under-sampled k-space data {#mr-imaging-system-with-under-sampled-k-space-data}
-------------------------------------------------

The ground-truth (top row) objects and ProAmGAN-generated objects trained with ${4}/{5}$ k-space sampling ratio (bottom row) are shown in Fig. \[fig:fastMR\]. The ProAmGAN-generated objects have similar visual appearances to the ground-truth objects.

Objects produced by ProAmGANs and ProGANs trained with different data-acquisition designs are shown in Fig. \[fig:samplings\]. It was observed that the ProAmGAN-generated objects (top row) are visually plausible for the k-space sampling ratios that range from ${1}/{2}$ to ${1}/{1}$, while the noise and aliasing artifacts appear in the ProGAN-generated objects (bottom row).

![Top: Examples of ground-truth objects ${\mathbf{f}}$. Bottom: Examples of ProAmGAN-generated objects $\hat{{\mathbf{f}}}$ corresponding to the data-acquisition design with ${4}/{5}$ k-space sampling ratio.[]{data-label="fig:fastMR"}](images/fastMRI/fakes_F125.png){width="\linewidth"}

![ProAmGAN-generated objects (top row) and ProGAN-generated objects (bottom row). From left to right, the ProGAN and ProAmGAN trained with the k-space samplingratio of ${1}/{1}$, ${4}/{5}$, ${1}/{2}$, ${1}/{4}$, and ${1}/{8}$.[]{data-label="fig:samplings"}](images/fastMRI/fake_compare.png){width="\linewidth"}

The FID corresponding to the objects ${\mathbf{f}}$ and that corresponding to the measurement components ${\mathbf{f}}_{meas}$ for each data-acquisition design are summarized in TABLE \[table:fids\]. It is observed that the FID between ${\mathbf{f}}$ and $\hat{{\mathbf{f}}}$ increased when the k-space sampling ratio decreased, while the FID between ${\mathbf{f}}_{meas}$ and $\hat{{\mathbf{f}}}_{meas}$ were not significantly changed. This indicates that the SOMs established by ProAmGANs can be affected by the null space of imaging operator, while the variation in the measurement components can be reliably learned.

                  FID for ${\mathbf{f}}$   FID for ${\mathbf{f}}_{meas}$
  -------------- ------------------------ -------------------------------
  Full k-space


in admission to hospital in Fiji, with 8% of events (overall) deemed intentional injuries.

3.  Information regarding the specific contexts, a reliable and sustainable injury surveillance system, and the implementation and evaluation of effective interventions to reduce the burden of workplace injury should be public health priorities in Fiji.

Funding
=======

The Wellcome Trust, UK (071671) and the Health Research Council of New Zealand (04/498).

Conflicts of interest
=====================

None declared.

The authors are grateful to Dr Lepani Waqatakirewa, Permanent Secretary of Health, the staff of the Fiji Ministry of Health, all participating staff in the surveillance hospitals and the wider TRIP Project Team, including Prof. Sitaleki Finau and Prof. Rod Jackson, Dr Aumea Herman and Dr Robyn McIntyre, Ramneek Gounder, Mabel Taoi, Asilika Naisaki, Litia Vuniduvu and Nola Vanualailai.
§ 1332.  Id. For reversal, plaintiffs argue that the district court erred in granting defendant's motion for partial summary judgment and holding as a matter of Arkansas law that plaintiffs cannot recover damages for emotional distress or mental anguish based upon their claim of negligence.  Id. (Aug. 27, 1997) (memorandum opinion and partial judgment).  Jurisdiction is proper in this court based upon 28 U.S.C. § 1291.  For the reasons stated below, we affirm.

2
In their complaint, plaintiffs allege that defendant acted negligently, and thus committed legal malpractice, by first representing plaintiffs in their effort to adopt a child and then representing another individual, Maxine Sutton, in her effort to adopt the same child.  Plaintiffs allege that defendant's wrongful conduct caused a delay of several


the site more accessible and welcome to new users, but I don't see how the moderator elections are a plausible venue for that.

A:

Regardless of its inadequacy as a means in this particular election of eliminating the most experiences candidates in favour of the least experienced -- given only one of the 11 could be eliminated -- the idea of promoting a campaign to engineer a last-minute "voting plunge" in the primaries seems an extraordinarily anti-democratic proposal. It's quite blatantly a proposal to rig the election outcome.
I'm not suggesting it's the case, but * if * a hostile or unrepresentatative clique or cabal exists, and if this group controls anything in EL&U, the solution is to engage in the democratic process by electing an alternative group of candidates who,on posts, presence in chat rooms, duration of membership or simply amount of rep points completely fails to address what's wrong that needs improving. Worse, eliminating "enemy" candidates using ambush voting is a corruption of the democratic process.
Nearly 20 years as a dissident within the political arena has taught me two things above all else: (1) naked antagonism is doomed to failure, and (2) building relationships through demonstrated competence is the only path to achieving your goals.


    generic.Print<Product>(productList);

            Console.ReadLine();
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A:

What generics are for
The idea behind generics is that they do the same thing to everything you pass to it. For example, it is possible to write a generic function to take the count of any type of list, because all lists can be counted.
int GetCount<T>(List<T> source)
{
    return source.Count();
}

What generics are not for
If you have to do different things to different types, generics is not the right answer. The typical way to deal with it is with different functions, each of which accepts the type that matches its logic. The functions can have the same name ifSEO. read more…

We know very well that every single thing your brand posts on social media is effective reflection of your company’s values. It is better to know How Social Posts effectively used by Madurai Entrepreneurs. read more…


issues with the border security element of DACA and dreamers. ... If we want to talk about border security, you know, let's do it in a comprehensive immigration bill," she said.

Lawmakers said after a White House meeting that they had agreed to link the two issues , as well as border security, to a fix for DACA.

Durbin, who has taken the lead on negotiating for Senate Democrats, acknowledged that rank-and-file members had concerns.

"There's so much uncertainty. We don't have anything really nailed down. People are worried about the direction," he told reporters.

Asked if he would support the four parameters being outlined, he added that it would come down to the details of what was ultimately included.

"I'm just saying that there are ways to do things that are painlessand ways that are fatal," he said.

Hoyer also downplayed that Democrats had committed to a framework that linked family-based immigration reforms, DACA, border security and the visa lottery.

"I'm prepared to discuss resolving the issue of the Dreamers. ... Now that does not mean I am for X, Y or Z," he said.

The Trump administration announced last year that it was ending the DACA program, which allows some immigrants brought into the country as children to work and go to school if they meet certain requirements.

Durbin, however, said Tuesday night that Democrats are sticking with their demand while acknowledging the short timeframe.

"It's even worse than you think. It's 10 days away by a generous count and four of those days we're not in session," he said.

Asked about McConnell's comments,


Chapal Bhaduri

Chapal Bhaduri is the last living female impersonator in Bengali theatre and perhaps even in Indian theatre.  He did female impersonation in Jatra, a form of Bengali folk theatre. In 2010, he starred in a Bengali Film Arekti Premer Golpo which was directed by Kaushik Ganguly and written by Ganguly and Rituparno Ghosh.

Early life
He was born at Kolkata's Kali Dutta lane, as the youngest child of Tara Kumar Bhaduri, a theatre actor and Prava Devi, a theatre actress. Later in 1939, his family moved to Badamtala Lane of Goabagan area of Kolkata. He had three brothers and two sisters. Noted actor and singer, Ketaki Dutta is Bhaduri's youngest sister. With the backing of her mother, his acting career started at the age of only seven atadrenalin treatment according to the algorithm in Sampson 1--5.

**Results**: Out of 346 challenges scored as grade 4 anaphylaxis, 296 were terminated due to respiratory symptoms requiring adrenalin according to Sampson 1--5, i.e. "barky cough, hoarseness, difficulty swallowing" (laryngeal, n = 79), "wheezing, dyspnea, cyanosis" (lower resp. n = 181) or both (n = 36). Nine of the 115 patients with laryngeal symptoms were treated with adrenalin, all due to inspiratory stridor. No patients with lower respiratory symptoms received adrenalin, but the majority were treated with β2 agonists (188/217), whereas in 30 challenges, symptoms disappeared without treatment or only antihistamine for concomitant urticaria were used. Patients solely with laryngeal symptoms received β2-agonists in 16 challenges, but the majority of them (54/79) received no treatment or only antihistamine. The 36 patients with both laryngeal and lower


protein digestibility; and (iii) endogenous allergenicity, are addressed.

**Results**: Firstly, celiac disease is a well characterised non-IgE-mediated adverse immune reaction to food, and the food proteins involved, as well as the underlying molecular mechanisms, have been described in detail. Secondly, the outcome of *in vitro* protein digestibility studies is considered relevant information in the weight-of-evidence approach. To date, the "pepsin resistance test" is commonly accepted for the safety assessment considerations by risk assessors. However, EFSA has previously highlighted its limitations for the allergenicity assessment as well as for its capacity to reflect *in vivo* digestion conditions. Thirdly, high performance methodologies for protein identification and quantification are available for endogenous allergenicity.

**Conclusion**: Firstly, based on the current knowledge EFSA is working on defining a strategy to be followed for the assessmentand Translational Allergy* 2017, **7(Suppl 1)**:PD03

**Introduction**: Beside hazelnut, the English walnut (*Juglans regia*) belongs to the most important allergenic tree nuts across Europe. So far, four walnut allergens (2S albumin, vicilin, nsLTP, 11S globulin) are listed in the official IUIS allergen database. Although an association of allergic reactions to walnut with birch pollen sensitization has been reported, no cross- reactive culprit walnut allergen has been described. The aim of the present study was to identify a Bet v 1-like protein in walnut and to investigate its allergenic properties.

**Methods**: Using a Bet v 1-homologous cDNA sequence from iron walnut leaves (KJ598787) as template, a cDNA encoding a corresponding protein from *Juglans regia* kernels (Jug r PR10) was cloned by RT-PCR and 5'RACE. Recombinant^®^ Jug r PR10 protein was expressed in *E. coli* and purified by a two-step


1268 Biopolymers Interactions Assemblies, Nantes, France {#Sec79}

**Correspondence**: Mathilde Claude - mathilde.claude\@nantes.inra.fr

*Clinical and Translational Allergy* 2017, **7(Suppl 1)**:PD10

**Introduction**: Allergen structure is often modified when heating foods. Aggregation is an irreversible modification of proteins with the formation of intermolecular bonds between unfolded proteins. Depending on the balance of attractive and repulsive interactions during heating, aggregates of various morphologies may be generated. This study investigates how different way of aggregating ovalbumin modulates its allergenicity by comparing two morphologies of aggregates obtained under opposite electrostatic conditions.

**Methods**: An ovalbumin solution was extensively heated (80°C for 6 h) under opposite electrostatic conditions to form small linear and large spherical-agglomerated aggregates. In a murine model of allergy, we compared the Ig production when sensitizing mice with the aggregates and the subsequent elicitation phase upon an oralchallenge with native ovalbumin. The reactivity of specific IgE in mice sera was characterized by ELISA, Rat Basophil Leukemia assay and pepscan analysis.

**Results**: IgE production was significantly lower for the small aggregates than for the large aggregates, whereas IgG~1~ and IgG~2a~ productions didn't change. In agreement with the IgE production, both symptoms upon oral challenge and basophil degranulation with native ovalbumin were reduced for mice sensitized with small compared to large aggregates. Pepscan analysis revealed two common linear IgE-epitopes but the aggregates were similarly or differently bound and cross-linked depending on the aggregate that had been used during sensitization. These results showed that small aggregates of ovalbumin formed under repulsive electrostatic conditions displayed a lower allergenic potential than the large aggregates. The way ovalbumin aggregated also modified the


IgE repertory.

**Conclusion**: This work illustrates links between food structure and allergenic potential on parameters from the sensitization phase with some consequences on the elicitation phase of the allergic reaction. For the first time, we show that the physicochemical conditions when heating ovalbumin and consequently the aggregated structure are important parameters to consider in the context of allergy.

PD11 Residual determination of milk and egg allergens in bakery products by LC-MS/MS {#Sec80}
------------------------------------------------------------------------------------

### Rosella De Poi^1,2^, Elisa Gritti^1^, Emiliano De Dominicis^1^, Bert Popping^1^, Patrizia Polverino de Laureto^2^ {#Sec81}

#### ^1^R&D Department Italy Mérieux NutriSciences, Resana, Italy; ^2^Department of Pharmaceutical Sciences, Università di Padova, Padova, Italy {#Sec82}

**Correspondence**: Rosella De Poi - rossella.depoi\@studenti.unipd.it

*Clinical and Translational Allergy* 2017, **7(Suppl 1)**:PD11

**Introduction**: Food allergy is causing adverse health effects arising from specific immune-mediated responses, occurring reproducibly uponbovine caseins could increase their sensitising potential {#Sec92}
-----------------------------------------------------------------------------------

### Noe Ontiveros, Francisco Cabrera-Chavez {#Sec93}

#### University of Sinaloa, Culiacan, Mexico {#Sec94}

**Correspondence**: Francisco Cabrera-Chavez - fcabrera\@uas.edu.mx

*Clinical and Translational Allergy* 2017, **7(Suppl 1)**:PD15

**Introduction**: To evaluate the digestibility as well as the immunogenic and sensitizing potential of thermally treated bovine caseins (TT caseins).

**Methods**: Caseins were dry heated for 30 or 60 min at 140°C. Native and TT caseins were digested in simulated gastric fluid pH 1.2 (10 U of pepsin activity/µg of test protein). Samples of 200 µl were removed after incubation at 37°C. The reaction was quenched by addition of 70 µl of 200 mM NaHCO~3~, pH 11, and 70 µl 5× Laemmli buffer. The zero time points were prepared by quenching the pepsin in the solution before adding the test protein. The samples were subjected to


Hospital of Strasbourg, Strasbourg, France; ^7^Phadia AB, Upsala, Sweden; ^8^Paul-Ehrlich-Insitut, Federal Institute for Vaccines and Biomedicines, Langen, Germany; ^9^Medical University of Vienna, Vienna, Austria; ^10^Manchester Institute of Biotechnology, University of Manchester, Manchester, United Kingdom; ^11^University Hospital Zürich, Zürich, Switzerland; ^12^Hospital Clinico San Carlos, IdISSC, Madrid, Spain {#Sec119}

**Correspondence**: Mareen Datema - m.r.datema\@amc.nl

*Clinical and Translational Allergy* 2017, **7(Suppl 1)**:PD24

**Introduction**: Component-resolved diagnosis (CRD) has been shown to improve hazelnut allergy diagnosis. Some allergens have been associated with severity of hazelnut allergy, however few studies have reported the classification accuracy of the markers in discriminating between mild and severe subjects, especially in adults.

Our aims were:to analyze the association between sensitization to single hazelnut allergens and clinical symptom severity;to evaluate their ability to discriminate between mild and severe hazelnut allergy.

**Methods**: Subjects (n = 731) fromcashew-allergic and tolerant children (c = 0.87, 0.85 and 0.89 respectively), than specific IgE to cashew nut or SPT (c = 0.76 and 0.83 respectively). In the multivariable models inclusion of sIgE to Ana o 1, 2 or 3 increased the c-index of history and gender from 0.67 to 0.89 maximally, with increases up to 0.92 and 0.93, respectively when also specific IgE to cashew nut or both IgE and SPT were added.

**Conclusion**: The major cashew nut allergens Ana o 1, 2 and 3 are each individually predictive for the outcome of food challenge tests in cashew-allergic children.

PD28 Non-ionic iodinated contrast media-induced anaphylaxis -- Case series {#Sec129}
--------------------------------------------------------------------------

### Fabrícia Carolino, Ana Rodolfo, Josefina Cernadas {#Sec130}

#### Serviço de Imunoalergologia, Centro Hospitalar São João, E.P.E., Porto, Portugal {#Sec131}

**Correspondence**: Fabrícia Carolino - fabricia.c\@sapo.pt

*Clinical and Translational Allergy*


covering toxicity and efficacy studies at early life stages into account, by ranking and weighing all available data. Ultimately, this assessment will help to determine optimal beneficial and safe dose levels of nutritional immune interventions during early life.

**Reference** Renwick AG, Flynn A, Fletcher RJ, Müller DJG, Tuijtelaars S, Verhagen H. Risk-benefit 726 analysis of micronutrient. Food Chem Toxicol. 2004;42:1903--22.

PD34 FABER 244 IgE test in food allergy. Diagnostic accuracy for LTP proteins {#Sec147}
-----------------------------------------------------------------------------

### Claudia Alessandri^1^, Maria Antonetta Ciardiello^2^, Lisa Tuppo^2^, Ivana Giangrieco^2^, Danila Zennaro^1^, Rosetta Ferrara^1^, Maria Livia Bernardi^1^, Georg Mitterer^3^, Chiara Rafaiani^1^, Michela Ciancamerla^1^, Maurizio Tamburrini^2^, Christian Harwanegg^3^, Adriano Mari^1^ {#Sec148}

#### ^1^Centri Associati di Allergologia Molecolare - CAAM, Rome, Italy; ^2^Istituto di Bioscienze e Biorisorse, Consiglio Nazionale delle Ricerche, Naples, Italy; ^3^MacroarrayDx, Vienna, Austria {#Sec149}

**Correspondence**: Adriano Mari -positive BLG in only 21 cases. Milk sIgE showed low rates generally, but BLG sIgE seems like the most prominent. It was noted that in a third of cases sIgE to CM was negative and in almost 25% only BLG showed positive sIgE. All patients identify CM such as the triggering food, although almost a third were still tolerating yogurt. Thus in the remaining patients we performed a subsequent open challenge test with yogurt, showing good tolerance nearly 80% of them. Interestingly only after 1 year, more than a half of patients reached whole CM tolerance. The broad dietary restriction in patients with CM allergy involves important limitations in everyday life. The identification of different clinical phenotypes may have relevant implications for the clinical management, and a potential better


in a double-blind, placebo-controlled, randomized trial of peanut Oral Immunotherapy (POIT). Basophil activation test (BAT) using CD203c expression was performed after stimulation with different concentration of peanut extract. Peanut-reactive CD4+ T cell response were monitored using the CD154-based assay following stimulation with pool of Ara h 1, 2, 3, 6, 8 and 9 peanut component. Sorted peanut-reactive CD4+ T cells were then run on the Fluidigm 96.96 dynamic array chip to assess changes in gene expression.

**Results**: Positive reactions to the BAT and presence of peanut-reactive effector TH2A cells lacking CD27 expression reflect the status of sensitization to peanut, proved by Oral food challenge. Oral food challenge to peanut drastically increase the frequencies of peanut-reactive CD4+ T cells before POIT but at a lower extent in the active groupevaporation. At different time points sera were collected and analysed for the level, avidity and cross-reactivity of specific antibodies by different ELISAs. The antibody specificity was evaluated by immunoblotting and the functionality was examined by an ear swelling test.

**Results**: Both products were able to induce a specific immune response and sensitise through the slightly damaged skin without any use of adjuvant. This was evident before any post-immunisations. The sensitisation response depended on the duration of the skin application as well as on the amount of products applied to the skin. Differences in dose-response relationship were seen between products. The results confirm previous studies showing that acid hydrolysis induced new epitopes while maintaining original epitopes. Antibody avidity differed greatly between the products and showed that the shared epitopes induced


anti-IgE, lysine acetylsalicylate (L-ASA; 3.38 mM) and PGE2 (10--4 M) at several concentrations and in combinations.

**Results**: A BAT to 6 consecutive patients with Pru p 3 allergy enhanced by NSAIDs has been performed. In all of them, we observe the enhancement of basophil activation caused by the L-ASA in combination with the allergen compared to the activation caused by the allergen alone, as previously described by our group. PGE2 not only diminishes the effect of L-ASA on basophil activation (median CD63+ basophils (%) after stimuli Pru p 3+L-ASA vs Pru p 3+L-ASA+PGE2: 60.25 vs 44.60, p = 0.031) but also the activation caused by the antigen alone although not statistically significant (median CD63+ basophils (%) after stimuli Pru p 3 vs Pru p 3+PGE2: 58.2 vs 37.3, p = 0.063). In 4 of thesepotassium, magnesium and iron were within reference ranges. After 16 weeks on AAF, the averages of all mineral blood levels were again within the specified reference ranges set for the corresponding infant ages. Also the averages of total protein, albumin, prealbumin, hemoglobin and ferritin were within reference ranges. For some minerals, a number of individual values at baseline were below references, i.e. calcium (n = 1), phosphorus (n = 1), chloride (n = 1), and sodium (n = 1), whereas at week 16 none of these minerals had individual values below reference ranges.

**Conclusion**: This study shows that an AAF with or without synbiotics, which have been reported previously to be equally tolerated and to support normal growth \[1,2\], are effective in managing an adequate mineral status in CMA infants.

**References** Harvey BM, Langford JE, Harthoorn LF, Gillman SA,


allergen exposures, including those to which a patient has been exposed on multiple occasions without systemic or local reaction.

It could be theorized that new sensitization to previously tolerated food antigens with resultant anaphylaxis could be associated with underlying mast cell activation disorders in adults without a history of atopy, particularly when presenting with profound hypotension. Further research is needed into the incidence of adult onset IgE mediated food allergies, anaphylaxis, and the rate at which it is associated with underlying mast cell activation, particularly given the association with MCAS and a heightened risk for a more severe anaphylactic reaction.

**Consent to publish**: The individual described in the above case report has completed and signed a consent form for publication and presentation, currently stored at the Allergy and Immunology clinical officesthe correlation between red gram allergy and AD, we have studied the coexistence of AD and food allergy in red gram allergic patients (n = 210) and healthy individuals (n = 10 as a control) at the Department of Respiratory Medicine, King George Medical University (KGMU), India. Further, BALB/c mice were sensitized with red gram crude protein extract (CPE) via intraperitoneal route to explore the red gram induced AD like symptoms. Serum levels of specific IgE and IgG1 antibodies were measured by indirect ELISA. Anaphylactic signs and symptoms were evaluated 40 min after the challenge by two investigators using the scoring. Histopathological responses were analyzed in the skin of treated mice. Further, mast cell count was performed in the skin. Moreover, expression levels of cytokines, transcription factors and filaggrin were studied in the


expressions of GATA-3, T-bet as well as filaggrin were observed at the protein levels in the skin of treated mice. We have endeavored to understand the allergenic potential of red gram in the context of AD because in our previous study, we have observed the health concern related to skin in the pigeon pea's allergic patients. Increased levels of specific IgE and IgG1 antibodies were evident in treated group as compared to control group; illustrate the allergenic potential of red gram CPE. In our study, treated group mice have shown significantly fall in body temperature (4--5 °C) as well as symptoms of systemic anaphylaxis upon challenge with red gram CPE. Histopathological results showed the AD like pathological changes, including epidermal thickening, mixed inflammatory cellular infiltration along with hyperplasia indicatingup to 54.3 ± 6.76% for SWAB and up to 36.6 ± 5.5% for CARD (p \< 0.001). As regards BAFF, values were stable until T21 while at T28 there was a decrease of up to 77.1 ± 6.3% for SWAB and up to 63.7 ± 4.5% for CARD (p \< 0.001). According to Finkelman, there is a pathway of activation of immune system mediated by IgG, FcγRs, macrophages, and PAF. BAFF is a member of the tumor necrosis factor superfamily and an important regulator of peripheral B cell survival, maturation and immunoglobulin class-switch recombination. Many studies suggest that BAFF might modulate immune inflammation and could probably be one of the cornerstones of this IgG pathway of immune reaction. BAFF and PAF have both already been linked in non-atopic subjects to food reactions, supporting the possibility that these


and 10% had a negative one, these patients underwent open OFC which turned out positive. Sensitization to *Quercus robur and Alnus glutinosa* were the most frequents (40%), followed by *Fraxinus excelsior* (35%) and *Betula verrucosa* (30%). There is little knowledge about FPS in Mexico and there are no previous studies in pediatric population. We found that FPS affects males and females equally, being more frequent between 6--10 years. When compared with international literature, the prevalence is similar and we also found apple and peach as the most frequent foods implicated. Although, we also found banana as a frequent food responsible for FPS, similar to what is reported in the Mexican study performed in adults. Contrary to studies performed worldwide, we found birch sensitization in only 30% in FPS, beingdiagnostics for WA. However, they are affected by a low predictive value. In particular, their low sensitivity can be explained by the fact that the commercial test reagents are mixtures of water/salt-soluble wheat proteins that lack allergens from the insoluble gluten fraction.

**Case report**: In our unit of celiac disease and related conditions to gluten we visited in one year about 400 patients. Of these 113 they were not celiac but were investigated for suspected non-celiac gluten sensitivity. After in vitro tests for the exclusion of celiac disease, the same patients underwent allergologic workup consists of: skin prick tests for foods including wheat (Alk-abello), LTP (lipid transfer protein) (peach Alk abello), alpha amylase, wheat flour, barley, corn, rice, grass pollen and histamine. Also all they performed patch tests for


from the city of Batumi.

**Methods**: The study was conducted with children population, in Batumi. The random sampling was applied in the study to ensure representative sample and the cross section method of epidemiological survey was used. At the first stage of the survey 840 children aged from 6 months to 7 years, were questioned. Data were collected through the face-to-face and phone interviews. At the second stage of the survey, the subjects of study were the part of the population, who revealed the clinical signs of food allergy for the last 12 months. The causal factors were revealed on the basis of answers to the questionnaire, anamnesis data, specific IgE measurements and skin prick tests. The risk factors were studied on the basis of case control studies.

**Results**: Skin manifestation (76%) ofreactions; all children in this audit had allergic co-morbidities and food allergy was the most frequent one. Children who have both asthma and a food allergy are at greater risk for anaphylaxis. Severe reactions requiring treatment with adrenaline was common, but few children required multiple doses of adrenaline. OFC's, which serve as the gold standard diagnostic modality are generally safe but severe reactions do rarely occur for which adrenaline treatment is required.

PP027 Almond and peanut allergy: how commonly sensitised and how commonly reactive? {#Sec294}
-----------------------------------------------------------------------------------

### Sofia Kostoudi, Nikolaos Douladiris, Nikolaos Kitsioulis, Emmanouil Manousakis, Nikolaos G. Papadopoulos, Paraskevi Xepapadaki {#Sec295}

#### Allergy Unit, 2^nd^ University Pediatric Clinic, University of Athens, Athens, Greece {#Sec296}

**Correspondence**: Nikolaos Kitsioulis - drnok21\@gmail.com

*Clinical and Translational Allergy* 2017, **7(Suppl 1)**:PP027

**Introduction**: Tree nut and peanut allergy are responsible for


a large number of severe IgE-mediated reactions. Almond is widely used in manufactured and homemade sweets or as a snack, while peanuts, alone or in other products are increasingly consumed in the Greek diet.

We aimed to assess sensitization and reactivity patterns to peanut and almond in children with a reported immediate reaction after consuming nuts or peanuts (cashew, pistachio, walnut, hazelnut, peanut and almond).

**Methods**: We retrospectively studied data on sensitization patterns by means of skin prick tests (SPTs) and specific (s) IgE in children with symptoms suggestive of IgE mediated allergic reaction following consumption of tree nuts or peanut, confirmed by positive IgEs and/or SPTs, visiting our Unit between 2012 and 2015.

**Results**: 204 children were included, 136 males, mean aged 8.2 ± 3.2 years, in whom 264 reactions were recorded. Themost common provocative agent was pistachio (24.9%) and cashew (24.5%), while hazelnut and walnut were associated with 16.1% and 15.4% of the reactions respectively. Almond was the least reported (2.7%, n = 7), followed by peanut (13.6%, n = 36). Among the 7 patients with a reported reaction to almond sIgE was 27.4 kU/L (SE = 12.31), while SPT max diameter was 5 mm \[3.22, 6.77\]. 93 of the sensitized children to almond (with no reported reaction), had sIgE of 2.6 kU/L \[1.75, 3.45\], while SPT max diameter was 5.16 mm \[4.68, 5.64\]. Open food challenges (OFCs) in this population were negative. 36 children with a reported peanut reaction, had sIgE to peanut 45.93 kU/L, 95% CI \[31.75, 65.11\] and SPT and max diameter was 10.8 mm \[9.12, 12.49\]. 53 of the sensitized children to peanut (with no reported reaction),


increasing prevalence. Studies have investigated the link between intake of certain food among ASD patients and onset of adverse reactions. Results of these studies are varied and conflicting. This is the first local study on the prevalence of food allergies among these patients.

This study aims to determine the prevalence of food sensitization, IgE-mediated and non-IgE-mediated food allergies among pediatric ASD patients. It also aims to determine the prevalence of perceived food allergies, and its triggers and the types of reactions of perceived food allergies and on open food challenge.

**Methods**: This is a cross-sectional, prospective study. Pediatric patients diagnosed with Autism Spectrum Disorders were enrolled in the study. Excluded were: children with uncontrolled asthma, with a recent anaphylactic reaction, and those on chronic high dose steroid therapy. Required samplethe anaphylactic reaction were investigated with logistic regression analysis.

**Results**: A total of 92 children (40 boys, 44%) with a median age of 7 years (range 1--17 years) who met the criteria for anaphylaxis (n = 85) or who were treated with epinephrine (n = 7) were included in this study. Thirty-three children (39%) with anaphylaxis were treated with epinephrine. Factors significantly associated with epinephrine treatment were younger age (p = 0.001) and lower airway symptoms (p = 0.001). Gastro-intestinal symptoms and a history of an allergic reaction to the tested allergen were significantly associated with the lack of epinephrine treatment (p \< 0.001 and p = 0.043, respectively). The most severe allergic type of reaction during a food challenge test is anaphylaxis, for which the recommended treatment is epinephrine. However, only about half of the children with anaphylaxis received epinephrine


for managing allergy in schools around Leicester, UK {#Sec330}
-----------------------------------------------------------------------------------------------------

### Gary Stiefel^1^, Jean Tratt^2^, Kerrie Kirk^1^ {#Sec331}

#### ^1^Leicester Royal Infirmary, Leicester, United Kingdom; ^2^Leicester Partnership Trust, Leicester, United Kingdom {#Sec332}

**Correspondence**: Gary Stiefel - garystiefel\@icloud.com

*Clinical and Translational Allergy* 2017, **7(Suppl 1)**:PP041

**Introduction**: The children's allergy service in Leicester continues to work with local authorities (LAs) to ensure there are guidelines in managing allergy, including emergency action plans. The aim of this survey was to ascertain whether school staff had the appropriate infrastructure in place to manage children with allergies.

**Methods**: Two LAs were sent a link to an online questionnaire to all schools under their jurisdiction (377 schools). The schools were requested to circulate the questionnaire to all members of staff to complete.

**Results**: 234 staff members completed the survey. Off those 166by the caregivers.

**Results**: Data of 127 children (59% male; median age \[interquartile range, IQR\] 5 \[7\] years); 64% atopic (48% allergic rhinitis; 38% asthma and 27% atopic eczema); was collected. A total of 235 OFC were scheduled during this period and only 186 were performed and 137 were negative. The major foods tested were with cow's milk (29%), hen's egg (26%), fish (14%) and crustaceans (11%). Data on FCS was obtained in 97.3% of the total 235 OFC scheduled during the study period. The mean time (±std) between the OFC and the assessment of FCS was 13 ± 6.9 months. Food avoidance was maintained in 26.3% of the 137 negative OFC. Food rejection was the main reason (44%), followed by the fear of reaction by caregivers (35%). Food avoidance was related


lack of sufficient quality data at the time. As part of the VITAL^®^ update process, the threshold database was supplemented with additional data collected from 2011 to 2016. The results of that update are presented here.

**Methods**: Individual NOAELs and LOAELs from published clinical literature were reviewed and verified by scientists at the Food Allergy Research & Resource Program (FARRP) at the University of Nebraska and at TNO in the Netherlands. Publications from 2011 to 2016 were selected based upon previously outlined criteria and focused on low-dose oral food challenges. Additional unpublished clinical records from TNO and FARRP collaborators were also used to supplement the published data. Where possible, population based threshold distributions were updated.

**Results**: Over 1300 data points were added from data made available during 2011--2016. The TNO-FARRP\< 0.05). 14 hazelnut allergic children had higher specific IgE to rCor a 8 and rCor a 9 than 25 hazelnut tolerant children (p = 0.006 and p = 0.0009, respectively) and significantly lower specific IgE rCor a 1 than hazelnut tolerant children (p \< 0.0001). Three soy allergic children had significantly higher specific IgE to nGly m 5 and nGly m 6 than 42 soy tolerant children (p \< 0.001 and p = 0.003, respectively). Two wheat allergic children differed from 50 wheat tolerant in rTri a 19, rTri a 14, tTri a aA_TI (p from \< 0.001 to\< 0.05). 6 children with anaphylaxis to different fruit had significant higher n/r Pru p 3 than 25 fruit tolerant children (p = 0.03). 18 children with OAS associated with fruit had significantly higher specific IgE to rPru p 1, rMal


2017, **7(Suppl 1)**:PP088

**Introduction**: To establish the knowledge that exists among adolescents in our region about anaphylaxis and its treatment. To determine the usefulness of a theoretical and practical workshop on the management of anaphylaxis and adrenaline auto-injectors among adolescents.

**Methods**: We conducted two methodological approaches: a descriptive study of knowledge about anaphylaxis in a cohort of secondary students through a questionnaire; an analytical quasi-experimental study comparing the previous results with those obtained after conducting a workshop on anaphylaxis. The workshop consisted of a theoretical and practical training of 45 min.

**Results**: We included 115 teenagers from 13.74 years on average, being the 13.9% of them allergic to some food. Before the workshop, the 82.6% of teenagers recognized anaphylaxis symptoms. Later, this percentage reached the 87.2%. The 41.7% of them considered the adrenalinthe Network for Online Registration of Anaphylaxis (NORA) were analyzed for German speaking countries (Germany, Switzerland and Austria). We compared data from patients aged ≥65 (elderly) with data from patients aged 18--64 (main adult group) in terms of elicitors, clinical symptoms, comorbidities and emergency treatment.

**Results**: Between July 2007 and March 2016, anaphylaxis was registered in 939 elderly and 4665 of other adult patients. Insect venom was the most frequent trigger in both groups (elderly: 60% vs. adults: 52%), followed by drugs (24% vs. 21%) and food items (10% vs. 17%). Within the group of insects yellow jacket (72% vs. 73%) and in the group of drugs analgesics (38% vs. 40%) were the most common elicitors. For food anaphylaxis hazelnut (16%) was the most frequent elicitor in the elderly,


Plovdiv, Plovdiv, Bulgaria; ^3^Department of Allergology and Occupational Medicine, Medical University Plovdiv, Plovdiv, Bulgaria {#Sec438}

**Correspondence**: Mariya Ivanovska - marijaku87\@yahoo.com

*Clinical and Translational Allergy* 2017, **7(Suppl 1)**:PP092

**Introduction**: The aim of this study is to determine the incidence of anaphylaxis, acute urticaria and angioedema during of years 2012--2015 in patients with diabetes mellitus type 2.

**Methods**: We performed a prospective study of the frequency of anaphylaxis, acute urticaria and angioedema during of years 2012--2015 in patients with diabetes mellitus type 2. A total of 83 patients with diabetes mellitus type 2 of the district of Plovdiv were included in the study.

**Results**: With a history of anaphylaxis were 4.8% from diabetics. With history of acute urticaria and angioedema were 26.5% diabetics. In all diabetics with a history of anaphylaxis, the symptoms were dueefforts to reduce it and could provide clues for its prevention.

PP100 Paracetamol: a rare culprit in anaphylaxis {#Sec460}
------------------------------------------------

### Ana Rodolfo, Fabrícia Carolino, Eunice Dias de Castro, Josefina R. Cernadas {#Sec461}

#### Immunoallergology Department, Centro Hospitalar de São João, E.P.E., Porto, Portugal {#Sec462}

**Correspondence**: Fabrícia Carolino - fabricia.c\@sapo.pt

*Clinical and Translational Allergy* 2017, **7(Suppl 1)**:PP100

**Introduction**: Anaphylaxis to paracetamol is rare and the underlying mechanisms are poorly understood. We aimed to review the cases of anaphylaxis to paracetamol in our Drug Allergy Unit (DAU) in the last five years.

**Methods**: The authors did a retrospective analysis of all cases of anaphylaxis to paracetamol studied in our DAU between January 2011 and December 2015. The data were analysed using SPSS, version 21.

**Results**: Twelve adult patients with anaphylactic reaction to paracetamol were studied (67% males, aged


on IL-4 and IL-10 DNA methylation pattern. These epigenetic mechanisms might be involved in the positive effects of this dietary strategy on the acquisition of oral tolerance.

PP109 The tree nut components IgE profile in patients suspected of food allergy {#Sec478}
-------------------------------------------------------------------------------

### Adam Wawrzeńczyk, Magdalena Żbikowska-Gotz, Michał Przybyszewski, Anna Wawrzeńczyk, Zbigniew Bartuzi {#Sec479}

#### Department of Allergology, Clinical Immunology and Internal Diseases, L. Rydygier Collegium Medicum, Bydgoszcz NCU, Bydgoszcz, Poland {#Sec480}

**Correspondence**: Adam Wawrzeńczyk - adanw23\@gmail.com

*Clinical and Translational Allergy* 2017, **7(Suppl 1)**:PP109

**Introduction**: According to the EuroPrevall (The prevalence, cost and basis of food allergy across Europe) report tree nut tree nut allergy is one of the most common food allergens. It is connected mainly with cross-reactions with tree pollen-based Central Europe and North- Eastern Europe, but also of severe anaphylactic reaction relatedAssociation of *FLG* mutations with food allergy was analyzed by logistic regression using the Multicenter Allergy Study (MAS) as control population.

**Results**: *FLG* mutations were associated with allergies to diverse foods (hen's egg, peanut, cow's milk) with similar risk estimates (odds ratios between 2.5 and 2.7, P‐values \<10^−5^). Interestingly, this effect remained significant after adjusting for the eczema status. We did not observe an association of *FLG* mutations with polyvalent compared to monovalent food allergy. Mucocutaneous, gastrointestinal, respiratory, and cardiovascular responses during double‐blind placebo controlled food challenge were documented in a standardized fashion. The *FLG* effect increased with the number of organ systems involved suggesting an effect on severity of the allergic response.

**Conclusions**: Since *FLG* mutations cause a skin barrier defect, our results suggest a pathway for food allergy


allergy in children in Portugal and rarely begins in adults. Allergy to fish in adulthood can be caused by an occupational exposure.

**Case report**: The authors describe the case of a 29 years old women, with an unusual work (since age of 23): animal handler at an Aquarium, she prepares raw fish (capelin) to feed amphibious without use of personal protection measures (gloves) and also dives in the tanks for cleaning. She has personal history of rhinoconjunctivitis since adolescence and hand eczema since three years ago. In the last two years she started having episodes of facial/lip angioedema and/or nausea/vomiting and the last one with stridor and dyspnea, always after the ingestion of cooked fish meals. Contact urticaria to jellyfish and corals was also reported. Skin prick tests (Bial -Katrine L. Bøgh {#Sec537}

#### National Food Institute, Technical University of Denmark, Søborg, Denmark {#Sec538}

**Correspondence**: Charlotte Madsen - charm\@food.dtu.dk

*Clinical and Translational Allergy* 2017, **7(Suppl 1)**:PP136

**Introduction**: Hydrolysed wheat proteins have provoked IgE mediated symptoms after skin exposure or ingestion in subjects tolerant to wheat. Acid hydrolysed wheat protein in a facial soap has been described to break tolerance to wheat. We have previously investigated the sensitising capacity of wheat gluten (G), enzymatic hydrolysed (EHG) and acid hydrolysed gluten (AHG) in naïve Brown Norway rats (Kroghsbo et al. 2014). The aim was to study the influence of wheat tolerance on the sensitising capacity of G, EHG and AHG.

**Methods**: Rats were bred for at least two generations on ordinary wheat-containing rat chow. After weaning the rats were kept on chow and then


equivalent blinding matrix was used and rice powder was added to match the texture. If no reaction occurred during the titrated DBPCFC, a cumulative dose of 45 g heated HE was given another day. Children with allergic reaction to raw HE who tolerated at least 0.4 g of raw HE during the challenge were eligible for a challenge with heated HE.

**Results**: 50 children with allergic reaction to raw HE performed a DBPCFC with heated HE according to the protocol described above within 3 month after their positive DBPCFC to raw HE. The challenge meal was well accepted by every child. 43/50 children (86%) showed no allergic reaction to heated HE whereas 7/50 (14%) were allergic to raw and heated HE.

**Conclusions**: Our standardized protocol for a DBPCFC with heated HE showed a^1^Faculty of Health Science and Physical Education, Witelon State University of Applied Sciences, Legnica, Poland; ^2^Faculty of Human Nutrition, University of Environmental and Life Sciences, Wroclaw, Poland {#Sec574}

**Correspondence**: Monica Maćków - dietmonica\@gmail.com

*Clinical and Translational Allergy* 2017, **7(Suppl 1)**:PP152

**Introduction**: The aim of this pilot study was to assess the knowledge of parents of children with food allergies on the elimination diet and allergens, and knowledge of the sources of information about food allergy.

**Methods**: The pilot study was conducted from May to August 2016 among 86 parents in Lower Silesian in Poland, whose children have food allergies. Surveys were distributed to parents in hospitals and nursery school. They were a group of women and men in the age range 18--50 years. Parents' knowledge was verified by a questionnaire, which has been


high diagnostic accuracy in verifying or excluding symptomatic peanut allergy, and high levels are considered to predict serious allergic reactions. In our experience some adult patients with peanut allergy suffer disabling fear of peanuts, having been taught that they risk a severe allergic reaction upon airborne exposure of, or consumption of peanuts.

**Case report**:Female, 24 years old with asthma. The patient had been told to exclude peanuts from her diet and not to be in a room where peanuts are consumed. She had always carried an adrenaline auto-injector. Current level of Ara h2 was 9.3 kU/L. She had never experienced a severe allergic reaction and was eager to find out how she would react to accidental intake of peanuts.Following a strict protocol, she consumed one peanut and experienced instantly some mild(SPPT) (raw hake: 7 mm; cooked hake: 5 mm; histamine: 4 mm) performed at another hospital. No further tests were conducted and he was instructed by his previous physician to avoid all fishes. A more detailed history at our out-patient clinic revealed that he continued to ingest and tolerate fish. Also, the parents were eating barnacles in the second episode and they could not guarantee the absence of cross contamination with the son's food. One year after the last episode, SPPT with barnacle were performed and they were positive (raw meat: 13 mm, cooked meat: 13 mm, histamine: 4 mm). Parents refused oral provocation test (OPT). Comment: This case illustrates the importance of hidden allergens, cross contamination and a detailed history in order to establish a correct diagnosis and unnecessary dietary restrictions. *Case 2:*


authors' best knowledge this would be the forth case of anaphylaxis to a polyhexanide irrigation solution. No reports of severe immediate hypersensitivity reactions to topical betaine formulations were found in the literature.

**Consent to publish**: The authors state they have obtained patient's informed oral consent for presentation and publication of the present clinical case.

PP159 Galactose-α-1,3-galactose (alpha gal) allergy without anaphylaxis: a case report in Brazil {#Sec594}
------------------------------------------------------------------------------------------------

### Renata R. Cocco, Luis F. Ensina, Carolina S. Aranda, Dirceu Solé {#Sec595}

#### Federal University of São Paulo, São Paulo, Brazil {#Sec596}

**Correspondence**: Renata R. Cocco - renata.cocco72\@gmail.com

*Clinical and Translational Allergy* 2017, **7(Suppl 1)**:PP159

**Introduction**: Several studies suggest that tick bites are a cause of IgE antibody responses to alpha-gal in the United States, Europe, Asia and Australia. Delayed-onset reactions, especially anaphylaxis, have been reported todue to those symptoms required hospitalization. Most recent episode of anaphylaxis occurred in 2015, also after physical exercise (shoveling coal). In general episodes of urticaria occur every 2--3 months. During diagnosis we performed skin prick tests (SPT) with inhalant and food allergen. We also established the level of total IgE, specific IgE to Dermatophagoides pteronyssinus, Dermatophagoides farinae, bee and wasp venom, gluten, wheat and rye flour and ImmunoCap ISAC. Patient also performed exercise provocation test on an empty stomach and after eating bread. SPT were positive with wheat flour (4/25 mm) and rye flour (4/5 mm). The concentration of allergen-specific IgE against wheat flour (before exercise provocation test) was 0.18 IU/ml and rye four 1.06 IU/ml, after provocation test respectively 0.18 IU/ml and 1.21 IU/ml. ImmunoCap ISAC reveled elevated level of IgE specific to wheat


negative, with a clinical reaction upon re-exposure. This can be due to priming or maturation of the immune system. But the course of events leading to reactivity or cross-reactivity towards a previously tolerated food item is not fully clarified.

**Case report**: A 1-year-8-months-old girl was referred to an allergy center after an allergic reaction to hazelnuts. She had sIgE (Thermo Fisher Scientific, Uppsala, Sweden) towards other tree nuts that she had never ingested, and kept a nut-free diet until subsequent OFCs (Fig. [8](#Fig8){ref-type="fig"}). After two negative pistachio-OFCs, one positive cashew-OFC and one negative walnut-OFC, a 20 fold increase in sIgE was observed towards all nuts challenged with including hazelnuts (later hazelnut-OFC was positive). Regular intake of the food tolerated in an OFC is normally recommended. But due to the increasefoods containing Bet v 1-like allergen components: *Rosaceae* fruits (apple, pear, peach, apricot, plum, cherry, strawberry, raspberry), exotic fruits (kiwi, persimmon, Jack fruit), *Betulaceae* (hazelnut) and *Rosaceae* (almond) nuts, *Apiaceae* vegetables (celery, carrot), *Fabaceae* legumes (peanut, soybean, chickpea) and tomato.

**Consent to publish**: Written informed consent was obtained for presentation and publication.

PP176 Recurrent anaphylaxis in shrimp and cocktail-tomato allergic patient {#Sec630}
--------------------------------------------------------------------------

### Natalia Ukleja-Sokolowska^1^, Ewa Gawronska-Ukleja^1^, Magdalena Zbikowska-Gotz^1^, Zbigniew Bartuzi^1^, Lukasz Sokolowski^2^ {#Sec631}

#### ^1^Department of Allergology, Clinical Immunology and Internal Diseases, L. Rydygier Collegium Medicum, Bydgoszcz NCU, Bydgoszcz, Poland; ^2^Division of Ergonomics and Exercise Physiology, L. Rydygier Collegium Medicum, Bydgoszcz NCU, Bydgoszcz, Poland {#Sec632}

**Correspondence**: Natalia Ukleja-Sokolowska - ukleja\@10 g.pl

*Clinical and Translational Allergy* 2017, **7(Suppl 1)**:PP176

**Introduction**: Most important tomato allergens are: profilin Lyc e 1 and nsLTP Lyc e 3. López-Matas et


package OpenXPKI::Server::API2::Plugin::Crypto::password_quality::CheckEntropyRole;
use feature 'unicode_strings';

=head1 NAME

OpenXPKI::Server::API2::Plugin::Crypto::password_quality::CheckEntropyRole -
Check password entropy

=head1 CHECKS

This role adds the following checks to
L<OpenXPKI::Server::API2::Plugin::Crypto::password_quality::Validate>:

C<entropy>.

Enabled by default: C<entropy>.

For more information about the checks see
L<OpenXPKI::Server::API2::Plugin::Crypto::password_quality>.

=cut

use Moose::Role;

# Core modules
use POSIX qw(floor);

# Project modules
use OpenXPKI::Debug;

requires 'register_check';
requires 'password';
requires 'enable';

use constant {
    OTHER => '__unlisted character class',
    UNICODE_ASSIGNED_CHARACTERS => 143924,
};

has min_entropy => (
    is => 'rw',
    isa => 'Int',
    lazy => 1,
    default => sub { 60 },
);

has _unicode_blocks => (
    is => 'ro',
    isa => 'HashRef',
    traits  => ['Hash'],
    init_arg => undef,
    lazy => 1,
    builder => '_build_unicode_blocks',
    handles => {
 0xA69F, 'Cyrillic Extended-B' ],
        [ 0xA6A0 => 0xA6FF, 'Bamum' ],
        [ 0xA800 => 0xA82F, 'Syloti Nagri' ],
        [ 0xA830 => 0xA83F, 'Common Indic Number Forms' ],
        [ 0xA840 => 0xA87F, 'Phags-pa' ],
        [ 0xA880 => 0xA8DF, 'Saurashtra' ],
        [ 0xA8E0 => 0xA8FF, 'Devanagari Extended' ],
        [ 0xA900 => 0xA92F, 'Kayah Li' ],
        [ 0xA930 => 0xA95F, 'Rejang' ],
        [ 0xA960 => 0xA97F, 'Hangul Jamo Extended-A'


$entropy = floor($bits_per_char * $eff_len);
    }
    ##! 32: "Password entropy: $entropy"
    return $entropy;
}

sub _get_char_class {
    my ($self, $char) = @_;
    for my $block (grep { $_ ne OTHER } $self->unicode_block_names) {
        return $block if $char =~ $self->unicode_block($block)->{regex};
    }
    return OTHER;
}

1;
figures in the paintings, though not abstract, are sketchily formed, accentuating the whirl of movement that characterises the frenetic action of a two-minute round.

The paintings are small, but the rings seem larger-than-life, the backdrops a blur of colour and darkness — accentuating those moments when the ring is all there is, a world in itself.

“I’ve done figures moving in big landscapes before,” says Walker, “I’ve done tiny runners, or, years ago, in India, figures working in paddy fields, but with the boxing paintings I wanted to keep them small, because the sport is really all about these intense moments.

“Whether it’s the trainer giving the advice to the contestant between rounds, or walking to the ring, the intent; or capturing that respect they all really uphold — shaking hands


with standard reservations for minerals and petroleum. The express effect of the stipulation in the trial court was to eliminate the state's environmental involvement in the fill of the subject property and to abstain totally in favor of the U.S. Corps of Engineers.
Florida precedent at the highest judicial level provides an answer as to the burden of proof, although not the ultimate issue here.
In Zabel v. Pinellas County Water and Navigation Control Authority, 171 So.2d 376 (Fla. 1965), the Authority denied a dredge and fill permit for approximately 11.5 acres of submerged land in Boca Ciega Bay, upon which the owners wished to extend a trailer park situated on their upland property. The supreme court held that the denial of a permit to fill amounted to a taking     echo mysql_error();
            die;
        }

        if ( !$query ) {
            echo mysql_error();
            die;
        }

        $data = array();
        for ($x = 0; $x < mysql_num_rows($query); $x++) {
            $data[] = mysql_fetch_assoc($query);
        }

        echo


      {
            _includeScale = ConvertUtil.ToBool(args);

            return typeof(Trans);
        }

        public object Get(object target)
        {
            var trans = GameObjectUtil.GetTransformFromSource(target);
            if (trans != null)
            {
                return Trans.GetGlobal(trans);
        in high school. Out in the real world, his job and his relationships are going nowhere. He’s the guy who women love and leave, not the one who makes them think of forever—until Lauren comes back to town, bringing old feelings and new dreams with her.

Because the only thing more important than figuring out where you truly belong is finding the person you were meant to be with.

Some people wait decades to meet their soul mate. Courtney Kaufman suspects she met hers in high school—only to lose him at seventeen. Since then, Courtney’s social life has been a series of meaningless encounters, though she's made a few close friends along the way. Especially her roommate, Max Cooper, who oozes damaged bad-boy vibes from every pore.

Max knows about feeling


* `lookup` *domain*
    Lookup the IP addresses of all nodes that claim to satisfy the domain.
    The first call will start the search.

  * `announce` [*domain*[:*port*] [*minutes*]]
    Announce that this instance is associated with a domain
    and an optional port. The default port is random (but not equal 0).
    A missing *minutes* argument trigger a single announcement. Negative *minutes*
    last for the entire runtime. Otherwise the lifetime is set *minutes* into the future.
    No arguments will announce all identifiers at once.

  * `import` *addr*
    Send alinks in the web browser or for command line tools like ssh. For this, `/etc/nsswitch.conf` need to be configured:

  * Copy libnss_kadnode.so.2 to /lib/. Other libnss_*.so files are likely to be there as well.
  * Edit `/etc/nsswitch.conf` to include `kadnode` in the `hosts:` line before entry `dns`:
    * `hosts: kadnode dns`

## Automatic Port Forwarding

If KadNode runs on a computer in a private network, it will try to establish a port forwarding for the DHT port and ports used for announcements.
Port forwarding only works if UPnP/NAT-PMP is compiled into KadNode and is supported by the gateway/router.
This is useful to make a local service (e.g. a web server) reachable from the Internet without the need to
configure port forwardings manually.

## LICENSE

  MIT/X11


England’s women’s footballers have captured the hearts of the nation to such an extent that their World Cup semi-final against USA on Tuesday night will be the most watched TV event of the year, Phil Neville has predicted.

Nearly eight million people watched the team’s quarter-final victory against Norway but Neville, the England manager, expects 10 to 12 million to watch the biggest game in the history of England women’s football.

That would exceed the season finale of the police corruption drama Line of Duty, which had 9.6 million viewers in June – the biggest overnight TV rating of the year so far.

FA furious after US officials are caught in England’s World Cup hotel Read more

“It’s our biggest strength as a nation that we come together as a country inwork. The book also provides a glossary of key terms and concepts, making the complexity of Habermas’s thought accessible to a broad readership.

Buy it here.

Red International and Black Caribbean

By Margaret Stevens

his is the history of the black radicals who organised as Communists between the two imperialist wars of the twentieth century. It explores the political roots of a dozen organisations and parties in New York City, Mexico and the Black Caribbean, including the Anti-Imperialist League, and the American Negro Labour Congress and the Haiti Patriotic League, and reveals a history of myriad connections and shared struggle across the continent.

This book reclaims the centrality of class consciousness and political solidarity amongst these black radicals, who are too often represented as separate from the international Communist movement which emerged after


1. Field of the Invention
The present invention relates to a peer-to-peer (P2P) type communication system including a plurality of node devices mutually communicable through a network.
2. Discussion of Related Art
There is known a technology called “Application Layer Multicast (ALM)” where content data stream is relayed and delivered while a delivery (broadcast) route of content data is managed in an application layer. For example, in a tree-type broadcast system which is disclosed by Patent Document 1, plural node devices participating in the system form a plurality of hierarchy levels with a broadcast station (e.g. broadcast device) ranked as a top and are connected in a tree-like form through a communication means at the same time. Content data broadcasted (streamed) from the broadcast station are sequentially transferred from node devicesother farmland classes for the entire South Jiangsu Province during 1985--2010. The figure was generated by N.X. and P.J. using GUIDOS (Vogt P, 2014. GuidosToolbox (Graphical User Interface for the Description of image Objects and their Shapes): Digital image analysis software collection available at the following web site: <http://forest.jrc.ec.europa.eu/download/software/guidos>) and Adobe Photoshop CS5 (<http://www.adobe.com/cn/products/photoshop.html>).](srep11797-f3){#f3}

![The study area (left), (**a**) an overall terrain view, (**b**) a remote sensing image (2010), and (**c**) a map showing major roads, railways, water bodies, and major cities in the study area. The map data was downloaded from [http://www.geodata.cn and http://www.gscloud.cn/](http://www.geodata.cnandhttp://www.gscloud.cn/) (Remote Sensing Images, Administrative Boundaries, Digital Elevation Model and etc.). The figure was generated by Y.D. using ArcMap 10.0 (<http://www.esrichina.com.cn/>).](srep11797-f4){#f4}

###### Changes in farmland area and relative proportion in South Jiangsu Province from 1985 to


of the matrix, E, indicated by E−1, and multiply it by the vector of measured voltages Y, as shown in the equation X=E−1*Y. However, not every matrix can be inverted. Additionally, the condition number of the excitation matrix is important, since a high condition number will result in the amplification of errors and a less perfect estimation of the capacitance values. Generally, the excitation matrices in the prior art do not have condition numbers lower than two. As the condition number of the excitation matrix increases, the signal-to-noise ratio (S/N) deteriorates.
In a mutual capacitance touch screen panel with cross bar ITOs, horizontal row ITO traces are typically very broad and are orthogonally placed under narrow vertical column ITO traces. The vertical-to-horizontal size aspect ratio of mutual capacitance rectangularfor extracting the touch image profile from the captured column matrix no longer operates on the correct time aligned elements in the column matrix. These misalignments or time shifts produce bleeding of touch data of column pixels into each other, and therefore result in an increase in the artificial noise floor, not related to thermal and quantization noise, but related to intersymbol interference (ISI). The problem is exacerbated by finite precision and high condition numbers of the inverse matrix multiplier. For lower speed signaling with gaps between Excitation matrix bits and for non-zero carrier frequency, the down conversion mixing that is common to the entire column significantly reduces the gain of the row signals with large phase shifts over the column, which degrades the thermal and quantization S/N


reasons – a distinction lawmakers on both sides of the issue pointed out Tuesday.

“If you didn’t want a baby anyway to start with, this doesn’t stop you from having an abortion for anything under 20 weeks,” Sen. Michael Young, R-Indianapolis, said.

Opponents of the bill have argued the proposed restrictions are unconstitutional. They’ve noted the U.S. Supreme Court has declined to consider overruling lower court decisions that found abortion restrictions early in a pregnancy were unconstitutional. States face restrictions in banning abortions before a fetus could survive outside the womb.

Under the legislation, a physician who performs an abortion could face disciplinary actions or civil liability for wrongful death if he or she knows the procedure is being done in violation of gender or fetal disability restrictions.

A woman could stillweird error :
failure(Swift.DecodingError.keyNotFound(table_view_api.FlightWebService.Response.(CodingKeys in _954486EAAC5BB7DDCEFC26E493D69F38).flights, Swift.DecodingError.Context(codingPath: [Foundation.(_JSONKey in _12768CA107A31EF2DCE034FD75B541C9)(stringValue: "Index 0", intValue: Optional(0))], debugDescription: "No value associated with key flights (\"flights\").", underlyingError: nil)))
Am I missing something?
Further more, I am making my webservice request with the proper auth header like:
var request = URLRequest(url: url)
    request.httpMethod = "GET"
    request.setValue("Basic YWFnZTQxNDAxMjgwODYyNDk3NWFiYWNhZjlhNjZjMDRlMWY6ODYyYTk0NTFhYjliNGY1M2EwZWJiOWI2ZWQ1ZjYwOGM=", forHTTPHeaderField: "Authorization")

func getFlightData(for airportCode: String, minutesBehind:String, minutesAhead:String, completion: ((Result<[Response]>) -> Void)?) {
    var urlComponents = URLComponents()
    urlComponents.scheme = "https"
    urlComponents.host = "api.qa.alaskaair.com"
    urlComponents.path = "/1/airports/"+airportCode+"/flights/flightInfo"
    urlComponents.queryItems = [
        URLQueryItem(name: "city", value: airportCode),
        URLQueryItem(name: "minutesBehind", value: minutesBehind),
        URLQueryItem(name:


//  (C) Copyright Artyom Beilis 2010.
//  Use, modification and distribution are subject to the
//  Boost Software License, Version 1.0. (See accompanying file
//  LICENSE_1_0.txt or copy at http://www.boost.org/LICENSE_1_0.txt)

#ifndef BOOST_CONFIG_PLATFORM_VMS_HPP
#define BOOST_CONFIG_PLATFORM_VMS_HPP

#define BOOST_PLATFORM "OpenVMS"

#undef  BOOST_HAS_STDINT_H
#define BOOST_HAS_UNISTD_H
#define BOOST_HAS_NL_TYPES_H
#define BOOST_HAS_GETTIMEOFDAY
#define BOOST_HAS_DIRENT_H
#define BOOST_HAS_PTHREADS
#define BOOST_HAS_NANOSLEEP
#define BOOST_HAS_CLOCK_GETTIME
#define BOOST_HAS_PTHREAD_MUTEXATTR_SETTYPE
#define BOOST_HAS_LOG1P
#define BOOST_HAS_EXPM1
#define BOOST_HAS_THREADS
#undef  BOOST_HAS_SCHED_YIELD

#endif
symmetric spacetime, if $\vec \lambda$ is a Killing vector field tangent to the axis of symmetry for all $q\in W_2$, then

$[\vec \xi,\vec \lambda]=0.$

\[teo:5.2\]

In an axisymmetric spacetime, let $\vec \lambda$ be a Killing vector field which does not commute with $\vec \xi$. If at some point $q$ of the axis $\vec \lambda|_q$ is not normal to $W_2$, then there always exists another Killing vector field given by $\vec \lambda+[[\vec \lambda,\vec \xi],\vec \xi]$ that commutes with $\vec
\xi$, and is therefore tangent to the axis.\[teo:prop5.3\]

It should be noticed that all the results above apply also to conformal Killing vector fields [@maseaxconf; @Marctesi].

Let us next consider the definition of cylindrical symmetry. In addition to the existence of two spacelike Killing vector fields, $\vec \xi$ and $\vec \eta$, one of which, say $\vec


case I, the Ricci tensor is of the Segre type $\{(1,1)11\}$ or some degeneracy thereof, and the Weyl tensor is type $D$.

Analogously to the previous case, we can put $A=0$ without loss of generality. In this case, however, equations (\[eq:sint\]) imply $d=0$, which leads to the Abelian case, thus no timelike integrable Killing vector exists in this group. As a matter of fact, what we have just proven is slightly more general than this; we summarize the results in the following

Given a $G_3$ on $T_3$ group of Bianchi type II having an Abelian $G_2$ subgroup acting orthogonally transitively and containing an axial Killing vector, then the only integrable Killing vectors in this group belong to the subgroup $G_{2}$.

This result can also be obtained for a conformal group $C_3$containing a $G_2$.

The definition of stationary (or static) cylindrically symmetric spacetimes has been based on that for cylindrically symmetric spacetimes. If, on the other hand, we had started with the usual definition of stationary axisymmetric spacetimes [@KRAM], we could have imposed that the timelike Killing vector $\stat$ and the axial Killing vector $\vec \xi$ generate a $G_2$ on $T_2$ group acting orthogonally transitively (for non-convective rotating fluids [@papapetrou; @kundttrump], see for instance [@senorot]), and the allowed Lie algebra structures would then be those four previously discussed. Nevertheless, it can be shown that the imposition of orthogonal transitivity on the orbits generated by $\stat$ and $\vec \xi$ gives no further restriction in the [*static*]{} non-Abelian cases. The conditions =0, =0 \[eq:lastassum\] applied to each of the algebraic cases give


Tag Team Championship to Akino and Kaho Kobayashi in their fourth defense on June 25, 2017. On July 15, Shida and Syuri lost the Sendai Girls World Tag Team Championship to Cassandra Miyagi and Dash Chisako also in their fourth defense. In November, Shida returned to Shimmer Women Athletes, unsuccessfully challenging Mercedes Martinez for the Shimmer Championship on Volume 97.

All Elite Wrestling (2019-present)
On May 25, 2019, Shida made her debut for All Elite Wrestling, competing in the six women tag-team match at Double or Nothing. On August 31 at All Out, Shida was defeated by Riho.

Acting career

Filmography
2008:
2009:
2009:
2009:
2010:
2011:
2014:

Television
2008–2009:
2009:
2009:
2009: S-Arena
2010:
2011:
2011:
2012:

Other media
In 2008, the cast of Muscle Venus recorded a song titled , which was released as a singlehave a lot to improve on your website, marketing & UX.

Here's what I think: 1\. I only saw the "Feedback" widget AFTER seing the
movie. Either make it bigger or point a big arrow on it. 2\. I'd love if I
could adnotate highlights with some text. 3\. Your prices are too close
together, so the cheapest one still seems expensive. Try testing with 2x price
for Start up and 10x for enterprise.

BTW, I am using [http://www.criticue.com](http://www.criticue.com) to get
feedback on my websites, you can use that too.

Good luck with the project!

------
bentona
This might seem insignificant, but it's a good example of how you could
improve your marketing with little tweaks.

On your pricing page, the 'Personal' plan has one check mark and three red
"X"s. Why have the Xs at all? It's not that your personal


Bishop Anatolius was born Vladimir Aleksandrovich Aksenov on 22 November 1958 in Pereslavl-Zalesk, USSR. In 1981 he entered the Moscow Theological Seminary and in 1985 the Moscow Theological Academy, graduating in 1989. In the meantime he was tonsured in June 1987 and subsequently ordained to the deaconate and priesthood. In 1990 Fr. Anatolius was elevated to the rank of igumen and in 1995 to the rank of archimandrite.

+

Bishop Anatolius was born Vladimir Aleksandrovich Aksenov on [[November 22]], 1958 in Pereslavl-Zalesk, USSR. In 1981, he entered the [[Moscow Theological Academy and Seminary|Moscow Theological Seminary]] and, in 1985, the [[Moscow Theological Academy and Seminary|Moscow Theological Academy]], graduating in 1989. In the meantime he was [[tonsure]]d in June 1987 and subsequently [[ordination|ordained]] to the [[deacon]]ate and [[priest]]hood. In 1990, Fr. Anatoliusdiv(
  withMathJax(),
  h3(style = "color: #337ab7;", "What is posterior predictive checking?"),
  p(
    strong("The idea behind posterior predictive checking is simple:")
  ),
  p(em("If our model is a good fit then we should be able to use it to generate")),
  p(em("data that looks a lot like the data we observed.")),
  br(),
  p(
    "To generate this 'replicated' data we use the",
    em("posterior predictive distribution")
  ),
  span(
    style = "color: #337ab7; font-face: bold;",
    withMathJax(
      "$$ p(y^{rep} | y )  = \\int p(y^{rep} | \\theta) p(\\theta | y ) d \\theta,$$"
    )
  ),
  p(


congratulations. But planning is not done yet,” Gosnell warns. Be careful with your money — you’ll likely need to spread it out over the next 20-30 years. It’s better for your savings to outlast you than the other way around. “Your retirement savings will need to support you through these years, so although your portfolio’s conservative, it still needs a significant growth component, namely in stocks,” Gosnell advises.

If you’ve entered this age and are still concerned you’ll outlive your savings, you do have options: Consider buying an annuity to provide a guaranteed level of income for the remainder of your life, or if you have significant equity in your home, look into a reverse mortgage to provide regular income. But Gosnell warns, “If you’re in a position tofleets, especially in the context of the Red vs Blue eternal war.

16:30 (15:30 EVE Time) – 3rd Party Developer Panel

Check out this panel for questions and answers on all things third party development with CCP Bartender and CCP Fozzie.

17:30 (16:30 EVE Time) – The Agency & Activity Tracker Panel

Come along to this panel for more information on the Activity Tracker and The Agency, as well as a sneak peak of some updates that are coming soon.

21:00 – Drinks @ EVEsterdam

The first night of EVEsterdam will see devs and players relax at the EVEsterdam venue, with an open bar for several hours before many attendees no doubt head into town for more shenanigans and coffee!

(Click to enlarge!)

Day Two – Sunday March 24th

10:00 (09:00 EVE Time) – Doors Open

Breakfast? Recovering


all the devs attending EVEsterdam who're brave enough to answer questions about their favorite flavor of ice cream, most embarassing EVE moment or most loathed ship. What could possibly go wrong?

15:30 (14:30 EVE Time) – EVEsterdam Invasion Tournament Series Final Stages

These two hours will be reseved for the final stages of the Invasion Tournament Series at EVEsterdam, where a lucky pair of pilots will be victorious, winning a trip to Fanfest 2020!

17:30 (16:30 EVE Time) – EVEsterdam Closing Ceremony

The saddest part of any event is always the closing ceremony. Come join CCP Falcon, CCP Guard and CCP Dopamine as we look back on EVEsterdam and cry about having to head back to a barren rock in the North Atlantic.

21:00 – The Friendship Cruise

Drinks, hundreds of Capsuleers. A boat.again be partnering with Streamfleet, an amazing group of capsuleers from across the globe who’ll be assisting with the hosting of our livestreaming efforts for the whole of the EVE World Tour this year.

The whole EVEsterdam presentation and panel schedule will be streamed live on the CCP twitch channel, with additional content and interviews during breaks for lunch at the EVEsterdam venue.

Stay tuned to the CCP twitch channel for more details on the EVEsterdam livestream and check out the schedule below!

The Friendship Cruise

Hundreds of capsuleers. Many drinks. One boat. What could possibly go wrong?

To round out EVEsterdam we’ll be taking all attendees who’d like to come along on a Friendship Cruise on the majestic waters of Amsterdam.

We’ll board the Friendship starting at 20:15 at Pier 14 beside Amsterdam


present time, however, when traffic has greatly increased, the parking conditions must be such that there is no wasted space in the vicinity of the terminals and such that debarkation of the passengers takes place as quickly as possible.
To this end, efforts are now made to bring the aircraft alongside the terminals with an accuracy such that their door or doors come exactly opposite the opening of the pre-gangways with concertina walls dependant on fixed buildings. This stopping accuracy is obtained by optically guiding the aircraft whereby a barrier is provided comprising a stop carrying a guide pattern and against which the pilot must bring the windscreen of the cabin of his aircraft.
The problem with this type of guiding is the positioning of the stop. In fact, itsrescue Yara. One of them mocks him and beats him, but despite falling down several times, he keeps standing up, and he finally gets the upper hand.

The ironborn respects him for this, and he tells them that you are not doing this for me but for the sake of my sister. And they all agree and choose to follow his command.

Back at Winterfell, Sansa summons Arya to the great hall.

Behind the main table at the Great Hall are Sansa and Bran, and the room is filled with Northern guards and knights of the Vale.

Arya arrives escorted by two guards and she asks Sansa if she is ready to do this. She says she is, Sansa then turns to Lord Baelish and accuses him of treason and murder. She


the Indiana Railroad

Company (Indiana Railroad). Given the frequency of the patrols he conducted in the area,

Officer Van Horn suspected that the Dodge truck was not meant to be there. Based on that,

Officer Van Horn pulled into the property, and when he approached the truck to locate the

driver, there was no one in the vehicle. Looking into the bed of the truck, Officer Van

Horn saw four buckets filled with scrap metal. He also noticed a crate sitting next to some

nearby train cars, which had been filled with more scrap metal. A short time later, Officer

Van Horn found Elkins and another man hiding behind the train cars. Upon speaking to

Elkins and the other male, it occurred to Officer Van Horn that the men did not have

    See Payton v. State, 818 N.E.2d 493, 498 (Ind. Ct. App. 2004),

trans. denied.    Thus, when making this determination, we may look to any factors

appearing in the record. Stokes v. State, 947 N.E.2d 1033, 1038 (Ind. Ct. App. 2011), trans.

denied. Elkins bears the burden to “persuade the appellate court that his sentence has met

this inappropriate standard of review.” Childress v. State, 848 N.E.2d 1073, 1080 (Ind.

2006).

                                               3
       The determination of whether we regard a


brief, Elkins

attempts to minimize the seriousness of the offense by stating that he “simply went to the

                                              4
railroad tracks [to collect] rusted nuts[,] bolts and other metals [on] the ground [] not in

use. (Appellant’s Br. p. 4). We find Elkins argument that the scrap metal was worthless

to be meritless because the record reveals that he intended to sell the scrap metal to a local

scrap yard. We also reject Elkins’ explanation that his “daughter was completely out of

diapers” and he needed the money from//
//  UIImage+Extension.swift
//  YLBaseChat
//
//  Created by yl on 17/5/24.
//  Copyright © 2017年 yl. All rights reserved.
//

import Foundation
import UIKit

// MARK: - UIImage 拓展
extension UIImage {

    // yl_tag
    var yl_tag : String? {

        get {
            return accessibilityIdentifier
        }

        set(newVal) {
            accessibilityIdentifier = newVal
        }
    }

}


Conker the squirrel: hard-drinking, money-grabbing, but never foul-mouthed.No, in a nod to his innocent early life,he leaves the not-safe-for-work language to other people.Or scarecrows! Or classically trained cack monsters!Conker’s problem is that he’s hung over and lost in a worldfull

Shawty’s like a melodyShawty’s like a melodyShawty’s like a melodyShawty’s like a melodyRemember the first time we metYou was at the mall wit yo friendI was scared to approach yaBut then you came closerHopin’ you would give me a chanceWho

DAN: THE NAME OF THE GAME ISCALLED ROADBLOCKS.YOU WILL WANT TO PUT ON YOURLIST.THE ORKE STATE OFMIND,” PROGRAM IS BROUGHT TO YOUIN PART BY LOOKOUT RHODE ISLANDAND PECO COMFORT SOLUTIONS.DAN: PROFESSORHUMBLE HIS BACK.SHE’S GOING TO ONCE AGAINLAYOUTSOME REALLY INTERESTING WORDINGIDEAS

This is the Cody trust shot.Yippee.Dude Perfect.What’s up, guys? We’re DudePerfect.I’m Logan.World champion boomerang thrower.Let’s have some fun!Let’s turn the lights out.This one’s called the balloonerang.Very nice!Now over the years here, we’ve developed some targets with nice payoffs here

It’s been 40 years since the perfect 10.The first time in the history of the sport, a perfect 10.You’re just in awe, you want to replicate the exact same thingbut it is very difficult and that’s whyshe’s the only one

Saboteur is a 30 minute game for 3-10 players where you take the roles of dwarven minerssearching for gold.Use your cunning to subvert the saboteurs and collect the most gold to win the game!Keep your identity hidden in this game

NERF THIS!Do you guys remember Boo from Monsters Inc.?RAWWRYep, thi- this is her now.So, D.VA pilots her mech and on the mech,


4 days watching the Food Network. I am so excited to add a few more ingredients to my cooking and try some new recipes. I see how to make them healthier... I am not craving junk food... just different food. I am a little tired of the vegetables on this plan, though the protein I have been alright with... I am wanting to add back some beef into my life.

I do not know how being on the diet has effected my illness or getting well. I have tried to be smart about it. I have made sure to make a fruit serving an orange everyday for the Vitamin C. This illness has not effected my stomach as much as my throat and sinus. I have also had hot/** @file
*
*  Copyright (c) 2012-2017, ARM Limited. All rights reserved.
*
*  SPDX-License-Identifier: BSD-2-Clause-Patent
*
**/

#ifndef __ARM_MM_SVC_H__
#define __ARM_MM_SVC_H__

/*
 * SVC IDs to allow the MM secure partition to initialise itself, handle
 * delegated events and request the Secure partition manager to perform
 * privileged operations on its behalf.
 */
#define ARM_SVC_ID_SPM_VERSION_AARCH32             0x84000060
#define ARM_SVC_ID_SP_EVENT_COMPLETE_AARCH64       0xC4000061
#define ARM_SVC_ID_SP_GET_MEM_ATTRIBUTES_AARCH64   0xC4000064
#define ARM_SVC_ID_SP_SET_MEM_ATTRIBUTES_AARCH64   0xC4000065

#define SET_MEM_ATTR_DATA_PERM_MASK       0x3
#define SET_MEM_ATTR_DATA_PERM_SHIFT        0
#define SET_MEM_ATTR_DATA_PERM_NO_ACCESS    0
#define SET_MEM_ATTR_DATA_PERM_RW           1
#define SET_MEM_ATTR_DATA_PERM_RO           3

#define SET_MEM_ATTR_CODE_PERM_MASK   0x1
#define SET_MEM_ATTR_CODE_PERM_SHIFT


F.3d 1338, 1346 (Fed.Cir.2006) (citing Schering Corp. v. Geneva Pharm., 339 F.3d 1373, 1379 (Fed.Cir.2003)); see Impax Labs., Inc. v. Aventis Pharm. Inc., 468 F.3d 1366, 1380 (Fed.Cir.2006).
Independent Claim 1 of the '060 Patent discloses:
A plunger lift for a well producing through a production string communicating with a hydrocarbon formation, comprising a free piston having at least *713 two sections, movable independently downwardly in the well, the sections comprising a lower component and a sleeve providing a seating surface for receiving the lower component so the lower component and sleeve join together in the well for pushing liquid, above the piston, upwardly and a catcher assembly on the well at the surface comprising a housing, a separator rod in the housing for receiving the sleeve thereon and dislodgingbetween the issuance of the '513 Patent in 1959 and the development in 2002 of the two-piece plunger lift system covered by the '060 Patent. Mega Lift has failed to present clear and convincing evidence to support its obviousness defense. As a result, MGM is entitled to summary judgment on the defense and Mega Lift's motion for summary judgment on the issue is denied.
C. On-Sale Bar and Improper Joinder of Inventors [Doc. # 110]
The parties have both moved for summary judgment on Mega Lift's claims that the '060 Patent is invalid because the device was offered for sale more than one year prior to the filing date of the patent application and because MGM failed to name Dan Casey as an inventor.[4]
On-Sale Bar.  A person is not


construed the term in claim 22 "holding the sleeve in the decoupler" by passing formation contents upwardly to mean "holding the sleeve on the rod in the container or casing." See id. at 15. At the hearing in this case on a spoliation issue, Mega Lift's president testified generally that the Mega Lift devices hold the sleeve in the housing not by passing formation contents upwardly, but by the weight of fluid molecules, striking the relatively flat bottom, of the sleeve. The Court finds that the interests of justice favor allowing Mega Lift an opportunity to explain this theory more fully.
The infringement issues in this case are more properly decided after a full presentation of the evidence, subject to the Court's prior rulings excluding certain evidence. This willDr. Alworth, whose report and testimony has been excluded by the Court.
[4]  MGM also moved for summary judgment on Mega Lift's arguments that the '060 Patent is invalid because MGM failed to satisfy the written description requirements of 35 U.S.C. § 112, because the device covered by the '060 Patent is possibly inoperative, and because MGM has abandoned the invention. Mega Lift responds that it "has never asserted, any of [these] defenses." See Response [Doc. # 127], p. 12. Consequently, to the extent Mega Lift's pleadings can be construed to raise these issues, the defenses are withdrawn and MGM's motion for summary judgment on them is moot.
[5]  To the extent Mega Lift relies on Dr. Alworth's report for this argument, that evidence has been excluded.
[6]


is in the areas of public finance, tax policy, energy economics, and environmental economics.  According to IDEAS/REPEC, Metcalf ranks in the top three percent of economists worldwide on the basis of research.  He has over 7200 citations in Google Scholar and an h-index of 39. Metcalf has published over 130 papers, book chapters, and other publications including 3 edited books.  His newest book, Paying for Pollution: Why a Carbon Tax is Good for America, was published by Oxford University Press at the end of 2018.

Tax Policy
Metcalf's early research focused on the fiscal interaction between federal tax policy and state and local government budgets.  An early paper with Martin Feldstein challenged the view that eliminating the federal deduction for state and local taxes wouldPolymorphonuclear leukocytes regulate the plasminogen-activating system of cultured endothelial cells.
Exposure of bovine pulmonary artery endothelial cells (BEC) to polymorphonuclear leukocytes (PMN) (1 x 10(6)/ml) stimulated by opsonized zymosan (OZ-PMN) decreased plasminogen activator (PA) activity in conditioned medium by as much as 98% as compared to controls. Unstimulated PMN (U-PMN) (1 x 10(6)/ml), after an initial enhancement, decreased PA activity 95%. Low concentrations of U-PMN and OZ-PMN enhanced and high concentrations depressed PA activity. The decline in PA activity was not associated with an increased endothelial cell injury. The suppression of PA activity by OZ-PMN was associated with a 7-fold increase in activity of PA inhibitor 1 (PAI-1). PMN did not affect PA after its secretion, suggesting that modulation of endothelial cells by PMN changes the net activities of


hypertension, while his eyesight has deteriorated from a lack of light and visual stimulation in his cell.

And then there is his mind. “It’s rough, you know,” Whitmore said. “You find yourself doing a lot of crazy stuff.”

In a letter to The Medill Justice Project, Whitmore described “human waste throwing” by inmates in solitary confinement, which is prompted by even small disagreements between prisoners who “want the lights on to read, write, study, and others [who] want it off so that they can sleep all day in the partially lighted cell.”

Sheila Whitmore, holding a picture of her brother Kenny, says she can barely see him through the partition when he is brought shackled into the visitor's room.

Studies note the effects of solitary on inmates, including gastrointestinal and cardiovascular problemsBill seeks to outlaw abortion on the grounds of disability

The House of Lords will debate abortion on grounds of disability, after the Conservative peer Lord Shinkwin introduced a bill on the subject.

Lord Shinkwin’s Abortion (Disability Equality) Bill was drawn 12th in the private members’ ballot, and was given its first reading on Wednesday. Introducing the bill, Lord Shinkwin said: “Discrimination on the grounds of disability after birth is outlawed. Yet today legal and lethal discrimination on the grounds of disability is allowed up to birth by law.”

The 1967 Abortion Act made abortion legal at any stage, if two doctors give the opinion that “that there is a substantial risk that if the child were born it would suffer from such physical or mental abnormalities as to be seriously


in modern warfare, has come at the expense of traditional intelligence gathering techniques, in essence “the tactical tool, technology… has trumped strategic analysis”, Felbab-Brown concludes.

The increase in advanced technologies has had other, less predictable impacts too. As organised crime actors have adopted advanced technologies in response to law enforcement agencies, they have also responded in the opposite way, by developing primitive technologies and methods to counter the advanced technologies used by law enforcement, according to Felbab-Brown. At the same time, society has adapted to criminal groups and violence in a similar way, by adopting its own ‘back-to-the-past’ response with, for example, anti-crime militias. The implication of this, Felbab-Brown warns, is deeply worrying as citizens’ militias “fundamentally weaken the rule of law and the authority and legitimacy of the1. Bush and Sproles are really close. With Sean Peyton back after his suspension, I look for Sproles to be used more in the offense.2. Gonzalez - Witten - Gronk(if healthy) - Davis - Rudolph3. Not really a super sleeper, but Robert Woods in Buffalo might be interesting...4. If you can't get one of the big 3...I'd aim for Andrew Luck.5. Charles - Rice - Richardson - Spiller - McCoy6. Selling. I'll buy Jacquizz Rodgers7. No.

1. Do I have to take one? I'd rather draft another position and see who is left2. Always Witten if he's available. You can always hope Davis has a healthy season with no legal issues, I always like Jared Cook3. The RB Dallas drafted is probably a good risk as a sleeper4. If


and overheard someone tell another marcher not to do anything out of hand in front of the children.”

“Outsiders might have come in with an agenda,” he said, “But does it matter?”

“Let’s not lose focus of the real injustice: A SWAT team raided an apartment last week and treated it like they were playing a video game,” he said.

“But these are real lives.”

Anyone who would have seen the raided apartment — which police have since said was used as a hub for an alleged drug ring — would have seen that the people living there were barely living at all, Lamour said

“There are social-economic conditions that force people to do certain things,” Lamour said. “Why not try to understand those instead?

“Would a raid like that one have happened inaround the URA5 gene has been examined in S. cerevisiae, K. lactis, C. albicans and Y. lipolytica. Sánchez and Domínguez, Yeast 18:807-813 (2001). In all four organisms, the URA5 gene and a gene which functions in the secretory pathway (the SEC65 gene) are arranged adjacent to one another and in the opposite relative orientation.
A selection system based on disrupting the URA3 gene in P. pastoris has recently been disclosed. U.S. Pat. No. 6,051,419. The methods described therein also provide “pop-in” (site-directed integration of the transforming DNA by gene addition) and “pop-out” (recombination between functional and nonfunctional genes resulting in the loss of one of these genes and the URA3 gene) in what is referred to as a “bidirectional selection process.” “Pop-in/pop-out” gene replacement using S. cerevisiae URA3 is


Job Hunters: Here's How You Can Stand Out From the Pack

If you’re looking for work, these seven clever tactics can make you a memorable candidate

by Nancy Collamer • Next Avenue

Photograph: Shutterstock.com

Though the economy is beginning to improve, many employers are overloaded with job applicants and extremely choosy about who they’ll hire. So if you want to land a position, you’ve got to find a way to stand out from the pack.

That’s especially true for anyone over 50, who often faces the added burden of being viewed by hiring managers as overpriced, overqualified or out of touch.

To answer that question, I turned to my colleagues in the career advice world — authors, coaches and job-search strategists — and asked for their recommendations. As you’ll soon learn, just making aSports Injuries to the Latissimus Dorsi and Teres Major.
Injuries to the latissimus dorsi and teres major muscles, while rare, are debilitating. They are seen in a variety of sports, although disproportionately in the throwing shoulder of baseball pitchers. There have been 25 case reports and 2 case series published on the nonoperative and operative management of these injuries. Latissimus dorsi and teres major muscle anatomy, function, and common injury patterns are well described in these case reports. Also well detailed are the typical patient presentation, physical examination, and imaging findings. Latissimus dorsi tendon injuries are sometimes treated operatively, whereas latissimus dorsi muscle belly or isolated teres major injuries are treated nonoperatively. Nonoperative treatment includes oral anti-inflammatories and shoulder physical therapy. A number of surgical patient positions, approaches, and


fixation constructs have been described, although 2 techniques of positioning and surgical approach are used most commonly. Fixation is most often performed with suture anchors. Return-to-play timing, shoulder strength, and healing on magnetic resonance imaging are variable. No standard of care currently exists for the treatment of latissimus dorsi or teres major injuries. If treating a patient with an injury to either muscle, the clinician should be familiar with accumulated experience as reported in the published literature.Q:

Maintaining session in Silverlight

I am creating a Silverlight with WCF connectivity. I would like to create and maintain a session after user login in Silverlight and do the following.

On successful login, create a session object and store session id, user id, user name, session status
On further calls with WCF, the session information needs to be passed from Silverlight to WCF

One solution would be to create a session object and pass it as parameter to all methods.
Is there any other way of passing the info in all web service calls without passing a member variable?
Something similar to persistent Session object in ASP.NET.

A:

Why would you want to pass the session information each time?
If you're using ASP.NET to host your WCF service in ASP compatibility mode, you can


Family Commission to offer support for this initiative as it reaches the parliamentary floor for a vote. They include:

Marelys Pérez Marcano: marelysperez@an.gob.ve

Flor Ríos florrios: @ an.gob.ve

Carmen Rodríguez Rauseo: carmenrodriguez @ an.gob.ve

Juan José Molina: juanmolina @ an.gob.ve

Diluvina Cabello: diluvinacabello @ an.gob.ve

Alberto Castellar: albertocastelar @ an.gob.ve

There are no specific details on when the bill might reach the floor for a vote.she said.

In addition, Ms. Keane is a music consultant. For a $50 fee, she will recommend similar artists based on a customer's current tastes. After that, customers can pay Ms. Keane to purchase CD's from an online music service, like Apple's iTunes Music Store. (For that service she charges $25 an hour, plus the cost of the songs, at 99 cents each.)

Her tastes range from indie rock to Bob Marley to Michael Jackson, but she acknowledges that she is still learning. "My edge is not that I'm an expert," she said. "It's more that it's my job, and I'm willing to do whatever research it takes."

Ms. Keane says most of her customers are in their 20's and 30's and work in the financial sector -- people who are


in both sexes \[[@B12-ijerph-17-02148]\]. Hence, it seems logical that women above 31 and men above 32 years should consider changing to Ironman in order to be able to achieve or preserve best results. In summary, this study's results go along with literature showing that swim performance in recreational Half Ironman athletes seems to be hardest to preserve; that run performance decline is a constant one; and that cycling performance can be preserved up to older age groups.

Conceptualization, K.J.; methodology, K.J. and C.V.S.; software, C.V.S. and E.V.; validation and formal analysis, C.V.S.; investigation, C.V.S.; resources, K.J. and E.V.; writing---original draft preparation, K.J., C.V.S., E.V., P.T.N., and B.K.; writing---review and editing, K.J., C.V.S., E.V., P.T.N., and B.K. All authors have read and agreed to the published version of the manuscript.

Thiscanon —

— but some are even under the misconception that Ramsay did not kill his father at all. In fact, they believe that Roose Bolton was poisoned by the Starks.

In fact, what many of us thought we saw — Ramsay stabbing his father Roose Bolton — was actually Ramsay holding his dying father, after he was poisoned by the cowardly Starks.

From Redditor E-Nezzer:

“Look at how Lord Ramsay held his father in his arms until his very last breath, hopelessly trying to help him anyway he could as Lord Roose slowly died by poison, murdered by his cowardly enemies. There’s no hidden knife, no treachery, just sadness and despair in Lord Ramsay’s eyes as he is forced to witness his father’s life be so unjustly taken. Don’t believe in


companies like EA. I was also once a professor teaching Masters of arts. Thanks to the success of the Non Dairy Diary, I am now a full time illustrator.

The non dairy is about the cute and fun stuff I like to do and create, and I hope you will enjoy reading it as much as I like to share.

About Copyrigths:

As a reminder, my pictures are NOT copyright free. What does it means?

Do as a rule as you would do with a picture in a magazine. You can print and cut and paste, have fun as you would with your copy of a magazine. But you would never take a magazine picture and sell it as yours , or put it on your website without asking. Please respect mya systematic review of the recent international literature (2007-present) to help improve our understanding about the interventions which appear to work and those which have been less successful in reducing hospital bed use.

Method {#s2}
======

We systematically searched the following databases: PubMed / Medline, PsycINFO, CINAHL, BioMed Central and Kings Fund library using the following search filters; older people/frail older people/elderly people/geriatrics and hospital admission rates/hospital length of stay/hospital bed use/early supported discharge/admission avoidance/intermediate care. Studies were limited to publications from the period 2007-present. A total of 514 studies were identified. Following a review of study abstracts, we excluded those which did not include older people or frail older people as the main target population, studies which only included older people with specific long-term conditions and studies of lower quality,