The build-up to the returning French GP has been plagued by traffic problems around the Paul Ricard circuit, which is only immediately accessible by one road.

That has triggered huge tailbacks into the surrounding areas, with F1 personnel and spectators queuing for hours to get to the track.

For Friday’s practice day the local authority, which is responsible for traffic management, made the main road into the circuit accessible in only one direction, via a single lane, for spectators.

It was also operating car parks – which have a total combined capacity of 25,000 places – on a one-by-one basis, filling them to the maximum before opening the next one.

A statement from the Var prefect, the local authority, said that in conjunction with the organiser they had decided to open allstance on Sunday.

A spokesperson said: “The Australian government considers engagement with Sri Lanka to be the most effective way to encourage progress on human rights issues. Genuine advances in accountability and reconciliation will only be possible with the co-operation of the Sri Lankan government.”

The Australian government said it would work closely with the Sri Lankan government, opposition parties and other groups to promote reconciliation in the country.

But it remained silent yesterday on its plans to transfer the asylum seekers into the custody of Sri Lankan authorities.

Fairfax and other media organisations, as well as human rights organisations such as Human Rights Watch and the Human Rights Law Centre, have documented cases of asylum seekers who have been tortured upon return to Sri Lanka.

The Asian Human Rights Commission has detailed


#
# DO NOT ALTER OR REMOVE COPYRIGHT NOTICES OR THIS HEADER.
#
# Copyright (c) 2010-2011 Oracle and/or its affiliates. All rights reserved.
#
# The contents of this file are subject to the terms of either the GNU
# General Public License Version 2 only ("GPL") or the Common Development
# and Distribution License("CDDL") (collectively, the "License").  You
# may not use this file except in compliance with the License.  You can
# obtain a copy of the License at
# https://glassfish.dev.java.net/public/CDDL+GPL_1_1.html
# or packager/legal/LICENSE.txt.  See the License for the specific
# language governing permissions and limitations under the License.
#
# When distributing the software, include this License Header Notice in each
# file and include the License file at packager/legal/LICENSE.txt.
#
# GPL Classpath Exception:
# Oracle designates this particular file as subject to the "Classpath"
# exception as providedits licensees as provided above.  However, if you add GPL Version 2 code
# and therefore, elected the GPL Version 2 license, then the option applies
# only if the new code is made subject to such option by the copyright
# holder.
#

-exportcontents: org.glassfish.ejb.api; \
                 org.glassfish.ejb.spi; version=${project.osgi.version}


<?xml version="1.0" encoding="UTF-8"?>
<!--
/*
 * DO NOT ALTER OR REMOVE COPYRIGHT NOTICES OR THIS HEADER.
 *
 * Copyright (c) 2013 Oracle and/or its affiliates. All rights reserved.
 *
 * The contents of this file are subject to the terms of either the GNU
 * General Public License Version 2 only ("GPL") or the Common Development
 * and Distribution License("CDDL") (collectively, the "License").  You
 * may not use this file except in compliance with the License.  You can
 * obtain a copy of the License at
 * https://glassfish.dev.java.net/public/CDDL+GPL_1_1.html
 * or packager/legal/LICENSE.txt.  See the License for the specific
 * language governing permissions and limitations under the License.
 *
 * When distributing the software, include this License Header Notice in each
 * file and include the License fileWoman before leaving for the same reasons.

AQUAMAN: July 2018

And right off the heals of The Flash news, Birth.Movies.Death has heard that there are some problems with Zack Snyder behind the scenes with Warner Bros. and has also spilled into the Aquaman camp as director James Wan is currently nervous about his project based off of the response from Batman v Superman.

What does this mean for the entire DC Cinematic Universe? We will have to wait and see how things pan out. But one thing is for sure, WB has put too many eggs in DC’s basket to let it fail now.


to play defense next year in the 41 districts that Democrats flipped from Republican control in 2018. At the same time, the committee has identified 33 GOP-held seats that it is looking to pick up in 2020.

Some Republicans have expressed concerns about the NRCC’s leadership and 2020 strategy, questioning the committee’s no-holds-barred messaging tactics, as well as its ability to recruit top-tier candidates after the group’s recruitment chair, Rep. Susan Brooks Susan Wiant BrooksBipartisan lawmakers call for broadband expansion to eliminate inequities The Hill's Morning Report - Sponsored by Facebook - GOP closes ranks to fill SCOTUS vacancy by November The Hill's Morning Report - Sponsored by Facebook - Trump, GOP allies prepare for SCOTUS nomination this week MORE (R-Ind.), announced her retirement last week.various providers to ensure that IBD-specific laboratory, endoscopic and imaging studies are indicated to evaluate whether the patient has a recurrence or a treatment-related adverse effect ([**Table 1**](#gow032-T1){ref-type="table"}). Table 1.Various aspects of managing inflammatory bowel disease (IBD) in remissionPrevention of IBD recurrences, cancer or other late effectsSurveillance for disease spread, recurrence or cancer developmentAssessment of medical, postsurgical and psychosocial effectsIntervention for consequences of IBD and its treatmentsCoordination between gastroenterologists and primary care providers to ensure meeting all health needs

Information technology may improve the quality, safety, efficacy and coordination of care among the various providers delivering care to IBD patients in remission and may also help engage patients in accessing their health records and monitoring their disease and its therapy. Electronic reminders can optimize blood count and liver panel


generally does not preclude initiation of immunosuppressive regimen \[[@gow032-B76],[@gow032-B77]\].

### Psychosocial issues

IBD is a chronic illness involving multiple clinic visits and hospitalizations and, in many patients, one or more surgeries. As such, it impacts psychosocial aspects of the patient's life and in turn affects quality of life, adherence to treatment or disease course. In a recent cross-sectional study of IBD patients, a higher level of perceived stress was found to be a strong predictor of lower health-related quality of life and lower adherence to provider recommendations \[[@gow032-B78]\]. Active disease is known to cause episodes of anxiety and depression, but disease-related concerns and worries are present even in patients in remission \[[@gow032-B79]\]. There is a need for interdisciplinary evidence-based guidelines to provide specific recommendations on the etiology and management ofan ostomy nurse may improve outcomes and reduce complications \[[@gow032-B126]\].

### Extra-intestinal manifestations

Several extra-intestinal manifestations of IBD may occur while patients are in remission, and they require early recognition and treatment. Pyoderma gangrenosum or deep purulent ulcerations (usually on the legs) require systemic steroids or TNF antagonists \[[@gow032-B127]\]. In a similar fashion, uveitis manifesting as eye pain and redness usually does not parallel the activity of IBD and requires prompt evaluation by an ophthalmologist and intervention using topical or systemic steroids \[[@gow032-B128]\]. Although PSC may present with fatigue and pruritus, it is often detected in the context of evaluating abnormal (predominantly cholestatic) liver tests in patients with UC and less often CD \[[@gow032-B129]\]. Patients with PSC require yearly screening for gallbladder and hepatobiliary and pancreatic cancer by ultrasound or


- $160RIT Faculty/Staff/Alumni (1 per valid ID) - $140Youth (12 and under) – $85RIT Student (1 per valid ID) - $65Adults - $210RIT Faculty/Staff/Alumni- $185Student (1 per valid ID) - $185Youth (12 and under) – $120Adults - $465RIT Faculty/Staff/Alumni- $430Student (1 per valid ID) - $430Youth (12 and under) – $360Adults - $12RIT Faculty/Staff/Alumni - $10 (four ticket limit per valid RIT ID)Youth (12 and under) – $6RIT Students - $5 (four ticket limit per valid RIT ID)Adults - $15RIT Faculty/Staff/Alumni - $13 (four ticket limit per valid RIT ID)Youth (12 and under) – $8RIT Student - $5Adults - $32RIT Faculty/Staff/Alumni/Student - $30 (four ticket limit per valid RIT ID)Youth (12 and under) – $24Adults - $15Faculty/Staff/Alumni (purchased on RIT Campus) - $13 (one ticket limit per validRIT ID)External Students - $9RIT Students (purchased on RIT Campus) - $6 (one ticket limit per valid RIT ID)Children 5 and under - $5Adults - $55RIT Staff/Faculty/Alumni - $45Youth (12 and under) - $35Students – Free (one ticket per valid RIT ID)Adults - $5RIT Staff/Faculty/Alumni - $4Youth (12 and under) - $3RIT Students – Free (one ticket limit per valid RIT ID)


alternatives are terrible (say a bus that takes more than twice as long as driving, like currently exists for much of Auckland) then prices are going to have to be really high before people start changing the way they travel. This is really problematic because….

, there’s clearly a cost to them in needing to travel via a different route or mode, or at a different time. Otherwise they would have been travelling this other way in the first place. A successful pricing scheme will be one that gets enough people to change at the lowest possible price. Importantly, the better their alternatives are (which could mean available public transport that’s nearly as fast as driving, or an employer who allows flexible work times so they don’t need toa prime number?
True
Is 7103 a composite number?
False
Is 7453 a composite number?
True
Is 54217 composite?
False
Is 3401 a prime number?
False
Is 7349 a composite number?
False
Is 125141 composite?
False
Is 18947 a composite number?
False
Is 51383 a composite number?
False
Is 46601 a composite number?
False
Is 1718809 composite?
True
Is 137369 a prime number?
True
Is 977629 composite?
False
Is 3349 a composite number?
True
Is 91571 a prime number?
True
Is 115405 a composite number?
True
Is 21269 a composite number?
False
Is 1433062 a composite number?
True
Is 8357 prime?
False
Is 410317 a prime number?
True
Is 84761 prime?
True
Is 533879 composite?
False
Is 6521 a prime number?
True
Is 7033 composite?
True
Is 269017 composite?
True
Is 100447 prime?
True
Is 3407 a composite number?
False
Is 319259 a composite number?
False
Is 156019 prime?
True
Is 8651 prime?
False
Is 1250647 prime?
True
Is 459089 a composite number?
False
Is 38543 a prime number?
True
Is 202355 prime?
False
Is 359341 composite?
True
Is 24901 prime?
False
Is 175601 a composite number?
False
Is 25837 a composite number?
True
Is 302329 composite?
False
Is 8419 a composite number?
False
Is 864337 a prime


Marine Le Pen's top aide and and architect of her far-Right Front National's "detoxification" drive has stepped down in what he called a "terrifying" victory for hardliners.

Florian Philippot, one of Ms Le Pen's closest allies, said he was leaving the party a day after she stripped him of his role as FN chief strategist while allowing him to retain his title of vice president.

"They told me that I was vice-president of nothing," Mr Philippot, 35, told France 2. "Listen, I'm not into being ridiculed. I have no taste for doing nothing, so of course I am leaving the Front National."

Since its disappointing performance in both the May presidential and June parliamentary elections Mr Philippot said the FN was showing signs of taking "an absolutely terrifying backward slide" toareas of the university campus and invited them to participate. In the latter half of the study, a snowball approach was used. The snowball approach was adopted due to problems with identifying and recruiting postgraduate students. They constitute a considerably smaller percentage of the total student body, often are enrolled externally and attend classes in the late afternoon/evening. Students were classified on the basis of their enrolment status: undergraduate vs. postgraduate, and domestic vs. international. We aimed to recruit a sample of students from each classification and hence we firstly screened the student to identify their enrolment status. Students enrolled in the bachelor of medicine were excluded as it was assumed they would not be representative of the general student body, and would have had more exposure to


it gets colder...." (International postgraduate student)

Many of the participants were unable to accurately define what pandemic influenza was. While avian flu or SARS were mistaken as examples of past pandemics, almost all participants were able to associate the recent "swine flu" situation as an example of a pandemic event. In comparison to seasonal influenza and colds, participants generally perceived pandemic influenza as being more serious. Pandemic influenza was associated with increased numbers of medical consultations/hospitalizations and a higher mortality rate. However, there were a few sceptical participants who were doubtful about the actual disease impact and felt that it was only "promoted" as being serious by the government and the media.

Young children and the elderly were nominated as being the most vulnerable groups during a pandemic outbreak dueto their 'sub-optimal immune systems'. Participants believed that children were less conscious about hygiene and were therefore more likely to be exposed to other infected children or contaminated objects in a school environment. On the other hand, teenagers and young adults (20s-30s), the 'physically and socially healthy' and the 'well educated', were considered to be at lowest risk of contracting pandemic influenza.

In regards to differences in risk between racially or culturally diverse groups, one participant commented that people or cultures that have frequent proximate interaction with each other were at risk of contracting the disease during pandemic. While another suggested that in countries where there are higher levels of respect for traditional medicines over western medicines, people may also be at risk. Amongst the international students it was


outbreak caused a substantial burden and challenge to the university health care system \[[@B15]\]. In Japan, Uchida et al. reported that the infection rate among university students they surveyed ranged from 4.3 % to 15.5 % during the 2009 pandemic \[[@B16]\]. The authors suggested that continued exposure to sick individuals and disease transmission occurred during the pandemic, mainly through university club activities.

While our participants were knowledgeable about the modes of transmission of influenza, very few were able to accurately describe what 'pandemic influenza' actually meant. The participants had heard of 'swine flu', however only a few demonstrated a high level of knowledge around how it originated. There was a lot of confusion around the role that animals play in regard to 'pandemics'. Unconfirmed beliefs and misconceptions regarding pandemicit may have resulted in an over-reporting of infection control behaviours to avoid embarrassment or judgement; (2) recall bias: some questions in the interview guide required participants to recall their past experiences during the 2009 H1N1 pandemic, therefore recalling errors may have occurred; (3) representation: as the study was undertaken one year after the pandemic, the responses received may not represent the attitudes that participants held during the pandemic; (4) participation rate was low.

Communicating to students effectively about the spread of influenza and the need to adopt preventative measures on a large campus presents a challenge. University officers need to find a balance between promoting and educating, while trying not to incite unnecessary fear. In the event of prolonged public health threats, such as infectious disease disasters, online


if an authorization for that application
        /// doesn’t already exist for the user; otherwise, it fails.
        ///
        /// <remarks>
        /// This method requires authentication.
        /// See the API documentation for more information.
        /// </remarks>
        /// <param name="clientId">Client Id of the OAuth application for the token</param>
        /// <param name="clientSecret">The client secret</param>
        /// <param name="twoFactorAuthenticationCode">The two-factor authentication code in response to the current user's previous {
            Ensure.ArgumentNotNullOrEmptyString("clientId", clientId);
            Ensure.ArgumentNotNullOrEmptyString("accessToken", accessToken);

            return _client.CheckApplicationAuthentication(clientId, accessToken)
                .ToObservable();
        }

        ///
        /// Resets a valid OAuth token for an OAuth application without end user involvement.
        ///
        /// <remarks>
        /// This method requires authentication.


“Widespread poverty, low educational attainment, high rates of community and interpersonal violence, high rates of alcohol-related deaths and suicide, poor physical health, and corroded family and community relationships.” (Shattered Hearts)

In the following video, Rose Henry, an Aboriginal community consultant from the Coast Salish territory, addresses why Aboriginal people are uniquely vulnerable to human trafficking in Canada.

Vulnerabilities of Aboriginal Peoples

In Canada, research has identified particular patterns in the way in which vulnerable Aboriginal women and girls are exploited:

According to Dr. Mark Totten, in research undertaken for the Native Women’s Association of Canada, “Sexual trafficking of Canadian Aboriginal girls and women is most common within the borders of Canada, particularly in the Prairie provinces. Trafficking networks are found in major cities (such as Vancouver, Winnipeg, Regina, Edmonton and Calgary) andunderlying elements in the various methods that traffickers use to force Aboriginal girls into sex trafficking,” and that recruitment occurs over the Internet, at airports, schools, bars, by traffickers posing as boyfriends and by other girls who have “no choice but to agree to the wishes of the trafficker due to fear, or in some cases, to meet their survival needs.” By forcing them to hitchhike, the lack of transportation options in some smaller and more rural communities also makes young Aboriginal girls “vulnerable to sexual exploitation.”

Lack of transportation options in some smaller and more rural communities means young Aboriginal girls hitchhike more, which may make them vulnerable to sexual exploitation.

In the following video clip from the documentary Enslaved and Exploited: The Story of Sex Trafficking in Canada,


Canadian experts, including Anupriya Sethi, discuss domestic trafficking of Aboriginal girls and women for the purpose of sexual exploitation.

Video clip from: Enslaved and Exploited: the Story of Sex Trafficking in Canada

Human Trafficking in the North

Human Trafficking happens everywhere in Canada, including Nunavut, the Northwest Territories, and the Yukon. Helen Roos, Chair of the Ottawa Coalition to End Human Trafficking and a researcher for human trafficking issues in Northern Canada, states:

Permanent link to page:

Help us improve gov.bc.ca

*Don't provide personal information . Comments will be sent to 'servicebc@gov.bc.ca'

Enter your email address if you would like a reply:

The information on this form is collected under the authority of Sections 26(c) and 27(1)(c) of the Freedom of Information and Protection of Privacy Act to help us assess and respond to your enquiry.parsed data into a CSV file
This is my attempt at parsing and exporting the data:
from urllib.request import urlopen as uReq
from bs4 import BeautifulSoup as soup
import csv

my_url = 'http://thailove.net/bbs/board.php?bo_table=ent'

uClient = uReq(my_url)
page_html = uClient.read()
uClient.close()

page_soup = soup(page_html, "html.parser")

containers = page_soup.findAll("td",{"class":"td_subject"})
for container in containers:
    subject = container.a.contents[0]
    print("subject: ", subject)

with open('ThaiLove.csv', 'w') as f:
csv_writer = csv.writer(f)
for subject in containers:
        value = subject.a.string
        if value:
                csv_writer.writerow([value.encode('utf-8')])

A:

A few problems. First, you don't encode here. So it should be:
containers = soup.findAll("td",{"class":"td_subject"})
for container in containers:
    subject = container.a.contents[0]
    print("subject: ", subject)

import csv

with open('ThaiLove.csv', 'w') as


f:
    csv_writer = csv.writer(f)
    for subject in containers:
        value = subject.a.contents[0]
        if value:
            csv_writer.writerow([value])

all without encoding in UTF-8. Which gives me:
"\n                    미성년자도 이용하는 게시판이므로 글 수위를 지켜주세요.                    "\n"\n                    방꺽너이 방야이운하 수상보트를 타고 가서 볼만한 곳..                   "\n"\n                    방콕의 대표 야시장 - 딸랏롯파이2                    "\n"\n                    공항에서 제일 가까운 레드썬 마사지                    "\n"\n

and so on.
Second, you seem to be writing the wrong thing to your csv. You want to essentially copy the


have minimal loss when transmitting an input signal from one port to the other. The conventional RF circulator 100 is typically packaged with a metal case (not shown in FIG. 1).
A common use of an RF circulator is to provide connectivity to an antenna. For example, an input signal is from a transmitter, which outputs at a port coupled to an antenna and isolated at a receiver port. As another example, an input signal from an antenna outputs at a port coupled to a receiver and isolated at the transmitter port.
There are a number of factors that determine the operation of an RF circulator including frequency band (or bandwidth), insertion loss, isolation, power, and package type. The bandwidth is the frequency range over which the device can operatepolarity. I know polarity makes a difference on the HD and power LEDs, but not on the power or reset pins. Not sure about the speaker though.

thanks. I thought it was right, but wasn't sure. when I was putting the board in i wasn't sure what those tabs were or what to do with them; whether I should bend them back or what. have read a million times how important is was the MB not touch the case, so didn't want to force things. it's funny though, did have trouble starting it. when I got it all hooked up and hit the power button nothing happened, thought I was going to cry, lol. couldn't figure out what I did wrong. even took a PSU out of another computer


doctors' representative organisations.

Usage Note: Some people insist on maintaining a distinction between the words healthy and healthful. In this view, healthful means "conducive to good health" and is applied to things that promote health, while healthy means "possessing good health," and is applied solely to people and other organisms. Accordingly, healthy people have healthful habits. However, healthy has been used to mean "healthful" since the 1500s, as in this example from John Locke's Some Thoughts Concerning Education: "Gardening ... and working in wood, are fit and healthy recreations for a man of study or business." In fact, the word healthy is far more common than healthful when modifying words like diet, exercise, and foods, and healthy may strike many readers as more natural in many contexts. Certainly, both'LTVCategory',
        label: 'LTV Category',
        classes: "hidden-xs",
        labelClasses: "hidden-xs",
        width: 120,
        width: 165
      },

      {
        name: 'MaxLoanAmt',
        label: 'MaxLoanAmount',
        width: 165,
        sorttype: 'number',
        align: "right",
        formatter: 'currency',
        formatoptions: {


autowidth: true,
    height: 'auto',
    forceClientSorting: true,
    sortname: "Symbol",
    footerrow: true,
    caption: "Collateral Value Valuation as of: " + mmddyyyy + "",

    loadComplete: function() {
      var $self = $(this),
        sum = $self.jqGrid("getCol", "Price", false, "sum"),
        sum1 = $self.jqGrid("getCol", "MaxLoanAmt", false, "sum");
      //ltvratio =  $self.jqGrid("getCol","LTVRatio:addas", "Aved Loan Amount");
      $self.jqGrid("footerData", "set", {
        LTVCategory: "Max Approved Loan Amount:",
        Price: sum,
        MaxLoanAmt:      alert(res);
                }
            });*/
          }
        }
      });
    }
  });
  /***********************/
  $("#output").jqGrid('filterToolbar', {
    stringResult: true,
    searchOnEnter: false,
    defaultSearch: "cn"
  });

  $(window).on("resize", function() {
    var newWidth = $("#output").closest(".ui-jqgrid").parent().width();
    $("#output").jqGrid("setGridWidth", newWidth, true);
  });
});

A:

The following CSS rule of jQuery UI will be applied to the disabled rows:
.ui-state-disabled, .ui-widget-content .ui-state-disabled,
.ui-widget-header .ui-state-disabled {
    opacity: 0.35;


bone allografts at the QBB using method VDmax 15-ISO 11137-2: 2006 (ISO 11137-2e, Procedure for method VDmax 15 for multiple production batches. Sterilisation of health care products - radiation - part 2: establishing the sterilisation dose, 2006; ISO 11137-2f, Procedure for method VDmax 15 for a single production batch. Sterilisation of health care products - radiation - part 2: establishing the sterilisation dose, 2006). 30 femoral heads, 40 milled bone allografts and 40 structural bone allografts manufactured according to QBB standard operating procedures were used. Estimated bioburdens for each bone allograft group were used to calculate the verification doses. Next, 10 samples per group were irradiated at the verification dose, sterility was tested and the number of positive tests of sterility recorded. If the number of positive samplesthan just the
categories cited in the release, the average annual return for it was 3.074
percent, compared to the Standard and Poor’s 500 Index (which is based on
equities) return of a 4.143 percent. In other words, the fund would have done
better by plowing everything into an index fund representing the S&P 500.

12.9.12

With news that most of
Louisiana’s charity hospitals may get downsized confirms the move to
dismantle the system as it is has come to the stage of a realistic alternative
future, also bringing big change to some other related areas of policy, and not
a second too soon to benefit the state.

Spurred by the sudden
loss of a good chunk of its Medicaid reimbursement from the federal
government – the vast majority of these public hospitals’ business is paid for
that way, making Louisiana public


other being the Associated Professional Educators of
Louisiana, which has no collective bargaining units established and
declines to identify itself only as a union saying it is a broader professional
organization).

9.9.12

If Louisiana legislators remain invested in the same ideology that has
spawned the hundreds of tax exceptions, not a single constructive thing will
emerge from the effort.

Last week, the Revenue Study
Commissionreviewed a number of these in an effort to parse out whether
policy as it exists in this regard optimally forgoes revenues because of these
exceptions. Part of the exercise allowed arguments, particularly from current beneficiaries,
stating cases as to why their breaks, some of which on the surface seem very
questionable, should continue.

And so we got from them arguments like Lt. Gov. Jay Dardenne’s, who
oversees arts policy as part of his portfolio, defending the sales tax
exemptionresidents — including those who have sued the city unsuccessfully — have questioned why the de Blasio administration chose community districts. The answer is this: Some neighborhoods share ZIP codes but are in different community districts, and it is through districts, not neighborhoods, that city services are generally delivered.

Eric Adams, the Brooklyn Borough president, has argued that someone who becomes homeless in working-class Crown Heights could live in a shelter in nearby, wealthier Park Slope without feeling displaced.

Wakefield More people became homeless here than are sheltered here Pelham Parkway Bronx High Bridge More people are sheltered here than became homeless here Soundview East Harlem Upper West Side 2,000 1,000 500 Midtown Elmhurst Floral Park Manhattan Lower East Side Queens Bedford Stuyvesant South Jamaica Brownsville Sunset Park Brooklyn Flatbush


of Staten Island, northeast Queens and Bay Ridge, Brooklyn, produce homelessness but have no shelters at all. And they could be selected as locations for new shelters under the mayor’s plan. Staten Island has more than 1,200 homeless people, but only one shelter with space for 135 residents.

Bronx Number of people who became homeless in a ZIP code without a shelter Inwood Parkchester 500 Areas with no shelters 100 5 Lincoln Square Manhattan Chelsea Queens Village Queens Glendale Newly opened shelters under the mayor’s plan St. Albans Red Hook Laurelton Brooklyn Arlington Bay Ridge Emerson Hill Bath Beach Grasmere Staten Island Coney Island Number of people who became homeless in a ZIP code without a shelter Bronx Man. 500 Queens 100 5 No shelters Brooklyn Staten Island Bronxlocal commercial plantation in Guangzhou, China. Fruits were sampled on the 16^th^, 21^st^, 26^th^, 30^th^, 35^th^, 40^th^ and 49^th^ day after artificial pollination (DAAP). The sample dates were selected to provide a set of samples covering pulp color changes in the fruit. At each sampling, internal fruit tissue (pulp tissue) from three fruits from three different plants were sampled, sliced, and frozen in liquid nitrogen immediately. Samples were stored at −80 °C for future analysis.

Betalain quantification
-----------------------

The level of betalains in the pulp tissue of each sample was determined as previously described.^[@bib10]^ Betalains were isolated from 0.5 g pulp with 5 mL 80% aqueous methanol (v/v) solution. The amount of betacyanin and betaxanthin in the solutions were measured by spectrophotometry (Infinite M200, Tecan Co.) at 538 and 483 nm, respectively, and reported as


mg/100 g fresh pulp.

Gene isolation and sequence analysis
------------------------------------

Total RNA was extracted from pitaya pulp samples using the Quick RNA Isolation Kit (Huayueyang, Beijing, China) following manufacturer's instructions. RNA quality was assessed by gel electrophoresis and spectrophotometry. The extracted RNA was used as template to synthesis cDNAs using a PrimeScript RT reagent Kit with gDNA Eraser (TaKaRa, shiga, Japan).

On the basis of the generation of a previous RNA-seq database,^[@bib10]^ a WRKY TF was found to be significantly up-regulated during pulp coloration. As this WRKY displays high degree of sequence homology to *Arabidopsis thaliana* WRKY44, thus it was termed as *HpWRKY44*. *HpWRKY44* was cloned (primers are listed in [Supplementary Table S1](#xob1){ref-type="supplementary-material"}), sequenced and the resulting sequence was queried against the NCBI database in order to identify homologous genes. The theoretical isoelectricOn January 28, Maryland Attorney General (AG) Doug Gansler announced a new unit in his office dedicated to online privacy enforcement and policy. The AG stated that the new unit will (i) monitor companies to ensure they are...more


extradited to the United States and the inevitable supermax, journalism will be incarcerated, too.

"Who will then dare to expose anything of importance, let alone the high crimes of the West? Who will dare publish 'Collateral Murder'? Who will dare tell the public that democracy, such as it is, has been subverted by a corporate authoritarianism from which fascism draws its strength.

"Once there were spaces, gaps, boltholes, in mainstream journalism in which mavericks, who are the best journalists, could work. These are long closed now. The hope is the samizdat on the internet, where fine disobedient journalism is still practised. The greater hope is that a judge or even judges in Britain's court of appeal, the High Court, will rediscover justice and set him free. In the meantime, it'stexting your mum? I suppose “attempting to take a photo” is a crime that could catch somebody arriving with a large SLR, tripod and several mounted lighting boxes, but none of those appeared to have made it into the public gallery.

"Baraitser did not state whether it was a criminal offence to publish a photograph taken in a courtroom (or indeed to attempt to publish a photograph taken in a courtroom). I suspect it is. Anyway Le Grand Soir has published a translation of my report yesterday, and there you can see a photo of Julian in his bulletproof glass anti-terrorist cage. Not, I hasten to add, taken by me.

Political extradition

"We now come to the consideration of yesterday’s legal arguments on the extradition request itself. Fortunately, these are basically


the United States was in the very definition of a political offence in all the authorities."[8]

Related Documents

Please help keep this site running by donating or spreading the word about our Patreon page. As of 17 September, our 19 Patrons are giving £67/month, which is 2/3 of our webhosting bill.

then scanned with in vitro-based radiography intended to replicate the dual-energy X-ray absorptiometry technique. All parameters were measured regionally around the circumference of the femoral neck, allowing examination of spatial variability within the cortical bone. Fractured tissue was less resistant to indentation in the thinner superolateral segment compared to other segments and other groups. BMD around the fractured femoral necks appeared more consistent than that of nonfractured tissue, where BMD was reduced in the superolateral segment for the other groups. Cortical bone was thin in the superolateral segment for all groups except for the osteoarthritic group, and was thicker in the inferomedial segment for both osteoarthritic and fractured groups, resulting in the largest variation in buckling ratio (ratio of cortical bone diameter to cortical bone thickness) around the


up to be even more flawed than the original election.

Rather than postpone the new election or address his complaints, the IEBC said Wednesday that the vote would go forward and would include six minor candidates.

Previously, the rerun was to have involved only Kenyatta and Odinga. With none of the other candidates having garnered more than 1 percent of the vote in August, the incumbent was expected to notch an easy win in the new election.

On Tuesday, Kenyatta's Jubilee Party, which holds a majority in parliament, passed amendments to the electoral law that appeared designed to legalize many of the voting irregularities that prompted the high court to toss out the original election results.

One amendment says that if any candidate were to pull out of an election rerun involvingSummoned to perform a Special Mission. It is not just a job. I firmly believe that I am being called by God as His Foolish and Humble ‘Knowledge Servant’ to at least TRY to save Mankind – – BEFORE it is TOO LATE!” For this reason, Dr. Layman likes to refer to his Spiritual Self by the nickname, “Poor Dad.” His Spiritual Self (“Poor Dad”) has repeatedly confessed that, “My Heart, it is breaking! And my Soul, it is aching! For I have Foreseen the End of Mankind!”

Dr. Layman is the author of seven books – – 3 textbooks and 4 trade books. All of his publications (except for the first book) apply the unique educational principle that he invented and named, ‘Compu-Think’. Compu-Think is a contraction that


means, “Computer-like” ways or modes of human “thinking.” (Compu-Think was formally defined by Dr. Layman in the FOREWORD he wrote for the book, CONCISE ENCYCLOPEDIA OF ROBOTICS, written by Stan Gibilisco, 2003). Compu-Think asks us to consider this important question: “Can we learn to think or at least process information somewhat like computers do, but without always having to actually USE computers?” Dr. Layman posits that Compu-Think could help us reduce our modern tendency towards hypercomputerization – an “excessive” (hyper-) use of computers.

Dr. Layman believes that Barack Obama, President of the United States, is largely to blame for this new Grave, Quickly- Emerging Robo-Danger. He has arrogantly and unwisely bypassed any consultation with the U.S. Congress and, using his own Executive Privilege as President, created the 2011 NationalQ:

Mobile group voice chat server

For a hobby project of me i'm looking to implement a group voice chat feature. Pretty straight forward: I'm running a server to which multiple clients (mobile) can connect to. Some Clients are in the same "group" and I want them to have an audio chat feature.
I already set up a UDP server client with C# to which clients can connect to. I have successfully implemented audio distribution between clients over the server and the rudimentary features are working pretty well.
I am not sure if i'm going in the right direction with this approach though.
I'm stuck with the implementation of mixing the different voices for example (two people talking simultaneously and another is listening to both). I don't really know how I can mix


it was a bit of a mess when they crossed up both accounts; discontinued some services on the new one and thought they had changed the old one, etc. Took several months to clean up.

With regard to how they handle things it appears that it's really a local issue. Often Comcast acquired a local cable provider at some point and just kept their policies intact (as long as they benefited Comcast). The inconsistencies in service, quality, support, etc. are legend. I can't really complain about our service though. They've been fairly decent throughout. Too bad they've boosted our "Triple Play" rates over $200/mo. in one year. We're going to end up with about the same services with more HD, better PQ and faster broadband for almost half thecurrent offer of $150 cash back after the first 30 days. It's not cheap by any means, but it's everything we wanted and I can live with that.

Now I have to break the news to Comcast. Such is life. I'm guessing they'll try to retain me, but my mind is made up!

Wish me luck!

Click to expand...

Rich,

I hope you have the same luck I did. Almost 3 weeks and (knock on wood) no problems. I just looked at my first bill online and it seems to be right, so that's the last hurdle. Of course, I turned my Comcast stuff in on 3/30 but they haven't been out to the tap to turn it off yet, so they still consider me a customer. According to the guy who called


VZ's is 20/5 I'm a little worried about an actual cut in speed now. Comcast used to have a download "blast" where the speed was higher for the first 10MB and then throttled back. I can't find any info about that now and wonder if that's still the case or if they opened up the pipe to compete w/VZ?

Just downloading a large file from any old site isn't a good measure. So I guess I need to find a test server that will allow a sustained download larger than the typical test sites to see if it eventually falls off.

Anyway, just wondering what you (or anyone else) were seeing. It won't deter me from switching but I was hoping for as fast or faster broadband than what Irouter). From what I've seen, they are using a Westell in the great Northwest, and some have claimed it is better the Actiontec deployed here in former Bell Atlantic territory. It does seem to have some issues with VPN's, so if you don't need it for their STB's you can avoid it altogether. If you do need it, and can easily connect your router to the ONT with ethernet, use the Westell in bridge mode to your router for MoCA for the STBs. Reports of interference by the MoCA channels have really decreased and that setup would only use the LAN channel, no WAN channel needed. Another method would be to use a NIM 100 (if the installer has one) from an ethernet port on your router to


the client open as many connections as it wants, and then set them all the files downloading simultaneously, and you'll be getting a METRIC TON of peers. I think I remember seeing at least 15 mbps down at one time using that technique.

BTW... I'm not sure when I last saw pixellation. I'm considering dropping my attenuation down form 6 to 3dB to see how that works.

Click to expand...

I pretty consistently get within 5% of the advertised speeds as well. I've done a few speed tests for various neighbors that have FiOS, and we're all getting right at the same speed.

Knock on wood, but I haven't had any pixellation problems in quite a while. I think they really have been working on the problem.

Bought a THD at Sears, special43.5% were married couples living together, 10.6% had a female householder with no husband present, 4.4% had a male householder with no wife present, and 41.5% were non-families. 29.2% of all households were made up of individuals and 10% had someone living alone who was 65 years of age or older. The average household size was 2.41 and the average family size was 2.97.

The median age in the city was 28.3 years. 20.9% of residents were under the age of 18; 23.7% were between the ages of 18 and 24; 23.4% were from 25 to 44; 20.5% were from 45 to 64; and 11.5% were 65 years of age or older. The gender makeup of the city was 48.4% male and 51.6% female.

2000 census
As of the census of


AllocateInputs() method is called before formatting the message as the Message Formatting section is essentially deserialising the given message into a set of method arguments to be passed on to the appropriate operation and the invoker's AllocateInputs() method specifies how many parameters are expected.
The part that throws me is the inversion of sequence between Message Inspector and Operation Selector. It sounds logical to me for Message Inspectors to be run through first as they act on the message whereas Operation Selector determines which service operation the message is targeted for.
Questions:

Is that due to different versions or releases of WCF?
Is this because WCF does not actually specify extensibility points execution sequence?

Reference pages:
Extending WCF to support custom data formats - Zulfiqar's weblog
Extending WCF with Custom Behaviours - MSDN Serviceinline superlu_options_t& options() { return m_sluOptions; }

    /** \brief Reports whether previous computation was successful.
      *
      * \returns \c Success if computation was succesful,
      *          \c NumericalIssue if the matrix.appears to be negative.
      */
    ComputationInfo info() const
    {
      eigen_assert(m_isInitialized && "Decomposition is not initialized.");
      return m_info;
    }

    /** Computes the sparse Cholesky decomposition of \a matrix */
    void compute(const MatrixType& matrix)
    {


{
      init();
      Base::compute(matrix);
    }

    ~SuperLU()
    {
    }

    /** Performs a symbolic decomposition on the sparcity of \a matrix.
      *
      * This function is particularly useful when solving for several problems having the same structure.
      *
      * \sa factorize()
      */
    void analyzePattern(const MatrixType& matrix)
    {
      m_info = InvalidInput;
      m_isInitialized = false;
      Base::analyzePattern(matrix);
    Base::init();

      set_default_options(&this->m_sluOptions);
      m_sluOptions.PrintStat        = NO;
      m_sluOptions.ConditionNumber  = NO;
      m_sluOptions.Trans            = NOTRANS;
      m_sluOptions.ColPerm          = COLAMD;
    }

  private:
    SuperLU(SuperLU& ) { }
};

template<typename MatrixType>
void SuperLU<MatrixType>::factorize(const MatrixType& a)
{
  eigen_assert(m_analysisIsOk && "You must first call analyzePattern()");
  if(!m_analysisIsOk)
  {
    m_info = InvalidInput;
    return;
  }


0)
    {
      int lastId = m_u.outerIndexPtr()[j+1]-1;
      eigen_assert(m_u.innerIndexPtr()[lastId]<=j);
      if (m_u.innerIndexPtr()[lastId]==j)
        det *= m_u.valuePtr()[lastId];
    }
  }
  if(PermutationMap(m_p.data(),m_p.size()).determinant()*PermutationMap(m_q.data(),m_q.size()).determinant()<0)
    det = -det;
  if(m_sluEqued!='N')
    return det/m_sluRscale.prod()/m_sluCscale.prod();
  else
    return det;
}

#ifdef EIGEN_PARSED_BY_DOXYGEN
#define EIGEN_SUPERLU_HAS_ILU
#endif

#ifdef EIGEN_SUPERLU_HAS_ILU

/** \ingroup SuperLUSupport_Module
  * \class SuperILU
  * \brief A sparse direct \b incomplete LU factorization and solver based on the SuperLU library
  *
  * This class allows to solve for an approximate solution of A.X = B sparse linear problems via an incomplete LU factorization
  * using the SuperLU library. This class is aimed to beb.cols();
  eigen_assert(size==b.rows());

  m_sluOptions.Trans = NOTRANS;
  m_sluOptions.Fact = FACTORED;
  m_sluOptions.IterRefine = NOREFINE;

  m_sluFerr.resize(rhsCols);
  m_sluBerr.resize(rhsCols);

  Ref<const Matrix<typename Rhs::Scalar,Dynamic,Dynamic,ColMajor> > b_ref(b);
  Ref<const Matrix<typename Dest::Scalar,Dynamic,Dynamic,ColMajor> > x_ref(x);

  m_sluB = SluMatrix::Map(b_ref.const_cast_derived());
  m_sluX = SluMatrix::Map(x_ref.const_cast_derived());

  typename Rhs::PlainObject b_cpy;
  if(m_sluEqued!='N')
  {
    b_cpy = b;
    m_sluB = SluMatrix::Map(b_cpy.const_cast_derived());
  }

  int info = 0;
  RealScalar recip_pivot_growth, rcond;

  StatInit(&m_sluStat);
  SuperLU_gsisx(&m_sluOptions, &m_sluA,
                m_q.data(), m_p.data(),
                &m_sluEtree[0], &m_sluEqued,


  adapter = new TemplateContextAdapter(request, context);
    }

    @Test
    public void newInstance() {
        try {
            new TemplateContextAdapter(null, null);
            fail();
        } catch (IllegalArgumentException e) {
            assertThat(e, exception("request"));
        }

        try {
            new TemplateContextAdapter(request, null);
            fail();
   In my post The Origins of Libertarian IP Abolitionism, I discussed the origins of the modern libertarian anti-IP movement. I’ve learned a lot more about the antecedents and history of all this from teaching the Mises Academy course “Rethinking Intellectual Property: History, Theory, and Economics.” This history is very interesting. It seems to me we can mark at least four periods of significant and vigorous debate about IP that included strong arguments against IP, which I set forth below.

1.The Anti-patent movement from 1850-1873

Machlup lays out four historical periods leading to the modern patent systems of the world:

Early History (pre-1624)

Spread of the Patent System (1624-1850)

Rise of the Anti-patent movement (1850-1873)

Victory of the Patent Advocates (1873-1910)

Interestingly, many of the same argument, pro- and con, that were made then, have been


in “The Death Throes of Pro-IP Libertarianism.”

The case against IP is today especially clear to Austrian-, anarchist-, and left-libertarians, and has intensified and grown significantly in recent years, and shows no sign of abating. The libertarian IP proponents are on the ropes and dwindling in numbers, or so it seems to me.

Thus, in addition to the younger libertarian IP opponents from Phase 3, above (McElroy and Palmer), there are today a large number of libertarian and free market/semi-libertarian opponents of IP, including: Roderick Long, Kinsella, Jeff Tucker, Boldrin and Levine, Julio Cole, Karl Fogel, Nina Paley, David Koepsell, Bertrand Lemmenicier, Sheldon Richman, Kevin Carson, Tom Bell (many of whom are members of the C4SIF’s advisory board), and many others (again, see the C4SIF Resources page for link toQ:

Graph coloring register allocator

For my compiler course I'm building a register allocator based on graph coloring for MIPS architecture. I'm following Muchnick's treatment on the same for my implementation.
Muchnick has been a little fuzzy about how to treat arguments of function in these allocators.
I've made a few assumptions and thought I'd clarify the same.

There is this step to convert to lower level IR from middle level IR. Nested function calls have not been handled. My idea is to scan the function call from right to left and lay down IRs for the innermost calls outward. This way I can use the MIPS calling convention of assigning the first few arguments to argument registers and the remaining to stack with minimum amount of spills (just 1).
Register coalescing treatment


rest of the app layout and UI.

, routing is not centralized anymore instead it becomes a part of the rest of the app layout and UI. Browser specific routing components live in react-router-dom instead of react-router so imports need to be changed to be from react-router-dom package.

instead of so imports need to be changed to be from package. Introducing new components such as BrowserRouter and HashRouter for specific use cases (see below).

and for specific use cases (see below). No more use of {props.children} for nesting components in v5 React Router.

for nesting components in v5 React Router. React Router v3 routing rules were exclusive meaning only one route will be matched at one time. For v5, routing rules are inclusive meaning multiple routes can be matched and then rendered.

React-router-dom      e.style.display = 'none';
        else
            e.style.display = 'block';
    }
    //-->
</script>`

A:

you should do that in same span to view it in same line
try this

 API Access:

  ********API_KEY


Celebrity mugshots: the good, the bad and the ugly

By Chron.com staff

From world leaders to Hollywood actors, check out these famous mugshots.

Getty Images

Jeffrey Donovan

57of77

"Burn Notice" actor Jeffrey Donovan poses for a photo for the Miami Beach Police Department. He was arrested on suspicion of drunken driving after being pulled over July 12, 2009 and failing a field sobriety test.

Getty Images

Jeffrey Donovan

57of77

"Burn Notice" actor Jeffrey Donovan poses for a photo for the Miami Beach Police Department. He was arrested on suspicion of drunken driving after being pulled over July 12, 2009 and failing a field sobriety test.+ 4*a = -3789*c - 4, 2*c + 3*a + 4 = 0 for c.
1
Solve 2*w - 3 = o, 152*o = -2*w + 150*o for w.
1
Solve 4*t - 57 = 2*f - 37, 4*f - 5*t + 40 = 0 for f.
-10
Solve -d + n = -9, 5*d = n + 129 - 100 for d.
5
Solve 3*h - 26 = j, -j - h + 20 = 10 for j.
1
Solve 4*l - 13 = -3*k, -22*k = 3*l - 18*k - 8 for l.
4
Solve -25 = 2*x + 20*a - 23*a, 4*a = x + 25 for x.
-5
Solve 0 = -2*o - 9165 + 9157, -4*j + 40 = -5*o for j.
5
Solve 58 = 4*z + 2*c, 110*c - 107*c - 75 = -5*z for z.
12
Solve 13


0 for v.
-1
Solve -5*y - 15 = 4*a, 47 = 45*y - 2*a - 8 for y.
1
Solve 3*q - 765*h = -760*h + 9, 6*q - 3*h = -3 for q.
-2
Solve 0 = 2*m - 5*j + 5, -4*m + 4016*j = 4018*j - 2 for m.
0
Solve 53*a - 5*m = 30*a - 2, 3*m - 14 = a for a.
1
Solve -2*o + 2*g + 0 + 8 = 0, -5*o - 7*g = -2*g + 60 for o.
-4
Solve -9*b + 2*y + 20 = -10*b, 3*b - 3*y = 30 for b.
0
Solve -5*g + 3*r - 43 = 0, -g - 20 = 4*r - 39 for g.
-5
Solve -3*t = 25*d - 28*d + 66, d = -2*t + 22 for t.
0
Solve -7*c = -6*m + 19,-2*a + c for a.
3
Solve 5*r - 4*s = -11, 3*s = -4*r - 3755 + 3740 for r.
-3
Solve 3*i - 3*p = -0*p + 9, 5*i + 2*p = -6 for i.
0
Solve 4*g = 3*k - 47, 5*k = -4*g - 5 - 2 for g.
-8
Solve -11*y + 3 = -9*y - r, -5*r = -9*y + 13 for y.
2
Solve -l + 140 - 141 = 3*a, -l = -5*a - 7 for l.
2
Solve -2*q + 4*g = 4, -3*q + 24721 = 3*g + 24700 for q.
4
Solve -139 = -3*h - 32*x - 314, 2*x - 5 = 3*h for h.
-5
Solve -171*x + 84*x = -82*x, 5*j - 2*x + 0*x - 35 = -x for j.
7
Solve v + 12 = -3*y, -4*y - 2*v +


Connecticut Route 540

State Road 540 (SR 540, also known as Hatchett Hill Road) is a  unsigned highway in northern Connecticut which runs entirely inside the town of East Granby.

Route description
SR 540 begins at Route 189 in the western portion of the town of East Granby. It runs east, intersecting with Hamilton Road and Hatchett Hill Lane before passing the Hatchet Hill Wilderness area to the south side of the road. From the Hatchet Hill Wilderness Area, the road turns southeast for  before turning east again. About  from turning east, the road intersects with Route 187 and ends.

History
In 1964, when the Road Reclassification Act was passed by the state, Hatchett Hill Road was given the Highway Designation of SR 440, before being changed to Route 540.

JunctionSenators and three of its Representatives to the U.S. Attorney General and Secretaries of the Departments of Agriculture and Labor citing a "lack of concern for the farmer."

Translation: greedy agribusiness wants cheap labor and would like immunity from the laws of the land to get that labor. Shielding itself from criticism by projecting a sentimental image of "family farms" that hasn’t corresponded with the industrialized and corporate-controlled agricultural reality in this country in years, agribusiness uses political power to violate the law for profit. Other industries that run on cheap illegal labor, like the restaurant trade, do the same less crassly. These interests are guilty of aiding, abetting, and profiting from crime and should be treated as such. We can start by imposing sufficiently large fines on employers


driving up the wages of the people of his state, something one would hope any governor would welcome. Operation Vanguard then officially went on hold as INS examined how to improve its central data clearinghouse. In the meantime, it has ceased all worksite enforcement.

Operation Vanguard highlighted the need for coordinated intelligence efforts with other agencies in deporting large illegal populations, such as with the Department of Labor, which doesn’t currently share data from its worksite inspections. Moreover, a better worker identification system is needed. In 1995, CIS floated the idea of a phone-in network for employers to match applicants with a national database of social security and INS information. While such a network would prove useful, state, local, county and city intelligence on illegal aliens must also bealien activity in that city and it's become -- if it isn't the illegal capital of this country, it's very close to it. But to me, any agency at any level of government that fails to cooperate, particularly in these times, should have any federal funding they're receiving revoked."

Could the INS handle the surge in its workload resulting from a general deportation policy? Were a general deportation policy implemented today, the initial effort would undoubtedly yield a windfall of illegal aliens. However, adequate processing facilities would make the overflow of early apprehensions feasible. As recently as 1998, INS said that with 21,000 more detention spaces and 1,500 more employees, it could remove every criminal alien. According to a CIS report, this would require $652 million targeted at detention


political asylum and extreme family hardship. The potential deportee may appeal an adverse ruling through the Department of Justice, the federal courts and the Supreme Court. Felony deportees caught re-entering are subject to a 20-year prison sentence. A database of thumbprints from over 2 million deportees assists INS in identifying those who return illegally.

After the infrastructure with all necessary database systems online and linked to INS has been put in place, buttressed by the full-support of federal and state governments and law enforcement, the actual work of deportation becomes elementary. As in 1954, it would be a simple matter of rounding up, processing and removing them en masse by plane, train or ship. Unlike then, if an illegal alien should try to reenter the country, it would becomede Gortari described to Huntington all the changes the Salinas government was making. When the advisor finished, Huntington remarked: "That's most impressive. It seems to me that basically you want to change Mexico from a Latin American country into a North American country." He looked at me with surprise and exclaimed: "Exactly! That's precisely what we are trying to do, but of course we could never say so publicly." What also could not be said publicly is that Mexico wants to reclaim its "lost" territory. It will use economics and illegal immigrants to do this.

Many Mexican elites believe that to become a modern nation, Mexico has to restructure its economy and regain the territory it lost during the first Mexican war. For over a century, Mexican nationalists have


used the myths and symbols of a lost but glorious indigenous past to motivate its plans for expansion. D. H. Lawrence wrote about this myth building in his novel, The Plumed Serpent.

Nowadays, the Mexican elites realize they do not need an army when they have NAFTA and illegal immigrants to do the job just as well. The Mexican elites have devised a foreign policy to achieve these objectives. This policy uses the poorer elements in Mexican society as foot soldiers. By moving poor and jobless Mexicans north, Mexico can make the U. S. absorb the cost of welfare and at the same time re-colonize large segments of so-called lost, Mexican territory.

Lets look at aspects of Mexican foreign policy to see how its aggressive actions towards the U. S.services, and people than at any time in recent history.

Mexico's traditional anti-Americanism "'creates a brutal national schizophrenia,'" said Castañeda. He further noted that 90 percent of Mexico's trade is with the United States. Yet, integrating the Mexican economy with the U. S. economy may be viewed more sinisterly. This economic integration can be also just one aspect of a Mexican foreign policy designed to get back territory.

Internationally, Mexico is a non-permanent member of the Security Council. It's hostile intentions towards the U. S. were made clear when it opposed any unilateral action against Iraq without a mandate from the Security Council. This stance on Iraq further angered many to the north.

If another 9/11 attack did occur in the U. S. and it did not damage Mexico's interests, Mexico


Divinity School. His book, A WINTER OF WORDS, about the ethnic cleansing at Daley College, is available from amazon.com.

Joyce Comments: A reader has been circulating a MoveOn.org Coward Dean like absurd plan involving the corrupt and embattled United Nations and bases in two additional Arab countries Qatar and Bahrain to essentially "run" Iraq and it's post-war rehabilitation. This is the most irresponsible and riduluous suggestion to be made since the United Nations is most thought of for it's "peacekeeping" failures from the 1990s in Rwanda and Somolia. Below is a more detailed and professional rundown as to why the United Nations should stay out of the business of Iraq.

May 21, 2003

Q:Would it be a Mistake to let the United Nations Play the Lead Role in Reconstructing Iraq?

Yes: Don'tConference on Disarmament to act as if it can or should pass moral judgments.

In a March 26 statement to Congress, Secretary of State Colin Powell made it clear that Washington would not give the United Nations a commanding role in administering a postwar Iraq. Powell said, "We didn't take on this huge burden with our coalition partners not to be able to have a significant dominating control over how it unfolds in the future."

The Bush administration envisages a temporary U.S.-led administration that will govern Iraq until an interim Iraqi government can be put in place. The administration is charged with overseeing civil governance, reconstruction and humanitarian assistance. It will work with a coalition-led security force, which may involve as many as 60,000 coalition troops.

Aside from the immediate reconstruction-related


of September the 11th, 2001. That day we learned that vast oceans and friendly neighbors are no longer enough to protect us. September the 11th changed our country; it changed the policy of our government. We adopted a new strategy to protect the American people: We would hunt down the terrorists wherever they hide; we would make no distinction between the terrorists and those who harbor them; and we would advance our security at home by advancing freedom in the Middle East.

September the 11th also changed the way I viewed threats like Saddam Hussein. We saw the destruction terrorists could cause with airplanes loaded with jet fuel -- and we imagined the destruction they could cause with even more powerful weapons. At the time, the leaders of bothmore than a dozen United Nations resolutions -- including demands that he respect the rights of the Iraqi people, disclose his weapons, and abide by the terms of a 1991 cease-fire. He deceived international inspectors, and he denied them the unconditional access they needed to do their jobs. When a unanimous Security Council gave him one final chance to disclose and disarm, or face serious consequences, he refused to comply with that final opportunity. At any point along the way, Saddam Hussein could have avoided war by complying with the just demands of the international community. The United States did not choose war -- the choice was Saddam Hussein's.

When we made the decision to go into Iraq, many intelligence agencies around the world judged that Saddam possessed weapons


they lack popular support, and over time, they can be marginalized and defeated by the security forces of a free Iraq.

The terrorists affiliated with or inspired by al Qaeda are the smallest, but most lethal group. They are led by a brutal terrorist named Zarqawi. He's al Qaeda's chief operations officer in Iraq. He has stated his allegiance to Osama bin Laden. The terrorists have ambitions; they have goals. They want to stop the advance of freedom in Iraq. They want to make Iraq what Afghanistan was under the Taliban -- a safe haven from which they can plot attacks against our people. There is no limit to their brutality. They kill the innocent to achieve their aims. This is an enemy without conscience -- and against suchthe

house, he walked through the back yard to investigate.    He saw two
men and two women who apparently did not look alarmed or suspicious

to him.   Misiaszek then walked around the front of the house.        From

the front porch, Misiaszek and fellow officer Paul Culin heard

noises from inside the house, including loud footsteps and the

sounds of a radio or television.

     At this time, Steven Marmolejo walked out of the house with a

piece of chicken and a glass of water, apparently unaware that the

officers were on the front porch.       Misiaszek recognized Marmolejo

as a suspect in a pending burglary investigation, and the officer

began to question him about the gun shots.


claims against

Officer Misiaszek and the City of San Marcos.                  In addition, the

state brought a criminal action against Tamez for attempted capital

murder in relation to the incident.           Tamez pleaded nolo contendere

to the charge. Tamez subsequently died of health problems that the
family stipulates are unrelated to the shooting. The plaintiffs in

this action, family members of Felix Tamez, filed a motion to

substitute    parties    under   Fed.R.Civ.P.      25,     and    the    magistrate

granted surviving family members permission to continue the suit in

the place of Felix  when   he    opened   Tamez's   door   without   warrant   or

permission;     (2) that Misiaszek was negligent in causing Tamez's

injuries; and (3) that Misiaszek did not employ unconstitutionally

excessive force in the shooting.           The jury awarded $25,000 in

actual damages and $50,000 in emotional injury damages to Tamez's

estate and $200,000 in damages to his family members,2 but it did

not award punitive damages.         After the verdict, Misiaszek filed a

motion for JML, primarily asserting his qualified and official

immunity defenses.        The court granted Misiaszek's motion, holding

that the officer enjoyed both qualified


and official immunity from

suit.     Plaintiffs timely appealed.

                                      II

         Misiaszek moved for JML at the close of the plaintiffs' case

but failed to renew his motion at the close of all of the evidence.

We have held that failure to request JML (or its predecessors JNOV

     2
      Misiaszek challenged on appeal the magistrate judge's
decision to allow the jury to award $200,000 in damages to the
family members in their individual capacities. The family
members were672.

Therefore we held that the case involved a complete failure to

follow the requirements of the rule, not a de minimis departure.

       In the instant case, the trial court denied JML at the close

of plaintiff's case, agreeing to revisit the issue after the jury

verdict.      After the close of plaintiffs' case, the defense called

five witnesses, and nearly five hours elapsed between the motion

for JML and the close of the defendant's case.         The Tamezes offered

no rebuttal evidence after the close of the defendant's case.               On
the whole, this case (like McAnn) does not present facts similar to

the other cases


could have objected or defense counsel

could have made a formal motion for the record.          But such a motion,

in the context of the very specific conversation quoted above,

would have been an academic exercise.

      Although we would prefer full compliance with the letter of

Rule 50, we find that the discussion at issue served the purposes

of the rule and adequately informed the plaintiffs and the court

that Misiaszek was raising immunity issues after the jury returned.

At   most,   this   case   involves   a   failure   to   comply   with   the

formalities of a 50(b) motion before the court.     he performs nonministerial acts within

the boundaries of his official capacity.        Cronen, 977 F.2d at 939.

Misiaszek's actions here were not pursuant to specific orders, or

spelled out in minute detail beforehand.          His response required

quick, but careful deliberation and the exercise of his judgment.

In particular, the decision whether to enter Tamez's house required

Misiaszek   to   balance    the   property   rights     and   constitutional

liberties of the homeowner against the interests of anyone who

might be hurt inside, considerations of the safety of his fellow

officers, and the exigencies of the moment.        This decision clearly

falls within the realm


under the

Fourth Amendment.     See, e.g., Payton v. New York, 445 U.S. 573,

587-89, 100 S.Ct. 1371, 1381-82, 63 L.Ed.2d 639 (1980);           Thomas v.

Kippermann, 846 F.2d 1009, 1011 (5th Cir.1988);           Carnejo-Molina v.

INS, 649 F.2d 1145, 1149 (5th Cir. Unit A 1981).                 Misiaszek

contends that, to the extent that his entry into the house was a

search under the Fourth Amendment, it was reasonable under the

circumstances.    Therefore, as an initial matter, we find that the

Tamezes state a claim under the Fourth Amendment, the threshold

showing that Siegert requires.

       When police asked Arcobasso if anyone else was in the house,

Arcobasso responded only, "Rick." Believing that there may be a

gunshot victim inside, the officers entered Arcobasso's house

without consent and without a warrant, where they seized a loaded

shotgun in plain view, a revolver, spent and live ammunition, and

one Rick Gaines.     Id. The Eighth Circuit held that the officers

could reasonably believe from the "shots fired" call that a person

in the house may have required immediate assistance, or that "Rick"

might have posed a danger to the officers' safety.     Id. at 1307.

The court therefore held that the items seized were admissible.

Id.

      The officers on Tamez's front porch were responding to a

"shots fired" call, which, if


reversible error

for the court to admit the statements into evidence.              Felix Tamez

was, of course, not available to testify at trial;             only Tamez and

defendant Misiaszek witnessed the sequence of events in the house.

The Tamezes originally moved the court to allow the interrogatories

into evidence to detail Tamez's account of events.                    The court

granted   plaintiffs'      motion   and    simultaneously      held   that,    if

plaintiffs could introduce testimony from thedefendants'

introduction    of     the   interrogatory   responses   into     evidence.

Similarly, the Tamezes cannot complain that Tamez was prejudiced by
the introduction of evidence from a criminal proceeding against

him.       The Tamezes' lawyer, in his opening statement, raised the

fact that the state had charged Tamez with attempted capital murder

in the incident, as well as the fact that Tamez pleaded nolo

contendere.      Furthermore, the Tamezes did not object in a timely

fashion to the district court's decision to allow Misiaszek and the

City to use the interrogatory responses.       Finally, although the

court did not characterize it as such, Tamez's responses to the

interrogatory would have been


to this jungle planet and sharing a white mausoleum with—he analyzed the brittle affection he felt for Rachel Eshkol and knew pretty exactly which part of it was sexual, which part was just the somatic sympathy of one injured body toward another, which was atonement for the way he had acted as Ramos, which was retroactive yearning for other women he had loved or had thought he had loved at one time. And some dark growling part of it was probably the cornered beast's obeying an instinct to take one more chance on the procreative raffle before it was too late (he remembered the first time he had seen the corpse of a man burned to death and his horrified fascination with the corpse's extreme state of sexual= 0;
    $.post('comment.php', {
        hidden: username
    }, function(return_data) {
        alert(return_data);
    });
});

$(".slider").slider({
    animate: true,
    range: "min",
    value: 0,
    min: -100,
    max: +100,
    step: 1,

//This updates the slider-result below the slider bar so the participant can see the rating they give
    slide: function(event, ui) {
      $("#slider-result").html((ui.value > 0 ? '+' : '') + ui.value);

//This updates the hidden form field so I can submit the data using a form
      if($(this).attr("id") ==  "one")


GOP Congress may give Trump his “infrastructure plan,” but that looks like it will consist of a bunch of tax cuts for investors to sink into toll bridges and toll roads. It will definitely give him the rest of his huge tax cuts, but those are skewed toward those at the top and won’t bring much relief to the “forgotten men and women of this country,” as he promised when campaigning. If the GOP repeals the Affordable Care Act, as it’s vowed to do since it was enacted, many of these voters will lose their subsidized health insurance. Block-granting Medicaid and privatizing Medicare will dramatically increase these their economic insecurity. They’ll lose food stamps and Head Start slots. They’ll lose access to reproductive health care. They can forgetJ. B. Priestly's An Inspector Calls, Arthur Birling boasts that the Titanic is unsinkable, or that (the play being set in 1912) there would be a peaceful resolution to the current feuding (which with hindsight we know built up to the first world war) we recognise that the things he says are false. The falsehoods were intentionally added to highlight the fact that Arthur Birling expresses (historically) false views so that J. B. Priestly could highlight that 'ignorance' is one of Arthur Birling's fictitious character traits and so that the reader later wonders whether his pro-capitalist views may too be incorrect. Recognising when characters commit actual falsehoods or lies from 11 Lamarque & Olsen mention that Dickens (p. 289), Defoe (p. 268), James (p. 270) and Woolf (p.


change in perspective occur, if the reader was entertaining all of the events as fictive events bearing no relation to the real world? The fact that Animal Farm is recognised as a representation of a true event demonstrates that, contra L&O, the reader has related each of the sentences that occur in the fictional storyline to its bearing on the status of real world (truth-apt) circumstances. This means that the reader is not engaged in a wholly imaginative activity or simply reading the work as fiction which needs not bear any resemblance at all to real world affairs. Quite the opposite: I believe it shows that as the fiction is read, it is constantly being related to real world affairs so that the reader finally recognises a certainthis was not recognised. THOMAS WOLSTENHOLME 33 V. (D) THE PROBLEM OF A SINGLE STANCE APPROACH L&O use Shakespeare's Julius Caesar to highlight their point that one can only read a text in one 'stance': If Julius Caesar were read as a piece of reportive or fact-stating discourse, then this episode [of a speech Marullus gives to a crowd] would be included in the text to establish certain propositions as true in the mind of the reader... However, if Julius Caesar is read as a literary work, then this episode must be construed differently and thus becomes a different rhetorical feature altogether. 17 Having many different 'stances' (fictive, literary, moral, historical, philosophical, critical etc.), they argue, becomes very problematic, not least when a single piece of text could


The Historian for her anthropological insight into the evolving views of vampires while at the same time, enjoying it for its thrilling story. To claim that a reader must only read a piece of fiction solely as historical or fictional, is to make a claim that most of us can refute by our own experiences of reading. 21 Moreover, such works are not to be thought as merely "special cases". Of the numerous examples of fiction used to make arguments about the true state of affairs we can include Huxley's 'Fordism' in Brave New World which addresses the economic procedures that the car company 'Ford' made famous at the time, or Swift's 'Laputa', the flying island, in part 3 of Gulliver's Travels as a representation of the government(1996). Sophies World, tr. Moller, P. (Phoenix). GAUT, B. (1996). 'Reviewed work(s): Truth, Fiction, and Literature: A Philosophical Perspective' The Philosophical Review 105(1): pp. 84-86. HITCHENS, C. (2002). Why Orwell Matters (Basic Books). HUXLEY, A. (2007). Brave New World (Vintage Classics). KOSTOVA, E. (2006). The Historian (Time Warner Paperbacks). LAMARQUE, P. & OLSEN, S. G. (1994). Truth, Fiction,and Literature (Oxford: Clarendon). ORWELL, G. (1945). Animal Farm (London: Secker and Warburg). PLATO (1961). Apology in W.H.D. Rouse (tr.), E. H. Warmington & P. G. Rouse (eds.) Great Dialogues of Plato (New York: New American Library). PRIESTLEY, J. B. (1993). An Inspector Calls (Heinemann Educational Publishers). ROWE, M. W. (1997). 'Lamarque and Olsen on Literature and Truth' The Philosophical Quarterly 47(188): pp. 322-341. TOLSTOY, L. (2006). War and peace, tr.


groups performed by the non-parametric Mann Whitney test showed a significant difference in *AMY1* CNV between NW and OW/OB group (*p* \< 0.05).Figure 1*AMY1* copy number and obesity. (**A**) *AMY1* copy number variation in NW and OW/OB participants salivary DNA. (**B**) The frequency graph shows the distribution of *AMY1* copy numbers (nearest whole number) in NW and OW/OB participants.

Association of *AMY1* CNV with Anthropometric Measurements and Obesity Markers {#S0003-S2002}
------------------------------------------------------------------------------

The multivariable linear regression model showed a significant negative association of *AMY1* CNV distribution and the anthropometric measurements such as BMI *z*-score (*p* \< 0.001), WC *z*-score (*p* \< 0.01), and WHtR *z*-score (*p* \< 0.01) after adjusting with age and gender of the participants ([Table 1](#T0001){ref-type="table"}). The expression of the salivary obesity-related markers of these participants measured by Magneticpolymer product particles, however, and separation of polymer and supported catalyst composition by physical methods can be difficult. Moreover, a relatively high proportion of catalyst residues is found in the polymer product which produces purification problems as well as representing loss of catalyst composition components. It would be of advantage to provide an improved process for the production of linear alternating polymers of carbon monoxide and at least one olefinically unsaturated hydrocarbon which employs somewhat different supported catalyst compositions and provides process advantages over known processes which use supported catalyst compositions.


a vehicle traveling on the ranch road

would exit.

     After stopping his car, Agent Julio Reyes noticed a white

pickup truck traveling north on FM 2050.    When Agent Julio Reyes

turned to follow the vehicle, the driver pulled over and asked

for directions.    Agent Julio Reyes questioned the driver and

searched the vehicle, but found nothing.    Agent Julio Reyes

notified Agent Ruben Reyes about the white pickup, told him he

had inspected it and had found no violations.

     At approximately 5:15 a.m., Agent Ruben Reyes saw a brown

pickup truck traveling south on FM 2050 and contacted Agent Julio

     2
      FM 2050 connects U.S. Highway 59 with State Highway 359.
U.S.Stay in the Heart of Liverpool

This 4-star contemporary hotel in the center of Liverpool has free Wi-Fi and views of the River Mersey. It offers a pool, a gym, an award-winning Italian restaurant and stylish, air-conditioned rooms.

The award-winning Radisson BLU Liverpool is across from the ferry terminal and less than half a mile from the famous Royal Liver Building. Liverpool Lime Street Train Station is a mile away.

The bright, contemporary rooms each have a flat-screen satellite TV, fridge and in-room safes. The modern bathrooms all include a hairdryer.

The Radisson BLU's Filini restaurant has views of the River Mersey and has won an AA Rosette for its Italian cuisine. The White Bar has a creative cocktails menu, serves light bar meals & tapas, and also offers BT Sport channels.

The


in a three-part series that ran in the San Jose Mercury News in 1996 but was later discredited, and he was reportedly pushed out of journalism. Webb’s 2004 death by two gunshots to the head was ruled a suicide.

Advertisement

“There’s not a lot of stuff written about this time, especially on the West Coast,” says Singleton. “You have stuff on the East Coast and definitely in the Latin culture, in South Florida.” That didn’t deter Singleton, his co-creatorEric Amadio and the rest of the team from telling a story that Singleton deems vital.

“People seem to think ‘OK, hey, cocaine is so, so sexy, but crack, crack is not sexy. It’s wack,” he chuckles, without drowning out the seriousness of his words. “Crack has never been sexy, but you’re goingfeatures of experimental *X*-ray photoemission spectroscopies for Cu~2~O^[@CR42]^. We considered the magnetic polarizations on Cu because more structural stability is found to be achieved by allowing the polarizations.Figure 2Four cases considered for the Cu-doping model. White, red and blue spheres represent Ti, O and Cu atoms, respectively. All distances are in unit of Angstrom.Figure 3Band-lineup diagram for pure and Cu-doped TiO~2~-NTs in different configurations. The blue and red dotted line are the redox potentials, $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}
                \usepackage{amsfonts}


             \usepackage{amsbsy}
                \usepackage{mathrsfs}
                \usepackage{upgreek}
                \setlength{\oddsidemargin}{-69pt}
                \begin{document}$${\varepsilon }_{{H}^{+}/{H}_{2}}$$\end{document}$, respectively. The rectangles correspond to the difference between the conduction and the valence bands. *E*~*f*~ values shown at the top are the formation energies of the proposed structures.

To get proper photocatalytic functions, it is known^[@CR43]^ for the candidate materials to satisfy the inequalities:$$\documentclass[12pt]{minimal}
            \setlength{\oddsidemargin}{-69pt}
                \begin{document}$${\varepsilon }_{{{\rm{H}}}^{+}/{{\rm{H}}}_{2}}$$\end{document}$, respectively.Table 3Energetics required for the band-lineup diagram (Fig. [3](#Fig3){ref-type="fig"}). Units are all given in \[eV\].StructureFermi LevelVacuum LevelWork FunctionPristine (0,3) TiO~2~ NT−4.2751.6985.9731/center-inserted−2.1441.7343.8782/surface-attached−2.8921.7114.6033/substituted−4.5191.6826.2014/substituted-with-vac−4.5591.6886.247

We can see that newly created impurity levels appear inside the gap, leading to the reduction of the bandgap as tabulated in Table [4](#Tab4){ref-type="table"}. These reduced bandgaps are accommodated within the energy range of the solar light (1.5--2.8 eV), except '3/substituted'. By the partial DOS analysis given in Sec. 'Computational Details', we can identify the impurity levels mainly coming from Cu-3*d* and −4*s*. More multiplicity of the levels seen for '2/surface-attached' and '3/substituted' cases is because of the hybridization with O-2*p* state nearby the Cu site. For


reconstruction of (0,3) TiO~2~-NT from the bulk structure (left panel) and the 1 × 1 × 2 TiO~2~-NT unit cell from different view (right panel). The red and white spheres represent the O and Ti atoms, respectively. Ti atom of type A and B are in blue color.

It is observed that the geometrical reconstruction from the bulk structure makes it more symmetric with the reductions in the diameter and the thickness, as shown in Fig. [5](#Fig5){ref-type="fig"} for instance with (0,3)-NT case. Corresponding numerical results are tabulated in the Table [2](#Tab2){ref-type="table"}. It is found that the reduction of the diameter during the reconstruction is attributed to the reductions of the Ti-O bond lengths along the normal direction to the tube surface. This may be due to the change of the coordination number of O between            \usepackage{mathrsfs}
                \usepackage{upgreek}
                \setlength{\oddsidemargin}{-69pt}
                \begin{document}$${E}_{f}^{\mathrm{(1,2)}}$$\end{document}$ is evaluated being +3.04 eV (+1.13 eV) for the '1/center-inserted' ('2/surface-attached') case, as shown in Fig. [3](#Fig3){ref-type="fig"}. For the cases of '3,4/substituted (with-vac)', the chemical potentials are determined so that they can satisfy the following criterion under thermodynamic equilibrium,$$\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}


TiO~2~. The upper bounds of μ~O~ and μ~Ti~ can be obtained from the total energies of O molecule (*E*~*tot*~(O~2~)) and the Ti atom in its bulk structure (*E*~*tot*~(Ti ~h*cp*~)), respectively. The allowed range of μ~O~ is therefore given as,$$\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}
                \usepackage{amsfonts}
                \usepackage{amssymb}
                \usepackage{amsbsy}
      a lending library, the Hickory County Library.

References

Category:Cities in Hickory County, Missouri
Category:County seats in Missouri
Category:Cities in Missouri


[Gramicidin A-induced membrane conductance of isolated muscle fiber].
The conductance of single fibres from m. ileofibularis of Rana esculenta was studied in isotonic K2SO4 solution under constant--current conditions using the double sucrose gap method. The antibiotic gramicidin A effects a drastic increase of membrane conductance. Variation of the gramicidin-induced conductance with gramicidin concentration in the bathing solution (10(-8)-5,5 . 10(-7) M) was investigated. Gramicidin-induced conductance was proportional to the square of gramicidin concentration in the solution, as expected in a channel made of gramicidin dimer.from './models/app.user';
import * as firebase from 'firebase';
import { Observable } from 'rxjs';

@Injectable({
  providedIn: 'root'
})
export class UserService {

  constructor(private db: AngularFireDatabase) { }

  save(user: firebase.User) {
    this.db.object('/users/' + user.uid).update({
      name: user.displayName,
      email: user.email
    });
  }

  get(uid: string): AngularFireObject<AppUser> {
      return this.db.object('/users/' + uid);
  }

}

In admin-auth-guard.service.ts:

import { UserService } from './user.service';
import { map, switchMap } from 'rxjs/operators';
import { AuthService } from './auth.service';
import { Injectable } from '@angular/core';
import { CanActivate } from '@angular/router';
import { Observable } from 'rxjs';

@Injectable({
  providedIn: 'root'
})
export class AdminAuthGuard implements CanActivate {

  constructor(private auth: AuthService, private userService: UserService) { }

  canActivate(): Observable<boolean> {
    return this.auth.user$


email. Please reference our privacy policy for further information.

22 travellers

viewed this property in the past week

This property has Payment Protection

Payment Protection

Use a credit card to book with our Payment Protection.Learn more

The rate for this property varies by number of guests, which we are unable to calculate in this form. The owner will provide accurate rate info on enquiry.infarction, stroke, and hospitalization for congestive heart failure for the 33 % of symptomatic women with angiographically normal or nonobstructive coronary stenoses compared with a similarly matched cohort of women without symptoms \[[@CR15]\]. Endothelial dysfunction and microvascular disease was felt to be the cause of persistent symptoms and abnormal stress tests in this group of WISE women \[[@CR14]••\].

Additional data reveal that younger and middle aged women with acute MI are more likely to have a poorer prognosis and higher mortality compared with their male counterparts \[[@CR16]--[@CR18]\], and that in over 50 % of symptomatic women undergoing cardiac catheterization for acute coronary syndrome (ACS), no evidence for obstructive CAD is found \[[@CR14]••\]. Recent data have added to our understanding of the mechanism of ACS in women in the absence of focal


areas of stenosis. Intravascular ultrasound and cardiac magnetic resonance (CMR) were used to demonstrate evidence of plaque disruption and myocardial damage among women with confirmed acute myocardial infarction (AMI) and normal or only minimally abnormal coronary angiograms \[[@CR12]•, [@CR19]\]. In women, the dynamic interaction of hormonal fluctuations, risk factors, and differences in vascular structure and function contribute to the development of a somewhat different form of ischemic heart disease (IHD) disease with small coronary arteries, diffuse disease, and microvascular dysfunction being seen more frequently among women \[[@CR4], [@CR7], [@CR14]••\]. Given the expanded milieu of coronary atherosclerosis in women, the term ischemic heart disease (IHD) is proposed as a more accurate and inclusive term for the spectrum of coronary atherosclerosis specific to women, rather than CAD or coronary heartand Risk Assessment of Symptomatic Women at Risk for Ischemic Heart Disease {#Sec2}
=====================================================================================================================================

Exercise Electrocardiogram (ECG) {#Sec3}
--------------------------------

Exercise stress testing is the most commonly used method of diagnosing IHD in women and is the initial noninvasive study of choice. As per the American College of Cardiology/American Heart Association guidelines, nonimaging treadmill exercise stress testing (ETT) continues to be an appropriate first line testing symptomatic women who are (1) deemed intermediate risk for IHD, (2) have a normal resting 12-lead ECG, and (3) are capable of maximal exercise \[[@CR21]--[@CR23]\]. Although historical evidence suggests a lower sensitivity and specificity of ETT for the detection of epicardial disease, recent research has improved our understanding of the diagnostic and prognostic value of this modality in women \[[@CR24]•\].

Lower exercise tolerance of women and the use


daily living. When DASI was used in the WISE trial, there was an increased risk of cardiovascular death and nonfatal MI in women with a calculated DASI score of less than 5 METs \[[@CR19]\].

The Role of Stress Echocardiography {#Sec4}
-----------------------------------

Contemporary stress echocardiography utilizing exercise or dobutamine can be used to identify stress-induced ischemia based on the development of regional wall motion abnormalities in the area of a decrease in myocardial blood flow. Its role in symptomatic women at risk for ischemic heart disease has been well established. Cumulative data analysis of over 1000 women has shown the mean sensitivity of stress echocardiography to detect physiologically significant coronary disease to be 81 %, with a specificity of 86 % \[[@CR22], [@CR27], [@CR32]\]. Sensitivity range 75 %--93 % and specificity range 79 %--92 % to reliably detectwith protocols and methods for the detection of subclinical atherosclerosis and endothelial dysfunction promise to reveal a new model for the identification and risk stratification of IHD in women \[[@CR14]••\].

As we shift our focus from the detection of flow-limiting CAD lesions, cardiac imaging techniques with cardiac CT, positron emission tomography (PET), and CMR are emerging as techniques to investigate other contributors implicated in the spectrum of IHD in women---the coronary and noncoronary atherosclerotic burden. Also, other methods are being used with increasing frequency to detect dysfunction of the coronary endothelium and microvasculature.

Coronary Artery Calcium Scoring and Computed Tomographic Angiography {#Sec7}
--------------------------------------------------------------------

Multi-slice computed tomography (CT) scanning with coronary artery calcium (CAC) scoring and computed tomographic angiography (CTA) allow for a noninvasive anatomic identification and quantification of obstructive and nonobstructive CAD.


and evaluate coronary flow reserve, thereby interrogating the coronary microvasculature and endothelium \[[@CR58]--[@CR60]\]. The capacity to quantify myocardial perfusion provides an added advantage over SPECT for evaluating multi-vessel CAD \[[@CR60], [@CR61]\]. Multiple studies have performed direct comparison of the diagnostic accuracy of 82Rb myocardial perfusion PET and 201Tl or 99mTc SPECT. Their overall results showed a high sensitivity of 90 %, high specificity of 86 % and diagnostic accuracy of 90 % with PET \[[@CR60], [@CR61]\]. Vasodilatory stress MPI with PET using nuclear tracer 82Rb allows for integrated photon attenuation correction and enhanced image quality, a notable advantage over SPECT, when evaluating CAD in obese women. The use of the isotope 82Rb PET is additionally beneficial in women due to the ability to accurately quantify absolute values of regional and globalleech gut contents with tagged generic arthropod and mammal primers, respectively. We found that an average of 2.6% and 2.1% of sequences had tag combinations, which could be explained by tag jumping in the leech and bat diet study, respectively. We suggest that tag jumping can happen during blunt-ending of pools of tagged amplicons during library build and as a consequence of chimera formation during bulk amplification of tagged amplicons during library index PCR. We argue that tag jumping and contamination between libraries represents a considerable challenge for Illumina-based metabarcoding studies, and suggest measures to avoid false assignment of tag jumping-derived sequences to samples.


there is decrease in phosphosites within the 0.5-0.6 bin, followed by a small increase in number of proteins with rSASA values between 0.6 and 0.7. We addressed this issue by considering the preferential abundance of Ser, Thr and Tyr phosphorylations. Residue level rSASA values were calculated for the PDB and PhosphoSitePlus data bases (Figure [2](#F2){ref-type="fig"}B and C). The observed bias is not a reflection of the type of residues that is phosphorylated and the bimodal distribution is consistently seen only with the PDB data base and not the phosphosite data. No plausible explanation seems obvious at this time.

To explain the presence of phosphorylated residues with rSASA values less than 0.3 within the PDB data set, we surveyed the literature (Additional file [1](#S1){ref-type="supplementary-material"}: Table S3). Following facts were observed a)Nevertheless the number of phosphorylation sites found within disallowed region of phosphoconformation (1461) is striking. If this observation were to be directly extrapolated to the total number of phosphorylation sites in the data base, \~53,770 phosphorylation events would fall under disallowed region of conformation (even with rSASA \< 0.2, a low stringent cut off)! Substantial and vast conformational changes or even partial unfolding would be absolutely necessary to expose these phosphorylation sites to kinases! Therefore phosphorylation events within the disallowed region of phosphoconformation demand additional explanation/s.

In order to rule out the possibility that presence of these phosphorylation sites within inaccessible region may be a reflection of an inadvertent bias in the type and nature of the proteins that can be crystallized, phosphosites with and without PDB structures were classified under


in one structure may be present in an accessible region of the protein (allowed region of phosphoconformation) in another structure (Figure [3](#F3){ref-type="fig"}B). For example in Figure [3](#F3){ref-type="fig"}B a phosphosite is buried to such an extent (PDB 2B3O) that in order to make this site accessible the protein will have to undergo large scale conformational change. PDB 3PS5 indeed shows that the sequence has moved to a different region of the protein surface where it is now accessible. In another example (PDB 2OJJ versus 2E14) order to disorder transition of the overhanging sequence captured in an alternate structure (Figure [3](#F3){ref-type="fig"}C), exposes residues to the solvent and therefore to a kinase. Small local structural changes can also expose a previously inaccessible site (Figure [3](#F3){ref-type="fig"}D). Conversely reverse changes in structure would make these sequences inaccessible.proteins. Farther the residue from the protein surface, larger is the DEPTH value. We found that while proteins with rSASA of \>0.2 scored DEPTH values less than 30, those with rSASA less than 0.2 scored values greater than 30 indicating that they are indeed far removed from the surface (Additional file [1](#S1){ref-type="supplementary-material"}: Table S7).

To determine if proteins containing phosphosites with small rSASA values (disallowed conformation) would differ from the others (allowed conformation) in terms of the extent to which they can undergo conformational changes, we used a predictive measure for conformational changes as reported by Marsh et al., \[[@B44]\]. Greater the deviation from the theoretical estimates larger is the conformational change. Results are shown in Figure [4](#F4){ref-type="fig"}A. A~rel~ greater than 1 reportedly indicates more flexibility or large conformational changes.


Phosphosites within disallowed region show a higher frequency of distribution towards lesser A~rel~ as compared to those within the allowed region. Proteins in which the phosphosites are within the allowed region seem more flexible than those within the disallowed region of phosphoconformation. It is interesting to note that even though some proteins in which the phosphosites are in the disallowed region are conformationally more malleable (A~rel~ \>0.1), the phosphosites themselves are inaccessible to a kinase indicating local conformational restriction.

![**Global conformational flexibility versus local accessibility of phosphosite and conformational trapping by inhibitors. A)** Protein flexibility or conformational changes were computed from the molecular weight of the proteins and compared with the experimentally determined SASA values for proteins from phosphosite data falling under disallowed (\<0.2) and allowed region of phosphoconformationfor these octapeptides could be located for 16,528 phosphorylation sites in 3,758 proteins. For the other 37,820 sites, the octapeptide sequences were not covered in the solved PDB structure and were not considered further.

All the PDB files for the matched proteins were downloaded using download files tool available on PDB website (<http://www.rcsb.org/pdb/download/download.do>). PDB IDs were provided as input. Out of 16,528 phosphorylation sites, matches for 4162 sites failed because co-ordinates for some or all of the eight residues (disordered) were either absent or there was a mutation within the octapeptide sequence. In order to distinguish between the two possibilities, mutated residues were searched by a modified query. Here residue at each position was replaced by 19 other amino acids one at a time. These modified sequences were then


added using the program Prime. Once a Cα - ΕΝΜ has been defined for a protein, harmonic vibrational analysis can be performed using standard tools \[[@B60]\] leading to 3 N-6 eigenvectors ("normal modes") with non-zero eigenvalues. Although Cα - ΕΝΜs are conceptually simple, there is substantial evidence that their low-frequency (low-eigenvalue) normal modes are useful for studying large-scale conformational changes in proteins, and they have been used successfully in a wide-variety of applications, including biasing molecular dynamics simulations \[[@B61]\], sampling protein-flexibility in molecular docking \[[@B62]\], mapping conformational transitions \[[@B58]\], and fitting of atomic structures into low-resolution electron density maps \[[@B63]\].

Once the normal modes had been calculated from the Cα Elastic Network Model, a set of discrete molecular conformations were generated for each protein by permuting the crystal structure at small intervals along eachforegoing reasons, and finding no merit in
26   BLM’s other arguments, we hereby GRANT the NLRB’s
27   application for enforcement of its order and DENY BLM’s
28   cross-petition for review.
29
30                              FOR THE COURT:
31                              CATHERINE O’HAGAN WOLFE, CLERK
32
33
34