Introduction {#s1}
============

Smallpox was officially declared eradicated by the World Health Organization in 1980, and routine vaccination against smallpox no longer recommended except for select groups (e.g., laboratory workers working with poxviruses) \[[@B1]\]. While variola virus, the causative agent of smallpox, is officially retained at two World Health Organization (WHO) collaborative centers: The Centers for Disease Control and Prevention, Atlanta, Georgia, United States, and The State Research Center of Virology and Biotechnology, Novosibirsk, Russia, it is not known with certainty whether there exist other undeclared sources of the virus \[[@B2]\]. Thus, there remains some concern of a possible re-emergence of smallpox due to an inadvertent release of variola from the laboratory or from deliberate use of the virus as a bioweapon. In addition, a number of orthopoxviruses that infectof Health (NIH), and were routinely used to determine vaccinia virus titer.

A clonal isolate of vaccinia virus, DV-3, was isolated by plaque purification from the Dryvax virus seed stock described previously \[[@B21]\]. DV-3 was prepared from infected BSC-1 cells and virus titer was determined using BSC-40 cells. Vaccinia virus strains WR and IHD-J, as well as recombinants WR-luc and IHDJ-luc, were prepared from infected BSC-40 cells as previously described \[[@B22],[@B23]\]

Plaque Assay and Immunostaining {#s2.3}
-------------------------------

Confluent monolayers of BSC-40 cells in 6-well tissue culture plates were infected with diluted virus suspensions. Control wells were mock-infected with DMEM medium. After 2 hours of incubation at 37 ^°^C, an overlay of 2 ml growth medium containing 0.5% carboxymethyl cellulose (CMC) was added to each well, and plates were re-incubated for 2 to


7 days (as necessary, depending on the virus). For crystal violet staining, the CMC overlay was aspirated and a solution of 0.5% crystal violet containing 25% formalin (fixative) was added to each well. After 30 minutes of staining, plates were rinsed with water to reveal plaques.

For detection of plaques by immunostaining, cells were rinsed with PBS after the removal of the CMC overlay, and fixed with a cold solution of acetone/methanol (1:1) for 10 minutes. A blocking solution (3% FBS in PBS) was added to wells, and rocked for 1 hour at room temperature. The primary antibody, a rabbit anti-vaccinia antibody (YVS8101; Accurate Chemicals, Westbury, New York) diluted to 1:500 in blocking solution was added, and plates were rocked for additional 1 hour at room temperature. Cells wereHealth Department J (IHD-J) strain, or recombinant WR-luc and IHDJ-luc, was performed by intranasal inoculation as previously described \[[@B31]\]. Mice were weighed and anesthetized with a solution of 1x Avertin. The appropriate challenge dose of 25- or 100-times the 50% lethal dose (25 or 100 LD~50~) of the challenge virus was suspended in endotoxin-free PBS, and 10 µl was applied into each nostril (the LD~50~s of the challenge viruses were 0.4 x 10^4^ pfu, 4.2 x 10^4^ pfu, 4.2 x 10^4^ pfu, and 3.2 x 10^4^ pfu for WR, WR-luc, IHD-J, and IHDJ-luc, respectively). Mice were observed and weighed daily for 10 to 12 days, and those that lost 25% of their original body weight were euthanized in accordance with the animal study protocol. In experiments where mice


at 37 ^°^C for 1.5 hours, virus/antibody mixtures were used to infect confluent monolayers of BSC-40 cells. Cells were infected with 100 µl per well in replicate per each serum dilution, and also with the virus control. Control wells received only DMEM medium. Assay plates were incubated for 24 hours, then fixed/stained with crystal violet as described above. The number of plaques in each well was counted, and the percent EV neutralization for each test sample was calculated using the mean plaque count in the virus control as the denominator.

Statistical Analysis {#s2.9}
--------------------

For analysis of antibody titers in the various treatment groups of mouse immunization experiments, significant differences were analyzed using either an unpaired, two-tailed Student's t test or a one-way analysis of variance (ANOVA). Fisher's exact test washamster (BHK-21) cell lines (data not shown). A34Rko and A56Rko replicated to lower titers than Dryvax in BSC-40 cells (data not shown) and the A33R/B5Rko double knockout virus replicated even more poorly than the single EV knockout viruses ([Figure 1B)](#pone-0067984-g001){ref-type="fig"}. Thus, while the deletion of *A33R* or *B5R* resulted in reduction in virus replication, the deletion of both *A33R* and *B5R* genes results in an even more dramatic decrease in total virus yield in cell culture.

In all of our vaccination studies, vaccine viruses are delivered by tail scarification to closely mimic the way in which smallpox vaccines are actually administered. Despite the reduction in virus progeny in cell culture, a robust antibody response to the EV knockout viruses was elicited following vaccination with 10^5^ pfu of virus. Analysis


cholesterol levels has been shown to be substantially correlated with a substantial reduction in the incidence of coronary events; Cohen et al, supra. This was found to be the case even in populations with a high prevalence of non-lipid-related cardiovascular risk factors; supra.
Accordingly, it is of great importance to indentify therapeutic agent permiting the control of LDL cholesterol levels.
Accordingly, it would be of great importance to produce a medicament that inhibits or antagonizes the activity of PCSK9 and the corresponding role PCSK9 plays in various therapeutic conditions.
Expression or upregulation of PCSK9 is associated with increased plasma levels of LDL cholesterol, and inhibition or the lack of expression of PCSK9 is associated with low LDL cholesterol plasma levels. Significantly, lower levels of LDL cholesterol associated with sequence variations in880 F.2d 415
Unpublished DispositionNOTICE: Sixth Circuit Rule 24(c) states that citation of unpublished dispositions is disfavored except for establishing res judicata, estoppel, or the law of the case and requires service of copies of cited unpublished dispositions of the Sixth Circuit.UNITED STATES of America, Plaintiff-Appellee,vDavid COOPER, Defendant-Appellant.
No. 88-1078.
United States Court of Appeals, Sixth Circuit.
July 28, 1989.

Before KEITH and KENNEDY, Circuit Judges and RICHARD B. McQUADE, Jr., District Judge.*
PER CURIAM.

1
Defendant David Cooper appeals his jury conviction for (1) violation of the Racketeer Influenced and Corrupt Organizations Act (RICO), 18 U.S.C. Sec. 1962(c);  (2) conspiracy to violate RICO, 18 U.S.C. Sec. 1962(d);  (3) conspiracy to distribute prescription-drug controlled substances in violation of 21 U.S.C. Secs. 846 & 841(a)(1);  (4) conspiracy to commit mail fraud in violation of


of his employees, would place a "double slash" mark on the prescription to indicate that a generic had been dispensed, but a brand name billed.  Two of these employees, Shirley Bogoff and Grayce Alfonsi, were hired to replace experienced pharmacy technicians when Unarex purchased Karp Pharmacy.  They testified that Cooper personally taught them the "double slash" mark system.  A third employee with 12 years of experience as a pharmacy technician, Deborah Garver, testified that she did not engage in generic substitution, but that specific billings, including those in Cooper's handwriting, involved such substitution.  Insurance companies, including Blue Cross/Blue Shield of Michigan, would pay Karp Pharmacy for the more expensive drug, sending payment through the United States mail to Unarex headquarters.

6
The second scheme involved theevaporated and the residue partitioned between H~2~O and CHCl~3~. The aqueous layer was washed with CHCl~3~ and evaporated to dryness. The residue was purified by semipreparative reversed-phase HPLC eluted at 5 mL/min with acetonitrile/0.1 M TEAB (1:0 → 13:7 v/v) over 25 min. Fractions were analyzed by analytical RP-HPLC eluted at 1 mL/min with ion-pair buffer: 0.17% (m/v) cetrimide and 45% (v/v) phosphate buffer (pH 6.4) in MeOH. Appropriate fractions were collected and evaporated under vacuum to give the title compound (5.3 mg, 35% over two steps): UV (H~2~O, pH 7), λ~max~ 255 nm (ε 11,100); ^1^H NMR (500 MHz, D~2~O) δ 8.88 (s, 1H, H-2), 6.06 (d, 1H, *J* = 6.1, H-1′), 6.01 (s, 1H, H-1′′), 5.31 (dd, 1H, *J* = 6.1, 2.4, H-2′), 4.62 (d, 1H,


face bloodied, eventually departed the game and did not return.

After the game, CSNNE.com reported that Green suffered a bruised left cheek and multiple chipped teeth but would be listed as day-to-day. The site further reported that Ilyasova apologized to Green for the unintentional blow.

Boston, now 14-13, will play next on Christmas against the Nets at Brooklyn's Barclays Center.

Green finished with 14 points, three rebounds, two assists, four steals and two blocks in 28 minutes for the Celtics on Friday. Forward Paul Pierce scored a team-high 35 points and registered a team-high 12 rebounds. The Bucks were led by 27 points from guard Monta Ellis. Center Larry Sanders added 17 points, 20 rebounds, three assists, two steals and one block in 39 minutes.

Green, 26, is averaging 9.4 points andpossible due to the dynamic way the Objective-C runtime works. The runtime needs these pieces of information to instantiate the class and send messages to it, so there really is no way to hide this information without breaking your library.

A:

From Apple's Documentaion, some more details: C++ Runtime Environment Programming Guide
Symbol Visibility and Objective-C
Objective-C is a strict superset of C, and Objective-C++ is a strict superset of C++. This means that all of the discussion regarding symbol visibility in C and C++ applies to Objective-C and Objective-C++ too. You can use the compiler flags, visibility attributes, and the visibility pragma to hide C and C++ code in your Objective-C code files.
In a 32-bit OS X project, these visibility controls apply only to the C or C++ subset of your


The U.S. intelligence community developed substantial evidence that state websites or voter registration systems in seven states were compromised by Russian-backed covert operatives prior to the 2016 election — but never told the states involved, according to multiple U.S. officials.

Top-secret intelligence requested by President Barack Obama in his last weeks in office identified seven states where analysts — synthesizing months of work — had reason to believe Russian operatives had compromised state websites or databases.

Three senior intelligence officials told NBC News that the intelligence community believed the states as of January 2017 were Alaska, Arizona, California, Florida, Illinois, Texas and Wisconsin.

The officials say systems in the seven states were compromised in a variety of ways, with some breaches more serious than others, from entry into state websites toat the end of the Obama administration, told NBC News that the government's assessment when he left the White House in January 2017 was that networks in seven states were compromised. He said he could not account for whether that assessment had changed in the past year.

Daniel, who is now president of the Cyber Threat Alliance, an industry group, said it was the intention of the Obama administration to inform those states, "but clearly it didn't happen the way that we wanted it to."

He said he could not name the states because some of the assessment was based on classified information.

"This continued debate about whether or not the states were notified is actually distracting from the larger point, which is that we need to build the relationship between


BRICS countries near development bank deal to rival IMF, WB — RT Business

The emerging economies of Brazil, Russia, India, China and South Africa, are a couple of days from agreeing the $10 billion BRICS development bank, as well as a $100 billion currency pool. It could challenge global lenders like the IMF and World Bank.

The bank will be called the New Development Bank, and will provide finance for infrastructure projects. Its creation will meet the needs of emerging and poorer economies according to Russian Finance Minister Anton Siluanov.

In a speech Wednesday he confirmed the funding would be divided equally, Russia will contribute $2 billion in initial capital for the BRICS bank over seven years.

The bank will start with $10 billion in cash and $40 billion in guarantees. Themy cue from Sarewitz’ article.

The first post poses the question: Can the market save us from curiosity?
That post will look into the classic collaborative projects (Research and Innovation actions in H2020) of the EU Framework Programme and possibly also get back to some the issue that I have discussed in previous posts here and here.

The next article asks the question: Is selfless honesty only a thing for scientists?That post will look at the different stakeholder groups way of engaging with and trying to steer research. And I might include a detour to how 17th century scientists in the age of Robert Boyle and John Locke handled that issue.

The fourth and final article will raise the question: Can the EU Framework Programmebe strategic?


equiaxed γ phase, little β phase and many residual lamellae. These phases are further confirmed in the following section. The residual lamellae are mainly due to the inhomogeneous deformation of the lamellar microstructure, as discussed in [Section 3.3](#sec3dot3-materials-12-01203){ref-type="sec"}. The lamellae tend to decompose completely in the region where plastic deformation occurs more easily.

Previous studies have made great progress in understanding the microstructural evolution of TiAl alloys during hot working. However, the deformation mechanism is not yet clear. Further TEM investigation was conducted on the microstructure of TiAl alloys with different deformations to study the deformation mechanism. As shown in [Figure 6](#materials-12-01203-f006){ref-type="fig"}, bending and coarsening occurred in γ/α~2~ lamellae in the deformed microstructure (20% reduction). Compared to the initial microstructure, the uniformity of the lamellar width significantly decreased. Thethe atmosphere in the vessel as the temperature of the deposition source is increased to the point where the deposition materials vaporize.
Typically, the deposition source is made from an electrically resistive material whose temperature will increase when an electrical current is passed through the container walls. The deposition material inside is then heated by radiation from the walls and by conduction from contact with the walls. Typically, the container is shaped like a box, with an aperture to allow escape (efflux) of the vapor in the direction of the substrate. However, other methods of heating the walls have been used, including radiation from coils surrounding the container, induction heating of the container with suitable coils, electron impact, and irradiation from an optical source.
If the container or housing is


QSO party). My first HF contact (outside of Field Day) was with AA4NC in North Carolina, but I was so green, I forgot to get his name during the QSO (and I’m not sure if I gave him mine). My next, and first complete exchange (well QSO party exchange) on HF was with Mel, KJ9C in Montana. Thanks guys (and everyone else, too) for your patience!

Just as I was getting going, Josh, KE0CPH called me on the phone, and a short time later, he stopped by to work some HF, alfresco. Josh couldn’t stay too long, but I enjoyed sharing my rig so he could work some HF too.

The QSO party didn’t last nearly long enough… but it was enough to let me know that my antenna wasdeeply narcissistic person. That’s why I found it so interesting to talk to Behary after Trump won, and that’s why I decided to email her to get her thoughts on what she’s seeing so far from Trump’s time in the Oval Office.

It’s worth noting, as always, that we don’t know Trump has narcissistic personality disorder — the only way to know for sure would be for him to be diagnosed by a clinician, and the odds of that happening are about equal to the odds that Trump will, as he promised in his inaugural address, wipe “radical Islamic terrorism” from the face of the earth. But in this case, NPD might simply be the best theory available to explain his propensity to behave so oddly, so consistently. In


Learning Benefits

Read lots of books about bugs and insects, and go on an insect hunt. Tell your child that scientists who study insects are called entomologists and that he is going to be one for the day. Talk about the fact that most insects have three body parts (head, abdomen, and thorax) and that most have six legs. On your hunt, use a magnifying glass to narrow your child's field of vision so he can see the individual body parts.

Developmental Note:

Some children are afraid of bugs. Be respectful and let them observe with you or a friend. Children of this age may become so absorbed in the activity that they make more legs or body parts than needed. This is totally acceptable. Talk with your child about thefrom lentivirus sample.Table 2SampleDilutionsCt valueCopy numberStd-110^11^5.13200000000000.00000Std-110^11^5.49200000000000.00000Std-210^10^8.9420000000000.00000Std-210^10^8.5220000000000.00000Std-310^9^12.352000000000.00000Std-310^9^12.562000000000.00000Std-410^8^16.37200000000.00000Std-410^8^16.14200000000.00000Std-510^7^20.3120000000.00000Std-510^7^20.5520000000.00000Std-610^6^24.082000000.00000Std-610^6^24.122000000.00000Std-710^5^27.83200000.00000Std-710^5^27.33200000.00000Std-810^4^29.6620000.00000Std-810^4^29.5620000.00000Sample-110^−1^24.121326041.51081Sample-110^−1^24.281198896.77120Sample-210^−2^28.02110807.70660Sample-210^−2^28.01111306.77372Sample-310^−3^31.7710097.38460Sample-310^−3^31.5111931.16565Sample-410^−4^NDSample-410^−4^NDSample-510^−5^NDSample-510^−5^ND[^1]Fig. 1293T cells cultured in the medium containing various concentrations of puromycin in order to determine the minimum concentration of the drug that could completely killed all cells within 3--5 days. (A) 293T cells without puromycin. (B--J) 293T cells treated with puromycin at 0.5, 1, 3, 5, 8, 10, 25, 50, and 100 μg/ml, respectively. All 293T cells cultured in the selecting medium containing 3 μg/ml puromycin died at day 4 post antibiotic treatment (D) whereas the cells treated with the higher concentration of puromycin died within 2 days (E--J).Fig. 1Fig. 2Reactivity between GΔTM protein from culture medium supernatant and anti-histidine tag monoclonal antibody as examined by Western blot analysis. Lanes 1--17 indicate GΔTM protein secreted from 293T_GΔTM stable cell clone no.1--17, respectively.Fig. 2

2. Experimental design, materials


Preclinical evaluation of 90Y-labeled anti-CD20 monoclonal antibody for treatment of non-Hodgkin's lymphoma.
A high-affinity IgG1 kappa murine monoclonal anti-CD20 antibody (IDEC-2B8) was developed for radioimmunotherapy of non-Hodgkin's B-cell lymphoma. A stable immunoconjugate (Zevalintrade mark) was prepared by reacting IDEC-2B8 with a derivative of diethylenetriaminepentaacetic acid, designated MX-DTPA, a chelator exhibiting high affinity and retention for 90Y. Zevalin exhibited antigen specificity, human tissue reactivity, and preclinical safety profile comparable to the native antibody. The conjugate radiolabeled with 90Y (90Y-Zevalin) or 111In (111In-Zevalin) exhibited excellent retention of immunoreactivity with radioincorporations >95%. The radiolabeled conjugates formulated in PBS containing human serum albumin were stable in vitro at 4 degrees C for 48 h as indicated by negligible loss of radioisotope and retention of binding to CD20+ cells. In vitro human serum stabilitystudies at 37 degrees C with 90Y-Zevalin indicated that loss of 90Y from the conjugate was minimal, averaging 1% per day. Biodistribution studies in BALB/c mice confirmed the in vitro stability of 90Y-Zevalin and 111In-Zevalin. In particular, excellent in vivo retention of 90Y by the conjugate was demonstrated by minimal bone accumulation (</=3% of the injected dose over three days). Radiation dose estimates to normal organs calculated from mouse biodistribution studies with 90Y-Zevalin were comparable to those determined in a phase I/II clinical trial and below generally accepted safe radiation levels. Studies in athymic mice bearing CD20+ tumors demonstrated that 111In-Zevalin accumulated in the tumors preferentially compared with normal organs. 90Y-Zevalin is currently being evaluated in phase III clinical trials for treatment of relapsed or refractory low-grade, follicular


and the shoulder buttons, have a wonderfully tactile feel. They press quickly but feel well-built and give a steady grip. The two optical trackpads, however, we're not so sure about. From what we could try of them, the precision seemed fairly coarse. In FIFA, for example, it tended to result in all-or-nothing movement rather than fine-grained steps. We'd need to try games where precision is more important to confirm this.

The games themselves behave much as you'd expect for modern mobile 3D games more than they do PlayStation titles, but that's not a bad thing. The physical controls definitely help for action titles by taking your hands off the screen so you can focus on the full field of play. We had the most fun with Bruce Lee, sinceRev. D 57, 2996 (1998).

A. Ali, G. Kramer and C. D. Lu, Phys. Rev. D 58, 094009 (1998).

Y. H. Chen, H. Y. Cheng, B. Tseng, K. C. Yang, Phys. Rev. D 60, 094014 (1999).

M. Beneke, G. Buchalla, M. Neubert, C. T. Sachrajda, Phys. Rev. Lett. 83, 1914 (1999).

M. Beneke, G. Buchalla, M. Neubert, C. T. Sachrajda, Nucl. Phys. B 591, 313 (2000).

M. Beneke, G. Buchalla, M. Neubert, C. T. Sachrajda, Nucl. Phys. B 606, 245 (2001).

T. Muta, A. Sugamoto, M. Z. Yang and Y. D. Yang, Phys. Rev. D 62, 094020 (2000).

D. s. Du, D. s. Yang, G. h. Zhu, Phys. Lett. B 488, 46 (2000).

D. s. Du, H. u. Gong, J. f. Sun, D. s. Yang, G. h. Zhu, Phys. Rev. D 65, 074001 (2002).

M. Z. Yang,


                    $(1.79\pm0.16)~\%$
   0.35cm $B_s^{0}\rightarrow{D^*_s}^{\pm}{K^{*}(890)}^{\mp}$   $(1.63\pm0.86)\times10^{-4}$   $3.47^{+1.96+1.07+0.11}_{-1.35-1.66-0.11}\times10^{-4}$              $  - $
     0.35cm $B_s^{0}\rightarrow{D^*_s}^{\pm}{D^{*}}^{\mp}$      $(6.76\pm2.69)\times10^{-4}$                             $-$                                       frequency as a function of proportional and integral controls can be expressed as in relations (1) and (2). The output frequency FVCO of the RXVCO is a function of integral control word DI with KVCOI gain and proportional control word DP with KVCOP gain. Proportional control has a character of pulse width modulation, and integral control is simply level based. FIG. 2 shows a portion of the CDR of FIG. 1 incorporating a counter-based lock to reference mode of operation of the prior art.
As shown in FIG. 2, counter-based lock to reference 200 comprises frequency divider 201, counter1 202, counter2 203, FSM (finite state machine) 204, and MUX 205, which are employed in combination with RXVCO 110 and limiting integrator 116 when loss of serial data to the


matching 345: like substrings but still allow 23 VAL: like ones, use
\b(?=[0-9. ]*[A-Z])[A-Z0-9][A-Z0-9. ]*:

See this regex demo. Here, \b(?=[0-9. ]*[A-Z]) matches a word boundary first, and then the positive lookahead (?=[0-9. ]*[A-Z]) makes sure there is an uppercase letter after 0+ digits, spaces or dots.
If you do not expect numbers at the start of the sequence, i.e. out of I have a 22 C. GRAY CAT2:, you need to extract C. GRAY CAT2, use Sebastian's suggestion (demo).

addressing transaction status in the Golem UI. As per usual, we recommend you to upgrade. https://medium.com/@golemproject/brass-golem-beta-0-16-2-cdab0bcd554a 2 years ago

Gearing up for a weekend full of great community discussions, thanks @EthMagicians for the invite! https://twitter.com/ethmagicians/status/1017025066314412032 2 years ago

Solid deep dive into models similar to UBI, enabling true ownership of game content AND blockchain by… https://twitter.com/i/web/status/1016790547892260864 2 years ago

Remember the epic photo we shared yesterday? WE GOT THE VID! @julianzawist presents "The End of Trust" at… https://twitter.com/i/web/status/1016710596782370817 2 years ago

Our CEO @julianzawist will join a panel with @koeppelmann and others on the day 2 of @dappcon_berlin, looking forwa… https://twitter.com/i/web/status/1016700582818611200 2 years ago

1 week left to apply as Community Manager! Heads up! We are looking for a community manager to be based in Warsaw.… https://twitter.com/i/web/status/1016665595092365312 2 years ago

We really enjoyed the


evolution of such and more with @makerdao, @melonport, @cryptokitties,… https://twitter.com/i/web/status/1015591511365505025 2 years ago

Crypto exchanges: decentralized and centralized with @coinbase @VitalikButerin @mi_ayako @vchatBKK @omise_go https://t.co/hBZgLGW9vP 2 years ago

Next up’s @VladZamfir - on Governance, of course: if blockchain governance doesnt interfere with the execution of p… https://twitter.com/i/web/status/1015566234627211264 2 years ago

Kicking off the #Ethereummeetup2018 @VitalikButerin explains transactions from the ground up https://t.co/d6pEKykU7N 2 years ago

Thanks for having us @web3foundation! Looking forward to tomorrow's @TechCrunch Ethereum meetup! https://twitter.com/eathomson/status/1015334472189915136 2 years ago

We're checking out today's #TCBlockchainSessions and will see you tomorrow at the @TechCrunch @ethereum meetup, whe… https://twitter.com/i/web/status/1015177194853806080 2 years ago

Hackers are already making their travel plans to Berlin to #BUIDL applications and get the best mentors and educati… https://twitter.com/i/web/status/1014854805817315328 2 years ago

Also, don't miss out on @dappcon_berlin where Aleksandra takes the stageago

Happy to attend and listen what these great @ethereum community folks have to say - we're all in this together :) https://twitter.com/lrettig/status/1011008412531023872 2 years ago

We are checking the questions of our upcoming AMA and honestly, we expect much more from the community. We want you… https://twitter.com/i/web/status/1010821382039654401 2 years ago

Great insights on @joincolony dev incentives for their hackathon. Worth a read (or two) :) https://twitter.com/joincolony/status/1006909486714540032 2 years ago

As we prepare ourselves for next week @reddit AMA we would like to let you know that our Bug Bounty Competition has… https://twitter.com/i/web/status/1010091065720954881 2 years ago

We’re at @fullnode_berlin our Berlin office at one of the first meetups at the space. @chriswaclawek is chatting wi… https://twitter.com/i/web/status/1009862472310902785 2 years ago

Our COO @andrzejregulski presented today at #BlockchainNext in Warsaw https://twitter.com/anna_pietruszka/status/1009806907199119362 2 years ago

We're multi-tasking at


two teams together, check out Golem’s blog post: https://blog.golemproject.net/reaching-out-52ea8db1ce12 We apol… https://twitter.com/i/web/status/973926190183518209 2 years ago

Hello new patch release! Alpha2 0.13.0 has landed. Please check it out and download --> https://blog.golemproject.net/brass-golem-alpha2-0-13-0-10f502a558ee 2 years ago

Looking forward to #EthereumJapan meetup with @omise_go, @karl_dot_tech, @davidlknott and a very special host ;) https://ethereumjapan.org/ 2 years ago

Check the amazing job that these peeps did. 50 Ethereum devs interviewed so they could learn about what their needs… https://twitter.com/i/web/status/973569786851594245 2 years ago

All the best to our friend and collaborator Marek on this adventure. We fully support this initiative! https://twitter.com/marekosiecimski/status/973516248955932672 2 years ago

We were lucky enough to catch @WhitfieldDiffie for some minutes and ask him some questions. Look how thrilled Lukas… https://twitter.com/i/web/status/973197771183480832 2 years ago

We were lucky enough to catch @WhitfieldDiffie for some minutes and ask himTwitter/Led By Donkeys Brexit billboards: Campaigners remind MPs of past promises Theresa May triggered Article 50 on 29 March 2017. Her withdrawal deal is yet to be passed. Twitter/Led By Donkeys Brexit billboards: Campaigners remind MPs of past promises A classic from the 2015 general election campaign. David Cameron resigned on 24 June 2016, following the EU referendum result. Twitter/Led By Donkeys Brexit billboards: Campaigners remind MPs of past promises David Davis resigned from his post as Brexit secretary in July 2018 after disagreeing with Theresa May's negotiation strategy. Twitter/Led By Donkeys Brexit billboards: Campaigners remind MPs of past promises Michael Gove was one of the most influential Leave voices during the EU referendum campaign. Twitter/Led By Donkeys Brexit billboards: Campaigners remind MPs of past promises Jacob Rees-Mogg,


we get in touch by email, by post, by phone or by texting you, depending on the contact information you share with us. There could be a number of reasons for this, for example, we may need to respond to and handle requests you have made.

Market research: We may ask our customers to take part in market research. Any additional personal details that you give us as part of the market research will only be used with your consent.

Fraud detection and prevention: We may use personal information for the detection and prevention of fraud and other illegal or unwanted activities.

Improving our services: Finally, we use personal information for analytical purposes, to improve our services, enhance the user experience, and improve the functionality and quality of our services.

When youlike this one, it often ends in you losing your money and your "account executive" keeping his bonuses.

So, my advice to you: #1 Educate yourself.

Why? So that you can invest by yourself, not through funds, and so have better control over the risks.

2.- Accept that every investment carries risks, and that the higher the promised return, the higher the risk. This is specially true for scams. If someone promises you a return that is way above market average (1% a month, for instance), then he is probably going to keep your money and run. That doesn't mean all risky investments are scams. Look at third world countries. Their risk derives from the difficulty to move money into and out of the country, or due to corrupt politicians. Doesn't


buying my occassional starbucks and such. Thus I gave myself a misc. allowance each month for this purpose and never go over it. That way I have no surprises and have a much easier time denying myself stupid little cravings.

The soda as water thing isn't even an exaggeration. I know one guy who he and his wife has three boxes of diet coke in their garage at any given moment and they "never felt a need to drink water." They recently felt adventurous and bought a box with lime flavoring. I shudder.

I am the daughter of a physicist turned successful investor, who lives on his investment income and paid for my college education and more, and I had little finance education until recently. (I'm 28.) I started investingand sell as it goes down.

Buy companies you understand and have a good feel for. Annual reports are bullshit, analyst are liers, there is a lot of disinformation out there.

Once you make a significant investment in one cmopany, I would recommend looking for a different company. Again, buy shit you understand and you think will do well long term. Don't worry about daily, monthly or yearly fluctuations.


included in the NHIS-NSC, 387,683, who received screening within the period from January 1, 2012 to December 31, 2013, were selected. A total of 8025 patients who were newly diagnosed with diabetes mellitus (DM), were selected for the study, except for those who were under 20 years of age and those who were prescribed statin only once. In these patients, we observed a record of statin prescriptions for 3 years prior to diagnosis of NODM. Therefore, the study period was defined as 2009--2013, and the wash-out period was 3 years before the study period (2006--2009). We restricted statin users to new statin-users by excluding patients with statin use records for the wash-out period. Patients were also excluded from the study if they were diagnosed with T2DM or they had a historyBackground
==========

Alzheimer's disease (AD) is the most common cause of dementia among the elderly. With the advent of the aging society, 24.3 million people are estimated to suffer dementia worldwide, increasing to 42.3 million people by 2020 and 81.1 million by 2040 \[[@B1],[@B2]\]. The total estimated worldwide costs of dementia are US\$604 billion in 2010, and are estimated to increase by 85% to 2030 \[[@B3]\]. The cost for caring for the increasing number of people with dementia will rise dramatically and thus will be disastrous burden to our societies within upcoming 10--20 years. To address this social issue, clarification of the pathogenic mechanism of AD and development of AD drugs are urgently expected.

Genetic association with putative AD susceptibility genes has been studied and collected as a publicly available database called


would toss my jacket after school, for which my mother would scold me: Hang it up! The bitter taste of cardamom, too, those seemingly inescapable pods that I detested yet never managed to avoid, biting into them by accident at dinner. My friends didn’t know what a divan was or why we didn’t call it a couch. And cardamom, well, cardamom was a flavor they’d never encountered.

These accumulations from life growing up in our house, passed down not merely through memory’s piping but in actions, are re-experienced most in the summer. Despite New York City’s stifling weather, how the air warps itself into a muggy mass, I drink hot tea and eat hot soup. It cools me down. Because in that sly way science naturally alloys with whatto themselves, and some people like to use their public key. It's
> really a matter of taste. I prefer to use my public key so I don't
> have one more passphrase to remember ;)
> David
> _______________________________________________
> Gnupg-users mailing list
> Gnupg-users@gnupg.org
> http://lists.gnupg.org/mailman/listinfo/gnupg-users
yours,
haruki
----119$&89#jFS-=)(3~`
www.votenader.org
-@$____CARRIER_LOST.------
From amilivojevic at pbl.ca Fri Oct 1 16:40:31 2004
From: amilivojevic at pbl.ca (Aleksandar Milivojevic)
Date: Fri Oct 1 16:33:47 2004
Subject: Is it possible to encrypt file symmetrically with 1
(one) command line?
In-Reply-To: <20040930221223.GR20251@dionysus.chud.net>
References: <415C79CD.6000702@bluewin.ch>
<20040930221223.GR20251@dionysus.chud.net>
Message-ID: <415D6C5F.90902@pbl.ca>
Chris De Young wrote:
> On Thu, Sep 30, 2004 at 11:25:33PM +0200, Oleksiy Muzalyev wrote:
>
>>I call from VB2005:
>>
>>Shell("c:\gnupg\gpg.exe -a -c " & fileToEncrypt, AppWinStyle.NormalFocus)
>>
>>And console window opens and asks twice for the password.
>>
>>I would prefer to send the file path and password in one command.
>
>
> Offhand I don't know of any switches that you can use


to pass the
> passphrase on the command line, though I might be missing one. If
> it's acceptable to store the passphrase in a separate file (probably
> no more risky that coding it into a script), you could use:
>
> gpg -a -c --batch --passphrase-fd n filename
>
> which will read the password from file descriptor n. 0 means standard
> input, though that's not what you want in the case.
Hm, why not using 0? I don't know how VB handles redirection of
stdin/stdout between processes, however this works quite well in Perl on
Unix:
#! /usr/bin/perl
$gpg_exe = "gpg";
@gpg_args = ($gpg_exe, "--quiet", "--batch", "--no-tty",
"--passphrase-fd", "0", "-a", "-c", "blah");
open(FH, "|-") || exec @gpg_args or die "Can't execute GnuPG!";
print FH "passpharase\n";
close(FH) or die "Encryption failed!";
What this does is that it starts new gpg process, and ties itsyou should split hash number one into two parts
/Thomas
--
== Encrypted e-mails preferred | GPG KeyID: 114AA85C
--
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From ajaja at mail.ru Sun Oct 3 20:46:24 2004
From: ajaja at mail.ru (Alex Moroz)
Date: Sun Oct 3 20:43:24 2004
Subject: [Announce] GnuPG 1.3.90 released (development)
In-Reply-To: <899506412.20041003195722@mail.ru>
References: <20041002134723.GB15332@jabberwocky.com>
<899506412.20041003195722@mail.ru>
Message-ID: <1179620959.20041003214624@mail.ru>
Hello!
M> I have a strange problem in my Mingw32 (GCC 3.4.2) build of GnuPG
AM> v1.3.90. An 'updpref' command not function. The programm crashes.
AM> GnuPG v1.3.6 build was OK.
I commented line 1750 in g10/keyedit.c:
//show_prefs(temp,NULL,1))
and crash disappeared.
Why NULL? There is access to variable 'selfsig' (second param in
show_prefs) in this function (line 1974 of keyedit.c):
pref_ks=parse_sig_subpkt(selfsig->hashed, SIGSUBPKT_PREF_KS,&pref_ks_len);
^^^^^^^^^^^^^^^^
--
Best regards,
Alex. mailto:ajaja@mail.ru
From jharris at widomaker.com Mon Oct 4 01:51:25 2004
From: jharris at widomaker.com (Jason Harris)
Date: Mon Oct 4


that it's running
> setuid root and drop privileges).
Another poster also talked about getting rid of windows. However I do need to
run windows from time to time. Also I do not have root access on my linux
machine (it is used at work). So does that mean that gpg is not for me? Or is
there anything available which could erase the swap space anytime I want? I
just looked around in the M$ knowledgebase and it has a workaround to clear the
pagefile at shutdown. Is that a useful compromise?
>
> --
> Shawn K. Quinn
>
-------------------------------------------------
This mail sent through Virus Free Email
http://www.vfemail.net
From twoaday at freakmail.de Mon Oct 4 19:37:30 2004
From: twoaday at freakmail.de (Timo Schulz)
Date: Mon Oct 4 19:38:46 2004
Subject: Special characters in passphrase not being recognized
In-Reply-To:
References:
Message-ID: <20041004173730.GA16785@daredevil.joesixpack.net>
On Mon Oct 04 2004; 06:30, An?balRojas wrote:
> 1.2.1. With "Windows Privacy Tools" I managed to create a key where
> the passprhase contains special characters (accented characters and so
> on), when I do my tests using WPT everything works ok, but when I use
In earlier versions of WinPT the UTF-8 support was broken. It is still
not complete but WinPT 0.9.12 has a workaround for this.
Timo
--
Colt at WinPT.org keyid BF3DF9B4 (http://www.winpt.org)
WinPT (http://www.stud.uni-hannover.de/~twoaday/winpt.html)
From malte.gell at gmx.de Mon Oct 4 19:49:13 2004
From: malte.gell at gmx.de (Malte Gell)
Date: Mon Oct 4 19:46:22 2004
Subject: Implications of using insecure memory
In-Reply-To: <1096858592.02c913acc4ea0@www.vfemail.net>
References: <1096759756.b90348978578b@www.vfemail.net>
<20041002230902.T23687@willy_wonka>
<1096858592.02c913acc4ea0@www.vfemail.net>
Message-ID: <200410041949.13589.malte.gell@gmx.de>
On Monday 04 October 2004 04:56, shatadal@vfemail.net wrote:
> Quoting Atom 'Smasher' :
[...]
> > i dunno about windoze, but on *nix you can solve this by setuid-ing
> > the gpg binary... that would force it to only use secure


between signing and clearsigning is that with
> clearsigning, the original text is preserved and fully readable
> even without a public key of the author and with
> signing, it gets compressed and safed in binary form.
It may or may not be comperssed depending on the other options.
> When I encrypt a text, it gets compressed anyway.
By default yes.
> Why does it make a difference, whether I use signing or
> clearsigning on a compressed text?
The preferred method is to use PGP/MIME (rfc3156) and not
clearsigning. If you sign files you should in general use a detached
signature so that the file may be sued without processing it through
gpg.
If you file is plain ASCII --clearsign may be used to avoid the
overhead of PGP/MIME and to make verification easier. If you use a
different character(Nico Schottelius)
Date: Fri Oct 15 15:07:35 2004
Subject: Extracting information from a key
In-Reply-To: <871xg19fyz.fsf@wheatstone.g10code.de>
References: <20041014140922.GF14931@schottelius.org>
<871xg19fyz.fsf@wheatstone.g10code.de>
Message-ID: <20041015131103.GH695@schottelius.org>
Werner Koch [Thu, Oct 14, 2004 at 10:56:04PM +0200]:
> On Thu, 14 Oct 2004 16:09:22 +0200, Nico Schottelius said:
>
> > - display the ID of it (readable by other programs)
> > - display E-Mail, Name
> > - display signatures on the key
> > - display other information (key type, length)
>
> Some ietms are displayed with -i
Sounds good, but is there any promise the output won't change?
Using
scice% cat my-pgp-key | gpg -i
pub 1024D/8D0E27A4 2003-01-12 Nico Schottelius (the penguin gets you)
uid Nico Schottelius (the penguin gets you)
uid Nico Schottelius (business)
uid Nico Schottelius (the penguin gets you)
sub 4096g/3976EA51 2003-01-12 [expires: 2007-01-11]
sub 4096R/C251BAE5 2004-05-08 [expires: 2007-05-08]
works fine, but when trying with --status-fd option (which I use
for communication between


by somebody who
did it install a prior version but then the procedure is a little
uncomfortable (but not impossible!).
And of course it would be possible to use an installer with the
G-DATA plugin and then simply override the files. Then the step
with the manual registry modifications can be avoided.
> Will g10 Code GmbH release a version with an installer?
At the moment, I cannot answer this question.
Timo
From zwon at severodvinsk.ru Wed Oct 20 22:39:55 2004
From: zwon at severodvinsk.ru (Pawel Shajdo)
Date: Wed Oct 20 22:45:32 2004
Subject: How to find the reason for a revocation
In-Reply-To: <20041018140715.GA5824@pc5.i.0x5.de>
References: <20041018140715.GA5824@pc5.i.0x5.de>
Message-ID: <20041020203955.GA829@sky.schizandra.ru>
On Mon, Oct 18, 2004 at 04:07:15PM +0200, Nicolas Rachinsky wrote:
> when I revoke a signature on an uid, gpg asks for the reason and a
> description.
>
> ----
> Please select the reason for the revocation:
> 0this communication and any attachments is strictly prohibited. If you have received this communication in error, please notify the sender by reply transmission and delete the message without copying or disclosing it.
==============================================================================
From mamta.mehra at us.ing.com Wed Oct 20 22:27:35 2004
From: mamta.mehra at us.ing.com (Mamta Mehra)
Date: Thu Oct 21 09:40:42 2004
Subject: gpg: fatal: can't open /dev/urandom
Message-ID:
We are implementing PGP on Integration Server by using OpenPGP package from
webMethods. As required by OpenPGP package, we have installed/configured
GnuPG software in our DEV environment.
Environment details:
IS running on AIX 5.2
Integration Server 6.1
OpenPGP package version 1.1
GnuPG Version 1.5.8
The solution is implemented successfully in our DEV environment.
While migrating to QA environment, we ran into following-like error when
creating the PGP keys.
gpg: fatal: can't open /dev/urandom: There is a request to a device or
address that does not exist.
Our


highly appreciated.
Thanks in advance.
Sincerely,
Servie
__________________________________
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Take Yahoo! Mail with you! Get it on your mobile phone.
http://mobile.yahoo.com/maildemo
From zuxy.meng at gmail.com Fri Oct 22 19:30:25 2004
From: zuxy.meng at gmail.com (Zuxy)
Date: Fri Oct 22 19:27:01 2004
Subject: [Announce] GnuPG 1.3.91 released (development)
In-Reply-To: <20041022170920.75005.qmail@web52501.mail.yahoo.com>
References: <20041022170920.75005.qmail@web52501.mail.yahoo.com>
Message-ID:
On Fri, 22 Oct 2004 10:09:20 -0700 (PDT), Servie Platon
wrote:
> Hi folks,
>
> My questions are these:
>
> 1. I would like to try out the development version and
> compile from source. Since, I have already a working
> copy and have compiled myself, how do I upgrade from
> version 1.2.6 to 1.3.91 so that I could try out the
> development stage?
Since you built 1.2.6 from source instead of installing an rpm
package, you can safely download the 1.3.91 source and build it as you
did for 1.2.6, I suppose it'll overwrite the oldwon't do).
--
Neil Williams
=============
http://www.codehelp.co.uk/
http://www.dclug.org.uk/
http://www.isbn.org.uk/
http://sourceforge.net/projects/isbnsearch/
http://www.biglumber.com/x/web?qs=0x8801094A28BCB3E3
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From servie_tech at yahoo.com Sun Oct 24 02:59:49 2004
From: servie_tech at yahoo.com (Servie Platon)
Date: Sun Oct 24 02:56:52 2004
Subject: Adding a Comment
Message-ID: <20041024005949.67343.qmail@web52505.mail.yahoo.com>
Hi folks,
I am sorry if this may have been asked before.
Is there a way to add a comment, after one has
generated a key? I know, this is not as important but
I am just curious if it is possible after you have
saved your keys?
Thanks.
Sincerely,
Servie
_______________________________
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Declare Yourself - Register online to vote today!
http://vote.yahoo.com
From servie_tech at yahoo.com Sun Oct 24 03:08:44 2004
From: servie_tech at yahoo.com (Servie Platon)
Date: Sun Oct 24 03:05:47 2004
Subject: [Announce] GnuPG 1.3.91 released (development)
In-Reply-To:
Message-ID: <20041024010844.81863.qmail@web52509.mail.yahoo.com>
Hi Zuky,
Thank you for the suggestion earlier.
I have extracted the the gnupg binaries


have s2k-cipher-algo AES256
> > WinPT still uses CAST5
>
> Indeed I use a default for symmetric encryption A long time ago I
> did it to fix some GPG -> PGP6 problems.
I see & understandable :)
> I will change it so it
> honors the option if it is available (or "cipher-algo").
Mmh, i think cipher-ago is not a good idea, because it is not so
flexible as the first mentioned ID in personal-cipher-preferences or
secondary the name with s2k-cipher-algo. I mean, if somebody uses GnuPG
for public key crypto without WinPT...
--
Ciao
Kai
WWW: http://kai.iks-jena.de/
Blog: http://rabenhorst.blogg.de/
GnuPG-Key: 0xD6E995A0
Jabber: kraven@jabber.ccc.de
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From pt at radvis.nu Sun Oct 24 22:31:43 2004
From: pt at radvis.nu (Per Tunedal Casual)
Date: Sun Oct 24 22:30:41 2004
Subject: Symmetric encryption and mdc
In-Reply-To:CAST5 cipher force
if I found an option in the gpg.conf which would override it.
And for WinPT this is only a problem when you use symmetric encryption.
I guess most of the time, people use public-key encryption.
Timo
--
Colt at WinPT.org keyid BF3DF9B4 (http://www.winpt.org)
WinPT (http://www.stud.uni-hannover.de/~twoaday/winpt.html)
Installer (http://www.equipmente.de/viewtopic.php?t=433#1080)
From wk at gnupg.org Mon Oct 25 20:08:40 2004
From: wk at gnupg.org (Werner Koch)
Date: Mon Oct 25 20:09:27 2004
Subject: Gnupg for Windows and key generation?
In-Reply-To: <4174DB42.5090007@siba.fi> (Severi Salminen's message of "Tue,
19 Oct 2004 12:15:46 +0300")
References: <4174DB42.5090007@siba.fi>
Message-ID: <87d5z6n00n.fsf@wheatstone.g10code.de>
On Tue, 19 Oct 2004 12:15:46 +0300, Severi Salminen said:
> 6. If all the above information is available somewhere I'd appreciate a
> link.
@Book{Gut:02:CSA,
author = "Peter Gutmann",
title = "Cryptographic Security Architecture",
language = "USenglish",
publisher = pub-SV,
address = pub-SV:adr,
pages = "xviii + 320",
year = "2002",
ISBN = "0-387-95387-6",
keywords = "cryptograpy",
}
which contains an update of the


400) and sodium lauryl sulphate were received from Merck Ltd., Mumbai (India). The polymers were dissolved in solvent mixture of distilled water and alcohol.

2.2. Methods {#sec2.2}
------------

### 2.2.1. Preformulation Studies {#sec2.2.1}

*Solubility Studies*. Solubility may be defined as spontaneous interaction of two or more substances to form homogeneous dispersions. The solubility of buspirone hydrochloride was studied in various aqueous and nonaqueous solvents. 10 mg of drug was taken in 10 mL of each solvent at room temperature, in screw-capped test tubes and shaken for 24 h in wrist action shaker. The solubility was checked by UV spectroscopy at 254 nm \[[@B5]\].

*Partition Coefficient.*The partition coefficient directly influences the permeability through various membranes. The study has been designed to determine partition coefficient of drug in 1-octanol: phosphate buffer saline (PBS) pH 6.8 \[[@B6]\].

*Partition Coefficient between 1cheering for Richard Dawkins and Tim Minchin, however, I also realized how important it is that humanism, and not just atheism, be part of this revolution. Indeed, for humanists, the success of the secular movement is only half the battle. After all, humanism is not just an arm of secularism, but a hybrid of the secular movement and the progressive movement.

If this seems difficult to understand, bear in mind that Karl Rove is reportedly an atheist, but he certainly would not find the American Humanist Association to be a comfortable fit for his worldview. Atheism, which addresses only the issue of the existence of gods, has no social, political, or economic , nor must an atheist reject all supernaturalism. An atheist might believe in astrology, , magic, and


have they considered what their more secular society will look like?

Ironically, most of these students are indeed humanists, not just atheists and agnostics. They are tolerant and peaceful, and they see racism, , militarism, homophobia, and tribalism as phenomena that belong to the past, not the future. They don't want unrestrained corporate power, nor do they want government dictating what happens in the bedroom. They are proudly secular, seeing the emergence of their lot as a step toward a more enlightened society. In the longer term, however, they must realize that the secular movement is but one campaign in a larger war.

Indeed, if today's well-meaning youth aren't careful, a successful secular movement could nevertheless result in a country that is still hostile to most humanist values. In a
385 F.Supp. 1357 (1974)
Daniel FRIEDLANDER et al., Plaintiffs,
v.
Joseph CIMINO, M.D., Individually and as Commissioner of the Department of Health of the City of New York, et al., Defendants.
No. 73 Civ. 2276.
United States District Court, S. D. New York.
December 2, 1974.
*1358 *1359 Rothblatt, Rothblatt, Seijas & Peskin, by Henry Rothblatt, New York City, for plaintiffs.
Adrian P. Burke, Corp. Counsel, New York City, for municipal defendants; David W. Fisher, Edward P. Walla, New York City, of counsel.
Louis J. Lefkowitz, Atty. Gen., of the State of New York, New York City, for state defendants; David Spiegel, Jerold Probst, Asst. Attys. Gen., of counsel.
Paul J. Curran, U. S. Atty., S. D. N. Y., for defendants Weinberger and Dept. of Health, Education and Welfare; Gregory J. Potter, Asst. U. S. Atty., of counsel.

MEMORANDUM
BONSAL,


New York, 316 F.Supp. 1246, 1250 (S.D.N.Y.1970). The defendants' permit and proficiency testing programs are essential to protect the public from the consequences of incompetent clinical laboratory testing. To achieve this goal, it is appropriate that the State and City require clinical laboratories to obtain permits based upon proficiency tests. Therefore, these programs are well within the bounds of the State's police power. See North Dakota State Board of Pharmacy v. Snyder's Drug Stores, Inc., 414 U.S. 156, 94 S.Ct. 407, 38 L.Ed.2d 379 (1973); Williamson v. Lee Optical of Oklahoma, Inc., 348 U.S. 483, 487-488, 75 S.Ct. 461, 99 L.Ed. 563 (1955); S.P.S. Consultants, Inc. v. Lefkowitz, 333 F.Supp. 1373 (S.D.N.Y.1971) (3-judge court). See Seagram & Sons, Inc. v. Hostetter, 384 U.S. 35, 47, 86 S.Ct. 1254,Electrophoretic mobility of composite objects in free solution: application to DNA separation.
We propose here a simple procedure to estimate the electrophoretic mobility of composite objects obtained by linking two charged subunits, stressing that this electrophoretic mobility is in general different from the ratio of the total charge to the total friction coefficient. We focus especially on the situation where at least one of the subunits is a polyelectrolyte. Our remarks in particular correct the existing theoretical analysis of separation capabilities of devices in which a buoy (sphere, protein, polymer) is attached to a DNA chain. We also predict that, in some cases, the direction of electrophoretic motion can be reversed by increasing the electric field amplitude.


is the amount the planet will warm when accounting for the various feedbacks affecting the global climate. The relevant formula is:

dT = λ*dF

Where 'dT' is the change in the Earth's average surface temperature, 'λ' is the climate sensitivity, usually with units in Kelvin or degrees Celsius per Watts per square meter (°C/[W m-2]), and 'dF' is the radiative forcing, which is discussed in further detail in the Advanced rebuttal to the 'CO2 effect is weak' argument.

Climate sensitivity is not specific to CO2

A common misconception is that the climate sensitivity and temperature change in response to increasing CO2 differs from the sensitivity to other radiative forcings, such as a change in solar irradiance. This, however, is not the case. The surface temperature change is proportional to the sensitivity andyears as measured from ice cores

What is the possible range of climate sensitivity?

The IPCC Fourth Assessment Report summarized climate sensitivity as "likely to be in the range 2 to 4.5°C with a best estimate of about 3°C, and is very unlikely to be less than 1.5°C. Values substantially higher than 4.5°C cannot be excluded, but agreement of models with observations is not as good for those values."

Individual studies have put climate sensitivity from a doubling of CO2 at anywhere between 0.5°C and 10°C; however, as a consequence of increasingly better data, it appears that the extreme higher and lower values are very unlikely. In fact, as climate science has developed and advanced over time , estimates have converged around 3°C. A summary of recent climate sensitivity studies can


for several sectors and different temperatures are indicated in the top part of the figure.

If we manage to stabilize CO2 levels at 450 ppmv (the atmospheric CO2 concentration as of 2010 is about 390 ppmv), according to the best estimate, we have a probability of less than 50% of meeting the 2°C target. The key impacts associated with 2°C warming can be seen at the top of Figure 5. The tight constraint on the lower limit of climate sensitivity indicates we're looking down the barrel of significant warming in future decades.

"Global warming of 2°C would leave the Earth warmer than it has been in millions of years, a disruption of climate conditions that have been stable for longer than the history of human agriculture. Given the drought thatthere is global warming, if not, global cooling. There is a large natural range encompassing both cases and a lot in the middle.

"BTW, proving that humidity has gone up on average means nothing. The distribution of water vapor is the only thing that causes or doesn't cause global warming. If water vapor is evenly distributed then there is global warming, if not, global cooling. There is a large natural range encompassing both cases and a lot in the middle."

You are in error.

1. As my earlier link clearly shows, global humidity anomalies have increased since 1970 (by about 4%, the equivalent volume of Lake Erie of the Great Lakes). As humidity levels in the air normalize within nine days (excess precipitates out while evaporation "refills the tanks"), in order


overall IR optical depth τ due to increased GHG concentration can be compensated for by making its distribution skewed. Water vapor, as a not well mixed GHG is perfect for this purpose.

I do not put expression for entropy production here, because it is a bit complicated. But you can figure it out yourself based on radiative entropy flux of a black body being 4/3·σ·T3.

Anyway, overall entropy production is also increased by decreasing τeff, so the maximum entropy production principle pushes the climate system toward an uneven GHG distribution whenever it is possible.

Note cloud albedo is not taken into account at all in this discussion, only clear sky water vapor distribution.

#40KR at 12:24 PM on 11 September, 2010As I stated in this post, small scale fractal phenomena can beat CITES of the paper, rather than the paper? You think this problem is unstudied, unsolved and unsolvable? Firstly, using CRM - do you believe that these are developed without reference to empirical principles? Also cloud parameterization uses both CRM results AND observation results. The problem with reliance on observational results is that you cannot extrapolate with much certainty outside the range of observation parameters whereas a model from basic principles allows more confidence. I am sure you would be highly critical of parameterizations that extrapolated from observations.

Also NS. Do you suppose that if NS turns up in engineering, we are forced to shrug shoulders and walk away? Of course not - there is massive toolkit for dealing with NS. And yes, this can involve trading confidence for


April 2016 failed to relieve severe pain.

READ MORE:

* ACC claimant says he will never give up fighting

* Ex reviewer of ACC claims fired for using 'inconsistent fonts'

* Thousands of ACC 'independent' reviews invalid, lawyers say

* ACC refuses to increase payments to burns victim

* ACC claimant 'devastated' after signing over her payout to advocate

* Denied ACC claimants urge Government to act

* ACC: An unequal playing field?

Four months after the surgery, an ACC-funded independent medical assessor said Stryder could resume full-time "light to moderate" work duties, but should limit "heavy lifting, pushing, pulling or carrying on a more frequent basis for the medium term".

Stryder objected to this, and two further ACC-funded medical assessments, citing his ongoing pain and reports from his own sports doctors.

Documents supplied to Stryder by ACC lastsaid concerns that Stryder was fraudulently receiving weekly compensation justified the need for video surveillance.

"Even after proof of failed back surgery their doctors are still saying I am fit for 40 hours' work a week doing landscaping, labouring and heavy physical work and they will not listen to my treating doctor, my GP," Stryder said.

In total, ACC spent $3200 on video surveillance and about $19,500 on lawyers to represent ACC at reviews of decisions on Stryder's entitlements. It spent another $1500 for security at a review he had with dispute resolution service FairWay Resolution Ltd.

Stryder believed he was still being watched, but ACC denied that.

"I don't doubt it, they are just trying to exit me any way they can," he said.

SPENDING TO SAVE?

JOSEPH JOHNSON/STUFF ACC says it saved


taxpayers $7.3 million in fraudulently gained weekly compensation through its fraud unit, which uses video surveillance of claimants.

An ACC spokesman said the agency spent $5.1m on its integrity services unit, which investigated 698 cases, in the 2017-18 year. Of those, 427 involved fraud, waste or abuse and 58 were assessed as fraud.

Just over $105,000 was spent on private investigation services for the same period.

Of the 58 cases assessed as fraud, 53 involved fraudulently gained weekly compensation, and social and vocational services. Five cases involved fraudulently gained treatment payments by treatment providers.

ACC prosecuted six people, five of whom pleaded guilty and one case was withdrawn. Other consequences for fraud included formal warning, debt penalties, and ceased or reduced entitlement.

The value of current and ongoing weekly compensation gained from fraudin the last financial year – $7.3m – was calculated using claim history to model expected client claim durations and costs, ACC said.

Lawyer Peter Sara, who represents Stryder, disputed the $7.3m figure.

JOSEPH JOHNSON/STUFF Stryder, 44, has had a tumultuous relationship with ACC since injuring his back at work in April 2014.

"That kind of figure is made up ... it's not a hard figure, it's speculative."

Sara said ACC needed to learn how to better deal with people like Stryder.

"Like a number of people who have had unhappy dealings with ACC, they get mad as hell and that can lead to ... nothing less than warfare."

ACC defended the figure, saying the value of its integrity unit "intervention" was calculated based on claim history modelling.

In the financial year to June, ACC


and applied to appeal three review decisions in the district court. He has been barred from communications with ACC case managers and trespassed from dispute resolution service Fairway Resolution Limited premises.

JOSEPH JOHNSON/STUFF Stryder, pictured with mother Nelly Barr, recently discovered he had been spied on by ACC.

The financial stress, severe back pain, insomnia and challenging of ACC caused his marriage to break down and he suffered from anxiety and depression, he said.

"I hate it when ACC don't believe you. I'm going to have to keep battling with them; I believe it's totally criminal behaviour."

ACC BY THE NUMBERS*:

1.98 million new claims received

79,648 new weekly compensation claims received

$69m - spending on injury prevention

$1.7 billion - spending on treatment and emergency travel

$740m - spending on care and support

$1.4b - spending on1. Technical Field
The present invention relates to a magnetic field measurement apparatus using light.
2. Related Art
Some magnetic field measurement apparatus using light measure a very weak magnetic field, such as a magnetic field from the heart (magnetocardiogram) and a magnetic field from the brain (magnetoencephalogram), and are expected to be applied, for example, to medical image diagnosis apparatus. To measure a very weak magnetic field, it is necessary to remove influence of earth magnetism and other magnetic noise. JP-A-2009-162554 describes an atomic magnetism sensor that allows high-sensitivity measurement of a magnetic field gradient by converting a difference in magnetic field intensity between different measurement positions into a difference in the angle of rotation of polarization of laser light for probing linearly polarized light.
The atomic magnetism sensor described in


Under Minnesota
law, a procedural default can be overlooked "[i]n limited situations, if fairness so
requires and if the petitioner did not 'deliberately and inexcusably' fail to raise the issue
on direct appeal," Roby v. State, 531 N.W.2d 482, 484 (Minn. 1995), quoting Bangert
v. State, 282 N.W.2d 540, 545 (Minn. 1979); see also Townsend, 582 N.W.2d at 228.
After Scruggs, the Minnesota Supreme Court, in Hale v. State, 566 N.W.2d 923, 926
(Minn. 1997), explained that the Scruggs court had simply "exercised its discretion to
review in the interests of justice." In this case, the Minnesota courts evidently
concluded that the interests of justice did not warrant excusing Mr. Murray's procedural
default, and this determination is entitled to respect by our court.

       Because "[a] federal court conducting habeas corpus review(emphasis added). Today, the current panel declares that the Minnesota courts
have "consistently" followed a rule that bars post-conviction consideration of matters
raised or known at the time of direct appeal. Slip op. at 4 (citing State v. Knaffla, 243
N.W.2d 737, 741 (Minn. 1976)).

      The majority fails to appreciate that while the Knaffla rule has been applied to
various post-conviction matters for over twenty years, its specific application to claims
of ineffective assistance of trial counsel has been far from consistent. Just consider the
three cases offered by the panel to support its consistency claims. In Townsend v.
State, 582 N.W.2d 225 (Minn. 1998), no evidentiary hearing was ever held on
Townsend's ineffectiveness claims because the Minnesota Supreme Court could point
to specific evidence that petitioner and counsel were aware of


would remand this action for an evidentiary hearing on Mr. Murray's claim
of ineffective assistance of trial counsel.

      Even though the unpublished opinion of the Minnesota Court of Appeals is not
precedent, nonetheless it forecloses this petitioner from any opportunity to establish his
claims of ineffective assistance of trial counsel. If Minnesota courts continue to refuse
post-conviction remedies without adequate procedures, as in this case, then the Great
Writ of Habeas Corpus stands as a remedy.

       A true copy.

              Attest:

                 CLERK, U.S. COURT OF APPEALS, EIGHTH CIRCUIT.

      are desperate to keep your seat. This is not a gravy train they wish to disembark from.

It certainly explains the tendency to lean to the right in such arguments. The same goes for full time, unelected, trade union officials. They don't want to rock the boat with employers any more than they have to, because they have their own income to protect. Again, it's not to say that none of them care about the workers they represent, it's just that it does explain the tendency to want to avoid fighting for what is right.

All union officials should be workplace based and elected by the members. That way, if the members do not agree with their actions they can be removed from the post and go back to their


the mass majority of Labour Party members and supporters actually believe in, but have been too afraid to express in fear of losing the 'middle ground' to the Tories. He is also someone who can carry forward arguments with the general public in a convincing fashion, and can attract a mass activist base to the Labour Party.

I won't be joining the Labour Party, but I am part of the wider labour movement. As such, I will be voting for Jeremy Corbyn. I will be voting for hope.sy = -sy;
    }

    // Remove scale from matrix
    m.scale(1.0 / sx, 1.0 / sy);

    // Compute rotation
    double angle = atan2(m.b(), m.a());

    // Remove rotation from matrix
    m.rotate(rad2deg(-angle));

    // Return results
    sr[0] = sx;
    sr[1] = sy;
    sr[2] = angle;
    sr[3] = m.a();
    sr[4] = m.b();
    sr[5] = m.c();
    sr[6] = m.d();
    sr[7] = m.e();
    sr[8] = m.f();
}

static void affineTransformCompose(AffineTransform& m, const double sr[9])
{
    m.setA(sr[3]);
    m.setB(sr[4]);
    m.setC(sr[5]);


the network value of a customer, which is
the expected number of other customers that that customer will
directly or indirectly convert, and found that it was often huge. For
example, in the "web of trust" of the Epinions review site, which we
mined, the network value of the top user was over 20,000. That was
pretty exciting! And today's social networks take it to a whole other level.

I think the social influence ranking industry has a great future - the
power of traditional mass marketing and direct marketing is waning,
and increasingly social influence is what determines the fate of your
product. Having said that, the industry is still in its infancy - a
lot of the modeling is still quite ad hoc, as far as I can tell, and
misses a lot of important effects. Butpicked without replacement from {w: 1, s: 1, r: 1, y: 1, v: 1}. Give prob of sequence rswy.
1/120
Two letters picked without replacement from {j: 1, h: 2, p: 1, c: 1, n: 1, g: 1}. Give prob of sequence nh.
1/21
Two letters picked without replacement from {t: 15, h: 3}. What is prob of sequence ht?
5/34
Calculate prob of sequence hkqq when four letters picked without replacement from {k: 2, q: 4, h: 4}.
2/105
What is prob of sequence yc when two letters picked without replacement from cycchyyzyhh?
6/55
Calculate prob of sequence uv when two letters picked without replacement from {u: 1, v: 1, b: 2, t: 2}.
1/30
Two letters picked without replacement from {k: 13, f: 1, z: 3}. What is prob of sequence zz?
3/136
Four letters picked without replacement from hmmmmhmmmmmmmh.


What is prob of sequence hhhm?
1/364
Calculate prob of sequence ma when two letters picked without replacement from {m: 1, l: 1, i: 1, a: 2}.
1/10
Calculate prob of sequence tt when two letters picked without replacement from {e: 9, t: 2}.
1/55
What is prob of sequence cbbr when four letters picked without replacement from bcbcccrccccbccccc?
13/9520
Four letters picked without replacement from qqjqqjbjqjqjqj. Give prob of sequence qqqj.
15/286
Four letters picked without replacement from yyyy. What is prob of sequence yyyy?
1
Two letters picked without replacement from {h: 1, m: 1, b: 1, p: 2, z: 2, e: 1}. Give prob of sequence ze.
1/28
What is prob of sequence rn when two letters picked without replacement from yernsery?
1/28
Calculate prob of sequence vv when two letters picked without replacement from oooovov.
1/21
What is prob of sequence pfpwhen three letters picked without replacement from {c: 1, f: 1, p: 7}?
1/12
Three letters picked without replacement from {c: 2, s: 7, a: 11}. What is prob of sequence sca?
77/3420
What is prob of sequence llkk when four letters picked without replacement from {l: 13, k: 5}?
13/306
Calculate prob of sequence apga when four letters picked without replacement from fgggudpuauagafgaapaa.
7/1938
What is prob of sequence dgh when three letters picked without replacement from doghgdou?
1/84
What is prob of sequence ul when two letters picked without replacement from quslsuu?
1/14
Four letters picked without replacement from fxpppfomzomm. Give prob of sequence fopo.
1/990
Three letters picked without replacement from {v: 2, j: 1, y: 2, p: 1, t: 1, f: 1}. What is prob of sequence jvf?
1/168
Calculate prob of sequence pk when two letters picked without replacement


lipoic acid supplementation in subjects with impaired glucose tolerance (IGT) or diabetes type 2 (DM2), who are characterized by increased oxidative stress^[@CR8],[@CR9]^. These two antioxidants were chosen, since vitamin E is a typical fat-soluble antioxidant, while lipoic acid is fat- and water-soluble antioxidant and both have been shown to lower oxidative markers in type 2 diabetics^[@CR10],[@CR11]^.

Results {#Sec2}
=======

Average daily intakes of energy, fiber, and cholesterol, and the proportions of energy from protein, carbohydrates, total fat, saturated fatty acids, monounsaturated fatty acids, and polyunsaturated fatty acids, and habitual vitamin E intake in the background diet did not differ between the three periods (Supplemental Table [1](#MOESM1){ref-type="media"}). Plasma vitamin E concentrations were measured at the end of the three periods (Supplemental Table [2](#MOESM1){ref-type="media"}). Plasma vitamin E concentrations were 21.0 ± 9.2 μg/mL higher at the end ofin the text.

Correlations {#Sec3}
------------

In the control period, positive correlations were found between plasma 7α-OH-campesterol and 7α-OH-sitosterol concentrations (r = 0.845; P \< 0.001), between 7β-OH-campesterol and 7β-OH-sitosterol concentrations (r = 0.625; P = 0.004), and between 7-keto-campesterol and 7-keto-sitosterol concentrations (r = 0.902; P \< 0.001). Although plasma concentrations between the different oxyphytosterol isoforms also correlated significantly, correlations were less strong than between similar isoforms. Also in RBC's and platelets, oxycampesterol and oxysitosterol levels were correlated, although stronger correlations were seen in platelets compared with RBC's (Table [4](#Tab4){ref-type="table"}). Plasma and RBC oxyphytosterol levels, plasma and platelet oxyphytosterol levels and RBC and platelets oxyphytosterol levels did not correlate.Table 4Oxyphytosterol correlations within plasma and within tissue (RBC's & platelets) in control period (n = 20).ParameterParameterCompartmentCorrelation\*P-value7α-OH-campesterol7α-OH-sitosterolPlasma0.845\<0.0017β-OH-campesterol7β-OH-sitosterolPlasma0.625\<0.017keto-campesterol7keto-sitosterolPlasma0.902\<0.0017α-OH-campesterol7β-OH-campesterolPlasma0.4420.0587keto-campesterolPlasma−0.4080.0837β-OH-campesterol7keto-campesterolPlasma−0.0710.7737α-OH-sitosterol7β-OH-sitosterolPlasma0.678\<0.017keto-sitosterolPlasma−0.0670.7857β-OH-sitosterol7keto-sitosterolPlasma0.538\<0.0157α-OH-campesterol7β-OH-campesterolRBC0.922\<0.0017keto-campesterolRBC0.3900.1107β-OH-campesterol7keto-campesterolRBC0.4200.0807α-OH-sitosterol7β-OH-sitosterolRBC0.798\<0.0017keto-sitosterolRBC0.4400.077b-OH-sitosterol7keto-sitosterolRBC0.3400.1527α-OH-campesterol7β-OH-campesterolPlatelets0.577\<0.017keto-campesterolPlatelets0.746\<0.0017β-OH-campesterol7keto-campesterolPlatelets0.653\<0.017α-OH-sitosterol7β-OH-sitosterolPlatelets0.809\<0.0017keto-sitosterolPlatelets0.741\<0.0017β-OH-sitosterol7keto-sitosterolPlatelets0.794\<0.001\*Correlations in plasma concentrations were determined with Pearson's correlation and correlations in RBC and platelet levels were determined with Spearman's rho


implications of higher oxyphytosterol concentrations in IGT or type 2 diabetic subjects remain to be determined.

Methods {#Sec5}
=======

Study population {#Sec6}
----------------

The study population consisted of 20 men and women with IGT or type 2 diabetes. Subjects attended two screenings visits to assess their eligibility before entering the study. These criteria included an age between 18 and 75 years, BMI between 20 and 35 kg/m^2^, no active cardiovascular disease or severe medical conditions that might interfere with the study, no use of insulin or lipid-lowering medication, mean serum total cholesterol \<8.0 mmol/L, mean serum triacylglycerol \<3.0 mmol/L, diagnosed with diabetes mellitus type 2 on a clinical basis or IGT. The diagnosis of type 2 diabetes or IGT was based on the use of oral hypoglycemic agents or an oral glucose tolerance test. Only subjectsIf you tap the top of a soda can, will it really keep it from foaming when you open it?

Those who think so follow this logic: When you shake a soda can, little molecules of carbon dioxide bump into each other and form bubbles. These bubbles hang around on the sides and bottom of the can until you pop the top, at which time they shoot out, eager to escape to the lower air pressure outside the can. Some liquid clings to them on their way out—and winds up all over your shirt. Tapping the can prior to opening it, the theory goes, dislodges bubbles from the bottom and sides. The bubbles join the big pocket of gas at the top, which escapes harmlessly because it’s above the


points preoperatively to 81.5 points postoperatively). CK Lu \[[@CR11]\] reported that 13 feet of 13 patients with patients with Müller-Weiss disease with a mean age of 55.6 years were received the isolated talonavicular arthrodesis. The average modified American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot score improved from 48.5 points preoperatively to 87.2 points at final follow-up (mean 51 months, range 10--114 months). Three cases were nonunion. In our study, either the isolated talonavicular arthrodesis or talonavicular-cuneiform (TNC) arthrodesis was gained the good clinic results and the solid fusion.

Conclusions {#Sec7}
===========

Throughout, the main limitation of the current study is the small number of cases; either TN or TNC arthrodesis for stage III or IV Müller-Weiss disease according to MRI evaluation have the good clinical outcomes with solid fusion rate and obviousvalue of ((-3)/136)/(867/(-68782))?
7/4
What is the value of -21 + (77/(-2772) - (-17087)/828)?
-9/23
What is (11/(-22) + 2)*(-7)/84*-40?
5
What is the value of (1530/595)/(20511/301)?
2/53
What is (0 + 3 + 1*5)/(221650/(-1705))?
-4/65
What is 1 + -69 + ((-3250)/(-4875))/((-4)/18*-3)?
-67
-12 + 5824/117 + 240/108
40
Evaluate -72 + (-8381)/(-116) - 7/60.
2/15
What is (6 - -33) + (53694872/(-24589))/56?
2/367
What is 51/(-27) + 2 + ((-2384)/396 - -6)?
1/11
What is the value of (-2780)/(-1946) + 3104/(-56)?
-54
(240/(-280))/(-2*(-15)/3920) - 25
-137
What is the value of (-1920)/(-7744)*-11*(-3)/5?
18/11
Evaluate (((-10)/8 + -1)/((-1071)/1428))/(-12).
-1/4
((-1710)/38)/(-15) + 47
50
Calculate ((-44)/40)/(10 + 1023/(-102)) + 90/150.
38
4/288 + (-1027950)/(-15120) - 34
34
What is 5/(-290)*-4 + (-495)/11803?
1/37
What is the value of ((-1228)/10745)/((-48)/14)?
1/30
-37 - (-3 + 5 + -13 + 21)
-47
Calculate ((-11)/308*35)/(2 - 0)*1.
-5/8
(-5)/(35/77) + -5 + 11 + -31
-36
Evaluate (-47213)/(-24368) - (-5 - (-105)/25)*(-5)/2.
-1/16
What is 2*-5 - (543 - 605) - -4?
56
What is the value of (-5


months. Only one time did I ride the same road twice. I did not touch any of the four main roads crossing the line either. That shows how very logical my route through the South Island has been…

It turned out to be one of those glorious sunny days with hardly any wind and low gradients.

Perfect bicycle touring conditions. We were aiming to catch the ferry at two. The road we were on took us to the south side of lake Wakatipu. From where we could see Queenstown across the other side. But with numerous photo opportunities along the way we never made it in time. So while Richie and I relaxed, had a beer, and talked the young girls at the cafe into giving us free cakes (he’sNeil’s friend. I had no problems cycling up the hills. It was the way down that slightly worried me. I might need some practise at this downhill-thing. But apparently I wasn’t the worst they’ve seen. That’s a compliment I guess.

So that was all excitement in Nelson. Well, that and cutting of my hair.

I agree with Sally, brings back great memories…NZ was also my first cycle tour, thought I’d go for 3 months and only made it on the North Island, so renewed visa and did 3 months on the South Island.
Great pictures!

Hi Mirjam,we throughly enjoyed your company,you are a real inspiration.Penny`s report of you will arrive Sat.Take care in your travels & if you are able to forward an address we will send a copy.Regards Marg & Shaun.Blenheim


Characterization of human sperm N-acetylglucosaminidase.
N-acetylglucosaminidase (NAG) is particularly active in mammalian spermatozoa and appears to be involved in fertilization. Although it is assumed that this enzyme is acrosomal, previous results from our laboratory suggest the presence of NAG at the sperm plasma membrane level. The present study attempted to analyse the subcellular distribution of this enzyme in human spermatozoa. Sperm were incubated under different conditions and NAG activity measured in the soluble extracts and cell pellets using a specific fluorometric substrate. A significant proportion of NAG activity was released when sperm were incubated in culture medium, suggesting a weak association with the plasma membrane. This location was confirmed by western blot analysis of plasma membrane fractions and immunofluorescence on non-permeabilized sperm, which showed a positive signal mainly onillustrated by a plane as shown in Fig. \[fig:3b\]. In reality, the relation is not a perfect plane, but a surface since it is curved at high-$k$ and low-$\ell$ region as shown in Fig. \[fig:2a\]. Importantly, this marks a contrast to a ‘scaling line’ that is implied by the three scaling relationships between pairs of three variables (Fig. \[fig:3a\]). In fact, the bivariate scaling laws found in an earlier study[@Watanabe2013] are naturally interpreted as projections of a single scaling line to the 2-dimensional planes, where the firms are densely distributed[@Klingenberg2016].

Our finding of $\beta > \alpha$ remains true for all years, as shown in Fig. \[fig:4\], where the estimated scaling exponents for different years are plotted. For example, we have $\alpha = 0.49$ (95% confidence interval (CI) $(0.455, 0.531)$) and $\beta = 0.72$


firms on the scaling line should be predominantly determined by growth fluctuations and cannot be attributed to their body or activity sizes.

Although we find no direct relation of exit rate to the surface of multi-variate scaling, the scaling line seems to be relevant also to the exit rate of firms, namely, the rate of bankruptcy, merger and suspension or closure of business. For firms of medium or large size, the exit rate exhibits a clear decline around the scaling point (Fig. \[fig:7\]; also see Supplementary Fig. \[fig:s10\]). Exit rates are often relatively high for firms that are distant from the scaling line, and at some regions the rates are significantly high, exceeding 3 per cent per year. On the other hand, they are quite low (less than 1 per cent perfor understanding other natural or technological complex organizations.

Presenting novel stylized facts, we believe that our results are also beneficial for future modeling and theory construction. Researchers have formulated numerous models[@Buldyrev1997; @Bottazzi2003; @Alfarano2012; @Gallegati2003; @Wright2005; @Fu2005; @Riccaboni2008; @Mondani2014; @Takayasu2014; @Malcai1999; @Sutton2002; @Wyart2003] to explain a few stylized facts on firms and new criteria were apparently needed to discriminate and validate the models. Thus, we suggest that future theoretical studies should incorporate the phenomenological multi-variate evolution of firm entities found here. Theories for scaling relations between sizes in other complex systems such as animal bodies and cities might be relevant to this enterprise, because fractal-like hierarchical organization is a pervasive design in all these systems[@Li2015a; @West1997; @Batty1994; @Fix2017]. This might open a prospect of devising general understandings and modeling principles


crept towards the inner edge. Similar walkways ran along the same pathway both above and below. He peered over the railing. The gaming floor stood far below.

Halren imagined what it would be like to fall from this height. The world around him began to spin. He shoved himself away from the railing and sat on the floor and waited for the dizziness to pass.

Once he recovered, he walked along the outer wall, avoiding looking towards the center of Bolrinia. Doors with numeric symbols lined the outer wall. Halren looked for the symbols matching those on Valestra’s tarot.

When he found the room, a short purple skinned creature blocked his way. The creature had long pointed ears and only a few thick black hairs on its head. It wasn’t much21*i**2 - 4*i + 3. Determine u(8).
291
Let l(n) = 2*n**3 - 58*n**2 - 67*n + 194. Calculate l(30).
-16
Let p(q) = 842*q + 306. What is p(-1)?
-536
Let w(i) = 35*i + 76. Give w(-10).
-274
Let u(a) = -110*a**2 - 1100*a - 1. What is u(-10)?
-1
Let g(w) = -3*w**2 + 114*w - 117. Determine g(37).
-6
Let b(m) = 3*m**3 - 16*m**2 - 6*m + 56. Determine b(5).
1
Let v(h) = h**3 + 44*h**2 + 37*h - 248. Calculate v(-43).
10
Let w(f) = 18*f + 502. Calculate w(-28).
-2
Let a(u) = 22*u - 99. Calculate a(22).
385
Let c(y) = -5*y**2 - 76*y - 25. Calculate c(-21).
-634
Let y(g) = -g**2 + 26*g - 121. Give y(19).
12
Let d(p) = -23*p + 51. Give d(9).
-156
Let q(a) = 43*a**2 + 47*a - 45. Give q(1).
45
Let o(z) = -z**3 + 67*z**2 -


a master-oscillator power amplifier that uses optical fibers.

The laser beacon to DSOC will be transmitted from JPL's Table Mountain Facility located near the town of Wrightwood, California, in the Angeles National Forest. DSOC's beaming of data from space will be received at a large aperture ground telescope at Palomar Mountain Observatory in California, near San Diego.

Biswas anticipates operating DSOC perhaps 60 days after launch, given checkout of the Psyche spacecraft post-liftoff. The test-runs of the laser equipment will occur over distances of 0.1 to 2.5 astronomical units (AU) on the outward-bound probe. One AU is approximately 150 million kilometers-or the distance between the Earth and Sun.

The Psyche mission was selected for flight in early 2017 under NASA's Discovery Program, a series of lower-cost, highly focused robotic space missionsthat are exploring the solar system.

The spacecraft will be launched in the summer of 2022 to 16 Psyche, a distinctive metal asteroid about three times farther away from the sun than Earth. The planned arrival of the probe at the main belt asteroid will take place in 2026.

Lindy Elkins-Tanton is Director of the School of Earth and Space Exploration at Arizona State University in Tempe. She is the principal investigator for the Psyche mission.

Elkins-Tanton adds that bringing robotic and human spaceflight closer together is critical for humankind's space future. "Having our robotic mission test technology that we hope will help us eventually communicate with people in deep space is excellent integration of NASA missions and all of our goals," she says.

In designing a simple, high-heritage spacecraft to do


Blockchain technology has emerged as a tool for addressing an important global issue: the growing complexity of the food supply chain and the increasing amount of wasted food, according to a senior research fellow at the University of Surrey.

Writing in The Conversation, an online source of information from the academic and research community, senior research fellow, Phil Godsiff said that a recent analysis suggested that half of U.S. food production is wasted, with global estimates above 30 percent.

The growing use of sensors in the food supply chain, paired with blockchain technology, could reduce food waste and make food data more transparent through the supply chain.

Food Supply Chain in Crisis

Retailers want perfect produce, leading to waste throughout the food supply chain. They also seek low prices, which has resultedhere by creating a sense of rising condensation in the air.

The trailer also boasts new screen-space reflections for this special edition, but this isn't a massive visual boost per se. In fact, the current PC version already has reflections on floors and walls at the same quality, with light-emitting spells mirrored on most surfaces. The only change is a subtle lens flare effect that plays across light points, something that's missing outright from the original game. Of course, a similar effect can be achieved on PC already - alongside many of the Special Edition enhancements we've mentioned- with ENB mods widely available online.

For this very reason, the option for user-made mods in Skyrim: Special Edition is a massive win on PS4 and Xbox One. Similar to its console


Up" is a treacly ballad designed for maximum uplift, with a gospel choir, swelling choruses and messages of comfort and encouragement. "Not gonna lie and say I understand," Kelly sings. "I just wanna be here for you if I can / To hold your hand and be by your side / And together we will get through these times."

That there would be a major artist memorializing the Virginia Tech tragedy is hardly a surprise. That the tribute came from R. Kelly and not, say, the noted pop healer Elton John, was at least a little unexpected, given Kelly's rep as modern soul's sultan of strange -- a singer of sex-obsessed songs who happens to be awaiting trial on child-pornography-related charges.

Then again, Kelly has shown a more earnest, inspirationalBrazil, a good MLS season could see Casseres debut for the senior team on the biggest South American stage. If the call does indeed come, he is confident that Venezuela are better placed than ever to compete with the likes of Brazil and Argentina. “I am 100 percent sure that we will be very well prepared for this. This Copa is going to be the best we’ve done, it is going to be in the history books, of that I’m sure.”

Venezuela have been drawn in the same group as the hosts, and Cásseres believes they are in possession of the best player he has coming up against on the pitch in Real Madrid’s Vinícius Júnior. Should they progress out of the group they may well come up against


several of our senior players in Europe make us an interesting team, which is undoubtedly capable of making the finals. We have the technique and leadership that we lacked years ago.”

Some magazines are meant to be kept

If La Vinotino are to succeed in the coming years, they do so against the current backdrop of civil unrest. Though inflation is slowing down – it practically halved from 97 percent in January to 47 percent in February – the country is still in a state of hyperinflation. The president, Nicolás Maduro, is still unpopular with many, but even more unpopular is the recent American intervention – nobody on either side of the internal debate wanted that. “The fact that the US is involved now is one of the worst thingsother infrastructures and services depend."

The U.S. House of Representatives unanimously voted on a plan to install power-surge protectors throughout the North American power grid, but the plan was killed by the U.S. Senate.

"As only politicians can, they dashed the hopes of a healthy civilization. The Senate subcommittee stripped out the language so they couldn't even vote on the matter," says Joseph, who can barely contain his rage on the issue.

"The good news and the irony is that we can do something about it. It's not just another ‘Oh my God, we're going to die' scenario."

But it appears that the window of opportunity to prepare has passed, leaving us vulnerable to the whims of the sun.

"It's going to happen, the question is when? The next red zone for the


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Tuesday, October 14, 2014

What I Ate: Cool weather calls for pho

I'm relishing the few "cold fronts" we've been gifted with this week a bit too much with bowls of pho. The week also included stops at Freetail's new brewery, along with review visits to Folc.
Follow me on Instagram for more treats: @JessElizarraras.red, yellow and green lights, so that the train engineer has some indication of the condition of the tracks down the line. Moreover, a switch house is usually located at each railroad crossing for providing warnings to traffic crossing the railroad tracks if a train is approaching.
The equipment stored inside each of these switch houses may vary, depending on the kinds of signals that are to be monitored and regulated. However, each of the equipment stored in each of the switch houses tends to be electrical or electronic in nature, and accordingly could be affected by power surges resulting from transients from the power line or lightenings that strike either the railroad tracks adjacent to the house or the house directly. And when the equipment malfunctions, the signals


composition of the oils used in preparing diets was analyzed and it was found that all the oils had a rather similar composition, mainly oleic and linoleic acids ([Table 2](#tab2){ref-type="table"}).

The animals were divided into two groups: a control group (CG, *n* = 5) receiving a basal diet and a sucrose-fed group (S, *n* = 20) which received the basal diet plus 30% sucrose solution as drinking water. The animals had free access to food and water for 16 weeks and food intake was measured daily. At the end of this period, the diet was withdrawn for at least 4 hours and the manifestation of the metabolic characteristics was checked by first determining body weight, then serum glucose, triglycerides, and cholesterol levels by cardiac puncture.

Once the sucrose-fed model hadshowed changes in total protein levels, all of them significantly higher (*P* \< 0.05) than control group (CG). Additionally, direct bilirubin levels in S-OO and S-AOC groups decreased (*P* \< 0.05) in relation to CG and S groups, but not for the S-AOS group, where a nonsignificant decrease was observed. Albumin and globulin levels in S-OO, S-AOC, and S-AOS study groups were not found to be significantly different either from S or CG groups.

3.3. Effect of Dietary Oils on Pancreatic Function Biochemical Markers {#sec3.3}
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The effect of dietary olive and avocado oils on pancreatic function indicators is shown in [Figure 2](#fig2){ref-type="fig"}. Levels of glutamic oxaloacetic transaminase (GOT) in S-AOC and S-AOS groups were similar and not significantly different than either the S or CG group. Significantly lower levels were


rats were similar to those in the CG group and not significant. Reaven and Chang \[[@B17]\] have suggested that this is due to hyperinsulinemia developed in metabolic abnormalities which maintains normal levels of blood glucose. TG levels were significantly higher (56%) in S group rats (a 2.3-fold increase). Other studies have found similar results \[[@B18], [@B19]\]; Piatti et al. \[[@B20]\] reported the association in healthy patients between sudden TG elevation and insulin resistance and suggested that the increase in blood TG*in vivo* inhibits glucose utilization and oxidation stimulated by insulin action in the peripheral tissues. One way to explain the blood TG elevation might be to consider a possible increase in the reesterification of fatty acids from the liver as a result of fructose metabolism as reported byin rats fed with different oil diets: a) total protein; b) albumin; c) globulin; d) direct bilirubin. Corn-canola diet plus 30% sucrose in drinking water (S group, *n* = 5); olive oil diet plus 30% sucrose in drinking water (S-OO group, *n* = 5); avocado oil diet extracted by centrifugation plus 30% sucrose in drinking water (S-AOC group, *n* = 5); avocado oil diet extracted by solvent plus 30% sucrose in drinking water (S-AOS group, *n* = 5). Values are mean ± SD. \**P* \< 0.05; \*\**P* \< 0.01 versus corresponding data in CG group.](BMRI2014-595479.001){#fig1}

![Blood serum profile levels of liver function markers in rats fed with different oil diets: a) GOT; b) GPT; c) Alkaline phosphatase; d) Cholinesterase; e) *α*-amylase. Corn-canola diet (CG group, *n* = 5); corn-canola


More than $ 100,000 was raised for a young girl from Massachusetts who contracted a potentially deadly Eastern Equine Encephalitis (EEE) virus earlier this month, according to an online fundraiser for the girl's name.

As of this writing, $ 146,133 was raised for Sofia Garabedian, a 5-year-old Sudbury girl who was admitted to a children's hospital in Boston with sudden and severe flu-like symptoms, including headaches, on September 3. The goal of the fund is $ 200,000.

FIFTH CASE OF A DEATH-STUDY VIRUS VIRUS IN MASSACHUSETS, 3 COMMUNITY DOSAGE AT "CRITICAL RISK"

The girl who suffered from brain swelling is a medical diagnosis such as eutheremia. a woman under 1

8 was later confirmed by the Massachusetts Department of Health, with local shopping malls reporting that she was a 5-year-old girl fromDescription

DOOM is a reboot of the first-person shooter series and it consists of three parts, accessed and loaded separately from the main menu: a single-player campaign, multiplayer with different game modes, and the SnapMap editor where custom maps and game modes can be created and shared. While many elements of the series are revisited, the focus for this entry is on fast gameplay based on movement, fights switching between different weapon combinations, and violent gameplay with brutal finishers, more akin to the first games. Compared to DOOM³ the areas are wider with more focus on verticality and rewarding an offensive approach, doing away with the slower horror aspect based on scares.

The single-player campaign consists of thirteen levels. It is set on Mars on a research facility of Union


kills. When enemies receive a certain amount of damage they stagger with a blue highlight. When close enough they turn orange and a dynamic glory kill finisher can be performed, different based on the angle. These glory kills can often be used to chain attacks together. Melee attacks are also possible as well as using explosive items in the environment. The chainsaw weapon has a specific use. It requires fuel and does a lot of damage, with fuel consumption based on the strength of the enemy. A chainsaw kill is rewarded with additional ammo for the regular weapons. Through optional rune trials in levels a large number of runes can be earned that can be equipped in a small amount of slots.

Multiplayer game modes include team deathmatch (killQ:

Why did Run best_estimator_ from GridSearch using cross-validation produce different accuracy score?

Basically, I want to perform binary classification using SVM (SVC) from sk-learn. Since I do not have separate training and testing data, I use cross-validation to evaluate the effectiveness of the feature set that I use.
Then, I use GridSearchCV to find the best estimator and set the cross-validation parameter to 10. Because I want to analyze the prediction result, I use the best estimator to perform cross-validation using the same dataset (of course I use 10-fold cross-validation).
However, when I print the scores of performance (precision, recall, f-measure, and accuracy), It produces different scores. Why do you think this happen?
I am wondering, in sk-learn should I specify the label for positive one? In my dataset,


       color_idx.setdefault(Y[i][0], [])
        color_idx[Y[i][0]].append(i)

    for c, idx in color_idx.items():
        plt.scatter(node_pos[idx, 0], node_pos[idx, 1], label=c)
    plt.legend()
    plt.show()

if __name__ == "__main__":
    G=nx.read_edgelist('../data/wiki/Wiki_edgelist.txt',
                         create_using = nx.DiGraph(), nodetype = None, data = [('weight', int)])
    model = Node2Vec(G, walk_length=10, num_walks=80,
                     p=0.25, q=4, workers=1, use_rejection_sampling=0)
    model.train(window_size = 5, iter = 3)
 63% (retrospective CT interpretation), while specificity ranged from 77% to 93%. The most common cause of high-attenuation bile in the series was sludge, a cause not previously reported. It was concluded that intracholecystic bile is poorly evaluated on routine abdominal CT, particularly because of low sensitivity in disease detection.


William Barr. Paul cited concerns about Barr's stance on warrantless surveillance.

On Saturday night, Paul reportedly praised Trump in his speech to about 200 Kentucky Republicans, the Bowling Green Daily News reported, before turning abruptly to announce his opposition to the president's emergency declaration.

"We may want more money for border security, but Congress didn't authorize it," Paul said. "If we take away those checks and balances, it's a dangerous thing."

Android and Windows Phone collide in China as market explodes - stevep2007
http://www.networkworld.com/community/blog/android-and-windows-phone-set-collide-china#!
An astounding 450 million smartphones will ship in China in 2014, which amounts to approximately a third of worldwide shipments. It also means that next year, one in every three Chinese men, women and children will buy a smartphone. China is a tantalizing target for Apple, Microsoft and Google.<p>Microsoft VP of Advertising and Online Frank Holland said: "We are going to spend a lot of time in the next 12 months building a real presence on the low-end smartphone market with developing countries."
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Will Microsoft be giving away Windows Phone, or suing Android manufacturers to
increase the price of the competition?