a rising economy, the Vietnamese art market is an unexplored territory that worth examining. However, there has been only a limited number of studies examining Vietnamese art and its problems. II. Literature Review 1. The international art market The Vietnamese art market operates on a smaller scale but is still under the influence of the operation of the global art market. The international art market is well-established, but its nature is ambiguous. Horvitz (2009) introduces some essential suggestions to define an art market: (1) profits might not be the primary motivation for the market, there are historical and even psychological values when it comes to a work of art; (2) the information on the art market is limited; and (3) it makes the art market categorize into differentacquaintance of the painter Pham An Hai. The collector sent the paintings to a frame-maker, and the frame-maker found out they were fake. He contacted Pham An Hai immediately. Out of the five paintings, a painting named Du am pho co (The repercussion of the Old Quarter) was still at Pham An Hai's house. Nguyen Ro Hung drew two other arts, but his signature was removed and replaced by Pham An Hai. There is no information on the last two paintings. Pham An Hai later called the collector to tell him the truth, and he also published the story on Facebook so that it could help others avoid the fake. Figure 4: Fake Pham An Hai's Du am pho co (Viet, 2017) Figure 5: Authentic Pham An Hai's


Da case, the news briefly reported the information as because the painting was claimed to be fake, so the auction house had to take action. While in the Thieu nu uong tra by Vu Cao Dam, the real version was shown and presented as evidence, so the auction house was unable to do otherwise. Moreover, the incident of Song Da happened in 1997, when the customs of the Vietnamese art were still new to the international market and auction houses. In the later auctions, occurred from 2008 onwards, only a few Vietnamese artists and art expert showed confusion with the paintings based on their knowledge and familiarity with the painters' style. Thus, the auctioned paintings from 2008 have no hard evidence like Thieu nu uong tra. Therefore, theaccusations would possibly make the painting controversial but could not avert the auction and generate any apparent action. The case of Mo ve mot ngay mai by To Ngoc Van (5) is notable because regardless of its obvious similarities with the painting The Young Beggar by Bartolome Esteban Murillo; there is no response from the auction house; and as of 3 May 2018, the link of the lot on Christie's website is still accessible. From the Vietnamese side, The Vietnam Fine Arts Association did send a document to Vietnam Ministry of Culture, Sports, and Tourism, but so far there has been no response. (Diep, 2017b). In term of direct trading, the most expensive case is a painting of Le Pho (23) purchased in Hong Kong by a Vietnam


still paid US$25,000 for Co gai tho. 15 Figure 12: Left: The French artist's painting. Right: Co gai tho – Nguyen Phan Bach (Lucy, 2017a) Beside the monetary worth, paintings also possess aesthetic, cultural and even philanthropic values but the way that these allegations were settled has diminished such values. The painting An Lac by Nguyen Truong An (1) was a prize-winning artwork and even exhibited by Ho Chi Minh City Museum of Fine Arts. However, only during the exhibition that an audience found out it plagiarized. There was no apparent action from the Ho Chi Minh City Fine Arts Association. The Vice President rationalized the painter's mistake by his young age and his capacity to learn and grow in the future (Thi, Tuan, Thuy, 2017)!? Prior toabout the Vice President of Vietnam University of Fine Arts, who copied his painting multiple times (34). In his opinion, it shows that Vietnamese artists are not serious, and have no selfdiscipline. At the moment, the situation comes to the point of no return, but there are a few individual efforts from experts to raise their voices and strives for the international standard. Nonetheless, the lack of legal and authoritative supports keeps proposing a challenge to keep the Vietnamese art clean. In a similar case of plagiarism from a high-status professor in China, the professor lost his job, reputation and even got banned for life from joining an award (Leng, 2018). Indeed, there is an ongoing philosophical debate on aesthetics and copy, especially in the context of Eastern


outcome of the early success of the economy and the Vietnamese art. The Vietnamese art market will not likely to grow unless the Vietnamese art can develop. Firstly, the Vietnamese art is chaotic: the artists do not hesitate to copy and plagiarize, the auction houses keep selling controversial paintings for the benefit, and the buyer does not know to evaluate the value of art while there is no consultants or experts to help them. Secondly, the attitude towards plagiarism and fake is deeply rooted in the culture of the education, which for a long time, highly encouraging the imitated and replicated thinking than the original and critical thinking. Finally, considering the current status of Vietnam economy, investors are more interest in investments that generate quick income. Therefore, theđúng và đủ sức răn đe ? [Fined the gallery which sold the fake painting of Van Tho: Is it good enough?]. Nhân dân. Retrieved from http://nhandan.com.vn/vanhoa/item/15938102-.html (30 May 2018). An, N. (2016, July 18). Tranh đấu giá ở Hồng Kông có 'phiên bản' tại VN [Auctioned painting in Hong Kong has another "version" in Vietnam]. Thanh niên. Retrieved from https://thanhnien.vn/van-hoa/tranhdau-gia-o-hong-kong-co-phien-ban-tai-vn-724236.html (15 May 2018). Anthony, N. (2016, December 23). Vài nhận xét về bức tranh "Thuyền trên sông Hương" đấu giá trên sàn Christie's ngày 10 tháng 5 năm 2016 [Discussions on the painting "Boats on the Perfume river" auctioned at Christie's on May 10 2016]. NgheThuatXua. Retrieved from http://nghethuatxua.com/vainhan-xet-ve-buc-tranh-thuyen-tren-song-huong-cua-hoa-si-to-ngoc-van/ (25 May 2018). Bach, N. C., & Vuong, Q. H. (2015). Bằng chứng cuộc sống: suy ngẫm về


phát triển bền vững Việt Nam [The evidence of life: thoughts on the sustainable development in Vietnam]. Hanoi: Nha xuat ban Chinh tri Quoc gia – Su that. Bay, V. (2016a, May 15). Buồn trông tranh giả Việt Nam [Witnessing fake Vietnamese painting in sadness]. Thể thao & Văn hóa. Retrieved from https://thethaovanhoa.vn/van-hoa-giai-tri/buon-trongtranh-gia-viet-nam-n20160511151442732.htm (21 May 2018). Bay, V. (2016b, May 04). Làm giả kiệt tác của danh họa Vũ Cao Đàm để bán đấu giá tại Pháp? [Faking Vu Cao Dam's masterpiece to auction in France?]. Thể thao & văn hóa. Retrieved from https://thethaovanhoa.vn/van-hoa-giai-tri/lam-gia-kiet-tac-cua-danh-hoa-vu-cao-dam-de-ban-dau-giatai-phap-n20160504201009284.htm (30 May 2018). Bay, V. (2016c, July 23). Tiếp theo vụ lùm xùm tranh giả tranh nhái: Đã đến lúc để bảo tàng đưa ra kết luận [Following the fake paintings incident: It isto harm you. In short, it is better that we stop unconsciously imitating Caiaphas because the old pharmakos prescription is past its expiration. We no longer need to cling to our collective group identities (race, gender, ethnicity, etc.) to shape laws as a tool of vengeance against those we fear and hate. We can instead crucify the monster inside us.

What made the West great was this simple truth. God desires mercy, not sacrifice. That the individual human being is sacred in body, mind, speech, and, by extension, the fruits of his or her labor. That no ideology or witch hunt can repeal the beauty and dignity of the individual, no matter who they are.

Reject the tyrannical impulses on the Left and the Right.

Peterson's encounters with angry, zealous mobs


down, right in the ocean." "Millions of people was almost killed." "If it hadn't been for that guy Superman, that overgrown Boy Scout." " I want my Liberace record back tonight." " Tonight?" "What are you gonna do with a guy like that?" "He flies around so fast and everything." "I mean, they can't even trace that guy on that radar they got." "Every time they try, he just flies off." " Where?" " North." "Why?" "To ski?" "Otis, every man has his vulnerable point." "Some, like you, Otis, have more than one." "I didn't see Superman's in time." "But now, through patience, invention, and skill my little black box is just about ready." "Oh, that little black box in our cell?" "That little black box, Mr. LuthorHere's my hand, Clark." "Hold it." " Thanks." "You know what?" "They're afraid to let go." " Why?" " They let go, straight to the lawyer." "Oh, I don't know about that." "They look kind of happy to me." "That's because you're blind, Clark." " Oh, yeah." " Here." " No, I've got it." "No, I..." " Yeah." "Clark." "You've gotta look after yourself." "You've only got one pair of eyes." " God." " Lois?" " Now, here." " Right." " Don't say I never did anything for you." " Thank you." "Son!" "Excuse me, please." " Be careful." " What are you doing?" "Get down!" "Get down!" "You embarrass me here in front of everybody." "Lois, did you see what almost happened there?" "That little boy..." "Hey,


about three blocks from you." "No, this is a very special place for me." "I wanted you to see it." "Listen, you warm enough?" "I guess I should be freezing, but I'm not." "Good." "Come on, let me show you." "I don't know." "From the look of them, I'll bet $ 10 they're from Los Ángeles." "Hey, you hippies, get your butts off the road!" "I like the globe." "It flashes red like our Krypton sun." "But not this irritating noise." "Make way." "Did I hear right?" "That son of a bitch give me an order?" "Duane, you take care of it." "Just what in the hell do you think you're doing here?" "What is this symbol?" "Do you follow another leader?" "Follow the leader?" "Holy skunk sweat."line of that fire and nothing happened to him." "I haven't seen the likes of this since Superman." "Yes?" "Yes." "The Newsbeat control room has informed me that a fleet of helicopter gunships is..." " Mr. President, sir, can't we...?" " There's nothing anybody can do." "They have such powers, nothing can stop them." "Where's Superman?" "Where is he?" "Why doesn't he do something?" "Fire again." "Fire again." "Look." "They need machines to fly." " Banking now." " What bravery." "Be nice to them, my dear." "Blow them a kiss." "Rockets ready." "Coming in on target." "Wait, wait." "We're out of control." "We're coming in, coming down." "Can't control it!" "We're coming down." "I win." "I always win." "Is there no one on this planet to even challenge


her every exclusive." "They're the best of friends." "You know what I mean?" "What an undemanding male this Superman must be." "You could use a tuck here and there yourself, sister." "Wait!" " I'm sorry!" " She lives for now." "Kill the rest, starting with him." "Wait." "Wait, wait, wait!" "Wait." "Wait." "Don't you remember the White House?" "The Oval Room?" "We had a few laughs there." "You ought to have that fixed." "General haven't you heard of freedom of the press?" " Superman!" " Superman, thank God." "I mean, get him!" "Come to me, son of Jor-EI!" "Kneel before Zod!" "Watch out." "You all right?" "Son of Jor-EI." "We were beginning to think you were a coward." "I'm not a coward, Zod." "It is extremely likely youInstabullet is unofficial Windows Phone PushBullet client. In comparison with other PushBullet clients it supports all available features supported by this platform. Free version is a trial version for 7 days. After that period you'll need to buy the application to continue using it. Why should you choose Instabullet? - No problems with synchronizations in compare with other PushBullet clients. Devices, Contacts, Subscriptions and Pushes are always up-to-date! - Supports push notifications. - Supports adding, editing, deleting for Devices, Contacts, Subscriptions and Pushes. - Supports searching channels and subscribing to them. - Supports sending Pushes: Notes, Links, Addresses, Lists and all kind of files. - Supports sending to all kind of destination types. - Universal copy and paste feature. - Supports theming - many themes to match user


glitch or something (and I think has happened to me once or twice in the past).

@LetsGoSwitch Yes, Premium is no ads + access to apps on various platforms. You don't even need a free account unless you want to keep track of what you've watched, though. 20 ads was indeed a glitch. You normally only have to sit through 3-5...

Revisions (Netflix) - Mecha anime that sees modern day Shibuya teleported centuries into a post-apocolyptic future where humanity is nearly extinct and they come under attack from monsters known as the revisions. Their only chance of survival rests with the "String Puppets", mecha designed by what remains of humanity in the future, but strangely enough are only able to be piloted by a small group of modern Shibuya's higha dozen other shows easily that I have watched, liked, and gotten frustrated by their lack of conclusion and unconfirmed second season.

Oh and yes, 12-13 episodes isn't inherently bad. I've seen some shows around that length that I really really loved.

@Heavyarms55, yeah, I guess I was just spoiled growing up on Toonami & Adult Swim where they handpicked the popular series to air, so they were likely to be the success stories that were either complete, or at the very least had a number of seasons under their belt.

So in that sense, the reality that most shows are 12-13 episodes long and don't get a sequel is just a bit hard to come to grips with.


MIL-STD-1275 28V military vehicle specification.

Dan continues to study Safe Operating Area of MOSFETs, and has created software tools and conducts training sessions within Linear Technology related to SOA. His SOAtherm model distributed with LTspice allows customers to simulate MOSFET SOA within their Hot Swap circuit simulations using thermal models that incorporate Spirito runaway.

He received an M.S. in Electrical Engineering from Stanford University and B.S. degrees in Electrical Engineering and Computer Engineering from the University of California, Davis.

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Some cookies are required for secure log-ins but others are optional for functional activities. Our data collection is used to improve our products and services. We recommend you accept our cookies to ensure you’re receiving the best performance and functionality our site can provide.viewed with a Zeiss Pascal 5 microscope using a 63x oil immersion lens (Zeiss, Oberkochen, Germany) with the relevant filter settings.

To test the binding properties of the patient plasma filtrate and purified IgG, we used 20-µm frozen sections of brain and lumbar spinal cord of naive rats and, in addition, 20-µm frozen sections from frontal cortex, amygdala, and spinal cord of human control autopsy material without CNS disease. Sections were incubated with patient plasma exchange material in concentrations ranging from 1∶100 to 1∶10.000 and with purified patient IgG in concentrations of 100 µg/ml and 10 µg/ml over night as the primary antibody, followed by rabbit anti-human IgG (Dako) at 1∶200 for 30 minutes and visualized with diaminobenzidine.

Besides binding we were interested in potential cell destruction, complement activation and


and corticoaccumbal glutamate systems (Koob and Volkow, [@B36]; Kalivas and Volkow, [@B33]). All these brain regions are also innervated by histamine-containing nerve fibers originating from the posterior hypothalamic tuberomamillary nucleus both in rodents and in humans (Panula et al., [@B56]; Airaksinen et al., [@B4]; Jin and Panula, [@B31]). Following release, histamine is mainly inactivated by methylation in the brain to an inactive metabolite tele-methylhistamine, whereas in the peripheral organs oxidation by diamino-oxidase is predominant (Haas and Panula, [@B29]). Concentrations of tele-methylhistamine have been shown to correlate well with histamine release in the brain. Very few studies have directly analyzed the role of histamine in alcohol-related behaviors in humans, and animal studies have been carried out only recently. In postmortem analysis, histamine and tele-methylhistamine, the first metabolite of histamine,       Alcohol-preferring AA rats   Mepyramine            No effect on alcohol lever presses               Lintunen et al. ([@B41])
  Self-administration                                Alcohol-preferring P rats    JNJ-39220675          Reduced lever presses for alcohol                Galici et al. ([@B22])
  Conditioned place preference


No, experimental drug                                        Kollonitsch et al. ([@B35]); Garbarg et al. ([@B23])

Inhibitory Role of Histamine in Alcohol-Induced Conditioned Place Preference
============================================================================

Alcohol reward and reinforcement can be also studied using Pavlovian conditioning (Tzschentke, [@B67]). This approach is advisable to use in parallel with the drinking studies in order to exclude intervening variables such as anxiety (Pohorecky, [@B57]) or novelty seeking (Cloninger et al., [@B11]) that might result in altered alcohol drinking. In our laboratory, we are routinely using an unbiased alcohol-induced conditioned place preference (CPP) model in mice originally developed and describedstudies have shown that mice change their preference during the conditioning period without any reinforcing drugs, so in our paradigm place preference is scored as time spent in one of the sides of the chamber during the preference test following the conditioning days (Tzschentke, [@B67]). We compare this time between two groups that received alcohol paired with separate cues. Significant difference between the subgroups indicates place preference.

Studies on histamine's role in morphine dependence are few but support the inhibitory role of histamine in reward and reinforcement. Morphine-induced CPP was attenuated by increasing histamine levels with [l]{.smallcaps}-histidine and potentiated by inhibiting histamine synthesis with α-fluoromethyl histidine in mice (Suzuki et al., [@B64]; Table [2](#T2){ref-type="table"}). H2 receptor antagonist zolantadine potentiated morphine-induced CPP but also induced place preference alone accompanied by


antagonists in psychostimulant addiction-related behaviors, more preclinical studies are needed to really show whether H3R antagonist would be beneficial in other types of drug addictions. One of the key questions to be solved is related to the possible differential expression of H3R in different dopaminergic neurons, and analysis of direct vs. indirect effects of H3R on dopamine release. Whereas it seems that histamine H3 receptor is a key element in alcohol drinking and place preference, the role of histamine in these behaviors is still unclear. The relative importance of histamine and other transmitters regulated by H3 receptor antagonism in several alcohol-related behaviors remains to be studied using specific tools.

Conflict of Interest Statement
==============================

S. Nuutinen, J. Vanhanen, and T. Mäki declare no conflict of interest. P. Panula has received lectureFa void
Start output on the terminal (like typing ^Q at the keyboard).
.It Dv TIOCSCTTY Fa void
Make the terminal the controlling terminal for the process (the process
must not currently have a controlling terminal).
.It Dv TIOCDRAIN Fa void
Wait until all output is drained.
.It Dv TIOCEXCL Fa void
Set exclusive use on the terminal.  No further opens are permitted
except by root.  Of course, this means that programs that are run by
root (or setuid) will not obey the exclusive setting - which limits
the usefulness of this feature.
.It Dv TIOCNXCL Fa void
Clear exclusive use of the terminal.  Further opens are permitted.
.It Dv TIOCFLUSH Fa int *what
If the value of the int pointed to by
.Fa what
contains the
.Dv FREAD
bit as defined in
.Pa Aq sys/file.h ,
then all characters in the input queue are cleared.


1. Introduction
===============

Recently, *ortho*-dihydroxyisoflavones (7,8,4\'-trihydroxyisoflavone, 6,7,4\'-trihdyroxyisoflavone and 7,3\',4\'-trihydroxyisoflavone) are of growing scientific interest to enhance their health-related applications in humans. The isoflavone compounds hydroxylated at a specific *ortho* position have potent antioxidant properties that contribute to their cholesterol-lowering effect, cardiovascular protective, anti-tumor and anti-carcinogenic properties \[[@B1-molecules-18-03028],[@B2-molecules-18-03028],[@B3-molecules-18-03028],[@B4-molecules-18-03028],[@B5-molecules-18-03028],[@B6-molecules-18-03028],[@B7-molecules-18-03028]\]. Furthermore, these compounds are known to display anti-inflammatory and anti-allergenic activity, and acts as potent tyrosinase inhibitors which is associated with inhibition of melanin formation \[[@B6-molecules-18-03028],[@B8-molecules-18-03028]\]. According to many biological effect studies, 7,3\',4\'-trihydroxyisoflavones have received much attention in recent years due to their potentially beneficial estrogenic, antioxidant, and anticancer properties in humans \[[@B1-molecules-18-03028],[@B9-molecules-18-03028]\]. Furthermore, 7,3\',4\'-trihydroxyisoflavone exhibited more effective antioxidant activity using the oxygen radical absorbance capacity (ORAC) assay as well as the oxidation of low-density lipoproteins (LDL) assay \[[@B6-molecules-18-03028],[@B10-molecules-18-03028]\].

In general, monooxygenases act asHis-Tag form of PdR; (**E**) SDS-PAGE 13% gel showing Pdx with His-tag. M, protein marker; lane 1, before induction form of Pdx; lane 2, total form of Pdx; lane 3, soluble form of Pdx; lane 4, His-Tag form of Pdx. Arrow represents protein, respectively.](molecules-18-03028-g002){#molecules-18-03028-f002}

2.4. Characterization of Recombinant CYP105D7 and Kinetic Parameter
-------------------------------------------------------------------

Their activities of the coexpressed proteins were examined by UV-Vis spectroscopy, which revealed the typical characteristics of P450, a heme Soret peak at 420 nm (low spin) in the absence of carbon monoxide. The spectrum of the dithionite-reduced and CO-bound form showed the well known absorption maximum at 450 nm ([Figure 3](#molecules-18-03028-f003){ref-type="fig"}). In [Table 1](#molecules-18-03028-t001){ref-type="table"}, we showed the apparent specificity constants (kcat/Km) by fitting the concentration-dependent data to the linear region of the Michaelis-Menten Lineweaver-Burke curve. The kcat/Km


1 min at 94 °C, annealing for 1 min at 68 °C, and extension for 1 min 30 s at 72 °C. The PCR product was cloned into NdeI/BamHI sites of expression vector pET24ma. For His-tag plasmid of P450, it was N-terminally attached (Novagen). Also, it was attached *N*-terminally at expression vector pET28a+ for cyp28.

3.4. Coexpression of CYP105D7 and Redox Partner for *in Vivo* System
--------------------------------------------------------------------

The plasmids of P450 and redox partner were transformed together into *E.coli* BL21(*DE3*). The transformant was grown in Luria-Bertani (LB) medium containing 100 μg·mL^−1^ of kanamycin and ampicillin at 37 °C until the cell concentration reached to an OD~600nm~ of 0.6, and isopropyl-thio-β-D-galactopyranoside (IPTG) and δ-aminolevlunic acid as heme precursor were added to a final concentration of 0.5 mM, followed by growing for overnightthe heme active site of the P450 in a carefully orchestrated process which ultimately leads to the observed hydroxylation activity. Redox equivalents are transferred from NADH via the proteins PdR and Pdx to enzyme CYP105D7 converting the daidzein hydroxylation. The CYP105D7 added hydroxyl group to B ring of daidzein to form 7,3,\'4,-trihydroxyisoflavone in *E. coli* system with a redox partner.

Through an *in vitro* reaction, we studied an isoflavone hydroxylase activity of CYP105D7 using an artificial electron transport system, consisting of ferredoxin reductase and ferredoxin. The chemical structure of the product was elucidated using GC-MS to confirm the location of the new hydroxyl group. We demonstrated the enzyme-tailored hydroxylation of daidzein, as a proposed method for structural modification of this substrate for further functional applications as a phytoestrogen compound.

This


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Attn all Investors/Builders. Property with huge lot with great potential. Potential to build up to 20-24 town homes or condominiums(buyer to verify all information with the city) Currently property is legally a 5 unit property with 1 additional unit being rented out (a 1 bedroom). Deal makes sense for what you canrelations—and rule through relationships—more attractive to the unipolar state. But there are also crosscutting incentives that favor multilateral arrangements. I will return to them later in the chapter.

##### _Provision of Public Goods_

A second impact of unipolarity is on the provision of public goods. During the era of Cold War bipolarity, the United States found itself as a provider of public goods in the areas of security provision, maintenance of economic openness and stability, and support for the rules and institutions that formed the order. This willingness of the leading state to act in behalf of the system as a whole—to provide system services to participants within the order—is a key characteristic of liberal hegemony. The question is whether and in what ways the shift to unipolarity alters the


a half century of extraordinary American economic growth. In 1870, the United States had 8.8 percent of global GNP. In 1913, it had 18.9 percent, and in 1944, its share had grown to 35 percent. See Angus Maddison, _The World Economy: Historical Statistics_ (Paris: OECD, 2003), 258. Moreover, the war had left the United States with a extensive worldwide system of bases, airfields, and communication stations. In 1945, Assistant Secretary of the Navy Strue Hensel estimated that the United States had built 443 bases and other facilities during the war, including 195 in the Pacific, 228 in the Atlantic area, and 11 in the Indian Ocean and Middle East. Robert E. Harkavy, _Great Power Competition for Overseas Bases_ (Oxford: Pergamon, 1982).

3 Kennedy, _Rise and Fall of the Greathad in fact created a deeply rooted, dynamic, and historically unique political order in the shadow of the Cold War. This inside order expanded and deepened during the 1990s and into the new century. Its watchwords were globalization, integration, democratization, and the expansion of liberal international order. NAFTA, APEC, and the WTO were elements of this expansion and deepening process. The expansion of NATO and the reaffirmation of America's alliances in East Asia also amounted to a consolidation of the American-led postwar liberal international order. Adding stability to this globalizing system were nuclear weapons, which made great-power war—and its transforming impact—unlikely, and the democratic character of the leading industrial societies, which gave the system a core of liberal democratic states operating within a democratic zone of peace.

Second, deeper


NATO bombing of Serbia in 1999 provided a revealing glimpse of the new patterns of world politics in the post-Cold War era: despotic states and hostile regimes in peripheral regions generate threats that challenge the old rules and institutions of the postwar Western order and provoke the controversial use of American military force. Secretary of State Madeleine Albright described America as the "indispensable nation"—the only global power that could provide enlightened and forceful leadership across regions and realms of world politics.35 But others around the world worried, such as French Foreign Minister Hubert Verdrine, who described the United States as a "hyperpower." When asked in an interview with _L'Express_ about what could be done to resist the overbearing power of the United States, Verdrine said: "Through steady andchoices that face liberal-order builders today. This is the tension between the dominance of a powerful state in running the liberal order and shared norms of democratic community. On the one hand, the United States has used its preponderant power to organize and manage the system. Liberal international order did not spontaneously emerge. It had to be created and ruled. Taking on this role has given the United States a privileged position within the order. On the other hand, the liberal order was also built with a core group of Western democracies that shared norms and expectations of respect, reciprocity, and consensual rule. The order that emerged was both hierarchical and liberal in character. But conflicts have persisted in the awkward reconciliation—or at least management—of these tensions between


Westphalian sovereignty will continue. Nonetheless, finding consensus on the norms of intervention in a post-Westphalian world is deeply problematic—yet short of establishing such legitimate authority, the international order will continue to be troubled and contested.24

A third issue relates to liberal democracy and the international rule of law. Here the question is, how do you build up authority and capacity at the international level—in international bodies and agreements—without jeopardizing popular rule and accountability built into liberal democratic states? Can the authority and capacity of the international community to act be strengthened without sacrificing constitutional democracy at home? As we noted above, this is an unresolved problem in the liberal international project. Liberals anticipate a growing role for the international community in the functioning of the global system. The postwarsingle helix by neutralization with HCl. Finally, the single helical conformation can be renatured to the original triple helix by heating or dialysis \[[@B11-molecules-20-09745]\]. When renatured, some β-(1→3)-glucans, such as scleroglucan, are able to adopt unusual conformations, for instance circular triple helices structures \[[@B12-molecules-20-09745]\]. The possible mechanism is that closed triple helices are converted into single strand by partially opening one end of the triple helix with sodium hydroxide. Subsequent neutralization returns it to the original closed triple helix. The partially opened structure can be maintained for up to 20 days \[[@B7-molecules-20-09745],[@B13-molecules-20-09745]\]. The significant differences between the triple- and single-helix or partially opened conformations include the accessibility to OH-2 functions of the main-chain strand for further chemical modification \[[@B14-molecules-20-09745]\].

The degree of polymerization (DP) of β-(1→3)-glucans is a determinant


X-ray crystallographic data of the N-βGRP of both *Plodia interpunctella* and *Bombyx mori* in complex with laminarihexaose ([Figure 1](#molecules-20-09745-f001){ref-type="fig"}). Such N-βGRP is able to activate the proPO cascade leading to the encapsulation of the invading micro-organism \[[@B83-molecules-20-09745],[@B92-molecules-20-09745]\]. In the reported data, these authors confirmed the localization of the interaction site on the convex β-sheet of the globular protein like for *Drosophila* and the stabilization of the resulting complex thanks to a long loop between the β3 and β4 strand. These results are in contradiction with previous data on N-βGRP of *B. mori* that localize the site of recognition on the concave *C*-terminal face of the protein by NMR titration in the presence of laminarin \[[@B87-molecules-20-09745]\]. Such discrepancies might be associated with the use of different sources of laminarin.authors confirmed the stacking of the non-reducing end with hydrophobic residues on one sub-site. The other sub-site was also identified with glutamine as essential residue that contributes mainly through H-bond interaction. Interestingly, this CBM is associated with a cellulase and not a laminarase. Fungi are the main competitors of the *C. mixtus* bacteria for digestion of biomass. *Bh*CBM6 associated with the cellulase might be used to rapidly recruit the glucanase at a site of fungal invasion and thus profit of the lesion to digest easily accessible mixed-glucans or callose. Multiple bindings were also described for family 13 CBM from *Cellulosimicrobium cellulans* where three asparagines and one tryptophan were identified as crucial residues for the interaction \[[@B119-molecules-20-09745]\]. The authors reported cooperative multivalent bindings of laminarin to three different repeat


public money deployed, she said.

Germany would also create positions for 100 new professors in AI.

The government’s plans ran into immediate criticism from the opposition Greens.

“More than a year after the federal election, a lot remains more than fuzzy,” said Tabea Roessner, party spokeswoman for network policy and consumer protection.

“The experience of the black-red (ruling) coalition in recent years, especially as concerns broadband expansion, has taught us the bitter lesson that implementation strategies and rhetoric often don’t lead to tangible results.”

Hampered by an outdated research infrastructure and restrictive data protection laws, Germany has yet to produce a world-beating start-up that pioneers the use of AI, although 120 companies have formed a lobby group to further the process.

A 2017 Organisation for Economic Cooperation and Development study ranked Germany 29th outuse crate::error::Error;
use serde_json;
use crate::response::Serializer;
use crate::util::BufStream;

use futures::{future, Future, IntoFuture};
use http;

use std::sync::Arc;

/// Handles an error generated by a resource method.
///
/// In the event that an error occurs while processing an HTTP request,
/// implementations of `Catch` have the opportunity of gracefully handling the
/// error. This usually means responding with a friendly error response.
///
/// For example, if the error is generated due to no routes matching the HTTP
/// request, then a 404 response should be returned. If a route was matched, but
/// the arguments were not satisfied, then a 400 response should be returned.
pub trait Catch: Clone {

    /// The HTTP response body type
    type Body: BufStream;

    /// Future yielding the HTTP response.
    type Future: Future<Item = http::Response<Self::Body>, Error =


The microsponge delivery system of benzoyl peroxide: preparation, characterization and release studies.
Benzoyl peroxide (BPO) is commonly used in topical formulations for the treatment of acne and athletes foot. Skin irritation is a common side effect, and it has been shown that controlled release of BPO from a delivery system to the skin could reduce the side effect while reducing percutaneous absorption. Therefore, the aim of the present study was to produce ethylcellulose microparticles containing BPO which were able to control the release of BPO to the skin. In order to optimize the microparticle formulation, factors affecting the physical properties of microparticles were also investigated. Benzoyl peroxide microparticles were prepared using an emulsion solvent diffusion method by adding an organic internal phase containing benzoyl peroxide, ethyl cellulose and dichloromethaneinto a stirred aqueous phase containing polyvinyl alcohol. Drug content, particle size analysis and loading yield were determined in the prepared microparticles. BPO microparticles were then incorporated into standard vehicles for release studies. Scanning electron microscopy was used to study the shape and morphology of the microsponges. The micrograph of microsponges showed that they were spherical in shape and contained pores. These pores resulted from the diffusion of solvent from the surface of the microparticles and thus the particles were designated as microsponges. It was shown that the drug:polymer ratio, stirring rate, volume of dispersed phase influenced the particle size and drug release behavior of the formed microsponges and that the presence of emulsifier was essential for microsponge formation. The results showed that, generally, an increase in the


folder, which doesn't work using this code.

A:

"I also want standard behavior allowing me to drop a file into a closed folder, which doesn't work using this code."
Why not set the on drop event for each folder, removing the item (folder or file) from it's previous list, then adding it to the list hidden inside the closed folder?  From what I can guess, the lists you can move it to at the moment are the ones that aren't 'display: none'. So the work around would be to have a drop event for folder items.

the study, four dropped out after randomization and before initiation of the intervention ([Figure S1](#jdi12920-sup-0001){ref-type="supplementary-material"}); 87.8% of the participants in the alogliptin group and 89.7% in the metformin group achieved 100% compliance. The average final dose in the metformin group was 1075.8 ± 430.4 mg by the physician\'s discretion.

Primary clinical outcomes {#jdi12920-sec-0014}
-------------------------

Compared with the baseline values, alogliptin significantly increased bodyweight (66.5 ± 19.2 to 67.6 ± 19.3 kg, *P* = 0.001), BMI (25.4 ± 6.1 to 25.8 ± 6.3 kg/m^2^, *P* = 0.002) and fat mass (20.3 ± 12.8 to 21.8 ± 14.5 kg, *P* = 0.003), whereas metformin had no significant effect on body composition. Alogliptin was inferior to metformin in reducing bodyweight (0.84 ± 1.57 vs −0.35 ± 1.53 kg, *P* = 0.002), BMI (0.34 ± 0.69 to −0.15 ± 0.56 kg/m^2^, *P* = 0.002) and fat mass (1.49 ± 5.06 vs −0.04 ± 1.81 kg, *P* = 0.042; Table [1](#jdi12920-tbl-0001){ref-type="table"}).

######

Treatment effects of metformin or alogliptin on body composition and metabolic parameters


& Sons, Ltd

### Adverse events {#jdi12920-sec-0019}

The most common adverse events were gastrointestinal symptoms, such as diarrhea, loose stools, flatulence, abdomen distension, stomach heaviness, nausea and appetite loss, which occurred primarily in the metformin group ([Table S5](#jdi12920-sup-0001){ref-type="supplementary-material"}). Metformin doses were reduced to minimum of 500 mg among five patients because of gastrointestinal symptoms under the physician\'s discretion. Two participants in each treatment group experienced mild hypoglycemic symptoms. In the alogliptin group, one participant was treated with insulin, and another patient was treated with diet only. In the metformin group, two participants were treated with insulin. One patient in the metformin group wanted to withdraw consent and discontinue metformin because of severe gastrointestinal symptoms, such as severe nausea and vomiting. Metformin was discontinued and replaced with intensive insulin therapy by the investigatorfor two patients with serious adverse effects (esophageal cancer and pneumonitis).

Discussion {#jdi12920-sec-0020}
==========

We carried out the present open‐label randomized, parallel trial comparing the DPP‐IV inhibitor, alogliptin, and metformin as add‐on to current hypoglycemic agents in Japanese participants with type 2 diabetes. Our study was the first to investigate the pleiotropic effects of these drugs, and identify clinical factors associated with reduced bodyweight and glucose levels after add‐on therapy.

In the present study, alogliptin significantly increased bodyweight, BMI and fat mass, whereas metformin had no effect on body composition. In addition, BMI at baseline was associated with changes in bodyweight negatively in the metformin group and positively in the alogliptin group. These findings suggest that metformin and alogliptin exert opposite effects on bodyweight in diabetes patients who were overweight. In mice, alogliptin


of quality of life, the Diabetes Treatment Satisfaction Questionnaire scores for convenience (item 4), understanding of your diabetes (item 6), recommend to others (item 7) and wish to continue treatment (item 8) increased significantly from baseline in the alogliptin group. Adverse gastrointestinal symptoms accounted for as high as 14 out of 19 adverse events in the metformin group, which might be attributable to the poor satisfaction with metformin. It could be possible that 1,000 mg (500‐mg tablets, twice daily) of metformin is too high as a starting dose for relatively lean Japanese people with type 2 diabetes. Because the efficacy of alogliptin is similar to that of metformin and the drug is not limited by gastrointestinal tolerability or contraindications, alogliptin might be a credible alternative for participants with type 2 diabetes who, for some reason, if the Relation
     * Service is not registered in the MBean Server
     * @exception NoSuchMethodException  If the MBean does not implement the
     * Relation interface
     * @exception InvalidRelationIdException  if:
     * <P>- no relation identifier in MBean
     * <P>- the relation identifier is already used in the Relation Service
     * @exception InstanceNotFoundException  if the MBean for given ObjectName
     * has not been registered
     * @exception InvalidRelationServiceException  if:
     * <P>- no Relation Service name in MBean
     * <P>- the Relation Service


           Role newRole,
                              List<ObjectName> oldRoleValue)
        throws IllegalArgumentException,
               RelationServiceNotRegisteredException,
               RelationNotFoundException;

    /**
     * Removes given relation from the Relation Service.
     * <P>A RelationNotification notification is sent, its type being:
     * <P>- RelationNotification.RELATION_BASIC_REMOVAL if the relation was
     *  RelationTypeNotFoundException;

    /**
     * Retrieves role value for given role name in given relation.
     *
     * @param relationId  relation id
     * @param roleName  name of role
     *
     * @return the ArrayList of ObjectName objects being the role value
     *
     * @exception RelationServiceNotRegisteredException  if the Relation
     * Service is not registered
     * @exception IllegalArgumentException  if null parameter
     * @exception RelationNotFoundException  if no relation with given id
     * @exception RoleNotFoundException  if:


 if null parameter
     * @exception RelationNotFoundException  if no relation with given id
     *
     * @see #getRoles
     */
    public RoleResult setRoles(String relationId,
                               RoleList roleList)
        throws RelationServiceNotRegisteredException,
               IllegalArgumentException,
               RelationNotFoundException;

    /**
     * Retrieves MBeans referenced in the variousA stochastic model to simulate the growth of anchorage dependent cells on flat surfaces.
A stochastic model is proposed to simulate the growth of anchorage dependent cells on a flat surface. The model, based on representing the cell shapes on the surface as external irregular polygons with the nuclei distributed as a set of Poisson points (producing a modified Voronoi tessellation of 2 space) and incorporating a distribution function to describe cell division of the perimeter cells of the colony, provides data not only on population dynamics but also on the patterns produced by clusters of cells in the colony. These patterns produced by the model are qualitatively similar to observations reported for some cell cultures. The periods of induction, rapid growth, and decreasing growth asymptoting to zero as


that the sensing resistor, in series with its respective output drive transistor, adversely affects the output signal integrity. To minimize such effects, the voltage drop across the resistor must be limited to a small amount, for example, 100 millivolts. To achieve this minimal voltage drop, the sensing resistor must have a relatively low resistance, such as approximately 1 ohm, or less. Manufacturing such resistors with acceptable accuracy and reliability, however, in present semiconductor processing technologies, such as CMOS, is both difficult and costly. Without reliably precise resistor values, there is a general risk of increased power dissipation associated with the voltage drop across the sensing resistor as well as a disruption in circuit operation due to degraded signal integrity. Signal degradation occurs, for example, when the magnitude ofQ:

In a triangle,what is the ratio of the distance between a vertex and the orthocenter ...

In a triangle,what is the ratio of the distance between a vertex and the orthocenter and the distance of the circumcenter from the side opposite vertex.

A:

The triangle is $\Delta ABC$. Let's say that $O$ is the circumcenter, $H$ the orthocenter and $G$ is the centroid. We are going to use a very usefull result that comes from the Euler Line.
The Euler Line says that $OH=3GO \quad (1)$.
If we use vectors to solve that problem the relation $(1)$ says that if we place the origin at $O$ then the coordinates of the orthocenter will be given by $H=A+B+C$ and then:
$$\vec{AH}=H-A=B+C$$
We also know that the distance from the circuncenter ($O$) to the side


have demonstrated that the above phenomenon operates with various low- to mid-level features and objects as visual stimuli. Memory of features of an object (e.g. colour) was reported to be influenced by spatial context^[@CR13]^, while remembered size of individual circles was biased by the mean of other circles^[@CR14]^. Likewise, spatial frequencies of gabor-patches were biased by the previously presented patches^[@CR15]^. Influence on visual short-term memory of shape, orientation, and colour of objects was found by manipulating the respective features of the non-target object sets in a change detection task^[@CR16]^. More recently, this phenomenon was also reported with high-level visual stimuli, such as faces which were perceived as more attractive in groups than in isolation^[@CR11],[@CR17],[@CR18]^.

All the above-mentioned studies found the effect of contextual ensemble statistics on the perception oflater timescale in the intervening blank of 1,000 between the stimulus offset and judgment onset (Fig. [1A](#Fig1){ref-type="fig"}). To ascertain if the perceptual effects in *Experiments 1 and 2* were actually a result of visual processing of the stimulus within 200 ms, we modified the event timeline of the task by including a high-contrast backward visual mask for 1,000 ms immediately following the stimulus offset (Supplementary Information Fig. [1](#MOESM1){ref-type="media"}) to suppress processing of the stimulus in the visual system. The data collected were tested by permutation-based one-sample t-tests (all possible permutations) for difference of the mean of indices from the reference value of zero. This task manipulation in TD revealed that peripheral ensemble emotion information (covert ensembles) had no perceptual effect on centre emotion perception (mean ± sem of indices = 0.025 ± 0.09; *t*~(10)~ = 0.28; *p* = 0.79; Supplementary Information Fig. [2B](#MOESM1){ref-type="media"}),


measures (of the context stimuli) has on the perception of local features of stimuli by parametrically varying the ensemble information while encoding. It is worth noting here that this effect was quantitatively evident when the contextual stimuli were behaviourally irrelevant (had no task relevance; participants were told to ignore them) and the stimuli (both context and target) were co-presented for a brief period (200 ms). Thus, despite the task demand of perceiving only the intensity of the centre face, the participants' visual systems subconsciously accounted for the summary values provided by the peripheral stimuli. The influence of manipulating the global summary measures of the peripheral faces on centre face perception was mutually in opposite directions for the emotion and brightness task sessions in both groups. This indicates that potentiallyis noteworthy however, that as revealed by our Experiment 3, the peripheral ensembles presented for 200 ms (encoding duration) actually take \>200 ms for visual processing and thereby for the perceptual modulation to gain effect at least with high-level emotion information.

A recent study has demonstrated that, in human participants, contextual stimuli have a marked influence on the detection of changes in facial expressions^[@CR41]^. Using affective priming and a bi-directional response task, the authors reported that when participants were exposed to an intervening context (presented for 1,000 ms), they returned a greater proportion of correct judgments of the direction of change between pre- and post-context facial expressions. This applied to trials where valence was consistent with the actual direction of change in the facial expressions (either positive or negative). Although some aspects


scales of 200--1000 ms, which may have later led to the perceptual bias in our results. Consequently, we speculate that a similar but still distinct mechanism might be involved in our study, and feel that our results supplement the previous study's findings^[@CR41]^.

It has also been reported that perceptual judgments of facial emotional intensity in humans is susceptible to implicit racial biases^[@CR43]^. Further, a recent study has demonstrated that the facial features that one learns over time influences how faces are evaluated socially^[@CR44]^. Since our entire participant pool comprised of Japanese adults, who were likely to have been relatively unfamiliar with Caucasian faces, whether our experimental results, which were obtained using stimuli comprising Caucasian faces^[@CR45]^, would differ if Asian or specifically Japanese facial stimuli were used merits future exploration.

In *Experimenttrial, the participants were instructed to fixate on a white cross in the centre of the screen (0.5° × 0.5°), which was presented for a randomly determined duration of between 1,500 and 2,000 ms (Fig. [1A](#Fig1){ref-type="fig"}). The offset of the cross was followed without delay by the presentation of a set of five face images; all images were presented with the edges of the image subtending \~4 × 4°. The image set was positioned such that the central face image was directly at the centre of the screen. The four flanking face images were positioned in four perpendicular directions (right and left; top and bottom) from the centre image. The respective centres of the four flanking images were 5° from the mid-point of the centre image with a gap of 1° among the edges


c(NA, -6L), class = "data.frame")

Base2<-structure(list(Month = c("m11", "m12", "m13", "m14", "m15", "m16",
"m11", "m12", "m13", "m14", "m15", "m16"), variable = structure(c(1L,
1L, 1L, 1L, 1L, 1L, 2L, 2L, 2L, 2L, 2L, 2L), .Label = c("Index1",
"Index2"), class = "factor"), value = c(0.044370892419913, 0.0437161234641523,
0.0516857394621815, 0.0495793011485982, 0.0506456741259283, 0.0314653057147897,
0.0299405579124744, 0.0296145768664101, 0.0269727649059507, 0.0250663815369419,
0.0233469715385275, 0.0201801611981898)), .Names = c("Month",
"variable", "value"), row.names = c(NA, -12L), class = "data.frame")

Many thanks for your help!

A:

First steps towards a solution:
g1.1 <- g1 + theme_bw() + theme(legend.position="top")
g2.1 <- g2 + theme_bw() + theme(panel.grid=element_blank()) +
    theme(panel.background = element_rect(fill = NA))
plot(double_axis_graph(g1.1,g2.1))

Now we need to fix:

Weird grey background everywhere - edit: fixed it!
The legend

And survive Hadley's wrath for doing what is fundamentally flawed.

A:

I used some guys code to build my own here
grid.newpage()

# two plots
p1 <-am not sure it is for real. Further down the thread we come right back to Archer. My most fun answer was the one that went 'Ew. Ew. Ew.'

Here is a podcast of an interview with Maxon Crumb which references the documentary during which Maxon claims to swallow purification cloth which cleanses the intestines. Shatkarma: Yoga Cleansing Techniques include swallowing a 3" by 20' piece of water-soaked muslin, allowing it to stay in the stomach for 5 minutes, and then pulling it out very slowly (so, no, it is not pulled out the other end, and no, it is not made of kelp). This technique is combined with a second enema-like technique (see link) which cleanses the rest of the digestive tract.

A kelp tape is improbable on many


889101, 890341, 891579, 892815, 894049, 895281?
-x**2 + 1243*x + 887859
What is the z'th term of -8705, -17395, -25971, -34331, -42373?
17*z**3 - 45*z**2 - 8674*z - 3
What is the p'th term of -37957, -75959, -113959, -151957, -189953?
p**2 - 38005*p + 47
What is the u'th term of 1173406, 2346773, 3520140?
1173367*u + 39
What is the c'th term of 4100, 4295, 4460, 4595?
-15*c**2 + 240*c + 3875
What is the n'th term of 21680550, 43361094, 65041638, 86722182, 108402726, 130083270?
21680544*n + 6
What is the o'th term of -992981, -992996, -993001, -992990, -992957, -992896, -992801, -992666?
o**3 - o**2 - 19*o - 992962
What is the y'th term of 493, 1078, 1835, 2836, 4153?
12*y**3 + 14*y**2 + 459*y + 8
What is the n'th term of 8682, 16575, 23672, 29973?
-398*n**2 + 9087*n - 7
What is the t'th termdetectable. α1(I) Collagen DNA in sera was quantitative using our method. The levels of serum α1(I) collagen DNA were significantly increased in scleroderma patients compared with healthy control subjects or systemic lupus erythematosus patients. According to the receiver-operator curve analysis, serum α1(I) collagen DNA levels were shown to be effective as a diagnostic marker of scleroderma. Furthermore, when we determined the association of serum α1(I) collagen DNA levels with clinical/laboratory features in scleroderma patients, those with elevated α1(I) collagen DNA levels showed significantly higher prevalence of pitting scars/ulcers. In summary, elevation of serum α1(I) collagen DNA levels in scleroderma patients may be useful as the diagnostic marker, reflecting the presence of vasculopathy.


Q:

How to pipe Perforce command to "Find" CMD command?

In Perforce CLI, the output of this command: p4 login -s is Perforce password (P4PASSWD) invalid or unset. if no user is logged in (see screenshot below).
When I pipe this command to Find command, I expect to get a blank line, but I still get the same line:

How can I pipe this command as I expect?

A:

The Perforce password (P4PASSWD) invalid or unset. message is output to STDERR, and find (and findstr, for that matter) only operate on STDOUT.  To solve this, use this:
p4 login -s 2>&1 | find "gg"

This will tie the output of STDERR (that is, stream 2) to STDOUT (stream 1).

designed to allow researchers to obtain usage data without access to the personal health information, protecting participants' health information privacy.

Adverse events and data monitoring {#Sec12}
----------------------------------

In the follow-up questionnaires at months 6 and 9, participants will be asked to note any serious adverse events, including falls and cardiovascular/musculoskeletal events \[[@CR32]\]. Adverse events will be reviewed by the Data and Safety Monitoring Committee, which will recommend terminating the study, if warranted. Additionally, at any time during the study period, participants will report any serious adverse events directly to the study coordinator. In the event of a severe adverse event due to participation in the study, participants will be recommended to follow-up with their family doctor as well as have the option to meet with a rheumatologist (DL) or a PT


outcomes measured at weeks 26 and 52 in the II and DI groups. We will employ generalized linear mixed-effect models (GLMMs), adjusting for baseline value on the outcome variable and sex as covariates. These models are the most efficient and recommended statistical methods for analyzing longitudinal clinical trial data with missing data \[[@CR34], [@CR35]\] and can account for data missing at random without the need to perform explicit imputations of the missing values \[[@CR36]\]. Binary indicators of group and months since baseline will allow us to test their interaction (*P* \<0.05 for two-tailed Wald test), which addresses whether the outcome post-intervention is significantly better in the II group than in the DI group. Data transformation, if needed, will be applied to continuous outcomes to satisfy the assumption of normality.authors declare that they have no competing interests. DL is supported by the Mary Pack/Arthritis Society Chair in Rheumatology award. TL-A is supported by the Canada Research Chair Program. HX is supported by the Maureen and Milan Ilich/Merck Chair in Statistics for Arthritis and Musculoskeletal Diseases award. LCL is supported by the Harold Robinson/Arthritis Society Chair in Arthritic Diseases award, the Canada Research Chair Program, and the Michael Smith Foundation for Health Research (MSFHR) Scholar Award.


Failure to maintain stem cells with age is associated with conditions such as tissue degeneration and increased susceptibility to tissue damage in many organisms, including humans. This proposal addresses how aging affects stem cells using the C. elegans germ line as a model. Studies using C. elegans and its germ line have revealed conserved mechanisms of aging and stem cell biology, therefore this proposal combines a well-established genetic model for aging studies and a well- defined, accessible stem cell system, providing a unique opportunity to dissect the effects of aging on stem cell dynamics. We will determine the cellular mechanisms underlying stem cell depletion and its prevention by the insulin/IGF-signaling pathway. We will also determine the specific tissue requirements for this particular anti-aging effect of the insulin/IGF-signaling pathway.said that Loitam’s roommates on seeing him bleeding had asked for the cause and he reportedly told them that he had a quarrel with senior students.

The signs on his body, bear clear and distinctive signs of assault. However, many conflicting reasons have been assigned as the cause of his death even before the details of the post mortem are made available, which raising concern of cover up of the casesaid Ringo Pebam of ‘Justice for Loitam Richard Group’.

Richard’s parents are convinced that their son died of campus violence as there are indications and witness accounts of Richard having an altercation with other students on the evening of April 17, the night before his death.

The studnet unions stated protest in Bangalore on Sunday demanding justice. They alleged the local


long before a Halo game that didn't stick to the series' traditional first-person view would be released. Although it was never ďofficiallyĒ released, Halo Zero

Feedback

If you enjoyed this Mega Man Soccer review, you're encouraged to discuss it with the author and with other members of the site's community. If you don't already have an HonestGamers account, you can sign up for one in a snap. Thank you for reading!

You must be signed into an HonestGamers user account to leave feedback on this review.= restTemplate.exchange(
				createURLWithPort("/surveys/Survey1/questions/Question1"),
				HttpMethod.GET, entity, String.class);

		String expected = "{id:Question1,description:Largest Country in the World,correctAnswer:Russia}";

		JSONAssert.assertEquals(expected, response.getBody(), false);
	}

	@Test
	public void retrieveAllSurveyQuestions() throws Exception {

		ResponseEntity<List<Question>> response = restTemplate.exchange(
				createURLWithPort("/surveys/Survey1/questions"),
				HttpMethod.GET, new HttpEntity<String>("DUMMY_DOESNT_MATTER",
						headers),
				new ParameterizedTypeReference<List<Question>>() {
				});

		Question sampleQuestion = new Question("Question1",
				"Largest Country in the World", "Russia", Arrays.asList(
						"India", "Russia", "United States", "China"));

		assertTrue(response.getBody().contains(sampleQuestion));
	}

	@Test
	public void addQuestion() {

		Question question = new Question("DOESNTMATTER", "Question1", "Russia",
				Arrays.asList("India", "Russia", "United States", "China"));

		HttpEntity entity = new HttpEntity<Question>(question, headers);

		ResponseEntity<String> response = restTemplate.exchange(
				createURLWithPort("/surveys/Survey1/questions"),
				HttpMethod.POST, entity, String.class);

		String actual = response.getHeaders().get(HttpHeaders.LOCATION).get(0);

		assertTrue(actual.contains("/surveys/Survey1/questions/"));

	}

	private String createURLWithPort(final String uri) {
		return "http://localhost:" + port + uri;
	}

	private String createHttpAuthenticationHeaderValue(String userId,
			String password) {

		String auth = userId + ":" + password;

		byte[] encodedAuth = Base64.encode(auth.getBytes(Charset
				.forName("US-ASCII")));

		String headerValue = "Basic " + new String(encodedAuth);

		return headerValue;
	}

}
```
### src/test/java/com/in28minutes/springboot/controller/SurveyControllerTest.java
```
package com.in28minutes.springboot.controller;

import static org.junit.Assert.assertEquals;

import java.util.Arrays;

import org.junit.Test;
import org.junit.runner.RunWith;
import org.mockito.Mockito;
import org.skyscreamer.jsonassert.JSONAssert;
import org.springframework.beans.factory.annotation.Autowired;
import org.springframework.boot.test.autoconfigure.web.servlet.WebMvcTest;
import org.springframework.boot.test.mock.mockito.MockBean;
import org.springframework.http.HttpHeaders;
import org.springframework.http.HttpStatus;
import org.springframework.http.MediaType;
import org.springframework.mock.web.MockHttpServletResponse;
import org.springframework.test.context.junit4.SpringRunner;
import org.springframework.test.web.servlet.MockMvc;
import org.springframework.test.web.servlet.MvcResult;
import org.springframework.test.web.servlet.RequestBuilder;
import org.springframework.test.web.servlet.request.MockMvcRequestBuilders;

import com.in28minutes.springboot.model.Question;
import com.in28minutes.springboot.service.SurveyService;

@RunWith(SpringRunner.class)
@WebMvcTest(value = SurveyController.class, secure = false)
public class SurveyControllerTest


    -      No Data             No more entries, awaiting next Value
    return node;
}

// This example is included to illustrate non-periodic data. For the purposes of Historian 2
// examples consider a source historian with the following data:
// Timestamp Value  StatusCode         Notes
// 12:00:00  -      Bad_NoData         First archive entry, Point created
// 12:00:02  10     Raw, Good
// 12:00:25  20     Raw, Good
// 12:00:28  25     Raw, Good
// 12:00:39  30     Raw,Good StatusCode value
// 12:00:52 FALSE Raw, Good
// 12:01:12 FALSE Raw, Good
// 12:01:17 TRUE Raw, Uncertain Value is flagged as questionable
// 12:01:23 TRUE Raw, Good
// 12:01:26 FALSE Raw, Good
// 12:01:30 TRUE Raw, Good
// - No Data No more entries, awaiting next Value
// For the purposes of all Historian 4 examples:
//     1) TreatUncertainAsBad = True. Therefore Uncertain values are treated as Bad, and not
// included in the Aggregate call.
// 2) Stepped Attribute = True. Therefore SteppedInterpolation is used between data points.
// 3) UseSlopedExtrapolation = False. Therefore SteppedExtrapolation is used at end
// boundary conditions.
// 4) PercentGood = 100, PercentBad = 100.
// For Boolean data interpolation and extrapolation shall always be stepped.
export function createHistorian4(addressSpace: any) {
    const node = addressSpace.getOwnNamespace().addVariable({


Three Cabinet secretaries have appeared to distance themselves from President Trump in the wake of his response to the violence in Charlottesville. (Bastien Inzaurralde/The Washington Post)

Three Cabinet secretaries have appeared to distance themselves from President Trump in the wake of his response to the violence in Charlottesville. (Bastien Inzaurralde/The Washington Post)

President Trump’s senior aides are increasingly airing their private disagreements publicly, exposing a widening rift between the president and key members of his administration over his handling of racial divisions exposed by white supremacist violence in Charlottesville.

Trump — who has fumed at the media’s criticism of his response to Charlottesville — is also annoyed at similar criticism coming from within his administration, especially from National Economic Council Director Gary Cohn and Secretary of State Rex Tillerson, according tolong before it had any real idea what to do with it. Not so with state and local transportation departments and agencies, who are so used to taking money when it’s offered that they have ready-dug pie-in-the-sky holes they can throw it in, depending on the size of the check.

Conservatives putting the brakes on projects, wanting to get more for the money or be sure the projects aren’t really pre-dug black holes, may just be a good thing to let us step back and make sure the funding is directed to projects that, in the near term – say a decade – have a chance of success.

Sunday, October 17, 2010

It's amazing how a single development - make that a singular development - can change a lot of things


conservative free enterprise rule.

Rail is a mode of transportation that has always been too important to the economy and general well being of Americans to allow it solely to free enterprise. Witness the years that the feds have spent regulating railroads, first with antitrust action, next with the ICC, and now through the STB. Well, some things are also too important to leave Free Enterprise alone in the same room with. Passenger Rail is one of those things.

Unfortunately, instead of alone with Free Enterprise, via Amtrak, we have left Passenger Rail alone in the same room with Government Excess.

Why are there no compromise positions any more?

For two reasons: 1. Both the right and the left have decided that politics is no longer a system of compromise. 2. Underthe banner of political principle, the voting populace has gone along with them.

Where are the people who can see the Constitution as one giant compromise of many different political points of view? It is a compromise that worked and that is still working. A similar compromise for Passenger Rail would require free enterprise to invest in Passenger Rail just as much as it would require government to give free enterprise a helping hand. The way I see it now, too much of the funding for Passenger Rail goes to government entities to spend. What is spent on private enterprise – and there appears to be a lot of it vying for the right to build new HSR infrastructure – is spent on government connected companies working under government


specifications. This stifles innovation.

I am no more demanding that the government stop using tax money for transportation subsidies any more than I am asking private enterprise to fund new rail routes without tax money subsidies. I am hoping for that grand comprise – embodied by our Constitution – that will get us there in new and innovative ways. Without the political radicalism.

Sunday, September 12, 2010

I've recently been reading two books that have everything to do with Passenger Rail but nothing to do with Passenger Rail in the 21st century. The first of these is a book called Super by Jim Lehrer. Yeah, the same Lehrer who is a news commentator. It's a novel that takes place aboard the Super Chief and environs in the 1950s. I got anof government intervention to research and develop and invent, but they will always need the government as the last, best source of funding for that great leap into the new frontier. Our government is – after all – the people. And we, the people, will take us there. I criticize, but I have no doubt.

If you like Passenger Rail as a transportation mode, you should read the whole study. It’s a great example of good investigation, science and research. Some of the climate-change people should take it as an example. It doesn’t paint rail transit in a very good light for those of us who would like to see reduced government size and cost.

If you are a railfan, some of the criteria Mr. O’Toole uses for viable rail


than - those we got from the Interstate system. What were those? Foremost, they got a lot of people into, and out of, major population centers fast. Secondarily, they created markets. In the case of HSR, the market will be for surface transportation of people and goods. Yes, Virginia, goods! Express and package freight will find a home with HSR just as it did with the redundant passenger routes of the classic railroad past. Suddenly, rail would be an alternative for LCL freight. Nothing wrong with building HSR baggage-mail cars.

Thirdly, the Interstate system drew development out of the dead middles of small towns. Of necessity, the HSR stops won't be in many of the smallest of towns. But for small and mid-sized cities, HSR stations will be intermodal.guy Dad would be like in high school?" "Paul Kolsenovic." "What?" "Paulie K?" "I was never a shortstop." " Dad, he's a total asshole." " What?" "Guys like that are allergic to people like us." "They make mooing sounds when we walk past." "What's up with you guys?" "I never mooed at anybody." "Paulie K calls me Gaymon." "What?" "That kid just got benched." "Dad, you don't get it." "You think you would've been friends with us in school?" "Absolutely." "Of course." "I always had interesting friends." " Oh, like who?" " Like" " Well...." "Like my friend Tanya, for example." "We do stuff together all the time." " Like what?" " Interesting stuff." "What's the matter with you guys, huh?" "Why am I the enemy all of


trying to fuck with my head and I need to fight back." "I see." "You're very excitable." "Well, for example, this sweater." "I think she practically cursed it." "I think she went so far as to sneak into my apartment and switch it out with a cheaper version." "I am absolutely positive that this label used to say "Lanvin," and now" "Hold." "Take her out." " The other pimp." " Take her out?" "Uh-huh." "That's what I want to do." "Not in a violent way." "Hey." "Okay, this is how I do it." "Close your eyes." "Really, close your eyes." "Now imagine this lady." "Imagine the colour of her hair." "Wait, wait." "Okay." "Good." "Her eyes." "Well, everything." "You got it?" "Yeah." "Now see her dead." "See everyto buy this one and it was clearly so much nicer." "I'm sorry you're disappointed." "I really am." "I would be too if I discovered that my § 1800 gift was a Lankin." "Although Lankin is a well respected emerging Israeli designer who just happens to favour cheap rayon." "That's it." "That's it." "I am sick of it." "I am sick of your shit." "I am sick of you, Lenore." "I have tried to make this work." "I tried to be a gracious person when you swooped in and took Ray away." "But I'm so tired of being gracious." "I am sick of being accommodating." "I am tired of being walked all over." "You think you're the only one who can play hardball?" "I know how to play


if it wasn't, I sure deserve it." "I'm being melodramatic." "How can I help you?" "I want to help you." "Jessica." "Oh, it's my" " My friend." "I called her." " Hi." "I thought you said you were here alone." "No." "I'm" " I was talking to" "This is my ex-husband, Ray." " We're friends." " I can see that." "Hi, I'm Lenore." "Hi, I'm Ray." "Hi."Van der Bellen, an aged professor backed by the Greens. Mr Hofer is the favourite, and the rest of Europe is alarmed.

The FPÖ operates from a familiar populist-right playbook. The suits have grown sharper while the outright racism has been cloaked. The hostility has shifted from Jews to Muslims, a strategy that resonates with voters of Serbian background, whom the party has assiduously cultivated. Its leaders prefer social media to the traditional kind. Its base is poorly educated rural men. It has no good words for America but plenty for Vladimir Putin.

If he wins, Mr Hofer is unlikely to wreak constitutional havoc. But should Heinz-Christian Strache, the FPÖ’s chairman, become chancellor at the next federal election (due in September 2018, if not sooner), some fear a Hungarian-style attack


must yield."); Carson v. Oxenhandler, 334 S.W.2d 394, 397 (Mo.Ct.App.1960); State ex rel. Volker v. Carey, 345 Mo. 811, 136 S.W.2d 324, 325 (Mo.1940) ("When the ordinances or charter provisions are or become in conflict with prior or subsequent state statutes, such ordinances or charter provisions are or become, void, and must yield to the higher law.") (emphasis added). The City, as a political subdivision of the state, cannot exceed the authority granted by the state and must accept the state's election to limit that authority. See Missouri ex rel Kemper v. St. Louis, Kansas City, & N. Ry. Co., 9 Mo.App. 532, 1881 WL 175, *3 (Mo.Ct.App.1881) ("[I]t is competent to the Legislature to modify [municipal powers] at pleasure, or to take them wholly away.").

11
Third, the Cityplus cones and other toppings.

You will also find sandwiches, milkshakes, yogurts, real fresh fruit freezes and novelty items like chocolate covered bananas, mud pie on a stick and clown cones.

Gunther’s has been at the same address at 3rd Avenue and Franklin Blvd since 1949. Same wooden booths. Same neon sign of Jugglin Joe perched on the roof tossing a ball of ice cream from scooper, over his head, to cone.

There is another venerable ice cream shop in the area: Vic’s. And there is the inevitable debate on whose product is better. My answer: who cares?

I will leave Vic’s to its fans and stick with Gunther’s ice cream sundaes. Judging from the smiles other than mine at Gunther’s, I would say a lot of folks feel the same way.


                        9

is limited to benefits from tax-preferred plans and
the Excess Plan is not tax preferred.
  The clincher to this interpretation is the plan admin-
istrators’ consistent, unchallenged practice over many
years of using the 7.5 percent figure to calculate lump
sum benefits under the Excess Plan. When the con-
sistent performance of parties to a contract accords with
one of two alternative interpretations of the contract,
that’s strong evidence for that interpretation. This is a
general principle of contract interpretation rather than a
provision of ERISA, 2 E. Allan Farnsworth, Farnsworth on
Contracts § 7.13, pp. 329-30 (3d ed. 2004); Restatement
(Second) of Contracts, § 202, comment (g) (1981), but it is a
principle thatwill rename them from what ever to Number-rom name like some I already have. I have the nds dat file for it also and that is loaded in , as the list of all releases came up in the box on the left.

So how do I do it? , all I want is it to rename my roms . Guide or anything? , or someone just tell me how .


Son IlRak’s Cyworld Update, 101205

I went out with my wife to Chunho Department Store for shopping~~~
The phone rings.
Aigo~~~ It’s Dongwoon~~~

Dad, we won Mutizen Song~~~Really~~~? Congratulations. Mom and Dad couldn’t see it because we were outside~~~ Sorry~~~

On here my wife and I felt really sorry and disappointed for missing the broadcast. ^^

So, you went to Singapore and came back as you would go to a neighborhood~~~ Are you alright?

(with a cheerful voice)Yes~~~ I’ll see you

My wife and I quickly went home and saw today’s broadcast and ancore performance uploaded on bestiz.

Today they were especially bling bling, armed with pinky~~~ And seemed like pros~~~
I’m very proud.
Besides, I’m pleased to hear that they won 1st place with the song Beautiful which I think is dedicated to the B2UTIES.

But my wife threatensalerted to the shootings just before 8 a.m. when Pike County dispatchers received a 911 call reporting two men were possibly dead at a home at 4077 Union Hill Road in Peebles. As officers responded, they were flagged down and alerted to two more crime scenes also on Union Hill Road - 4199 and 3122, Reader said. Authorities said two of the homes were in short walking distance, and the third was about a mile away.

Seven people were found slain in the three homes. Reader said he contacted the attorney general's office and asked the state Bureau of Criminal Investigation to lead the investigation because of the multiple crime scenes.

Later in the day, authorities received another 911 call alerting them to another possibly deceased man at a home


  She saw Appellant and Jacobs enter the store with
          guns and masks and immediately said to Appellant,

                                  -2-
J. S61004/14

          “[M]y daughter is in the store, please don’t shoot.”
          Id. at 62. Appellant responded, “We won’t, we
          won’t.” Id. at 63. Christina R. heard Appellant
          threaten to kill LloydH. while holding a gun to his
          head and saw Daniel H. open the safe while Jacobs
          was pointing a gun at him. After the robbery, she
          stayed behind and also observed Appellant and
          Jacobs, who were unmasked, running through the
          parking lot of the Family Dollar soon after the crime.
          At trial, she identified Appellant as the man who held
          the gun to Lloyd


the issues are

meritless.   Widgins, 29 A.3d at 818, quoting Pitts, supra at 2 n.1, 981

A.2d at 876 n.1. This court must then conduct its own independent review

of the record and agree that the petition is meritless. Id. Finally,

             PCRA counsel who seeks to withdraw must
             contemporaneously serve a copy on the petitioner of
             counsel’s application to withdraw as counsel, and
             must supply to the petitioner both a copy of the
         -6-
J. S61004/14

Id., quoting Commonwealth v. Friend, 896 A.2d 607, 614 (Pa.Super.

2006) (citation omitted). In this case, the foregoing requirements were met,

and appellant has not responded to PCRA counsel’s motion to withdraw. We

now turn to an independent review of the issues presented to determine

whether they have merit.

      Initially, we recite our standard of review:

            This Court’s standard of review regarding an order
            denying a petition under the PCRA is whether the
            determination of the PCRA court is supported by the


          and r.e.a.d. The defendant did not commit these
              charges and will plea not guilty at his hearing. The
              Defendants co-defendant, Jamal Jacobs, is will to
              testify on, Gerald Mar, behalf. Stating that he does
              not know defendant, Gerald Mar, personally nor did
              he take part in committing these alleged crimes.

Certified record, Document #48.

loans and rising interest rates to private financial companies, who then lend the money to the students. Either way, taxpayers are on the hook.

Which means either way, it’s a government program. When Graham charges that Democrats are “giving the student loan program completely to the federal government,” he is making zero sense — unless he believes that the banks have some entitlement that we weren’t told about.

Republicans (and a few Democratic accomplices) are defending a real sweet deal for Wall Street. The companies make fortunes off the student borrowers while the taxpayers protect them against their bad luck.

This is another of those “privatized profits and socialized losses” schemes that enrich the financiers no matter what happens to the rest of us.

Do you know who would lose billions should


Phoenix. This “could be read as a message to Lynch that she’d better not charge Hillary if she expected to keep her job.” Bill Clinton didn’t even have to discuss the email server investigation with Lynch, as pointed out by the embedded reporters on the Hillary campaign in their sympathetic postmortem book Shattered.

But conservatives, they note, already “had pretty good circumstantial evidence that the Obama Justice Department and the Clinton [campaign] operation were coordinating on the e-mail scandal.”

Interestingly, this damning email the FBI obtained—about their boss Lynch rigging the Hillary email-server investigation—was never part of the WikiLeaks emails leaked from the Democratic National Committee (DNC) and Hillary campaign chair John Podesta, or the “Trump dossier’s” schizo-conspiracy. So where did it come from?

The New York Times claims that unnamedseem archaic or at odds with the contemporary world; the protesters seem more in tune with modernity than the methods of their rulers. Sociologist Keith Kahn-Harris calls what we're seeing the "movement without a name": a trend, a direction, an idea-virus, a meme, a source of energy that can be traced through a large number of spaces and projects. It is also a way of thinking and acting: an agility, an adaptability, a refusal to accept the world as it is, a refusal to get stuck into fixed patterns of thought. Why is it happening now? Ultimately, the explanation lies in three big social changes: in the demographics of revolt, in technology and in human behaviour itself.

At the centre of all the protest movements is a new sociological


given today's protest movements a massive psychological advantage, one that no revolt has enjoyed since 1968.

Suddenly, the form of today's protests seems entirely congruent with the way people live their lives. It is modern; it is immune to charges of "resisting progress". Indeed, it utilises technology that is so essential to modern work and leisure, governments cannot turn it off without harming their economies. And, as Mubarak, Gaddafi and the Bahraini royals discovered, even turning it off does not work.

Because – and here is the technological fact that underpins the social and political aspects of what has happened – a network can usually defeat a hierarchy.

The pioneer of network theory, Walter Powell, summed up the reasons for this as follows: the network is better at adapting to asituation where the quality of information is crucial to success, but where information itself is fluid; a hierarchy is better if you are only transmitting orders and responses, and the surrounding situation is predictable.

Once information networks become social, the implications are massive: truth can now travel faster than lies, and all propaganda becomes instantly flammable. Sure, you can try to insert spin, but the instantly networked consciousness of millions of people will set it right: they act like white blood cells against infection so that ultimately the truth, or something close to it, persists much longer than disinformation.

Whereas the basic form of, say, a Leninist party, a guerrilla army or even a ghetto riot has not changed in a century, once you use social networks the organisational format


Hoban is bringing its own great tradition, aiming to win its 4th straight title. St. Ignatius has the record of five straight. Get your tickets now at https://www.profootballhof.com/events/2018-ohsaa-state-football-championships/#Tickets Kickoff is 8pm Thursday night November 29th.

The marquee matchup is Cleveland St Edward’s, who has won three titles since 2010, facing Cincinnati Colerain, Friday night at 8pm. St Ed’s has won three state titles since 2010.

Saturday starts with the Division VII title tilt, Glouster Trimble vs McComb at 10am, followed by Division V championship at 3pm with Johnston-Monroe taking on Orville. The finales at 8pm is undefeated Cincinnati Wyoming vs Girard.

All games will be on Spectrum and HOF Productions will produce the Scoreboard feed for the games, pregame and halftime.Q:

lex: default rule for unrecognized strings

In ocamllex, I can use _ as a lexer rule to match any string that does not match previously defined rules, and raise errors. How can achieve this in lex/flex?

A:

Typically, you would define a rule like this, which would go at the very end:
.|\n         { /* process default here */ }

This rule will match any character that wasn't matched by any other rule.
Hope this helps!


floated on the stock market in 2006 by its then-private equity owners, Texas Pacific Group, CVC, and Merrill Lynch Private Equity:

The latest rejection means that Debenhams, after gracing British high streets for over 200 years, now faces a “pre-pack” administration that will wipe out its shareholders, including Sports Direct which is estimated to have plowed at least £150 million into the firm.

On its corporate website Debenhams stated that while the Group’s holding company has gone into administration, its operating companies “continue to trade as normal” and its commercial stakeholders, including suppliers, are not adversely impacted by the Company’s administration. “We remain focused on protecting as many stores and jobs as possible, consistent with establishing a sustainable store portfolio in line with our previous guidance.”

Debenhams had given Sports DirectQ:

Averaged dot product

In one of the textbooks I came across this:
"the average over the angles of the scalar product such as $(\vec{n} \cdot \vec{a}) (\vec{n} \cdot \vec{b})$ is equal to $\frac{1}{3}(\vec{a} \cdot \vec{b})$"
The author also gives the average of $(\vec{n} \cdot \vec{a}) (\vec{n} \cdot \vec{b})(\vec{n} \cdot \vec{c}) (\vec{n} \cdot \vec{d})$ which is equal to $\frac{1}{15}[(\vec{a} \cdot \vec{b})(\vec{c} \cdot \vec{d})+(\vec{a} \cdot \vec{d})(\vec{c} \cdot \vec{b})+ (\vec{a} \cdot \vec{c})(\vec{b} \cdot \vec{d})]$.
In all of these $\vec{n} = \vec{r}/r$ and $\vec{a},\vec{b},\vec{c},\vec{d}$ are constant vectors. How to prove it? What does "average over angles" mean, just $d\theta$ and $d\phi$ or the full spherical angle $d\phi \;d\theta \sin \theta$?
Thanks in advance!

A:

First formula :
Here are two different proofs :
Method 1 :
Let $u \cdot v$ denote the dot product of $u$ and $v$.
Using expansion :
$$(n \cdot (a-b))^2


missing information.

Many governments are experimenting with coverage evidence development (CED) or comparable schemes \[[@ref9]\]. The arrangement aims to solve the problem of providing fast access of promising new medical technologies, while the underlying data may not be complete in all aspects. Often this means a period of formal introduction and coverage by the national health insurance or by special government funding, in combination with prospective or controlled research and registration (and follow-up) of patient data. Alternatives that are especially considered in the case of expensive new cancer drugs are 'pay for performance', 'no-cure no-pay', or 'risk-sharing' schemes \[[@ref10]\].

In The Netherlands, the government has experimented with an early schedule of CED in which initially a few procedures were included combined with rather large funding of research programs on thosecosts (excluding capital overheads), a band 5 nurse may cost around £53,000 a year.

That doesn’t include the cost of recruiting or training those nurses, which is a significant factor in how much such a policy would eventually cost. Estimates suggest over the expected lifetime service of a nurse, that could amount to around £8,700 a year.

Even without adding training costs, as a very rough indication, 50,000 nurses at pay band 5 cost the NHS in the region of £2.8 billion a year based on this estimate (or £2.6 billion excluding capital overheads). The actual cost will be higher as some move up the pay scale, and considering ongoing training costs as well.

But how far would 50,000 nurses go?

In August 2019 (the most recent figures we have) there were


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Rise up your darkness

The MT-07 is a new kind of motorcycle that is designed to bring fun, affordability and enjoyment back to the street. And just about everything about this versatile new naked bike - from its deep torque through to theCobb, 211 N.C. 146, 189 S.E. 479; America Potato Co. v. Jeanette Bros. Co., 174 N.C. 236, 93 S.E. 795; Allen v. Roanoke R., 171 N.C. 339, 88 S.E. 492. The equitable right to reformation may be invoked by a defendant by way of defense or counterclaim in an action based on the deed. Cuthbertson v. Morgan, 149 N.C. 72, 62 S.E. 744; Manufacturing Co. v. Cloer, 140 N.C. 128, 52 S.E. 305; McLamb v. McPhail, 126 N.C. 218, 35 S.E. 426.
The defendant does not seek to correct the deed for mutual mistake. He alleges with particularity in his counterclaim, however, that the name of the plaintiff was erroneously inserted in the deed as a co-grantee at his instance because of a mistake on his part superinduced by


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bad knees, apparently met with the Lakers for three hours last week to determine if there was any mutual admiration. Most bizarre is how the Lakers reportedly were trying to sell him on more playing time, more money and a “better environment” than what Rose endured last season in New York.

Oh, and could you mentor our new rookie point guard Lonzo Ball? Sure, but then who would babysit Rose? LaVar?

Plans for this Sunday’s column are to feature Claire Smith, the first woman to receive the J.G. Taylor Spink Award Winner for writing excellence by the Baseball Hall of Fame. She receives the award on Saturday (MLB Network will have a one-hour taped highlight show on Sunday at 8 a.m., prior to its Hall of Fame induction ceremony livewould represent, where his father was a union organiser. He insisted his son, a jazz aficionado, should not become a musician.

Jazz remained one of Conyers’ “great pleasures”. He sponsored legislation to forgive the $1.6m tax debt of band leader Woody Herman’s estate and once kept a bass in his Washington office.

Before heading to Congress, Conyers served in the national guard and with the US Army Corps of Engineers during the Korean war, supervising aircraft repairs. He earned degrees from Wayne State University in the late 1950s.

From 1958 to 1961 he worked as a legislative assistant to John Dingell, another Michigan Democrat who when he retired in 2014 at 88 was the longest-serving member of Congress, a mantle that passed to Conyers.

In 1964, Conyers won his first congressional election


cause.

Facebook Twitter Pinterest On 23 July 1967, Conyers uses a bullhorn to encourage African Americans in Detroit’s riot area to go home. Photograph: AP

He used his influence to push civil rights. After a 15-year fight, he won passage of legislation declaring Rev Martin Luther King Jr’s birthday a national holiday, first celebrated in 1986. Starting in 1989, he regularly introduced a bill to study the harm caused by slavery and the possibility of reparations. It never got past a subcommittee.

Conyers’ office in Detroit employed the civil rights legend Rosa Parks from 1965 until her retirement in 1988. In 2005, Conyers was one of 11 people inducted to the International Civil Rights Walk of Fame.

In 2013, he was fiercely opposed to Detroit being taken over by a state-appointed emergencypatients, it is important to collect familial and pathological history information for family members. It would be useful to know if they could be involved into other not cancer-related disease processes, and here we would like to stress the importance of collecting also a detailed non-oncological history to deepen the knowledge even on the plane of not cancer disease, from a medical point of view, and to define if BAP1 mutations could be also associated with specific metabolic disorders or other internal disease predispositions. Henceforward for this reason, to reach the goal more multidisciplinary clinical studies are needed. In practical terms, in the current state of knowledge, patients who are offered BAP1 testing on their tumors should first have genetic counseling so that the occurrence of an inherited


the oppressiveness of the Wall. Instead of a view of the west you see a wasteland of weeds and lampposts and behind them another concrete sheath, the second wall that was erected right next to West Berlin territory.

For an extensive view of the former death strip climb up the recently opened tower at the nearby Berlin Wall Documentation Center to the viewing platform. The Documentation Center tells the history of the Wall, and the adjacent Chapel of Reconciliation recalls the Protestant church that was off-limits to the public after the Wall was built on either side of it. The disused church was torn down 24 years later.

Checkpoint Charlie

The first guard house at Checkpoint Charlie is erected.

More wall -- this time just one layer -- can be found onthe market, sample tissue from a biopsy region according to either one of the processes (1) or (2). The biopsy needle has a sampler for sampling tissue under suction, at a position that is slightly offset from the tip end thereof toward the proximal end thereof.
A biopsy apparatus that operates according to the vertical piercing process is capable of sampling tissue from a biopsy region in a breast that is relatively thick. However, when the sampler of the biopsy needle is aligned with a biopsy region in a relatively thin breast and the biopsy needle is inserted into the biopsy region, the tip end of the biopsy needle tends to pierce through the relatively thin breast (see FIG. 13C of the accompanying drawings). According to the vertical piercing


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  // grey color don't change saturation
  if (hsv.h === 0 && hsv.s === 0) {
    return hsv.s;
  }
  letAnswered by:

"Failed to start live mesh" message

Question

I cannot get live mesh working on my xp laptop. I continually get the "failed to start live mesh" error after installing/reinstalling. However, when I create a new user account, live mesh will install and I can log into my mesh (which currently has 3 other computers). What am I doing wrong and why isn't there any solutions on the internet?

Monday, July 28, 2008 6:58 AM

Answers

If you encounter this problem, please submit a bug report with your logs. We're working hard to determine the cause(s) here, and any additional information would be helpful. As always, instructions for submitting a bug report with logs are at the top of the forums.

All replies

I dont suppose you have or have had an apostrophe in the


the fact I have a hamachi VPN program running all the time. I have had a bit of a poke around in some log files, but they don't tell me too much? Where to look for detailed error information.

I've got a vista SP1 machine that installs live mesh just fine, but it refuses to start. 2 possibilities I can think of are I am running framework 3.5 SP1 beta or the fact I have a hamachi VPN program running all the time. I have had a bit of a poke around in some log files, but they don't tell me too much? Where to look for detailed error information.

If you encounter this problem, please submit a bug report with your logs. We're working hard to determine the cause(s)thing that MrScience and me did the same. Only that I've uninstalled and than removed from network, and MrScience first removed from network, than uninstalled.. but perhaps any combo works. And if that solves your problem, I sure hope a lot of other people will have the same luck.

Thanks for the update, MrScience101. Yes, a removal from the Mesh and a reinstall is often a good "hit it with a hammer" solution. It may have been some issue with Hamachi, but I don't think so. And, based on your log, there was no spyware, just tracking cookies.

I had the same "failed to start" message yesterday (4/6/2010) on one, not both of my computers that have Mesh. By experience, I immediately went to the same solution: delete from Mesh,


minimum. Not leaving any excuses as to why he shouldn’t get called up.

I don’t understand how blatant exaggeration has become a valid means of making your point but, yes, he can skate, he just doesn’t have the speed it seems the new NHL is going toward. If I remember well he isn’t slower than TVR – not something to brag about.

The Leddy deal really seems like a huge miss by Stan Bowman at this stage. Yes SB was up against it at the time yes! However trading a young,player that evolved into a top pair D-Man for a marginal prospect isn’t a good regardless of the situation. I’m not sure if Pokka is an NHL player.

Don’t know if its a coincidence or not but the recent rfa signingstime you’ve ever heard anyone say “IT Applications & Operations”? Frankly, in my 30+ year career in IT, I don’t believe I’ve ever heard anyone use this term. The typical term we hear is IT Infrastructure & Operations. These two go together like Peanut Butter and Jelly, which tells us a lot about how we view the field of IT. For those that may not be familiar with the role of IT ...

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