the transcripts encoded in the genome, the Berkeley *Drosophila*Genome Project (BDGP) initiated a high throughput production of both EST and full length cDNA sequences based on conventional and normalized cDNA libraries from different tissues and developmental stages \[[@B2]\]. This effort was followed by non-BDGP projects with a major contribution from the Exelixis *Drosophila melanogaster*EST project, which has adopted sequencing of random primed libraries of mixed stage embryos, imaginal disks, and adult heads to increase the transcription units coverage \[[@B3]\]. Currently, there are about 39,346 full length mRNA and 532,557 EST sequences available in the NCBI database, totalizing approximately 16,681 clusters according to UniGene \[[@B4]\]. Since the year 2000, several subsequent genome versions have been released, each one improved by BDGP and annotated by FlyBase \[[@B5]\]. Release 3.2, consideredsurveys designed to identify coregulated expression patterns between unannotated and annotated genome regions, it was estimated that 29% of the unannotated regions are part of transcripts incompletely annotated or potential alternative exons of known genes \[[@B11]\]. Therefore, correcting and refining the genome annotation is a reiterative task, which is continuously being done and depends on experimental data for final validation, especially for the identification of rare transcripts and alternative splice variants. With the aim of covering the diversity of transcripts expressed in *Drosophila*the generation of EST information from different sources is currently under way \[[@B2],[@B3]\].

Here we use the Open Reading Frame Expressed Sequence Tags (ORESTES) methodology, which is based on low stringency RT-PCR, to generate *D. melanogaster*expressed sequence information. ORESTES are preferentially derived from the central coding portions


         CycT (CG6292)                Isoforms 3.2--4.3
  15        [EG974105](EG974105)^•^   33A1--2               Intron                       1.8; 5.0; 9.8                    crol (CG14938)               Isoforms 6.2--7.1
  16        [EG974142](EG974142)^•^function of these new enzymes in the defense response.

![**Induction of the SP212 mRNA in adult flies after infection with different microorganisms**. Northern blot analysis of total RNA extracted from adult flies at different times (3, 24 and 48 hours) after challenging by pricking with a needle dipped into 10^9^cells/ml cultures of either Gram^+^(*S.aureus*) or Gram^-^(*E.coli*) bacteria or fungi (*A.fumigattus*). Note that asceptic pricking by itself triggers the induction of the SP212, albeit at a lower level.](1471-2164-8-249-5){#F5}

Conclusion
==========

The analysis of a relatively small set of ORESTES allowed the validation of 17 novel exons present in low abundance transcripts, and led to the cloning of a new serine peptidase that is induced during the defense response. These results illustrate the importance of PCR-based approaches as complementary tools for the identification of


Template preparations were performed as described by Dias-Neto and colleagues \[[@B12]\] with some minor modifications as follows: 15 ng of purified mRNAs were used for cDNA synthesis and amplification, using RT-PCR beads (Amershan-Pharmacia Biotech, USA) and a set of randomly selected oligonucleotide primers (15 to 20 mers). ORESTES profiles were generated after a cDNA synthesis step at 42°C for 60 mins immediately followed by cDNA denaturation at 75°C and amplification by PCR using a multiple annealing step. The annealing was performed for 10 secs at each temperature and the temperatures varied from 66°C to 44°C (with progressive reductions of 2°C), within each cycle. Primer extension was performed at 72°C for 1 min and denaturing at 95°C for 45 secs in 40 cycles. A final extension step at 72°Clessen bureaucracy and give efficient service to the people by doing away with paper works.

Free grant search with the aid of the internet is made much more convenient and efficient by the presence of these online government websites.

It may take a lot of research and you may even need to hire help to write your grant proposal, but if you can secure funds to help you get your business off the ground then all the hard work will be worth it.


was a question.

"Sure." She turned back toward him, grabbed his face between her hands, and kissed him full on the lips.

He forgot all about chivalry and boundaries and fear. He clamped her to him, lifting her up and walking her backward through the open door, his lips never leaving hers. Once inside, he kicked the door shut behind them, slanting his mouth sideways so he could see where he was going. The room was a blur of bright colors and textures, and he couldn't focus because she was raking her hands through his hair, her tongue was playing tease with his, and her breasts were lush and soft against his chest.

"Couch?" he managed to growl against her mouth.

"Bed," she croaked hoarsely, gesturing wildly to their side. "Bed."

He lookedthrough a west-facing window, and at least ten crystals hung from the curtain rod. She glanced to the other side of the room and noticed the east window treatment was the same. Yep, she was in Bisbee, all right. Crystals, incense, and flutes in the background were part of the local flavor.

"So you're not from Bisbee, then?" Esmeralda asked.

"No. I'm on a six-month sabbatical from the U of A in Tucson." The dancing rainbows swirled over the furniture, which was upholstered in a variety of fabrics. Kate searched for a sign of cats but didn't see any. Maybe they were in another room.

"And your area of expertise is?"

Kate turned to her with a smile. "Monkeys. I'm a primatologist."

"How fascinating!"

"I happen to think so. So where are the cats?"

"Right


foreplay. _Yikes_.

The instant chemistry put things in a whole new light. Jon had come here to escape, which meant he'd taken great pains to keep this location secret. Though she felt ambushed by her strong reaction to him, she couldn't help but smile as she thought of a twist on the old Vegas line—whatever happens in Bisbee stays in Bisbee.

Was she seriously thinking of getting involved with Jon this week? Surely not. But he had made that remark about feeling as if they were back in high school, which was sort of an invitation to explore further. She couldn't deny fantasizing about what he'd be like as a lover. With his security precautions, she wouldn't have to worry about some paparazzo leaping out of the bushes with aThe NM dietary treatment group (3) resulted in increased survival over the control diet group (2) mice, as shown in the Kaplan--Meier survival curve (Fig. [6](#Fig6){ref-type="fig"}). The longest survival time (22 days) for groups was reached by a mouse in group 3, whose survival was 5 days longer than that of group 2 mice. Group 3 mice exhibited a mean increase in survival time of 1.4 days over that of group 2 mice, which showed a mean survival time of 15.2 days versus 16.7 days for group 3 mice. Group 4 mice had a mean survival time of 15.2 days. Fig. 5Representative **a** spleens, **b** livers, and **c** spleen sections and **d** liver sections from Control and NM-supplemented nude mice receiving intrasplenic injection of 10^6^ B16FO cellsTable 2Effect of 10^6^ B16FO cells administered into spleens of male


(5.5 mg/mL) and plasminogen (50 μg/mL). After electrophoresis, the gels were washed twice with 2.5% Triton X-100 for 30 min. The gels were then incubated overnight at 37°C with 0.1% glycine buffer pH 7.5 and then stained with 0.5% Coomassie Brilliant Blue R250 and destained. Electrophoresis of u-PA was conducted for comparison. Fibrin zymograms were scanned using CanoScan 9950F Canon Scanner. TIMPS were analyzed by reverse zymography on 15% SDS gels containing serum-free conditioned medium from cells. After electrophoresis the gels were washed twice with 2.5% Triton-X for 30 min at room temperature to remove SDS. The gels were then incubated at 37° overnight in 50 mM Tris-HCl and 10 mM Ca Cl~2~ at pH 7.6 and stained with 0.5% Coomassie Blue R25, destained and scanned.

The results obtained with prostate PC-3 cell line, presented here, arepositive correlation (*r* = 0.977) between PC-3 u-PA and MMP expression (Fig. [9e](#Fig9){ref-type="fig"}), a negative correlation (*r* = −0.939) between expression of u-PA and TIMP-2 (Fig. [9f](#Fig9){ref-type="fig"}) and a negative correlation (*r* = −0.781) between MMPs and TIMP-2 (Fig. [9g](#Fig9){ref-type="fig"}).

### Nutrient synergy has inhibitory effect on cancer cell migration {#Sec12}

To study cell migration, a 2-mm wide single uninterrupted scratch was made from top to bottom of culture plates of cancer cells grown to confluence. Culture plates were washed with phosphate-buffered saline (PBS) and incubated with NM in medium and tested at 0, 10, 50, 100, 500, and 1,000 μg/ml in triplicate at each dose for 24 h. Cells were washed with PBS, fixed and stained with H&E and photomicrographs were taken. A representative example is shown with bladder cancer cells \[[@CR39]\]. NM reduced bladder cancer cell line T-24 cell


Profiling of immune-related microRNA expression in human cord blood and adult peripheral blood cells upon proinflammatory stimulation.
Cord blood (CB) transplantation has advantages in terms of incidence and severity of acute graft-versus-host disease (GVHD), while it has disadvantages in terms of infection. Our aim is to elucidate the molecular mechanism underlying the immune response of CB-derived cells during acute GVHD and infection following CB transplantation. We examined expression of 69 immune-relating microRNAs in CD4(+), CD8(+), and CD14(+) cells of CB and adult peripheral blood (APB) upon interferon-γ or lipopolysaccharide (LPS) stimulation. Under basal condition, 20 microRNAs showed differential expression between CB and APB. Compared to APB counterparts, six microRNAs (miR-21, miR-22, miR-29a, miR-29b, miR-29c, and let-7c) were underexpressed in at least two cell lineages of CB, while five microRNAsEgypt is right by the Middle East, and Egypt and Sumeria did have extensive trading with each other. Just because “Egypt is in Africa” doesn’t mean that they were black. The whole of North Africa are Caucasoids.

Rome and Carthage went to war and Hannibal gave the Romans a run for their money. Which anytime you can give the ROMANS a fight, you’re a bona fide badass.

I definitely agree that if you can give Rome a fight, you are a bad ass. But there’s one problem: Carthage was a Phoenician civilization, not sub-Saharan African. The “picture” you use of Hannibal is NOT an accurate portrayal of what he actually looked like.

He looks pretty damn Caucasoid to me. This fantasy of Afrocenstrists to insert themselves into most any important event


in world history just to say they did something worth talking about truly shows the inferiority complex of blacks.

Also, to see what Phoenicians really looked like, look to Sardinians. Due to genetic isolation from being on the island, they have hardly any admixture from outside the island. They also speak a Phoenician language.

If you’re a Greek Mythology buff like myself, look up a brother named Memnon. Speaking of Greek Mythology, look up Andromeda, Perseus’ wife and see where she’s from. Here’s a hint. And by hint I mean answer: Ethiopia.

Are we to take all peoples of antiquities word for everything they say? Are we made of corn? Is the story of Romulus and Remus true? Were there gods on Mount Olympus?

Again. Just because they were present, doesn’t meanjust isn’t realistic for what I want. I’ve read about all the different types of RVs and other vehicles that can be converted into a home, and I think I’ve narrowed it down to one of three options: class B motor home, truck camper, or a converted minibus. I’ve chosen these three options for a number of reasons:

I’m not comfortable driving excessively large vehicles which pretty much rules out the Class A and Class C motor homes. I also want to be able to park the vehicle in any parking lot without a lot of trouble. For these reasons, I need something small and accessible.

I don’t have a vehicle that can tow large items such as pop-up trailers, travel trailers, and fifth wheels. Plus I’m trying to keep


              data: JSON.stringify(responseBody),
                cache: false,
                dataType: 'json',
                beforeSend: function (xhr) {
                    xhr.setRequestHeader("Authorization", "Basic " + btoa("" + ":" + _token));
                },
            }).done(function (data) {
 simulate fluid dynamics).

When the going gets tough, the tough reach for their C/C++ compilers. :)

------
devnonymous
If you don't know C, I would recommend to invest time in learning that first.
Learning C++ would certainly not be a waste of time. However, if you want to
be efficient about the use of your learning time, choose the
technology/languages that would come in handy for what you would like to do
next.

C++ is seeing a revival of sorts due to IoT/Automotive/Fintech software etc.
So from a career perspective it would be a good investment of time (if, for
instance, you are inclined to work in those fields).

However, keep in mind what is being called Modern C++ (c++11 and later) is a
completely different beast than C++ which is uttered in the C/C++ sense.

My prediction is that the reality


(e.g. it
means different forms of resource cleanup are possible:
[https://codewithoutrules.com/2016/03/10/compare-
contrast/](https://codewithoutrules.com/2016/03/10/compare-contrast/)).

On the other hand, it's also a massive language, and modern C++ is very
different than the legacy code bases you'll encounter in the real world. So
it's a large time commitment to learn it well enough to code well in anger.

If you have the time try skimming a tutorial, and doing some exercises, enough
that you can get the differences in mindset. But it's probably not the most
efficient way to increase earnings, if that's all you care about.

------
kahrkunne
It's always worth it to learn more languages. Every developer should learn C
imho (it's a very widely used, influential language and it's pretty small).
Seeing how C++ is essentially a superset of C, you might as well check it out
after you learn C.

Also, don't focus onAnd Sober” Witness!

He would begin to feel an intense burning on his arms several minutes later. By which time, the strange object had reappeared and disappeared a third time. He would recall:

My only thought was to get somewhere and let someone know what I had seen!

Shortly after he would arrive in Lavonia where he would stop momentarily so he could wash the oily residue from his arms and his car. However, despite several attempts, the burning sensation in his arms persisted. And the oily markings on the car’s exterior was clear for all to see.

Nevertheless, he would jump back in the car and drive to Anderson Air Force in South Carolina. Once there, he would report the incident to the Federal Aviation Authority (FAA) as well as the


who were seemingly aggressive, to say the least

Perhaps strangest of all, not to mention ominous, was the fact that despite their not reporting the sighting, a military spokesperson would “arrange a meeting” at a neutral but out-of-the-way location, during which he was interrogated and “encouraged” to change his version of events.

Several weeks later on the morning of 22nd September, an incident later known as the Big Sur UFO Film incident would unfold in Santa Barbara County, California. On that particular morning, an apparent UFO of unearthly origin seemingly attacked and disabled a nuclear missile during a test mission. One researcher to the incident would claim this was a “purposeful demonstration” of their technological superiority. Others, however, took it as a further threat from such cosmic visitors regarding humanity’swhere Blackfire destroys all the probes with light purple-colored blackbolts from her eyes. When Robin asks her how she did it, she replies with a hint of a smile that it was just a lucky guess. Cyborg remarks that they need that kind of luck and offers Blackfire a spot on the team. Starfire, who is still recovering from the attack, gasps in shock.

Starfire is sad about this at first, but then comes to the decision that the team will be better off without her, and decides to leave. Just when she is about to leave Robin appears and starts to talk to her but just then, the aliens who sent the probes show up and take Starfire captive. Robin attacks their ship and sets her free, but


just as the other Titans show up and prepare to battle, the aliens announce that they are Centauri police, here to capture a Tamaranean thief, who they say is Starfire because she's a Tamaranean and because she was wearing the Centauri Moon diamond that Blackfire gave her, but she'd never even been to the Centauri Moons. But the Titans know who has been to Centauri and that there's another Tamaranean on Earth. Seeing the Centauri Moon diamond on Starfire, Robin realizes they must be talking about Blackfire because she's been to the Centauri Moons; that's where she'd gotten the diamond, and she told Starfire herself. It all turns out that Blackfire had stolen the diamond and gave it to Starfire and was only pretending to be the Titans'be from the early 90s. It looked "clean" quality-wise, like an american film, and I think it used CGI for the mirror effect, where it looked like the mirror was liquid when the guy grabbed inside of it.
the characters look over a grave near the end (along with the guy who lost his hand)

Does anybody know the name of that movie?

A:

It kinda sounds like Stephen King's Rose Red. There was a scene near the end of the final part in the miniseries when they where escaping the mansion when a character that had recently died turned into a ghost and was attempting to pull the man into the mirror and a guy manages to help him get free.


comes with many benefits, it also comes with consequences. Ann Smarty pointed out some of “The Bad” associated with social media in an article called “Social Media and Society: The Good, the Bad, and the Ugly.” She brings up the valid point that often people hind behind their screens because it gives you a feeling of being social without actually socializing. Some additional issues include the permanence of everything you post. Jenny Q. Ta talks about what a large issue cyber bullying has become using social media as an outlet.

Personally, I use social media as a way to keep friends and family up to date on my life. More recently, I have started using it as a way of branding myself in my photography such as sharing linksEven though it was announced less than three months ago at the Code Conference, there's already enough mythology surrounding the Essential Phone to fill a book. It comes from a brand-new billion-dollar startup led by the person who helped create Android itself, Andy Rubin. That origin binds it up with the history of all smartphones in a way that doesn't usually apply to your run-of-the-mill device. The phone was also delayed a bit, a sign that this tiny company hasn't yet quite figured out how to punch above its weight class — which it's certainly trying to do.

Although it runs standard Android, it's meant to act as a vanguard for Essential's new ecosystem of smart home devices and services connected by the mysterious Ambient OS. Even if we


into the monolithic aesthetic it's created here without the need for a camera bump. (Here’s a nice explainer on how Huawei’s similar system works.)

Now, the complicated part: a mere eight or so hours before we needed to publish this review, I got a software update for the camera that added a manual HDR mode. More importantly, the update improved image quality — in some cases drastically. What was yellow and flat before became punchier and more contrasty. Where before I would have described the low light performance as “a dumpster fire but worse because you can at least see fire in the dark,” now it’s approaching something like respectability.

I’ve tested it up against the Pixel XL after the software update in low light and in our office andthe Phone for $50 extra (for a limited time). I've only had it for a couple of days, so I can't give more than a few basic impressions.

My first impression is that it, you know, works. You snap the camera on the back of the phone, it launches a custom version of the camera app that is capable of taking 360-degree still images or video in 4K, and that's it. Remove the camera and everything just toodles along. It seems like a small thing, but it's absolutely possible for a company to screw up hot-swapping accessories.

It is nice that the camera itself is so small and pocketable and that I don't have to remember to charge up yet another thing at night. The images and videos it produces


"I have men downstairs!" "They can hear everything." "There is a reason why they sent me." "You understand?" "You have to be quiet." "They wouldn't let me see him, Leo." "They wouldn't let me see my boy." "Alexei, please, will you just..." " No, you tell me." " Read the file." "Tell me." "What should I tell her?" "My wife." "You tell her whatever it takes to protect every single body in that room." "Everybody in there, who you love, you tell them whatever it takes." "Do you understand?" "And you let him go." "Alexei, there can be no murder in paradise." "(SOBS)" "Remember?" "There's a witness, Leo." "Excuse me?" "A woman." "What do you mean?" "She saw that man." "She saw the man who took my boy."get here if it was not for train?" "And then the boy in Moscow." "Again with Moscow." "This boy in Moscow is the son of a very good friend of mine." "My brother." "I was sent to his house to read official report." "I had to tell his family that his son died of tragic accident." "And I lied." "So I'm thinking, how many more children have to die?" "Get swept under the carpet." "Covered up by party dogs like you and I." "And their blood is on our hands." "And this animal, he will not stop killing." "This will not stop." "He will keep killing and killing." "Enough!" "What do you want?" "Me?" "I would like to stop him." "A ghost." "Ghost?" "No, it's not ghost." "Describe


to Moscow at, I assume, great personal risk." "Mmm-hmm." "Why?" "LEO:" "You see, (CLEARS THROAT) each of these children have been murdered over the past several years and each of these individual cases has been solved by the state, the perpetrators dealt with." "But if you look very closely and examine the children, they have all been killed in a similar manner." "So what you're saying is somebody is responsible for this?" "LEO:" "Absolutely." "And this somebody is still out there." "RAISA:" "Yes." "A murderer." "You're saying there's a murderer?" "Without doubt." "You do realize there are no murderers in paradise?" "So you two are working together now?" "As what?" "Outraged citizens?" "RAISA:" "Sort of." "Yes." "Going to capture this troll by yourselves?" "Somebody has to." "Ivan, look"She's a teacher." "She teaches children." "Eh?" "Hello." "Elena, Tamara." "Why don't we all sit down?" "It's much nicer sitting down." "Da." "RAISA:" "We would like, if you want, to give you a home, our home." "LEO:" "Yes." "You came to our farm." "I mean..." "Yes." "Yes, I did." "I did." "But, um..." "Um..." "We want to look after you, take care of you." "As my husband said," "I can teach you how to read, write." "We can go to parks." "We have friends." "There are a lot of things we can do." "I can't bring your parents back." "I can't." "I can't do that." "It's not possible." "I would like to." "Of course, I would." "But I can't." "And I am sorry." "I am truly very sorry."


 self.total = total
        }
    }

I have cleared my ViewController and has basic setting in it.

A:

Firstly you'll need to do a web request to your servers script. You should use URLSession or use something like the Alamofire or AFNetworking libraries which will do a lot of the web request lifting for you. I'd recommend using URLSession as this will teach you what's going on under the hood. Once you have done a Get or Post request to your server script your server will return a response. I would also recommend that your PHP script gets the data from your server and returns JSON format which your app will need to parse to present and work with theout. However, no experimental evidence that could provide insight into the functional role of this surface was found reported in the RILM database [@pone.0003667-GarzaGarcia1] or in the NCBI SNPdb [@pone.0003667-httpwww.ncbi.nlm.nih.govprojectsSNP1]. Furthermore, an evolutionary trace (ET) [@pone.0003667-Morgan1], [@pone.0003667-Mihalek1], [@pone.0003667-Lichtarge1] run was performed for the IR MSA, as described in the [Materials and Methods](#s3){ref-type="sec"} section. ET is an evolution-entropy hybrid method that assigns a relative score of functional importance to each sequence residue and subsequently ranks the residues by importance. Consistent with the likely acting high selective pressure, ET ranked first those hydrophobic residues located in the interior of the protein as well as some residues at the monomer-monomer and inter-domain interfaces (rho≈1.00), whereas residues comprising both the receptor binding site in L1 and the proposed binding site 2 scored


of generation plots, comparison of the arithmetic and harmonic ln*L* means of the two replicate runs, and calculation of symmetric Robinson-Fould tree distances within replicates of the same run (using the MrBayes sump output) and Treedist of the Phylip package [@pone.0003667-Felsenstein1] to compute these distances between the majority rule consensus trees obtained from each independent MC^3^ run (all provided in [Supplementary File S1](#pone.0003667.s001){ref-type="supplementary-material"} and [Supplementary File S2](#pone.0003667.s002){ref-type="supplementary-material"}).

The overall resolution of Bayesian and ML trees was evaluated by computing diverse descriptive statistics of the SH-like *P* values or Bayesian posterior probabilities parsed from the corresponding phylograms using *ad hoc* Perl scripts [@pone.0003667-Shier1].

Calculation of Consurf Conservation Scores {#s3d}
------------------------------------------

The conservation scores at each amino acid position were calculated with the Rate4Site algorithm [@pone.0003667-Pupko1], under the maximum likelihood (ML) principle providing bothfor both the IR and the IGF1R ectodomains

(0.02 MB ZIP)

######

Click here for additional data file.

######

Zip file containing Evolutionary Trace results for the IR

(0.75 MB ZIP)

######

Click here for additional data file.

######

Zip file containing PDB structures obtained through normal modes calculations.

(1.20 MB ZIP)

######

Click here for additional data file.

We are grateful to Eleanor Morgan and Dr. Steve Bottomley for their kind advice and valuable discussions. Moreover, MER gratefully acknowledges the Peace Scholarship Program and the Secretariat of Public Education of Mexico for making possible his stay in Australia as a visiting scholar.

**Competing Interests:**The authors have declared that no competing interests exist.

**Funding:**Western Australian Biomedical Research Institute and School of Biomedical Sciences and School of Pharmacy, Curtin University of Technology

[^1]: Conceived and designed the experiments: MER EH RLM.


Q:

What is the difference between Jacobian of maps between manifolds and matrix representation of its differential?

In An Introduction to Manifolds by Loring Tu p.67 and 91, the author first defined the "Jacobian matrix" (see the picture) of maps between manifolds relative to corresponding charts. And then in p.91, he discuss local expression of differential (which is a linear transformation between tangent spaces) and discuss its matrix representation. However, I want to ask is these two things literally the same?

A:

If you have a map $ f : U \to V$ between open subsets $U \subset \mathbb R^m, V \subset \mathbb R^n$, then the derivative at $p \in U$ is the best linear approximation of $f$ in $p$. This is the (unique) linear map $df(p) : \mathbb R^m \to \mathbb
85 A.2d 493 (1952)
SABOURIN et al.
v.
WOISH et al.
No. 525.
Supreme Court of Vermont.
January 2, 1952.
*494 Sylvester & Ready, St. Albans, for plaintiff.
*495 John H. Webster, Swanton, for defendant.
Before SHERBURNE, C. J., and JEFFORDS, CLEARY and BLACKMER, JJ.
SHERBURNE, Chief Justice.
This is an action of tort in two counts. The first count alleges, among other things, that the defendants occupied a house of the plaintiffs from about April 1, 1947, to about October 1, 1949, whereby it was the duty of the defendants, while occupying the property as tenants of the plaintiffs, to occupy the same in a good husbandlike manner, commit no waste, permit no waste to be committed, to pay the plaintiffs a fair and reasonable compensation for the use of the property, and to vacate the same upon


Neurotrophins, such as NGF and BDNF, are prominent regulators of neuronal survival, growth and differentiation during development of the vertebrate nervous system. They also play an important role in higher order functions, such as pain, addiction, mood disorders and learning and memory. A major problem in the field is to explain how neurotrophins are able to carry out these diverse activities through receptor signaling. The actions of neurotrophins are dictated by two cell surface receptors, Trk tyrosine kinases and the p75 receptor. We are interested in the role of Trk receptor signaling in dictating neuronal responsiveness by neurotrophins. In the next grant period, we will focus upon a multifunctional scaffold protein called ARMS/Kidins220, which is a principal substrate of Trk receptors. This protein is heavily tyrosine phosphorylated bySince I've had the assignment of staying in touch with people who have not joined a CPUSA club, I've corresponded with wonderfully interesting people from all over the remote parts of the United States. None was more interesting than the Reverend Paul White, who wrote the essay below to me:

I became a Marxist during the 1960s. I was ordained as a Baptist pastor in 1987. I remember telling my oldest son, when he was still a very young man, about my civil rights and anti-war activities during the 1960’s and how my involvement in those movements moved me toward Marxism. He asked what had caused me to renounce Marxism and become a Christian. I told him I had never renounced Marxism, I had simply switched nouns and adjectives.


DRD1 rare variants associated with tardive-like dystonia: a pilot pathway sequencing study in dystonia.
The dystonias are a clinical heterogeneous group with a complex genetic background. To gain more insight in genetic risk factors in dystonia we used a pathway sequence approach in patients with an extreme dystonia phenotype (n = 26). We assessed all coding and non-coding variants in candidate genes in D1-like subclass of dopamine receptor genes (DRD1, DRD5) and the synaptic vesicle pathway linked to torsinA (TOR1A, STON2, SNAPIN, KLC1 and THAP1), spanning 96 Kb. Two rare missense variants in DRD1 were found: c.68G>A(p.Arg23His) in the screening group and c.776C>A(p.Ser259Tyr) in an additional screen of 15 selected dystonia patients. Genetic burden analysis of DRD1 rare variants in patients (4.8%) versus European American controls from ESP (0.72%)critics who invent facts to further their own political agendas (i.e. Jack Thompson, who at the time was sadly receiving media coverage) as I start to “zoom out” from Smash Brothers itself and start to examine the overall perception of it, and gaming.

After writing Line 14, “Sucking the life out of,” I couldn’t think of what to write, so I just wrote a chain of prepositions, which were HUGE in the Latin class I was also taking at the time. I directly admit this in Line 16 when I say “Train of thought,” and concede that I couldn’t think of a coherent follow-up in Line 17: “Derailed to hell.”

Lines 18 through the end are self-explanatory.

Is it frightening that I can deconstruct my own ten-year-old poem as specifically as


double negations were rephrased, and the expression "lung disease" was changed to "COPD". See Table [1](#Tab1){ref-type="table"} for the original and revised item texts.

Preparing the data for psychometric analysis {#Sec12}
--------------------------------------------

A large number of items had low endorsement (n \< 10) for at least one response option/category. This can cause problems in psychometric analyses; hence, the problematic categories were merged with adjacent categories for these items. Note that items having different numbers of response categories due to merging does not constitute a problem for the GRM, nor does it hamper the comparison of item discrimination parameters (estimated with the GRM) among items. See Additional file [3](#MOESM3){ref-type="media"} for the R code used to merge item categories. Three items were removed at this stage, due to a large number of missing values (\>20 %) perwas acceptable (n = 4; data not shown).

As mentioned previously, three items (items 6, 7 and 8) were excluded prior to analysis since they had \>20 % missing values.

We thank Professor Paul Jones, Professor Giulio Vidotto, Professor Grégory Ninot, and Rianne Maillé for granting us permission to include modified versions of items from the SGRQ-C, MRF-26, VQ11, and QoL-RIQ, respectively. We thank all patients that participated in this study for their valuable input. Finally, we thank Mitzi Paap, Bachelor of Arts in English Language and Culture, for translating the items from Dutch into English.

Funding {#FPar1}
=======

This study was supported by grant \#3.4.11.004 from Lung Foundation Netherlands.

Authors' contributions {#FPar2}
======================

MP and JP designed the study. LL and NH collected the data with the help of JP; MP, KK, NH and LL analysed and


lack of long-term outcomes, this approach is still considered experimental and should be performed under a research protocol.

4. Which patients with CNP benefit from EUS?
--------------------------------------------

After expert multidisciplinary discussion and review of CT or MRI imaging, can we determine which patients benefit from further EUS evaluation? Patients with solitary subcentimeter or multiple subcentimeter pancreatic cysts in the setting of a normal pancreatic duct are unlikely to benefit from additional EUS evaluation, as the likely diagnosis here is a BD-IPMN, with the chances of having a cancer or developing an invasive cancer before the next interval noninvasive surveillance being very low.[@b77-gnl-09-571] For patients with the classic radiologic features of a microcystic serous cystadenoma, including a central stellate scar, the addition of EUS rarely alters diagnosis, management or outcome. Rarely, thenot just for existing or new IPMN, but also because of the increased risk of concomitant pancreatic ductal adenocarcinoma. Patients with invasive IPMN should be managed and surveyed as per PDAC guidelines. Patients with noninvasive IPMN should be surveyed based on the findings of the residual pancreas. The largest remaining cyst should dictate surveillance strategies per recent guidelines. For patients without cysts in the residual pancreas, then surveillance imaging at an interval of 2 years is recommended. For those, who in addition also had low-grade or moderate-grade dysplasia at the resection margin, more close surveillance imaging every 6 months is warranted.

FUTURE DIRECTIONS
=================

1. Multidisciplinary management
-------------------------------

The lack of accurate imaging and cyst fluid biomarkers, makes the precise management decisions for pancreatic cystic neoplasms (i.e., surgery vs surveillance) more difficult. This


by AEs; 97.5% of patients suffered from AEs, mostly expected (90.5%) and not severe. Gastrointestinal symptoms predominated. Six (7.4%) patients presented with a suspected unexpected serious adverse reaction: drug reaction with eosinophilia and systemic symptoms (n = 3), Quincke edema (n = 1), acute myocarditis (n = 1), and anaphylaxis (n = 1). Patients with 3 or more AEs had an increased risk of premature treatment termination (hazard ratio, 8.42; 95% confidence interval, 1.6-45.5). Nifurtimox is poorly tolerated among adults with chronic Chagas disease, resulting in a low treatment completion rate. Considering the significant risk of serious AEs, close monitoring is required, which may be difficult to implement in poor rural areas of countries of endemicity. The safety and efficacy of nifurtimox and benznidazole should be compared tocosts associated with the ease of material synthesis and device fabrication, makes PeLEDs an attractive candidate for display applications. Within a short span of 2 years, works carried out to further enhance device performance (such as by tailoring the interfacial charge transport layers,^[@ref13]−[@ref15]^ employing a polymer-perovskite blend,^[@ref16],[@ref17]^ and using solvent engineering techniques to enhance film formation^[@ref18],[@ref19]^) have given rise to improvements in current efficiency of up to 42.9 cd A^--1^ and in external quantum efficiency (EQE) of up to 8.53%.^[@ref18]^ Despite its outstanding potential, long-term stability has been one of the major concerns hindering its widespread use. Moisture exposure can induce degradation of the material due to the affinity of organic cations to water molecules.^[@ref20]^ Moreover, its thermal stability is also governed by the low-temperature sublimation of the


organic cations. Fully inorganic perovskite materials have been reported by substituting the organic cation with Cs^+^, giving the materials higher resistance to thermal degradation.^[@ref21]−[@ref24]^ However, research into these materials has been minimal as compared to that of their organic--inorganic counterparts. The first CsPbBr~3~ PeLED paper reported a reduced trap density with excess CsBr in the precursor solution, where the material achieved an *L*~max~ of 407 cd m^--2^ and a current efficiency level of 0.035 cd A^--1^.^[@ref21]^ The passivation of atomic Pb defects with the excess CsBr was key to reducing nonradiative decay pathways, as supported by Cho's group.^[@ref18]^ Zhang et al. also demonstrated PeLEDs employing CsPbBr~3~ nanocrystals, which achieved an improved *L*~max~ and current efficiency of 1377 cd m^--2^ and 0.19 cd A^--1^, respectively, through interface engineering.^[@ref25]^ Recently,The single PL peak for both samples (at 524 and 526 nm) also confirms the absence of Cs~4~PbBr~6~, which emits at 520 nm. Because Cs~4~PbBr~6~ has a stronger emission at excitation wavelengths of λ \> 340 nm,^[@ref45]^ to substantiate our claim, additional PL measurements were taken at various excitation wavelengths ranging from 300 to 470 nm ([Figure S1](http://pubs.acs.org/doi/suppl/10.1021/acsomega.7b00360/suppl_file/ao7b00360_si_001.pdf)). Again, no additional PL peak was observed. As Cs~4~PbBr~6~ is insoluble in DMSO, it most likely precipitated in the precursor solution. The XRD patterns shown in a previous report confirmed the presence of Cs~4~PbBr~6~ in the precipitates.^[@ref21]^ The resultant clear supernatant, which was used for subsequent spin-coating, is thus free of this impurity compound.

To investigate the charge dynamics, photoluminescence quantum yield (PLQY) and TRPL measurements were carried out and the


... We need things consumed, burned up, worn out, replaced, and discarded at an ever increasing pace.

This message sums up the advertising world of the last half-century. It’s insidious, pervasive, and deliberate – and it’s consuming us.

Our current buying behaviour has very little to do with what we need and everything to do with how having something will make us feel. Advertising points out a problem you never knew you had, makes you feel bad for having it, and then sells you a solution. The end result of this twisted process is lower quality of life, more time spent working, and horrific environmental damage due to overconsumption.

Foyster explains: “The root cause of ecological destruction from resource use isn’t overpopulation, but overconsumption. Overconsumption isn’t some vague term I madeSignificant reduction of UVB caused by smoke from biomass burning in Brazil.
Solar UVB radiation, total ozone and the aerosol optical thickness (AOT) of the atmosphere were measured at various sites in Brazil during season of 1995. Smoke from biomass burning caused very significant AOT and up to an 81% reduction in UVB at Cuiabá, hundreds of kilometers from the most widespread burning. Little or no smoke was apparent upwind of the major burning regions at and near Manaus, and UVB was close to the expected values. There is an increased incidence of respiratory, cardiopulmonary and other diseases associated with severe air pollution, but the responsible biological mechanisms are unknown. The bactericidal effects of solar UVB are well known, and significantly reduced UVB resulting from severe air pollution in


Peek inside Adam Savage's famed SF Comic-Con costume closet

Of all his costumes, Savage chose No-Face from “Spirited Away” as one of his most accessible costumes, both build- and cost-wise for cosplayers. “It's a little bit falling apart, but this is pretty much my favorite costume-wearing experience, wearing No-Face. This costume took about a week-and-a-half and cost maybe 150 bucks.” Savage said he is planning to rebuild the costume, in the hopes of making it lighter and easier to support with his body — he admitted the costume is “rough to wear on the body” given that the white face is supported by a kayak helmet. After learning that the Jim Henson Company never let actors support their costumes with their neck, he’s now thinking of how to improveI have heard of its stunning beauty. Because I have read Hamid Ismailov’s elegiac and powerful novel, The Underground, I wonder what it was like to go deep beneath the city of Moscow and travel through a metro system that some have called one of the most complex ever built. I wonder what it was like to be a foreigner and black in the confined spaces of the station and the trains.

G. tells me of the underground, of its vastness and breathtaking architecture. If one did not know the system well, he says, it was easy to get lost in the labyrinth of tunnels. There were days when he wandered unsure beneath the city, so disoriented that he went hours without seeing daylight. I imagine this: G., still


show that the OP elicited by a bright brief flash can be classified into early, intermediate, and late subgroups that are likely generated mainly by photoreceptors, action-potential-independent, and action-potential-dependent mechanisms in the ON pathway of the inner retina, respectively. ON bipolar cells themselves make only a small direct contribution to OP generation, as do horizontal cells and neurons in the OFF pathway.Q:

Incorrect table definition; there can be only one TIMESTAMP column with CURRENT_TIMESTAMP in DEFAULT or ON UPDATE clause

    CREATE TABLE `admin_user` (
      `user_id` int(10) unsigned NOT NULL AUTO_INCREMENT COMMENT 'User ID',
      `firstname` varchar(32) DEFAULT NULL COMMENT 'User First Name',
      `lastname` varchar(32) DEFAULT NULL COMMENT 'User Last Name',
      `email` varchar(128) DEFAULT NULL COMMENT 'User Email',
      `username` varchar(40) DEFAULT NULL COMMENT 'User Login',
      `password` varchar(255) NOT NULL COMMENT 'User Password',
      `created` timestamp NOT NULL DEFAULT CURRENT_TIMESTAMP COMMENT 'User Created Time',

is here is the problem--->`modified` timestamp NOT NULL DEFAULT CURRENT_TIMESTAMP ON UPDATE CURRENT_TIMESTAMP


unable to score once Pelfrey departed.

"I think everyone is out there playing hard, it's just we're making mistakes that obviously a big league team should not make," said Adam Dunn, who went 1 for 3 with a walk. "But we're making them, and that is what's costing us games. It's the same story every single day, it seems like. We do something that leads to them scoring a few runs, and we're not able to capitalize when we get opportunities. And we're going to have to find a way to turn it around. I don't know what it is, but we'll have to find a way."which to captivate your audience. That's why the first few seconds are so important. This is where you should deliver a teaser or unique point of view to captivate them and make them want to watch the entire video.

Coming up with the content of your video clip is only part of the big picture. Promotion is also a huge part of the process. If you market your videos well enough, you can get a 900% increase in your subscriber base in a relatively short time. Good videos are important, but so is good marketing.

You do not have to have a professional record your video for you. If your video is in focus and balanced, there's no need for professional equipment. You don't need fancy scripts or tons of


audience can be reached.

You can begin immediately to create a successful video marketing campaign. In less than a week, you should see the traffic to your site increase. When it comes to promoting your business, you won't find an easier or more effective method than video marketing.prospective interrupted time-series study. There were three periods: a 3-month pre-interventional period (from 01 January 2014 to 30 March 2014), a 3-month training period (from 31 March 2014 to 09 July 2014) and a 12-month implementation period of the prevention programme (from 10 July 2014 to 30 June 2015); the protocol has been previously published.[@R29]

*Deviations from the published protocol* [@R23]: The planned study design was a 'on--off' study over 24 months (including a 2-month pre-interventional period and a 22-month intervention period, without a training period). The first 6 months of the study were not taken into account owing to strong under-reporting of violent acts by the healthcare workers, as ascertained during study coordination meetings. To meet the study schedule, we reduced the duration of the study to 18


hypotheses, the total sample size required was 30 224 admissions with a risk alpha of 5% and the statistical power of 80%. We did not recalculate the number of subjects required; there is usually no estimation of the sample size in interrupted time-series studies.[@R30]

Statistical methods {#s2-9}
-------------------

The analyses were conducted on data obtained during the 15-month study period (that corresponded to the pre-intervention and intervention periods, without consideration of the training period). The proportion of admissions with violence committed by patients, or those accompanying them, was expressed as a rate per 1000 admissions. When the perpetrator was someone accompanying the patient, the violence was attributed to the patient.

For all outcomes, we conducted a pre--post analysis to compare rates before and during the implementation of the prevention programme using thethe 3-month training period. The dotted lines inside the scatter plots represents the implementation of component A (computerised triage algorithm), component BC (signage and messages broadcast on TV in the waiting rooms), component D (mediator) and component E (video surveillance). OED, ophthalmology emergency department.](bmjopen-2019-031054f02){#F2}

### Secondary outcomes {#s3-3-2}

The frequency of admissions with waiting times≥2 hours decreased from 67% (n=2755 admissions) to 52% (n=9356) between the pre-intervention and intervention periods (p\<0.001). For the length of stay, frequency of admissions with a stay≥3 hours decreased from 50% (n=2045) to 43% (n=7679; p\<0.001).

### Segmented regression analysis {#s3-3-3}

According to the Poisson regression analyses, no pre-intervention trend was found in monthly violence rates (IRR=1.13, 95% CI 0.87 to 1.46, p=0.3243). After accounting for underlying trends, an immediate 53% decrease (IRR=0.47, 95% CI 0.27 to 0.82, p=0.0121) was observed


with Democrats voting for it and Republicans against. Then, newly-amended HB 99 passed on an 8-1 vote.

SB 256 was sponsored by a bipartisan duo: Senate Minority Leader Stuart Ingle, R-Portales, and Sen. John Arthur Smith, D-Deming. The two also proposed the amendment, which Sen. Craig Brandt, R-Rio Rancho, said was unprecedented and he objected. He was lone vote against the passage of the bill itself.

The new version of the bill is essentially SB 256, which itself was similar to HB 99. While supporters say that both will be compliant with the federal REAL ID Act, there are some big differences between the two.

The new legislation does not require that those in the country legally have a REAL ID compliant card, as the original HB 99 did. In otherwhich may lead to further degeneration (Smith *et al*., [@b55]) and prevention of Aβ clearance (Hickman *et al*., [@b22]). In addition, the neurons themselves can remove the toxic oligomers of Aβ via the activation of IDE and NEP (Vekrellis *et al*., [@b60]; Carson & Turner, [@b6]). Therefore, an ideal therapeutic agent would be one that prevents the 'activation' of microglia as well as stimulating the IDE and NEP pathways in both microglia and neurons.

Although the aetiology of non-familial AD remains unclear, previous work has suggested that a deficit in retinoic acid (RA) signalling, which is essential for normal brain maintenance (Maden, [@b35]), may be associated with AD (Goodman & Pardee, [@b20]; Corcoran *et al*., [@b10]; Ding *et al*., [@b15]; Tippmann *et al*., [@b58]; Donmez *et al*., [@b16]; Jarvis


and washed three times for 5 min each in PBS-0.02% Tween. They were incubated in primary antibody in PBS-0.02% Tween at 4 °C overnight. Primary antibody was removed by washing three times for 5 min each in PBS-0.02% Tween. They were incubated in the secondary antibody for 1 h at room temperature in PBS-0.02% Tween, and then washed in PBS three times for 5 min. The coverslips were then mounted using FluroSave™ reagent (Merck, UK). Incubation of neurons with secondary antibodies in the absence of primary antibodies produced a very weak diffuse staining of cell bodies that did not overlap with the primary antibody-specific staining (data not shown).

### Brain sections

Tg2576 and 129S2/SvHsd mice were deeply anaesthetized by i.p. injection of pentobarbitone, and transcardially perfused with heparinized saline. Brainsfollowed by Fisher\'s test, *F*~3,8~ = 7.835, *P* = 0.001; for IDE, one-way [anova]{.smallcaps} followed by Fisher\'s test, *F*~3,8~ = 9.3, *P* = 0.002).

![AM 580 induces Aβ oligomeric clearance in neuronal cultures by increasing NEP and IDE activity. (A) Western blots of Aβ protein using 6E10 antibody, illustrating the formation of oligomeric forms of Aβ. (B) Immunostaining showing Aβ1-42 oligomers and RARα in cortical neuronal cultures; scale bar = 30 μm. (C) Quantification of oligomers shows significant decrease in the presence of AM 580 (Student\'s *t*-test, \*\*\**P* \< 0.001). (D) Expression of NEP in neuronal cultures; scale bar = 20 μm. (E) NEP activity in membrane lysates is significantly increased in Aβ1-42- (1 μ[m]{.smallcaps}, 3 days) treated cultures treated concomitantly with AM 580 (0.1 μ[m]{.smallcaps}, 3 days) compared


RARα signalling modulates key physiological mechanisms involved in Aβ clearance and how this signalling system is compromised by Aβ, which reduces the synthesis of the endogenous ligand RA. As RA and the RARα system have been implicated as one mechanism contributing to homeostatic synaptic plasticity (Aoto *et al*., [@b3]; Chen *et al*., [@b7]; Maghsoodi *et al*., [@b36]; Sarti *et al*., [@b53]), the question should be raised as to whether Aβ also participates in this regulatory mechanism, given that normally synaptic activity sets its extracellular level (Cirrito *et al*., [@b9]). There is evidence that endogenous Aβ has a number of physiological roles, including neuronal survival (Plant *et al*., [@b44]), modifying the expression of potassium channels (Plant *et al*., [@b45]) and of the probability of transmitter release (Abramov *et al*.,Q:

trying to install GCC

I would like to install gcc compiler by this command
apt install build-essential
and after pressing Yes, it asks me to insert some media.
Media change: please insert the disc labeled
 'Ubuntu 18.04.4 LTS _Bionic Beaver_ - Release amd64 (20200203.1)'
in the drive '/media/cdrom/' and press [Enter]
and this prompt repeats again and again
What's wrong?

A:

Edit /etc/apt/sources.list and put # in front of the line with cdrom
You need to be coneected to the internet to be able to install gcc.


(96,64,64)

BOMBCOLOR = (0,192,0)

SUBSTRATECOLOR = (128,128,0)

EXTINGUISHCOLOR = (128,128,255)

METHANECOLOR = (1,1,1)

SALTCOLOR = (255,255,255)

ACIDCOLOR = (192,255,0)

PANELCOLOR = (98,98,98)

PANELTEXTCOLOR = (255,255,248)

MSGCOLOR = (255,255,255)

#Element dots

BLANKCOLOR = (255,255,255)

SOLIDCOLOR = (0,192,0)

RESISTCOLOR = (128,0,128)

WATERCOLOR = (0,128,255)

FIRECOLOR = (255,128,0)

STEAMCOLOR = (174,174,174)

SMOKECOLOR = (96,96,96)

OILCOLOR = (0,12,0)

BOMBCOLOR = (0,255,128)

SUBSTRATECOLOR = (128,128,0)

EXTINGUISHCOLOR = (128,128,255)

METHANECOLOR = (204,204,204)

SALTCOLOR = (255,255,192)

ACIDCOLOR = (192,255,0)

PANELCOLOR = (192,192,255)

PANELTEXTCOLOR = (0,0,0)

MSGCOLOR = (0,0,0)

#Standard

BLANKCOLOR = (255,255,255)

SOLIDCOLOR = (255,0,255)

RESISTCOLOR = (128,0,128)

WATERCOLOR = (0,128,255)

FIRECOLOR = (255,128,0)

STEAMCOLOR = (174,174,174)

SMOKECOLOR = (96,96,96)

OILCOLOR = (96,64,64)

BOMBCOLOR = (0,192,0)

SUBSTRATECOLOR = (128,128,0)

EXTINGUISHCOLOR = (128,128,255)

METHANECOLOR = (192,192,192)

SALTCOLOR = (255,255,192)

ACIDCOLOR = (0,255,0)

PANELCOLOR = (164,164,164)

PANELTEXTCOLOR = (24,48,64)

MSGCOLOR = (24,48,64)

"""

LIQUIDCOLORS = ( SOLIDCOLOR , WATERCOLOR , OILCOLOR , BOMBCOLOR , SUBSTRATECOLOR , EXTINGUISHCOLOR )

FIRECOLORS = ( SOLIDCOLOR , WATERCOLOR , OILCOLOR , BOMBCOLOR , SUBSTRATECOLOR , EXTINGUISHCOLOR , FIRECOLOR )

#The width of the panel on the right

PANELWIDTH = 160

#A clocky ) )

f. add ( fire )

#Die out sometimes

if random . randint ( 0 , 100 ) > 70 :

self . kill ( )

return

#Kill if touching resist

elif screen. get_at ( ( self . x , self . y + 1 ) ) == RESISTCOLOR or screen. get_at ( ( self . x , self . y - 1 ) ) == RESISTCOLOR or screen. get_at ( ( self . x , self . y + 1 ) ) == EXTINGUISHCOLOR or screen. get_at ( ( self . x , self . y - 1 ) ) == EXTINGUISHCOLOR:

self . kill ( )

return

#Draw with FIRECOLOR

screen. set_at ( ( self . x , self . y ) , FIRECOLOR )

#A bomb dot

class BombDot ( pygame. sprite . Sprite ) :

def


. x = pos [ 0 ]

self . y = pos [ 1 ]

def update ( self ) :

#Remove the old pixel

screen. set_at ( ( self . x , self . y ) , BLANKCOLOR )

#Kill if it can go off the screen

if self . y > screen. get_height ( ) - 3 or self . y < 3 or self . x > screen. get_width ( ) - 4 or self . x < 4 :

self . kill ( )

return

#When to move up

if screen. get_at ( ( self . x , self . y - 1 ) ) == BLANKCOLOR or screen. get_at ( ( self . x , self . y - 1 ) ) == BOMBCOLOR or screen. get_at ( ( self . x ,-145 + 145. What is the nearest to -52 in a, -5, m?
-5
Suppose 34 = 4*s - 21*q + 16*q, 5*q + 89 = 9*s. Which is the nearest to 1?  (a) 2  (b) -1  (c) -3/7  (d) s
a
Let u = 0.12413 + 0.27587. What is the nearest to u in 0.5, 7, -0.3, -3/2?
0.5
Suppose 17 + 13 = -6*r. Which is the nearest to r?  (a) 5  (b) -0.1  (c) -10.1
b
Let q = -200.03 + 203.03. What is the nearest to 309 in q, 0.3, 8?
8
Let a = 10.97 - 0.39. Let n = a + -1.58. Let j = 0.4 - 0.8. What is the closest to n in 0, 1/4, j?
1/4
Let w = 4093 + -4098. What is


Victor Oladipo stands out for Magic in losing cause once more

Ken Hornack

FOX Sports

ORLANDO, Fla. -- A year ago at this time, Victor Oladipo was playing in games that rarely went longer than 40 minutes.

And he had yet to reach his sixth birthday the last time the Orlando Magic were involved in a contest that required three overtimes.

By both college and NBA rookie standards, you could say Oladipo played a game and a half Wednesday night. The authority with which he drove to the basket in the second and third quarters against the Chicago Bulls, who are ordinarily anything but slouches on defense, was a sight for sore eyes to fans who have seen the Magic struggle for victories.

Unfortunately for Oladipo, he is becoming something of an authority onthe upper end of the tubular during the expansion process, thereby resulting in an unsafe condition. Accordingly, operators typically stop upward progress of the expander before the upper end of the casing being expanded, then lower the expander in the well, then use a cutting tool to separate the uppermost portion of the tubular string which is not expanded from the portion of the tubular string which is expanded. Once the expander is removed from the well, the cut-off upper portion of the tubular string may be similarly removed from the well.
Various hydraulic expansion tools and methods have been proposed for expanding tubular while downhole. While some of these tools have met with success, a significant disadvantage to these tools is that, if a tool is unable to


concern for uncritical ingestion of mass art would be valid. Although Adorno may have overstated his concern, his desire for critical reflection of mass art appears to be well placed, and is a sentiment shared by Benjamin. As Miriam Hansen notes: Abandoning his defensive stance against the cinema as a mass media, Adorno can even conceive of a "liberated" film which would have to "extricate its a priori collectivity from the mechanisms of unconscious and irrational influence" and enlist it "in the service of emancipatory intentions." Benjamin would not have disagreed (1981, 192). Film, as a technological art form, can be viewed and understood by many people virtually on first contact (Carroll, 2004, 486-7) and can elicit powerful responses. The nature of these various responses is still underare not interested in the film for that, but rather for Chaplin's amazing antics. Here, I can only agree that Chaplin's comic riffs are an important source of our interest in Modern Times. But I would go on to point out that the humor of the sequence I have been discussing is intimately bound up with the thought that the human being is functioning as a machine, mechanically...As I see it, you cannot separate the film's serious thinking about alienation from its comic portrayal in order to deny that the film involves a philosophically significant contribution (2006, 30). Wartenberg claims that in order to understand the film and appreciate its humour, you are already thinking about the philosophical concepts of human and machine. Yet, the viewer may not


audiences. These stereotypes have imbedded values linked to ideological contexts. While there is room within the dominant capitalist ideology for diversity, capitalism seeks to remain dominant and therefore does not allow a great deal of diversity. As Adorno observes, the value of creative autonomy is the expression of diverse perspectives. This idea is summed up by Thomas Osborne who writes, "the idea of creative autonomy here is an ethical idea rather than a substantive notion: a regulative ideal rather than an accomplishable goal" (2008, 9). Adorno uses the word autonomy, Osborne claims, as a speculative notion as opposed to a concrete goal. This is to say that the word is not formally defined, yet advocates striving for autonomy and creative expression as opposed to uniformity. The more theweave of space and time: the unique appearance or semblance of distance, no matter how close it may be" (Benjamin, 1991-9, 518-9). Deleuze echoes this definition in the concepts of time and space on which he focuses his Cinema books written in the 1980s. Fredric Jameson calls attention to the dialectic occurring between Benjamin and Adorno, explaining, Riposting against Benjamin's attack on aesthetic 'aura' as a vestige of bourgeois culture and his celebration of the progressive function of technological reproducibility in art as the pathway to a new appropriation of it by the masses realized above all in the cinema, Adorno replied with a defence of avant-garde art and a counter-attack against over-confidence in commercial-popular art (Bloch et al, 1977, 106). For Adorno, the beauty of the work


Q:

Where is the django CMS history tab?

While editing pages in django CMS there is no history tab in the toolbar. Even on the django CMS official demo page there is no history tab in the toolbar. If this feature needs to be activated with some special setting, that setting is not in any documentation I could find.

A:

The History entry on the toolbar was removed as of django CMS 3.4.
This was because the revisions (history) implementation had a lot of shortcomings.
As an initial replacement, we're releasing a new app which allows users to undo/redo plugin operations and in the future we will extend this app to support revisions (restore).
Last, the Revert to live entry will come back in django CMS 3.4.2
Edit
Here's the djangocms-history app.

trying to improve small sensors. Only Google Pixel did a good job but even then...

Funny, but heise (the German magazine) stated that there is no real improvement so far. Only in the picture with 3 lux you can see a little bit more structure on the wooden plate. That´s all. This camera is 1:1 the camera of the Oppo R11s with the same marketing claim of four pixels mixed into one for the second sensor. Samples of this phone prove that there´s no better image quality.

Anonymous, 13 Nov 2017The second camera is likely a monochrome camera, otherwise it wouldn't make sense.The Exmor 376 is a tiny 1.0 μm RGB with 20mp. The secondary camera of OP 5T has the Exmor 376K. I haven't found anything about it, not


same estimating technique.

That’s just the nature of an estimate: you can try your best to get close to what will ultimately be the right value, but there will also be unknowns that require some judgment calls and lead to variability.

Estimating doesn’t require any magic. It’s the application of prediction and educated guessing based on imperfect and limited information. But the good news is, as time goes on, you’ll gather more information about your specific project and your estimates will have increased accuracy.

While you can hire a professional estimator to create your cost estimate, they will need detailed plans and specifications to base their estimate on. Most DIYers have a lot of their ideas stored in their heads, not on paper, and make many decisions on-the-fly. For this reason,in the Work Breakdown Structure) and nothing else. It’s a very clear relationship, ‘this pays for that’.

Indirect costs are those that are difficult to tie to one particular area or facet of the project. They are things that are used across time, across functions, etc.

Cost Matrix

In order to better conceptualize these two dimensions of costs and the four types of costs they contain, it’s helpful to view them in a 2×2 matrix. Within each of the four quadrants, we’ve included a couple of example costs to help you better understand each type.

Despite the rigid lines you see visually in the above graphic, try not to get too stuck on where any particular cost item is located. There are always project-specific issues that move things around and some costs


will straddle the lines between categories.

Instead, try to understand the bigger picture. The matrix makes it clear that different cost elements will impact the overall project in different ways. As you create new estimates and revise old ones, you can’t overlook any of the four quadrants.

Regardless of which of the estimating techniques you use (and don’t worry, we’ll explain three different options later in the article), you are not actually going to have line-item costs corresponding with any of the four cost categories above. Rather, these costs are implicitly included in the total cost of the project.

Our purpose here is to understand how costs work before we tackle where costs come from and what their value is. In the cost estimates themselves, we’ll break down the costs inin just a few sessions. Although I had the right idea to roll down the stop this time, it was right at where the bears would step back in, taking me out for a smaller profit that I probably should have gotten.

As far as positives, closing my USD/CAD short through a rolled stop turned out to be a positive move as the rally that came in Feb to close me at 1.2410 never really slowed down with the pair hitting 1.3100 mid-March.

Overall, sticking with the fundies for directional bias and being strict with my trade management yielded a positive result this time, but as always, I know I could have done better. Especially considering there were a few strong trends that persisted throughout the quarter like broad JPY


Texas Instruments Incorporated is offering developers a solution to the challenges posed by the Internet of Things (IoT) revolution with the company’s introduction of the SimpleLink Wi-Fi CC3000 module.

The IoT enables devices to be wirelessly connected to the home network and to the cloud. However, headless devices with no keypads or touchscreens including garage door openers, home appliances, lights, thermostats and treadmills can be complicated to connect to a Wi-Fi network.

The self-contained SimpleLink Wi-Fi CC3000 module features the SmartConfig technology, a Wi-Fi configuration process developed by TI that allows multiple in-home devices without displays to connect to a Wi-Fi network via a smartphone or tablet - in just one easy step. To see how simple SmartConfig technology is, watch the video here.

The CC3000 module now also supports serviceREG_PIDn(f->index), PIDn_ENP | PIDn_PID, PIDn_ENP | f->pid);
	else if (pluto->full_ts_users++ == 0)
		pluto_rw(pluto, REG_PIDn(0), PID0_NOFIL, PID0_NOFIL);

	return 0;
}

static int pluto_stop_feed(struct dvb_demux_feed *f)
{
	struct pluto *pluto = feed_to_pluto(f);

	/* disable PID filtering */
	if (--pluto->users == 0)
		pluto_rw(pluto, REG_PIDn(0), PID0_AFIL, PID0_AFIL);

	if ((f->pid < 0x2000) && (f->index < NHWFILTERS))
		pluto_rw(pluto, REG_PIDn(f->index), PIDn_ENP | PIDn_PID, 0x1fff);
	else if (--pluto->full_ts_users == 0)
		pluto_rw(pluto, REG_PIDn(0), PID0_NOFIL, 0);

	return 0;
}

static void pluto_dma_end(struct pluto *pluto, unsigned int nbpackets)
{
	/* synchronize the DMA transfer with the CPU
	 * first so that we see updated contents. */
	pci_dma_sync_single_for_cpu(pluto->pdev, pluto->dma_addr,
			TS_DMA_BYTES, PCI_DMA_FROMDEVICE);

	/* Workaround for broken hardware:
	 * [1] On startup NBPACKETS seems to contain an uninitialized value,
	 *     but no packets have been transfered.
	 * [2] Sometimes (actually very often) NBPACKETS stays at zero
	 *     although one packet has been transfered.
	 * [3] Sometimes


= (val >> 0) & 0xff;

	dev_info(&pluto->pdev->dev, "MAC %02x:%02x:%02x:%02x:%02x:%02x\n",
			mac[0], mac[1], mac[2], mac[3], mac[4], mac[5]);
}

static int __devinit pluto_read_serial(struct pluto *pluto)
{
	struct pci_dev *pdev = pluto->pdev;
	unsigned int i, j;
	u8 __iomem *cis;

	cis = pci_iomap(pdev, 1, 0);
	if (!cis)
		return -EIO;

	dev_info(&pdev->dev, "S/N ");

	for (i = 0xe0; i < 0x100; i += 4) {
		u32 val = readl(&cis[i]);
		for (j = 0; j < 32; j += 8) {
			if ((val & 0xff) == 0xff)
				goto out;
			printk("%c", val & 0xff);
			val >>= 8;
		}
	}
out:
	printk("\n");
	pci_iounmap(pdev, cis);

	return 0;
}

static int __devinit pluto2_probe(struct pci_dev *pdev,
				  const struct pci_device_id *ent)
{
	struct pluto *pluto;
	struct dvb_adapter *dvb_adapter;
	struct dvb_demux *dvbdemux;
	struct dmx_demux *dmx;
	int ret = -ENOMEM;

	pluto = kzalloc(sizeof(struct pluto), GFP_KERNEL);
	if (!pluto)
		goto out;

	pluto->pdev = pdev;

	ret = pci_enable_device(pdev);
	if (ret < 0)
		goto err_kfree;

	/* enable interrupts */
	pci_write_config_dword(pdev, 0x6c, 0x8000);

	ret = pci_set_dma_mask(pdev, DMA_32BIT_MASK);
	if (ret < 0)
		goto err_pci_disable_device;

	pci_set_master(pdev);

	ret = pci_request_regions(pdev, DRIVER_NAME);
	if (ret < 0)
		goto err_pci_disable_device;

	pluto->io_mem = pci_iomap(pdev, 0,end of the belt is inserted through the buckle and engaged by a camming toothed roller locking the belt in place with tension in the belt. To release such a buckle, the user pulls the free end of the belt with one hand, releases the locking roller with the other hand and by holding the locking roller in a position of disengagement with the belt webbing, the free end of the belt can be released from the buckle.
Another type of buckle is a side release buckle. The two halves of the buckle are each attached to a respective strap end. Separation of the buckle halves requires moving two release buttons toward one another with one hand and pulling the buckle halves apart with the other. This is also


for abuse or error. Some say laws are needed to protect the public.

In many instances, people have been unaware that the police around them are sweeping up information, and that has spawned controversy. Planes outfitted with cameras filmed protests and unrest in Baltimore and Ferguson, Mo. For years, dozens of departments used devices that can hoover up all cellphone data in an area without search warrants. Authorities in Oregon are facing an internal investigation after using social media-monitoring software to keep tabs on Black Lives Matter hashtags.

“This is something that’s been building since September 11,” said Jennifer Lynch, a senior staff attorney at the Electronic Frontier Foundation. “First funding went to the military to develop this technology, and now it has come back to domestic law enforcement. It’sbackward, said Matt Cagle, an attorney for the ACLU of Northern California.

“We think that whenever these surveillance technologies are on the table, there needs to be a meaningful debate,” Cagle said. “There needs to be safeguards and oversight.”

After the contentious hearing before the Fresno City Council on Beware, Dyer said he now wants to make changes to address residents’ concerns. The police chief said he is working with Intrado to turn off Beware’s color-coded rating system and possibly the social media monitoring.

“There’s a balancing act,” Dyer said.

An earlier version of this story incorrectly identified the nature of the probe Oregon authorities are facing for allegedly monitoring Black Lives Matter traffic on Twitter. It is an internal investigation.


FaceTime calls. You can now have an audio or video call with up to 31 other people. Whoever is talking will take center stage, but you can also use Focus View to pick a person to focus on if you prefer. You can launch group FaceTime right from a group Messages conversation.

group facetime

Group FaceTime calls feature all the same extra options for filters and effects and they’re encrypted just like one-to-one calls. They also work across iPhones and iPads, and can be answered on Apple Watches. This functionality is also coming to MacOS. It may be long overdue, but now that Apple is finally doing it, it seems to be doing it right.

Performance improvements

For anyone with an older iPhone, you may not be able to enjoy the newgovernment's student services and amenities fee, as well as fore-shadowing the idea of re-introducing caps on university places. The $273 annual student services fee was reintroduced by the Gillard government in 2011, after the Howard government abolished compulsory student fees in 2005. In an interview with Fairfax Media which was splashed on the Herald's front page on Wednesday, Pyne said the fee was ''compulsory student unionism by the back door'' and that the Coalition would abolish it. In another interview with The Australian Financial Review, he was asked when the fee might be abolished and he said: ''It might be in the budget, but that's not until May.'' But Pyne either went too far, or said too much.

This was not part of the script - Abbott had previously


Guild Wars 2 account using an e‑mail address and password that’s already on one of the lists.

Just finding a matching e-mail address and password generally isn’t good enough though. When the hacker tries to log in to the account, Guild Wars 2 recognizes that they’re logging in from a new location, and it sends an e-mail to the account holder to verify. But if the hacker can get someone’s Guild Wars 2 password from a list of known passwords, he can usually also get their e-mail account password from that list. Then he can just log in to the e-mail account and click through the verification email.

Using Unique Passwords

The simplest thing you can do to keep your Guild Wars 2 account secure—and all your other accounts too—is togoing to ask you to associate a phone number with your account. Don’t worry, we won’t spam you; we’ll use your phone number solely for the purpose of keeping your account secure.

Once you associate a phone number with your account, if someone tries to log in to your account from a new location, we’ll send an SMS to your cell phone or call your landline to verify that it’s you. And if you ever forget your password or lose access to your account, you’ll be able to ask us to send an SMS to your cell phone or call your landline to provide a code that you can use to reset your password. With one system, we can substantially improve both account security and account recovery.

SMS versus Authenticators

Some


    f = 0
                scores[file_name] = {}
                scores[file_name]['p'] = p
                scores[file_name]['r'] = r
                scores[file_name]['f'] = f

    with open(output_file, "a") as f:
        for file in scores:
            f.write(file + "_" + model_type + "_task2_precision: " + str(scores[file]['p']) + "\n")
       and writer of this film, where did the idea come from?

Well, I really wanted to explore a character who would normally be construed as the villain but also show you the banal ordinary side of their life to give you a different perspective of what you might think of a killer. I think no matter how violent a killer is, there’s probably a not very good reason of why they are like that. There’s an instinct in everyone and it comes out in certain people because of certain things and what’s so interesting about it is finding a character you felt sympathy for, have empathy for, but also were disgusted by and, as with real people, have the complexity of having all of those emotions in one. The


She was well received in a film which isn’t really something for mainstream audiences, yet she made it work. The fact that she co-wrote the film is equally impressive. Well, it seems she has a taste for blood as she stars in her directorial debut, Prevenge which sees a soon-to-be mother exact revenge on several individuals who have done her wrong. Her experience as a writer on Sightseers shines through in a dynamic and original way, coming up with more and more shocking ways to kill her victims.

She stars as Ruth who goes on a murderous rampage during the final weeks of her pregnancy. Her victims are completely clueless until their final moments; she’s charming, sweet, horny, polite and psychotic. All the while, being told to do awaymatter as Thrasher's counsel of record. This timely petition for a writ of mandamus followed.

Standard of Review
This Court has stated:
"`Mandamus is a drastic and extraordinary writ, to be issued only where there is (1) a clear legal right in the petitioner to the order sought; (2) an imperative duty upon the respondent to perform, accompanied by a refusal to do so; (3) the lack of another adequate remedy; and (4) properly invoked jurisdiction of the court.'"
Ex parte Perfection Siding, Inc., 882 So.2d 307, 309-10 (Ala.2003) (quoting Ex parte Integon Corp., 672 So.2d 497, 499 (Ala. 1995)). In reviewing a trial court's application of the law to undisputed facts, we *1216 apply a de novo standard of review. Ex parte J.E., 1 So.3d 1002, 1008 (Ala.2008).

Discussion
This Court set forth


knowledge of applicable limits do not exist. The suggested procedure seems unimpeachable under the circumstances, as well as being readily adaptable to other underinsured motorist claims."
Lowe, 521 So.2d at 1310. Thus, Lowe was not concerned with the issue whether the plaintiff's underinsured-motorist insurer would be permitted to pay for counsel other than, or in addition to, whatever counsel might otherwise represent the alleged tortfeasor.
Subsequently, however, in Driver v. National Security Fire & Casualty Co., 658 So.2d 390 (Ala.1995), this Court was concerned with such a situation. The Court in Driver held that an uninsured-motorist-insurance carrier could hire an attorney to represent an uninsured-motorist defendant, even after the carrier had opted out of the trial under the procedure described in Lowe, because of "the need for the uninsured motoristconsolidated with this case below.
[2]  Thrasher has not presented this Court with a statement of facts. Rather, Thrasher has expressly adopted the statement of facts presented by Littrell. Thrasher states in brief that it is irrelevant whether RLI is paying her legal fees and that that fact does not alter Taylor's obligations to Thrasher as her counsel.
[3]  The dissent states that it "cannot discern what concern it is of a plaintiff what counsel the alleged tortfeasor (and his or her liability carrier, where applicable) has chosen or agreed to (as has occurred here with respect to Taylor) or who pays counsel's fees." 73 So.3d at 1221. The plaintiff's concern, at least in this case, is the fact that the defendant RLI, who has chosen to opt


of Isaurian stock, but at the same time son-in-law of Leo, became sole Emperor, after a short co-reign with his own son Leo II (474). The "barbarian" origins of the Emperor caused antipathy towards Zeno among the people of Constantinople. Furthermore, the strong Germanic portion of the military, led by Theodoric Strabo, disliked the Isaurian officers that Leo I brought to reduce his dependency on the Ostrogoths. Finally, Zeno alienated his fellow Isaurian general Illus, who was bribed by Basiliscus. In the middle of the conspiracy was Verina, who fomented a popular revolt against the Emperor. The uprising, supported by Theodoric Strabo, Illus and Armatus, was successful, and Verina convinced the Emperor to leave the city. Zeno fled to his native lands, bringing with him some of thein part. Though American GDP has doubled in real terms over the last 25 years, median real income has grown by only 17 percent. While the richest 1 percent of the population has almost tripled its real income and the richest 0.01 percent has more than quintupled it, the bottom 10 percent has increased its income by only 12 percent. While in 1980, an average high school graduate earned 26 percent less than a college graduate, in 2005 this gap had grown to 38 percent. The blue-collar “Reagan Democrats” are among those struggling the most.

America’s transition to a service-based economy is one reason for its growing income inequality. A country specializing in manufacturing needs many high-quality (and well-paid) workers. By contrast, a service economy can succeed with a


percent of Americans declared themselves “angry” or “very angry” about the economic situation.

This anger is affecting political decision making. In September 2008, when Congress voted against the first version of the Paulson plan, it did so in response to the anger pervading the country. This past March, the House of Representatives approved a 90 percent tax on AIG bonuses for the same reason. And when President Obama contradicted his advisors and condemned the bonuses paid to Merrill Lynch executives, he, too, was responding to widespread anger. The question is not whether this populist pressure will have a strong influence on policy decisions, but how: Will it work to destroy, or to improve, the market system that has brought so much well-being?

If Republicans ignore popular anger, as the partyreceiver operating characteristic curve, which suggests that a drain hematocrit to blood hematocrit ratio of < or = 0.3 is strongly predictive that pericardial effusion would be absent or mild between the fifth and seventh postoperative days. It is safe to remove the chest tubes as soon as the macroscopic appearance of the drainage fluid turns to serosanguineous since this practically indicates cessation of active bleeding.


fly ball is being hit for an extra base-hit, BABIP does not affect him very much.

At home, he attempts to scale back the fly balls and tries to hit for more line drives and ground balls, which has resulted in a very high BABIP, but “only” a batting average of .294.

Conclusion

It’s very early, but Cruz has already shown that he not only is an established power-hitter, but also a real professional hitter that can adapt to his surroundings. He appears to know his limitations at Safeco Field and has been dominant on the road this season. Whether The Mighty Cruz can conquer the seemingly indomitable ballpark in Seattle remains to be seen, but it should prove to be a very fascinating adventure.to create values for us
one.to.ten <- 1:10 # create an object called one.to.ten that contains the all integiers between one and ten

In [9]:

# We can also do a lot of different functions with vector objects
max(our.ages) # find the maximum value in our.ages
min(our.ages) # find the minimum value in our.ages
sum(our.ages) # find the sum of all values in our.ages
mean(our.ages) # find the mean of all values in our.ages
median(our.ages) # find the median of all values in our.ages
range(our.ages) # find the range of all values in


‘Hairspray’ Cast Then and Now

‘Hairspray’

The musical “Hairspray” wowed Broadway in the summer 2002 and went on to win eight Tony Awards, including the top trophy for new musical. Based on the 1988 John Waters movie that starred a young Ricki Lake, the 1960s-set musical centers on zaftig teen Tracy, whose quest to appear on the “American Bandstand”-like “Corny Collins Show” introduces her to the civil rights movement. The musical version of “Hairspray” in turn inspired a 2007 movie adaptation directed by Adam Shankman before NBC chose to revive the show for its latest live musical telecast, “Hairspray Live!” Here’s a look at who’s played the biggest parts of “Hairspray” on Broadway, on the big screen, and now on TV.

Courtesy of NBC

Tracy Turnblad

Marissa Jaret Winokur/Nikki Blonsky/Maddie Baillio

Tracy is thepassed away in December 2016. ” Christopher Walken played opposite Travolta in the 2007 movie, while NBC has cannily tapped Martin Short to play the Turnblads’ loyal prankster.

Courtesy of REX/Shutterstock/NBC

Link Larkin

Matthew Morrison/Zac Efron/Garrett Clayton

Broadway’s original Link Larkin, the show’s teenage heartthrob, was a young actor named Matthew Morrison, who after major roles in Broadway’s “The Light in the Piazza” and “South Pacific” went on to play glee club director Will Schuester in six seasons of “Glee.” (In 2015 he returned to Broadway in “Finding Neverland.”) The movie musical cast real-life teen heartthrob Zac Efron, fresh off his breakout in the “High School Musical” franchise, to play Link, while Garrett Clayton, the dreamboat lead of another Disney Channel franchise, “Teen Beach Movie,” plays Link for NBC.

Courtesy of REX/Shutterstock/NBC

Motormouth Maybelle

Mary


Q:

What is the male equivalent of an alice band?

An "alice band" is so named, after the one worn by Alice in Lewis Carroll's stories.
Is there a male equivalent, to describe those worn by men with long hair (e.g. David Beckham)?

A:

No; it's still called an alice band, or sometimes the gender-neutral hairband or headband. They might also be referred to as sport(s) bands but that term is slightly misleading as it could equally apply to a wristband or similar.
I wouldn't be surprised to see the tabloid press coin a term like "Beckham-band", but there's not a common male equivalent in widespread use.

[Carbon budget of ecosystem in Changbai Mountain Natural Reserve].
The study used EPPML, a biological geochemistry cycle model that was built, to simulate the carbon budget for ecosystems in Changbai Mountain Natural Reserve. The results indicated that the annual net primary productivity [NPP (carbon)] of the natural reserve was 1.332 x 10(6) t.a-1. The annual NPP of mixed broad-leaved and Korean pine forest and spruce-fir forest were maximal, 0.540 x 10(6) t.a-1 and 0.428 x 10(6) t.a-1 respectively. The area and productivity of the two stands were maximal in Changbai Mountain, therefore, the simulating productivity of the two stands most greatly affect carbon cycle and carbon budget of the natural reserve, and the veracity of the former decides the security of the latter. To sum up, not only did


of the handy rule of encumbrance, a rule designed to make you do a lengthy and valuable form of pretend math while everyone else is waiting to go kill something. Who looks smart now? Not you murderers, no, the guy counting how much all of bat guano weighs is the cool guy!

In order to hold the group accountable, you must also exercise to maintain your encumbrance maximum in a realistic fashion. Meaning you must lift weights and do cardio approximately 6 hours a day.

Bonus encumbrance can be awarded to any creature who joins a local gym for 300 gp a month, but then these creatures cannot leave the immediate area and go on a vacation or “adventure” or they will lose their bonus. Because nobody actually uses hotelgyms when they’re travelling. Gross.

Everyone Gets Web

Also, web is always a cantrip.

It’s just too fun to use, and we were holding you back.

Don’t forget to set it on fire after you cast it on something.

Two Hair Options For Characters: Mullets Or Perms

We collected data on every type of haircut in all of our original illustrations over the years, and the only conclusion was clear. These are the only haircuts a hero could want.

Either your character has some kind of fantasy hair spray holding up an insane pile of hair, or they’ve got business in the front and a party in the back.

There are only two exceptions.

Werewolves can have one of these two types of haircut on top of their head and the other type elsewhere on their body.

Also


Coins Are Replaced With Diamonds

We’ve been playtesting and it turns out we nerfed long rests too hard.

So all cp, sp, gp, and pp are now replaced with fist-sized diamonds.

We don’t exactly have time to playtest this new balance but we feel pretty good about this one, because diamonds are nice to look at.

Look at the coins in the accompanying illustration.

Are they even coins? Too many shapes!

Diamonds will bring characters together, and force them to learn to mend clothes when the sharp edges of them shred all of their purses.

You First Have To Be Level 20 In Three Other Classes To Be A Bard

First Edition made it very clear that learning to become a singer-songwriter should be the most arduous, difficult, and unpleasant character choice a player could make.

Butof energy in the sense that it first transforms methane in an oxidative reaction to carbon monoxide, which in turn must be reduced to methanol. The direct selective transformation of methane to methanol is therefore a highly desirable goal and one that has been pursued by numerous researchers.
The main problem associated with the direct oxidation of methane to methanol is the unavoidable formation of byproducts including formaldehyde, formic acid, carbon monoxide, and the ultimate oxidation product, carbon dioxide. The challenge therefore has been to identify a catalyst that is highly selective for the formation of methanol. To date, such catalysts as molybdenum and vanadium oxides have been found to be the most effective but still fall short of industrial expectations.
Other applications of the present invention will become apparent


The pharmacokinetics of subcutaneously injected Bimosiamose disodium in healthy male volunteers.
Bimosiamose is a novel synthetic pan-selectin antagonist developed for the treatment of acute and chronic inflammatory disorders. Therefore the pharmacokinetics of Bimosiamose disodium were studied in healthy male volunteers after single and multiple subcutaneous injections. A randomized, double-blind, placebo-controlled dose escalation trial was carried out. The subjects received subcutaneous injections of placebo or 100, 200 or 300 mg Bimosiamose disodium into the abdomen. Plasma and urine concentrations of Bimosiamose were determined. The maximum plasma concentration was 2.17+/-0.70 microg/ml and the AUC(0-infinity) 11.1+/-2.9 h microg/ml after the highest dose on day 1 (mean+/-SD). For the apparent clearance CL/f 28.7+/-7.3 l/h and the terminal half life t(1/2) 3.7+/-0.6 h were calculated. The mean residence time MRT(infinity) of 5.5 to 6.3---
abstract: 'We perform two-dimensional hydrodynamical simulations of slowly rotating accretion flows in the region of $ 0.01-7\, \mathrm{pc} $ around a supermassive black holes with $ M_\mathrm{BH} = 10^{8} M_{\odot} $. The accretion flow is irradiated by the photons from the central active galactic nucleus (AGN). In addition to the direct radiation from the AGN, we have also included the “re-radiation”, i.e., the locally produced radiation by Thomson scattering, line and bremsstrahlung radiation. Compare to our previous work, we have improved the calculation of radiation force due to the Thomson scattering of X-ray photons from the central AGN. We find that this improvement can significantly increase the mass flux and velocity of outflow. We have compared the properties of outflow — including mass outflow rate, velocity, and kinetic


\ll r_\mathrm{min} $. We assume that the disc only emits optical/UV photons (i.e., $ L_\mathrm{d}  = L_\mathrm{UV} $), and the hot corona only emits X-ray, $ L_{*} = L_\mathrm{X} $. The total luminosity then includes both the luminosity of the disc and the corona, $L _\mathrm{acc} =L_\mathrm{d}+L_{*}$. Following KP09, we further assume that the extended disk radiation contributes to the radiation force due to both line force as well as electron scattering. Whereas, the corona radiation contributes to the radiation force only due to the electron scattering (line force contributions of the corona radiation has been ignored). We define the parameter $ f_{*} $ as the ratio of the corona luminosity to the total luminosity, $ L_{*} = f_{*} L_\mathrm{acc} $, and $ f_\mathrm{d}  = 11 (Chk1), respectively, even though an extensive communication exists between the two signaling avenues. Overall, the AMT-Chk2 and ATR-Chk1 pathways, together with the Wee1-like protein kinase (Wee1) that is activated by Chk1, are crucial for determining cell fate upon genotoxic injuries, being central in the G~1~-S, intra-S and G~2~-M cell cycle checkpoints^[@CR20],\ [@CR21]^.

Our previous results, both at the preclinical and clinical level, suggest that abnormal DDR activation is linked to suboptimal efficacy of chemotherapy^[@CR22]--[@CR25]^. Herein we hypothesized that over-activation of ATM-ATR-initiated signaling may configure a subset of MBC endowed with more aggressive molecular traits, assuming that this process reflects an underlying genetic portrait dominated by deregulated cell cycle control systems (e.g. *TP53* mutations) and elevated levels of oncogene-induced replication stress (e.g. *MYC* amplification)^[@CR26],\ [@CR27]^. To test this hypothesis,


γ-H2AX in three male breast cancer patients (**A**,**B**,**C**). Panels a--d show a sample with nuclear expression of pATR, pCHK1, pWEE1 and pRPA32 (**A**). Panels e--g show a sample with nuclear expression of pATM, pCHK2 and γ-H2AX (**B**). Panels h--l show a sample with nuclear expression of pATM, pCHK2 and pATR (**C**). Slide magnification ×40, inset magnification ×10. Scale bar 30 μm. Figure 3OncoPrint showing the associations between DDR-related biomarkers in male breast cancer. Statistically significant or borderline significant associations are reported.

DDR biomarkers and survival outcomes {#Sec4}
------------------------------------

Patients whose tumors expressed pATR (N = 63/112, 56.3%) had poorer survival outcomes compared with their negative counterparts (log rank p = 0.013, p = 0.007 and p = 0.010 for OS, 15- and 10-year survival, respectively, Fig. [4](#Fig4){ref-type="fig"} panel A). The combined expression of pATR and pChk2 (N = 21/112, 18.8%) was associated withsimilar adverse survival outcomes than pATR alone, with a trend toward statistical significance for 5-year survival (log rank p = 0.058, Fig. [4](#Fig4){ref-type="fig"} panel B). A model of triple-positivity (pATR/pChk2/pATM, N = 10/112, 8.9%) was fully significant also for 5-year survival (log rank p = 0.048), although the number of patients falling into this molecular group is limited (data available upon request).Figure 4Kaplan-Meier survival curves comparing (**A**) pATR-positive and pATR-negative cases, and (**B**) pATR/pChk2-positive and single-positive/double-negative tumors (N = 112).

Univariate Cox regression analyses (Table [2](#Tab2){ref-type="table"}) carried out for identifying factors impacting 10-year survival confirmed the adverse prognostic significance of pATR, pATR/pChk2 and pATR/pChk2/pATM (pATR: HR 2.71, 95% CI: 1.22--5.99, p = 0.014; pATR/pChk2: HR 2.67, 95% CI: 1.27--5.62, p = 0.010; pATR/pChk2/pATM: HR 3.76, 95% CI: 1.69--8.35, p = 0.001). Multivariate Cox regression models (Table [2](#Tab2){ref-type="table"}) generated by adjusting for other plausible predictors of the


I'll have you know) report illegal activities that are impacting and terrorizing us? Illegal activities that happen to be international offenses?

>>113122153Companies have scraped IPs and sent out DMCA notices for decades, it's nothing new. Just scare tactics.

>I actually expected to be able to illegally pirate and download media indefinitely

>I did not backup anything>I did not have ample storage onhand for this day

>I did not download anything I wanted to have

>I expected other people to provide for me for free, their content, and their bandwidth, indefinitely.

You have *ONLY* yourselves to blame

Maybe if you weren't such technologically incompetent retards who think that>using MadVR, usually from some shitty bloated codec pack, on microsoft windows>some edited cookies to get into a shitty "g.e-hentai plus cartoon cp" NSA botnet honeypot good goy sekritbe convenient now, but it's nothing we can use in the long term

What the fuck are you talking about? XDCC is 100% viable for the long-term. I've been doing it for years. It's better than torrenting in the first place since you can watching episodes as they download. The only time torrenting is better is for batches.

>>113123089Why does every naysayer say "IT'S GONNA MAKE THINGS WORSE". Like what the fuck you think is going to happen. A Fed having a bad day is going to be pissed he has to file your report in the morning so he sends the full fucking wrath of the Federal Government down on every person here?

So is this what Saint John and Jesus talked about? This new one world order that is


the utmost of evil and complete bullshit, where people turn on each other?

Is the internet going to be this final battle of who is who. Everyone who is against all this corporate shit for video games, celebrities, anime, whatever will be branded traitors of our apparently shitty overlords?

>>113122564Oh god, I'll see you guys in the slammerI couldn't give less of a shit, none of this will amount to anything. The most upsetting thing out of this is it reminded me that space brothers ended ;_;

>>113123309Try doing this on /b/ please. It's not like many will listen and even if they did you are making them risk getting shat on by not making a proper guide. You didn't even add the awareness of being behind several proxy services while                 echo '
'.img($na_1).'
';

                    echo '
';
                    echo         anchor(site_url('product/'.$prod_funct.'/'.$prod_list['id']),'
VIEW
');
                ?>


echo '
'.$prod_list['title'].'
';
                    echo form_close();
                ?>

        <?php endforeach; ?>

When i try to load the shop/add method im getting the following errors:
1)Trying to get property of non-object in my controller shop: line 40 and 41. That is theand I feel silly having to ask for help.

A:

You must add to line only first char from each inner array, then second etc.
for char in range(len(grid_list[0])):
    line = ""
    for i in range(len(grid_list)):
         line += grid_list[i][char]
    print(line)

This solution needs that all arrays inside must have same length.


add the key to 'completions'
        const keyAndAliases = [key].concat(aliases[key] || [])
        const notInArgs = keyAndAliases.every(val => args.indexOf(`--${val}`) === -1)
        if (notInArgs) {
          if (!zshShell) {
            completions.push(`--${key}`)
          } else {
            const desc = descs[key] || ''
            completions.push(`--${key.replace(/:/g, '\\:')}:${desc.replace('__yargsString__:', '')}`)
          }
        }
Indira Naik

Indira Naik is a Sufi and ghazal singer from Mumbai, India. She is classically trained in the Patiala Gayaki. She has been performing ghazals, bhajans and Sufi for more than 20 years in India and abroad. Sufism is an inspiration for her.

Early life
Indira was exposed to music at a very early age as her father is a Sarod and Sitar player and mother a Bharat Natyam guru.

Winning in her school singing competitions made her parents and herself take music seriously and Indira started training under Pt. Satyanarayan Singh of the Patiala gharana. Later Mohinderjeet Singh  train her voice. Over the years, she studied under Dayal Thakur and ghazals under the late Vithal Rao of Hyderabad.

Album releases
 Krishna Krishna - Bhajan album (1994)
 Run Jhun - Gujrati


RETURN

    -- check for overlaps in table 'INSERTED'
    IF EXISTS(
        SELECT hireId FROM your_table WHERE
             (INSERTED.onHireDate BETWEEN onHireDate AND offHireDate) OR
             (INSERTED.offHireDate BETWEEN onHireDate AND offHireDate)
    )
        BEGIN
           -- exception? or do nothing?
        END
    ELSE
        BEGIN
        END
END
GO

A:

Consider this query:
SELECT *
FROM Hire ASare discussed as they apply to the other two parties' liability.  Following our liability discussions, we turn to issues of damages.

A. Vernay's Liability

16
The district court found that Vernay breached certain express and implied warranties in the sale of the Vernatube to Young Brothers, all in violation of Me.Rev.Stat. Ann. tit. 11, §§ 2-313 (express warranty), 2-314 (implied warranty of merchantability), and 2-315 (implied warranty of fitness for a particular purpose), and that Vernay was also liable under theories of strict liability for product defects and negligence.  The district court arrived at its conclusions after making extensive findings regarding the Vernatube and the VPIS which were based both on trial testimony, exhibits entered into evidence and the parties' joint stipulations, dated June 1, 1994 ("Joint Stipulations").