swerves right into me." "I never saw it coming." "Ortho's coming down to set that broken ankle." "How's Paul?" "He's got a nasty burn on his hand thanks to you." " You're blaming me?" " You pushed his buttons." "He's like a little brother." "He had to prove you wrong." "And he almost got himself killed doing it." "Okay, Sid, anybody we should call?" "Boss, girlfriend, wife?" "Ex-wife." "God, no, unless you want to make her day." "Thank you." "Belly pain?" "Not from the accident." "It's my Crohn's flaring up." "Are you kidding me?" "You were driving high." "No way." "I'd never drive high." "Well, your tox screen says you tested positive for T.H.C." "Well, that was my Crohn's." "That flare up I was telling you about." "Ihere, please!" "Oh, no." "He's coding." " I can't..." "I can't..." "I can't bag him." " Okay, okay." "What's going on?" "His throat's closing up from soot inhalation." "I can't intubate with one hand." "If he burned his trachea, intubation wouldn't work anyway." "His pulse ox is down to 84." "I'll grab a crike kit." "Too risky." "He may be anticoagulated from Crohn's meds." "Heather, get me the fiber optic." "Paul, you're injured." "We got this." "Get me a 6.0 E.T. tube." "Come on, come on." "Come on, come on, come on." "All right, come on, guys." "Stats are dropping." "Move." "Okay, give me cricoid now." "Okay, come on." "Where?" "I see the cords." "Advancing the tube." "Okay." "Stats are coming up." "92%." "Nice save, Drew." "Yeah, should've


"So I don't feel like a coward for regretting to be here." "So, you wish you hadn't come?" " Yes, I do." " Right." "I mean, Ali, I want to save him, but I-I'm feeling guilty and stupid for leaving my family." "Aren't you?" "Yes." "But I came 'cause I wanted to help you." "I wish you would stop saying that." "It... it... it puts all this pressure on me." "What pressure?" "You're always reminding me that I-I saved you, I helped you." "That you would've killed yourself without me." "'Cause it's true." "Okay, but it makes me responsible for you." "I can't do that anymore, Tee." "I can't do that." "I-I have three kids that I have to take care of." "You don't have to take care"Inhalation therapist to pediatrics nurses station." "Inhalation therapist to pediatrics nurses station." "Hey, uh... is that the first sniper victim's wife?" "Yeah." "Yeah." "They were, uh..." "Married two weeks ago." "Postponed their honeymoon because of his job." "Supposed to be in Hawaii right now." " Hey, you..." "You okay?" " Yeah." "It's weird." "I... feel guilty about being upset." "Don't." "Telling the families is the hardest part of the job." "Does it ever get easier?" "I wish I could tell you yes." "Gwen!" " Fine." "I'm fine." " What the hell happened?" "Got called into a setup." "Son of a bitch coward shot Sara, blew our windshield out." "Okay, let's get Sara to C.T. and call it to the O.R." "I'm fine." "It's just my arm." "Hey." "


/*
Copyright (c) 2003-2006 Gino van den Bergen / Erwin Coumans  http://continuousphysics.com/Bullet/

This software is provided 'as-is', without any express or implied warranty.
In no event will the authors be held liable for any damages arising from the use of this software.
Permission is granted to anyone to use this software for any purpose,
including commercial applications, and to alter it and redistribute it freely,
subject to the following restrictions:

1. The origin of this software must not be misrepresented; you must not claim that you wrote the original software. If you use this software in a product, an acknowledgment in the product documentation would be appreciated but is not required.
2. Altered source versions must be plainly marked as such, and must not be misrepresented as being the original software.
3. This noticerhs)
	{
		mVec128 = rhs.mVec128;
	}

	// Assignment Operator
	SIMD_FORCE_INLINE btVector3&
	operator=(const btVector3& v)
	{
		mVec128 = v.mVec128;

		return *this;
	}
#endif // #if defined (BT_USE_SSE_IN_API) || defined (BT_USE_NEON)

/**@brief Add a vector to this one
 * @param The vector to add to this one */
	SIMD_FORCE_INLINE btVector3& operator+=(const btVector3& v)
	{
#if defined(BT_USE_SSE_IN_API) && defined (BT_USE_SSE)
		mVec128 = _mm_add_ps(mVec128, v.mVec128);
#elif defined(BT_USE_NEON)
		mVec128 = vaddq_f32(mVec128, v.mVec128);
#else
		m_floats[0] += v.m_floats[0];
		m_floats[1] += v.m_floats[1];
		m_floats[2] += v.m_floats[2];
#endif
		return *this;
	}

  /**@brief Subtract a vector from this one
   * @param The vector to subtract */
	SIMD_FORCE_INLINE btVector3& operator-=(const btVector3& v)
	{
#if defined(BT_USE_SSE_IN_API) && defined (BT_USE_SSE)
		mVec128 = _mm_sub_ps(mVec128, v.mVec128);
#elif defined(BT_USE_NEON)
		mVec128 = vsubq_f32(mVec128, v.mVec128);
#else
		m_floats[0] -= v.m_floats[0];
		m_floats[1] -= v.m_floats[1];
		m_floats[2] -= v.m_floats[2];
#endif
		return *this;
	}

  /**@brief Scale the vector
   * @param s Scale factor */
	SIMD_FORCE_INLINE btVector3& operator*=(const btScalar& s)
	{
#if defined(BT_USE_SSE_IN_API) && defined (BT_USE_SSE)
		__m128	vs =


= vcombine_f32(vext_f32(Tlow, vget_high_f32(mVec128), 1), Tlow);
		V = vcombine_f32(vext_f32(Vlow, vget_high_f32(v.mVec128), 1), Vlow);

		V = vmulq_f32(V, mVec128);
		T = vmulq_f32(T, v.mVec128);
		V = vsubq_f32(V, T);
		Vlow = vget_low_f32(V);
		// form (Y, Z, X, _);
		V = vcombine_f32(vext_f32(Vlow, vget_high_f32(V), 1), Vlow);
		V = (float32x4_t)vandq_s32((int32x4_t)V, btvFFF0Mask);

		return btVector3(V);
#else
		return btVector3(
			m_floats[1] * v.m_floats[2] - m_floats[2] * v.m_floats[1],
			m_floats[2] * v.m_floats[0] - m_floats[0] * v.m_floats[2],
			m_floats[0] * v.m_floats[1] - m_floats[1] * v.m_floats[0]);
#endif
	}

	SIMD_FORCE_INLINE btScalar triple(const btVector3& v1, const btVector3& v2) const
	{
#if defined BT_USE_SIMD_VECTOR3 && defined (BT_USE_SSE_IN_API) && defined (BT_USE_SSE)
		// cross:
		__m128 T = _mm_shuffle_ps(v1.mVec128, v1.mVec128, BT_SHUFFLE(1, 2, 0, 3));	//	(Y Z X 0)
		__m128 V = _mm_shuffle_ps(v2.mVec128, v2.mVec128, BT_SHUFFLE(1, 2, 0, 3));	//	(Y Z X 0)

		V = _mm_mul_ps(V, v1.mVec128);
		T = _mm_mul_ps(T, v2.mVec128);
		V = _mm_sub_ps(V, T);

		V = _mm_shuffle_ps(V, V, BT_SHUFFLE(1, 2, 0, 3));

		// dot:
		V = _mm_mul_ps(V, mVec128);
		__m128 z = _mm_movehl_ps(V, V);
		__m128 y = _mm_shuffle_ps(V, V, 0x55);
		V = _mm_add_ss(V, y);
		V = _mm_add_ss(V,btVector3& v2)
{
#if defined(BT_USE_SSE_IN_API) && defined (BT_USE_SSE)
	return btVector3(_mm_add_ps(v1.mVec128, v2.mVec128));
#elif defined(BT_USE_NEON)
	return btVector3(vaddq_f32(v1.mVec128, v2.mVec128));
#else
	return btVector3(
			v1.m_floats[0] + v2.m_floats[0],
			v1.m_floats[1] + v2.m_floats[1],
			v1.m_floats[2] + v2.m_floats[2]);
#endif
}

/**@brief Return the elementwise product of two vectors */
SIMD_FORCE_INLINE btVector3
operator*(const btVector3& v1, const btVector3& v2)
{
#if defined(BT_USE_SSE_IN_API) && defined (BT_USE_SSE)
	return btVector3(_mm_mul_ps(v1.mVec128, v2.mVec128));
#elif defined(BT_USE_NEON)
	return btVector3(vmulq_f32(v1.mVec128, v2.mVec128));
#else
	return btVector3(
			v1.m_floats[0] * v2.m_floats[0],
			v1.m_floats[1] * v2.m_floats[1],
			v1.m_floats[2] * v2.m_floats[2]);
#endif
}

/**@brief Return the difference between two vectors */
SIMD_FORCE_INLINE btVector3
operator-(const btVector3& v1, const btVector3& v2)
{
#if defined BT_USE_SIMD_VECTOR3 && (defined(BT_USE_SSE_IN_API)  && defined(BT_USE_SSE))

	//	without _mm_and_ps this code causes slowdown in Concave moving
	__m128 r = _mm_sub_ps(v1.mVec128, v2.mVec128);
	return btVector3(_mm_and_ps(r, btvFFF0fMask));
#elif defined(BT_USE_NEON)
	float32x4_t r = vsubq_f32(v1.mVec128, v2.mVec128);
	return btVector3((float32x4_t)vandq_s32((int32x4_t)r, btvFFF0Mask));
#else
	return btVector3(
			v1.m_floats[0] - v2.m_floats[0],
			v1.m_floats[1] - v2.m_floats[1],
			v1.m_floats[2] - v2.m_floats[2]);
#endif
}

/**@brief Return the negative of the vector */
SIMD_FORCE_INLINE btVector3
operator-(const btVector3& v)
{
#if defined BT_USE_SIMD_VECTOR3 && (defined(BT_USE_SSE_IN_API) && defined (BT_USE_SSE))
	__m128 r = _mm_xor_ps(v.mVec128, btvMzeroMask);
	return


mice ([Supplementary Fig. 2D](#SD1){ref-type="supplementary-material"}), and the dialysates collected were quantified using the liquid chromatography--mass spectrometry (LC-MS) method^[@R42]^. As expected, GhBChE mice exhibited a much faster cocaine clearance ([Fig. 2E](#F2){ref-type="fig"}) and less extracellular DA ([Fig. 2F](#F2){ref-type="fig"}) in the NAc than those in WT mice. Consistently, LC-MS analysis demonstrated a significantly faster clearance of BE (benzoylecgonine), a major cocaine metabolite, in the plasma of GhBChE animals ([Supplementary Fig. 2E](#SD1){ref-type="supplementary-material"}). Engineered hBChE has very low activity for acetylcholine^[@R14]^. We did not detect significant differences in plasma acetylcholine levels in GBChE and control mice ([Supplementary Fig. 2F](#SD1){ref-type="supplementary-material"}). To further assess the pharmacodynamics property of cocaine in GhBChE mice, we monitored acute cocaine-induced locomotor behavior. Both GhBChE and GWT mice exhibited dose-response relationships, as measured by distance traveled and stereotypic counts, after cocainethe mice with engraftment of *hBChE*-expressing cells had significantly levels of human BChE in the blood, whose expression was stable for more than 8 weeks *in vivo* ([Fig. 4G](#F4){ref-type="fig"}). Our results suggest the potential clinical relevance of cutaneous gene delivery for treatment of cocaine abuse and overdose in the future.

Discussion {#S6}
==========

Our study demonstrates that transplantation of genome-edited skin stem cells can be used to deliver an active cocaine hydrolase long-term *in vivo.* Skin epidermal stem cells can be successfully employed for *ex vivo* gene therapy, as efficient genetic manipulation is possible with minimal risk of tumorigenesis or other adverse events *in vivo*^[@R31],[@R32]^. Skin transplantation protocols, including procedures based on the use of human epidermal stem cells to generate cultured epidermal autografts (CEAs), have been in clinical use for


cells^[@R57]^. Our skin transplantation model built with WT isogenic animals provides a unique approach to examine this process *in vivo.* Skin epidermal keratinocytes have low immunogenicity^[@R30]^. In skin, Langerhans cells are the only cell type expressesing *MHC* class II for antigen presentation^[@R30]^, as epidermal keratinocytes are considered as 'non-professional' antigen-presenting cells. Transplanted skin tissues generated from epidermal stem cells are devoid of Langerhans cells or other leukocytes with antigen presentation capabilities; therefore, the risk of antigenicity is significantly reduced. Consequently, engineered skin grafts are generally well taken and immunologically tolerated in WT isogenic animals^[@R20]--[@R22]^. Indeed, skin-derived expression of *hBChE* in host mice with intact immune systems can be stable for more than 10 weeks without significant decrease in the serum level of engineered enzyme, strongly suggesting that thein addition of PI solution at a final concentration of 25ng/µl. After staining, the cells were analyzed immediately using flow cytometer BD FACSCanto™ II (BD Biosciences, San Jose, CA) with an excitation wavelength at 488 nm and emission at 585 nm. DNA content and histograms of cell cycle distribution were analyzed using FlowJo software, version 10 (FLOWJO LLC, OR).

Protein biochemical analysis {#S12}
----------------------------

Western blotting was performed as described previously ^[@R61]^. Briefly, equal amounts of the cell lysates were separated on a SDS-polyacrylamide gel electrophoresis (PAGE) and electroblotted onto a NC membrane. The immunoblot was incubated with Odyssey blocking buffer (Li-Cor) at room temperature for 1 h, followed by an overnight incubation with primary antibody. Blots were washed three times with Tween 20/Tris-buffered saline (TBST) and incubated with a 1:10000


HCl and Methamphetamine HCl (Sigma-Aldrich, Saint Louis, MO) were dissolved in sterile saline and delivered intraperitoneally at appropriates doses in a volume of 10 ml/kg. Ethanol (Sigma-Aldrich, Saint Louis, MO, 95%, density=0.816) was prepared in 20% (v/v) diluted in sterile saline and delivered intraperitoneally at appropriate doses. Vehicle (sterile saline) was intraperitoneally administered at 10 ml/kg as a control.

### Microdialysis: {#S15}

GhBChE and GWT mice were anesthetized with isofluorane and placed in a flat skull position in a Kopf stereotaxic frame. Guide cannula was secured with dental cement on mouse skulls above the NAc using the anterior-posterior +1.2 mm, medial-lateral 1.0 mm coordinates and dorsal-ventral −5.0 mm from bregma. 24 h after implantation, a microdialysis probe (2 mm dialyzing membrane, CMA-7, Harvard Apparatus, Cambridge, MA) was inserted in toused a method by *Wong* et al^[@R42]^. Derivatized dialysate samples were analyzed by LC--MS using Agilent 1290 UHPLC coupled to a 6460 triple quadrupole mass spectrometer (Santa Clara, CA) in multiple reaction monitoring (MRM) mode. Five μLof samples were injected onto an InfinityLab Porshell 120EC-C18 (2.1 mm×100 mm, 4 μm, 100 Å pore size). Samples were analyzed in triplicate. Electrospray ionization was used in positive mode. Automated peak integration was performed using Agilent MassHunter Workstation Quantitative Analysis for QQQ. All peaks were visually inspected to ensure proper integration.

### Acetylcholine (Ach) Assay: {#S17}

The base line level of Ach in GhBChE and GWT mice blood serum was quantified using QuickDetect™ Acetylcholine (Mouse) ELISA kit. Standard curve was generated using known concentrations of mouse Ach standard and its corresponding OD value.


2013). Each chamber had a unique combination of visual and tactile properties (one large chamber had black walls and a rod floor, the other larger chamber had white walls with a mesh floor, whereas the middle chamber had gray walls and a solid gray floor). Each compartment had a light embedded in a clear, Plexiglas hinged lid. Time spent in each chamber was measure via photobeam breaks and recorded. CPP was determined on testing days via time spent in the drug-paired side minus time spent in the saline-paired side.

### Acquisition of CPP: {#S20}

We used a biased CPP procedure similar to that from a previous study in our laboratory (Yan et al, 2013). Acquisition of CPP consisted of three sequential procedures---pretest, conditioning and test. After 7--12 days of recoveryQ:

how are chips and ics build

I want to know what is the process and how are chips and ics manufactured which are used on motherboards of computer systems is there some good tutorial available for same so that i can try building one at home

A:

Most likely it's not happening. To properly build a working chip you need a clean room. These are very expensive to build and maintain. You'll also need a bunch of expensive tools:

Induction Furnaces
"Wet Bench" for doing stuff with chemical etching
Photo lithography equipment
Deposition machines (CVD, PVD, sputtering, etc.)
Physical etching equipment (Reactive Ion etching, etc.)
Testing/verification equipment
Packaging equipment

...
The list could go on and on. The clean room at my local university (not that great, but decent for MEMS type work) cost several thousands of dollars a year


would more accurately be referred to as the ministry of illness.^[@r03],[@r04]^ Social epidemiology is science that supports the new public health movement^[@r05]^ and encourages interdisciplinary approaches that move outside the borders of conventional health promotion in search of effective interventions.

Research design is guided by theoretical models of the causes of the causes, and these models can be split into 2 contrasting groups. Materialist models emphasize income, employment, housing, and other "concrete" factors. Their strength is measurability. In contrast, psychosocial models seek explanations for social differences in health and well-being by studying social, family, and working relationships as well as beliefs and emotions. The strength of this level of explanation is that it may lead to a detailed understanding of the human experience of health and health inequality. Manybeen paid little attention, and the measure has not been applied by social epidemiologists in Japan to assess health inequalities.

With respect to social stratification, international comparison must be built on shared concepts and methods. In contrast, some health determinants would best be studied with culturally specific tools.^[@r34],[@r35]^ Mental health is a particularly important dimension of health. The conventional, Western approach has proved to have weaknesses and thus a new understanding would be welcomed. Medication has long been the first-line treatment for depression in Europe and North America. However, it has been suspected for many years that drug treatment does not lead to improved outcomes except among those suffering from major and chronic depression. A recent expert review by the UK National Institute of Clinical Research confirmed this view


of East Asian countries may improve on models developed in the United Kingdom, for example, in their explanatory power for social inequalities in health outcomes. This is not to suggest that there is some mystical Oriental secret to health and longevity, but rather that the whole picture of East--West differences in social inequalities in health will not be captured if we favor Occidental constructs of psychosocial factors, well-being, and social position when such constructs are subject to major cultural and philosophical influences. Drawing on existing research models and methods is practical and has been productive during the first phase of social epidemiology in East Asia. Development of newly validated measures of social determinants inspired by East Asian researchers will surely be important for East and West in theDanish officials have ended an investigation into an outbreak of E. coli that affected almost 40 people, but they are continuing to look at a Salmonella monophasic Typhimurium outbreak that has sickened almost 50 people.

For the E. coli outbreak, it was not possible to find the source of infection, officials report, but there was a suspected link to beef salami. In late 2018, Statens Serum Institut (SSI), the Danish Veterinary and Food Administration (Fødevarestyrelsen) and the National Food Institute jointly investigated the outbreak.

A total of 38 people, including 31 children younger than five years old, were infected with a specific type of Shiga toxin-producing E. coli (STEC) with the serotype O26:H11 from August to November 2018. Young children are one of the groups at higher risk of severe


for how pretty it is. A tree has tilted inward right at the top mouth of the cenote, its roots cascading dramatically into the cave from above.

In the morning, light fliters into the cenote in a clear, defined shaft, illuminating the water a soft blue.

Refreshed, we packed up our stuff and headed north again, to Merida, by bus. That night, we enjoyed our second Revolution Parade of the day -- this one quite a bit larger, though almost completely consisting of high schools, colleges and other educational organizations in the area. Some schools dressed up in traditional Mayan dress, some dressed as Mexican Revolutionaries (complete with "rifles" slung on the back for the men and "babies" bundled onto the backs of women) and others just wore their schoolthe weed at 4pm that day and it was still in his system at 12 midnight. “If the Gardai stopped you three days later, the weed would still be in your system. If it was alcohol it would be gone.”

He also said that “in the long term, cannabis destroys the brain cells.

Mr Powderly said that his client, who was said to earn €350 per week, had no previous convictions

After considering the evidence, including the issue of the handcuffs, Judge Zaidan opted to convict Mr Byrne.


Why School Holidays Infringe Consumer Rights

18/08/2011 14:43 BST
|
Updated
17/10/2011 10:12 BST

We broke the back of it folks. Us teachers are officially over half way through our summer holiday. For some of us we have just two weeks left of rest and relaxation. Some of us have already been into school a number of times this holiday. Most of us went into school to watch our graduating students collect their A Level and will do the same again next week for the GCSE results. My point is, teacher's are 'sold' the profession with holidays in mind. However, if school holidays were shoes we would return them as faulty.

Before I continue, I want to apologise to anyone who isn't in the teaching profession for stumbling upon this post. It's written bylevels in the small intestines of mice fed the plant-based diet (daily dietary MIR2911 intake 10 pmoles) were more than a 100-fold higher than those of mice gavage fed a single 400 pmole dose of the synthetic MIR2911 ([Fig. 5](#f5){ref-type="fig"}). MIR168a, a miRNA present in both plant-based diets and chow, was detected in the small intestines at a level 100-fold lower than that of MIR2911 ([Fig. 5](#f5){ref-type="fig"}). Together, these results substantiate that MIR2911, especially MIR2911 derived from plants, is more stable than other plant-based miRNAs.

Uptake of plant-derived MIR2911 vs synthetic MIR2911
----------------------------------------------------

Stability of plant-derived MIR2911 in cabbage extracts was greater than that of the synthetic MIR2911 ([Fig. 3](#f3){ref-type="fig"}); however does this translate into improved bioavailability? To test this, we sought to compare and contrast uptake efficiency of MIR2911 in these two


of popular vegetables ([Table 1](#t1){ref-type="table"}). This plant-derived small RNA delivered by typical dietary ingestion had a digestive robustness that appears to help make it more bioavailable compared to other miRNAs ([Figs 3](#f3){ref-type="fig"} and [4](#f4){ref-type="fig"}). In milk, specific miRNAs appear to be encapsulated in exosomes conferring protection against degradation and facilitating uptake[@b18][@b19]. We hypothesize that a plant specific protein can facilitate uptake as well as enhancing stability during digestion. Our results implicate modification of the MIR2911 complex during consumer uptake. During digestion or absorption, the proteinase K-sensitive cabbage complex ([Fig. 2](#f2){ref-type="fig"}) is transformed into a serum-stable proteinase K-resistant complex ([Fig. 6](#f6){ref-type="fig"}). We speculate this protein "shield" of MIR2911may be modified in transit, possibly within intestinal epithelial cells. It remains an open question whether the plant binding protein is completelyof Service) Regulations, 1960 was framed by the State of Bihar in exercise of the powers conferred by Article 318 of the Constitution of India and in supersession of the Regulation published with the Appointment Department's notification no. A-2654 dated 31 March 1953. Under Rule 3 of the Regulations, 1960 the Commission was constituted with a Chairman and 10 (ten) other members. The strength of members was reduced to 6 (six) after bifurcation of the State of Bihar and the State of Jharkhand vide notification no. 7/PSC-1013/95 (Part-3) Per 8262 dated 9 October 2002 of the Personnel & Administrative Reforms Department, Bihar.

The Mandate of Bihar Public Service Commission.
Article 320 and 321 of the Constitution of India prescribes the mandate of the State Public Service Commissions, which are:
a)Recruitment by


breathe?" "Just when you thought they couldn't get any faster or furiouser." "Bam, there it is." "Faster!" "And furiouser!" "This is amazing!" "Tonight, action movies and drinking." "Tomorrow, batting cages and drinking." "The day after that..." "Drinking and drinking." "This is amazing." "I'm living the dream." "Wait, doesn't your dream include your husband?" "Yeah, sure." "But first we have our fun, then me and Graham have our fun, if you know what I mean." "Man-on-man scrabble?" "♪ Beautiful dreamer, awake unto me ♪" "Hello, men!" "Nelson," "I love your husband." "And we are watching a movie." "We just went to this public-domain karaoke contest." "Listen, listen." "They call it "Kara-hokey"." "You and Graham did karaoke?" " That's kind of weird." " Why is that weird?" "You hate karaoke.""No, I do, and I'm glad you guys went, but it's kind of our thing..." "Our thing that I hate, but still our thing." "My thing is watching Vin Diesel try to act and drive at the same time." "Spoiler alert:" "He can't." "So, how did he ask you to go to karaoke?" "Well, he texted me this morning, and he told me to bring my singing shoes, and I did, and we did, and it was awesome." "Oh, that's Graham's ring." "Oh, you and Graham have a ring now?" "Well, you know, me and Graham have a ring too." "It's on our fingers!" "Guys," "Vin Diesel just tried to cry." "Spoiler alert:" "He cannot." "Oh, he is so funny." "You gotta see this cat gif he sent


stake out Graham and Abby and destroy their beautiful little platonic friendship." " Thanks for the advice, Beckett." " Wait." "No, no, no, no, no." "I don't want credit for this!" "I cannot believe I let that press release go out without reading it." " Oh, don't blame yourself, dad." " I don't." "I never do." "That's the fun of being me." "I can fix this." "I just need to find my lucky bra." "I don't know where the hell she put it!" "Sweetie." "Sweetie, please, stop, stop, stop." "All this stuff about your lucky bra, it's crazy." "Super crazy." "Court-order-committed crazy." "I just need you to buckle down and do the work necessary to solve this problem, all right?" "Without the aid of a lucky bra orIntroduction {#Sec1}
============

Recent sequencing of DNA to identify polymorphisms has catalyzed the quest for protein kinase "driver" mutations, which contribute to the transformation of a normal cell to a proliferating cancerous cell. On the other hand, kinase "passenger" mutations are considered to reflect mutations that merely build up in the course of cancerous cell replication and proliferation. At present, there are driver mutations in nonsmall cell lung cancer (NSCLC), such as *epidermal growth factor receptor* (*EGFR*) mutations \[[@CR1]--[@CR3]\], a fusion gene between echinoderm microtubule-associated protein-like 4 (*EML4*) and the anaplastic lymphoma kinase (*ALK*) \[[@CR4], [@CR5]\], and fusion genes with RET proto-oncogene (*RET*) \[[@CR6]--[@CR8]\], for which specific agents have been developed. In this manuscript, a road to personalized therapy by *EGFR* mutations in advanced NSCLC, which was the first experience


treating NSCLC patients individually, there have been two streams of clinical studies. Clinical efficacy of EGFR-TKIs such as gefitinib or erlotinib has been investigated initially in unselected patients \[[@CR9]--[@CR13]\] and, subsequently, on the basis of clinical characteristics \[[@CR14]\]. On the other hand, in order to develop personalized therapy in NSCLC, clinical efficacy of EGFR-TKIs has been indicated by molecular selection in phase 3 trials of NSCLC (Table [1](#Tab1){ref-type="table"}) \[[@CR15]--[@CR19]\].Table 1Clinical studies using EGFR-TKISecond-line treatmentFirst-line treatmentUnselected patientsBR.21ISELINTERESTV-15-32Selection by backgroundIPASSSelection by EGFR mutationNEJ Gefitinib Study-02WJTOG 3405OPTIMAL (CTONG 0802)EURTAC-SLCG GECP06/01

Unselected patients {#Sec3}
-------------------

In the BR.21 phase III comparative study \[[@CR9]\], 731 previously treated NSCLC patients (unselected by *EGFR* mutations) were allocated randomly to the erlotinib or placebo groups at a ratio of 2:1. At the primary endpoints, erlotinib was significantly superior in termshad significantly longer PFS compared with the cisplatin plus docetaxel goup, with a median PFS of 9.2 months vs. 6.3 months (HR 0.489, *p* \< 0.0001) \[[@CR17]\]. In order to evaluate erlotinib further, the phase III OPTIMAL study \[[@CR18]\] was initiated in August 2008. It compared the PFS of erlotinib with gemcitabine plus CBDCA in the first-line treatment of Chinese patients with advanced *EGFR* mutation-positive NSCLC. The median PFS was significantly longer in erlotinib-treated patients than in those on chemotherapy (13.1 vs. 4.6 months; HR = 0.16; *p* \< 0.0001). In another phase III study, EURTAC \[[@CR19]\], started in February 2007, PFS with erlotinib was compared with standard chemotherapy for first-line treatment of European patients with advanced *EGFR* mutation-positive NSCLC. The preplanned interim analysis showed that the median PFS was 9 . 7 months in the erlotinib group, compared with


/*
 * Licensed to the Apache Software Foundation (ASF) under one
 * or more contributor license agreements.  See the NOTICE file
 * distributed with this work for additional information
 * regarding copyright ownership.  The ASF licenses this file
 * to you under the Apache License, Version 2.0 (the
 * "License"); you may not use this file except in compliance
 * with the License.  You may obtain a copy of the License at
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 * http://www.apache.org/licenses/LICENSE-2.0
 *
 * Unless required by applicable law or agreed to in writing, software
 * distributed under the License is distributed on an "AS IS" BASIS,
 * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 * See the License for the specific language governing permissions and
 * limitations
            return LiteralExpression.newConstant(null, type);
        }

        List<Expression> children = keyExpression.getChildren();
        List<Expression> values = Lists.newArrayListWithExpectedSize(children.size());
        for (Expression child : children) {
            PDataType type = child.getDataType();
            child.reset();
            if (child.evaluate(tuple, ptr)) {


and addiction are “naturally linked” and Purdue Pharma should consider becoming an “end-to-end pain provider,” providing opioids to treat pain, and then offering suboxone to treat addiction.

The documents noted the large increase in opioid addiction over the prior five years and said opioid addiction “can happen to any-one.” Sackler wrote that the market for addiction treatment was attractive due to “large unmet need for vulnerable, underserved and stigmatized patient population suffering from substance abuse, dependence and addiction.”

Healey wrote in her brief, “The Tango team mapped how patients could get addicted to opioids through prescription opioid analgesics such as Purdue’s OxyContin or heroin, and then become consumers of the new company’s suboxone.”

Although that proposal was dropped, company officials again discussed profiting off addiction in June 2016, this time by2014). The latter, verbal type of mental imagery is ubiquitous in silent reading and obviously relevant to print-to-audio remediation. In fact, the listener's inability to freely imagine the voices of characters and narrators has been highlighted by some critics as a key argument against the audiobook medium (Rubery 2011b). However, as the present chapter focuses on the similarities rather than differences between audiobook and print, I accept this first level of reduction, constraining the recipient's mental imagery to the referential domain. Secondly, mental imagery at large, including mental imagery in reading, is frequently reduced to visual imagery alone (Connell and Lynott 2012). Mental imagery in other sensory modalities – whether exteroceptive (e.g., touch, hearing, smell, taste), interoceptive (e.g., pain), proprioceptive (e.g., balance), or kinesthetic (e.g., acceleration) – is


the same contents, on the other hand, makes the imager partly adopt the embodied stance of the two adventurous eaters. Compared to mere visual pictures, such enactive imagery has an ampler sensory range. An enactive image of David and Catherine enjoying their breakfast, for instance, would likely enlist the modalities of taste and smell (in relation to the food), touch and movement (in relation to the manual handling of the food), or at least a subset of these. Evidence from neuroimaging, behavioural, and self-report experiments, suggests that mental imagery is grounded in actual sensory and motor physiological processes.Verbally induced flavour images, comprising taste and smell (Eardley and Pring 2011), as well as verbally induced motor representations, comprising touch and movement (Fischer and Zwaan 2008), have been found toactivate corresponding areas of the brain and to interfere with overt activity in respective modalities (e.g., sucking candy, rotating a knob). Even if the visual component of the reader's image were not overridden by these other modalities, it would certainly not amount to a finite picture or movie snippet. It would rather resemble the fragmentary sight of a three-dimensional set of objects inviting bodily interaction. 3.3. First Set of Consequences for Text Experience Now that the recipient's mental imagery has been redefined in terms of enactment, what does the redefinition mean for the intuition that audiobooks prompt more mental imagery than print? Firstly, the visual stimuli in print decoding consist invariably in flat monochrome signs on a page, having little in common with the multimodal sensations (Spence and


changing reading environments in a longer time frame. A research team led by literary scholar Andrew Elfenbein collected an extensive set of reading memories written down between 1777 and 1915. Looking into what aspects of people's reading experiences were typically mentioned upon long-term recall, Elfenbein's analysis (2012) revealed that detailed recollections of reading environment were strongly represented, and consistently correlated with memories of story content. More anecdotally, novelist Marcel Proust went so far as to claim that books read in the more distant past were above all the chronicles of our physical, mundane life and "of the places and days when and where we engaged" (Proust 2011, 18) in reading them. Such accounts of print reading diverge from the intuition that print reading, unlike audiobook listening, is notAnne, and Don Kuiken. 2014. "Lost in an iPad: Narrative Engagement on Paper and Tablet." Scientific Study of Literature 4.2: 150–177. Miall, David S. 2006. Literary Reading: Empirical & Theoretical Studies. New York: Peter Lang. Murphy Paul, Annie. 2013. "The New Marshmallow Test: Resisting the Temptations of the Web." The Hechinger Report (3 May). http://hechingerreport.org/content/the-new-marshmallow-test-resisting-the-temptations-of-the-web_11941 (18 November 2014). Oatley, Keith. 2011. Such Stuff as Dreams: The Psychology of Fiction. Chichester: Wiley-Blackwell. Perry, Menakhem. 1979. "Literary Dynamics: How the Order of a Text Creates Its Meanings [With an Analysis of Faulkner's "Rose for Emily"]." Poetics Today 1.1–2: 35–64. Proust, Marcel. 2011. On Reading. Trans. Damion Searls. London: Hesperus Press. Reber, Rolf, Norbert Schwarz, and Piotr Winkielman. 2004. "Processing Fluency and Aesthetic Pleasure: Is Beauty in the Perceiver's Processing Experience?"


the car’s focal point. Precision-cast aluminum suspension components and 19-inch Goodyear tires – combined with the overwhelming presence of the V-8 engine – create a striking appearance and communicate the performance credentials of the Ford GT.

The 5.4L powerplant is all-aluminum and fed by an Eaton screw-type supercharger. It features four-valve cylinder heads and forged components, including the crankshaft, H-beam connecting rods and aluminum pistons. The resulting power output is 500 horsepower and 500 foot-pounds of torque.

The power is put to the road through a Ricardo six-speed manual transaxle featuring a helical limited-slip differential.

Race History
The original Ford GT racers were engineering and design marvels demonstrating Ford’s dedication and perseverance. In a few short years under the direction of Henry Ford II, the company built a program from scratch thatthe Ford GT40 concept car shown at the 2002 North American International Auto Show, the Ford GT engineering team is doing most of its work “under the skin.”

“The first step in creating a world-class supercar is creating a stiff structure,” says Huibert Mees, chassis supervisor on the Ford GT program. Mees set contradictory targets for the chassis: extremely high torsional stiffness for unparalleled body control, yet efficient use of materials, necessary for a lightweight chassis to reach performance and handling targets.

The team developed an all-aluminum space frame, comprising 35 extrusions, seven complex castings, two semi-solid formed castings, and various stamped aluminum panels. The structure has two unique features: A large center tunnel to house the mid-mounted fuel tank and cut-out roof sections for the cantilevered doors.

“Using CAD/CAM and


him. “We’ve managed to build a world-class supercar on a race team schedule,” he says. “As they say in motorsports, ‘The other teams won’t wait for you at the starting line.’”

Brembo one-piece brake calipers with four pistons each grab cross-drilled, vented discs at all four wheels. The discs are a massive 14 inches in front and 13.2 inches in the rear, for fade-free stopping power. Anti-lock control and electronic brake force distribution help provide consistent, straight braking even from very high speeds.

One-piece BBS wheels are wrapped by Goodyear Eagle F1 Supercar tires, size 235/45ZR-18 in front and 315/40ZR-19 in the rear.

Supercharged 5.4-liter V-8
The Ford GT is driven by an all-new, mid-engined powertrain producing 500 horsepower and 500 foot-pounds of torque. The engine architecture comes from Ford’s MOD engineRicardo. The clean-sheet design enabled Ford engineers to tailor the individual ratios to their specifications, without being forced to select from an existing assortment. The transmission is fully synchronized and features an integral, torque-sensing, limited-slip differential.

Digitally-mastered Interior
To maximize passenger comfort, Ford GT chief designer – Camilo Pardo – and the engineering team made extensive use of a virtual-reality computer-modeling device called the digital occupant buck. The device is a revolutionary step in CAD/CAM technology with a virtual re-creation of the interior surfaces translated from the CAD data; a physical mock-up of the seat, steering wheel and pedal assembly; and a test engineer fitted with magnetic sensors, which manipulate a virtual person inserted in the digital interior. “The real advantage of digital occupant is that it allows engineers to


the program was approved, Ressler assumed the role of con******t to the Ford GT team, identifying and recruiting the best engineers within Ford Motor Company and bringing years of real-world experience to the team. In addition, he serves as a liaison between the team and upper management.

Ressler joined Ford in 1967 as a senior research scientist and became principal design engineer for suspension and steering in 1971. Between 1981 and 1994, Ressler served as chief components engineer for the Climate Control Division, chief engineer of Small Car Design and Development, chief engineer of Chassis and Electrical Engineering and executive director of vehicle engineering, Car Product Development.

Ressler was elected a Ford vice president in 1994 as head of Core Product Development, Ford Automotive Operations and became head of AdvancedNRL Axuz Search - NRL History

Souths History
Souths are arguably the most famous of all rugby league clubs and from the first season of first grade rugby league they have set the standard by which others were measured. A 1908 foundation club, the Rabbitohs have fielded rugby league legend after rugby league legend in their famous cardinal red and myrtle green hoops. EntryID - 480

St George History
After the St George District Rugby League Football Club was formed at a meeting at Rockdale Town Hall in 1908, but failed to develop due to lack of numbers who were willing to sign up, St George made its official entrance into rugby league in 1921. Rugby League's birth in the Illawarra began back in 1910, when meetings at the old Terminus Hotel


and advocate the merits of one pathway over another, but it is not the case that Europe cannot deliver its electricity demand from renewable electricity if it so chooses.

Even if it were correct that Europe could satisfy all or most of its electricity demands by 2050 using renewables (and from all the reading i have done i dont believe it is possible) the cost of renewables would be totally unacceptable to the population at large. In any case why risk worsening climate change by gambling on the possiblity that renewables might work when there is already a proven and cheaper option, nuclear power. Nuclear power can simultaneously meet our future electricity demand and CO2 reduction with the added bonus of Gen 4 (e.g.IFR) power plants being able to1. Technical Field
The embodiments herein generally relates to a method of processing seismic data and particularly to a method of processing a multi-component marine seismic data. The embodiments herein more particularly relates to a method of processing a multi-component marine seismic data in order to estimate the properties of the seafloor and sensor calibration filters in a shallow water environment.
2. Description of the Related Art
The marine surveys can also be conducted using the sensors attached to an Ocean Bottom Cable (OBC) laid out on an ocean bottom rather than in towed streamers. Due to the operational limitations, most of these types of surveys are conducted in the water bodies with depths less than 70 meters. However OBC crews in recent years have acquired 3D surveys in depths up


and businesses that contributed toward raising about $215,000 from this years walk. The top fundraising team was Samaritan, at $21,414, and the top community team was the Newman Family, which raised $14,510.

A Friend of Heart Volunteer Award recipient will not be announced until tonight, but the following already know they will receive recognition:

nBrody Beckwith and Donna Kinney, who will receive the Inspirational Honoree Award. Ms. Smorol said Mrs. Kinney got her blood pressure checked at a heart walk, and it ended up saving her life. Brody, 3, was in congestive heart failure and has had surgery. He will be scheduled for another operation before he enters kindergarten.

n Jill Edwards, who will receive the Lifestyle Change Award for having made significant positive changes in life.

The reception is sponsored by
Ask HN: Help us to improve our product by providing feedback - itsquiz
Hi, guys! We're developing the AI-based automatic quiz creator https://itsquiz.ai/. The website generates tests on any topic without manual work, will be useful for teachers, e-learners, recruiters. It's on beta-testing now and we'll be happy to hear your feedback.
P.S. Subscribe to mailing list to get notified of the launch
======
brudgers
People cannot provide feedback on something that has not launched.

~~~
itsquiz
Thank you for your answer. Here is the demo version
[http://demo.itsquiz.ai/](http://demo.itsquiz.ai/) where you can try to create
tests

~~~
brudgers
Neat. The demo link might make a good 'Show HN' so long as it meets the
guidelines.

Show HN guidelines:
[https://news.ycombinator.com/showhn.html](https://news.ycombinator.com/showhn.html)

~~~
itsquiz
Thanks!Submitted just now)


itr(k, m+1);
                })
            }
            else itr(k, m+1);
        })(key, 0);
    }
    if (callback)
    {
        callback(null);
    }
}

where potholeCoordinates is an Object of Arrays of PotholeData
getRoadCoordinates() simply looks like this:
/* snaps the coordinates to the nearest road
 * Parameters:
 *  • coords : coordinates object`
 * Returns:
 *  • coordinates, snapped to road
 * NOTE: the points you're looking for are accessiblevia the snappedPoints member of the returned object (in done() or success())
 */
function getRoadCoordinates(coords)
{
    return $.ajax({
        type: 'get',
        url : 'https://roads.googleapis.com/v1/snapToRoads',
        data: {
            key : API_KEY,
            interpolate : true,
            path : coords.lat + ', ' + coords.lng
        }
     });
}

...and the async.waterfall() is like this:
async.waterfall([//fetchServerPotholeData,  // for some reason, this function is not receiving data


that I want to be acknowledged for my accomplishments as a (fill in the blank: lawyer, athlete, marksman, business person, etc.), not because I am a female version of any of those titles. I yearn for a society that acknowledges merit over identity.

The late Dick Faegler summed it up best when he said “equality of opportunity is freedom, but equality of outcome is repression.” This ideal is not relegated to conservative circles; indeed, many of our most respected American leaders of change have trumpeted the same sentiment. For example, Martin Luther King Jr. spoke of a “dream of equality of opportunity,” and Franklin D. Roosevelt said that “equality of individual ability has never existed and never will, but we do insist that equality of opportunity still must beThis text, by one of the major figures of sociological analysis, confirms what many suspect, that the ruling élite presents a lower level of morality compared to the ruled population. This is substantiated by the fact that, generally, the ruling groups have committed and still commit, on percentage, more crimes than the rest of the population. Only when strong limits are introduced to their power, the ruling élites reduce their level of criminality. Sorokin's and Lunden's analysis and data confirm also Lord Acton's conviction that "power corrupts, and absolute power corrupts absolutely".

Chapter II

MORALITY AND MENTALITY OF RULERS

The results of our empirical study of moral behaviour and mentality of rulers and governments may be summed up in five generalizations. None of these pretends to be an exact, universal. or


behaviour of ruling groups tends to be more criminal and sub-moral than that of the ruled strata of the same society.

4. The greater, more absolute, and coercive the power of rulers, political leaders, and big executives of business, labour and other organizations, and the less freely this power is approved by the ruled population, the more corrupt and criminal such ruling groups and executives tend to be.

5. With a progressive limitation of their power, criminality of rulers and executives tends to decrease qualitatively (by becoming less grave and murderous) and quantitatively (by decreasing the rate of criminal actions). If and when the power of ruling bodies is greatly limited (legally and factually). and when the governments function amidst a strongly integrated and unified moral public opinion, their criminalitymay become equal or even fall below the criminality of their ruled populations.

2. FACTORS RESPONSIBLE FOR THESE CHARACTERISTICS

The nature of the ruling occupation and social selection are probably the main factors of these typical traits of ruling elite. This can be deduced from a careful analysis of the forms of social selection of rulers and the kind of activities contained in the business of ruling, including the focal social position of the magnates of power and the environment in which governing activities are carried on. This means that the five typical features of ruling groups are not so much an expression of rulers' personal wishes and fancies, but that these wishes, fancies, and characteristics are moulded and impressed into their mentality and behaviour by their occupational activities and


by the kind of social selection of rulers prevailing in their societies or nations. Of course, the factors of biological heredity and marginal free choice also play some role, but this role finds its actual manifestation exactly through the mechanism of social selection and through their occupational functions. Therefore, these additional factors are taken into consideration and included among the factors responsible for the characteristics discussed. Let us now briefly comment on them.

3. MORAL DUALISM OF RULING ACTIVITIES

Viewed from a moral standpoint, ruling functions consist of two profoundly different, even strikingly opposite, activities; some tend to morally ennoble rulers while others stimulate their demoralization and criminality.

Ennobling Activities of Rulers . There is no doubt that the occupational functions of rulers contain several morally ennobling activities such as: theV and Phillip II of Spain, Louis XIV, Henry VIII, Elizabeth I, Nero, Diocletian, Constantine the Great, Asoka, and by most monarchs, dictators, commanders. inquisitors, etc. In a milder form this moral schizophrenia also marks the high ranks of democratic government personnel: political and military leaders, top executives of big corporations, labour leaders, and even the hierarchy of vast religious and scientific organizations.

In regard to the business executives the dualism is once more confirmed by the recent study of 162 American business executives by E. E. Jennings and associates of Michigan State University's Business Administration College. The study shows that “the typical executive is apt to lead a double life with one set of principles for the office, another for home and church .... A Jekyll-and-Hyde strain runs


at the beginning of chapter II, give tentative answers to these questions. In their essentials these answers contend that when measured by the same stick, the moral behaviour of ruling groups tends to be more criminal than that of the ruled population in the same society; and that with a progressive limitation of the power of rulers and executives their criminality tends to decrease in frequency as well as in gravity of crimes committed. This analysis of criminalizing factors of rulers and bosses of vast organizations gives deductive reasons for these generalizations, derived from the analysis of the nature of the ruling occupation and from the prevalent forms of social selection. Now these deductive conclusions must be tested and confirmed empirically through a study of the factual criminalitythe Ten and the Thirty Tyrants in Ancient Greece, Marius and Sulla, Caesar and Antony, Crassus and Augustus in Rome, Cromwell and Robespierre, Mussolini and Hitler, Lenin and Stalin, and many of today's dictators or revolutionaries in Europe, Asia, Latin America, and elsewhere, the crime-record is still worse than that of the legitimate, autocratic monarchs.

Of the 34 Turkish sultans, from Osman (1290-1326) up to Mahomet VI (1918-1922), at least 14 sultans or some 41 per cent were guilty of direct or indirect murders of their relatives, close friends, and associates. But here again, with a partly factual and partly lega1 limitation of their power, the last five sultans, beginning with Abdul Mejid (1839-1861) and ending with Mahomet VI (1918-1922) seem to have been free from this form of


a window to soldiers of the guard the severed dripping head of their master." (Charles Diehl, Byzantium: Greatness and Decline, 1957)

Hardly less than 50 per cent of the Byzantine rulers were murderers of their relatives, close friends, and associates.

No better is the record of the Arabian dynasties. A fratricidal struggle for power started immediately after the death of the founder of Mohammedanism, and all four of "the Orthodox Caliphs" (632-661) were guilty of the crime discussed. If all the rulers of the subsequent dynasties of the Umayhads (661-750) and of the Abbasids (750-1100), before and after the dismemberment of the Caliphate into several dynasties were not guilty, then at least some 45-50 per cent committed it in various forms.

If from the Arabian rulers we turn to those offratricidal wars of the emperors, shoguns and other rulers). Perhaps it is typical that out of some 15 Shoguns of the Tokugawa period (1603-1867), at least four or some 26 per cent were guilty of murder of their relatives, close friends and associates. All in all, some 25 to 30 per cent of the rulers of Japan seem to have committed this crime.

Out of twelve Inca kings, (from Manco Capac to Huascar), at least nine, or 75 per cent, are guilty of these crimes.

If in a similar way we study the rates of crimes committed by rulers of other states or empires - China, India, Babylon, Ancient Egypt, and so on - the main results would be similar to the rough percentages given. The percentages for different dynasties


of the United States). More specifically in the United States, in 1956, there was about one murderer per 20,000 and about one manslaughterer per 28,571 urban population.

Though with a decrease in murder-criminality of the constitutionally and factually limited governments the democratic governmental groups may not necessarily be more criminal than the common population, such groups are still as criminal (in these crimes) and possibly even more criminal than the total (ruled) population. The United States gives an example of this situation. As mentioned, in 1956, in our urban population there was about one murderer per 20,000 and one manslaughterer per 28,571 urban population. Now, in order to have 20,000 and 28,571 high governmental persons in the United States we shall take: all the presidents and vice-presidents of theinvestors remain confident of their future profitability despite a current challenging economic environment.

How do our investment managers find quality companies?

Choosing a good quality company is a bit like finding a good quality car to buy. When you set out to buy a new car, you usually want something reliable that’s going to drive smoothly, perform well and stand the test of time. Selecting a company to invest in is no different. Our investment managers want to be confident that the company will still be operating in many years to come, that profits (or performance) during that time will be good, and that few things will go wrong along the way.

To help identify the right car, you may look at a brochure from the car dealer. This will include


Q:

Array not inserting Data Correctly in Java/Android

Here is a method I have:
 public double getCombinedAprThisMonth() {
    Cursor c = database.rawQuery("SELECT *  FROM debt;", null);
    double totalMonthlyFee = 0;
    double SingleAprRate = 0;
    double[] storeFees;
    int rows = c.getCount();
    storeFees = new double[c.getCount()];

    for (c.moveToFirst(); !c.isAfterLast(); c.moveToNext()) {
        for (int i = 0; i < rows; i++) {
            String BalColumn = c.getString(c
                    .getColumnIndex("debt_total"));
       be more specific. Looking at the commons set there are definitely things that are very useful. I guess I'm talking more about things like the Jakarta Lang package which are similar to the Java Gems project in scope.

I guess I'm talking more about things like the Jakarta Lang package which are similar to the Java Gems project in scope.

Yes you are right. Lang seems useful but most of the time I use 0.1% of it. For example I now use it just for its ClassUtils.getShortClassName(). And being a 256kb jar, it makes perfect sense to copy/paste this method inside my codebase.

TechTarget provides technology professionals with the information they need to perform their jobs - from developing strategy, to making cost-effective purchase decisions and managing their organizations technology projects


scripts to verify the spender is allowed to spend the
   coins
 - Insert the block into the block database

## Examples

* [ProcessBlock Example](https://pkg.go.dev/github.com/decred/dcrd/blockchain/v3#example-BlockChain.ProcessBlock)
  Demonstrates how to create a new chain instance and use ProcessBlock to
  attempt to add a block to the chain.  This example intentionally
  attempts to insert a duplicate genesis block to illustrate how an invalid
  block is handled.

## License

Package blockchain is licensed under the [copyfree](http://copyfree.org) ISC
License.
shots in before the ref could grab me,” Casey said. “I was definitely hyped about that and just very happy.”

In the co-main event, Alan Jouban and Ricky Legere Jr. engaged in an entertaining, back-and-forth welterweight battle before Jouban pulled out a split-decision victory.

The judges scored it 28-29, 29-28, 29-28 for the Los Angeles fighter.

“Alan showed a lot of heart and same with Ricky Legere, man,” RFA president Ed Soares said. “Both those guys to me, that was a great fight. That could be up for Fight of the Night for sure.”

The second round might have been the best five minutes of the entire night. Legere found his way to Jouban’s back and sunk in a neck crank before switching to full mount. After delivering some punishment, Legere returned


quickly to end the fight at 1:14 of the second round.

“I knew I had stunned him earlier in the round but I didn’t want to waste my energy. I didn’t want to really force the knockout too much,” Moontasri said. “I knew if I stayed patient, I knew that eventually I was going to be able to time him. It’s just something I’ve trained for thousands and thousands of times in the gym.”

Rinaldi was out for several minutes and eventually came to and was communicating with the medical staff, but was strapped to a stretcher and taken to an ambulance. Soares said he didn’t know where Rinaldi was taken or his condition.

Joseph Rinaldi tweeted that his brother was awake and had a possible concussion, then updated it tosetShadowSize(float shadowSize, float maxShadowSize) {
        if (shadowSize < 0f) {
            throw new IllegalArgumentException("Invalid shadow size " + shadowSize +
                    ". Must be >= 0");
        }
        if (maxShadowSize < 0f) {
            throw new IllegalArgumentException("Invalid max shadow size " + maxShadowSize +
                    ". Must be >= 0");


Exit polls in India have not always had the best track record. In many elections, only one of the many pollsters has gotten it right - and the problem is that it's usually a different pollster each time. And recent world history is rife with occasions on which the polls have simply gotten it wrong - consider the Australian elections this week, in which the governing centre-right alliance proved every single poll for months wrong to crawl back into power.

That said, pollsters are more likely to be wrong when the vote share margins are close. That's when sampling error and so on can creep in and make a significant difference when multiplied across seats and states. Can we really argue that this is the case with the 2019exit polls?

The exit polls are predicting a comfortable win for the NDA (Numbers in this table are based on exit poll of polls data at 10 pm)

I would argue that in many parts of the country, it looks like the margins are too wide for such an error. In particular, in the north, centre and west, outside Uttar Pradesh and one or two other states, it's hard to argue with the trends that almost all the opinion polls have shown. Modi rules this part of India, and his grip on voters' hearts (and their voting fingers) seems unbreakable at this point. If I were Modi, and these numbers are replicated on 23 May, I would be asking myself: do I have another five years or another 10?

That said,


The people at Parks Canada who are in charge of the budget for The MOTHERWELL HOMESTEAD N.H.S are planning on moving to self guided tours next year due to budget cuts. There are plans on eliminating the working horse program, where the land is farmed with horse drawn equipment the way it was done 100 years ago. This is the way we built this country, and without programs like this, all the effort and hardwork that was put forth by our predecessors could very easily be taken for granted and forgotten. These programs, and the people who run them, serve not only as a reminder of past years/struggles, but also as motivation and education for many generations to come.

For more information on the Motherwell Homestead National Historic Site,couple of dozen uses when 3D printing in ABS.

After reaching the limits of ABS, I switched to a plastic called Alloy 910. It took some time to figure out the best way to print with the new material and finalize the design that worked best with it. But Alloy 910 is less brittle than ABS which means that it can be used many more times without permanently deforming and losing the springiness which is necessary for a snug fit. The success on the left can be used more than fifty times and still work well.

I will now be able to make these end caps myself instead of ordering them. In addition to being cheaper, they are much higher quality. The injection molded end caps I was using before


#!/usr/bin/env python

# Modified Horovod MNIST example

import os
import sys
import time

import horovod.tensorflow as hvd
import numpy as np
import tensorflow as tf
import graphics
from utils import ResultLogger

learn = tf.contrib.learn

# Surpress verbose warnings
os.environ['TF_CPP_MIN_LOG_LEVEL'] = '3'

def _print(*args, **kwargs):
    if hvd.rank() == 0:
        print(*args, **kwargs)

def init_visualizations(hps, model, logdir):

    def sample_batch(y, eps):
        n_batch = hps.local_batch_train
        xs = []
        for i in range(int(np.ceil(len(eps) / n_batch))):
            xs.append(model.sample(
                y[i*n_batch:i*n_batch + n_batch], eps[i*n_batch:i*n_batch + n_batch]))
       # Images seen wrt anchor resolution
            n_processed += hvd.size() * hps.n_batch_train
            # Actual images seen at current resolution
            n_images += hvd.size() * hps.local_batch_train

        train_results = np.mean(np.asarray(train_results), axis=0)

        dtrain = time.time() - t
        ips = (hps.train_its * hvd.size() * hps.local_batch_train) / dtrain
        train_time += dtrain

        if hvd.rank() == 0:


Spotify is being taken to court in the U.K. by the dance music record label the Ministry Of Sound London for copyright violation. The allegation is a surprising one, because it suggests the Ministry Of Sound’s IP is being violated by playlists in Spotify . Spotify ‘s playlists are said to be clones of the track lists from the record label’s highly successful dance albums.

The label says it has demanded Spotify take the playlists down repeatedly since 2012, but has seen no response. The suit asks that Spotify delete the playlists and block other playlists that copy the albums in the future, as well as pay damages and costs.

The complication here is that the Ministry of Sounds albums are aggregations of other people’s IP by the label’s ownturn it on there’s nothing left to do," T-Mobile tells us. "It’s a one-time opt in." After that, the company clarified that there is no throttling or de-prioritization of video for these customers, and the change will remain intact until a user disables it. The company also confirmed that this doesn't just apply to HD (780p, 1080p) content, but 4K video streaming as well. "The HD video will be at whatever resolution the content provider pushes out," confirmed T-Mobile. "If they have the HD option turned on and the video is 4K then it will stream 4K," the company added. In other words, video appears to no longer be de-prioritized whatsoever, a welcome shift from T-Mobile's past policies. In other words, video appears to no longer be de-prioritized


whatsoever, a welcome shift from T-Mobile's past policies.

News Jump Are The Comcast-Charter X1 Talks Dead In The Water?; AT&T May Offer Phone Plans With Ads For Discounts; + more news Europe's Top Court: Net Neutrality Rules Bar Zero Rating; ViacomCBS To Rebrand CBS All Access As Paramount+; + more news Verizon To Buy Reseller TracFone For $7B; 5G Not The Competitive Threat To Cable Many Thought It Would Be; + more news MS.Wants Records From AT&T On $300M Project; Google Fiber Outages In Austin, Houston, Other Texan Cities; + more news States With The Biggest Decreases In Speed; AT&T Hopes You'll Forget Its Fight Against Accurate Maps; + more news AT&T's CEO Has A Familiar $olution To US Broadband Woes; EarthLink Files Suit Against Charter; + more newslen(buf) > 0 {
		_p0 = &buf[0]
	}
	_, e1 := callgetcwd(uintptr(unsafe.Pointer(_p0)), len(buf))
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func accept(s int, rsa *RawSockaddrAny, addrlen *_Socklen) (fd int, err error) {
	r0, e1 := callaccept(s, uintptr(unsafe.Pointer(rsa)), uintptr(unsafe.Pointer(addrlen)))
	fd = int(r0)
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func getdirent(fd int, buf []byte) (n int, err error) {
	var _p0 *byte
	if len(buf) > 0 {
		_p0 = &buf[0]
	}
	r0, e1 := callgetdirent(fd, uintptr(unsafe.Pointer(_p0)), len(buf))
	n = int(r0)
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func wait4(pid Pid_t, status *_C_int, options int, rusage *Rusage) (wpid Pid_t, err error) {
	r0, e1 := callwait4(int(pid), uintptr(unsafe.Pointer(status)), options, uintptr(unsafe.Pointer(rusage)))
	wpid


0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func Umask(mask int) (oldmask int) {
	r0, _ := callumask(mask)
	oldmask = int(r0)
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func Uname(buf *Utsname) (err error) {
	_, e1 := calluname(uintptr(unsafe.Pointer(buf)))
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func Unlink(path string) (err error) {
	var _p0 *byte
	_p0, err = BytePtrFromString(path)
	if err != nil {
		return
	}
	_, e1 := callunlink(uintptr(unsafe.Pointer(_p0)))
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func Unlinkat(dirfd int, path string, flags int) (err error) {
	var _p0 *byte
	_p0, err = BytePtrFromString(path)
	if err != nil {
		return
	}
	_, e1 := callunlinkat(dirfd, uintptr(unsafe.Pointer(_p0)), flags)
	if e1 !=0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func Ustat(dev int, ubuf *Ustat_t) (err error) {
	_, e1 := callustat(dev, uintptr(unsafe.Pointer(ubuf)))
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func write(fd int, p []byte) (n int, err error) {
	var _p0 *byte
	if len(p) > 0 {
		_p0 = &p[0]
	}
	r0, e1 := callwrite(fd, uintptr(unsafe.Pointer(_p0)), len(p))
	n = int(r0)
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func readlen(fd int, p *byte, np int) (n int, err error) {
	r0, e1 := callread(fd, uintptr(unsafe.Pointer(p)), np)
	n = int(r0)
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func writelen(fd


flags int, fd int, offset int64) (xaddr uintptr, err error) {
	r0, e1 := callmmap64(addr, length, prot, flags, fd, offset)
	xaddr = uintptr(r0)
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}
got past the problem, then again I doubt they’d really care that much.

the quality difference of live (for this) must be pretty big like how I thought HD was not that much better than SD until I saw a movie in HD or show. I wonder how good the virtual transparent screens work out (in quality)?


the interior-architecturing of sol-gel-based ZnO nanostructure for enhanced electrical conductivity via stepwise fabrication process. Stepwise combined method of NIL process with wet etching and hydrothermal growth was applied for the interior-architecturing. Interior low crystalline regions and organic residuals resulting from low-temperature calcinations were removed, and the resultant structural voids filled up with newly growing ZnO nanocrystalline. Figure [1](#F1){ref-type="fig"} shows the stepwise fabrication procedure, which is composed of three steps: nanopatterning ZnO film (step 1), wet etching for removal of the residual layer (step 2), and the additional growth of ZnO (step 3). Thermally annealed line-patterned ZnO film was fabricated using direct ultraviolet-NIL (UV-NIL) and thermal annealing (Figure [1](#F1){ref-type="fig"}a,b,c,d). During wet etching, the residual layer was removed and ordered arrays of individually separated ZnO nanolines were formed (Figure [1](#F1){ref-type="fig"}e). For the additionalZnO was grown from the TA nanolines to form nanorod(NR)-agglomerated nanolines. Nanorods grew out of line along the TA nanoline like the leaves of a palm tree (Figure [2](#F2){ref-type="fig"}d). The results indicate that ZnO was grown in the \<001 \> direction and the overall length of the out-of-line nanorods were around 200 nm.

![**SEM images of the fabricated ZnO nanostructures.** SEM Images after **(a)** nanopatterning of ZnO film (step 1), **(b)** wet etching (step 2), and **(c, d)** additional growth of ZnO at 75°C (c) and 90°C (d) on SiO~2~/Si substrate.](1556-276X-9-428-2){#F2}

When line-nanopatterned ZnO film was processed to hydrothermal growth at 90°C of step 3 without the wet-etching process of step 2, it appeared that nanorods grew and were buried under the residual layer (Additional file [1](#S1){ref-type="supplementary-material"}: Figure S1). We thus presume that


films are composed of wurtzite structure crystalline ZnO, with the exception of the line-patterned film before annealing. The degree of crystallinity was higher for the NB and NR films, which can be attributed to the fact that the structural voids were filled with nanocrystalline ZnO. The intensity of the (002) direction for all detected peaks was 0.48 for the NB film, lower than that of the NR film at 0.65. This means that crystal growth in the (002) direction was suppressed at 75°C but dominant at 90°C, which agrees with the morphologies of the fabricated ZnO nanostructure shown in Figure [2](#F2){ref-type="fig"}c,d.

![**Structural and elemental analysis of ZnO film at each fabrication step. (a)** XRD patterns, **(b)** XPS analysis of O1s region, and **(c)** Zn2p3 region.](1556-276X-9-428-4){#F4}

The chemical binding states measured usingmigrate to the surface and are trapped, leaving behind unpaired electrons to contribute to the photocurrent. When UV light is not present, oxygen molecules are re-adsorbed on the surface, retrapping free electrons, and the resistance is recovered.

Responsivity, defined as the ratio of the change of electrical current to the illuminated UV power, was calculated to be 1.66 × 10^4^, 4.67 × 10^5^, and 4.41 × 10^4^(A/W) for the single TA nanoline, NB nanoline, and NR nanoline, respectively. The responsivity of the NB nanoline was superior to the TA and NR nanolines. This result is noteworthy because both the electrical conductivity and responsivity of the ZnO nanoline were enhanced in the NB nanoline by the interior-architecturing, without the use of a high-temperature process of over 500°C \[[@B27]\]. We believe that fewer voids and interfacical trap


scroll as a way to _manually_
play them.

------
rauchp
To be fair, it is a nice site.

Those numbers definitely make it sound like it's not the ideal solution for
the client. But from Apple's perspective, does anyone know how much more their
servers are being taxed per-view? (Not sure if they have caching solutions to
alleviate the load. That is a lot of packets to send, though.)

------
droithomme
On my system it made 54 requests totaling 4.13MB of data. Artwork looks pretty
good, like it's more than 4MB.

This machine doesn't have retina. Maybe for retina machines it loads larger
artwork. Also there's a bunch of errors in the console including:

Error: WebGL: Disallowing antialiased backbuffers due to
blacklisting.main.built.js:10:16167

Error: Cannot find module '@marcom/ac-polyfills/Array/prototype.forEach' ac-
analytics.js:1:166

Strict-Transport-Security: The site specified a header that could not be
parsed successfully

The errors don't seem to have affected anything,18*c = 1215. Which is smaller: 242 or c?
242
Let l be (684/42 - -3) + 4/(-14). Which is smaller: l or -2?
-2
Let l = 9507/16 + -594. Suppose -3*v + 2*v = -4*a + 16, 2*a - 8 = -4*v. Is l at most v?
False
Let c be ((-1463)/(-660))/(1/(-9)). Let q = c - -81/4. Let h be 3/15 + (-12)/(-15). Which is smaller: h or q?
q
Suppose -3*h + 4*f - 350 = -102, -3*h - 276 = 3*f. Which is greater: h or -89?
h
Suppose 147 = 4*z + 11. Let t(y) = -y + 52. Let i be t(19). Is i < z?
True
Let j = -38 - -22. Let q = j - -4. Let o be 456/1197 + (-4)/(-14). Is o != q?
True
Suppose -4*j = 21*j -


the toilet; greywater can be collected in a household-scale reuse system and treated to a standard that is suitable for toilet usage. Untreated greywater can be used for garden watering if used immediately after it is produced – soil is effective at filtering out many contaminants in grey water. However, wastewater from kitchen sinks and dishwashers should not usually be collected as it is too heavily contaminated.

In our cities, we can treat and reuse wastewater for green spaces and in our industries and agriculture, we can treat and recycle discharge for things like cooling systems and irrigation. By using this valuable resource, we will make the water cycle work better for every living thing. It is thought that by 2050 nearly 70% of the world's population will livelong layers are here to five extra movements and fullness to fine hair for girls. Super short layers or too many layers don’t look good for fine hairs because it will give your hair a thinning look. It is one of the most trending short haircuts for fine hair which you can adapt by yourself if you know how to cut layers.

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Blunt Lob-Length Haircut:

You will look gorgeous in a Blunt lob length haircut as it presents your


the dangers of Carlos’ West Havana neighborhood, La Timba. What follows is a heartwarming journey of friendship and inspirational discovery as the selfish Mayito learns there are other joys than having the latest PlayStation. Featuring members of the internationally renowned children’s theater company La Colmenita, Padrón’s stylish film offers a telling portrait of...

Cuban director Ian Padrón presents his first feature-length film as “a fictional story about reality.” Tracing the lives of two Cuban classmates with contrasting lives, Padrón follows Mayito, a young boy whose wealthy jazz pianist father showers him with privilege, who gets lost and wanders blindly into the dangers of Carlos’ West Havana neighborhood, La Timba. What follows is a heartwarming journey of friendship and inspirational discovery as the selfish Mayito learns there are other joystacos first! We ate at these other places and they were delicious, too, but the first were the best. It was sort of a melancholy decline after that. But, hey, at least I got to eat them at all.

Our last stop was at Tacos El Poblano, a smaller restaurant with far fewer people, for tacos de asada. People love these. I didn’t get it. It wasn’t a bad taco; it was clearly good, but I don’t like extremely strong meaty flavors unless I’m straight-up eating a steak. The meaty flavor overpowered the others; there wasn’t that delicate balance.

More tacos for dinner. We went to Puesto in La Jolla, a louder, more festive place, where everybody was drinking varieties of margaritas. I had Baja-style fish tacos, beer-battered cod with


least, and I’d order it again.

Tuesday, August 7Had lunch with my agent. We went to Park Avenue Summer. They were doing a restaurant-week prix fixe. I got the summer gazpacho with peekytoe crab, strawberries, and avocado; New Zealand king salmon with cucumber, avocado, and crispy taro; and four cups of coffee. The gazpacho was tasty, but afterward I didn’t have all that much of an appetite for more.

Snacked on a handful of walnuts and leftover miso soup, cold!

I was in New York for another book event, and got there 25 minutes early, so I had an early dinner. I wandered a block until I found a restaurant where I’m sure I won’t recognize anyone: El Nuevo Portal, which had a lot of delivery and takeout bags and onlythe Institute Ethics Committee, Advanced Center for Ayurvedic Research in Mental health and Neurosciences, NIMHANS. Patients and/or relatives were explained about the nature and design of the study and informed consent was obtained.

2.1. Inclusion and Exclusion Criteria {#sec2.1}
-------------------------------------

Patients diagnosed with ischemic stroke by a neurologist and as*pakshaghata* (hemiplegia) by an Ayurveda physician by thorough clinical examination and imaging were screened from casualty section, stroke unit, and neurorehabilitation section, NIMHANS. Patients were included if aged between 20 and 60 years, of either gender; with first time ischemic stroke in middle cerebral artery (MCA) territory diagnosed by history, clinical examination and CT scan/MRI of brain, between 10 and 30 days of stroke, with stable neurological status following the necessary acute phase treatment after stroke, motor weakness of at least one


obtain the time domain and frequency domain parameters of blood pressure variability. Baroreflex sensitivity (BRS) values were derived by sequence and spectral methods using the same software as per guidelines \[[@B17], [@B18]\].

2.4. Control Data {#sec2.4}
-----------------

To assess the presence and extent of cardiac autonomic dysfunction in the ischemic stroke patients, similar ECG data was obtained from 30 clinically healthy subjects.

2.5. Description of Ayurveda Therapies {#sec2.5}
--------------------------------------

### 2.5.1. *Abhyanga* (Therapeutic Massage) {#sec2.5.1}

*Abhyanga* was performed during morning hours (8 am--12 noon). Patient was advised to empty bowel and bladder before starting the therapy. Patient was made to lie in supine posture over the*Droni* (*Abhyanga* table). Requisite quantity of*Niramisha Mahamasha taila* (medicated oil) was warmed on a water bath and applied on the patient\'s body. The entire body was then massaged by 2masseurs with uniform pressure using long strokes and in circular motion, as required \[[@B19]\].

### 2.5.2. *Svedana* (Sudation) {#sec2.5.2}

*Bhashpa sveda* variety of*Svedana* was done. The patient was made to sit in a*Bhashpa svedana yantra* (customized wooden box) into which warm vapors were passed. This induced perspiration in the patient. This was continued for 10--15 min depending on the patients\' tolerance level \[[@B19]\].

### 2.5.3. *Basti* (Therapeutic Enema) {#sec2.5.3}

*Matra basti* (therapeutic oil enema) variety of*basti* was used. The procedure was performed after noon (between 12 noon and 3 pm). Patients were advised to take light food and empty bowel and bladder before starting the therapy. Local*Abhyanga* and*svedana* was performed around the gluteal region. Following this, the patient was advised to lie down in the left lateral position on*Abhyanga* table with left led


Statistical Methods {#sec2.6}
------------------------

Statistical analysis was performed using SPSS. Chi-square and Fisher Exact test was used to find the significance of categorical data comparison between two groups of patients. Independent sample "*t*" test was carried out to compare (a) the HRV variables between pakshaghata patients and healthy subjects and (b) the baseline characteristics of the two groups of patients. 2 × 2 repeated measures analysis of variance (RMANOVA) was used to find the significance of study parameters within and between the two groups of patients. The two independent factors included in the analysis were (1) treatment (between-subjects factor) with two levels: conventional treatment with physiotherapy and conventional treatment with Ayurveda and (2) time (within-subjects factor) with two levels: baseline and after 2 weeks. The main effects when found toit was observed that the patients receiving adjuvant Ayurveda therapies demonstrated significant enhancement of time domain (SDNN) and frequency domain parameters (TP, LF power) of HRV. There was also a significant group effect for mean NN and RMSSD and adjusted pairwise comparison for group was significant in the group treated with adjuvant Ayurveda therapies. This combined with a trend for increase of the HF power and a marginally lesser LF/HF in this group. Though there was increase in LF power, no significant change was observed in LFnu or LF/HF ratio. Among the BPV measures, the SBP, DBP, and MBP showed a trend for decrease in both the groups but it was not statistically significant. We also did not find any significant changes in the other BPV parameters following


and private residences. We all liked to spend it in different ways: Hendrix gambled, Bowed whored, Chapman smoked, and I drank. There were others, though, like Corporal Adam Valenzuela who had met the stunning Aurelia Lopez and her two children. Her husband (their father) had been killed in combat on Pearl. None of us had thought Valenzuela would make anything of it, perhaps just a one-night stand.

But we were surprised. Rumor had it that the morning afterwards the two little ones had stormed the bedroom and Valenzuela, who had a soft spot for kids, couldn't bear to separate himself from their lives -- or their mother.

For me, though, I preferred the decor of the local bar to that of a widow's house. My favorite watering hole, though thereas well as I could without turning gruesome. There were some stock complaints I could throw out there: the food, the weather, the CO. All the time, she listened patiently, looking interested. I tried to shift the conversation to her, find out what she was like, but she always expertly brought the track back to me without revealing much about her. I never even found out her last name.

Finally we excused ourselves back to my room. Hendrix punched me lightly in the leg as we passed on our way out, though if this was encouragement or a warning, I didn't know. What I remember is that the next few hours are a pleasant, warm blur; the kind of memory I wish I could wrap myself in, especially with


winter looming in the next month. Her hair was very soft, and so was her skin, and her hands. Her lips and breasts were beyond soft, so soft that it made me feel soft just having touched them. It was a wonderful, blissful universe where I forgot entirely about the war, the Covenant, and the cold.

In the morning, she was gone, except for her panties.

Later that day, we had to return to the Boss, where I had to deal with a new problem: Thomas Pope. He was ripshit about how I had "stolen his girl," and went around the whole base telling everyone what a terrible jackass I was. The torrent of slander and curses that tumbled from his mouth may have swayed strangers by sheer volume, butwas subtracted from samples without α-amyloglucosidase. Glycogen content was determined using a standard curve submitted to the same conditions [@pone.0065125-Vital1].

Hexokinase Enzymatic Activity {#s2f}
-----------------------------

*Cytoplasm isolation:* The cell fractionation procedure used required large amounts of fresh eggs (at least 0,056 g respective to 250 eggs) to obtain the cytoplasm fraction. Eggs were homogenized in 1 mL of a buffer containing 0.5 M sucrose, 50 mM Tris-HCl pH 7.4, 100 µM leupeptin, 100 nM pepstatin and 20 mM MgCl~2~. The homogenate was centrifuged at 200 g for 2 min. The supernatant was carefully removed and centrifuged at 100.000 *g* for 1 hour for obtain the cytoplasmic fraction in the supernatant. *Hexokinase (Hex) cytoplasmic activity assay*: The samples were assayed in 20 mM Tris-HCl pH 7.4 containing 6 mM MgCl~2~, 1 mM


These ovaries either had their morphology analyzed by nuclear DAPI stainings or were submitted to glucose measurement as described above. Three independent biological replicates were performed. Glucose values were normalized in relation to the protein amount (Bradford method).

Comparison of Glycogen Content in Control (*LacZ* RNAi) and *Tc-GSK-3* Embryos {#s2h}
------------------------------------------------------------------------------

Fifty females were injected either with *Tc-GSK-3* or LacZ dsRNA at 50 ng/µl. Two days after female injection, males were added and eggs collected after 48 hours (0--48 hours) for both control and *Tc-GSK-3* RNAi eggs. Both groups of eggs were let for an additional 24 hour period (48--72 hours). Three independent biological replicates were performed. Glycogen content was measured as described in [@pone.0065125-Vital1] and the protein amount (Bradford method) was used to normalize each sample.

Results {#s3}
=======

The knowledge of glycogenlow between 12--16 hours in D,D'. (E,E') During germ band elongation (16--20 hours) *Tc-HexA1* expression is upregulated and occurs only in the embryonic region (emb in D), being absent in the serosa (ser). (F) Specific Hexokinase activity (U/mg protein). High activity is detected in egg extracts from 0--4 hours and after 16 hours, which correlates to *Tc-HexA1* mRNA expression pattern. pp - posterior pit, emb - embryonic tissue, ser - serosa.](pone.0065125.g004){#pone-0065125-g004}

These results stimulated the investigation of Hexokinase (Hex) activity during similar stages of embryogenesis. Thus, we isolated the cytoplasmic fraction of eggs in intervals of four hours of embryonic development in order to measure specific Hex activity. High levels of Hex activity are observed in the first four hours of development (0--4 hours - [Figure 4F](#pone-0065125-g004){ref-type="fig"}). A decrease


embryogenesis.

*Hexokinase* Duplication and Evolution {#s4c}
--------------------------------------

Our results also highlight an important feature of the *Hex* locus in *T. castaneum. Hexokinase* locus displays two paralogs (*Tc-HexA1* and *Tc-HexA2*) located in tandem in the beetle genome ([Figure 3A](#pone-0065125-g003){ref-type="fig"}). Interestingly, both genes appear to be expressed during embryogenesis ([Figure 3A](#pone-0065125-g003){ref-type="fig"}), although *Tc-HexA1*seems to be the only one activated during early stages of development. *Hex* duplication has also been reported in *Drosophila melanogaster*, where four *Hex* genes are present in the genome. Interestingly, flight muscle Hexokinase-A (Hex-A) is the most conserved and essential hexokinase isozyme among *Drosophila* species [@pone.0065125-Jayakumar1], [@pone.0065125-Duvernell1]. The other three hexokinases in *D. melanogaster* are expressed in the fat body (HexC) and in the testis (Hex-t1 and Hex-t2) suggesting that *Hex* duplication and putative metabolic changes might be more frequentManifesting success as an actor, singer, public speaker, performer.

The world is massive, the competition is vast and brilliant and your ‘realistic’ or ‘pessimistic’ brain constantly gets in the way of your advancement. Relationships are getting in the way of your career, or you are questioning whether you want the time commitment and risk of a career over a family. You always hit walls and you don’t know how to escape your cycle.

This is the reality of the modern world of the performer. Go back 50 years and the world seemed a lot smaller. Our greatest known artists remained in a particular location and their voices were heard through records which were limited. There was no internet, so not everyone was privy to the world of performing. Some countries


will get the role, or you won’t get the role, but you will have gained experience (which is a HUGE deal for auditions), potential contacts and you have more time to audition for other roles or other conservatories. Imagine going into an audition where both outcomes are the best possible outcome. Think about the stress that this would take off your shoulders! Think about how significantly this would improve your audition.

If you do get given the role, be grateful for the opportunity. Do not over-do the gratitude to the casting director. I often find that “Thank you very much. This is a wonderful opportunity and I look forward to working with you” works really well. Be sincere, but don’t break out into tears unless you are on livebody language in training or games, whether it be the disappointment of a misplaced pass or the agony of a spurned chance. The Dutch coach doesn't want to give opponents a sniff of against a disciplined and rugged Australian side whose tactics hinge on heaping frustration upon sides ranked significantly higher.


Shared musings by Wayne Abernathy on how the eternal things make all things new. A brief consideration. . .

Menu

Of Christmas and Faith in Miracles

The events associated with the birth of the Savior occurred in a miraculous time during an age of miracles. It was also an era of grinding poverty, breathtaking opulence, and many gradations of wealth in between. People were ignorant, well educated, parochial in vision, and metropolitan in view. Religious beliefs involved spurious superstitions, animistic traditions, polytheistic practices, monotheistic faith, and sophisticated atheism.

That is to say that those times and ours have more in common than we might have supposed, which is the point of my writing this evening. Perhaps we create too much distance between us and the birth of the Savior. Measured in humanPeugeot 5008

The force of Storm Doris may have caught many off guard; but while she was tearing up trees at home, I was in Lisbon getting a preview of something which is sure to have a huge impact of its own when it finally makes land fall in Ireland this July. The all-new Peugeot 5008 makes its departure from its former traditional MPV body shape in favour of a new 7-seater SUV form. This new look 5008 is well poised to piggy back on the fantastic response which its 5 seat sibling the 3008 has received. Since the 3008 was launched in October, over 80,000 orders have been placed in Europe alone. Now the 5008 will go head to head with the new Skoda Kodiaq for the 7


a segment that is showing real demand and a lot of potential. Together with the arrival of the critically acclaimed new 3008, the 5008 SUV is sure to bring new customers to the Peugeot brand in Ireland. ”

Prices and specifications for the new 5008 SUV for the Irish market will be announced closer to launch but we should see the 5008 coming in at around the €29,000 mark. If that is the case, then it’ll undoubtedly prove to be a another hugely successful SUV venture for the French manufacturer.builder.

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However, the operational failures have direct impact to patient safety and patient care. Therefore, no matter the level of risk involved in improvement science studies, there is a direct impact to patient safety and any delay in approving improvement science studies because of variance in IRB review directly impacts patient care.

In summary, steps and strategies implemented by the ISRN are believed to have helped each of the 14 study sites in successfully achieving timely IRB approvals. Using template IRB documents provided by the Network, each site was given responses to each question on the IRB application reducing the turnaround time for submission. Furthermore, each PIK sent to the site PI included a sample consent form and HIPAA document which eliminated the need for the site PI to developthrough which the liquid silicone composition is forced into the mold cavity, the dripping of liquid silicone composition is prevented out of the nozzle opening of the injection molding apparatus, and accordingly, there is no waste of silicone composition. Further, there are not any runners or cured parts of silicone composition hanging on to the molded part which have to be cut off or removed from the molded part so as to result in the final molded part. Other molding machines or molding apparatuses had drippings or threads hanging on to them which had to be removed before the molded part was ready to be sold and put to its final end use. The drop parts or drip formed portions of the part or threads were unsightly and/or


The castle and grounds from the air. Completed in 1806 by London-based architect Joseph Bonomi, this neo-classical mansion replaced a castle burnt down in 1802. It was used as a military hospital during the First World War and was home to Queen Victoria's daughter Princess Louise, the Dowager Duchess of Argyll, until her death in 1939. It was an HQ for the Rosneath Naval Base in World War Two, then abandoned, then damaged by fire in 1947, and demolished in 1961. Image date unknown.does not amount to a violation of Plaintiff's constitutional rights.

3. Physical injury requirement

Defendants also argue that Plaintiff's Eighth Amendment claim cannot go forward because his allegations do not meet the physical injury requirement. "No Federal civil action may be brought by a prisoner confined in a jail, prison or other correctional facility for mental or emotional injury suffered while in custody without a prior showing of physical injury." 42 U.S.C. § 1997e(e). Failure to allege *905 and establish an appropriate physical injury is ground for dismissal, see Zehner v. Trigg, 952 F.Supp. 1318, 1321-35 (S.D.Ind.) (dismissing action for damages because no plaintiff developed physical injury by exposure to asbestos while in prison), aff'd, 133 F.3d 459 (7th Cir.1997). The qualifying physical injury need not be significant, but it


including a strong economy and an end to corruption – have not been laid.

“Once we are economically, financially and politically independent, only then will we be truly independent,” Kara Alsarraj said between sips of tea at a popular shop in the shadow of Erbil’s world-famous citadel.

One Western official, speaking on background because of the need to work with both sides, said the future of Iraq rests with whether the Kurds press for independence or not.

“Question No. 1 is: Does everyone agree that Iraq should hold together?” the official said. “Because if you don’t agree that it should hold together, you’re not going to reconcile. And that’s all about the Kurds. Are the Kurds in or are the Kurds out?”

Mustafa insists any push for independence will be peacefully negotiatedQ:

how to add a menu into the Safari MenuBar or add a button into it's MainWindow?

I want to develop a plugin with Safari. Now I wan to make a demo for add a button into it's MainWindow or menu into it's MenuBar. I have seen to Document WebKitPluginProgTopic and the sample:/Developer/Examples/Webkit/WebKitMoviePlugIn . But they didn't tell the full process of make a plugin with safari and how to add some menu or button in the safari window . Someone can give me some advice or simple code to resolve this problem, Thank you very much!

A:

The plug-in architecture isn't thought for enhancing the browser but to support special media formats like flash or quicktime. The problem is that the plugin is only loaded when the corresponding media type is


law of Maryland.
The following terms will be used in this opinion:
"Bowl America" to mean Bowl America, Inc., together with its wholly-owned subsidiaries, including all plaintiffs in this case;
"Fair Lanes" to mean Fair Lanes, Inc., together with its wholly-owned subsidiaries, including the corporate defendants;
"Defendants" to mean all defendants, individual as well as corporate;
"Bowling establishments" to mean any facility for tenpin or duckpin bowling open to the public, together with related facilities for serving food, selling bowling supplies, etc.;
The "bowling business" to mean the operation of one or more bowling establishments;
"Metropolitan Baltimore" to mean the area from the center of the City of Baltimore to eight miles beyond the Baltimore Beltway;
The "five Bowl America establishments" to mean the houses at Cedonia, Dundalk, Glen Burnie, Odenton and Reisterstown, which were operatednext election.

No true friend would have the expectation you compromise your principles just so they can get elected. If they do, take good measure of it, they are not your friend. They will compromise what little principle they have at your expense, when it is to their benefit.

In this you have no real friendship. There is not even a meaningful relationship. It is an association best ended.

The time for sitting on fences is over.

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sites around the globe carry a special distinction as sacred sites. These destinations inspire travelers, by their history or mystery, to step beyond the familiar confines of daily patterns to enter a world of expectation, eyes open to new information, new interpretations, and new horizons.

But the attitude of pilgrimage can be carried on every trip, even an afternoon hike in a nearby woods. One need only set forth with awareness that the sacred emerges where we seek it. "Teachings are everywhere--all around us, if only we open the mind's eye to see. Awareness of life is what makes life special," writes Gyomay Kubose, author of "The Center Within." "Unless we are aware, we do not learn anything. We have no inspiration and no teachings."weekends or after school, like, at night, and I would just sit, and drink and eat.”

After deciding she might as well get paid for her time at SUR Lounge, because she was there so frequently, Schroeder’s longtime friend, Kelly, spoke with Guillermo Zapata (one of the four owners of the restaurant, along with his wife, Lisa Vanderpump and Ken Todd) and got her an interview. Although Schroeder lied during the interview, about her past experience in restaurants, which she didn’t have, Schroeder was ultimately brought on board, and years later, began starring on Vanderpump Rules.

Towards the end of Bravo’s Stassi Schroeder’s Podcast, she confirmed that she “loves SUR,” and had a great time working at the restaurant years ago, before Vanderpump Rules began.

“It’s a great vibe and, of