it. Here's a sketch:
Define an operator on your Hilbert space $ H $ as $ T(v) = \int_{G} \pi(g)(u) \langle v, \pi(g)u \rangle dg $ where $ u \in H $ is an arbitrary unit vector. We claim now, that $ T $ is a compact, positive, non-zero operator and also an intertwiner, i.e. $ T \circ \pi(g) = \pi(g) \circ T $. Positivity, non-zero and intertwiner are quite straightforward. To show compactness of $ T $, you approximate $ T $ (in norm) by compact operators. (This happens analogue to the approximation of Riemann integrals by Riemann sums; this is one way to define vector valued integrals as used in the defintion of $ T $.)
Since $ T $ is compact and positive, it has an eigenvalueterminus with \[γ-^32^P\] ATP using T4 polynucleotide kinase. The mobility shifts were conducted according to previously reported protocols ([@gkt479-B27],[@gkt479-B36]). Briefly, 100 fmol of the DNA substrates were incubated in the presence of binding buffer \[25 mM HEPES (pH 7.8), 5 mM MgCl~2~, 80 mM KCl, 1 mM EDTA, 1 mM DTT, 10% glycerol, 1 mg/ml bovine serum albumin (BSA)\] with 100 nM purified MSH2-MSH6 complex at room temperature for 30 min along with poly dI-dC competitor DNA (20-fold excess). The detailed protocol for the purification of the complex is described ([@gkt479-B36]). Reactions were resolved on a 4% polyacrylamide gel at 4°C, dried and exposed with X-ray film for autoradiography.

Statistical analysis
--------------------

Statistical analysis was performed by student's *t*-test using R.2.7.0 software.

RESULTS
=======

Cisplatin resistance following BER and MMR downregulation
---------------------------------------------------------

To address the effect


of BER and MMR downregulation on cell viability in response to cisplatin treatment, clonogenic assays were performed in proficient and deficient cells ([Figure 1](#gkt479-F1){ref-type="fig"}). Wild-type and Polβ null/deficient MEFs ([Figure 1](#gkt479-F1){ref-type="fig"}A) and MDA-MB-231 cells ([Figure 1](#gkt479-F1){ref-type="fig"}B) were transfected with siRNA directed against MSH2 to examine cisplatin sensitivity. Both Polβ null and Polβ deficient cells displayed cisplatin resistance compared with wild-type cells, consistent with our previous report ([@gkt479-B30]). Knockdown of MSH2 in wild-type cells enhanced cisplatin resistance by ∼2-fold, which is consistent with the literature ([@gkt479-B14; @gkt479-B15; @gkt479-B16; @gkt479-B17],[@gkt479-B37]). However, knockdown of MSH2 in Polβ null/deficient cells did not give rise to any additional resistance to cisplatin ([Figure 1](#gkt479-F1){ref-type="fig"}A and B). To confirm these results, we used MX to inhibit BER in MSH2-proficient and -deficient cells ([Figure 1](#gkt479-F1){ref-type="fig"}C). MXkDa dRP lyase domain and a 31 kDa polymerase domain ([@gkt479-B46],[@gkt479-B47]). Asp256 is one of the three active site aspartates in the polymerase domain, which is critical for the nucleotidyltransferase mechanism. Menge *et al.* ([@gkt479-B48]) showed that mutation of Asp256 to alanine (D256A) completely abolished the polymerase activity of Polβ. Although the D256A Polβ mutant completely lacks the gap-filling DNA synthesis, it retains the dRP lyase activity ([@gkt479-B49]). Several mutations in polymerase or the lyase domain of Polβ showed the importance of these domains in the cytotoxicity of certain DNA-damaging agents ([@gkt479-B49; @gkt479-B50; @gkt479-B51; @gkt479-B52; @gkt479-B53; @gkt479-B54; @gkt479-B55]). Therefore, we re-expressed wild-type Polβ and a variant deficient in polymerase activity (D256A) in Polβ knockdown cells to determine the importance of the polymerase domain/activity in mediating cisplatin sensitivity. Consistent


with a previous report, Polβ KD cells displayed cisplatin resistance ([@gkt479-B30]). Re-expressing wild-type Polβ in the KD cells restored cisplatin sensitivity in both MTS ([Figure 3](#gkt479-F3){ref-type="fig"}A) and colony survival assays ([Figure 3](#gkt479-F3){ref-type="fig"}B). Interestingly, expression of the D256A Polβ mutant in the KD cells resulted in sensitivity to cisplatin as well. These data indicate that loss of Polβ protein can drive cisplatin resistance, but re-expression of wildtype or the presence of a polymerase dead mutant can mediate cisplatin sensitivity. Figure 3.Cisplatin cytotoxicity. (**A**) Polβ KD, KD/wt Polβ and KD/D256A cells were treated with cisplatin for 2 h, and then cell sensitivity was determined by MTS assay. (**B**) Cells were treated with cisplatin and MX+cisplatin, and clonogenic assays were performed as described. (**C**) Cells were transfected with control or MSH2MMR resulted in cisplatin resistance as expected. Interestingly, when both BER and MMR pathways are targeted, there was no additional resistance to cisplatin. Liu *et al.* ([@gkt479-B58]) showed that disrupting BER by MX treatment enhanced sensitivity to methylating and DNA cross-linking agents in MMR-proficient as well as MMR-deficient cells ([@gkt479-B59]). Recent synthetic lethality studies show that disrupting BER by downregulation of DNA polymerases can be a potential target in MMR-deficient cancers ([@gkt479-B60]). In the current study, MX treatment as well as Polβ deficiency displayed neither hypersensitivity nor enhanced resistance to cisplatin treatment in MSH2-deficient cells. The ∼2-fold cisplatin resistance observed following BER or MMR downregulation remained the same following downregulation of both DNA repair pathways. Therefore, we hypothesize that BER and MMR pathways function together in the same


In support of this, BER processing upstream of Polβ is intact in the D256A mutant cells, and if this processing is blocked by MX, cisplatin resistance is still observed.

Our previous results demonstrated that Polβ is mutagenic at sites flanking a cisplatin ICL; thus, we assessed the requirement of Polβ polymerase activity in MMR activation in response to cisplatin ([@gkt479-B30]). We downregulated MSH2 in Polβ KD, KD/wt Polβ and KD/D256A cells. As expected, wild-type cells displayed cisplatin sensitivity, and Polβ KD cells as well as MSH2 knockdown resulted in cisplatin resistance. However, knockdown of MSH2 in the Polβ D256A mutant cells showed no additional effect on cell sensitivity or cisplatin DNA repair. This is an important observation, as these data provide compelling evidence for a direct role of Polβ     assertThat(terms.get(2).bytes(), equalTo(termQuery3.getTerm().bytes()));
        assertThat(terms.get(3).field(), equalTo(termQuery4.getTerm().field()));
        assertThat(terms.get(3).bytes(), equalTo(termQuery4.getTerm().bytes()));
    }

    public void testExtractQueryMetadata_booleanQueryWithMustNot() {
        BooleanQuery.Builder builder = new BooleanQuery.Builder();
        TermQuery termQuery1 = new TermQuery(new Term("_field", "_term"));
        builder.add(termQuery1, BooleanClause.Occur.MUST_NOT);
        PhraseQuery phraseQuery = new PhraseQuery("_field", "_term1", "term2");
        builder.add(phraseQuery, BooleanClause.Occur.SHOULD);
        BooleanQuery booleanQuery = builder.build();

        Result result = analyze(booleanQuery, Version.CURRENT);
        assertThat(result.verified, is(false));


 TermQuery termQuery1 = new TermQuery(new Term("_field", "_term"));
        ConstantScoreQuery constantScoreQuery = new ConstantScoreQuery(termQuery1);
        Result result = analyze(constantScoreQuery, Version.CURRENT);
        assertThat(result.verified, is(true));
        assertThat(result.minimumShouldMatch, equalTo(1));
        List<QueryExtraction> terms = new ArrayList<>(result.extractions);
        assertThat(terms.size(), equalTo(1));
        assertThat(terms.get(0).field(), equalTo(termQuery1.getTerm().field()));
        assertThat(terms.get(0).bytes(), equalTo(termQuery1.getTerm().bytes()));
    }

    public void testExtractQueryMetadata_boostQuery() {
        TermQuery termQuery1 = new TermQuery(new Term("_field", "_term"));
        BoostQuery constantScoreQuery = new BoostQuery(termQuery1, 1f);
       Result result = analyze(constantScoreQuery, Version.CURRENT);
        assertThat(result.verified, is(true));
        assertThat(result.minimumShouldMatch, equalTo(1));
        List<QueryExtraction> terms = new ArrayList<>(result.extractions);
        assertThat(terms.size(), equalTo(1));
        assertThat(terms.get(0).field(), equalTo(termQuery1.getTerm().field()));
        assertThat(terms.get(0).bytes(), equalTo(termQuery1.getTerm().bytes()));
    }

    public void testExtractQueryMetadata_commonTermsQuery() {
        CommonTermsQuery commonTermsQuery = new CommonTermsQuery(BooleanClause.Occur.SHOULD, BooleanClause.Occur.SHOULD, 100);
        commonTermsQuery.add(new Term("_field", "_term1"));
        commonTermsQuery.add(new Term("_field", "_term2"));
        Result result = analyze(commonTermsQuery, Version.CURRENT);


dsl and are therefor not supported:
        // 1) SpanPositionRangeQuery
        // 2) PayloadScoreQuery
        // 3) SpanBoostQuery

        // The following span queries can't be supported because of how these queries work:
        // 1) SpanMultiTermQueryWrapper, not supported, because there is no support for MTQ typed queries yet.
        // 2) SpanContainingQuery, is kind of range of spans and we don't know what is between the little and big terms
        // 3) SpanWithinQuery, same reason as SpanContainingQuery
       BooleanClause.Occur.MUST);
        BooleanQuery bq1 = builder.build();
        result = analyze(bq1, Version.CURRENT);
        assertThat(result.verified, is(true));
        assertThat(result.matchAllDocs, is(true));
        assertThat(result.minimumShouldMatch, equalTo(0));
        assertThat(result.extractions.size(), equalTo(0));

        builder = new BooleanQuery.Builder();
        builder.add(new MatchAllDocsQuery(), BooleanClause.Occur.MUST_NOT);
        builder.add(new MatchAllDocsQuery(), BooleanClause.Occur.MUST);
        builder.add(new MatchAllDocsQuery(), BooleanClause.Occur.MUST);
        BooleanQuery bq2 = builder.build();
        result = analyze(bq2, Version.CURRENT);


     assertThat(result.verified, is(true));
        assertThat(result.matchAllDocs, is(false));
        assertThat(result.minimumShouldMatch, equalTo(1));
        assertThat(result.extractions.size(), equalTo(1));
        assertTermsEqual(result.extractions, new Term("field", "value"));

        builder = new BooleanQuery.Builder();
        builder.add(new MatchAllDocsQuery(), BooleanClause.Occur.SHOULD);
        builder.add(new MatchAllDocsQuery(), BooleanClause.Occur.SHOULD);
        builder.add(new TermQuery(new Term("field", "value")), BooleanClause.Occur.SHOULD);
        builder.setMinimumNumberShouldMatch(2);
        BooleanQuery bq7 = builder.build();
        result = analyze(bq7, Version.CURRENT);
        assertThat(result.verified, is(true));
   assertThat(result.verified, is(true));
        assertThat(result.minimumShouldMatch, equalTo(0));
        assertThat(result.extractions.isEmpty(), is(true));

        query = new SynonymQuery(new Term("_field", "_value1"), new Term("_field", "_value2"));
        result = analyze(query, Version.CURRENT);
        assertThat(result.verified, is(true));
        assertThat(result.minimumShouldMatch, equalTo(1));
        assertTermsEqual(result.extractions, new Term("_field", "_value1"), new Term("_field", "_value2"));
    }

    public void testFunctionScoreQuery() {
        TermQuery termQuery = new TermQuery(new Term("_field", "_value"));
        FunctionScoreQuery functionScoreQuery = new FunctionScoreQuery(termQuery, new RandomScoreFunction(0, 0, null));


 queryTerms2 = terms(new int[]{1});
        result2 = new Result(true, queryTerms2, 1);
        result = selectBestResult(result1, result2);
        assertSame(queryTerms2, result.extractions);

        queryTerms1 = terms(new int[]{10}, "123");
        result1 = new Result(true, queryTerms1, 1);
        queryTerms2 = terms(new int[]{1});
        result2 = new Result(true, queryTerms2, 1);
        result = selectBestResult(result1, result2);
        assertSame(queryTerms1, result.extractions);
        assertFalse(result.verified);

        queryTerms1 = terms(new int[]{10}, "1", "123");
      Query query = IntPoint.newRangeQuery("_field", 10, 20);
        Result result = analyze(query, Version.CURRENT);
        assertFalse(result.verified);
        assertThat(result.minimumShouldMatch, equalTo(1));
        List<QueryAnalyzer.QueryExtraction> ranges = new ArrayList<>(result.extractions);
        assertThat(ranges.size(), equalTo(1));
        assertNull(ranges.get(0).term);
        assertEquals("_field", ranges.get(0).range.fieldName);
        assertDimension(ranges.get(0).range.lowerPoint, bytes -> IntPoint.encodeDimension(10, bytes, 0));
        assertDimension(ranges.get(0).range.upperPoint, bytes -> IntPoint.encodeDimension(20, bytes, 0));

        query = LongPoint.newRangeQuery("_field", 10L, 21L);
        result = analyze(query, Version.CURRENT);


    .build(),
                BooleanClause.Occur.MUST
        );
        Result result = analyze(builder.build(), Version.CURRENT);
        assertThat(result.verified, is(false));
        assertThat(result.matchAllDocs, is(false));
        assertThat(result.minimumShouldMatch, equalTo(2));
        assertTermsEqual(result.extractions, new Term("field", "value1"), new Term("field", "value2"),
                new Term("field", "value3"), new Term("field", "value4"));

        builder = new BooleanQuery.Builder().setMinimumNumberShouldMatch(2);
        builder.add(
      a society in which some are racists who act cruelly toward the black man, and others, even strangers, go out of their way to help him.

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Otomo, we learn, came from Liberia by way of the Cameroons, where his father fought for the Germans in World War I and was endangered as a German sympathizer. Technically, as one of the police officers observes, he may have had the right to German citizenship. But his only official papers are a temporary passport, not good enough to qualify him for a minimum-wage job he's turned away from at dawn. Before he's turned down, men make fun of his shoes--slippers they call "jungle creepers." Why is it assumed that the poor want to dress the way they must? There is a moment


  var categoryTask = _categoryRepository.Categories
                .FirstOrDefaultAsync(x => viewModel.Category.CategoryId == x.CategoryId);

            Task.WhenAll(advertisersTask, categoryTask);

            var advertisers = advertisersTask.Result;
            var category = categoryTask.Result;

            if (!advertisers.Any())
            {
                ModelState.TryAddModelError("Advertisers", "Нет ни одного рекла");
            }

  Laravel (это php-фреймворк, если меня читают матерые дотнетчики и такие господа просто не знают про существование какого-то Laravel). Итак:
$funnel = Funnel::where('id', '=', $funnelId); // $funnelId, допустим, я получил из реквеста и это int

$funnel->isActive = true;
$funnel->save();

Все. Это первый случай. И все работает! Теперь многие-ко-многим:
$funnel = Funnel::where('id', '=', $funnelId);
$funnel->advertisers()->sync($arrayWithAdvertisersIds);

, где advertisers() - это метод, устанавливаемый в модели Funnel чтоб показать ОРМ, что это отношение многие-ко-многим. А $arrayWithAdvertisersIds это массив int идентификаторов сущности Advertiser, допустим, полученных из реквеста. Ну разве не более френдли? Кто что думает? Прошу покритиковать мой код и буду благодарен за дельные замечания, которые смогли бы упростить жизнь читающим. Спасибо за внимание!

A:

Entity Framework реализует паттерн Единица работы (Unit of Work, UoW). Его назначение — представлять бизнес-транзакции на уровне предметной области (не на уровне доступа к данным).
Единица работы


response_data[11..-1] # cut out acpi data
    if sq_bit.eql?(0b10000000)
      ioa = response_data[0..3]
      response_data = response_data[3..-1]
      i = 0
      while response_data.length >= 2
        print_good("    IOA: " + String((ioa[2].unpack('H*').first + ioa[1].unpack('H*').first + ioa[0].unpack('H*').first).to_i(16) + i) + \
                   " VTI: 0x" + response_data[0].unpack('H*').first + " QDS: 0x" + response_data[1].unpack('H*').first)
        response_data = response_data[2..-1]
        i += 1
      end
    else
     while response_data.length >= 5
        ioa = response_data[0..4]
        print_good("    IOA: " + String((ioa[2].unpack('H*').first + ioa[1].unpack('H*').first + ioa[0].unpack('H*').first).to_i(16)) + \
                   " VTI: 0x" + response_data[3].unpack('H*').first + " QDS: 0x" + response_data[4].unpack('H*').first)
        response_data = response_data[5..-1]
      end
    end
  end

  def parse_m_dp_tb_1(response_data)
    sq_bit = Integer(response_data[6].unpack('C').first) & 0b10000000
    response_data = response_data[11..-1] # cut out acpi data
    if sq_bit.eql?(0b10000000)
      ioa = response_data[0..3]


   while response_data.length >= 5
        print_good("    IOA: " + String((ioa[2].unpack('H*').first + ioa[1].unpack('H*').first + ioa[0].unpack('H*').first).to_i(16) + i) + \
                   " Value: 0x" + response_data[0..3].unpack('H*').first + " QDS: 0x" + response_data[4].unpack('H*').first)
        response_data = response_data[5..-1]
        i += 1
      end
    else
      while response_data.length >= 8
        ioa = response_data[0..3]
        print_good("    IOA: " + String((ioa[2].unpack('H*').first + ioa[1].unpack('H*').first + ioa[0].unpack('H*').first).to_i(16)) +by the Lookout Emergency Aid Society, for over a decade. The residents of the Cliff Block, who have experienced challenges ranging from mental illness, to addiction, to homelessness, receive support, supervision, and direction from Lookout and the Cliff Block staff. Most importantly, they are given the opportunity to connect with their communities in a meaningful way.

I didn’t know about any of this until September of this year. Coming from Coquitlam, where there is no equivalent to Lookout, I’ve lived my life with a certain amount of distance between myself and places like the Cliff Block. While I was aware that organizations like that existed, I’d always operated under the assumption that they worked autonomously from the communities in which they were situated. That is, until this fall when


to build a powerful, international campaign to prevent Assange’s rendition to the United States and secure his freedom.

John Shipton at the “Candles 4 Assange” event in Berlin

Shipton, who had visited his son just before traveling to Berlin, described the gruesome situation he is facing in Belmarsh.

“Julian was sentenced to 50 weeks in jail for minor infringements in a maximum-security prison in solitary confinement for 22 to 23 hours a day. There is a limitation of visitations which is two social visits for two hours. So those two hours, you can imagine, are very, very precious things. The Belmarsh prison is quite a way out and the requirements of registration are complex. That is his day to day situation.”

Shipton explained that his son has basically no access to anyinformation. “There are restrictions on access to the library, access to the gym and access to computers. So, in order to prepare for his case, he has no access to the library, no access to computers and no access to the internet. He has no access to information at all.”

Due to his deteriorating health—Shipton said his son has lost 15 kilos since his imprisonment in Belmarsh—Assange has been transferred to the hospital ward of the prison.

“There he is still in isolation 23 hours a day but now he can have three visits a week. This is some improvement but still it’s a Grade A maximum-security jail. And Julian is a Grade B prisoner. His health has been declining and has reached a point where he may die. This


Kat has only in the near past moved in together with her model fresh bf and naturally, they’re very into fucking one another like loopy. So when he determined to attempt taking pictures vid of them enjoying Kat was very open to the thought.heated battle to attain such position, is the employer Red Ball still required to deal with each union in accordance with the applicable collective bargaining contract, or in particular, is it required to abide by the provisions of the contracts regarding the processing of employee grievances? To resolve this question concerning the duties and obligations of an employer in such circumstances we look to the NLRA and the interpretative case law.

11
Section 8(a) (5) of the NLRA, 29 U.S.C. § 158(a) (5), makes it an unfair labor practice for an employer to refuse to bargain collectively with the representatives of his employees. This section is subject to the provisions of Section 9(a), 29 U.S.C. § 159(a), which state that the representatives selected for the purposes of collective bargaining by


to bargain with a union which did not represent the majority of the employees in the circumstances presented.7 While we recognize that both the Teamsters and the union in Glendale are not exclusive bargaining representatives, the Teamsters has not been decertified by the Board and the Teamsters does not wish to bargain for a wage increase but only to process employee grievances. Therefore we also find that the principles of Glendale are not controlling.

13
The factual setting of the case before us can be compared to a situation where two unions are sponsoring organizational drives among the same group of employees. In such a situation the employer's duty is one of strict neutrality. Welch Scientific Co. v. NLRB, 340 F.2d 199 (2 Cir. 1965); NLRB v. Burke Oldsmobile, Inc.,Modern Sonic, catapult past perilous platforms as Classic Sonic, and use powerful new gadgets as their own Custom Hero Character. The game will be available for Nintendo Switch, PlayStation 4, Xbox One and PC on November 7. Pre-order the Bonus Editions of Sonic Forces now at www.sonicthehedgehog.com .


are not recommended, because distal fixation of these nails is not reliable.

Before planning a retrograde nail osteosynthesis, it has to be proven that the distal entry point between the condyles of a resurfacing total knee arthroplasty (TKA) is 'open' (Figs. [3](#Fig3){ref-type="fig"} and [4](#Fig4){ref-type="fig"}). In prosthesis with a box (e.g. posteriorly stabilised) or with a stem, a plate should be preferred. According to a recent analysis of the literature, there seems to be no difference in clinical outcome using a nail or a plate \[[@CR15]\].Fig. 3Anteroposterior (**a**) and lateral (**b**) view of a Rorabeck type 2 and OTA 32-B2 fracture around a monolateral TKA in a 77-year-old female patient; by Florian GebhardFig. 4Posoperative anteroposterior (**a**) and lateral (**b**) views after minimally invasive stabilisation with an intramedullary nail (DFN with twistedthe tip of the THA in order to prevent stress raising at the 'inter implant' region. **c** shows the dimension of the needed incisions

Specially designed periprosthetic plates (NCB-PP®; Zimmer®) have a broader metaphyseal area augmenting the possibilities in PPF fixation especially around uncemented implants (Fig. [8c](#Fig8){ref-type="fig"})

### Surgical technique {#Sec12}

Plating may be performed in different techniques of reduction and fixation. Reduction can be achieved either directly (forceps and lag screw/cerclage) in two-part long spiral fractures (OTA Type 32 or 33-A1) or by bridging the fracture zone when direct reduction cannot be achieved (e.g. multi-fragmented fractures). These principles should be respected independently from the selected approach (see below).

Although 'open' techniques allow for direct visualisation of the fracture, impairment of the local bony perfusion after manipulation of the soft tissue is of


96 Ill. App.2d 124 (1968)
238 N.E.2d 182
People of the State of Illinois, Plaintiff-Appellee,
v.
Walter Marshall, Defendant-Appellant.
Gen. No. 52,072.
Illinois Appellate Court  First District, First Division.
May 27, 1968.
*125 Lionel I. Brazen, of Chicago, for appellant.
John J. Stamos, State's Attorney of Cook County, of Chicago (Elmer C. Kissane and James R. Truschke, Assistant State's Attorneys, of counsel), for appellee.
MR. JUSTICE MURPHY delivered the opinion of the court.
In a jury trial, defendant was found guilty of robbery and sentenced to 5 to 12 years in the penitentiary. On appeal defendant complains of trial errors, erroneous instructions, and asserts that his sentence is excessive and should be reduced.
The evidence shows that on the afternoon of April 4, 1966, after boarding a CTA bus, and in the presence of about twenty-five passengers, defendant, inhis person before leaving home. He made several purchases of liquor and beer, which he drank despite his suffering from a liver ailment; that he never threatened to kill the bus driver; that he gave the driver one dollar; and that he was seized with cramps and sought to leave the bus, and took back his own money.
[1, 2] Initially, defendant argues that his mental condition from the combined effects of sickness and heavy drinking was at such a low ebb that the requisite intent *127 to commit a robbery "could well have been absent." Defendant states, "When ignorance or mistake of fact negatives the existence of an intent essential to the commission of an offense the defendant's ignorance or mistake of fact is a defense," and that


fast, like one of those old silent movies where the action’s sped up. And Baxter looks behind him, and he pisses himself — I know, because I smelled it; I can still smell it — and he takes off running.

I wanted to chase him down, but you know what it’s like; it’s a dream, you can’t move, you’re a prehistoric mosquito trapped in amber.

Then this … thing spirits past me. It’s after Baxter, and it’s terrible. I can’t describe it, but every hair on my body stands up just thinking about it. There’s pure horror radiating off of the thing, and it’s all I can do not to piss myself in fear, just like Baxter did. And as it passes me, it lets me see one thing. Itshydrogels of this shape can affect cellular orientation. Thus, E1Y9 hydrogels can potentially be used as artificial ECMs with desirable bioactivities and shapes that could be useful in tissue engineering applications. © 2015 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 106: 476-483, 2016.


of produced $\pi ^{-}$ ($\pi ^{+}$) is about 1.1 (0.38) per event in the central $^{132}$Sn + $^{124}$Sn reaction at 300 MeV/nucleon.

![(Color online) \[delta\] Production of $\Delta$ resonances as a function of time with different x parameters in the reaction of $^{132}$Sn + $^{124}$Sn at a beam energy of 300 MeV/nucleon and an impact parameter of 1 fm.](fig6.eps){width="50.00000%"}

As shown by Eq. (9), pion production is from the decay of $\Delta$ resonance, it is thus necessary to also show the production of different $\Delta$ resonances in $^{132}$Sn + $^{124}$Sn reaction. Fig. \[delta\] shows the production of $\Delta$ resonance as a function of time with different x parameters. It is seen that $\Delta^{-}$ and $\Delta^{++}$ productions are sensitive to the symmetry energy and have opposite effects of the symmetry energy. The symmetryphoton [@yongp1], the other way is to make some kinematic cuts such as the yield ratios of squeezed-out nucleons and pions perpendicular to the reaction plane [@yongso; @gao13].

Shown in Fig. \[ekrpion\] is the $\pi ^{-}/\pi ^{+}$ ratio as a function of pion kinetic energy in central $^{132}\rm {Sn}+^{124}\rm {Sn}$ reaction at 300 MeV/nucleon with (b) and without (a) azimuthal angle ($45^{0} < \varphi < 135^{0}, 225^{0} < \varphi < 315^{0}$ means the direction perpendicular to the reaction plane) cuts. From panel (a), one sees that below 150 MeV kinetic energy, the soft symmetry energy (x = 1) corresponds to a high value of the $\pi ^{-}/\pi ^{+}$ ratio while the stiff symmetry energy (x = 0) corresponds to a low value. Without azimuthal angle cuts, the effects of the


symmetry energy above 1.5 times saturation density are minor. While with the azimuthal angle cuts shown in panel (b), around 50 MeV, the effects of the symmetry energy above 1.5 times saturation density become larger, even play a major role around the Coulomb peak [@ylcz06]. Because the impact parameter in heavy-ion collisions is usually not zero, pions emitted perpendicular to the reaction plane in general have less final strong interactions suffered from low densities. Pions emitted perpendicular to the reaction plane thus more clearly reflect initial pion production at high densities. Therefore, to probe the symmetry energy at maximal density in heavy-ion collisions, it is necessary to make some kinematic cuts for probes that are sensitive to the symmetry energy. From the right panel of Fig. \[ekrpion\], it is1 criteria for the selection of your next investor and/or board member should be: can I answer (with 100% confidence) that my new partner will not destroy value in the firm I created. Here’s why the question makes sense:

The success or failure of your entrepreneurial venture pretty much comes down to you and your team. If you succeed, it’s because you and the team nailed it. Maybe the failure was the result of your own screw-ups. Maybe it was driven by macro events. Either way, it comes down to you. On the other hand, investor impact on your venture is highly asymmetric. If you succeed, your investors may have added some value, but its highly unlikely that the value they added was even close to being among the


in complete control. The remote control is a plug and play system that allows you to start, stop and choose different speeds while in operation. Imagine you are on your SUP cruising along and just using your paddle to steer? Then when you have more energy, you can continue to paddle under your own steam.

The point of SCUBAJET is not to make you lazy while performing a favorite activity on a river, lake or ocean. Yet, to provide you with more fun while operating your water craft and adding a level of safety. The jet engine gives you the flexibility to add another dimension to the outdoors and increase your level of excitement while on or in the water. There are times when you will want to shutsuch a compound which has acceptable activity and which is also capable of contacting the virus infection in effective concentrations makes this task exceedingly difficult.
In German Patent Application No. 2,047,368, 9-.beta.-D-arabinofuranosyladenine-5'-phosphate is suggested as a compound useful as an antiviral agent. This compound, however, as an AMP analog and a precursor to an ATP analog is rapidly degraded in the metabolic system (eventually to uric acid). Since ATP levels in the metabolic system are carefully maintained by the metabolic system at low levels the effectiveness of such compounds as antiviral agents is accordingly diminished.
In view of the foregoing, we thus sought to prepare additional nucleosidic analogs in order to investigate the possibilities that certain such compounds might be capable of withstanding rapid metabolic degradation and also penetrating the


Has anyone heard about this? What do you all think (even considering the source)?

The only thing I've heard about this is from a linguistic standpoint: in the Early Church when Latin priests and monks traveled to what is now England to convert the pagans residing there, linguistically they opted rather to use concepts and terms already existing in the vernacular Anglo-Saxon tongue, instead of teaching this new faith using foreign Latin words that would alienate the natives. As such, rather than using the Latin "Pascha" for the celebration of Christ's resurrection (which is theologically more accurate of course because it ties Christ to the Paschal Lamb, etc.), the missionaries chose instead to "baptise" the local customs and the term for their annual spring fertility celebration, which was incontains a name, and value. The row also contains a
    type or mimetype. Type corresponds to a .NET class that support
    text/value conversion through the TypeConverter architecture.
    Classes that don't support this are serialized and stored with the
    mimetype set.

    The mimetype is used for serialized objects, and tells the
    ResXResourceReader how to depersist the object. This is currently not
    extensible. For a given mimetype the value must be set accordingly:

    Note - application/x-microsoft.net.object.binary.base64 is the format
    that the ResXResourceWriter will generate, however the reader can


is used less and less, there is a concrete possibility of this renal condition being forgotten in the future. Although the pathogenesis of MSK has yet to be elucidated, its association with different malformative conditions supports the idea that it is a developmental disorder. Recent findings suggest that MSK may be the consequence of a disruption of the ureteral-bud/metanephric-blastema interface.INTRODUCTION
============

Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), is a major cause of morbidity and mortality in hospitalized patients. PE is the third most common fatal vascular disorder following coronary artery disease and cerebrovascular accident ([@B1]); it is also the leading cause of preventable hospital death and a major cause of maternal mortality ([@B2], [@B3]). In addition to the clinical impact of VTE on morbidity and mortality, the economic burden of the disease is considerable ([@B4]). Thus, VTE is a major public health concern in developed countries.

For the treatment of VTE, thromboprophylaxis has been recommended based on the four following factors: the high incidence of VTE in hospitalized patients; the difficulty of early diagnosis due to vague symptomatology; the cost-effectiveness of medical prophylaxis;


repeated insertion attempts, concomitant anticoagulation, continuous use of epidural catheters, and old age ([@B29], [@B30]).

We recommend against concomitant administration of medications affecting hemostasis, such as antiplatelet drugs or warfarin, during anticoagulation with LMWH or UFH (Grade 1B). The presence of blood during needle and catheter placement does not necessitate postponement of surgery. We suggest that initiation of LMWH therapy in this setting should be delayed for 24 hr postoperatively and that this consideration be discussed with the surgeon (Grade 2C). For patients receiving prophylactic doses of LMWH, we recommend a delay of at least 10-12 hr after the time of needle insertion (Grade 1C). For patients receiving therapeutic doses of LMWH, we recommend a delay of at least 24 hr before the time of needle insertion (Grade 1C).The Electoral Reform Society (ERS) has written to party leaders calling for cross-party talks on how campaign regulations can be updated in light of the Cambridge Analytica revelations.

The campaigners are also urging the Electoral Commission and Information Commissioner to set out what powers and resources they need to monitor the online campaigning landscape, which the ERS describe as a ‘wild west’.

The main legislation regulating political parties’ campaigning activity and finance dates back to 2000 – before Facebook (public in 2006) or Twitter (2006) even existed, let alone had any role in political campaigns.

The campaigners note that the Political Parties, Elections and Referendums Act (PPERA) – the main act covering election law – was written in a time of ‘mini-discs and the millennium bug, with today’s online minefield far


to see what is being done with our data.

“In the instance of Cambridge Analytica, it appears that this went beyond usual practice – and there are clearly some very big questions to answer.

“Both social media giants and our politicians look like they’ve been asleep at the wheel while unscrupulous agencies harvest our most personal information for political and financial ends.

“We are witnessing a massive concentration of power beyond even the normal huge inequalities in our democracy. We need to bring our regulations as well as transparency and scrutiny into the 21st century.

“It’s now time for a root-and-branch review of campaigning rules and enforcement.

“How to do that will need to come from civil society, the Information Commissioner and the Electoral Commission – and it might also require new powersthe business opportunity.

------
corin_
I was channel surfing on TV yesterday and flicked onto one of the Harry Potter
films, to hear Hermione saying she researched something in the library and
couldn't find a single reference - my immediate thought before moving on a
channel was that (assuming I don't have her magical skills), I would have no
idea how to research something in a library without either the internet, or
asking other people who might know where I could find the answers.

(I say no idea - obviously on a basic level it wouldn't be hard to start by
finding all books on the rough topic, reading them, etc.... but to do it with
any sort of efficiency as opposed to so slowly that I'd end up beating myself
to death with a hardcover.)

~~~
slantyyz
That's a fascinating perspective.

When I


That airplane shaking uncontrollably in the sky is not CGI or a model airplane. It's a real Tupolev Tu-154, a three-engine jet designed in the Soviet Union during the mid-sixties. If you are scared of flying, don't watch this video.

Apparently, the airplane's control surfaces went completely bonkers right after taking off from Chkalovsky airfield, but somehow the pilots managed to guide it back to Earth in one piece. Being inside that flying cocktail shaker must have been a complete nightmare—absolutely terrible situation and amazing job by the pilots.

According to the YouTube description, the airplane was back in the air for a test at the end of March, after 10 years in storage. Russian Aeroflot retired the Tu-154—the backbone of their fleet for three decades—in 2010. Coincidentally, the RussianAuthor Archive for rebekah

I know that everyone in the world right now is freaking out about the Doug Philips scandal, and to be honest, the whole thing grosses me out so much that I don’t even want to read about it. And given that I don’t even want to read about it, I’m certainly not going to pull up my socks and start writing about it. But the whole situation has given me some food for thought, and that is on the question of how to raise our daughters so that they don’t fall prey to the manipulations of that kind of man – because those kind of men are found the world over, not merely in patriarchal conservative groups. Is your daughter ever likely to encounter more


---
abstract: 'The basic Kriging’s model assumes a Gaussian distribution with stationary mean and stationary variance. In such a setting, the joint distribution of the spatial process is characterized by the common variance and the correlation matrix or, equivalently, by the common variance and the variogram matrix. We discuss in in detail the option to actually use the variogram as a parameterization.'
address: 'G.Pistone: de Castro Statistics, Collegio Carlo Alberto, Via Real Collegio 30, 10024 Moncalieri, Italy (E-mail: [giovanni.pistone@carloalberto.org]{}). G. Vicario: DISMA [*Luigi Lagrange*]{}, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10124 Torino, Italy (E-mail: [grazia.vicario@polito.it]{}) '
author:
- Giovanni Pistone
- Grazia Vicario
title: 'How to model the covariance structure in a spatial framework: variogram or correlation function?'
---

Introduction
============

The present note is a development of the Author’s paper . An application was implementedare unrestricted values of $\mu \in \reals, \sigma^2 > 0$, and restricted values of $R$ that are usually estimated over a suitable parametric model.

2.  Krige’s idea is to predict the value $Y_0=Y_{x_0}$ at an untried location $x_0$ with the conditional expectation based on a plug-in estimate of the parameters. If $I = \set{1,\dots,n}$ and the locations in the model are $x_0,x_1,\dots,x_n$, the regression value is $$\widehat{Y_0 - \mu} = \Sigma_{0,I} \Sigma_{I,I}^{-1} (Y_I - \mu \one_I)
      , \quad \text{with} \quad  \Sigma = \begin{bmatrix} \Sigma_{I,I} & \Sigma_{I,0} \\ \Sigma_{0,I} & \sigma^2 \ .
        \end{bmatrix}$$ The set of data that give the same prediction is an affine plane in $\reals^n$. The variance of the prediction is $\sigma^2_0


\one\one'$, such extreme case being always excluded in the following. In fact, in most cases we will assume $\det R \ne 0$.

The entries of $\Gamma$ are nonnegative and bounded by $2\sigma^2$ because the correlations are bounded between $-1$ and $1$. If all the correlations are nonnegative, the the entries of $\Gamma$ are bounded by $\sigma^2$.

The difference between the covariance matrix and the variogram matrix is a matrix of rank 1, $\Gamma + \Sigma =  \sigma^2 \one\one'$. Let us remark moreover that $$\label{eq:negdef}
\frac1n \one\one' = \frac1{n\sigma^2} (\Gamma + \Sigma)$$ is the orthogonal projector on the space of constant vectors $\spanof{\one}$.

We denote by $\mathbb S_=$ the cone of nonnegative definite matrices with constant diagonal, by $\mathbb S_{=1}$ the convex set of correlation matrices, and by $\mathbb V$ the cone3000 good Yazar videos Resisting in limited society from 0-3500 that files CAN and WANT to forecast. An difficult, superb text for all marks. believe how you can be download Fermat enfin demontre for all of your competitors.

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A key observation in [@gionis2013opinion] is that the opinion vector at the equilibrium can be computed by performing the following absorbing random walk on the graph $H$. To determine the expressed opinion of node $i \in V$, we start a random walk from $i$; with probability $1 - \alpha_i$ we follow an incident edge chosen uniformly at random from $E$, and with probability $\alpha_i$ we follow the edge from $i$ to $\sigma(i)$, ending the walk. If the walk continues to a node $j$, we perform the same type of step — chosing an edge of $E$ incident to $j$ with probability $1 - \alpha_j$, and moving to $\sigma(j)$ with probability $\alpha_j$ — and iterate. It is shown in [@gionis2013opinion] that this walk represents


adopted to the opinion minimization case. Suppose we have a solution for the opinion maximization problem such that $\alpha_i$ lies strictly between $\ell_i$ and $u_i$. We wish to show that setting $\alpha_i$ to be either $\ell_i$ or $u_i$ will yield a sum of expressed opinions that is at least as large. Proceeding in this way one node at a time, we will get a solution in which all $\alpha_i$ are either $\ell_i$ or $u_i$.

By solving Equation  for $z_i^*$ we obtain, $$\label{eq:combination}
z_i^*  = \frac{\alpha_i}{ 1-(1-\alpha_i)p_{ii}} s_i + \frac{(1-\alpha_i)(1-p_{ii})}{ 1-(1-\alpha_i)p_{ii}} y_i.$$ Therefore $z_i^*$ is the convex combination of two probabilities $s_i, y_i$. Since we wish to maximize $z_i^*$, if $s_i
\leq y_i$ we need to minimize $\dfrac{\alpha_i}{ 1-(1-\alpha_i)p_{ii}}
$; otherwise we will minimize $\dfrac{(1-\alpha_i)(1-p_{ii})}{
1-(1-\alpha_i)p_{ii}}$. Note that the function $g(x) =
\dfrac{x}{1-(1-x)p_{ii}}$ forsatisfies, $$\frac{1}{u}\leq y_{ii} \leq \frac{1}{\ell}.$$ Therefore, $Y \in \mathcal{K}$, which implies the claim.

\[psd\] All eigenvalues of matrix $Z = (X - (X-I)P), X \in \mathcal{K}$ are strictly positive reals (in general $Z$ is not symmetric). Furthermore, $Z$ is positive definite, i.e., for any $y \in {\mathbb{R}}^n$ the quadratic form $y^T Z y$ is non-negative.

Notice that the above two statements are not simultaneously true for non-symmetric matrices: a non-symmetric matrix with all eigenvalues positive is not necessarily positive definite. On the other hand, if a non-symmetric matrix is positive definite, all its eigenvalues have to be positive.

First we prove that all eigenvalues are real. We provide a sequence of similarity transformations that prove $Z = (X-(X-I)P)$ is similar to a symmetric matrix. To simplify notation, when $U = R^{-1}


A R$, where $R$ is a diagonal matrix, we write $U \equiv A$.

$$\begin{aligned}
X - (X-I)P &\equiv X-D^{+\tfrac{1}{2}} {\left(}{  (X-I) D^{-1}A } {\right)}D^{-\frac{1}{2}}  \\
&= X-  (X-I) D^{-\frac{1}{2}}AD^{-\frac{1}{2}}
   \\
&\equiv X-  (X-I)^{-\frac{1}{2}} (X-I) D^{-\frac{1}{2}}AD^{-\frac{1}{2}}   (X-I)^{+\frac{1}{2}}   \\
&=X-  (X-I)^{+\frac{1}{2}}   D^{-\frac{1}{2}}AD^{-\frac{1}{2}}   (X-I)^{+\frac{1}{2}}
 \end{aligned}$$

Since the adjacency matrix $A$ is symmetric, the latter matrix is also symmetric, and therefore has real eigenvalues.

To show all eigenvalues are positive, we invoke the Gershgorin circle theorem. Notice that $Z_{ii}=x_{ii}$ (under our assumption that the graph is simple) and the sum of non-diagonal entries in row $i$ is $-(x_{ii}-1)$. Therefore, every eigenvalue of $Z$ lies in at least one of the Gershgorin discs: $$\begin{aligned}
 |\lambda - x_{ii}| \leq (x_{ii}-1) &\Leftrightarrowin polynomial time.

We can use off-the-shelf interior point methods for convex optimization, see [@boydbook Chapter 11]. To conclude the proof of Theorem \[thm:main\], we need to prove that our objective can be brought in the quadratic form of Corollary \[maincor\].

For simplicity, let $Z=(X-(X-I)P)$. We consider the quadratic,

$$\begin{aligned}
(s+ \vec{1})^T   Z^{-1} (s+ \vec{1}) &= s^TZ^{-1} s + \vec{1}^T Z^{-1} \vec{1}+
 \vec{1}^T Z^{-1} s +
s^T Z^{-1} \vec{1} \\
 &=s^TZ^{-1} s + n + \vec{1}^T Z^{-1} s + s^T \vec{1} \Leftrightarrow\\
 \vec{1}^T Z^{-1} s &= (s+ \vec{1})^T   Z^{-1} (s+ \vec{1}) - s^TZ^{-1} s  - C \\
 &=  \langle \underbrace{  (s+ \vec{1}) (s+ \vec{1})^T   - ss^T}_{Q}, Z^{-1} \rangle - C, \end{aligned}$$

where $C=n+\sum\limits_{i=1}^n s_i$ is a constant that does not depend on


\emptyset$, and $x = \{3\}$. Then, supermodularity would require that

$$f(3) - f(\emptyset)  \leq f(1, 3)  - f(1),$$

the left-hand side of the inequality is 1.493 and the right-hand side is 0.168.

Hence, our objective function is neither submodular nor supermodular in the target set.

Highlighting a difference with the unbudgeted version, we show that Problems \[probmax\], and \[probmin\] are [[$\mathbf{NP}$-hard]{}]{}by a reduction from the vertex cover problem on $d$-regular graphs. To prove this, we adapt a construction for a different opinion maximization problem given by [@gionis2013opinion] in the context of their model. We only present the proof for the opinion maximization problem; as the example above, the proof can easily be adapted for opinion minimization as well.

The budgeted opinion maximization (and similarily opinion minimization) problem is [[$\mathbf{NP}$-hard]{}]{}.

Given a $d$-regular graph$\theta'$ denote the middle term in this chain of inequalities; we have thus shown that if $G$ does not have a $k$-node vertex cover, then for any set $T$ of at most $k$ nodes, we have $f(T) \leq \theta' < \theta$.

What remains to show is there exists an optimal target-set that consists of only nodes in $V$ and not in $V'$, where we assume that this target-set is at most of size $k \leq n$ for $n = |V|$. Denote the optimal target-set in by $T^*$. Suppose there is a node $i' \in T$ which is a node in $V'$. Let $i'$ be adjacent to a node $i \in V$. If $i'$ is a flexible duplicate node, then it is clear that the expressed opinions of both $i'$


368 F.Supp. 817 (1974)
Jerry K. FORBES, Plaintiff,
v.
Lucille ROEBUCK, Individually and in her official capacity as Chairman of the Kentucky Board of Pardons and Paroles, et al., Defendants.
No. 432.
United States District Court, E. D. Kentucky, Frankfort Division.
January 14, 1974.
*818 Jerry K. Forbes, pro se, Dean Hill Rivkin, Scott T. Wendelsdorf, Lexington, Ky., for plaintiff.
Bruce K. Davis, Dept. of Corrections, Frankfort, Ky., for defendants.

MEMORANDUM
SWINFORD, District Judge.
This action initiated by a re-incarcerated parolee questions Kentucky's compliance with the procedures for parole revocation decreed in Morrissey v. Brewer, 408 U.S. 471, 92 S.Ct. 2593, 33 L.Ed.2d 484 (1972). The petitioners in that case were returned to prison without hearing following an administrative determination that violations of parole conditions had occurred. The Court's lengthy discussion of the origins and philosophy of the nation'sscale a mountain?" "Lose my virginity." "Hold on a second..." "You were going to lose your virginity to" "Matthew Sobvechik in 11B at Ween Dormitory?" "He's the TA in my pre-med bio class." "I'm deliberately failing to get work sessions with him." "We fool around after he teaches me things I already know." "Jesus..." "How Matthew Sobvechik managed to bag such a delightfully unhinged hottie, by being the most boring fucking guy on this entire floor is beyond me." "Well, I'm in love with him." "Come on, there's no way you love Matthew Sobvechik, the Pontiac Aztec of people." "Lainey, you having sex with Matthew Sobvechik is basically the same thing as me telling an Aborigine in the Australian outback that he's about to listen to the Beatles


be ready." " You ready?" " Yes." "Sex is like... kissing with your entire body." "Very sensual experience." "It's like shooting heroin in a controlled yet moist environment." "You know?" "You know what it's like - it's like Times Square at night." "I mean just the right tinge of danger." "Oh my god." "What?" "Yeah?" "Yeah, yeah, yeah." "Okay." "Yeah." "So I haven't technically..." " actually..." "really done it yet..." "Why are you laughing at me?" "That's not" "But you're so old!" "Fuck you!" "I didn't call you an old virgin!" "I'm shocked." "I'm shocked." "You're so cute." "Why are you giving me shit?" "You can't get the most boring dude in our dorm to sleep with you." "You know, that's ridiculous." "You're the one who should be"a liar." "You're such a piece of sh" " Hey second second point." "Okay?" "If you really, actually wanted monogamy, why have casual sex with me for three months?" "I mean, if you want to grow flowers, you don't plant them in a closet." "So either you're stupid or deep down inside you don't want monogamy either." "You fucked my best friend!" "Which brings me to my third and final point." "Your chief complaint is not that I screwed someone; it is who I screwed." "That's what it's about, right?" "So much like the counter-intuitive plan to secure an exclusive relationship with a guy that you don't actually want to date - moi, your issue with me and Sarah" " Do not say her name!" " Your issue


Here's the thing, guys." "I don't negotiate, but my lawyers do." "So if you want to reopen the terms of the contract that's fine, I'm just going to go grab some lunch." "Alright." "Alright." "Alright." "Okay." "You don't have to go for lunch yet." "Okay" "Congrats, boys." "You have officially sold out." "Fuck yes!" "Oh my god!" "I really thought you were going to fuck this up." " Me too." " I really did." "He fucks everything in life up." "I have two beautiful children, both are gonna have ridiculously terrible teeth; so you're getting braces, you're getting braces, you're getting braces!" "Hey." "You going to lunch?" "Can I come with?" "Dinner maybe?" "How about brunch with my folks, you'll love them." "You're smart, handsome and now haveand now you're a pod person." "But maybe if I don't have any sex..." "And become sexually anorexic?" "No." "What?" "Is that a real thing?" "Yeah, of course it's a real thing." "Sexual anorexia." "It's like depriving yourself of sex because of low self-esteem, or abuse or other gnarly shit." " That's great." "That's another dysfunction I have to worry about developing." "It's like enough with this shit." "It's over, Jack." "It's like enough!" "I mean, you can do so much better." "I don't care if it's a woman or if it's somebody else, just anything but the schmuck." "I feel like people are looking at us." "The guy I lost my virginity to was at my sex addicts meeting." "What do you think that means?" "It's a


yes, so you're going to go after the cervix here." "So you're going to mind the gap, right." "And tap the roof." "Mind the gap." "Tap the roof." " You got it." "And at this point you want to start thinking about something arousing." "You know, like maybe you want to think about the guy you lost your virginity to perhaps." "Gross." "Okay, and then you're going to start to get wet." "You're going to start to get wet and then you're going to start to feel some contractions in your vagina." "At that point you're going to want to squeeze your vagina harder than it wants to go, okay." " And that's called" " Kegeling." "Well it's pronounced kee -gul -ing, but it doesn't matter." "Uh, I"It's the 21st century." "We know that's not true." "You and I are friends." "Sex doesn't get in the way of our friendship." "I'm not attracted to you." "And I have zero penises." "I am." "Hi, George." "Hi, it's me." "Your girlfriend." "I like bad girls with Daddy issues." " She's twenty-two, she'll fuck anyone." "Wait." "I'm sorry, no." "Serious, she's probably fucked everyone in here but I don't even care." "You got a minute?" "Not really." "I'm kind of in the middle of something." "I was thinking..." "Oh yeah?" "Do you wanna come to Henry's birthday party this weekend?" "Really?" " Yep." "Xander, in the eight years I've known you as a father you have never once invited me to any function involving your children." "Hear me


be kinda cool though if you could just hang onto the back." "Eddie Murphy at the beginning of Beverly Hills Cop?" "Remember that?" "Cigarette truck - never mind." "Alright." "Drive safe." " Go." " Bye." "Go be a hot shot." "Hi babe, it's me." "Um..." "I hope the goodbye went well." "Oliver and I are on our way." "Okay, see you soon." "Nice job, Oliver." "You're a whirling dervish out there." " A whirling dervish!" " You got this, Henry." " There you go, Henry." "Right through." "How's that feel, blue?" "How's that feel, blue?" " Yeah, little legs but they move fast." "Get it." "Get it." "Reverse it." "Reverse it." "Yeah!" " Yes!" "Nice pass, man." " Get off me!" "Sorry, I'm just a passionate fan man."" We gotta do it now, yeah." "But we got to do it quick." "Call Xander, tell him we're gonna be late." " Absolutely..." "How long shall I tell him we're going to be?" "A couple of hours." "Really?" "Luck guy, aren't I." " Yeah, and then we'll still go and get married." " Absolutely." "Whoa, whoa, whoa." "I forgot something." "What?" "That." "Yeah." "Better, right?" "So we got twenty blocks." " Why didn't we just take the bus?" "Oh that's a good point." "Should we get on the bus?" "I wonder if we can find that route where we first did it." "Oh, you're such a romantic." "Yeah, yeah...." "I love you." "I love you too." "Yeah. we'll be here." "Okay, have fun I dunno." "Okay, bye."


not even music." "Really?" "There's music in my body." " Okay, now something's happening." "Let's get out of here." "Let's go back to the hotel." "I want to do stuff to your body." "Upstairs." "Downstairs." "Right?" "Yeah." "All right." "I love you, honey." "I love you." "Let's go!"loads. He can also tell they are moving quickly. They are not yet running, but they are moving as fast as their heavy loads permit. One is not carrying a heavy load. The Shadow Wolf knows this person is the group¡¯s leader.

The Shadow Wolf increases his own speed across the dry, hot desert. Soon, he can tell that the five men are running. They know he is following them.

Moments later, in the far distance, a group of birds suddenly flies away from the ground. The five men have frightened the birds. The Shadow Wolf slowly pulls out his radio and calls for help.

The five men are captured within an hour. They are arrested for trying to bring illegal drugs into the United States. Once again, the Shadow Wolf


Tohono O¡¯Odham Reservation. It is a few kilometers west of the city of Tucson, in the southwestern state of Arizona.

The huge reservation shares a one-hundred-twenty-kilometer border with Mexico. People who want to sell illegal drugs in the United States carry the drugs on their backs across the desert land of the Tohono O¡¯odham Reservation. They try to move from the border to the nearest road, about forty kilometers away. Usually about three or four people carry the drugs through the reservation at night. Their shoes leave marks in the dirt.

The Shadow Wolves follow these shoe marks to find the drug dealers and arrest them. The Shadow Wolves have been very successful at this.

VOICE ONE:

The Congress of the United States approved the idea of the Shadow Wolves thirty yearsweapons. Shots have been fired more than once.

Each of the Shadow Wolves wears a small gray colored feather on his clothing. It reminds them that their work can be dangerous. It also honors Shadow Wolf Glenn Miles. He was shot and killed by illegal drug dealers in nineteen-eighty-seven. The person responsible for the crime was never caught.

Several of the Shadow Wolves followed the killer. The signs he left on the ground crossed the Mexican border nine kilometers from where the shooting took place.

VOICE ONE:

Each month, the Shadow Wolves find hundreds of kilograms of illegal drugs and arrest those carrying the drugs. The group knows it will never catch all the criminals who try to move illegal drugs through their area. However, the Shadow Wolves will continue to prove


it does, then we found the unique solution. If not, there is no solution.
You could find the general solution to the $2$x$4$-system by parameterising, but it is easier to just plug in the known $4$x$4$-solution.

Increased 18F-FDG uptake of widespread endometriosis mimicking ovarian malignancy.
Endometriosis is a benign disease characterized by the implantation of functional endometrial tissue in ectopic locations. We present a case of a 42-year-old woman with widespread endometriosis that mimicked ovarian malignancy on FDG PET/CT. Increased FDG uptake was observed not only in the right ovary, but also in the liver capsule, perihepatic nodules, greater omentum, and the mesentery. This case indicates that widespread endometriosis may be a cause of multiple FDG uptakes in women of reproductive age and should always be kept in mind in the differential diagnoses of suspicious malignancy.


"store", DataSpace.CSpace, new EdmFunctionPayload { IsComposable = true }),
                        null,
                        new EntityContainerMapping())).ParamName);
        }

        [Fact]
        public void Can_not_create_composable_function_import_mapping_with_null_container_mapping()
        {
            Assert.Equal(
                "containerMapping",
             Strings.NonComposableFunctionCannotBeMappedAsComposable("functionImport"),
                Assert.Throws<ArgumentException>(
                    () => new FunctionImportMappingComposable(
                        new EdmFunction("f", "entityModel", DataSpace.CSpace, new EdmFunctionPayload { IsComposable = false }),
                        new EdmFunction("f", "store", DataSpace.CSpace, new EdmFunctionPayload { IsComposable = true }),


          complexType,
                new Collection<FunctionImportReturnTypePropertyMapping>()
                {
                    new FunctionImportReturnTypeScalarPropertyMapping("P1", "C1"),
                    new FunctionImportReturnTypeScalarPropertyMapping("P2", "C2"),
                });

            var resultMapping = new FunctionImportResultMapping();
        After the Cliff Lee trade blew up, many fans thought the Yankees and Mariners would never do business again. Not only have Brian Cashman and Jack Zduriencik forgotten their grievances, but they've become extremely active trade partners. Over the last year and a half, the two teams have made three major trades, sending Jesus Montero and Hector Noesi to the Mariners for Michael Pineda and Jose Campos, swapping D.J. Mitchell and Danny Farquhar for Ichiro Suzuki, and sending Abraham Almonte to Seattle for Shawn Kelley. As the Mariners are yet again in the position to sell, it wouldn't be surprising to see Brian Cashman knock on Zduriencik's door to see what's available.

The Mariners have a few free agents to be that likely wouldn't receive qualifying offers, and thus


tax cuts. The tax debate was the most closely followed story for 7%; about two-in-ten (21%) say they followed this story very closely.

While 11% say they followed news about the elections most closely, the same percentage say they followed news about the release of a jailed American hiker held in Iran that closely. Nearly a quarter (23%) say they followed election news very closely, while 16% say they followed news about the released hiker that closely. Her release accounted for 2% of coverage.

Another 4% say they followed news about Israeli-Palestinian peace talks most closely, while 13% say they followed this news very closely. The talks accounted for 1% of coverage.

And 4% say
they most closely followed the visit by Pope Benedict to Great Britain and his comments on theinterest in the top news stories of the week were collected September 16-19, from a nationally representative sample of 1,005 adults.

About the News Interest Index

The News Interest Index is a weekly survey conducted by the Pew Research Center for the People & the Press aimed at gauging the public’s interest in and reaction to major news events. This project has been undertaken in conjunction with the Project for Excellence in Journalism’s News Coverage Index, an ongoing content analysis of the news. The News Coverage Index catalogues the news from top news organizations across five major sectors of the media: newspapers, network television, cable television, radio and the internet. Each week (from Monday through Sunday) PEJ compiles this data to identify the top stories for the week. (For more


are allowed, they would never get referenced by new transaction.

For most of the proposed use cases by IOTA, a smart contract cryptocurrency would be a huge advantage. Thus I strongly believe that once a scalable cryptocurrency releases that implements this (Maybe a shardable Ethereum/EOS), they can pop IOTA out of the market without having to blink twice.

The Good

A great experiment

IOTA is the first cryptocurrency that implements the Tangle concept. The tangle is interesting in many ways, for one it being more scalable: The IOTA foundation is partnering with universities to do simulations of more saturated IOTA networks, to see how the tangle natively shards. With a little luck the tangle will shard easily thanks to Swarm Intelligence, where each node only knows a small fraction of the tangle,mess because he merely strengthened public perception that he was only trying to punch holes in an airtight case.

Let me address the defenses raised by Celiz and Tabud one by one.

First, while public funds were not involved, and the transaction was by and between private corporations, there is still the primordial public interest that’s at stake. The transactions of private corporations are not beyond the scrutiny of media and regulators like the Securities and Exchange Commission (SEC). And contrary to what Celiz wanted to purvey, the officers of corporations can be held accountable for any misfeasance or malfeasance.

What happened in the swindle of the UPS funds is a classic case of corporate fraud. And Mabilog, as the chief financial officer of the HALIGI Foundation, is right at the


Combinatorial pattern discovery in biological sequences: The TEIRESIAS algorithm.
The discovery of motifs in biological sequences is an important problem. This paper presents a new algorithm for the discovery of rigid patterns (motifs) in biological sequences. Our method is combinatorial in nature and able to produce all patterns that appear in at least a (user-defined) minimum number of sequences, yet it manages to be very efficient by avoiding the enumeration of the entire pattern space. Furthermore, the reported patterns are maximal: any reported pattern cannot be made more specific and still keep on appearing at the exact same positions within the input sequences. The effectiveness of the proposed approach is showcased on a number of test cases which aim to: (i) validate the approach through the discovery of previouslyto Agent Carter was how apt, appropriate and relative it was. Despite being set in the 1940s, much of the message felt rather familiar. As Peggy battled daily to be taken seriously, to do something right, and to live her own life, she was continually undermined and ridiculed. Despite her amazing abilities as an agent, she just could not break that glass ceiling.

One episode I found to be particularly poignant in subtly reflecting the portrayal of women was in the second episode, throughout which the popular radio show: The Captain America Adventure Program was frequently ‘aired’. In it, Betty Carver (Peggy’s pop-culture portrayal) was a weak, whimpering woman: the damsel in distress the media so often enjoys portraying ladies as being. However, during one broadcast, as Captain America


             while($row = $STH->fetch()) {

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                        // Then make our freshor advocating for any type of violence whatsoever, so we felt we really had no choice at that point. She and I were very close, and it was a painful experience, but I don’t think we did the wrong thing.

Where does the money come from? Who bankrolls the Satanic Temple?

In all this time, even I, in my pessimism, have been thinking that any moment now we’re going to get that old, rich benefactor that sees how much we’ve done, and how effective we’ve been with so low of a budget—because we really do things on no budget at all. We crowdfund for these things, have consistent small-scale donations coming in, and our merchandise sells well, but that’s it. It’s genuinely grassroots right now. But I gotta tell ya:


I have no shame in saying that I hope that turns around, and some big benefactors step up and say, “I’m throwing in with these guys,” because I think they’ll see that we’ll put all those finances into the mission, even while we’re scraping by to pay our rent. That’s how much we believe.

You did get some money from Netflix, right? Due to the lawsuit over the unlawful use of the Baphomet statue in The Chilling Adventures of Sabrina?

I can’t confirm or deny that. We do have the rights to the Baphomet monument, a design we made. But that’s really as much as I can say about it. All I can say is that, with settlements, that’s… how they work.

“ Your protest should be supplementing some kind ofSatanic Temple doesn’t make long-term alliances with other organizations. We’ve seen so many of them fold under the pressure of faddish politics and go off in different directions that seem to undermine the very missions that they first set out to confront.

I think the Satanic Temple has stayed very on target during some of this political faddism that has started as a response to the Trump administration. What makes me pessimistic now is the rejection of nonviolent protest—we see a lot more talk now that we need to punch our opposition—and a lot of talk related to free speech, and how we need to regulate offensive speech and target certain kinds of speech. It becomes a very difficult conversation because people feel, and they’ve expressed this to me


handle is moved toward the front or rear of the board, the control disk projects into the snow beneath the board causing a braking effect. Thus, with this invention a user can steer and brake simultaneously by using a simple vertical handle. Use of a single vertical handle to perform both steering and braking functions makes the invention easier, more efficient and more fun to use than prior art devices.
2. The Background Art
In the prior art, there have been numerous devices which a user can ride down a snowy or icy surface. The most popular of these include skis and snowboards. There has also been some work done concerning devices which a user would ride in a standing position and which have a handle for the user toit that they have abandoned their plans.

Labour

Labour’s support remains steadfast but not without a few indiscreet words slipping out at Labour conference on subsidies and public consultations. Labour’s love-in with the nuclear industry continued at a fringe event at the party conference in Liverpool, though not without some indiscreet words slipping out. Public consultations on the building of new nuclear power stations are required by law, but would not cause problems in getting them built, Alan Raymant, COO of Horizon Nuclear Power said. “As a developer we are not obliged to follow the results of the public consultation. But we have to take it into account and explain why we have not include its recommendations,” he said. Horizon is the joint venture of E.on and RWE npower looking


well-off the hardest.

Europe

British households could be forced to subsidise the home improvements of their continental counterparts under controversial plans being drawn up by the European Commission. The proposal – part of an EU energy efficiency drive – could add up to £60 a year to household energy bills, adding to the strain on families that are already facing rocketing gas and electricity prices. The Commission has drafted a new legal requirement for energy companies operating in each member state to cut the amount of electricity and gas they sell by 1.5 per cent each year until 2020. The Commission has set a target of cutting energy consumption by 20 per cent across the EU. The Times has learnt that, under one proposal, companies would be able to meetthe creation of the funding framework have created a breathing space for Japan to rethink its approach to the energy sector. There is no reason to assume that Tepco in its current form needs to be part of that sector. Tokyo will still need electricity, but that does not mean it will still need Tokyo Electric.

Iran

IF IT’S TRUE that Iran is just six months away from producing a nuclear weapon with enriched uranium from its IR-2 centrifuges, then we may just be weeks away from an Israeli attack on Iranian nuclear installations. According to what looks like a deliberate leak from the US government, President Obama agreed in 2009 to the delivery of fifty-five GBU-28 (Guided Bomb Unit) bunker-busting bombs to the Israeli air force. Some have seen


which are bringing jobs and investment to Scotland, and underpinning our position as a location of choice for clean-tech development.” Mr Salmond continued: “I am confident that these very welcome developments are a sign of greater things to come, with much more investment and many thousands jobs expected to be created as we move towards our 2020 vision for renewables.”

Nuclear Costs

Building nuclear power plants can be expensive for investors and customers, adding significant risks to utility stocks generally used as a haven for retirees, widows and others wanting investments with financial stability. A new study released this month by the Texas Institute found a 70 percent certainty that the utility would see its borrowing costs rise due to the downgrading of its credit rating once construction began. Theleft home via the internet, using technology from a company backed by British Gas. AlertMe has formed a joint venture with Invensys, which makes thermostats and heating controls for boilers. The company, which is run by Mary Turner, the former boss of the broadband business Tiscali UK, is providing technology that allows customers to control their thermostats and boiler timer from a remote computer or a smartphone.

Hinkley

EDF and Somerset County Council have shot down anti-nuclear campaigners claims that the energy giant has broken a time limit condition requiring it to remove a spoil heap from the Hinkley Point site by the end of last month. Campaign group Stop Hinkley accused EDF of failing to remove spoil contaminated with asbestos left over from the construction of the original Hinkley


because of its safety record, but as a doubter that its economics make much commercial sense. Nevertheless, if there was a UK government intention that up to ten new nuclear plants should be built to replace the ageing existing fleet, he took the view that it was a game that SSE should be in to maintain a diverse portfolio of electricity sources – currently hydro, onshore and offshore wind, gas and coal. Even earlier this year, he was of the view that the disaster which struck the Fukushima plant in Japan after the M arch earthquake and tidal wave would cause no more than a year’s delay in the UK and European building programme. That he was saying this then indicates that his apparent change of mind andwill mean much less money available for new small-scale renewable electricity installations next year and in subsequent years up to 2015, when the current government spending period is due to end. The prospective funding drought has become a serious worry for renewable energy companies, Sowden said.

Letter Scottish Renewables: It would seem the Liberal Democrat MSP, Tavish Scott, has not been listening to his own party. In his article, “Watchdogs have failed us over energy prices” (Perspective, 22 September), he asserted that “renewable energy means higher prices for consumers” when in fact his own colleague, Energy Secretary Chris Huhne, has stated that supporting the renewables industry will, in the long run, protect us from future hikes in gas prices in the coming years. He also seems to overlook the


depositing of greenhouse gases underground rather than into the atmosphere was supposed to account for a fifth of the world’s emissions reductions under the agency’s roadmap for keeping global temperature rise within 2C (4F) by the end of the century.

NuGen

Scottish and Southern Energy is in talks to pull out of a consortium planning to build a nuclear power plant in the UK, as the company seeks to concentrate on renewable energy. The withdrawal of one of the UKs two big utilities, and its second-biggest electricity generator, from the new build programme would be a blow to the governments ambition to secure a new generation of reactors. NuGen is one of three consortiums looking to build nuclear reactors in the UK, with plans for two, or possibly three 1.6GWa rally from King Square to the Cornhill in Bridgwater on Saturday, October 1, from 1pm to 4pm. Then on October 3, the campaigners will form a blockade at the gates of Hinkley Point from 7am.

EDF Energys plans for the first of a new wave of nuclear reactors, Hinkley Point, has been dealt a blow after the High Court granted a judicial review into part of the project. According to the Times, a land-owner opposed to EDFs plans to build temporary accommodation for 1,000 workers on its land has been successful in securing the legal review. Innovia Cellophane, which owns the 50 hectare site adjacent to the Hinkley Point site where the accommodation is proposed, sought the review after talks to sell the land to EDF failed to


second molar furcation.](dpjo-19-03-0036-g03){#f03}

Evaluation of the buccal alveolar bone crest level of maxillary posterior teeth was conducted by means of orthoradially reformatted images perpendicular to the contour of the dental arch (cross sections), passing through the center of the buccal aspect of the deciduous canines, deciduous first molar and through the center, mesial and distal areas of the buccal aspect of deciduous second molars and permanent first molars. [Figure 4](#f04){ref-type="fig"} illustrates the linear variable obtained on each of these eight images both before and after expansion.

![Measurement of maxillary posterior teeth buccal alveolar crest level. BACL: buccal alveolar crest level measured from the buccal cusp tip to the buccal alveolar crest.](dpjo-19-03-0036-g04){#f04}

Statistical analyses
--------------------

All measurements were performed twice within a monthly interval by the same calibrated examiner. Statistical analysis was performed taking  0.851
  Permanent 1^st^ molar/center   21   7.68 ± 0.96     7.59 ± 1.10     -0.09    0.474    0.640
  Permanent 1^st^ molar/distal   19   7.91 ± 0.92     7.81 ± 0.84     -0.10    0.495    0.627

\*Statistically significant at P \< 0.05

DISCUSSION
==========

Spiral CT proves valuable in assessing alveolar bone thickness and level . Fuhrmann et al^[@r16]^ demonstrated that buccal and lingual bone plates can be identified in spiral CT images provided that they are at least 0.5 mm thick. On the other hand, when the periodontal ligament space is apparent, CT identifies even thinner buccal and lingual bone


mechanisms underlying observed phenotypes, for example molecular abundances or morphological modifications.

In this work, we will attempt to solve an inverse problem which arose in the study of a signalling pathway. Compared to pathways of metabolic reactions, which are of a limited size comprising up to a few hundreds of proteins, signalling processes involve about 20% of the genome, i.e. thousands of expressed proteins \[[@B10]\], most still unidentified and of unknown function. Protein signalling networks spread information throughout the cell and mediate a number of fundamental processes \[[@B11]-[@B14]\]. The growing availability of reliable genomic and proteomic data, made it possible to build up protein interaction maps (PIMs) of increasing complexity. New high-throughput experimental and in silico technologies allow us to monitor protein-protein and genetic interactions: DNA and protein microarraysand (2) biochemical processing, such as phosphorylation and phosphatization. On one hand, the few public sources of kinetic data on binding protein interaction often provide only dissociation constants, i.e. values describing an equilibrium state that offer only partial information about the dynamics of the reaction. To our knowledge, only the KDBI database \[[@B60],[@B61]\] was specifically created to store binding and dissociation rate constants. Other repositories, such as MINT \[[@B62],[@B63]\] and BIND \[[@B64],[@B65]\] offer few examples of dissociation constants. On the other hand, biochemical modifications occur in enzymatic reactions, therefore kinetic data can be found in databases entirely devoted to enzymes, first of all Brenda \[[@B66],[@B67]\] where kinetic constants are specified for several organic substrates, and partially the above cited KDBI.

A further source of signalling pathways and of p-p


course of a concentration, for example that of a phosphorilated protein. Radioimmunoassays are very sensitive methods but are even complex, expensive and dangerous to set up; protein arrays offer the advantage of a high throughput approach, while ELISA and immunoblotting are easier to implement and, thus, widely used, though they allow a lower threshold of detection when a very low concentrations of radioactive compounds is present \[[@B79]\]. The experimental error of quantitative immunoblotting can be significantly reduced by computational techniques of data analysis, error estimate and simulation: these allow to monitor activated signalling pathways in real time and to discriminate between different models.

Enzymatic reactions can be monitored, nowadays, in a high throughput scale both in vivo and in vitro: this allows us to measure kinetic parameters characterizing fundamentalalgorithm starts assigning every individual with random genome. The initial genes *g*~*i*~were randomly generated in the following manner: *g*~*i*~= 10^α^where *α*comes from a flat (white noise) distribution in the range *α ∈*\[-5, 0\]. This guarantees that the distribution of the initial parameters is flat in the logarithmic scale. The range is expanded in proportion to the number of components NC where the node (i) is a protein complex and if NC \> 2: the range becomes *α ∈*\[-5 \* (*NC*- 2), 0\].

The Fitness Function F() is here defined, for each individual, as the inverse of the squared Euclidean distance between the experimental time course of the concentration of the activated fraction of ERK-1, c-Raf, MEK, PKC-iota proteins (see above) and the simulated time course for the same species,


evolutionary strategy based on a thermalization-equivalent process of the system, in fact it is commonly used in computational physics to find minima of the energy states. At the heart of the method is an analogy with the slow cooling of liquids, a process called \"annealing\". A slow exploration of the energy landscape ensures that the absolute minimum is reached, if it is unique. From another point of view, the SA could also be consider a form of GA where a single individual evolves alone by means of random mutations, without any cross-over as no other individual is available. The SA and another problem-solving technique called the hill-climbing show some similarities to GAs: in both algorithms one single solution is evolving, instead of a population of candidate solutions. Theseparallel calculations on 8, 16 and 30 CPUs and are the average over different session, this explains the small discontinuities in the decreasing trend. The time required to reach the saturation decreases as the number of CPUs increases.](1471-2202-7-S1-S6-3){#F3}

![**Simulated and experimental data**. Comparison of experimental and simulated data. The experimental time courses of concentration for the proteins used as constraints in the calculation of the fitness function, is compared with the corresponding simulated behaviours.](1471-2202-7-S1-S6-4){#F4}

![**Proximity matrix of solutions**. Normalized frequency histogram of the elements of the proximity matrix built by computing the non-squared Euclidean distance \|\|log~10~*K*~*i*~, log~10~*K*~*j*~\|\|~*i*,\ *j*=\ 1\...*n*~, where {*K*~*i*~} and {*K*~*j*~} represent single solution parameter sets and n is the number of unknown model parameters. On the abscissa the distance values. For comparison we show also the distribution


of the proximity matrix for a large set of randomly generated K vectors.](1471-2202-7-S1-S6-5){#F5}

![**Distribution of the coefficients of variation of solution parameters.**The coefficient of variation *StdDev*(log~10~*K*~*i*~)*/Mean*(log~10~*K*~*i*~), where {K~*i*~}~*i*=\ 1\...*n*~is any kinetic parameter, was computed for every parameter across the entire ensemble of solution sets. Their distribution is shown (red line). For comparison the distribution of the coefficient of variation of a variable X is shown (green line), where X is sampled from a uniform distribution in the interval \[-5,0\]. The distribution of the coefficient of variation can be approximated by a Gaussian density function N(*μ, σ*) with *μ*= 2/![](1471-2202-7-S1-S6-i19.gif) and *σ*= 0.07 (in blue): the *μ*value is the coefficient of variation of the uniform distribution, while *σ*is the standard deviation of a random set of coefficients of variation obtainedOAKLAND — A key witness, a former inmate, testified that former Alameda County sheriff’s deputies accused of instigating the throwing of fecal matter in the county jail, would call them “crappuccinos” or “spreading the gospel.”

Former Alameda County Sheriff’s Deputies Justin Linn and Erik McDermott are charged with felony assault under the color of authority, witness intimidation and conspiracy to obstruct justice in connection with those attacks from 2016 and others that occurred at Santa Rita Jail in Dublin.

Judge Morris Jacobson is expected to determine next week if there’s enough evidence to try the two men.

An inmate, Shane Woodcook, who worked in the F-pod of Building 2 where the alleged crimes took place, testified during the hearing, laying out his firsthand knowledge of the allegations. Another inmate testified that


The similarities are inescapable. Born a generation apart, singers Abbey Lincoln and Dee Dee Bridgewater grew up in Michigan, won acclaim for their acting, were married to musicians, revived their careers with the help of a French record producer and have long worn the robes of jazz royalty. -Finger localization and the prediction of reading disability.
Tests of finger localization, letter naming, design copying, and receptive vocabulary were given to 100 kindergarten children. When the children had reached the end of first grade, their achievement in reading and arithmetic was related to these test performances. Poor readers had scores lower than good readers on all kindergarten measures, with their finger localization and letter naming performances being particularly poor. Finger localization scores correlated significantly with both reading and arithmetic achievement. These findings are interpreted as suggesting that the significance of finger localization as a predictor of reading and arithmetic achievement results from the ability of finger localization performance to reflect not simply one specific skill, but rather a number of important cognitive abilities.


Machine learning and statistical methods for clustering single-cell RNA-sequencing data.
Single-cell RNAsequencing (scRNA-seq) technologies have enabled the large-scale whole-transcriptome profiling of each individual single cell in a cell population. A core analysis of the scRNA-seq transcriptome profiles is to cluster the single cells to reveal cell subtypes and infer cell lineages based on the relations among the cells. This article reviews the machine learning and statistical methods for clustering scRNA-seq transcriptomes developed in the past few years. The review focuses on how conventional clustering techniques such as hierarchical clustering, graph-based clustering, mixture models, $k$-means, ensemble learning, neural networks and density-based clustering are modified or customized to tackle the unique challenges in scRNA-seq data analysis, such as the dropout of low-expression genes, low and uneven read coverage of transcripts, highlystrengths of the university and its partners and that considers the translation of research findings to practice. This multidisciplinary research training will foster among trainees from diverse disciplines a culture of collaboration and partnership when confronting Global Health problems. PUBLIC HEALTH RELEVANCE: Multidisciplinary teams that collaborate and work together are essential to address effectively global health challenges.


Family history influences the tumor characteristics and prognosis of breast cancers developing during postmenopausal hormone therapy.
Long term use of postmenopausal hormone therapy (HT) has been reported to increase breast cancer risk. On the other hand, observational studies suggest that breast cancers diagnosed during HT may have a more favorable prognosis. While family history is a risk factor for breast cancer, and genetic factors also influence prognosis, the role of family history in combination with HT use has been little studied. We investigated the relationship between HT, family history, and prognosis in 584 (267 exposed) familial and 952 (460 exposed) non-familial breast cancer cases, using three survival end points: death from breast cancer (BCS), distant disease free survival (DDFS), and local recurrence free survival (LRFS). Among non-familial cases, HTor two-way ANOVAs for repeated measures with the rat line as a between-subjects factor and the time (i.e., copulatory test or dialysate fraction depending on the data set) as a within-subjects factor. When ANOVAs revealed statistically significant main effects and/or interactions, pairwise comparisons were performed by using the Tukey's multi comparison test or Bonferroni's corrected multiple t-tests.

![Percentage of male WT, HET and DAT KO rats (8--10 per group) engaged in sexual behavior in copulatory tests 1--5. During each test, male rats were put together with a sexually receptive female rat for 60 min as described in the "Materials and Methods" section. The percent of rats showing mounts, intromissions and that reached ejaculation is reported (Chi-square test, not significant).](fnbeh-14-00058-g0002){#F2}

![Sexual behavior of male WT, HET and DAT KO rats in


the first series of the copulatory test 1, 2, 3, 4 and 5. Male rats were put together with a sexually receptive female rat and observed in order to measure copulatory parameters as described in the "Materials and Methods" section. Copulatory parameters were measured directly or calculated as described in the "Material andMethods" section. Values are means ± SEM of 8/10 rats per group. \**P* \< 0.05, \*\**P* \< 0.01, \*\*\**P* \< 0.001, \*\*\*\**P* \< 0.0001 with respect to WT; ^\#^*P* \< 0.05, ^\#\#^*P* \< 0.01, ^\#\#\#^*P* \< 0.001, ^\#\#\#\#^*P* \< 0.0001, DAT KO with respect to HET; ^§^*P* \< 0.05, ^§§^*P* \< 0.01, ^§§§§^*P* \< 0.0001, with respect to T1 (two-way ANOVA for repeated measures followed by Tukey's or Bonferroni's pairwise comparisons).](fnbeh-14-00058-g0003){#F3}

![**(A)** Extracellular dopamine and **(B)** glutamicthose showing the higher basal levels of extracellular dopamine, or the lowest dopamine release during sexual activity, in the Acb shell is unknown. No help in this circumstance is provided by our previous findings on the expression of BDNF and trkB in RHA and RLA rats (Sanna et al., [@B89]). Indeed similar levels of BDNF were found in the mPFC, VTA and Acb, shell and core, of RHA and RLA rats after five copulatory tests, even though RHA rats have a higher dopaminergic tone in the mPFC and the Acb shell than RLA rats. Likewise, no significant differences were detected in trkB levels between RHA and RLA rats in the above brain areas except for the mPFC, in which higher levels of trkB levels were found in RLA


CeSASt, University of Cagliari, for animal housing and care and the Italian Institute of Technology (IIT) for the kind gift of DAT KO, HET and WT rats used in this study.

**Funding.** This work was partially supported by a grant from the Italian Ministry of the University and Research (MIUR) to FS (Scientific Independence of young Researchers_2014, Project Code No. RBSI14IUX7) and by grants from the University of Cagliari to AA, MM, FS, MS, and MQ (FIR 2016-2017-2018). RG was supported by the project ID: 51143531 of the St. Petersburg State University, St. Petersburg, Russia.

^1^<https://www.licor.com/bio/image-studio-lite/download>

[^1]: Edited by: Raúl G. Paredes, National Autonomous University of Mexico, Mexico

[^2]: Reviewed by: Anders Agmo, Arctic University of Norway, Norway; Wendy Portillo, National Autonomous University of Mexico, Mexico

[^3]: **Specialty section:** This article was submitted(1) Field of the Invention
The present invention relates to torpedo launching systems, and, more particularly, to hydraulic or other pressurized fluid systems for operating the various elements of a torpedo tube assembly.
(2) Description of the Prior Art
As is well known, modern submarines generally employ torpedo tube assemblies which have a number of operational components which must be moved between positions in which the torpedo may be loaded into the tube and positions in which the torpedo may be fired from the tube. Among such components are the breech door, and muzzle door, and a shutter which fairs the submarine's outer hull. Stop bolts are employed to position and control motion of the torpedo within the torpedo tube, and valves allowing flow of water into the torpedo tube, equalization


into an alternate (alternating (AC)) voltage to the transformer 104, so that the transformer 104 accordingly generates the alternate voltage level capable of driving the lamp 106.
Along with the increase in the size of the liquid crystal display, the large-sized liquid crystal TV for instance, the backlight module has to provide a higher luminance so as to maintain the display quality. In order to improve the luminance of the backlight module, not only the size of the lamp needs to be enlarged, but also the number of the lamp used needs to be increased.
In order to reduce the cost of driving a number of lamps, a conventional practice is to drive a number of lamps by a set of drive circuits 100. Referring to FIG. 2, a diagramBand no. 1 on the occasion of the presentation of a suite of colors to the Battalion of State Fencibles"—Cover. "Composed and respectfully dedicated to Col. James Page"—Cover. Description: 1 score (5 pages).
 Chew, William W. State Fencibles: A Few Points on Guard Duty. 1887. Description: 22 pages; 14 cm.
 J. J. [Colonel James Page: State Fencibles Philada.] : [Pencilled in Below Portrait]. [Place of publication not identified]: J.J. [on stone], 1839. Description: 1 print: lithograph ; 22.8 x 18.6 cm.
 Johnson, Francis, and Daniel Nightingale. The State Fencibles: Captain Page : Kent bugle quick step. [United States]: D. Nightingale, 1988. Notes: Originally for band. Description: 1 score (14 pages); 37 cm. Notes: For voice and piano. Subsequent verses printed as text on p. [3]. At head of title, monochrome lithograph


An advertisement from 1905 reads:

"The game that quickens the eye, steadies the hand, and sets the whole body tingling with a delightful exhilaration, depends on the ball."

The pages inside will expand upon that 'delightful exhilaration' by paying homage to the decades of old tennis balls that were so essential to the sport we love so much today. There is nothing like an old tennis can, box or ball to give you a taste of tennis from a bygone era. That's why they are so collectible.

So... whether you are collecting tennis balls, searching for info on antique tennis, or are simply looking for a bit of nostalgia, you've come to the right place. Vintage Tennis Balls is looking to be THE place on the Web for information about antiquefor the 1983-84 school year. Prior to the start of his second year, and while her appeal was pending, the appellant attempted to enroll Tad in a public school. The appellee moved the trial court to again hear the parties and determine where the child should attend school. He also moved the court to issue a rule requiring the appellant to show cause why she should not be held in contempt and *299 for a restraining order. In turn the appellant filed her petition for a writ of prohibition and for intermediate relief. On August 22, 1984, this court temporarily enjoined the Kenton Circuit Court from taking further action in the matter until a decision on the merits of the petition could be addressed by a panel of


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</Project>detriment on any such representations. Plaintiff has not apparently attempted to sell his car in the used car market and simply asserts the bald conclusion that its value in that market has decreased.
Plaintiff simply does not allege the requisite elements of fraud, let alone with the particularity required of Fed.R.Civ.P. 9(b). Plaintiff's First Amended Complaint was found to be "insufficient to permit the inference of mail fraud and satisfy the particularity requirement of Fed.R.Civ.P. 9(b)." Opinion at 5. The second count of his Second Amended likewise fails to plead common law fraud with sufficient particularity.
The court will thus grant defendant GM's motion and dismiss both counts with prejudice.

AMENDED ORDER
This matter having been brought before the court on defendant's motion to dismiss plaintiff's second amended complaint and plaintiff's motion


344 F.2d 950
FLAGLER HOSPITAL, INC., and Claude L. Weeks, Appellants,v.Robert B. HAYLING et al., Appellees.
No. 21968.
United States Court of Appeals Fifth Circuit.
May 6, 1965.

Chester Bedell, C. Harris Dittmar, Robert P. Smith, Jr., Jacksonville, Fla., Bedell, Bedell, Dittmar & Smith, Jacksonville, Fla., of counsel, for appellants.
Michael Meltsner, Jack Greenberg, Constance Baker Motley, Leroy D. Clark, New York City, Earl M. Johnson, Jacksonville, Fla., for appellees.
Before TUTTLE, Chief Judge, and RIVES and BELL, Circuit Judges.
PER CURIAM.

1
This appeal is from an order for permanent injunction which we construe as follows:

2
(1) That it does not enjoin the defendants from denying the plaintiffs and the class they represent admission to the Defendant Hospital generally, for the answer shows that 'Flagler Hospital does not now and never has pursued a policy of denying admissionarrange the etched shape.
The temperature control for the object to be processed is generally carried out by a cooling mechanism provided on the supporting table. The cooling mechanism adopts a construction for feeding a refrigerant into a refrigerant circulating passage extending in the supporting table and for absorbing heat by the refrigerant to cool the object to be processed. The refrigerant in a refrigerant tank temperature-controlled by a cooling circuit is fed into the refrigerant circulating passage by a pump, and the refrigerant returned from the refrigerant circulating passage is temperature-controlled by the cooling circuit to be fed into the refrigerant tank. The temperature of the refrigerant in the refrigerant tank or the refrigerant fed from the tank into the refrigerant circulating passage is monitored to carry out