GENIE DAQ is separated into individual runs of roughly for each of the two detectors Ge6 and Ge7. This enables the stability check of the DAQ system over the extended period of measurement and the removal of individual runs.\
The stability was checked by plotting the count rate and peak centroid of the background peaks at and as a function of time (spectrum number). Although counting statistics prevented detailed analysis of the short term stability, it was clear that there was no measurable energy drift during the measurement period. In addition, quality controls with a point source containing , and were carried out before, after and once in-between the measurement. The average activity concentration in the laboratory during the data taking was measured to and at no point higherthan . No correlation to the background count rate was observed mainly due to effective Rn-removal by minimizing empty space inside the shield and flushing with N$_{2}$. The count rate remained stable over the 32 runs with one exception; in the first two runs an increase in total counts and counts from was observed, however not from . This behavior was cross checked with additional visible  from and , and representing the and decay chains respectively. The increased count rate of the chain in the first days is only seen in the lower Ge6 with a Cu endcap and not in the upper Ge7 with an Al endcap. One possible explanation is that the short half-life of () implies that it is not flushed out by boil-off nitrogen


and that its daughters preferentially stick to the copper surface of the lower detector (Ge6) than to the aluminum surface of the upper detector (Ge7). with longer half-life () will be flushed out of the shield before a significant amount of daughters are produced.

Consequently, the first two runs are removed from the analysis resulting in a total of 30 runs with of good data out of 32 runs with total data which translates into a total exposure of .

Data Processing
---------------

For the final analysis a single energy spectrum is used for which all individual runs are summed: In a first step, all selected runs of one detector are combined with the same energy calibration. In a second step, the single detector spectra are rebinned into a common binning ofor downwards. The sensitivity of an experiment is then defined as a resulting signal which originates from a upward fluctuation of the background. This can be calculated before performing the experiment if the background is known. In case of the observation of a downward fluctuation, which formally results in negative signal counts, the signal is usually set to zero and the sensitivity is quoted as an upper limit of the counts. On the other hand, when using classical uncertainties on the observed downward fluctuated counts, it is possible that in some cases even the upper limit its negative. In these cases it results in a poor coverage of the quoted confidence level at best and in an unphysical negative result at worst. Additionally there is a discontinuity in


the system, the flat background function was defined closer than into the signal region to improve the background estimation.\
The observed counts in the analysis bin are compared to the expected background with the ROOT class TFeldmanCousins, which returns the lower and upper bound of the signal confidence interval according to a specified confidence level that is set to in this work. All investigated peaks show a lower count limit of zero; this is in agreement with a non-observation of the peak. To account for the incomplete coverage of the peak area by the analysis bin, the upper count limit is divided by the fraction of coverage and thus adjusts the upper count limit in a conservative way.\
An illustration of the technique is shown in \[fig:657keV\] to \[fig:468keV\] withOxidative enantioselective α-fluorination of aliphatic aldehydes enabled by N-heterocyclic carbene catalysis.
Described is the first study on oxidative enantioselective α-fluorination of simple aliphatic aldehydes enabled by N-heterocyclic carbene catalysis. N-fluorobis(phenyl)sulfonimide serves as a an oxidant and as an "F" source. The C-F bond formation occurs directly at the α position of simple aliphatic aldehydes, thus overcoming nontrivial challenges, such as competitive difluorination and nonfluorination, and proceeds with high to excellent enantioselectivities.


our optimized ZrB$_2$ force field. $\lambda$ is the regularization parameter; $K$ the number of bispectrum components; $R_\mathrm{cut}$ the cutoff radius of the neighbor density function; $R_{zbl, i}$ and $R_{zbl, o}$ the inner and outer cutoff of the switching function for ramping the energies, forces and curvatures smoothly to zero; $Z_\mathrm{Zr}$ and $Z_\mathrm{B}$ the atomic number of the Zr and B atoms.

\[table1\]

DFT datasets
------------

A pool of diverse atomic configurations needs to be included in the DFT reference dataset in order to represent the widest variety of local atomic environments. Such diversity is critical for the construction of a robust force field able to fully capture the features of the potential energy surface. Our training dataset comprises a total of approximately 150,000 local atomic environments extracted from 1850 configurations, while thewere not explicitly included in the training.[]{data-label="fig.1"}](Fig1.jpg){width="2.8in"}

Furthermore, the SNAP force field demonstrates an excellent performance on describing the energy landscape against the variation of structural parameters as shown in Fig. \[fig.2\]. In this case the target property is the dependence of the total energy over the lattice parameters, $a$ and $c$, which are changed with respect to their equilibrium values. The DFT references for this test are contained in [*EOS II*]{} dataset, which is not used for the training. Note, in fact, that the largest lattice strain included in the training set is of only 1.3% ([*EOS I*]{} dataset, see the corresponding region marked using the grey box in Fig. \[fig.2\]). In Fig. \[fig.2\] it is easy to observe that the SNAP predictions are within a deviation of 20 meV/atom from their


temperature. The SNAP results (in red) obtained from $NPT$ molecular dynamics (averaged over 100 ps) are compared with the those from DFT PBE+D2 (in blue) and experiments [@Okamoto2010] (in black). []{data-label="fig.4"}](Fig4.jpg){width="2.8in"}

We then move to determine the temperature dependence of the elastic tensor, $c_{ij}$, as computed from SNAP. This quantity is determined from the trajectories of $NVE$ molecular dynamics simulations by using the explicit deformation method [@Clavier2017] (see computational details in the SI). During the simulations the lattice parameters as a function of temperature, $a(T)$ and $c(T)$, are fixed to those previously derived by SNAP and reported in Fig. \[fig.5\].

![(color online) Variation of the elastic constants, $c_{ij}$ (GPa), with temperature. The SNAP results (in red) are extracted from the $NVE$ trajectories over a 250 ps interval after an initial equilibration of 150 ps. Results are$c_{44}$ can then be obtained by increasing the training set to add sheared configurations. This, however, should be done without unbalancing the training set, that otherwise will be unsuitable to capture the behaviour of the remaining $c_{ij}$ constants. Considering the general good agreement of the overall elastic tensor this further refinement has not been performed.

Finally we turn our attention to the variation of the thermal conductivity with a wide range of temperatures, which is satisfactorily derived using our SNAP force field. In this case the lattice thermal conductivity tensor, $\kappa_{ij}$, is calculated by using the equilibrium Green-Kubo formalism [@Zwanzig1965]. In particular, $\kappa_{ij}$ is evaluated from $NVE$ molecular dynamics simulations of heat flux up to 40 ns, a time needed to achieve convergence at temperatures comprised between 300 K and 2500 K (see


the Debye-Slack model. At lower temperatures the agreement is less good with the SNAP predictions being constantly above the Debye-Slack curve. This is expected, since the Debye-Slack model is designed to estimate the thermal resistivity at temperatures above the Debye temperature, $\theta_\mathrm{D}$. In fact, it assumes Umklapp scattering to be the dominant process limiting the thermal conductivity and completely ignores contributions from scattering to the optical phonon branches. This kind of approximation works in the high temperature limit, but underestimates $\kappa_\mathrm{ph}$ for $T<\theta_\mathrm{D}$. In contrast, our SNAP force field provides a robust tool to perform molecular dynamic simulations of heat transfer over the full temperature spectrum. At the same time it bears a much higher accuracy and efficiency.

Finally in Fig. \[fig.6\](c) we compare the total thermal conductivity, $\kappa_\mathrm{tot}=\kappa_\mathrm{ph}+\kappa_\mathrm{el}$, withwas 9, 13-di-cis-RA, but its embryonic concentrations were only about 6% of those in plasma. In the embryo, retinol and its esters were found at high concentrations; lower amounts of all-trans-4-oxo-RA and the newly identified 14-hydroxy-4, 14-retro-retinol could also be measured. Embryonic concentrations of all-trans-RA were about 100% higher than endogenous levels. The overall exposure of the embryo to this retinoid was, however, substantial. Embryonic area under the concentration time curve values strongly suggest that the embryotoxicity of the applied dosing regimen is mainly due to the action of all-trans-RA. A very remarkable finding of this study is the marginal increase of plasma concentrations of all-trans-RA over their endogenous levels, which is comparable to the human situation after vitamin A intake. This analogy indicates that high vitamin A


1-0 Atletico Madrid

...it is not great from Lionel Messi, though, as he curls the ball over the bar.

90 mins

Post update

Barcelona 1-0 Atletico Madrid

Three minutes of stoppage time and Barcelona win another free-kick, Lionel Messi drawing the foul out of Diego Godin right on the edge of the area, central. Messi territory...

88 mins

SUBSTITUTION

Barcelona 1-0 Atletico Madrid

Luis Enrique wants to protect this advantage and on comes defender Marc Barta for Andres Iniesta, while Atletico throw on forward Raul Jimenez for Gabi.

86 mins

Post update

Barcelona 1-0 Atletico Madrid

How will Atletico react now? For so long they had seemed content to play for the draw, but will they go for it now? Four minutes remaining.

85 mins

goal

GOAL

Barcelona 1-0 Atletico Madrid - Lionel Messi

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Lionel Messi takes the penalty, it is straight atwere good and caused them problems. It is difficult to have the belief you can get a goal when you come here but I can't fault their work ethic or spirit.

"We are in it, you heard the noise 4,000 fans were making and when 25,000 are in our place next week, it is going to be special. We are going to give it everything we can."

46 mins

KICK-OFF

Barcelona 0-0 Atletico Madrid

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Fancy Fernando Torres to add to his two goals against Real Madrid? Well it isn't going to happen. He is replaced at half-time by Mario Mandzukic and we are under way in the second half.

Posted at 22:05 21 Jan 201522:05 21 Jan 2015

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Join the debate at #bbcfootball

Barcelona 0-0 Atletico Madrid

Still with us? Good, then let's have


mins

goal

GOAL

Tottenham 1-0 Sheff Utd - Andros Townsend

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Blades keeper Mark Howard dives the right way but Andros Townsend's penalty is well hit and bulges the back of the net. Advantage Spurs.

ReutersCopyright: Reuters

72 mins

PENALTY TO TOTTENHAM

Tottenham 0-0 Sheff Utd

Jay McEveley handles a ball into the box and it is a chance here for Tottenham, penalty...

21:29

Championship update

There could be a comeback on the cards at Brighton too, where Ipswich have got one back through Freddie Sears to make it 3-2. That's the former West Ham striker's first goal for the club.

At Craven Cottage, Nottingham Forest still trail Fulham 3-2. About 10 minutes remaining in those games.

Posted at 21:34 21 Jan 201521:34 21 Jan 2015

Post update

Tottenham 0-0 Sheff Utd

Former Spurs and England midfielder Jermaine Jenas

BBC Radio 5 live atSheff Utd

Tottenham appear to have identified the threat of Jamal Campbell-Ryce on the right and have nullified it in this half, meaning Sheffield United are having to switch their attacks to the other flank, where they are not having much joy. There looks to be movement on the Tottenham bench, Roberto Soldado preparing to come on.

Posted at 21:19 21 Jan 201521:19 21 Jan 2015

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Tottenham 0-0 Sheff Utd

Craig Scott, London: Alright Poch, Emmanuel Adebayor has had a go, it's not working. Harry Kane back to a central role with Roberto Soldado feeding. No time left to experiment in this match.

Get in touch via text on 81111 (UK only) or on Twitter via #bbcfootball.

21:18

Post update

Barcelona 0-0 Atletico Madrid (21:00 GMT)

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Not much to report from the Nou


it 1-1. About 25 minutes played there.

9 mins

Post update

Tottenham 0-0 Sheff Utd

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Tottenham win the first corner of the game which Andros Townsend takes, no Sheffield United player can clear and the ball runs through to Harry Kane. You'd fancy the big man to get a decent shot off but no, the ball squirms away from him as a result of a poor first touch and the chance is gone.

20:08

Championship update

There's been another goal at Craven Cottage and it's another one for Ross McCormack. Fulham now lead 2-0 over Nottingham Forest.

There's been a goal at the Amex Stadium too and it's good news for Bournemouth fans - Brighton have taken the lead against Ipswich, Sam Baldock with a screaming drive to open the scoring.

7 mins

Post update

Tottenhamimportant thing. If we can go get a goal we will do but the main thing is to ensure we keep it close for the return leg."

Posted at 19:37 21 Jan 201519:37 21 Jan 2015

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Your team's greatest giant-killing

On the back of Sheffield United's impressive record against Premier League sides, what is the most memorable giant-killing your side has achieved?

Steve, Wakefield: How's about Scarborough beating Chelsea 3-2 in the League Cup in October 1989?

Chris, Bradford: Of course the biggest upset was Bradford going all the way to Wembley in 2013 beating Wigan, Arsenal and Aston Villa over two legs. Even 5-0 in the final couldn't diminish the memories of that run!

Nick, Yorkshire: It WILL be Cambridge United beating Manchester United reserves this Friday in the FA


Cup...

Get in touch via text on 81111 (UK only) or on Twitter via #bbcfootball.

19:37

Hard work to pay off?

Tottenham v Sheff Utd (19:45 GMT)

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A bit of adrenaline may have been wasted by the late kick-off drama so it might be worth the Sheffield United players having a bit of a breather before kick-off, as they may need to conserve energy given Tottenham's habit of scoring late goals this season.

Christian Eriksen's late winner against Sunderland on Saturday means Spurs have now earned 10 Premier League points thanks to goals in the 88th minute or later.

19:34

Post update

Tottenham v Sheff Utd (20:00 GMT)

It's all good for Sheffield United as the players are out on the pitch going through their warm-up routine. How late do you have to be beforethe 'matey-matey' football played in the top flight.

"Premier League teams aren't used to getting barged about, people in the faces, kicking them and not helping them up when they get kicked. It works for us," says Baxter. "There's a lot of matey matey stuff in the Premier League. I've got a couple of mates in football but I don't like it at all - hugging and kissing each other before games and all that."

19:25

Should have walked...

Tottenham v Sheff Utd (20:00 GMT)

Henry WinterCopyright: Henry Winter

Posted at 19:30 21 Jan 201519:30 21 Jan 2015

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Tottenham v Sheff Utd (20:00 GMT)

Matthew Parkin: How can Adebayor with zero leadership skills be appointed captain? It's an insult to the other 10 players!

Posted at 19:31 21 Jan 201519:31 21 Jan 2015

"Adebayor


earlier this month.

Post update

Tottenham v Sheff Utd (19:45 GMT)

Ian Dennis

BBC Radio 5 live senior football reporter

"We have a delay to kick-off and at the minute I am told the police are not giving Sheffield United an escort and therefore we cannot tell you exactly when the kick-off will be. The officials have to give the players 45 minutes to warm up before the game starts. It could be that we are looking at 20:00 GMT kick-off, and conceivably we could be looking at an 20:15 kick-off."

Posted at 19:06 21 Jan 201519:06 21 Jan 2015

BreakingKICK OFF DELAYED

Tottenham v Sheff Utd (19:45 GMT)

Tottenham have now confirmed that kick-off has been delayed and the game will get under way at 20:00 GMT.

19:04

Kick-off delayed?

Tottenham v Sheff Utd (19:45 GMT)

Rory SmithCopyright: Rory Smith

19:03

Teamwill always be some that hate you."

Posted at 18:54 21 Jan 201518:54 21 Jan 2015

BreakingBREAKING TEAM NEWS

Tottenham v Sheff Utd (19:45 GMT)

Emmanuel Adebayor starts his first game for Tottenham since 2 November and captains the side. Michel Vorm is in goal.

Coming up on BBC TV and radio

You can listen to full coverage of tonight's game on BBC Radio 5 live, where former Tottenham and England midfielder Jermaine Jenas joins Ian Dennis in the commentary box. There'll be build-up from White Hart Lane from 19:00 GMT.

And later you can watch highlights of both semi-finals, including yesterday's 1-1 draw between Liverpool and Chelsea, on The League Cup Show. That's on BBC One at 23:15 for viewers in England and Wales, 23:45 for viewers in Northern Ireland, and 00:15 for viewers


it is Sheffield United.

Already this season they have seen off West Ham, Southampton and QPR in cup competitions, while Aston Villa and Fulham fell victim to them in last season's FA Cup. In total they have only lost twice in 19 cup games under Nigel Clough.

Blades to cut down another giant?

For Tottenham fans of a certain age, thinking back to 2 March 1993 might make them wince...

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...it was on that day Spurs suffered one of their heaviest defeats - a 6-0 hammering by Sheffield United, Brian Deane among the scorers that day, Teddy Sheringham failing to impress for Spurs.

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Two divisions and 45 places separate the two sides today as they meet in the semi-finals of the Capital One Cup. It is arelevant articles published until 19th March 2013: 'valproate', 'valproic acid', and 'status epilepticus'.

The following search strategy was applied: (('valproic acid' \[MeSH\] OR valpro\* OR valproic acid OR valproate) AND ('status epilepticus' \[MeSH\] OR status epilepticus)).

All resulting titles and abstracts were evaluated, and any relevant article was considered. There were no language restrictions.

All identified studies were cross referenced to identify any reports that may have been missed. The manufacturer of valproate (Sanofi-Aventis) was asked for any reports of further unpublished studies. For the analysis of efficacy, case reports were excluded, since it is not possible to determine response rates from individual cases. For the same reason, studies in which multiple AEDs were evaluated without presentation of results for individual AEDs were also excluded. Studies using intravenous valproate as first-line


phenobarbital \[[@CR53]\]. These studies included 361 patients (183 were randomized to receive valproate; Table [1](#Tab1){ref-type="table"}; Fig. [1](#Fig1){ref-type="fig"}). The phenobarbital study \[[@CR53]\] and one diazepam study \[[@CR43]\] included only children; one phenytoin study \[[@CR46]\] included only adults, whereas the remaining studies \[[@CR41], [@CR42], [@CR52]\] included all age groups. The most frequent SE was generalized convulsive. Valproate was administered most often at an initial bolus dose of 20 or 30 mg/kg (Table [2](#Tab2){ref-type="table"}).Table 1Randomized comparative studies evaluating intravenous valproate monotherapy in the treatment of status epilepticus. Studies are listed in decreasing order of sample size. All studies were carried out as single-center open-label trials, except Malamiri et al., which was conducted in two centersReferences*N*PatientsType of SEDose regimenAgarwal et al. \[[@CR42]\]V: 50, P: 5062 adults/38 children (\<18 y), 67 male/33 femalePrimary generalized seizures: 14, JME: 2V: Initialperformed using Review Manager 5.2 (available at: <http://tech.cochrane.org/revman/download>). *CI* confidence interval, *DZP* diazepam, *IV* intravenous, *PHT* phenytoin, *VPA* valproic acidTable 2Non-randomized comparative studies evaluating intravenous valproate monotherapy in the treatment of SEReferences*N*PatientsType of SEDose regimenTripathi et al. \[[@CR49]\]V: 41, L: 41Adults (\>14 y), 42 male/40 femaleRefractory GTC SEV: Initial bolus 30 mg/kg at 5 mg/kg/min, L: initial bolus 30 mg/kg at 5 mg/kg/minTiamkao and Sawanyawisuth \[[@CR48]\]V: 32, P: 37^a^Adults (\>15 y), No information on genderGTC SEV: Initial bolus 15--25 mg/kg with max infusion rate of 50 mg/min, P: Initial bolus 15--20 mg/kg with max infusion rate of 50 mg/minKalita et al. \[[@CR50]\]V: 65, P: 5222 children (≤12 y), 95 adults, 73 male/44 femaleGTC SE: 108, NCSE: 9V: Initial bolus 30 mg/kg, P: Initial bolus 20 mg/kgAlvarez et al. \[[@CR51]\]V: 59, P: 70, L: 58Adults (\>16 y), No information on


of 19 non-responders to phenytoin (79 %) responded to valproate compared with 3 of 12 non-responders to valproate (12 %) who responded to phenytoin (*p* = 0.004). Seizure freedom at 24 h was obtained in 29 patients, irrespective of treatment group or sequence. However, the use of a maintenance AED regimen after the bolus infusion was not reported in this study.

In the second study \[[@CR46]\], treatment success was defined as clinical seizure cessation after infusion without need for rescue medication within 20 min of the infusion. No statistically significant difference in the rate of treatment success was found among patients treated with valproate (13 of 18; 72.2 %) and phenytoin (seven of nine patients; 77.8 %). Seizure freedom at 24 h was obtained in all patients (100 %) in both groups.

In the study comparing valproate with phenytoin12 (24 %) and 37 (76 %) patients were treated with intravenous valproate and phenytoin as first-line treatment, respectively. Treatment success was defined as the cessation of seizures by either clinical or EEG evidence. SE ceased in 9 of 12 patients (75 %) with intravenous valproate and 17 of 37 patients (46 %) with intravenous phenytoin as first-line treatment (difference not statistically significant), whereas it ceased in 7 of 20 (35 %) patients who received second-line valproate.

Kalita et al. \[[@CR50]\] conducted a prospective study in children and adults with convulsive and non-convulsive SE, comparing first-line intravenous valproate with first-line intravenous phenytoin. A total of 65 patients received valproate and 52 received phenytoin as a first-line AED, which resulted in control of SE in 56 % of patients with valproate and 44 % of patients with


cases. The local tolerability of intravenous valproate was also good, with only two subjects reporting injection-site pain. Mild hyperammonemia and mild thrombocytopenia were reported in four patients each.

### Case Reports {#Sec23}

A number of case reports have appeared in the literature describing idiosyncratic adverse reactions to intravenous valproate in patients with SE. Several of these have described cases of encephalopathy. For example, Rossetti and Bromfield \[[@CR76]\] have described two patients developing acute encephalopathy within 48 h of receiving intravenous valproate for the treatment of SE. Serum valproate concentrations were in the therapeutic range. In these cases, encephalopathy was associated with hyperammonemia twofold higher than normal. Symptoms resolved after reduction of the valproate dose. Embacher et al. \[[@CR77]\] described a woman who developed symptoms of encephalopathy within 24 h of receiving intravenousprimary tumour formation as well as metastases in nude mice \[[@B22-viruses-04-01537]\]. Similarly, EBNA1 expression in gastric carcinoma cells enhanced tumourigenicity in nude mice \[[@B23-viruses-04-01537]\]. In addition, EBNA1 expression in Hodgkin's lymphoma cells was found to enhance their ability to form tumours in nonobese diabetic-SCID mice, but not in regular SCID mice \[[@B24-viruses-04-01537]\]. Finally, Kaul *et al.* \[[@B25-viruses-04-01537]\] reported that expression of EBNA1 in a breast carcinoma cell line promoted the rate of tumour growth in nude mice and increased lung metastases. Together the results strongly support a role for EBNA1 in altering cell properties to promote tumour growth.

3. Molecular Mechanisms of EBNA1 Cellular Effects
=================================================

3.1. Destabilization of p53
---------------------------

Several aspects of viral infections can induce p53 leading to cell cycle arrest and induction of apoptosis. To avoid this antiviral response,


some viral proteins are known to sequester or destabilize p53. While EBNA1 does not bind p53 directly, a connection between EBNA1 and p53 was discovered using proteomics methods (affinity column profiling and tandem affinity purification (TAP) tagging), where EBNA1 was found to interact with the cellular ubiquitin-specific protease USP7 (also called HAUSP \[[@B26-viruses-04-01537]\]). USP7 can bind p53 and Mdm2 (an E3 ubiquitin ligase for p53) and stabilize these proteins by removing the polyubiquitin chains that normally signal degradation \[[@B27-viruses-04-01537],[@B28-viruses-04-01537],[@B29-viruses-04-01537]\]. A combination of biochemical experiments and structural determinations revealed that EBNA1, p53, and Mdm2 compete for the same binding pocket in the N-terminal TRAF domain of USP7, and that EBNA1 uses amino acids 442--448 to contact USP7 \[[@B30-viruses-04-01537],[@B31-viruses-04-01537],[@B32-viruses-04-01537],[@B33-viruses-04-01537]\]. However, EBNA1 binds this pocket with higher affinity than either p53== 'c' ) { loop_with_extra_call(); } return 0 ; }

Building the code with gcc version 4.8 (same output code is produced by 4.6, as well as when replacing -O2 by -O3 ):

$ gcc -O2 loop-call-weirdness.c -o build/loop-call-weirdness

Now I'll run it on my Intel i7-4771 (Haswell) CPU. First run the version with tightloop :

$ perf stat -r 10 -e cycles,instructions build/loop-call-weirdness t Performance counter stats for 'build/loop-call-weirdness t' (10 runs): 2,659,506,002 cycles # 0.000 GHz ( +- 0.19% ) 2,401,144,539 instructions # 0.90 insns per cycle ( +- 0.00% ) 0.685642994 seconds time elapsed ( +- 0.24% )

... and with the extra call:

$ perf stat -r 10 -e cycles,instructions build/loop-call-weirdness c Performance counter stats for 'build/loop-call-weirdness c' (10 runs): 2,336,765,798 cycles # 0.000 GHz ( +- 0.34% ) 3,201,055,823


cars, and street machines. At the end of the weekend, the best of the best were recognized with one of the Sacramento Autorama trophies.

The most coveted award of the Sacramento Autorama was the Custom d’Elegance which was given to the best chopped, channeled and sectioned vehicle from 1935-1948 that embodied the true spirit of a classic custom. This year, Troy Ladd of Hollywood Hotrods beat out the other five contenders earning his spot customizers like Gene Winfield, Joe Bailon, George Barris, and John D’Agostino on the perpetual plaque as well as $2,000 in prize money. Troy Ladd’s car, a 1936 Packard called the ‘Mulholland Speedster’ and owned by Bruce Wanta, is now also the only vehicle in history to win both the America’s Most Beautiful Roadster and Customd’Elegance titles.

‘Mulholland Speedster’ built by Hollywood Hot Rods

“The best thing about the Sacramento Autorama is that it gives custom builders a place to show off their vision of how they feel these classics should have looked originally,” said John Buck, owner of Rod Shows and producer of the Sacramento Autorama. “This year’s winners were shining examples of that. Troy Ladd’s history-making win as the first builder to ever win both the ‘Custom d’Elegance’ and ‘America’s Most Beautiful Roadster’ titles shows just how amazing his ‘Mullholland Speedster’ really is.”

The other top award at the show was the King of Kustoms, which recognized the best 1935-1964 custom build with particular focus on bodylines, design, flow, and quality of workmanship. Along with those features the judges also considered the use of


with the jxt domain (Fig. [3d](#Fig3){ref-type="fig"}), and the association of GGA2 VHS-GAT was not affected by the GAT mutations N211A, F280R, R281E, and L293A (Fig. [3d](#Fig3){ref-type="fig"}), which reportedly reduce binding of GGAs to ARF1, rabaptin5, phosphatidylinositol 4-phosphate (PI4P), and ubiquitin, respectively^[@CR10],[@CR16]--[@CR18]^. Thus, the VHS domain was required but not sufficient for this interaction. We assume that the addition of N-terminal residues of GAT domain to VHS would restore this binding, as has been reported for CIMPR^[@CR19]^. Taken together, similar to other ACLL containing cargoes, EGFR jxt domain is recognized by the GGA2 VHS-GAT domain via interactions involving N108 in the VHS domain.Figure 3GGA2 VHS-GAT recognizes EGFR juxtamembrane (jxt) region. (**a**) Domain structures of EGFR and GGA2 mutants used in the binding assay are shown. Numbers indicate amino acid sequences of20 μm.

GGA1 and GGA3 negatively regulate EGFR protein expression {#Sec6}
---------------------------------------------------------

Previously, GAT domains of GGA1 and GGA3 were shown to interact with ubiquitin^[@CR16],[@CR21],[@CR22]^, and binding of GGA3 to ubiquitinated EGFR reportedly facilitated its lysosomal degradation^[@CR16]^. Therefore, functions of GGA1 and GGA3 in GGA2-depleted cells may be augmented for EGFR degradation. In the present western blotting and immunofluorescence experiments, additional depletion of GGA1 or GGA3 restored EGFR expression in GGA2-depleted cells (Fig. [5a and b](#Fig5){ref-type="fig"}). Moreover, binding assays showed that the EGFR jxt domain was recognized by VHS-GAT from GGA1 and GGA3, and that the interactions were dependent on N92 and N91 residues, respectively, which are responsible for binding to ACLL motifs (Fig. [5c](#Fig5){ref-type="fig"}). In subsequent experiments, influences of GGA1- or GGA3-depletion on the GGA2-EGFR interaction were investigated using PLA. Knockdown of GGA3,


was drastically reduced following GGA2 depletion. To our knowledge, these are the first data to show opposing effects of GGA2 and GGA1/3. Moreover, the present experiments show that all three GGAs interact with the EGFR jxt domain, and that these interactions are dependent on the amino acid that is responsible for recognition of ACLL signals in cargoes. Previous studies have shown that the EGFR jxt domain contains a di-leucine motif at the 679/680 (679-LL) position, which is required for efficient lysosomal degradation of EGFR^[@CR23],[@CR24]^. However, 679-LL does not conform to the consensus ACLL signal (DXXLL) for GGAs due to the lack of an N-terminal acidic residue. Moreover, NMR spectroscopy revealed α-helical structural propensities of these residues, which is distinguished from ACLL that are recognized in extended β orβ-like conformations^[@CR25]^. Therefore, although roles of 679-LL in the interaction of GGAs with EGFR jxt have not been shown, the binding mode may differ from known mechanisms, warranting further studies of additional sites that are involved in this interaction.

Multiple studies have demonstrated that GGA1/3 but not GGA2 recognize ubiquitin^[@CR16],[@CR21],[@CR22]^. Moreover, using crystal structure analyses, Prag *et al*.^[@CR26]^ showed sequence differences in ubiquitin-binding hydrophobic patches on GAT domains of GGA1/3 and GGA2, potentially reflecting the lower affinity of GGA2 than that of GGA1/3. In the present study, EGFR expression in GGA2-depleted cells was restored by additional knockdown of GGA1 or GGA3. Hence, although all three GGAs bind to EGFR jxt domains, GGA1/3 but not GGA2 mediates EGFR degradation. Moreover, *in situ* PLA apparently demonstrated that GGA3 depletion, but unfortunately


the present data indicate that GGA2 together with GGA1/3 might regulate EGFR trafficking in early endosomes/MVBs. Nonetheless, these lines of evidence do not completely exclude the possibility that GGA2-depletion affects other trafficking machineries. More recently, it has been shown that GGA3 promotes recycling of another RTK, Met, from endosomes in association with gyrating clathrin structures^[@CR31],[@CR32]^. It is still an open question if this dynamic structures would be involved in the GGA2-mediated EGFR stabilization.

Finally, we demonstrated GGA2 expression is required for cell growth *in vitro* and in a xenograft model, and that a significant proportion of HCC (\~31%) and CRC cells (\~23%) showed higher levels of GGA2 expression. In agreement, overexpression of EGFR protein has been reported in 40--70% of conventional HCC and 35--50% of CRC patients^[@CR33]--[@CR35]^. However, increasedsent Gutierrez notice of the Court’s intent to dismiss the

appeal unless Gutierrez could show that the order is appealable. Gutierrez did not file any

response. We have found no authority for an appeal from a trial court’s order approving

payment of court-appointed counsel.         Consequently, we dismiss the appeal for lack of

jurisdiction.

August 24, 2016
                                      ANN CRAWFORD McCLURE, Chief Justice

Before McClure, C.J., Rodriguez, and Hughes, JJ.


- 1. Let r be b(-1). Let m be r/9 + (-57)/(-54). Put p, 4, m in ascending order.
p, m, 4
Suppose 0 = -85*x + 40*x. Put x, -2, 4, -5, 17 in increasing order.
-5, -2, x, 4, 17
Let x(v) = -3*v**2 - 117*v + 244. Let y be x(-41). Suppose s - 3*q = 4 + 11, 25 = -4*s - 5*q. Put 2, y, -1, s in descending order.
2, s, -1, y
Let u = -0.439 + 0.097. Let q = -0.042 - u. Let h be ((-18)/(-24))/((-2)/8). Put q, 1, h, 5 in decreasing order.
5, 1, q, h
Let s be -63 - (-8 + -2 + 17). Sort 0, s, 5, -1.
s, -1, 0, 5
Let q = -2449/4896 + 1/4896. Sort q, -2/9, -0.06, -5, 2/5.
-5,-4*d + 2. Let p(u) = -3*u - 35. Let i be p(-13). Put i, 7, d in decreasing order.
7, i, d
Let b be 6/(-30)*3*1*535. Let n = b + 324. Put n, -4, -20, -3 in ascending order.
-20, -4, -3, n
Let s be (1 + 0)*0/40. Sort -3, s, 42, 5 in descending order.
42, 5, s, -3
Suppose 603 = 5*x - i - 38, 4*i = -5*x + 636. Let v = x - 122. Let b = 77 - 81. Sort 3, b, v, 1.
b, 1, 3, v
Suppose 2*p + 41*m = 38*m - 2, 2*p + m - 2 = 0. Sort 255, p, -2.
-2, p, 255
Let m(i) be the third derivative of -i**5/30 + 5*i**4/4 - 29*i**3/6 - 69*i**2. Let w be m(14). Sort


-0.32, f, -5, q in ascending order.
-5, -0.32, f, q
Let c = -2540 + 2536. Sort -2/7, -2/1943, c in descending order.
-2/1943, -2/7, c
Let k = 16715.97 - 16716. Put k, -5, -8.5, 4 in increasing order.
-8.5, -5, k, 4
Let o = -213 + 232. Suppose -7 = -o*n - 83. Let x be 2 + -2 - 1*5. Sort 0, x, n in decreasing order.
0, n, x
Suppose -35*s - 101 + 171 = 0. Sort -4, 7, 4, s in decreasing order.
7, 4, s, -4
Let v(l) = 72*l**3 - 29*l**3 - 9*l**2 - 6*l + l + 3*l**2 - 29*l**3. Let r be v(-1). Put r, 1, 3, 4 in decreasing order.
4, 3, 1, r
Let f = -3.5463 - -3.7463. Sort -7.09, f, 5, -1/2.
-7.09, -1/2, f,communicate back to the view using the network, so you could either have some JS send a request to your view or look into django websockets and channels.
https://channels.readthedocs.io/en/latest/
You could also use ajax or as previously mentioned in this answer use the request module and do e.g. a POST request.


Tuesday, April 15, 2008

April and Matt

Not too long ago, I had the pleasure of photographing April and Matt's wedding. Prior to the wedding, they had scouted out the UCI campus and found some great locations they wanted pictures at. April was so fun, she had no problem getting her dress dirty laying in the tree roots and running through some damp grass!and I grab my crotch
Just move to the rhythm
Im looking at the man in the mirror
and he's looking right back
I got one thing to ask, "Who's Bad?"
Yep, you can't do it like me
Break it down to the "A,B,Cs"
Bad to the bone grab the phone,
Im a smooth criminal You are not alone
It dont matter if ya black or white
Everybody get down when Im on the mic'
And the party dont stop 'till you get enough
'Cause the Far East Movement is dangerous!

[Chorus]

Yo do you remember the time
when we fell in love on the dance flo'
I wanna rock witchu and I just cant get enough
Im in the zone and Im ready to go
Captain EO Im out of this globe
Slip and Slide on ya hips and thighs
and I cant wait to take you


home

Now Im reminiscing all those hugs and kisses on your cheek
dancing to the beat
now wont you be my missus
1983, my Jerry Curls
pants on tight here to rock your world
to get this tight took a lot of practice,
Dance like Micheal Jackson!

you got it right dont stop the party party
move to the side dont stop the party party x2to indicate that the
     * caller doesn't need to specify a field.  Do not subclass.
     */
    enum { DONT_CARE = -1 };

    /**
     * Creates a FieldPosition object with a non-specified field.
     * @stable ICU 2.0
     */
    FieldPosition()
        : UObject(), fField(DONT_CARE), fBeginIndex(0), fEndIndex(0) {}

    /**
     * Creates a FieldPosition object for the given field.  Fields are
     * identified by constants, whose names typically end with _FIELD,
     * in the various subclasses of Format.


    * @stable ICU 2.0
     */
    virtual ~FieldPosition();

    /**
     * Assignment operator
     * @param copy the object to be copied from.
     * @stable ICU 2.0
     */
    FieldPosition&      operator=(const FieldPosition& copy);

    /**
     * Equality operator.
     * @param that    the object to be compared with.
     * @return        TRUE if the two field positions are equal, FALSE otherwise.
     * @stable ICU 2.0
   N. langsdorffii are grown as ornamental plants, often under the name of flowering tobacco. They are popular vespertines (evening bloomers), their sweet-smelling flowers opening in the evening to be visited by hawkmoths and other pollinators. In temperate climates they behave as annuals (hardiness 9a-11).
The hybrid cultivars Domino Series  and 'Lime Green' have gained the Royal Horticultural Society's Award of Garden Merit.

Garden varieties are derived from N. alata (e.g. 'Niki' and 'Saratoga' series) and more recently from Nicotiana x sanderae (e.g. 'Perfume' and 'Domino' series).

The tobacco budworm (Heliothis virescens) has proven to be a massive pest of many species in the genus, and has resisted many attempts at management.

References

Bibliography

  (1999): Nicotiana. Retrieved 2007-11-20.
  (1990): Congenital skeletal malformations and cleft palate induced in goats by ingestion


topic, and I just happen to be interested in these themes. What I wrote here is a summary of what I assume I understood of what I read (even though I'm personally inclined against the people who speaks about what they don't fully understand). In this light, I'd be very pleased if any answer to this question involves a rectification of any assertion which happened to be wrong.
P.S. : this is an exact repost of the question I originally asked at Philosophy .SE, because I assumed this to be an overly philosophical matter, and so it wouldn't be well received by the mathematics community. The lack of response there (be it because I wrong, and this actually makes up a question which can only be answered with aio.ballerinalang.compiler.syntax.tree.ReturnTypeDescriptorNode;
import io.ballerinalang.compiler.syntax.tree.SyntaxKind;

import java.util.Collection;
import java.util.Collections;

/**
 * This is a generated internal syntax tree node.
 *
 * @since 2.0.0
 */
public class STReturnTypeDescriptorNode extends STNode {
    public final STNode returnsKeyword;
    public final STNode annotations;
    public final STNode type;

    STReturnTypeDescriptorNode(
            STNode returnsKeyword,
            STNode annotations,
            STNode type) {
        this(
                returnsKeyword,
                annotations,


 1          1(0.999-1.001)       1.001(0.999-1.002)   1(0.999-1.001)

Model1: Adjusted for age & gender

Model2: Adjusted for age & gender & Creatinin

Model3: Adjusted for age & gender & Cholesterol

Model4: Adjusted for age & gender & Creatinin & Cholesterol

Model5: Adjusted for age & gender & Waist Circumference

Using the lowest quartile of UA level as a reference, crude and adjusted multivariate odd's ratios (ORs) were calculated according to various models. Association between UA level quartiles and MS using logistic regression analysis has been shown in [Table 5](#T5){ref-type="table"}. There were increases in ORs after adjustment for age and gender. After any adjustment for each individual variable in models, the association became insignificant. Cr, Cholesterol and WC were the mostStevens-Johnson syndrome in Thai children: a 29-year study.
Stevens-Johnson syndrome (SJS) is a rare and severe life-threatening hypersensitivity syndrome. The etiology is unclear but is associated with drug exposure or infections and frequently high morbidity and mortality. To determine etiologies, treatments and complications of Stevens-Johnson syndrome (SJS) in children. A retrospective descriptive study was performed at Queen Sirikit National Institute of Child Health during 1979 and 2007 (29-year study). The authors collected and separated data into three phases from 1979 to 1987, 1988 to 1997 and 1998 to 2007. Diagnosis was confirmed by pediatric dermatologists. There were 189 patients, 56 cases between 1979-1987, 72 cases between 1988-1997 and 61 cases between 1998-2007. The ratio of male to female was 1.6: 1. The range of age was from 2 months


MainController. Then, in the last line, we are still creating an Angular Controller but instead of passing it an inline function, we are passing the required MainController file which exports the function, so the result is the same. Of course the syntax changes a little bit, because of the way Angular handles Dependency Injection.

And from there, you can actually have folders like, services or directives. Or if your project is big, you can make folders based on features. For example, if your app features a registration page, you can make a folder named registration which contains a registrationController.js, a registrationTemplate.html and a registrationService.js file. It really depends on how you want to split your app.

This is awesome

With this Gulp and Browserify setup, separating your app into sections (seescientific guidance, indicating that the group has opened up to the evidence-based model that now dominates the medical profession.

Mutual-help groups have long had an instinctive distrust for medical solutions. The history of medical treatment of alcoholism is checkered, at best. The earliest “drugs” prescribed to treat alcoholism were pure quackery. Dr. Leslie Keeley gained fame in the late 19th century with his “double chloride of gold cure,” which he injected into patients four times daily. The injections cured nothing, and a startling number of Keeley cure recipients descended into insanity. Other 19th-century clinicians experimented with morphine, marijuana, and cocaine for the treatment of alcoholism. Early 20th-century physicians tried steroids, again with little benefit, on the theory that a malfunctioning endocrine system was responsible for alcoholism.

As recently as the


and third reviewer (MJR and JLB) were approached when more clarity was needed. Data was extracted on study design, −setting, country, population (age and parity), number of patients included, number of controls, gestational age, BMI, HIV severity (CD4 count), type of ART, type of serum lipids measured, study outcome, pregnancy outcome, serum lipid concentrations and rates of dyslipidaemia in HIV-infected ART recipients and control groups.

Quality assessment {#Sec4}
------------------

Quality of the included articles was scored according to the Cochrane Risk of Bias Tool \[[@CR22]\] (see Additional file [2](#MOESM2){ref-type="media"} for the complete quality assessment). Bias was assessed on the study level, including the selection of the study population, completeness of data, origin of the data (measurements by authors or database research), blinding of the researchers/clinicians, definition of outcome, and confounders. Comparabilitythe incidence of hyperlipidaemia.

Other studies reported the incidence of dyslipidaemia expressed in severity scores of adverse events - Grade I, TC 200 to \<240 mg/dl or TG 150--300 mg/dl; Grade II TC 240 to \<300, TG \>300 to 500; Grade III TC ≥ 300 or TG \>500 to \<1000, and Grade IV TG \>1000 mg/dl -- and mostly found cases of lower grades of dyslipidaemia \[[@CR33], [@CR34], [@CR36], [@CR37], [@CR43], [@CR44]\]. Duran et al. \[[@CR37]\] found dyslipidaemia cases in all treatment groups and two cases (0.6%) hypertriglyceridemia grade II in patients receiving first generation PI nelfinavir. Studies that compared conventional doses of LPV/r to increased doses of LPV/r found higher rates of dyslipidaemia in the increased dose groups \[[@CR33], [@CR34], [@CR44]\]. Ramautarsing et al. \[[@CR36]\] found an incidence of 5% hypercholesterolemia and 5%


beyond the grading of dyslipidaemia, the exact measure of the outcome we were interested in could not be assessed and a meta-analysis on serum lipid concentrations throughout pregnancy could not be performed. The lack of HIV-uninfected control groups in the studies included in this review limited our ability to assess the contribution of HIV-infection to changes in serum lipid concentration during pregnancy and the consequences for pregnancy outcome. The only two studies that compared an HIV-infected to an HIV--uninfected group found lipids to be higher in the uninfected group \[[@CR35], [@CR40]\].

Second, our review is limited by the suboptimal quality of the reported data. No studies mentioned controlling for missing data and only a few studies considered confounders such as age, BMI, dietary patterns, socio-demographics or CD4 count. BMI      return string.Concat(MerchelloConfiguration.ApplicationName, "_AddLocalizationAreas");
        }

        public bool Execute(string packageName, XmlNode xmlData)
        {
            var merchelloFiles = GetMerchelloLanguageFiles();
            LogHelper.Info<AddLocalizationAreas>(string.Format("Merchello Package Acction - {0} Merchello Plugin language files to be merged", merchelloFiles.Count()));

            var merchFileArray = merchelloFiles as FileInfo[] ?? merchelloFiles.ToArray();

            var existingLangs = GetUmbracoLanguageFilesToInsertLocalizationData();
            LogHelper.Info<AddLocalizationAreas>(string.Format("Merchello Package Acction - {0} Umbraco


         return helper.parseStringToXmlNode(xml);
        }

        internal static IEnumerable<FileInfo> GetUmbracoLanguageFiles()
        {
            var di = new DirectoryInfo(string.Format("{0}{1}", RootPath(), UmbracoLangPath.Replace("~", string.Empty).Replace("/", "\\")));
            return di.GetFiles("*.xml");
        }

        internal static IEnumerable<FileInfo> GetMerchelloLanguageFiles()
        {
            var di = new DirectoryInfo(string.Format("{0}{1}", RootPath(), MerchelloLangPath.Replace("~", string.Empty).Replace("/", "\\")));
                // (DoFulfillment is defined later)
        await DoFulfillment(result);
    }
    catch (Exception ex)
    {
        // When the user does not complete the purchase (e.g. cancels or navigates back from the Purchase Page), an exception with an HRESULT of E_FAIL is expected.
    }
}

//
// Fulfillment of consumable in-app products
public async Task DoFulfillment(PurchaseResults result)
{
    var productLicenses = CurrentApp.LicenseInformation.ProductLicenses;

    // Check fulfillment for consumable products with hard-coded asset counts
    await MaybeGiveMeGold(productLicenses["Test1"], 50, result);
}

// Count is passed in as a parameter
async Task MaybeGiveMeGold(ProductLicense license, int goldCount, PurchaseResults result)
{
    if (license.IsConsumable &&


Q:

Grant privileges on future tables in PostgreSQL?

I am running PostgreSQL 9.3.1. I have test database and backup user which is used to backup the database. I have no problems with granting privileges to all current tables, but I have to grant privileges each time the new table is added to schema.
createdb test

psql test
test=# create table foo();
CREATE TABLE
test=# grant all on all tables in schema public to backup;
GRANT
test=# create table bar();
CREATE TABLE

psql -U backup test
test=> select * from foo;
test=> select * from bar;
ERROR:  permission denied for relation bar

Is it possible to grant access to tables which will be created in future without making user owner of the table?

A:

It looks like the solution is to alter default privileges for backup user:
alter default privileges in schema public grant all onto me - why are we doing that at the end? Why don't we have a procedure in place on the front end to vet prosecutions before they can become a conviction?"

St Clair County is an interesting laboratory for such an experiment. A county with a population of about 280,000, it encompasses the city of East St Louis, which at one time led the nation with its murder rate and has struggled since the 1970s with joblessness, drugs and violent crime. There are 32 arresting agencies of all sizes within the county - from a single part-time officer in Summerfield to the 1,700-officer Illinois State Police - who police everything from the urban industrial riverfront on the western border to the corn fields on the eastern edge. It


/**
 * Licensed to Cloudera, Inc. under one
 * or more contributor license agreements.  See the NOTICE file
 * distributed with this work for additional information
 * regarding copyright ownership.  Cloudera, Inc. licenses this file
 * to you under the Apache License, Version 2.0 (the
 * "License"); you may not use this file except in compliance
 * with the License.  You may obtain a copy of the License at
 *
 *     http://www.apache.org/licenses/LICENSE-2.0
 *
 * Unless required by applicable law or agreed to in writing, software
 * distributed under the License is distributed on an "AS IS" BASIS,
 * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 * See the License for the specific language governing permissions and
 *index" v-on:change="completeTask(list)" v-bind:checked="list.isChecked" />

See fiddle:
https://jsfiddle.net/d6encxe1/3/
You should remove the 'id' or use something other than the index of the loop because when you re-order the index doesn't change.

A:

Use a key. A key uniquely identifies an element in Vue. If you do not use a key, Vue will try to re-use existing elements for performance.

To give Vue a hint so that it can track each node’s identity, and thus
  reuse and reorder existing elements, you need to provide a unique key
  attribute for each item. An ideal value for key would be the unique id
  of each item.

You should always use a key when rendering list. Here I'm using the title of your list items, but ideally you should generate a unique key.
<li v-for="(list, index) in


which also protects the woman. The dress completely covers the body of the bride from prying eyes.
At the edges of the dress was sewn in an isosceles triangle, the vertex of which always rested in the corner of the floors. From the triangle, but rather from its base in the directions of the curves denoting fertility. Rhombic shapes on the wedding dress of one stroke symbolized the earth, plants and woman at the same time.

Caps of the bride are also decorated with vegetation of serpentine form, but is added here for the animal ornament. Often on wedding cap embroidered with the heads of peacocks.
Wedding clothes Ossetians are also decorated with braid, braid and gold embroidery. However, jewelry and ornamentally was less than a woman's dress. Male wedding dressthat needs more attention. One recent study suggested that for every new industrial robot installed in a given commuting area, between 3 and 5.6 jobs are permanently lost.

And in the competition for AI supremacy with China — another area of concern for the US — experts are unanimous that the country is in danger of falling behind. This is a particular concern because of the Trump administration’s determination to cut funding for basic scientific research. One expert described the proposed Republican budget plans as “alarming and counterproductive,” while Alphabet chairman Eric Schmidt said earlier this month the US government needs to “get [its] act together” before China overtakes for good.

In her interview, Clinton didn’t discuss any details of specific policies she would like to see enacted, but said


Security and Web Services

What is in essence a framework for designing, developing and building a new generation of applications around web standards and protocols, web services promises to make it far easier to integrate applications across disparate hardware and software platforms - a constant gripe with existing technology. Backed by all of the major IT vendors (Microsoft, IBM, Sun, Oracle, etc.), web services certainly will not suffer from a lack of effort or exposure, but will it take off and what are the issues?

In the wake of the dot-com meltdown, the global economy could be forgiven for slapping a "handle with care" sticker on the latest and greatest thing to emerge from the world of high-tech. The prevailing mood amongst many organizations is one of caution for allthan ever to implement a sound security platform for online business. Authentication and authorization of users, data and devices will be critical to facilitate the seamless aggregation of applications from distinct re-usable components of logic distributed across servers that may or may not be within the organization's protected domain. A variety of authentication and authorization mechanisms for web services are being put forward by the major vendors, such as Microsoft (e.g., Passport) and Sun (e.g., Liberty).

The good news is that these mechanisms are building upon existing proven technologies such as public key digital signatures and certificates, Kerberos and web access control, so it's evolution rather than revolution. The area to watch out for is the degree of standardization of new web services security specifications. Most organizations will be


forced to operate multiple authentication and authorization mechanisms to satisfy the full range of their business risks, but all will want to keep the number of different mechanisms to a minimum. It makes absolute sense therefore to deploy those mechanisms that have the broadest appeal through open standards.

The next 18 months will see major progress on firming up of standards such as the XML key management specification (XKMS), which will cover the registration and distribution of XML-based public keys to encrypt and decrypt documents, and the associated XBULK standard for bulk key registration (which is of particular importance in areas such as smartcards and mobile devices). Other emerging web services standards include the XML encryption standard, which will govern the encryption and decryption of digital content such asXML documents, the XML digital signature standard (XML-DSig), which will define how to digitally sign an XML document, and the security assertions markup language (SAML), which allows users to maintain their authentication and entitlement credentials over multiple web sites. You should insist on strong support for web services security standards from your vendors in their forthcoming product releases.

Concerns over security issues with SOAP (the web services transport layer) are also being addressed through an initiative called WS-Security, which has been jointly developed by Microsoft, IBM and Verisign, and describes how to protect SOAP messages using the underlying XML encryption and digital signature standards. In essence, it is assumed that the WS-Security layer will be able to connect seamlessly to a suite of web-based security services for the required


Brother's role forces exit of Blackwater investigator

November 15, 2007|By David Wood | David Wood,Sun Reporter

WASHINGTON -- Howard Krongard, the embattled State Department inspector general who is accused of blocking investigations into security contractor Blackwater Worldwide, abruptly recused himself from all Blackwater inquiries yesterday after a congressional panel confronted him with evidence that his brother is serving on a company advisory board.

The spreading Blackwater scandal involves allegations that its armed security guards, under contract to the State Department to guard diplomats in Iraq, killed at least 17 Iraqi civilians in Baghdad in September. The results of an FBI investigation, which reportedly found that the Blackwater guards acted rashly and without obvious provocation, are under review at the State Department.

Krongard's elder brother, A.B. "Buzzy" Krongard, was chief executive of Alex.Brown & Sons in Baltimore before serving in the No. 3 position at the CIA.

Testifying under oath before the House Oversight and Government Reform Committee yesterday, Howard Krongard at first denied as an "ugly rumor" that his brother had any financial interest or position with Blackwater. "I specifically asked him," Krongard insisted.

But Rep. Elijah E. Cummings, a Baltimore Democrat, produced a letter from Blackwater chairman Erik Prince asking "Buzzy" Krongard to serve on the firm's advisory board.

When Howard Krongard disputed it, Cummings went on, producing an e-mail sent from Blackwater to his brother, dated Sept. 5, that said, "Welcome and thank you for accepting the invitation to be a member of the board."

Cummings also observed that the Blackwater board was meeting in Williamsburg, Va., this week, "as we


1. Field of the Invention
Embodiments of the present invention generally relate to computer management and, more particularly, to scheduling backups or virus scans in a computer system.
2. Description of the Related Art
Backup operations are regularly performed within an enterprise computing environment to protect data stored on network computers. Although networks regularly backup data on system servers, the numerous client computers residing in the network must also be backed up. However, performing backup operations for client desktop and laptop computers can prove to be a challenging endeavor since desktops are frequently shut down during periods on non-use (e.g., non-business hours) and laptop computers are often disconnected from the network for extended periods of time (e.g., when used during travel). However, backup operations may significantly hinder the operation of athe beam-constrained mass of the candidate, defined as $$M_{bc} \equiv \sqrt{E_{\rm beam}^{2}  - \vec{p}^{2}_{\rm cand}},
\label{eq:Mbc}$$ and the energy difference between the beam and the candidate, defined to be $$\Delta E = E_{\rm beam} -E_{\rm cand}.
\label{eq:DeltaE}$$ The remaining observable tracks are then reconstructed to form the daughter meson. The missing energy, $E_{\rm miss}$, and missing momentum, $|\vec{p}_{\rm miss}|$, in the event are used to form the kinematic variable $U\equiv E_{\rm miss} - |\vec{p}_{\rm miss}|$, which is fit to determine the signal and background contributions. These distributions and fits are shown in Fig. \[fig:d0exsemi\] and Fig. \[fig:dplusexsemi\] for the neutral and charged $D$ meson modes, respectively.

These raw numbers of events are corrected for efficiency and divided by the number of tag $D$ mesons to produce absolute branching fractions. The efficiencies


                       $8.71 \pm 0.38 \pm 0.37$       $6.7\pm 0.9$

  $D^{+}\rightarrow K^{*0}(K^{-}\pi^{+})e^{+}\nu$                  $5.70 \pm 0.28            $5.5\pm 0.7$
                                                        nearest 100000.
6200000
Round -1.104 to one dp.
-1.1
What is -199450 rounded to the nearest 1000?
-199000
Round -0.0012677 to five dps.
-0.00127
What is 0.00002769 rounded to five decimal places?
0.00003
Round -0.0000045468 to seven dps.
-0.0000045
What is -3.21 rounded to 0 dps?
-3
What is 28124000 rounded to the nearest one million?
28000000
Round 1.66309 to two decimal places.
1.66
What is -47852.1 rounded to the nearest one hundred?
-47900
What is -0.0026654 rounded to 4 decimal places?
-0.0027
What is 0.0000076965 rounded to 7 decimal places?
0.0000077
Round -0.18111 to 2 decimal places.
-0.18
What is 1.8806 rounded to one dp?
1.9
Round 517 to the nearest 100.
500
Round -24120 to the nearest one thousand.
-24000
Round 18303000 to the nearest one million.
18000000
What is 208910 rounded to the nearest one thousand?
209000
What is 2634300 rounded to the nearest ten thousand?
2630000
What is -114.382 rounded to the nearest ten?
-110
Round -12985 to the nearest 100.
-13000
Round -18.18 to the


            ORDER

       On August 31, 2012, this Court resolved several discovery disputes. U.S. v. Kellogg,

Brown & Root Servs., Inc., __ F.R.D. __, 2012 WL 3776708 (D.D.C. 2012) (ECF Nos. 116,

117). That Opinion indicated that defendant Kellogg, Brown & Root (“KBR”) is entitled to

limited discovery on force protection matters relating to the parties’ LOGCAP III agreement.

U.S. v. KBR, 2012 WL 3776708 at *10–*12. The Court ordered the parties to meet and confer,

over the following thirty days, to discuss the scope and schedule for this additional production.

See id. at *18. The Court ordered the parties, after these thirty days, to apprise the Court of their

progress and ask for an extension if necessary. Id.

the remaining discovery issues. A joint Status Update, filed electronically with the

Court, will suffice. If the parties come to a compromise, they shall inform the Court of the

agreement struck and propose a schedule for accomplishing the additional discovery. If the

parties cannot come to an agreement, they may ask the Court for additional time or ask the Court

enter an Order to Compel.

       IT IS SO ORDERED

       Signed by Royce C. Lamberth, Chief Judge, on October 1, 2012.


that they had history, but she wanted proof." "Ah." "Burn notice!" "You just sit there and look pretty, actually." "So I was thinking after dinner, we could take some muscle relaxers and swim out to that new karaoke barge." "Well, I see no downside to a long night swim without muscle control." "You sure, Jack?" "It starts at midnight." " It starts at midnight?" " Ugh." "I know, it's stupid early, but maybe after we can shotgun some beers on the L." "Or make out in the back of a Korean revival church, or get naked and roll around on the front lawn of the original Home Alone house." "Do you want to do any of that?" "Yeah, Jack." "Do you want to do any of that?" "Okay,the one who's supposed to be shared." "It all used to be so much simpler, didn't it?" "When only men were allowed to sleep around." "Though it makes you wonder, if only men were sleeping around, who were they sleeping with?" "I'm gonna write that down in my book. [chuckles]" "Roland with the Punches. [giggles]" "I-I'm starting to wonder if maybe I could stand a little commitment." "Jack, it's finally happened." "You've disappointed me." "When I was your age," "I was cleaning up with younger women." "And you should be, too." "You have maturity, you have experience, you have wealth..." "I don't have wealth." "That still mystifies me." "How can you be nearly 40 and still be poor?" "You know what you pay me." "Oh, yes, of course."


totes down with this open relaysh." "Did you just use the words "totes down" and "open relaysh"?" "Jack, I think you're losing your damn mind." "Clark, come over here." "I need you to be my wingman." "And there it goes." "All right, so where should we start, playa?" "She's hot." "EMMA:" "Ooh, good choice." "Jenna's a total comet." ""Comet." Noun." "Someone who has sporadic but intense hookups." " It's also an abrasive cleaner." " Mm." "But just know, she's in a throuple with that guy Eric and..." " Oh." "Kaylie." " Oh." " What?" " Oh." ""Throuple" is a new term that means three people in a couple." "In the '80s, it was known as my mom, Brett, and Doug." "Yeah, I know what a throuple is." "But,cupid or sex Rudolph or some other dumb phrase you whimsical maniacs just made up?" "!" "And why haven't you introduced me to your friend, Molly?" "!" "She seems great!" "Look, Jack, I really like you, but I'm just not really looking for anything serious right now." "Those are my words!" "They're mine!" "And I'm the party sub!" "Me!" "How am I not enough for you?" "Doesn't anyone here want to grow old in a throuple with me?" "!" "I-It's okay, everyone. [chuckles]" "In no way is this a glimpse into your future." "Keep drinking!" "You'll be young forever!" "Oh, Jack, you're finally awake." "How long was I out?" "18 hours, and one and a half Sharpies." "Yes, I'm afraid I can never really resist a good prank."


Q:

BizTalk WCF-WebHttp adapter Client Certificate not found

When configuring the WCF-WebHttp security tab, I have set Security Mode to Transport, Client Credential type to Certificate.
When I go to browse for Client Cert, it comes up with the only options being Current User/My Store instead of Local Machine/Address Book. So, to see what happens, I imported my cert into the Current User/My Store. This worked fine and I imported the same cert into the Service Certificate tab. When a message is processed through the send port, an error like so occurs:

Cannot find the X.509 certificate using the following search criteria: StoreName 'My', StoreLocation 'CurrentUser', FindType 'FindByThumbprint', FindValue 'EF742FBAF0A13A7BEA859DC573308D52F0611CDB'.

When it tries to do a GET to the REST service we are trying to consume.
The configuration I'm using looks like so:

I'mone number $\theta
^{12}=\theta $ and the multiplication is specified by the relation

$$U_{1}U_{2}=e^{2\pi i\theta }U_{2}U_{1}$$

where $U_{\alpha }=U_{\overrightarrow{e_{\alpha }}}$ are elements $U_{%
\overrightarrow{n}}$ corresponding to vectors of standard basis $%
\overrightarrow{e}_{1}=(1,0)$, $\overrightarrow{e}_{2}=(0,1)$.

In the case when $\theta $ is a natural number $T_{\theta }^{2}$ is isomorphic to the algebra of smooth functions on the commutative two-dimensional torus. We will consider projective modules over $T_{\theta
}^{2}$ (we always assume that our modules are finitely generated; a projective module is by definition a direct summand in a free module $%
(T_{\theta }^{2})^{k}$). We assume that the number $\theta $ is irrational; in this case every projective right module over $T_{\theta }^{2}$ is isomorphic to one of the modules $E_{n,m}$ defined in the following way (see [@Co2], [@Co3], [@Ko3]). The elements of $E_{n,m}$ are functions on the Schwartz


account that a constant curvature connection on $E_{n,m}$ is a constant curvature connection on the bimodule, one can define a notion of complex structure and of holomorphic vector for a bimodule. More precisely, complex structure on $T_{\theta }$-module $E_{n,m}$ induces a complex structure on same space considered as left $T_{\theta ^{\prime }}$-module in such a way that the notion of holomorphic vector remains the same. These two complex structures specify a complex structure on a bimodule; the notion of holomorphic vector in a bimodule coincides with corresponding notion for both modules. If ${\cal E}^{\prime }$ is a complex $(T_{\theta ^{\prime}},T_{\theta })$-bimodule, ${\cal E}^{\prime \prime }$ is a complex $(T_{\theta },T_{\theta ^{\prime \prime }})$-bimodule, then the $(T_{\theta
^{\prime }},T_{\theta ^{\prime \prime }})$-bimodule ${\cal E}={\cal E}^{\prime }\underset{T_{\theta }}{\otimes }{\cal E}^{\prime \primenight, the Cavs took care of business against the Warriors, and "The Diff" was perpetually in double-digits. Clearly, that pump-up music had inspired the boys, and, in the words of one particularly impressed fan, "I haven't seen a 'Diff' that large since my first divorce!"

I hope the Diff makes its way to Jacobs Field soon, because figuring out how many runs the Indians have to make up when they're down 3-1 is just too much work for me. Answering your Tribe-related questions, on the other hand, is a labor of love, so let's get to it.

Last week you talked about the final two bullpen spots. What do you see for the final two position-player spots? Will the Tribe go with more infield depth, power or speed? -- Matt


with DirecTV, and my inbox is already filling up with readers who find this to be a troubling development.

For those unable or unwilling to subscribe to DirecTV, the MLB.TV option would still be available. That doesn't do much for those who like to watch the games on their 63" plasma screens, but it's
a way for out-of-market fans to see their team play.

One more semi-related note on this: I get frequent e-mails from Indians fans in Buffalo who are ticked off about not having access to Tribe telecasts on SportsTime Ohio. It seems
that Dish Network is the only provider that carries STO in the Buffalo market (which is within the Indians' territorial TV rights), while DirecTV has chosen not to.

For what it's worth, Ed Niemi, the vice president ofand inflammatory pain.
Neuropathic pain is pain caused by damage or disease that affects the somatosensory system. Neuropathic pain is originated from spontaneous ectopic neuron discharge in the nervous system either in central or in peripheral. Because the underlying etiologies are usually irreversible, most neuropathic pain are chronic pain. Most people describe neuropathic pain as shooting, burning, tingling, lancinating, electric shock qualities, numbness, and persistent allodynia. The nomenclature of neuropathic pain is based on the site of initiating nervous system with the etiology; for examples, central post-stroke pain, diabetes peripheral neuropathy, post-herpetic (or post-shingles) neuralgia, terminal cancer pain, phantom limb pain.
Mix-type pain is featured by the coexistence of both nociceptive and neuropathic pain. For example, muscle pain trigger central or peripheral neuron sensitization leading to chronic low back pain,


sort of management position, or go into TV color commentary," Goodwin said.

Payton, who turned 39 this summer, was not available for comment.

Goodwin said there have been no talks yet with potential teams, including the Warriors.

"He definitely has thoughts of going backfrom Sports 1

and giving it one more shot in Miami," Goodwin said. "If that didn't work, he'd like to play for a West Coast team, the Warriors being one of them. It'd be great to retire in Oakland."

The Warriors currently have no roster room, with the maximum 15 players signed to guaranteed contracts headed into training camp next month.

Payton, a nine-time NBA All-Star point guard and one of the league's greatest defensive players during his prime, grew up in Oakland and starred at Skyline High.

Payton played the past... must at some point give way not just to a neutral stance, which we expect by 2020, but to a tightening of fiscal policy that could restrict growth," Hatzius wrote.

Finally, the economist explained that regardless of how much longer the current expansion persists, increasing deficits and debts naturally put upward pressure on interest rates, expanding the deficit further.

According to estimates by Goldman Sachs, a 1 percentage point increase in the budget deficit raises the 10-year Treasury yield by roughly 20 basis points when the economy is at or beyond full employment, as it appears to be currently.

"Surprises are clearly possible in both directions, but we believe the risks are tilted in the direction of larger deficits than projected," Hatzius concluded. "While we expect Congress will eventually address


which was then placed on a telemetry receiver for 2 h, and the rat quickly awakened from the anesthesia. These chambers were used in place of the rats' home cages since they were taller in size and therefore minimized the risk of dislodgment of the device from the back of the rat, particularly when the animal was awakening from anesthesia and moving around the cage. Thereafter, arterial pressure, heart rate, and locomotor activity recordings were scheduled to be continuously recorded. At the end of the 2‐h recording period, rats were lightly anesthetized and the device was removed. The acquired data were subsequently analyzed using NIC‐Kidney device partner software (MPDlab v1.0, Mannheim Pharma & Diagnostics GmbH). The software generates the elimination kinetics curve of FITC‐sinistrin from which elimination half‐life determinationsfor simultaneous measurement of arterial pressure and GFR. This consequently allowed us to perform within‐animal comparisons of arterial pressure across time. Furthermore, we administered FITC‐sinistrin during the anesthesia period. Thus, we were able to ascertain the impact of the GFR protocol on MAP, heart rate, and locomotor activity with a shorter recovery time (\~45 min). Of course, it cannot be ruled out that compensatory mechanisms are activated during the brief period of light isoflurane anesthesia, such as the renin--angiotensin system, that subsequently contribute to the normalization of arterial pressure during the GFR measurement period, which could also affect GFR. It would therefore be of interest in future studies to compare plasma renin activity at baseline and at the commencement of the GFR measurement period. If differences in plasma renin


and more can be added using the option. But, keep an eye out under the "What's On Your Mind" status to see if you got the new update. In recent years, the personal content of Facebook has waned and made way for more advertisements, memes, links and cooking videos.

Accoding to TechCrunch, the feature is being rolled out gradually, and may not immediately reflect for you. Facebook will display the list in a neat and tidy colour image.

In its continued push for more meaningful interactions on its platform, Facebook Inc.is rolling out a new feature that will allow for more personal posts from users.

You'll soon find the new option to create a list in your status update box at the top of your Facebook feed.

To encourage constructive conversations, Facebook2)
			v |= 0x00000100;
		if (nibbles & 4)
			v |= 0x00010000;
		if (nibbles & 8)
			v |= 0x01000000;
		nibbles >>= 4;

		wrl(mp, off, v);
	}

	wrlp(mp, PORT_CONFIG, port_config);
}

static int addr_crc(unsigned char *addr)
{
	int crc = 0;
	int i;

	for (i = 0; i < 6; i++) {
		int j;

		crc = (crc ^ addr[i]) << 8;
		for (j = 7; j >= 0; j--) {
			if (crc & (0x100 << j))
				crc ^= 0x107 << j;
		}
	}

	return crc;
}

static void mv643xx_eth_program_multicast_filter(struct net_device *dev)
{
	struct mv643xx_eth_private *mp = netdev_priv(dev);
	u32 *mc_spec;
	u32 *mc_other;
	struct dev_addr_list *addr;
	int i;

	if (dev->flags & (IFF_PROMISC | IFF_ALLMULTI)) {
		int port_num;
		u32 accept;

oom:
		port_num = mp->port_num;
		accept = 0x01010101;
		for (i = 0; i < 0x100; i += 4) {
			wrl(mp, SPECIAL_MCAST_TABLE(port_num) + i, accept);
			wrl(mp, OTHER_MCAST_TABLE(port_num) + i, accept);
		}
		return;
	}

	mc_spec = kmalloc(0x200, GFP_ATOMIC);
	if (mc_spec == NULL)
		goto oom;
	mc_other = mc_spec + (0x100 >> 2);

	memset(mc_spec, 0, 0x100);
	memset(mc_other, 0, 0x100);

	for (addr = dev->mc_list; addr != NULL; addr =


NET_SKB_PAD is smaller than a cache line,
	 * netdev_alloc_skb() will cause skb->data to be misaligned
	 * to a cache line boundary.  If this is the case, include
	 * some extra space to allow re-aligning the data area.
	 */
	mp->skb_size += SKB_DMA_REALIGN;
}

static int mv643xx_eth_open(struct net_device *dev)
{
	struct mv643xx_eth_private *mp = netdev_priv(dev);
	int err;
	int i;

	wrlp(mp, INT_CAUSE, 0);
	wrlp(mp, INT_CAUSE_EXT, 0);
	rdlp(mp, INT_CAUSE_EXT);

	err = request_irq(dev->irq, mv643xx_eth_irq,
			  IRQF_SHARED, dev->name, dev);
	if (err) {
		dev_printk(KERN_ERR, &dev->dev, "can't assign irq\n");
		return -EAGAIN;
	}

	mv643xx_eth_recalc_skb_size(mp);

	napi_enable(&mp->napi);

	skb_queue_head_init(&mp->rx_recycle);

	mp->int_mask = INT_EXT;

	for (i = 0; i < mp->rxq_count; i++) {
		err = rxq_init(mp, i);
		if (err) {
			while (--i >= 0)
				rxq_deinit(mp->rxq + i);
			goto out;
		}

		rxq_refill(mp->rxq + i, INT_MAX);
		mp->int_mask |= INT_RX_0 << i;
	}

	if (mp->oom) {
		mp->rx_oom.expires = jiffies + (HZ / 10);
		add_timer(&mp->rx_oom);
	}

	for (i = 0; i < mp->txq_count; i++) {
		err = txq_init(mp, i);
		if (err) {
			while (--i >= 0)
				txq_deinit(mp->txq + i);
			goto out_free;
		}
		mp->int_mask |= INT_TX_END_0 <<  struct mbus_dram_target_info *dram)
{
	void __iomem *base = msp->base;
	u32 win_enable;
	u32 win_protect;
	int i;

	for (i = 0; i < 6; i++) {
		writel(0, base + WINDOW_BASE(i));
		writel(0, base + WINDOW_SIZE(i));
		if (i < 4)
			writel(0, base + WINDOW_REMAP_HIGH(i));
	}

	win_enable = 0x3f;
	win_protect = 0;

	for (i = 0; i < dram->num_cs; i++) {
		struct mbus_dram_window *cs = dram->cs + i;

		writel((cs->base & 0xffff0000) |
			(cs->mbus_attr << 8) |
			dram->mbus_dram_target_id, base + WINDOW_BASE(i));
		writel((cs->size - 1) & 0xffff0000, base + WINDOW_SIZE(i));

		win_enable &= ~(1 << i);
		win_protect |= 3 << (2 * i);
	}

	writel(win_enable, base + WINDOW_BAR_ENABLE);
	msp->win_protect = win_protect;
}

static void infer_hw_params(struct mv643xx_eth_shared_private *msp)
{
	/*
	 * Check whether we have a 14-bit coal limit field in bits
	 * [21:8], or a 16-bit coal limit in bits [25,21:7] of the
	 * SDMA config register.
	 */
	writel(0x02000000, msp->base + 0x0400 + SDMA_CONFIG);
	if (readl(msp->base + 0x0400 + SDMA_CONFIG) & 0x02000000)
		msp->extended_rx_coal_limit = 1;
	else
		msp->extended_rx_coal_limit


Association Between Diverticular Disease and Abdominal Aortic Aneurysms: Pooled Analysis of Two Population Based Screening Cohorts.
The aetiology of abdominal aortic aneurysms (AAA) is multifactorial, and many risk factors are shared with diverticular disease. It is unknown whether an independent association exists between these conditions. Individuals enrolled in two Danish population based randomised AAA screening trials and assigned to cross sectional screening and evaluation of cardiovascular risk factors were identified. Diagnoses of diverticular disease were interrogated from a national patient registry covering the period from 1977 to the screening date. Adjusted odds ratios (aOR) and hazard ratios (aHR) with 95% CI were calculated as risk measures. 24,632 individuals (median age, 69 years) were included. At screening, 687 patients had pre-existing diverticular disease. Patients with diverticular disease were more likelysuitable sources of Si, Al and structure directing agents such as alkali metals, alkaline earth metals, amines, or organoammonium cations. The structure directing agents reside in the pores of the zeolite and are largely responsible for the particular structure that is ultimately formed. These species balance the framework charge associated with aluminum and can also serve as space fillers. Zeolites are characterized by having pore openings of uniform dimensions, having a significant ion exchange capacity, and being capable of reversibly desorbing an adsorbed phase which is dispersed throughout the internal voids of the crystal without significantly displacing any atoms which make up the permanent zeolite crystal structure. Zeolites can be used as catalysts for hydrocarbon conversion reactions, which can take place on outside surfaces as well as on


particular XRD pattern in the absence of any nitrogenous organic agent and in the presence of ethanol. The UZM-53 of the instant invention is synthesized in the presence of two nitrogenous organic agents and in the absence of ethanol.
Zones describes SSZ-32 in U.S. Pat. No. 5,053,373 in the as-synthesized and anhydrous state as having a characteristic XRD pattern, a SiO2/Al2O3 ratio of from 20 to less than 40 and comprising an N-lower alkyl-N′-isopropyl-imidazolium cation such as N,N′-diisopropylimidazolium cation. As prepared, the SiO2/Al2O3 ratio is typically from 25:1 to about 37:1 and can be increased by treating the zeolite with chelating agents or acids to extract aluminum from the zeolite lattice.
Zones and coworkers describe in U.S. Pat. No. 7,390,763 the preparation of SSZ-32X, a MTT zeolite of a certainreally emotional about crime.

While speaking to a bunch of sheriffs Tuesday, Trump insisted America's murder rate is "the highest it’s been in 47 years." Which isn't even remotely true -- it wasn't true when Trump said it, and it wasn't true when Kellyanne Conway refused to give Jake Tapper a straight answer about it the next day. In mere reality, murder rates are down precipitously since the 1990s:

So does it matter that the president of the United States can't master a fairly simple fact like that (and then complained that the media isn't covering it)? Heck no, Santorum cheerfully explained to Poppy Harlow, because everyone surely agrees that crime is a bad thing, right?

Sure, sure, crime may be down -- thanks mostly to Rudy Giuliani, Santorum burbled. "But


it was only a mass school shooting, and that's not what he was talking about anyway:

You know as well as I do, Jim, when there was white-on-black crime, the president was all over it, and when it was a black-on-white crime, that was simply not the case, and so this is not something new.

Santorum went on to explain that since President Trump is really worried about all the Radical Islamic Terror out there, he really can't be expected to mention some incident where a white supremacist shoots a bunch of Muslims, now can he? You have to pick and choose the human lives you care about, and it's certainly not Donald Trump's fault that Barack Obama set such a poor example for future presidents to follow.

Rick Santorum mayBaltimore Ravens superhuman kicker Justin Tucker is unaffected by this trend. He seems to go out of his way to take a practice kick when the ball is snapped and is 4 for 5 when taking a practice kick with his only miss coming from 65 yards. I guess it makes sense that the outlier, in this case, happens to be one of the best kickers of all time.

Icing in College Football

When comparing icing in the NFL to the college game, the overall numbers differ slightly. In looking at the 2018 season in which at least one FBS team was a part of the game, the overall field goal percentage was 71.5 percent. Even when looking at just the clutch situations (final 3:00 of the second/fourth quarter and


It's time to meet Zoom's other maniacal and murderous alter ego!

On tonight's all-new episode of The Flash, the truth about Jay Garrick's real identity will send shockwaves through the series -- and only ETonline has your exclusive sneak peek of Zoom's jaw-dropping backstory.

We're displeased to introduce Hunter Zoloman -- aka Jay Garrick, Zoom, and the best TV villain we've seen in years!

EXCLUSIVE: 'Arrow' Boss Reveals 4 Reasons Why Laurel Was Killed!

With his wild hair and soul-piercing eyes, Wells reveals that the mad men is "instantly recognizable" to the people of Earth 2. "On my Earth, serial killers are an anomaly so there's a lot of media attention," he explains.

(With that kind public frenzy, it seems a little bizarre that no one would recognize the facial similarities between Jaynontransgenic pBPC, both in SM. E60 pBPC is in blue, and E45 pBPC is in red. (B) Quantitative real-time PCR analysis of select progenitor and differentiation markers between the E60 pBPCs in SM and E45 pBPCs in SM. Data are normalized to E45. Values greater than 1 indicate higher expression in E60 cells and values less than 1 indicate higher expression in E45 cells. The reference line at Relative Quantification (RQ) = 1 indicates no fold change difference. \**P* \< 0.05 for E60 versus E45. SM, standard medium; pBPC, pig brain progenitor cells; PCR, polymerase chain reaction; pBPCs, pig brain progenitor cells.](10.1177_0963689717723015-fig2){#fig2-0963689717723015}

E45 BPCs Grown in UltraCulture-Based Medium versus SM {#section12-0963689717723015}
-----------------------------------------------------

Since there were no observed large-scale changes in the gene expression profile between the E45 *GFP* transgenic and nontransgenic


such as *MBP*, *TBR1*, and *OMG* ([Table 2](#table2-0963689717723015){ref-type="table"}), as were all lineage markers from the qPCR analysis, particularly *CLDN11*, *GFAP*, and *KLF4*. The nominal upregulation of several cell cycle--related genes would suggest that UL promotes higher cellular proliferation in comparison to other culture media, which has been observed in adipocyte progenitor cells of porcine and other similar mammalian species (Schwarz et al., 2012),^[@bibr33-0963689717723015]^ and we have observed similar long-term proliferation of feline neural progenitor cells under similar culture conditions (Yang et al., 2012).^[@bibr34-0963689717723015]^ The significance of increased expression of *CXCR4* is less straightforward since this gene is both a marker on neural progenitor cells^[@bibr36-0963689717723015]^ and yet also increases in expression during the course differentiation, at least in vitro.^[@bibr35-0963689717723015]^ As a serum-free medium, UL is beneficial over serum-containing media,(2) assess the effect of pigeonpea
cropping systems and residue management on soil aggregation and soil water content. The study
was conducted at Katumani Research Centre for three seasons. Intercropping cereals with short
duration pigeonpea varieties depressed both pigeonpea grain and N yield. Cropping systems also
influenced accumulation of P in yield components of maize and pigeonpea. However, there were
no major changes in soil C, N and P. Soil macro- and micro-aggregates were affected by
cultivation and cropping systems. Cultivation reduced macro-aggregation but increased microaggregation.
Soil water content increased across cropping systems with increase in residue
application rate. Thus, pigeonpea cropping systems have the potential to enrich or deplete the
soil, depending on the management.


Dubai Culture & Dubai Traditions

Before visiting Dubai, it is a good idea to familiarise yourself with
the cultures, traditions and customs to make your trip a pleasant one
and one where do not end up in an embarrassing situation.

One must remember that Dubai s a muslim country and Islam is the national
faith. One must ensure that offence is not caused and therefore below
are a few of the traditions and customs in Dubai that we would recommend
that you adhere to.

Dress Modestly: It is advised that women do not wear
any skirts that are higher up than the knees. Tops should not be too
revealing as this could cause offence and embarrassment if the police
get involved. In an ideal scenario, an ankle length skirt would be good
and a modest top.

Men are advised to also[2 cases of chylothorax caused by catheterization of left large venous trunks].
The authors present two cases of almost certain catheterization of the thoracic duct, by infusion catheters placed in the large veins at the base of the neck (once in the left internal jugular, once in the left subclavian). Their clinical manifestaztions are the existence of a rapidly progressive pleural effusion, apart from the abnormal course of the catheter. Removal of the catheter is sufficient to lead to the disappearance of the symptomatology, so that it is difficult to speak of an accident as such, but rather of an incident. These incidents could be avoided by systematic radiography from the time that the catheter is placed in position or the positioning of the latter under control by brilliance


not for patients to request.

~~~
briandear
Going to disagree with you. Doctors often have incentives to prescribe certain
drugs over others that aren’t necessarily the best drug. If it’s legal to
advertise to physicians then it should be legal to advertise to consumers.
Ultimately the consumer is in charge of their own health and should have a say
in their drug choices.

Let’s think of another industry — tires. Is a consumer typically an automotive
engineer or a mechanic? Then why should it be legal to advertise tires to
consumers? Ultimately a mechanic will have to install the tires. However, that
certainly shouldn’t preclude a consumer making their preferences known. With
meds, a doctor can always say no — and they should and do if it isn’t
indicated for the particular affliction.

The idea that consumers need to be shielded fromtemporary accounts, this may
be explanation why ICOs aren't banned too: they ban, but new ads are posted
again and again.

~~~
oculusthrift
i always see the scammiest ads on instagram (free yeezy'z)

------
whataretensors
We've created a generation of people who will do anything they are told to do.
Now these big corps and governments feel like they have to baby-proof the
world because we've created a bunch of lemmings who will give all their money
to an ICO because a banner told them to.

~~~
wslh
> we've created a bunch of lemmings who will give all their money to an ICO
> because a banner told them to.

It is a problem of basic finance education which should be part of the school
curriculum. People also buy a lot of stuff they don't need or include false
claims because a banner told them


to.

~~~
jrwiegand
I was just saying this the other day. I have been a steep learning curve about
retirement accounts, mortgages, etc. There should really be a financial
curriculum in high school, possibly all four years. This is basic information
that everyone should be aware of.

~~~
oculusthrift
isn't there some personal responsibility to teach yourself these things and
not be stupid? Why do government funded schools have to teach people
everything? And what subject will we cut to teach these things?

~~~
CaptSpify
Couldn't that same argument be used against anything we currently teach in
school?

The obvious answer to your first question is: It has severe detrimental
effects to our society, and we'd all be better off if people were taught the
basics.

------
krrrh
Finally James Altucher can go back to doing what he does best.

~~~
chabes
Underrated comment.

------
BenGosub
Why only mention cryptocurrencies in the title? There aretest series showed 95-100% for acute cases. While for chronic cases, test series A and F demonstrated sensitivities at 73.3% and 72.7% respectively. Other series were all below 70%. Negative reversion rates for sera from cured cases within 1 year post-treatment were below 33.3%, those within 2 years were 60% for Series E, while below 50% for all others except the Series H which was excluded due to an extremely low sensitivity obtained. The low values of these test series for chemotherapy assessment may be attributed to the poor specificity of the detecting systems used and/or the sample donors being not totally cured. It is strongly indicated that all the 8 test systems involved in the present study should further be improved in sensitivity, specificity as well as


zooming system. In the zoom lens, the first and second lens groups move along the optical axis to perform a zooming with the third lens group fixed. However, this may change the overall length of the optical system and attain a zoom ratio of only about 2×.
The zoom lens disclosed in Japanese Patent Application Laid-open No. PYUNG 5-173071 comprises, in order from the object side, a first lens group having a negative refractive power, a second lens group having a positive refractive power, a third lens group having a negative refractive power, and a fourth lens group having a positive refractive power. The respective lens groups are moved while zooming, so the configuration of the lens barrel is too complex.
The zoom lens disclosed in Japanese Patent Application Laid-openEarly Postoperative Results of Percutaneous Needle Fasciotomy in 451 Patients with Dupuytren Disease.
Percutaneous needle fasciotomy is a minimally invasive treatment modality for Dupuytren disease. In this study, the authors analyzed the efficacy and complication rate of percutaneous needle fasciotomy using a statistical method that takes the multilevel structure of data, regarding multiple measurements from the same patient, into account. The data of 470 treated rays from 451 patients with Dupuytren disease that underwent percutaneous needle fasciotomy were analyzed retrospectively. The authors described the early postoperative results of percutaneous needle fasciotomy and applied linear mixed models to compare mean correction of passive extension deficit between joints and efficacy of primary versus secondary percutaneous needle fasciotomy. Mean preoperative passive extension deficits at the metacarpophalangeal, proximal interphalangeal, and distal interphalangeal joints


found some Indonesian-manufactured Pantene PRO-V, but considering the price and limited availability, have forbidden him to touch it.)

I can’t tell you where this product was made. No, really, I can’t. That information, if it is there at all, is in a language I do not recognize. What I can tell you, thanks to the company’s fine interpreters, is that this particular bottle is of the following variety: “Ocean Element Beauty fair.” Where my Pantene bottle says “Smooth & Silky,” this bottle of mystery goo goes on to say, “Nourishment Moisture, Twinkling of Hair.”

Now, I ask you, who wouldn’t want Twinkling of Hair? These people have secured a corner in a very competitive market.

Paul chuckled and was satisfied with this, and knowing that it couldn’t be all bad tofive assists and 10 points, while Florek has five, four, and nine, respectively.

The Wildcats have been scoring more goals in the third period than in either of the first two stanzas and are outscoring their opponents 14-11 in the third period. The ‘Cats have eight goals in each of the first two periods in the 2010-11 season. The ‘Cats have allowed 14 first period goals and 11 second period goals.

The ‘Cats continue to be out-shot by their opponents (440-351) and have scored 30 goals in comparison to the 37 scored by their opponents. Of those goals, power plays seem to be the difference maker. The ‘Cats have seven power play goals on the season while their opponents have 18. Empty net goals favor the ‘Cats as they have


priest. If it isn’t run by the church, it is, by definition, no good. “He’s a communist and plays jungle music!” says the good Father.

And a high-ranked official also loathes Jimmy for his left-wing politics. His daughter, though, can’t wait to join the club. And Jimmy’s lost love Oonagh (Simone Kirby) is glad to see him back

But local incidents can lead to national repercussions. With Catholic and Protestant labourers striking together in Belfast the Powers That Be feared what James Gralton might inspire. As tensions escalate, who will triumph? Father Sheridan and his supporters? Or Jimmy?

Based on a true story, Jimmy’s Hall is a typical Ken Loach movie. Its politics are decidedly left-wing, but the characters and the ideologies they espouse are never cut-and-dry. For every right-wing Fatherin some ways, I miss the old desktop cases. They made it easy to insert removable media and check to see whether your hard disk light was on. Sure, you can do these things with a tower case. But oftentimes, the tower is tucked away under a desk and isn't so easy to reach.

4: Durable keyboards and mice

Maybe it's just me, but most of the mice and keyboards I come across these days just seem flimsy. Whatever happened to quality? I used to like the old IBM keyboards because they weighed about as much as a brick, and the keys were being enough to actually type on. The keyboards felt solid and unlike today's keyboards, they were hard to wear out.

5: In-person help desk visits

Most of the help


The Future

Tony J. Peterson
-
August 05, 2011

Recruiting more young people is a hot topic among bowhunters, because the future of our sport rests heavily upon the shoulders of a new generation. Carbon Express understands how important this issue is, and they have responded with some youth-friendly offerings. "In the past, we made a variety of arrows like our Predators, which are a great starter arrow. We've expanded that line now so that it includes 600, 700, and even 800 spines. This means that someone shooting a 25-inch arrow at 25 pounds of draw weight can shoot an appropriately spined arrow," said Rezmer before continuing, "We have a lot of youth coming out of the NASP program and they are buying their first bows. The bows feature light draw weightsTrends of methicillin-resistant Staphylococcus aureus (MRSA) and Enterobacteriaceae-producing extended-spectrum beta-lactamase (ESBLE) in eastern France: a three-year multi-centre incidence study.
The objective of this study was to describe trends for the years 2004 to 2006 in the incidence of methicillin-resistant Staphylococcus aureus (MRSA) and Enterobacteriaceae-producing extended-spectrum beta-lactamase (ESBLE) in a large hospital network (70 hospitals in eastern France). The incidence of MRSA per 1,000 patient-days decreased significantly from 0.55 in 2004 to 0.45 in 2006. This trend was observed in medicine and surgery units, whereas MRSA incidence was stable in intensive care, paediatric and obstetric units. The incidence of blood cultures positive for MRSA remained stable at 0.04 per 1,000 patient-days. Conversely, the incidence of ESBLE increased significantly from 0.04 in 2004 to 0.08 in 2006. This increase was caused


where Kate was delivered into the kitchen was real. It was so surreal to walk down to that house that we’ve been filming in for three years and all of a sudden there’s a hospital to connected to it. You felt like you were in a dream. And then Hannah [Zeile] and Mackenzie [Hancsicsak] and Chrissy are all there, they’re never together on set. The whole thing was just very like, “Wait, what show is this?”

BERGER: We went to the rehearsal and we were surprised how moving it was to see them all together, just because it isn’t a combination that we ever get t see together because why would we? And we’re always looking for those combinations we haven’t seen before and looking to find ways towidth of the strike zone, which is the 17 inches of home plate plus the area where the ball grazes either edge of the plate.

The Softball Rules Committee believes the new depictions will aid players in visualizing the strike zone, coaches in teaching the zone to batters, pitchers and catchers, and umpires in consistently calling an accurate strike zone.