}$$

The gradient of *ϕ*(*U*) is given by $$\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}
      \usepackage{wasysym}
                \usepackage{amsfonts}
                \usepackage{amssymb}
                \usepackage{amsbsy}
                \usepackage{mathrsfs}
                \usepackage{upgreek}
                \setlength{\oddsidemargin}{-69pt}
                \begin{document}$\forall \: l \in \mathbb {N}^{*}$\end{document}$, define $$\documentclass[12pt]{minimal}


   \setlength{\oddsidemargin}{-69pt}
                \begin{document}$U^{(k)}V^{(k)^{t}}\phantom {\dot {i}\!}$\end{document}$ as a function of iteration numberFig. 5Cluster index for each group of patients. Subplot 1 corresponds to pTa, subplot 2 to pT1a, subplot 3 to pT1b, and subplot 4 to \> pT1

The first subplot of Fig. [4](#Fig4){ref-type="fig"} represents the matrix *S* after convergence, while the second subplot is the matrix *V*^*t*^. The third subplot, for its part, represents the distance in Frobenius norm between two successive iterates of *Λ*. Finally, the fourth subplot represents the evolution of the relative error between *M* and its NMF $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
    neuroprotective and anti-ageing effects via the activation of lysosomal mucolipin TRP channels, independent of mTOR \[[@B98-cells-09-00671]\]. Moreover, rapamycin, the US Food and Drug Administration-approved mTOR inhibitor, has been shown to extend the median and maximal lifespans of both male and female genetically heterogeneous mice \[[@B99-cells-09-00671]\]. Twenty-four-month-old female C57BL/6J mice treated with rapamycin for 3 months present improved late-life vascular contractile function and antihypertrophic signaling in the aged heart with remission in age-associated inflammation. Rapamycin treatment also results in beneficial behavioral, skeletal and motor changes in old mice \[[@B100-cells-09-00671]\]. A phase 2a clinical study with a low-dose combination of a catalytic (BEZ235) plus an allosteric (RAD001) mTOR inhibitor that selectively inhibits mTOR downstream target of rapamycin complex 1 (TORC1) for 6 weeks demonstrates that mTOR inhibitor therapy is safe,


was undertaken since 2015 \[[@B111-cells-09-00671]\]. Another phase 4 clinical study (NCT02915198) investigating the outcome of metformin in patients with pre-diabetes and established atherosclerotic cardiovascular disease started in February 2019. The recent multicenter trial "Targeting Ageing with Metformin (TAME)" focusing on targeting ageing and chronic conditions may be supported by NIH in the future \[[@B112-cells-09-00671]\]. Given the uncertain side effects (vitamin B12 deficiency, lactic acidosis and gastrointestinal side effects) of metformin presenting in some individuals \[[@B104-cells-09-00671]\], personal metformin therapy for anti-ageing may demand more in-depth study.

In addition, β-hydroxybutyrate (β-HB) may mediate the effect of a ketogenic diet \[[@B113-cells-09-00671],[@B114-cells-09-00671]\], intermittent fasting \[[@B115-cells-09-00671]\] or exercise \[[@B116-cells-09-00671]\] on healthspan extension or neuroregeneration because of its anti-inflammation \[[@B117-cells-09-00671]\], inhibition of vascular cell senescence \[[@B118-cells-09-00671]\] or immune activation by the formation and maintenance ofimmune cells, plays a critical role in the eradication of senescent cells at a young stage or under physiological conditions. Although senescent cells can be induced to undergo apoptosis by senolytics \[[@B45-cells-09-00671],[@B60-cells-09-00671],[@B78-cells-09-00671],[@B81-cells-09-00671],[@B120-cells-09-00671]\], these apoptotic cells must be finally cleared by the immune system. Interaction between senescent and immune cells affects immune system function. Senescent cells recruit and make immune cells senescent and dysfunctional via SASP, leading to persistent and excessive accumulation of senescent cells \[[@B122-cells-09-00671]\]. However, the precise mechanism underlying senescent cell accumulation within tissues is still debatable. It is unknown whether this is due to senescent cell increase exceeding the immune system's ability to clear them or immune cell dysfunction.

3.1. Maintenance of Immune System Function to Keep Healthy Longevity {#sec3dot1-cells-09-00671}
--------------------------------------------------------------------

A study investigating human ageing at the individual


dermal fibroblasts and endothelial cells express higher levels of the atypical major histocompatibility complex (MHC) Ib molecule HLA-E via the p38 signaling pathway than non-senescent cells. HLA-E expression is also increased in the senescent fibroblasts of human skin during ageing. HLA-E then inhibits immune cytotoxicity targeting senescent cells by interacting with the inhibitory receptor NKG2A expressed on NK cells \[[@B124-cells-09-00671]\]. However, p53-expressing senescent liver tumor cells recruit NK cells by inducing the chemokine CCL2 but not CCL3, CCL4 or CCL5, in senescent tumor cells without affecting the ligand expression of RAE-1 proteins in the tumor cells \[[@B153-cells-09-00671]\]. Collectively, agents blocking the interaction between HLA-E and NKG2A \[[@B124-cells-09-00671]\], the humanized anti-NKG2A monoclonal antibody monalizumab \[[@B154-cells-09-00671]\] and NKG2A protein expression blockers \[[@B155-cells-09-00671]\] would be promising strategies for the immune clearanceserial- and USB-enabled sensors. Thus far, monitoring capabilities of the HHH via wireless devices include blood pressure, weight, physical activity, photo/video, environmental tobacco smoke, and medication adherence via "smart pill bottles."The HHH enables two-way communication between patients and researchers through audio and video feeds and can support interfaces such as touch-screens on which questionnaires for self-report data can be displayed. CYCORE collects data in sensor streams that are compatible with those from other data sources important to cancer CER, such as clinical records and lab data. Within the last 18 months, there has been a rapid increase in the range and extent of inexpensive sensors of all types that can be deployed via wireless connection to the HHH. Also, several systems that have some of the features of the


the complexities inherent in the prevention and treatment of cancer. To be most meaningful, questions in CER should be informed by not only medical and clinical data but data from other domains critical to health such as behaviors and the everyday experiences of individuals in their home environment. Subsequent reports from this project will provide further insight into how to accomplish this and should guide others as they endeavor to translate research into practice and improve patient and population-level outcomes.

**Implications**

**Practice:** Clinicians will find decision-making easier and more effective for the patients because new variables can be taken into account, including those arising from individual differences. A physician can then prescribe treatment regimens with more confidence of positive outcomes.

**Policy:** The information gleaned from better-supported CER studies can be used toor entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

***Financial support.*** This work was funded by the Veteran\'s Affairs Medical Center, grant number 1IK2CX000611 (to M. T. M.) and the Defense Advanced Research Projects Agency, grant number lN66001-07-C-0092 (to G. S. G. and C. W. W.).

***Potential conflicts of interest.*** M. T. M., E. T., G. S. G., A. K. Z., and C. W. W. have patents pending on host-based diagnostics for pathogen identification. G. S. G., E. T., and C. W. W. receive funding from Novartis to develop novel biomarkers for infectious disease. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content


Woburn Resources across the site

Cancer Clusters: Fact or Fiction?

Overview

The Woburn trial focused on a suspected childhood leukemia cluster and its connection to toxic pollutants TCE and PCE in the city's municipal water supply. This webpage includes background information on cancer clusters, as defined by Centers for Disease Control, and specific information on cancer clusters related to the Woburn trial.

What is a Cancer Cluster?

Cases of childhood leukemia identified by citizens of For A Cleaner Environment

A disease cluster occurs when a greater than expected number of people become ill with the same disease in a given geographic area, a group of people, or a period of time. When this disease is the same form of cancer, it is called a "cancer cluster". The Centers for Disease Control have specific definitionsconsumption of peanut butter, crisp bacon, etc.

The plaintiffs put more emphasis on the validity of the medical science that formed the basis of the Massachusetts Health Department report. Their efforts centered on bolstering the validity of the epidemiological studies using statistics. At the time of the trial, experts agreed there were no definitive causes for the types of leukemia.

Mock Trial Activities Related to Cancer Clusters

Difficulties in Identifying Cancer Clusters

Difficulties in confirming cancer clusters include:

Difficulties in obtaining data. People change residences and it can be difficult for epidemiologists to identify previous exposures and find the records that are needed to determine the kind of cancer a person contracted, or if it was cancer at all. In addition, cancer may take years to develop after exposure to a cancer causing


America's fascination with gang violence in Compton that the films started playing in Peoria.

Despite the contradictions between the public perception of violence in movies and murda music that some Hip Hop fans attempt to expose, there is a difference.

First, there aren't thousands of people across the country walkin' the streets dressed like Dr. Doom but you can go to any 'hood in the USA and see kids lookin' like clones of their favorite rappers with artist "Cash Out " braggin' about "ridin' around with that nina (nine millimeter) " blastin' thru their Beats by Dre headphones.

Secondly, we still live in a world where the young Black male is the usual suspect. Just ask the brotha sitting on death row because of a case of "they-all-look- a-like mistaken identity."normal everyday thing.

Back in '92 DJ Quik asked on "Just Lyke Compton," "how could a bunch of suckas in a town like this have such a big influence on brothas so far away?" In retrospect the song seems like a spooky premonition of how gangsta rap was going to impact the world.

But since 99% of the violence in rap music is Black on Black, few folks outside the 'hood seem to care. Out of site; out of mind.

If there is any common denominator between rap music and the murders in Aurora it would be that the movies' maker Warner Brothers also makes Hip Hop music. While the company cannot control the actions of very sicko with a gun who decides to shoot up a theatre showing one of


details.
 *
 * You should have received a copy of the GNU Lesser General Public
 * License along with this software; if not, write to the Free
 * Software Foundation, Inc., 51 Franklin St, Fifth Floor, Boston, MA
 * 02110-1301 USA, or see the FSF site: http://www.fsf.org.
 */

package org.jboss.as.clustering.infinispan.subsystem.remote;

import org.jboss.as.clustering.controller.ManagementResourceRegistration;
import org.jboss.as.clustering.controller.ResourceDescriptor;
import org.jboss.as.clustering.controller.SimpleResourceRegistration;
import org.jboss.as.controller.ModelVersion;
import org.jboss.as.controller.PathElement;
import org.jboss.as.controller.transform.description.ResourceTransformationDescriptionBuilder;

/**
 * /subsystem=infinispan/remote-cache-container=X/near-cache=none
 *
 * @author Radoslav Husar
 */
@Deprecated
public class NoNearCacheResourceDefinition extends NearCacheResourceDefinition {

    static final PathElement PATH = pathElement("none");

    static void buildTransformation(ModelVersion version, ResourceTransformationDescriptionBuilder builder) {
        // Nothing to transform yet
    }

    public NoNearCacheResourceDefinition() {
        super(PATH);
    }

    @Override
   to improve the ability of the model to simulate the system over time (i.e. calibrate to temporal data). 5) The resulting optimized model retains much of the structure of the initial model.](pcbi.1002722.g001){#pcbi-1002722-g001}

Results {#s2}
=======

Model data {#s2a}
----------

Gene expression data obtained from microarrays (Affymetrix) run on mouse blood was utilized for this study (see [Methods](#s4){ref-type="sec"}). The mice were treated with one of three different preconditioning stimuli: lipopolysaccharide (LPS), CpG-oligonucleotide (ODN), or brief ischemia (15 minute stroke); or treated with saline or a sham surgical procedure as controls. These preconditioning stimuli provide the brain with a defined window of protection against cerebral ischemia. The protection requires time to develop prior to the ischemic event to allow for the necessary new gene expression and protein synthesis to develop. In this model, the preconditioning


of this kind of model is that the expression levels of the input regulatory influences must be measured for every time point in order to be able to make predictions. Our dynamic model only requires specification of the initial state to simulate the subsequent time steps, potentially for a broad range of different initial conditions.

Dynamic simulation of expression levels using an inferred model {#s2d}
---------------------------------------------------------------

We were interested in determining if the initial steady-state model generated by the Inferelator could be used as the basis for dynamic simulation to describe how the expression levels of all clusters in the model change over time. Accordingly we transformed the model into a matrix of coefficients in which the rows refer to regulatory influences and the columns refer to their targets. This matrixperformance of the dynamic model using parameters derived by Inferelator 1.1 was moderate, we were interested in determining if the model contained useful information, in the form of its coefficients and/or structure that could be used as a basis for further dynamic model development. Two aspects of the model are critical in determining how accurately it simulated temporal profiles: its structure in terms of the pattern of regulatory influences between clusters, and the coefficients of each of these regulatory influences that form the system of ODEs. We investigated the information content of the coefficients of the model as well as the structure of the model by performing several different randomizations of the existing model. We first preserved the structure of the model but perturbed the coefficients for each


(uniform), or the locations of all values in the matrix were reassigned (scramble). The results (as a box and whiskers plot) show that the optimized model is capable of simulation over time with a performance that is significantly better than randomized versions.](pcbi.1002722.g005){#pcbi-1002722-g005}

The expression patterns predicted by the LPS-optimized model are shown in [Figure 6](#pcbi-1002722-g006){ref-type="fig"}. For each cluster with more than five genes we show the observed (black line), predicted (green line), and random (red line) expression patterns for the LPS time course. For the random prediction we show the average prediction from 25 randomly restructured models (coefficients randomized in the model). These results show that the model can do quite well at recreating many of the patterns of expression of the time course on which it was optimized.

![Expressionmodel construction will be to consider the disruption in the model explicitly.

The time course experiments used in this analysis all had five time points. This is a limited number of points to parameterize the relationships between 25 clusters. Combining networks to create injurious and protected networks alleviates this limitation to a certain extent in terms of confident regulatory relationships, but the resulting models should be considered to be underdetermined. Including more data points in these models will be necessary to strengthen these models. Finally, a significant limitation of our models is that the clusters used as functional modules are still quite large and are likely to perform multiple functions. This fact prevents inference of mechanistic relationships between regulators and functional processes and pathways that would be desirable for


LPS, CpG-ODN, and brief ischemic preconditioning but has low predictive values for saline and sham ([Table 2](#pcbi-1002722-t002){ref-type="table"}; [Figure S3](#pcbi.1002722.s004){ref-type="supplementary-material"}). Preconditioning with LPS, CpG-ODN, or brief ischemia all provide protection against the cerebral ischemic event in this model while the saline treatment leads to significantly worse damage. Evidence strongly indicates that these preconditioning paradigms alter the gene regulation that occurs prior to and following stroke to promote neuroprotection [@pcbi.1002722-StenzelPoore1], [@pcbi.1002722-Marsh1], [@pcbi.1002722-Stevens2]. Thus, the clusters that are most predictive for all three preconditioning paradigms may reveal gene regulation that is important for neuroprotection. Clusters 14 and 15 functionally represent genes related to inflammation and apoptosis. Cluster 14 contains the gene tumor necrosis factor alpha (TNFα), which is a gene that is critical to preconditioning-induced protection. This is demonstrated by theobtained from a transcriptional study of a mouse model of neuroprotection during stroke [@pcbi.1002722-Stevens1]. The dataset used for modeling is the accompanying blood samples from the previously published brain transcriptional analysis [@pcbi.1002722-Stevens1]. In brief, groups of C57BL/6 mice (n = 4/treatment/time) received either preconditioning alone, preconditioning plus injurious ischemia (45 min MCAO), or injurious ischemia alone. Preconditioning paradigms included: LPS (0.2 mg/kg; i.p.), CpG (0.8 mg/kg; i.p.), saline (i.p.), short-term MCAO (12 min), or sham MCAO (12 min). For groups receiving preconditioning alone, mice were euthanized at 3, 24 or 72 hr post preconditioning. In groups receiving preconditioning plus injurious ischemia, MCAO was performed 72 hr following the preconditioning stimulus and mice were euthanized at either 3 or 24 hr post occlusion. Six untreated mice were included as a baseline


the Inferelator allows use of non-linear combinations of regulatory influences in the inference process, we did not consider these in our model to allow the treatment of the resulting model as a linear system of coupled ODEs. The performance of the model was evaluated by constructing five independent models, each leaving one time course out for evaluation as previously described [@pcbi.1002722-McDermott1]. The performance results were calculated as the mean of performance results for each cluster, normalized by the number of genes in that cluster [@pcbi.1002722-McDermott1]. This initial model requires that the expression levels of the input regulatory influences, in this case other clusters, are known and that these can be combined to provide a predicted expression pattern for the target cluster.

To derive an initial model for dynamic simulationsthe coefficients for each regulatory influence were averaged over each of the five evaluation models, and those influences that were inferred in fewer than three models were excluded. Regulatory influences with coefficients having an absolute value less than 0.1 were also excluded. This eliminates regulatory influences with low impact on the final model and limits the final number of regulatory influences in the model.

Dynamic simulations {#s4d}
-------------------

Our main model for the time evolution of gene cluster expression can be described as follows. Suppose we have *N~c~* clusters, and let *c~i~* represent the mean expression level of cluster *i* for . Our model equations are:where *τ~i~* is a cluster expression decay constant and is the sum of weights for the influence of all regulators in cluster *l* on cluster *i*.


of adding an influence in a location that had previously been 0 was set to 0.1%, and the probability of removing a non-zero influence was set to 1%. Aside from these exceptions perturbations were only allowed for non-zero values in the matrix. This first stage provided a set of optimized models with high heterogeneity to explore the variable space around the initial matrix. The matrix producing the best performance in the first stage was chosen to serve as the initial matrix for the second stage of optimization.

The second stage of optimization was performed in the same manner as the first to generate 25 additional models, but was allowed to proceed for 25000 steps. The initial probability of accepting deleterious perturbations was set to 10%, with all other parametersof times an edge appears in the 25 models from the LPS-optimized ensemble is shown as a histogram.

(PDF)

######

Click here for additional data file.

######

**Edge consistency in model ensemble.** Clusters containing more than 5 genes are shown (green squares) as determined by our functional clustering approach. The influences between clusters are shown as directed edges with arrows indicating a positive influence (activation) and T lines indicating a negative influence (repression). Line coloring indicates the number of models in the LPS-optimized ensemble that the edge appears in, grey edges are not present in the LPS-optimized model but were present in the original model.

(PDF)

######

Click here for additional data file.

######

**Cross-prediction plots for the LPS-optimized model.** Relative expression levels (log~2~ fold change expression) are plotted over time (X axis) for


as the sample from individual VI:2. This revealed a lack of reads (average 0.56 reads/base) in exon 6 of the *AMBN* gene (NM_016519), compared with an average of 230 reads/base (range 200--269) in the five comparison exomes. Investigation of the remaining exons of *AMBN* revealed that read depth for these exons in individual VI:2 was similar to that in comparison exomes.

PCR and sanger sequencing {#s2c}
-------------------------

To investigate the lack of reads further, PCR amplification using primers designed to amplify exon 6, plus 50 bp of flanking intron, was performed. The results corroborated the exome data in that no product was observed in the affected members of the family, whereas amplification was successful in unaffected family members. A control PCR, designed to amplify part of the *P53* gene, was successfulterms of thickness and mineral density \[density = 2.82 g ± 0.073 g/cm^3^ compared with 2.69--2.92 g/cm^3^---the range previously reported for deciduous enamel ([@DDU247C26])\] consistent with originating from either individual V:I or VI:6 (both normal genotype). The enamel covering teeth 2 and 3 was pitted and varied in thickness over the crown from near normal to areas where thickness was reduced to tens of microns and in some places was absent altogether. The enamel covering teeth 4 and 5 was thinner (∼50 µm or less) or absent to a greater degree than in teeth 2 and 3. Mean mineral density was significantly reduced in teeth 2--5 relative to tooth 1 (Fig. [3](#DDU247F3){ref-type="fig"}). Figure 3.High resolution X-ray CT analysis of exfoliated teeth **1--5**. Typical CT sections through the teeth are presented


using false colour calibrated with respect to mineral density to generate mineral density maps. Mean enamel mineral density for each tooth is also shown graphically. Tooth 1 exhibits an enamel layer apparently normal in structure and density. Teeth 2 and 3 exhibit an obvious enamel covering though it is thinner in many areas, chipped, absent in places and is significantly reduced in mineral density compared with tooth 1 (*P* \< 0.0001). Teeth 4 and 5 exhibit an even thinner covering of enamel with enamel absent in some areas. Again enamel mineral density is significantly lower than in tooth 1 (*P* \< 0.0001). The only non-significant differences in enamel mineral density occur between teeth 4 and 5. Videos of 3D rendered CT data showing surface detail and internal structureThe “hack-proof vest” placed on the top of ILCoin’s SHA-256 algorithm allows blocking different types of activities and prevents blockchain corruption, such as double spending and rollbacks.

The project notes that C2P is certified by a third party, an official partner of cybersecurity company Palo Alto Networks.

ILCoin is available here

From the past to the future

The project was launched in January 2015, before the rise of bitcoin. During the next two years, the team worked on the source code, improving its security and developing online crypto wallets.

The major progress has been made during the last year and a half. Since November 2017, the company released a new version of its Android wallet, web wallet and block explorer, which enables ILCoin holders to monitor their transactions. The startup also launched its


opinions of the doc. Watch the video below to see what we thought! Feel free to comment or send your thoughts to creatingdialogue@gmail.com !

Now that Prom Season is officially over and our Prom Dress Drive 2013 tour has come to an end, we want to thank all of you that helped donate, sponsor, and encourage us through such a busy and exciting time. We were able to help over 20 families and teens cut down on the expensive prom costs so that this night could truly be memorable! Special thanks to all of our hair salons and make-up artists who donated their services as well!

See some of the photos & student testimonials below! Click the images for full slide show!

On Tuesday, March 26, 2013 at 12:00 noon thelagoons for the collection of the waste. In the barns or houses, the animals live on elevated flooring which permits the feces to drop through the floor to a sub-floor. This sub-floor is periodically flushed to remove the feces and maintain a healthy living environment. The feces with the wash down water as a vehicle flow to the storage lagoon.
A properly operated lagoon will biologically decompose a significant amount of the animal waste. However, large amount production operations require proportionately large lagoons and therefore a significant amount of land is consumed. Also, the two major components of animal waste that are regulated, mainly nitrogen and phosphorous, are not significantly removed by a stagnant lagoon or pond.
When the lagoon-treated waste is applied to the crop land it contains high