polysome lysis buffer (20 mM Tris pH 8.0, 140 mM KCl, 1.5 mM MgCl2, 100 μg/mL CHX, 1% Triton X-100) was dripped into a 50 mL conical tube filled with and immersed in liquid nitrogen, containing the harvested yeast strip/pellet from a mid-log phase 300 mL biotin-induced culture. The frozen cell-buffer mixture was cryogenically pulverized for a minute in a freezer mill. Pulverized cells were thawed and centrifuged for 2 min at 4°C and 20,000 x g. The supernatant was immediately loaded onto pre-chilled, 2 mL Zeba de-salt spin column previously equilibrated with polysome gradient buffer (20 mM Tris pH 8.0, 140 mM KCl, 5 mM MgCl2, 100 μg/mL CHX, 0.5 mM DTT) according to the manufacturer's instructions. Aliquots of this extract were flash-frozen in liquid nitrogen andby CRISPRi {#s4-6}
-----------------------------------------------------

CRISPRi HeLa cell lines were generated by transducing with pHR-SFFV-dCas9-BFP-KRAB (Addgene ID: 46911) and sorting for BFP positive cells ([@bib15]). EMC2 (GAGTACGCGTCCGGGCCAA), EMC4 (GTCATTTCCGCCCTGGAAAT) and negative control Gal4-4 (GAACGACTAGTTAGGCGTGTA) protospacers were cloned into a lentiviral expression plasmid expressing guides from a mouse-derived U6 promoter, BFP and puromycin (pU6-sgRNA EF1-Alpha-puro-T2A-BFP; Addgene ID: 60955). HeLa CRISPRi cells were transduced with guide RNA expression plasmids, selected in puromycin for 72 hr and either directly used for experiments or expanded for SILAC labeling. HeLa cell lines were confirmed by STR analysis and tested as free from mycoplasma contamination.

Mammalian ribosome profiling  {#s4-7}
-----------------------------

Ribosome profiling was performed for HeLa-dCas9-KRAB cells, and HeLa-dCas9-KRAB cells expressing EMC2 or Gal4-4 control guide RNAs. Cells were cultured in 15 cm plates with Dulbecco modified eagle medium (DMEM) with


and accompanying author responses. A lightly edited version of the letter sent to the authors after peer review is shown, indicating the most substantive concerns; minor comments are not usually included.

Thank you for submitting your article \"The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins\" for consideration by *eLife*. Your article has been favorably evaluated by a Vivek Malhotra (Senior Editor) and three reviewers, one of whom is a member of our Board of Reviewing Editors. The following individuals involved in review of your submission have agreed to reveal their identity: Gunnar von Heijne (Reviewer \#2); Ari Helenius (Reviewer \#3). The complete, un-redacted comments of all three are posted below.

We have discussed the reviews with one another and have drafted this decision topretty clear that even in the absence of the EMC they will be inserted (at least some of their TMs) and not completely cytosolic. I therefore believe that this part can be omitted from the paper without compromising the rest of the work reported in the other sections.

2\) The parts that discuss the post-translational interaction of the EMC with its clients need to be written with more caution since there is insufficient information about this in the work reported, except for a few full-length protein clients identified in Figure 1A.

Reviewer \#3:

This study addresses an important question related to multipass membrane protein maturation and quality control in the ER. Although it has been previously shown that the EMC complexes interact with such proteins, the mechanisms and detailed functions have


types, however this will require further examination in future studies.

To clarify this point for the reader, we have added the following sentence to the Discussion:

"While our studies in HeLa cells primarily identified solute carriers and transmembrane ATPases as clients, the EMC was previously implicated in the biogenesis of cell-type specific multimeric channel proteins that also contain TMDs with charged residues (Richard et al., 2013)."

[^1]: Department of Molecular Biology, Princeton University, Princeton, United States.

[^2]: Calico Life Sciences LLC, San Francisco, United States.

[^3]: These authors contributed equally to this work.
increase the bandwidth of the search engine and reduce its power consumption.
Despite the advances that have been made in semiconductor contact formation and interconnection, there is still a need for improvements in order to minimize the size of semiconductor chips, while enhancing electrical interconnection reliability. These attributes of the present invention are achieved by the construction of the microelectronic packages as described hereinafter.


We may decide to execute a function not right now, but at a certain time later. That’s called “scheduling a call”.

There are two methods for it:

setTimeout allows us to run a function once after the interval of time.

allows us to run a function once after the interval of time. setInterval allows us to run a function repeatedly, starting after the interval of time, then repeating continuously at that interval.

These methods are not a part of JavaScript specification. But most environments have the internal scheduler and provide these methods. In particular, they are supported in all browsers and Node.js.

The syntax:

let timerId = setTimeout(func|code, [delay], [arg1], [arg2], ...)

Parameters:

func|code Function or a string of code to execute. Usually, that’s a function. For historical reasons, a string of code can be passed,happen without a pause at all.

And here is the picture for the nested setTimeout :

The nested setTimeout guarantees the fixed delay (here 100ms).

That’s because a new call is planned at the end of the previous one.

Garbage collection and setInterval/setTimeout callback When a function is passed in setInterval/setTimeout , an internal reference is created to it and saved in the scheduler. It prevents the function from being garbage collected, even if there are no other references to it. // the function stays in memory until the scheduler calls it setTimeout(function() {...}, 100); For setInterval the function stays in memory until clearInterval is called. There’s a side-effect. A function references the outer lexical environment, so, while it lives, outer variables live too. They may take much more memory than the


an A-list art team, and this exclusive preview of Hawkman: Found #1 shows how pairing Hitch with the legendary inker like Nowlan brings out the meticulous detail of the pencils with smooth, confident lines and delicate shading.

Since leaving DC, Jeff Lemire has played in the Marvel and Valiant sandboxes while also building his own superhero universe in the pages of Black Hammer, this year’s Eisner Award winner for Best New Series, and he’s at his best when he has creative freedom. Over at Marvel, Lemire did some strong work on Moon Knight and All-New Hawkeye, but was buried under editorial restrictions for Extraordinary X-Men, a book completely devoid of passion. Hopefully DC will give him plenty of room to bring his distinct point of view to his newTwo Democratic legislators and immigration lawyers escorted a group of Central American caravan migrants in Tijuana past U.S. guards and through border gates on Monday evening.

The group of favored migrants at the Otay Mesa port of entry included Maria Meza, the Central American woman who was photographed when she brought her two children right up to the U.S. border as border officers launched tear gas to repel aggressive migrants. The group also included several teenagers who will soon turn 18 and lose the legal protections set for non-adult migrants.

“After 7hrs, I can now confirm: Maria Meza & her kids — featured in this @ Reuters image fleeing tear gas at the border last month — just filed for asylum,” tweeted California Democratic Rep. Jimmy Gonzalez. “They’re on American


from the iconic photo, and 7 children who are at risk of aging out of protections because the Trump administration is forcing them to stay in Tijuana past their 18th birthdays. When we got to the border, @ CBP officials did not let us pass. There was zero transparency and their reasons kept changing. Deserving refugees didn’t even have a chance at safety. The Trump administration created this crisis by deliberately stalling border processing and forcing refugees into a months-long wait to request asylum, placing their safety and lives at

Asylum laws do not allow economic migrants to get green cards and then jobs, so most will be rejected by immigration judges.

It is not clear if any of the migrants will be released into the United States or beand divert education spending away from American kids.

Five million Central Americans want to migrate into the United States, according to a Gallup survey published mid-November.:

In Gallup’s most recent global estimate, between 2015 and 2017, 15% of the world’s adults — more than 750 million people — said they would like to move to another country permanently if they could. In Central America, this percentage is one in three (33%), or about 10 million adults. Three percent of the world’s adults — or nearly 160 million people — say they would like to move to the U.S. This includes 16% of adults from Honduras, Nicaragua, Guatemala, El Salvador, Panama and Costa Rica, which translates into nearly 5 million people.

The two legislators from California, Gomez and Rep. Nanette Barragan, posted


get the clip of Fortress going on a bus-ride to wales, if he died and was never able to upload it to Youtube?

Maybe he uploaded it through a mobile device, but it seems to be done with a hand-held camera; so it seems unlikely that he could submit it to youtube mid-wales trip.

The very fact that this youtube video was uploaded suggests that Fortress made it back safely to London to upload the clip, meaning he was not murdered. Plus, if this video had only 24 views, how did the filmmaker find it himself?

Camera straps are usually on the right hand side. Someone who is consciously trying to keep a camera pointed somewhere would probably use their left hand to do whatever and their right hand to keepCigar Assessor

Tuesday, March 4, 2014

On this day, I decided to try a review in my car while I drove around for my job. I set up my new iPhone 5C in my dashboard holder and used my HTC ONE to snap the pictures of the cigar. The cigar I reviewed is the VegaFina Sumum Edicion Especial 2010. This cigar was sent to me from Altadis.

This cigar is well constructed, minimally veined, chocolate brown stick. I smelled sweet chocolate from the foot and earthy, dog and barnyard scent from the stick. I clipped the cap with my Tonino Lamborghini Le Mans cutter and got a nice clean cut as usual. I took a nice open draw of leaves and earthiness. I toasted the foot with my Tonino Lamborghini Black


out candy to the parade watchers.

This group won Best Float!!!!

The next float was entered by the local Moose Lodge and it took the Grand Prize.

I don’t know who entered the next float but I do like its message!

Because there were 48 entries in this year’s parade and a parade is slow moving, one may wonder where the end of the parade is. That wasn’t a problem today. A local bakery company had one of its tractor trailers in the parade and it carried this message.

We didn’t stay to go to the carnival area of the celebration. It was too darn chilly.

So there you have it……

We attended a dance with a country theme tonight. The Activities Department did a great job with the decorating.

Here’s Sandy, our friend and thePat W. accompanied by Arlee sang a funny song about three old ladies who all decided to use the same lavatory stall and they get locked in.

Ahhhh,,,,”Mugsy” Maguire, the wild Irish boy, was next. Frank tickled the ivories for us and sang some beautiful Irish songs. It is always a joy to listen to Frank play.

We had a session of “Musical Humor” next and once again we were rolling in the aisles. Bill Turner, along with his lovely wife Pat, and Arlee all played guitars and Bill sang songs like Kiss my……… Ex. (For those who know him, take a look at that gut! That is NOT Bill!)

One more person got into the act when Bill sang a song about rating a date he had on a scale


of one to ten. Well, Deanna came out and she had her own ratings to give right back to him.

Deanna had her own idea of a “10”. When we saw the “10” on the back of his shirt I thought the roof was going to be lifted off the building with our laughter.

Oh yeah,,,,our man Dale! He’s our 10! We all just love Dale!

Another shot of Deanna. She really seemed to have fun with this.

After a fifteen minute break to stretch our legs and get our butts off those hard metal chairs, have a chance to go buy some popcorn, a soda or an ice cream float, we settled back in for the rest of the show.

The second half started out with Al Howard playing the bag pipeson the stage. The final act was announced….welcome to the stage….Jo Ho & the Hoettes. The music started and then they entered. The audience roared. I had a hard time keeping the camera steady because I was laughing so hard.

They danced to Don Ho’s Tiny Bubbles. NONE of them are hula dancers! NONE! Not even one!

Someone even made a buck!

Oh yeah,,,the Baggies? The rubber boat was used to camouflage a bubble machine to go with the song and we were asked to catch the bubbles and put them in the Baggie so the soap could be recycled.

What a great show! So many laughs. A big THANK YOU to all the participants, you gave us a great night!

Wise Words

There comes a point in your life when you realize: Who


and that together we could be active in politics and try to solve them".

VOLT is a pan-European movement that wants to change the way national politics deals with the main issues for Europeans. One above all: the consequences of the economic crisis, that left a profound mark in the society.

"We are angry but want to find solutions"

Andrea Venzon comes from Italy, a country where the populist government has faced an unprecedented spat with Brussels over its budget plan and the unsolved issue of migration. The anger that pervades the country is understandable, he says, but the government is not addressing the problem at its roots.

“We are deadly angry and we know that we have to find solutions, for example producing growth and producing jobs. It is something completelyQ:

Count number of occurrences for each unique value

Basically I have a table similar to this:
time.....activities.....length
13:00........3.............1
13:15........2.............2
13:00........3.............2
13:30........1.............1
13:45........2.............3
13:15........5.............1
13:45........1.............3
13:15........3.............1
13:45........3.............2
13:45........1.............1
13:15........3.............3

A couple of notes:

Activities can be between 1 and 5
Length can be between 1 and 3

The query should return:
time........count
13:00.........2
13:15.........2
13:30.........0
13:45.........1

Basically for each unique time I want a count of the number of rows where the activities value is 3.
So then I can say:
At 13:00 there were X amount of activity 3s.
At 13:45 there were Y amount of activity 3s.

Then I want a count for activity 1s,2s,4s and 5s. so I can plot the distribution for each unique time.

A:

Yes, you can


activities = 4 then 1 end), 0) as count4,
    coalesce(count(case when activities = 5 then 1 end), 0) as count5
from MyTable
group by time

The advantage of this over grouping by activities, is that it will return a count of 0 even if there are no activites of that type for that time segment.
Of course, this will not return rows for time segments with no activities of any type. If you need that, you'll need to use a left join with table that lists all the possible time segments.

A:

If i am understanding your question, would this work? (you will have to replace with your actual column and table names)
SELECT time_col, COUNT(time_col) As Count
FROM time_table
GROUP BY time_col
WHERE activity_col = 3

1. You can’t turn off the government radio installed in your home, only reduce the volume.

2. Idolatry in North Korea is such that it is second-nature for ordinary citizens to “rescue” portraits of Kim Il Sung before all else in the case of a house fire (there are even special bunkers for statues in case of war)

3. Many people don’t even know that man has walked on the moon.

4. There is no Internet, cell-phones have been banned.

5. A main cause for all problems are Americans. Mothers teach their children to sing songs about bad Americans, there are many postage stamps showing the death of “U.S imperialists”

6. A six-day work week, and another day of enforced “volunteer” work, ensures that the average citizen has virtually no free time.

7. The


available at an extra charge. Window casings are 2¾ inches wide instead of 3½ inches wide in one scaled-down model that Wieland is just now putting on the market. In another, company officials want to move a master-bedroom window from the side wall of the house to the rear. Smaller houses come on smaller lots, and having a window on the side makes it hard to avoid noticing that the neighbor’s house is just a few yards away.

The other day, Mr. Kingsfield, the company’s sales chief, pulled into a golf-club development near Canton, Ga., and stopped at a lot where workers were listening to mariachi music as they stacked bricks to form the facade of a 3,335-square-foot home called the Madison.

A couple of years ago, a new housein this neighborhood would likely have had a two-story foyer that framed the curved staircase inside. But the Madison’s staircase is neither grand nor visible from the front door. In fact, it climbs out of the mud room next to the garage.

“In an ego-driven market, it’s where you walk in the door and impress friends with the staircase,” Mr. Kingsfield said. “That’s gone. It’s not about impressing anymore. It’ll still be nice. There will still be wood, still be trim. But it’s more conservative.”

I had to wear gloves and a balaclava on my ride to work this morning, and now there’s snow falling outside. It seems appropriate, then, that we’re mailing in our application for federal weatherization funding tomorrow. Thanks for the blown-in wall insulation, President Obama!

To Shane


(in the comments): You’re right, although technically I owe more thanks to (1) China, for extending us more credit, and (2) my daughter, for taking on the investment.package com.onarandombox.MultiverseCore.utils;

import com.dumptruckman.minecraft.util.Logging;
import net.milkbowl.vault.economy.Economy;
import org.bukkit.Bukkit;
import org.bukkit.event.EventHandler;
import org.bukkit.event.Listener;
import org.bukkit.event.server.PluginDisableEvent;
import org.bukkit.event.server.PluginEnableEvent;
import org.bukkit.plugin.Plugin;
import org.bukkit.plugin.RegisteredServiceProvider;

/**
 * A class we use to interface with Vault when it is present.
 */
public class VaultHandler implements Listener {

    private Economy economy;

    public VaultHandler(final Plugin plugin) {
        Bukkit.getPluginManager().registerEvents(new VaultListener(), plugin);
        setupVaultEconomy();
    }

    private boolean setupVaultEconomy() {
        if (Bukkit.getPluginManager().getPlugin("Vault") != null) {
            final RegisteredServiceProvider<Economy> economyProvider =
                    Bukkit.getServicesManager().getRegistration(net.milkbowl.vault.economy.Economy.class);


Logging.finer("Vault was not found.");
            economy = null;
        }

        return (economy != null);
    }

    /**
     * Listens for Vault plugin events.
     */
    private class VaultListener implements Listener {
        @EventHandler
        private void vaultEnabled(PluginEnableEvent event) {
            if (event.getPlugin() != null && event.getPlugin().getName().equals("Vault")) {
                setupVaultEconomy();
           }
        }

        @EventHandler
        private void vaultDisabled(PluginDisableEvent event) {
            if (event.getPlugin() != null && event.getPlugin().getName().equals("Vault")) {
                Logging.fine("Vault economy disabled");
                economy = null;
            }
        }
    }

    /**
     * Checks whether Vault is in use


not really sold on this as a default behavior, but we may add an option for this. There are a few other cool things related to this also in the works…

– Log-in screen keeps users from perceiving the app as non-responsive while it logs in and gets ready. We’ll look into ways to accelerate start-up.

– We will investigate an alternative to “scroll to where you were” in the queue

– MOG iPad app
Despite the relatively low penetration of this device, we’re working on one. No more details on this until it gets closer to release, though.

– Artist Bios and Album Reviews coming in next major update

– There will be a fancier/more complicated “options” button for items rather than just a download button.

Leave Comment

Looking for the best iPhone, iPad &Q:

Conditional Variance

I'm having a bit of trouble conceptualising the step which i have highlighted.

A:

Recall the variance of the sum of independent random variables:
$$
    \mathbf{Var}(Y_1+Y_2 + \cdots + Y_n) =  \mathbf{Var}(Y_1)+\mathbf{Var}(Y_2) + \cdots + \mathbf{Var}(Y_n)
$$
Now is these independent random variables are identically distributed, $ \mathbf{Var}(Y_1)=  \mathbf{Var}(Y_2) = \ldots =  \mathbf{Var}(Y_n) = \sigma^2$.
The conditional variance $\mathbf{Var}\left(\sum_{i=1}^X Y_i \mid X\right)$ means variance of the sum for a fixed values of $X$, making the above calculation immediately applicable.


combination of factors; main-sequence OB stars, evolved [H[ii]{}]{} regions, significant remaining molecular gas and dust, and ongoing steady star formation, all make this region ideal for studying feedback and the properties of pillars.

Here we present high resolution ($\sim 5$) observations of the large scale CO emission towards a pillar in the Vulpecula rift [Vulp3 using the terminology of @Billot2010] 16 pc from the ionizing source. Below, in Section \[sec:obs\] we present our CARMA and FCRAO observations and how they were combined, and in Section \[sec:results\] we present our observational results. In Section \[sec:discussion\] we discuss the implications of these results in terms of the physical processes at work around and within the pillar, as well as comparing our results to the quantifiable predictions from some of the modelsmolecular weight (as $m_p$ is the mass of a proton). From this equation we find a gas mass of 91 M$_\odot$.

We note that for the portion of the pillar observed with CARMA, the dust temperatures and column densities are consistent [along the long axis]{} of the pillar, suggesting that there is no difference in the pillar irradiation between the sides closer and further from the ionizing source. This may be due to the low resolution of our temperature and column density maps, which are limited by the resolution of the 500$\mu$m Herschel dust map of the region (36.5$''$).

\[sec:protostar\]

From the 70$\mu$m emission map of this region, there appears to be an embedded core within our pillar. It does not appear in any of the shorter wavelength observations of MIPSGAL


line of sight), as each side of the pillar is undergoing collapse. Barring the double peak seen in our [$^{12}$]{}CO emission, which is likely an optical depth effect, we only see single peaked profiles in the [$^{13}$]{}CO and C[$^{18}$]{}O emission in the observed pillar (See Figure \[fig:layer\_spectrum\]). This suggests that our pillar is not collapsing in on itself, and may be older than the pillars probed in their work.

From the column density in the pillar, and the assumption that the pillar is cylindrical, we derive a gas volume density of 8$\times10^{3}$ cm$^{-3}$. This comes from the gas column density derived from both the gas and dust, which are consistent with each other. Further using the average temperature of 18.2 K within the pillar (see Section \[sec:dust\]), we findthose determined observationally. We note that we may be seeing pillar motion, but it is unclear whether we observed internal flows of gas within the pillar.

@Dale12a [@Dale12b; @Dale13a] and [@Dale13b] modelled the propagation of ionizing radiation from O–stars from [*inside*]{} turbulent molecular clouds to examine the impact of feedback on the cloud structure and dynamics, and on the ongoing star formation process within the clouds. The simulated clouds have a filamentary structure generated by the interaction of turbulent flows. Gas flows along the filaments, so they are also accretion flows. The most massive clusters and stars therefore tend to form at filament junctions. Ionization feedback in these simulations often produces prominent bubbles on scales up to a few $\times10$pc. In several of the @Dale12a calculations, most prominently their


Q:

How to save data on wear os android in standalone app

Hi on android apps I used onSaveInstanceState to persist my data when I rotate the phone or exit app. Now I'm making Wear Os for smartwatch app that will be stand-alone but will be also able to connect to my app on the phone. So I manage to connect a phone and wear app with DataClient but my problem is when I start the app on the watch, get some score and then exit the app by swiping from left to right my app my score is reset to zero. Interesting is that the score is saved if I exit the app with the power button but I don't think that has to do anything with my onSaveInstanceState.
Itried to use onSaveInstanceState in wear app but it does not work. When I tried to debug it is not called. I guess it is not supported to work on wear and that I have to, somehow, use DataClient API for this but I don't know how to use it for this purpose. This is all new to me and I'm still a beginner. I only manage to send images from a phone app to wear app but I want to be able to save data without phone connected and to retrieve it.
I just want to save data from my UI so when a user comes back to my app that data is not lost. So need some simple sample code like saving some int or string and


president of the American Psychological Association

Notable faculty

Arts

 Emma Amos — professor of fine arts; postmodernist painter and printmaker; member of Spiral; editorial board member of feminist journal Heresies; member of Fantastic Women in the Arts
 Julianne Baird — professor of music (Camden), soprano
 Vivian E. Browne — painter, professor of art
 Angelin Chang — former associate professor of music; Grammy Award-winning classical pianist
 Leon Golub — professor of fine arts
 Al Hansen — professor of finer arts; a founder of Fluxus
 Allan Kaprow — professor of fine arts
 Roy Lichtenstein — professor of fine arts
 Robert Moevs — professor of music
 George Segal — professor of fine arts; Fluxus artist
 Robert Watts — professor of fine arts
 Charles Wuorinen — professor of music; Pulitzer Prize–winning composer anddynamic as always, Yoga Festival|Milan is getting ready to welcome its old and new followers with an unique program thought to walk them through the endless shades Yoga has acquired in its long life. FESTIVAL MAIN THEME The change is in the air, it’s coming, the transformation is already knocking on the door.We don’t know what there is in the cards for us, life and history are so unpredictable and there are no guaranties. Nevertheless we can get ourselves ready in the best way possible by practicing Yoga. Meditation, nutrition, nursering of the body and of the mind. With the practice everything can fall into place, find the harmony.

THE PROGRAM
This year program aims to give many opportunities and stimulus to start or deepen the path towards the change.


Buchberg, Mecklenburg-Vorpommern

Buchberg is a village and a former municipality in the Ludwigslust-Parchim district, in Mecklenburg-Vorpommern, Germany. Since 25 May 2014, it is part of the municipality Ganzlin.

References

Category:Ludwigslust-Parchim
Category:Former municipalities in Mecklenburg-VorpommernIsolates of Neisseria meningitidis from different sites in the same patient: phenotypic and genomic studies, with special reference to adherence, piliation, and DNA restriction endonuclease pattern.
Neisseria meningitidis was isolated from the throat, blood, and cerebrospinal fluid of six patients and from the throat and blood of two patients. All 22 isolates were of serogroup B, serotype 15, and sodium dodecyl sulfate-polyacrylamide gel electrophoresis type IV. Isolates from a single patient always possessed identical DNA restriction endonuclease patterns; this observation strongly suggested genomic identity. In spite of this apparent genomic identity, however, significant differences in piliation and adherence were observed among isolates from different sites in the same patient. Isolates from the throat were significantly more piliated (P less than .001) and adhered to human buccal epithelial cells in


interest, half out of worry that the first North animal that saw him would finish him off. But over the next two hours a procession of North-clan hyenas wandered past Dolittle during their morning perambulations, and none of them seemed terribly concerned with the invader. High-ranked Joni gave him an idle sniff – he answered with an intensely submissive posture and she went on her way, trailing young Hooker who barely looked at Dolittle. Later a mixed-sex group of young adults – Leprechaun (m), Arrow (f) and Peepers (f) – thought he was interesting enough to check out from a distance of about 30 meters. Dolittle heaved himself up from his convalescent nap and trotted another 20 meters away, and the three North-ers headed casually in the oppositeTag Info

It can be argued that the interior of many Christian Churches, especially Catholic, Orthodox, Anglican, and Lutheran, lies in the architecture specified for the Tabernacle (The tent constructed during the Exodus) and the Temple in the old textament, where there were three area set aside for specific purposes. The area where the Altar is located in the ...


such as geocharts and gauges, and it also includes built-in animation and user interaction controls.

NVD3: Is a library meant for reuse. The project takes all the power of D3 and distills them down into common chart types. I really like this idea because it gives you constrains and prevents you from running wild with different designs, while at the same time making the code much easier and more approachable if you are just getting started in data visualization.

TABLEAU: Places great emphasis on the ability to create visualizations without the need for any technical skills (scripting). and has a relatively easy to use interface. As with other products of this nature its utility is firmly anchored in visual exploration of data using every format imaginable. It is not aThis Blog is for all people working or related to the MSI and App-V.
There are lots of issues we face in everyday work regarding the technology. The sole purpose of my blog is to help others with whatever I learn. All you people out there, please help by commenting, voting, propagating and sharing my blog with your friends and colleagues but with due credit and acknowledgement to the material posted here with my name and blog url as I still do hold the copyright of the posts here.

Sunday, March 18, 2012

VBScript to Kill a Process

This worked great for me. Just use as function and kill as many processes as you like.


offer of staying" " at my current job " " Working for you dad." "Exactly!" "And I could never leave grandpa, so I am going to say "no" to the first offer " "Only offer." "Even though I would have made an excellent" "Regional Vice President in charge of promotions." "She is great at promotion." "That title gets longer every time I hear it." "Come on, don't go to school." "Girls' day!" "We'll swing by the mall." "You could use a new everything." "Girls, get in the car." "Luke's hurt." " Oh, my god." " What happened?" "He collapsed on the way to school." "He's in the hospital." "Come on." "What's wrong with Luke?" "Why'd he collapsed?" "[ Seat belts click ] I heard he was dead!" "["You cut yourself." "Hey!" "Don't get blood in my eggs." "[ Sighs ]" "We're getting concerned that Lily hasn't developed an adequate sense of empathy." "Insofar as she doesn't have any at all." "[ Whirring ] Okay, that's good." "I can feel that working." "I know." "I can finally breathe." "[ Sighs heavily ]" "I can't hear myself think!" "[ Plug thuds, whirring stops ]" "Nice preview of our sunset years." "She literally pulled the plug on us." "Claire:" "I wasn't gonna mention the other job offer to my dad, but I didn't want him just hearing about it, so after wrestling with it all day, I decided to tell him." "Hey, you're in early." "Are you ready to have a laugh?" " Janice's haircut?" " Ugh." "Give


time." "You know what?" "You're right." "Let's do you." "Your problem is bigger than mine anyway, 'cause if your plan is to cry in front of Lily..." "[ Whispers ] Forget it." "You're too emotionally constipated." "You know, i-i know you're joking, Claire, but sometimes..." "Sometimes words hurt, you know?" "And to think that my own sister..." "[ Voice breaks ] My own sister would accuse me of -- [ normal voice ] Oh, screw it." "I'll just work up some tears with a sad movie." "It's fine." " Mom?" " Ah!" "You're awake." "How you feeling?" "Aw." "You bought me a balloon." "What?" "And a Teddy bear." "When did you buy all this stuff?" "Uh..." "When -- When you were asleep and I got you a strawberrymilkshake." "Mom, you're the best." "He couldn't remember a thing." "All I had to do was to get him past the 5:00 deadline so that he couldn't go on that trip with Kylie." "I know what happens at camp." "I've seen "Meatballs."" "I still can't believe Kylie flaked on me." "I thought she really liked me." "I guess not." "Time for more pills, baby." "Really?" "I'm already so loopy." "We have to get ahead of the pain." "Maybe she texted me." "Have you seen my phone?" "Is it over there?" "I don't see it." "What are you doing?" "Eh..." "Hugging!" "You're so sweet." "But I don't think these pills are really doing anything." "[ Grunts ]" "Does this place look familiar?" "Alex:" "Oh, yeah." "This is where we


we're not actually caged in together." "I'll be calling you all the time. [ Scoffs ]" "Think about it " " I'm about to live on a campus full of Alexes." "That's bound to get annoying." "And when it does, who better to deal with an Alex than you?" "I made that." "Hey, you wanted to see me?" " Just got off the phone with Dan Signer." " Who?" " He's one of the big mucks at the Grand Royal Hotels." " Oh." "They're thinking about dropping our account." "Something about you turning down the job offer." " Well..." " And then accepting it, and then turning it down, and then accepting it again." "Why are you jerking him around?" "You're worse than Claudia." " Who's Claudia?" "import Vue from 'vue'
import App from './App.vue'
import router from './router'
import store from './store'
import Storage from 'vue-ls'
import 'lib-flexible/flexible'
import 'view-design/dist/styles/iview.css'
import VueLazyLoad from 'vue-lazyload'
import mavonEditor from 'mavon-editor'
import 'mavon-editor/dist/css/index.css'

import {
  Input,
  Icon,
  Button,
  Drawer,
  Avatar,
  Page,
  BackTop,
  Form,
  FormItem,
  Message,
  Modal
} from 'view-design'

Vue.component('Input', Input)
Vue.component('Icon', Icon)
Vue.component('Button', Button)
Vue.component('Drawer', Drawer)
Vue.component('Avatar', Avatar)
Vue.component('Page', Page)
Vue.component('BackTop', BackTop)
Vue.component('Form', Form)
Vue.component('FormItem', FormItem)
Vue.component('Modal', Modal)

Vue.use(VueLazyLoad, {
  error: require('./assets/images/logo.png'),
  loading: require('./assets/images/logo.png')
})

Vue.use(mavonEditor)

Vue.prototype.$Message = Message
Vue.config.productionTip = false

Vue.use(Storage, {
  namespace: 'boblog__',
  name: 'ls',
  storage: 'local'
})

router.beforeEach(async (to, from, next) => {
  store.commit('headers/SET_NAV_INDEX', to.meta.navIndex)
  next()
})

new Vue({
  router,
  store,
  render: h => h(App)
}).$mount('#app')


Q:

what does "TERM environment variable not set" mean?

I was writing a simple console application in Objective C.
I have tried system("clear") but I am getting this message on console
"TERM environment variable not set."
Can anyone explain me what this is all about ?
I am very new to both OSX and Objective C.
and I am sorry if this question is too dumb as I have not programmed much on *nix.
(I have been doing a lot of Java and PHP development in my college days).

A:

The TERM environment variable tells your program what type of terminal its running on. Each type of terminal displays data and responds to commands in its own way. For example, a VT100 terminal works quite differently from a IBM 3270 terminal.
The error message you're seeing saysto apoptosis. Large-scale gene expression analysis revealed that T(FH) cells are only distantly related to CXCR5(-) and CXCR5(+) central memory T (T(CM)) as well as effector memory T (T(EM)) cells present in the periphery. CXCR5(hi)ICOS(hi) CD4 T cells appear to be terminally differentiated T helper cells that express a unique set of transcription factors related to the Notch signaling pathway and thus differentiate independent of other T helper cell populations.


easily generates a braking force depending on the amount of brake operation, in a range in which the amount of brake operation is small, including in the range just after the start of operation. As a result, the perceived feeling during braking is improved.
For vehicles such as motorcycles, there has been an electronic braking device in which a pressure sensor electrically detects a working fluid pressure corresponding to the amount of operation of a brake lever, brake pedal or the like, and according to the result of detection, an electric actuator actuates a hydraulic modulator to produce a fluid pressure and apply this fluid pressure to a brake caliper, thereby obtaining a braking force on wheels. This type of electronic braking device is disclosed, for example, in JP-Adatasets.

A:

I think you want scipy.stats.percentileofscore
Example:
percentileofscore([1, 2, 3, 4], 3)
75.0
percentiles = [percentileofscore(data, i) for i in data]

A:

Pure numpy version of Kevin's solution
As Kevin said, optimal solution works in O(n log(n)) time. Here is fast version of his code in numpy, which works almost the same time as stats.rankdata:
percentiles = numpy.argsort(numpy.argsort(array)) * 100. / (len(array) - 1)

PS. This is one if my favourite tricks in numpy.


accountable, rather than being unelected bureaucrats.

Instead, the sentence ‘the EU is governed by unelected bureaucrats’ is directed at the role of the Commission. The Commission is composed of a bureaucracy or administration, divided into Directorates-General (DGs), run by civil servants, and a ‘government’, the College of Commissioners, where each member state nominates a commissioner that has to be approved by the European Parliament. However, although it is technically true to call one part of the Commission, the civil servants, ‘unelected bureaucrats’, the expression equally applies to national civil servants, which also happen to be ’unelected bureaucrats’. Every government has bureaucrats which are by nature unelected. While the EU has around 33,000 of them, the British government employs over 400,000 civil servants. In addition, there is the complaint ‘thatthe couplings, they freeze into the spin glass state for $T<T_{SG}$ [@Mydosh:1993]. In the spin glass state, the frozen spins act on the conduction electrons just like a classical random magnetic field. In the rest of the letter, we will focus on this regime ($T_{SG} >T \gg T_{K}$) where transport properties simply result from coherent diffusion of electrons by both a classical random magnetic field and the associated scalar potential.

Let us start by recalling known results about the fluctuations of conductance induced by a scalar random potential $V({\bf r})$. We denote by $L_{\phi}$ the dephasing or inelastic scattering length, which is considered larger than the sample size $L$ (mesoscopic regime). The associated inelastic scattering rate is $\gamma_{\phi} = \hbar / (2 \tau_{\phi})= D \hbar /(2 L_{\phi}^2)$, D being


glass state, and their slow evolution.

Let us end by commenting on the dimensionality of a mesoscopic spin glass. To remain in the coherent transport regime, sample size $L$ has to be of the order of (or lower than) the inelastic coherence length $L_{\phi}$ [@footnote:L-phi] Often quantum diffusion takes place in an effective space of dimension $D=1$. On the other hand, the dimensionality of the spin glass is determined by the dynamical correlation length. Values of the correlation length $\xi_{SG}=N_{SG}. n_{imp}^{1/3}$ ($n_{imp}$ the density of spins) extracted from field change experiments for various spin glasses [@Bert:2004] and extrapolation from recent numerical simulations [@Jimenez:2005] are of the order of $N_{SG} \sim 30-50$ spins after a waiting time $t_{w}=1000 s$. For samples with transverse dimensions $L_{y},L_{z}$ larger than $\xi_{SG}$, the proposedand drop a defensive lineman back into coverage. This takes away shallow crossing patterns and allows the linebackers to fan a little wider to better defend the flats. Shallow crosses and the flats are where Edelman (and much of New England’s passing attack) lives. The Seahawks did this with great success against the Broncos last year.

4) The ground battle

The other part of making Brady beat you is taking away the Patriots’ power running game. It racked up 177 yards against an undersized Colts front seven that couldn’t prevent offensive linemen from working up to the linebackers in the AFC title game. The Seahawks don’t have the biggest D-line. At linebacker, weighing in the mid 240s, Bobby Wagner and K.J. Wright both have better size than Indy’s D’Qwell Jackson


An Internal Revenue Service report noted that roughly 1.4 million illegal aliens are working and paying taxes using stolen Social Security numbers. It also noted that the IRS isn't the best at catching this fraud. either To make things more maddening, they’re not allowed to work with the Department of Homeland Security on finding the identities of people using Individual Taxpayer Identification Numbers, which are doled out to immigrants that are not authorized to work in the U.S, according to Stephen Dinan at The Washington Times had more:

Most illegal immigrants who pay taxes have stolen someone else’s legal identity, and the IRS doesn’t do a very good job of letting those American citizens and legal immigrants know they’re being impersonated, the tax agency’s inspector general said in aQ:

I need to install i tar.gz file, but nothing on here helped

Look. I have looked everywhere for the answer but I cant find it, so here goes. i need to install a tar.gz file. Ok, ok, yes I am a beginner , but I really need help. I want to install prisonarchitect-alpha26b-linux.tar.gz. the file directory is /home/rhys/Downloads/prisonarchitect-alpha26b-linux.tar.gz. and I am running ubuntu version 14.04 32bit. PLEASE HELP!

A:

Are you sure you need to install it? Try just extracting the file and look for executables (things that you can run).


\[[@CR7]\] were able to probe for links between disease and isoform specificity; for example, they observed an isoform switch in circZDBF2 from a 447-nucleotide (nt) isoform in normal liver tissues to a 334-nt isoform in liver cancer, providing a candidate for future functional and/or biomarker analysis. CIRI-full promotes the accurate quantification, differential analysis, and alternative splicing analysis of circRNA transcripts and will greatly improve our understanding of circRNA at up to isoform-level resolution.

Functional characterization of circRNAs {#Sec5}
=======================================

Current analyses indicate that perturbation of circRNAs is widespread in human cancers \[[@CR1]\]*.* One of the best-known circular RNAs, CDR1as, has been shown to promote (by acting as a sponge for miR-7) the upregulation of oncogenic factors (such as CCNE1 and PIK3CD) that are targeted by miR-7, thus regulating the proliferation ofcell type in pleural fluid, are shown in [Table 1](#pone.0165428.t001){ref-type="table"}. Although there were no significant differences in presenting symptoms between the two groups, inflammatory serum markers, such as white blood cell (WBC) count (*P* = 0.001) and C-reactive protein (CRP) (*P* = 0.001), were higher with neutrophil-predominant pleural TB than with lymphocyte-predominant pleural TB. A chest CT was performed in 173 patients (86.5%) during the diagnostic workup, and there were no significant differences in pulmonary parenchymal lesions indicative of TB, on chest CT or X-ray, between the two groups.

10.1371/journal.pone.0165428.t001

###### Baseline Characteristics of 200 Patients with Pleural TB.

![](pone.0165428.t001){#pone.0165428.t001g}


subtypes (hormone-receptor positive, HER2 positive, and triple negative breast cancer) are limited.Added value of this studyHere, we present the results of a large (\>250 patient), clinically annotated cohort of patients with metastatic breast cancer who underwent ctDNA evaluation. We report the mutational frequencies across subtypes and the frequency of clinically meaningful alterations in *PIK3CA, ESR1*, and *ERBB2*. Additionally, there was relatively high agreement between blood and tissue sequencing, and ctDNA content was significantly associated with number of metastatic sites on imaging. These data reinforce the capability of utilising ctDNA to detect tumour heterogeneity across breast cancer subtypes, the high prevalence of clinically actionable alterations, and the association between ctDNA and tumour burden on imaging.Implications of all the available evidencectDNA reflects the tumour landscape in blood to accurately reflect(21.6%), respectively ([Fig. 1](#fig0001){ref-type="fig"}). For the HR+ HER2- cohort, 37 out of 123 (30.1%) patients had *ESR1* mutations. The detection of *ESR1* mutations was significantly associated with prior use of AI (*P*\<0.001). With respect to *ERBB2*, 28 of 55 (50.9%) alterations were amplifications and the remaining 27 of 55 (49.1%) were mutations. For *ERBB2* copy number changes, 27/28 (96.4%) of patients with amplifications occurred in HER2+ patients. Notably, one amplification was observed in a HR+ HER2- patient. In contrast, for mutations in *ERBB2*, 16 were observed in HR+ HER2- (16 of 17 *ERBB2* alterations, 94.1%), 8 were encountered in HER2+ patients (8 of 35 *ERBB2* alterations, 22.9%), and 3 mutations were found in TNBC patients (3 of 3 *ERBB2* alterations, 100%). Importantly, the diversity of alterations detected in


drug resistance to potentially guide clinical management. Potential clinical utility of ctDNA could include an initial assessment of alterations with known drug targets, such as *PIK3CA* and *ERBB2*. In terms of treatment monitoring, a growing body of evidence has identified that changes in specific alterations or tumour burden, as indicated by ctDNA MAF, correlates with treatment response \[[@bib0023],[@bib0037],[@bib0038]\]. This may enable monitoring of specific alterations (e.g. *PIK3CA* changes in response to alpelisib) or changes in MAF in response to systemic therapy. Here, we add additional insight to this literature by associating findings on imaging with ctDNA assessment. Specifically, MAF (e.g. tumour burden) and genomic heterogeneity (e.g. number of alterations) in ctDNA were both significantly associated with increasing number of metastatic sites on imaging. Therefore, in our cohort, ctDNAthe largest clinically annotated datasets. Collectively, our data reinforce the genetic heterogeneity of metastatic breast cancer that can be captured in blood, concordance between blood and tissue NGS, the high prevalence of clinically actionable alterations, and the potential to utilise ctDNA as a surrogate for tumour burden. Further studies are needed to independently validate these findings, to compare dynamics of serial genomic testing of metastatic breast cancer patients in the blood, and to incorporate ctDNA assays into novel clinical trial designs for patient enrolment and stratification.

Funding sources {#sec0018}
===============

Lynn Sage Cancer Research Foundation, OncoSET Precision Medicine Program, and REDCap support was funded in part by a Clinical and Translational Science Award (CTSA) grant from the National Institutes of Health UL1TR001422. The funding sources had no role in the study


Shop

Curl Elixir

No flaking, no crunchy curls; just moisture and great curl definition! The Best Wash n’ Go Hair product.

Made with:

Flaxseed Gel

Vegetable Glycerin

Honey

Phenoxyethanol (and) Caprylyl Glycol (and) Sorbic Acid (Preservative)

Lavender Oil

Product is 4 oz (gel is heavy, a little goes a long way)

Potential Allergens
Our products may contain tree nuts (shea/coconut) and do have ingredients that may have been produced in a factory with wheat, egg or milk products, please keep this in mind when purchasing.

Additional information

7 reviews for Curl Elixir

When I say this stuff is the bomb!! I mean the bomb!!! My hair was so moisturized and defined.

Rated 5 out of 5

Pamela Walker (verified owner)–August 4, 2018

Did not feel a product buildup with the flaxseed gel. The flaxseed gel defined my short curls. I did use a leave-in conditionwith my hair type and hunty. This Curl Elixir by Reclaim your Crown showed up and showed out. I tried it as soon as I got it on my freshly washed hair and finger coiled and my curls were on lock not hard no flaking just silky to the touch, moisturized but not greasy , not dry just fabulousness. I plan to order more of this and the coconut milk to see what that does to my crown. I give it 5 stars. Up side is I got to try it for the price of s/h. Get you some and thank me later.

Rated 3 out of 5

Ruth (verified owner)–July 8, 2018

Ordered trial size. Received and product is a liquid. Maybe temperature was too hot. Unable to get full


said Smith calls him on the phone after games to review and critique his performance hours after its conclusion. They quickly get the “I love yous” out of the way first before breaking down Smith’s latest outing. Following the title game, he met Smith at the team hotel to congratulate him.

“I’m like, ‘Man, you caught the game-winning touchdown.’ And he was like, ‘I could’ve done this in the game. I could’ve done this better.’ He’s critiquing himself,” Sanders told BamaOnLine. “Once again, that’s Tay Tay. He’s always thinking of, ‘What could I have done better? Yeah, we won, but if I had been doing this earlier or doing this better -- I could’ve caught two touchdowns earlier and the game wouldn’t have been close.’ So, he’s that humblethe book, that’s how I look at it. This kid is just a different kid.”

Smith recorded seven receptions for 156 yards and three touchdowns as a true freshman in 2017 as one of three newcomers that came off the bench. With all three starters from last year’s team now gone, Smith, Jerry Jeudy and Henry Ruggs III will be the leading receivers.

During the Crimson Tide’s preseason practices, the former 4-star recruit said he was focused on improving his technique and fundamentals. And an experiment in the spring will certainly help him with that. For a few practices, Smith spent some of UA’s individual periods working with the cornerbacks because of a lack of depth, giving him experience in case of an emergency.

“We’ve done it in the past with


Ask HN: How does your open source project ask for sponsors? - fulldecent
What is a classy way to ask for money for an open source project? I just now realized every project needs a desired outcome. For open source, money is a positive outcome.
I know this project is very small but I want to perfect the classy approach before trying it elsewhere.
----
Sponsorship
\[ YOUR LOGO HERE \]
Please contact xxxxxx to discuss adding your company logo above and supporting this project.
https://github.com/fulldecent/FDSoundActivatedRecorder/blob/master/README.md
----
Is that too much, too little? What other classy approach have you seen on other small to medium sized projects? I'm not talking about Joomla, but rather the millions of projects that HN readers are contributing to.
======
itamarst
YOUR LOGO HERE quickly results in people trying to do SEO optimization with
unrelated ads,the size of the steps grows with the turn-around temperature until $T_{aA}$ is reached. For $T
> T_{aA}$, no appreciable change in the step size is observed. This suggests that only a portion of the liquid in aerogel undergoes the B$\rightarrow$A conversion on warming in that region. An inevitable conclusion is that the A and B phases coexist in that temperature window. Consistent behavior has been observed in 99.3% porosity aerogel, although in the presence of a 284 G magnetic field [@baumgardner]. It is worthwhile to note that at 10 G, the equilibrium A-phase width in bulk below the PCP is $<$ 1 $\mu$K. A quadratic field dependence in the warming A-B transition is observed in our study up to 2 kG. No information on the spatial distribution of the two phases


LOS ANGELES — CBS is yanking the freshman sitcom “We Are Men” from its schedule.

The Monday night comedy about four bachelors starred Tony Shalhoub, Jerry O’Connell, Kal Penn and Chris Smith. But it failed to gain traction with viewers and is now among the new season’s early ratings casualties.

Starting next Monday, “2 Broke Girls” will replace “We Are Men” in the 8:30 p.m. time slot, with repeats of “The Big Bang Theory” airing at 9 p.m. for two weeks.

On Monday, Nov. 4, the sitcom “Mike & Molly” will return for its fourth-season premiere at 9 p.m. The series stars Melissa McCarthy and Pittsburgh comedian Billy Gardell.

o o o

NEW YORK — Comedian and condo board president Joan Rivers is being sued for $15 million in a dispute involving aPlease find the CC tool on the load bar to turn on English captions.As seen by thousands of viewers on Living Intelligence on LA 18 TV, the benefits of using Sae Arc gets demonstrated by Good Samaritan medical director and acupuncturist Dr. Bae. Orie......

At http://bergmanchiropractic.com and http://Owners-Guide.com we strive to educate people on natural solutions to health.SUBSCRIBE at http://www.youtube.com/user/johnbchiroCALL TOLL FREE 1-855-712-0012 to get bonus materials not on YouTube or text yo......

America's FIRST and ONLY daily TV talk show for Filipinos, Kababayan Today, presents the benefits of using Sae Arc stretching devices. Ada Wells, President of ProBalance Inc. who is the educator/mentor at Polestar PIlates International, MPT, and PMA......

*Will be adding Audio list into description soon* I've been on a Yugioh kick lately, and had a ton of


and minimize your risk.

CONSIDERATION 4. Choose a lawyer you trust. More than anything else, your satisfaction in the attorney-client relationship will depend on trust.

CONSIDERATION 6. Choose a lawyer who will take time to answer your questions. You won’t make good decisions if your questions go unanswered.

CONSIDERATION 7. Choose a lawyer who cares about his family, friends, and business community. This attorney has his reputation at stake and is more likely to care about building your reputation too.

CONSIDERATION 8. Choose a lawyer who is a respected source of information — who has dedicated his practice to helping people understand the strategies that will help their business thrive.

CONSIDERATION 9. Choose a lawyer who charges fair fees. If the fee is too low, beware that you might get even worse thanSounds interesting.

Quote:

Original post by BunnzI would suggest C# and XNA since it is easier than C++ and you can run it on both the PC and XBOX.

Honestly I don't really have interest in working with the 360, but I have interest in working on windows, os x, and unix.

Well other than already having a good grasp of C++ for using SDL there isn't many books covering it.Having made 2D games using most 2D api's the list MrCpaw provided is pretty much in order of increasing difficulty and I'll add a couple of my own to the list:

Gamemaker easiest.Then something like Flash is a little harder.Then Python with PyGame with let you made a lot more 2D games with a little more work but you get noticeable speed increase.If


doll to the hilt and even sulked when she lost the game to Akshay. Sallu, unfortunately for him looks utterly besotted by Kats while the latter simply preened and smiled and remained non-committal. Only a miracle would make her marry Salman.

The actor was once again roped in for a quick on the couch session with Koel Purie on Headlines Today. He looked rather funny with his surma laden eyes and heavy eye shadow on the sets of Veer where Koel had met him. Towards the end of the show, it seemed like a rapid-fire session was in progress. One hilarious answer though in response to who he disliked was unwittingly funny. Sallu replied that he didn’t dislike anyone that much for if he did, that person wouldn’t beuncomfortable working with each other.

Kaate ki Takkar, which is the contest following Comedy Circus 2 will not have Vijay and Juhi working together as a couple.ῠ Vijay was apparently angered by Juhi’s habit of being unpunctual and making frequent changes to the script.

Smriti plans Gandhi series

UTV Television which gave India its first Hindi daily soap Shanti has joined hands with Smriti Irani Production for a series on Mahatma Gandhi. The series will be based on the life of Gandhi and his incessant search for Truth. The project is meant for a global audience as discussions with the US and UK broadcasters are underway. This series is Smriti’s idea. “Though Gandhi’s sacrifices have been chronicled on screen before, we would also like to highlight the sacrifices made by his


only about six parallel cinema films” a month.

At times less, coming down to as little as two out of 120 films a month. Interestingly, unreleased entertainers like “Partner” and “No Smoking” with popular stars have already been bought by various channels!

As Filmy’s Ashutosh says, “We don’t have the luxury of waiting to know the film’s box office fate.” The channels are ready to shell out up to Rs.30 crore for a Yash Raj bouquet, but will not stake even a fraction of that for parallel cinema. Even box office duds like “Raja ki Aayegi Barat” (one of Rani Mukherji’s early films) or “Janani” (a Bhagyashri-starrer that was taken off some theatres on the third day of its release) are preferred to classics like “Ankur”, “Bhumika”, “Mrigaya”, “Manthan”, “Saaransh”,play. A film is an audiovisual medium and the director decides what the audience should see.”

Gadhvi’s most memorable moment on the shoot was when he jumped off the highest freefall point in the world. “It was 125 meters high and I did the jump twice! I however could not watch the cast do the jump. It was too scary.”

Gadhvi, whose directorial debut Tere Liye (2000) and Mere Yaar Ki Shaadi Hai (2002) did not do too well, says he came to action-comedy movie genre “by default. I left home saying I wanted to make films like Amar Akbar Anthony or Dilwale Dulhaniya Le Jayenge. But what Dhoom’s success has done is given me the confidence to try out other genres  maybe a thriller or a horror movie.


was announced today by Michael Lombardo, president, HBO Programming. Iannucci co-wrote and directed the pilot of the series, which he executive produces along with Frank Rich of New York Magazine and Christopher Godsick (“Take the Lead”); Simon Blackwell, who co-wrote the pilot, co-executive produces and Julia Louis-Dreyfus produces. VEEP, which is expected to shoot in Baltimore, will begin production this fall for 2012 debut on HBO.

Set in Washington, D.C., VEEP stars Louis-Dreyfus as former Senator Selina Meyer, who becomes Vice President, only to discover the job is nothing like she expected, but everything she was warned about. Bradshaw plays Sue, Vice President Meyer’s assistant; Chlumsky plays Amy, her chief of staff; Hale plays Gary, her right-hand man; Scott plays Dan, an ambitious director of communications for a senator;race differences in mortality vary by other covariates by testing the interactions of race and other covariates (see [Table 4](#tab4){ref-type="table"}). The results show that no other interactions are significant.

4. Discussion {#sec4}
=============

We examined the role of individual SES and neighborhood SES in explaining race differences in all-cause mortality over time among black and white older adults. We explicitly tested whether race disparities in mortality vary by age and examined the contribution of individual and neighborhood SES to explaining age variations in these race disparities.

One debate in previous studies is whether there are effects of neighborhood SES on mortality for older adults. Some studies found that neighborhood context has no effects on mortality, while other studies showed that there is an association between neighborhood and mortality \[[@B22]\]. We believe that


mortality for older adults. Although only very few studies have implicitly examined this issue, the results have been inconsistent. Some studies showed that individual SES fully mediates the relationship between race and mortality, while other studies found that individual SES helped explain the difference with neighborhood context further explaining the difference. However, none of these prior studies considered or modeled the race crossover effect of mortality between black and white older adults.

In this study, we examined the contribution of individual SES and neighborhood SDI to mortality through two sets of analysis---with and without modeling a racial crossover effect. The analysis without modeling a potential crossover effect showed that individual SES fully mediated the relationship between race and mortality. However, the analysis with the interaction term between age andas efficient catalysts for this transformation. The electron withdrawing ether group activates the aldehyde and therefore facilitates the formation of the key aminal intermediate. The key features of this work are: (i) the reaction is metal-free, (ii) occurs at room temperature and (iii) the aldehyde can be used in catalytic amount. Hence, the tether is both installed and cleaved during the course of the reaction.

![Diamine synthesis *via* retro-Cope elimination.](c6sc04366f-s6){#sch6}

The potential of this approach was further demonstrated with the development of a catalytic enantioselective version ([Scheme 7](#sch7){ref-type="fig"}).^[@cit18c]^ Two readily available chiral aldehydes **22** and **23**, derived from glyceraldehyde and mannose respectively, were found to be efficient both in term of reactivity and enantiocontrol. Furthermore, they allowed the formation of both enantiomers. A limitation of this work was the need


*via* formation of imidazolidines.](c6sc04366f-s12){#sch12}

The oxazolidines could be easily transformed into other useful building blocks ([Scheme 13](#sch13){ref-type="fig"}). Orthogonal deprotection was possible to access either free amine **38** or free alcohol **39**. The hemiaminal tether could be readily removed under acidic conditions to afford amino alcohol **40** in high yield.

![Orthogonal deprotection of oxazolidines.](c6sc04366f-s13){#sch13}

The speculative mechanism of this reaction, based on studies in our group and others,^[@cit24]^ would start with the oxidative addition of an organohalide on a Pd(0) complex **I** to form complex **II** ([Scheme 14](#sch14){ref-type="fig"}). Base mediated ligand exchange on **II** with hemiaminal **41** would generate the Pd([ii]{.smallcaps})-alkoxide **III**. At this point, either the productive key oxypalladation occurs to form intermediate **IV**, or β-hydride elimination is competitive and produces amide **42**.^[@cit25]^ Finally, reductive elimination allows the formation of thetools God has given us to proclaim the gospel today is the medium of film. We live in an age dominated by the media, and since the early days of my ministry, I have seen the way God has used films to reach people for Christ in every kind of culture.

In the pages of this book, Paul Eshleman tells the fascinating story of the film called JESUS, which is a vivid portrayal of the life, death, and resurrection of Jesus using the exact words of the Bible. He recounts the way the film was produced and distributed, in spite of seemingly insurmountable odds. He also tells of lives that have been touched by the Lord through the JESUS film. This story needs to be told, and no one


I Just Saw JESUS and read it with them chapter by chapter—one story after another of the amazing things Jesus Himself does through the JESUS film. All I could think was, "I'd give anything to be a part of this."

Within two years my wife and I uprooted our family of seven from our nice suburban home, resigned all our responsibilities, and headed for Central Asia to plant churches alongside JESUS film teams. There we witnessed the power of God working through the JESUS film firsthand. The region in which we served, Turkic and Persian by heritage, was just emerging from seventy years as part of the Soviet Union. The people were very resistant to Jesus because they understood Him as "the Russian God." However, when they saw Jesuswith the writer of this book when he and his wife, Kathy, were directing a dynamic Campus Crusade for Christ ministry at the University of Wisconsin. Because of his spiritual leadership and developmental skills in management, we asked Paul to coordinate Explo '72, an unprecedented weeklong student training event for eighty thousand. Soon after that I asked him to direct the Campus Ministry of Campus Crusade for Christ.

Paul brought the same godly faith and leadership he exhibited in his other assignments to the JESUS film production and distribution. Both Paul and I are grateful for the vast army of men and women God has raised to show the JESUS film night after night around the world, often at the risk of their lives.

The stories of God's preparation of


pride. In return, God gave me what I longed for: life with a purpose. I was living the greatest adventure I could have imagined.

Suddenly, just ahead of me Steve stopped in his tracks. His body was tense and stiff. I looked up and could not believe my eyes. Wildly painted Maasai warriors had appeared out of nowhere, and before we could move, two dozen fierce-looking natives surrounded us, each gripping a menacing, razor-sharp spear.

"Steve?"

"Stay calm," he said. "Just stay calm."
2

WARRIOR SPEARS

I swallowed hard, wishing my heart would beat quieter, slower, but I could not control the pounding in my chest. I was being sized up, or so I felt as I looked into the eyes of the men surrounding us. They talked among themselves, perhaps discussing what toseveral strands of colorful beads and trinkets and placed them in a tin box. She dipped a soiled piece of rag in the murky wash water beside her and sponged the dust and dirt from her face and arms. Then squatting on the dung floor, she picked up a little stick and scraped the manure and mud from her feet. Jim and I each breathed a silent sigh of relief when she wrapped herself in a coarse, red blanket and settled down on her cowskin to sleep.

For Jim and me, however, sleep was elusive in our cramped quarters. The fire burned lower, but the hut still felt unbearably warm, and next to our bed in a pen made of sticks rested the family's calf, asleep and the picture


to existing anti-Semitism by portraying the Jews as Christ-killers again."

That thought never crossed my mind before. The Jews had not killed Christ; my sin put Him on that Cross. It was true the Jews asked Pilate to crucify Jesus, but a Roman prosecutor sentenced Him, and Roman soldiers nailed Him to the cross. The world crucified the Savior. We decided that to help prevent the Jews from being blamed for Christ's death, we would introduce Pilate with the following words: "He was handed over to Pontius Pilate, the most vicious of all Roman procurators, alone responsible for the crucifixion of thousands." Marc showed his appreciation for our efforts and gave his endorsement to the film.

Archbishop Fulton J. Sheen personally gave us his warm approval.

"You have taken no libertypicture and their part in it. I sensed they felt a deep respect for the message of the film, almost as if called to do a sacred task.

I watched with fascination as each new day of filming unfolded more of the gospel to them. These men were slowly coming to understand who this man, Jesus, really was. It was easy to see the Holy Spirit at work on the set, touching hearts, changing lives.
6

IS JESUS A CHRISTIAN?

Mark stumbled across our company almost four months after we started shooting the film. A college dropout, wandering around Europe hoping to "find himself" somewhere along the way, he came to us looking for a job. We hired him to carry props on our second unit.

The third day on the job, Mark


four years she's been telling me nearly every day that I need to get Jesus into my life." He smiled. He obviously liked his housekeeper. "On the weekends her sister came to relieve her, and she said the same thing. Every morning she'd say a prayer at breakfast . . ." His voice trailed off, and I realized he was choking back tears.

"Two weeks ago my housekeeper died," he said. He looked at me. "Now I don't know where to turn. I think what I need . . . is to get Jesus in my life."

I shared the gospel with him very briefly. He did not need a sermon. He had seen the truth lived before him for years. As we finished talking about the "Four Spiritual Laws,"our prayer efforts. The musical score was completed, recorded, and sounded wonderful. It looked as if things were finally coming together, and with our deadline bearing down on us, it was none too soon—as long as nothing else happened.

* * *

The phone call came early on a Monday morning. A Christian attorney said JESUS was a film of heresy and threatened to obtain an injunction against us. He heard that we filmed the Crucifixion scene without a crown of thorns on Jesus' head, and he accused us of trying to change the Scripture. Luke does not mention the crown of thorns in his account, but the lawyer refused to accept that as reason enough. He would see us in court.

* * *

In September the first completed print of


away in twenty cities!

Not only the evening crowds reached large capacity; the matinees did well also, thanks to the United States Catholic Committee. Anna Greves, an educational consultant from Akron, Ohio, organized a massive effort to bring Catholic school children to special morning and afternoon matinees. An office staff of ten in Akron worked around the clock to get tickets to thousands of schools and to make sure the managers were there to open the theaters for the special morning shows. By the end of the theater run, more than 250,000 Catholic school children had seen JESUS.

In addition, the communications office for the U.S. Catholic Charismatic Renewal shipped tickets to prayer group leaders all over the country. Sister Rosemary in San Bernardino, California, sold more than eight thousandJESUS and that night placed her faith in Christ. She left her old ways and now is involved in a discipling ministry not far from Amsterdam's famous red-light district.

In South Africa the film showed to mixed audiences of blacks and whites, and during its first two months, more than three hundred thousand people saw JESUS.

A theater owner in Zurich, Switzerland, reluctantly agreed to schedule the film. "But only for a few days," he said. "I have to make a profit." Six weeks later nearly forty-eight hundred people had paid to see the film. Another city booked the film for eighteen days; fifty-nine hundred people attended with more than two hundred expressing an interest in becoming believers.

"JESUS Outdraws E.T." the headline read in an English paper. The Classic Cinema


to London (ten of them from India, plus one from Sri Lanka). Completing these translations has added a new significance to my life. Seven months ago, I knew nothing about the film industry; today I feel like a seasoned professional, having accomplished the first major work I was sent to do. God has been good to us, and I feel tremendous satisfaction.

These last two months we worked sometimes day and night until the wee hours of the morning to meet our deadlines. Crises were common. We were trying to turn out one language after another as quickly as we could schedule the voice artist's time. Sometimes we had work in four languages going simultaneously.

The pressure is unending. I go home, but I dream about giving cues and eliminatingroad was slick with mud, and she struggled to keep the little truck out of the drainage ditches on either side.

Gunfire seemed to come from everywhere, and suddenly Diana knew the truck had been hit. The wheel jerked violently in her hands. Over her fear and the crackling sounds of gunfire, she yelled, "Pray!" Suddenly the road made a sharp turn and started down a steep incline.

"Thank You, Jesus! Thank You, Jesus!" Anita cried out over and over. All she could think of was how grateful she felt for each moment they stayed on the road. Life was a gift straight from the hand of God.

Within a few moments they drove out of the range of gunfire, and Diana regained control of the truck. They sped on in


set up bookings for the film JESUS, not to get myself killed.

"I don't know," he answered. It startled me to hear how frightened Adel sounded. He lived here with the fighting and the danger. I assumed you could "get used to it," but something told me now that no one ever did. My heart went out to Adel and his family as I began to realize what they lived with—every day of their lives.

"What're we going to do?" I asked. "Who's fighting whom? Where are they?" Adel Masri was Lebanese; he lived in Beirut. Surely he would have the answers.

"I don't know," he said. "It changes every day. It's probably a new offensive by the Christian Phalangists. They want to get this area back from the Muslims, andthis hotel is owned by Muslims." The firing seemed to increase, and Adel rose up on one elbow to peer out the windows overhead. In a second he dropped back out of sight. "Looks like there's a machine gun nest right outside the window. We'd better just stay low till the firing stops."

"How long?"

"Sometimes only a few hours," he said. "Sometimes . . . much longer."

This was not even my war, yet I might get killed for staying in the wrong hotel. I began developing a plan. Machine gun bullets cannot go through concrete, I reasoned. If we took the mattresses off the beds and barricaded ourselves in the bathroom . . . surely the shells would not be able to go through concrete and a mattress. I


missionaries as a means to exalt the name of Jesus and promote peace and understanding among the peoples of the Middle East.

"Yasser Arafat headquarters the Palestinian Liberation Organization (PLO) in those student apartments over there." He pointed to some buildings near the road. "He lives here, and many of the PLO fighters are students at the University."

"What's all the fighting about?" I asked. "Can anyone really explain it?"

"It isn't easy, but it's a Muslim-Christian thing, Paul. Lebanon has always had both factions, but when the Palestinians were driven out of Israel by the Jews, many of them came here. Arafat formed the PLO in refugee camps to organize the Muslims. A few years ago they came into the city and simply took over the homes of some Christianswould meet me for breakfast at 7:30. I hung up and began thinking about a shower when Adel called. The windows were shot out in his apartment, they had no electricity, and he was moving his family and food to another location—but everyone was all right.

10:00 a.m.

Contracts were signed, and the opening dates set for three theaters in Lebanon at Christmastime—providing the theaters still stood by that time. I offered the cab driver a little extra money to take me to the airport. Although reluctant, he said he would try.

As Beirut rolled past my taxi window, my heart felt heavy. So many buildings lay in rubble along the street; seventy-five cars had been blown up during the night; thirty-four people had been injured; twelve had died.

For some reason,


of one small oversight. In cursing believers, he had brought the curse against himself and others who had not believed. He had not known how well God protects His own.

To those of us "older," more westernized believers, voodoo and demons, healings and angels are somewhat "out of the ordinary" and a little hard to believe. Certainly we acknowledge that God still works miracles—after all, He is the same yesterday, today, and forever. Yet it remains a bit baffling to some of us "conservative" folks to hear what happens in other parts of the world.

Not so among the new believers. To those who know nothing more of Jesus than what they see in the film, it seems perfectly logical that the miracles they witness in JESUS might have occurredbeginning of the pictures, he looked carefully at each face. Some were beautiful, some grotesque, but finally he looked again into the eyes of the man Jesus. They could not all be the same, he reasoned. There had to be one God more powerful than all the rest, the one true God. Yet how could he know which one? A test. That was the answer; a test that only the most powerful God of all would be able to pass.

The searching bhagat laid a tiny ball of dried cow dung, a common fuel burned in India, directly in front of each picture. He believed only the one true God had power enough to ignite the ball of fuel that sat before His picture. He placed the last of


it out and stepped back to wait.

Almost immediately the bit of fuel in front of the picture of Jesus burst into flame and burned until gone. It was the only one and enough to convince him that Jesus was the one true God he longed to know. Without a second thought he rid his home of the false gods he had worshipped, and now he spends much of his time sharing with the other bhagats of his city how he is so sure Jesus is the one true God.
12

BUT DO THEY LAST?

The village of Pamongan sits in the heart of the oldest Islam settlement in all of Indonesia. The first fiery Muslim missionaries swept across this part of central Java nearly six hundred years ago, choosing Demak, aOne radical Hindu group entered a home where several Christians had gathered, beat them severely, and told them they could no longer meet to worship Christ. In spite of it all, God is in control.

"One day I heard about the JESUS film and the training in evangelism that Campus Crusade provides. I remember praying earnestly one night that somehow God would let us use this film; I asked Him for ten showings in our area. The very next day God sent Charlie Abro from India Campus Crusade to my house. He explained that he was training film team workers to go into North India, and he wondered if I would like to use them for the next forty days."

He laughed out loud, remembering the excitement of God's answer


in the mountains and nestled beneath lush, tropical vegetation, is nearly inaccessible, and it seemed the only possible way to get the equipment in was by helicopter. Since our teams run on tight budgets, especially in the jungle, a helicopter shuttle was eliminated as a possibility because of the expense. Sadly, the team sent word back to the village that they could not come because of transportation limitations.

The next day, as one young team member stood under a tree finishing his morning coffee, something appeared that he never expected to see. There in the clearing before him stood two gigantic elephants and a smiling messenger. "The elephants have come to take you over the mountain," the little man said. The team member set his coffee down and wentJESUS because it was the first time they heard how to know God. That is what they wanted: to know God.

One young couple I spoke with invited me into their home. Their painfully crude shack made it easy to see they did not have much. When I asked them what they liked most about Jesus, the man said, "He cares about poor people like us." Softly his wife added, "I knew He was poor like we are because He never carried a suitcase."

Another couple smiled and said, "We have been so worried because we owe others a great deal of money. But when we saw the picture, we learned that Jesus said that if He took care of the birds and flowers of the field, He would also


Neil Bailey Swimming - a family run learn to swim school with extensive
experience

Operating in the High Wycombe, Beaconsfield and Marlow areas.
Led by Neil Bailey a fully qualified Amateur Swimming Association teacher, he
has over 16 years club experience, teaching both children and adults. He runs
programmes within swimming clubs, schools and sports societies, and has mentored
many swimming teachers and coaches. He believes there is an acute shortage of
quality teaching in this area and working with his own team he is able to
deliver a high quality teaching experience.

An expert, safe and progressive environment that achieves results

All of our teachers are Amateur Swimming Associated qualified to Levelís 1
and 2 with an up to date enhanced CRB disclosure. We offer small classes of
between six to eight children per teacher and use swimming assistants      def box_size(corners):
            size = 1
            for idim in range(self.dim):
                size *= corners[idim + self.dim] - corners[idim] + 1
            return size

        self._offsets = {}
        num_comp = self._handle.attrs["num_components"]
        level = 0
        while True:
            lname = "level_%i" %


    if not (len(chunks) == len(chunks[0].objs) == 1):
                raise RuntimeError

            grid = chunks[0].objs[0]

            for ftype, fname in fields:
                rv[ftype, fname] = self._read_particles(grid, fname)

            return rv

        rv = {f: np.array([]) for f in fields}
        for chunk in chunks:
           the stellar exposures for each night were averaged in order to define a single aperture to use for the spectral extraction. This included a subtraction of the residual background level between orders. The aperture was used to extract 1-dimensional spectra from the stellar, comparison and flat-field exposures. A mean, normalized 1-dimensional flat was divided into the extracted spectra to obtain the most consistent flat-fielded spectra possible. The wavelength calibration was done with Thorium-Argon arcs. Heliocentric and differential radial velocity corrections were applied. In 2001 Th-Ar arcs were taken with every target while in the 2002 observing runs, each stellar exposure was bracketed with an arc. This allowed differential radial velocities ($\Delta$$RV$) to be measured to better than 20 m/s. Detailed discussion on the $RV$ can be found in


is closer to 9 days and the Ca II emission is significantly enhanced in HD 179949 relative to the other stars.

If the star is indeed tidally synchonized with the planet, as is believed to be the case for $\tau$ Boo, then the modulation in the emission observed with the 3.093-day period may be tracking a persistent stellar surface feature. However, tidal synchronization of HD 179949 is not a favoured scenario for two reasons. Firstly, the tidal synchonization timescale for the system $\approx$ 700 Gyr using a $M_{p}$sin$i = 0.84 M_{J}$. (See Equation 1 of Drake et al. 1998). Even if $i = 21^{\circ}$, as would be the case for $v$ = 17.5 km s$^{-1}$ and $M_{p} = 2.34 M_{J}$, then the sychronization timescale is still very long at 79 Gyr. Secondly, ROSATone observing season from the ground. Space based observations will not only increase the phase coverage, but will also allow observations of other activity diagnostics such as transition region and coronal lines in the UV and FUV. Such mapping of planet-induced activity at varying stellar atmospheric depths will allow characterization and quantification of the physical interaction between the magnetically heated layers of the star and the planet’s magnetosphere.

Research funding from the Canadian Natural Sciences and Engineering Research Council (G.A.H.W. & E.S.) and the National Research Council of Canada (D.A.B.) is gratefully acknowledged. We are also indebted to the CFHT staff for their care in setting up the CAFE fiber feed and the Gecko spectrograph.

Baliunas S.L. et al., 1995, , 438, 269.

Butler, P., Marcy G., Williams, E., Hauser, H.,


to stay in your day job, or quit that day job and move into an alternative career.

Keeping Your Day Job

Well, what’s the worst case for staying at your day job? Let’s look at this like this:

Is it soul sucking? Is it hacking away at your HP one by one? Do you find yourself constantly hitting the liquor store every weekend to restock your supply of “elixirs?”

If this is the case, how long can you keep this up?

Are you just doing it for the money? And I know, money seems great, right? It’s a lot of motivation for most people, but sometimes a well-paid job just leads to an increased cost of living due to all the creature comforts you get used to.

THIS is what makes golden handcuffs soto gas densities of 10$^2$ to 10$^{8.5}$ cm$^{-3}$, with electron temperatures $\sim$ 12,000 K – 150,000 K. A large range of distances from the central source implies significant line width variation among the coronal lines. We identify several line ratios which could be used to measure relative abundances, and we use these to show that the coronal line gas is likely to be dust free.
author:
- 'Jason W. Ferguson, Kirk T. Korista, Gary J. Ferland'
title: |
    Physical Conditions of the Coronal\
    Line Region in Seyfert Galaxies
---

ø[ø]{}

Introduction
============

Given their high ionization potentials ($\chi$ $>$ 100 eV) the presence of highly ionized optical forbidden lines, such as \[\] $\lambda$6087, \[\] $\lambda$6375, \[\] $\lambda$7892, and \[\] $\lambda$5303, in the spectra of Seyfert galaxies points to very energetic processes at


density clouds ionized by a continuum similar to a typical Seyfert galaxy with $L_{ion} = 10^{43.5}$. The shape of the ionizing continuum was chosen to be a combination of a UV-bump of the form $f_{\nu} \propto \nu^{-0.3} exp(-h\nu /kT_{cut})$ and an X-ray power law of the form $f_{\nu} \propto \nu^{-1.0}$ spanning 13.6 eV to 100 keV. The UV-bump cutoff temperature, $T_{cut}$, was chosen such that the UV-bump peaked (in $\nu F _{\nu}$) at 48 eV. The UV and X-ray components were combined with a typical Seyfert UV to X-ray spectral slope, $\alpha_{ox} = -1.2$.

[Cloudy]{} now considers the ionization balance of the first thirty elements; we assume solar abundances from Grevesse & Anders (1989) and Grevesse & Noels (1993).

H :1.00E+00 He:1.00E-01 Li:2.04E-09 Be:2.63E-11 B :7.59E-10 C :3.55E-04 N :9.33E-05 O :7.41E-04 Fand IR continuum optical depths are small, in comparison to the resonance lines which are readily destroyed by grains. We include dust of the type found in the Orion nebula (Baldwin et al. 1991) in grid calculations at radii consistent with the sublimation temperatures of the silicate and graphite grains discussed by Laor & Draine (1993) and Netzer & Laor (1993). In particular, inside the graphite grain boundary the gas had solar abundances and no grains were present. The Orion type graphite grains were turned on at a radius of $10^{16.9}$ cm (where T$_{dust}$(graphite) $\approx$ 1750 K) and the carbon abundance was set to the value given below. The Orion type silicate grains were turned on at a radius of $10^{17.6}$ cm (where T$_{dust}$(silicate) $\approx$ 1400 K), and the gas abundances of the


strengths. For example, the most recently computed collision strengths of \[\] and \[\] have differed by factors of 3 – 10 (Mohan, Hibbert, & Kingston 1994; Pelan & Berrington 1995; Dufton & Kingston 1991; Storey, Mason, & Saraph 1996). No collision strengths which include resonances have been calculated for \[\], and those which do for \[\] (Keenan & Norrington 1987) may be in doubt. Preliminary analysis (see also column 7 of Table 1) indicates that if the most recent collision strengths for \[\] and \[\] are correct (Pelan & Berrington; Storey et al.), then the iron abundance would have to be arbitrarily depleted relative to the other elements (e.g., Mg, Si, Ca) by more than a factor of $\sim 10$ compared to solar, which does not make sense. The alternativebefore arriving at the ion detector, enabling mass resolution based on time-of-flight. In a typical TOF-MS, ions travel along a drift direction through one or more gas-filled ion guides, and one or more beam-limiting apertures operating in a collision-free environment, and into the pulsed ion accelerator. In an orthogonal acceleration TOF-MS (oaTOF-MS), the ion accelerator receives the ions along the drift direction and injects the ions along an acceleration direction orthogonal to the drift direction. The flight tube may include one or more ion mirrors (or “reflectrons”) that increase the length of the ion flight path and provide certain advantages.
In TOF-MS, chemical composition is determined by accurately measuring the masses of individual ions drawn from the sample. The critical mass measurement stage is realized by measuring the time


elapsed as ions travel from an ion accelerator through a known path length. Ions end their flight on a fast ion detector at which a single ion is transformed into a nanosecond-scale electronic signal, which is digitized with a high speed data acquisition system. The inherent simplicity and speed of this process translates into multiple analytical advantages for the end user. Because TOF-MS is able to gather a complete mass spectrum for each firing of the ion accelerator, it is particularly well-suited for tandem mass spectrometry (MS/MS) in which the fragmentation spectrum associated with a particular parent ion mass is measured.
Orthogonal-acceleration TOF-MS instruments have a primary ion beam that travels at low energy (10-50 eV) in a direction known as the drift direction, and an ion accelerator thatwith traits. Second, gene modules significantly associated with traits are selected. Then, the prior knowledge guided eQTL mapping method is performed on selected gene modules. In the second step, weighted correlation network analysis (WGCNA) is used for finding clusters (modules) of highly correlated genes \[[@CR14]\]. Gene modules significantly associated with traits are selected.

For multiple correlated genes in selected gene modules, we used the multiple-response linear regression model LassoM \[[@CR15]\] for eQTL mapping. Throughout this article, we use the letter "M" following the original model to represent multi-response model.

Consider *K* genes *Y*= \[ *Y* ~1~,...,*Y* ~*S*~\]^*T*^∈*R* ^*S*×*K*^ for *S* samples, a linear regression model for the functional mapping from *M* SNPs to *K* gene is given as $$\documentclass[12pt]{minimal}


               \usepackage{amssymb}
                \usepackage{amsbsy}
                \usepackage{mathrsfs}
                \usepackage{upgreek}
                \setlength{\oddsidemargin}{-69pt}
                \begin{document}$\|\beta _{j}\|_{2}^{2}$\end{document}$. The objective function becomes: $$\documentclass[12pt]{minimal}
                \usepackage{amsmath}
         K}\right)}\frac{1}{2N}\sum\limits_{i=1}^{N}\|y_{i}-\beta_{0}-x_{i}\beta\|_{F}^{2}\\ &\quad+ \lambda \sum\limits_{j=1}^{m}p_{j}\left[(1-\alpha)\|\beta_{j}\|_{2}^{2}+\alpha\|\beta_{j}\|_{1}\right] \end{aligned}  $$ \end{document}$$

From this model, we can derive three models: LassoM, multi-response ridge (RidgeM) and multi-response elastic net(elasticM), and they differ in elastic-net penalty *α*: Lasso (*α*=1), ridge (*α*=0) and elastic net (*α*=0.5). They can be combined with prior knowledge *p* ~*j*~ to generate their prior knowledge on multi-response models: LassoMP, RidgeMP and elasticMP.

Results {#Sec3}
=======

Simulation study {#Sec4}
----------------

We performed the simulation study to compare LassoM and LassoMP with two other multi-task Lasso methods GFLasso \[[@CR6]\] and FMPR \[[@CR7]\]. GFLasso and FMPR are implemented in the R package FMPR. To demonstrate the effect of using prior knowledge, we also compared LassoM and LassoMP with RidgeM, RidgeMP, elasticM, and elasticMP. They are implemented in the R package glmnet \[[@CR16]\]. In RidgeMP, LassoMP and elasticMP, the penalty


is negatively associated with IF2. Since IF2 and IF3 represent high infection severity, the Darkmagenta and Blue modules correspond to PC3 and PC4, and it indicates that they capture minor factors for infection. Four gene modules are positively associated with SEV, LSE and IC, but only the Darkgreen is negatively associated with LSE.

### Prior knowledge guided eQTL mapping {#Sec17}

We identified eQTLs in two gene modules, Saddlebrown and Darkgreen, using LassoM. Saddlowbrown is negatively associated with IF2 and Darkgreen with LSE. eQTL mapping is performed on Darkgrey, Saddlowbrown, Darkgreen and Yellow using LassoM and LassoMP. Subsequently, we compared LassoM and LassoMP on four gene modules: Darkgrey, Saddlebrown, Darkgreen, and Yellow using 5-fold cross validation (Fig. [3](#Fig3){ref-type="fig"}). Prior knowledge for each gene module using LassoMP is selected from candidate markersgenes, which is applicable to a wide range of species. Knowledge driven methods, such as Lirnet, are heavily dependent on rich biological knowledge in model organisms. In our method, modules are generated in WGCNA using hierarchical clustering, which is an unsupervised method. Also, QTL and eQTL mapping are performed purely on genotypic, transcript profiling and phenotypic data. Any biological knowledge of these genetic markers and genes are not used in the mapping process. A few studies used biological knowledge in eQTL mapping \[[@CR5], [@CR8], [@CR9]\]. Their methods are applicable for resource rich organisms such as yeast, human, mouse and Arabidopsis. For other species, gene functional annotations are very limited.

In our method, selection of candidate genes takes evidence in trait-gene associations and gene-SNP associations. For example, some gene expression


gene co-expression network analysis

We would like to thank Dan Tulpan for providing the locations of barley genes.

Funding {#d30e4317}
=======

This work was supported by National Research Council Canada and Canadian Wheat Alliance.

Availability of data and materials {#d30e4322}
==================================

The source code and data used in the simulation study and case studies are available from <https://github.com/redsofa/LassoMP>.

Authors' contributions {#d30e4332}
======================

YW conceived the idea and performed the data analysis. RR collected the data and performed part of data analysis. YW and YP wrote the paper. All authors read and approved the final manuscript.

Competing interests {#d30e4337}
===================

The authors declare that they have no competing interests.

Consent for publication {#d30e4342}
=======================

Not applicable.

Ethics approval and consent to participate {#d30e4347}
==========================================

Not applicable.
Q:

Extrapolation Handler and NIntegrate: Bug?

I have an list of data which I interpolate such that it returns the value 0 in case I give it values outside of its domain:
g = Interpolation[Transpose[{{1, 2, 3, 4, 5}, {1, 2, 4, 1, 4}}],
  "ExtrapolationHandler" -> {0 &, "WarningMessage" -> False}]

Which works fine:
g[0] and g[100] both return 0
However, if I want to integrate this function, I get an error message:
NIntegrate[g[x], {x, 0, 100}]

InterpolatingFunction::dmvali: The integration endpoint 0 in dimension
  1 lies outside the range of data in the interpolating function.
  Extrapolation will be used. InterpolatingFunction::dmvali: The
  integration endpoint 100 in dimension 1 lies outside the range of data
  in the interpolating function. Extrapolation will be used.

and the output is some large (incorrect) number.
Is this a


and in whom the method was used; and 4) whether there were withdrawals or dropouts.

Statistical analysis {#S0002-S2005}
--------------------

RevMan 5.3 software (Cochrane Collaboration, London, UK) was used to conduct all statistical analyses. The incidence of etomidate-induced myoclonus and its degrees were reported by risk ratio (RR) and 95% CIs. Heterogeneity of the included studies was assessed with the *I*^2^ statistic, and *I*^2^\>50% was regarded as significant.[@CIT0011] Considering the heterogeneity between trials with respect to different doses of butorphanol administered to prevent etomidate-induced myoclonus, we used the random-effects model to calculate pooled effects.

To test the robustness of the pooled results, sensitivity analysis was performed by using both the random-effects and fixed-effects analysis models.

Results {#S0003}
=======

Characteristics of the included studies {#S0003-S2001}
---------------------------------------

We identified 65 potentially relevant studies in the initial search, and 6 ofremember students in my program complaining that the MLS coursework wasn’t “academic” enough, but I think it’s important to remember that you are in a professional program. You are training for a career, not writing a dissertation. It’s up to you to turn the coursework into something worthwhile. Work as a paraprofessional or library assistant during library school. Do an internship, practicum, or volunteer. These experiences will help you land a job better than any course you take.

I’ve never looked at anyone’s résumé and thought, “Wow, they graduated from a top ranked library school! Let’s hire him/her.” So ignore the rankings. Focus on gaining some relevant experience instead.


coyz, 31 Mar 2017There is not significant change to spend $800 or more for s8 from s7 edge. For me s7 edge stil... moreyou're right it is a smaller battery but isn't the processor supposed to make the battery last longer?

Troll.Spotted, 03 Apr 2017WOW... You can buy S8+ but you can't buy usb type c adapter... :)
Good luck,,,Wow you can use USB type C adapter with the VR headset, just try with this humongous phone if it will fit in the VR headset with the USB type C adapter and let us know.

Hephaestus8, 03 Apr 2017It actually come with the new gear vr if you even pre ordered it already. I assumed you havent. No it doesn't come with free VR headset. The only freebies are wireless chargerplummeted. Fast forward to 2013 and the technology began catching up to the vision for the movie. Still, when Ben and his team decamped to the South West coast of Africa for a gruelling six-month desert shoot, there were just as many unknowns as there were knowns.

SCRATCHING PLAN A

Plan A was for Ben to be sitting in the sanitised comfort of an OB-style truck, making tweaks to finely tuned levels coming from DPA lavs on Lectrosonics packs, RF’ed back to base as the production would roll back and forth past him in the desert.

Ben Osmo: “In the original brief the vehicles might drive 500 metres to a kilometre away from us. In other words they might travel 1, 2, 3km-max, then stop. We did the first test and