[Monks vocalizing]
[Monk explains meaning of Mandala]
[English Translation]: So out of those many types of Mandala all of them are equally kind of powerful enough
to open up yourself to evict yourself to the
instinct powers the true natures of us which
is you know the enlightened natures.
But the sand mandala believes to be one of
the best art, visual art you receive the blessings
of the the Mandala.
The sands that we use for the creations of
the mandala it comes from earth it's what
we call a marble.
Its grinded marble grinded sands and before
we take it from the earth we need to do some
rituals asking the permissions from the nature.
The blessing of the nature and invocations
of nature spirit and some kind of promising
and many things have to happen from the very
beginning point, and then weto the soul without going through the brain.”

In conjunction with “The Collecting Impulse” exhibition, Mary Lee Corlett of the National Gallery of Art will speak at The Blanton about the Vogel collection on June 21, and the museum will screen the award-winning documentary “Herb & Dorothy” at the museum on July 19.

Claire Howard is The Blanton’s curatorial administrative assistant. She recently received her master’s in art history from the University of Texas at Austin. This story originally appeared in the e-magazine Aether and on The Blanton Blog.


1920s unlike any player has ever dominated any league, but by general acclaim, they were weak opponents upon whom he trod.Aaron had to deal directly with scrutiny based on the color of his skin, playing (as he did) shortly after baseball became an integrated game. Hornsby never had to face an African-American pitcher, but also never got to play regular night games.
Comparisons across eras in baseball call into question variables utterly impossible to quantify. Lining up the best hitters of all-time is an exercise in vapid punditry, and no one needs it.
It is possible, though, to figure out who were the best batters on individual eras, to find the proper order in which to place (say) Barry Bonds, Frank Thomas, Jeff Bagwell, Edgar Martinez and John Olerud, becausebecome. Pitchers simply feared him too much to throw many strikes.

A Few Words: Injuries and a second tour of military duty slowly zapped Williams of his gift, and made it hard for him to stay on the field at times. He still walked three times as often as he struck out, though, and still got on base roughly 48 percent of the time. His elevation over the heads of other hitters was dizzying. He earned three MVP awards in the 1950s, but received none. He also earned five in the 1940s, winning just twice. Hell hath no fury like a sportswriter disdained.

The 1960s: Power Up

Whereas all previous great hitters had been tremendous batters for average and/or on-base skills, the 1960s (in a fairly appropriate nod to the more


obtained from short circuit characteristics. This is denoted as FAR.

Under short circuit condition as resistance and leakage reactance of armature do not play any significant role, the armature reaction reactance is dominating and hence the power factor of such purely reactive circuit is zero lagging. Hence FAR gives demagnitising ampere turns. Thus the field m.m.f. is entirely used to overcome the armature reaction which is wholly demagntising in nature.

The two components of total field m.m.f. which are FO and FAR are indicated in O.C.C. (open circuit characteristics) and S.C.C. (short circuit characteristics) as shown in the Fig. 1.

Fig. 1

If the alternator is supplying full load, then total field m.m.f. is the vector sum of its two components FO and FAR. This depends on the power factor of the             }
            }
        }
        ]]>
    </property>
    <property name="testSearch">
        <![CDATA[
        {
            "query": {
                "match" : {
                    ## use a variable named description defined in condition.


record 554 yards of total offense and tied the school record when he threw six touchdown passes vs. West Virginia…set a school record with 71 pass attempts vs. Oklahoma State. 2011: The Manning Award finalist ended his junior season as the owner of 13 program passing records, including becoming Oklahoma’s all-time passer with a then 12,379 career yards, which had ranked fifth in Big 12 Conference history…the All-Big 12 first-team pick by The NFL Draft Report guided a team that finished fifth in the nation in passing and total offense, and finished 10th in scoring…was the nation’s sixth-rated player with an average of 341.46 yards per game in total offense…ranked third on the team’s annual list with 4,463 yards passing and eighth with 29 touchdown passes…scored two rushingпоиска указываются в функции where (так же можете посмотреть решение andWhere для множественной выборки).
В итоге у вас должно получиться что-то вроде
$options->$options::find()->where(['section' => 'access'])-orderBy('prior')->asArray->all();
Советую почаще обращаться сюда. Это реально сэкономит кучу времени.


A very large cache (EDRAM or embedded DRAM (dynamic random access memory)) can be implemented as a sector cache to reduce the size of a tag used to access cache lines. With a sector size of 1K-byte block (known as a ‘superline’) that contains 16 consecutive 64-byte cache lines, the tag size can be reduced by a factor of 16 compared to a non-sectored design. Line state of each cache line also needs to be in the tag. Thus, to further reduce storage size in the tag array, instead of having a line state error correction code(s) (ECC) generated for each individual cache line, all cache line states in a superline can be combined into a 32-bit line state vector with one ECC, thereby reducing total ECC bitsfees.

Citizens president and chief executive officer Barry Gilway told the company's board of directors at its meeting on Friday that the company is undergoing an internal study to get a handle on its litigation costs.

He said that 87 percent of all new litigation since January has come from Miami-Dade, Broward and Palm Beach counties and that 56 percent of those claims allege water losses. Many water losses are denied, he said, because Citizens only covers sudden and accidental water damage, not long-term leakage.

"The comprehensive review that we are doing is how do we get our arms around the significant increase in water damage losses," he said.

Citizens spokesman Michael Peltier said part of the surge in lawsuits since 2010 results from disputes over sinkhole claims.

"We have found that the


    if (!$source->smarty->allow_php_templates) {
            throw new SmartyException("PHP templates are disabled");
        }
        if (!$source->exists) {
            if ($_template->parent instanceof Smarty_Internal_Template) {
                $parent_resource = " in '{$_template->parent->template_resource}'";
            } else {
                $parent_resource = '';
            }
      initial reaction to discovering it in my final game would be to ban it so it wouldn't show up again and then blow it to pieces for the sheer satisfaction of it," Moffit said. "Go ahead, create a walking phallus. See how long it lasts in the databases and galaxies of Spore."

Well, it looks like video games and the inter-web are safe once more.

In a related story, I just spent, like, 45 minutes stomping the corpse of a hooker after killing her AFTER fucking her. GTA rules.


(Dave Willis) kidnaps Pam.

“Honeypot” (Season 1)“Archer Vice: A Kiss While Dying” (Season 5)

The comedian and star of CBS’s “The Odd Couple” played a flamboyant gay hitman who twice crosses paths with Archer, yet manages to escape every time.

“Honeypot” (Season 1)“Archer Vice: A Kiss While Dying” (Season 5)

Perlman (“Sons of Anarchy”) made two appearances as a gay Cuban spy whom Archer tries to seduce in order to retrieve a disc for his mother. Later he helps Archer and Mallory try to start their secret drug cartel.

“Bloody Ferlin” (Season 3)

The “30 Rock” alumnus starred as the white trash, drug dealing brother of Ray (Adam Reed), who must come to his brother’s rescue when he is threatened by the local sherriff.

“The Man from Jupiter” (Season 3)

Archer meets his childhood hero, butemployed as a police officer with the Hugo Police Department; that in the early morning hours he observed a green Chevrolet veering across both lanes of traffic. He turned on the red lights and stopped the vehicle. He testified that when the defendant stepped out of the vehicle he was staggering and had to lean against the car for support. Defendant's speech was "thick and he had trouble focusing his eyes, he had a strong odor of alcoholic beverage ." [Tr. 6]. It was his opinion that the defendant was intoxicated, and he surrendered the defendant to Officer Cline.
Deputy Sheriff Leroy Cline testified that on November 2, 1975, he transported the defendant to the County Jail; that either he or Woodrow Bowden was with the defendant until the


his first assignment of error, defendant asserts that the trial court erred in *1308 not giving his requested instruction of the lesser included offense of Driving While Impaired. We are of the opinion that the instant case is distinguishable from the recent case of Jackson v. State, Okl.Cr., 554 P.2d 39 (1976). In Jackson, supra, defendant did not dispute he had been drinking an alcoholic beverage, but rather raised as a defense that "the alcohol he consumed had merely impaired his ability to drive, not intoxicated him." We thus concluded that this testimony was sufficient to overcome the presumption raised by the blood test results that defendant was intoxicated giving rise to an issue of fact for the jury. In the instant case neither defendant nor the StateLateLine

LateLine - Season 2 Episodes

“Pearce on Conan”

Pearce does a skit for the Conan O'Brien show, which leads to more skits with Conan's sidekick, Andy Richter. Meanwhile, Raji is afraid that won't get his bonus.

Episode 2

“Protecting the Source”

Al may have to go to prison, unless he reveals the source of a story.

Episode 3

“The Minister of Television”

Raji promisses to bring his African friend as a guest on the show but, when his friend doesn't come, Raji gets fired. The new intern is a girl who has a crush on Al. When the two kiss, Al remembers he is married...

Episode 4

“Kids 'N' Guns”

Trying to blow the cover of an illegal gun salesman, Al and Raji go undercover by trying to buy guns. Meanwhile, Vic's daughter lets slip that her father has


-- Created on: 1994-10-07
-- Created by: Bruno DUMORTIER
-- Copyright (c) 1994-1999 Matra Datavision
-- Copyright (c) 1999-2014 OPEN CASCADE SAS
--
-- This file is part of Open CASCADE Technology software library.
--
-- This library is free software; you can redistribute it and/or modify it under
-- the terms of the GNU Lesser General Public License version 2.1 as published
-- by the Free Software Foundation, with special exception defined in the file
-- OCCT_LGPL_EXCEPTION.txt. Consult the file LICENSE_LGPL_21.txt included in OCCT
-- distribution for complete text of the license and disclaimer of any warranty.
--
-- Alternatively, this file may be used under the terms of Open CASCADE
-- commercial license or contractual agreement.

class ComputeApproxOnPolarSurface from ProjLib
	---Purpose: Approximate the  projection  of a  3d curve  on an
	--       The rough, dark suede lace-up boots feature zippers on the instep and double buckles at the top. Thus far it seems like these were created solely for the show, but stay tuned for further developments if any type of release comes to light.


three major groups on the basis of the possible scenarios of their core structures (shown in [Figure 3](#molecules-24-03278-f003){ref-type="fig"}): (I) polymethoxyflavone-structure-based metabolites, the DPI at *m*/*z* 151 + X (X = molecular weight of substituent groups, such as 14, 16, 30, for CH~2~, O, OCH~2~, etc)., yielded by RDA rearrangement occurred on positions 0, 4-position of C-ring; (II) polymethoxyflavanone-structure-based metabolites, the DPI at *m*/*z* 211 yielded by RDA rearrangement occurred on positions 1, 3-position of C-ring with methyl group transfer from B ring to A ring making carbon ions more stable form; and (III) polymethoxychalcone-structure-based metabolites, the DPI at *m*/*z* 221 yielded by the RDA rearrangement occurred on positions 1, 3-position of C-ring, and another DPI at *m*/*z* 197 yielded by RDA rearrangement occurred on positions 1, 4-position ofpositions of the hydroxy group and methoxy group should vary slightly. Additionally, the methodology of DMC is a more logical and hierarchical identification technique, which could guide metabolite screening, enrich metabolic theories, and reveal metabolic processes reasonably.

Cluster centers of the HTF DMC were perceived as the main essential ingredients in the metabolism study such as mono-hydroxy-tetra-methoxyflavanone, mono-hydroxy-tetra-methoxychalcone, mono-hydroxy-penta-methoxyflavone, and so on. With the prolongation of metabolic reactions, implying the generation of metabolite clusters, metabolite clusters have been increasingly developed and related, and are not completely independent. Conversely, they have links, influence, and even intersection among each other as well as a radial metabolism net, which confirmed the hypotheses of DMC put forth in this thesis.

When Archimedes said, "Give me a place to stand and I will move the


Earth," he was referring to leverage. Here, we said "Give me a prototype drug to metabolize, and I will unlock its DMC". Unlike previous studies, DMC provides a metabolite-led net where drug metabolites can be detected, analyzed, and identified rapidly and accurately. Specifically, it is available to simultaneously enable the qualitative analysis of multiple metabolites to be performed on the prototype drug and metabolism cluster centers with different metabolism pathways in the same analysis. In addition, it is a potentially powerful methodology to significantly enhance comprehensive metabolite profiling and provide an opportunity to alter the process of metabolite identification dramatically. Last but not least, DMC enables the discovery of drug metabolites, the characterization of biosynthetic pathways, the understanding of the chemistry of ecological interactions, and the development oflight/dark cycle) with free food intake and water consumption. After one week of acclimatization, rats were randomly divided into two groups: the drug group (*n* = 4) and the control group (*n* = 4). Rats in the drug group were given a dose of 250 mg HTF, which was suspended in 0.5% carboxymethyl cellulose sodium (CMC--Na) solution per kilogram of body weight, by oral gavage at. Equivalent volumes of the 0.5% CMC--Na aqueous solution was administrated to rats in the control group. The animal protocols were approved by the institutional Animal Care and Use Committee at the Beijing University of Chinese Medicine. The animal facilities and protocols complied with the Guide for the Care and Use of Laboratory Animals (USA National Research Council, 1996).

4.3. Sample Collection and Preparation


of unknown metabolites, which indicates that the proposed methodology is reliable for use to discover and identify drug-related constituents.

**Sample Availability:** Samples of the compounds are not available from the authors.

The following are available online.

######

Click here for additional data file.

J.Z. conceived and designed the experiments; L.D. supervised the experimental plan; X.M. and Z.L. performed the experiments; Y.W. and J.L. analyzed the data; Y.W. wrote the paper; J.Z. and L.D. reviewed the manuscript; all authors read and approved the final manuscript.

This work was financially supported by the Beijing Nova Program (Z171100001117029), the Open Project Program of Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica (No. JKLPSE201816), and the Beijing University of Chinese Medicine Fund for Distinguished Young Scholars (No. 2018-JYB-XJ008).

The authors declare no conflicts of                                       MS2\[329\]:171(100),229(56),293(54),311(49),211(40),                              Loss of 2CH~2~

  MS3\[171\]:127(100),153(74),125(37)


                                    MS2\[343\]:328(100),313(5),315(1)                                                 Loss of CH~2~

  MS3\[328\]:313(100),312(15),282(14),309(10),299(7),300(2),151(1)                                                                       MS2\[377\]:197(100),207(82),359(33),175(21),221(14)                               Oxidation + Chalcone Formation

  MS3\[197\]:182(100),164(21),165(5),137(3)


                        MS2\[389\]:374(100),359(26),208(3),373(2),280(1)                                  Loss of Carbonyl + Di-Methoxylation

  MS3\[374\]:359(100),208(4),165(3),180(3),193(1)                                                                            0.1                                                                       MS2\[389\]:179(100),164(33),374(21),149(14),359(2),121(2),205(2)                  Loss of Carbonyl + Di-Methoxylation

  MS3\[179\]:164(100),149(2)


or access app functionality that is available for authenticated users.

private void performLogin(String email, String password) { firebaseAuth.signInWithEmailAndPassword(email, password) .addOnCompleteListener(this, new OnCompleteListener<AuthResult>() { @Override public void onComplete(@NonNull Task<AuthResult> task) { if (task.isSuccessful()) { Log.d(TAG, "login success"); } else { Log.e(TAG, "Login fail", task.getException()); Toast.makeText(EmailPasswordAuthActivity.this, "Authentication failed.", Toast.LENGTH_SHORT).show(); } //hide progress dialog hideProgressDialog(); //enable and disable login, logout buttons depending on signin status showAppropriateOptions(); } }); }

You can provide update password functionality to authenticated user. To update password in Firebase, you need to call updatePassword method on FirebaseAuth object passing new password as shown below.

private void updatePassword() { final FirebaseUser user = firebaseAuth.getCurrentUser(); final String newPwd = ((EditText) findViewById(R.id.update_password_t)).getText().toString(); if(!validateResetPassword(newPwd)){ Toast.makeText(EmailPasswordAuthActivity.this, "Invalid password, please enter valid password", Toast.LENGTH_SHORT).show(); return; } user.updatePassword(newPwd) .addOnCompleteListener(new OnCompleteListener<Void>() { @Override public void onComplete(@NonNull Task<Void> task){ if (task.isSuccessful()) { Toast.makeText(EmailPasswordAuthActivity.this, "Password has been updated", Toast.LENGTH_SHORT).show(); } else { Log.e(TAG, "Error in updating passowrd", task.getException()); Toast.makeText(EmailPasswordAuthActivity.this, "Failed to update passwrod.", Toast.LENGTH_SHORT).show(); } } }); }

Firebase Authentication Verify Email

To verify email address used for creating email-password authentication account, an email with a link can be sent to user by calling sendEmailVerification method on FirebaseAuth object.

Firebase Authentication Reset Password

To provide reset password option for non authenticated users, you can prompt user to enter email and call sendPasswordResetEmail on FirebaseAuth object to send an email containing link that allows user to reset password. Authentication email templates can be customized in firebase console.

private void sendResetPasswordEmail() { final String email = ((EditText) findViewById(R.id.reset_password_email)) .getText().toString(); firebaseAuth.sendPasswordResetEmail(email) .addOnCompleteListener(this, new OnCompleteListener<Void>() { @Override public void onComplete(@NonNull Task<Void> task) { if (task.isSuccessful()) {


private EditText passwordET; private FirebaseAuth firebaseAuth; @VisibleForTesting public ProgressDialog progressDialog; @Override protected void onCreate(Bundle savedInstanceState) { super.onCreate(savedInstanceState); setContentView(R.layout.email_pass_auth_layout); Toolbar tb = findViewById(R.id.toolbar); setSupportActionBar(tb); tb.setSubtitle("Authentication"); emailET = findViewById(R.id.email); passwordET = findViewById(R.id.password); firebaseAuth = FirebaseAuth.getInstance(); setButtonListeners(); } private void setButtonListeners(){ //login button findViewById(R.id.login_b).setOnClickListener(new View.OnClickListener() { @Override public void onClick(View view) { handleRegistrationLogin(); } }); //reset password - for unauthenticated user findViewById(R.id.rest_password_b).setOnClickListener(new View.OnClickListener() { @Override public void onClick(View view) { sendResetPasswordEmail(); } }); //logout button findViewById(R.id.logout_b).setOnClickListener(new View.OnClickListener() { @Override public void onClick(View view) { logOut(); } }); //Verify email button findViewById(R.id.verify_b).setOnClickListener(new View.OnClickListener() { @Override public void onClick(View view) { sendEmailVerificationMsg(); } }); //update password - for signed in user findViewById(R.id.update_password_b).setOnClickListener(new View.OnClickListener() { @Override public void onClick(View view) { updatePassword(); } }); //Order functionality to show how to secure firestore data //using; REQUIRES: loadable_module
; RUN: echo "import sys" > %t.py
; RUN: echo "print('args = ' + str(sys.argv))" >> %t.py
; RUN: echo "exit(1)" >> %t.py
; RUN: not bugpoint -load %llvmshlibdir/BugpointPasses%shlibext %s -output-prefix %t -bugpoint-crashcalls -opt-command="%python" -opt-args %t.py | FileCheck %s
; RUN: not --crash opt -load %llvmshlibdir/BugpointPasses%shlibext %s -bugpoint-crashcalls -disable-symbolication 2>&1 | FileCheck --check-prefix=CRASH %s
; RUN: not bugpoint -load %llvmshlibdir/BugpointPasses%shlibext %s -output-prefix %t -bugpoint-crashcalls -opt-command=%t.non.existent.opt.binary -opt-args %t.py 2>&1 | FileCheck %s --check-prefix=BAD-OPT

; Test that bugpoint disables symbolication on the opt tool to reduce runtime overhead when opt crashes
; CHECK: args = {{.*}}'-disable-symbolication'

; Test that opt, when it crashes & is passed -disable-symbolication, doesn't symbolicate.
; In theory this test should maybe be in test/tools/opt or
; test/Transforms, but since there doesn't seem to be another convenient way to
; crash opt, apart from the


for (auto path : dirs_to_remove_)
    RmDir(path);
}

std::unique_ptr<CpuFreqInfo> CpuFreqInfoForTesting::GetInstance() {
  return std::unique_ptr<CpuFreqInfo>(new CpuFreqInfo(fake_cpu_dir_.path()));
}

void CpuFreqInfoForTesting::AddDir(std::string path) {
  dirs_to_remove_.push_back(path);
  mkdir(AbsolutePath(path).c_str(), 0755);
}

void CpuFreqInfoForTesting::AddFile(std::string path, std::string content) {
  files_to_remove_.push_back(path);
  base::ScopedFile fd(
      base::OpenFile(AbsolutePath(path), O_WRONLY | O_CREAT | O_TRUNC, 0600));
  PERFETTO_CHECK(base::WriteAll(fd.get(), content.c_str(), content.size()) ==
                 static_cast<ssize_t>(content.size()));
}

void CpuFreqInfoForTesting::RmDir(std::string path) {
  PERFETTO_CHECK(rmdir(AbsolutePath(path).c_str()) == 0);
}

void CpuFreqInfoForTesting::RmFile(std::string path) {
  PERFETTO_CHECK(remove(AbsolutePath(path).c_str()) == 0);
}

std::string CpuFreqInfoForTesting::AbsolutePath(std::string path) {
  return fake_cpu_dir_.path() + "/" + path;
}

}  // namespace perfetto
A seat has a seat base or cushion, and often a seat back. The seat back allows a user to lean back, and the seat back supports the user's back as the user leans back. The seat back therefore needs rigidity to resist the force of the user leaning back. It is often desirable for the seat back to have cushioning in order to provide comfort to the user.
When producing a seat back, a back frame of rigid materials is often provided to provide the support for the user. When choosing a frame, strength is a significant consideration. The materials of the frame must be chosen and arranged so that the seat back can properly support the user. Cost is often a significant consideration, both in the cost


Bharatiya Janata Party’s core issues for a long time. The BJP had promised to implement a Uniform Civil Code in its election manifesto (“Sankalp Patra”) for the 2019 Lok Sabha elections. The Ram Janmabhumi title case is being heard by the Supreme Court on a daily basis.

A PIL filed in the Delhi High Court on UCC is being heard at present. A representative of the Law Commission informed the High Court that the issue of UCC will be placed before the 22nd Law Commission. The Court has listed the matter for further hearing on 27 August.

The court had earlier issued a notice to the Ministry of Home Affairs and the Law Commission of India, seeking their stand on a petition filed by BJP leader Ashwini Kumar Upadhyay, whoAs the population in the United States continues to increase, especially among the aging, the ability for traditional healthcare providers, such as hospitals and doctors' offices, to effectively provide treatment becomes increasingly challenging. In addition, as the average age of the population continues to increase, the number of people requiring care for long-term illnesses, such heart disease, diabetes and the like also increases.
Accordingly, alternatives to traditional health providers are being developed to accommodate these greater healthcare needs. Also, more effective and efficient systems are being developed to attempt to reduce the number of medical personnel necessary to treat or monitor patients. Specifically, systems are being developed that enable patients to have their conditions monitored at home, such as by themselves or a visiting nurse, and to provide data


separately from one another.
U.S. Pat. No.6,192,891, to Gravel et al., which is expressly incorporated herein by reference in its entirety, discloses an integrated portable diagnostic and medication delivery system. The system includes a housing and a monitor disposed in the housing for monitoring a characteristic of a bodily fluid sample obtained from an individual. A medication delivery pen and a lancet are each removably mounted to the housing. The monitor, which may be integrated into the housing, may monitor blood glucose levels, for example, and the pen may be employed for the delivery of insulin.
While the above described systems facilitate the self-administration and monitoring of medication, there is a need for additional features and improvements for such systems. None of the known systems provide feedback to the patientstarting from simple assumptions on the intrinsic properties of the quasar population as a whole – namely an optical quasar luminosity function and a prescription to associate a radio power to each object - and, through Monte Carlo simulations, generate unbiased quasar samples (Cirasuolo et al. 2003b). By applying observational limits in redshift, apparent magnitude and radio flux we can then compare the results of the simulations with the properties of observed samples. The aim of this approach is of course twofold: constrain the initial hypothesis on the intrinsic nature of quasars, by requiring properties of the simulated samples – such as $R^*_{1.4}$ and radio power distributions, fraction of radio detections etc. – to be in agreement with the observed ones; test the effects of the observational biases


we note no lack or deficit of sources between the RL and RQ regimes: the distribution has a peak at $R^*_{1.4} \sim 0.3$ and decreases monotonically beyond that value with only a small fraction ($\simlt 5$ per cent) of objects found in the RL regime which represent the long flat tail of the total distribution. This result contrasts the classical view of a RL/RQ dichotomy where a gap separates the two populations. Nevertheless we can still talk about a “dichotomy” in the sense that the data are compatible with an asymmetric distribution, with a steep transition region and only a small fraction of sources having high values of $R^*_{1.4}$. This result is in agreement, within the errors, with the findings from the new analysis of the SDSS presented byThe London Golf Club

This is undoubtedly one of the finest downland courses in Europe. Fast, undulating fairways allow you to chase the ball into position. The course is punctuated with exciting risk and reward tee shots over water that really get the heart pumping.

The International recently played host to Regional Open Qualifying and also tested a field of budding hopefuls as the venue for Stage 1 of European Tour Qualifying School in September.


Devastating fruit fly find in Miami-Dade

by Chip Carter | November 21, 2010

Florida authorities announced Nov. 15 that a peach fruit fly — Bactrocera
zonata — was found earlier this month during routine surveillance activities in
Miami-Dade County. It is the first time the species has been found in the
state.

The peach fruit fly is considered particularly devastating because it attacks
and compromises a wide variety of fruits, vegetables and nuts, such as
mangos, guavas, citrus, eggplants, tomatoes, apples, peaches, melons,
loquats, almonds and figs. Flies lay eggs in the fruits and vegetables; in a few
days, those eggs hatch, and maggots render the fruits or vegetables inedible.

"This is a disturbing find because of the extreme risks associated with exotic
fruit fly infestations," Charles Bronson, Florida commissioner of the Florida
Department of Agriculture & Consumer Services, said inprocess, involving an attempt at correct positioning followed by an X-ray to confirm the actual position of the end of the line. At that stage, if the line is found to extend beyond its target position, it can be pulled back. On the other hand, if the line falls short of the target, the risk of introducing infection means that the line is never inserted any deeper. Instead, the original line is withdrawn and discarded and a sterile replacement line is sited: the positioning procedure begins all over again.
Clearly, once a line is in an acceptable position after this intricate positioning procedure, it is essential that the line is securely anchored to avoid any accidental displacement with respect to the infant's umbilicus. The line may need to be


their 2014 World Cup qualifier at a blizzard-bound Hampden Park as both sides ended the game with 10 men.
Defender Grant Hanley gave the home side the lead the against the run of play with a header from a...

Bolivia will resist the temptation to man-mark brilliant Barcelona forward Lionel Messi when they visit Argentina for a 2018 World Cup qualifier on Wednesday (12.30am kick off BST).
'There won't be special marking on Messi,' said coach Julio Cesar...

Gareth Southgate has been highly incentivised to lead England to a highly unlikely World Cup triumph in Russia and a much more realistic opportunity at Euro 2020.
The FA board this week rubber-stamped the new manager's performance-related four-year...communities with other groups of algae and were not cultured on microbiological media, they were studied with traditional phycological methods.Table 1Sampling sitesType of barracksSurface typeMaterialAnalyzed organismsBrick barracksinternal load-bearing wallplastered brickbacteria, mouldspartition wallplastered brickbacteria, moulds, cyanobacteria, algaebunk bedwoodbacteria, mouldsdoor framepaint-coated woodfloorwoodbrickcyanobacteria, algaesoilsand and clay substrateceilingcement-bonded particle boardbacteria, mouldsstrip around the buildingconcretelichensmortarstonescyanobacteria, algaeexternal wallconcrete foundationscyanobacteria, algae, bryophytesmortarbryophytes, lichensbrickdoorwoodcyanobacteria, algae, bryophytesroofroof tilesbryophytesWooden barracksload-bearing wallwoodbacteria, mouldspartition wallplastered brickbeamwoodbunk bedwoodstovebrickdoorwoodbryophytes, lichensstrip around the buildingconcretecyanobacteria, algae, bryophytesmortarlichensstonescyanobacteria, algae

Analysis of microbiological air contamination {#Sec3}
---------------------------------------------

Microbiological contamination of atmospheric air and air inside the barracks was measured by the impaction method using an MAS 100 Eco air sampler (Merck). The total number of bacteria was determined on TSA medium (Tryptic Soy Agar, Merck) with nystatin (0.06 %), and that of fungi on Sabouraud medium with chloramphenicol (Merck). The


were *Staphylococcus equorum* (not present on brick barracks), *Bacillus atrophaeus*, *Bacillus cereus*, *Bacillus mycoides*, and *Streptomyces* sp.*,* while the most widespread moulds included *Aspergillus fumigatus* (not present on brick barracks), *Cladosporium cladosporioides*, *Cladosporium herbarum*, *Alternaria alternata*, *Humicola fuscoatra*, and *Penicillium citrinum*. The microflora of wooden barracks was less diverse than that of brick buildings (Table [3](#Tab3){ref-type="table"}).

Moulds of the genera *Acremonium*, *Cladosporium*, *Penicillium*, and *Chaetomium* have also been isolated from other historical wooden elements (Arenz et al. [@CR1]; Pournou and Bogomolova [@CR37]), as well as from brick and concrete surfaces (Cwalina [@CR7]). Bacteria such as *Achromobacter* sp., *Bacillus* sp., *Clostridium* sp., *Flavobacterium* sp., *Proteus* sp., and *Streptococcus* sp. can colonize concrete materials, bricks, mortar, and natural stone (Cwalina [@CR7]; Warscheid and Braams [@CR49]) as well as wood, also that subjectedtest, P<0.05), we re-ran the analysis excluding this individual; this revealed a significant bias for accepting food from the attempter compared with the non-helper (Student’s t-test, t=2.18, df=5, P=0.046). Direct comparison of frequency of accepting food from B in both conditions confirmed a significant bias against the non-helper (Student’s t-test, t=−2.83, df=5, P=0.019) (Fig. 2). In non-helper sessions, choices of A and B were marginally significantly above and below chance, respectively (one-sample t-test, t=2.14, df=5, P=0.09). Thus, the same tendency to accept food less frequently from the non-helper was observed, albeit less strongly than in Experiment 1.

Explicit non-helper versus occupied non-helper

In Experiment 3, B did not explicitly refuse to help A, but simply failed to acknowledge A’s request. In these sessions, each actor manipulated a container from the


Q:

Making an Ajax call and returning a boolean value in an ASP.NET MVC application

I want to make an ajax call (using JQuery) in an ASP.NET MVC application and return a boolean value, how can I do this?
Thanks

A:

Well, probably the best solution is to use JSON serialization.
public ActionResult DoSomething(string parameter)
    {
        //do something with parameter
        bool result = true;
        return Json(new ActionInfo()
        {
            Success =result,
        });
    }

The ActionInfo is just a{"required": ["matchesFiles"], "not":{"required":["copyAll"]}, "not":{"required":["fileNames"]}},
               {"required": ["doesntMatchFiles"], "not":{"required":["copyAll"]}, "not":{"required":["fileNames"]}}]}
    ]
} ;

This matches more than I want to. I want this to match all of the following:
{"copyAll": true, "unrelatedA":"xxx"}
{"fileNames": ["aab", "cab"], "unrelatedA":"xxx"}
{"matchesFiles": ["a*"], "unrelatedA":"xxx"}
{"doesntMatchFiles": ["a*"], "unrelatedA":"xxx"}
{"matchesFiles": ["a*"], "doesntMatchFiles": ["*b"], "unrelatedA":"xxx"}

but not to match:
{"copyAll": true, "matchesFiles":["a*"], "unrelatedA":"xxx"}
{"fileNames": ["a"], "matchesFiles":["a*"], "unrelatedA":"xxx"}
{"copyAll": true, "doesntMatchFiles": ["*b"], "matchesFiles":["a*"], "unrelatedA":"xxx"}
{"fileNames": ["a"], "matchesFiles":["a*"], "unrelatedA":"xxx"}
{"unrelatedA":"xxx"}

I'm guessing there's something obvious I'm missing - I'd like to know what it is.

A:

The problem is the "not" semantics. "not required" does not mean "inclusion forbidden". It just means that you don't have to add it in order to validate that schema.
However, you can use "oneOf" to satisfy your specification in a simpler way. Remember


opportunities, and emotional distress. See id., ¶ 18. As such,

she claimed, the VA had violated Title VII of the Civil Rights Act of 1964, as amended by the

Equal Employment Opportunity Act, as well as the Rehabilitation Act of 1973. See id., ¶ 19.

She sought compensatory damages to the tune of $300,000 plus interest; an injunction requiring

the VA to permit her to telework three days per week and to provide her with various other

accommodations when at work; an order that the VA restore all the annual and sick leave she has

taken in connection with its failure to accommodate her and that it provide her with excellent

                       accommodations,

restoration of all leave taken as a result of the failure to accommodate, compensatory damages,

attorney fees and costs, and other miscellaneous relief. See id. at 29-36.

         Shortly thereafter, on April 14, 2016, the OEDCA issued a “Rescission of Final Agency

Decision” rescinding the aforementioned FAD. See Pl. Exh. 3 (Rescission Order). The

Rescission Order explained that “[a]fter issuance of the FAD” adjudicating Mavrogianis’s EEO

complaints, “OEDCA received notice that [Plaintiff] had filed a civil action in the U.S. District


     4
Court for the District of Columbia on December 10, 2014.” Id. at 1. Because the claims

Mavrogianis raised in her EEO complaints “are identical to those raised in the Civil Action

pending adjudication before the U.S. District Court for the District of Columbia, as of December

10, 2014, OEDCA had no jurisdiction to render a FAD on this same complaint on March 31,

2016.” Id. It therefore “rescind[ed] in its entirety[] the March 31, 2016 FAD administratively

adjudicating [Plaintiff’s EEO] complaints.” Id. at 2.

       On May 23, 2016, while the parties were in the middle of discovery, Plaintiff filed the

instant Motion for Partial Summary Judgment on her Rehabilitation Act (failure-to-

accommodate) claim citing the factual findings contained in the March 31, 2016, FAD.than mere

unsupported allegations or denials and must be supported by affidavits, declarations, or other

competent evidence, setting forth specific facts showing that there is a genuine issue for trial.

See Fed. R. Civ. P. 56(e); Celotex Corp. v. Catrett, 477 U.S. 317, 324 (1986). The nonmovant is

required to provide evidence that would permit a reasonable jury to find in his favor. See

Laningham v. U.S. Navy, 813 F.2d 1236, 1242 (D.C. Cir. 1987).

III.   Analysis

       Plaintiff appears to concede that her Motion relies exclusively on the FAD issued by the

VA’s Office of Employment Discrimination Complaint Adjudication on March 31, 2016. See

Partial MSJ at 3 (“[O]ur motion is based on findings recently made by DVA’s Office of

Employment Discrimination Complaint Adjudication in a lengthy and definitive


complaint

‘[t]hat is the basis of a pending civil action in a United States District Court in which the

complainant is a party provided that at least 180 days have passed since the filing of the

administrative complaint. . . .’”) (emphasis added); see also Dick v. Holder, 80 F. Supp. 3d 103,

117 (D.D.C. 2015) (“[A]fter 180 days following the filing of an administrative [EEO] charge, if

the agency has not taken final action and no [administrative] appeal has been filed, the

complainant can forgo a hearing and ‘is authorized under . . . the Rehabilitation Act to file a civil

action in an appropriate United States District Court[.]’”) (citing 29 C.F.R. § 1614.407(b)).

       In Johnson, Judge Ricardo Urbina agreed that “[a]n agency must dismiss an EEO charge

whenappraisal for

fiscal years 2013 and 2014.” Rescission Order at 1. The Rescission Order plainly explains that

the Office failed to dismiss the EEO complaints pursuant to Section 1614.107(a)(3) merely

because it was not aware of this case, as it did not “receive[] notice” of the filing of this lawsuit

until after it issued the FAD. See id. at 1.

       Put simply, the OEDCA made a mistake and, just as in Johnson, it is entitled to correct it.

The Court concludes, accordingly, that the VA’s withdrawal of the FAD was appropriate.

Accord Iskander v. Dep’t of Navy, 7 F. Supp. 3d 590, 594 (E.D.N.C. 2014) (“[O]nce the

employee files a federal lawsuit, neither she nor the agency have a duty to continue the

administrative investigation. In fact, the agency is


A model of binge-like eating behavior in mice that does not require food deprivation or stress.
Binge eating disorder (BED) is characterized by excessive food intake during a short period of time and is often associated with obesity. Mouse models of binge-like eating behavior are lacking making it difficult to employ genetic models in the identification of mechanisms regulating excessive eating. We report a rapid and simple model to induce binge-like eating behavior in mice that does not require food deprivation or exogenous stressors. Weekly 24 h access to a nutritionally complete high energy diet (HED), along with continuous access to standard chow, resulted in a significant increase in HED intake following its presentation compared to mice that had continuous access to both diets. Mice exhibiting binge-like eating consumedRodriguez (Stuttgart) – ‘Maza’ played all 90 minutes in the 2-2 draw against Bucuresti and repeated time again in the 2-2 draw against Bremen. Next: Hoffenheim 9/26 Bundesliga; Nurnberg 9/29 Bundesliga

PORTUGAL

Edson Rivera(Braga B)– Wasn’t called up for Leixões.

Finland

Jose Manuel Rivera(RoPS)– Rivera did not play in the 1-1 draw against Jippo. RoPS have already won the Finnish second division and have secured promotion to the Finnish first division.

It seems like Davila’s time has been on and off. One week he’ll play and then the other there’ll be no mention.There’ll probably be more action once Gio comes back. And maybe Jona will go out in January and get playing time elsewhere?

I think what really bugged me was that Gio didn’t debut against Guardado! Not only that, but Guardado didn’t even


ESPN – “Former major league outfielder Manny Ramirez has agreed to terms with the Kochi Fighting Dogs of Japan’s independent Shikoku Island League.”

Guys this is sad. This is Manny Ramirez. The guy who never seemed to give a shit about baseball or his teammates or about much at all seemingly can’t quit the game. Manny was one of the greatest hitters of my generation, maybe of all-time, but the guy was so frustrating. It was like babysitting at times, but in the end it was worth it because when he was going .300/40/140 you’ll put up with a lot of shit. It was just “Manny being Manny.”

The thing about this though is its not like Manny needs the money. And its not like he’s expecting to make apeople racists, NAACP. Certainly you have that responsibility if you want people to take you seriously the next time you call someone racist.

But the most depressing thing about all of this is that Tom Vilsack fired Shirley Sherrod. He fired her. Because of some dumb thing Breitbart vomited on his keyboard! He fired her!

You may remember Tom Vilsack-of-shit as the greatest failure of the 2008 presidential election. This castrato quickly realized that nobody liked him and almost immediately dropped out. But oh no, Tom had campaign debts! So Tom went around asking all the other candidates to pay off his debts in exchange for his endorsement. Hillary Clinton bit. And so, after groveling and kissing her feet, Tom Vilsack spent a year going around telling people how much


call racist? The NAACP will then also call these people racists, and then the Obama administration will see to it that they are fired. That will be much more expedient, and it’s better to do it now while unemployment is high. That way it’s not so distracting, and the people who are wrongly fired will have more company. They can hang out with all the other people who are being fired right now for no good reason! (Saying or writing something that could possibly be objected to is not a good reason for firing someone. This fact apparently has to be said. Over and over.) [YouTube/Salon/Politico/CNN/TPM/NAACP/Weigel]

First off Stuef what are you doing working this late? Second, there are a lot of words to read here. Third, why amfactual account, rather than a matter of opinion, and equally clearly untrue.

Point being, Breitbart is going to keep pulling shit like this until it’s no longer profitable (both in terms of money, and attention/pageviews) for him to do so. If Sherrod has a case, I hope to God she sues him for everything… well, he’s not actually worth all that much, as a human. But I hope she sues, and wins, and gets lots and lots of Breitbart’s filthy racism-money.

PlanetWingnuta

[re=622055]Roger Williams hates your ways[/re]: we aren’t going that far…maybe you need to sit down and lay your head on the desk.

Ducksworthy

[re=621958]iburl[/re]: I forwarded this post to the White House but frankly I no longer care if they read it. Gutless swine kowtowing to the hitlerites among us.

[re=622067]Sgt. Biyatch[/re]:


ahhh thanks. So noted. Now back to Snark & Handjobs on SpikeTV!

Canuckledragger

After Shirley gets her gig back, can Vilsack get ACORN’s funding reinstated? They were the victims of *another* Breitbart fraud, no?

Also, top points for calling that bag ‘o gas “human poop-leech.” The man’s entire ouevre – and social and business circle – consists of fecal matter.

Barrelhse

What a sorry bunch of losers. They make Breitbart look good. Fuck you, Vilsack, you’re a knee-jerk reactionary with both hands on your ignorant ass.

Ducksworthy

Oh My Gawd. This lady has revealed tthe horrible truth about this country that the Southern Strategy is based on but at the same time hopes to hide forever. We are all Niggers to the Owners. There are only two kinds of people in this country. Owners andthe spot to defend themselves when you haven’t yet reviewed the evidence yet or presented it to the audience. This baits them into saying things that might be incriminating when you, as a journalist – or even just an interviewer! – could have simply presented the research you should have done yourself. I don’t care if you follow it up with a clip of the white folks defending her. This kind of interviewing insults the intelligence of the audience. Disgusting. Absolutely disgusting, CNN.

Hint hint, Breitbart: Now is a good time for the rising (sham)conservative political movement to have a “Sistah Souljah” moment. Maybe you should consider being the one who says “we can learn a lesson form this, that we all need to overcome prejudice”, eat a little


very professional with continuity.

Paul (pumpkin trucks Leighs Dad)

WayneScotsmans Pack Hathersage Feb 7, 2013 @ 12:11 PMStrange Days were brilliant. Everybody loved them. They clearly enjoy what they do and they mix in so well with the locals. I lost count of the number of people who came up to me and said that they couldn't believe the sound that came from their voices and instruments. They made a lovely evening into a special one. A great musical band who gave us a really excellent New Years Eve. Wayne Scotsmans Pack Hathersage 31/12/12.

Dennis WakeHORSLEY LODGE Mar 12, 2012 @ 8:00 AM

Kevin, Re Strange Days. I can only repeat the one word which keeps being repeated........BRILLIANT..... and a great time was had by all. Many thanks and regards,Dennis Wake [Hontransfer center (F186) ([Figure 1A,C](#fig1){ref-type="fig"}). This large vertical movement agrees with previous predictions based on cysteine accessibility ([@bib7]; [@bib76]) and voltage clamp fluorometry ([@bib17]). However, the simulations reveal an unexpected break in the S4 helix, causing the C-terminal half to adopt an orientation parallel to the membrane plane ([Figure 1A--E](#fig1){ref-type="fig"}, [Video 1](#video1){ref-type="video"}) when the last gating charge is transferred. Overlay of 6 independent voltage sensors confirms that they converge to the same activated (Down) structure ([Figure 1B](#fig1){ref-type="fig"}, [Figure 1---figure supplement 2](#fig1s2){ref-type="fig"}). This helix breaking model is in stark contrast to what has previously been observed in simulations of voltage-gated potassium channels and new resting state structures of voltage-gated sodium channels ([@bib18]; [@bib5]; [@bib31]; [@bib75]; [@bib68]; [@bib81]; [@bib79]). In these channels, the consensus view is that S4 moves vertically and twists


charges along the membrane normal in a representative voltage sensor measured relative to the charge transfer center (F186). (**B**) Overlay of representative structures of six activated voltage sensors from two independent \~20 µs simulation runs. (**C**) Overall displacement of gating charges (S4 basic residues) along the electric field direction. The box plot shows the median, 25-75% (box), 1-99% (bars) of the data collected from the six voltage sensors that underwent activation. (**D**) A comparison of the bend angles of lower S4 sub-helix with the principal axis of the VSDs of HCN1 and TAX4. HCN1 Up shows the angle between the S4 C-terminus of the HCN1 (PDB 5U6O) and the principal axis of its VSD; HCN1 Down shows the angle between the S4 C-terminus of the simulated structures atgating charge (thick) and the standard error (thin). (**G**) Coupling function corresponding to the resting (cyan) and activated (red) states. The dashed lines depict the boundaries of the transmembrane part of the voltage sensor. (**H**) Hydration of the HCN1 voltage sensor in the resting (left) and activated (right) states. The shaded regions show 25-75 (dark) and 10-90 (light) percentiles of the water molecule number collected for the six voltage sensors that underwent activation.](elife-53400-fig1){#fig1}

###### Conformational changes of the HCN1 voltage sensor during activation.

The S4 helix is shown in cyan, its positively charged residues in different colors (K261 purple, R267 cyan, R270 green, R273 orange and R276 red). The hydrophobic plug (F186) is colored in light green. S3 is gray and the rest of the voltage sensor is transparent.

The movement


simulations, even the charge-transfer center (F186) becomes accessible in 3 out of the six activated states ([Figure 2C](#fig2){ref-type="fig"}). As the charge-transfer center is often considered the boundary between the internal and external crevices, it is an ideal candidate to test for the crevice broadening predicted in our broken helix model. Due to the high expression levels required for assessing internal accessibility with inside-out patches, we used spHCN rather than HCN1 ([@bib48]). The WT spHCN channel shows no detectable functional change following MTSET application to either the closed (depolarized) or open (hyperpolarized) states as has been shown previously ([Figure 2D](#fig2){ref-type="fig"} and [@bib48]). In the charge-transfer center mutant (F186C), internal application of MTSET at depolarized potentials leads to very slowly evolving increase in current amplitude (τ~modification~=7.5±0.5 M^−1^s^−1^). This confirms thatbreak in the center of the helix and a change in the electrostatic environment. Whether this activation mechanism is a hallmark found only in HCN channels or is also present in related families remains to be elucidated. Of particular interest now is to understand the activation mechanism in non-domain swapped ion channels activated by depolarization such as hERG and EAG ([@bib74]) and examine the role of cytosolic domains in modulating voltage-dependence of activation ([@bib80]; [@bib49])

Until recently, all voltage-gated ion channels were also thought to be domain-swapped, with the voltage-sensing domain of one subunit sitting adjacent to the pore domain of its neighboring subunit. Allosteric coupling between the VSD and the pore domain were thought to involve direct contacts between the S4-S5 linker with the C-terminal end of S6


Root mean square deviation (RMSD) of the S5 (top) and S6 (bottom) of HCN1 before (stars) and after (boxplots) MD simulations. HCN1 closed shows the RMSD values with respect to the initial structure of HCN1 (PDB 5U6O); TAX4 open shows the RMSD values with respect to the structure of TAX4 (PDB 5H3O); hERG open shows the structure of RMSD values with respect to the structure of hERG (PDB 5VA1). The arrows indicate the direction along which the HCN1 conformation evolves during activation. For instance, in case of S5, it diverges from the conformation in the HCN1 structure, and approaches that in TAX4 and hERG. (**C**) Network of interactions between the voltage sensor and the pore domain observed in the MD simulations (yellow), separate into two groups: between thethat the mutants are trafficked to the surface membrane. See Figure 3---figure supplement 2A and B.

> Minor points:
>
> 1\) Was the net gating charge of HCN measured previously or only suggested? In its current form it is not clear. If suggested then on what basis? \"The reference net gating charge per VSD is 1.85 e (or 7.4 e per channel), which is in good agreement with the 8 charges per channel suggested previously (Hummert et al., 2018).\"

The net gating charge of HCN2 channel was calculated previously by fitting electrophysiological behavior to a detailed kinetic model. The original language was unclear and we have clarified the sentence to reflect how the experimental charge determination was made.

> 2\) There should be some discussion/explanation that why 6 out of 8 simulations


depend on the charge of the residue. However, we observe no difference between polar residues and charged residues. Moreover, proline which lacks any charge but promotes helix disruption promotes inverted gating phenotype like the serine at that position. We should also point out that we observed strong correlation between turn propensity and gating polarity. To the best of our knowledge, such correlations have never been observed when considering interactions between lipid molecule and amino acid side-chains.

> The cysteine accessibility studies are used to highlight that F186C is exposed in the HCN1 down state, which is inconsistent with helical screw model. It would be helpful to have a series of positions that show that the helical-breaking model is correct instead of primarily showing that the helical screw model isPatrick Smith/Getty Images

The long wait is almost over. The Green Bay Packers and Indianapolis Colts kick off the preseason with the Hall of Fame Game Sunday night to begin a stretch of six straight months of NFL action before a champion is crowned in Houston next February.

Three tiers of teams head into the campaign: the likely contenders, the muddled middle and the long shots. What's intriguing about this season is the lack of a clear-cut favorite, at least for now, and the increased size of the middle of the pack outside of the top seven or eight teams.

So let's check out an initial set of power rankings before the preseason gets underway. That's followed by a closer look at the top squads as the new season inches closer.

Preseason


(11/3)/(1/(-3)). Let s = i + b. Does 7 divide s?
False
Let a(j) = -6*j - 26. Let c be a(-6). Suppose -4*o + 242 = -c. Is 14 a factor of o?
False
Let b(g) = -g - 3. Let a be b(-5). Suppose 2 = -a*o, -2*i + 3*i + 2*o = -1. Is 5 a factor of i*3*98/21?
False
Let q(x) = -x**3 + 13*x**2 + 20*x - 14. Let c(b) = 2*b**2 + 9*b + 18. Let f be c(-4). Does 11 divide q(f)?
False
Suppose -3*g - 6*p + 1713 = -8*p, -2*p = 0. Does 26 divide g?
False
Let n(a) = 5*a**2 + 2*a + 8. Let q be n(4). Suppose -12 = 3*m - q. Is 7 a factor of m?
True
Let n be -197 + 3 + 4/2. Letentity, validation is done as well, so you can never create an entity in an invalid state.

A:

One of the DDD principles encourages domain entities to have only private setters and a private default constructor, to make sure you cannot create domain entities in an invalid state.

That's not quite right.  Yes, rich domain models don't usually expose setters, but that is because they don't need setters.  You tell the model what to do at a higher level of abstraction, and allow it to determine how its own data structures should be modified.
Similarly, there are often cases where it makes sense to expose the default constructor: if you think of an aggregate as a finite state machine, then the default constructor is a way to initialize the aggregate


Peterhouse, the Royal Society and molecular biology.
The term molecular biology was coined by Warren Weaver, a mathematician who was head of the natural sciences section of the Rockefeller Foundation, in his report to the president of the Foundation in 1938. The origins of the subject may be located in various places or periods, but Sir Peter Medawar used to argue that it was Sir William Bragg and W.T. Astbury at the Davy Faraday Laboratory in London who began it, when they investigated the structures of materials such as silk, wool and hair by X-ray diffraction. Others say that J.D. Bernal was the progenitor. Peterhouse, a Cambridge college, was a hothouse of the subject.period of time (after approximately 10 h process duration) and spontaneously break when they are slightly shaken or touched. The Ep-A2 272 418 discloses, for example, such a method and an arrangement suitable therefor. Therein, using a thermal CVD-process diamond particles are deposited from a carbon/hydrogen atmosphere onto a substrate which is heated to a temperature in the range from 1000.degree. to 2500.degree. C. and consists of a high melting metal or carbon, the reaction gas being excited by means of a tungsten heat conductor having a temperature of 2000.degree. C.
Because it is so simple, this method, in which the gas phase is excited via a heated resistance wire (alternatively denoted "filament method" in the relevant literature), is at present one of the most widely used processes for


between requesting clients and the origin servers that process the client requests. In this manner, proxy servers provide a centralized point of ingress and egress for network traffic in a web-based application network infrastructure and enable the implementation of various network policies or functions at the proxy in order to reduce processing demands on the origin servers, manage the flow of network traffic, and gain insights into system behavior. Examples of policies or functions include caching, diagnosing error conditions, load balancing, and authentication, and authorization.
Certain proxy servers are primarily implemented as application software that runs on a server and are generally configured for specific situations. However, existing proxy server applications have a number of disadvantages. For example, existing proxy server applications provide primarily for the specification of staticallyOptimizing spatiotemporal sampling for k-t BLAST and k-t SENSE: application to high-resolution real-time cardiac steady-state free precession.
In k-t BLAST and k-t SENSE, data acquisition is accelerated by sparsely sampling k-space over time. This undersampling in k-t space causes the object signals to be convolved with a point spread function in x-f space (x = spatial position, f = temporal frequency). The resulting aliasing is resolved by exploiting spatiotemporal correlations within the data. In general, reconstruction accuracy can be improved by controlling the k-t sampling pattern to minimize signal overlap in x-f space. In this work, we describe an approach to obtain generally favorable patterns for typical image series without specific knowledge of the image series itself. These optimized sampling patterns were applied to free-breathing, untriggered (i.e., real-time) cardiac


imaging with steady-state free precession (SSFP). Eddy-current artifacts, which are otherwise increased drastically in SSFP by the undersampling, were minimized using alternating k-space sweeps. With the synergistic combination of the k-t approach with optimized sampling and SSFP with alternating k-space sweeps, it was possible to achieve a high signal-to-noise ratio, high contrast, and high spatiotemporal resolutions, while achieving substantial immunity against eddy currents. Cardiac images are shown, demonstrating excellent image quality and an in-plane resolution of approximately 2.0 mm at >25 frames/s, using one or more receiver coils.the simulated sound source positions are shown by *open triangles*

The stimuli consisted of speech, music, and broadband noise. One speech stimulus was a sentence spoken at a conversational level by a male, randomly selected from the Bench--Kowal--Bamford corpus (Bench et al. [@CR5]). The sentence was sampled at 22.05 kHz and had a duration of 1.5 s, chosen to match stimuli previously used in a distance discrimination study with sighted participants (Akeroyd et al. [@CR1]). Music stimuli consisted of a 7.3-s segment of a jazz trio (piano, bass and drums) sampled at 22.05 kHz, previously used to investigate the influence of upper cutoff frequency on preferences for music using hearing aids (Moore et al. [@CR39]). Noise stimuli were broadband (0.6--12 kHz) white noise bursts with 90-ms duration and 10-ms rise/fall time, sampled at


participants and blind participants with light perception only were asked to close their eyes and walk forwards over the predetermined distance. No feedback was given.

Figure [4](#Fig4){ref-type="fig"} shows geometric mean walked distances for sighted and blind participants. Walked distances were similar for sighted and blind participants for all three target distances. The mean unsigned error was assessed using a mixed-model ANOVA with distance as a within-subjects factor and blindness as a between-subjects factor. The main effect of distance was significant \[*F*(2, 32) = 4.35, *p* \< 0.05\], but there was no main effect of blindness or interaction (both *p* \> 0.05), suggesting that the differences across groups observed in the main experiment were not due to differences in general ability to judge distance between sighted and blind participants.Fig. 4Geometric mean walked distances for sighted participants (*open bars*) sfonerra'Precinct, who shall hold offfce for
                 a term of two years. The time for such elec-
                 tfon shall be the first Saturday In April of
                 each year? the order for the electfon of coun-
                 ty school trustees to be made by the county
                 judge at least thirty


game. This makes the game enjoyable enough for anyone playing it just for fun. An awesome feature in Mega Moolah slot is that most players like most about it is the multiple jackpots available to any player which means that it is difficult to walk away empty- handed when you get the chance to take on the jackpot wheel which appears randomly to any player.

The Game and Its Features

Mega Moolah slots is a five reel, three rows and 25 pay line game that you can bet very little amounts of $0.01 to play a single spin. How much you bet will tell how many coins you get which will control the number of pay lines at your disposal and as you may know, having more pay lines isFriday, June 25, 2010

This week I heard a message about Church: What Makes Church? It was presented by Ergun Caner at SuperWow in Ft. Walton.

It was based on Mark 2:1-12. This is the story of the paralyzed man who is let down through the roof by 4 friends who want Jesus to heal Him.

Here are the 4 things that make church:

1. Jesus was in the midst. He needs to be there. That is what makes church "church": The Presence of Christ!

2. He preached the Word to them. This is in verse 2. "and He preached the Word to them." We don't know exactly what He talked about. But it was a big crowd, hanging out the door.

3. People were bringing their friends. These friends were Warriors. And there


Q:

Android: Checking if URL has new image data

Here's my situation : -
1. I have a url that contains an image(e.g http://someSite.newImage.png).
2. The url is constant even if I change the image online because I upload new images with same image name(e.g newImage.png), making the url the same but with a different image on each upload.
3. I use the 'InputStream' method to open the url to load latest image in the onCreate method of my activity.
What I want to achieve  : -
I want my app to be able to detect new image uploads from the url and update my 'ImageView' with latest image while the app is running(currently it only updates my 'ImageView' when the app is first started) and also be able to show maybe[Complex injuries of the proximal humerus treated with humeral head prosthesis. Apropos of 21 cases reviewed after a median 4-year follow-up].
Of a total of 35 complex fractures of the upper humeral epiphysis treated by Neer arthroplasty, 21 were evaluated at a mean of 4 years after operation. The shoulder function according to Constant was 70% of the contralateral one. The internal and external rotations were rarely symmetric. Clinical improvement was possible during the first 2 years. Late breakage and migration of wires used to fix the tuberosities caused failure of this method of fixation. Dynamic radiographs revealed significant gleno-arthroplastic movement and a constant medialization of the prosthetic humerus.


Grunnet *et al*. observed an effect of Bax activity on cytokine‐induced beta cell apoptosis in INS‐1 cells and human islets [6](#jcmm12876-bib-0006){ref-type="ref"}. Consistent with the results of a study by Grunnet *et al*., in a previous study, we also found that in TNF‐α and IFN‐γ‐induced NIT‐1 cells, Bax expression is remarkably up‐regulated, while Bcl‐2 expression is gradually down‐regulated [4](#jcmm12876-bib-0004){ref-type="ref"}. In this study, our results show altered expression of Bcl‐2 family proteins (including Bcl‐2, Bcl‐xL, Bax, and Bak) in LIGHT and IFN‐γ‐treated MIN6 cells and islets of prediabetic NOD mice with peri‐insulitis. The increased expression of pro‐apoptotic molecules Bax and Bak, and decreased expression of anti‐apoptotic molecules Bcl‐2 and Bcl‐xL may play an intermediate role in LIGHT and IFN‐γ‐mediated mitochondrial dysfunction in MIN6 cells. The differences among these studies mayinterests, and you’re just craving intense gameplay, “Ultimate Mode”, offers you up over twenty random, original story arcs where you’re in control of your pilot and Gundam. This feels a little less polished than Official Mode, but with it being less structured and more up to you, that isn’t exactly surprising. And they still manage to use a connective theme through each story arc too (emphasis on time, killing enemies, stealth, etc.) If anything else, it’s pretty deliriously delightful to see Gundams from all eras intermingling anachronistically, as all-out warfare breaks out. This also goes to some lengths to adding replay to the game, as you customize these missions as you see fit. There is a weird degree of focus on the Gundam SEED series, which feels more


solely out of passion in response to a provocation that would have caused a reasonable person to act as he did. Smith v. State, 271 Ga. 507(2), 521 S.E.2d 562 (1999). Appellant did not testify that he was angry when he shot Glenda. Rather, appellant testified that he was trying to calm Glenda down by demonstrating that the gun would not fire. In doing so, appellant testified he pointed the gun at the windshield and pulled the trigger, thinking the gun would not fire until the trigger was pulled a second time. Appellant testified that as he pulled the trigger, Glenda jerked his hand away toward her, and the gun fired. Thus, in the absence of evidence of provocation and passion, the trial court did not err in16-2-2. The context in which the phrase "satisfactorily appears" is used does not in any way refer to the State's burden of proof. Thus the charge was not, as appellant contends, an inaccurate statement of the State's burden of proof.
4. Appellant argues the trial court erred in failing to charge the jury sua sponte on self-defense with respect to the crimes committed against Glenda Smith and Tonya Smith. It is error to fail to give a charge on a defendant's sole defense, even where the defendant does not request the charge, if there is some evidence to support the charge. Bowden v. State, 270 Ga. 19(3), 504 S.E.2d 699 (1998). We conclude that the trial court did not err in failing to charge the jury on justification with


13 kb apart on chromosome 6p21. One SNP (TNFA-308G>A) showed a significant association with the risk of asthma (P=0.0004). The frequency of TNFA-308A allele-containing genotype in asthmatics (9.8%) was much lower than that in normal controls (22.9%). The protective effects of this polymorphism on asthma were also evident in separated subgroups by atopic status (P=0.05 in non-atopic subjects and P=0.003 in atopic subjects). The most common haplotype of the TNF gene (TNF-ht1[GGTCCGG]) was associated with total serum IgE (immunoglobulin E) levels in asthma patients, especially in non-atopic patients (P=0.004). Genetic variants of TNF might be involved in development of asthma and total serum IgE level in bronchial asthma patients. The results of this study could be helpful to understand the function of important TNF genes in asthma andDINOSAURS – PICTURES AND FACTS

Listing 10.000+ pictures of dinosaurs, facts about them and other prehistoric animals, bringing them closer to kids, their parents and teachers.

Carcharodontosaurus

Quick Carcharodontosaurus Facts

Could swallow a human in one bite

Could run about 25 MPH

As long as four car links

Weighed as much as 2 Asian Elephants

Teeth as long as a butcher knife

About Carcharodontosaurus

Carcharodontosaurus is a dinosaur that lived approximately 100 million years ago during the mid- Cretaceous Period. It was first discovered in 1927 by Charles Depéret and J. Savornin in Northern Africa. When it was first discovered, it was originally named Megalosaurus saharicus, but was later changed by Ernst Stromer von Reichenbach to Carcharodontosaurus in 1931. This was done because the teeth reminded him of the teeth of the shark genus Carcharodon. It’s name literally


the designers consider dark/black colour themes, which are
not only more easier on the eyes, but also notably save the battery.

~~~
virmundi
Dark themes are worse for the eyes,
[https://ux.stackexchange.com/questions/53264/dark-or-
white-c...](https://ux.stackexchange.com/questions/53264/dark-or-white-color-
theme-is-better-for-the-eyes)

Don't know about battery life. I guess if it's AMOLED,
[https://www.greenbot.com/article/2834583/how-much-power-
does...](https://www.greenbot.com/article/2834583/how-much-power-does-a-black-
interface-really-save-on-amoled-displays.html)

~~~
shostack
Maybe, but I wonder if that is true at night with the lights off. When I read
in bed at night, I _much_ prefer light on dark text. Combined with Android's
night mode to tint things red, it is fantastic.

In fact, I wish the Kindle Paperwhite would come out with an inverted mode
already (although I think I read there were some challenges with doing so). It
can be fairly straining on my eyes to have the sidelit screen bright enough to
be legible while being as dim as possible to make reading with the lights off
comfortable.

~~~
orky56
Majority of readingexactly is changing? From the screenshots from the reddit
post about it, it looks.... like reddit. There's posts and the posts have
upvote/downvote buttons, and there's a link to the comments that shows how
many there are. Am I missing something? The OP article doesn't actually have
any screenshots of changes, and I made it several paragraphs into the article
still not understanding what is changing.

~~~
strifey
You should be able to interact with the redesign directly at
[https://new.reddit.com](https://new.reddit.com). The main complaints I've
seen leveled at the redesign are: user profiles becoming more like Facebook
profiles, the new chat functionality missing core features, and the newly
created "best" ranking becoming the default.

~~~
joemi
Not sure why, but that link just brings me to the normal homepage (as it's
looked for years).

~~~
Fifer82
This confused me as well. See Izkata below your comment with a


-- reddit is ugly but people are
used to it that way and grew to like it. The redesign is for new users.

Reddit has already been down this path with Pao. If they don't like how the
site is being run they will depart or revolt.

~~~
gedy
> The redesign is for new users

And I suspect bigger, more visible ads/paid content

~~~
FridgeSeal
The paid content is definitely way worse (more insidious) in the new design):
it blends in far more, and equally as bad is that a lot of it seems to be just
using those trash fb-esque style clickbait titles.

Reddit's not perfect, but trash-tier clickbait titles is not something I'm
accustomed to seeing on there, nor do I want to.

------
crankylinuxuser
I unfortunately saw this weeks ago. I did the checkbox accepting being in the
Beta program.

At first, Ithey need
to be enabled by the mods.

------
Redoubts
All I wanted to see is what the comments section now looks like. It's
literally the only thing I'm there for, and preview photos never show it. (My
biggest complaint with many HN app previews too)

Of course, when I try the preview myself, I'm greeted with this:

[https://imgur.com/a/PvRhk](https://imgur.com/a/PvRhk)

~~~
teddyfrozevelt
Here's an example.

[https://imgur.com/a/RfioM](https://imgur.com/a/RfioM)

~~~
shostack
I'm not seeing any significant differences there. Am I missing something
obvious?

------
brynjolf
Frustrating to discuss this on reddit as well. They always think we should
watch and eait but that rarely works. Especially if they already added huge
banners advertising their data collecting app and now autoplaying videos,
before people complained they also autoplayed them with sound..

------
nhangen
How can an article about a re-design not actually show or compare the two
designs?

~~~
Consultant32452
[https://www.wired.com/story/reddit-
redesign/](https://www.wired.com/story/reddit-redesign/)

This one at least has some screenshots of the new design. It


feels like a
Facebook clone to me. In particular it looks like they're flattening comments
to be like FB rather than the thread? model that Reddit has today.

~~~
relin
The only significant change I've noticed re: comments are how the nested
chains collapse: instead of the intuitive [+] and [-] at the parent comment,
there's a line that runs alongside the chain. Click that line and it
collapses.

It's not as easy to figure out on your own, but it's a significant improvement
IMO.

------
adjunctme
The redesign adds a bit of lag from all the javascript and extra elements. The
old plain text + expanding comments + images/gifs is much smoother and
includes everything that's needed

------
atupis
There is certain design by committee feeling at new redesing, its like they
are putting everything there chat, share, follow, fancy sidebar, options and
more.

------
bkovacev
Reddit is pushing tomistake or by design?

~~~
akerro
There are no mistakes in it. This was planned years ago, they spent a lot of
time evaluating different technologies and UI mockups. I'm interested to see
if AMA with Barak Obama will be still readable, or will start consuming
gigabytes of RAM.

------
chaoticmass
I miss being able to collapse comments by pressing the minus-sign button.

~~~
noxToken
The long bar (beneath the upvote/downvote buttons) that shows what level the
current comment is at collapses comments by clicking it. Very unintuitive, and
I only found it by accident.

~~~
chaoticmass
ah, thanks... but yes, very unintuitive.

------
spiderfarmer
The Apollo app is what official Reddit should be like right now.

~~~
FridgeSeal
Or Reddit Sync.

------
sidkhanooja
Reddit has its issues (brigading, trolling, execssive politics, 12-year old
level "memes" on serious discussions), but it was a site you could visit
without regret, and get lost in for hours.

With the


models in memory constrained environments.

    concludes our work showing that online grammar extractors and neural language models allow us to build scalable, high quality systems that can translate text with the limited resources available on a mobile device.
author:
- 'Paul-Dan Baltescu'
bibliography:
- 'mybib.bib'
nocite:
- '[@Baltescu2014extractor]'
- '[@Baltescu2014oxlm; @Baltescu2015]'
title: |
    Scalable Machine Translation in\
    Memory Constrained Environments
---

plus1pt

Introduction {#chapter:intro}
============

Machine translation is the discipline concerned with developing automated processes for translating from one natural (human) language to another. Although machine translation has been a subject of interest in the research community since the late 1940s [@Weaver1949], the field has only seen significant progress since the 1990s with the rise in popularity of statistical methods for translation [@Brown1993]. Statistical machine translation makes use of parallel data toof boosting translation quality further.

In , we show that by combining the techniques introduced in the earlier chapters, we obtain a high quality system that fits within the 1 GB memory constraint. We evaluate our system on three language pairs and show that it outperforms a traditional system trained on sampled data to match the memory requirements by 0.7-1.5 BLEU points. The proposed techniques are scalable both when training the model and when using it to decode new sentences.

Another important contribution of our thesis is that we open source our code and make it easy to integrate with the most popular translation toolkits. Our suffix array grammar extractor[^1] is released as part of cdec [@Dyer2010] and has been included as part of the default instructions for building a


their raw form, because they cover an insignificant part of the space of sentence pairs. The observed sentence pairs are also unlikely to repeat again. Therefore, we need to use the parallel data to learn smaller translation units which can later be composed in order to translate full sentences. Alignment models help with this crucial task by learning the process of translating (or aligning) single words. Larger translation units can then be obtained by composing several aligned words located in the same context ().

![Alignment matrices are a visual interpretation of word alignments for a pair of sentences. In this image, one can notice that the alignment links follow the general direction of the main diagonal, a common trait for Indo-European languages. The alignment matrix also illustrates different syntacticpredecessors, phrase-based models can translate contiguous groups of words (phrases) in a single step. The intuition behind these models is that if a phrase pair is observed enough times in the parallel corpus, it is more likely to produce the intended translation than if we replace individual source words with their most likely translations. Another reason why phrase-based models perform better is their ability to capture local reorderings and to improve grammatical agreement.

![The three step process for translating with phrase-based models.[]{data-label="figure:translation_process"}](translation_process)

At a high level, phrase-based translation can be seen as a three steps process: first, the source sentence is segmented into several phrases, then each source phrase is translated into a target phrase, and finally, these phrases are reordered to produce a fluent translation in the target language


\rightarrow X_1 X_2\ |\ X_1 X_2$ and $X \rightarrow X_1 X_2\ |\ X_2 X_1$. A number of other permutations may be obtained by repeatedly applying these two rules, but not all (e.g. $X \rightarrow X_1 X_2 X_3 X_4\ |\ X_2 X_4 X_1 X_3$). Although the number of permutations that cannot be obtained with this procedure increases exponentially with the size of the permutation [@Wu1997], show that only a negligible part of real world reorderings cannot be captured with this simplified model.

A number of translation models use the SCFG formalism: inversion transduction grammars [@Wu1997], hierarchical phrase-based models [@Chiang2007], syntactic tree-to-string grammars [@Galley2004; @Galley2006], etc. We briefly describe hierarchical phrase-based models because of their relative success over phrase-based models. The cdec toolkit [@Dyer2010] relies by default on a hierarchical phrase-basedpositive outputs and learns a set of weights $\lambda_1^K$. The weights $\lambda_1^K$ capture the correlation between the feature functions and the model’s output: a large positive $\lambda_k$ implies the function $f_k$ is a strong predictor of the model’s output, a large negative $\lambda_k$ shows a strong inverse correlation between $f_k$ and the model’s predictions, while a $\lambda_k$ close to 0 shows that $f_k$ is not useful for predictions. The feature functions $f_1^K$ typically include a target language model and a generative target-to-source translation model, just like generative scoring models. However, since log-linear models support overlapping features, it is common to also include a source-to-target generative translation model, to use several scoring techniques for translation models (e.g. word level, phrase level, word embeddings) or to include multiple target language


not degrade the quality of the decoder.

![A subset of the derivations applied by a phrase based decoder with a 3-gram language model to translate the sentence *La discussion commune est close*. The decoder states are stacked in priority queues based on the number of source words translated so far. The transition (10000, $\langle$s$\rangle$ the) $\rightarrow$ (10100, the joint) illustrates a reordering applied by the decoder, where the word *discussion* is left to be translated later. The transitions (00000, $\langle$s$\rangle$ $\langle$s$\rangle$) $\rightarrow$ (11100, joint debate) and (10100, the joint) $\rightarrow$ (11100, joint debate) and, respectively, (11000, the debate) $\rightarrow$ (11100, debate joint) and (11000, $\langle$s$\rangle$ debate) $\rightarrow$ (11100, debate joint) illustrate the hypothesis recombination trick. In the first case, the same translation *the joint debate* is generated by two   8       5
   h’$_3$   1     6
  -------- --- ------- ------- -------

In order to make SCFG decoders practical, we apply an optimization trick similar to beam search known as cube pruning. For each pair of source indexes $(i, j)$, we stack the partial hypotheses (identified by their two $n-1$ target word histories) in a priority queue. As with beam search, only the top candidates from each priority queue are analyzed, hypotheses below a certain index or a certain score threshold are discarded. The additional complexity for decoding with hierarchical phrase-based models is that a hypothesis can


step repeats the operations in the second step, but this time focusing on the word *eats*. Note that in this example we show the suffix array explicitly, but the actual algorithm executes these steps on the compact representation shown in .[]{data-label="figure:contiguous_matching"}](suffixarray)

The algorithm for finding the occurrences of a phrase in the parallel corpus uses binary search to locate the interval of suffixes in the suffix array starting with that phrase pattern. Let $w_1, w_2, \ldots, w_K$ be the phrase pattern. Since a suffix array is a sorted list of suffixes, we can binary search for the interval of suffixes starting with $w_1$. This contiguous subset of suffix indices continues to be lexicographically sorted and binary search can be used again to find the subinterval of suffixes starting withshowed why online grammar extractors are a natural choice for the task of constructing an autonomous translation system that can run on a commodity machine or on a mobile device. We first reviewed how suffix array grammar extractors work in phrase-based translation systems and then introduced a novel extraction algorithm for hierarchical phrases that is 4 times faster than . We provided details on our open source implementation and showed how to maximise parallelism without any negative impact on the memory footprint. Finally, we presented several experiments illustrating the benefits of the approach we proposed in this chapter.

Neural Language Models {#chapter:nlms}
======================

Introduction {#introduction-2}
------------

Most translation systems today use standard back-off n-gram models to model the target language. We showed in that traditional n-gram models estimate and store a weight for


every n-gram in the training data. The amount of data used to train language models has significant impact on the overall translation quality. Monolingual data is cheap to obtain and it has become a standard to train language models on corpora consisting of billions of words. On these large corpora, even the most compact implementations of n-gram models require many gigabytes of memory, making them unsuitable for memory constrained environments.

In this chapter, we focus on neural language models as a compact alternative to traditional n-gram models. Neural language models [@Bengio2003] are a more recent class of language models which use neural networks to learn distributed representations for words. Neural language models project words and contexts into a continuous vector space. The conditional probability $P(w_i | w_{i-n}^{i-1})$ is definedand tree factored models are slow compared to unnormalized models. One option for speeding up factored models is using a GPU to perform the vector-matrix operations. We did not explore this option since GPU implementations are architecture specific and would limit the usability of our open source toolkit by the community. Overall, if quality is more important than speed, we recommend using class factored models; otherwise, we recommend using unnormalized models.

Noise Contrastive Training {#section:nlms:noise_contrastive}
--------------------------

Training neural language models to maximise data likelihood involves several iterations over the entire training corpus and applying the backpropagation algorithm for every training sample. Even with the previous factorization tricks, training neural models is slow. We investigate an alternative approach for training language models based on noise contrastive estimation, a technique which does not


   32.89
            1               12 GB       33.01

  : BLEU scores and memory requirements for back-off n-gram models constructed from different percentages of the training corpus.[]{data-label="table:acceptance_ratio"}

In this section, we compare neural language models and back-off n-gram models on a wide memory spectrum and track how the end to end quality of a translation system changes as these models grow in size. We perform this analysis with two goals in mind. First, we seek to verify the hypothesis that neural language models are indeed better suited for memory constrained environments. Second, we aim to understand how neuralaround $\bar{a}_i$. Specifically:

-   If $t_i$ has a single alignment link $a_i$, then $\bar{a}_i = a_i$.

-   If $t_i$ has multiple alignment links, $\bar{a}_i$ is chosen to be the middle alignment link. In case of an even number of alignment links, we choose the middle link to the left.

-   If $t_i$ is unaligned, we set $\bar{a}_i = \bar{a}_j$ where $t_j$ is the closest aligned target word to $t_i$. In case of ties, preference is given to the target word on the right.

Using these notations, the conditional probabilities become: $$P(t_i | t_1^{i-1}, \textbf{s}, \textbf{a}) = P(t_i | t_{i-n}^{i-1}, s_{\bar{a}_i - m}^{\bar{a}_i + m}).$$

![A source conditioned neural language model with $n=3$ and $m=1$ predicting the word following the target context *the cat* using the source window


altogether. We observe that class factored models are best in terms of translation quality, while unnormalized models are (unsurprisingly) the fastest. The clustering algorithm used to partition the target vocabulary into word classes has considerable impact on quality. In this respect, our experiments show that Brown clustering [@Brown1992] clearly outperforms frequency binning. Next, we review noise contrastive training, an effective optimization trick which allows us to skip the normalization step at training time with negligible loss in BLEU score, and show how this technique can be extended to class factored models. We also investigate diagonal context matrices for speeding up the computation of the hidden layer of the neural network. We compare our best performing neural language model with a compact n-gram language model on a wide memoryis always `eval` `Identifier` (or possibly
         * `Literal`). The type of the report is `CallExpression` if the parent is
         * `CallExpression`. Otherwise, it's the given node type.
         *
         * @param {ASTNode} node - A node to report.
         * @returns {void}
         */
        function report(node) {
            const parent = node.parent;
            const locationNode =


           reportAccessingEvalViaGlobalObject(globalScope);
            },

            FunctionDeclaration: enterVarScope,
            "FunctionDeclaration:exit": exitVarScope,
            FunctionExpression: enterVarScope,
            "FunctionExpression:exit": exitVarScope,
            ArrowFunctionExpression: enterVarScope,
            "ArrowFunctionExpression:exit": exitVarScope,

            ThisExpression(node) {
             Peculiarities of intracellular regeneration of cardiomyocytes during plastic myocardial insufficiency.
We performed morphological assay of the myocardium in Wistar rats with anthracycline cardiomyopathy and SHR rats with genetically determined arterial hypertension causing hypertrophic cardiomyopathy. Both disorders were accompanied by a decrease in protein synthesis and development of plastic cardiomyocyte insufficiency. Electron microscopy revealed peculiarities of intracellular regeneration of cardiomyocytes. We observed disorientation of newly formed myofibrils lying between preserved myofibrils. These myofibrils were positioned perpendicular or at angle to the long axis of muscle fibers, or extended from the Z line (in a fan-like manner) crossing each other. Regeneration disturbances also included excessive elongation of myofibrils. These abnormalities of myofibril regeneration were related to changes in transcription and translation in cardiomyocytes, due to DNA damages caused by cardiotoxic doses


could conduct an autopsy on my brother. The autopsy was performed well in the village and the Kuru Project then assisted with the funeral preparations.

Today, it looks as though kuru has nearly disappeared, but other common diseases such as malaria, TB, typhoid, asthma and AIDS are claiming innocent lives in Okapa District. If an opportunity arises for medical scientists to work on other diseases in our district, we would be very happy.

In some of the villages where medical scientists once worked, kuru research is still being conducted and those of us who understand the importance of the work are happy to collaborate to help future generations of Papua New Guineans.

In conclusion, I thank the early kuru researchers for their work and for helping us to change our culturalsimilar to that seen in other protein kinases while the regulatory domain is unique to the PKC isozymes. The PKC isozymes demonstrate between 40-80% homology at the amino acid level among the group. However, the homology of a single isozyme between different species is generally greater than 97%.
Protein kinase C is a membrane-associated enzyme that is allosterically regulated by a number of factors, including membrane phospholipids, calcium, and certain membrane lipids such as diacylglycerols that are liberated in response to the activities of phospholipases. Bell, R. M. and Burns, D. J., J. Biol. Chem. 266: 4661-4664 (1991); Nishizuka, Y. Science 258: 607-614 (1992). The protein kinase C isozymes, alpha, beta-1, beta-2 and gamma, require membrane phospholipid, calcium and diacylglycerol/phorbol esters for full activation. The delta, epsilon, eta, and


significantly increases the use of health resources and services.[@b4-ceor-8-235],[@b5-ceor-8-235] House dust mites are one of the most common airborne allergens worldwide, with great capacity to cause sensitization. Their involvement in rhinitis, asthma, or other allergic diseases is widely known.

Specific immunotherapy (IT) has the potential to alter the course of allergic disease, thus reducing the need for long-term treatment and the risk of progression of allergic disease[@b6-ceor-8-235],[@b7-ceor-8-235] or the development of new sensitizations,[@b4-ceor-8-235],[@b5-ceor-8-235] in contrast to symptomatic treatment.

International studies suggest that IT compared to drug therapy is cost-effective for patients with rhinoconjunctivitis and/or asthma. Other studies also show that treatment with additional specific subcutaneous immunotherapy (SCIT) brings better health outcomes and associated cost savings compared to symptomatic treatment alone.[@b8-ceor-8-235]

A piggy-back study involving 65 children and adolescents with allergic asthmamajor protocol deviations and had completed at least 9 months of treatment from the administration of the first maintenance dose. The study was approved by the Ethics Committee at the Hospital Puerta del Mar in Cádiz, Spain on March 13, 2013 and classified by the Spanish Medicines Agency. Written informed consent was obtained from patients or legal guardians.

Statistical analysis
--------------------

The data analysis was performed using the Statistical Package SAS System for Windows (SAS Institute Inc., Cary, NC, USA). In all statistical tests with outcome variables, a level of 0.05 was considered significant except for preliminary tests of normality or homogeneity of variance, for which a significance of *0.1* was used. Friedman's test was performed to compare the evolution over time of symptoms and medication (scheduled and used) after 1


instead of $t$ a new integration variable

$$q=\Delta z\sqrt{{t^2\over l(l+1)}+V(z)}$$

and rewrite these terms in the form

$$\Delta z^{n-1}\int_{\Delta z\sqrt{V}}^{\infty}{{dq\over
 q^{(n-1)}\sqrt{q^2-\Delta z^2V}}\left (-{d\over dq}\right )
^{2m+1-n}{f(q)\over q^2}}$$

where

$$f(q)\equiv q^2\sum_{l=1}^{\infty}{\left (l+{1\over 2}\right )
\exp{\left [-q\sqrt{l(l+1)}\right ]}}.$$

The $f(q)$ is regular at $q\geq 0$. It turns out that coefficients in $T_{\mu\nu}^{\rm reg}$ at $\Delta z^{-n}$, $n=0,
1,2,3,4$ and at $\ln{(L/\Delta z)}$, $L={\rm const}$, in the considered quasiclassical orders can be expressed in terms of $f^{(m)}(0)$, $m=0,1,2,3,4$. In turn, the latter are elementary calculable by taking into account a few first terms in the expansion of $\sqrt{l(l+1)}$ in the last formula over decreasing powers of $l+1/2$ [@Kh].

The result of calculations made according to the above scheme gives for the two basic integrosums entering (\[T-mu-nu\]):

$$\begin{aligned}
\sum_{l=1}^{\infty}{\int_{0}^{\infty}{\left (l+{1\over 2}
\right )dt\,l(l+1)G}}&=&{2\over\Delta z^4}{1\over V^2}-{2\over
\Delta z^3}{V^\prime\over V^3}+{1\over\Delta z^2}\left ({7
\over 4}{V^{\prime 2}\over V^4}-{5\over 6}{V^{\prime\prime}
\over V^3}\right )\nonumber\\
&&\hspace{-0.5cm}-{1\overfundamental facts and principles about the identity, diversity, and activity of naturally occurring microorganisms involved in the metabolism of PAHs. This goal will be achieved by five major aims integrated around new, novel molecular and analytical chemistry 3rocedures that rely on 13C-labeling techniques. The five major aims are: (i) identifying active populations Jsing a stable isotope probing (SIP) technique that traces the flow of 13C-labeled PAHs into the DNA of soil microbial populations--the procedure supplies 13C-labeled PAHs to soil, extracts microbial community DNA, separates 13C- from 12C-DNA via CsCI ultracentrifugation, and then the 16S rRNA genes present in the 13C-DNA fraction are amplified by PCR, cloned, and sequenced; (ii) verifying the PAHs are metabolized using gas chromatography/mass spectrometry to monitor the conversion of 13C-PAHs to 13CO2; (iii) ascertaining


Sarkozy was the first to call for such a summit, and has since conducted frantic diplomacy to get EU backing for his plans for global reform, diplomats say the Georgian conflict is simply not the focus of Friday's talks.

The summit's keynote result is expected to be the announcement of a timetable for talks on the so-called "New EU-Russia Agreement" -- talks the EU froze in protest at Russia's occupation of Georgia, but which it decided on Monday to restart.

Medvedev is also widely tipped to spend time outlining his own proposals for a "new Euro-Atlantic security architecture," an as-yet vague concept which he first mentioned in June.

Speculation is also growing in Brussels that Sarkozy will push for Russian endorsement of a set of four key principles of financial reformgot stuff to do." "Okay, maybe next time." "Yeah, maybe." "Hi, I'm Olivia Bromsted." "Hi, I'm Olivia." "But you can just call me Olivia." "Hey." "A little something to help you through the phone call." "Thank you." "You put anything else in there?" "I might need more than just coffee." "It's gonna be fine." "I'm sure they loved your new pages." "Mmm, I hope so." "Aren't they already talking about a release date?" "Yeah, they mentioned a Christmas release." "You know, uplifting holiday story." "Daughter return." "Well, she wasn't really returned." "She came back to us." " That's the important thing." " Yeah." "♪" "♪ I feel the floorboard shake ♪" "♪ I watch the sky turn to gray ♪" "♪ I don't see the sun rising ♪"


week until they realized how old I was." "So it was fun while it lasted." "Now, a stowaway, that would be David's dream." "What, to be a 14-year-old stowaway?" "More like a 40-year-old stowaway." "It's true." "Except it'd be Neil Young, not Jim Tyson." "He's cool, actually I just read something about the whole lyrical feud between him and Skynyrd." "It's like totally fiction, apparently." "Right." "Van Zant was answering "Southern Man,"" "but they actually had a lot of respect for each other." "Yeah, that's what it said." "It's interesting, I would have pegged you as more of a classical music kinda guy." "Oh, snap." "No, I'm into classical music myself." "Yeah?" "Yeah, I can dig a little Mozart here and there." "Where'd you go when you gotpoor." " Right." " We can play for pride, though." " I can do that." " All right." " And beers?" " And beers." "I like that even better." "Thank you." "Hey, thanks for inviting me to hang." "Any time, man." "At first, I was like, is this weird?" "Just me and Max?" " 'Cause this is a first for us, right?" " Mm-hmm." "But it's cool." "No, it is cool." "I'm glad." "My dad and I used to play." "Really?" "Yeah." "You think about him a lot?" "Yeah, I do." "Well, how are you doing for real?" "Um, I haven't been sleeping that well." "It's weird, when there's no one there to make sure you get out of bed in the morning." "I mean, I can stay