in such a way that the active portion of the formulation is released in the gastro-intestinal tract when bioavailability is maximized and pre-systemic degradation is minimized. The formulation can also include further excipients with the aim of facilitating absorption of the active principle. It is also possible to use diluting agents, flavouring, low melting-point waxes, vegetable oils, lubricants, suspending agents, capsule disintegration agents and binding agents.
Independently of the method of administration, the specific dose is calculated according to the approximate body weight of the patient. Further refinement of the calculations necessary to determine the appropriate dose for treatment is routinely made by those of ordinary skill in the art, who are capable of reaching these results without the need for undue experimentation, especially in the light of thefloor of the vehicle and extends upwardly to a meet a mounting platform at the top, to which is docked the computer via manual drop-and-click locking mechanism. There is no assurance that proper mechanical and electrical connection between the portable computer and the mounting platform has been successfully achieved until one attempts to use computer. It is not uncommon for these connections to be faulty or inadequately effected, thus necessitating the user to perform the docking task one or more times.
The pen-based portable computer of the invention overcomes all of the above-described shortcomings of the prior art, and provides a number of beneficial and novel additions that provide a pen-based portable computer that is more reliable, easier to use, and which provides for the possibility of exchanging components


Candidate: Dr. Michael Mathis is a cardiothoracic anesthesiologist with board certification in anesthesiology and advanced perioperative echocardiography at the University of Michigan. Through completion of a T32 Research Training Grant, Dr. Mathis has developed expertise in perioperative outcomes research for patients with advanced cardiovascular disease. His long-term career goal is to improve care for patients with heart failure (HF) through harnessing perioperative electronic healthcare record (EHR) data for early diagnosis and management. This proposal builds on Dr. Mathis's expertise, providing protected time for training in data science methods necessary to drive forward the analytic techniques proposed for improving HF diagnosis. Environment: The University of Michigan is the coordinating center for the Multicenter Perioperative Outcomes Group (MPOG), an international consortium of over 50 anesthesiology and surgical departments with perioperativeantidepressants. More than one-half (51.1%) of patients were treated with anticonvulsants. Benzodiazepines and antipsychotics were dispensed to 17.3% and 15.8%, respectively. For MS medicines, 804 were prescribed for 48.1% (64/133) of veterans. Nearly one-fourth (24.8%) were treated with skeletal muscle relaxants. The CNS and MS medications, in general, were continuously prescribed over the 12-month study period. This study provides insight into the complex medical management involved in the care of veterans with BRIs.


unprecedented move to eliminate blight in our downtown and to create new and attractive ‘for sale’ housing to truly meet our goals for Restoring Central Dover,” said Joe Myer, executive director of NCALL.

In March, NCALL and Central Delaware Habitat received a joint award of $1 million in Strong Neighborhoods Housing Funds to redevelop 20 properties in Central Dover. Most of the homes that were acquired were known nuisance properties, as well as magnets for crime and illegal activity.

The lots will eventually be redeveloped and then sold to qualifying homebuyers. Both NCALL and Habitat are focusing efforts on specific blocks to ensure maximum impact of their investment.

“In a relatively small area, this concentration of demolition and revitalization will have a major impact on the look of the community, the  http://computername:port
http://subdomain2.domain.com  Default   http://subdomain2.domain.com
http://computername:port2   Default   http://computername:port2

...Some explanation:
ComputerName is the name of the server.
HostName is just a single hostname DNS entry we have so people can quickly type for example "Sharepoint" in their address bar.
Subdomain is basically sharepoint.ourdomain.com.  pretty self explanitory
Subdomain2 is for our Business Intelligence services server.
We have two entries with port numbers.  One goes to central admin.  the other gives an error and i'm not sure what its used for (if anything).
I inherited support of this application.  I hope things arent too messed up.
So TLDR: How can I get HTTP and HTTPS working seamlessly together inside/outside our network to avoid missing images and invalid links?
Thanks all.

A:

The problem is that the urls in the links and


Bill Goldberg Talks About His Recent Negotiations with Triple H, Is He Open To A WWE Return?

PWInsider spoke to Bill Goldberg shortly before WWE’s WrestleMania XXX pay-per-view earlier this month. Regarding the rumors of possibly returning to face Ryback, Goldberg says he had a few talks with Triple H but none of them were specifically geared towards WrestleMania and none of their talks had to do with Ryback. Goldberg described the talks as general conversations that didn’t lead anywhere.

Goldberg says he still trains, maybe more than he ever has in his life, and had the following to say about a possible return:

“Would I love to do it again and have my son and my wife, who has never seen me wrestle? Abso-damn-lutely. Would I jeopardize what I’ve doneOLEDDisplayUi::enableAutoTransition(){
  this->autoTransition = true;
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void OLEDDisplayUi::disableAutoTransition(){
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}
void OLEDDisplayUi::setAutoTransitionForwards(){
  this->state.frameTransitionDirection = 1;
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void OLEDDisplayUi::setAutoTransitionBackwards(){
  this->state.frameTransitionDirection = -1;
  this->lastTransitionDirection = -1;
}
void OLEDDisplayUi::setTimePerFrame(uint16_t time){
  this->ticksPerFrame = (int) ( (float) time / (float) updateInterval);
}
void OLEDDisplayUi::setTimePerTransition(uint16_t time){
  this->ticksPerTransition = (int) ( (float) time / (float) updateInterval);
}

// -/------ Customize indicator position and style -------\-
void OLEDDisplayUi::enableIndicator(){
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void OLEDDisplayUi::disableIndicator(){
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}

void OLEDDisplayUi::enableAllIndicators(){
  this->shouldDrawIndicators = true;
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void OLEDDisplayUi::disableAllIndicators(){
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}

void OLEDDisplayUi::setIndicatorPosition(IndicatorPosition pos) {
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void OLEDDisplayUi::setIndicatorDirection(IndicatorDirection dir) {
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void OLEDDisplayUi::setActiveSymbol(const char* symbol) {
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void OLEDDisplayUi::setInactiveSymbol(const char* symbol) {
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// -/----- Frame settings -----\-
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void OLEDDisplayUi::setFrames(FrameCallback* frameFunctions, uint8_t frameCount) {
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this->state.frameState = IN_TRANSITION;
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// -/----- State information -----\-
OLEDDisplayUiState* OLEDDisplayUi::getUiState(){
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int8_t OLEDDisplayUi::update(){
  long frameStart = millis();
  int8_t timeBudget = this->updateInterval - (frameStart - this->state.lastUpdate);
  if ( timeBudget <= 0) {
    // Implement frame skipping to ensure time budget is keept
    if (this->autoTransition && this->state.lastUpdate != 0) this->state.ticksSinceLastStateSwitch += ceil(-timeBudget / this->updateInterval);

    this->state.lastUpdate = frameStart;
    this->tick();
  }
  return this->updateInterval - (millis() - frameStart);
}

void OLEDDisplayUi::tick() {
  this->state.ticksSinceLastStateSwitch++;

  switch (this->state.frameState) {
    case IN_TRANSITION:
        if (this->state.ticksSinceLastStateSwitch >= this->ticksPerTransition){
          this->state.frameState = FIXED;
        break;
      case 2: // Indicator was drawn in this frame but not in next
        // Slide OUT
        indicatorFadeProgress = ((float) this->state.ticksSinceLastStateSwitch / (float) this->ticksPerTransition);
        break;
    }

    uint16_t frameStartPos = (12 * frameCount / 2);
    const char *image;
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ART coverage creates an urgent need for a strengthened laboratory support network for early diagnosis of HIV, timely monitoring of HIV treatment and early detection of resistance due to failing ART regimens.

Despite existing evidence and the 2013 WHO recommendations that VL testing is crucial in predicting clinical outcomes among PLWHAs taking ART \[[@pone.0145110.ref004]\], implementation considerations are inhibiting the scale up of this technology in sub--Saharan Africa. A recent report indicates that less than 20% of African patients on ART have access to a VL testing \[[@pone.0145110.ref005]\]. Costs and complexity are often prohibitive due to expensive VL detection equipment, the need for human resource training and laboratory infrastructure as well as operational challenges in sample collection, transport, storage and processing. Notwithstanding, the WHO makes a strong recommendation that VL5,000 copies/mL, our primary cut-off point, was 27.0% (95% CI: 22.9%--32.9%) as determined by the gold standard VLref assay and depicted in [Table 2](#pone.0145110.t002){ref-type="table"}. VFA compared to the VL~ref~ demonstrated 78.4% sensitivity, (95% CI: 69.7%--87.1%), 93% specificity (95% CI: 89.7%--96.4%) and 89.3% accuracy (95% CI: 85%--92%). The AUC was 0.91 (95% CI: 0.88--0.94) whilst the kappa agreement between VFA and VL~ref~ was 72.2% (95% CI: 61.1%--83.4%). The predictive value of positivity and negativity were 81.3%(95% CI: 72.9%--89.8%%) and 91.8% (95% CI: 88.2--95.4%) respectively. The likelihood ratio for a positive test was 11.3 (95% CI: 6.87--18.5) while that for a negative test was 0.23 (95% CI: 0.16--0.35). The Diagnostic Odds Ratio was 48.5 (95% CI: 13.1--84.0). The Area Under Curve (AUC) was 0.91 ([Fig 1](#pone.0145110.g001){ref-type="fig"}).

![Receiver Operating Characteristics Curve for


therapy. The VFA generally demonstrated better receiver operating characteristics at a higher viral load threshold of 5,000 copies/mL, consistent with a recent systematic review \[[@pone.0145110.ref020]\]. In fact, this review showed that specificity was close to 100% at DBS VL above 5000 copies/ml, and this threshold would be the most reliable for predicting true virologic failure using DBS \[[@pone.0145110.ref020]\]. This puts into perspective the current definition of VF by WHO set at 1000 copies/ml \[[@pone.0145110.ref004]\] and questions whether this decision results in ineligibility of (promising) in house VL tests and in fact slows down roll-out of VL monitoring in RLS.

The finding that the VFA performed better in adults than children at our higher primary threshold of \>5,000 copies/ml remains a paradox; particularly in light of the documented higher VLidentities and views them as a strength.”

This understanding sheds light upon a particular pattern found in the English-speaking countries of Australia, Canada, New Zealand and the United States, as well as Ireland… all of which generally rank right behind the Scandinavian countries. They are equal to the Nordic countries in terms of perception of fairness, and outperform them on solidarity and helpfulness.

It is interesting to note that conditions in these countries are quite different from conditions in the Nordic countries; for example, their welfare systems are less active in redistributing wealth, and their societies are characterized by a larger gap between rich and poor. But… as immigrant societies, the non-European countries are ethnically and religiously diverse; multicultural policies are in place to manage that heterogeneity.

In this group, also,


derailed Trump's presidential campaign last year. "And we have to think about, ‘Ok, in the normal universe where gravity exists, this is not survivable.' But in his world, gravity does not exist, so I think it could be survivable, but he has to stop talking about it."

Several sources inside and outside the White House said Trump's decision to take questions after his infrastructure statement on Tuesday came as an unwelcome surprise to his staff. A White House official distributed talking points and research materials to allies shortly afterward that focused solely on infrastructure and construction permitting, according to copies obtained by the Washington Examiner, underscoring the degree to which aides believed the day would produce media coverage of infrastructure only.

Gary Cohn, Trump's chief economic adviser, was particularly upsetthing," one person close to Kelly said of Trump's beleaguered chief of staff. "I don't know what he's going to do, but a lot of people are telling him, ‘Just stay in because as bad as things are, the country needs you and needs stability.'"

The person said Kelly may have erred by allowing ambiguity to surround the White House's messaging strategy.

"I think he made a very strategic error when he came on in that he didn't establish a set of preconditions with the president as to how things would work, especially on the communications side," the person close to Kelly said. "And now that communications aren't consistent, people in the White House don't feel like they're being taken seriously."

Another source close to Kelly said the Charlottesville imbroglio has


repeatedly attest to the good that the
tempo and structure brought to the organization and customers.

~~~
overgard
It sounds like you had a bad manager, but no methodology can fix that.

My entire experience has been: good management + talented developers =
success, and bad management or untalented developers and it fails, but it
really has nothing to do with the methodology in play. I've seen (and been
part of) hard core agile teams burning to the ground, and teams with no
methodology be wildly successful. (And vice versa)

Agile bothers me because it generally aims to commoditize developers, and yet
the best places and teams I've worked on always were they opposite: it was
about finding the best way for each individual to work, and designing
processes around the rhythms around whatever industry they were working in,
rather than assumingknow how to do.
Yet.

You don't figure those things out until long after someone wanted an estimate
and tonolan release date. It's not infrequent to have shipped v1 before you
figure out how things work. Or needed to work.

The quite "no plan survives contact with enemy" applies to softdev as "no
design survives contact with production"

~~~
commandlinefan
> estimation is a skill

I've seen a lot of people suggest variations of this, but after 25 years, I
still suck at it. Everybody I've ever worked with has sucked at it. Everybody
I've ever even heard of has sucked at it. Maybe I've had a two-and-a-half
decade of bad luck, but in 25 years I've encountered exactly two types of
people: people who insist that "estimating is a skill and you have to develop
your skill" but don't actually practice estimation,


it misses the mark a bit on pairing. Having somebody shoulder-surf
once in a while is not a bad idea, but it's definitely not pairing. Even if
you're only doing it a little, I think it's worth setting up for true pairing,
so that both people can easily jump in and work on the code as they're working
together. Even as little as adding a second keyboard and mouse can make a big
difference. People are just more engaged if they're participating.

~~~
brightball
I'm not against pairing more but there are some people who are incredibly
uncomfortable with it.

For a short period of time, you don't need much more than a person having a
suggestion and dictating if they want to jump in.

I'd have serious reservations about mandating too much of it.

There's a gap between, "I needdown to the size where
you can complete about 1 per day will go a long way towards making your
management happy. Of course the downside is that you have to be organised --
which, very ironically, most (project) managers really hate. They'd rather
have stories that say "Deliver the product" with no other details and go back
to their meeting (where they will undoubtedly discover new extremes of
productivity, finding endless stacks of 3 word stories).

~~~
borplk
Way too optimistic.

Businesses instantly turn the methodology into a device for exerting power.

What you are describing only exists in books and on manifestos and perhaps in
5% of the businesses.

The rest bastardise and devour the methodology to their liking.

------
shock
> No matter your background, you get into an organization with a label of your
> job title and you become only


specific end result) but constant,
ongoing product development. He describes a development management job (might
also be called team lead), not a PM job.

His conclusion seems right to me, though. Team management doesn't need fancy
processes. The overview of activity and backlog needs to be there and the
manager has the responsibility to enable syncing between activities and to the
outside world.

If one calms down after that conclusion, one realizes that managing a single
team of developers is trivial. Maybe that's why people are not talking about
it so much (in contrast to "nobody gets it")?

The art is in reprioritizing existing tasks when new ones come in (because
usually something needs to get dropped), and additionally there's art in
handling the meta level when single processors of a team are not just people
but subteams.

~~~
brightball
I can respect yourorganic compounds such as nutrients, micronutrients and hormones are transported into the brain by specific solute carriers. Other bioactive metabolites, lipophilic toxic xenobiotics or pharmacological agents are restrained from accumulating in the brain by several ATP-binding cassette efflux transporters, multispecific solute carriers, and detoxifying enzymes. These various molecular effectors differently distribute between the two barriers. Receptor-mediated endocytotic and transcytotic mechanisms are active in the barriers. They enable brain penetration of selected polypeptides and proteins, or inversely macromolecule efflux as it is the case for immnoglobulins G. An additional mechanism specific to the BCSFB mediates the transport of selected plasma proteins from blood into CSF in the developing brain. All these mechanisms could be explored and manipulated to improve macromolecule delivery to the brain.


entitled to vote over whether to endorse the BID proposal.

Ahead of the pre-ballot papers being sent out by Camden at the beginning of June to the 232 business rate payers, it appears The Fitzrovia Partnership suddenly became very popular. Or so it seems.

Popular in Tbilisi? A sudden increase in “likes” then they all disappeared.

During the period from 29 to 30 May 2012 an additional 1,300 “likes” were given mostly coming from the Georgian capital of Tbilisi. Fitzrovia News discovered the unusual provenance of the “likes” after examining the public analytics of the page during early June. See screen shot above.

We queried this with The Fitzrovia Partnership who responded by saying that it was unimportant but that their “techie” people would look into it. We were unaware that managingat your laptop) arrive in the second half. The Saviors continue to make their unpleasant presence known, and it looks as if we’ll be meeting more of them who aren’t particularly fond of their murderous leader. We also get to lay our eyes on a much more popular figure from the comics, King Ezekiel, the leader of a self-sustaining community known as the Kingdom.

Yes, that’s his pet tiger.

ORIGINAL:

Ahead of its panel at this year’s San Diego Comic Con, The Walking Dead has dropped a brief season 7 teaser to Twitter. Don’t worry there’s no spoilers to be found in this 30-second clip. Check it out below:

Negan’s cowering victims, choice music cues, and more lens flare than all of JJ Abrams’ movies put together make this one hell of


A 3-year Health Care Coalition Experience in Advancing Hospital Evacuation Preparedness.
This report outlines a 3-year health care coalition effort to advance and test community capacity for a large-scale hospital evacuation. The multi-year effort utilized a variety workshops, seminars, webinars, tabletops, functional exercises, and culminated with a full-scale exercise testing hospital evacuation. While most hospital evacuation exercises focus on internal movement of patients, this exercise process tested command-level decision making and it tested external partners such as transportation agencies, law enforcement, receiving hospitals, and local emergency management. This process delivered key coalition-building activities and offered a variety of training and exercise opportunities to assist a number of organizations, all at different stages of hospital evacuation planning. The 2012 Hospital Preparedness Program outlined the incorporation of health care coalition activities-103. Let b = k + -37. Are b and 8 unequal?
True
Suppose x + 10 + 2 = 0. Let i be x/6*(7/6)/(-1). Which is bigger: i or 1?
i
Suppose 0 = -i + 2*w + 10, w + 4*w = -3*i - 25. Which is smaller: i or 37?
i
Let i be -11 + 5 - (0 - -3). Let x be (-131)/(-26) - (-4 - i). Which is smaller: x or 1?
x
Let s = 1464/7 - 876950/4193. Let k(a) = -a - 11. Let n be k(-10). Which is greater: s or n?
s
Suppose -3*y + 8 = j, -j = -2*y - 2*y - 1. Is y not equal to 2/113?
True
Suppose -2*z - 9 = -5*z. Suppose -9*q = -12*q + z. Let x be 3/(q/(8/4)). Which is


a campaign against
corruption following a party conclave in November that saw Xi
Jinping succeed Hu Jintao as Communist Party General Secretary.
In November, both Hu and Xi warned that corruption threatened
the party’s hold on power.Q:

BASH, Merge two files, lower and upper triangular matrix, into one file

First file, file_utm:
1.3 3.5 2.8
    2.1 1.4
        0.5

Second file, file_ltm:
1.3
3.5 2.1
2.8 1.4 0.5

And one condition, when if i=j; then i=j=0; fi
Output file:
0 1.3 3.5 2.8
1.3 0 2.1 1.4
3.5 2.1 0 0.5
2.8 1.4 0.5 0

This is what I have tried:
#!/bin/bash
for (( x=1; x<=3; x++ ))
do
    awk -v var=$x 'NR==var' file_utm > ROW
    awk -v var=$x 'NR==var' file_ltm > COLUMN
    for (( y=1; y<=3; y++ ))
    do
        R=`awk -F  "\t" -v var=$y '{print $var}' ROW`
        C=`awk -F  "\t" -v var=$y '{print


his Spider Collector’s Journal as well.

Here’s what Mr. Crawford says about musical spiders in a Q&A via email:

Here’s Why: I really have seen house spiders bouncing (as if doing pushups) on my walls when I’ve played classical guitar music (particularly J.S. Bach) on my stereo. Am I imagining this, or are they actually enjoying it?

Rod Crawford: “Enjoy” wouldn’t be the right word, since they don’t actually have enough brain cells to feel human-like emotions. But if your stereo has enough of a woofer to send vibrations through the floor and walls, spiders would certainly feel that and react in their automatic, robot-like fashion. If any of the tones mimic the pitch of a fly’s wing vibrations, some spiders could detect that through the air as well.

HW: Would certainthat stridulate have a file on one body part and a scraper on another. The Linyphiidae (sheetweb weavers and microspiders, maybe 35% of the entire U.S. spider species list) have a file on the sides of the chelicerae (jaws) and a scraper at the base of the pedipalps. Some also have a separate apparatus with a file on the book lung covers (underside of abdomen) and a scraper at the base of the 4th legs. Spiders in various families have a file on the back end of the carapace and a scraper on the front end of the abdomen.

There are other possible variants that are less common. Even images of spider stridulatory files are scarce online, but I found one: http://jeb.biologists.org/cgi/content-nw/full/209/6/1074/FIG6

************

So isn’t this fascinating? Now we know that


play the exclusive 2 player mode. I am in the same boat as you as I have no friends that would want to play this game.

Thank you both.

let just hope that we can play it when NDS gose online instead of Nintendo releaseing another new version that the same game but with online mode.

Quote:

Personally, I'd be more interested in how that new Kirby game turns out. It certainly looks nice.

well you will find out in June.

Quote:

What's wrong with you? Kirby is one of the most awesomest characters ever created, not to mention it has one of the greatest villains of all time!

I would like to say that I doubt any one here own it or like it, because it sound to me that I am the only fancan choose between 5 battle chips you can either choose a chip or choose add, but you will not use any battle chip in that turn, you have to wait until the next turn, you can use two or more battle chips either by choosing the same type of battle chips or by codes, because every battle chip have a code, there is S and Z and Y and C etc you can choose the battle chip of the same code, for an example you have Hi cannon H and Wide Sword H and Guard S and Guard Z and Guard H in that case you can either choose Guard S and Guard Z and Guard H or Hi cannon H and Wide Sword H or Guard H,


so you have the choice either by the same kind of battle chip or the same kind of codes. You can get battle chips by defeating boss or enemies with a high busting level (just kill them fast and with out getting hit etc) you can also get some by trading with your family or by simply buy them in shops. You can get all kind of battle chips by using the Chip Trader Special, but you have to throw 3 or 10 battle chips to get one, the more you throw the more likely you will get a rear battle chips, but be careful, because if you used it in that machine, you will never get it back and you may get a bad battle chip, soone, which means it is not much of problem if you only played the first one, the story is good and all, but nothing special, the thing that I love the most is the boss battles not only they are fun and challenging, but they are also from the original Megaman, but Capcom remodel them and improved there look, which is why I love the game, because I just love surprises and this game is full with it (don?t worry, the maker of the original Megaman series is the same one that makes the Battle network series :cool guy: )

The worst part about this game is that, it has no life.
the only thing that moves are humans and if this is not bad enough then with also bad


Q:

Pandas parse date and set index- weird behavior

I am experiencing some odd behavior when I try to both parse a date column and set that column as the index while reading from a CSV with pandas.
The csv file has both a throw-away header and a throw-away index column like below (by throw-away I mean I don't want to use them)
"","X.m..d..y","fizzBuzz"
"1","2/2/1984",0.02523659
"2","2/3/1984",-0.03692308
"3","2/6/1984",-0.01597444
"4","2/7/1984",-0.006493506
"5","2/8/1984",-0.0130719

Now, I can easily read the df and then set the index afterwards with the following snippet
import pandas as pd
df = pd.read_csv('stackOverflow.csv',header=0,
                   names=['_throAwayindex','date','value'], usecols=['date','value'],
                  parse_dates=['date'] )
df = df.set_index('date')
df

Which perfectly outputs the desired result
 to improve over-the-year comparisons. Specifically, these adjustments account for administrative (noneconomic) changes such as a correction to a previously reported location or industry classification. Adjusting for these administrative changes allows users to more accurately assess changes of an economic nature (such as a firm moving from one county to another or changing its primary economic activity) over a 12-month period. Currently, adjusted data are available only from BLS press releases.

Information in this release will be made available to sensory impaired individuals upon request. Voice phone: (202) 691-5200; Federal Relay Service: (800) 877-8339.

Footnotes:(1) Average weekly wages were calculated using unrounded data.(2) Percent changes were computed from quarterly employment and pay data adjusted for noneconomic county reclassifications.(3) Ranking does not include data for Puerto Rico or the Virgin Islands.(4) Totals


Bolland And Hawks Team Up With Dominick's For Annual Book Drive

Event Information: Blackhawks center Dave Bolland will make a special appearance to sign autographs at Dominick’s as part of the Chicago Blackhawks Charities’ Second Annual Book Drive to benefit Chicago Public Schools. Fans that donate a new or gently used book at the appearance to help promote the book drive will receive an autograph from Bolland, who has posted three points (G, 2A) in six games this season. The book drive takes place at participating Dominick’s during the month of October.

Bolland, 23, has registered 67 points (24G, 43A) and 84 penalty minutes in 127 career regular-season tilts over parts of four seasons (2006-09) with the Blackhawks. Last season, the Mimico, Ontario, native appeared in 81 of Chicago’s 82When 'Doctor Who' met Santa

By Henry Hanks, CNN

updated 11:13 AM EST, Fri December 26, 2014

On November 23, 1963, "Doctor Who" was first broadcast on the BBC. Today, it remains a cult favorite among science-fiction fans young and old. Peter Capaldi (pictured with Jenna Coleman) took over as the Twelfth Doctor this season. Click through the gallery to see the men who have played the title character.

The Doctor -- a Time Lord from the planet Gallifrey who traveled through space and time -- was first played by William Hartnell, who took along his granddaughter on his adventures.

Patrick Troughton took over the role in 1966, and it was explained on the show that Time Lords can regenerate into new bodies upon their death. Troughton's Second Doctor was more of an


LONDON, June 3, 2014 /PRNewswire/ -- Lockton announced today that it has acquired the specialist motorsport insurance broker, MIS Motorsport, based in Guiseley, near Leeds. Lockton and MIS Motorsport completed the transaction on 1 June 2014 after receiving regulatory approval.

Lockton already has a presence in the UK motorsport market and in the US where it acts for a number of speedway tracks, rallies, and car clubs. MIS Motorsport is a market leader in the UK, Europe, and the Far East where it is a recognised brand across every market segment from Formula 1 to Karting, and the World Rally Championship through to Club Rallies. The acquisition will strengthen Lockton's offering in this sector and give it a winning position in the motorsport business while supporting MIS Motorsport's expansionpounds for Oxford University. She’s supported galleries and museums, built the renowned Southbank Centre for arts, and in 2013 established JW3, a non-denominational Jewish cultural center in north London.

Open gallery view Dame Vivien Duffield Credit: Maria Spann

In Israel, too, the list of recipients is long and dizzying. It includes the Weizmann Institute, to which she’s given “many millions,” in her words, and the Tower of David Museum in Jerusalem, which the Clore Israel Foundation and Duffield established.

Her family established Jerusalem’s Beit Hahayal hostel for soldiers, as well as a string of other structures and institutions in the capital, including libraries, parks, battered women’s shelters, and homes for such organizations as Ilan, for physically handicapped children, and Akim, for the mentally disabled. She has provided funds to establish and


never to tell anyone she’s divergent. The next day Beatrice and her brother Caleb must choose their factions. The whole family expects Caleb will choose Abnegation, he suits it so well, but with Beatrice they are less sure. They can choose, Abnegation: Selflessness, Dauntless: Bravery, Candor: Honesty, Erudite: Knowledge, or Amity: Kindness. When the time comes Caleb goes forward, and to everyone’s shock, transfers to Erudite: Knowledge. Beatrice tries to convince herself to stay for her parents’ sake, but in the end, transfers to Dauntless: Bravery.
The initiation process for Beatrice is hard. She shortens her name, to Tris and, with the other fourteen initiates, some Dauntless-born, some not, she begins to fight for one of the ten spots open. If she is not in the top ten, sheunderlying, throughout the series as Katniss gets to know herself. When we get back to district 12 after the first Games, Katniss begins to feel the need to protect her family and those she loves again when President Snow threatens them however as we go through the second Games (Quarter Quell) starting with Cinna gets beaten unconscious in front of her right before she enters the games until her rescue to 12, we can see that she’s slowly breaking down. Katniss is much more panicky and paranoid than usual and once she’s “safe” in 13 and she finds out Peeta’s not there, she looses it, she has a mental breakdown. Once Peeta is rescued Katniss is thrilled, everything will be fine now! On her reunion with him though,


care of people one on one, she’s more personable. Katniss protects people and goes off and fights for them, not really with them more than she can help. When Peeta is rescued and reutrns hijacked, it was Prim who thought of the reverse hijacking technique. It was she who thought of the plan that ended up saving Peeta, they boy who Katniss ends up marrying. When Prim is **SPOILER! MAJOR SPOILER** killed in the trap, it was because of her compassion and her need to help others; she couldn’t see others suffer and do nothing. We see Prim grow from being a quiet little girl who needs her big sister to protect her, to someone who will put herself into danger in order to help keep someone alive.

This– no matter what the personal cost.“

All in all, 9 out of 10. A very good book. I liked The Hunger Games better, but this one was very, very good.

And now, just for fun! This is a Hunger Games parody version of I Wanna Go by Britany Spears. It well made and hilarious! (Warning to diehard Hunger Games fans, it’s meant to be a joke, not taken seriously!)

If you haven’t read The Hunger Games by Suzanne Collins, then please note that Catching Fire is the second book in that series and this review will be littered with The Hunger Games Spoilers. Please don’t read this unless you’ve read the first book, trust me, you won’t regret it!

This is a good book, although the beginning, the Victory tour, didn’t


in each district) and manages to stay drunk until Peeta and Katniss take a stand against it. As their “mentor” he’s a big factor in how things go for them in the arena. He arranges sponsors to send them gifts during the games (food, or medicine, something they might be needing) and he decides when the things get sent. When he sees them take a stand against his drinking I think it wakes something up in him. He realizes they haven’t given up on themselves and that they want a running chance in this so he agrees to stay sober (enough) to be of help to them and in all fairness, he ends up being a great help to them. Katniss and Haymitch don’t openly get along, butturns out then to be an interesting case of the dynamics of time, its explanation involving the interplay between the two times $\tau$ and $t$. The view presented here is the relativistic version of a previous Newtonian model.
author:
- |
    Antonio F. Rañada\
    Facultad de Física, Universidad Complutense,\
    E-28040 Madrid, Spain
date: 1 July 2004
title: The Pioneer anomaly as an effect of the dynamics of time
---

PACS numbers: 04.80.Cc, 95.10.Eg, 95.55.Pe

Key words: Pioneer acceleration, Light speed, Dynamics of time.

[**Contents**]{}

1\. Introduction

1.1 The observation

1.2 The purpose of this paper

1.3 The dynamics of time and the two definitions of light speed

1.4 Constant of light speed and observed light speed

1.5 Equal fingerprints of two different phenomena

1.6 Plan of the paper

2\. On the speed of light and


also that eq. (\[2.10\]) is a first order approximation (although he does not tell which one, it is obvious that he refers to situations near the Newtonian limit). It can be written a bit more explicitly as $$c({\bf r},t ) =c_0\left\{1+\Phi ({\bf r}, t)/c^2({\bf r},t)-\Phi
_{\rm R}/ c_0^2\right\}\, , \label{2.20}$$ where $\Phi _{\rm R}$ is a reference potential, at present time in a terrestrial laboratory $R$, where the observed light speed is $c_0$, [*i. e.*]{} the constant that appears in the tables. It follows from equations (\[2.10\])-(\[2.20\]) that $c={\rm d}\ell
/{\rm d}t$ must depend on ${\bf r}$ and $t$, so that the deeper (more negative) is the potential, the smaller is the light speed with respect to $t$ and conversely (according to this Einstein formula, the light speed at the@Rin01] $${\rm d} s^2= e^{2\Phi _{\rm loc}({\bf
r},t)/c^2}\,c^{*\, 2}\,{\rm d} t^2-{\rm d} \ell^2\approx (1+2\Phi
_{\rm loc} /c^2)\,c^{*\,2}\,{\rm d}t^2-{\rm d}\ell ^2\,
,\label{3.10}$$ from which $$c({\bf
r},t)=c^*[1+\Phi _{\rm loc}/c^2]\, ,\label{3.10.1}$$ at first order (compare with (\[201\]), $\Phi _{\rm loc}({\bf
r})$ being here the (weak) gravitational potential of nearby bodies, those that produce a non negligible acceleration $g({\bf
r})$ at the observation point (the Solar System and the Galaxy, for observers near Earth). One has thus for the light speed at a generic point $P$ along a ray, $ c(P)=c(R)[1+(\Phi _{\rm
loc}(P)-\Phi _{\rm loc}(R))/c^2],$ $R$ being a reference point.

Note that (\[3.10.1\]) is the same as Einstein formula. It implies that the difference between the non-proper light speed and the $\tau$-light speed is an effect of the gravitational potential since they are equal if $\Phi =0$. The local variations


introduction of the factor $e^{-\Psi (t_0)}$ makes sure that the atomic clocks which are used tick at time $t_0$ at the same rate (if more exactly) as the mechanical classical clocks that measure parametric time $t$. This explains why a measure with the clocks with time $\tau _{\rm at}(t;t_0)$ gives the value $c(t_0)$, not $c^*$. Since they are made to tick at the same rate as the coordinate time (as the barycenter dynamic time of the solar system, for instance) they give the same value for shorts time intervals near $t_0$. On the other hand a true measurement with atomic clocks would employ clocks that ticked at the same rate as the mechanical clocks at some initial time in the past without redefining their intervals, so that theirin the Solar System is the barycenter dynamical time, which is originally a Newtonian parametric time, even if it is measured with atomic clocks in order to increase the precision. The blueshift can indeed be measured, as was the case, by using detectors with circuits calibrated in a macroscopic way. This is an indication in favor of this work. In any case, there is an interesting metrological problem.

To summarize: the conclusion of this paper is that the anomalous acceleration of the Pioneer 10/11 and the other two spacecrafts could be only apparent, not real, just an effect of the dynamics of time ([*i. e.*]{} the relation between he cosmological proper time and the coordinate parametric time) that shows up in the acceleration of light, if defined as the


information on microwaves and to G. Álvarez Galindo, C. Aroca, A. I. Gómez de Castro, E. López and J. L. Rosales for discussions or encouragement.

[16]{}

J. D. Anderson, Ph. A. Laing, E. L. Lau, A. S. Liu, M. Martin Nieto and S. G. Turyshev, Phys. Rev. Lett. [**81**]{}, 2858 (1998).

J. D. Anderson, Ph. A. Laing, E. L. Lau, A. S. Liu, M. Martin Nieto and S. G. Turyshev, Phys. Rev. D [**65**]{}, 082004 (2002) .

J. D. Anderson, E. L. Lau, S. G. Turyshev, Ph. A. Laing and M. Martin Nieto, Mod. Phys. Lett. A [**17**]{}, 875 (2002).

J. P. Mbelek and M. Michalski, Int. J. Mod. Phys. D [**13**]{}, 865 (2004).

A. F. Rañada, astro-phys/0202224, Europhys. Lett. [**61**]{}, 174 (2003).

A. F. Rañada, gr-qc/0211052, Europhys. Lett. [**63**]{}, 653 (2003)

A. F. Rañada, Intdirect AMPK activation with practically all the transcripts regulated in the same direction as reflected in the heat map in [Fig 3D](#pone.0211568.g003){ref-type="fig"} (with the corresponding scatter plot in [S3 Fig](#pone.0211568.s003){ref-type="supplementary-material"}) for the intersection signature for vastus lateralis. Additional exercise-regulated genes showed a trend toward similar regulation following direct AMPK activation however (data not shown). As described further below, there were also probesets that were specifically regulated by only one treatment, either exercise or direct AMPK activation ([S4](#pone.0211568.s004){ref-type="supplementary-material"}--[S21](#pone.0211568.s021){ref-type="supplementary-material"} Figs and [S4](#pone.0211568.s034){ref-type="supplementary-material"}--[S23](#pone.0211568.s053){ref-type="supplementary-material"} Tables), which could represent respectively, AMPK-independent effects of exercise and exercise-independent effects of pharmacological AMPK activation.

A considerable proportion of specific transcriptome responses regulated by exercise had the characteristic of being organ-specific rather than universal across all five tissues. Similarly, a considerable proportion of transcriptomic responses regulated by pharmacological


\*\*\* p \< 0.001 relative to vehicle.](pone.0211568.g005){#pone.0211568.g005}

To further investigate the potential disease modifying effects of chronic administration of a short-acting AMPK activator, three additional insulin resistant models were examined; including diet induced obese (DIO) mice, ob/ob mice and female Zucker diabetic fatty (fZDF) rats. DIO mice do not manifest fasting hyperglycemia but have elevated insulin, and after treatment with SA2 (3 mg/kg) for 4 weeks, when measured 18h post dose, there was a significant reduction in plasma insulin and a trend towards decreased fasting plasma glucose ([Fig 5F](#pone.0211568.g005){ref-type="fig"}). Daily administration of SA2 for only 7 days to ob/ob mice resulted in a progressive decrease in non-fasting blood glucose levels ([Fig 5G](#pone.0211568.g005){ref-type="fig"}). In this study, blood glucose was measured at 24h post dose, when drug level was extremely low.predominately carbohydrate oxidation with a resumption of feeding during the dark cycle ([S2A Fig](#pone.0211568.s002){ref-type="supplementary-material"}). In an extension of this study, continuing 30 mg/kg/day LA1 at thermoneutrality (housing temperature of 30--32°C as compared to standard sub-thermoneutral temperature of 22--26°C), a more pervasive shift to increased FAO was observed. Consistent with previous results with LA1 \[[@pone.0211568.ref015]\], there was no change in body weight during the study with SA1 or LA1, nor an influence of SA1 on food intake relative to control ([S2B Fig](#pone.0211568.s002){ref-type="supplementary-material"}).

Discussion {#sec009}
==========

AMPK is one of the crucial cellular signaling nodes activated in response to bio-energetic demand \[[@pone.0211568.ref035]\] and it is activated during physical activity, particularly moderate and higher intensity exercise \[[@pone.0211568.ref002]\]. It has further been postulated that activation of AMPK is a key cellular mechanism by which physical


2.0 fold). The 30 probesets shown here are listed in [S14 Table](#pone.0211568.s044){ref-type="supplementary-material"}.

(PDF)

######

Click here for additional data file.

###### Acute pharmacological AMPK activation-specific transcriptional effects in heart.

Shown in the heat map are the 61 probesets that were significantly regulated by LA2 (+/- 1.5 fold change and FDR_BH p\<0.1) and SA2 (+/- 1.2 fold change and FDR_BH p\<0.1) (red arrows), and not significantly changed by acute exercise (\< +/- 1.2 fold change and FDR_BH p\>0.2; black arrow). The color gradient represents fold change compared to vehicle treated sedentary mice (-2.0 to 2.0 fold). The 61 probesets shown here are listed in [S15 Table](#pone.0211568.s045){ref-type="supplementary-material"}.

(PDF)

######

Click here for additional data file.

###### Acute pharmacological LA2-specific transcriptional effects in heart.

Shown in the heat map are the 175 probesets that were significantly regulated by LA21.5 fold change and FDR_BH p\<0.1) and SA2 (+/- 1.2 fold change and FDR_BH p\<0.1) (red arrows), and not significantly changed by acute exercise (\< +/- 1.2 fold change and FDR_BH p\>0.2; black arrow). The color gradient represents fold change compared to vehicle treated sedentary mice (-2.0 to 2.0 fold). The 13 probesets shown here are listed in [S22 Table](#pone.0211568.s052){ref-type="supplementary-material"}.

(PDF)

######

Click here for additional data file.

###### Acute pharmacological LA2-specific transcriptional effects in liver.

Shown in the heat map are the 243 probesets that were significantly regulated by LA2 (+/- 1.5 fold change and FDR_BH p\<0.1; red arrow) and not significantly changed by either SA2 or by acute exercise (\< +/- 1.2 fold change and FDR_BH p\>0.2) (black arrows).The color gradient represents fold change compared to vehicle treated sedentary mice


significantly regulated (+/- 1.2 fold change with FDR_BH \<0.1) by both acute exercise and acute pharmacological AMPK activation (LA2, high dose) in all 5 tissues profiled.

Shown in the box plot are the log2 Intensity values per treatment group.

(PDF)

######

Click here for additional data file.

###### Cdkn1a was one of six genes (represented by 7 probesets) that were significantly regulated (+/- 1.2 fold change with FDR_BH \<0.1) by both acute exercise and acute pharmacological AMPK activation (LA2, high dose) in all 5 tissues profiled.

Shown in the box plot are the log2 Intensity values per treatment group.

(PDF)

######

Click here for additional data file.

###### Regulation of genes involved in glycogen, glucose, and lipid metabolism specifically by LA1.

Shown in the box plots are the log2_Intensity values per treatment group for genes involved inacute LA2 treatment in heart (at least 1.2-fold change and FDR_BH \<0.1). See corresponding heat map in [Fig 3D](#pone.0211568.g003){ref-type="fig"} and scatter plot in [S11 Fig](#pone.0211568.s011){ref-type="supplementary-material"}.

(XLSX)

######

Click here for additional data file.

###### Heart exercise-specific signature.

30 probesets robustly regulated only by acute exercise, and not by acute AMPK activator treatment, in heart (at least 1.5-fold change and FDR_BH \<0.1). See corresponding heat map in [S12 Fig](#pone.0211568.s012){ref-type="supplementary-material"}.

(XLSX)

######

Click here for additional data file.

###### Heart AMPK activator-specific signature.

61 probesets significantly regulated only after acute AMPK activator treatment (at least 1.5-fold change and FDR_BH \<0.1 by LA2, and at least 1.2 fold change and FDR_BH p\<0.1 by SA2), and not by acute exercise, in heart. See corresponding heat map in [S13 Fig](#pone.0211568.s013){ref-type="supplementary-material"}.

(XLSX)

######

Click here for additional data file.

###### Heart LA2-specific signature.

175 probesets significantly


in [S19 Fig](#pone.0211568.s019){ref-type="supplementary-material"}.

(XLSX)

######

Click here for additional data file.

###### Liver AMPK activator-specific signature.

13 probesets significantly regulated only after acute AMPK activator treatment (at least 1.5-fold change and FDR_BH \<0.1 by LA2, and at least 1.2 fold change and FDR_BH p\<0.1 by SA2), and not by acute exercise, in liver. See corresponding heat map in [S20 Fig](#pone.0211568.s020){ref-type="supplementary-material"}.

(XLSX)

######

Click here for additional data file.

###### Vastus muscle LA2-specific signature.

243 probesets significantly regulated only after acute LA2 treatment (at least 1.5-fold change and FDR_BH \<0.1 by LA2, and not significantly changed by either SA2 or by acute exercise (\< +/- 1.2 fold change and FDR_BH p\>0.2) in liver. See corresponding heat map in [S21 Fig](#pone.0211568.s021){ref-type="supplementary-material"}.

(XLSX)

######

Click here for additional data file.

###### Regulation of genes in glycogen, glucose and fatty acid metabolism pathways.

(XLSX)

######of the award were Nebraska-Kearney heavyweight Tervel Dlagnev (2008), Nebraska-Omaha 157-pounder Todd Meneely (2009), Pittsburgh-Johnstown 133-pounder Shane Valko (2010), Western State 197-pounder Donovan McMahill (2011), Upper Iowa 133-pounder Trevor Franklin (2012) and Grand Canyon heavyweight Tyrell Fortune (2013).


By Justin Gardner

Before the War on Drugs cast its shadow across humanity, a collective mind expansion was being achieved in part thanks cannabis and psychedelics. For decades the military-corporatist state has suppressed the human right to ingest “illicit” substances – while profiting from this prohibition – but the pursuit of knowledge has a way of thriving despite fascism.

While research on the medicinal uses of cannabis has increased at a tremendous pace, therapeutic research into psychedelics has also garnered more interest in recent years. In 2014, advanced cancer patients “experienced immediate and dramatic reductions in anxiety and depression, improvements that were sustained for at least six months” with a single dose of psilocybin (the “magic mushroom” active ingredient).

Psilocybin is successfully treating patients with attention deficit hyperactivity disorder (ADHD) andthe satisfaction of having built it yourself. Congratulations sir, you are a grease monkey superhero.

A little history on the car. 100% hand crafted Countach out of aluminum and a space tube frame. All aluminum body formed on a wooden buck using an English wheel. My own design space frame with Corvette hubs and custom A-arms. Mated to a ZF-25 5 speed. S.S. 180 degree headers GT40 design "bundle of snakes" Boss 351 bored stroked to 377 515hp 48 IDA Webbers. One off TransAm BBS rim shells to my own center section wheels. Custom brake package to fit 16" wheels. Fuel cell, twin aluminum sprint car (Howe) radiators. All aluminum interior with leather dash, Momo seats and 5 point harness, on board halon fire bottle. quick release steering wheel.


could be mounted on the concrete blocks and so that the block tongs could be removed from the concrete blocks once the blocks were properly positioned adjacent the job site.
A multi-unit concrete block tong assembly is provided which includes three top tubes pivotally connected at one end thereof to one end of three bottom tubes. A lifting apparatus is operatively connected to the three top tubes whereupon upward movement of the three top tubes by the lifting device will cause the top tubes to pivot with respect to the bottom tubes. A front plate is secured to one end of each of the top tubes for movement therewith. A back plate is longitudinally adjustably secured to each of the bottom tubes adjacent the other end thereof. A solenoidbowl, agar will ultimately liquefy. You can eventually, still inhale it in its liquid form, just as soon as you have one of the vortex/phunnel bows (i.e the one that prevent leakages).
You've probably seen "shisha gels"

They obviously do resemble "jelly-alike cubes", but they are actually made of something very different - hydroponic gel (also this) (water crystals) which is often used as artificial weed and is not meant for human consumption. Whether it is healthy or not per se is debatable, I wouldn't use them.
Also, there is a known shisha aroma manufactured by Changning Dekang Biotechnology Co,. Ltd that, according to its creators consists of "natural fruits", such as orange cores. It also looks like jelly.
(see random review if you like)
Vaporizing alcohol as you suggest is a terrible


Alberto were Double-A firsts for both hitters. Mazara’s blast to right field was the first of his career with Frisco and 20th of the season. Alberto went deep to left for his first jack as a RoughRider in 2014 and sixth on the year. The shortstop also hit four long balls with the ‘Riders in 2013.

-Teodoro Martinez extended his hitting streak to seven games with a single in the second. Teo is one game shy of tying his season-high of eight straight with a base knock.

-Patrick Cantwell was hit by a pitch for the 18th time this season, the most in the Texas League. He also drew a walk in the third and now has 17 base on balls in 2014.

-The ‘Riders snapped a streak of six straightof raw power at Bishop Gorman High School in Las Vegas, but there was concern his game was one-dimensional and that his height would prohibit him from playing an infield position. The Rangers weighed the risks and decided to take a chance on him with the 39th pick in the supplemental first round.

Now in his third season, Gallo has quickly gone from a well-known prospect in the Rangers organization to a name recognizable across professional baseball.

As a teenager in 2013, Gallo blasted 40 homers that season and earned the Joe Bauman Award as the top home run hitter in the minor leagues. In the process, he became the first teenager in more than 50 years to hit 40 home runs in a minor league season. The buzz around


Even Fans Admit Chances Of TPP Being Ratified By US Soon -- Or Ever -- Have Just Slumped

from the stumped-by-Trump dept

In the wake of the unexpected win of Donald Trump, people in many fields are starting to re-examine their assumptions about what might happen in the next few years. One of the areas impacted by Trump's success is trade in general, and trade deals in particular. For perhaps the first time, the 2016 election campaign put trade deals front and center. They may even have contributed to Hillary Clinton's downfall, since many found her sudden conversion to the anti-TPP movement unconvincing, to say the least.

Given Trump's vocal antipathy to TPP, even its strongest supporters are recognizing that it is now in trouble. Here, for example, is John Key,Prime Minister of New Zealand, and one of the cheerleaders for the deal: [TPP] would have been nice to have, but we're not going to have it in the short term. The leader of the main opposition party in New Zealand agreed: [TPP] seems to be dead in the water now. The Radio New Zealand report that these comments are taken from had further confirmation of TPP's demise from a source with privileged access to the man himself: A close Trump supporter, Senator Jeff Sessions, told reporters at Mr Trump's victory party last night the proposed deal was now "dead". Of course, "dead" is not an absolute term in politics. TPP may be dead in the short term -- something underlined by US Senate Majority Leader Mitch McConnell


Hypoxic injury in the proximal tubule of the isolated perfused rat kidney.
The effect of hypoxia on the morphology of the proximal tubule was examined in isolated rat kidneys perfused with Krebs-albumin medium, gassed with 95% N2/5% CO2 for 45, 90 and 190 min. The major findings were heterogeneity of types of cell injury and definable topographical zones of protection from damage. The characteristic injury in S1 and S2 was that of mitochondrial swelling and brush border alterations that progressed to complete disorganization of this zone. S3 manifested two distinct lesions, one characterized by cell swelling and the other by tubular epithelial fragmentation. Protection from these injuries was seen in tubules located in periarterial zones, apparently due to gradients of oxygenation. The same types of injury but without zonesyou using Access web services (that is Access web publishing for 2010), then the Access web reports render these reports near “perfect” in word and in fact Web Access Reports render better in Word then do client based Access applications!
So for example, looking at an Access Web based Report, you see this option:

If you click on actions then you get this option in the web browser:

Now, when you click on that, you can choose PDF or Word and your LOCAL client opens + renders the report. Really nice is all graphics and formatting is preserved in the web report (unlike client reports that loose their graphics).
The above of course is using Access Web publishing which just so happens to use SQL server reporting services. The “key” suggesting here


films
Category:American black-and-white films
Category:English-language films
Category:Films about journalists
Category:Films directed by Benjamin Stoloff
Category:Films scored by Adolph Deutsch
Category:Warner Bros. filmsits purpose:

"I just thought it was a statement to have something close to the state Capitol," said Dhar Mann, who founded the original iGrow in January 2010. "It's a statement of how progressive the industry has become. We're all about coming out of the shadows." With California, 14 other states and the District of Columbia legalizing marijuana for medical use, the hydroponics industry is exploding. But, unlike weGrow, most hydroponics outlets avoid any mention of marijuana, billing themselves only as generic suppliers for people growing anything from peppers to rosemary.

weGrow's unearthing has led CBS news to ask an essential question: Is medical marijuana going mainstream?


allograft dysfunction and the development of biliary complications---not captured by the Eurotransplant Registry---would be very valuable. In addition, now that the detrimental effect of longer implantation time has been demonstrated, additional confounding factors, such as surgical technique (piggyback vs caval replacement; reperfusion of the artery before portal vein, use of a cold rinse during implantation), the number and nature of the arterial reconstruction, the presence of portal vein thrombosis, and so on, that are not detailed in the Eurotransplant registry need to be teased out in other data sets that do contain this information.

In conclusion, implantation time is a risk factor for liver transplant outcome, especially in the first months after transplantation. This finding identifies the need for better understanding of confounding factors as well as the needto limit perioperative warm ischemic injury to improve outcome after liver transplantation. Validation of these findings and exploration of uncaptured confounders in other large data sets are needed.

Supplementary Material
======================

###### SUPPLEMENTARY MATERIAL

The authors thank all centers within the Eurotransplant for providing the data and Erwin de Vries from Eurotransplant for compilation of the data. The authors also thank the Eurotransplant Liver and Intestinal Advisory Committee and the Eurotransplant Organ Procurement Committee for their support.

Published online 18 May, 2018.

I.J. and J.P. are holders of a named chair at the KU Leuven of the Centrale Afdeling Voor Fractionering (CAF). J.P. holds a named chair at the KU Leuven of the Institute Georges Lopez (IGL).

There was no funding for this study.

I.J. designed the study, performed the research, interpreted the data, and wrote


about money.

I frankly don't find Apple or Samsung or any of the others for that matter, have a monopoly on being the good guys.

Components in devices I buy like the iPhone yes I can't help that . But their product line I do not purchase any more !Edited by comley - 4/27/14 at 4:53am

The term "server" is pretty generic. Technically speaking, a single App that has one thread dedicated to "serving" requests made by other threads in the same App could be a server. Or a process running in iOS that serves requests by multiple Apps is also a server. Or the term most people think of - a separate physical machine somewhere on the Internet that serves numerous applications on numerous machines.

The core concept to me ispatent was applied for over 15 years ago in 1996 I believe the intent was that a separate and distinct "server" would be involved. I think you do too. That the claim construction today could be broadly read and extend to technology the original inventor did not anticipate doesn't make it correct. In any event whatever anyone here believes could possibly be construed as an "analyzer server" doesn't matter. A court will determine what the intent would have been since apparently no one else can agree on it.Edited by Gatorguy - 4/28/14 at 6:08am

When the patent was applied for over 15 years ago in 1996 I believe the intent was that a separate and distinct "server" would be involved. I think you do too. That the claim construction


loan turnover is relatively small, were 1 thousand and 300 yuan, 1 thousand and 300 yuan and 1 thousand yuan. From the new board stock market performance, 8 stocks rose more than 100%, the style of information, network and cloud go see gainers, were up 2595%, 380.77% and 303.78%; in contrast, Doyle ites, Xinxin Long Xin and diamond game decreases, fell 90.04%, 82% and 67.06%.respective systems. It is generally known that, as stated in Japanese Laid Open Patent No. Sho 52-134452, the choice of the latter type is preferable to achieve good correction of distortion, and a minimization of the diameter of the front lens members is facilitated by employing the former type.
Examples of two-component wide angle zoom objectives are disclosed in U.S. Pat. Nos. 4,159,865 and 4,153,339.


see for the WP7 or iOS systems.

Post navigation

3 thoughts on “Qt Everywhere?”

Actually not. I think MeeGo with Qt as primary development environment gets a lot more interesting, if your Qt applications run there and on Android devices. MeeGo might be only a small market segment, but if you get your MeeGo app for free if you develop it with Qt for Android, why not provide it for MeeGo, too? Or the other way around.fine, and the DeLuca brothers will shell out a cumulative $1.1 million. Click here to learn more.

Dietary Supplement Update 4/10/12: Less than a third of active soldiers discuss dietary supplement use with their doctors prior to taking them, according to a new study about drug use by military service members. Many of these individuals don’t consider the use of supplements to affect medications. However, when taken simultaneously, prescription drugs and dietary supplements can significantly increase a person’s risk of potentially life-threatening side effects. Click here to learn more.

Free Dietary Supplement Lawsuit Evaluation: If you or a loved one has been injured by a dietary supplement, you should contact our law firm immediately. You may be entitled to compensation by filing a suit against the manufacturer of the dietary


to market as quickly and cheaply as possible.

In an effort to keep up with the ever-expanding dietary supplement trade, the FDA last July laid out a series of updated requirements aimed at determining a ‘reasonable expectation of safety’ for those marketing ‘novel’ products. In some cases, the administration would accept a company’s documentation of a supplement’s ‘historical use’ outside the US. For products marketed as mega-dose supplements, the FDA would require evidence of safety from animal and test-tube studies.

Dr. Cohen feels the FDA’s new regulations fall short, and don’t go far enough to ensure public safety. The so-called ‘historical use’ of a dietary supplement where no one is looking for harmful side effects is a dangerous standard far too simplified to assure safety, he writes. Additionally, Cohen statesthe March of Dimes to raise money for research into a cure for polio, as well as a national foundation at Warm Springs, Georgia for its treatment. FDR, himself, underwent treatment at this facility. His mother was the matriarch of the family and encouraged him, in her usual dominating manner, to retire to his home in Hyde Park and live his life contently there. Instead, he and Eleanor went against the grain. Eleanor, with the help of his trusted aide Louis McHenry Howe, assisted Franklin in keeping active in the Democratic Party. Franklin's mother was not happy at her lack of control, and she often took out her wrath on Eleanor.

At the Democratic National Convention of 1924, Franklin Roosevelt finally made a return to the political stage. He


act, the Allied countries could trade leased foreign bases for supplies and ships under a cash and carry arrangement that would have materials delivered to their ports by American ships. Soon America's factories were again humming, and war materials flowed to the Allies in huge numbers.

Many of the American people did not want to enter into another war. Like the public, Roosevelt and his staff were divided on the matter; but the less-than-neutral actions of the United States with regard to shipping made for deteriorating relations with the Axis powers. The decision to enter the war was made for the US when on December 7, 1941, the Japanese Navy bombed the American fleet at Pearl Harbor. Hitler then also declared war on the United States. This truly wasa world war to end all wars. When Roosevelt spoke of the attack in his address to Congress on December 8, 1941, he called it "A day that will live in infamy." Yet Roosevelt had been eager for the United States to enter The War on the behalf of the Allies, and some argue he welcomed the Japanese attack as the excuse he needed. Roosevelt mobilized for war by enacting Woodrow Wilson's Selective Service Act, which created a draft to secure men for armed forces, and the War Production Board, which consolidated industry for the production of war materials on a massive scale.

Roosevelt and Britain's Prime Minister, Winston Churchill, planned all aspects of the war with unity and purpose. Their first mission was to annihilate Hitler and force


/*

  Copyright (C) 2005 Silicon Graphics, Inc.  All Rights Reserved.

  This program is free software; you can redistribute it and/or modify it
  under the terms of version 2.1 of the GNU Lesser General Public License
  as published by the Free Software Foundation.

  This program is distributed in the hope that it would be useful, but
  WITHOUT ANY WARRANTY; without even the implied warranty of
  MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.

  Further, this software is distributed without any warranty that it is
  free of the rightful claim of any third person regarding infringement
  or the like.  Any license provided herein, whether implied or
  otherwise, applies only to this software file.  Patent licenses, if
  return newd;
}

/* Notify checker that get_alloc has allocated user data. */
void
dwarf_malloc_check_alloc_data(void *addr_in, unsigned char code)
{
    struct mc_data_s *newd = newone();
    unsigned long addr = (unsigned long) addr_in;
    struct mc_data_s **base = &mc_data_hash[hash_address(addr)];

    print_alloc_dealloc_detail(addr, code, "alloc   ");
    newd->mc_address = addr;
    newd->mc_alloc_code = code;
    newd->mc_type = MC_TYPE_ALLOC;
    newd->mc_alloc_number = mc_data_list_size;
    newd->mc_prev = *base;
    *base = newd;
    newd->mc_alloc_number = mc_data_list_size;
    mc_data_list_size += 1;
}

static void
print_entry(char *msg, struct mc_data_s *data)
{
    fprintf(stderr,
        "%s: 0x%08lx code %2d (%s) type %s dealloc noted %u ct %u\n",


*addr_match = 0;
    unsigned long addr = (unsigned long) addr_in;
    struct mc_data_s **base = &mc_data_hash[hash_address(addr)];

    print_alloc_dealloc_detail(addr, code, "dealloc ");
    newd->mc_address = (unsigned long) addr;
    newd->mc_alloc_code = code;
    newd->mc_type = MC_TYPE_DEALLOC;
    newd->mc_prev = *base;
    prev =
        balanced_by_alloc_p(newd, &addr_match_num, &addr_match, *base);
    if (prev < 0) {
        fprintf(stderr,
            "Unbalanced dealloc at index %ld\n", mc_data_list_size);
        print_entry("new", newd);
        fprintf(stderr, "addr-match_num? %ld\n", addr_match_num);
     attorney

Results

General election

Fundraising

Debates
 Complete video of debate, October 6, 2014

Predictions

Polling

Results

See also
 2014 United States Senate elections
 2014 United States elections
 2014 United States House of Representatives elections in Idaho
 2014 Idaho gubernatorial election

References

External links
 U.S. Senate elections in Idaho, 2014 at Ballotpedia
 Campaign contributions at OpenSecrets.org

2014
Idaho
Category:2014 Idaho elections


gland sits behind the nose and eyes.

Meningiomas. These tumors are often benign and grow from the meninges, the tissue that covers the brain and lies between the brain and skull.

Chordomas. This is a slow-growing bone tumor most often found at the base of the skull.

Trigeminal neuralgia, an intense pain on one side of the face.

Craniopharyngiomas, growths that occur near the pituitary gland.

Craniosynostosis, a condition in which the bones of the skull of an infant close too early, causing problems with brain growth and the shape of the skull.

Cerebrospinal fluid fistulas.

Cerebral aneurysm, a weak, often bulging area in a blood vessel in the brain.

Arteriovenous malformations. These are arteries and veins that are abnormally connected to one another.

Types of skull base surgery

Skull base surgery can be done in two mainthe family because it failed to take into
consideration her diagnoses of bipolar disorder and attention deficit hyperactivity disorder
(ADHD). This Court reviews the trial court’s findings of fact, including a finding that DHHS
made reasonable efforts toward reunification, for clear error. See In re Fried, 266 Mich App
535, 541; 702 NW2d 192 (2005). After reviewing the lower court record, we conclude that
respondent-mother has failed to demonstrate that the trial court clearly erred.

        Before a court may contemplate termination of a parent’s parental rights, the petitioner
must generally make reasonable efforts to reunite the family. MCL 712A.19a(2). “The
adequacy of the petitioner’s efforts to provide services may bear on whether there is sufficient
evidence to terminate a parent’s rights.” In re Rood, 483 Mich 73, 89; 763


NW2d 587 (2009).
However, a respondent also has a responsibility to participate in services offered by petitioner.
In re Frey, 297 Mich App 242, 248; 824 NW2d 569 (2012).

         Very recently, our Supreme Court, in In re Hicks/Brown Minors, __ Mich __; __ NW2d
__ (2017) (Docket No. 153786), considered whether the DHHS made reasonable efforts to
reunify an intellectually disabled parent with her children.1 The Court considered obligations
that arise under both the Americans with Disabilities Act (ADA), 42 USC 12101 et seq., and
under the Michigan Probate Code, MCL 712A.18f(3)(d). Under the Probate Code, “the
Department has an affirmative duty to make reasonable efforts to reunify a family before seeking
termination of parental rights.” Hicks/Brown, __ Mich at __; slip op at 4. The Supreme Court
alsonoted,
however, that DHHS cannot accommodate a disability of which it is unaware. Id. Applying the
foregoing principles, we conclude that the record in this case does not establish that respondent-
mother suffered from a disability for which she required accommodation, or for which she was
not already being accommodated.

      Respondent-mother contends that the DHHS failed to accommodate her bipolar disorder
and ADHD. However, there is nothing in the record to support a finding that DHHS was aware

1
  The Supreme Court indicated that there were two questions presented: “whether Brown timely
raised her claim for accommodation before the circuit court, and if so, whether the Department’s
efforts at family reunification were reasonable.” Hicks/Brown, __ Mich at __; slip op at 1.
However, it later found that it had “no occasion


in-home. The foster care
worker also made appointments to have simple telephone conversations with respondent-mother
during which they could discuss ways to improve her compliance. Respondent-mother failed to
take advantage of these opportunities. Based on the foregoing, respondent-mother has failed to
demonstrate that DHHS failed to accommodate a known disability. Accordingly, the trial court
did not err when it found that DHHS’s efforts toward family reunification were reasonable.

         For his first argument on appeal, respondent-father argues that the trial court clearly erred
when it concluded that there existed clear and convincing evidence to terminate his parental
rights. And then both respondents contend that the trial court clearly erred in finding that
termination of their parental rights was in the children’s best interests. If a trial court finds thatfollowing:

              (i) The conditions that led to the adjudication continue to exist and there is
       no reasonable likelihood that the conditions will be rectified within a reasonable
       time considering the child's age.

               (ii) Other conditions exist that cause the child to come within the court's
       jurisdiction, the parent has received recommendations to rectify those conditions,
       the conditions have not been rectified by the parent after the parent has received
       notice and


heard before. Is it pop? Is it punk? Toy electronic meets disco hardcore? Are they some sort of sci-fi post-punk preachers? Or is this the pop that will hit the punk rock billboards by the year 2010? Too many questions, but one thing for sure, its that they know how to make their audience
dance and yell without falling into or faking a trend.Whatever,dont theorize. Maniqui Lazer is here for you to have fun."
Marked by RADIANTE PRESS from Tijuana as best new
mexican band in 2005.

They call their brand of music - 'Lazer Punk'. They've only existed since December 2005, but they've already released a charm of an album and have built a substantial fanbase thoughout their native Mexico. Elements of Beat Punk, Electro-Synth and searing vocals is the reciepeover.

The same night of his death, Sanny says WenJian visited her in an incredible dream. In it, he handed her a baby girl.

“I had a dream,” she said. “He handed me the baby. He said ‘Here’s the baby. Here’s a girl.'”

Sanny knew in her heart this dream would come true.

Life Out Of Death

Sanny asked the doctors if they could preserve some of her late husband’s semen. They complied, though they had no idea if it was going to work.

Miraculously, it did!

Through the process of in-vitro fertilization, the police officer’s widow gave birth to a baby girl. Sanny named her daughter Angelina, so she could stand as an angel for all of the NYPD police officers.

“I hope she’ll bring all the hope and strength to my big blue family,”


Q:

How to AddDriver the rotation value of the armature for the rotation value of the object

I did AddDriver for RotationX of the cube.
From the EditDriver, I selected Armature in Prop.

In Path, "pose.bones [" Bone "]. Rotation_quaternion [0]" was input.
However, rotating the armature did not move the Cube.
How to AddDriver the rotation value of the armature for the rotation value of the object?
I don't want to use Child of constraints.
Because I want to use Bone's local value.

A:

In the drivers editor, variable tab, instead of "single property" use "transform channel" ( (X) Symbol), then choose your bone, choose X rotation with auto euler option, choose world or local space, and when rotating the bone in pose mode, X rotation of the cube will follow.

Q:

C# console app to send email at scheduled times

I've got a C# console app running on Windows Server 2003 whose purpose is to read a table called Notifications and a field called "NotifyDateTime" and send an email when that time is reached. I have it scheduled via Task Scheduler to run hourly, check to see if the NotifyDateTime falls within that hour, and then send the notifications.
It seems like because I have the notification date/times in the database that there should be a better way than re-running this thing every hour.
Is there a lightweight process/console app I could leave running on the server that reads in the day's notifications from the table and issues them exactly when they're due?
I thought service, but that seems overkill.

A:

My suggestion is to


    properties["quartz.threadPool.threadCount"] = "5";
        properties["quartz.threadPool.threadPriority"] = "Normal";

        var sf = new StdSchedulerFactory(properties);
        _scheduler = sf.GetScheduler();
        _scheduler.Start();
    }

    public static ScheduleManager Instance
    {
        get { return _instance; }
    }

    public void Schedule(IJobDetail job, ITrigger trigger)
    {
        _scheduler.ScheduleJob(job, trigger);
    }

    public void Unschedule(TriggerKey key)
    {
        _scheduler.UnscheduleJob(key);
    }
}

First job,are making use of your SQL server process to send mail, which is not a good practice.
However you can invoke a web service, OR WCF service which can send emails.
But Approach 1 is error free, Scalable , Track-able, Asynchronous , and doesn't trouble your data base OR APP, you have different process to send email.
Queues
Use MSMQ which is part of windows server
You can also try https://www.rabbitmq.com/dotnet.html

A:

Pre-scheduled tasks (at undefined times) are generally a pain to handle, as opposed to scheduled tasks where Quartz.NET seems well suited.
Furthermore, another distinction is to be made between fire-and-forget for tasks that shouldn't be interrupted/change (ex. retries, notifications) and tasks that need to be actively managed (ex. campaign or communications).
For the fire-and-forget type tasks a message queue is well suited. If the destination


puncture.

Do Lawn Aerator Shoes Work?

Sandals for aeration of the lawn look more like a certain addition to the basic footwear or a separate special sole on a convenient fastening. Special sharp spikes with a certain pitch are attached to this soil.

The main task of spike shoes is to make special uniform pores in the soil, through which the nutrients are supplied to the roots of the plants.

The principle of work of aerator shoes is very simple – just put them on your basic shoes, sandals, boots, fasten the straps, and walk on the lawn. Of course, you should not walk randomly, try to tread on a certain place only once, so that the creation of holes was uniform. This is also very important for proper water and airtime, the transaction fees must rise to keep miners
interested. Based on 600,000 transactions per day in 1MB-bitcoin, that's a
$2.40 rise per transaction by time block rewards drop to zero in order to keep
miners interested. Ouch.

~~~
coralreef
Can you expand on the fossil fuels comment?

~~~
jepler
What I mean is that most electricity is presently generated from fossil fuels.
E.g., 2008 figures on wikipedia show 2/3 of electricity from coal+oil+natural
gas
[https://en.wikipedia.org/wiki/Electricity_generation#Product...](https://en.wikipedia.org/wiki/Electricity_generation#Production)


on the observer. This is because one observer might judge a face as showing genuine anger, whereas another observer might judge the same face as showing deceptive anger. However, the type of facial information that is used for interpreting another person's hidden emotions or recognizing deceptive faces is unclear.

In this study, we focused on the spatial frequency components of faces, which are important for interpreting facial expressions ([@ref40]). Low-spatial frequencies (LSFs) carry information about the configural properties of facial parts, such as the eyes, the nose, and the mouth, whereas high-spatial frequencies (HSFs) contain finer, edge-based information supporting the processing of these features, resulting in detailed image representations and object boundaries ([@ref13]). In studies examining the perception of static natural scenes, the parallel processing of LSF and HSFcomponent.

It has also been demonstrated that LSF and HSF do not equally contribute to identifying negative expressions ([@ref46]). Understanding negative emotion from facial expressions is potentially important for survival (relative to positive emotion), and this may be why the visual system is biased toward the processing of negative expressions ([@ref44]). In fact, negative expressions attract and hold attention more frequently and for longer than positive expressions ([@ref27]). Importantly, the prioritized processing of negative expressions is specifically attributed to the neural pathway tuned to LSF components ([@ref46]). Low-spatial frequency preserves coarse information associated with an object's shape and layout, which is transmitted to the cortex and subcortical structures through the rapid magnocellular pathways ([@ref4]). A functional magnetic resonance imaging (fMRI) study showed that the human amygdala, which allocates attention


value was reached and the same key was pressed, the value of the expression began to decrease. Similarly, when a minimum value was reached, the value of the expression began to increase. See [Figure 1B](#fig1){ref-type="fig"} for a schematic illustration. The assignment of the keys (i.e., left- and right-hand side of the game controller) was counterbalanced across participants. Participants were allowed to generate each face at their own pace. They pressed the decision key when they were finished, after which the next face appeared.

Results and Discussion {#sec7}
----------------------

[Figure 2](#fig2){ref-type="fig"} shows the mean expression value of the images developed for each spatial frequency in the happiness and anger blocks. In this study, although a three-way analysis of variance (ANOVA) with emotion (happiness or anger), face to-be-generated (deceptive or genuine), and spatialdata of each participant to clarify the combination of LSF and HSF expression values that were subject to be classified as each face type. If the mode was more than one (i.e., there were two or more peaks in the frequency histogram), they were averaged. We decided to use the mode rather than the mean of the classification proportion because the mean would not reflect the typical values in each category. For example, typical values of genuine anger expression should be near −10 for LSF and HSF. However, the mean values of the classification proportion increase close to zero because of the edge effect (i.e., stimuli more negative than −10 cannot be made). Therefore, the mode was considered appropriate to estimate the typical values in each category. [Figure


LSF and HSF, while deceptive anger consists of low LSF and HSF intensities. These results suggest that contribution of the LSF and HSF components are not equal when interpreting happy and angry deceptive faces.

The present study suggests that it is possible to discriminate deceptive happiness from a genuine one. This is because a deceptive happiness consists of unbalanced amounts of LSF and HSF expression, whereas a genuine happiness consists of approximately equal LSF and HSF intensities. In other words, detecting the unbalanced intensities of happiness expression between LSF and HSF allows us to be sensitive to hidden anger. Conversely, it must be difficult to distinguish between deceptive and genuine anger because both are represented by approximately equal LSF and HSF intensities. Although deceptive anger has lower intensities offor an adaptive function of quick risk aversion ([@ref44]). It is possible that the sensitivity to hidden anger in deceptive happiness found in this study is governed by the same visual pathway, although there is not yet empirical evidence for a relationship between amygdala activation and the processing of hidden anger facial expressions.

We adopted a face-generating task in Experiment 1 and a face-classification task in Experiment 2 and asked the participants to encode and decode facial expressions. Although these tasks examined different processes (i.e., encoding/decoding deceptive facial expressions), both tasks showed similar results with a trend for only deceptive happiness to show differential intensities in the expressions between LSF and HSF. These consistent results supported the notion that processing deceptive happiness depends on the balance between LSF and


spatial frequency components higher than those used in this study could contain clues to identifying negative expressions. Obviously, further studies are required to investigate whether interpreting all types of hidden negative expressions is dependent on LSF components and that higher spatial frequency components contribute to discriminating between deceptive and genuine happiness.

Another limitation of the present study using artificial face models is that perceptual sensitivity to spatial frequency may differ between artificial and real faces. It has been reported that artificial facial models could give us different impression comparing with photos of real faces, although general tendencies to evaluate face images are similar ([@ref7]; [@ref1]; [@ref2]; [@ref14]). It is also unclear whether LSF and HSF components contain different facial expression when deceptive faces are made in real situations. Althoughour data clearly demonstrate that human observers have an ability to categorize deceptive happiness of artificial face models depending on the mismatch between LSF and HSF components, it is the first step to understand how spatial frequency information is used to identify real deceptive faces.

The results of this study are based only on male participants because of limitations in the subject pool that was available to us. Several studies have suggested that women are more sensitive to emotional faces than men (e.g., [@ref17]). However, many other studies have indicated that the gender of the participants does not affect the detection of emotions in hybrid facial images composed of emotional expressions in LSF and neutral expressions in HSF. For instance, [@ref37] demonstrated that female faces tend to be evaluated


they wanted to share with their...

Romina Camiliing is a "savvy mom creating awareness for a healthy family, community, and planet" through her awesome blog Just Another Hat. She recently reviewed milkmakers on her blog. Here's an excerpt from her review:
"My first experience with breastfeeding was definitely not a positive one....

Monica at macaronikid.com, having trouble producing enough milk for her son, Ben, recently sampled milkmakers cookies to see if they could boost her milk supply. Here's an excerpt from her review.
"In an effort to boost my milk supply, I've turned to any and all remedies...

One of the things that I love about customer service calls is listening to the moms tell their stories. They are real moms, with real stories. I wish that every mom out there could hearthem first hand like I get to. Hearing the emotion in their voices when they...

Milk and Cookies (aka Lactation Cookies)
Thank you Kimberly from Zenana Spa and Wellness Center for the great review and for helping us spread the word about milkmakers to other breastfeeding moms.
Milk and Cookies (aka Lactation Cookies)
April 1st, 2011 .
by Kimberly Bepler, ICPE, IAT (ICEA), PCD (DONA), CPD (CAPPA)
Milk...

I was living in Brazil when I had my 2 daughters (now aged 6 and 7 years old). Breastfeeding support was nonexistent. I really struggled to feed my eldest daughter and spent many hours trawling the internet for advice and information. I only managed to...

When my daughter was born three years ago, I was a stressed out and busy Marketing Manager. I was committed to breastfeeding for


0.06) !important;
  border: 0 none !important;
  -webkit-box-shadow: inset 0 0 12px 4px #ffffff;
  box-shadow: inset 0 0 12px 4px #ffffff;
}
.selectize-control.plugin-drag_drop .ui-sortable-placeholder::after {
  content: '!';
  visibility: hidden;
}
.selectize-control.plugin-drag_drop .ui-sortable-helper {
  -webkit-box-shadow: 0 2px 5px rgba(0, 0, 0, 0.2);
  box-shadow: 0 2px 5px rgba(0, 0, 0, 0.2);
}
.selectize-dropdown-header {
  position: relative;
  padding: 3px 12px;
  border-bottom: 1px solid #d0d0d0;
  background: #f8f8f8;
  -webkit-border-radius: 4px 4px 0 0;
  -moz-border-radius: 4px 4px 0 0;
  border-radius: 4px 4px 0 0;
}
.selectize-dropdown-header-close {
  position: absolute;
  right: 12px;
  top: 50%;
  color: #333333;
  opacity: 0.4;
  margin-top: -12px;
  line-height: 20px;
  font-size: 20px !important;
}
.selectize-dropdown-header-close:hover {
  color: #000000;
}
.selectize-dropdown.plugin-optgroup_columns .optgroup {
  border-right: 1px solid #f2f2f2;
  border-top: 0 none;
  float:love making session without any interruption. Thus, avail the enormous fun from sexy escorts in Jaipur devoid of any waiting. http://www.poojarathore.com

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Krishna.com is a non-profit, and we rely on your donations. If everyone reading this gave $2, we’d be able to continue this mission for another year. Please donate. $21 | $11 | $5 | $2 | Donate a custom amount.

SB 1.3 - King Pṛthu and Matsya

Submitted by Radhikesh on Tue, 2011-06-21 09:31

(9) Prayed for by the sages, the Lord accepted the body of a king (Pṛthu), who cultivated the land to yield produces, and for that reason the earth was beautiful and attractive. He appeared from the right arm of King Veṇa in a golden complexion. Because he milked herbs and other things from the earth, he is considered the most desirable of the avatāras. Before Pṛthu, there was a great havoc of maladministration due to the vicious\[[@B39]\].

![**The reaction mechanism of lysine residues with acetaldehyde, in the absence (A) and presence (B) of a reducing agent NaBH~3~(CN)**.](1471-2091-9-32-1){#F1}

In the present study, we used carbonic anhydrase (CA) isozyme II as a model to investigate the effects of acetaldehyde reaction with the protein. CA II is a well characterized enzyme expressed in several organs, including the brain, stomach, gut, kidney, and reproductive organs, and it is highly abundant in erythrocytes \[[@B40]\]. It is one of the most efficient enzymes known in the animal kingdom, catalyzing the reversible hydration of carbon dioxide at a rate of 1.4 × 10^6^molecules per second \[[@B41]\]. CA II was our choice of model protein, because its structural and catalytic properties are well known and it contains 24 lysine residues (out of 260 amino


acetaldehyde
------------------------------------

Human blood samples and recombinant human CA II enzyme were treated with various concentrations of acetaldehyde either in the presence or absence of a reducing agent, NaBH~3~(CN). All reagents were maintained and pipeting was performed at +4°C to minimize acetaldehyde evaporation. The sample tubes containing 1/10 diluted (in H~2~O) blood or CA II enzyme with or without acetaldehyde in H~2~O were tightly sealed and incubated at 37°C for 2 hr. Then 10 mM NaBH~3~(CN) or equal volume of H~2~O was added to each sample tube, and the incubation at +37°C was continued for 22 hr. After the incubation the samples were quickly cooled down to +4°C.

Isoelectric focusing and SDS-PAGE
---------------------------------

IEF was carried out using Novex Pre-Cast vertical IEF gels (pH 3--10) (Invitrogen, Carlsbad, CA) containing 2% ampholytes. One μg1.40·10^6^          9.3            1.5·10^8^                     12
  **CA II + AA + NaBH~3~(CN)**   0.77·10^6^          9.3            0.5·10^8^                     35

Mass spectrometry
-----------------

Figure [6A](#F6){ref-type="fig"} presents an ESI FT-ICR mass spectrum measured for native CA II. A protein ion charge state distribution from 13+ to 32+ representing apo-protein (i.e., protein without a bound Zn^2+^cation)


the FT-ICR technique, unequivocal differentiation between the \'\'Schiff base\'\' (+26.02 Da) and the substituted amine (+28.03 Da), i.e. \~2-Da mass difference at 29 kDa, was possible (Figure [1](#F1){ref-type="fig"}). According to the mass spectrometry, over 90% of the enzyme molecules were modified with acetaldehyde. However, repeated measurements with the acetaldehyde-treated sample, after being stored two weeks at 4°C, indicated the presence of an unmodified CA II only, consistent with unstable character of the formed \'\'Schiff base\'\'. To further localize the modification site, both native and acetaldehyde-treated CA II samples were subjected to on-line pepsin digestion prior to mass spectrometry. Although the resulting peptide maps had 100% sequence coverage, the observed peptides were markedly larger (up to 10 kDa) in the presence of acetaldehyde, possibly due to decreased protease activity,;(function (require, exports, module, platform) {

if (module) module.exports = minimatch
else exports.minimatch = minimatch

if (!require) {
  require = function (id) {
    switch (id) {
      case "sigmund": return function sigmund (obj) {
        return JSON.stringify(obj)
      }
      case "path": return { basename: function (f) {
        f = f.split(/[\/\\]/)
        var e = f.pop()
        if (!e) e = f.pop()
        return e
      }}
      case "lru-cache": return function LRUCache () {


 return s.map(this.parse, this)
  }, this)

  this.debug(this.pattern, set)

  // filter out everything that didn't compile properly.
  set = set.filter(function (s) {
    return -1 === s.indexOf(false)
  })

  this.debug(this.pattern, set)

  this.set = set
}

Minimatch.prototype.parseNegate = parseNegate
function parseNegate () {
  var pattern = this.pattern
    , negate = false
    , options = this.options
    , negateOffset = 0

  if (options.nonegate) return

  for ( var i = 0, l = pattern.length
      ; i < l && pattern.charAt(i) === "!"
      ; i ++) {
    negate = !negate
    negateOffset ++
  }

  if (negateOffset) this.pattern = pattern.substr(negateOffset)
 numset[1][0] === '0'
      , startWidth = numset[1].length
      , padded
      , end = +numset[2]
      , inc = start > end ? -1 : 1
      , set = []

    for (var i = start; i != (end + inc); i += inc) {
      padded = needPadding ? pad(i, startWidth) : i + ''
      // append all the suffixes
      for (var ii = 0, ll = suf.length; ii < ll; ii ++) {
        set.push(padded + suf[ii])


0, len = pattern.length, c
      ; (i < len) && (c = pattern.charAt(i))
      ; i ++ ) {

    this.debug("%s\t%s %s %j", pattern, i, re, c)

    // skip over any that are escaped.
    if (escaping && reSpecials[c]) {
      re += "\\" + c
      escaping = false
      continue
    }

    SWITCH: switch (c) {
      case "/":
        // completely not allowed, even escaped.
        // Should already be path-split by now.
       // Handle the stateChar, then proceed with this one.
        self.debug('call clearStateChar %j', stateChar)
        clearStateChar()
        stateChar = c
        // if extglob is disabled, then +(asdf|foo) isn't a thing.
        // just clear the statechar *now*, rather than even diving into
        // the patternList stuff.
        if (options.noext) clearStateChar()
        continue

      case "(":
        if (inClass) {


Full text
=========

It is known that thrombolysis does not always prevent the development of early repeated thrombosis of coronary vessels. We have developed a method of extracorporeal thermal plasmamodification --- thermoplasmasorbtion (TPS), which allows to reach significant decrease of its coagulation state (complete removal of fibrinogen, reduction of activity of the external and internal coagulation factors) and decrease of blood viscosity. Is shown, that reinfusion of modificated plasma reduces platelet and red blood cells aggregation. 40 patients with myocardial infarction in acute period underwent the analysis. The TPS was applied to 20 patients (group 1) and 20 underwent conservative treatment (group 2). During clinical supervision more expressive positive dynamics changes were noted in all the patients of group 1: stenocardic cupping already in the 1st day of treatment, hemodynamic. What is the third smallest value in -9/7, u, j, 0.1?
u
Let u = 39 + -1. Let b = -2.848 - -3.048. What is the smallest value in 3, u, b, 4?
b
Let u = -3 - -4. Which is the third smallest value?  (a) u  (b) -1/69  (c) 4/5  (d) -5
c
Let j = 23000 + -22982. What is the third smallest value in 2/13, -23, j?
j
Let m = -0.24 - -6.74. Let v = 1.5 - m. Let w = -219 + 216. Which is the third biggest value?  (a) v  (b) w  (c) 1/2  (d) 3
b
Let b = 2445 - 2440. What is the second biggest value in -1/6, -43, b, -0.4?
-1/6
Let q = 0.03 - 4.03. Let


the third biggest value in -3, 0.2, -4/5, 0.3, q?
0.2
Let f be 40*(-2)/(-16) + (-47)/7 + 2. Which is the second smallest value?  (a) f  (b) -1  (c) -2  (d) 0.2  (e) 31.1
b
Let p = 210.68 + -35.58. Let n = p - 175. Which is the smallest value?  (a) -13  (b) n  (c) -5
a
Let d be (3 - 4)/((-7)/(-1)). Let b = 27 - 27.042. Let r = -2.042 - b. What is the second smallest value in r, d, -0.1?
d
Let t = 1.98 - 0.08. Let y(i) = -4786*i - 4790. Let x be y(-1). Which is the smallest value?  (a) t  (b) 4/5  (c) x
c
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