the countries attending were more concerned about planning an agenda against Venezuela than talk about tackling severe corruption problems plaguing the continent.

In the article, “The Distracted Summit,” referring to the VIII Summit of the Americas which took place on April 13 and 14, attended by all the right-wing Latin American leaders, Ugarteche, of the Institute of Economic Research of the Autonomous University of Mexico (UNAM), shed light on the summit’s destructive and divisive role in the region.

“In sum, the summit in Lima shows that half the hemisphere will recognize the Venezuelan elections and no half and that there is a problem of corruption that must be addressed,” the UNAM researcher concluded.

“Although large capitals are accomplices and promoters of corruption around the world, in Latin America it has also
864 So.2d 1252 (2004)
Chester HARRIS, Appellant,
v.
STATE of Florida, Appellee.
No. 5D02-2847.
District Court of Appeal of Florida, Fifth District.
January 30, 2004.
*1253 James B. Gibson, Public Defender and Susan A. Fagan, Assistant Public Defender, Daytona Beach, for Appellant.
Charles J. Crist, Jr., Attorney General, Tallahassee, and Timothy D. Wilson, Assistant Attorney General, Daytona Beach, for Appellee.
PALMER, J.
Chester Harris appeals his judgments and sentences which were entered by the trial court after a jury found Harris guilty of committing the crimes of battery, resisting an officer with violence, and criminal mischief. Harris challenges his judgments and sentences arguing, among other things, that the trial court erred in failing to conduct a competency hearing or issue an order finding him competent to stand trial. We agree and therefore reverse.
Rule 3.210(b) of the Florida Rules


evaluate. He is competent.
TRIAL COURT: On the issue of competency, I've reviewed these reports during his testimony, as well as during his trial. And the reports stand for themselves. We have a situation where two doctors say he's perfectly calm and capable of understanding what he did and competent, competent to stand trial. We have one doctor who says he's, for one reason or another, thought he was not competent. Under our rules, he is competent. That issue is not before us.
Under the circumstances of this case, which include the trial court's failure to consider or read the expert reports on Harris's competence until Harris was testifying at trial, the failure of the trial court to engage in a colloquy with Harris to determine his competence, the failurethat when an issue of competency is raised, the trial court may conduct its own investigation to determine whether reasonable grounds exist to believe that the defendant may be incompetent and whether the safeguards of rule 3.210 are warranted).
In closing, we recognize that since Harris's competence can not be determined retroactively, his convictions must be reversed and this cause remanded for a new trial contingent upon a determination that he is competent to stand trial. See Tingle v. State, 536 So.2d 202 (Fla.1988)(holding *1256 that a hearing to determine whether a defendant was competent at the time he was tried generally cannot be held retroactively).
Judgments and sentences REVERSED; cause REMANDED.
SAWAYA, C.J., and TORPY, J., concur.


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5. Messenger women bag – Carved in leather and accessorised with metal and canvas thisthe long-term haemodialysis catheter were positive at 24 hours with Gram-negative rods identified as *Ochrobactrum* spp. by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS; Bruker Microflex, Biotyper 3.1; Bruker Daltonics, Bremen, Germany) and *O. intermedium* by the reference laboratory by partial sequencing of the 16S ribosomal RNA gene. Repeat long-term haemodialysis catheter BC of samples taken 24 and 48 hours after admission and peripheral BC of samples taken 96 hours after admission remained positive for *Ochrobactrum* spp. The catheter was removed, and antibiotic therapy was switched to meropenem 1 g iv twice daily, to continue 48 hours after line removal. He improved and was discharged.

Two months later he again sought care for fever and shortness of breath. At examination he had pulmonary oedema with a raised C-reactive protein of


79 mg/L. BC of samples taken at admission grew *Ochrobactrum* spp. after 31 hours. On the basis of reference laboratory susceptibilities he was treated with meropenem 1 g iv twice daily and tigecycline 50 mg iv twice daily. Transthoracic echocardiography demonstrated a 1.32 cm^2^ right atrial vegetation. He developed sudden hypoxia, and computed tomographic pulmonary angiography revealed a right lung pulmonary embolus; he commenced anticoagulation therapy. Five days later he developed abdominal pain with amylase 267 U/L. Computed tomography confirmed pancreatitis. Because of this recognized tigecycline complication, tigecycline was switched to minocycline 100 mg iv twice daily. He was discharged 2 weeks later to complete 6 weeks of treatment with meropenem and minocycline. Repeated BC analyses have since been negative.

*Ochrobactrum* spp. are non-lactose-fermenting, Gram-negative rods that belong to the genus *Brucella.* The most commonGA synthesis deficient mutant z*mga3ox* was constructed and combined with exogenous GA~3~ and uniconazole (an inhibitor of GA biosynthesis, Ucz) for analyzing N uptake under LN and SN conditions. Moreover, GA-mediated NO~3~^−^ uptake was evaluated by using the non-invasive micro-test (NMT) and the ^15^N labeling technique. Furthermore, an RNA-seq assay was conducted to investigate the role of GAs in modulating N uptake at the transcript profiles. Thereby, the present study demonstrates the role of the GA in regulating the physiological responses in maize in correspondence to N supply.

2. Results {#sec2-ijms-21-01824}
==========

2.1. Characterization of zmga3ox Mutant in Maize {#sec2dot1-ijms-21-01824}
------------------------------------------------

The GA3ox enzymes participate in the synthesis of bioactive GAs and catalyze the conversion of GA~9~ to bioactive GA~4~ and GA~20~ to GA~1~ and GA~3~ ([Figure 1](#ijms-21-01824-f001){ref-type="fig"}a). In order to verify the


in the RNA-seq results ([Figure 7](#ijms-21-01824-f007){ref-type="fig"} and [Table S5](#app1-ijms-21-01824){ref-type="app"}). LN decreased the expression levels of *ZmNRT2.1* and *ZmNRT2.2* compared to SN at 60 and 108 h after treatment, and the expression levels of *ZmNRT2.1* and *ZmNRT2.2* in the *zmga3ox* plant were lower than those in the wild-type plant, except for 12 h after LN treatment ([Figure 7](#ijms-21-01824-f007){ref-type="fig"}a,b). Similar trends were observed in the expression of *ZmNPF6.4* under SN condition ([Figure 7](#ijms-21-01824-f007){ref-type="fig"}c). However, the expression levels of *ZmNPF7.3a* were upregulated by LN compared to that by SN, and the *zmga3ox* plant showed lower expression levels of *ZmNPF7.3a* than the wild-type plant after 60 and 108 h of the LN or SN treatments ([Figure 7](#ijms-21-01824-f007){ref-type="fig"}d). Inversely, LN significantly downregulated the expression levels of *ZmNPF6.3b* compared to SN, and the expressionA wellness approach.
There is a significant paradigm in the field of public mental health practice that encompasses a wellness approach. This paper will present a wellness approach by comparing it to the traditional medical model. A personal application of the wellness approach will be discussed.


Americans lack the power to control their financial futures. Financial success rarely happens by accident; it is typically the outcome of a journey that starts with education.

One of the obstacles to greater financial literacy is the so-called “Lake Wobegon effect.” In other words, we all consider ourselves above average, and based on that belief, it only follows that our financial understanding is above average. Unfortunately, this assumption has a flaw: it may discourage us from learning as much as we need in order to continue adapting to an ever-changing financial landscape.

The more informed we are, the more informed our financial decisions may become. Fortunately, we can consult a wide range of resources in pursuit of greater financial knowledge.

If you are committed to increasing your financial literacy, think aboutconfidence, he must quickly and aggressively correct clear procedural failings and hold facility directors responsible for abuses. And he doesn't have to wait for the inspector general's report to make obvious management and culture reforms.

This country has a moral obligation to provide the best care possible to those who have put their lives and health on the line. If Shinseki doesn't deliver changes soon, perhaps someone else should take the helm.


not he would return to United next season.

(Image: Dean Mouhtaropoulos)

“In a few weeks I'll be back in the field,” he said. “Where? Let's see.”

Following his surgery the Swede insisted he would 'come back even stronger' as he ruled out retirement.

Jose Mourinho has been heavily linked with a move for Atletico Madrid striker Antoine Griezmann this summer.

(Image: AFP)

After joining in with the post-match celebrations, the former Milan striker insisted that this was a win for the collective and he played his part.

“I had a different role. I supported the team, but what matters is that we won. That's the most important thing because this is a collective trophy.

Video Loading Video Unavailable Click to play Tap to play The video will start in 8 Cancel Play now

“You win and loseHeat and fire resistance Resistance to moisture, oil, grease, acids and alkalies Dimensional all year, your best bet would definitely be a solar water heater. The cost of a house to be built also largely depends on the cost of moccasin, whereas harmless water snake has a round eye pupil type. The ‘National Weather Service’ had seen and detected green blobs on their but if the asbestos fibers are concentrated in the room, it could cause serious health problems much later in life. Many real estate experts feel that a rise in the cost of construction between six to be too heavy to rise in the air if they are water-soaked.

If the person is convicted for drug abuse, for instance, he family, and two years later, his mother


the dinosaurs, who roamed freely across the southern plains of before eventually turning into the more recent boon to the Texan economy, oil. It's at this point I must declare a tiny, but personal revelation: after many years visiting and driving through the US, I have never before noticed the Sinclair Oil company, which operates filling stations in 22 states in the American heartland between the Mississippi River and California. The reason I mention this now, is that driving on Route 66 has brought me in to close proximity to Sinclair's logo - a brontosaurus.

At first thought, this seemed to me a little like McDonalds replacing its golden arches with the outline of a cow, or KFC removing Colonel Sanders' visage and putting an actual chicken in itswith fins, and before the fast food chains and franchises took over.

Food at the Midpoint Cafe is excellent, the coffee beats Starbucks into a crocked hat, the decor is authentically tasteful, and it has free WiFi and a gift shop. All in all, a stop you shouldn't miss.

There has been no shortage of the perfectly acceptable kitsch and nostalgic along the road since leaving Chicago. Some attractions have been accidental - run-down empty shells of businesses that, during the road's heyday, would have thrived.

Where, however, the attractions are still going strong is because they've been invested in. Which brings me to my resting place for the night, just 40 miles over the New Mexico border in Tucumcari.

In an area first populated 10,000 years ago, with dinosaurs abundant millions


Q:

unable to Delete a Document in a view

I am working on an Intranet Page with several views and forms, but one of my views gives me a headache. In all views i use:
<xp:button value="delete documents" id="button1" >
<xp:eventHandler event="onclick" submit="true" refreshMode="complete" immediate="true">
<xp:this.action>
    <xp:deleteSelectedDocuments view="viewPanel1"
        message="Do you really want to delete these documents?">
    </xp:deleteSelectedDocuments>
</xp:this.action></xp:eventHandler></xp:button>

to delete Selected Documents. But in one it does not work. Also when i try to use Code to delete them like:
var viewcontrol = getComponent("viewPanel1");
var ids = viewcontrol.getSelectedIds();

i dont get any Id's back from the view. The view is nothing special and i have full Access to the documents. Anyone who had this kind of trouble before?

A:

Found my problem: Had to remove immediate="true"from theissues debated on here every day.
Many on here want you to step forward into the shot, but
as you have discovered, it is better for the shot when you use the rt to left aspect for rotation.

OK thankfully the good feeling I had last time out is still there. Wasn't consciously thinking about anything except staying loose. Perhaps I could still emphasize the left arm pointing across to the ball a little more. The feeling is that the right leg initiates the kinetic chain, transferring from right to left, which really makes the core rotate much more naturally.

Please let me know what to work on. Feels like it's really improved. Footwork is a bit better, but still needs work. I kept the video a bit long to show consistency


causing your body to bend back.

Well, that pictogram was put in the book I copied it from as a model of perfect technique for students to emulate. The reference to "flipping" (not the best terminology), is there because that's what you have to do to hit a 1hb. Hoad's wrist action (it's really forearm action), may be more pronounced than some of todays players, but not all. It's not as pronounced as Federer's, Haas's or Gasquet's wrist action. It's just coming from a less low to high swing path. But, it's important to understand that that wrist action is EVERYTHING when hitting a 1hb. It is not merely ideal for emulating, it is essential. Without it, you can't hit a 1hb effectively, topspin or slice.

Click to expand...

This advicemovements)--is this better?

yes that is correct. if you hit like that and don't break your wrist you will get hard, biting spin on the ball instead of that weak old school spin your current stroke is producing haha. and you'll get more power from the leverage.

but your still going to produce a wimpy ball that i would eat up no problem.

you need to drive through the ball a little more. you have only brush there. no extension through the ball. and add some internal shoulder rotation. you have almost none.

all of your energy looks like it's focused on some point after the point of contact.
the energy has to be focused and explode on the contact point.

it looks like your main goal is to get the racquet to the


with it when I have to move to the left while hitting it. Both sides are serviceable, but no knifelike quality to them.

Will do! Yes it does look pretty good, I missed that early part. Will digest it all and see what comes out

Won't be on court for a few days, and I probably have too much forehand on the brain already. Perhaps we could talk about volleys for a while? This was after 45 minutes of nonstop forehands, so forgive my legs... the forehand side is more suspect. Sometimes I take it back too far, and I am having a particularly hard time with it when I have to move to the left while hitting it. Both sides are serviceable, but no knifelike quality to them.Justice to review the recent leaks and prosecute them.

“I am asking the Department of Justice and other relevant agencies to launch a complete review of this matter, and if appropriate, the culprit should be prosecuted to the fullest extent of the law,” he said.

Trump also specifically signaled support for the relationship between Britain and the United States.

“There is no relationship we cherish more than the special relationship between the United States and the United Kingdom,” he said.


publish magazines, catalogs, newspapers, books, and more online. Easily share your ...Read more

These presentations are classified and categorized, so you will always find everything clearly laid out and in context.
You are watching What is research?? presentation right now. We are staying up to date!#!/usr/bin/env python
# -*- coding: utf-8 -*-
#
# Copyright (C) 2010 Radim Rehurek <radimrehurek@seznam.cz>
# Licensed under the GNU LGPL v2.1 - http://www.gnu.org/licenses/lgpl.html

"""Random Projections (also known as Random Indexing).

For theoretical background on Random Projections, see [1]_.

Examples
--------
.. sourcecode:: pycon

    >>> from gensim.models import RpModel
    >>> from gensim.corpora import Dictionary
    >>> from gensim.test.utils import common_texts, temporary_file
    >>>
    >>> dictionary = Dictionary(common_texts)  # fit dictionary
    >>> corpus = [dictionary.doc2bow(text) for text in common_texts]  # convert texts to BoW format
    >>>
    >>> model = RpModel(corpus, id2word=dictionary)  # fit model
    >>> result = model[corpus[3]]  # apply model to document, result is vector in BoW format


short time windows. It may also meet the privacy protection requirements.
Drop samples with Voice Activity Detection
While recording, consider segments of 1-60 seconds. Run a standard Voice Activity Detection (VAD) algorithm on each of them. If voice is detected, discard the entire segment. Need to use a low threshold for the VAD to get a low amount of false negatives (sample actually has speech).
Sampling only when the VAD does not trigger may introduce bias in the data. For instance if there is humans talk at certain times of day. Or if some birdsong is confused as human voice by the VAD.

The first one on our Aragon Nest Team Interviews is That Planning Suite who are working on an open source incentivization app.

With this series, we want to bring forth the teams that have received a grant and funding from the Aragon Nest grants program. That Planning Suite was the first team accepted into the program and we're all thrilled to see their suite of apps becoming a part of the Aragon ecosystem.

Hello Yalda & team, great to have you as a Nest eaglet!

Could you tell us about your team and what made you come together?

Our team is composed of members of Space Decentral and Giveth. Yalda of Space Decentral began contributing to Giveth early in the year via the Bright ID app, and that’s where she got to


apps we are building, which is why I described them above. Right now we are finalizing Range Voting & Allocations, and in the middle of development for the Projects and Address Book apps.

I can't wait to use the Planning Suite to develop the Planning Suite - especially the ability to collect non-transferable tokens by completing tasks. I'm also looking forward to getting some user feedback once some of the apps are on testnet.

Quazia: Really excited to work on the Rewards elements, getting more intelligent dividend tokens that work out of the box will undoubtedly have some interesting use cases.

Which other projects in the Ethereum space are you most excited about, and why?

Yalda: We definitely have a bias to projects funded via Nest or building on Aragon such asPoker.

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then adding more threads is a good idea.

If the jobs are not CPU bound then adding more threads allows the CPU to do work when it would otherwise be idle, waiting for network or disk.
If there are idle CPUs then adding more threads allows those CPUs to be scheduled.
If partially-computed results are useful then adding more threads improves the situation because there are more opportunities for clients to consume partially-computed results. In our second scenario, for instance, the clients of both jobs are getting partial results every 200 milliseconds, which is fair.

A:

Most of the comments you have are correct, but I'll throw my two cents out as well (and list the comments in here):
Jonesy: "threading is most efficient in multi core environments" -> Yes, but thisinspected at any time?
boot.user=> @myapp.server/server-state

yields an error. (...no such var...)
When trying the same thing from within an emacs cider nrepl connection, this previous attempt always shows up the initial value of the atom: {:n 0}

UPDATE
Here are the exact steps I do when using emacs/cider:

cd projectdir
start emacs
cider-jack-in
(boot (dev))
Ctrl+C+C (in order to get a prompt again.)
Then Testing with curl: getting responses + inside emacs updated atom is logged: {:n 1} .. {:n 2} ..
Then, in the repl: (require 'myapp.server), takes a while: nil.
finally: @myapp.server/state --> however: {:n 0}

A:

Your (...no such var...) error probably happens because you haven't require the myapp.server namespace. Attempts to see updates happening to your atom in CIDER REPL fail probably because your ring app runs in another JVM process than your REPL so the REPL


hours (group 1) and those requiring VMI after more than 24 hours of support with NIV (group 2).

Results {#Sec4}
=======

49 patients, of whom 42 required VMI were included. 35 belonged to group 1, and 7 patients to group 2. We observed that group 1 patients have a significantly higher APACHE II \[28 (22-34) vs 17 (16-23); p = 0.04\] and more situations of septic shock \[20 (57.1) vs. 1 (14.3); p = 0.005\]. No significant differences in the development of organ failure (renal, hepatic, hematologic), the use of supportive therapies, or in-hospital mortality (30, 85.7% vs. 6, 85.7%; p = 1) were found.

Conclusions {#Sec5}
===========

In our series, the failure of NIV carries the same mortality as the VMI in the early hours of ICU admission.
1. Field of the Invention
The present invention relates to a convertible folding box with which a lettering suitable for redispatching is already integrated into the folding box and the folding box is convertible into a redispatch packaging.
2. Description of the Prior Art
Folding boxes made of cardboard or similar materials are widely employed as packaging, for protecting, presenting, and shipping products. In many cases, a product can be presented and locked in position within its box by means of one or more inset devices (made of styrofoam, cardboard, or other suitable material) inserted into the box. As used herein, "folding box" refers to boxes that can be initially stacked and handled in a collapsed configuration, which is relatively flat (usually with a thickness of only 1 or 2 sheets


of cardboard). Such boxes are usually manufactured and then bundled together (while lying flat) in large bundles (such as sets of 20, 50, or 100), for shipping to the company that wants to use the boxes to hold its products. The user company then assembles the boxes into a product-holding configuration, and inserts its products into the boxes. If desired, such boxes can be secured in a product-holding position by means such as staples, glue, or adhesive tape, at one or more locations, or by means such as inserting protruding tabs into accommodating slots.
Large quantities of folding box packaging are disposed of by customers after buying products, but that is not always the case. For example, many products (especially high-value products, such as electronic equipment) require purchasers toitems such as company records or medical samples; and (3) transporting items (such as used or defective merchandise, empty bottles, medical samples, etc.) to a store, warehouse, laboratory, or other facility. These are merely examples; the particular method of redispatching an item to a new location is not crucial to this invention.
Various boxes designed for redispatching have been previously created, but all items known in the prior art suffer from one or more drawbacks. For example, German patent DE 43 13 108 A1 discloses a convertible folding box with a first and a second lid, for closure of the box. The first lid is provided with a first address for dispatching, and the second lid is provided with a second address for redispatching. In use, this box suffers


The present invention relates to liquid crystalline polymers, and in particular to liquid crystalline polymer films used in the formation of multi-layer circuits.
Liquid crystalline polymer (LCP) films are useful in laminates and printed circuits because they typically exhibit low moisture absorption, excellent heat resistance, and good high frequency properties. Despite these advantages, LCP films have not gained wide acceptance and use because they are difficult to laminate consistently. This is due at least in part because the coefficient of thermal expansion (CTE) and the dimensional stability of LCPs are very sensitive to temperature, and the flow properties of LCPs are sensitive to pressure. Additionally, the melt temperature of the LCP film can be altered upon exposure to high temperatures. To achieve uniform lamination of LCP films, lamination equipmentout and made a throwing error in the game — a low throw that Mark Teixeira would have picked cleanly 99 percent of the time — he was clearly moving well as he beat out a bunt single in the fifth inning and went first to third on an error.

He said of his decision to bunt in his final at bat, “They were playing back and we needed baserunners. You come here and you still to play the game the right way.” Typical Jeter play.

“I just want to thank him,” said Thunder manager Tony Franklin, a 60-year-old career minor-leaguer. “Having Derek here for two days, so our guys could see the way he goes about his daily business, the love he has for the game, it’s been very


major roads 2% of Spain Chicago has about 2.7 million people, making it about 3x bigger 1% of the U.S. Lyon has a population of almost 500,000 1% of France Constitutional monarchycrowned republicprime minister- head of government and excercises political power voting-18 women and menknown for being relatively stablecorruption not a problem former republicpeaceful transition to democracycivil war 1936-39 between loyalists and nationalists boundaries are geographicmountains and bottleneckelevation change between portugal and spain majority religion- Catholicfreedom of religion guaranteedunique foods- paellas and tapas Spain has a mixed economy as does the U.S. and other developed countries. A mixed economy has stock, import and trade, and revenue from taxation of its residents. Living in Spain Per Capita GDP Spain-$30,400

The GDP in Spain and surrounding countries is around the same.the landmasses come together, they create giant disasters, killing countless people in the process. Will Jackson, a.k.a. Braceface, be able to be the hero he wants people to see, or will he fall short and be the bully he's been recently known to be?

Countless middle graders will love this book and the rest of its companions in the series! It was fun, humorous, full of adventure, and an overall good read. There were two aspects that I really enjoyed in this book. The first one was how the six main children in this book were all unique and diverse. This created a great multicultural arrangement and an unforgettable ride for the reader. The second reason then tied into a theme that struck me multiple times while reading Buckley's


excellent book: It's okay to be different. I think that this is a great message that so many people and children need to read more of. Sure, the bullying in this book was brief, but it was well addressed. When Jackson hurt Duncan, Ruby, Heathcliff, Julio, and Matilda, they were just some nerds who blended in with all of the rest of his school. However, when he spent time with them, he noticed that what made them nerds was unique to their personalities yet it also didn't define them. People are so much more than what they seem. This was what he learned after joining N.E.R.D.S. Jackson also learned that he didn't need to be a bully to be cool or to attract real friends. He just neededFeature

Made of easy-wipe polyester, the organizer attaches to the stroller's handlebars so toys, stuffed animals, and other kiddie necessities are at your fingertips.

Dimensions: 36*12*13 cm

Use as baby buggy stroller organizer bag for storing diapers, baby bottle, a spare suit, tissue, thermos, snacks, toys, and more. Also use as handbag insert organizer and keep your mobile, keys, purse, make-up and other essential items organised and within easy reach.

Compatible with most stroller/pram/pushchair/buggy and with two elcro straps allows you to hold it tight in position and remove it quickly and easily

Product Description

The Stroller organizer is functionally designed for organizing drinks, diapers, and personal on-the-go necessities. It features 2 deep drink pockets and a zippered security pocket for a wallet, cell phone, camera or other valuables. A bonus features of the


 // Compilation error
byte c = (byte) i;  // OK

Under normal circumstances, you cannot assign an int to a byte without a cast.  However, if the value are assigning is a literal, and the literal value is within the range of the target type, the Java language permits the assignment without a cast.  The literal's value is implicitly narrowed from int to byte.
This is described in JLS §5.2 which defines the conversions that may be performed in an assignment:

"A narrowing primitive conversion may be used if the type of the variable is byte, short, or char, and the value of the constant expression is representable in the type of the variable."

And as you can see, this doesn't just apply to literals.  It applies toand college campuses has been of increasing attention recently and as a result, many schools have begun searching for ways to better support the mental well-being of their student body. One initiative that has arisen out of this is #MyDefinition, a poster and social media campaign that originated at UNB Fredericton.

Through the use of photographs and personal stories from students, the campaign strives to demonstrate the wide spectrum of mental health disorders, in addition to increasing awareness of mental health on campus, and encouraging students to seek support and help by combating stigma and letting students know they are not alone. Most especially, the project also emphasizes the message that though "mental health is a part of me, it does not define me".

"Recovery isn’t black and white. It’s


and eat exclusively from food options in the building. You rarely see the sun, your mother currently has to take care of your cat for you, and you are home so infrequently you cancelled your Internet and cable."

Sound familiar? For many new physicians and residents, this is the road working in the medical profession can frequently take. However, the problem of such a scenario is that it is the perfect environment to become overwhelmed, stressed, and eventually burnt out and becoming depressed, or even suicidal.

On the bright side, many residency programs and medical facilities are working hard to focus on resident wellness and put in place services to support their learners and staff. However, as this article points out, often these supports tend to be offered at theAlbumin, bilirubin, and activated carbon: new edges of an old triangle.
The problem of interaction of human serum albumin (HSA), unconjugated bilirubin (UB) and high porosity activated HSGD carbons is investigated in this study. The decrease of UB to HSA molecular ratio by more than 300 times was demonstrated while the batch experiments in HSA-UB admixtures after contact with HSGD. HSGD carbons express extremely high activity for the removal of UB from HSA containing solutions (more than 100 mg of UB per 1 g of activated carbon). Ex-tempore albumin-coating of carbon surface decreases adsorbent capacity by bilirubin on 21%. At the same time ex-tempore albumin-coating of HSGD carbon surface as well as blood citratization prevent platelet and leukocytes loss and clotting inside of the column. Pharmacopoeia solution of HSA


down to the Bowling Alley on a Friday night was the end of the world, your parents were out to ruin your life and clearly wanted you to have no social life and they hated you. That was what your whole world was like then.”

Saoirse said Erin was great fun to play. “What I most loved about Erin when I read it was these ambitions, these dreams she has of being a writer and her relationship with her mum and dad. Your mum and dad in Derry would say, ‘You’re a dose.’ I wanted to be an actor when I was young and my parents definitely supported it, but they made sure I wasn’t running off on a high horse at times. I was definitely told to ‘wiseopen a file and obtain an hexadecimal string, so in this case all I need is to use "this way", if it is there).
Related question: passing hexadecimal data to sql server
UPDATE: after reading the comments I think it is needed to add more information here. The reason why I try to use a T-SQL text command to send the binary data to the stored procedure is that in this way I remove some overhead to the server: the stored prcoedure recieves the binary data and writes it to a file (this is my final goal). If I use a DAC component I will be able to easily send the biray data to the server, but in that case I need to use a temp table to store the


Meaning & Origins

Altered spelling of German Bingemann, probably a habitational name for someone from any of the various places called Bingen or Bingum, or a topographic name from Binge ‘trench’, applied also to a kettle-shaped depression or a collapsed shaft in a mine (see Bingel).end a “tale of two cities,” extreme redistribution schemes eventually collapse. They never succeed because they conflict with human DNA.

Unfortunately, they often do tremendous damage before they perish. Taking liberty from individuals and concentrating power in the hands of bureaucrats inevitably results in stunted growth, lost opportunity and human misery. The powder keg grows as freedom is squashed.

That is the consequence of false prophets, even when they have good intentions. Out of ignorance and arrogance, they do more harm than good.

Meanwhile, the Jets, like all people everywhere, must keep striving. They might never win another Super Bowl, but that’s life, and there’s nothing inherently unfair about unequal results.

Kerry’d away with power

Each time I see a story about another John Kerry fixation, I know that somewhere, a village is


charity game has always been a refuge from the tense battles inside the Capitol,” Swalwell told Fox News. “To see players under attack is sickening.”

President Trump condemned the shooting Wednesday morning saying, "Many lives would have been lost if not for the heroic actions of the two Capitol Police officers who took down the gunman despite sustaining gunshot wounds."

Fox News' Chad Pergram contributed to this report.40 Tips For Organizing Your Closet Like A Pro

forty Guidelines For Organizing Your Closet Like A Pro

Have you ever wondered how to get your closet hunting like those beautiful photos we see in magazines or the glimpses we get of celeb wardrobes on tv? Effectively, with our assist you’ll be flaunting your garments, footwear and add-ons in a way that will have every buddy, loved ones member and neighbor in awe. Check out out these forty ideas for organizing your closet like a professional and begin re-organizing your own area today!

Empty it

See in gallery

First items initial, empty out the total closet. Even if it appears like a department keep exploded in your bedroom, when organizing like a professional you need to commence from scratch – a good clean


is plastic containers, baskets and far more the important here is to not get before you’ve looked by way of what you are maintaining.

Go By Season

View in gallery

One particular way to organize your garments back inside the closet is to go by season, even if you have to switch out blouses and bottoms according to the time of yr – bringing them to the front of the pack for simple grabbing.

Shade Code

View in gallery

And to break down the organizing even far more, colour code your things. This will make it so much less difficult to discover specific pieces you might have in mind and also generate outfits with no tearing every thing off the hangers.

Light to Dark

See in gallery

If you are really wanting to make your closet appearis to compared with a value of 15star-formation and the theoretically indicated value of $f^\prime \cong 1/3 (f \cong 2/3) $ for low-mass star-formation (Tomisaka 1998, Shu et al 1999).

Summary and Conclusions
=======================

Combining a large archive of 2-D radiative transfer models (Robitaille et al 2006, 2007) and SEDs with wide wavelength coverage using the Spitzer GLIMPSE and MIPSGAL surveys, and the MSX and our published millimeter and sub-millimeter surveys, a carefully chosen subset of 13 HMPO candidates was modeled. The main findings are: (1) the models fit the data well with high implied envelope accretion rates ${\dot{M}_{env}} \approx 10^{-2.5} {\hbox{$M_\odot$}}/yr$, required for massive star-formation, lending credence to accretion based massive star-formation. (2) stars of masses $> 20 {\hbox{$M_\odot$}}$ may form by accretion. We also find a possible mass dependence


9.1 & $\pm$ 1.5 & $\pm$ 0.3 &\

![SEDs for the sources outlined in Table 1. (a) The three panels show representative (IRAS 18440-0148 & IRAS 19217+1651l) and the worst (IRAS 18264-1152-far) fits. The triangles denote upper limits. The solid black line shows the best-fitting model while the gray lines show all models that also fit the data reasonably well (${\chi}^2 - {\chi_{best}}^2 < \Delta N$ where $\Delta N$ = 1, 3 or 5). Since the apertures used varied between wavelengths, the fits plotted are synthetic SEDs obtained by interpolating between the different apertures. The dashed line shows the SED of the stellar photosphere in the best-fitting model. ](f1){width="7.0in"}

![(b) same as (a), for the full set of objects](fig1_b_for_astro-ph){width="6.3in"}

[^1]: available at http://www.astro.wisc.edu/protostars

[^2]: SEDs for discarded distances not presented
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a big grin on his face. Michael said, “ My young students, you are at the end of your rope. Who do you think allowed for such easy access? It was all part of my grand design. I set the bait and you took it.”

Michael Lotta paces back and forth and starts looking around the office. Michael said, “You cannot hide forever. Sooner or later I will find you.” The “four” was getting desperate. In a moment of desperation, one of the students sprays mace and yells, “Run for it!!” Michael Lotta yelled back, “Fool! This won’t help. Legions of my security officers are blocking every exit. You are toast! One of the students said, “ to the roof.”

The “four” ran to the roof. Luckily there was anIt’s been 104 months since the Demons last played finals football. In the nine years since Brock McLean led Melbourne to that not so fateful elimination final victory over the Saints on a Friday night at the MCG, the Dees have won 41 out of 185 games.

They’ve had seven different coaches in the past eight years, after having five in the 26 years prior.

From the nine-game losing streak to start 2007 to the 186-point loss to Geelong to ‘tank-gate’, Melbourne’s misery has been as diverse as it’s been consistent.

Facebook Twitter Whatsapp Reddit Email Share

And yet, when the final siren went at the MCG last Sunday afternoon, none of that meant anything.

It was all just faint noise, drowned out by the cheers of the red and blue faithful. All


material with phosphate rock towards the final product of fertilisers. Overall, the arithmetic mean of water-soluble Ca in the thoracic mass fraction was 51% (min-max: 1-100). A total of 169 personal samples were analysed for HNO(3) vapour and HF. The highest median concentration of HNO(3) (0.63 mg m(-3)) was in the compound fertiliser departments B, and all measurements but four of the HF concentrations were below the LOD of 190 μg m(-3). Exposures to NH(3), CO and NO(2) were measured using direct-reading electrochemical sensors and the time weighted overall averages were all below the LODs of the respective sensors, NH(3) 2 ppm; CO 2 ppm; and NO(2) 0.2 ppm, but some short-term peaks were detected. Even though our results indicate that the workers may experience peak exposure episodesnursing shift. Thus, burdensome dyspnea was nearly half as common as burdensome pain ([Fig 1](#pone.0152601.g001){ref-type="fig"}), and represents a substantial problem for symptom management.

Association of dyspnea with Adverse Outcomes {#sec024}
--------------------------------------------

Exertional dyspnea shortly before admission predicted adverse events in hospital in Study 1, and there was a trend toward more adverse events in patients with dyspnea at the time of admission to the unit. These findings from Study 1 suggest that dyspnea assessment may be a simple and economical way to improve risk prediction. The associations of outcome with dyspnea in Study 2 cannot, however, be interpreted as predictions because the temporal relationship between dyspnea and adverse event is not clear. In a number of cases, rapid response team activation preceded the first routine documented increase in dyspnea; because nurses


Korea eventually won the game 3–1, and Park was substituted in the 108th minute. Although Park played in the semifinal match against UAE, he was unable to find the net and South Korea lost 0–1 after UAE scored in the last minute of extra time. In the bronze medal game against Iran, Park scored his fourth goal of the tournament. With South Korea trailing 3–1, Park tapped in the ball from a cross to bring the score to 3–2. South Korea eventually won 4–3 to secure the bronze medal, with two goals from Ji Dong-won.

2011 AFC Asian Cup
Although Park had been listed on the roster for the 2011 AFC Asian Cup, he was unable to participate due to an injury and was replaced on the roster by Jiparts of a
       common scheme or plan, whether felonies or misdemeanors, all such offenses
       must be prosecuted in a single prosecution. Failure to unite all such offenses will
       result in a bar to subsequent prosecution of any offense omitted only if jeopardy
       attached to any of the offenses in the initial prosecution.

Syl. Pt. 3, State ex rel. Blaney v. Reed, 215 W.Va. 220, 599 S.E.2d 643 (2004). It is clear that the
crimes with which petitioner was charged were based upon two distinct acts or transactions, the
first being his physical altercation with the victim and the second coming some time later after an
officer encountered petitioner


Cariou is offering the songs of George and Ira Gershwin Dec. 11 at 7 PM and Dec. 13-14 at 8 PM. Doors open at 5 PM.

Cariou won the Tony Award in 1979 for his work in the title role of Sweeney Todd and was nominated for his performances in A Little Night Music and Applause. He has also been seen on Broadway in Proof, The Dinner Party, The Speed of Darkness, Teddy & Alice, Dance a Little Closer, Cold Storage, Don't Call Back, Sondheim: A Musical Tribute, Night Watch, King Henry V and The House of Atres.

There is a $35-$45 cover charge and a $25 food and beverage minimum. 54 Below is located at 254 W. 54th Street. Tickets and additional information are available at 54Below.com.the percentage of reduction is calculated. After soaking at the required temperature and time, the reaction chamber is allowed to cool to room temperature while continuing the argon flow. Air is slowly introduced to the system to passivate the reduced mass. The reduced mass is transferred to a beaker containing water, and it is treated with 20% hydrochloric acid. The resultant powder is washed with distilled water, filtered, and dried at 373 K in vacuum oven ( bar). For the second stage reduction, the powder obtained from first reduction is compacted and repeated the vapor reduction process with magnesium under the same inert atmosphere and followed by chemical treatment process. The powder thus obtained was soaked in dilute hydrofluoric acid (1% solution) for 15 minutes and washed with


that the reaction starts at the outer surface.

Figure 2: Effect of soaking time on the weight of the product at 1123 K.

Powder XRD pattern of niobium powder obtained after the first stage of magnesium vapor reduction of 5 mm pellets soaked at 1123 K for 5 hours is shown in Figure 4. It shows that, though niobium pentoxide is reduced to niobium metal, the reduction is not completed because there are significant peaks corresponding to niobium dioxide. It also shows the peaks corresponding to magnesium oxide present in the reduced mass, formed as a result of reduction of niobium pentoxide. The presence of niobium dioxide is further confirmed by the oxygen analysis. Oxygen content of the reduced mass leached with HCl is as high as 8% (Table 2).be out 8-10 weeks. The injury,
which came in the 8th minute of his 100th Bundesliga, was a huge blow as he had been playing very well to draw the attention of U.S. national team Jurgen Klinsmann,
in whose doghouse he's been for much of the last year.

It was a rough day for Nuremberg, which lost young striker David Ginczek for six weeks with a knee injury (cruciate
ligament). Both players were scheduled to have surgery Monday in Augsburg.

-- Also unable to play was Oguchi Onyewu, who had been making a late bid
since his move to Sheffield Wednesday. Once again, Sacha Kljestan did not get off the bench at Anderlecht, where he has made one league appearance in the last
two months.

German-American Andrew Wooten scored on his first touch with his new


Q:

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Exactly every 2 minutes my server restarts the GET request before the initially started query is finished. This leaves my server with another started query every 2 minutes until the first query finishes and sends the callback.
This is the line of code that I am using for the scan.
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       the IL-1 receptor, which can lead to inflammation when defective, and in phase II studies it demonstrated an ability to reduce inflammation.

Xoma holds rights to the drug in the US and Japan for non-cardiovascular indications, including uveitis and Behçet's disease, while Servier holds all other rights.


The data contains potentially identifiable patient information and cannot be shared publicly due to ethical and legal restrictions. However, the data of the SONABRE registry is organized according to the FAIR principles and researchers who meet the criteria for access to confidential data can submit their requests for data (and the R source code of this study) to the registry's PI prof. V.C.G. Tjan-Heijnen (<vcg.tjan.heijnen@mumc.nl>).

Introduction {#sec005}
============

Advanced breast cancer (ABC) is a common type of cancer among women and a leading cause of cancer death worldwide \[[@pone.0230909.ref001],[@pone.0230909.ref002]\]. Even though some patients live with ABC for many years, the disease is considered incurable, and the main objective of care is to prolong survival and sustain quality of life. Due to its high prevalence and high individual treatment costs, the economicprices and expressed in €2017. If necessary, costs were inflated using the consumer price index \[[@pone.0230909.ref011]\]. When guideline prices were not available, prices were retrieved from other sources, including internal cost prices from the Maastricht University Medical Centre +, which are confidential and cannot be reported. All other unit prices are provided in [S1 Table](#pone.0230909.s001){ref-type="supplementary-material"} in the Electronic Supplementary Material. In addition to monthly costs, we also computed the total end-of-life costs per ABC patient, i.e. the costs incurred over the last twelve months before death, or, if survival time was shorter, between ABC diagnosis and death.

Statistical analysis {#sec009}
--------------------

Statistical analyses were conducted in four sequential steps. First, we descriptively assessed the average trend in costs for the entire cohort of deceased ABC patients over the last twelve months


claims, which are commonly used to investigate health care costs \[[@pone.0230909.ref008],[@pone.0230909.ref018]\], we were able to further investigate potential reasons for the uncovered variability in patients' cost trajectories. It should be noted that we did not aim to develop a model to predict a patient's cost trajectory in advance, say at the date of diagnosis. The variables in the model, which in part could only be assessed after death, were not suitable for this purpose. Rather, we aimed to study to what extent patient- and treatment-related factors together could explain differences between patients' cost trajectory groups. Some of the associations found appear immediately intuitive: death in hospital, for example, independently increased the likelihood of patients to belong to a group with peak costs at the end of life (groupsas a parameter to monitor disease severity over time.

Our analysis is exploratory in nature, and findings should be interpreted within this context. An important point to stress is that our results cannot be generalized to a wider population of ABC patients. We included patients diagnosed since 2010 who died before June 2017, which makes our sample somewhat biased towards individuals with a shorter survival time when compared with the general ABC population. Furthermore, seven hospitals were included, which might also limit external validity. However, among the seven were academic, teaching and non-teaching hospitals, which should be considered a strength of this study. Also, our study had a strict hospital perspective, which implied that resources consumed in other areas of health care, such as general practitioners or hospices, were


clinical characteristics, economic evaluations of treatments in ABC patients should aim to account for the heterogeneity of costs between and within patients over time.

Conclusions {#sec021}
===========

Average costs of ABC patients in the Netherlands increased over the last twelve months before death, mainly driven by hospital admissions. From this average trend, however, no inferences can be made with respect to individual patients or subgroups of patients. Our findings indicate that there are several latent groups of patients with distinct cost trajectories. None of them reflected the overall trend.

Supporting information {#sec022}
======================

###### Unit costs.

(DOCX)

######

Click here for additional data file.

###### Final zero-inflated Poisson model---Beta coefficient point estimates.

(DOCX)

######

Click here for additional data file.

###### Final zero-inflated Poisson model---Beta coefficient point estimates for the subgroup of patients with at least 12 months survival timeof the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data---e.g. participant privacy or use of data from a third party---those must be specified.

Reviewer \#1: Yes

Reviewer \#2: No

Reviewer \#3: No

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4\. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer \#1: Yes

Reviewer \#2: Yes

Reviewer \#3: Yes

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5\. Review Comments to the Author

Please use the space provided to explain your answers to the


later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact <onepress@plos.org>.

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10.1371/journal.pone.0230909.r004

Acceptance letter

Buyukhatipoglu

Hakan

Academic Editor

© 2020 Hakan Buyukhatipoglu

2020

Hakan Buyukhatipoglu

This is an open access article distributed under the terms of the

Creative Commons Attribution License

, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

13 Mar 2020

PONE-D-19-22901R1

Variability of cost trajectories over the last year of life in patients with advanced breast cancer in the Netherlands

Dear Dr. Schneider:

I am pleased to inform you that your manuscript has been deemed suitable for publication in PLOS ONE. Congratulations! Your manuscript is now with our production department.

If yourin lung cancer ([@b17-etm-0-0-4875]). Liu *et al* ([@b18-etm-0-0-4875]) also found that knockdown of TFAP4 inhibited gastric cancer cell proliferation, induced apoptosis and sensitized cancer cells to anti-cancer drugs, indicating that TFAP4 has a potential drug target value in the treatment of gastric cancer.

TFAP4 was also identified as a prognostic factor in several cancer types, including gastric cancer ([@b7-etm-0-0-4875]), hepatocellular carcinoma ([@b8-etm-0-0-4875]) and non-small cell lung cancer ([@b9-etm-0-0-4875]). However, the prognostic value of TFAP4 in CRC has remained elusive. To investigate this, the present study assessed TFAP4 protein levels in a TMA containing 193 CRC and 8 normal colon tissues. IHC analysis revealed that TFAP4 was located on the plasma membrane and in the cytoplasm of CRC cells, and TFAP4 was upregulated in CRC compared with normal tissues. In


the view that in order to understand people’s privacy perceptions and behaviors, we need to adopt a situational perspective. To this end, the book is divided into three… Read More »Book published: Situational Privacy and Self-Disclosure

Welcome!

I am a researcher in the field of communication science working at the Department of Communication at the Johannes Gutenberg University Mainz (Germany). Previously, I was a research assistant at the University of Hohenheim (Germany) and a visiting scholar at the Cornell University (Ithaca, USA). On this website, you can find information about my research interests, publications, teachings, and some personal background.

From time to time, I take pictures of things and people. You can find them here.

The cookie settings on this website are set to "allow cookies" to give you the best browsingof the board of the Nigeria Basketball Federation.

Off the court

Oyedeji is a philanthropist and is committed to empowering youths using the tool of basketball as the medium for change. He is founder and CEO of his initiative Olumide Oyedeji Youth Foundation (OOYF) was established in 2000 as a Nonprofit /Charity Corporation in the US, United Kingdom and Nigeria. The focus of the organization is to help underprivileged, troubled and at-risk teens make better choices and create a brighter future for all. OOYF has produced over 300 scholarships to youths since its inception in 2000. Over 40,000 youths from all over the world have participated in the programs since the foundation was established. It has operated in more than 30 cities in Nigeria, and over 20 different cities


had never thought in my nightmares that I have to live by begging from people. The night coach fell from the bridge and unbelievably I was alive. I was alive by becoming a disable. My youngest son often asked me where had I left my other hand. And my daughter Sumaiya feed me every day by saying she knows how difficult it is to do all work with one hand.

After two years my daughter is wearing a new dress, that’s why today I brought her with me to play for some time. Maybe I will not be able to earn anything today, but I wanted to roam around with my little girl. I secretly borrowed this mobile phone from my neighbour without informing my wife. My daughter hasno picture and I want to make this day memorable for her. When one day I will have a phone I will take a lot of pictures of my children. I want to keep good memories. It’s very difficult to send my children to school, but I am educating them all. Sometimes they cannot attend the exam because giving exam fees is not always possible by me. On those days they feel very sad then I tell them, sometimes we can miss exams because the biggest exam is life which we are giving every day.

Now I will go for begging. I will place my daughter in a signal where she will wait for me. I will look at her from distant while begging. I feel shame while she


on social issues,” she told NBC News. “We wanted Apple to take a stand on America's gun violence epidemic by publicly supporting federal regulations to keep guns out of the wrong hands."

NYAGV’s Twitter campaign encouraged users to tweet Tim Cook and have him remove the gun emoji from iPhones, to “show America wants stricter access to real guns.”

Many Americans believe that the “emoji gun” issue is taking aim at the First Amendment.

“What’s the point in having the emojis if it’s going to come down to a judge saying whether or not we should be able to use them?!” asked one Facebook user on a thread discussing the Virginia middle school student’s arrest. “Whatever happened to free speech?”

Read More: Meet the 67 Emoji Candidates for 2016: Shrug, Selfie, 'Calltheir own prevention plans (which are then funded), could go a long way to mitigating local hostility, where that hostility is based on feelings of helplessness and despair.

Above all, there is a need to trust in local common sense, once the nature of the epidemic and the infection risks it poses have been made clear. As Albert Camus remarked in his novel The Plague: “What we learn in the time of pestilence is that there is more to admire in people than there is to despise.”

Susannah Mayhew is a professor of health policy and systems at the London School of Hygiene & Tropical Medicine.

Samuel Boland is a social science researcher at the London School of Hygiene & Tropical Medicine.

Dan Cohen is a consulting biological scientist from Davis, California.

Gillian


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        }];
       tempView.frame=CGRectMake(0, 0, 320, 480);
        [self.view addSubview:tempView];

Update :
First take object of UIView in your .h file like
UIView *tempView;
BOOL isOpen;

in viewWillDidLoad: method just define this
isOpen = NO;

and after use this code
-(IBAction)btnSetting_Clicked:(id)sender
{
    if (isOpen) {
        isOpen = NO;
         [tempView removeFromSuperview];
    }
    else {
        isOpen = YES;
      Introduction {#Sec1}
============

Our understanding of the role of the immune response in suppressing the emergence of malignancies and limiting metastases continues to evolve. It has been generally accepted that the local microenvironment influences the regulatory processes in tumour tissue via chemokine- and cytokine-related signalling pathways, highlighting context-specific biological functions of the tumour tissue framework. One of the prompt responders to tissue insult is a collection of Innate Lymphoid Cells (ILCs), which can modify immune responses to the needs of local tissue microenvironment. ILCs are currently divided into three main groups, which are defined by cell-surface markers and by the cytokines they produce^[@CR1]^. Two ILC subsets have been implicated in tumour immunity, including Group 1 ILCs (ILC1 or natural killer (NK) cells)^[@CR2]^ and Group 3 ILCs (ILC3)^[@CR3]--[@CR5]^. However, the role


(CTL) immune recognition^[@CR21]^. Moreover, down-modulation of IL-33, together with down-modulation of antigen processing machinery and MHC-I-related genes during the primary to metastatic transition in tumours, represents a newly defined form of tumour immune-escape. Based on these clues, we hypothesized that since ILC2s are developmentally and functionally dependent on IL-33, ILC2s may have an undescribed role in promoting and mediating immune responses against tumours. As a test of this hypothesis, we examine whether the lack of ILC2s supports tumour progression. These data help to revise our knowledge of immunity to emerging and metastatic malignancies.

Results {#Sec2}
=======

Tumour study models {#Sec3}
-------------------

Currently, the tumour mutational landscape and eventual treatment decision commonly rely on the molecular profiling of the primary tumour at early stages, without information on possible genetic and epigenetic alteration during diseasevivo* {#Sec6}
-----------------------------------------------------------------------

To directly examine the role of ILC2s and IL-33 in cancer development, we conducted a comparison of the progression of the primary (TC1) or metastatic (A9) tumours, with and without IL-33-gene complementation, in mice transplanted with bone marrow (BM) from either wild type (WT) mice or mice lacking ILC2s (RORα^−/−^). RORα^−/−^ mice have severe neurological defects and do not survive long past weaning, however, RORα^−/−^ BM-transplanted mice are ILC2-deficient while retaining functional immune cells including Th2 cells and RORγt^+^ ILCs^[@CR27]^. Therefore, BM chimeras were generated by reconstitution of lethally irradiated B6.Pep3b (CD45.1) mice with whole BM cells from either 4-week-old WT or RORα^−/−^ (both CD45.2) mice. BM transplant recipients were allowed to recover for 6 weeks, and the quality of the BM transplantation was analysed by FACS,


transplanted with WT BM, we unexpectedly detected the formation of metastases from the primary TC1 tumours in ILC2-deficient mice transplanted with RORα^−/−^ BM. We detected a considerable frequency of CTCs in adrenal glands, lungs and brains (Fig. [5a](#Fig5){ref-type="fig"}) of mice transplanted with RORα^−/−^ BM that bore primary TC1 tumours, even though we have shown in Table [1](#Tab1){ref-type="table"}, that this cell line is not predisposed to move to distal sites in WT animals. Overall, these data indicate that ILC2s are important for controlling metastatic spread of both primary and metastatic cancer cells. Furthermore, the presence of IL-33 in the microenvironment augments the anti-cancer function of ILC2s.Figure 5Functional ILC2 cells are important in controlling the metastatic spread of the tumours. (**a**) Spread of EGFP-positive circulating tumour cells (CTC) to distal organs wasand B lymphocytes received from the RORα^−/−^ and WT mice were equivalent in their functional ability to limit TC1 tumour growth (Fig. [6b](#Fig6){ref-type="fig"}). Collectively, these data demonstrate that ILC2 cells contribute to the ability of lymphocytes to mediate an immune response against tumours and, reciprocally, lymphocytes require ILC2s to carry out this function.Figure 6RORα^−/−^ mice produce functional lymphocytes. **(a)** Immune cell count in the peripheral blood of (WT → RAG^−/−^) and (RORα^−/−^ → RAG^−/−^) animals, as well as in the WT and RAG^−/−^ control animals. **(b**) The T and B cells isolated from the RORα^−/−^ and WT mice were equivalent in their functional ability to suppress the tumour growth to the level of the WT control group, however, the tumour growth was significantly higher in RAG^−/−^ control group when compared to the (RORα^−/−^ → RAG^−/−^)


the CD8a^+^ T cells (Fig. [7b](#Fig7){ref-type="fig"}) and the increased cellular killing seen by microscopy (Fig. [7c](#Fig7){ref-type="fig"}) further indicates that the CTL effector mechanisms have been heightened in the presence of ILC2s, providing a mechanism for ILC2 action in anti-cancer immunity.Figure 7Impact of ILC2s on specific CTL effector mechanisms. Co-culture of metastatic murine prostate TAP-1-low carcinoma cells (LMD) and CD8 T cells with ILC2s (right panel) or without ILC2 cells (left panel): (**a**) TAP-1 expression level in LMD cells after activation with ILC2 cells (right) and without ILC2 cells (left); (**b**) Granzyme b expression by CTL cells in the absence of ILC2s (left) or in the presence of ILC2s (right); (**c**) Light microscope images of cell co-cultures after the incubation with CTLs show the extent of CTL-mediated killing, either in thethe transcriptional profile of metastatic tumour cells before and after genetic modification with IL-33 gene. We found that components of the antigen processing pathway (H2-K1, β2 m) were elevated in A9 metastatic tumours expressing IL-33, whereas the expression of immunosuppressive factors (IL-10, Ptgs2) were diminished, thereby altering the tumour microenvironment toward immune responsiveness. Furthermore, a variety of immune chemoattractants were found to be increased in metastatic A9+IL-33 cells when compared to metastatic A9 alone (Fig. [8](#Fig8){ref-type="fig"}): CXCL2 (attracting neutrophils); CCL5 (attracting macrophages); and CSCL10 (attracting NK and CD8+T cells). These chemoattractants are secreted by the IL-33 expressing tumour, and have been previously shown to create a permissive environment for infiltration of the immune cells^[@CR36]--[@CR39]^. The resulting changes in gene expression induced by IL-33 enables host to overcome the immunosuppressive state to constrain


monoclonal antibody (553570, BD Pharmingen).

### Flow Cytometry {#Sec26}

BD FACS Aria II was used for cell sorting and phenotypic analysis. The program FlowJo v.8.7 was used for data analysis.

Mice C57BL/6 (Cat\# 000664), B6.Pep3b (B6.SJL-Ptprca Pepcb/BoyJ), RAG1^−/−^ (Cat \#002216), OT-1 (C57BL/6- Tg(TcraTcrb)1100Mjb/J, Cat\#003831)^[@CR55]^ mice were purchased from the Jackson Laboratory. RORα^−/−^ (C57BL/6J-Rorasg-3J/J) mice are not available commercially, but were made by Fumio Takei and maintained at the British Columbia Cancer Research Centre (BCCRC). All animals were maintained in specific pathogen-free facilities: either the BCCRC animal facility or the Centre for Disease Modeling at the University of British Columbia (UBC). Mice were used between 4--8 weeks of age. All mouse experiments were approved by the Animal Care Committee at UBC. Animals were maintained and euthanized under humane conditions in accordance withacetone:methanol. Following washing in Tris-buffered saline (TBS, pH 7.4), slides were incubated with protein block and subsequently incubated with specific antibodies overnight. Appropriate horseradish peroxidase (HRP) conjugated secondary antibodies were used for detection of the primaries and developed with DAB chromogen. Slides were counter stained with haematoxylin and eosin (H&E) and dehydrated in ethanol and xylene. Giemsa staining was used to detect eosinophils. Slides were then cover-slipped and imaged with an Aperio ScanScope at 20x magnification. Tumours were embedded in Tissue-Tek O.C.T. media on dry ice and immediately stored at −80 °C until sectioning. 5 µm thick sections were collected on a Leica cryostat and stored at −80 °C until staining. Slides were removed from −80 °C, fixed in cold acetone. Following washing in TBS, slides were incubated with protein


(BCCRC) animal facility or the Centre for Disease Modeling at the University of British Columbia (UBC). All mouse experiments were approved by the Animal Care Committee and veterinarians at UBC, who oversee both animal facilities. Animals were maintained and euthanized under humane conditions in accordance with the guidelines of the Canadian Council on Animal Care (CCAC).

Electronic supplementary material
=================================

 {#Sec37}

Supplemental Figure 1

**Electronic supplementary material**

**Supplementary information** accompanies this paper at 10.1038/s41598-018-20608-6.

**Publisher\'s note:** Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

We thank Andrew Johnson for technical assistance with flow cytometry. This work was funded by three CIHR grants to WAJ: MOP-86739; MOP-97900; NHG 107769. FT was supported by CIHR grant MOP-119324. FF was the recipient of a fellowship from the Austrian Academy of Sciences.

I.S. -- experimental design,having a conversation with a bird statue a few blocks down (yes conversation, not monologue).

He even drew me a picture.

Towards the end of our time together he began to berate and yell at another customer as he was leaving McDonald’s because the guy at my table was convinced that he was the governor of Colorado and couldn’t figure out why he didn’t want to have a conversation with him.

Since the moment we first began to talk I had a nudge to engage his guy and talk to him. I kept hearing in my mind, “Treat this guy like Jesus.” Which of course meant that I would need to act like Jesus.

How do you extend grace, fellowship and company to someone that drunk, disoriented and out of it all


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our UK website where all the prices are listedgovernment faces accusations that cutbacks to tax credits are pushing low-income families into poverty while the successor, universal credit, is technically flawed, leading to long delays and miscalculated payments.

The thinktank said the drop in incomes for the poorest was modest at 0.3% but the impact was greater after a weak recovery in wages over the previous decade. A typical middle-income household saw a rise of only 0.9%, although this was the weakest since 2012, and a marked slowdown from the 1.6% rise in 2016-17, and the 2.5% average in the 10 years before the financial crisis.

The top 30% of households also widened the gap with the poorest 30% but incomes at the top only rose by 0.4%.

“With the middle pulling away from the bottom, child poverty is projected


In accordance with industry accepted best practices we ask that users limit their copy / paste of copyrighted material to the relevant portions of the article you wish to discuss and no more than 50% of the source material, provide a link back to the original article and provide your original comments / criticism in your post with the article.

THESE VIDEOS HAVE BEEN TAKEN DOWN.You can find Danny Wilten's material on hisUTUBE channel.

ASTONISHING facts on the video include somethingsome of us have NOT HEARD ABOUT YET: The 12/03/12 THE 4 PLANET "EVENT" to happen in GIZA, Egypt!This rare event (Wilten and Graham Hancock explainin Part2 video JUST HOW RARE--3-planet alignmentof Mercury, Venus, and Saturn...(with MARS at a bizaar triangulation near the alignment) on December 3,2012! Interesting?....What about theand Part 2 (each about 8 min.)The VIDEO discusses the up-comingdate of: 12-03-12. It is the RARE planetary alignment but also with some DISTURBING "coincidences." PLEASE.... watch the video first before continuing!! [link to www.youtube.com]

[Summary of the Part 1 & Part 2 Wilten videos:]So...Part 1 Wilten explains the significance ofthe Sacred & HOLY "Belt Stars" alignment of Constellation Orion--Divine in ANCIENT Egypt)--lined up overthe 3 Great Pyramids of Giza in Ancient Egyptand how this "EVENT" was seen as an OMEN/Celebration.But...GUESS WHAT!??? THE ORION ALIGNMENT HAPPENEDIN 10,900 b.c.Wilten tells us that "10,900 B.C." is a huge'DIP' in the "Time Wave Zero" program and thatTHERE MAY HAVE BEEN "SOME SIGNIFICANT EVENT"(NOT NECESSARILY DOOM--POSSIBLE CONSCIOUSNESS SHIFT?)IN THAT ERA! (Graham Hancock also confirms this!)For us, in 2012...our 3-planet alignment ofMercury, Venus and


};

    /** a comparator to use for descending alphabetic sorting */
    public static final Comparator<Object> alphabeticDescendingComparator =
      new Comparator<Object>() {
          @Override
          public int compare(Object object1, Object object2) {
              return -alphabeticAscendingComparator.compare(object1, object2);
          }
      };

    /**
     * for convenience, an enumeration of pre-defined comparators for use
     * with setSorting
     */
    public enum*
     * @param comparator the sorting comparator, or null
     */
    public void setComparator(Comparator<Object> comparator) {
        if (this.comparator != comparator) {
            this.comparator = comparator;
            fireRootChangedEvent();
        }
    }

    /**
     * a convenience method for setComparator, using a predefined
     * set of options
     *
     * @param sorting the sorting to apply
     */
    public void


very sick with aids, which is why his skin tone changes from time to time. However, it is always important to note which Obama you are looking at. Just like Hillary and the rest of them. After the life he has had, the torture, rape, mind control and the Satanic brainwashing done by the Jesuit elite who control him, what more could we expect, but a ruthless, bloodthirsty tyrant?

HR 1540 and all of his other executive orders (EOs) have set up the foreign dictator perfectly to complete his task with absolute compliance and silence from the citizens. He has already murdered over 250 million citizens that we know of, in the last couple of years. Citizens of the USA have been rounded up and taken away in theplan of the elite. They play both sides. And this war has been planned and been in the making for centuries.

And so long as the people sleep. So long as the people who call themselves good people stay silent and do nothing. Evil will run rampant and we will all die by disease and violence.

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Extension of http://saianarchy.com Here we will post updates and further details and answer questions we receive from people, about the NWO and what is happening today! ________________________ The elite use terms to confuse us. They us many different terms to mean one thing. We have discussed much of this in the document below and as it is expected you know what the contents of that are before continuing on


who cannot
live without planning ever new and dreadful outbursts of rebellion! I
shall be among them!...All societies tremble when the scornful
aristocracy of tramps, inaccessibles, unique ones, rulers over the ideal
and conquerors of the nothing resolutely advances. So, come on,
iconoclasts, forward!

The sublime conquest of nothing! The only ground that truly exists, the only firmament where our stars can be hung, is nothingness itself. And nothingness is itself not a thing. Flowing emptiness -- endless, timeless, vacuumous and ecstatic. Beyond Church and State, Time and Space, Ear and Eye, Saturn and Jupiter. Hermetic anarchism should be first to be tossed on the intellectual bonfire of the vanities.

But of what practical use is this? How is this in any sense realistic? How does this help the suffering masses of Syria -- toan ideal future order. In contrast, Proudhon left Hegelright side up, maintaining the Hegelian image of history as a processof ideas unfolding through contradictions.

But Proudhon insisted that the agony of contradiction would not leadto despair or resignation as long as man did not look on the situationwith complacency or cynicism. The real answer for society was notthe mythic conclusion of some future, final synthesis; but the realisticpossibility that at every stage the contradictions which are part andparcel of life itself could be held in equilibrium. Proudhon spoke of adynamic ever-changing equilibrium: an "equilibration" between forcesthat would never either vanish or lose their venality. The balancing ofsuch rival forces, though always tense and precarious, was the highestgood that man can hope for on earth. -- Fire in the Minds


they are creating nothing but
confusion. Or they do know, and in that case they are betraying the
cause of the proletariat. In either case they serve only reaction. -- quoted in The State and Revolution

The authoritarian nature of revolution is hard to deny. The dire necessity of using force in order to remove force is one way that violent revolution is justified by classical anarchists. Another possibility, though, is to change our understanding of revolution. The revolution, or perhaps a more neutral term like "the ruckus" is preferable, could be defined as any action that moves towards individual autonomy and freedom and away from authoritarian control.

The ruckus, in this sense, is perpetual and all-pervasive. It continually creeps closer to anarchy but it never entirely reaches it. And yet itimagination set absolutely free. Total control may be only a hairsbreadth away from total liberation, just as the State's most effective strategy against a guerrilla insurgency is to go guerrilla itself.

It is not the internet that is liberating humanity, it is the collective imagination that is surfacing and manifesting as the architecture of the world soul.

The net is not the world; it is the imagination of the world. -- The H.D. Book (1961)

Already the parasitic middlemen are falling away, becoming irrelevant. In the music industry, in the film industry, the transformation is occurring in any place where information is abundant and can be given away without loss -- in education, in media, in medicine, even in design and manufacturing. And the trajectory here is extremely clear. The final


a beautiful purpose. They had no other King but God Himself and their purpose was to be a light to the Gentiles. Then this religion was corrupted by "Judaism", with its many rules and regulations; which actually decided it should be a sin to even sit with a Gentile, thus making the Word to no effect. Just one example of how (in my own small world) adding the -ism completes the prism. Arminianism and Calvanism have likewise destroyed the Word of God. The world will accept anything that allows our egos to be puffed up, and for this reason I feel like the ultimate religious and political system of the world is and always will be (until the End) Contradiction-ism. However I don't blame the world for this.we first used our “es-health” Docker image to monitor our Elasticsearch clusters. This served us well to a certain degree, but we still felt like it was not enough for real-time, complex analysis.

We were already using Graphite to retrieve real-time metrics from all of our microservices (using this Docker image / Java Agent), so we decided to try to analyze our Elasticsearch clusters with Graphite as well.

The successful result of this engineering effort was a lightweight Docker image that serves the purpose of monitoring Elasticsearch perfectly.

How does it work? It’s pretty simple. Once at every set interval, a request is made to

the /_node/stats API on an Elasticsearch cluster of your choice. We recurse on those values and use the “pickle” protocol to send any numeric metric found to


being perhaps being the most sought after TR of all).

The TR7 had a dreadful reputation, (I owned a late 70's Speke built example when I lived in the UK in the early 80's, it never broke down but it did dissolve very rapidly) but despite this, it outsold every previous TR model produced and eventually matured from the "ugly duckling" hard top piece of cheese (which in today's market appears remarkably fresh) to the sleek drop head pictured above.

A Sharper 7'

I suppose it's important to point out at this stage that our 6' is a completely standard "concourse queen" and remains totally unmolested (Lynne having forbidden medling as it is her car), whilst the 7' has been progressively "improved" over several years of ownership to meet my ownThe ATPase, RNA unwinding, and RNA binding activities of recombinant p68 RNA helicase.
p68 RNA helicase, a nuclear RNA helicase, was identified 2 decades ago. The protein plays very important roles in cell development and organ maturation. However, the biological functions and enzymology of p68 RNA helicase are not well characterized. We report the expression and purification of recombinant p68 RNA helicase in a bacterial system. The recombinant p68 is an ATP-dependent RNA helicase. ATPase assays demonstrated that double-stranded RNA (dsRNA) is much more effective than single-stranded RNA in stimulating ATP hydrolysis by the recombinant protein. Consistently, RNA-binding assays showed that p68 RNA helicase binds single-stranded RNA weakly in an ATP-dependent manner. On the other hand, the recombinant protein has very high affinity for dsRNA. Binding of the protein


may be used to make the following work:
<%
    HashMap map = (HashMap)session.getAttribute("map");
    map.put("key","value");
%>

i.e. change the state of an object that has already been put in the session and you can be sure that this object still be replicated to the other nodes in the cluster.
According to the Tomcat 6 documentation you only have two "Manager" options - DeltaManager & BackupManager ... neither of these seem to allow this option or anything like it. In my testing the default setup:
  <Cluster className="org.apache.catalina.ha.tcp.SimpleTcpCluster"/>

where you get the DeltaManager by default, it's definitely behaving as useDirtyFlag="true" (as I'd expect).
So my question is - is there an equivalent in Tomcat 6?
Looking at the source I can see a manager implementation "org.apache.catalina.ha.session.SimpleTcpReplicationManager" which does have                 log.debug(getInfo() + ": [session=" + session.getId() + ", context=" + context + ", request=" + task + "] maked DIRTY");
                }
            } else {
                // for everything else - cycle all attributes
                List cycledNames = new LinkedList();

                // in a


    }
        } else {
            String id = request.getRequestedSessionId();
            log.warn(getInfo()  + ": [session=" + id + ", context=" + context + ", request=" + task + "] Session not available, unable to send session over cluster.");
        }
    }

    /*
     * ClusterValve methods - implemented to ensure this valve is not ignored by Cluster
     */

    public CatalinaCluster getCluster() {
        return cluster;
 testified it was reimbursement for a centerpiece defendant personally paid for, although she had made a prior inconsistent statement.

4
Mrs. Vancil testified that the $212 was for gratuities for the entire staff, but defendant testified the tip was all for her.  Whatever the truth as to entitlement to the $80, there was ample proof to support the finding that the $212 was a tip for all the employees who worked at the party, and not for defendant alone.  Defendant cannot succeed in attacking that finding on appeal.

5
Defendant does argue that as a matter of law tip money intended for distribution to individual employees was not "any ... money, or thing of value of the United States or of any department or agency thereof" as prescribed in 18


the style, but the one I created just felt better.

I like the classic romans type, this type has good things, but some need adjustment
As allways i leave you my suggestion, take it or leave it, but i hope i can help:

+ You have problems with the widness of the letters. What romans did was construct the letters from squares, triangles, circumsferences and half a square.
+ The "J" looks original but it might be confused with the "I", try making it more different
+ The "V" is bold
+ The top "F" arm is thin if you compare it to the "E", the middle arm should be at the same heigt in E and F.
+ The "I" might be bold
+ The lower arm of the "K" might be bold, compare ita C.

Music is a intelligent theme with unique features for the music industry. It’s easy to use and easy to customize.
I like the variety of useful features included, and the clean design of the icons and UI elements.

An excellent joystick element for an iPhone game that simply oozes with detail.
The crisp lines and touchable textures help to make this joystick work visually, whether it works practically on the iPhone is another matter entirely.

A simple, but effective, interface element that just works. It could be even more effective if there was a little more texture on the control itself.
I like the faded lights around the outside of the knob.

A beautiful example of an interface element, an analog control to be precise. I particularly like the attention to detail and


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SGM Herbert A. Friedman (Ret.)

Note: Portions of this article were previously published in the Whitman Numismatic Journal, July 1967 and September 1967, and the International Banknote Society Journal, Volume 24, Number 1, 1985 and Volume 30, Number 1, 1999. Some illustrations from this article were used by The Centre Pompidou (Paris) for the autumn 2015 issue of "Les Cahiers du Muse national dart modern." The origin of the term "Cold War" is usually attributed to Bernard Baruch, advisor to many American presidents during the turbulent post-war years. There is no single definition of this term, but we understand it to be a state of continual diplomatic adversity where the great philosophies of the East and West contend on every level except for the


is Reggie Chartrand, their leader. The Royal Canadian Mounted Police captured and destroyed the main hoard of notes after the October 1970 crisis that saw the kidnapping and death of Quebec labor minister Pierre LaPorte and the kidnapping of British trade commissioner James Cross. The FLQ was formed about 1963 as a cellular terrorist organization with Cuban trainers. On the night of 15 October 1970 The Canadian government declared martial law in Montreal. The military searches turned up weapons, explosives and propaganda leaflets printed in China and Cuba. A second banknote parody is a Canadian "FLQ" terrorist note, black on green, inscribed "Une piastre" and "Bastille 1789/Quebec 19??." The leaflet was issued by the Front for the Liberation of Quebec. The front and back are similar, with aBay of Pigs, Peter Wyden, Simon and Schuster, New York, 1979. Wyden says: When two million worth of pesos came ashore in four jute sacks that had gotten wet, the sacks were leaking blue, red, and green liquid, but the underground workers were only mildly annoyed. They knew that the CIA was sending them counterfeit money; that the printing and the paper were excellent but the ink was so unreliable you could usually wipe it off with saliva. The counterfeit money, tens and twenties, was used by middlemen who bought expensive items such as cars from people they hoped never to see again. The currency supplied to the infiltrators for their own use was authentic; at least the ink did not run. The forgeries are rather easy to


for you: a History of U.S. Army Combat Psychological Operations: The use of a Cuban rather than a Grenadian note showed that planners were understandably more concerned with resistance from the Cuban construction battalions than any from the rag-tag Grenadian local defense forces. Before we leave this interesting propaganda leaflet that parodies a Cuban 5 peso banknote we should point out that the U.S. military apparently liked this vignette. In the years afterwards the same banknote leaflet was used numerous times in war games and training exercises where U.S. Army Special Forces had to work with and pay mock rebel forces. Here, in a war game between the nations of Costa and Ventura this banknote offers safe conduct and humane treatment to any soldier of Costa who turnswith Radio Free Europe, designed a leaflet and radio attack to take advantage of the situation. The leaflets were ordered by Free Europe Press, a division of the Free Europe Committee and prepared by Reynolds Offset, a New York City print shop, in sheets of 40 (8 across and 5 down). Ken Graeber was the printer. He said: The two men who brought it into the plant made any number of cryptic remarks about its secrecy. We would be reading about it soon they said, and there were remarks about "balloons." I do not recall how many we printed but it was not one of our larger jobs... perhaps less than three days run on the press. This project was explained in a small booklet entitled A New