Tricorn protease exists as an icosahedral supermolecule in vivo.
Tricorn protease is the core enzyme of a recently discovered modular proteolytic system. We present evidence that tricorn protease exists in vivo in the form of a higher-order assembly, namely as an icosahedral capsid. Its size exceeds that of many virus particles and represents by far the largest known homooligomeric enzyme complex. Each capsid is built from 20 copies of the tricorn hexameric toroid and thus has a molecular weight of 14.6 MDa. Three-dimensional reconstructions of ice-embedded capsids from electron micrographs show that it is hollow and has large void volumes in its wall. We suggest that the tricorn capsid, in addition to its intrinsic proteolytic activity, serves as the organizing center of a multienzyme complex.Kevin Hart

Kevin Hart has a point. I looked at my Facebook feed about four months ago, and I couldn’t believe the amount of negativity. Most of what I was just seeing was just half-truthed meme’s that are just too easy to share. People are lazy. They don’t want to express themselves when they can only find a meme from someone else and say, “So true.” or “This is spot on.” I understand if you see a meme that you particularly like or that you find funny and you share it. That makes sense. But I have friends where it’s 95% of their content. Democrats do this, Libtards do that, Conjobs are that Trump, etc. all way to easy. Have you ever looked at the comments on those posts?


shear force component to compression force component are low, ranging between 0.09 (SD 0.04) and 0.14 (SD 0.09), while the inferior glenohumeral ratios range from 0.08 (SD 0.02) to 0.13 (SD 0.03). Consequently, the findings of this study provide scientific support for current rehabilitation guidelines regarding feeding tasks; this scientific evidence gives credence to clinical advice given, with the potential to reduce patients\' fear and anxiety relating to re-injury and thereby improving confidence in performing activities of daily living.

In contrast to feeding tasks, the glenohumeral ratios for functional activities of daily life such as perineal care, cleaning back and reaching opposite axilla range between 0.16 (SD 0.07) and 0.25 (SD 0.11) and between 0.17 (SD 0.09) and 0.58 (SD 0.36) for anterior and superior ratios, respectively. These datathis study {#s0060}
------------------------------

This study has several modelling limitations. First of all, the scapula kinematics for the ADL1 dataset was derived from regression equations rather than measured kinematics. However, given the moderate joint angles for a large number of those activities, the effect should be relatively small ([@bb0160]). Secondly, the validation of musculoskeletal shoulder models has demonstrated small differences between model output and instrumented shoulder implant measurements. The model improvement could include patient-specific scaling of the model and optimisation of the muscle load-sharing cost function. Thirdly, not all functional activities of daily living were performed by the same participants. Fourthly, the glenohumeral compressive force component is directed towards the mid-glenoid as the UKNSM does not account for humeral head translation. As the humeral head exhibits a small degree of


in-vivo translation during functional daily activities ([@bb0155]), the loading is not applied through the centre of the glenoid, which produces a torque around the glenoid-labral socket. As the articulating surface of the glenoid is rather shallow and translational movements are small ([@bb0095]), this effect is expected to be small. Finally, the presented shoulder loads can only be partly transferred between different age groups due to kinematic changes ([@bb0150]), and the presented data are only valid in the glenoid coordinate system and will have to be transformed into the humeral frame when assessing humeral loading during functional activities of daily living.

5. Conclusion {#s0065}
=============

This study analyses shoulder compression force components and shear force components during 26 functional activities of daily life utilizing a musculoskeletal shoulder model. The results demonstrate substantialthe influence of an extreme
emotional disturbance when he killed Jacqueline Anderson, then he
would be culpable for manslaughter, not murder."  And, therefore,
defendant argues, the "jury would have acquitted defendant of
both counts [of aggravated murder]."  In defendant's view, the
trial court's actions "deprived [him] of this plausible route to
acquittal."  As we understand defendant's argument, he posits
essentially that, because he committed the second murder while
under the influence of an extreme emotion disturbance, he should
have received the benefit of the affirmative defense provided in
ORS 163.115(1)(a).  In other words, the jury should have been
able to decide the merits of defendant's EED defense in
determining whether the state had proven all of the elements of
aggravated murder.  Although phrased differently, that argument
is almost identical in substance to the argument that the
defendant presented


not have that sentence suspended, deferred or commuted by
any judicial officer[.]"  The state argues that defendant relies
too heavily on the word "defer."  If defendant is correct, the
state argues, then any defendant the court sentences both to
death and to life without the possibility of parole is immune
from the death sentence.  The defendant, according to the state,
would be obliged first to serve the entire life sentence before
any other sentence could be executed.  Rather, the state
proposes, the purpose of ORS 163.105(1)(b) is to "preclude a
court from setting aside, staying or reducing the term of the
mandatory life sentence."  (Emphasis in original.)  Thus, the
state argues, when a sentencing court orders a defendant to serve
his life sentence without the possibility of parole consecutively
to his death sentence, the courtaccompanied by a struggle as to
who one is, or an inner battle regarding identity."  (Emphasis
omitted.)  The evaluation explained further that "[t]he major
symptom of identity alternation, is defined as 'behaviors that
are the manifestations of the assumption of different identities,
such as referring to oneself by different names[,] being told by
others that he or she has been acting like a completely different
person[, and] severe mood change (especially if accompanied by
amnesia).'" (Emphasis omitted.)  That defendant often went by
false names led Kirschner to conclude that defendant possessed
the symptoms for identity alteration.
Return to previous location.

8. We express no opinion whether Kirschner's testimony was
evidence that properly may be characterized as extreme emotional
disturbance evidence.
Return to previous location.

9. For example, the subpoena required, among several other
things, production of

"[a]ll records, including but not limited to
correspondence, e-mail,


to compete" under the merit promotion process. Joseph, 505 F.3d at 1383. Mr. Dean was given such an opportunity to compete and be considered by the Agency.
The Agency found Mr. Dean to be "qualified" for the position. Ms. Helen T. Cash, Supervisory Product Safety Investigator at the Agency, averred that she and another supervisor "did thoroughly review all of the applications for the position." Ms. Cash "considered the information in the applications, the previous history, and the interests of the individuals." Upon reviewing Mr. Dean's application, Ms. Cash found that Mr. Dean "appeared to be a job hopper and a floater." Ms. Cash also stated that "David Dean's application did not state why he wanted the job. His introduction showed no interest in the job, just that heFoundation awarded for fighting poverty in Vietnam

The Foundation's work to help eliminate poverty has been honoured with a special award in Vietnam.

Vietnam Country Manager Dr Huynh Tan Phuc accepted a Certificate of Merit at a ceremony in Hanoi recently, acknowledging the contribution of The Foundation's eye health programs to economic development in Vietnam.

The award was presented by the Vietnam Union of Friendship Organizations, the government body overseeing international development agencies.

"The Foundation has a magnificent record of achievement in Vietnam," says The Foundation's CEO Brian Doolan.

"Since Professor Fred Hollows first visited Vietnam in 1992, the number of cataract operations performed there has increased from below 1,000 to 160,000 per year.

"Of course none of this would be possible without the hard work of The Foundation's Vietnam team, lead by Country


and extension of follow-up by five additional years. In addition to the monitoring of the additional data collection and the management of the data, the DCC will have responsibility for continuing cross-sectional analysis of the already collected data and for implementing longitudinal analyses, drawing on the already collected data from the parent cohorts and from the data collected during follow-up of the SHHS participants. State-of-art methods for longitudinal analysis will be needed to test the primary hypotheses of the SHHS. To meet these challenges, a multidisciplinary team will be assembled to staff the DCC, including expertise in pulmonary and sleep medicine, epidemiology, biostatistics, and data collection and management. The specific tasks to be carried out include: 1) a smooth transfer of data and operations from the current DCCto the new DCC; 2) continued support of data collection by the SHHS clinical centers through monitoring of the data collection process and of data quality; 3) maintaining and extending the SHHS data management system in order to assure efficient archiving of high quality data and the development of analytic databases for use by the DCC and the clinical centers; 4) development of an analytic plan, in conjunction with the Steering Committee, for longitudinal analyses, including the use of pre-existing data from the parent studies; 5) development and implementation of a plan for coordination of data collection and analyses with the Sleep Reading Center; 6) provision of logistical support to the SHHS investigators, including the coordination of meetings and conference calls, the tracking of publications, and other SHHS


-shared -o extension.so extension.o -lphpcpp mysql_config --cflags --libs the compilation works fine.
I tried testing if the compilation really worked by using the defined function (ss_parse_table) from the extension. So I created a php file:
test.php
<?php
  print_r(ss_parse_table( "localhost", "dbuser","dbpassword","database"));
 ?>

and from the CLI when I run the command 'php /mnt/test/index.php' it works fine.
The command will output array returned by the defined extension function (ss_parse_table), something like this
Array
(
  [0] => Array
  (
    [id] => 'erd'
  )
)

but when I browse it from the browser the http fails
'No data received' (chrome error) or 'The connection was reset' (firefox error)

A:

I had exactly the same problem. I solved this by adding the directory where my libmysqlclient.so file is located to the system PATH:
PATH=$PATH:/usr/lib64

and then, restarting httpd service:
systemctlI spent way too much time on these and there really was no point to it. Except that I wanted to make Killer Queen do a bunch of silly domestic cat things. Like always being in the way and being a really clumsy hunter…


find good use for it whenever possible. There are many flavours of noise, from soft crackle (radio static, record scratches, optical film noise) over distortion (valves, guitar fx) techical noise (pink, white) to digital noise (jitter, bit crushers, buffer override, faulty media), and sometimes you need just a little bit of noise to bring the sound to life.
In my first feature film as supervising sound editor / sound designer / re-recording mixer, we had a scene, where it had to sound like the film itself was breaking apart. The picture was jumping all over the place, with lots of jump cuts and repeated footage, and since we were working in Dolby Digital, I thought digital errors were at its place. I used some automated bit crushing on thetime to download that data to the client than is necessary for the use-case.
In your example: it is indeed normal to store all user profiles in a single collection. Querying 6 users out of that collection will always take the same amount of time, even if you app grows to millions or hundreds of millions of users.


[A case of pulmonary Mycobacterium abscessus disease complicated with esophago-pulmonary fistula causing repeated exacerbation].
We report a case of fatal pulmonary infection caused by Mycobacterium abscessus in a middle-aged patient with acquired esophago-pulmonary fistula which contributed to repeated exacerbation. Acquired benign esophago-pulmonary fistula is uncommon. After a 55-year-old woman was diagnosed with pulmonary Mycobacterium avium disease in 1989 and improved with multidrug chemotherapy, she developed pulmonary M. abscessus in 2001. Despite multi-drug treatment, she suffered repeated exacerbation and her condition gradually deteriorated. Chest computed tomography (CT) showed esophago-pulmonary fistula which was comfermed by esophagoscopy. An M. abscess infection may give rise to adhesions between the tracheobronchial lymph nodes and the neighboring esophagus, with subsequent development of a traction diverticulum which may extend to the tracheobronchial tree. In the presentPersian model, prefiguring the tapestry Morris would
create five years later at Kelmscott Manor, and the foliated
borders of the Kelmscott Press books. However, this
gem-like private volume has an ethereal quality quite unlike
those later creations.

Horace: the Latin poet beloved by the Victorians

Horace was perhaps the most popular Latin author of the
Victorian age – graceful, balanced and astute, he was seen as
representing the values of the Victorian gentleman. He lived
during the reign of Augustus, between 65 BC and 8 BC, and
is regarded as the finest Roman lyric poet. His influence has
been tremendous, not least in the work of John Keats,
Christina Rossetti, Robert Frost, and Edward Fitzgerald in
the Rubáiyát.

'Every one of the Odes, as a rule, has a spirit,
genius, and movement of its own'WILLIAM GLADSTONE

The Odes consist of more than 100 short


is a wonderful facsimile of William Morris' hand-written and illuminated 'Odes of Horace'. What lifts this far above most fascimiles of this type is the excellent way the original metal (gold, silver) has been transferred into this fascimile. It's absolutely gorgeous. While the book was never finished by Morris, I also find it fascinating to see the contrast between finished and unfinished pages since you can see how he approached his work. I can't read the Latin original and from what I read, the translation chosen for the commentary volume might not be ideal since it seems to have bowlderized the Latin original, but in the end I enjoy the book simply for its beauty. What a treasure! I truly hope the Folio Society will publish more ofthat he has a massive headache because of this right now. It is not an easy decision. In Paris, he will be surrounded by his friends.

Premier League transfer round-up: Chelsea sign Real Madrid striker

He added: “That does not mean he is uncomfortable at Barca though. On the contrary, he actually feels very good there. Because of that, his choice has been made even harder.”

Andre’s comments came on the same day that Barcelona defender Gerard Pique suggested that Neymar would not be leaving the club this summer.

In an apparent attempt to end the speculation, Pique uploaded an image of himself with the Brazilian to Twitter alongside the caption: “He stays”.

Andre, however, would not be surprised if the deal eventually came to pass, and added: “How will it end? I


of disease and injury. [unreadable] The specific aims of the proposal are (1) to verify that cm-rep models can represent the hippocampus accurately, particularly in the presence of pathology; (2) to validate cross-subject normalization via the cm-rep method by examining how well it aligns hippocampal sub-fields; (3) to confirm preliminary findings indicating that shape-based normalization can improve the statistical power of group fMRI analysis; (4) to demonstrate that the cm-rep approach presents an improvement over volume-based and boundary-based methods for combined statistical analysis of hippocampal shape and multivariate/multimodal imaging data. These aims will be achieved by applying the new technique to simulated and real imaging data from functional and structural studies involving temporal lobe epilepsy, Alzheimer's disease, and schizophrenia. This exploratory research, if successful, will clear the groundfrom walking
there, though, as long as i lived there.

I think one aspect of this is the surprise that an engineer would get swept up
in this, but this isn't really something that can be solved by tech.

~~~
maram
>>Even before all of this tech, if you looked suspicious you would get stopped
or worse.

Tech is IMPROVING our lives. Software is an enabler, it solves our problems.
If the software is making our problems worse, then there is something wrong
with the software, we fix the software. But the issue here isn't the software,
the issue here is privacy invasion. Terms of Use and Privacy Policy aren't
comprehensive enough to inform users what they are doing or how and when they
are collecting their personal data.

From the story “I didn’t realize that by having location services on that
Google


have my connections, it'd be up to blind luck. That's the
reality for most criminal defendants.

They'll hire private council and think that because they're paying for it,
it's better. But it's often not. For a typical defendant with an aggravated
assault charge, a public defender has handled dozens of similar cases before.
Moreover, they'll have done it with your judge and your prosecutor. A private
lawyer probably won't have that. Granted, this probably holds a lot less for
the HN comments section.

I'll add that there is no right to defense council for civil cases. These can
have consequences just as dire as a criminal case, as in immigration or
eviction proceedings. An indigent defendant with no lawyer has a very poor
chance. There's a movement to create this right [1]. The current Supreme
Court, however, seems more likelypeople’s data and worry about the details later.

~~~
throwaway17_17
There is no constitutional issue in this case. This person gave their
information to Google and Google was asked for the information. There is no
4th Amendment protection for information a person gives to someone else. The
ACLU, EFF, and others have nothing to take further.

~~~
theluketaylor
The third party doctrine is badly outdated in the modern world where third
parties hold immense volumes of information about our locations and
interactions. Since it was a court ruling that brought the doctrine into
being, the passage of legislation or further court rulings can overturn it or
reduce the scope. There is absolutely work for groups like the ACLU and EFF to
do here.

Here in Canada several of our wireless providers banded together to fight an
incredibly broad request for information about everyone hitting


the long run come out ahead.
It is one of the few situations with no real tradeoffs.

------
x__x
So if he were using an old cellphone, before the days of apps, would he still
have been served a notice from the phone company for his phone tower location?

The article says: "drawn from users’ GPS, Bluetooth, Wi-Fi and cellular
connection"

and cellular connection.

~~~
bm98
_That_ is the question we should be asking. If not, is it because geofence
warrants have a higher legal bar if issued to a phone company? Or is it about
the level-of-effort?

------
sundvor
Bah, if riding with eg a Garmin or Wahoo it would clearly show there was no
stopping at the front of the house and that should be it.

If Google Fit is a bit like Samsung Health, it would probably stop an activity
at the spot ofbad guys in the situation.

~~~
theferalrobot
Yes the phone companies have data but it is far far less precise than GPS
which was required in this case.

Additionally, Apple does not collect your location data like Google does so I
am not sure why we should let Google off the hook.

~~~
ajross
You don't know that GPS was required, nor whether or not cell records were
subpoenaed as part of this investigation. All we have is what Google told the
guy in the story.

And as far as Apple, I don't think that's true. Apple has a location history
feature just like Google does. If that data ever reaches their machines in a
non-anonymized way, then it's subject to subpoena just like anyone else's data
is. Do you have a cite that explains why this is impossible?

~~~
theferalrobot
>You don't know that GPS


was required, nor whether or not cell records were
subpoenaed as part of this investigation. All we have is what Google told the
guy in the story.

I do know that because cell tower triangulation is on average only precise
within about a square mile, which is considered far too broad for these types
of searches.

>Apple has a location history feature just like Google does. If that data ever
reaches their machines in a non-anonymized way, then it's subject to subpoena
just like anyone else's data is. Do you have a cite that explains why this is
impossible?

Location history on ios is stored locally, not logged and stored by Apple. Any
data that is passed to Apple is anonymized. Per Apple:

"Where you go says a lot about you. Maps delivers a great experience without
Apple knowing which stores,.8), open-field locomotion time (P = .6), rotarod (P = .6), or anxiety (P = .7). Histologic evidence of white matter damage can be replicated using an LPS model for intrauterine inflammation. Significant phenotypic differences consistent with the motor and cognitive damage sequelae of such lesions (ie, CP) were not demonstrated. When evaluating animal models, it is important to assess not only biochemical markers for human disease, but also clinically relevant phenotypes.


fault of the players. All sorts of factors can contribute to a player being overlooked or undervalued in a popularity contest. To make amends, The Point Forward will endeavor to build the All-Ignored team, the best five-man line-up from the 70 players who were on the 2014 All-Star ballot but were not among the 50 leading vote-getters through round one. The All-Ignored team will aim for good shooting, solid defense, versatility and a cohesive fit.

(Note: All statistics through Dec. 17 games)

PG: Ty Lawson, Nuggets

Our first selection is a classic victim of a positional logjam. The NBA is in the midst of a point guard golden age, and the Western Conference is overflowing with riches. This year's voting leaderboard included, in order: Chris Paul, Stephen Curry, Jeremy Lin, Russelllikes of Kevin Garnett, Jeff Green, Carlos Boozer, and Paul Pierce, among others, is inexplicable. Can we please inspect the Fulton County voting booths for signs of tampering?

It's not exactly breaking news for a Hawks player, or even Horford himself, to be denied his just portion of the media spotlight. The team's paltry home attendance and reputation as a "good but never great" organization both push back against All-Star recognition and national popularity. The workmanlike nature of Horford's game is also a contributing factor: he's back on his grind, essentially replicating his 2012-13 numbers by averaging 17.8 points and 8.4 rebounds while shooting 55.1 percent, but he spends far more of his time ground-bound than above the rim.

Kudos to the Hawks for breaking through this continued anonymity by


Rich Cho

Charlotte Hornets General Manager Rich Cho. Mandatory Credit: Curtis Wilson-USA TODAY Sports

I have no evidence to back this up, but I bet General Manager Rich Cho is a fantastic poker player. Like Gregg Popovich and Bill Belichick, Cho tells reporters only what they need to know, and often less than that. Cho minimized free agency leaks, but you could be sure that once something did leak, Charlotte was making a move. Of players publicly connected to Charlotte during free agency, only Kirk Hinrich turned down a Charlotte offer. Cho read the tea leaves perfectly on Lance Stephenson. The Hornets made a strong play at Gordon Hayward, leaving no doubt of their intention to sign a wing. But after Utah matched, Cho waited until the Stephenson market wasafter the model was established. In this work, from the 20 samples in each treatment, 15 samples were used for calibration or model establishment, while the remaining five samples were used for prediction.

PLSR analysis proposed by Gerlach, *et al.* \[[@b17-sensors-13-13820]\] is widely used for calibration in current spectral analyses methods. Known as a bilinear factor method, PLSR attempts to find multidimensional direction in the spectral matrix (X) that explains the maximum multidimensional variance direction in the column vector (Y; \[[@b18-sensors-13-13820]\]. Both the spectra (response variables) and concentration (dependent variables) matrixes are decomposed simultaneously in the PLSR calculation. After the calculation, a set of orthogonal factors (latent variables, LVs) is projected. The first few LVs that are most related to predict dependent variables are then used for the model


were compared based on the selected variables. [Table 4](#t4-sensors-13-13820){ref-type="table"} shows the results of regression models for the quantification of NP adulterated by SFP, CF and the mixture of two adulterants based on the selected wavelengths. When visible spectra were used for the model calibration, good predictions were obtained by the CARS-LS-SVM models for Designs A and B with an average *r~P~* of 0.921 and an average RMSEP of 2.868%. The CARS-PLSR model obtained a similar result to the CARS-LS-SVM model for Design A, but its prediction for Design B was not as good as for Design A. Both CARS-LS-SVM and CARS-PLSR models failed for Design C, in which their RMSEP were larger than 4%. In general, the results of variable selection were acceptable for visible spectra. After mostabout the chances for a "yes" answer to question $(3)$.
Thanks for the responses so far.

A:

No, already for $p=q=2$, the infinite dihedral group
$$
C_2\ast C_2=D_{\infty}=\langle a,b \mid a^2=b^2=e\rangle
$$
is a counter-example.
Edit: We can take the matrices $$A=\left(\begin{array}[cc] .1 & -1\\ 0 & -1\end{array}\right)\quad\text{and}\quad B=\left(\begin{array}[cc].1&0\\ 0 & -1\end{array}\right).$$ Both have order $2$, but their product gives $$(AB)^n=\left(\begin{array}[cc] .1 & n\\ 0 & 1\end{array}\right),$$
so that $AB$ has infinite order.


118*(-2 + j/10).
59
Let g(f) = -3594*f + 61. List the prime factors of g(-1).
5, 17, 43
Suppose 3*o - 12 = v, 0*o + 1 = -o. Let s(g) = -g**2 - 6*g + 2. Let m be s(4). Let u = v - m. List the prime factors of u.
23
Let i = 1127 + -570. Let l = i + -365. List the prime factors of l.
2, 3
Let h(s) = 2*s**2 - 5*s - 2. Let n(r) = -r**3 + 3*r**2 + 4*r - 1. Let b be n(3). Let a = -6 + b. List the prime factors of h(a).
23
What are the prime factors of 465/2*630/525?
3, 31
Suppose 7*g - 6 = 4*g. Suppose -84 = -o - g*o. What are the prime factors of -2 + -1Cutaneous penile and perianal Crohn's disease treated with a combination of medical and surgical interventions.
A 73-year-old man presented with fistulizing cutaneous Crohn's disease of the penis and perianal area without involvement of the gastrointestinal tract. The disease failed to respond to topical clobetasol propionate and oral cyclosporin and methotrexate. A combination treatment of minocycline, thalidomide and prednisolone brought the disease under control and induced remission. Surgery with excision and skin grafting were required to produce cure.


Q:

How close is the EU to achieving a fully unified market?

The original goal of the EU was to fully unify its members' markets to achieve a situation where all trade barriers are eliminated. As of 2018, how close is the EU to achieving that goal, according to official EU statements?

A:

According to the Official Website of the European Union itself,

hundreds of technical, legal and bureaucratic barriers to free trade and free movement between the EU’s member countries have been abolished

However there are many obstacles remaining, such as

fragmented national tax systems impede market integration and undermine efficiency
separate national markets still exist for financial services, energy and transport
e-commerce between EU countries has been slower to take off than at national level, and rules, standards and practices vary considerably
thethrowing more race accelerant on the fire:

It’s funny that she’s so concerned about racism, especially since she routinely shares memes that many would consider racist:

Not me, because I don’t give a shit about words. But many would.

Then the story really took off. And as people started reading that the cops weren’t doing anything about the racially motivated lynching, SJWs weren’t liking that and demanded that the chief be fired for doing his job….

They even started a Change.org petition. So you know they mean business!

Except here’s the problem – this is black child who was allegedly the victim of a racially motivated hate crime:

We normally don’t share pictures of kids, but since Mom is putting him out there for the world to see as a victim of racism, the


their claim. Nevertheless, the DePenas’s recent submissions, including the attached
medical articles, have been considered.
                                                   3
of the immune system. These facts are the foundation for the subsequent
evidentiary analysis.

1. Rhone’s Early Health
      Rhone was born in 2003. Exhibit 9 ¶ 1. Until he was seven years old,
Rhone’s health was normal. See exhibit 5 (records from Northeast Pediatric
Associates) passim. He participated in typical activities such as swimming, biking,
playing tennis, and playing basketball. Exhibit 9 ¶ 2;   The pneumococcal conjugate vaccine is often referred to by its brand name: Prevnar.
The pneumococcal conjugate vaccine given to Rhone between 2003 and 2005 protected against
seven strains of the pneumococcal bacteria. Exhibit 21.11 (Pneumococcal Vaccination: Who
Needs It?, Centers for Disease Control and Prevention (Jan. 25, 2015),
http://www.cdc.gov/vaccines/vpd-vac/pneumo/vacc-in-short.htm.
       6
         A more formal name for pneumococcus is streptococcus pneumoniae. Tr. 268. For
consistency, this decision uses the term “pneumococcus.”


vaccine contributed to it.

       Near the end of Rhone’s hospitalization, the doctors tested Rhone’s blood
for the presence of titers against 14 serotypes of pneumococcus. For three strands,
Rhone had levels of antibodies that exceeded 1.3 μg/mL, which is considered the
threshold for protective levels. See exhibit 7 at 501 (results dated October 11,
2010); Tr. 97, 327, 334-36 (explaining protective level). One strand was 1.15
μg/mL. Rhone’s titers for the remaining antibodies were less than 1.0 μg/mL.
Exhibit 7 at 501.

      After recovering in the hospital, Rhone was discharged on October 18, 2010.
Exhibit 7 at 62-64; see also Tr. 27-28, 58.

5. Medical History after October 2010
       Rhone’s pulmonologist, Amanda M. Dove, followed his case for several
months.62.

      For some time after May 1996, Dr. Lokshin taught allergy to medical
students in large lecture classes at the University of Nevada, Reno. Exhibit 19; Tr.
73. Dr. Lokshin’s current teaching involves working with a single student for a
few weeks in his office. Tr. 74. His current employment, which started in 1995, is
working in a practice consisting of two doctors, called Allergy and Asthma
Associates. Exhibit 19; Tr. 63. He usually sees one patient or two patients with
pneumococcal pneumonia each year. Tr. 70.

      After the petitioners offered Dr. Lokshin as an expert in the relationship
between “T cells and invasive pneumococcal disease,” the Secretary objected. Tr.
68. The ensuing voir dire brought out that Dr. Lokshin is not board certified in
immunology. He


Dr. Romberg about multiple things that
undermine a primary role for T cells in fighting pneumococcal infection.
       As outlined below, both Dr. Lokshin and Dr. Romberg agreed that an
effective response to pneumococcal infection requires both the innate immune
system and antibodies from the adaptive immune system. Additionally, Dr.
Lokshin did not dispute that T cells do not respond directly to pneumococcal
infection (most likely because the external surface of pneumococcus is primarily
composed of polysaccharides). Further, Dr. Lokshin did not dispute Dr.
Romberg’s observations regarding humans suffering from X-linked
agammaglobulinemia and severe combined immune deficiency (SCID), which
strongly support the argument that T cells are expendable in the body’s response to
pneumococcal infection. In short, the following concessions by Dr. Lokshin
undermine his ability to maintain that T cells have a significant(Photo : Reuters) A man catches a nap in Beijing. Asian cities were found to be the sleepiest on the planet.

It's official: with an eye-watering average of just five hours and 46 minutes of sleep a night, Tokyo has taken the dubious title of the world's most somnambulant city.

Over the summer, poll-takers working for sleep-tracking company Jawbone monitored the sleep patterns - or lack thereof - in 45 cities. Asia, with its grueling work ethic and enormous pressure to win and climb up the social ladder, swept the top three. Staggering behind the Japanese capital are Seoul (five hours, 55 minutes) and Singapore.

Like Us on Facebook

Melbourne, Australia, came in with the most hours in dreamland, at seven hours and five minutes. All 45 cities were found to experience


through the
Tribulation, well after the
Church has been raptured up to
Heaven. Therefore, don't sweat
chips and barcodes and credit
cards. They have nothing
to do with the Mark of the
Beast...yet. Today's global
ecommerce network points to the
fact that Jesus Christ is
returning soon.
>>[music]
>>Sign number four is actually a
wonderful sign, for it's a
positive one. This sign
prophesies that the entire world
will be evangelized in the end
times.
>>God wants the
Church to preach the Good News
of His salvation to the entire
world, and so He's provided us
with powerful communication
tools for sharing the Gospel.
Today's exponential curve in
communications technology has
played a vital role in reaching
more of the world for Christ
than has ever been reached in
the previous nineteen centuries.
Technologies such as cameras and
microphones, televisions and
tablets, smart phones and cell
towers, communications networks
and satellites, the Internet and
the airwaves, big media, and
social media they all work
togetherto form the largest
pulpit the world has ever known.
And while all these breathtaking
technologies are leading people
to Christ by the thousands each
day, the entire world, as Jesus
referred to it, will not all
hear the Gospel before the
Rapture happens. That blessing
awaits the Second Coming at the
end of the Tribulation.
Communications technologies will
continue to spread the Gospel
to the post-Rapture world. In
addition, God will send forth
144,000 Jewish evangelists, the
Two Witnesses, and even
the Gospel Angel to preach
throughout the whole world.
Every person on the planet will
be evangelized by the end of the
Tribulation. God will leave no
person without a chance to
choose His Son and so be saved.
Today's communications
technologies point to the fact
that Jesus is returning soon.
>>[music]
>>The fifth sign involves the
living image
of the Antichrist.
>>Revelation reveals that during
the Tribulation the Antichrist
will order his False Prophet to
set up an image


biblical proof that the
Antichrist will rule from up in
orbit. But, with the space
station costing somewhere
between 150 billion and half a
trillion dollars, the ISS must
have more of a long-term purpose
than just seeing how earthworms
float. Today's space science
technologies point to the fact
that Jesus Christ is returning
soon.
>>[music]
>>The ninth and final sign of
technology
in this list actually has
to do with
technology's limitations. Have
you ever considered that our
technology has limits? It does!
For one, supplies of rare earth
metals are running dangerously
low. Did you know that the
computer, tablet, and smart
phone, that are surely an arm's
length away from you, are made
out of rare earth metals? The
metals used to make these
advanced technologies, those
technologies that we've become
so dependent on, can only be
found in certain places, and the
supplies are quickly dwindling.
Nearly 95% of these metals
can only be found in hostile
countries suchbe people
living in space stations, and
lunar colonies, and Martian
colonies, and extra-earth
settlements, or safely tucked
away on spaceships traveling
beyond our solar system. The
gathering of every human being
against Jesus at Armageddon, and
then again at the Sheep-Goat
Judgment, means that humanity
will still be confined to the
earth. Our optimistic hope of
settling outer space will not be
happening, at least in this age,
according to these limits set
in the Bible. Technology during
the Tribulation will have also
reached its limit. If four
prophesied catastrophic
earthquakes shake the world
apart, what will happen to all
the mountains? They will be
leveled. What happens to cell
towers during earthquakes? They
fall over. What happens when
solar flares burn the sky? The
radiation destroys the
satellites and interferes with
communications. What happens
when the oceans are filled with
blood and dead sea creatures
clog the waters? Ships can't
bring oil and goods to port, and
so distribution channels


Watch Outpost Hindi Dubbe Movie Online 720p 2008

Download Outpost Free In Hindi,Watch Outpost Hidi Dubbed Online,Live Streaming Outpost In HD In a seedy bar in a very city ravaged by war, mysterious man of affairs Hunt hires ex-marine D.C. to assemble a crack team of ex-soldiers to guard him on a dangerous journey into no-man’s land. to the present gang of hardened warriors, battle-worn veterans and borderline criminals killing is simply employment – and one they relish. Their mission – to scope out associate previous military bunker. It ought to be straightforward – forty eight hours at the foremost. ample money for tiny risk, just about he says. Once at the outpost, the lads create a horrific discovery that turns their mission on its head – the scenedisclosure makes that almost irrelevant. It is, at the very least, procedural incompetence on a breathtaking scale — the most astounding case of my lifetime, and I’m hard-put to think of a parallel in the entire history of science.

UPDATE: High drama! There’s a strong argument, based on the CRU dump, that the CRU’s claim to have lost the data in the 1980s has to be a falsehood. If so, we’ve moved from an incompetence-centered explanation back to a fraud-centered one. But then, a counterclaim that the reporting was bad and they’ve only destroyed 5% of their data. Pass the popcorn…


Art: Akapost on Tumblr

[Suspense][Adventure][Superhero][Incomplete][M-16]

By: Untraveled

Superheroes: Zootopia edition! Except this one ain’t some crossover with an existing superhero franchise or even an AU where the characters assume the roles of beloved superheroes of yore. Instead, Untraveled cooks up a tale in which every denizen of Zootopia has some kind of special ability — including Nick Wilde, who just got out of jail, and Finnick, who’s the first mammal he sees when he gets out. What ensues is an enjoyable story that delves into the powers each character as while unfolding a plot in which some mammals — such as one Judy Hopps — use their abilities for good against those who might consider the opposite path. Rated M for language/violence. ~YFWE

Description: Set in a world where every mammal hassuper powers. Nick Wilde is released from prison after 15 years. Branded a criminal and terrorist and bound by a red collar called a “Kill Switch,” the fox tries to piece together his life. His world is turned sideways once again when a friend is murdered and displayed on the steps of the Hero Association, where the killer left Nick a message.

Fanfiction.net

Archive of Our Own

Additional tags: not every hero wears a cape haha get it because a lot of them are just plain ordinary mammals also remember what edna mode said about capes???


by them. As I write, two of them hang on the wall of my room. I suppose they’re unremarkable to look at, with their pale blues, dull tans, vast expanses of white for deep water, and thousands of minuscule numbers everywhere, indicating depth. I think they are magical, and when I look at them, my imagination explodes. When I look at them, I taste salt air. The inscrutable depths swell beneath me, and pirates and sea monsters are possible.

Now, my grandfather is battling his final monster, the one that will get him, that will finally accomplish what all of Nazi Germany couldn’t manage. He survived the B-17, exploding ordnance, a crash-landing in Iceland, to wash up at last on the alien shore of the disease that is eatingTake Control, We Got This. [Eating For the Anxious: Part 10]

Today I decided that next year I am going back to school to become a registered dietitian, RD. This is a BIG revelation/decision for me, as I had insisted to myself that I would never need to go back to school (this will be my fourth school and fourth major, mind you). But hey, feelings change, goals change and I believe with a serious intensive education (cause oh boy it’s going to be intense) I can have the opportunity to help more people. Not only will I be open to more opportunity but I can combine a formal education in nutrition with my holistic education and essentially be a well rounded holistic dietitian/nutritionist. In the mean time I


knowledge and have been inspired to put more content out there. I am so insanely passionate that sometimes it hinders me from diving into something. Well..I dove, and I didn’t sink! I hope that if you are also struggling to cultivate an energy to put content out there (no matter what it may be) that this inspires you a little. These posts in this series came from someone with anxiety and extreme self-doubt. Not someone who has all their shit together.
I’m rambling, aren’t I?

My point: I only desire that my passion and honesty leaks through these posts and you find some healing. I know I will be using these for my own benefit.

I hope that this series has shown you that there are SO many other ways toFox News host Sean Hannity offered to let WikiLeaks founder Julian Assange guest host his radio show after Assange floated the idea of starting his own show or podcast.

Hannity was responding to a tweet from the WikiLeaks founder, who said on Twitter that several "U.S. networks" have suggested he start his own broadcast.

"Several U.S. networks suggest I start a weekly radio broadcast/podcast from within the embassy siege. A good idea? Ideas for format, title?" Assange tweeted.

Hannity said it was a "great idea" and offered a potential name for the series: the "JA Show." The Fox News host, whose radio show airs for three hours in the afternoon, then suggested Assange could take over for him one day.

"@JulianAssange If you would like to fill in for me one day


recipe based upon one for ages, but I haven’t managed to get the dish quite right. Perhaps I should revisit it, because it’ll be excellent for fall/winter.

Archives

All rights reserved by Michael Procopio.
Although I think it's lovely that you may wish to print poster-sized versions of my images and tack them on the ceiling above your waterbed, I strongly advise against it.
And though imitation might be the sincerest form of flattery, plagiarism is not. So it should come as no surprise to you that I should declare that this material may not be published, broadcast, rewritten or redistributed without permission.
Thank you.The quantification of RNA expression provides major insights into analysis of cellular metabolism, function, growth and interactions. Although individual RNA species have historically been the subject of these studies, more interest is currently being shown in analysis of the patterns of the simultaneous expression of multiple RNA species of both known and unknown function. This approach allows comparative studies on the patterns of expression between different populations of cells, thereby serving as an indicator of the differences in biochemical activities taking place within these populations. For instance, a single group of cells can be divided up into two or more populations where one group serves as a control and the other part is exposed to drugs, metabolites or different physical conditions. In this way, although the majority of


nucleotides contain chemically active substituents such as allylamine modifications, post-synthetic modification can be carried out by a chemical addition of a suitably labeled ester.
The synthesis of a cDNA copy from an mRNA template essentially results in a one to one molar ratio of labeled product compared to starting material. In some cases there may be limiting amounts of the mRNA being analyzed and for these cases, some amplification of the nucleic acid sequences in the sample may be desirable. This has led to the use of the third approach, where the cDNA copy derived from the original mRNA template is in itself used as a template for further synthesis. A system termed “Transcription Amplification System” (TAS) was described (Kwoh, D. Y. and Gingeras, T. R., 1989, Proc. Nat.Dyslipidaemia and lipoprotein pattern in systemic lupus erythematosus (SLE) and SLE-related cardiovascular disease.
This study focused on lipoprotein composition and properties in systemic lupus erythematosus (SLE). The size distribution of plasma lipoproteins was studied by nuclear magnetic resonance (NMR). Cholesteryl ester transfer protein (CETP) activity was determined by enzyme-linked immunosorbent assay (ELISA). The affinity of low density lipoprotein (LDL) for proteoglycans was assayed. Twenty-six women (aged 52+/-8.2 years) with SLE and a history of cardiovascular disease (CVD) (SLE cases) were compared with 26 age-matched women with SLE and without CVD (SLE controls) and 26 age-matched population-based control women (controls). Very low density lipoprotein (VLDL) particles (nmol/L) were more prevalent among SLE cases than SLE controls (0.039) and tended to be more common in SLE cases than in controls (p


could create an even more frightening scenario than the UK tabloid newspapers' ‘phone hacking’...

Robotic technology is quietly transforming the world of agriculture and will grow to become a $45 billon industry by 2028, according to the IDTechEx (www.IDTechEx.com) research group.

Tractor guidance and autosteer are well-established technologies. In the short to medium terms, both will continue their growth thanks to improvements and cost reductions in RTK GPS technology. IDTechEx estimates that around 700,000 tractors equipped with autosteer or tractor guidance will be sold in 2028.

Unmanned autonomous tractors have also been technologically demonstrated with large-scale market introduction largely delayed — not by technical issues but by regulation, high sensor costs and the lack of farmers' trust. This will start to slowly change from 2024 onwards, though the sales will onlyto provide the underlying connectivity for the future high growth of connections, spurred on by the enabled emerging use cases.

Juniper says that smart city development will hugely benefit from LPWA (Low Power Wide Area) access technologies, forecasting that over 25% of cellular smart city devices and applications will operate over these networks by 2022. The low cost per connection of LPWA networks and a battery life of 10 years will become appealing for monitoring city...

The technology divide between older and younger generations may not be as wide as you think. According to a recent survey of 1,000 seniors issued by Senior Helpers (www.seniorhelpers.com), aprovider of in-home senior care, more than 68 percent of people ages 65+ rate their technology skills either average or above average.

The survey, which examined


a $87 billion market in 2028. Komatsu, John Deere, Caterpillar, and others manufacture the big vehicles — mainly hybrid — while other manufacturers offer smaller, pure-electric versions.

Pure electric is a legal requirement indoors. Outdoors, fuel saving and better performance attracts. Cranes and man lifters have many applications. Their production volumes are larger than most people realize. So it is with the electric versions set for over 164,000 to be sold in 2028, says IDTechEx.

The research group says this is an industry about to change radically. For example, in mining, over 90% of the world's mines are open cast. They are often in remote places up to 4,000 meters above sea level, where shipping diesel can cost more than buying it. Consequently, there is now a move to havethan 10% can claim that they are in a...

The Spy thinks he understands a little about a lot of things, and quite a bit about a few things, but he does not understand...

Why are some people's reactions are so ridiculously extreme?

Leaving ordinary politics (if there is such a thing) aside for the moment, and as detailed here last month, the Spamhaus reaction to spam emanating from a handful of servers at the NewTek/Deerfield/Atjeu facility was to ban an entire range of 65536 IP addresses. Despite NewTek's and the Spy's efforts, nothing can persuade the Spamhaus boffins to be more reasonable and ameliorate this. The Spy has now dropped Spamhaus from his server's mail scanning RBLs. Given their policies are this arbitrary, they cannot be relied upon to accurately


their mobile devices.

When it comes to the industry recommended practice of two-factor authentication, a staggering 75% of Americans revealed they had not implemented this feature to protect their personal information on their devices. Just 32% of Americans who have heard of any news stories about security breaches in the...

Canalys (www.canalys.com) forecasts that standalone smart VR headset shipments will pass 1.5 million in 2018, and grow with a compound annual growth rate (CAGR) of 140% to reach 9.7 million units in 2021.

Oculus, HTC and Lenovo are launching new standalone headsets aimed at different market segments, which will drive rapid market growth. Standalone VR headsets are expected to help push the VR headset market to 7.6 million units in 2018, twice the shipments forecast for this year, according to Canalys.100% of the time. Now that we know that both games are primed to hit our mobile screens... | Read more »

Apple is now offering Certified Refurbished 2017 10″ and 12″ iPad Pros for $100-$190 off MSRP, depending on the model. An Apple one-year warranty is included with each model, and shipping is free:
–... Read more

Silver 12″ 1.3GHz MacBook on sale at B&H...

B&H Photo has the 2017 12″ 1.3GHz Silver MacBook on sale for $1399.99 including free shipping plus sales tax for NY & NJ residents only. Their price is $200 off MSRP, and it’s the lowest... Read more

MacTech is a registered trademark of Xplain Corporation. Xplain, "The journal of Apple technology", Apple Expo, Explain It, MacDev, MacDev-1, THINK Reference, NetProfessional, Apple Expo, MacTech Central, MacTech Domains, MacNews,


and 8), which constitutes a total population of over 800,000 people. In total, the majority of the patients resided in district eight (n = 88) within approximately 6 km of the hospital. There was no significant change in the locality of patients over the three periods, or any relationship between serotype and location of the residence of the patients.

![**The distribution of the residences of cases of childhood shigellosis admitted to the hospital for tropical diseases in Ho Chi Minh City**. Over the three periods we were able to positively identify infecting *Shigella*serotypes in the stools of 297 children with symptoms consistent with shigellosis. Of these patients, 228 (76.8%) children lived in the 23 districts that constitute Ho Chi Minh City. This figure represents the distribution of the homesper day          10 (5 - 10)      8 (5 - 10)         0.051
  Convulsions (%)                    9 (7.3)          21 (14.3)          0.07
  Known pretreatment (%)             7 (5.7)          7 (4.8)            0.585


development and deployment of *Shigella*vaccines may be hindered by the number of different species and serotypes circulating in one setting and in differing locations. For example, *S. flexneri*serotypes are known to fluctuate over time, this has been observed in India, Indonesia, Bangladesh, and Pakistan, \[[@B10],[@B28]\]. Here, we have demonstrated a significant longitudinal transition of species from *S. flexneri*to *S. sonnei*. Vaccine development for shigellosis is challenging as primary infection offers only serotype specific immunity \[[@B29]\]. A study concerning a cohort of Chilean children found infection conferred 76% protective efficacy against re-infection with the same serotype \[[@B30]\]. An option for controlling shigellosis would be the development of a series of single serotype vaccines which could be implemented in individual locations with a known serotype profile. Alternatively, the most costspecialist roles. But there may be individual exceptions. In Uganda for example, senior NPCs are also assigned managerial, educational, and supervisory roles in the lower tiers of the health system. Again, empirical studies could be a good way to move forward.

Does the Increasing Clinical Burden Permit us to Leave Physicians Untrained for Their Non-clinical Roles? {#s5}
=========================================================================================================

Dovlo et al criticize our proposal "to train all physicians with managerial, mentoring, and supervisory skills, whether they will need them or not." They deem that proposal blind to medical students' already burdened curricula, given the "double burden" of communicable and noncommunicable disease and new attention to "lifestyle and behavioral conditions." Not all graduates, they emphasize, will require these non-clinical skills.^[@R4]^ Binagwaho et al declare, more conditionally, "we, therefore, advocate that education in


used yet it's maskSize will be 0 this.maskSize = 0; // And we have to start it's coordinates somewhere, they may as well be (0,0) this.mousex = this.mousey = 0; // Now we're set up let's build the necessary compoonents // First let's clone our original image, I'm going to call it imageZoom and save it our Zoombini this.imageZoom = this.image.cloneNode(); // And pop it next to the image target this.image.parentNode.insertBefore(this.imageZoom,this.image); // Make the zoom image that we'll crop float above it's original sibling this.imageZoom.style.zIndex = 1; // We don't want to be able to touch it though, we want to reach whats underneat this.imageZoom.style.pointerEvents = "none"; // And so we can translate it let's make it absolute this.imageZoom.style.position = "absolute"; // Now let's scale up our enlargedHonor, etc... all rolled into one!

Sunday, November 10, 2013

Moments Precieux was a suprise from the last two days. I had the blank notebook lying about for weeks, meaning to paint it...but then time kept slipping by and I had the cute fabric covered book from AMS that I added stuff, to personalize...but it's not the same. I need my archives to be arranged properly...But I was lacking ideas, until Venus went to Capricorn and I just wanted to do it. I figured I could play around with my stuff, until something hits. With collage, it's sorting out a puzzle and scavenging for the pieces.

Usually, I will have one hint, like the title, a concept or actual visuals--or a combo of the three. I love when it comes together


Q:

How to get last row from column in a specific range

I have some code that opens an excel spreadsheet and gets the last empty row in that column. The problem I am having is that I have two tables created in my excel spreadsheet. I want to be able to only select the range of B7:B94 for column B  as I have data that represents another table starting at B:101
Here is my code so far...
Const xlUp = -4162

Set xlApp = CreateObject("Excel.Application")
With xlApp
    .Visible = False
    Set xlWB = .Workbooks.Open("M:\Shared Documents\Job Cost Analysis\Hi-Tech BPO\Logs\" & currentMonth & "-Summary Hi Tech BPO.xlsx", , False)
    Set ws = .Worksheets(sheetName)

Dim LR
 '''''''''''Here is where I want to select the range ofAll relevant data are within the manuscript and its Supporting Information files.

Introduction {#sec001}
============

Various methods have been employed in oil recovery that comprises of: primary phase, which utilizes natural energy forces of reservoir for oil recovery, secondary phase includes the injection of water that pushes the oil towards the production well. After this recovery, remaining crude oil in the wells makes up to two-third of the total oil reserves. The present method of oil recovery is based on surfactant flooding, polymer flooding, alkaline flooding, and injection of steam (reduces the viscosity of oil and facilitating the recovery of oil) \[[@pone.0229889.ref001], [@pone.0229889.ref002]\]. Chemical and thermal methods are not economically feasible and therefore may affect the reservoir environment \[[@pone.0229889.ref003]\].

Current global energy production through oil is about 80--90%. During the primary process


1996. The study was reviewed with the OECD principles of Good Laboratory Practices & ISO 17025.

Core flood assay {#sec011}
----------------

The core flood experiment (an experiment under simulated oil reservoir conditions) was performed at IRS, ONGC, Ahmedabad to determine the water cut and selective plugging of permeable zones of the reservoir with isolated consortia TERIK. The characteristic conditions used in the study were described in [Table 1](#pone.0229889.t001){ref-type="table"}. The core was saturated with the formation water and crude oil. The original oil in place was around 12.6 ml. The formation water was flooded till the point; no oil was coming out of the core that shows the pore volume of the core which was around 21.1ml. Subsequently, TERIK consortia (1 x 10^6^ CFU) along with the media were injected and theand gases produced by micro-organism plays significant role in the mobilization of crude oil.

The efficiency of bio-surfactant produced by consortia TERIK was determined by estimating its impact on the surface tension of the media. The surface tension was reduced from 70 to 34 mNm^−1^ after 10 days of incubation, which demonstrated 51.4% of overall reduction. Biosurfactant are amphiphilic molecules which reduce the surface tension between oil-water/oil-rock interfaces and furthermore alter the wettability of the reservoir which leads to the mobility of trapped oil. The biosurfactant produced in this study further supports the enhanced oil recovery by giving positive oil spreading and drop collapse test (S1-S3 Figs in [S1 File](#pone.0229889.s001){ref-type="supplementary-material"}). According to Maneerat et al., 2007, they had screened emulsification activity of biosurfactant produced by various bacterial strains and


tested in the oil wells of Gujarat and Assam. The increment of threefold in oil recovery has been reported \[[@pone.0229889.ref011]\].

Conclusion {#sec020}
==========

The isolated consortia TERIK had potential towards the enhanced oil recovery in the high temperature reservoir. TERIK was selected based on its capabilities to produce the substantial amount of biomass and other secondary metabolites (volatile fatty acid, and biosurfactant). Furthermore, the consortium had ability to reduce surface tension from 70 to 34 mN m^-1^. TERIK was characterized to be *Clostridium* sp. The oil recovery efficiency of TERIK was tested in a core flood assay in which produced biomass interacted with the porous medium of the core that brings about the plugging and facilitating around 19% of enhanced oil recovery. This study confirms the importance of TERIK for oilMarketing Decisions: Right, Wrong, or None of the Above

Marketing Decisions are sometime made in a moment; other times, it days, weeks or months to make a firm decision… if one is made at all. This is a challenge for wedding professionals and wedding couples.

A wedding couple’s decision making process, if viewed from the position of a wedding professional often feels mind boggling. What should be a ‘no-brainer’ or so we think, looks quite confusing to the couple. The reason is simple: In most cases, the wedding is a first-time event, involving hundreds of choices, large and small, offered up to a couple with little or no experience… IN DECISION MAKING.

While business owners and managers may condescend to couples that waffle over choices, wedding professionals suffer from the same


Expression of beta-galactosidase gene and endothelial nitric oxide synthase gene in rat vascular smooth muscle cells after in vitro lipotransfection.
The aim of this study was to optimize the conditions for in vitro lipotransfection of rat vascular smooth muscle cells (VSMC) with bacterial beta-galactosidase gene and bovine endothelial nitric oxide synthase (ecNOS) gene. Transfection efficiency of four liposomes: Transfectam, Lipofectin, Unifectin-10, and Maxifectin was compared. The best results (efficiency 1-5%) were obtained with Maxifectin, when transfections were performed in VSMC cultures being at 50% confluency, with 1 microg DNA and 10 microl liposome per well, and when the liposome/DNA complexes were coincubated with the cells for 24 h. This method allowed detection of the transgene activity 12 h after the beginning of the transfection, with maximum values between theCrunch is a card game for 2 to 4 players that allows you to experience the upside of down. Placed in the role of a global banking CEO, you have to juggle the conflicting demands of your ailing bank and your flourishing bank account.

Along the way, the game also replicates our modern banking system and foreshadows the inevitable collapse of capitalism, but that's just a bonus.

Thursday, March 26, 2009

1. My brother in law *forgot* to tell my hubby and I that their mother is coming up and staying overnight with us...TODAY!!! Suprise!

2. My mother in law is spending the night tonight.

3. I let Darling get *one* box of Cookie Crisp (after swearing my children would never eat Sugar Coated Gritties) and now she wants to eat nothing else.

4.


improving energy and economic security while achieving significant environmental benefits. Over the next several years, cellulosic renewable fuel will grow into a sizable commercial industry.

In essence, using domestically produced raw materials to make renewable fuel works for America — and puts Americans to work. The RFS has brought us cutting-edge renewable energy technologies that will help make American energy cleaner and more secure while creating jobs in rural America. Cellulosic biofuels have made the transition from the laboratory to commercial production and are a key element of the Union of Concerned Scientists’ plan to cut half of projected oil use over the next 20 years. These fuels could contribute the equivalent of more than 1.5 million barrels of oil per day by 2035, and, combined with improvements inand shall not disclose your personal information to any third party, unless required by any applicable law or by the lawful order of any authority, court or tribunal. Our Player Limitation options involve a joint commitment from Us and you. Can you play Slots Magic from Mobile? Withdrawals will be investigated in line with any or all applicable legislation on Anti Money Laundering and counter terrorism funding practices. Wenn Sie einen exklusiven Gratisbonus erhalten haben, können Sie Ihr Geschenk in wenigen Augenblicken nutzen. Du kan även scrabble online two player följande tecken: Contractual obligations already nano karte stanzen shall be roulette casino ohne anmeldung. We offer a facility within shake your booty slot machine online casino Casino party deko to help you if you feel that your gambling


work. Where required by law, Your personal data may also be disclosed to an applicable governmental, regulatory, sporting or enforcement authority. For transaction security we use bit SSL data encryption, the same technology used by popular credit and debit card companies. Wenn Sie Ihre Einzahlung vornehmen, geben Sie einfach den Code in das BONUS-CODE-Feld ein und profitieren Sie von Ihrem zusätzlichen Guthaben! The minimum deposit requirement is subject to change at any time.Q:

Storing a dynamic variable for Workflow in SPD 2013

I am new to Share Point designer 2013. I would like to Store a value to a variable as follows:
Store 'field' in 'Variable'.
When compared in SPD 2007, there is "Build Dynamic String" under Actions. But in SPD 2013 there is no "Build Dynamic String" under Actions .
Also I need to know what workflow can be used for 'Stop Workflow' in SPD 2013.
Could you please help me to find a solution for the same?

A:

We can store the field values into a workflow variable.
For that first we need to create a variable and then assign values into it.
1. Create a workflow variable: From the ribbon you can select local variables and create as shown in below image.

2. Assign values to variable: From


Q:

Justify-content in flexbox not working in IE 11

I am trying to get an element to align to the right. I've used flexbox as I've found it easiest to align the text and any icons perfectly. The code snippet below is an example of what I am doing. The code works perfectly in Firefox and Chrome, but the justify-content is not working in IE. I already have "-ms-flex-pack" but it is not doing anything. The content is left-aligned in IE instead of being right-aligned.

.align-right {
    display: -webkit-box;
    display: -ms-flexbox;
    display: flex;
    -webkit-box-align: center;
        -ms-flex-align: center;
            align-items:Proposal of Polish guidelines for conducting financial analysis and their comparison to existing guidance on budget impact in other countries.
Financial analysis (budget impact analysis, BIA) is increasingly required by decision-makers to ascertain the macroeconomic consequences of new product reimbursement in addition to proof of cost-effectiveness. Poland is in the process of drafting country-specific guidelines for BIA, positioned as complementary to economic evaluation in decision-making The aim of this article is to present the Polish project and compare it with currently available guidance. A checklist was developed that focuses on issues that are unique to BIA. An analysis of the differences between different national guidelines and their Polish counterparts was subsequently undertaken. The Polish project of BIA guidelines is composed of two sections. The first section presents the objective,


large segmental duplication is the primate major histocompatibility complex (MHC) \[[@B5]\]. Other mechanisms that generate segmental duplications are transposition and retrotransposition events. As transposition is a \"cut-and-paste\" process, it is not likely that transposition results in a duplication events unless it is associated with lateral gene transfer (LGT). In specific cases, \"cut-and-paste\" transposition can result in duplication i.e. if it occurs in germ cells prior to meiosis and moves DNA from one chromosomal set to the other. LGT seems to be frequent only in bacteria and archebacteria \[[@B6]\], in which it can generate duplication. On the other hand, retrotransposition seems a frequent event in many eukaryote lineages. In metazoa, the maximum size of the duplicated segment corresponds to a transcript messenger (with the exclusion of *C. elegans*, inproposed that slowly evolving genes have a tendency to generate duplicates. Indeed, duplicated genes in the genomes of *Saccharomyces cerevisiae*and *Caenorhabditis elegans*have much slower rates of amino acid substitution, insertion and deletion than single copy genes. However, authors concluded that it is still unclear whether fixation, maintenance, or both of these steps together cause the bias towards the preferential duplication and highlighted that the relative importance of these two steps depends largely on the frequency with which duplicate genes are fixed by positive selection \[[@B15]\].

Duplication rate is also hard to estimate because of the difficulty in distinguishing true newly born duplicates from old ones that appear young because of gene conversion. Gene conversion is a homogenizing process between two homologous DNA fragments occurring during recombination. The divergence between


(*e.g.*, olfactory receptor families) may be partly explained by this process.

### Subfunctionalization *via*specialization

Several authors have shown that neither neofunctionalization nor subfunctionalization alone can adequately account for retention. Analysis of the genome-wide patterns of yeast protein interaction and human gene expression for duplicate genes has revealed rapid subfunctionalization accompanied by prolonged, substantial \"*stricto sensu*\" neofunctionalization in a large proportion of duplicate genes, suggesting a new model, termed \"sub-neofunctionalization^\"^. A possible biological explanation is that subfunctionalization could be followed by neofunctionalization with positive selection because of the pleiotropic constraint release \[[@B18],[@B22],[@B42]\]. However, we could also consider that the term \"specialization\" would be more appropriate in this particular case.

### Gene duplications and genetic robustness

Genetic robustness can be defined as *(i)*the ability of a biological system to withstand mutations due to redundancy,is no such conflict, and therefore the subfunctionalization could have been positively selected.

#### Subfunctionalization and genetic robustness

Hickman and Rusche \[[@B60]\] studied the duplicated histone deacetylases Sir2p and Hst1p in *S. cerevisiae*and found that these paralogs with non-overlapping functions could confer genetic robustness against null mutations through a substitution mechanism. Hst1p is a NAD(+)-dependent histone deacetylase that acts with Sum1p to repress a subset of mid-sporulation genes. However, the mutant deleted for hst1 showed much weaker derepression of target loci than the mutants deleted for sum1. The authors showed that this weak derepression of target loci in hst1Delta strains occurs partly because Sir2p substitutes for Hst1p. Sir2p helps to repress the mid-sporulation genes only in the absence of Hst1p and is recruited to target promoters by a physical interaction


paper.

Reviewer\'s comments
====================

Reviewer\'s report 1
--------------------

### Dr. Etienne Joly, IPBS, UMR CNRS 5098, Toulouse, France

This reviewer provided no comments for publication. The authors are grateful to the reviewer for helpful suggestions.

Reviewer\'s report 2
--------------------

### Dr. Lutz Walter, German Primate Center, Goettingen, Germany

This informative review discusses mechanisms and consequences of genome evolution through duplications. The authors considered both whole genome and segmental duplications. The evolutionary consequences are discussed and the authors consider favouring as well as opposing mechanisms to fix and maintain such duplications. I have only a minor point concerning the fixation and maintenance of duplicates. This is a central point of the manuscript and, therefore, should deserve more description than just a few sentences. Examples maybe helpful for the readers.

Author\'s response
------------------

We completely agree with the comment of Dr. Walter aboutconsisted of C.K. taking notes before putting anything into script form, was a pleasurable experience for the comedian.

“I enjoyed again sitting down and writing,” he said. “I didn’t want to do a season that the point of the season was I need another season. I wanted to have a story that I really wanted to tell, so I think that time off helped that way.”

C.K.’s talk with Carter provided insight into the unorthodox way that the series is filmed.

“The first episode back is kind of a dumping ground of many little things that didn’t end up in an episode,” he explained, while promising that the rest of the season will have a more cohesive nature.

Viewers can expect a season that improves upon the earlier three, if C.K.’s promises


Selective muscarinic antagonists. I. Synthesis and antimuscarinic properties of 4-piperidyl benzhydrylcarbamate derivatives.
A series of 1-substituted-4-piperidyl benzhydrylcarbamate derivatives were synthesized and evaluated for binding affinity to M1, M2 and M3 receptors, and for antimuscarinic activities. Receptor binding assays indicated that 1-benzyl-4-piperidyl benzhydrylcarbamate derivatives showed higher affinities for M1 and M3 receptors, and good selectivities for M3 over M2 receptor, than the corresponding ester analog. These results indicate that the urethane bond is a novel linker for muscarinic antagonists, and serves to lock the molecular conformation and allows the hydrophobic portion and cationic site of the molecule to bind to M1 and M3 muscarinic receptors. Among the prepared compounds, 1-(4-methylaminobenzyl)-4-piperidyl benzhydrylcarbamate monohydrochloride (18b, YM-58790) exhibited potent inhibitory activity on bladder pressure in reflexly-evoked rhythmic contraction, comparable to oxybutynin and was/*
 * This file is part of TechReborn, licensed under the MIT License (MIT).
 *
 * Copyright (c) 2020 TechReborn
 *
 * Permission is hereby granted, free of charge, to any person obtaining a copy
 * of this software and associated documentation files (the "Software"), to deal
 * in the Software without restriction, including without limitation the rights
 * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
 * copies of the Software, and to permit persons to whom the Software is
 * furnished to do so, subject to the following conditions:
 *
 * The above copyright notice and this permission notice shall be included in all
 * copies or substantial portions of the Software.
 *
 * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY


Q:

Python: 'other_activity' is not defined

I want to print the other_activity if its not empty after taking input from user but this error, I know its pretty basic but not able to find the solution
print("What kind of activity is this?")
print '\n'.join(acti)

userInput = raw_input("\n""Client->")
r = re.compile(userInput)
if not filter(r.match, acti):
        print("not valid activity")

else:
    if (userInput == "Other"):
        event_activity = raw_input("-> Please specify your activity\n""Client->")
        other_activity = ("Other:" + event_activity)
    else:
        event_activity = userInput

if not other_activity:
    print("Activity type: ", other_activity)
else:
    print("Activity type: ", event_activity)

A:

Define other_activity =from a class definition:
A_PROPERTY(int, Age)

The MACRO works, but creates a "getNAME" method instead of "get(whatever I put in NAME)". It seems MACROS don't parse strings and "parameters" together very well. Is there a way to achieve what I want? or should I just have the method as "NAME" with a different signature to differentiate the get and the set?

A:

Use ## to stitch tokens.
#define A_PROPERTY(TYPE, NAME)                            \
    private:


do this is with a semaphore.  You need a object accessible to each thread instance. A class level private variable private object sharedMutex = new object(); would work.  Then the code ExtractEmails(strippedResponse); should be changed to
lock(sharedMutex)
{
    ExtractEmails(strippedResponse);
}
Without having the code for the ExtractEmails(<string>) method, I can't provide a thread safe implementation for that, so that part of the solution may still cause a problem.

33 F.3d 1383
U.S.v.Anderson*
NO. 93-9198
United States Court of Appeals,Eleventh Circuit.
Aug 16, 1994

1
Appeal From:  M.D.Ga.

2
AFFIRMED.

*
 Fed.R.App.P. 34(a);  11th Cir.R. 34-3


Deals of Prom Limo Rental Near Me in Clarksville

Real Reviews From Real Customers

Demanding Rides

I hired Global Limos, Clarksville 10-12 passengers` limousine for my anniversary party. I got a promotional deal for the limo and an additional discount in a special deal running for the day. Our driver and the company were supportive to us.

Reviews

Customers rated this pro highly for work quality, value, and professionalism.

5

1 reviews

5100%

40%

30%

20%

10%

Jonathan Arsuaga

Demanding Rides

I hired Global Limos, Clarksville 10-12 passengers` limousine for my anniversary party. I got a promotional deal for the limo and an additional discount in a special deal running for the day. Our driver and the company were supportive to us.gave informed consent and received course credit or payment.

The distracter stimuli consisted of two videos of a female speaker saying *heed* or *hood* (see Fig. [1](#Fig1){ref-type="fig"}). The video stimuli were recorded by a 29-year-old female speaker of British English, with a Canon Lagria HF G30 video camera on a tripod. The video recordings were edited using iMovie on an Apple iMac, and scaled down in resolution from 1920 × 1090 to 1280 × 720 in .avi format. The prompt was a jpeg image with a resolution of 300 dpi, 0.38 × 0.16 cm (45 × 19 pixels), was presented on-screen at a size of 1.1 × 0.5cm, and consisted of either *heed* or *hood* printed in boldfaced Arial font on a black background. Font size was adjusted so


ms (incongruent minus congruent pairs) pooled across the video, audio, and audiovisual conditions, for each SOA and separated by prompt, for Experiment [1](#Sec1){ref-type="sec"} (top) and Experiment [2](#Sec4){ref-type="sec"} (bottom). Error bars represent one standard errorTable 1Averages plus standard deviations (in parentheses) for % error and response times in ms for congruent and incongruent stimulus pairs, per prompt, per stimulus onset asynchrony (SOA), and modality, for Experiment [1](#Sec1){ref-type="sec"}ErrorsResponse timesVideoAudioAudiovisualVideoAudioAudiovisual*HeedCongruent*SOA121 (41)26 (44)25 (44)648 (123)648 (123)606 (140)SOA25 (23)13 (33)10 (30)590 (115)590 (115)537 (130)SOA34 (20)12 (33)5 (22)534 (103)534 (103)558 (144)SOA44 (19)6 (24)7 (26)535 (85)535 (85)498 (109)*Incongruent*SOA119 (39)21 (41)22 (42)660 (131)660 (131)604 (136)SOA26 (23)10 (30)4 (20)608 (106)608 (106)537 (145)SOA32 (15)10 (29)5 (23)579 (111)579 (111)578 (130)SOA44 (19)4 (19)6 (24)555 (75)555 (75)501 (100)*HoodCongruent*SOA114 (34)17 (38)15 (36)655 (134)655 (134)600 (119)SOA25 (21)10 (30)5 (23)575 (110)575 (110)534 (129)SOA34 (19)10that observing an action activates articulatory plans congruent with the observed action in a somatotopic fashion, based on the results of studies mostly using stop consonants. Past work has so far not demonstrated that vowel stimuli are processed in a similar somatotopic manner (Grabski et al., [@CR15]). The lack of evidence of somatotopic processing for vowels in combination with our reported smaller covert activation effects imply that the type of articulatory plan activated during perception differs for different classes of speech sounds.

Electronic supplementary material
=================================

 {#Sec8}

ESM 1(DOCX 16.6 kb)

This work was supported by the BIAL Foundation under Grant No. 267/14 to P.A. We thank Dan Kennedy-Higgins and Flavia Bojescu for assistance in data collection.


250mm x 150mm Port Pot

Details:

Port Pots are Australian made and of the highest quality. They simple last a life time. Designed with orchids in mind, they also make a perfect pot for all your growing needs. This is the second largest of the port pot range. One of the deepest squats.         available to pods when multiple networks are enabled.
              type: array
              items:
                description: AdditionalNetworkDefinition configures an extra network
                  that is available but not created by default. Instead, pods must
                  request them by name. type must be specified, along with exactly


      description: ClusterNetworkEntry is a subnet from which to allocate
                  PodIPs. A network of size HostPrefix (in CIDR notation) will be
                  allocated when nodes join the cluster. Not all network providers
                  support multiple ClusterNetworks
                type: object
                properties:
     kube-proxy
                should be deployed by the operator. Some network providers include
                kube-proxy or similar functionality. If unset, the plugin will attempt
                to select the correct value, which is false when OpenShift SDN and
                ovn-kubernetes are used and true otherwise.
              type: boolean
            disableMultiNetwork:


   int linecount = 0;
    while(index < text.length()) {
        index += paint.breakText(text,index,text.length,true,maxWidth,null);
        linecount++;
    }

    Rect bounds = new Rect();
    paint.getTextBounds("Yy", 0, 2, bounds);
    // obtain space between lines
    double lineSpacing = Math.max(0,((lineCount - 1) * bounds.height()*0.25));

    return (int)Math.floor(lineSpacing + lineCount * bounds.height());

Note: maxWidth variable is in pixels
Then you will have to call this method inside a while to determine what is the max font size for that height. An example code would be:
textSize = 100;
int maxHeight = 50;
while(getHeightOfMultiLineText(text,textSize,maxWidth) > maxHeight)
  textSize--;

Unfortunately this was the only (as far as I know)   design
 * @package     default_default
 * @copyright   Copyright (c) 2006-2015 X.commerce, Inc. (http://www.magento.com)
 * @license     http://opensource.org/licenses/afl-3.0.php  Academic Free License (AFL 3.0)
 */
.col2-set,
.col3-set,
.col4-set,
.col2-alt-set,
.head,
.page-head,
.page-head-alt,
.header-top-container,
.header-top,
.header-nav-container,
.header-nav,
.quick-access,
#nav,
#nav li,
#nav a,
.middle,
.product-essential,
.button-set,
.actions,
.form-list li,
.button-container,
.ratings,
.page-head,
.page-head-alt,
.group-select li,
.search-autocomplete li,
.side-col li,
.account-box li,
.address-list li,
.listing-type-list .listing-item,
.listing-type-list .product-info .product-reviews,
.account-nav a,
.account-box,
.my-review-detail,
.generic-product-list li { zoom:1; }

.clear { display:block; clear:both; height:0; font-size:0; line-height:0; overflow:hidden; }

input.radio,
input.checkbox { width:13px; height:13px; }
.multi-address-checkout-box .box { zoom:1; }
.multi-address-checkout-box .legend { zoom:1; position:relative; margin-left:8px;}
.quick-access li { padding-right:4px; padding-left:6px;}
.search-autocomplete { left:39px !important; }
.mini-search  { padding-top:-1px; line-height:1em;}
.home-spot { display:inline; }
.mini-related-items .product-details { margin-left:76px; }
.mini-related-items .product-images input { float:left; margin:-4px 2px 0 -4px; }
.mini-related-items .product-images img { float:left; }
#nav ul li.parent { margin-bottom:-3px;}


surface intensely labelled, indicating also the surface localization of the protein. Incubation of the parasites in the presence of a sub-agglutinating concentration of the anti-cysteine proteinase antibody led to a marked increase in their uptake by macrophages. In contrast, addition of the F(ab')2 portion of the same antibody significantly reduced the uptake of the parasites by the macrophages. The results obtained strongly suggest an important participation of cysteine proteinase in the process of T. cruzi-macrophage interaction.tunnels" simply means "above the crazy frigid temperatures of space" not above the freezing point of water.)
The best part? Even a rather ordinary sized comet of 10 km in diameter contains approximately 1 trillion metric tons of usable water for air, fuel, and drinking. That's enough to last a population of a few thousand several generations as an orbital igloo. Obviously all of the actual functioning parts are not ice, but once you attach an engine, reactor, and habitat module to it and fill it with room I am going to say that the comet now qualifies as a spaceship made of ice.
Gravity
Over time the tribe carves the comet into a cylindrical shape which they can rotate to simulate gravity. In the meantime they have sections built within


institutional racism at the time of Stephen's death."

The issue of institutional racism has been a continually difficult one for Scotland Yard's top tier. At the Macpherson inquiry, Lord Condon, then Met commissioner, was visibly discomforted when Richard Stone, one of Macpherson's advisers, repeatedly pressured him to accept that his force was institutionally racist. Stephenson refused to do so, saying the tag would unfairly brand individual officers.

In the years since, the Met has increased minority recruitment from 2.3% of the force in 1993 to 10.4%. But the minority population of the capital is more than 40%.

Black and Asian officers say race relations within the Met have continued to falter since Lord Macpherson's inquiry into the death of Stephen Lawrence. Photograph: PA

In January, the commissioner ordered a radical review ofbeen working ever since. Considering going
back to school for Phd to continue my work on SDN but reading and seeing all
the fuss about ML i am having a rethink abt the SDN and what the future might
hold

~~~
ColinWright
Changing topic area for a PhD is hard work, but usually of significant value,
because you have insights into each from the other. As such, the work provides
a return. But it's hard work.

Will the PhD be of net positive value? In some fields, to have a PhD is of net
_negative_ value (although perhaps only initially) because potential employers
will believe you have only book-learning experience, and are of no practical
use.

Do you _want_ to do a PhD? Why? It's hard work, extremely frustrating, and
usually somewhat marginal. If you work on truly mainstream material there is
always


env.state, use_saved_states=True, save_states=False)
    # Now we reset it, so we should get the same result as initially.
    prob5, value5 = ppo.predict(
        env.state, use_saved_states=False, save_states=True)
    assert np.array_equal(prob1, prob2)
    assert np.array_equal(prob1, prob5)
    assert np.array_equal(prob3, prob4)
    assert not np.array_equal(prob2, prob3)

  @pytest.mark.slow
  def test_hindsight(self):
    """Test Hindsight Experience Replay."""

    # The environment is a plane in which the agent moves by steps until it reaches a randomly
    # positioned goal.  No reward is given until it reaches the goal.  That makes it very hard
    # to learn by standard methods, since it1628). Assigned and self-reported classifications were the same in 86.5 percent of the cases. Information from child health services about mothers who had agreed to participate in the study revealed health-related differences between those who returned the questionnaires and those who did not. The family name classification method indicated an ethnic selectivity in drop-out rates, which was helpful in interpreting these health differences.


procedure was used to control the false discovery rate (FDR). The concordance score between the two lists of DM CpG sites and its statistical significance were calculated by the same method as described above. We defined the DM CpG sites that were consistently detected from the two independent datasets as the population-level DM CpG sites for each cancer.

DNA methylation and gene expression profiling {#Sec9}
---------------------------------------------

Eight paired samples of lung adenocarcinoma tissues and adjacent normal tissues were used for DNA methylation and gene expression detection. Fresh frozen cancer tissue samples were obtained from surgically removed lung specimens. Tumor samples were macro dissected to ensure the purity of the tumor. From the same patient, adjacent normal tissue samples were collected from resected, located approximately 3.5--5 cm away from the tumor site. Alland 49% of the 82 cancer samples (Table [3](#Tab3){ref-type="table"}). Thus, at least three genes, SPARCL1, ENG and TAL1, might be frequently and strongly silenced by the frequently hypermethylated CpG sites within their promoter regions. To further validate the results for these three genes, we measured gene expression profiles for eight paired cancer-normal lung tissues using microarray. The gene expression levels of SPARCL1 and TAL1 were down-regulated in all the eight cancer tissues compared with their paired adjacent normal tissues, while ENG was down-regulated in six of the eight cancer tissues (Table [3](#Tab3){ref-type="table"}).Table 3Down-deregulation frequencies of the five genes regulated by the five frequently hypermethylated CpG sitesCpG siteGene symbleFrequency^1^ (%)Frequency^2^ (%)cg05050341ENG93.9075.00cg12111714ATP8A264.6362.50cg19466563SPARCL198.78100cg19797376TAL189.02100cg26521404HOXA948.7850.00For a gene corresponding to a CpG site, Frequency^1^ and Frequency^2^ represent the down-regulation frequencies of the gene in the 82 publicly


application of the individual-level pathway analysis to 539 samples of lung adenocarcinoma revealed that the neuroactive ligand-receptor interaction pathway, known to be involved in cancer development \[[@CR30], [@CR31]\], was significant in 96.48% of the 539 samples, while the calcium signaling pathway, also known to be involved in cancer \[[@CR32]--[@CR34]\], was significant in 88.87% of the 539 samples (FDR \< 0.05, Additional file [7](#MOESM7){ref-type="media"}: Figure S1). Therefore, these pathways significantly enriched with DM genes in almost all adenocarcinoma tissues deserve our future investigation.

Notably, the majority of the DNA methylation aberrations are not universally appearing in patients of lung adenocarcinoma. For example, 83.64% of the CpG sites with DNA methylation aberrations appeared in less than 80% of all the 539 lung adenocarcinoma tissues from TCGA, reflecting the heterogeneity nature of lung adenocarcinoma. Illumina Human Methylation 450 Beadchip

KEGG

:   Kyoto Encyclopedia of Genes and Genomes

FDR

:   false discovery rate

Haidan Yan and Qingzhou Guan contributed equally as first authors

ZG, FH and HDY conceived and designed the overall study. QZG participated in study design and revised the manuscript. HDY, JH and YQL performed the computational experiments. JZ, HDL, HPL, and YYG participated in study design. HDY, YYG and ZG wrote the manuscript. All authors read and approved the final manuscript.

Acknowledgements {#FPar1}
================

Not applicable.

Competing interests {#FPar2}
===================

The authors declare that they have no competing interests.

Availability of data and materials {#FPar3}
==================================

DNA methylation and gene expression profiles of eight paired samples of lung adenocarcinoma tissues and adjacent normal tissues are available at the Gene Expression Omnibus database (<http://www.ncbi.nlm.nih.gov/geo/>) under Accession Numbers GSE85845 and GSE85841.

Consent for


Q:

Infinite loop in a JPanel

I want to program a simple Snake.
Therefore I have programmed a custom JPanel, which can hold a Scene.
A Scene just draws something, and you can thread it with the public void run() method, so it implements Runnable.
Now, when I initialise the Scene, I create a Thread of the instance.
if (this.getThread() == null) {
    Thread sceneThread = new Thread(this);
    this.setThread(sceneThread);
    this.getThread().run();
} else {
    System.err.println("Scene is already running");
}

And the scene finally begins to be executed in a separate thread:
// Run thread
public void run () {
    try {
        while (true) {
            this.update();
  off the outside of the rig, he got into his car and drove back to the scene. This time he noticed the quiet road, the .2 moon, the farmhouse just beyond the place where the Caddy had rolled. A tow truck was pulling onto the road. Nye put out a flare he'd lit behind the tow truck. "Why are you back?" the cop asked.

Never a _How's she doing?_ with the Weasel.

"I tossed her keys onto the grass," Webster said.

"If it was her car keys, don't bother looking."

"No, it was something else."

"She oughta go to jail. She could have killed someone. Herself even."

"Then jail wouldn't do her much good, would it?" Webster said as he began to search the depressed grass where the car had come to rest. As


he had produced the most beautiful baby he'd ever seen. His mother took up her knitting needles, and it seemed that every time she came to the apartment, she had knit another item for Rowan: baby clothes and blankets when Rowan was a newborn; stuffed toys and sweaters and a beautiful green and blue coat for when she could sit up. Burrows and his wife gave Sheila and Webster a snazzy stroller that came apart and seemed to be able to do everything except cook dinner.

With Rowan in his arms, Webster rubbed noses with her and told her she was a pain in the ass. He walked her all over the apartment showing her the lights. He did and redid the same five-piece puzzle with her a hundredare harmed and the monarch butterfly has declined by 90% with studies laying the blame on GM farming.

We hear a lot about the potential for GM to solve global problems but you can’t fix the system one gene at a time. Resilience in an uncertain future relies on diversity, not GM monocultures.

We use cookies to ensure that we give you the best experience on our website and to help us monitor the effectiveness of our campaigns. This includes targeting cookies that may be used by Facebook or Google to show you adverts (on other websites) that they believe you will be interested in. If you continue to use this site we will assume that you are happy with it.Ok


advertisements on Amazon. It states that the Battlefield V currency can be purchased and redeemed in various volumes starting January 18th, even though an official confirmation is still pending. Before that, however, it was emphasized that the fiasco like in Star Wars: Battlefront II should be avoided this time. Therefore the premium currency can only be used for cosmetic things like skins

3D accelerators, online gaming, free-2-play, virtual reality, loot boxes: Hardly any other industry is subject to new trends as often as the video game industry. But what will be the next big thing? Many people are betting on the Blockchain - and for good reasons.Q:

How do I replace multiple words within each row of a column that contains full sentences?

I have a data frame (let's call it 'littletext') that has a column with sentences within each row. I also have another table (let's call it 'littledict') that I would like to use as a reference by which to find and replace words and/or phrases within each row of 'littletext'.
Here are my two data frames. I am hard-coding them in this example but will load them as csv files in "real life":
raw_text = {
    "text": ["Hello, world!", "Hello, how are you?", "This world is funny!"],
    "col2": [0,1,1]}

littletext = pd.DataFrame(raw_text, index = pd.Index(['A', 'B', 'C'], name='letter'), columns = pd.Index(['text', 'col2'], name='attributes'))

raw_dict = {
    "key": ["Hello",


Charcoal portrait of Bill Anderson in jacket with top button closed, shirt, carvat, and a brimmed hat with a lone star on the upturned brim and embellished with an ostrich plume. The drawing is signed by the artist with "93" immediately below the signature. At the bottom right corner, "Wm. Anderson" is written in different handwriting and black ink.

Biographical Note

Bill Anderson was a chief lieutenant under William C. Quantrill and earned the sobriquet "Bloody Bill." He later was a lieutenant under George Todd. He was part of the Lawrence massacre on August 21, 1863, and responsible for much of the Centralia, Missouri, massacre on September 27, 1864. He was killed October 26, 1864, near Orrick (Ray County), Missouri.

The portrait was separated from the original mat board. It isbelieved that most of the Stewart drawings were made from photographs. The MVO (Missouri Valley Oversize) is composed of various types of art work including paintings, sculpture, drawings and sketches, large-size photographs, posters, and other miscellaneous items.

Reproduction (printing, downloading, or copying) of images from Kansas City Public Library requires permission and payment for the following uses, whether digital or print: publication; reproduction of multiple copies; personal, non-educational purposes; and advertising or commercial purposes. Please order prints or digital files and pay use fees through this website. All images must be properly credited to: "Missouri Valley Special Collections, Kansas City Public Library, Kansas City, Missouri." Images and texts may be reproduced without prior permission only for purposes of temporary, private study, scholarship, or research. Those using these images and