which coincided with the incident is known to pose challenges for radar operators who must interpret images on their screens. He believes that the phantom images spotted on radar were not of Vietnamese war vessels but American aircraft. While it may sound far-fetched to think that the two could be confused, the nature of radar in 1964 was such that such misidentifications were not uncommon, usually under certain weather conditions—conditions that were recorded on the evening of the "attack." Moïse writes: "Normally one would think it impossible for airplanes to be confused with surface vessels on radar, since the slowest airplane moves so much faster than the fastest surface vessel. Commander George Edmondson...confirms that such confusion can occur in weather of the sort he remembers encountering on theData + Layer-wise is the combination of target data adaption and layer-wise discriminative training

\[knowledge\_transfer\_step\]

Conclusion {#sec:conclusion}
==========

In this work, we investigated three important aspects of MPC. Pre-training data with matching speaking style was found to be more useful on downstream recognition tasks. Using MPC directly on streaming models helps, but combining MPC with APC brings further improvements on streaming models. Also, the combination of target data adaption and layer-wise discriminative training provides consistent gains on knowledge transfer to downstream tasks.


& North Western Railway Company, were part of his regular duties as such surgeon, and included in the salary he received from the railway company. The tendered instruction was that if the jury found by a preponderance of the evidence that appellee was employed by the railway company to treat the appellant's children, he could not recover against appellant. The evidence is that at the time important to this controversy appellee was engaged by the Chicago & North Western Railway Company as division surgeon for it and its subsidiary, Chicago, St. Paul, Minneapolis & Omaha Railway, on a salary to care for, when he was available, injured employees and passengers who received injury in transit on the lines of these companies. Appellee received nothing from the companies, or// source: book.proto
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reader into the given message object.
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      msg.setTitle(value);
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and had a foul odor." Id. O'Brien also observed "a vicious pit bull chained up in the backyard that had access into the kitchen" of the apartment. Id. at 58. When O'Brien commented on the condition of the apartment, Herrera "responded by stating that she was in the process of moving out." Id. at 31. When O'Brien questioned Herrera about the "state of the tub," Herrera "informed [O'Brien] that the tub had been backing up and that they had spoken to the landlord about the situation." Id. at 32. Herrera also claimed to have "been using someone else's bathroom to bathe her child."[1]Id.
O'Brien decided, based upon the unsanitary conditions of the apartment, to contact New Mexico's Child, Youth & Families Department (CYFD). A CYFD worker arrived on thescene and paramedic services were contacted in order to check the health of Herrera's son. The paramedic examination indicated that the child was in good health. O'Brien also contacted the City of Albuquerque's nuisance abatement officials based on her concerns that the apartment complex was not up to city code.
Ultimately, O'Brien arrested Herrera for violating New Mexico's child abuse statute, N.M. Stat. § 30-6-1. O'Brien did so because she was concerned that Herrera's son "could hurt himself by picking up the razor blades that were on the floor, ingesting the cigarette butts on the floor, being attacked by the pitbull in the kitchen or drowning in the sewage that was in the bathtub." Id. at 153. O'Brien was also concerned "that the child could have sustained an infection


district court expressly noted in its order granting summary judgment for Herrera "that whether... O'Brien had probable cause to arrest [Herrera] was a `close case,'" and "[b]ecause th[e] case [wa]s a `close case' it would not have been clear to a reasonable officer what the law required." Id.
In her response to defendants' motion for reconsideration, Herrera argued, in pertinent part, that
because the existence of probable cause [wa]s the determinative factor in both an unlawful arrest analysis as well as a qualified immunity analysis, and ... because *1069 th[e] Court ha[d] already thoroughly examined the probable cause issue and found probable cause to be lacking such that a reasonable officer would realize that the effectuation of an arrest under the circumstances would be unlawful and in violation of bothfor Herrera's arrest (as the district court determined in assessing the first prong of the qualified immunity inquiry), the critical question under the second prong of the qualified immunity inquiry is whether, at the time of the arrest, O'Brien could have reasonably concluded that probable cause existed for the arrest. See Anderson v. Creighton, 483 U.S. 635, 641, 107 S.Ct. 3034, 97 L.Ed.2d 523 (1987) (holding that, under the doctrine of qualified immunity, "law enforcement officials will in some cases reasonably but mistakenly conclude that probable cause is present, and ... in such cases those officials... should not be held personally liable."). Necessarily, resolution of this second prong inquiry is governed by "cases published before" Herrera's arrest. Swanson, 577 F.3d at 1200. We may "also examine cases published


to a significant risk of harm, `even though the child does not suffer a physical injury.'" State v. Chavez, 146 N.M. 434, 211 P.3d 891, 896 (2009) (italics in original; quoting State v. Ungarten, 115 N.M. 607, 856 P.2d 569, 571 (1993)). Between 1993 and 2009, the New Mexico courts "interpreted the phrase `may endanger,'" as used in § 30-6-1, "to require a `reasonable probability or possibility that the child will be endangered.'" Id. (italics in original; quoting Ungarten, 856 P.2d at 571). "In application, however, this standard ... created uncertainty in child endangerment cases because `probability' and `possibility' connote two different levels of risk." Id. "`Probability' conveys a certain likelihood that a result will occur, whereas `possibility' means that something is merely capable of occurring." Id. "Asrise to a violation of § 30-6-1(D)(1) if the conditions found in Herrera's apartment created the mere "possibility" of harm occurring to Herrera's son. In turn, an officer in O'Brien's position could have reasonably concluded that several of the conditions found to exist in the apartment actually created such a possibility. Specifically, an officer could have reasonably concluded that: (1) the razor blades found on the floor created the possibility of the child cutting himself; (2) the standing waste found in the bathtub created the possibility of the child sustaining an infection or, worse yet, drowning; (3) the cigarette butts on the floor posed a possible risk of the child picking them up and ingesting them; and (4) the pitbull in the yard, which had access to the


"did not preserve th[e] issue for appeal." Ecclesiastes 9:10-11-12, Inc. v. LMC Holding Co., 497 F.3d 1135, 1142 (10th Cir.2007). From the district court's perspective, it was informed by the parties at the time of the November 26, 2008 pretrial conference that they would *1075 attempt to resolve the issue "by stipulation as to a motion to seal [Herrera's] juvenile arrest record." App. at 99. At no point after that time did either side file a pleading addressing the expungement issue. Most notably, Herrera did not mention the request for expungement either in her response to the defendants' motion for reconsideration, or by filing her own motion for relief from judgment after the district court granted O'Brien's motion for qualified immunity and entered final judgment. In short, Herrera  if (hasBeenOffline) {
          interval = setInterval(function() { /* code */ } )
      }
   } else {
      // server offline
      clearInterval(interval)
   }
};

setInterval(loop, 1000);

In this way you will have the a better control of the application flow, and will not be required to create the same interval twice in your code.
Some frameworks use a similiar approach, read about the Ember Run Loop to know more about the concept.


more, lasting 0.08 sec (nST); row number of the minimum lead in the Isointegral map (Imin); number of positive leads on the seventh row in Isointegral mapping (I-7); number of positive leads on the first row in Isointegral mapping (I-1) and I-7/I-1 ratio. Based on these calculations the criteria for detecting myocardial ischemia (nST < or = 2, Imin < or = 2, I-7/I-1 > or = 1) were created and their usefulness was tested using findings of coronary angiography and exercised 201Tl myocardial scintigram as the golden standard. For the diagnosis of ischemic lesion, the DOB stress body surface mapping test in group A had higher specificity (nST: 100%, Imin: 89%, I-7/I-1: 100% vs. 78%) and higher sensitivity (75%, 50%, 63% vs. 38%), than those by thebool )m_data;
    }

    ///If this returns false, a left and a right node are available.
    ///If this returns true, this node represents a single item, that can be retrieved by calling item() or operator*.
    inline bool isFinalNode() const
    {
        return m_data->leftNode() == 0;
    }

    inline T firstItem() const
    {
        return Conversion::toItem(start());
    }

    inline T lastItem() const
    {
        return Conversion::toItem(end() - 1);
    }

    inline T operator*() const


Q:

Android what's Difference between save image to Gallery and SDCARD,And How to save both?

Android how to save image in Gallery? and what's difference between save image to gallery or in sdcard Please Explain ....

A:

You can not really save an image file into the gallery.The gallery is a native android app designed to show the image and video files on the SD card. However,when you save some media files into SD card, you can notify the mediascanservice to update the database of the gallery so that these files will be shown in gallery (by default ,not shown ).
see here:http://developer.android.com/reference/android/media/MediaScannerConnection.html

between a ray and a node then the ray may be tested for intersection with all of the nodes which are children of the intersected node prior to performing the intersection testing for any of those children.
With current state of the art acceleration structures it is difficult to perform the processes involved in ray tracing (e.g. build an acceleration structure, perform intersection testing and execute shader programs in dependence on the results of the intersection testing) at a rate that is suitable for rendering images in real-time (e.g. for use with gaming applications), particularly on devices which have tight constraints on silicon area, cost and power consumption, such as on mobile devices (e.g. smart phones, tablets, laptops, etc.). Furthermore, the acceleration structures need to be stored, e.g. in


a memory, and this can involve storing lots of data, which increases the memory requirements of the system and also means that large amounts of data are transferred between a memory and a chip on which a ray tracing system is implemented. The transfer of large amounts of data (i.e. a high memory bandwidth) typically corresponds to high latency and power consumption of the ray tracing system.granulocyte and macrophage infiltration and inflammation^[@CR11]^. Due to cell death induced by *P. multocida*, the nuclear protein HMGB1 was transferred to the extracellular space, triggering an inflammatory response in the form of increased IL-6^[@CR34]^. LPS from *P. multocida* stimulated activation of the nuclear factor kappa-light chain enhancer of the TLR4-mediated activated B cell (NF-κB) pathway, producing IL-6^[@CR35]^.

When these proinflammatory cytokines were released and bound to receptors, the mitogen-activated protein kinase (MAPK) signaling pathway and NF-κB promoted the expression of cytokines and chemokines, thereby further activating immune responses and inflammation^[@CR36]^. Inflammatory cells concentrated at the site of injury are stimulated by inflammatory factors and continued to release many proinflammatory factors, such as HMGB1 and IL-6, leading to cell death and potentiating inflammatory responses^[@CR37],[@CR38]^. Thus, bacterial-induced cytokine secretion further mediated


1 min, the supernatant fluid was discard. The preciptates were repeatedly washed with sterile 0.9% saline for 3 times to prepare bacteria samples. Bacterial DNA was purified by a EasyPure Genomic DNA Kit (TransGen Biotech, Beijing), and used as a PCR template. In order to amplify 16S rRNA and KMT1 genes, the two pairs of primers were used (Table [1](#Tab1){ref-type="table"})^[@CR42]^. Other components of 25 uL PCR system includes 12 uL 2×EasyTaq^®^ PCR Super Mix (TransGen Biotech, Beijing), 1uL forward primer, 1uL reverse primer, 8 uL double-distilled water and 3 uL bacterial DNA template. Amplification was performed using an Applied Biosystems VeritiTM Thermal Cycler (Thermo Fischer Scientific, Waltham, MA, USA) with the following PCR conditions: initial denaturation at 94 °C for 3 min, 30 cycles of 94 °C for 30 s, 60 °C for 30 s, andQ:

Is there a way to make C macros keyword agnostic?

Is there a way to concatenate keywords in a macro and get
C to behave in a more dynamic fashion as in:
#define macro(fun,ction,var,iable) function(variable)

I know this kind of thing exists in other languages.

A:

You can use ## to concatinate names in macros
fun##ction ...


perfect Windows as much as possible before declaring it ready to RTM. The company can RTM Windows and then push patches, fixes and updates to it right up to the time it is generally available -- and continue on a regular basis after that. Supposedly, according to my sources, there will be at least one big batch of updates for Windows 8.1 and the Microsoft-built and bundled apps (like Mail, Xbox Music, the Bing apps, etc.) pushed out shortly before general availability.

Because of OEM requirements, Microsoft still needs to get PC makers the RTM bits a couple of months before they are expected to deliver new devices with those bits preinstalled. That's why Microsoft is RTMing Windows 8.1 in late August; that will give OEMs a couple monthsneed, “Hey I am in a meeting with a client right now.” I don’t know what the hell is going on with this wonderful piece of code you wrote.” Then I actually needed him to be synchronously interrupted. So I think we just need some new ways as we move to chat or identify what’s wrong with email? How do we identify new ways of handling asynchronous communication that may be different in nature and in content? And what’s happening real time in a chat room?

Matt: Yeah and I think what you’re suggesting is, we need to maybe start thinking about standardized way. I mean I had the same problems I can probably reach out to anyone of you right now via Slack, via Facebook, via text, via


getting messages from integrated tools. This is another thing that ChatOps is talking about. I can talk about my commits or my failed bills or whatever it is and I can see it right in my chat room. The problem I keep having with it though and I’m sure you guys have different problems and different problems that it also helps you solve. The problem I keep having with it is that it’s incredibly noisy and I want to be in the room where everybody shares excellent gifts of whatever memes came out this week. I do want to see that but then, presenting to a client and my chat just keeps popping up with messages that I don’t even want to…

Male Participant: …Let me ask you this.from marketing, from sea level and even support because they prefer email. I think mostly because that’s the way that they communicate externally with the customers. Which I totally get and that’s not something that’s going to change anytime soon. What I can say that has worked for us internally is to actually start moving their tools, not technical tools necessarily, not things like GitHub or Travis, things like that but using whatever tools that they use like Trello, like Salesforce. Making it so that…for example there’s information within our Salesforce system that I need to reference occasionally. The ChatOps book for example, when someone downloads that I’m curious to see how many times has this been downloaded this week. I don’t have to go look for that


here, and that was the right thing. Disney Chief Executive Bob Iger

The Burbank-based entertainment giant has a reputation for placing a premium on diversity, in its workforce as well as on the shows and movies it makes for big and small screens. After Barr’s tweet, top leaders of ABC and its corporate parent Disney came together; Dungey and Disney / ABC Television Group President Ben Sherwood were adamant that Disney had to fire its top-rated star, according to an insider familiar with the situation but not authorized to publicly discuss it. Iger immediately agreed.

The network was praised for it swift response. “Roseanne Barr’s comments were appalling and reminiscent of a horrific time in our history when racism was not only acceptable but promoted by Hollywood,” wrote NAACP Presidentcommunication between the SPORE and the MD Anderson Multi-disciplinary Research Program in Bladder Cancer (MRP) and the Cancer Center Support (Core) Grant; (3) To monitor scientific integrity and overall compliance with all governmental and NCI regulations and requirements and to coordinate quality assurance including data quality control in conjunction with the Biostatistics and Specimen and Clinical Bioinformatics Core; (4) To provide administrative support for the Developmental Research and Career Development Programs; (5) To convene all necessary meetings, including those of the Executive Committee, Internal Scientific Advisory Committee, and External Scientific Advisory Committee; (6) To oversee expenditures and maintain budget intonation; (7) To communicate and consult frequently with the NCI Project Leader and other staff and prepare all necessary internal and external reports; (9) To establish and maintain electronic


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is a lot like The Call. The promotional material for the next Call rally, in Detroit in November, explains that the city "has become a microcosm of our national crisis—economic collapse, racial tension, the rising tide of the Islamic movement, and the shedding of innocent blood of our children in the streets and of our unborn." But The Response is a little sunnier, says Finn. It's a complement to the 24-hour, 7-days-a-week prayers going on at some of the churches that organized this event.

"They have been praying and fasting for our nation for a decade," she tells me, standing right in front of the stage where Radiant Band is singing about how there's "no God like Jehovah."

"This is the first time a governor, one of the highest-ranking officialsin Zion, declare a holy fast, call a sacred assembly.

Perry is interrupted by applause; the crowd wants to cheer the reference to Zion.

Gather the people, consecrate the assembly; bring together the elders, gather the children, those nursing at the breast. Let the bridegroom leave his room and the bride her chamber. Let the priests, who minister before the Lord, weep between the temple porch and the altar. Let them say, "Spare your people, O Lord. Do not make your inheritance an object of scorn, a byword among the nations. Why should they say among the peoples, 'Where is their God?' "

The soon-to-be Republican presidential frontrunner, who is best known among liberal voters for raising the prospect of secession and for presiding over hundreds of executions, has just presented


<?php

namespace Hejiang\Sms\Senders;

use Hejiang\Sms\Exceptions\SmsException;
use Qcloud\Sms\SmsSingleSender;

/**
 * Qcloud sender
 *
 * @property-read SmsSingleSender $sdkInstance
 */
class QcloudSender extends BaseSender implements SenderInterface
{
    private $_sdkInstance;

    public function getSdkInstance()
    {
        if ($this->_sdkInstance === null) {
            $this->_sdkInstance = new SmsSingleSender($this->accessKey, $this->secretKey);
        }
        return $this->_sdkInstance;
    }

    public function send($phoneNumber, $tplId, $tplParams, $sign = '')
    {
        $responseRaw = $this->sdkInstance->sendWithParam(
            '86',
         © koninklijke brill nv, leideN, 2019 | DOI: 10.1163/9789004400467_018 CHAPTER 18 Listening Zeyad El Nabolsy The leaders realize, not without a certain astonishment, the wealth of spirit, the capacity for reasoning and clear statement of ideas, the facility for comprehension and assimilation of concepts on the part of populations who only yesterday were forgotten if not despised and regarded by the colonizer, and even by some natives, as incompetent beings. amilcar cabral ∵ In this chapter I focus on listening as a potentially revolutionary pedagogical activity. I argue that listening should not be understood as an essentially passive state, and focus on pedagogical situations where the educator can be misled by prejudices regarding the abilities, or lack thereof, of the individuals that the pedagogue is interacting with in


their very existence (qua parasitic, unproductive Listening 257 aristocracy) depended on the preservation of that relation of exploitation. Consequently, an Egyptian peasant simply could not formulate a belief such as "I am being exploited because..." or "the landowners are exploiting my labor by doing...." This had nothing to do with any lack of conscientiousness qua epistemic agents on their part, but was simply a structural fact about the collective conceptual resources which were available to them. Here we have a case where social power was almost completely in the hands of dominant social groups (in this case grouped by class, and specifically by their relation to the surplus that is produced by the peasantry), and this near complete monopoly of social power was reflected in a near completedraw on some contemporary work in feminist epistemology to specify the characteristics that the revolutionary pedagogue should possess. Miranda Fricker defines the virtue of the hermeneutically just listener (or interlocutor) in the following terms: "an alertness or sensitivity to the possibility that the difficulty one's interlocutor is having as she tries to render something communicatively intelligible is due not to its being a nonsense or her being a fool, but rather to some sort of gap in collective hermeneutic resources [of a given society]" (Fricker, 2007, p. 169). This point is important insofar as it is necessary for the pedagogue as a listener to think of the manner in which the hegemony of the ideas of the ruling class in a given society might impede the oppressed from


traced to Paulo Freire's Pedagogy of the Oppressed (first published in 1968, then translated into English in 1970), and the debates that took place at Dar es Salaam University in the late 1960s and early 1970s about how to recast and adapt historical materialism to the situation in Tanzania (Park & Kinsey, 1991).8 PAR has been used to help rural women in countries like Tanzania, and India develop their own political and social movements. Both radical pedagogues and the adherents of PAR subscribe to the claim that "Education ought to enable whomever acquires it to fight against oppression" (Mbilinyi, 2010, p. 89) and that "the job of teachers is revolution" (Mbilinyi, 2010, p. 90). PAR's methodology is essentially aimed at the transformation of both the pedagogues (or thetraitors, and if they are men, gender traitors: "we must die to our class-belonging [become class traitors] and resurrect with the victims of a class-society" (MOTT, 1979, p. 29). It is worth remarking that even though the language of treason might be criticized for being rather too dramatic, it is in some respects more accurate than the language of allyship (which seems to dominate "progressive" discourse in North America). The language of treason makes it clear that a man who, for example, attempts to take a stand against a patriarchal social system is betraying his own material interests as well as the normative ideals that have shaped his very sense of selfhood. He is rebelling against the destiny which was assigned to him to by society (i.e., to


2 I think that this is a more precise and accurate formulation of what Paulo Freire is trying to capture with the idea that the oppressed internalize their oppressors (Freire, 1983, p. 166). 3 Though there was certainly a conception of justice or Ma'at (Jeffers, 2013). Nonetheless, the concept of economic exploitation has greater specificity than the concept 268 El Nabolsy of injustice, so one should not infer from this fact that there was an adequate substitute for the concept of exploitation. 4 Although we should not think that resistance to slavery was ever absent. However, there is a significant difference between resistance to slavery and full-blown slave rebellions. 5 It is important to qualify the lack of education as a lack of "formal" education, rather than athe endless tributes from the political and media classes in recent days. The ghoulish display at the McCain funeral would have to be just about the biggest act of revisionism in world history. It is a symbol of the US sinking into the mire, its soul well and truly lost. McCain has been transformed from Hyde to Jekyll, from beast to beauty in an extraordinary display of the most misplaced and repugnant admiration imaginable. His warmongering slate was wiped clean, replaced by the anointing of McCain as the new Mother Theresa, a human rights champion and world leader in disseminating the ideals of democracy and freedom. The rivers of blood and tears he did more than nearly anyone to create were washed away from public consciousness by gushing


of 2012. Undeterred by a Libya fast spiraling out of control —another bloody foray pushed by McCain—the deadly duo pushed Barack Obama to actively arm terrorist groups. Exploiting false sympathy which has seen him inexplicably eulogized as a human rights champion, McCain said the US couldn’t just sit and watch the opposition being decimated by Assad forces. Obama for his part believed the fall of Assad was inevitable, a matter of when not if. It wasn’t long however before Obama joined the McCain driven jihadist express and commenced Operation Timber Sycamore. If Obama was wary of the Libya disaster, it didn’t stop him warming to the idea of sending arms from the country into Syria, a program actively pushed by Hillary Clinton.

“I believe there are ways to get“Award for Courage and Leadership.” Vanessa Beeley, in an article for 21st Century Wire said, “Raed Saleh (White Helmets leader) was in Arizona, April 20-22, to receive the award at the by-invitation-only Sedona Forum. By Saleh’s side was Syria Campaign’s Kenan Rahmani acting as translator and PR agent. Coming almost immediately after the heaping of praise upon the group by Nauert, the McCain stamp of approval is further evidence of the overt ties between the U.S state and their most useful intelligence operatives on the ground in Syria.”

Moreover, the White Helmets had recently signed contracts with Turkish and Qatari organizations to carry out new projects, one assumes inside Syria. These projects are still to be announced by Raed Saleh.

Were these projects established or supported by the McCain Institute


the up-regulation of EDEM1 transcripts.

Interestingly, Tu increased the EDEM1 mRNA amount in HepG2 cells to a level similar to that found in HepG2.2.2.15 cells, in the absence of any treatment, while having no consequences on the steady-state level of EDEM1 mRNA in HepG2.2.2.15 cells. This suggests that unlike HepG2, the HepG2.2.2.15 cells are already exposed to a significant amount of chronic ER stress, due to the high rate of HBV replication, to which they have adapted by eliciting a sufficient level of UPR [@pone.0034169-Li1].

To determine the relationship between HBV and EDEM1 expression in cells hosting a progressive HBV replication, the EDEM1 transcripts were quantified in Huh7 cells transfected with pTriex HBV 1.1. The plasmid contains 1.1 units of the whole HBV genome and is able to support viralused a total protein, gel loading control.](pone.0034169.g002){#pone-0034169-g002}

![HBV envelope proteins are degraded in the presence of EDEM1, in a dose dependent manner.\
(A) HEK293T cells were transfected with pCiS in the presence or absence of pCMVEDEM1. Cell lysates were split in two and equal amounts of proteins were subjected to SDS-PAGE under reducing conditions, followed by Western blotting with anti-EDEM (upper panel) or anti-S (lower panel) Abs. Controls, mock-transfected cells were also included. Calnexin (Cnx) expression was used a total protein, gel loading control. (B) The relative band intensities were quantified and compared to control (considered 100%), using the "Quantity One" software from BioRad.](pone.0034169.g003){#pone-0034169-g003}

The inverse relationship between EDEM1 expression and HBV may appear to contrast the results in [Fig. 1E](#pone-0034169-g001){ref-type="fig"} showing increased expression of both EDEM1 and HBV antigens during


This effect was not due to the over-expression of the viral proteins in a heterologous system, as similar degradation rates were observed in cells allowing for both, high and moderate level of viral protein synthesis (HEK293T and HepG2.2.2.15, respectively). The envelope proteins rescued from degradation in endogenous EDEM1-knock down cells were able to assemble in functional, secretion-competent subviral particles, implying that they do not originate from a pool of terminally misfolded polypeptides. Moreover, these proteins are actively recruited for nucleocapsid envelopment, which suggest that virion and SVPs assembly may be competing processes, despite the envelope proteins being synthesised in vast excess.

Interestingly, it was recently found that up-regulation of EDEM1, a condition occurring during UPR, bypasses the requirement for mannose trimming of glycoprotein ERAD substrates. Consequently, the folding qualitymyopathy [@pone.0034169-Fujita1]. Usually, wild-type and mutant dysferlin are degraded by the ubiquitin/proteasome system - ERAD (I); however, when this degradation is not sufficient, the proteins aggregate on the ER membrane and stimulate autophagy formation. Thus, the autophagy/lysosome degradation - ERAD (II) may function as an alternative pathway when the retrotranslocon/ERAD (I) system is impaired by the accumulation of protein aggregates within the ER.

In the case of HBV, correctly folded envelope polypeptides become highly cross-linked by disulfide-bonds within the ER, before assembly into virions and SVPs. Therefore, it is possible that the unstable polypeptides, prematurely extracted from the quality control cycle when EDEM1 is up-regulated, are forced into aberrant intra- and inter-molecular disulfide bond pairing and further aggregation.

Although the exact mechanism of the HBV wild-type envelope protein degradation is


Primers were designed to amplify either HBV- or EDEM1-3- specific fragments ([Table S1](#pone.0034169.s002){ref-type="supplementary-material"}). For viral quantification, a calibration curve containing known amounts of HBV was used. The values obtained were standardized against an internal β-actin control. Where indicated in the figure legends cells were also treated with either 10 µM 3TC or 5 µg/ml tunicamycin.

Pulse-labeling and immunoprecipitation {#s4i}
--------------------------------------

Subconfluent HepG2 and HepG2.2.2.15 cells grown in six-well plates were were labelled as described before (as described [@pone.0034169-BranzaNichita1]. Briefly, the monolayers were washed once with PBS and incubated in methionine- and cysteine-free RPMI 1640 medium (ICN Flow). After 1 h, the cells were pulse-labeled with 100 µCi of ^35^Smethionine-^35^Scysteine (Tran ^35^S-label, 1,100 Ci/mmol; ICN Flow) per ml at 37°C for the times indicated. The cells were lysed under mild conditions usingrepresents an oxygen or a sulfur atom;
m is zero or an integer from 1 to 4;
n is an integer from 1 to 4;
p is an integer from 1 to 4;
or a pharmaceutically acceptable salt thereof.
A preferred group of compounds of formula (I) is that wherein R1a and R1b each independently represent hydrogen, C1-6aLkyl, fluoroC1-6alkoxy or halogen. Where R1a and R1b are both other than hydrogen, preferably R1a and R1b are the same. Where R1a is other than hydrogen and R1b is hydrogen, R1a is preferably attached to the indole ring at the 5-position.
A particularly preferred group of compounds of formula (I) is that wherein R1a and R1b each independently represent hydrogen, methyl, trifluoromethoxy, fluorine or chlorine.
As especially preferred group of compounds of formula (I) is that wherein R1a


the present invention may also be used in combination with a selective serotonin reuptake inhibitor (SSRI).
The present invention accordingly provides the use of a compound of formula (I) and an SSRI for the manufacture of a medicament for the treatment or prevention of obesity.
The present invention also provides a method for the treatment or prevention of obesity, which method comprises administration to a patient in need of such treatment an amount of a compound of formula (I) and an amount of an SSRI, such that together they give effective relief
In a further aspect of the present invention, there is provided a pharmaceutical composition for the treatment or prevention of obesity comprising a compound of formula (I) and an SSRI, together with at least one pharmaceutically acceptable carrier orgive the title compound as a pale brown solid (20 mg), consistent with a resin loading of 0.52 mmol/g prior to activation and cleavage.
5-Methyl-xcex1-oxo-2-phenyl-1H-indole-3-acetyl chloride (Ind. J. Chem. Sec. B. 1995, 796-801; 2.5 g, 12 mmol) was added to a solution of triethylamine (25 mL) in ethanol (150 mL). The solvent was evaporated under reduced pressure, water was added and the mixture was extracted with ethyl acetate. The combined organic fractions were dried (MgSO4) and the solvent was evaporated under reduced pressure to give the title compound as a pale brown solid (3.8 g, 98%). 1H NMR (250 MHz, CDCl3) xcex41.03 (3H, t, J 7 Hz), 2.53 (3H, s), 3.60-3.84 (2H, m), 7.18-7.20 (1H, m), 7.30-7.35 (2H, m), 7.40-7.57 (5H, m), and 8.23 (1H, s).
A suspension of palladium


under reduced pressure. The residue was recrystallized from ether to give the title compound as a colourless solid (1.1 g, 76%). 1H NMR (360 MHz, CDCl3) xcex42.47 (3H, s), 3.85 (3H, s), 7.05 (1H, dd, J 8.3, 1.4 Hz), 7.27 (1H, d, J 11.2 Hz), 7.36-7.49 (4H, m), 7.62 (1H, d, J 9.2 Hz), and 8.05 (1H, br s). m/z (ES+) 266 (M+1).
Triethylamine (1.4 mL, 10 mmol) was added to a stirred suspension of xcex4-oxobenzenepentanoic acid (1.92 g, 10 mmol) and (4-methylphenyl)hydrazine hydrochloride (1.59 g, 10 mmol) in ethanol (16 mL) and the mixture was stirred at room temperature for 4 h. Ether (100 mL) was added, the mixture was filtered and the solvent was evaporated under reduced pressure. The residue was added slowly to trifluoroacetic acid (1524) and-(2-methoxyphenyl)piperazine hydrochloride according to the method of Description 25. 1H NMR (360 MHz, CDCl3) xcex47.89 (1H, br s), 7.40 (1H, s), 7.24 (1H, d, J 8.3 Hz), 7.04-7.00 (3H, m), 6.94-6.81 (3H, m), 3.86 (3H, s), 3.81 (2H, t, J 5.0 Hz), 3.53 (2H, t, J 5.0 Hz), 3.13 (2H, t, J 7.6 Hz), 2.96 (2H, t, J 5.0 Hz), 2.80 (2H, t, J 5.0 Hz), 2.77-2.73 (2H, m), and 2.46 (3H, s).
A solution of bromotrimethylsilane (0.27 mL, 2.62 mmol) in dimethylsulfoxide (5 mL) was added dropwise to a solution of 1-[3-(1-indol-3-yl)-1-oxopropyl]-4-(2-methoxyphenyl)piperazine (Description 25, 0.5 g, 1.38 mmol) in dimethylsulfoxide (10 mL) and the mixture was stirred at room temperature for 2 h. The mixture was poured into saturated aqueous sodium hydrogen carbonate and extracted with ethyl


m), 6.66, 6.40 (total 1H, each br s), 5.01, 4.80 (total 1H, each m), 4.24-3.82 (2H, m), 3.75 (3H, s), 3.39 (1H, m), 2.94 (1H, m), 2.81, 2.76 (total 3H, each s), and 1.37, 1.27 (total 9H, each s). m/z (ES+) 351 (M+1).
Trifluoroacetic acid (5 mL) was added to a solution of (S)-N-(2-{N-[(1,1-dimethylethoxy)carbonyl]methylamino}-1-oxo-3-phenylpropyl)glycine methyl ester (Description 32, 2.28 g, 6.5 mmol) in dichloromethane (50 mL) and the mixture was stirred at room temperature for 3.5 h. The solvent was evaporated under reduced pressure, then toluene was added and evaporated under reduced pressure. Aqueous sodium carbonate (10%, 100 mL) was added and the mixture was extracted with dichloromethane (2xc3x97100 mL). The combined organic fractions were dried (MgSO4) and the solvent was evaporated under reduced pressure. The residue was purifiedtime reading about which direction to shave your facial hair or watching cricket. That left the way free for us to leave a trail of destruction and broken hearts up and down the country.

Did you listen to Oasis' later albums after leaving the group? If so, what is your opinion of them?

Yeah of course I listen closely. Can’t say I’ve actually bought one though. The first albums were fantastic but I kind of lost interest after that until ‘Dig Out Your Soul. Some of the in between bits were almost predictable but that may be because I was very familiar with Noel and the way he wrote.

Do you think your book will encourage other former members of the band to release one?

I hope so. I would most look


which is within the range of about 200,000 to about 1,000,000 and (II) a low molecular weight styrene-butadiene rubber having a number average molecular weight which is within the range of about 20,000 to about 150,000; wherein the ratio of the high molecular weight styrene-butadiene rubber to the low molecular weight styrene-butadiene rubber is within the range of about 80:20 to about 25:75; wherein the bound styrene content of the high molecular weight styrene-butadiene rubber differs from the bound styrene content of the low molecular weight styrene-butadiene rubber by at least 5 percentage points; wherein the styrene-butadiene rubber composition is made by coagulating a blend of a latex of the high molecular weight styrene-butadiene rubber and a latex of the low molecular weight styrene-butadiene rubber; and wherein thelatex of the high molecular weight styrene-butadiene rubber and the low molecular weight styrene-butadiene rubber are made by a process which comprises (1) charging water, a soap system, a free radical generator, 1,3-butadiene monomer and styrene monomer into a first polymerization zone; (2) allowing the 1,3-butadiene monomer and the styrene monomer to copolymerize in the first polymerization zone to a monomer conversion which is within the range of about 15 percent to about 40 percent to produce a low conversion polymerization medium; (3) charging the low conversion polymerization medium into a second polymerization zone; (4) charging an additional quantity of 1,3-butadiene monomer and an additional quantity of styrene monomer into the second polymerization zone; and (5) allowing the copolymerization to continue until a monomer conversion of at least


by adding styrene monomer, 1,3-butadiene monomer, water, a free radical generator and a soap system to a first polymerization zone to form an aqueous polymerization medium. The first polymerization zone will normally be a reactor or series of two or more reactors. Copolymerization of the monomers is initiated with the free radical generator. This copolymerization reaction results in the formation of a low conversion polymerization medium.
At the point where the low conversion polymerization medium reaches a monomer conversion which is within the range of about 15 percent to about 40 percent, the low conversion polymerization medium is charged into a second polymerization zone. The second polymerization zone can be a reactor or a series of two or more reactors. In any case, the second polymerization zone is subsequentsamples are dissolved in a solvent and then injected unfiltered into the thermal field flow fractionation system. The sample mass injected is typically about 0.12 mg.
The raw data is collected and processed in Wyatt Technologies Corporation in software program ASTRA. The data collection period is 25 minutes. Baselines for the peaks are typically set from 1.5 minutes to 25 minutes for the light scattering detectors and from 1.5 minutes to 20 minutes for the refractive index detector. For the data processing, the DAWN light scattering detectors used include 5 through 16 (representing angles from 39xc2x0 to 139xc2x0 in THF). The angular dependence of the light scattering is fit using a first order equation in the Zimm formalism. A refractive index increment (dn/dc) of 0.154 is used for all


Mooney ML 1+4 viscosity which is within the range of about 3 to about 30. The low molecular weight SBR will more preferably have a number average molecular weight which is within the range of about 55,000 to about 110,000, a weight average molecular weight which is within the range of about 120,000 to about 260,000 and a Mooney ML 1+4 viscosity which is within the range of about 5 to about 20. The low molecular weight SBR will usually have a Mooney ML 1+4 viscosity which is within the range of 10-18.
The low molecular weight SBR will have a Mooney ML 1+4 viscosity that differs from the Mooney ML 1+4 viscosity of the high molecular weight SBR by at least 50 Mooney points. The high molecular weightcis-1,4-polybutadiene rubber. Blends of 40 phr to 60 phr of the SBR with 40 phr to 60 phr of natural rubber and/or cis-1,4-polybutadiene rubber are most typical. The cis-1,4-polybutadiene rubber employed in such blends will typically have a cis-1,4-isomer content of at least about 90 percent and will more typically have a cis-1,4-isomer content of at least about 95 percent. High cis-1,4-polybutadiene rubber which is suitable for use in such blends typically has a cis-isomer content of greater than 90 percent and can be made by the process described in Canadian Patent 1,236,648. High cis-1,4-polybutadiene rubber which is suitable for employment in such blends is also sold by The Goodyear Tire and Rubber Company as Budene(copyright) 1207 polybutadiene rubber and Budene(copyright) 1208 polybutadiene rubber.
Tire tread compounds having extremely


such a blend to contain (1) from about 30 to about 50 parts of natural rubber, (2) from about 10 to about 20 parts of high cis-1,4-polybutadiene rubber, (3) from about 20 to about 40 parts of the SBR composition and (4) from about 10 to about 20 parts of the 3,4-polyisoprene rubber. It is more preferred for such a tire tread rubber formulation to contain (1) from about 35 to about 45 parts of natural rubber, (2) from about 10 to about 20 parts of high cis-1,4-polybutadiene rubber, (3) from about 25 to about 35 parts of the SBR composition and (4) from about 10 to about 20 parts of the 3,4-polyisoprene rubber.
In order to maximize tire performance characteristics, a combination of high Tg 3,4-polyisoprene, low Tg3,4-polyisoprene and the SBR composition of this invention can be employed in the tire tread compound. The low Tg 3,4-polyisoprene will have a Tg of less than about xe2x88x925xc2x0 C. The low Tg 3,4-polyisoprene will typically have a Tg which is within the range of about xe2x88x9255xc2x0 C. to about xe2x88x925xc2x0 C. It is preferred for the low Tg 3,4-polyisoprene to have a Tg which is within the range of about xe2x88x9230xc2x0 C. to about xe2x88x9210xc2x0 C. and it is most preferred for the low Tg 3,4-polyisoprene to have a Tg which is within the range of about xe2x88x9220xc2x0 C. to about xe2x88x9210xc2x0 C. The low Tg 3,4-polyisoprene will also typically have a number average molecular weight of greater than about 200,000. The low Tg 3,4-polyisoprene will generally


the silica should be subjected to a thermomechanical mixing step. The thermomechanical mixing step generally comprises a mechanical working in a mixer or extruder for a period of time suitable in order to produce a rubber temperature between 140xc2x0 C. and 190xc2x0 C. The appropriate duration of the thermomechanical working varies as a function of the operating conditions and the volume and nature of the components. For example, the thermomechanical working may be for a duration of time which is within the range of about 2 minutes to about 20 minutes. It will normally be preferred for the rubber to reach a temperature which is within the range of about 145xc2x0 C. to about 180xc2x0 C. and to be maintained at said temperature for a period of timeimmersion experience.

~~~
davis
Or just watch it on anything you can. I honestly don't think you can ruin this
film in anyway. I used to watch it on my iPod Touch.

~~~
walrus01
Better than nothing... But in its own way it really needs a high def, surround
sound experience to become fully absorbed, and your full undivided attention.
Same way if I recommend that someone watch 2001 for the first time or
Apocalypse Now Redux (the full 3 hour cut).

~~~
lhl
As an aside, for those in Los Angeles, American Cinematheque has been showing
a nearly pristine new 70mm (roadshow version) print of 2001 at the Egyptian
this month (I saw it a few weeks ago). There are screenings on the 26th and
27th.

Also, on the 30th they are screening Lawrence of Arabia in 70mm as well.
Lawrence of Arabia was filmed


Best
performance of Clive Owens career, he's wasted in everything else. The rapport
between himself and Caine is marvellous. Ejiofor is subtly menacing, more
desperation than outright evil.

Even the smaller roles are well cast and executed. Charlie Hunnam is almost
unrecognisable as the dreadlocked villain Patric. Peter Mullan does a
fantastic turn as the brutal Syd.

The writing took the source material and squeezed far more emotion and drama
out of it than was in there. Throwaway lines hint at so much untold story.
There's a scene where Theo goes to visit his cousin to try and get travel
documents. He has Michelangelo's David in the hallway of his office, and he
talks off-handedly about "that thing in madrid was a real blow to art" or
something. There's this whole backstory in there about the UK government
trying to salvageCircuit Court judgment he should have filed a supplemental motion and affidavit for attorney's fees and costs to that court. Mr. Hodde's affidavit does not explain what amount of his 37 claimed hours were associated with the bankruptcy proceeding, stating only that the hours resulted from his efforts "to enforce support or contempt Orders against the Debtor." Therefore, the issue of attorney's fees and costs to be awarded Mr. Hodde for work after August 5, 1983, is remanded to the bankruptcy court for a determination of the number of hours Mr. Hodde expended working specifically on this nondischargeability proceeding and for the award of reasonable attorney's fees for that work and that work alone.

Conclusion
Accordingly, the bankruptcy court's decision granting the plaintiff's motion for summary judgment and awarding $8,914.65


who helped expose drug companies' manipulation of clinical trial data.

GSK said it will "publish CSRs [clinical study reports] for all of its medicines once they have been approved or discontinued from development and the results have been published". It will eventually lead to the publication of all trial data dating back to the formation of the company in 2000 when Glaxo Wellcome merged with SmithKline Beecham.

Patrick Vallance, GSK's president of pharmaceutical research and development, said: "We are committed to being transparent with our clinical trial data to help advance scientific understanding and inform medical judgment. All those involved in the conduct and publication of clinical research, whether healthcare companies like GSK, academia or research organisations, have a role to play in ensuring that the data they generate are& Barker Car Co. v. Przezdziankowski (1908), 170 Ind. 1, 15, 83 N.E. 626; Jones v. Cary (1941), 219 Ind. 268, 37 N.E.2d 944; 5 Am. Jur. 875, § 669; 65 C.J.S., Negligence, § 265.
In passing upon a motion for a directed verdict in a negligence action, the court is merely called upon to determine if there is some evidence of negligence on the part of the defendant which the jury is entitled to consider in deciding that issue, or if the undisputed evidence discloses that plaintiff was guilty of negligence that proximately contributed to his injury or death. Baltimore & Ohio R. Co. v. Reyher, Admx., supra.
On appeal, when the sufficiency of the evidence is questioned, we do not weigh the evidence, but we examine the record


not appear at the church for the services, and after the church services were over the decedent's two sons searched for him in Haysville and about the church properties twice. Finally, about 9:00 p.m., the two sons found the body in the open ditch by the concrete culvert along State Road 56. The decedent's head and face were against the culvert head, stomach down, and the rest of the body was stretched out in the ditch. There was blood all over the decedent, on the ground and on the culvert. His skull was fractured, which had caused his death. There was a burn-like scar about the size of a hand on his right hip, and a bruise between the knee and ankle of his right leg. The decedent'sparts of said instruction clearly were erroneous, justifying its refusal by the trial court.
It is settled in this state that when the trial court gives a specific instruction as to what the plaintiff *510 must prove to be entitled to recover (as the court's instructions 9 and 10 did in this case, so far as the negligence charged was concerned), it is not error to refuse instructions tendered by the defendant to the effect that there was no burden on him to prove himself not guilty of such negligence. Terre Haute, etc., Traction Co. v. Hayes (1924), 195 Ind. 638, 645-646, 145 N.E. 569.
Appellant's tendered instructions 4 and 5 were refused by the court.
Appellant considers his tendered instructions 4 and 5 as companion instructions and states that both


appellant's theory of circumstantial evidence.
A careful study of the two instructions, this instruction and the court's own instruction 11, will disclose that there is no substantial difference between the two. Both admonished the jury to use caution and vigilance in considering such evidence, but the instruction of the court went even farther and advised that such evidence required "careful and patient consideration and analysis." Both told the jury that the mere coincidence of a number of circumstances was not sufficient unless the circumstances were so conclusive as to exclude every other hypothesis. Both told the jury that if the circumstances only concurred with or rendered probable a certain hypothesis, such fact would not be established by a fair preponderance of the evidence.
Much of the language and phraseology ofnew trial relied upon, there shall be concisely stated the basis of the *519 objection to the ruling complained of, exhibiting clearly the points of fact and of law being presented and how they are applicable...." No effort has been made to comply with the quoted part of the Rule.
As previously stated in this opinion, the trial court, in its own instruction 11, gave an erroneous charge upon the subject of circumstantial evidence, which was invited by the tender of appellant's instruction 8. Tendered instruction 10 emphasizes and aggravates the errors referred to above and goes one step further by mandatorily attempting to apply to this case the same standards that pertain to the place of circumstantial evidence in criminal cases.
There was no error in the refusal of


derivative of w**4/4 - w**3/2 - 3*w**2/2 + 2*w. Let c(s) = 2*j(s) - 3*l(s). Calculate c(f(q)).
-3*q**2
Let k(s) = s**2. Let r = 1 - -2. Let w(g) = 66*g + r*g**2 - 66*g. What is w(k(a))?
3*a**4
Let w(l) = -l. Let x(k) = 753*k. Give x(w(m)).
-753*m
Let r(c) = -2*c + c + 0*c. Let k(t) = t**2 + t + 1. Let i(a) = -6*a**2 - 5*a - 5. Let u(f) = i(f) + 5*k(f). Determine u(r(l)).
-l**2
Let j(c) = 44*c - 21*c - 22*c. Let d(b) = 18*b. Calculate d(j(o)).
18*o
Let c(p) = -p. Let o(b) = b. Let w be 1 + -2 + (-2 - -1). Let r(g) = g**2 - 3*g. Let a(t) = w*r(t) - 6*o(t). What is a(c(q))?
-2*q**2
Let n(d) be the third derivative ofthe first derivative of 1 + h*d**2 + 0*d. Let f(t) = 2*t**2. What is f(j(c))?
18*c**2
Let k(o) = o**2. Let j be (-12)/(-9)*(2 + 1). Suppose -1 - 1 = -c. Let v(g) = -c*g + 4*g - j*g. Calculate v(k(w)).
-2*w**2
Let q be (7 + -6)/(1/11). Let u(m) = -7*m**2 - m**2 + q*m**2. Let k(i) be the first derivative of i**2/2 + 2. What is k(u(d))?
3*d**2
Let z(x) = x**2 - 5*x**2 - x**2. Let d(f) = 3*f - f**2 - 4*f + f. What is z(d(a))?
-5*a**4
Let n(u) = 2*u. Let g(t) = -20*t**2 + 52*t. What is g(n(r))?
-80*r**2 + 104*r
Let i(n) = -10*n**2. Let p(b) = -5*b**2 + 6*b. Let t(v) = 4*v**2 - 5*v. Let w(c) = -5*p(c) - 6*t(c). Calculate i(w(u)).
-10*u**4
Let u(q) = 40*q**2. Let


recreate my solution from 2012. @MarcB pointed me towards UNIX sockets. This page explicitly mentions fsockopen, which opens a socket as a file pointer. It also includes in the "See Also" section a link to socket_connect, which gives you a bit lower-level control over sockets.
At the time I likely spent a long time researching these socket_* functions until I got something working. Now I did a quick google search for socket_create_pair and found this helpful link to get you started
I've rewritten the code above writing the results to UNIX sockets, and reading the results into the parent thread:
<?php
/*
 * I retained the same public API as my original StackOverflow question,
 * but instead of performing actual searches I simply return static data
 */

class multithreaded_search {
   that abstracts pthreads
If you don't like digging through the weeds and just want simple multiprocessing without having to worry about the implementation details, looks into a library like Amp/Parallel

A:

forked children will gain their own dedicated copy of their memory space as soon as they write anywhere to it - this is "copy-on-write". While shmop does provide access to a common memory location, the actual PHP variables and whatnot defined in the script are NOT shared between the children.
Doing $x = 7; in one child will not make the $x in the other children also become 7. Each child will have its own dedicated $x that is completely independent of everyone else's copy.


Recovery of polyphenols onto porous carbons developed from exhausted grape pomace: A sustainable approach for the treatment of wine wastewaters.
Removal of total polyphenols (TPP) is not only necessary as a pretreatment stepfor anaerobic digestion of wine wastewaters (WWW) but also the recovered polyphenols can be used as a dietary supplement. With a view to make the process sustainable, eco-efficient and cost effective, exhausted grape pomace (EGP) after the extraction of polyphenols was impregnated with ZnCl2 (1:1.5) and further activated at 450 °C for 1 h under inert atmosphere. The GPAC (grape pomace activated carbon) thus developed exhibited well-developed porosity with a predominance of micropores, high surface area and selective surface binding sites. Batch adsorption conducted on diluted WWW revealed the better performance of GPAC (84.3% removal) as comparedGDPR Compliance

What is NonStop doing about GDPR?

As a business we are committed to continuous improvement, ensuring we hold ourselves to appropriate standards and provide a high level of service to candidates and clients.

We store candidate (job seeker) information in order to help people find new jobs and use that information to match them with suitable roles or employers. Should we find a good match, we will share that information with the potential employer and occasionally other third party suppliers such as payroll or umbrella companies.

As a client, you can expect that we store your professional, and sometimes personal data – your mobile number, for example, if you have given this to us – in order to ensure we find the right potential employees for you. Though the GDPR


of serum and urine, markers of different metabolites, and to study the effect of DTG and TLR on DN by analyzing the regulation of different metabolites. Moreover, the high glucose-induced GMCs model *in vitro* evaluate the efficacy of DTG and TLR on DN by determination of TGF-β1, Wnt4 and β-catenin proteins expression levels.

Materials and Methods {#s1}
=====================

Chemicals and Instruments
-------------------------

UPLC-grade acetonitrile was purchased from Merck (Darmstadt, Germany), formic acid and STZ were purchased from Sigma-Aldrich (Sigma, St. Louis, MO, United States). HPLC-grade acteoside was purchased from the National Institutes for Food and Drug Control (Beijing, China) and the purity is above 98%. BUN reagent kit, LDL reagent kit, T-CHO reagent kit, TG reagent kit, Scr reagent kit, UP reagent kit, serum β2-microglobulin (β2-MG) reagent kit were bought from Nanjing JianchengMeidakang Pharmaceutical Co., Ltd., the main component is acteoside, and the content of the acteoside in the DTG was 13.61%. The MRM chromatogram and structure of catalpol, ajugol and acteoside were presented in **Figure [1](#F1){ref-type="fig"}**. Moreover, we made the content of acteoside in TLR oral solution and DTG oral solution is consistent for rats.

![MRM chromatogram and structure of catalpol, ajugol, and acteoside.](fphar-09-01012-g001){#F1}

Experimental Animals
--------------------

All experiments were conducted with male Sprague--Dawley (SD) rats weighing 200--240 g purchased from Experimental animal center of Zhejiang Province (Zhejiang, China; Certificate no. SCXK 2014-0001). Animals were housed in cages with a constant humidity (ca. 60% ± 2%) and temperature (ca. 23 ± 2°C) and with a light/dark cycle of 12 h. The animals were underwent an adaptation period of 7 days, during which they


were allowed unlimited access to chow and tap water.

After the 7-day acclimation period, animals were randomly divided into eight groups with 6 in each group: control group (normal saline, C), model group (normal saline, M), Huangkui capsule group (0.75 g/kg⋅d, HK), Irbesartan group (27 mg/kg⋅d, YX), TLR low dose group (4.3 g/kg⋅d, DHYL), TLR high dose group (7.2 g/kg⋅d, DHYH), DTG low dose group (216 mg/kg⋅d, JNL), DTG high dose group (360 mg/kg⋅d, JNH). Expect for control group rats, the rats in other groups were fed with high-fat diet (59% basic mice feed, 20% sugar, 18% lard, and 3% egg yolk) and 5% glucose water for 21 days, then, the rats were injected intraperitoneally with STZ (45 mg/kg) dissolved in 0.1 mol/L sodium citrate buffer (pH 4.5) tocells as an indicator of GMCs hypertrophy. Moreover, these cells were prepared for the western blotting to examine the expression levels of TGF-β1, Wnt4 and β-catenin protein.

Sample Preparation and UPLC-QTOF/MS Analysis
--------------------------------------------

All serum and urine samples were thawed at room temperature before preparation. The 300 μL acetonitrile was added to 100 μL serum samples to precipitated protein, and vigorously mixed for 60 s. The 100 μL acetonitrile was added to 100 μL urine samples to remove proteins and vigorously mixed for 30 s. All the samples were centrifuged at 13,000 rpm for 10 min at 4°C. Finally, the supernatant was injected to UPLC-QTOF/MS analysis.

Metabolites separation was performed using a Waters Acquity^TM^ Ultra Performance LC system (Waters, United States) equipped with a Waters Xevo^TM^ G2 Q/TOF-MS (Waters MS Technologies, Manchester,


ceramide (d18:1/12:0) (*r* \> 0.65); and negatively correlated with sphingosine 1-phosphate and phytosphingosine (*r* \< -0.65). Ceramide (d18:1/12:0), phytosphingosine and sphingosine 1-phosphate have been found and used to explain the sphingolipid metabolism. Therefore, BUN, UP, Scr, β2-MG closely related to sphingolipid metabolism.

![Correlation heat-map between biochemical indicators and potential biomarkers.](fphar-09-01012-g010){#F10}

Discussion
==========

The local and traditional uses of "Dihuang" are nourishing yin and tonifying kidney. The pharmacological studies stated that "Dihuang" possesses the significant effects on cardiovascular diseases, neuroprotection, diabetes and its complications, osteoporosis, and hyperlipidemia. Moreover, acteoside, as the main active component, was reportedly possesses widely pharmacological activities, such as kidney protection, anti-oxidation, neuroprotection, liver protection, anti-cancer, and so on. But the action mechanisms still unclear completely. In our this study, the results *in vivo* showed that TLR and DTG canto the treatment of atherosclerosis, insulin resistance, diabetes and cardiomyopathy ([@B12]). In DN, the content of ceramide increased significantly compared to normal rats and recovered to normal after administration of TLG and DTG. In recent years, studies have found that sphingosine 1-phosphate (S1P) can participate in the regulation of GMC growth and differentiation process ([@B25]). Phytosphingosine is involved in diverse cell processes, including cell-cell interaction, cell proliferation, differentiation, and apoptosis. The contents of S1P and phytosphingosine decreased in DN, which was consistent with the injured of GMCs induced by DN. In addition, sphingolipid metabolic disorders may lead to cell death and are closely related to insulin-related diseases ([@B20]).

Cholic acid glucuronide has been found and used to explain the pentose and glucuronate interconversions. Cholic acid glucuronide is the glucuronidated


Q:

Limit Possible Bone Location Within Custom Object

I would like to be able to constrain the possible X,Y and Z locations of an armature bone to within the 3D space inside a specified mesh object, such as a cube or sphere (and eventually a custom shape). I want to be able to move the bone anywhere inside the object, but not past the walls of the mesh. This would allow complex limits of a bone's location to be added in such a way that would erase the need for an animator to pay attention to the range of motion of a bone chain - they would simply be unable to exceed the realistic boundaries of the bone's location.
I have tried a few approaches, using a sphere as a basicg_c \quad \text{for} \ i = 1, \ldots, c.$$ Then we can choose $$\label{bchange-eqn}
t_i^\prime = \alpha_{1i}t_1 + \cdots + \alpha_{ci} t_c \quad \text{for} \ i = 1, \ldots, c.$$ as Eisenbud operators for $g_1,\ldots,g_c$. In [@Eis] there is a mistake in indexing. So we give a full proof here.

For the proof it is convenient to use matrices. Here $\alpha = (\alpha_{ij})$ is a $c\times c$ invertible matrix with coefficients in $Q$. If $ \phi = (\phi_{ij})$ be a $m \times n$ matrix with coefficients in $Q$ then we set $\phi^{tr} = (\phi_{ji})$ to be the transpose of $\phi$. Set $[{\mathbf{f} }]$ and $[{\mathbf{g} }]$ to be the column vectors $(f_1,\ldots,f_c)^{tr}$ and $(g_1,\ldots,g_c)^{tr}$ respectively. Thus in matrix terms we have $$[{\mathbf{f} }] = \alpha\cdot [{\mathbf{g} }].$$ Let $t_1, \ldots,


also give an example of a maximal [Cohen-Macaulay]{} module over a strict complete intersection such that the Hilbert function of $M$ is not monotone increasing.

Let $(A,{\mathfrak{m} })$ be a strict complete intersection ring of dimension $d \geq 1$. Let $M$ be a maximal [Cohen-Macaulay]{} $A$-module with ${\operatorname{cx}}_A M \leq 1$. Then the Hilbert function of $M$ is non-decreasing.

By 1.2 we may assume that $A$ is complete and has an infinite residue field. So $A = Q/({\mathbf{f} })$ where $(Q,{\mathfrak{n} })$ is a regular local ring with infinite residue field, ${\mathbf{f} }= f_1,\ldots,f_c \in {\mathfrak{n} }^2$ is a $Q$-regular sequence. Furthermore we may assume ${\mathbf{f} }^* = f_1^*,\ldots,f_c^*$ is a $G(Q)$-regular sequence and $G(A) = G(Q)/({\mathbf{f} }^*)$.

For $x \in {\mathfrak{n} }^i \setminus {\mathfrak{n} }^{i+1} $ we set ${\operatorname{ord}}(x) = i$. Without$\beta$ is an invertible matrix in $M_n(A)$. By \[inverse\] there exists a regular sequence ${\mathbf{g} }= g_1, \ldots,g_c$ such that

1.  $({\mathbf{g} }) = ({\mathbf{f} })$

2.  if $t_j^\prime$ are the Eisenbud operators associated to $g_j$ for $j = 1,\ldots,c$ then the action of $t_j^\prime$ on ${\operatorname{Ext}}^*_A(M,k)$ is same as that of $\xi_j$ for $j = 1,\ldots,c$.

By \[inverse\] $$[{\mathbf{g} }] = (\beta^{tr})^{-1}\cdot [{\mathbf{f} }] = (\beta^{-1})^{tr} \cdot [{\mathbf{f} }].$$ It is easy to compute the inverse of $\beta$. So we obtain $$\begin{aligned}
g_1 &= \frac{1}{\beta_1}f_1 \\
g_j &= \frac{-\beta_j}{\beta_1} f_1 + f_j \ \text{for} \ j = 2,\ldots,c.\end{aligned}$$ Recall that ${\operatorname{ord}}(f_1) \geq {\operatorname{ord}}(f_j)$ for $j = 2, \ldots,c$. Notice that if ${\operatorname{ord}}(f_1) = {\operatorname{ord}}(f_j)$ then $$\frac{-\beta_j}{\beta_1} f_1^* + f_j^* \neq 0,$$ since $f_1^*, \ldots, f_c^*$ is a $G(Q)$-regular sequence. Thus


check_access: prvs=7337e4471e=johnd@abc.co.il
Sep 17 18:45:55 smail1 postfix/smtpd[23196]: check_domain_access: abc.co.il
Sep 17 18:45:55 smail1 postfix/smtpd[23196]: check_namadr_access: name xyz.abc.co.il addr 1.2.3.4
Sep 17 18:45:55 smail1 postfix/smtpd[23196]: check_domain_access: xyz.abc.co.il
Sep 17 18:45:55 smail1 postfix/smtpd[23196]: check_namadr_access: name xyz.abc.co.il addr 1.2.3.4
Sep 17 18:45:55 smail1 postfix/smtpd[23196]: check_domain_access: xyz.abc.co.il
Sep 17 18:45:55 smail1 postfix/smtpd[23196]: dict_regexp_lookup: /etc/postfix/regexp_client: xyz.abc.co.il
Sep 17 18:45:55 smail1 postfix/smtpd[23196]: NOQUEUE: reject: RCPT from xyz.abc.co.il[1.2.3.4]: 450 4.1.7 <prvs=7337e4471e=johnd@abc.co.il>: Sender address rejected: unverified address: host mail1.abc.co.il[5.6.7.8] said: 550 Recipient address rejected: User unknown (in reply to RCPT TO command); from=<prvs=7337e4471e=johnd@abc.co.il> to=<janed@neptune.co.il> proto=ESMTP helo=<mail1.abc.co.il>
Sep 17 18:45:55 smail1 postfix/smtpd[23196]: > xyz.abc.co.il[1.2.3.4]: 450 4.1.7 <prvs=7337e4471e=johnd@abc.co.il>: Sender address rejected: unverified address: host mail1.abc.co.il[5.6.7.8] said: 550 Recipient address rejected: User unknown (in reply to RCPT TO command)
Sep 17 18:46:00 smail1 postfix/smtpd[23196]: < xyz.abc.co.il[1.2.3.4]: QUIT
Sep 17 18:46:00 smail1 postfix/smtpd[23196]: > xyz.abc.co.il[1.2.3.4]: 221 2.0.0 Bye
Sep 17 18:46:00Is p greater than 992?
False
Suppose 1905 = 46*j - 2230 + 915. Which is bigger: 23 or j?
j
Let o = 43875 - 43659. Which is smaller: 55 or o?
55
Let k = -152 - -153. Let l = -3957/3689 + 18/17. Is k >= l?
True
Let b(i) = -i**2 + i + 9. Let p = 45 + -41. Let u be b(p). Are u and -20/11 nonequal?
True
Let a be (-37 - -39)*609/(-2) + 1. Let t be (11 - a/20) + 4/(-10). Is 204/5 less than t?
True
Suppose -5*w - 27 = 18. Let b(k) = k**3 - k**2 + 3*k - 6. Let t be b(2). Suppose -x - 15*f - 8 = -16*f, t*f - 2 = x. Is w > x?
True
Let x(l) = -2*l**3 - 145*l**2 -


v**3 + 7*v**2 - 10*v - 10. Let y be x(-6). Let d = 85 - y. Is d <= h?
False
Let o(q) = 3*q**2 + 159*q - 330. Let s be o(-55). Let t be (12 - -10)/((0 + -1)*-17). Are s and t nonequal?
True
Let d = 18.15 - 18.25. Which is smaller: d or 75/8?
d
Suppose -5*t + t - 12 = 0, 2*b = -2*t - 12. Let a be b + 112/35 - (-11)/(-5). Which is greater: a or 11?
11
Let g = 302.74 - -15623.26. Is g at least as big as -1/2?
True
Let l(m) = 4*m**3 - 6*m**2. Let t(x) = -17*x**3 + 24*x**2. Let p(w) = -9*l(w) - 2*t(w). Let k be p(3). Let a be 11/2*2/(k + 1). Is a >= 11?
True
Let d be-4 + (-13 + 13)*(-2)/(-4). Let k be d/72*4 - 52/9. Which is smaller: k or -8?
-8
Suppose 3*p - 21 = -11 - 7. Which is bigger: 9/26 or p?
p
Let k(w) = 19*w**2 - 2*w + 3. Let z be k(1). Let l(f) = f**3 - 9*f**2 + 9*f + 12. Let d be (-714)/(-85) - (-3)/(30/(-4)). Let r be l(d). Is z greater than r?
False
Suppose 5*r + 6 = -r. Let h be 42/56*(-8)/r. Suppose 0 = h*d - 20 + 62. Is -6 less than d?
False
Let v = 74 + -63. Suppose v*g - 36 = 8*g. Let n be g/94 - 6/(-36)*0. Which is smaller: n or 0?
0
Suppose 0 = -88*a + 80*a + 40. Suppose -7*h + 62 = -9*h + 3*t, -10 =


16 = 3*r, -2*r = -z + 3. Which is smaller: r or v?
v
Let s be (157 - 156)/(14/4). Let m(l) = l**2 - 9*l - 10. Let a be m(10). Suppose a*t - 22 = t. Is s equal to t?
False
Let y = -0.18 + -0.82. Let m = -9.565 + 9.385. Do m and y have the same value?
False
Let t = -23673/38 - -623. Is t < -20?
False
Let i(a) = -a - 7. Let v be i(5). Suppose 0 = -93*b - 264*b - 4998. Which is smaller: v or b?
b
Let x(w) = w**3 + 24*w**2 - 67*w + 38. Let m be x(-26). Which is greater: 432 or m?
432
Suppose 4*f - 1054 = -j, -3*f + 802 = -3*j - 2*j. Let o = f+ -265. Let y = 3/284 + 403/15620. Is o < y?
True
Let y(h) = -h**3 + 5*h**2 + h + 11. Let x(n) be the first derivative of 2*n**3/3 - n**2 - 6*n + 8. Let o be x(3). Let t be y(o). Which is smaller: t or -20?
-20
Let r = 445119/196 - 2271. Which is bigger: r or 1?
1
Let s(d) = -5*d**2 + 11*d + 231. Let o be s(-9). Which is greater: o or 1/9?
1/9
Let a(c) = 107 + 112 + 5*c - 54 + 1. Let t be a(-24). Which is smaller: 139/3 or t?
t
Let u = -411/5 - -80. Let f(p) = -p**3 - 11*p**2 + 7*p + 75. Suppose -2*j - 5*y = -3, -4*j + 5*y + 0*y = 69. Let r


Malak Jân Nemati

Malak Jân Nemati (or Malek Jân Nemati) was born in 1906 in Jeyhounabad, a village in Iranian Kurdistan. Also known as Sheikh Jâni and Saint Jani, she was a charismatic figure and a mystical writer and poet in Kurdish and Persian language. She was the daughter of Hajj Nematollah and the sister of Ostad Elahi. There are few written sources about her life. Some elements can be found in the words of her brother Ostad Elahi whom she was very close to. A biography in French was published on the occasion of the centennial of her birth, including the translation of some of her poems and sayings.

Biography

Malak Jan was born into a family belonging to the mystical order the Ahl-e Haqq (literally “People of the Truth”).was also given a musical education as she learned to play the tanbur (Kurdish lute accompanying Ahl-e Haqq sacred chants) and the setar (classical Persian lute). Hajj Nematollah was particularly fond of her. In keeping with his wish, she wore a white habit and bonnet “so that people could not tell whether it was a boy or a girl”. She actually wore that outfit throughout her life.

When she was thirteen, she had to suffer the grief of losing her father. Shortly afterwards, she experienced a painful ocular condition and by the age of twenty, she was completely and permanently blinded. The loss of her eyesight, though, seems to have coincided with the awakening of a form of mystical passion that led her to progressively draw closer to her


With graduation in sight: perceptions of high- and low-aggression students of the journey to high school completion.
This study explores students' perceptions of the paths to high school graduation using an ecological framework. Specifically, it identifies the challenges, influences, and motivations differentiating students who remained in school despite being at high risk for dropping out-defined as consistently high levels of aggression-from students at low risk of high school dropout. We analyzed inductively 16 focus groups conducted in Northeast Georgia with 81 eleventh graders participating in the Healthy Teens Longitudinal Study. Eight focus groups consisted of 11th graders who consistently scored high on aggression from 6th to 10th grade on the Problem Behaviors Frequency Scales (n = 40; 56% boys; 54% Caucasian, 39% African American; 7% Hispanic), and 8 groupsscore of 1 + 6 + 5 = 12.

Example 2:

Input: cardPoints = [2,2,2], k = 2
Output: 4
Explanation: Regardless of which two cards you take, your score will always be 4.

Example 3:

Input: cardPoints = [9,7,7,9,7,7,9], k = 7
Output: 55
Explanation: You have to take all the cards. Your score is the sum of points of all cards.

Example 4:

Input: cardPoints = [1,1000,1], k = 1
Output: 1
Explanation: You cannot take the card in the middle. Your best score is 1.

Example 5:

Input: cardPoints = [1,79,80,1,1,1,200,1], k = 3
Output: 202

Constraints:

1 <= cardPoints.length <= 10^5

1 <= cardPoints[i] <= 10^4

1 <= k <= cardPoints.length

**Related Topics**:
[Array](https://leetcode.com/tag/array/), [Dynamic Programming](https://leetcode.com/tag/dynamic-programming/), [Sliding Window](https://leetcode.com/tag/sliding-window/)

## Solution 1. Sliding Window

The cards selected must exist at the left edge or right edge of the array. So we can start from "selecting


sprintf(page, "host-aware\n");
	case BLK_ZONED_HM:
		return sprintf(page, "host-managed\n");
	default:
		return sprintf(page, "none\n");
	}
}

static ssize_t queue_nomerges_show(struct request_queue *q, char *page)
{
	return queue_var_show((blk_queue_nomerges(q) << 1) |
			       blk_queue_noxmerges(q), page);
}

static ssize_t queue_nomerges_store(struct request_queue *q, const char *page,
				    size_t count)
{
	unsigned long nm;
	ssize_t ret = queue_var_store(&nm, page, count);

	if (ret < 0)
		return ret;

	spin_lock_irq(q->queue_lock);
	queue_flag_clear(QUEUE_FLAG_NOMERGES, q);
	queue_flag_clear(QUEUE_FLAG_NOXMERGES, q);
	if (nm == 2)
		queue_flag_set(QUEUE_FLAG_NOMERGES, q);
	else if (nm)
		queue_flag_set(QUEUE_FLAG_NOXMERGES, q);
	spin_unlock_irq(q->queue_lock);

	return ret;
}

static ssize_t queue_rq_affinity_show(struct request_queue *q, char *page)
{
	bool set = test_bit(QUEUE_FLAG_SAME_COMP, &q->queue_flags);
	bool force = test_bit(QUEUE_FLAG_SAME_FORCE, &q->queue_flags);

	return queue_var_show(set << force, page);
}

static ssize_t
queue_rq_affinity_store(struct request_queue *q, const char *page, size_t count)
{
	ssize_t ret = -EINVAL;
#ifdef CONFIG_SMP
	unsigned long val;

	ret = queue_var_store(&val, page, count);
	if (ret < 0)
		return ret;

	spin_lock_irq(q->queue_lock);
	if (val == 2) {
		queue_flag_set(QUEUE_FLAG_SAME_COMP, q);
		queue_flag_set(QUEUE_FLAG_SAME_FORCE, q);
	} else if (val == 1) {
		queue_flag_set(QUEUE_FLAG_SAME_COMP, q);
		queue_flag_clear(QUEUE_FLAG_SAME_FORCE, q);
	} else if (val == 0) {
		queue_flag_clear(QUEUE_FLAG_SAME_COMP, q);
		queue_flag_clear(QUEUE_FLAG_SAME_FORCE, q);
	}
	spin_unlock_irq(q->queue_lock);
#endif
	return ret;
}

static ssize_t queue_poll_delay_show(struct request_queue *q, char *page)
{
	int val;

	ifor sRGB-encoded components, respectively. Only color buffer components may be sRGB-encoded.
                    For the default framebuffer, color encoding is determined by the implementation.
                    For framebuffer objects, components are sRGB-encoded if the internal format of a color attachment is one of the color-renderable SRGB
                    formats.
                </para>
            </listitem>


LED devices, according to their illumination direction. The top-view LED devices are used in general lighting or used as a backlight source in direct backlit LED TVs, while the side-view LED devices are used as a backlight source in edge-lit displays such as LED TVs or mobile phone display panels. Either top-view or side-view LED has a light-emitting surface, for example a rectangular light-emitting surface, wherein an optical axis of the LED device is specified to be a vertical axis perpendicular to the plane of the light-emitting surface and passing through the center of the light-emitting surface. In this disclosure, for the purpose of illustration, a first horizontal direction and a second horizontal direction are specified such that the first horizontal direction is perpendicular to the second horizontalspecified for certain lighting applications, a typical solution is to use a PLCC-type LED device with a symmetrical radiation pattern together with a secondary optical lens to reshape the radiation pattern to achieve the desired asymmetrical light radiation pattern. This will inevitably lead to a significant increase in manufacturing cost. Extra space will be involved to accommodate the secondary optical lens as well, which is unfavorable to end product design for compact consumer electronics. If there is space constraint that the optical lens cannot be incorporated to reshape the light radiation pattern irradiated from PLCC-type LED devices, another solution is to fabricate an asymmetrical reflective cup of the lead frame. For example, two sides of the reflective cup structure is optically reflective so that the radiation pattern along


2018–19 Louisiana–Monroe Warhawks men's basketball team

The 2018–19 Louisiana–Monroe Warhawks men's basketball team represents the University of Louisiana at Monroe in the 2018–19 NCAA Division I men's basketball season. The Warhawks, led by ninth-year head coach Keith Richard, play their home games at Fant–Ewing Coliseum as members of the Sun Belt Conference.

Previous season
The Warhawks finished the 2017–18 season 16–16, 9–9 in Sun Belt play to finish in a tie for fifth place. They defeated Arkansas State in the first round of the Sun Belt Tournament before losing in the quarterfinals to Georgia Southern. They received an invitation to the CollegeInsider.com Tournament where they lost in the first round to Austin Peay.

Roster

Schedule and results

|-
!colspan=9 style=| Non-conference regular season

|-
!colspan=9 style=| Sun Belt Conference regular season

|-
!colspan=9 style=|Sun Belt Tournament

|-
!colspan=12 style=|CollegeInsider.com Postseason Tournament
|-

References

Category:Louisiana–MonroeBut he said he would "absolutely not" resign, and insisted the Lib Dems were still succeeding where they focused on their achievements in coalition.

"Based on the results which have come in so far, it has obviously been a mixed result, a mixed night for my party, for the Liberal Democrats and the other mainstream parties," Mr Clegg said.

"We will see what the further results today, what story they tell. But so far what I have seen is that where we can work really hard to tell our side of the story, we can win."

He added: "I certainly accept that there is a very strong anti-politics mood around, not only in our country but in many other parts of Europe as well. I think you will see that in


the Google Groups "AngularJS" group. It's the best Angular 4 grid and the best Angular 6 grid. The last step in this section is to modify the “app component” according to the project’s need, by removing the extra default content from app/app. This article illustrated how to implement a data table grid using UI-Grid in AngularJS and how to implement the required server side pagination. The Visual Studio Code editor supports Angular IntelliSense and code navigation out of the box. PREREQUISITES. The Use Case. He has been a Google Developer Expert for more than 5 years. Get CoreUI PRO for Angular Download CoreUI Free. Angular Data Grid sample using Material Design styling Features enabled: sorting, filtering, sync with browser URLs, pagination and item-per-page functionality. Version 23 is outGrid sample using out-of-box Bootstrap styling Features enabled: sorting, filtering (using both in-grid and external controls), sync with browser URLs, pagination and items-per-page functionality, optional plugin for CSV exports. It has a twelve column layout with different breakpoints depending on the size of the screen or the predefined CSS class. In Angularjs we have data grids like ng-grid, smart table, UI Grid etc. Built with Angular 7. x branch of the framework; One of the major browsers releases a version that will cause current. The project template creates an ASP. 为什么工具提示值会四舍. This screen almost looks like the previous article, Angular 2 to Angular 4 with Angular Material UI Components project's screen except Export to Excel button and Sorting up/down icons. I've tried a lot and finally went with


with the understanding that you have created an Angular Project and Angular Material version 6. Angular UI Components of ngx-bootstrap : Accordion, Alerts, Buttons, Carousel, Collapse, Datepicker, Dropdowns, Modals, Pagination, Popover, Progressbar, Rating, Sortable, Tabs, Timepicker, Tooltip and Typeahead. angular-bootstrap-md is the package from MdBootstrap for Angular. Here is a list of changes required to get everything running smoothly. So, run the below command to update the latest Angular CLI. ag-Grid is a feature-rich Angular Grid available in Free or Enterprise versions. If you are using Http service, then change it to. Angular 7 CLI: Angular CLI is the most important component to build Angular 7 application. Angular is a development platform for building mobile and. Angular Components Demos. Angular 9 simply is the latest version of theonwards of ag-grid-angular / @ag-grid-community/angular will support Angular 6+ only. excel is a very light jquery plugin to embed a spreadsheet, compatible with Excel, in your browser. There are a lot of callback function available which are used to many operation in ng. Add Product. Let me list out the tools and technologies used to develop these two applications. Below are the core features you'll use. With the help of our REST API, we will work on our MongoDB database, and perform various operations on Products collection. Next, we will install a few packages: > npm i --save angular-bootstrap-md chart. Hit the ground running with comprehensive, modern UI components that work across the web, mobile and desktop. It is designed from the ground up to make it easy


implement modal windows (dialog boxes) in Angular 7 with TypeScript. In this and next video, we'll cover how to implement Master Detail CRUD Operations in Angular 7 with. In real Angular app, the data is dynamic coming from the backend API. dotnet add package angular-ui-grid --version 3. HttpClient is an injectable service, it comes with the various powerful methods to communicate with the remote server. 専用工場で塗装後、発送する新サービス | 50 prius | ルーフスポイラー / ハッチスポイラー | bless。★色番号塗装発送50 プリウス | ルーフスポイラー / ハッチスポイラー【ブレス】プリウス 50系 リアゲートスポイラー 塗装済 （2色塗分けまで） 1f7：シルバーメタリック. Angular Project Set up with Bootstrap 4 and Font Awesome. Its responsive user interface adapts automatically to any device and provides the best user experience to interact with the component. can be used to provide search results from local or remote data sources.the structure of HTML, it is not convenient that the layout settings are written in an external CSS file. AngularJS History. Angular 9 simply is the latest version of the Angular framework and simply an update to Angular 2. In angularjs by using ui grid we can show data in grid format and we can implement all core features like column sorting, filtering, pagination, exporting based on our requirement easily. Plugin architecture to add custom features and hooks. It is designed from the ground up to make it easy to build UI components that fetch data with GraphQL. We also installed Angular CLI 7. With the help of our REST API, we will work on our MongoDB database, and perform various operations on Products collection. For web, mobile


an open source Bootstrap 4 & Angular based admin template. Pagination on scroll. It's the best Angular 4 grid and the best Angular 6 grid. ag-id : Angular grid id can be used to get instance of angular grid from the injected angulargrid factory. Description. js services. The new Material theme has here and there some style bugs, so I went customizing another theme to look like material. Angular 7 is completely based on components. Learn more Angular material 7 use grid with drag and drop. Created: 26 April 2016. Filters in Angular JS can be applied by using the | (pipe) character followed by the filter name. This will create a FlexGrid with default behavior, which includes automatic column generation, column sorting and reordering, editing, and clipboard <option value="dark-hive" selected>Dark Hive</option>
        <option value="dot-luv">Dot Luv</option>
        <option value="eggplant">Eggplant</option>
        <option value="excite-bike">Excite Bike</option>
        <option value="flick">Flick</option>
        <option value="hot-sneaks">Hot sneaks</option>
        <option value="humanity">Humanity</option>
        <option value="le-frog">Le Frog</option>
        <option value="mint-choc">Mint Choc</option>
        <option value="overcast">Overcast</option>
        <option value="pepper-grinder">Pepper Grinder</option>
        <option value="redmond">Redmond</option>
        <option value="smoothness">Smoothness</option>
        <option value="south-street">South


will accessible.
This would imply a lawyer from the United Kingdom for a British local government website, for a German authority website it would, of course, imply the services of a lawyer from Germany.

Is it only mandatory to make site accessible for Govt. own website and for stock exchange listed corporate sites. or for all type of sites?

I can't speak as to the exact requirements, since I'm not a lawyer. However a quick Google turns up the following web-page that seems to address this question: http://www.webcredible.co.uk/user-friendly-resources/web-accessibility/uk-website-legal-requirements.shtml
To paraphrase the linked page:

The DDA makes it unlawful for a service provider to discriminate against a disabled person by refusing to provide any service that it provides to members of the general public.

I read this to mean that all websites that provide aaccord in 2010: “If they want to come back, we welcome.
“The condition is that they have to abide by Chinese law and regulations. That is the bottom line. And also that they would not do any harm to Chinese national security and national consumers interests.”
The restatement of China’s tough domestic laws runs directly counter to President Xi Jinping’s promise that the nation’s internet would “only become more and more open”.
President Xi’s comments were read out at China’s fourth annual World Internet Conference, which leading figures from several US tech giants attended, including Google’s chief executive Sundar Pichai for the first time.
Mr Pichai spoke at the forum even though the search engine has been hit by the ruling Communist Party’s hard-line stance on western websites and apps, with the


into the new millennium with a real bang. But news from the National Aeronautics & Space Administration (NASA) recently takes the issue of modern farming one giant step forward for mankind with news that very soon a new era of space farming will begin when a small Gravitational Biology Lab is delivered to the International Space Station (ISS).

ScienceDaily.com is reporting that once operational the new facility will provide environmental control, lighting, data transfer, commanding, and observation of experiments in Mars and moon gravity conditions on the space station, as well as the ability to mimic Earth's gravity for experimental applications.

With the addition of this biology lab—a subterfuge mounted work station—scientists will be able to establish seed germination boxes, plant growth chambers, animal and plant growth chambers, cell structureto 10-watts for your Sony and LG phones, and can optimize to 9W for Samsung. The LED indicator let you know how things are going while the rubber ring holds the handset in place. The cable is five feet long so you can plug into the out-of-the-way outlets. Purchase for $ 45 from Amazon or $ 60 from Belkin.

Samsung Fast Charge Wireless Charger Pad

When it comes to smartphone popularity it’s Samsung’s pie and the rest of the players share pieces of it. If you want official accessories, this is the charger you go with for Samsung devices.

It’s about 1.4x times faster than conventional wireless tech, has a circular strip of rubber to prevent your handset from sliding around, and a bright LED to indicate charging. Offered in Black,


the
trial court he had unspecified psychiatric problems and memory loss the night of
the crime following prolonged drug use.  A person is incompetent if he does
not have a sufficient present ability to consult with his lawyer with a
reasonable degree of rational understanding, or a rational as well as factual
understanding of the proceeding against him.  TEX. CODE CRIM. PROC. ANN. art. 46.02, § 1A(a) (Vernon Supp.
2004).  A person is presumed to be competent to stand trial unless proven
to be incompetent by a preponderance of the evidence.  Id. art.
46.02, § 1A(b).  The trial court must conduct a hearing on the issue of
competency upon the trial court’s own motion or upon the written motion of the
defendant or his counsel if the courttry to dissect why the economy is doing poorly now, and to make policy corrections.

To begin with, some history. India had many achievements to be proud of during the first four decades after its independence — a vibrant democracy, secularism and freedom of speech, comparable to many advanced economies — but economic growth was not one of them. India’s growth picked up only after 1990 and in three broad steps. It began with the reforms initiated by Manmohan Singh, with Narasimha Rao as prime minister, in the early 1990s, which got India growing annually at nearly 7 per cent, which at that time was quite an achievement. The second uptick happened around 2003, and a part of the credit for this goes to Atal Bihari Vajpayee as PM.


The Barclays Premier League champions will first be without the Belgium goalkeeper for Saturday's match at Everton after Courtois suffered the injury in training.

"Courtois was injured in a training session with the goalkeepers and I cannot tell you much, but I can tell you that he needs surgery in his right knee," Mourinho said.

Transfers Transfer news LIVE - PSG confident of signing Dele Alli 8 HOURS AGO

"As a consequence of that he will be out for quite a long time. I cannot be at this moment more specific about the injury or the time he will be out."

It is another blow for the Blues, who have four points from their opening four games and sit eight points behind leaders Manchester City.

transfers Edouard Mendy having Chelsea medical - LampardCartagena transferred the defendant's case to the Board's fugitive investigation unit, and the Board issued a warrant for the defendant's reimprisonment.[3]
About two months later, on February 20, 2007, Officer Cartagena learned from a confidential source that the defendant was living with Ms. Moseley in the Fair Haven section of New Haven. Though the defendant's case had been transferred to the fugitive investigation unit, Officer Cartagena followed up on this tip himself. His investigation confirmed that the defendant was staying with Ms. Moseley at her apartment on the first floor of a multifamily house at 189 English Street. Officer Cartagena immediately notified the person in the fugitive investigation unit responsible for the defendant's case, Daniel Barry.
Officer Barry reviewed the defendant's record and decided that an attempt should be made


analysis using one-way ANOVA and post hoc Tukey's test to analyze the difference of the micro-shear bond strength, and chi-square test/Fisher's exact test for the failure mode frequency of the micro-shear bond strength test specimens at a significance level of P=0.05. The micro-shear bond strength of the three concentration EDC treatments were (35.29±8.97) MPa (0.01 mol/L EDC treatment group), (40.24±9.68) MPa (0.3 mol/L EDC treatment group), (37.38±9.66) MPa (0.5 mol/L EDC treatment group) separately; and that of the 80% ethanol group was (37.49±7.76) MPa. All micro-shear bond strength value of the above four groups was statistically higher than that of the blank control group [(33.81±7.98) MPa]. The immediate micro-shear bond strength and failure mode was of no statistically significant difference among all the groups. It was noticed thatcan kiss that market advantage goodbye.

One way or another, Jobs and Apple will learn two lessons:
Never pick fights with people who can buy 100101110s and 0110110110s by the barrel, and never pick fights with your loyal customers and partners.


Q:

why cant't direct visit hashmap static variable

When I study HashMap source code, I found the HashMap class have many static variable, sush as:
public class HashMap<K,V>
extends AbstractMap<K,V>
implements Map<K,V>, Cloneable, Serializable
{
    /**
     * The default initial capacity - MUST be a power of two.
     */
    static final int DEFAULT_INITIAL_CAPACITY = 16;

    /**
     * The maximum capacity, used if a higher value is implicitly specified
     * by either of the constructors with arguments.
     * MUST be a power of two <= 1<<30.
     */
    static final int MAXIMUM_CAPACITY = 1 << 30;

    /**
Eric Pickles, the Secretary of State for Communities, has published new figures showing that one London family cost £345,718 in police call-outs, ambulance alerts and social services interventions over the course of a year.

The household in Barnet, north London, is thought to be the most expensive encountered by officials as part of efforts by the Government to tackle the 120,000 “troubled families” who cost the state £9 billion a year in crime, anti-social behaviour, disruption in schools and health problems.

The figures do not include money paid out to the families in benefits so the cost to the taxpayer could be even higher.

The data, released by the Department for Communities and Local Government (DCLG), also shows that one single-parent family in the south west of England cost local agencies


including the council and police force more than £400,000 in just two years.

One member of that family cost the public purse over £290,000 in a year, the report said.

A family in Salford, Greater Manchester, previously thought to be the country's most dysfunctional, was last year tracked down by the Daily Telegraph and found to have cost around £200,000 a year.

Samantha Galbraith and her children are believed to have cost taxpayers around £1million during a decade of anti-social behaviour.

The Prime Minister has promised £448 million to be given to councils that help these families avoid “social failure” and turn their lives around.

Councils will be paid for helping families find work, cut anti-social behaviour, attend school regularly and cost taxpayers less overall.

The local authorities are expected to identify the familiesand communities,” Mr Pickles said at a Local Government Association conference on troubled families

“The savings we can make for the taxpayer would far outweigh the extra money we are putting in.

"Momentum is building behind this work and we will do much more in 2013. “We will start showing the communities around these families that things are changing for the better, with kids back in school, crime coming down and parents sorting out their problems and getting back towards work. And we will do all this in bigger numbers than ever before."

Mr Pickles said that councils will save billions of pounds by intervening in problem households.