can be construed as evidence for local production of cellular renin, as an uptake mechanism from the blood compartment cannot be excluded.

Many cell types in myocardial tissue, including cardiomyocytes, contain receptors for Ang II, but as indicated above the activation of these receptors requires angiotensin concentrations in the micromolar range, which do not occur in plasma in vivo. However, angiotensins formed locally in the heart can activate these receptors in a paracrine and autocrine mode[@CR81]. Indeed, recent studies have provided compelling evidence for the existence of an intracellular RAS that functions as an *autocrine* system[@CR67],[@CR68],[@CR74]--[@CR76],[@CR81]. It has been suggested that intracellular generation of Ang II may occur via a non-renin pathway with rerouting of Aogen to other subcellular structures[@CR67],[@CR68],[@CR71],[@CR74]--[@CR76],[@CR81]--[@CR89]. With this in mind, we began to explore theThe present invention relates to methods for determining the structure of polypeptides having particular structural and biological activities and affinities.
The systematic design of pharmaceutical agents has currently reached a point where medicinal pharmacologists can often predict the activity of a particular pharmacologic agent from knowledge of its structure/function activity on a chemical level. This knowledge has been particularly useful in the design of new pharmacologic agents which are structurally related to a parent compound, but which exhibit new pharmacologic properties or activities.
For example, in the area of steroid biochemistry and design, the structure of various steroids has been modified in numerous ways to provide for enhanced or specialized activities. Another example of systematic drug design is in the medicinal chemistry of the synthetic penicillins: synthetic penicillins have now


which this concept may be envisioned is to consider the model concept of a lock and its key, with the lock configuration representing the amphiphilic structure of the receptor and the configuration of the key representing the complementary amphiphilic structure of the hormone agent.
Accordingly, a means of systematically designing polypeptides which are capable of binding or interacting with known peptides, proteins or proteinaceous receptors would be of great utility. For example, practical knowledge concerning the design of receptor-interactive structures of proteinaceous hormones should lead to the development of whole new classes of synthetic hormones with greater specificity of activity. Conversely, one could design and produce polypeptides which are complementary to known proteinaceous hormones and therefore capable of binding to these hormones. Such designed polypeptides may be utilized, forin Sources */ = {isa = PBXBuildFile; fileRef = 08F592F118E9BBA5006D0BF2 /* AAPLAppDelegate.m */; };
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		08F2F41618FD35640014A20F /*chief justice also took the pen for the majority in that fight, flatly dismissing the idea of courts resolving such disputes.

Hewitt declared the gerrymandering decision to be far more consequential.

“Conservatives coiled to condemn Chief Justice over citizenship question need to focus on this incredibly important, far reaching and absolutely correct decision,” Hewitt tweeted. “Would anyone preferring that #SCOTUS clearly uphold census question and at same time continue the decades of absurd ambiguity about the clearly-delegated-to-political-bodies re-districting power please raise their hands? I know you’d like both, but if you had to choose either?”

There is a degree of selective outrage at Roberts. Trump’s newest nominee to the court, Justice Neil Gorsuch, sided with liberals in a series of 5-4, late-term decisions this year, but they were less high-profile. As


Gorsuch ruled in favor of criminal defendants — including a child pornography convict — in a pair of cases related to sentencing, there was no outcry from the right that Trump’s pick was abandoning his backers.

Still, Roberts’ tendency to side with liberals in some cases embraced by many Republican activists seems to grate on many conservative lawyers, including some who helped lead the fight to confirm him.

“I still haven’t fully psychologically accepted the truth about Roberts,” said Curt Levey of the Committee for Justice in an interview.

“He may in his heart think he’s a conservative, but he’s not going to be what conservatives want and liberals fear. … With each passing year — maybe this doesn’t happen every year, but we’ve seen enough of it, we kind ofincreased to that of a required minimum of 10,000 euros per month. The option that both players finish their playing careers and enter into coaching activities was considered. In mid-September 2010, the search was over for Karamyan brothers. The football players signed a contract with and officially moved into Unirea Urziceni. Near the end of a match, Arman made his debut for the club coming in as a substitute for 81st minute of the game.

In late October 2011, Stoichiță, who knew firsthand the playing abilities of both brothers, invited them to his current team Mioveni. However, Artavazd decided to retire as a player and go into business.

A year later, Artavazd resumed his career and he and Arman both joined the Liga II club CS Buftea. In their first


not be an idiot in the off season. That remains a question obviously.

He already comes from money so I'm not overly worried about newfound wealth suddenly changing him as a person. Right now it has strings attached, and once he doesn't have to live off of daddy's trust fund I could see him flaming out from substance abuse and too much partying.

The only first round guy I'd be okay with Miami taking should he slip would be Derek Carr.

Unfortunately I don't know if Miami has the resources to grab an extra QB this year because of the holes on the o-line, RB, TE and DT.

I love having Matt Moore as a quality backup, but I wouldn't be surprised if they traded him to fill some holes and draftedRobert MacLean believed that a 2003 TSA plan to dramatically scale back the deployment of air marshals — even in the face of credible terror plots — due to fiscal concerns would post a serious security threat. The ruling is a historic victory for the right of individuals to make a difference through freedom of speech.” In 2003, MacLean received an alarming emergency alert from the Department of Homeland Security, detailing a “specific and imminent terrorist threat focused on long-distance flights – a more ambitious, broader-scale version of the 9/11 plot,” court briefs say.

Lawyers for the government stated in court that MacLean violated internal TSA regulations against public disclosure of “aviation security measures,” the Los Angeles Times reported. MacLean, received a secret briefing from the T.S.A. about a


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No temptation has overtaken you except what is common to mankind. And God is faithful; he will not let you be tempted beyond what you can bear. But when you are tempted, he will also provide a way out so that you can endure it. - 1 Corinthians 10:13 (NIV)

We are all one poor choice from being a subject on this forum. Think twice.set of 799 casting GM heads were bolted on to the engine next. Finally, a Holley High Ram lower intake was selected to be used with a fabricated aluminum upper intake to assist with transferring boost into the engine.

The Mustang received a lot of chassis work at Dow Brothers Racecars to help make the LS engine fit and add a custom roll bar to the car. Dow Brothers also modified an AJE Colt 65 kit to make room for the turbo kit they fabricated. In the rear a custom four-link suspension was built, and has been supplemented with a wishbone that keeps the 8.8-inch rearend from a late model Cobra Mustang in place. An extra beefy anti-roll bar rounds out the rear suspension along with a set of


A blog on the current crises in the Middle East and news accounts unpublished by the US press. Daily timeline of events in Iraq as collected from stories and dispatches in the French and Italian media: Le Monde (Paris), Il Corriere della Sera (Milan), La Repubblica (Rome), L'Orient-Le Jour (Beirut) and occasionally from El Mundo (Madrid).

Wednesday, August 10, 2005

Iran's Nuclear Ambition

If I appear to be an over-the-top fangirl of France, it is because they are capable of communicating with the public on the terms of an informed adult. I can't bear US punditry and Main Street editorials, which cater to children.

At first glance, negotiations between the international community and Iran on the nuclear question seem complex, with endless reversals, pressures, blackmail and avowals of sincerity. In reality, the
The Legend of Prince’s Special Custom-Font Symbol Floppy Disks - tintinnabula
http://nymag.com/selectall/2016/04/princes-legendary-floppy-disk-symbol-font.html
======
cs702
For those who don't know, Prince legally changed his name to a made-up
unpronounceable symbol in the early 90's to sidestep restrictions in the
contract he had signed with his record company, Warner, which at the time had
the rights to use the name "Prince" for music and merchandise.

After the legal name change, news outlets started calling him "the artist
formerly known as Prince." Meanwhile, Warner had no rights to the new,
unpronounceable name. Warner executives likely were not too happy about that,
but couldn't do anything about it.

In 2000, after the contract with Warner expired, Prince went back to using his
old name.

Source:
[http://www.bbc.com/news/magazine-36107590](http://www.bbc.com/news/magazine-36107590)

~~~
svantana
Is the part about him _legally_ changing his name really true? All the sources
say so, but surely there are laws and regulations


around name changes in the
US. I have a hard time imagining the IRS having him down as the symbol.

Also, changing your name can't be a legal way of getting out of contracts, can
it? If it is, then someone should let Ke$ha know...

~~~
toast0
Looking at the discography and discussion on the Wikipedia artivle, I don't
think the name change got him out of his contract. It seems that he had to
release a certain number of albums to finish his contract. I think by using
the symbol on those albums, he prevented Warner brothers from having rights to
use his name in connection with it. He probably negotiated his next contract a
bit differently.

~~~
bitwize
What he did was start turning the crank, churning out five albums in three
years, since the contract stipulates a certain number ofalbums to be
produced. Which leads one to wonder if he didn't want the Prince "branding"
applied to this work; maybe he thought the label was meddling too much and it
wasn't really his work?

------
CapitalistCartr
He also performed with "Slave" painted across his face/chest. He _REALLY_
didn't like his treatment by the studio.

------
galago
Ha! You type "P" for the symbol-- so he doesn't have his own Unicode
codepoint?

The font may have an ambiguous license, but it appears that it was _meant_ to
be widely distributed to promote Prince. Is it available anywhere? I could
make my own, but that wouldn't be the same.

~~~
GauntletWizard
No, he doesn't, and it's a crying shame. Contact your local Unicode consortium
representative - If and 𒀽 deserve Unicode codepoints, the artist formerly
known as Prince surely does too.

~~~
jloughry
To propose this character to the UTC (Unicode


color: "#0073b7"
        }, {
            label: "Series4",
            data: 50,
            color: "#00c0ef"
        }];
        $.plot("#donut-chart", donutData, {
            series: {
                pie: {
                    show: true,
      });
        /*
         * END DONUT CHART
         */

    });

    /*
     * Custom Label formatter
     * ----------------------
     */
    function labelFormatter(label, series) {
        return "
" + label + "
" + Math.round(series.percent) + "%
";
    }
    </script>


  btnIniciar=(Button)findViewById(R.id.btnIniciar);

        btnIniciar.setOnClickListener(new View.OnClickListener() {
            @Override

        });

    }
}

A:

Primeramente necesitas definir el método onClick() del listener y dentro agregas el código necesario para el envío del texto contenido dentro del EditText (por cierto no defines cual EditText) , como ejemplo el EditText txtNombre:
 btnIniciar=(Button)findViewById(R.id.btnIniciar);

        btnIniciar.setOnClickListener(new View.OnClickListener() {

            public void onClick(View v) {
               enviarEmail(txtNombre.getText().toString());
            }

  funnel." "Rainbow Dash, you'n'Fluttershy stay on top of 'em; don't let 'em fly away." "Rainbow Dash:" "Aye, aye!" "Applejack:" "YEEE-HAW!" "Applejack:" "All right, y'all, here goes nothin'!" "Look out, Rarity!" "That one's fixin' to get away!" "(country music)" "Keep a lean on 'em, Rainbow Dash!" "(country music)" "(country music)" "Hold on, girls!" "We're almost there!" "(country music)" "Twilight:" "Pinkie!" "(country music)" "Pinkie Pie:" "Twilight!" "We don't have much time!" "(country music)" "Twilight:" "You're telling me!" "The princess could arrive at any moment!" "(country music)" "Pinkie Pie:" "Exactly." "That's why I need you girls to drop what you're doing and help me find some maracas!" "(country music)" "Twilight:" "Maracas..?" "Pinkie, we've got much bigger problems than missing maracas!" "(country music)" "Pinkie Pie: (gasps) You're RIGHT!" "(country music)" "Getting a


S.Ct. 391, 19 L.Ed.2d 444 (1967), sanctions the application of the abstention doctrine in "narrowly limited `special circumstances.'" Justice Brennan, in his concurring opinion in Kaiser Steel Corp. v. W. S. Ranch Co., 391 U.S. 593, 594-595, 88 S.Ct. 1753, 20 L.Ed.2d 835 (1968), wrote that the "special circumstances" which permit abstention exist when the state law issue is of vital concern to the state involved.
"Special circumstances" were found in Reetz v. Bozanich, 397 U.S. 82, 90 S.Ct. 788, 25 L.Ed.2d 68 (1970). In holding that the district court should have abstained from deciding that case on its merits, the Supreme Court in Reetz said: "A state court decision here, however, could conceivably avoid any decision under the Fourteenth Amendment and would avoid any possible irritant in the941, 91 S.Ct. 1612, 29 L.Ed.2d 112 (1971).
Accordingly, it appears to this Court that there are "special circumstances" here which make application of the abstention doctrine appropriate.
The statutes that provide for the convening of three-judge district courts place a heavy burden on the federal court system. In Ex parte Poresky, 290 U.S. 30, 54 S.Ct. 3, 78 L.Ed. 152 (1934), the Supreme Court held that a single judge can dismiss an action brought under § 2281 et seq. for lack of jurisdiction and that jurisdiction is lacking if the federal constitutional claim is insubstantial. Further, in Smith v. State of California, 336 F.2d 530 (9th Cir. 1964), the Court of Appeals for the Ninth Circuit held that the single district judge to whom the case is assigned should


in
these things.

The problem is in people's heads, not the sky.

~~~
dsabanin
I agree, the problem is in the heads of the people who blindly trust
everything they are told. Why is it so outrageous to assume that chemtrails
might be a covert experiment to manipulate climate (or has some other
purpose)? I'm not saying that it is, but is it outrageous to doubt official
narratives? Since when is that scientific?

Doubt is reasonable, there's no problem here. Unquestioned belief in "common
sense" and what authority figures say is not. A lot of people have a lot to
gain by leading the public to believe certain things. Isn't it too naive to
assume that you are always being told the truth, when some stakes are so high?

~~~
alistairSH
_Why is it so outrageous to assume that chemtrails might be a covert
experimentthe authorship of many
books, most of which are not available. Sanmatitarka (‘The Logic of
the True Doctrine’) is the first major Jain work on logic written in
Sanskrit.[2][3]Contents1 Life
2 Thought
3 Works
4 Notes
5 ReferencesLife[edit]
SiddhasenaSiddhasena Divakara is said to have lived from 500 CE to 610 CE. He
was a Brahmin by birth and a scholar. He was initiated by Acharya
Vruddhavadi.[4] According to the tradition,
SiddhasenaSiddhasena Divakara once
planned to translate all the Jaina works from prakrit to Sanskrit
[...More...]

Samantabhadra (Jain Monk)
Samantabhadra was a
DigambaraDigambara acharya (head of the monastic order) who
lived about the later part of the second century CE[1][2] He was a
proponent of the Jaina doctrine of Anekantavada. The Ratnakaranda
śrāvakācāra is the most popular work of Samantabhadra.
Samantabhadra lived after
UmaswamiUmaswami but before Pujyapada.Contents1 Life
2 Thought
3 Works
4 Praise
5 References
6 SourcesLife[edit]
Samantabhadra is said to have lived from 150


CE to 250 CE. He was from
southern India during the time of Chola dynasty. He was a poet,
logician, eulogist and an accomplished linguist.[3] He is credited
with spreading
JainismJainism in southern India.[4]
Samantabhadra, in his early stage of asceticism, was attacked with a
disease known as bhasmaka (the condition of insatiable hunger).[5] As,
digambara monks don't eat more than once in a day, he endured great
pain
[...More...]

HaribhadraHaribhadraHaribhadra Suri was a
SvetambaraSvetambara mendicant Jain leader and author.
There are multiple contradictory dates assigned to his birth.
According to tradition, he lived c. 459–529 CE. However, in 1919, a
Jain monk named Jinavijayi pointed out that given his familiarity with
Dharmakirti, a more likely choice would be sometime after 650.[1] In
his writings,
HaribhadraHaribhadra identifies himself as a student of Jinabhadra
and Jinadatta of the Vidyadhara Kula. There are several, somewhat
contradictory, accounts of hisa distance after definitively locating your prey.

When games like Quicksilva's Mined Out ; Virgin Interactive's Yomp ; and Conway, Hong and Smith's Reletless Logic appeared in the '80s, they looked like Cube on the surface: move from one point to another avoiding randomly placed mines. But in terms of solving, the games played more like Wumpus : move along safe areas, then put all the information to use locating the hidden dangers. Tom Anderson's Mines later added a feature that let you mark suspected mines with flags. And the stage was finally set for the Minesweeper to (ahem) explode onto the scene.

Dropping the Bombshell

The Minesweeper that we all know and love was created by Robert Donner and Curt Johnson while they were working at Microsoft. It was first


be more resistant to such techniques). Using a two-button mouse to quickly reveal and flag squares, the game moves much faster than its predecessors. And in addition, there was a pleasant smiley face at the top of the game.

Like many simple logic games, Minesweeper relies on recognizing common patterns. After getting used to the game, you start to see some of these patterns on your ownm but the more complicated patterns will only be noticed if you're truly dedicated to working out the logic. Many people aren't willing, because many of the randomly generated boards of Minesweeper involve guessing anyway. It's fairly common to discover that, after clearing almost all of the board, there are two cells, each with a fifty-fifty chance of hiding a mine. Of course,    return False
    with pytest.raises(vaex.execution.UserAbort):
        assert df.x.min(progress=progress) is None
    magic.assert_called_once()

@pytest.mark.asyncio
async def test_cancel_async(df):
    magic = MagicMock()
    df.executor.signal_cancel.connect(magic)
    def progress(f):
        return False
    with pytest.raises(vaex.execution.UserAbort):
        value = df.x.min(progress=progress, delay=True)
        await df.execute_async()
        await value
    magic.assert_called_once()

# @pytest.mark.timeout(1)
def test_cancel_huge(client):
    df = client['huge']
    import threading
    main_thread = threading.current_thread()
    def progress(f):
        assert threading.current_thread() == main_thread


likely due to inadequate perfusion during cardiopulmonary bypass, and lactate washout after adequate perfusion has been established. The return to aerobic metabolism with clearance of lactate demonstrates that the AbioCor is able to provide complete circulatory support with normal tissue perfusion.Languages

Nigeria: Delay in trial of Amina Lawal

Source:

BBC

An appeal, due to begin in northern Nigeria for Amina Lawal, a Muslim woman convicted of adultery and sentenced to death by stoning, has been postponed because the judges failed to turn up.

The BBC reports that Amina's appeal has now been delayed until after next month's elections. Although no reason was given for the failure of the judges to turn up, the clear inference being made is that the decision was political. That is because the holding of such a case during election campaigning could have inflamed tensions, never far from the surface, between Muslims and Christians.


B10 fibril specific antibody fragment \[[@pone.0232266.ref053]\]. In the top hundred docked complexes, cSNK interacts predominantly to the framework of B10, and only rarely close to the CDRs of B10.

Interaction between Fv5E3 and A*β* oligomers {#sec005}
--------------------------------------------

In the following sections, we go through the models of A*β*Os proposed in the literature and classify them into Fv5E3-positives and possibly Fv5E3-negatives. This classification was performed based on the combination of docking and MD simulation results. We believe Fv5E3-positive A*β* aggregates should have structural characteristics similar to cSNK that is a sharp turn at the epitope residues G25-G29, a solvent exposed K28, and available space around a few of the turns to enter the binding pocket of Fv5E3. In the following sections, we also reveal the molecular details of the interactions between Fv5E3and the cognate A*β*Os for which structures are either resolved experimentally or predicted computationally.

### Experimental models of A*β* oligomers {#sec006}

A*β*Os are transient entities; this has made it difficult to determine their molecular structures. To overcome the transient nature of A*β*Os, various modifications have been performed on the sequence of A*β* to generate stabilized oligomers. It is hard to judge whether these modified constructs represent well the structure of the physiologically relevant A*β*Os. Below, we analyze how these proposed experimental models of A*β*Os interact with Fv5E3.

### The trimer model of A*β*17-36 oligomers by Kreutzer et al {#sec007}

The crystal structure of a trimer from a cyclized A*β*17-36 was determined by Kreutzer et al. \[[@pone.0232266.ref033]\] (pdb entry 5hoy, Panel A of [S1 Fig](#pone.0232266.s001){ref-type="supplementary-material"} of SI). Higher order oligomers were observed to


oligomer. As the LRMSDs do not converge, it is not possible to properly estimate the binding affinity between the oligomer and Fv5E3.

### Computational and theoretical models of A*β* oligomers {#sec010}

In addition to the experimental models considered in the previous sections, some of the structural models of the oligomers have been built computationally based on available experimental constraints, and the rest of the proposed models are purely theoretical and do not rely on any experimental data. The computational and theoretical models may not be as accurate as the experimentally resolved models presented in the previous section. However, the analyses of their interactions with Fv5E3 allow us to propose experiments with oligomers that have similar structures. In the following sections, we will assess Fv5E3's ability to bind to these computationalinteract with Fv5E3 than the study of a single one. Here, we choose one of these models as a representative of the *β*-barrel models.

In this hexameric *β*-barrel model, each A*β* monomer is made of three antiparallel *β*-strands. Parallel *β*-strands of adjacent A*β* peptides align with each other around the model (Panel D of [S1 Fig](#pone.0232266.s001){ref-type="supplementary-material"} of SI). K28s are solvent-exposed in this model, and in six other *β*-barrel models proposed by Shafrir et al. In three of the models, the K28s' side chains are located on the surface, but they do not stick out to the solvent, and are stabilized by interactions with other residues. In one of the eleven *β*-barrel models; however, K28s of three chains are completely buried inside the turns.

For the selected *β*-barrel model, sharp


et al. \[[@pone.0232266.ref034]\], with a wide solvent-accessible turn at G25-G29. The distance between G25 and G29 of individual A*β* peptides in this model is 11.51 Å. The dodecamer model by Gallion assumes that the K28 residue is buried inside, as it was shown to be buried inside the globulomers \[[@pone.0232266.ref019]\]. In the Gallion's model, the K28 side chain interacts with the mainchain carbonyls of A21 and D23, and not the side chain of D23. The K28 residue is still partly solvent-exposed in some chains of the Gallion's model.

The N-termini residues (1-16) of the model obstruct the access of Fv5E3 to the G25-G29 turn. If the N-termini residues were rigid and had little flexibility, then Fv5E3 would not be able to detect these types of oligomers specifically through itsm5E3-specific epitope can also be sequestered among cross-*β* sub-units. This provides a second barrier for m5E3 binding to fibrils specifically through its epitope. To verify these claims computationally, we perform detailed analyses of the interactions between available structural models of the A*β* fibrils and the Fv model of the m5E3 antibody.

### The model of A*β*40 fibrils by Lu et al {#sec015}

Lu et al. resolved with nuclear magnetic resonance (NMR) experiments a quaternary molecular structure for the A*β*40 fibrils seeded with the brain-derived A*β* fibrils \[[@pone.0232266.ref027]\] (pdb entry 2m4j, Panel A of [S2 Fig](#pone.0232266.s002){ref-type="supplementary-material"} of SI). The deposited structure of the protofilament has three layers (4.8 Å apart from each other) perpendicular to the axis of the fibril. Each layer has a three-fold symmetry of the A*β*40 peptide.

In our


sequence, and hence the interactions with these two residues may not be present in vitro. From the epitope residues, only S26 and N27 form hydrogen bonds (with low occupancies) ([S8 Table](#pone.0232266.s020){ref-type="supplementary-material"} of SI). The residue E11 of chain E of the fibril, and K59 of the heavy chain form a high occupancy ionic interaction. R66 also forms a salt bridge with E22 of the fibril ([S9 Table](#pone.0232266.s021){ref-type="supplementary-material"} of SI). The R50 of Fv5E3's heavy chain and Y91 of the light chain participate in high occupancy cation-*π* interactions with Y10 and K16 of the fibril, respectively ([S9 Table](#pone.0232266.s021){ref-type="supplementary-material"} of SI). R50, K59 and R66 interact with the fibril, but do not interact with the A*β*Os. Site-directed mutagenesis of these residues to acidic residues or glycine residues may provide anthis complex can fragment this protofilament. The perturbations seen in the LRMSD of the complex is due to the perturbations in the protofilament model, the corresponding adjustments in the antibody, and changes in their orientations with respect to each other (Panel F of [Fig 7](#pone.0232266.g007){ref-type="fig"}). The LRMSD of the complex does not converge during the course of the simulation (Panel F of [Fig 7](#pone.0232266.g007){ref-type="fig"} in red).

An ionic interaction between K28 of chain B of Xiao's model and E102 of the heavy chain of Fv5E3 exists with high occupancy ([S11 Table](#pone.0232266.s023){ref-type="supplementary-material"} of SI). Hydrogen bond and cation-*π* interaction between K28 of chain B of Xiao's model, and Y27 of the heavy chain of Fv5E3 also exist with not high occupancy ([S10](#pone.0232266.s022){ref-type="supplementary-material"} and [S11](#pone.0232266.s023){ref-type="supplementary-material"} Tables of SI). The S26 epitope


residue also participates in formation of hydrogen bonds with Fv5E3. However, the occupancies of its hydrogen bonds are low ([S10 Table](#pone.0232266.s022){ref-type="supplementary-material"} of SI). The hydrophobic interactions have very low occupancies as well. There are no aromatic-aromatic or aromatic-sulphur interactions between the cross-*β* sub-unit and the Fv model of the antibody after the 100-*ns* simulation. As the simulation does not converge (Panel F of [Fig 7](#pone.0232266.g007){ref-type="fig"} in red), it is not possible to measure the binding affinity of the Fv5E3 and the cross-*β* sub-unit properly. It would be interesting to apply our approach to the model of antibodies specific to these protofilaments to see if they have the same effect of fragmenting them.

As the occupancy of most interactions between Fv5E3 and Xiao's cross-*β* sub-units are low, we do notlength, and the results of our docking simulations showing that Fv5E3 can only bind to the end of these fibrils (Panels A, D and G of [Fig 6](#pone.0232266.g006){ref-type="fig"}) explain why m5E3 has a low affinity for fibrils. As Fv5E3 binds specifically to the end of fibrils, not to their extended solvent exposed hydrophobic surfaces, its binding cannot be considered as an entropy-driven process at physiological temperatures \[[@pone.0232266.ref074]\]. The Fv5E3 antibody may not be able to bind to the synthetic A*β*42 fibrils described in Refs. \[[@pone.0232266.ref041]\] and \[[@pone.0232266.ref030]\] with high affinity as the occupancies of the interactions between their corresponding cross-*β* sub-units proposed by Xiao et al. \[[@pone.0232266.ref040]\] and Fv5E3 are low. Based on our results, we believe that the Lührs' model of the A*β*42 cross-*β* sub-unit \[[@pone.0232266.ref039]\] may


two CDRs were assumed to have the largest of deviations from their native conformations. Disulfide bonds were formed between the cysteine residues with no additional repacking (*find_disulf* and *norepack_disulf*). Multiple computer processes were used to perform the dockings (*multiple_processes_writing_to_one_directory*).

The Rosetta command used in docking simulations was *mpiexec -n 128 rosetta.gcc aa M5E3 \_ -dock -dock_mcm -quiet -nstruct 2000 -fake_native -fab1 -pose -ensemble1 1 -dock_pert 3 8 8 -spin -ex1 -ex2aro_only -unboundrot -s M5E3 -dock_rtmin -find_disulf -norepack_disulf -use_pdb_numbering -fake_native -skip_missing_residues -pose -snugdock -snugloop -snugh3 -snugh2 -multiple_processes_writing_to_one_directory*.

The Rosetta score approximates the free energy of the complex. It is calculated based on a combination of physical (e.g., electrostatics), empirical (e.g. hydrogen bonds) and statistical (e.g., probability of finding the torsion angles in Ramachandran space) terms \[[@pone.0232266.ref081]\]. A lower score indicates ain hydrophobic, ionic and aromatic-aromatic interactions between Fv5E3 and the models of A*β* fibrils.

(PDF)

######

Click here for additional data file.

###### The residues forming hydrogen bonds between Fv5E3 and the cross-*β* sub-units of A*β* fibrils.

(PDF)

######

Click here for additional data file.

###### The residues participating in hydrophobic, ionic, and aromatic-aromatic interactions between Fv5E3 and the cross-*β* sub-units of A*β* fibrils.

(PDF)

######

Click here for additional data file.

We greatly appreciate the authors of models of A*β*Os for providing their coordinate files. We also thank WestGrid for providing computing resources.

[^1]: **Competing Interests:**The authors have declared that no competing interests exist.

[^2]: Current address: Center for Brain Health, Vancouver, BC, Canada


int count_put_receive_buffer;
	unsigned int count_reassembly_queue;
	unsigned int count_enqueue_reassembly_queue;
	unsigned int count_dequeue_reassembly_queue;
	unsigned int count_send_empty;
};

enum smbd_message_type {
	SMBD_NEGOTIATE_RESP,
	SMBD_TRANSFER_DATA,
};

#define SMB_DIRECT_RESPONSE_REQUESTED 0x0001

/* SMBD negotiation request packet [MS-SMBD] 2.2.1 */
struct smbd_negotiate_req {
	__le16 min_version;
	__le16 max_version;
	__le16 reserved;
	__le16 credits_requested;
	__le32 preferred_send_size;
	__le32 max_receive_size;
	__le32 max_fragmented_size;
} __packed;

/* SMBD negotiation response packet [MS-SMBD] 2.2.2 */
struct smbd_negotiate_resp {
	__le16 min_version;
	__le16 max_version;
	__le16 negotiated_version;
	__le16 reserved;
	__le16 credits_requested;
	__le16 credits_granted;
	__le32 status;
	__le32 max_readwrite_size;
	__le32 preferred_send_size;
	__le32 max_receive_size;
	__le32 max_fragmented_size;
} __packed;

/* SMBD data transfer packet with payload [MS-SMBD] 2.2.3 */
struct smbd_data_transfer {
	__le16 credits_requested;
	__le16 credits_granted;
	__le16 flags;
	__le16 reserved;
	__le32 remaining_data_length;
	__le32 data_offset;
	__le32 data_length;
	__le32 padding;
	__u8 buffer[];
} __packed;

/* The packet fields for a registered RDMA buffer */
struct smbd_buffer_descriptor_v1 {
	__le64 offset;
	__le32 token;
	__le32 length;
} __packed;

/* Default maximum number of SGEs in a RDMA send/recv */
#define SMBDIRECT_MAX_SGE	16
/* The context for a SMBD request */
struct smbd_request {
	struct smbd_connection *info;
	struct ib_cqe cqe;

	/* the SGE entries for this packet */
	struct ib_sge sge[SMBDIRECT_MAX_SGE];
	int num_sge;

	/* SMBD packet header follows this structurestruct page *pages[], int num_pages,
	int offset, int tailsz, bool writing, bool need_invalidate);
int smbd_deregister_mr(struct smbd_mr *mr);

#else
#define cifs_rdma_enabled(server)	0
struct smbd_connection {};
static inline void *smbd_get_connection(
	struct TCP_Server_Info *server, struct sockaddr *dstaddr) {return NULL;}
static inline int smbd_reconnect(struct TCP_Server_Info *server) {return -1; }
static inline void smbd_destroy(struct TCP_Server_Info *server) {}
static inline int smbd_recv(struct smbd_connection *info, struct msghdr *msg) {return -1; }
static inline int smbd_send(struct TCP_Server_Info *server, int num_rqst, struct smb_rqst *rqst) {return -1; }
#endif

#endif


who still persecuted him without ceasing and would not let him get home.

Bailey Bow Ugg Boots Classic Mini Fox Fur 5854 Ugg Boots - Black

” But Holmes contended that it made him more confident: “After he did it, he was in a different place. Gucci Luggage Set Jobs and Wozniak took a TWA flight to Philadelphia, cradling one cigar box with the Apple I and another with the prototype for the successor that Woz was working on.Ugg Australia Boots For Cheap I grew up in a middle-class family, so I never thought I would starve. The Classic Mini Leather is a fall-perfect bootie boasting all the beloved characteristics of the Classic Collection, keeping feet dry and comfortable with a moisture-wicking natural wool lining and trademark molded-EVA outsole. Boastingaccomplish. He's very wise about running and training, and a talented coach.

Joe is a man of the world. British? French? American? Not sure if those are the best terms to describe Joe. I'd likely go with runner, adventurer, artist, liver of life to the fullest, and stuff along those lines. :-)

As far as I know, our 'general use' internet stations (not many of them), for the staff (not the bosses nor the SysAdmins) ONLY have the basic ports open for http/s, like 80, 443 and ftp which I think is 20. I 'KNOW' that I can do port scans of machines and find loopholes but they don't like that too much (if you know what I mean).

Oh well, at least we have internet, albeit slow. Not long ago


aid station in the middle of the night). So, we actually seek them out.

This truly captures the feeling of being there at Hardrock. Thanks, Bryon.

That's what I'm talking about! All sports interviews should be this good. Bryon, they need you at the Olympics. Thanks so much for this. All the excellent stuff. Top competitors supporting each other and so obviously enjoying each other's company. Exactly what the world needs more of. My kids and I keep watching this interview over and over. We all want to run this race someday. Just freaking love ultrarunners!!

I'm fairly sure that's Bob Bachani. At my first 100 mile finish, Javelina, I was met by Bob shouting "That's what I'm talking about" as I came in just under 24 hours. Didn't know the     nElements = sizeof(briefList) / sizeof(briefList[0]);
    }

    for ( i = nElements; i; i-- )
    {
         /* A thousand lines of optimized code */
    }
    this->needsDeepEvaluation = 0;
}

Most compilers will happily swallow the assignment of pArray, but chokes on the assignments of nElements. This inconsistency confuses me, and I would like to be enlightened.
I have no problem accepting that you can't assign a const integer, but then why does it works as I expect for the const-pointer-to-const?
The fast and cheap fix is to drop the const qualifier, but that might introduce subtle bugs since much of the code inside


       ['menuname', 'unique', 'with'=>'restaurantid'],
            [['restaurantid'], 'exist', 'skipOnError' => true, 'targetClass' => Restaurant::className(), 'targetAttribute' => ['restaurantid' => 'id']],
    ];
}

/**
 * @inheritdoc
 */
public function attributeLabels()
{
    return [
        'id' => 'ID',
        'master_menu_sepcality_id' => 'Master Menu Sepcality ID',
        'master_menu_type_id' => 'Master Menu Type ID',
        'item' => 'Item',
        'price' => 'Price',
        'restaurantid' => 'Restaurantid',
        'phase_id' => 'Phase ID',
     0.5669         0.5772         0.065\*
  C5    0.9177 (4)   0.52988 (10)   0.73139 (14)   0.0483 (4)
  C6    0.9618 (5)   0.45197 (11)   0.69313 (17)   0.0640 (5)
  H6    1.1124       0.4217         0.7440         0.077\*


the worst case scenarios, dpending on how one calculates the "average", the exact number could be a bit higher. My guess would be $1-\frac 1 e + \log_2 k$.
$k=0$ is indeed a special case, as $\log 0$ is not a real number (there are number systems in which it can be given as $-\infty$).

‘demonstration selling’). With a product like ours, her talk made us take a step back and rethink our approach.

Lou Lentine @ Viatek Consumer Products – Perfecting Your Product & Manufacturing: Viatek is a world leader in developing and marketing great products for both TV and retail. Lou's talk gave us insights on how to perfect a product and get it ready for mass distribution.

Bob Circosta @ HSN, TV's "Billion Dollar Man" – The Perfect Pitch: Bob was the first ever pitch man on HSN, launched over 75K products, totaling in over $5 billion in world-wide sales. He taught us some "tricks of the trade" which he has perfected over the years, including how to apply WSGAT (look it up) to your pitch.

Day 2 (Key Speakers)

Rodger Allen @ LSQ


is exempt from the tax because it is a sale for rental.
The Department appealed the hearing officer's proposed decision and in June 1986, the director of the Department reversed, concluding that the public's use of coin-operated video game machines was not a rental, and that the initial sale of these machines was not a sale for resale. The director ruled:
The initial sale is a sale of tangible personal property which is used and consumed in the arcade operator's business. The use of the machines by the general public is a sale of services.
Rowe in turn appealed this order to the Arizona State Board of Tax Appeals, Division Two, pursuant to A.R.S. § 42-1338.01.[3] After a hearing, the board denied Rowe's appeal, and later denied Rowe's motion for reviewgames on the machines, which was taxable to the businesses which purchased the machines from Rowe under the amusement classification of § 42-1314(A)(1). These two separate and distinct transactions result in the imposition of privilege taxes upon different "persons" who are taxed under different classifications for different privileges. See Miami Copper Co., supra.
Further, our holding that the proceeds from video game machines were taxable under former subsection (A)(1) does not violate the equal privileges and immunities provisions of the Arizona and United States Constitutions. Ariz. Const. art. 2, § 13; U.S. Const.Amend. XIV. Rowe's argument to the contrary is specious at best. There simply has been no showing that other similarly situated taxpayers who supply video game machines to arcades and other business establishments are not required to


first time under the guise of supplemental authority.[6]
We reverse the judgment of the trial court and remand for proceedings consistent with this opinion.
GERBER and FIDEL, JJ., concur.
NOTES
[1]  Unless otherwise indicated, all statutory references in this opinion will be to those in existence at the time the sales at issue took place.
[2]  Repealed by Laws 1985, Ch. 366, § 1, eff. July 1, 1986. See current § 42-122.
[3]  Repealed by Laws 1985, Ch. 366, § 1, eff. July 1, 1986. See current A.R.S. § 42-124(A).
[4]  In any event, video games are nothing but technologically evolved pinball machines, which originated in their modern form about 1930. 9 New Encyclopedia Britannica, Micropedia 447 (15th Ed. 1986).
[5]  A.R.S. § 42-1310.14 was subsequently renumbered as § 42-1310.13 and/*
 *   This program is free software: you can redistribute it and/or modify
 *   it under the terms of the GNU General Public License as published by
 *   the Free Software Foundation, either version 3 of the License, or
 *   (at your option) any later version.
 *
 *   This program is distributed in the hope that it will be useful,
 *   but WITHOUT ANY WARRANTY; without even the implied warranty of
 *   MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
 *   GNU General Public License for more details.
 *
 *   You should have received a copy of the GNU General Public License
 *   along with this


Q:

Question marks in string due to character encoding in Request.Form

I have a textarea where I type some unicode characters which become question marks by the time the string reaches the server.
On the input I typed the following:

Don’t “quote” me on that.

On the server I checked Request.Form["fieldID"] in Page_Load() and I saw:

"Don�t �quote� me on that."

I checked my web.config file and it says <globalization requestEncoding="utf-8" responseEncoding="utf-8" />. Anything else I should check to ensure UTF-8 is enabled?

A:

Once I again I solve my own problem. It is quite simple. The short answer is add the following before sending any response back to the client:
Response.ContentType = "text/html; charset=utf-8";

The long answer is that a "feature" called Cache Mode circumvented all other response data by writing a UTF-8 encoded file that is reallya Data Model. Some notable Data Models include a Relational Model, an Entity-relationship model, and an Object Model. The design and maintenance of a complex database can require highly specialized knowledge and skills by database application programmers, DBMS developers/programmers, database administrators (DBAs), etc. To assist in design and maintenance of a complex database, various tools can be provided, either as part of the DBMS or as free-standing (stand-alone) software products. These tools can include specialized Database languages (e.g., Data Description Languages, Data Manipulation Languages, Query Languages). Database languages can be specific to one data model or to one DBMS type. One widely supported language is Structured Query Language (SQL) developed, by in large, for Relational Model and can combine the roles of Data Description Language, Data Manipulation Language,


Whatever the media pundits say about a real-estate bubble, savvy investors know how to thrive at every point in the market cycle. All markets go through cycles. In this audio course, three of Trump's top real estate experts teach you how to buy "bubble-proof" properties, cash in on rising interest rates and develop a long-term outlook for real-estate values.

How to Think Like the Wealthy

You'll learn to let go of destructive beliefs like "money is the root of all evil", "money can't buy you happiness", "rich people get wealthy at the expense of the poor", and "rich people are 'filthy rich'" - and replace them with empowering beliefs like, "money gives me choices", "I will make a ton of money, have fun doing it, and be generous with it",and more. You'll learn the critical difference between an abundance mentality and a scarcity mentality - and how to develop and apply an abundance mentality right away.

How to Take Your Business Global

You've probably heard the often quoted statistic about entrepreneurial businesses: "95% of all new businesses will fail in their first five years." However, what you probably don't know is that, of those businesses that last past five years, the vast majority of those will fail in the next five years after that! Why is this? Pure and simple - competition. In a world where it is easier than ever before to start a business in the US, it takes little time for a competitor to enter your field and reduce your market share.


A + p \to k_1 + k_2 + k_3 + k_n$ of a projectile $A$ and a proton target $p$, leading to the four fragments in the final state, can be written in the following way $$\begin{aligned}
\sigma &=&  {(2\pi)^4 \over v_i} {1 \over \hat{J}_A^2 \hat{J}_p^2}
\sum \int d{\bf k}_1\ d{\bf k}_2\ d{\bf k}_3\ d{\bf k}_n\
 \nonumber \\
 &\times& \delta(E_f - E_i)\ \delta({\bf P}_f - {\bf P}_i)\
 {\mid {\it T}_{fi} \mid}^2,
\label{eq:cross}\end{aligned}$$ where $E_i = E_p + E_A$, $E_f = E_1 + E_2 + E_3 + E_n + Q$, ${\bf P}_i = {\bf k}_p + {\bf k}_A$, ${\bf P}_f = {\bf k}_1 + {\bf k}_2 + {\bf k}_3 + {\bf k}_{n}$ are the total energies and momenta of all particles before and after collisions, respectively. $Q=-3.70$MeV is the separation energydescribed by two relative Jacobi momenta $\mathbf{k}_x$ and $\mathbf{k}_y$ and the c.m. momentum $\mathbf{k}'$ of the three particles $$\begin{aligned}
{\bf k}_{x} &=& \mu_x \left( {{\bf k}_1 \over m_1} - {{\bf k}_2
\over m_2} \right), \quad \quad \, \mu_x = { m_1 m_2 \over m_{12} }
\nonumber \\
{\bf k}_{y} &=& \mu_y \left( {{\bf k}_1+{\bf k}_2 \over m_{12} } -
{{\bf k}_3 \over m_3} \right), \mu_y = { m_{12} m_3
\over  m_{123} } \nonumber \\
{\bf P}_f &=& 0, \quad \quad {\bf k}' = {\bf k}_1 + {\bf k}_2 + {\bf k}_3 =
-{\bf k}_4
\label{eq:jac}\end{aligned}$$ where $m_{12}$ = $(m_1 + m_2)$, $m_{123}$ = $(m_1 + m_2+ m_3)$. For each three-body decay event, the Jacobi momenta $\mathbf{k}_{x}$ and $\mathbf{k}_{y}$ define the decay plane. The *internal correlations* of the fragments \[shown by red color in Fig. \[fig:scheme\] (c)\] are defined


Be}$]{} but we will make emphasis on the analysis of the region of $\theta_{\rm Be} \in (45, 120)^\circ$ and $E_T < 3.1$ MeV \[see rectangle in Fig. \[fig:IMspectrum\] (b)\]. Both, the ground and first excited states, are well pronounced and are measured with sufficient statistics in this region. At smaller angles setup efficiency is severely suppressed by the telescope acceptance, while at larger angles population cross section is quite low. The model calculations were passed through a virtual measuring setup taking into account all major details of the experimental setup.

We will attempt to compare theoretical results with experimental data by fitting the three aspects of the density matrix related to investigated states:

\(i) Population ratio of the $0^+$ ground state to the $2^+$ first excited state;

\(ii) Intensity of the spin-alignment foralso very good in this work, it means that there is a complete agreement between this experiment and the experiment [@Egorova:2012]. The $^{6}$Be states were populated in a high-energy ($E_{\rm beam} \sim 70$AMeV) knockout from $^{7}$Be beam in experiment [@Egorova:2012]. This is very different reaction mechanism, so the internal correlations in the decay of relatively broad $2^+$ state seem to be not sensitive also to this aspect of the reaction mechanism.

[ESThetaAleft7590.eps]{} (-2,45)

[ESThetaAleft90120.eps]{} (-2,45)

The analysis of external correlations is illustrated by Figs. \[fig:ESThetaAleft7590\] and \[fig:ESThetaAleft90120\] for two selected $\theta_{\text{\scriptsize Be}} $ ranges. Again the sensitivity of the $\theta_{\alpha}$ angular distributions to the alignment/interference conditions is very high. However, we can find the density matrix parameters for which near perfect description of the distribution is provided. The results of our fits


value of ${\rm
\dot{M}}$.

Previous, lower spectral resolution X-ray observations of cooling flow clusters had provided hints of this problem - a deviation from simple model predictions at the lowest energies. However, the discrepancies to model fits in those cases were generally interpreted as evidence for absorption by cool clouds embedded in the cooling flow ([@jpeterson-B3:white]). For the RGS data, we can measure the intensities of the emission lines individually. It is clear from the raw data that absorption cannot explain this effect - the low energy lines are too weak, while the lower energy continuum is predicted correctly. Further, the RGS data make it clear that the failure of the model cannot be ascribed to the assumed elemental abundances. In particular, we see a deficit of low temperaturegalaxies, NGC 533 is shown in Figure 6. Here again, there is evidence for significant cooling below ambient temperatures. The ratio of Fe XVII to Fe XVIII, however, is roughly 1, while the prediction for the standard isobaric model is closer to 3. Our sample includes 14 clusters, which differ in inferred cooling-flow mass deposition rate by three orders of magnitude. In every case, the isobaric cooling flow models overpredicts the observed spectrum at the lowest temperatures. It appears that the [*total*]{} soft X-ray luminosity is roughly consistent with the predicted morphological mass deposition rate, but that the emission measure distribution is considerably steeper than this simple model would seem to require.

Empirical Parameterization {#empirical-parameterization .unnumbered}
==========================

We are able to fit the observed spectra reasonably well, however, using a variety


the problem of internal displacement is a worldwide one and accounts for nearly two thirds of the global forced displacement total.

South Sudan, the world´s fastest growing refugee crisis, has by now forced 1.9 million people to flee across the border.

"Turkey continues to be for the third consecutive year, the largest hosting country", said Grandi. That's 300,000 more people than the year before. Most fled the conflict in South Sudan.

There are plans to expand the programme and open similar sites throughout the country to give assistance and hope to millions of displaced people, although both hope and cash are in short supply.

The latest annual global trends study from the United Nations refugee agency (UNHCR) reports that one person was forced to leave their home every three seconds in 2016.The total figure includes refugees, asylum-seekers and people uprooted inside their own countries.

Among displaced people living there is Anjelina, who fled her home with her three children two years ago, first settling in one of the protection sites. The report attributed that slight reduction in part to people who had returned to their homes, offsetting the number of new people who had fled.

"Tragically, 75,000 asylum claims were received from children travelling alone or separated from their parent". There were another 2.8 million asylum seekers, the report said.

- Turkey hosts the largest number of refugees (2.9 million) followed by Pakistan (1.4 mln) and Lebanon (1 mln).

"The richest and most stable countries from Europe to the United States do their uttermost to keep refugees away".

Global Trends is a statistical assessment


As is well known in the gas turbine engine technology, the efficiency of the engine is greatly enhanced by increasing the temperature of the turbine and/or reducing the amount of air that is required to maintain the turbine components within their tolerable limits. In other words, the material used for the turbine blades must be able to withstand the temperature and hostile environment that is seen in the turbine section. Engineers and scientist have been working for many years at improvements to provide materials capable of withstanding higher temperatures and to reduce the amount of coolant for achieving satisfactory cooling of the turbine components and particularly the turbine blade.
An example of cooled turbine blades is exemplified in U.S. Pat. No. 5,720,431 granted to Sellers, et al on Feb.philosophy of this invention as compared to the teachings noted above and the results obtained by the utilization of this invention as a cooling technique for turbine blades will enhance the cooling effectiveness and hence, will improve the efficiency of the engine. Essentially, this invention relates to cooling the surfaces of the pressure side and suction side of the airfoil and provides a matrix of square or rectangularly shaped cells (although other shapes could also be employed), each of which have discrete cooling passage(s) formed in the wall of the airfoil adjacent to the pressure surface and to the suction surface of the blade resulting in a near wall cooling technique of the turbine airfoil. The matrix can be made to span the longitudinal and chord-wise directions to


Sungai Gerong

Sungai Gerong is an industrial area in South Sumatra, laying just east of the Palembang city, Indonesia. Built by SVPM, in 1912 where the operation started in 1926, starting the discovery of Petak field, in 1914, Trembule field, then Talang Akar found in 1921 as the company large investment, completion the crudes pipeline operations in 1952 from the South Sumatra oil-field.

In 1970, The Republic of Indonesia bought this refinery from PT Stanvac Indonesia to become part of its Government Oil Company, PERTAMINA.

Category:Petroleum in Indonesia
Category:Populated places established in 1912
Category:Populated places in South Sumatra
Category:1912 establishments in the Dutch East Indiesradiation. In particular, Raman spectroscopy analyzes the frequency shifts from monochromatic light, usually from a laser in the visible, near-infrared, or ultraviolet range, that inelastically scatters off molecules of the detection target. Because it is very specific for the chemical bonds in molecules, the frequency shift information obtained from Raman spectroscopy provides a fingerprint by which the molecules can be uniquely identified.
The main challenge of Raman spectroscopy is separating the weak inelastically scattered laser light from the more intense elastically scattered laser light. Accordingly, several types of Raman spectroscopy have been developed. One variation, called Surface-Enhanced Raman Spectroscopy (“SERS”), involves chemisorption or physisorption of molecules of a detection target to a substrate made of or containing a metal such as silver or gold. The incident and scattered light


This V-2 SQ Si-Trim Kit with an average of 9 Lbs. of boost will increase the factory engine's horsepower from 300 to 420 and the torque from 320 ft/lbs. to 385 ft/lbs. With this kind of reliable power on tap, it will be difficult to keep your car in the garage!1000)

run_algo(nodes, selectionSize);

public void run_algo(int[] nodes, int selectionSize) {
    randomNodesList = {};

    while(randomNodesList < selectionSize) {
        randomNode = selectRandomNode(nodes); // Assume O(1)

        if(!randomNodesList.exists(randomNode)) { // Assume O(1)
            randomNodesList.push_back(randomNode); // Assume O(1)
        }
    }

    foreach(node in randomNodesList) {
        foreach(neighbor in node.getNeighbors()) { // Max. nodes size (in this case 1000)
            if (!randomNodesList.exists(neighbor)) { // Assume O(1)


GE Dash 8.5-40CW

The GE Dash 8.5-40CW is 6-axle a 4,000 hp (2,800 kW) diesel-electric locomotive originally built by GE Transportation Systems, rebuilt by Norfolk Southern at its shops in Roanoke, VA. The first locomotive started rebuild 2012.

The locomotive is designed to meet Tier 2 emissions standards. All of the Dash 8.5-40CW's excluding 8500 and 8505 have been rebuilt with the Norfolk Southern-designed wide-nose RLS cab which meets current FRA crashworthiness standards. 8500 was rebuilt with an SD60E style Norfolk Southern-designed Crescent cab while 8505 was rebuilt with an ES44AC style GE cab. They have been equipped with the Traction and Engine Control Unit (TECU) from TMV Control Systems, upgraded from Manual Fuel Injection (MFI), to Electronic Fuel Injection (EFI), and equipped with NS-designed split cooling system. The rebuild also includesseen that it is almost as expensive as my Delphi license!
So, there is any free version of AQTime included in Delphi? If yes, what am I doing wrong? How do I make it work? If not, there is a way to remove the AQTime plugin from IDE? I could at least make the IDE load faster this way.

A:

That's right - the Standard edition of AQtime has some features missing. In your case, the missing feature you are trying to use is the line-level profiling - the thing that shows you links to specific code lines in the profiling results. The Standard edition can profile only on the Routine level - you will see routine names in the results and the call stacks (where appropriate), but without line numbers.


You can lear more about the differences here:
http://smartbear.com/products/development-tools/performance-profiling/standard-for-rad-studio-vs-pro/
So, to actually use AQtime Standard, open the Setup page and configure the profiling areas to be Routine-level. You can read more about this here:
http://smartbear.com/support/viewarticle/17718/
http://smartbear.com/support/viewarticle/17895/
The docs are for the standalone Pro version of AQtime (not integrated to the IDE), but the UI and the functionality is very similar, so you should be able to sort things out.

FOSDEM Video: Google Summer of Code - Some Insights

Linux Magazine Online has been talking to Leslie Hawthorn, one of the project managers for Google's hacker scholarship.

During FOSDEM in Brussels Leslie Hawthorn found the time to talk about her job, how much money is being spent for the Summer of Code, who could apply as mentor and what the company offering maps of the world is thinking about the free project Open StreetMap.


Dilution used was 1:1000), anti-β-Actin (Cell Signaling, MA; Cat\# 4970, at 1:2000 dilution) and anti- β~2~-AR (Abcam, MA; Cat\# ab36956; Dilution used was 1:1000). The methods described here are taken from our previous publication ([@B33]).

Mitochondrial Membrane Potential {#S2.SS6}
--------------------------------

Rhodamine 123 was used to measure the Mitochondrial transmembrane potential as described in [@B28]. To quantify the membrane potential, fluorescence signals observed in different conditions were measured (excitation wavelength used was 488 nm and an emission wavelength used was 510 nm) using a fluorescence microplate reader (biotex) and plotted as percentage.

Statistical Analysis {#S2.SS7}
--------------------

Origin 9.0 (Origin Lab) was used for all data analysis. Statistical significance was established either using Student's *t*-test or one-way ANOVA (*post hoc* using Tukeys or Fisher test when compared between more than 2 variables). All values indicated inthe figure are shown as means ± SEM or ± SD as stated in the figure legends. *p*-value are also indicated and 0 \< 0.05 or lower were considered significant.

Results {#S3}
=======

β-Adrenergic Receptor Agonist Protects Against Neurotoxin-Dependent Loss of Cells {#S3.SS1}
---------------------------------------------------------------------------------

Neurotoxins, such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) metabolite MPP^+^, induce a loss of DA neurons in most vertebrate animals including sub-human primates lower animals that show Parkinson's disease (PD) like symptoms ([@B5]). We thus used differentiated neuroblastoma SH-SY5Y cells that were treated with MPP^+^ to examine the effect of this neurotoxin on its survival. Consistent with our previous results ([@B36]), addition of neurotoxin, MPP^+^ showed an increase in cell death in differentiated SH-SY5Y cells ([Figure 1A](#F1){ref-type="fig"}). Importantly, pretreatment of SH-SY5Y cells with β-adrenergic receptor (β-AR) agonist, isoproterenol showed a dose-dependent increase


limit any off target effects. Furthermore, ISO-mediated protection was dependent on TRPM7 expression, as TRPM7 silencing cells failed to show increased cell survival even in the presence of isoproterenol. Moreover, apoptosis was increased in cells treated with siTRPM7 even in the presence of isoproterenol. In contrast, restoration of TRPM7 expression increased intracellular Mg^2+^, inhibited apoptosis, and promoted cell survival. These results further emphasize the importance of TRPM7 as expression of other Mg^2+^ transporters were unable to overcome the loss of TRPM7. β-AR agonists, have been shown to increase the survival of DA neurons ([@B23]; [@B33]), however, the mechanism is not clear. Based on our findings, we postulated that β-AR agonist activates TRPM7 channel activity that could modulate the survival of DA cells/neurons. Importantly, TRPM7 levels were decreased inprimary goal was religious and we wanted something to bond over and get to know each other socially.”

Andrew Lord is president of Cornell’s Interfraternity Council. He said the school’s 2,200 fraternity members welcomed Alpha Lambda Mu.

He said that one of the reasons he likes Cornell’s fraternities is that people of all races and religions are welcome.

Besides Cornell, Penn State and the University of Texas at Dallas, there are Alpha Lambda Mu chapters at University of California at San Diego, the University of Toledo, San Diego State University and University of Texas at Arlington.

Words in This Story

co-ed- adj. involving both men and women

inspired - adj. very good or clever

pizza - n. a food made from flat, usually round bread that is topped with usually tomato sauce and cheese and


often with meat or vegetables

basketball court - n. where a game is played in which two teams of five players bounce a ball and try to score points by throwing the ball through one of the raised nets at each end

soccer - n. a game played between two teams of 11 players in which a round ball is moved toward a goal usually by kicking

peer pressure - phrase, when people in your group or school put pressure on you to do something
      {
         cblas_xerbla(2, "cblas_dsymm","Illegal Side setting, %d\n", Side);
         CBLAS_CallFromC = 0;
         RowMajorStrg = 0;
         return;
      }

      if( Uplo == CblasUpper) UL='U';
      else if ( Uplo == CblasLower ) UL='L';
      else
      {
         cblas_xerbla(3, "cblas_dsymm","Illegal Uplo setting, %d\n", Uplo);
         CBLAS_CallFromC = 0;
         RowMajorStrg


of comedians are the ones that tell a lot of stories. One of my favorites is Mike Birbiglia. Everyone I have talked to about him seems to have a love or hate feeling towards his comedy. I think a lot of it comes from the fact that he doesn't constantly keep people laughing, but once he gets to the punchline it is worth the build-up.

jmc88Post 6

I think impressionists have the ability to be some of the best and worst types of comedians at the same time. The person I immediately think of is Frank Caliendo. He can impersonate tons of people, and he is really good at it. The only problem is that people get tired of the same routines after a while. For example, his impressions ofNecessary and sufficient conditions for copositive tensors. Linear and Multilinear Algebra, 63(1), 120-131 (2015).

[^1]: Corresponding author. School of Mathematics and Information Science, Henan Normal University, XinXiang HeNan, P.R. China, 453007. Email: songyisheng1@gmail.com. The work was partially supported by the National Natural Science Foundation of P.R. China (Grant No. 11171094, 11271112, 61262026), NCET Programm of the Ministry of Education (NCET 13-0738), science and technology programm of Jiangxi Education Committee (LDJH12088).

[^2]: Department of Applied Mathematics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong. Email: maqilq@polyu.edu.hk. This author’s work was supported by the Hong Kong Research Grant Council (Grant No. PolyU 502111, 501212, 501913 and 15302114).


[@LOZ].

Connection between XYZ and XXZ$^{'}$ tops
==========================================

In this section we explain the interrelation between the bosonisation formulas corresponding to $XYZ$ and $XXZ^{'}$ tops. In the limit $k\rightarrow0$ the elliptic Weierstrass function behave as: $$\wp(q,k)\rightarrow\dfrac{1}{\sin^2(q)},$$ and the Hamiltonian of elliptic the Calogero-Moser system is transformed into the trigonometric one. Thus, it is natural to suppose that in this limit $XYZ$ top transform into $XXZ^{'}$ top. However, the matrices of quadratic forms defining these tops are not transformed into each other in this way. To understand what is really going on let us consider the behavior of the bosonisation formulas in the limit $k\rightarrow0$. From equations (\[bfell1\])-(\[bfell3\]) we can find: $$\begin{aligned}
&&S_{1}\rightarrow-p\dfrac{\cos(2q)}{\sin(2q)}+\nu\frac{1}{\sin^ 2(2q)}\\
&&S_2\rightarrow\frac{1}{i k}\Phi(q,p),\\
&&S_3\rightarrow\frac{1}{k}\Phi(q,p),\end{aligned}$$ where $$\Phi(q,p)=p\frac{1}{\sin(2q)}-\nu\frac{\cos(2q)}{\sin^2(2q)}.$$ Thus, in this limit the bosonisation formulas diverge. To obtain a finite expressions we needsites outside of the laboratory, and being performed by non-laboratory staff, ensuring test quality and accuracy of results have become key considerations in HIV programmes.^[@CIT0006]^

Current point-of-care technologies for CD4, early infant diagnosis and viral load testing {#s0002}
=========================================================================================

To date, there are two approved (World Health Organization-prequalified) POC platforms for CD4 and two for EID, whereas POC viral load platforms are in the evaluation pipeline.^[@CIT0007]^ Most of these POC technologies provide sample-in/answer-out diagnostic testing, making it possible for these tests to be performed with minimal training, outside of the traditional laboratory setting. Most of the devices can withstand extreme transport and environmental conditions, provide a test result in less than one hour and have data transmission capabilities. Some (and more are in development) can even operate on battery power.^[@CIT0008]^

The rollout


of God in denouncing Christmas, however, might we not better cultivate the bits of truth that shine through the lamentable commercialization and paganism? This is a unique time of year for presenting the gospel to the world, so let us take advantage of the opportunity.

Christ's birth and the details of His life, death, and resurrection were foretold centuries before by the Hebrew prophets. No such prophecies preceded the births of Buddha, Confucius, Muhammad, et al. Biblical prophecy fulfilled is the most powerful persuader we have. Paul used it in converting the lost and turned the world of his day upside down. So should we.

In Romans 1:1-4 we see Paul's approach. He refers to "the gospel of God, (which he [God] had promised afore by his prophets in theGod, which taketh away the sin of the world" (Jn 1:29), was likewise on display before Israel. On the fourteenth of Nisan, "the whole assembly of the congregation of Israel shall kill it [the passover lamb] in the evening [between 3:00 and 6:00 P.M.]" (Ex 12:6). It was during that precise time period that Jesus died on the cross!

It is fascinating to see how God uses man's decrees and even man's connivings against Him to fulfill His Word. The rabbis had determined not to arrest Jesus during Passover, "lest there be an uproar of the people" (Mk 14:2). Yet that was when He had to die. Judas was not only Satan's pawn, but God's. Even the "thirty pieces of silver" he so shrewdly bargained for fulfilled prophecy (Zec


13:1). The word "he" is in italics and does not appear in the original. Jesus was declaring once again to His disciples that He was Yahweh, the I AM of Israel, who tells beforehand what will happen and makes certain that it comes to pass (Is 46:9-10).

Arrested by the Judas-led troop in the Garden later that night, Christ was taken secretly to the palace of Caiaphas, the high priest. A sham trial before the Sanhedrin, with hastily called false witnesses, convened sometime after midnight, condemned Christ to death as dawn broke. Shortly thereafter, Pilate, the Roman governor, was notified of the emergency. Hurriedly taken down side streets, the prisoner was received into the citadel at "the third hour" (Mk 15:25), about 9:00 A.M., Nisan 14. All over Israelpreparations were underway to kill the passover lamb, which was to be eaten that night.

Jerusalem was crowded and in a state of great excitement. Valuing public relations, Pilate consulted his ever-volatile citizens and let them decide the prisoner's fate. Incited by the rabbis, the bloodthirsty rabble suddenly turned against the One who had miraculously healed and fed so many of them. "Crucify him, crucify him" (Lk 23:21). "His blood be on us, and on our children" (Mt 27:25). The horrible chant echoed down Jerusalem's narrow streets.

Shortly before noon, the soldiers had finished their vicious, depraved sport. Jesus, scourged almost into unconsciousness and beaten about the face until He was nearly unrecognizable, was led through the frenzied, screaming mob out of the city to "the place of the skull."


the layout for the App Widget and attach an on-click listener
            // to the button
            views = new RemoteViews(context.getPackageName(),
                    R.layout.widgetlayout);

            views.setOnClickPendingIntent(R.id.ivCal, pendingIntent);
            views.setOnClickPendingIntent(R.id.tvParkStatus, pendingIntent);
            views.setOnClickPendingIntent(R.id.tvToday, pendingIntent);

            new GetJSON().execute();

            views.setTextViewText(R.id.tvToday, t1);
  two groups.

Results
=======

IGF-1 administration significantly ameliorates UUO-induced kidney injury
------------------------------------------------------------------------

UUO is a well-established renal injury model and it creates progressive renal fibrosis. IGF-1 has been shown to ameliorate renal injury and the subsequent development of renal fibrosis. Thus, we tried to reproduce these data before we addressed the underlying mechanisms. Therefore, we performed UUO on mice, while some of which received daily i.p injection of IGF-1 (UUO+IGF-1), while the other received daily i.p. injection of saline as a control (UUO). Another group of mice that received sham operation were also daily i.p. injected with saline as another control (Sham). At 3 days after UUO, we digested the kidney from some of the mice for sorting of renal epithelial cells by fluorescence-activated cell sorting (FACS). These purified renal epithelial cells were


whether miR-429 has a similar effect on Bcl-2 in renal epithelial cells[@b9][@b10][@b11]. Indeed, post-transcriptional regulators of gene expression, such as miRNAs are increasingly recognized as differentially regulating protein expression and playing a key role in the pathological processes in the renal diseases. The revealed miRNAs that were regulated by IGF-1 are miR-1, miR-103 and miR-133a[@b35][@b36][@b37][@b38]. To the best of our knowledge, the current study was the first report showing that miR-429 is regulated by IGF-1, and in an ERK/MAPK-p42/p44-signaling pathway-dependent manner.

Here, by sequence matching using bioinformatics analyses, we found quite a few of candidate miRNAs that target Bcl-2, including miR-429, miR-30, miR-22, miR-25, miR-32, miR-92, miR-363, miR-367, miR-99, miR-27, miR-128, etc. Among all these miRNAs, we specifically detected a significant change in miR-429 by UUO and IGF-1, comparedand comparing like with like across the whole range of the keyboard resulted in sounds that I would classify as very similar, but just slightly brighter/warmer/louder/softer (delete as appropriate on a tab-by-tab basis). Elsewhere, the 2-2/3 tab in the Boost section is rather louder in Farfisa V than on my Compact Deluxe, whereas the overall tone of the original — especially when using the Multi-Tone Booster tabs — is more aggressive, as I had expected it to be. On the other hand, the Compact on which Arturia modelled Farfisa V must have had a louder key click than any Farfisa that I’ve ever played because (in my view) Farfisa V has a bit too much. This is often masked in complex sounds, but it leaps out when playing


as well as various synth-like sounds and effects. If you were expecting something that sounded like a Farfisa Compact and little more, some of these will surprise you.

Almost every parameter within the organ, the stompbox effects and the amplifier can be controlled via MIDI, whether for programming, real-time control or automation.

In addition to all of this, and in stark contrast with the simple bass section of the original organs, Farfisa V offers nine user-selectable bass waveforms followed by a resonant 24dB/octave low-pass filter. Two of these waveforms are the Soft and Sharp waves generated by the standard Farfisa tone generators, two are the additive and user waves defined by the 48 faders, while the other five are standard synth waveforms: sawtooth, hard-sync sawtooth, square and modified square (whatevercharacteristics, pedal noise, soundboard resonance, lid position and more. You can then further modify the sound by adjusting the positions of the four virtual microphones that capture it, as well as the reverberation characteristics of the virtual room in which the piano is sitting. Using a KeyLab88 as controller, I was able to craft and play a huge range of realistic and otherworldly pianos using Piano V and — although I didn’t delve deeply — I was happy with both the tone and the degree of control, although my experience was marred by an inconsistent response to both the Kurzweil and Roland damper pedals that I tried with it. The UVI and Pianoteq pianos still worked perfectly on the same system, so I’ll be keen to try Piano-V


a great deal to Farfisa V.

There’s a final signal-processing stage in the form of a Fender Twin combo emulation, with drive, master volume, brightness on/off, its own set of EQ controls, plus an option to select between on- or off-axis positions for the virtual microphone. Whether used independently or together, the amp and effects add hugely to the flexibility of the instrument.

The Farfisa Compact range of organs comprises historically important instruments that are notoriously difficult to synthesize. Farfisa V makes a very creditable stab at recreating them and, as is often the case with Arturia’s soft synths, offers considerably more that just emulation. If you crave the sounds of the original without the maintenance costs (or the weight!) you should definitely consider this.[Sanshan Medical Training School of Fujian in modern times].
TCM education in Fujian started at Sanshan Medical Training School in modern times. Approved by the Ministry of Internal Affairs in November 1911 and opened on October 5, 1917, the school was established by CHEN Dengkai, a famous doctor in Fujian. CHEN had begun to compile the texts before its establishment. The school had a 4-year education system (3 school terms in a year) and offered 23 courses including TCM and western medicine. Both the course and texts embodied CHEN's TCM-oriented, western medicine-assisted concept, which was also the contemporary trend of confluence of Chinese and western medicine.


A biography of Saul, The Sins of Jack Saul by Glenn Chandler, the writer of television detective series Taggart, was published in 2016, with a revised 2nd edition issued later the same year. It revealed hitherto unknown details about Saul's life before and after Cleveland Street. A musical of the same name based on the book, written by Chandler with lyrics by Charles Miller, premiered in London in May 2016, in which Jack McCann originated the role of Jack Saul.

Saul has also featured prominently in a large number of academic studies, and histories, including Morris Kaplan's Who's Afraid of John Saul?, Neil McKenna's The Secret Life of Oscar Wilde and Fanny and Stella: The Young Men Who Shocked England, and three books on the Cleveland Street Scandal, includingour baskets with armfuls of greens and veggies, not really knowing the recipe plan ahead.

I have heard this one before.. Hi. I just bought a bunch of kale, red radishes, two yellow bell peppers, some celery, an avocado, two gallons of coconut water, a knobby bit of ginger and nine lemons. What do I do now?

Our indulgent holiday gift list is now replaced with a wish list of healthy new year habits. No sugar. Less caffeine. Goodbye carbs. Hello green juice. Less alcohol. More whole grains. Less gluten. More sleep. More yoga. More water-drinking. And on and on.

But enough of the wish lists and high hopes. Enough of the rage and craziness. Stop fighting your body. It only wants to help you. It wants you to get healthy,


Ultraviolet exposure and vitamin D synthesis in a sun-dwelling and a shade-dwelling species of Anolis: are there adaptations for lower ultraviolet B and dietary vitamin D3 availability in the shade?
We compared the natural ultraviolet B (UV-B) exposure, dietary vitamin D, and skin-generated vitamin D synthesis for adult males of two species of Jamaican anoles. The more shade-tolerant and thermal-conforming Anolis lineotopus merope, rarely exposed to full sun, experienced less UV-B irradiation in its shady environment than the more heliophilic and thermophilic Anolis sagrei, which frequently basked in full sun during the morning hours (0800-1100 hours). Both species obtained detectable levels of vitamin D(3) in their diet, but the heliophilic A. sagrei obtained more. To compensate for less availability of UV-B and dietary vitamin D, the skin of A.ISSUE
The Court of Appeals also held Pierce's testimony concerning prior cocaine use and purchase of crack the following day was inadmissible under State v. Lyle, supra.
As with the res gestae issue, we find the subsequent purchase of crack with the money from the stolen saws was properly admitted under Lyle as evidence of motive. However, we agree with the Court of Appeals that Pierce's testimony concerning the prior cocaine use and thefts did not meet the requirements to be admitted under Lyle.
Evidence of other crimes or bad acts is generally inadmissible to prove the bad character of the defendant or that he acted in conformity therewith. Such evidence is admissible, however, when it tends to establish motive, intent, absence of mistake or accident, a common scheme or plan


                      6
By introducing the above-described warping prediction, it is possible to accurately approximate the motion vectors of an image sequence and realize a high data compression ratio. However, the throughput for coding and decoding decreases compared to a conventional method. Particularly, the divisions performed in the equations 5 and 6 are large factors for complicating the processing. Therefore, the warping prediction using affine transform and bilinear transform has a problem that the throughput for synthesizing a predicted image decreases.Slap Ya Mama’s communique said the company’s advertising representative — Walker & Sons Inc. — received an email from Cox Media Louisiana Director of Sales Marc Leunissen informing them that “in light of the domestic violence issues facing the NFL, (the league) instructed CST (to) pull the Slap Ya Mama logo from our enhancements in the last (preseason) game,” which is Thursday in New Orleans against Baltimore. Walker & Sons says it believes the NFL told Cox Media to do this Monday.

Thus, the league avoids having an advertisement with “Slap Ya Mama” show up on the field in a game where Ray Rice, recently the focus of much national discussion after the NFL’s two game suspension, will be playing.

According to Jack Walker, the Vice President of Marketing of


force that stands for strength, courage, pride and respect.” [emphasis ours]

The “Slap Ya Mama” phrase could be viewed as violent, in a vacuum. But its positive meaning–talking about a mama making food so good you want to make a loving gesture–is certainly distinct from any disparagement, right?

In a Native American community poll nine out of 10 supported the name and eight out of 10 in the general population would not like us to change the name, so we’re listening and being respectful for those who disagree but let’s not forget this is the name of a football team.”

Walker, on whether his company’s product name was offensive to mothers: “Maybe 2 out of 100 mothers might have an issue with the name, or may have said something about theto -2 volts (worst case).  If Not worst case : possibly output up to 5 volts and down to -5 volts. Don't even try to use the 741 with a single 5 volt power supply.
Using single supply (with or without virtual ground) :  Suppose +15 volts is used for Vcc, and Vee = ground.  Output could go up to 10 volts and only as low as 5 volts (worst case).  You might get the 741 to go as low as 2 volts, but not lower.  Output can never get close to 0 volts (ground).
Current technology (and inexpensive) has what is caled “rail to rail output”.  This means the output can approach the rails (Vcc and Vee)


the use of the deep freezing distillation, it is not easy to separate ethylene contained in the pyrolysis gas. In general, the method for recovering ethylene from the pyrolysis gas begins by separating C4+ hydrocarbons having relatively high boiling points, and then has a step for separating C1 hydrocarbon (methane) and hydrogen. The separation of C2 and C3 hydrocarbons is the final stage of the recovery process. Among these steps, it is very difficult to separate ethane and ethylene because of their small differences in relative volatilities.
Ethylene is the smallest unit of hydrocarbons containing a double bond and is the major product of the petrochemical industry. Various copolymers can be produced by polymerization using the double bond of ethylene or reaction between the double bond of ethylene andbut still the pope refused to release his refugee. Gregory even wrote to ask Charles Martel, Duke of the Franks, for assistance. Charles, however, refused.

In December 740, Transamund recovered his duchy and killed Hilderic with Papal-Beneventan aid, but did not return the confiscated papal cities and his alliance with the pope ruptured. Liutprand did not recognise Transamund's reconquest and set out to dispossess him a second time. This time Liutprand met with Gregory's successor, Zachary, in 742 and, promising to restore the four towns, allied with the Romans and forced Transamund to flee again. Transamund was caught and put in a monastery. Agiprand, Liutprand's nephew, was put in his place. The new duke of Benevento, Godescalc, who had succeeded Gregory without royal assent and continued to support Transamund,


of a semiconductor substrate 10, such as a silicon substrate, to define an active region. Gate patterns are formed, crossing over the active region and the isolation layer 12. Each of the gate patterns includes a gate electrode 14 and a hard mask pattern 16 that are sequentially stacked. The hard mask pattern 16 is formed from a silicon nitride layer. Spacers 18 are formed on sidewalls of the gate patterns. The spacers 18 are also formed of a silicon nitride layer. An inter-layer insulating layer 20 is formed on the substrate having the spacers 18, and the inter-layer insulating layer 20 is planarized using a chemical mechanical polishing (CMP) technique until the hard mask patterns 16 are exposed. The planarized inter-layer insulating layer 20 is patterned towith the anisotropically etched USG layer 22′ as shown in FIG. 2. Contact plugs 24, i.e., silicon plugs, are formed in the self-aligned contact holes surrounded by the anisotropically etched USG layer 22′ using a selective epitaxial growth (SEG) technique.
The anisotropically etched USG layer 22′ is formed in order to enhance a selectivity with respect to silicon during the SEG process. If the SEG process is performed on the substrate where the hard mask patterns 16, the spacers 18 and the planarized inter-layer insulating layer 20 are exposed, it may be difficult to find out an optimal process condition that does not cause crystalline defects, such as dislocations and/or stacking faults, in the silicon plugs 24. Accordingly, when the USG layer 22′ is formed, it can be easier


Design” line of body accessories for Electrodyne.

We chatted at length about the body accessory business, and eventually asked him the question that everyone’s dying to ask – where do you get the cars for your “test” vehicles? Do you buy them, get them from the factory, or what?

“That’s where Roadfly really became an asset to us. Not only were we generating sales from advertising with Roadfly, we were also able to post to the forums, asking members to let us borrow their cars so we could make new accessories without having to buy a car for everything we wanted to build,” says Chet. “Through their enthusiastic membership, we’d get all sorts of people who were willing to let us test fit parts and pieces, and it worked out Thomas James entered a conditional guilty plea to conspiracy to make
and pass counterfeit checks, produce fraudulent identification documents, and
use unauthorized access devices; access device fraud; and aggravated identity
theft. He appeals the district court’s denial of his motion to suppress evidence
found during a search of a stopped rental car in which he was a passenger. The
district court found that James lacked standing to contest the search of the car.

       * Pursuant to 5TH CIR. R. 47.5, the court has determined that this opinion should not
be published and is not precedent except under the limited circumstances set forth in 5TH
CIR. R. 47.5.4.
    Case: 18-30834     Document: 00514970768       Page: 2


Q:

NSLog executes immediately rather than at end of loop

I have the following code inside of an IBAction. I'd like to measure the exact amount of time it takes AVSpeechSynthesizer to run through a list of directions. However, executionTime gets logged immediately rather than at the end of the loop (returning less than a second rather than the 10-15 seconds I expected). What did I do wrong?
NSDate *methodStart = [NSDate date];

for (NSString* direction in directions) {

    AVSpeechUtterance *aDirection = [[AVSpeechUtterance alloc] initWithString:direction];
    aDirection.rate = .3;
    [self.synthesizer speakUtterance:aDirection];
}

NSDate *methodFinish = [NSDate date];
NSTimeInterval executionTime = [methodFinish timeIntervalSinceDate:methodStart];
NSLog(@"executionTime = %f", executionTime);

A:

That's because the speakUtterance call is asynchronous.
Make your class implement the AVSpeechSynthesizerDelegate protocol and set it as the AVSpeechSynthesizer's delegate, and finally implementever-popular Sleipnir command battlecruisers and the fast-but-deadly Machariel faction battleships.

However, the wholesale ship rebalancing that has taken place over the last year or so has completely rewritten the playbooks and we're seeing new trends rising. The Gallente Dominix battleship (unkindly described as the space potato) has seen some favour in the early matches and the Heron frigate has been identified as the ship which provides the cheapest mid-slot to tournament points ratio in-game, meaning it can fit more useful support gear.

Of the many entertaining clashes that took place over the course of the day, three in particular stood out...

The Battles of Champions

Reigning champions Verge of Collapse took on contenders Outbreak. in what transpired to be battle of the Dominixes.

Outbreak. took the early advantage by successfully targeting the Verge


package vcs

import (
	"bytes"
	"io"
	"io/ioutil"
	"os/exec"
	"path/filepath"
	"strings"
)

func init() {
	Register(newHg, "hg", "mercurial")
}

type MercurialDriver struct{}

func newHg(b []byte) (Driver, error) {
	return &MercurialDriver{}, nil
}

func (g *MercurialDriver) HeadRev(dir string) (string, error) {
	cmd := exec.Command(
		"hg",
		"log",
		"-r",
		".",
		"--template",
		"{node}")
	cmd.Dir = dir
	r, err := cmd.StdoutPipe()
	if err != nil {
		return "", err
	}
	defer r.Close()

	if err := cmd.Start(); err != nil {
		return "", err
	}

	var buf bytes.Buffer

	if _, err := io.Copy(&buf, r); err != nil {
		return "", err
	}

	return strings.TrimSpace(buf.String()), cmd.Wait()
}

func (g *MercurialDriver) Pull(dir string) (string, error) {
	cmd := exec.Command("hg", "pull", "-u")
	cmd.Dir = dir
	err := cmd.Run()
	if err != nil {
		return "", err
	}

	return g.HeadRev(dir)
}

func (g *MercurialDriver) Clone(dir, url string) (string, error) {
	par, rep := filepath.Split(dir)
	cmd := exec.Command(
		"hg",
		"clone",
		url,
		rep)
	cmd.Dir = par
	cmd.Stdout = ioutil.Discard
	if err := cmd.Run(); err != nil {
		return "", err
	}

	return g.HeadRev(dir)
}

func (g *MercurialDriver) SpecialFiles() []string {
	return []string{
		".hg",
	}
}
Q:

Use batch file to lookup text in CSV & parse it in to run an application install

I have an application that is to be deployed to 1000+ Windows machines. Each machine is in a remote office and is given a Node ID 1-35 and a Branch ID eg. 001122 (unique to each office). I have the install running silently but at one point it asks you to enter the Node ID and Branch ID. I am using the below code in a batch file to allow the engineer running the install to enter the details manually but this is very time consuming and we would prefer to have no user interaction.
We have all the hostnames, IPs, Node ID and Branch ID in one CSV.
My question is, is it


Boots had done in the late hours. Boots asked Briggs how he knew about all of his activities, and Briggs explained he had hired a private detective. Boots said, "That's a waste of your money, Mr. Briggs. You ought to assign him to some other player. You know darn well what I'm going to do." Boots told Briggs he should give Boots the money he was giving to the detective and Boots would tell them where to go. "All they’d have to do was go to the beer joint closest to the ballpark."

Boots' final years in the Major Leagues (1938–1939)
After a strong rookie season, Boots held out for more money. When he returned, he was not able to match the success of his rookie season, finishing the season- 5*h
Let p(c) = -2*c**2 - 15*c + 5. Let t(n) = n**2 + 14*n - 4. Give -3*p(x) - 4*t(x).
2*x**2 - 11*x + 1
Suppose 3*n = 23 - 11. Let d(f) = 17*f**2 + 9*f - 9. Let t(r) = 4*r**2 + 2*r - 2. Give n*d(p) - 18*t(p).
-4*p**2
Let s(b) = -3*b + 6. Let a(h) = 2*h - 5. Let r be 12/(-8) - 6/4. Give r*s(l) - 4*a(l).
l + 2
Let g(t) = -3*t + 5. Let h(l) = -14 + 4 + 0 + 16*l - 18. Determine -28*g(x) - 5*h(x).
4*x
Let k(p) = -9*p**3 - 16*p**2 - 8. Let f(r) = -3*r**3 - 5*r**2 - 3. What is 8*f(a) - 3*k(a)?
3*a**3 + 8*a**2
Let j(v) = -v**3 - 4. Let w(k) be the third derivative of


enable you to explore an area of interest in greater depth by taking a position (pro or con) in response to a contemporary digital preservation issue. You do not have to personally agree with which side you take on the issue, but you are expected to provide supporting evidence for whichever angle you choose, either affirmative or negative. The assignment is designed to help you learn to construct a solid argument and to begin building your own personal philosophy of preservation.

Final Project: Digital Preservation Policy (20% of total grade, supports SLO #5, SLO #6 and competencies F, N) For this assignment, you will establish a relationship with a local institution (library, archive, public radio/tv affiliate, business, etc) that is building its digital collections and that has not yetQ:

GlobalEntry / TSA Pre never works at Columbus International Airport. Why?

I applied for and received a Global Entry identification card about a year ago. Along with Global Entry, the card is also eligible for TSA Pre.
On every occasion, when departing from Columbus International Airport (CMH) I've gone into the TSA Pre line only to be told I can't use the card and have to go to the back of the standard security line.
The card has worked fine when entering through Global Entry. As well as the TSA Pre lines at other airports.
I've never received a satisfactory answer as to why I can't enter through TSA Pre at CMH. The most I've been told is it has something to do with my airline ticket and not being pre-approved.
Thankfully,


Abstract artist Robert Hunter writes on his Artspan site, “Art is fun and good for the soul! This is a solid doctrine to live by and helped me through years of teaching thousands of high school students, including Kurt Cobain.” Hunter was kind enough to answer a few questions about what Cobain was like as a young art student.

1. What grade(s) was Cobain in when you taught him? Kurt came to Aberdeen High School as a transfer from nearby Montesano. He was enrolled in basic art classes and commercial art Sophomore year and his Junior year. He was to take more art his senior year but dropped out.

2. Did he seem to enjoy art? What was his style like?

Kurt loved Art!!! He was a prolific drawer even aftersite, or facebook-like site that runs on the blockchain, but there’s no real necessity for them to run on one. Wikipedia works just fine being on the regular ol’ capital-I Internet. I think blockchain technology has a place in the world, and I think that place is growing every day. But I just don’t see a huge need for dApps right now. At least not for things the general public would need.”

What do you think? Will there be any need for these dApps to become more popular in the future? If so, then how long into the future would you estimate? Leave us a comment below.


last year's premiership decider.

Meanwhile, Greater Western Sydney collected the draft points to match bids on Academy graduates Jacob Hopper, Matthew Kennedy and Harrison Himmelberg.

Putting the feelers out for a trade with any club might have also been worthwhile.

In 2015, a package involving North Melbourne's second and third selections would have been worth the equivalent of pick No.14 based on the AFL's Draft Value Index. Daniel Rioli, Tom Doedee and Jade Gresham fell in that area of the draft.

In 2016, its second and third picks would have netted the equivalent of pick No.17. Jarrod Berry, Sam Powell-Pepper and Alex Witherden remained on the board this stage.

Options were available, with clubs in the same drafts trading down from those positions. The Western Bulldogs did so in 2015, while Port Adelaideto proliferation. USP5 regulates p53 levels and alters cell growth and cell cycle distribution associated with p21 induction in melanoma cells \[[@B52-ijms-21-02548]\]. OTUD1 is required for p53 stabilization, and OTUD1 overexpression increases the cleavage of caspase-3 and PARP and subsequently increases apoptosis \[[@B38-ijms-21-02548]\]. Another p53-associated DUB, otubain 1 (OTUB1), is expressed in high-grade tumor types, such as lung, breast, and ovarian tumors. OTUB1 regulates p53 to promote tumor cell survival and proliferation \[[@B37-ijms-21-02548]\]. USP42 controls the level of p53 ubiquitination during the early phase of the DDR to promote DNA repair, resulting in the activation of p53-dependent transcription and cell-cycle arrest in response to stress \[[@B45-ijms-21-02548]\]. In addition, USP28 depletion leads to increased ubiquitinated H2A-K119 and decreased expression of p53, p21, and p16INK4a, suggesting a role for USP28