me in the least if the experiment was initiated
knowing full well it would take decades to complete but they went ahead anyway
'for the craic'.

~~~
mef
"For the craic", the original "for the lulz"
[http://en.wikipedia.org/wiki/Craic](http://en.wikipedia.org/wiki/Craic)

------
elmuchoprez
"Over several decades a number of drips did form in the funnel and fall into
the jar, giving credence to the hypothesis that pitch is indeed viscous."

It sounds like the experiment, as designed, reached a conclusion in far less
time than 69 years. It just took 69 years for someone to think about video
taping it.

~~~
RobAley
Nope, assuming they designed it for scientific rigour. Without observation, it
would be impossible to say, for instance, that some external force (vibration,
wind, mischievous students) hadn't caused the drip to form or fall/break off.
The experiment didn't reach a firm conclusion (to some level of certainty)
without observation.

~~~
nagrom
That's whatto discover that some doofus had left the lens cap on ....

------
matt1
For a bit more background on the history of this experiment and why the
previous drips were missed, check out this recent Radiolab podcast:

[http://joshuafoer.com/radiolab-the-pitch-drop-
experiment/](http://joshuafoer.com/radiolab-the-pitch-drop-experiment/)

~~~
hansjorg
The Radiolab episode was about a similar experiment at the University of
Queensland in Australia.

------
wooptoo
The title is misleading. The experiment did succeed before, it just hasn't
been captured on camera.

~~~
robterrell
Seriously, people did science before there were cameras, right? I think the
drop splatted under the funnel is enough evidence to call it done.

------
defective
I think, after a few missed drops, that I might have added a backup camera.

~~~
rmc
Well it started in the 1940s. There weren't many webcam then, and video
cameras (and tape) were expensive.

~~~
defective
Of course, I understand that. But it lasted so long, through tenured
generation after generation. Even though


When using materials which are susceptible to moisture, it is desirable to know whether those materials have been exposed or are being exposed to a particular level of humidity of the surrounding atmosphere. Humidity indicators are commonly applied to materials and objects to indicate the relative humidity levels in the surrounding air. In desiccants or desiccant containing articles, humidity indicators are known to be applied to the desiccant itself or to the container to indicate the saturation level of the desiccant. Known desiccant containers are made from non-woven fabrics, metal, paper and plastics. When the level of moisture absorbed by the desiccant in the container reaches a specific level of saturation, the desiccant in the container has to be replaced or regenerated. Known containers have a patterned designprotection device (Patent Document 2). In such a protection device, when there are conditions when overcurrent occurs, the bimetal portion of the bimetal switch reaches a high temperature and the contact point thereof separates and opens up, and the current is commutated to the PTC element. As a result, the PTC element effectively interrupts the current which flows in the PTC element due to the PTC element being tripped into a high temperature and high resistance state due to the overcurrent.


You are being proselytized to and that is unconstitutional.

All seconded.

Ed posted about this, but you just know PZ will get a chuckle out of it.

Looooool! At least 2 of the 3 examples are domesticated and very different from the wild forms!

I just learned (via Gregory in Seattle in a comment over at Ed’s) about this vile hate group founded-in part-by Scott Lively and based in Latvia:

Watchmen on the Walls is an international evangelical ministry based in Riga, Latvia. It describes itself as “the international Christian movement that unites Christian leaders, Christian and social organizations and aims to protect Christian morals and values in society.” [1] According to a Southern Poverty Law Center (SPLC) Intelligence report the group’s name derives from the Old Testament book of Nehemiah, in whichbe convinced that the justice system is discriminatory and we know that whites are extremely resistant to such arguments. In another study, we set up survey experiments where we randomly presented white and black respondents with different arguments against the death penalty and three-strikes laws to see what effect the arguments had on their opinions of such policies.

The major finding of the experiments is still shocking. When whites were presented with an argument against the death penalty or three strikes that emphasized the racial bias of the policy, they became more (not less) supportive of capital punishment and three strikes laws. The political lesson of the experiment is clear: confronting racial injustice head-on would be risky for elected officials because most whites do not believe that the justice


my Inner Crank In Overdrive but I’m still cranky about it so I think I will make my annoyance known. [Still (and have been for several years) puzzled why some people so loathe (fear?) the word: Environmentalist?]

* I know, “A day late and (several) dollars short” but hey…” Better late than bankrupt…” Or something….

—- Portia:
Good luck with the carjacking but be careful… A charge of Grand Theft Auto wouldn’t look good on the resume.
— rq:
Loved the ‘Revenge video’.
Haven’t checked out the ‘Yelling at your kids’ link yet. All it took for me (no yelling required) was pointing out to my son that he only calls when he needs money. He hasn’t spoken to me since (*sigh*). He won’t even acknowledge my comments on his FB page (*eyeroll*).
— Howarda while now. What I should really do is just start a blog and run my mouth over there, but I haven’t been able to write much that’s solid. The past few weeks in the US have been super stressful and rage-provoking and fear-provoking, with so much shit hitting so many high-speed fans all over the place. I want to talk about it, but I don’t know where to begin.

And I guess I’ll leave it there, because it’s late and I should be in bed. But thanks!

barnestormer
Welcome in! Tights are to the left (they’re for everyone, btw) and what’s your opinion on Horses? ;)
Hijack away, and don’t worry – before long, someone will be hijacking it away from you again.

Beatrice (and cicely)
Nope, not Red 2, Die Hard 5:


even somewhat acceptable compared to other biases, and there’s not much legally forbidding it.”

Chilly — it is better for someone else to get them than for them to end up in a landfill. I’m not so much worried about dropping my stuff in a landfill, just annoyed that I don’t have an easy alternative to what I was doing.

And kind of meta-pissed that I spend so much mental energy trying to be ethical while e.g. the North Carolina state legislators are going, “fuck it, let’s just make it so no one can vote and throw ourselves a party on our neighbor’s bodies.” Or whatever it is those guys say to each other; I don’t know their lives.

Dalillama, those are good ideas. I wonder if I could get somenot.
I drink coffee—as a medicinal, for the purpose of not inadvertently sleepfaceplanting onto my keyboard, at work.
I doctor it up, some. Hazelnut syrup is a wonderful, wonderful thing.
–barnestormer, hereabouts the Council for the Blind runs a couple of thrift stores; I think there may be one run by/for the local veterans, as well. You might see if there’s anything of that sort in your neck of the woods.

Also: You have not yet stated your opinions on the subjects of peas, Horses, and cheese. Enquiring Minds Need To Know!
–

Alan Rickman was the best thing about the movie Robin Hood: Prince of Thieves.
(yeah, I know, that was a looong time ago)

Ohhhh, yes! Yes, indeed! And the best thing about that Die Hard thing, too, back in the day.
Also, Dogma.
–

I don’t


are apt to flee.

I emerged, above the floor only to find my friends and main compatriots in life weeping and praising dog.

What do you have to lose in sending? *shrug* I don’t know if this is someone who interests you, and if the message will make them not want to respond to you. I don’t know if it will change their mind about anything. In other words, I’m no help.

It isn’t someone I’m interested in; we have a good “match rating” but many of the rest of her answers reveal a lot of internalized kyriarchy and some entitlement and boundary issues. Also some of that sort of coy-combative (coymbative?) demeanor that’s like nails on a chalkboard to me.

(Is this a thing anyone else has noticed? This weird combinationanticipating my story–now STORIES–I have not forgotten. Got so side tracked and took a short nap after work, which turned into sleeping the last five hours)…

Aaaaand now my kitty and I are in standoff…she wants some loving but does not want to jump off the couch and waltz over five feet to me…I want to pet her, but am comfy in my chair…five feet away…who will break first??!!

Sometimes termed “the invisible poor” by demographers, lower-income whites are generally dispersed in suburbs as well as small rural towns, where more than 60 percent of the poor are white.

And:

The risks of poverty also have been increasing in recent decades, particularly among people ages 35-55, coinciding with widening income inequality. … For those ages 45-55, the risk of poverty jumped from


is, barely 2 miles from our subdivision is one of the more active crime areas in Pensacola (according to a police friend). For all that that area has those problems, the criminal activity is almost always confined to that area.
___
I do recall one night, before M died, he came home after work (@11 pm) looking like death warmed over. On the second to last turn before pulling up to our house, a bullet hit his drivers side rear window, shattering it. He was ok, but very shaken. He did file a police report and it turned out rhat some kids were playing with guns that night bc some of their neighbors complained.

So two incidents in ten years, one of which is quite minor. I do not really havethe Snark you could ever want), W-PZM.

(Just woke up and you two were the only ones active for the last few hours here. Reminded me of a radio show.)

I just got in.
Guess what type of AM radio station the driver is listening to?
Hint Words: glory, praise, worship, halleluah, greatness, love, spirit…

Oh my FSM does anyone have industrial strength ear plugs?

(First-worst cab “ride” goes to the accumulated cabbies I rode with in Chicago years ago. Recklesd driving, excessive speeding, creation of their own lanes where none existed, stopping so close to vehicles in front of us that you can read the warnings on rear view mirrors)

Last year in Indiana, a charter school called Christel House had a small problem. Students’ poor algebra test scores had dragged down the school’s


passages in the text, nor do they adopt a jargon. None of them
have memorized the three fundamental propositions, but they can all
explain, each in their own unique way, what those three fundamental
propositions are, and how they relate to the rest of the book. For our
approach, It is not about accuracy or inaccuracy of the text, nor about
accurately quoting the text. It is about the new realizations the
students come to by engaging the text and exploring the subject matter
on their own. The point of these seminars is embodied the process of
understanding, not in the learning of information per se. One can hear
the difference in the way these people talk about Theosophy. They do
not memorize and utter phrases. They do not use technical terminology.
They know the terms, but they alsoto come into the coffee houses with new
slogans and banners. The new slogans were stunning--they communicated
in a few words a long history of oppression and way to bring it to an
end. After a year or so, they still came in uttering the same slogans
and waving the same banners. But, by that time, they had become so used
to uttering them that they had already stopped thinking about what they
really met. They had put themselves in a box, and lost the ability to
see beyond it. They had to reinvent themselves. Then it was W.E.B.
Dubois. Later it became civil rights marches. Personal growth, as well
as social progress continues as long as we are able to see through and
step out of the forms that we create for ourselves.

Look at history. Whose records


into matter could never have been achieved; nor
would it have received its first impulse, had not the bright Spirits
sacrificed their own respective super-ethereal essences to animate the man
of clay, by endowing each of his inner principles with a portion, or rather,
a reflection of that essence.
The Dhyanis of the Seven Heavens (the seven planes of Being) are the
NOUMENOI of the actual and the future Elements, just as the Angels of the
Seven Powers of nature - the grosser effects of which are perceived by us in
what Science is pleased to call the "modes of motion" — the imponderable
forces and what not — are the still higher noumenoi of still higher
Hierarchies. [see S D I 570-5]

It was the "Golden Age" in those days of old, the age when the "gods walked
theit points to the
secret of man's self-consciousness; it is the angle-iron on which hinges his
entire life-cycle; — the history of his evolution and growth.
On a firm grasp of this doctrine depends the correct understanding of
esoteric anthropogenesis. It gives a clue to the vexed question of the
Origin of Evil; and shows how man himself is the separator of the ONE into
various contrasted aspects.
The reader, therefore, will not be surprised if so considerable space is
devoted in each case to an attempt to elucidate this difficult and obscure
subject. A good deal must necessarily be said on its symbological aspect;
because, by so doing, hints are given to the thoughtful student for his own
investigations, and more light can thus be suggested than it is possible to
convey in the technical phrases of a more


Introduction {#S1}
============

Optogenetics has revolutionized neuroscience by making it possible to use heterologously expressed light-gated ion channels and pumps to stimulate or inhibit activity in genetically selected neurons and brain regions and thereby determine their roles in circuit function and behavior^[@R1],[@R2]^. Since the flow of information through neural circuits depends on the strength of synaptic transmission and changes in synaptic strength are critical to neural processing as well as learning and memory, an important further development would be to bring optogenetics to the native pre- and postsynaptic receptors that control synaptic transmission and plasticity.

Of special interest are G-protein coupled receptors (GPCRs), the largest class of membrane signaling proteins, which, because of their importance to disease, are the most explored drug targets in all of biology. GPCRs respond to aof identifying attachment points for optical agonism ([Fig. 1c](#F1){ref-type="fig"}) or antagonism ([Fig. 1d](#F1){ref-type="fig"}).

In order to rationally design light-gated versions of mGluR2, we used Monte Carlo simulations to identify geometrically appropriate cysteine-attachment points for the conjugation of D-MAG-0. First, we built a homology model of mGluR2 in the open, glutamate-bound state using the mGluR1 open, glutamate-bound crystal structure (PDB ID: 1EWK) as a template. We then generated molecular models of D-MAG-0 with geometries of *cis*- and *trans*- azobenzene based on earlier experimentally determined coordinates that were validated computationally^[@R35]^. After manually positioning the glutamate-group of D-MAG-0 in the binding pocket, the Monte-Carlo multiple minimum (MCMM) algorithm^[@R36]^ was used to search the space accessible to D-MAG-0 with single-bond rotations as degrees of freedom. Twenty thousand orientations/structures were generated by MCMM and


recorded postsynaptic currents elicited by brief depolarization steps that elicited single action potentials. Excitatory post-synaptic currents (EPSCs) were detected in some cells ([Fig. 6b](#F6){ref-type="fig"}) and inhibitory post-synaptic currents (IPSCs) were detected in others ([Fig. 6c](#F6){ref-type="fig"}). Activation of LimGluR2 by 380 nm light rapidly and reversibly inhibited both the EPSCs (41±5%, n =8) and IPSCs (36 ± 3%, n =4) ([Fig. 6b and c](#F6){ref-type="fig"}).

In contrast to the potent inhibition by LimGluR2, there was no optical inhibition in either cells transfected with GFP instead of LimGluR2 or cells transfected with LimGluR2 but not labeled with D-MAG-0 ([Fig. 6d](#F6){ref-type="fig"}). Moreover, there was no change in baseline PSC amplitude in labeled and transfected (LimGluR2) cells compared to GFP-transfected or unlabeled cells (223±64 pA; n=12 vs. 262± 68 pA; n=5 vs. 232±91 pA;by decreasing release probability and, thereby, increasing facilitation. This is exactly the mechanism by which native mGluR2 acts presynaptically via inhibition of N and P/Q type voltage-gated calcium channels, as has been observed for native group II mGluRs at the calyx of Held^[@R43]^.. The paired pulse ratio in LimGluR2 positive cells was the same as that in GFP-transfected cells (respectively 1.5±0.1, n=5 vs. 1.4± 0.3, n=4), indicating that expression and labeling of LimGluR2 does not alter basal release.

Finally, we tested the ability of LimGluR2 to produce multiple rounds of inhibition of transmission and recovery and for the inhibition to outlast the activating light pulse due to the bistable nature of the photoswitch. Brief photo-activation produced sustained inhibition of synaptic transmission that persisted in the dark for minutes and


light and purple bars indicate 380 nm light. **(b)** LimGluR2-block photo-antagonism is bistable. A brief flash of 380 nm induces a decrease in glutamate-evoked current which is sustainted in the dark until it is reversed by 500 nm. **(c)** When D-MAG-0 is attached to L300C 380 nm light evokes GIRK1 current on its own. The current remains activated until deactivation is initiated by 500 nm light. No photo-antagonism is seen in the presence of glutamate, indicating that D-MAG-0 is not a partial agonist of mGluR2- L300C. **(d)** LimGluR2-mediated GIRK1 current shows sustained response in the dark following a brief illumination at 380. **(e)** At higher light intensities (\~40 W/mm^2^), 0.5 ms 380 nm pulses can activate and 1 ms 500 nm pulses can fully deactivate LimGluR2. The secondsuppression of opening of a presynaptic voltage-gated calcium channel (VGCC). **(b, c)** Representative autaptic excitatory (b) and inhibitory (c) postsynaptic currents elicited by short (2 ms) depolarizing steps are decreased in amplitude by LimGluR2 activation by 380 nm light (violet traces) compared to deactivation by 500 nm light (green traces. **(d)** Pooled inhibition of EPSCs and IPSCs by optical activation of LimGluR2 compared to controls in which mGluR2 (L300C) was expressed but not labeled with D-MAG-0 and where mGluR2 was not expressed. Values in parentheses denote number of cells tested and error bars show s.e.m. **(e)** Representative single sweeps of paired pulse recordings (50 ms inter-stimulus interval) of EPSCs under 500 nm light (green bar) followed by 380 nm light (violet bar). **(f)** Summary of paired pulse ratio


66 F.3d 566
The FEDERAL DEPOSIT INSURANCE CORPORATION, as Receiver ofCitytrust, Plaintiff-Appellant,v.HILLCREST ASSOCIATES;  Charles F. Stelljas;  Jackie Chan;Thomas J. Scozzofava, Jr.;  Donald A. Mitchell;  Henry H.Moy;  Paul F. Valluzzo;  William Behari, Jr.;  Robert F.Morlock;  Hans C. Otto;  Robin E. Otto;  Adele Stelljas;and People's Bank, Defendants-Appellees,Prudential Securities, Inc. and Merrill Lynch, Pierce,Fenner & Smith, Inc., Garnishees.
No. 1621, Docket 93-6372.
United States Court of Appeals,Second Circuit.
Argued July 22, 1994.Decided Oct. 2, 1995.

Robert E. Pace, Hartford, Connecticut (Cynthia A. Jaworski, Paul R. Aiudi, Kimberly M. Canning;  Corcoran, Mallin & Aresco, P.C., Hartford, Connecticut, of counsel), for Plaintiff-Appellant.
Michael J. Mannion, Baker, Moots & Pellegrini, P.C., New Milford, Connecticut (Guy L. Heinemann, New York City, of counsel), for Defendants-Appellees.
Before:  WINTER, McLAUGHLIN, and JACOBS,is a matter of state statute and does not belong in a judgment."   However, he did not send a copy of the letter to the magistrate judge.

14
Most important, appellees never objected to the recommended judgment in the district court.  Federal Rule of Civil Procedure 72 requires a party objecting to a magistrate judge's recommended ruling to "serve and file specific, written objections to the proposed findings and recommendations" within ten days after being served with a copy of the recommendation.  Fed.R.Civ.P. 72(b);  see also 28 U.S.C. Sec. 636(b)(1).  The rule is "intended to assure that objections to magistrate's orders that are not timely made shall not be considered."   Fed.R.Civ.P. 72 Advisory Committee's note (1991 Amendment).

15
Our rule is that "failure to


message on his Facebook page Friday afternoon regarding the matter.

“My office was made aware of an issue early this morning regarding a constituent from Perrysburg who is overseas and is unable to return. We have reached out to the appropriate governmental agencies to see what can be done to find a resolution,” it read in part.

Yi has since posted on Facebook thanking everyone who has reached out to help him and his family during this difficult time.

“Even though my body is stuck in Korea, my heart is with every single one of you,” he said in the post.STEVEN CURLEY, MD

Comment:

The primary reason that we administered chemotherapy before PVE was because we were concerned about the potential for growth of metastatic disease after PVE. We know that growth factors are released, and we’ve all seen patients who have had actual progression of their disease rapidly after PVE. You have to decide the best sequence, but generally, we administer two to three months of chemotherapy first, perform PVE and proceed with the liver resection four weeks later.

The effects of chemotherapy on the liver have been well described in the recent literature. Regimens containing oxaliplatin can cause a sinusoidal injury to the liver sinusoids, the so-called blue liver, but that does not necessarily cause postoperative complications to the liver. We were cautious using the irinotecan in this patient,


patient with a curative intent so the preference was to use an oxaliplatin-based regimen for neoadjuvant therapy, recognizing that it may confound any preexisting diabetic neuropathy. Several ongoing studies are evaluating the role of diabetes in neuropathy-related oxaliplatin. Is the neuropathy worse? Does it develop after fewer cycles? These things have been suggested, but I’ve seen no definitive proof. We are watching the ongoing studies closely because we’d love to know if we should change the dose of oxaliplatin. Should you change the number of cycles of oxaliplatin, or should we treat these patients even more aggressively by using things like calcium/magnesium and other therapies that reduce the oxaliplatin-induced neuropathy?

Allergic reactions to oxaliplatin

Commentator: STEVEN CURLEY, MD

Comment:

In examination of the data from the NCCTG-N9741 trial, seven percent of patientsit impossible to do
any serious development on a laptop these days.

A 23" Cinema display is the other obvious choice - much sexier, but the specs
are inferior and it costs significantly more.

~~~
reeses
The Dell 24" monitors have quality control issues that the Apple displays
don't seem to have. They're enough less expensive though that it may be worth
it to you to risk the occasional banding or backlight failures.

Or you may just want/need analog inputs that the Apple display can't give you.

~~~
vlad
Series A03 and above of the Dell 24 inch monitor, shipping since September,
have no banding issues. The monitor is absolutely awesome. The best part is
you can probably keep it around for 5 years or more, and it has all the TV
inputs except HDMI that you may need (no tuner, but many


The effect on the basic secretion reached its peak 450 min after drug application whereas the maximal effect on pentagastrin stimulated secretion showed earlier. The effect described was only seen with a dose of the anticholinergic drug of at least 30 mg. A combination of ipratropiumbromide+oxacepam has no effect stronger than ipratropiumbromide alone. On the contrary, it rather seems to have an augementative effect on pentagastrin stimulated gastric secretion that may be compensated completely by ipratropiumbromide. On the basic of these results a direct influence of anticholinergic substances on the parietal cell is discussed.when the desired wave power is smaller than the target control value. Then, the mobile station increases or decreases the up transmission power according to the up control instruction. Transmission of the up control instruction in the transmission power control is performed using a downlink transmitting from the base station to the mobile station.
On the other hand, even in the downlink, by performing transmission power control so that a ratio between the desired wave power and the interference wave power becomes a predetermined amount to realize high channel capacity. In greater detail, in the transmission power control in the downlink, the mobile station measures a reception quality of-the downlink to compare with a target control value for transmitting a down control instruction for reducing transmission power of the


been transmitting to the mobile station before, the down transmission power P maintains the preceding value of the transmission power to the mobile station. On the other hand, if the base station is an auxiliary base station newly starting transmission to the mobile station, the down transmission power P is set at an initial value P0. The primary station and the auxiliary station are notified a frame number to initiate soft hand-over from the control station 71. The initial value P0 may be an arbitrary value falling within a control range of the down transmission power.
At first, when a transmission power balance control message between a plurality of base stations arrives from the control station 71, the base station resets a frame counter I=0 (step S201). The frameminimum power Pmin (steps S211, S212). Then, the process is repeated from the step S202.
In this method, upon timing of initiation of the soft hand-over, since the initial values of the down transmission power of the primary base station and the auxiliary base station are different, there is a difference |P1−P2| between the down transmission power P1 of the primary base station and the down transmission power P2 of the auxiliary base station. On the other hand, upon failure of reception of the down control instruction in one or more base stations, the difference |P1−P2| of these transmission powers P1 and P2 can be increased. However, in a portion of control through steps S203 to S206, namely a portion for increasing and decreasing the down transmission power by


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grievously neglected. It is hoped that His Majesty the Shah—may God assist him by His grace—will turn his attention to this vital and important matter.(Bahá’u’lláh, Tablets of Bahá’u’lláh, p. 89)

Strive as much as possible to become proficient in the science of agriculture for in accordance with the Divine Teachings, the acquisition of sciences and the perfection of arts are considered as acts of worship. If a man engages with all his power in the acquisition of a Science or in the perfection of an art, it is as if he has been worshipping God, in the Churches and Temples. Thus as thou entereth a School of Agriculture and strivest in the acquisition of that science, thou art day and night engaged in acts of worship- acts that areand Amazonic regions, could offer nutritional and health benefits. Several types of the *Passiflora* species are also harvested in these regions; some examples are *Passiflora edulis* var. Flavicarpa, yellow passion fruit (Maracuyá), *Passiflora edulis* var. Sims, purple passion fruit (Gulupa), and *Passiflora ligularis* var. Juss, sweet granadilla (Granadilla), fruits represented in [Figure 1](#molecules-24-04614-f001){ref-type="fig"}.

Despite multiple studies highlighting the uses of tropical fruit flavonoids for the control of free radicals (natural antioxidants) \[[@B7-molecules-24-04614],[@B8-molecules-24-04614]\], or the regulation of fungal and bacterial activities \[[@B9-molecules-24-04614]\], information on anti-inflammatory activity is lacking. Granadilla, Gulupa, and Maracuyá (passion fruits) are promising fruits for further study because of their proven medicinal benefits \[[@B8-molecules-24-04614]\]. The present work aims to identify and quantify polyphenols extracted from *P. edulis* var. Flavicarpa (Maracuyá), *P. edulis* var. Sims (Gulupa), and *P.


ligularis* var. Juss (Granadilla), gathered in the Colombian coffee region, and to evaluate the possible in vitro inhibitory action on inflammation-disrupted intestinal barrier function in Caco-2 cells.

2. Results {#sec2-molecules-24-04614}
==========

2.1. UHPLC-MS Analysis of Passiflora Extracts {#sec2dot1-molecules-24-04614}
---------------------------------------------

Colombian *Passiflora* fruit polyphenols were identified by ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS) in electrospray ionization mode through comparison to reference standards. Subsequently, targeted quantification was applied to characterize the phytochemical profiles of extracts from *P. edulis* var. Flavicarpa (Maracuyá), *P. edulis* var. Sims (Gulupa), and *P. ligularis* var. Juss (Granadilla). A total of 16 compounds were detected that included polyphenols (flavan-3-ols, anthocyanins, phenolic acids), xanthenes, and a triterpenoid were identified in each of the three passiflora samples ([Table 1](#molecules-24-04614-t001){ref-type="table"}). Example chromatograms for reference standards are presented in [Figure A1](#molecules-24-04614-f0A1){ref-type="fig"} ([Appendix A](#app1-molecules-24-04614){ref-type="app"}).

Thethe most abundant polyphenol, as such with *P. ligularis* var. Juss (Granadilla) in the present study. Epigallocatechin, epigallocatechin gallate, and (−)-epicatechin were the other main polyphenols of Colombian passion fruits in the present study. Other less abundant compounds were caffeine, epicatechin, luteolin, apigenin, and quercetin 3-glucoside, which were also reported in other studies of *Passifloras* fruits \[[@B8-molecules-24-04614],[@B10-molecules-24-04614]\].

Colombian passifloras inhibited inflammation-induced intestinal barrier dysfunction in Caco-2 cells. TEER is regarded as a reliable indicator of the normal and functional state of cell membranes analysis and has been applied to a variety of cell types \[[@B11-molecules-24-04614]\]. The integrity of the intestinal barrier is maintained by tight junction (TJ) proteins \[[@B12-molecules-24-04614]\]. Maintenance of these cellular structures are essential for the protection of bacterial translocation and leakage of pro-inflammatory compounds from the


inflammatory routes related to cyclooxygenases (COX) type COX-1 and COX-2, nuclear factor kappa B (NF-κB), and by the increasing tight junction proteins ZO-1 and occludin \[[@B4-molecules-24-04614]\]. In the present study, polyphenols extracted for Colombian *P. edulis* var. Flavicarpa (Maracuyá), *P. edulis* var. Sims (Gulupa), and *P. ligularis* var. Juss (Granadilla) improved TEER values on Caco-2 cells stimulated treated with IC. However, further work is needed to investigate the mechanism(s) of action for improving TEER.

Positive TEER results from *Passiflora* extracts were dose-dependent. Lower doses of 2.5 and 5.0 mg/mL did not improve Caco-2 barrier dysfunction. However, at 10 mg/mL, equivalent to approximately 10--25 mM polyphenols, improved Caco-2 barrier dysfunction. Notably, quercetin alone at 5 mg/mL was not sufficient to inhibit IC-induced TEER dysfunction in Caco-2 cells. Thus, a diversebye, RtcpAppDefined appDefined) {
		this.senderReport = senderReport;
		this.receiverReport = receiverReport;
		this.sdes = sdes;
		this.bye = bye;
		this.appDefined = appDefined;
	}

	public RtcpPacket(RtcpReport report, RtcpSdes sdes, RtcpBye bye) {
		if(report.isSender()) {
			this.senderReport = (RtcpSenderReport) report;
		} else {
			this.receiverReport = (RtcpReceiverReport) report;
		}
		this.sdes = sdes;
		this.bye = bye;
	}

	public RtcpPacket(RtcpReport report, RtcpSdes sdes) {
		this(report, sdes, null);
	}

	public int decode(byte[] rawData, int offSet) {
//		this.size = rawData.length - offSet;
		this.size = 0;
		while (offSet < rawData.length) {
			int type = rawData[offSet + 1] & 0x000000FF;
			switch (type) {
			case RtcpHeader.RTCP_SR:
				packetCount++;
				this.senderReport = new RtcpSenderReport();
				offSet = this.senderReport.decode(rawData, offSet);
				this.size += this.senderReport.length;
				break;
			case RtcpHeader.RTCP_RR:
				packetCount++;
				this.receiverReport = new RtcpReceiverReport();
				offSet = this.receiverReport.decode(rawData, offSet);
				this.size += this.receiverReport.length;
				break;
			case RtcpHeader.RTCP_SDES:
				packetCount++;
				this.sdes = new RtcpSdes();
				offSet = this.sdes.decode(rawData, offSet);
				this.size += this.sdes.length;
				break;
			case RtcpHeader.RTCP_APP:
				packetCount++;
				this.appDefined = new RtcpAppDefined();
				offSet = this.appDefined.decode(rawData, offSet);
				this.size += this.appDefined.length;
				break;
			case RtcpHeader.RTCP_BYE:
				packetCount++;
				this.bye = new RtcpBye();
				offSet = this.bye.decode(rawData, offSet);
				this.size += this.bye.length;
				break;
			default:
				logger.error("Received type = "+type+" RTCP Packet decoding falsed. offSet = "+offSet +". Packet count = "+ packetCount);
				offSet =


of the bonding wires; a first encapsulant formed on the lower surface of the substrate for encapsulating the bonding wires and for filling the opening of the substrate and the aperture of the adhesive tape; a second encapsulant formed on the upper surface of the substrate for encapsulating the chip; and a plurality of solder balls implanted on the lower surface of the substrate at area outside the first encapsulant.
The above package structure provides significant benefits. With no gaps being left between the chip and the substrate through the use of the adhesive tape, the chip can be well held in position on the substrate. During the molding process for fabricating the second encapsulant that encapsulates the chip, the adhesive tape and the first encapsulant respectively formed on    },
        "cases": [
            {
                "expression": "Y_1623",
                "result": true
            }
        ]
    },
    {
        "given": {
            "x": true
        },
        "cases": [


    "expression": "_r_8",
                "result": true
            }
        ]
    },
    {
        "given": {
            "_j": true
        },
        "cases": [
            {
                "expression": "_j",
         ]
    },
    {
        "given": {
            "; !": true
        },
        "cases": [
            {
                "expression": "\"; !\"",
                "result": true
            }
        ]
    },
    {


 {
                "expression": "\"U)\\t\"",
                "result": true
            }
        ]
    },
    {
        "given": {
            "fa0_9": true
        },
        "cases": [
            {
                    "result": true
            }
        ]
    },
    {
        "given": {
            "zs1DC": true
        },
        "cases": [
            {
                "expression": "zs1DC",
                "result": true


Mumbai’s only available real estate.”

Mr Joseph estimates that one village approximately covers five acres of land. With a hundred gaothans in existence, the nearly 500-acre area holds attraction for builders. Other villages such as the ones in Gorai have been able to keep the problems of illegal construction at bay, thanks to better organisation to preserve local culture and way of life. There is less pressure from land sharks. However, two proposed bridges from Gorai and Marve have caused much anguish about the future of the village.

“The people in Gorai are unified. We stay close to each other. If there are any property disputes, we try to settle before going to court. We want development, but not at the cost of our culture,” says Rossi D’Souza, teacher and= l - 2*l + y. Solve -h + 2*h + a = -4, 0 = 2*h - l*a + 8 for h.
-4
Suppose m + 15 = 4*m. Suppose -m*i = y - 37, 5*y + 34 = 2*i + 3. Solve -8 = -d - 2*d - 4*h, -4*h = -i for d.
0
Suppose 0 = 2*o + 2*o - 16. Suppose l + 2*l - 22 = -5*y, -4*y = -3*l + 4. Let k = o - y. Solve 12 = 4*u - 4*g + k*g, -u = -2*g for u.
4
Let c be 2/3 + (-17)/3. Suppose -5*n = 2*j - 2, 5*n - 65 = 4*j + j. Let x = c - j. Solve -g + 0*g + 2*z = -9, 0 = -x*g


-2*k. Solve -u*d + 35 = -5*m, 5*d = -0*d - m + 23 for d.
5
Let c be 14/4 + 3/(-6). Let t be 3*(c + -6 + 2). Let k be ((-2)/(-4))/(t/(-12)). Solve -5 - 4 = -3*b + 3*y, -2*b = k*y + 6 for b.
0
Suppose -42 = 3*i + 3*d, -3*d + 70 = -4*i - 21. Let o = -13 - i. Solve 3*k + o = 5*b + 2*k, -18 = b - 5*k for b.
2
Suppose -2*j = -0*d - 2*d, 0 = -2*d - 5*j + 35. Solve -k - 15 = -d*a, 3*a = 2*k + 2*a + 12 for k.
-5
Suppose 3*j - 14 = -i - 3, -2*j + 9 = i. Solve -j*p + 26 = -2*s + 6*s,Pages

Thursday, August 16, 2012

Topic: Video Game OSTs

You know what I love? Video game music. So it really curls my figurative tail when people insist to me that it doesn't matter, that it's a trivial part of a game. I feel that video game soundtracks are a versatile medium that, like classical music, is capable of conveying a lot of different emotions all in one piece.

That seems like a really bold claim, but hear me out before ripping me a new one. Music by itself is an art medium that transcends a lot of barriers: time, language, age, you name it. Anyone can feel the emotion in an opera, even if they don't speak Italian, for example. The same thing can be said for a video game soundtrack. Even


MVC. Model actions should only handle data-related logic, all the actions should stay within the controller.
Instead, you should be calling the callback from within your controller:
class PostController < ApplicationController
  after_action :notify_users, only: [:create]

  ...

  def notify_users
    @post.mentioned_users.each do |user|
      Notification.create!(recipient: user,
                     actor: @post.user,
                     action: 'mentioned',
                     notifiable: self)
    end
  end

end   of the lower extremity. The only other study to date was conducted by Sarangi et al., who reported an incidence of 30% in their cohort of 30 patients with tibial fractures treated with plaster casts \[[@CR19]\]. In most of these patients, the symptoms resolved within 6 months. Despite a substantial amount of data available regarding the incidence of CRPS, a wide variability in findings persists. This can be attributed to inconsistencies in diagnostic criteria used. For instance, Beerthuizen et al. reported marked differences in the number of patients diagnosed with the IASP, Veldmen and Harden and Bruehl criteria, all of which were utilised prior to the introduction of the Budapest criteria for CRPS \[[@CR20]\]. As such, it is likely that the differences in sensitivities of these criteria are likely


injury, alterations in the central and peripheral nervous systems lead to increased inflammation, and an enhanced responsiveness to pain. These adaptations act as protective mechanisms to promote avoidance of activities that cause further injury. Within the central nervous system (CNS), persistent and intense noxious stimulation of peripheral nociceptive neurons results in central sensitisation. Accordingly, there is alteration in nociceptive processing in the CNS and increased excitability of secondary central nociceptive neurons in the spinal cord. This is mediated by the release of neuropeptides such as substance P, bradykinin and glutamate by peripheral nerves, which sensitise and increase the activity of local peripheral and secondary central nociceptive neurons resulting in increased pain from noxious stimuli (hyperalgesia) and pain in response to non-noxious stimuli (allodynia) \[[@CR26], [@CR32], [@CR33]\]. Research hasa role in treating CRPS, especially in patients in unresponsive to sympathetic blockade. One RCT reported SCS and physiotherapy to be significantly more effective at pain relief compared with physiotherapy on its own at 6 months and 2 years although this effectiveness diminished at long-term follow up of 5 years \[[@CR101]\]. However, the prevalence of complications is high, including lead displacement, pulse-generator pocket revision, pulse-generator failure and infection \[[@CR102], [@CR103]\]. In the majority of patients, SCS is associated with sustained improvements in functional capability, quality of life, depression and pain levels \[[@CR103], [@CR104]\].

Sympathectomy can be performed as an extension of temporary sympathetic blockade in patients who have good but transient relief from sympathetic blockade. This involves severing the sympathetic chains or stellate ganglion using chemicals, radiofrequency or open surgical techniques to


     = 4   // { ssize_t write(int fd, const void *buf, \
	SYS_OPEN                   = 5   // { int open(char *path, int flags, int mode); }
	SYS_CLOSE                  = 6   // { int close(int fd); }
	SYS_WAIT4                  = 7   // { int wait4(int pid, int *status, \
	SYS_LINK                   = 9     = 37  // { int kill(int pid, int signum); }
	SYS_GETPPID                = 39  // { pid_t getppid(void); }
	SYS_DUP                    = 41  // { int dup(u_int fd); }
	SYS_PIPE                   = 42  // { int pipe(void); }
	SYS_GETEGID                = 43  // { gid_t getegid(void); }
	SYS_PROFIL


*tp); }
	SYS_SETGID                 = 181 // { int setgid(gid_t gid); }
	SYS_SETEGID                = 182 // { int setegid(gid_t egid); }
	SYS_SETEUID                = 183 // { int seteuid(uid_t euid); }
	SYS_STAT                   = 188 // { int stat(char *path, struct stat *ub); }
	SYS_FSTAT                  = 189 // { int fstat(int fd, struct stat *sb);= 413 // { ssize_t extattr_get_link( \
	SYS_EXTATTR_DELETE_LINK    = 414 // { int extattr_delete_link( \
	SYS___MAC_EXECVE           = 415 // { int __mac_execve(char *fname, char **argv, \
	SYS_SIGACTION              = 416 // { int sigaction(int sig, \
	SYS_SIGRETURN              = 417 // { int sigreturn( \
	SYS_GETCONTEXT             = 421 // { int getcontext(struct __ucontext *ucp); }
	SYS_SETCONTEXT             = 422 // { int setcontext( \
	SYS_SWAPCONTEXT


   = 436 // { int jail_attach(int jid); }
	SYS_EXTATTR_LIST_FD        = 437 // { ssize_t extattr_list_fd(int fd, \
	SYS_EXTATTR_LIST_FILE      = 438 // { ssize_t extattr_list_file( \
	SYS_EXTATTR_LIST_LINK      = 439 // { ssize_t extattr_list_link( \
	SYS_THR_SUSPEND            = 442 // { int thr_suspend( \
	SYS_THR_WAKE               = 443 // { int thr_wake(long id); }
	SYS_KLDUNLOADF             = 444 // { int kldunloadf(int fileid, int flags); }
	SYS_AUDIT                      = 504 // { int posix_openpt(int flags); }
	SYS_JAIL_GET               = 506 // { int jail_get(struct iovec *iovp, \
	SYS_JAIL_SET               = 507 // { int jail_set(struct iovec *iovp, \
	SYS_JAIL_REMOVE            = 508 // { int jail_remove(int jid); }
	SYS_CLOSEFROM              = 509 // { int closefrom(int lowfd); }
	SYS_LPATHCONF              = 513 // { int lpathconf(char *path, int name); }
	SYS___CAP_RIGHTS_GET


  = 529 // { int rctl_remove_rule(const void *inbufp, \
	SYS_POSIX_FALLOCATE        = 530 // { int posix_fallocate(int fd, \
	SYS_POSIX_FADVISE          = 531 // { int posix_fadvise(int fd, off_t offset, \
	SYS_WAIT6                  = 532 // { int wait6(idtype_t idtype, id_t id, \
	SYS_CAP_RIGHTS_LIMIT       = 533 // { int cap_rights_limit(int fd, \
	SYS_CAP_IOCTLS_LIMIT       = 534 // { int cap_ioctls_limit(int fd, \
	SYS_CAP_IOCTLS_GET         = 535 // { ssize_t cap_ioctls_get(int fd, \
	SYS_CAP_FCNTLS_LIMIT       = 536 // { int cap_fcntls_limit(intthe open water near the southwestern coasts of Korea, which is the southeastern part of the Yellow Sea green-tide patch \[[@pone.0219958.ref010]\]. Thus, the Yellow Sea green tides might possibly lead to the observed relatively high proportions of *U*. *procera* on the Jeju Island coast. However, this hypothesis needs to await future research.

The species diversity and composition in the green-tide *Ulva* communities on Jeju Island might vary in space and time. It has been reported that the most common species changes from *U*. *pertusa* in spring and summer to *U*. *ohnoi* in winter in Mikawa Bay, Japan \[[@pone.0219958.ref050]\]. The study specimens were sampled during a spring-summer season, and therefore further investigations with additional samples collected at a different season (e.g., fall-winter) will allow us to understand seasonal changes in


taxonomical synonyms in the genus *Ulva*.

Our phylogenetic tree-based species delimitation for the genus *Ulva* using two different marker-sets reveals an identical number of species, although tree topologies of some species (e.g., *U*. *ohnoi−U*. *spinulosa*, *U*. *procera−U*. *linza*) are incongruent between the two phylogenies. Furthermore, our algorithmic species delimitation approaches, particularly GMYC supported the number of species groups for *Ulva*. These results highlight the reliability and accuracy of our tree-based criteria for species delimitation of *Ulva*, which has been shown to demonstrate taxonomic complexities, such as several cases of synonyms. Our own morphology-based species identification by eye in the field showed surprisingly high levels of misidentification, emphasizing the importance of molecular-based species determination. It is well known that valid taxonomical characters are difficult to apply to species identification forrecitals and am not wanting to make the API call(s) every time the page loads. I am simply wanting to just store the LAT/LNG so that I can spit out a google map relatively quickly. How can I go about doing this?
The XML will look something like this:
<recitals>
  <recital>
    <location>Mesa, AZ</location>
    <date>2014-1-19 1:31 AM</date>
  </recital>
</recitals>

A:

The easiest way to deal with client-side data is local storage:
window.localStorage['banana'] = {
    type: 'fruit',
    color: 'yellow',
}

window.localStorage['banana'].curvature = 2.71;

It works in almost all browsers. If you need to worry about yet older ones, use amplify. First, add it to your project:
mrt add amplify

Then use it similarly:
amplify.store('banana', {
    type: 'fruit',
    color: 'yellow',
});

amplify.store('banana');


moments early on in the day but the majority of the day was cloudy which culminated in heavy clouds around 5pm and drizzle and rain for around two hours. Max temp reached 33C

The forecast for the next ten days is looking fairly good, a couple of sunny day before the wind starts to pick up again and more clouds should come Samui ways with tropical showers after next weekend .

Yesterday saw a fairly hazy day, the sun was out and about but not always in a blue sky. It stayed dry although there were some threatening afternoon clouds at times and max temp reached 33C

The forecast predicts partially cloudy skies until next weekend when it may turn cloudy with plenty of wind again and the rain picking up.for the next ten days changed again ever so slightly again, still mostly cloudy and still with strong winds, occasionally, like today, with storm like winds but with a lot less rain expected.

Tuesday, 16 August 2016

Koh Samui, Thailand daily
weather update; 16th August, 2016

Today's weather;

It's cloudy and grey with a strong wind blowing over Koh Samui this morning bit it looks like it will stay dry today, despite the cloudy and grey sky. Current temp at 7am is 28C

The always impressive and very photo genetic Meh Guan Ihm at Wat Plai Laem or Wat Suwannaram, around the corner from where we live and one of the most beautiful temples on Koh Samui, in my humble opinion

Yesterday saw a nice and dry day with a bit of everything, except rain.


more rain.

Friday, 12 August 2016

Queen Sirikit's 84th Birthday

Today is Queen Sirikit's 84th Birthday (in Thai สิริกิติ์). She is the queen consort of Bhumibol Adulyadej, King (Rama IX) of Thailand. As the consort of the king who is the world's longest-reigning head of state, she is also the world's longest-serving consort of a monarch.

Sirikit suffered a stroke on 21 July 2012 and has since refrained from public appearances.

Queen Sirikit's 84th Birthday; Queen Sirikit in younger years

This day is also Mother's Day in Thailand and replaces the international Mother's Day around the world.

Queen Sirikit's 84th Birthday; Queen Sirikit's personal standard, which you can see widespread throughout the country in August

Her formal name and title is Somdet Phra Nang Chao Sirikit Phra Borommarachininat Thai: สมเด็จพระนางเจ้าสิริกิติ์ พระบรมราชินีนาถ; "Her Majesty Queen Regent Sirikit".Nutritional risk factors in planned oncologic surgery: what clinical and biological parameters should be routinely used?
Screening for malnutrition is recommended in hospitalized and planned surgical patients. The aim of this study was to analyze the feasibility and routine prognostic value of using the principal recommended nutritional screening and evaluation tools for cancer patients undergoing major surgery. This study is a prospective, 3-month, multicenter observational trial recording weight loss, body mass index, albumin, transthyretin, and PG-SGA. The morbidity rate was assessed on the basis of major complications (MC), whether of an infectious (MIC) or noninfectious (MNIC) nature. Two hundred seventy-five patients were recruited at nine centers. The following percentages were recorded with respect to morbidity: 28.4% MC, 12.7% MIC, and 22.2% MNIC. Univariate analysis revealed a statistical association only


Nutrient intakes and dysglycaemia in populations of West African origin.
Examining the relationship between glucose intolerance and dietary intake in genetically similar populations with different dietary patterns and rates of type 2 diabetes may provide important insights into the role of diet in the pathogenesis of this disease. The objective of the present study was to assess the relationship between dietary variables and dysglycaemia/type 2 diabetes among three populations of African origin. The study design consists of a cross-sectional study of men and women of African descent aged 24-74 years from Cameroon (n 1790), Jamaica (n 857) and Manchester, UK (n 258) who were not known to have diabetes. Each participant had anthropometric measurements and underwent a 2 h 75 g oral glucose tolerance test. Habitual dietary intake wasestimated with quantitative FFQ, developed specifically for each country. The age-adjusted prevalence of undiagnosed type 2 diabetes in Cameroon was low (1·1 %), but it was higher in Jamaica (11·6 %) and the UK (12·6 %). Adjusted generalised linear and latent mixed models used to obtain OR indicated that each 1·0 % increment in energy from protein, total fat and saturated fats significantly increased the odds of type 2 diabetes by 9 (95 % CI 1·02, 1·16) %, 5 (95 % CI, 1·01, 1·08) % and 16 (95 % CI 1·08, 1·25) %, respectively. A 1 % increase in energy from carbohydrates and a 0·1 unit increment in the PUFA:SFA ratio were associated with significantly reduced odds of type 2 diabetes. The results show independent effects of dietary


and regulations as [they] may prescribe, may dispose of mineral materials (including but not limited to common varieties of the following: sand, stone, gravel, pumice, pumicite, cinders, and clay) ... on public lands of *786 the United States."[1] 30 U.S.C. § 601 (emphasis added). Generally, the disposal of these mineral materials occurs "by contract let through competitive bidding." 1-7 American Law of Mining § 7.03[2].
Crucial to the issues in this case, the Common Varieties Act removed certain "common varieties" of minerals from the General Mining Law's definition of "valuable mineral deposit."
No deposit of common varieties of sand, stone, gravel, pumice, pumicite, or cinders and no deposit of petrified wood shall be deemed a valuable mineral deposit within the meaning of the mining laws of the United States sopieces having one dimension of two inches or more.
30 U.S.C. § 611 (emphasis added). Thus, an ordinarily common variety mineral, such as pumice, would remain locatable under the General Mining Law as an "uncommon variety" if it had "some property giving it distinct and special value."
The Department of Agriculture has promulgated regulations, contained in 36 C.F.R. Part 228, that regulate mining operations conducted on National Forest System lands. Subpart C of these regulations governs the "Disposal of Mineral Materials" (i.e. those minerals that fall within the ambit of the Materials Act and the Common Varieties Act). Subpart C's regulations set forth the procedures for disposing of "mineral materials" on National Forest Service lands. See generally 36 C.F.R. §§ 228.47-.67.
Subpart A of these regulations governs the removal of "Locatable


Id. at 90. "To correct this noncompliance," the Notice required Copar to produce "complete records since April of 2002 showing how much pumice was removed each month (total production, not just stonewash laundry industry pumice), and the names and contact information for the purchasers of the pumice." Id. at 91. In accordance with 36 C.F.R. § 228.4(e), the Notice also required Copar to submit a modification to its plan of operations that would essentially restrict the company to mining only the +3/4" pumice it could prove "is being used in the stonewash pumice industry." Id.
Copar filed an administrative appeal challenging the Notice of Noncompliance. The FS affirmed its decision to issue the Notice of Noncompliance on November 21, 2005, and declined to conduct a discretionary review on December6, 2005.
Copar then filed a "Petition for Review and Reversal of Agency Decision" in the United States District Court for the District of New Mexico, seeking "review and a reversal" of the "decision to issue and *791 subsequently affirm the Notice of Noncompliance." Id. at 155. Copar sought a declaration that these agency actions were an unconstitutional taking, in violation of the APA because of their "numerous and significant violations of the principles of reasoned decision making," "in excess of statutory jurisdiction and authority and without observance of procedure," and arbitrary and capricious. Copar also sought to enjoin the enforcement of these agency actions and to enter a stay "prohibiting modifications to El Cajete Plan of Operations until this present case is resolved and for such other relief


Agriculture promulgated these additions, among others, "to end the long standing confusion and misinterpretation of what is a common variety of mineral," and to "bring consistency to classification of mineral materials." 55 Fed.Reg. at 51700. In the Final Rule statement, the Department of Agriculture's response to a public comment illustrated how these regulatory additions classify minerals as common or uncommon variety based on their "actual use."
One respondent raised a concern about the requirement that minerals must be actually used for the purposes stated and indicated that if a "[c]laimant can demonstrate the likelihood of profitability penetrating the market for (uncommon varieties), the deposit will support a valid mining claim despite (present) `common variety' use." In support of this view, the respondent made an analogy to how the discoverywith a ln in /etc/nginx/sites-enabled.
As far as the config:
server {
 root /var/www/mysite/; #or whereever your site files are
 index index.html;

 location /{
  try_files $uri $uri/ =404;
 }
}

You are missing the root portion which tells nginx where the site is located.


 25.9 (10 654)
  Stable/ch pain/asymptom.    44.5 (16 036)       29.7 (1493)         42.7 (17 529)
  NSTEMI                      17.8 (6399)         24.9 (1252)         18.6 (7651)
  STEMI                       6.1 (2206)          9 (454)             6.5 (2660)
  Valv. heartis a class that extends SqlMappedClientDaoSupport.
Given this, I recommend trying this:

Rename ProdMiscDAO to SqlMappedProdMiscDAO.
Extract an interface from SqlMappedProdMiscDAO named ProdMiscDAO (e.g. "class SqlMappedProdMiscDAO implements ProdMiscDAO")
Go through all your code that uses SqlMappedProdMiscDAO and change it to use ProdMiscDAO.
Configure spring to instantiate a SqlMappedProdMiscDAO, wiring it all the classes that need it.

This allows your DAO implementation to still extend SqlMappedClientDaoSupport but also to have an interface. After switching over all classes to use the interface instead of the class, Spring will not have to use cglib to proxy your DAO and the error should go away.

A:

Spring uses proxies, generated at run-time from interfaces, to do things like transactions, aspects, etc.  The proper Spring idiom for objects like DAOs, services, etc. is to start with an interface and create


Indium-copper and indium-silver mediated barbier-grignard-type alkylation reaction of aldehydes using unactivated alkyl halides in water.
An efficient method has been developed for the Barbier-Grignard-type alkylation reaction of aldehydes (including aliphatic version) using unactivated alkyl halides in water in the presence of an In/CuI/I(2) or In/AgI/I(2) system. The reactions proceeded more efficiently in water than in organic solvent. In, CuI or AgI, and I(2) were all essential for the efficient progress of the reactions. A radical-type reaction mechanism was studied and proposed by using 4-pentenal as substrate.and photo were posted, have appeared on their own You Tube videos, printed materials, social media Facebook page, and photographs with Chinese officials. For Tibetans who do not have access to Dolgyal-related websites, CTA deems it their right to know and thus reproduced their materials.

The Central Tibetan Administration stands firm by its belief that freedom of speech is to be exercised responsibly and truthfully. The Tibetan struggle is based on non-violence, a fundamental principle which also applies to how we address internal matters such as the subject of Dolgyal. This sentiment is shared by the Tibetan people as demonstrated by the fact that none of the Dolgyal protesters whose names were posted have been subjected to any attacks within the Tibetan community since the public posting of their


which degrees were obtained in and the majors.

Other Qualifications
Any merits awarded that do not pertain to the job applied could be written down in this section of the CV.

Interests

A CV is used mostly outside of the United States. However, it is not uncommon for US based people to use a CV for job applications such as teaching or when applying for scholarly positions in a doctoral program. A standard CV can be from 3 to 6 pages. But it is recommended that the CV be as short and to the point as possible. If the correct CV format is used to write the CV, keeping it to the point will not be a problem.

Creating a high quality CV can be a challenging task, especially since your career andto apply:

If interested please contact us through NYANetizens on Twitter or ashley.trnr@gmail.com & include any sort of resume or links to past works if you've got them. Don't forget to include your username. We look forward to receiving your application :)

Please use this application template when applying.

FIRST NAME:

USERNAME:

AGE:

GENDER:

ETHNICITY:

LANGUAGE(S):

LOCATION:

TIME ZONE:

What position are you applying for?

Do you have any past work experience (or other) you think qualifies you or could benefit this position?

Please share any links to past work if available:

What kind of availability does your usual weekly schedule afford you?

Anything else you'd like to add?

Reply · Report Post


from {z: 2, k: 10, c: 3}?
2/13
Calculate prob of picking 1 j and 1 o when two letters picked without replacement from jjllqlxjmxjllojojljj.
8/95
Calculate prob of picking 1 u and 1 r when two letters picked without replacement from eeeeeurerueeeueeruee.
6/95
Two letters picked without replacement from gxqxkgqxeqiqxk. What is prob of picking 2 q?
6/91
Three letters picked without replacement from pppf. What is prob of picking 3 p?
1/4
Two letters picked without replacement from kwxhbuxh. What is prob of picking 2 h?
1/28
Two letters picked without replacement from vuuuuluvnununulvnuv. Give prob of picking 2 u.
4/19
What is prob of picking 1 p and 1 a when two letters picked without replacement from {a: 3, k: 1, p: 1}?
3/10
What is prob of picking 1 a, 1 h, and 2 w when four letters picked without"What about now, can you feel it now?" "I've got no idea what you're on about." "The ground doesn't feel like it should." "It's ten years in the future, maybe how this ground feels is how it always feels." "Good thought!" "But no." "It doesn't." "Hear that, drill in start-up mode." "Afterwaves of a recent seismological shift and blue grass." "Please!" "Have you always been this disgusting?" "No, that's recent." "What's in... here?" "Hello!" "Who are you?" "What're you doing here?" "And what're you wearing?" "I dressed for Rio!" "Ministry of Drills, Earth and Science!" "New Ministry, quite big, merged, lot of responsibility on our shoulders, don't like to talk about it." " What're you doing?" " None of your business." "Where are you getting these readings from?"


attack them, they'll fight back." "But!" "There's a peace to be brokered here." " I can help you with that." " This land is ours." "We lived here long before the apes." "Doesn't give you automatic rights to it now, I'm afraid." " Humans won't give up the planet." " So we destroy them." " You underestimate them." " You underestimate us." "One tribe of homo reptilia against 6 billion humans, you've got your work cut out." "We did not initiate combat." "But we can still win." "Tell me where my friend is." "Give us back the people who were taken." "No." "I'm not going let you provoke a war, Alaya." "There'll be no battle here today." "The fire of war is already lit." "A massacre is due.""Not while I'm here." "I'll gladly die for my cause." "What will you sacrifice for yours?" "You're going to what?" "!" "I'm going to go down below the surface, to find the rest of the tribe." "To talk to them." "You're going to negotiate" " with these aliens?" " They're not aliens!" "They're Earth..." "liens!" "Once known as the Silurian race, or, some would argue, Eocenes, or Homo reptilia." "Not monsters, not evil." "Well, only as evil as you are." "The previous owners of the planet, that's all." "Look, from their point of view, you're the invaders." "Your drill was threatening their settlement." "Now, the creature in the crypt." "Her name's Alaya." "She's one of their warriors and she's my best bargaining chip." "I need her alive." "If


she lives, so do Elliot and Mo and Amy." "Because I will find them." "While I'm gone, you four people, in this church, in this corner of planet Earth, you have to be the best of humanity." "What if they come back?" "Shouldn't we be examining this creature, dissecting it, finding its weak points?" "No dissecting!" "No examining!" "We return their hostage, they return ours." "Nobody gets harmed." "We can land this, together." "If you are the best you can be." "You are decent, brilliant people." "Nobody dies today." "Understand?" "No, sorry, no, what're you doing?" "Coming with you, of course!" "What is it, some kind of transport pod?" "Sort of, but you're not... coming with me!" "He's right, you're not." "I have spent all my life excavatingplasma glucose was significantly higher in cattle with LDA (64.7 ± 11.9 vs. 49.1 ± 6.9 mg·min/m*l*), while that for serum insulin was significantly lower in cattle with LDA (0.95 ± 0.39 vs. 2.13 ± 1.36 *µ*U·min/m*l*) than in non-LDA cattle. These findings suggest that beef cattle with LDA have altered glucose metabolism. In Jersey cows with metabolic acidosis, lower insulin levels were also reported with altered glucose metabolism \[[@r2]\]. Likewise, Japanese black cattle with ateliosis were shown to have lower plasma insulin responses during the glucose tolerance test \[[@r9]\]. In addition, insulin resistance and disordered abomasal motility have been reported in Holstein cattle with LDA \[[@r7]\]. Therefore, the disturbed glucose metabolism is likely to be related to the LDA condition.

Both the good and bad prognosis groups increased


mentioned that Morris is well-liked by the veteran playing group, a factor that likely worked in his favour in the recruiting process.

"The good thing for the Sharks is that the playing group really likes Morris," he said.

"He's been coaching them at a camp during the week and they've been very impressed.

"That's quite an achievement given the huge personalities at the Cronulla Sharks camp. They think he's got what it takes."browser so you can see where the problem occurs.

## W804
> User with login: (name) exists but password is incorrect.
> User with login: (name) exists, but (parameter) is not (expected value) which was specified.
> User with login: (name) exists, but role (name) is not in the list of applied roles: (value).

Check your `behat.yml` for typos.

## W806
> The text "(value)" was not found in the toolbar.

Has the user authenticated? Can the user see the WordPress Toolbar?

## W807
> Toolbar shows authenticated user is "(value)", not "(expected value)".

Has the user authenticated? Can the user see the WordPress Toolbar?
Check your `behat.yml` for typos.

## W808
> Content editor is in "(value)" mode. Expected "(another mode)".

In WordPress' Post Editor, are both TinyMCE and Rich Text views available for the `post_content` field?

## W809
> Metabox "(name)" was found on the page,


having been supplied with the documents at issue, nor with any more particularized log, there is no way for this court to ascertain whether the assertions of harm apply to all or to some. Improperly applying a presumption of secrecy, the court's blanket protective order applies to all.
Although granting of a motion for leave to file a petition for writ of mandamus and issuing a stay to permit time for a response can frequently be helpful in evaluating the merits of the right to relief, nothing is served in this case by delay where our procedural rules clearly indicate an available remedy. I would overrule Relator's motion with a notation citing the applicable appellate provision of Rule 76a, allowing Relator to pursue in a timely manner any legitimate/**
 * This file has no copyright assigned and is placed in the Public Domain.
 * This file is part of the mingw-w64 runtime package.
 * No warranty is given; refer to the file DISCLAIMER.PD within this package.
 */
#define FTPWPP_ERROR_FIRST __MSABI_LONG(0x40042300)
#define FTPWPP_ERROR_INETOPEN_FAILED __MSABI_LONG(0xC0042301)
#define FTPWPP_ERROR_AUTHENTICATION_FAILED __MSABI_LONG(0xC0042302)
#define FTPWPP_ERROR_LAST __MSABI_LONG(0x400423FF)


(meaning ‘Problem Exists Between Chair And Keyboard’). “No sign anything is actually broken here. Looks like just a troll. Status: INVALID or WORKSFORME?”

And so the firestorm began.

‘Spamming’ the block chain

Luke_Jr is Luke Dashjr, a developer who runs his own mining pool and has stood for election to the Bitcoin Foundation board. He also maintains software packages for Gentoo and contributes to the bitcoin core development team.

Dashjr had written a patch for Gentoo’s version of bitcoind that specifically blacklisted bitcoin addresses used by several sites, the majority of which were gambling sites: SatoshiDice, BitcoinDice, Satoshibones, and Luckybit. It also blocked addresses operated by Mastercoin, and Counterparty. And the address discussed here as a spam attack on the network was also in the blacklist.

A code listing for the patch can2013 (which was after the December 19, 2013 deadline set by Justice Bransten), but that plaintiff "wanted to keep the makeup air fan independent of the exhaust fan," so work was not performed by FCA to interlock the makeup air fan with the other exhaust system components. Defendant's expert also testified that, as of February 19, 2016, the makeup air fan was still not interlocked with the other components, in violation of the Code.
Despite its earlier ruling that Justice Bransten's orders were the law of the case and that the only issue at trial was whether the Code violation had been cured, the trial court issued an order after trial, entered June 1, 2016, that found that defendant had failed to establish any violation of the Code, determined


made to not fly this test article and the team is focused on the Mk3 builds, which are designed for orbit. — SpaceX

Starship is the second stage of a reusable two-stage vehicle that will take cargo and people to Earth orbit and elsewhere in the solar system including the surface of the Moon and Mars. It is both a rocket stage and crew quarters. The first stage, Super Heavy (formerly Big Falcon Rocket or BFR), is just propellant.

The company completed two successful hover tests of a small “hopper” in July and August to demonstrate that small vehicle could lift off, fly to a certain altitude, move horizontally, then land close its launch pad. The tests generated a lot of excitement in the space community as did an updatewas the coronation?" "It was a cold, meagre and uncomfortable thing." "And your absence was noted, Sir Thomas." "How is Her Majesty bearing up under all of this?" "I am no longer allowed to see her." "And it is increasingly difficult for us to exchange letters." "I'm gonna try and see her." "That would be so dangerous." "Even to speak a word in her praise is to risk imprisonment." "Nevertheless." "You know, I have been thinking about the past when I believed the king to be the most enlightened and promising prince in Christendom." "I was sure his reign would be a golden age." "I had such high hopes." "Bishop Fisher has been placed under house arrest." "You should beware yourself, Eustace." "You will all be honourable, discreet,


behalf?" "That was exquisite." "How do you like life at court, Mark?" "I feel...." "I feel twice fortunate, my lord." "Twice?" "Once for being allowed to come here and twice for the patronage of your family." "We like to patronize artists, men of talent." "The painter Holbein stayed with us and my sister supports many musicians and choirs." "Yes, well, your sister is quite a talented musician herself." "As well as a very beautiful young woman." "Even though...." ""Even though"?" "Not as beautiful as her brother." "What's this?" "The final decision of the curia in Rome." "They have found for Catherine." "They declare my new marriage invalid and any children produced from it, illegitimate." "The pope threatens to excommunicate me if I do not return to Catherine." "He'ssome complete roof structure failure on small residences. Major erosion of beach areas. Terrain may be flooded well inland.
- Examples: Hugo 1989 and Donna 1960

156 and up

Hurricane
Category 5

Complete roof failure on many residences and industrial buildings. Some complete building failures with small utility buildings blown over or away. Flooding causes major damage to lower floors of all structures near the shoreline. Massive evacuation of residential areas may be required.
- Examples: Andrew(FL) 1992, Camille 1969 and Labor Day 1935

Proud member of the National Weather Service "SkyWarn" program

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train yourself not to think about it. It will just slow you down. I was once told by someone that it's 20% training and 80% mental. I do believe that."

After getting "involved with some stuff" he said shouldn't have, Stolzfus says he was introduced to running by his brother-in-law.

The future is uncertain for Stolzfus, but he said he is interested in running an ultramarathon and attempting to qualify for the Boston Marathon. Stolzfus finished just a minute short of a Boston Marathon qualifying time for his age group.

Contributing: The Associated PressScotland Group's executive committee, RBS's nine-member executive leadership team. In October 2013, she retired as chairman and CEO of RBS Citizens Financial Group and RBS Americas.

CIT Group
Alemany became the CEO of CIT Group in April 2016 and became chairwoman in May 2016. Upon taking over as CEO, Alemany began simplifying the company by focusing on lending and deposit-gathering. CIT has since divested from its riskier, non-core businesses, which required the company to exit its international presence.

Alemany has also been credited with increasing the number of women in CIT's senior ranks. There were only two women on CIT's executive team when Alemany took over as Chairwoman and CEO of CIT. As of September 2018, there were five women on the 15-member panel, in roles such as chief technology and


Link”; and German Patent Number 3,723,832 entitles “Printed Circuit With An Integrated Fuse.” Other “non-serviceable fuses within the meaning of this disclosure include fuses that would otherwise be replaceable but for their physical location in the system (i.e., fuses that are positioned in inaccessible locations).
While serviceable fuses are conveniently replaceable, they can represent a significant cost to the manufacturer of the original product in comparison to the use non-serviceable fuses. A serviceable fuse is more costly to manufacture than a non-serviceable fuse. Further, a serviceable fuse must be physically installed, either manually or by machine, in the terminals in the electrical distribution center assembly, thereby adding additional steps and costs to the manufacturing process. Even where the installation is accomplished automatically, various steps in the automated process, suchas manual loading of the supply tubes for the automatic insertion equipment, must still be performed manually. On the other hand, non-serviceable fuses are less costly to manufacture and they do not require any special handling or fixturing. However, when such a non-serviceable fuse blows, it is not possible for a mechanic or consumer to rapidly and inexpensively replace the fuse alone. Instead, the entire device or a circuit board (on which the non-serviceable fuse resides) must be replaced when a non-serviceable fuse blows. Thus, it is significantly more costly to replace a non-serviceable fuse (i.e., replace an entire circuit board) than to replace a serviceable fuse.
As a result, a dilemma exists in designing fuses into electrical systems. It may be advantageous to a manufacturer to choose a


on CNS by Cilostazol have tried to explore about amelioration of neuronal damage, neuroprotection, improvement of cognitive function, prevention of cerebral ischemia through various mechanisms in preclinical studies.\[[@ref8]--[@ref10]\] Phosphodiesterase (PDE) inhibitors present a potentially powerful means to manipulate second messengers involved in learning, memory, and mood.\[[@ref11]--[@ref14]\] PDE inhibitors are currently being investigated as possible memory enhancers, antidementia drugs, antidepressants, and antipsychotic agents due to location of PDEs in brain at discrete sites.\[[@ref15]--[@ref19]\] Cilostazol served as an alternative to milnacipran for the treatment of patients with post stroke depression as it leads to decrease in Hamilton rating scale for depression (HAM-D) after switching from milnacipran to cilostazol (100mg/day).\[[@ref20]\] Thus, cilostazol is being evaluated for antidepressant and anxiolytic activity in mice.

MATERIALS AND METHODS {#sec1-2}
=====================

Animals and environment {#sec2-1}
-----------------------

Experiments were performed onintraperitoneal administration of cilostazol (20 mg/kg) there was extremely significant decrease in immobility time (70.66±2.27; *P*\<0.001) as compared to control (123.33±9.44). Animals treated with fluoxetine (20 mg/kg), showed significant decrease in the immobility time (32±3.12; *P*\<0.001) when compared to control (123.33±9.44). Cilostazol also showed significant decrease in immobility time (63±5.22; *P*\<0.001) and thus marked antidepressant activity when compared to Fluoxetine (32±3.12).

![Effects of Cilostazol and fluoxetine on duration of immobility in the FST. Note: Results are expressed as Mean±S.E.M (n = 6). \*\**P*\<0.001 as compared to control group. ††*P*\<0.001 as compared to fluoxetine](IJPsyM-34-124-g004){#F2}

Marble burying model {#sec2-8}
--------------------

In this test \[[Figure 3](#F3){ref-type="fig"}\], a significant decrease in the number of marbles buried (8.33±0.42; *P*\<0.001) was observed with intraperitoneal administration of cilostazol (20 mg/kg) as compared to control (16.33±1.33). Similarly, animals treated with


Q:

How to add quote icon in Bootstrap glyphicons?

I guess the titles tells it all.  The quote icon is absent in glyphicon icon set in bootstrap 3 which I'm using.
I know that I can use a separate image but it would mean an extra request being made and also the image will not be vectorial. so I'm wondering maybe there is a more elegant way to do so?

A:

blockquote {
  background: #f9f9f9;
  border-left: 10px solid #ccc;
  margin: 1.5em 10px;
  padding: 0.5em 10px;
  quotes: "\201C""\201D""\2018""\2019";
}

blockquote:before {
  color: #ccc;
  content: open-quote;
  font-size: 4em;
  line-height: 0.1em;
  margin-right: 0.25em;
  vertical-align: -0.4em;
}

I'm quoted

A:

Try using Font-Awesome http://fortawesome.github.io/Font-Awesome/icons/ it has qoutes.
Download and implement it in your project, when your done implementing it you can useComparison of histochemical properties of different pig breeds.
The study involved 158 pigs: 51 Hampshire (H), 54 Landrace (L) and 53 Yorkshire (Y). The aim of the study was to compare muscle histochemical properties of M. longissimus dorsi and adductor between muscles from pigs of purebred Hampshire, Landrace and Yorkshire lineages. The following histochemical properties were determined: 1) the percentage of type I, IIA and IIB fibers in number (calculated on the basis of the number of different fiber types) and area (calculated on the basis of the area of different fiber types) as analyzed with the myosin ATPase method using an acid preincubation solution of pH 4.6; 2) the cross sectional area of each fiber type; 3) the percentage of oxidative fibers on the basis of the NADH-TR


speaking, this problem is described as a game of guessing a realization of a discrete random variable $X$ by asking questions of the form “Is $X$ equal to $x$ ?”. Let $G(x)$ be the number of guesses required by a guessing strategy when $X = x$. Then, one of the interesting questions is “What is the fundamental limit of the $\rho$-th moment[^1] of the number of guesses $\mathbb{E}[G(X)^\rho]$?”. Several previous studies for this question are summarized as follows:[^2]

-   Arikan [@Arikanlossless] derived the [*non-asymptotic*]{} achievability and converse bounds of the $\rho$-th moment of the number of guesses $\mathbb{E}[G(X)^\rho]$ by using the [*Rényi entropy*]{}. He also investigated the problem of guessing with side information and characterized the [*non-asymptotic*]{} achievability and converse bounds of the $\rho$-th moment of theinformation) by using the [*rate-distortion function and relative entropy*]{} (resp. the [*conditional rate-distortion function and relative entropy*]{}) under a stationary memoryless source when blocklength goes to infinity.

The above previous studies raise the following question, which motivated us to carry out this research.

-   Regarding the guessing subject to distortion, is it possible to derive [*non-asymptotic*]{} achievability and converse bounds by using a quantity related to the [*Rényi entropy*]{}?

This paper gives a positive answer to the question ($\clubsuit$).

Contributions
-------------

For the problem of guessing subject to distortion, our first contribution is to prove non-asymptotic achievability and converse bounds of the $\rho$-th moment of the number of guesses without side information (resp. with side information) by using a quantity based on the Rényi entropy (resp. the Arimoto-Rényi conditional entropy). To derive the results, we


\downarrow 0$. Our result in the case without errors coincides with the result of Arikan and Merhav [@Arikan]. Further, our result in the case of allowing errors indicates the benefit of allowing a positive error probability.

Organization of the Paper
-------------------------

Section \[setup\] describes the problem setup. Section \[PreviousStudy\] reviews the related previous results in [@Arikan]. Section \[Main\] shows our results. Proofs of one-shot achievability and converse bounds are in Sec. \[Proof\]. Finally, in Sec. \[Extension\], we introduce an error probability and show our results in the case allowing errors.

Problem Setup {#setup}
=============

This section reviews the setup of the problem of guessing subject to distortion described in [@Arikan]. Let ${\cal X}$ be a finite set called a source alphabet and $\hat{{\cal X}}$ be a finite set called a reproduction alphabet. Let $X$ be a[@Saito18], $(c)$ follows from the definition of the Rényi entropy and the variable-length lossy source code $(f, g)$ in Appendix \[code\], and $(d)$ follows from (\[appendfg\]) in Appendix \[code\].

Proof of Converse Bound (\[OneShotC1\]) {#ProofOneShotConverse}
---------------------------------------

Let ${\cal G}$ be a $D$-admissible guessing strategy with guessing function $G (\cdot)$ and let $p_i$ be $$\begin{aligned}
p_i := \sum_{x \in {\cal X}: G(x) = i} P_{X}(x).\end{aligned}$$ Then, the $\rho$-th moment of the number of guesses of this guessing strategy is calculated as $$\begin{aligned}
\frac{1}{\rho} \log \mathbb{E}[G(X)^\rho ]
= \frac{1}{\rho} \log \sum_{i=1}^{t} p_{i} i^\rho \label{ConvLower}\end{aligned}$$ for some $t \in \mathbb{N}$. Next, let $q_i ~ (i=1, \ldots, t)$ be a rearrange version of $p_i ~ (i=1, \ldots, t)$ in decreasing order of its value, i.e., $q_i$ satisfies $q_1 \geq q_2 \geq \ldots \geq q_t$ and $q_j


(x) P_{\hat{X} |X} (\hat{x} | x) d(x, \hat{x}) \leq D$. Regarding the definition of $R(D, Q_{XY})$, see (80) in [@Arikan].

[^4]: More precisely, (\[HR\]) is a special version of (46) in [@Saito18].

[^5]: Note that the error probability considered in this section is different from the error considered in [@Kuzuoka].

[^6]: Here, a guessing strategy is not necessarily a $D$-admissible guessing strategy.
Q:

How does Haskell determine what kind of boolean a randomly generated number is?

Consider the following two groups of code:
random (mkStdGen 1) :: (Int, StdGen)
-- returns (7918028818325808681,545291967 2103410263)
random (mkStdGen 1) :: (Bool, StdGen)
-- returns (True,80028 40692)

random (mkStdGen 949488) :: (Int, StdGen)
-- returns (9159618695640234475,587416689 2103410263)
random (mkStdGen 949488) :: (Bool, StdGen)
-- returns (False,1485632275 40692)

Why does 7918028818325808681 translate to True but 9159618695640234475 translates to False?

A:

The Instance Bool shares the implementation with Instance Int, but the code that is shared is the one for randomR, which takes a range. We can verify this using QuickCheck:
Prelude> import Test.QuickCheck
Prelude Test.QuickCheck> import System.Random
Prelude Test.QuickCheck System.Random> :{
Prelude Test.QuickCheck System.Random| prop seed = let
Prelude Test.QuickCheck System.Random|   gen = mkStdGen seed
Prelude Test.QuickCheck System.Random|   b = fst (random gen)
Prelude Test.QuickCheck System.Random|


not autonomous. It is structured outside themselves. Therefore, if a believer thinks God has asked him to kill his wife or his child, then he should do that, just as Abraham would have.

There are many examples of how religion and belief in God have no bearing on morality. In Japan, for example, over 30 percent of the citizens identify as atheists. Yet after a 9.0 magnitude earthquake in 2011, the world was awed by the lack of looting, by how orderly and calm the citizens remained, sharing their food, water and homes with others less fortunate. It’s clear that morality doesn’t come from religion. It doesn’t come from a distant God who doesn’t communicate with us. It’s a social construct that we learn first and best from ourIn 2009 the group purchased the Spanish debt collection service provider Acción de Cobro from Banco Pastor. It entered the Croatian market by establishing EOS Matrix d.o.o. Thanks to a majority shareholding in WCF Finetrading AG, the group expanded its activities in commodity prefinancing, a business segment that the company then relinquished in 2017.

A location in Ukraine was established in 2010. In the same year, the company strengthened its presence in the USA through the acquisition of True North AR. This was followed in 2011 by the purchase of a majority stake in Hoepers Recuperadora de Crédito S.A, a debt collection service provider in Brazil. Since April 2011 the company has also been offering its services in France following its takeover of debt collection company Credirec. The group


            }

                $ParamOptions2 = New-Object System.Management.Automation.ValidateSetAttribute -ArgumentList $arguments2

                $attributeCollection2 = new-object -Type System.Collections.ObjectModel.Collection[System.Attribute]
                $attributeCollection2.Add($attributes2)
                $attributeCollection2.Add($ParamOptions2)

                $dynParam2 = new-object -Type System.Management.Automation.RuntimeDefinedParameter("Quota", [String], $attributeCollection2)

                $paramDictionary.Add("Quota", $dynParam2)
   hypoxic cells to radiation therapy, since then researchers have been attempting to eliminate tumor hypoxia, but there is no effective approach [@pone.0034646-Brown3].

Since one of the major factors causing hypoxia is the inadequate vascular supply of tumor, more recent attempts to improve tumor radiation response have involved specifically targeting the tumor blood supply. However, this strategy also seems counterintuitive: it is a widely held belief that antiangiogenic therapy eradicates tumor vasculature, thus depriving the tumor of oxygen and nutrients. However, preclinical models have shown that antiangiogenic therapy may transiently "normalize" the tumor vasculature to make it more efficient for oxygen delivery, thereby providing a window of opportunity for enhanced sensitivity to radiation treatment [@pone.0034646-Jain1], [@pone.0034646-Jain2], [@pone.0034646-Winkler1], [@pone.0034646-Fukumura1], [@pone.0034646-Dings1], [@pone.0034646-Jain3], [@pone.0034646-McGee1], [@pone.0034646-Chae1], [@pone.0034646-Hedlund1], [@pone.0034646-Cerniglia1]. Since there are no guidelines for


the effects of endostar combined with radiotherapy have been unclear.

We hypothesized that endostar could normalize the morphology and function of NPC vasculature for a period of time, leading to transient improvement in tumor oxygenation and response to radiation therapy. Here, we investigated transient changes in morphology of tumor vasculature and hypoxic tumor fraction in response to endostar in human NPC in mice. We evaluated the effects of endostar combined with radiation therapy in human NPC and also explored potential mechanisms.

Materials and Methods {#s2}
=====================

Ethics statement {#s2a}
----------------

All animal work was conducted according to relevant national and international guidelines. The animal use protocol has been reviewed and approved by the institutional animal care and use committee of Sun Yat-Sen University (IACUC SYSU, NO.20100703004). For details please refer to subsection entitled Cellratio of green (Pimonidazole) to blue (DAPI) channel mean fluorescence intensity.

Immunohistochemistry for angiogenic factors {#s2h}
-------------------------------------------

CNE-2 tumor-bearing mice were sacrificed 5 days after endostar treatment. Tumor tissues from each group were formalin-fixed and embedded in paraffin, then sectioned at 5 µm thickness and stained with H&E according to standard immunohistochemical procedures. The sections were used to detect the expression of vascular endothelial growth factor (VEGF), pigment epithelium-derived factor (PEDF), matrix metalloproteinase-2 (MMP-2), MMP-9, and MMP-14. The samples were incubated with rabbit polyclonal VEGF (1∶200; Abcam), rabbit polyclonal PEDF (1∶200; Chemicon), rabbit anti-mouse polyclonal MMP-2 (1∶50; Santa Cruz), rabbit polyclonal MMP-9 (1∶50; Labvision), rabbit polyclonal MMP-14 (1∶50; Thermo). Primary antibody diluent was used as a negative control in all IHC studies. The immunoreactivity positive cells from each of the differently


NPC xenografts. Our data showed, in agreement with the previous studies, that tumor hypoxic fraction decreased on day 5 to day 7 in CNE-2 xenografts and day 3 to day 5 in 5--8F xenografts after endosar treatment ([Fig. 4](#pone-0034646-g004){ref-type="fig"}), which suggested that intratumoral hypoxia was improved during the endostar treatment.

Mounting evidence supports the view that alleviation of tumor hypoxia and improved vascular delivery may enhance the cytotoxic effects of chemotherapeutics and ionizing radiation [@pone.0034646-Jain2]. Our data showed that the radiation response was the greatest when radiation was administered on the day 5 in CNE-2 xenografts and day 3 in 5--8F xenografts after endostar treatment, whereas the other time windows showed no benefits ([Fig. 5](#pone-0034646-g005){ref-type="fig"}), which was consistent with the previous studies. Bevacizumab, an anti-VEGFR antibody, has been demonstratedthis.
                // Also, if that text includes trivia, then we can't do anything.
                var token = SyntaxFactory.ParseToken(text);
                if (token.Span.Length == span.Length)
                {
                    // var, dynamic, and unmanaged are not contextual keywords.  They are always identifiers


with ThArNe lamps. A spectrophotometric standard star was observed directly before the target observation in order to perform a flux calibration.

The reduction of the FEROS data, including flatfield correction, bias and background subtraction, order tracing, wavelength and flux calibration, was performed manually with the FEROS Data Reduction Software based on ESO-MIDAS.

The log of our spectroscopic observations is listed in Table\[tab:log\].

Photometry {#sec:phot}
----------

To detect possible photometric variability of MN18, we determined its $B, V$ and $I_{\rm c}$ magnitudes on CCD frames obtained with the 76-cm telescope of the SAAO during our five observing runs in 2009–2014. We used an SBIG ST-10XME CCD camera equipped with $BVI_{\rm c}$ filters of the Kron-Cousins system (see e.g. Berdnikov et al. 2012). We also calibrated the 1.9-m telescope spectrum and synthesized its $V$ magnitudeof the equatorial ring in the [*Spitzer*]{} and SHS images (see Fig.\[fig:neb-2\]). This panel also shows that the line intensities peak at $\approx$8.5 arcsec from the star, which reflects the toroidal topology of the nebula.

The lower panel of Fig.\[fig:Lines\] shows that the \[\] $\lambda$6584/H$\alpha$ line ratio increases with distance from MN18 and peaks at the edge of the nebula. Using the prescription by Dopita (1973), one finds that \[\]/H$\alpha$ is proportional to $n_{\rm e} ^{-1} T_{\rm
e} ^{1/2} \exp(-21\,855/T_{\rm e})$, where $n_{\rm e}$ and $T_{\rm
e}$ are the electron number density and temperature, respectively. Thus, the behaviour of \[\] $\lambda$6584/H$\alpha$ could be explained (at least in part) by the temperature increase of the photoionized gas towards the outer edge of the nebula (caused by the hardening of the ionizing radiation


merger of the binary components can enhance the surface N abundance of the mass gainer star or the merger product, respectively, by a factor of several even in the absence of rotational mixing[^9] (Langer 2012; Glebbeek et al., 2013). As follows from the studies by Mason et al. (2009), Sana & Evans (2011) and Chini et al. (2012), the majority of massive stars are members of close binary systems. Furthermore, according to Sana et al. (2012), about 70 per cent of all massive stars are strongly affected by binary interaction during their lifetimes through the mass transfer, common envelope evolution or merger, and for more than half of them the interaction takes place already during the main sequence phase (see also de Mink et al. 2014). All of& van der Hucht 2005; Smith et al. 2011), and focusing of the primary’s wind towards the orbital plane by the gravitational field of the companion star (e.g. Fabian & Hansen 1979; Mastrodemos & Morris 1999). Similarly, the binary mergers can not only produce the rapidly rotating stars, but also result in mass ejection ($\sim$10 per cent of the binary mass; Suzuki et al. 2007), which is mainly concentrated in the binary’s equatorial plane. Moreover, the instant mass loss during the merger event may bring the merger product to the Eddington limit, which in turn would result in a copious mass loss by stellar wind.

If the origin of the equatorial ring around MN18 is indeed caused by the equatorial mass loss from either a nearly critically rotating mass


1995). The masses of the equatorial rings range from $\approx$0.1 to $1 \, {\rm\,M_\odot}$ with the lowest mass belonging to the ring around Sk$-$69$\degr$202. This ring, however, might be more massive if we see only its inner-faced ionized part (e.g. Plait et al. 1995; cf. Fransson et al. 2015).

Finally, Table\[tab:bip\] gives also the nitrogen abundances (by number) of the equatorial rings. In the Sk$-$69$\degr$202 ring the N abundance is a factor of 20 greater than the LMC in general (7.14 dex; Russell & Dopita 1992), which is consistent with the fact that the material of this ring was ejected during the final stage of the evolution of Sk$-$69$\degr$202. The Sher25 ring is also greatly enriched with nitrogen as compared to the background [H[ii]{} ]{}region NGC3603 and the Sun,
106 Cal.App.3d 294 (1980)
165 Cal. Rptr. 69
FRANCES D. SHAIN, Plaintiff and Appellant,
v.
CITY OF ALBANY, Defendant and Respondent.
Docket No. 44715.
Court of Appeals of California, First District, Division One.
May 29, 1980.
*296 COUNSEL
Barbagelata, Carmazzi, Arnold & Del Bino and Robert D. Barbagelata for Plaintiff and Appellant.
Crosby, Heafey, Roach & May, E. Melville McKinney, Peter W. Davis and Clinton A. Johnson for Defendant and Respondent.
OPINION
NEWSOM, J.
The present appeal is from an order striking plaintiff's cost bill and awarding costs to defendant and respondent.
The underlying action was one in tort, tried before a jury. Prior to the commencement of trial, respondent filed an offer of compromise in the amount of $100,000 with each party "to bear its own costs." Plaintiff (hereinafter appellant), rejected the offer, proceeded to trial and obtained a verdict in


a bike and incorporates 'vibration stimulation’ as you ride.

10 per cent of adults now cycle at least once a week, now the Happy Ride seat will no doubt encourage a few more to embrace two wheels...

Manufactured with a padded lining and black nylon fabric outer surface the cover, which houses a powerful vibrator, is designed to fit all seats.

The gadget comes with an attached control pocket to raise or lower the vibration rate.

The vibration can be turned on and off using the control pad which then tucks into a pocket in the seat cover allowing you to peddle away uninhibited.

The vibration is controlled by a control panel that then tucks neatly into a pocket at the back of the seat

Launched by an adult toy retailer, the Happy Rideafter him) and in 1894 entered Trinity College, Cambridge, working under the physiologist John Langley. For a few months in 1903 he also studied under Paul Ehrlich in Frankfurt, Germany. Also in 1903, Dale assisted Ernest Starling and William Bayliss in the vivisection of a dog, by removing the dog's pancreas and then killing the dog with a knife, which ultimately led to the events of the Brown Dog affair. Dale received his Doctor of Medicine degree from Cambridge in 1909.

Career and research
While working at the University College London, he met and became friends with Otto Loewi.  Dale became the Director of the Department of Biochemistry and Pharmacology at the National Institute for Medical Research in London in 1914. He became a Fullerian Professor of Chemistry at


premier Dalton McGuinty’s — and he’s convinced the personal touch is his only path to victory.

Of course, a party’s platform — and especially its leader — can make or break almost any local candidate. This may be the case in Ottawa West-Nepean where about 1,000 votes separated Liberal incumbent Bob Chiarelli and PC candidate Randall Denley in 2011. Chiarelli’s been a politician in this town forever, while Denley used to write this column, so both candidates are well known. What will make the difference? Policies? Leaders? Ground games?

Obviously a mix of all three, but local candidates only control that third factor. Speaking at Denley’s launch, MacLeod told the crowd that Ottawa West-Nepean is one of the ridings the Conservatives have to take if they want to form theArchives

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