conclusion, we observed impaired MFP task performance in patients with AD when compared to that of healthy controls. Performance was associated with GMV reductions in several frontal, temporal, and subcortical regions. These results suggest that MFP performance is a manifestation of the degeneration of auditory-related brain regions in AD. Further studies are required to more fully elucidate the neural mechanisms underlying auditory impairments in patients with AD and related dementia disorders.

Disclosure Statement {#sec1_5}
====================

The authors have no conflicts of interest to report.

Funding Sources {#sec1_6}
===============

This work was supported by the Japan Society for the Promotion of Science Grants-in-Aid for Young Scientists (B) 25870325 and 17K17811 and Scientific Research (C) 15KT0095 to K.T.

Author Contributions {#sec1_7}
====================

Conception and design of the experiments: M.S., K.T. Performance of experiments: M.A., M.F., H.D., and M.Sh. Data“South Park” and Record Store Day aren’t two things that naturally associate themselves with one another, but that’s what’s happening this year, as the long-running Comedy Central show is releasing a limited-edition vinyl record in conjunction with the annual day celebrating independent record stores.

Two songs heard on the series, “San Diego” and “Gay Fish,” are being released on a 7-inch vinyl record limited to 2,000 copies.

Record Store Day is celebrated on the third Saturday in April. This year, that’s April 20.

“San Diego” was first heard in the Season 16 episode “Butterballs,” while the Kanye West-inspired “Gay Fish” was heard in the Season 13 episode “Fishsticks.”

“South Park” has always had a penchant for music (creators Matt Stone and Trey Parker also did their own musical, “Book of Mormon”), but


         \usepackage{upgreek}
                \setlength{\oddsidemargin}{-69pt}
                \begin{document}$$\text {PE}_{\gamma }$$\end{document}$, accelerators for all tasks related to *T* are spread in the vicinity of $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}
                \usepackage{amsfonts}
                \usepackage{amssymb}
       \begin{document}$${>}0$$\end{document}$ for *T* in cycle $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}
                \usepackage{amsfonts}
                \usepackage{amssymb}
                \usepackage{amsbsy}
                \usepackage{mathrsfs}
                \usepackage{upgreek}


           \usepackage{amssymb}
                \usepackage{amsbsy}
                \usepackage{mathrsfs}
                \usepackage{upgreek}
                \setlength{\oddsidemargin}{-69pt}
                \begin{document}$$mv + m$$\end{document}$ non-running tasks) will be assigned, taking $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
               \usepackage{amsbsy}
                \usepackage{mathrsfs}
                \usepackage{upgreek}
                \setlength{\oddsidemargin}{-69pt}
                \begin{document}$$\begin{aligned} \sum _{i=1}^{k}i^{\overline{m}}&= m!\cdot \sum _{i=1}^{k}\frac{i^{\overline{m}}}{m!} = m! \cdot \sum _{i=1}^{k} \left( {\begin{array}{c}i+m-1\\ m\end{array}}\right) = m! \cdot \sum _{i=m}^{k+m-1}\left( {\begin{array}{c}i\\ m\end{array}}\right) \end{aligned}$$\end{document}$$This sum can now be simplified using the identity $\documentclass[12pt]{minimal}
                \usepackage{amsmath}


   \setlength{\oddsidemargin}{-69pt}
                \begin{document}$$0 \le X \le mv$$\end{document}$ holds: In case the *m* lowest-priority tasks are running on $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}
                \usepackage{amsfonts}
                \usepackage{amssymb}
                \usepackage{amsbsy}
                 \usepackage{amssymb}
                \usepackage{amsbsy}
                \usepackage{mathrsfs}
                \usepackage{upgreek}
                \setlength{\oddsidemargin}{-69pt}
                \begin{document}$$v=6$$\end{document}$

Equation [1](#Equ1){ref-type=""} now allows us to calculate $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}


      (p)etabytes, (e)xabytes.  Capitalise to use multiples of 1000 (S.I.)
       instead of 1024.  Can also specify custom units e.g. --units 3M

Example
You can override the units like so:
$ pvs --units m
  PV         VG             Fmt  Attr PSize     PFree
  /dev/sda2  vg_switchboard lvm2 a--  37664.00m    0m

A:

Well, I said I'd give you a one liner so here it is but it really is not very good. @slm's answer is obviously the way to go. Anyway, the one-liner below assumes that the PV size is expressed in KByteshistory before turning 80.

Just don't look for him to change.

"It is a bigger burden on him now," says Christopher Landau, an appellate lawyer who clerked for Thomas during his first term in 1991-92. "After 25 years, he's still pretty much the justice he was in year one, and that's often not the case on the Supreme Court."

The 43-year-old rookie justice waited less than five months after his bruising Senate confirmation fight before casting his first solo dissenting vote. He argued that a prison escapee's membership in a white racist prison gang was relevant at his sentencing for murder, in part to help rebut testimony "that he was kind to others."

The lone dissent served as a marker that Thomas, whose elevation to the nation's highest court followed explosive allegations


and planning frequently result in project failure. Poor budgeting and resourcing came have the same effect. The biggest reason for failure is often scope creep, wherein the project keeps expanding over time, with more and more features being added. Unplanned feature creep can be like building a four-story house on a foundation for a bungalow – the architecture simply cannot support the weight.

This article was written to alert you to the complexity and risk inherent in project management. It does not recommend whether it is better to bring in a professional project manager or whether it is safe to go it alone. However, I would recommend that you consider the pitfalls and that you plan properly and extensively, regardless of the choice you make.

There are a number ofa genomic rescue transposon, *P\[Top2-w^+^\]*, on the third chromosome. *P\[Top2-w^+^\]* carries a *mini-white* gene and a 7.1-kb *Hin*dIII to *Xba*I genomic fragment that includes the wild-type *[Top2](http://flybase.org/reports/FBgn0003732.html)* gene and part of the *[CG10026](http://flybase.org/reports/FBgn0032785.html)* gene ([Figure 1B](#fig1){ref-type="fig"}). As a control, we demonstrated that *P\[Top2-w^+^\]* rescued the recessive lethality associated with *Top2^Df17^/Top2^Df35^* ([Table S3](http://www.genetics.org/lookup/suppl/doi:10.1534/genetics.112.144006/-/DC1/genetics.112.144006-3.pdf)), wherein *Top2^Df17^/Top2^Df35^*; *P\[Top2-w^+^\]/+* individuals were produced at 86% of the *Top2^Df17\ or\ Df35^/CyO*, *[y^+^](http://flybase.org/reports/FBal0190963.html)* class.

Characterization of newly generated *Top2* mutant alleles {#s4}
---------------------------------------------------------

Several studies were conducted to characterize the new *Top2^m^* alleles. First, we determined whether alleles displayed parent-of-origin effects by crossing *y^1^w^67c23^*; *Top2^m^/CyO*, *[y^+^](http://flybase.org/reports/FBal0190963.html)* males or females to *y^1^w^67c23^*; *Top2^Df9043^/CyO*, *[y^+^](http://flybase.org/reports/FBal0190963.html)* individuals of the opposite sex and scoring whether *Top2^m^/Top2^Df9043^* adults survived. Second, we assessed whether *Top2^m^* alleles were temperature sensitive by crossing *y^1^w^67c23^*; *Top2^m^/CyO*, *[y^+^](http://flybase.org/reports/FBal0190963.html)*


CA; no. 28104) and sequenced at the University of Iowa DNA Core Facility. Primers are listed in [Table S1](http://www.genetics.org/lookup/suppl/doi:10.1534/genetics.112.144006/-/DC1/genetics.112.144006-5.pdf). Western analysis was used to determine the level of Top2 protein generated in each strain. For these studies, proteins were extracted from a collection of brain, imaginal disc, and salivary gland tissues dissected from 10 *Top2^m^/Top2^Df9043^* larvae. Two primary antibodies were used to detect Top2: rabbit anti-Top2 (T. Hsieh) at 1:10,000 ([Figure 3](#fig3){ref-type="fig"}) and rabbit anti-Top2 (D. Arndt-Jovin) at 1:4000 (data not shown). HRP-conjugated goat anti-rabbit IgG secondaries \[Bio-Rad, Hercules, CA; no. 172-1019\] were used at 1:20,000.

![Analyses of protein production in *Top2* mutations. (A) The locations of the nonsense and missense mutations in the lethal *Top2* alleles are shown relative to the Top2 protein domain structure. Abbreviations are described(*dp cn bw*)\*/*Top2^Df17\ or\ Df35^* females with reduced pigmentation from *y^1\#8^/y^1\#8^*; (*dp cn bw*)\*/*Top2^Df17\ or\ Df35^* females arising from nondisjunction of the *X* chromosome.

From 2653 F~1~ females, we identified 12 straight-winged females that had altered cuticle pigmentation. At least 4 of these females showed an unambiguous, uniform light cuticle color, resembling females in which *[y](http://flybase.org/reports/FBgn0004034.html)* pairing had been disrupted ([@bib11]; [@bib43]). Seven of these exceptional females were successfully mated and all produced males with the light cuticle pigmentation characteristic of the *[y^1\#8^](http://flybase.org/reports/FBal0036033.html)* allele, which was presumed to have been inherited from their mother. The recovery of such males is consistent with the parental exceptional females being *y^2^/y^1\#8^*; (*dp cn bw*)\*/*Top2^Df17\ or\ Df35^*, with such females carrying a mutant *[Top2](http://flybase.org/reports/FBgn0003732.html)* allele that encoded a protein that was unable to


                 No

ND, not determined; NA, not applicable.

Boldface type: invariant between human Top2α and -β, mouse Top2α and -β, and yeast Top2.

TDD, **T**rans**d**ucer **d**omain; TOPRIM, **To**poisomerase/**Prim**ase domain; WHD, **W**inged **h**elix **d**omain.

Protein accumulation as assayed by Western analysis (*+++*, protein levels equal to wild type; ++, intermediate levels; +, low levels; +/−, very low levels; ---, no protein relative to wild-type).

Complementation with other *Top2* alleles.

Denotes nonsense mutation.

We determined the levels of Top2 protein produced in the 14 *[Top2](http://flybase.org/reports/FBgn0003732.html)* strains that carry lethal alleles. Our Western analyses used two polyclonal antibodies raised against the full-length Top2 protein, which was especially important for optimizing the detection of mutant proteins obtained from strains carrying nonsense mutations. Similarresults were obtained using both antibodies ([Figure 3B](#fig3){ref-type="fig"}, [Table 1](#t1){ref-type="table"}, and data not shown). We found that Top2 was at low levels or absent in 7 strains, including all 4 strains carrying nonsense mutations and 3 strains carrying missense mutations, while the remaining 7 strains carrying missense mutations displayed intermediate to high protein levels. In general, Top2 proteins that carried changes in the TOPRIM domain accumulated high levels of protein, while those with amino acid substitutions in the ATPase domain or WHD produced varying levels of protein. *Top2^35-3^* produces low levels of protein even though the translation initiation ATG codon is mutated. This protein may arise from a low frequency of initiation at the nearby in-frame ATG codon located 12 codons downstream of the *bona fide* initiator, leading


or\ Df35^*/*Top2^Df9043^* null larvae survived to pupation ([Table 2](#t2){ref-type="table"}), implying a lethal phase that is later than previously reported. Similar results were obtained for *Top2^m^/Top2^Df9043^* mutant larvae carrying nonsense alleles, wherein 38--66% of mutant larvae survived to pupal stages ([Table 2](#t2){ref-type="table"}). Finally, we studied *Top2^m^/Top2^Df9043^* larvae carrying *[Top2](http://flybase.org/reports/FBgn0003732.html)* missense alleles. We found that seven *Top2^m^/Top2^Df9043^* genotypes demonstrated significantly enhanced survival relative to the known null genotypes, wherein 80--92% of mutant larvae became pupae (*P* \< 0.04; [Table 2](#t2){ref-type="table"}). We note that one genotype, *Top2^35-3^/Top2^Df9043^* (*P* \< 0.0002; [Table 2](#t2){ref-type="table"}) demonstrated significantly decreased survival relative to the null genotypes. Whether this difference reflects an unrelated influence of the genetic background or a special feature of *Top2^35-3^* is unclear. For example, Top2^35-3^ may exert antimorphic effects, as it is predictedcontrast, *Top2^17-2^*/*Top2^Df9043^* larvae that produce very low levels of a mutant protein contain small brains and no imaginal discs when grown at the nonpermissive temperature, but larger brains and discs when grown at the permissive temperature ([Figures 3B](#fig3){ref-type="fig"} and [4B](#fig4){ref-type="fig"}). To assess the level of mitosis in brains and imaginal discs obtained from *Top2^17-6^/Top2^Df9043^* and *Top2^17-2^*/*Top2^Df9043^* larvae, dissected tissues were stained with an antibody against phosphorylated serine 10 of histone H3, which is a highly selective marker for mitotic cells ([@bib29]). These experiments revealed that the reduced size of brains and discs correlates with decreased staining of phosphorylated serine 10 of histone H3 ([Figure 4, B and C](#fig4){ref-type="fig"}), consistent with reduced levels of mitosis. Taken together, these data suggest that defects in imaginal disc growth may contribute to


of the MSL complex that is responsible for interphase phosphorylation of histone H3 Ser10 in interphase cells ([@bib21]). The dosage compensation pathway is required for increasing transcription from the single male *X* through recruitment of the **M**ale **S**pecific **L**ethal (MSL) complex, which leads to increased acetylation of lysine 16 of histone H4 (H4K16ac) ([@bib25]; [@bib17]). To investigate whether the puffy *X* phenotype in *[Top2](http://flybase.org/reports/FBgn0003732.html)* mutant males resulted from altered dosage compensation, we examined *X* chromosome localization of components of the MSL complex in *Top2^17-5^*/*Top2^Df9043^* and *Top2^35-14^*/*Top2^Df9043^* male larvae. We found that loss of Top2 neither affects recruitment of MSL1, MLE, or JIL-1 nor alters enrichment of H4K16ac on the male *X* chromosome ([Figure 5, D--F and G--I](#fig5){ref-type="fig"}; data not shown).

Previous studies demonstrated that Imitation Switch (ISWI) regulates higher-ordertornado with peak wind speeds of 115 mph touched down in Mount Juliet. No serious injuries were reported there, though the path of damage was about 150 yards wide, including homes, a warehouse and an automotive business.

At a shopping center in Mount Juliet, large sheets of metal littered the parking lot, light poles were knocked down and bits of fiberglass insulation were stuck in the trees.

One wall of a Dollar General convenience store collapsed, and the roof was torn off. Mark Fulks Jr. runs Mark's Automotive with his father in a building attached to the Dollar General. The garage door was blown off his shop and sitting on one of the cars inside, and Fulks said several of the cars they were working on had their windshields blown


column. Then we apply your code to label the height percentile only on the data that falls in that age range.
Here is some of the data.table after the for loop. Is this what you were looking for?
        age   height        new.percentile
    1: 3.826293 1.049781            p50
    2: 3.903765 1.116287            p75
    3: 3.931612 1.075756            p75
    4: 3.940625 1.165758          layer of ice that forced maintenance crews to hack away the ice around the door to reach the men. If an illness, accident, or fire occurred at the Stannard Rock Light it could be days or even weeks before the keepers got assistance. As one of the rock lighthouses, it was designated as a "stag station" where only men could serve without their families. The keepers called the Stannard Rock Light the "Loneliest Place in the World" and it has always carried the distinction of being the "loneliest place" in the continental United States. Maritime historian Wes Oleszwski reported that duty at the Stannard Rock Light was so rough that of the keepers and assistant keepers, there were four resignations and three transfers in the first three seasons


ostensibly been attempting to enter Israel to attend a follow-up appointment at the Soroka Medical Center in Beersheva, questioning revealed that it had been her intent to detonate the payload she’d been carrying at that institution. The would-be bomber had been treated there five months previous for severe burns received after a gas canister exploded on a fire while she was cooking at her refugee camp home in the Gaza Strip.

Additional information:

Attack by Female Suicide Bomber Thwarted at Erez Crossing (Israel Ministry of Foreign Affairs)

Last updated: 22 July 2014

Sources:said August 25th; that on the 28th, a 90-foot string of conductor pipe was installed and there then followed a delay until August 31st in order to allow the cement to set, when, on said date, drilling was resumed and was thereafter diligently and uninterruptedly prosecuted down to a depth of 12,200 feet, but, again, without success; which caused the abandonment of said second well on December 17, 1939.
During the course of the trial it was admitted by defendant Grandison Company *771 that not all of the Harrison lands are contiguous; and that, as to such tracts as defendant specifically admitted to be noncontiguous to the well-sites, the drilling of Grandison No. 1 and Grandison No. 2, respectively, did not interrupt the running of the 10-year prescription for


hatched area on said DeArmas sketch, within T. 19 S., R. 23 E., and the north half (N½) of T. 20 S., R. 23 E., except the island in Lake Enfermer (or Renfermé) delineated in red, is still subject to the reserved mineral servitude of August 28, 1929. Plaintiff Harrison, on the other hand, sought to materially restrict the present servitude coverage, contending that within the limits of said hatched area are beds of navigable streams which (so he averred) are the property of the State of Louisiana, with the necessary result that then there is absent that continuity and contiguousness *772 of area which would have otherwise made the reservation of the oil, gas and mineral rights (in its application to said particular area) the retention ofarea is broken and defendant's claim of a still-existent mineral servitude cannot be justified with respect to such area as is separated and disconnected by said (alleged) State-owned bayou bed from the Grandison No. 1 well-site.
It is admitted that Bayou L'Ours, if it actually was a navigable stream in 1812, is no longer such.
It is also argued on behalf of plaintiff that other named bodies of water are navigable at the present time and separate and disconnect portions of the aforementioned composite hatched area from the Grandison No. 1 well-site area; or, in the alternative, if such water bodies are not now navigable, then their bottoms or beds as well as the bottom or bed of Bayou L'Ours  whether such bodies and such bayou were navigable or


to discover and develop oil, gas or other minerals, which effort persisted from the commencement of the exercise of the mineral servitude (before the expiration of ten years from August 28, 1929,) on said August 25, 1939, up to December 17, 1939, when said Grandison No. 2 was abandoned as a dry hole.
It is, however, contended by counsel that, as was held in Louisiana Petroleum Company v. Broussard, 1931, 172 La. 613, 135 So. 1, the use of a servitude which interrupts the nonusage prescription of 10 years prescribed by Arts. 789 and 3546 (La.) R.C.C., must be that character of use as was in contemplation of the parties to the *775 servitude grant or reservation; and contends that since the commencement (within the ten years) of the    {
            Z = 100,
            Name4Classes = new List<Class1>
                {
                    new Class1 {Id = 1, Naming = NamingConvention.Name1},
                    new Class1 {Id = 2, Naming = NamingConvention.Name2},
                    new Class1 {Id = 3,


 dtype=np.float32)
        for ix, in_ in enumerate(inputs):
            input_[ix] = caffe.io.resize_image(in_, self.image_dims)

        if oversample:
            # Generate center, corner, and mirrored crops.
            input_ = caffe.io.oversample(input_, self.crop_dims)
        else:
            # Take center crop.
            center = np.array(self.image_dims) / 2.0
            crop = np.tile(center, (1, 2))[0] + np.concatenate([
    """
        if self.application.verbose:
            print(message)
        msg = tornado.escape.json_decode(message)

        if msg["type"] == "get_step":
            if not self.application.model.running:
                self.write_message({"type": "end"})
            else:
                self.application.model.step()
                self.write_message(self.viz_state_message)


"autoreload": False,
        "template_path": os.path.dirname(__file__) + "/templates",
    }

    EXCLUDE_LIST = ("width", "height")

    def __init__(
        self, model_cls, visualization_elements, name="Mesa Model", model_params={}
    ):
        """ Create a new visualization server with the given elements. """
        # Prep visualization elements:
        self.visualization_elements = visualization_elements
        self.package_includes = set()
        self.local_includes = set()
        self.js_code = []
        for element in self.visualization_elements:
      ):  # static_text is never used for setting params
                    continue
                model_params[key] = val.value
            else:
                model_params[key] = val

        self.model = self.model_cls(**model_params)

    def render_model(self):
        """ Turn the current state of the model into a dictionary of
        visualizations


Q:

Powershell json RESTful api - Conditional Statement

Currently, I am attempting to write a conditional statement that states the following
If($JSON.response = false){
'Dont do anything and continue to the next block of code.'
}

Right now the JSON returns like this when there is no data:
 response_code response
 ------------- --------
             0 {}

This is what I have so far:
If($json.response = 0){
'Dont do anything here'
}elseif($json.response = 1){
'Do the code'
}

I'd like to add that response_code is always equal to 0 when the response is error free as in status code 200. However, when there are no fields returned response is just an empty hashtable.

A:

I found the answer since the object is an array it was best to roll out like this.
 If($json.object.CountCarolyn:  Please add me to the attendance list.

Sara Shackleton
Enron North America Corp.
1400 Smith Street, EB 3801a
Houston, Texas  77002
713-853-5620 (phone)
713-646-3490 (fax)
sara.shackleton@enron.com
----- Forwarded by Sara Shackleton/HOU/ECT on 05/15/2001 06:50 PM -----

	Julia Murray@ENRON
	Sent by: Carolyn George@ENRON
	05/15/2001 03:59 PM

		 To: Alan Aronowitz/HOU/ECT@ECT, Sandi M Braband/HOU/ECT@ECT, Teresa G
Bushman/HOU/ECT@ECT, Michelle Cash/HOU/ECT@ECT, Barton Clark/HOU/ECT@ECT,
Harry M Collins/HOU/ECT@ECT, Peter del Vecchio/HOU/ECT@ECT, Stacy E
Dickson/HOU/ECT@ECT, Shawna Flynn/HOU/ECT@ECT, Barbara N Gray/HOU/ECT@ECT,
Wayne Gresham/HOU/ECT@ECT, Mark E Haedicke/HOU/ECT@ECT, Leslie
Hansen/HOU/ECT@ECT, Jeffrey T Hodge/HOU/ECT@ECT, Dan J Hyvl/HOU/ECT@ECT, Anne
C Koehler/HOU/ECT@ECT, Dan Lyons/HOU/ECT@ECT, Kay Mann/Corp/Enron@Enron,
Travis McCullough/HOU/ECT@ECT, Lisa Mellencamp/HOU/ECT@ECT, Janet H
Moore/HOU/ECT@ECT, Julia Murray/HOU/ECT@ECT, Gerald Nemec/HOU/ECT@ECT, David
Portz/HOU/ECT@ECT, Michael A Robison/HOU/ECT@ECT, Elizabeth
Sager/HOU/ECT@ECT, Richard B Sanders/HOU/ECT@ECT, Lance
Schuler-Legal/HOU/ECT@ECT, Sara Shackleton/HOU/ECT@ECT, Carol St
Clair/HOU/ECT@ECT, Lou Stoler/HOU/ECT@ECT, Mark Taylor/HOU/ECT@ECT, Sheila
Tweed/HOU/ECT@ECT, Steve Van Hooser/HOU/ECT@ECT, John
Viverito/Corp/Enron@Enron, Ann Elizabeth White/HOU/ECT@ECT, Donna


the nation. In 2013, more than 630,000 vehicles moved through the port.

View high resolution photos of today’s event including the mayor riding in the first car, and Jaxson De Ville and Southpaw hamming it up.the subjects\' LDL peak particle size (pps).

Apolipoprotein B in serum was measured by turbidimetric immunoassay using a commercially available kit (Incstar, Stillwater, MN) according to procedures outlined by the manufacturers. All apolipoprotein B procedures have been developed in accordance with the guidelines set forth by the International Federation of clinical chemistry.

Fasting glucose levels were determined spectrophotometrically at a wavelength of 340 nm using a hexokinase reaction developed by Roche (Roche Diagnostic System, Nutley, NJ). Serum insulin was measured by radioimmunoassay of serum using a Coat-A-Count insulin procedure (Diagnostic Products, Los Angeles, CA). The insulin resistance was assessed by using the homeostasis model assessment (HOMA) index, which divides the product of fasting insulin (*μ*U/mL) and glucose (mmol/L) by 22.5 \[[@B19]\].

Serum SHBG was analyzed by immunoradiometric assay (Siemens Health Care Diagnostics;


correlations were also conducted after controlling for VAT and insulin.

3. Results {#sec3}
==========

3.1. Descriptives {#sec3.1}
-----------------

A total of 66 subjects, 36 CA and 30 AA women, were evaluated for subject characteristics. A comparison between groups indicated that CA women had significantly higher VAT and TG levels than AA women (*P* \< .05 for both). There was also a trend toward significant differences in waist circumference (*P* = .058), age (*P* = .063), and SHBG (*P* = .073). No other significant differences or trends in metabolic variables were noted between groups.

3.2. Association between Total Testosterone and the Metabolic Risk Profile {#sec3.2}
--------------------------------------------------------------------------

Pearson\'s correlation coefficient showed a significant inverse correlation between TT and BP (*P* = .014 and *P* = .004 for SBP and DBP, resp.) indicating that higher TT was associated with lower BPobserved for TT, significant relationships between FAI and DBP (*P* = .018), total cholesterol (*P* = .009), LDL (*P* = .010), and Apo B (*P* = .029) were found for AA women. Controlling for VAT had no impact upon aforementioned relationships in either CA or AA women. Controlling for insulin, however, negated all significant relationships between FAI and HOMA IR as well as serum lipid and lipoproteins in both CA and AA women.

3.4. Association between Sex Hormone Binding Globulin and the Metabolic Risk Profile {#sec3.4}
------------------------------------------------------------------------------------

In CA women, SHBG was significantly and positively related to waist circumference (*P* = .031), VAT (*P* = .004), glucose (*P* = .009), insulin (*P* = .001), and HOMA IR (*P* = .001). In AA women, the only significant associations were observed between SHBG


and waist circumference (*P* = .022). However, there was a trend toward significant relationships between SHBG and VAT (*P* = .096), insulin (*P* = .056), HOMA IR (*P* = .090), and HDL (*P* = .094) in AA women. Adjusting for insulin negated all significant correlations in both CA and AA women. Adjusting for VAT negated the significant relationship between SHBG and waist circumference in AA women.

4. Discussion {#sec4}
=============

The present study revealed several interesting findings relevant to sex steroids, SHBG, and the MRP in CA and AA women. As expected, CA women showed higher VAT and TG levels than AA women, which had been reported in previous studies \[[@B26], [@B27]\]. After controlling for VAT, however, there were no longer significant differences in TG levels between groups indicating that lowerbeen better to obtain multiple samples particularly in a cross-sectional study. Furthermore, an *n* of 66 subjects which included a biracial group of women, limited our power. Since this was a cross sectional study, it was difficult to determine any temporal or causal relationships between sex steroids, SHBG, and the MRP. We could only speculate primary relationships based upon the strength of the correlation analysis before and after controlling for potential confounders, that is, VAT and insulin. Since many variables were correlated with each other, it was difficult to determine if some relationships were operating independently or via their association with other metabolic variables. Although women were recruited from the same medical institution and consisted of nurses, nurse assistants, and technicians, it would have been helpful to examine


the date of the article. As the article ages, some links may become invalid

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LUA: Avoiding passing by reference

I'm just starting to learn LUA and I've got an issue that I'm unsure which way to "properly" solve.
When I pass a Defold vmath.vector3 to my function it appears to be passed by reference and is therefore altered.
If I multiply it by anything this is solved however.
Is there another more correct way to solve this? I don't want to modify the original vector that I pass as an argument.
function M.get_nearest_tile(x, y)
    if y then -- if we've got 2 inputs, use x & y
        x = math.floor(x / M.TILE_SIZE)
        y = math.floor(y / M.TILE_SIZE)
        return x, y


and they scored the most any team has at Michigan Stadium since Florida State had 51 in 1991. It was also the Illini's first victory at the Big House since 1999, and University of Illinois quarterback Isiah "Juice" Williams set a Big House record with 431 all-purpose yards, breaking the record previously held by former Illini quarterback Tony Eason (403). Illini quarterback Isiah "Juice" Williams connected with Jeff Cumberland for a 77-yard pass, the longest by an Illini quarterback since 1985, and a perfectly lofted screen to running back Daniel Dufrene turned into a 57-yard TD. With the loss, the Wolverines fell to 2–3 on the season and 1–1 in the Big Ten, their worst record after five games since starting 1–4 in 1967, two years before BoWolverines fell to 2–6 overall and 1–3 vs. Big Ten opponents.

at Purdue

Recap: Week 10

In week 10, the Wolverines traveled to West Lafayette, Indiana to take on the Purdue Boilermakers. The Wolverines gained an early lead in the first quarter. First Brandon Minor ran in a TD from 45 yards out. A few minutes later Martavius Odoms got a huge score when he ran a punt back 73 yards for another TD, putting the Wolverines up 14-0. The Boilermakers quickly tied it up though with 2 TD's of their own later in the first quarter. First Kory Sheets ran in TD from 2 yards out. Then Justin Siller ran in a TD from 10 yards out. The Wolverines went up by 14 again in the second quarter though. First


Laterryl Savoy scored on an 11-yard TD pass. Then the Wolverines got another big TD run, this time on a 51-yard rush by Darryl Stonum. The Boilermakers struck back with less than a minute to go in the half when Kory Sheets scored another TD, this time on a 3-yard run. At halftime the Wolverines were up 28–21.

In the 3rd quarter, the Wolverines were shut out, but the Boilermakers scored 2 more TD's, both by Kory Sheets, making his day's total 4. His 3rd of the game came on a 7-yard pass, tying the game. His final TD of the game was on a 5-yard run which put the Boilermakers ahead.

The scoring continued to see-saw in the fourth quarter. The Wolverines tied it back up when Brandon Minorthe Ohio State Buckeyes for the 105th time in the rivalry (see Michigan-Ohio State rivalry). The Buckeyes scored first when Chris Wells ran in a 59-yard TD. The Buckeyes made it 14-0 when Brian Hartline caught a 53 yard long bomb for another TD just after the start of the second quarter. Michigan got their only points of the game when Brandon Minor ran in a 1-yard TD near halftime.

The second half was all Ohio State. First Daniel Herron got a huge 49-yard run for a TD in the 3rd quarter. Later in the 3rd, Brian Robiske caught an 8-yard TD pass. Just after the start of the 4th, Daniel Herron scored again, this time on a 2-yard TD run. Brian Hartline later caught an 18-yard TD pass.

With


the restriction $\omega|_{{\widetilde{X}}\setminus N}$ to a $C^\infty(2,0)$–form $\tilde{\omega}$ on ${\widetilde{X}}$. The $\bar{\partial}\tilde{\omega}$ is a compactly supported $C^\infty(2,1)$–form, hence determines a class in $H^1_c({\widetilde{X}},\Omega^2)$. If $\tilde{\omega} $ is a holomorphic extension then $\bar{\partial}\tilde{\omega}=0$. Next, let $\lambda$ be a $C^\infty(0,1)$ form in ${\widetilde{X}}$. Then the duality $ H^1({\widetilde{X}},{{\mathcal O}}_{{\widetilde{X}}})\otimes H^1_c({\widetilde{X}},\Omega^2)\to {{\mathbb C}}$ is the perfect pairing $$\langle [\lambda],[\bar{\partial}\tilde{\omega}]\rangle=\int_{{\widetilde{X}}}\
\lambda\wedge \bar{\partial}\tilde{\omega}.$$ Assume that the class $[\lambda]\in H^1({\widetilde{X}},{{\mathcal O}}_{{\widetilde{X}}})$ is realized by a $\check{C}ech$ [*cocyle*]{} $\lambda_{ij}\in {{\mathcal O}}(U_i\cap U_j)$, where $\{U_i\}_i$ is an open cover of $E$, $U_i\cap U_j\cap U_k=\emptyset$, and each connected component of the intersections $U_i\cap U_j$ is either a coordinate bidisc $B=\{|u|<2\epsilon,\ |v|<2\epsilon\}$ with coordinates $(u,v)$, such that $E\cap B\subset  \{ uv=0\}$ or a punctured coordinate bidisc $B=\{\epsilon/2<|u|<2\epsilon,\ |v|<2\epsilon\}$ with coordinates $(u,v)$, such that $E\cap B=  \{ v=0\}$.for each vertex $v_2 \in {{\mathcal V}}_2$ which has got a neighbour in ${{\mathcal V}}_1$ let’s fix a cut $D_{v_2}$ on ${\widetilde{X}}_1$ along we glue the exceptional divisor $E_{v_2}$. If for some vertex $v_2 \in {{\mathcal V}}_2$ which has got a neighbour in ${{\mathcal V}}_1$ there isn’t a fixed cut, then we glue the exceptional divisor $E_{v_2}$ along a generic cut.

We know that the tubular neighbourhood of the exceptional divisors are analitycally taut, so let’s plumb the tubular neihgbourhood of the vertices in ${{\mathcal V}}_2$ with the above conditons generically to the fixed resolution ${\widetilde{X}}_1$, now we get a big singularity ${\widetilde{X}}$ and we say that ${\widetilde{X}}$ is a relatively generic singularity corresponding to the analytical structure ${\widetilde{X}}_1$ and the cuts $D_{v_2}$.

We want to explain a little bit


$h^1(Z_1, {\mathfrak{L}})$ in $H^1(Z)$, which gives the desired $h^1(Z, {\mathcal{L}}) = h^1(Z_1, {\mathfrak{L}})$.

Let’s notice, that the following theorem from [@NNA2] is an immediate consequence of our main theorem:

\[th:CohNat\] Assume that $(X,o)$ is generic with a fixed resolution graph $\mathcal{T}$, and we choose an effective cycle $Z$ and $l'\in L'$. Assume that the last term $(l'_t,Z_t)$ of the Laufer type computation sequence $\{(l'_k,Z_k)\}_{k=0}^t$ has the following property: if $l'_t=\sum_v l'_{t,v}E_v$, then $l'_{t,v}<0 $ for any $v\in {{\mathcal V}}(|Z_t|)$. Then $h^i(Z,{{\mathcal O}}_Z(l'))=h^i(Z,{\mathcal{L}}_{gen})$ for a generic line bundle ${\mathcal{L}}_{gen}\in{{\rm Pic}}^{l'}(Z)$ ($i=0,1$).

Corollaries of the main theroems
================================

As a first consequense of our main theorems we will define and characterise the analouge of rational singularities in the case of the relative setup. Let’s recall, that a singularity ${\widetilde{X}}$ with resolution graph $\mathcal{T}$ is calledlet’s look at a cycle $ l_2 = l_1 + m E_{w'}  + n  E_{w}$, where $l =  l_1 + m E_{w'}  \leq Z_{{\bf s}}$, then we have:

$$( (- l'_{s_{v, k}}, l_2) - \chi(l_2) ) - ( (- l'_{s}, l) - \chi(l)) = m - n - \chi ( (n-m) E_{w})$$

Now we can calculate easily that $ m - n - \chi ( (n-m) E_{w}) \leq 1$ and $ m - n - \chi ( (n-m) E_{w}) = 1$ if $m-n = 1$ and $ m - n - \chi ( (n-m) E_{w}) \leq 0$ if $ n \geq m$.

This means on the one hand that indeed $  a_{{\bf s}^{v, k}} - a_{{\bf s}} \in (0, 1) $.

On the other hand we got,


Moreover, faster GFR decline is associated with more significant cognitive decline.^[@R7]^ These observations are consistent with accumulated data showing an increase in the risk of coronary heart disease in patients with mild to moderate CKD. Hence, CKD is considered a manifestation of vascular diseases.

Patients with CKD have a 100% higher risk of cardiovascular diseases, and many studies have shown that cardiovascular diseases are associated with dementia.^[@R8]--[@R11]^ The incidence of dementia among Taiwanese people aged 65 years and older increased from 4.1% in 1980 to 10.2% in 2007. A study of the population of Taiwan revealed that the prevalence of dementia was ∼1.7% to 4.3% among elderly people.^[@R12]^ In Taiwan, the high prevalence of CKD may be correlated with dementia. Establishing health policies for reducing dementia risk in patientsprotective effect of vaccination is specific to the influenza season, evaluating the noninfluenza season could indicate the possible contribution of bias to the estimates observed during the influenza season. The relationship between the seasonal effect of vaccination and dementia risk was also analyzed. The cumulative incidence of dementia in vaccinated and unvaccinated CKD patients was estimated using the Kaplan--Meier method. To examine the effect of the total number of vaccinations on the cumulative incidence of dementia, we categorized patients into 4 groups according to the vaccination status: unvaccinated and 1, 2 to 3, and ≥4 total vaccinations.

A time-dependent Cox proportional hazard model was used to calculate the hazard ratios (HRs) of dementia among vaccinated and unvaccinated patients with CKD. The HRs were adjusted for age, sex, baseline comorbidities,


significance of the observed effects, it is unlikely that these limitations compromised the results. Finally, our study is not a prospective randomized blinded study; hence, a cause--effect relationship could not be established. The findings of this study suggest that influenza vaccination exerts a significant protective effect against dementia in CKD patients with dementia risk factors by reducing the incidence of dementia. Additional randomized studies are required to verify these findings.

CONCLUSIONS
===========

Influenza vaccination exerts dose--response and synergistic protective effects against dementia in CKD patients with dementia risk factors by reducing the incidence of dementia.

Abbreviations: PS = propensity score, ACEI = angiotensin-converting enzyme inhibitor, AD = Alzheimer disease, CKD = chronic kidney disease, ESRD = end-stage renal disease, GFR = glomerular filtration rate, HRs = hazard ratios, ICD-9-CM = International Classificationinflammation in relevant ocular tissues, such as the lacrimal and meibomian glands. The use of various compounds to treat dry eye patients, such as steroids e.g. U.S. Pat. No. 5,968,912; Marsh, et al., Topical nonpreserved methylprednisolone therapty for keratoconjunctivitis sicca in Sjogren syndrome, Opthalmology, 106(5): 881-816 (1999); Plugfelder et al, U.S. Pat. No. 6,153,607]; cytokine release inhibitors (Yanni, J. M.; et al WO0003705 A1), cyclosporine A [Tauber, J. Adv. Exp. Med. Biol. 1998, 438, (Lacrimal Gland, Tear From and Dry Eye Syndromes 2), 969] and 15-HETE (Yanni et al., U.S. Pat. No. 5,696,166) has been disclosed.
In addition to dry eye, Jak3 inhibitors may be useful in the treatment of other inflammation-linked ocular disorders, including but not limited to glaucoma, uveitis, diabetic retinopathy and age-related macular degeneration. A CNIB-funded


(EoE) and ocular angiostrongyliasis \[[@B2],[@B8]\].

Nomura and Lin reported the first human infection with *A. cantonensis*in Taiwan in 1945. Following that, cases were reported in many countries and regions, primarily Australia \[[@B9],[@B10]\], the southwestern Pacific \[[@B11],[@B12]\], southern and southeast Asia, Africa \[[@B13]\], the Caribbean \[[@B14]\] and southeastern USA \[[@B15]\]. Reports of all forms of human angiostrongyliasis are increasing due to frequent international travel \[[@B11],[@B16]-[@B18]\]. The first human case in mainland China was reported in 1984, and only four cases were reported between 1984 and 1994. However, more than 300 cases of human angiostrongyliasis were documented from 1994 to 2006 \[[@B3],[@B19],[@B20]\]. A large outbreak involving 141 patients occurred in 2006 in Beijing, in northern China \[[@B21]\]. Another outbreak involving 33 confirmed cases occurred in 2008 in Yunnan province in southwestern(<http://www.ncbi.nlm.nih.gov/sites/entrez>, Accession Number \[GenBank: [CV826669](CV826669)\~[CV826718](CV826718)\]). And in 2005, Tang, P. and Wang, L.C. submitted 1,226 EST sequences from fifth stage larvae obtained from the brains of laboratory-infected Sprague Dawley rats (<http://www.ncbi.nlm.nih.gov/sites/entrez>, Accession Number \[GenBank: [ND190143](ND190143)\~[ND191368](ND191368)\]). The biology of this nematode is still far from clear. Furthermore, despite the fact that human angiostrongyliasis has become a new public health problem \[[@B34]\], genomic or EST sequencing of *A. cantonensis*are not included in international research plans for the foreseeable future. In this study, we cloned and analyzed full-length cDNA sequences from this nematode, identifying 378 cDNA clusters. By applying bioinformatic and immunogenicity analyses, we have improved our understanding of the basic biology of *A. cantonensis*.

Results
=======

Comparative analysis of sequenced cDNAs
---------------------------------------

As an initial step towards sequencing the transcriptome of this nematode, we constructed


recovered from rats. We analyzed our 378 cDNA clusters from L4 larvae recovered from mouse for correlations with these 1,276 EST sequences. We found that 50 of 378 cDNA clusters covered 190 individual EST sequences (50 EST clusters) of the 1,226 EST sequences from L5 larvae. Especially, we found that 3 cDNAs cluters of COLlagen family members had covered 68 ESTs, more than one third of above 190 individual EST sequencess. And 8 cDNA clusters covered 11 of 50 individual EST sequences (8 EST clusters) from adult worms. In addition, four cDNA clusters were common among L4 larvae, L5 larvae and adult worm cDNA libraries, implying the constitutive expression profile. These four cDNAs were transcripts of myosin light chain family member 3, putative collagen protein 140, putative stress-activatedacids and retinols to specific target tissues \[[@B46]\]. The ADIPOR-like receptor mediates fatty-acid oxidation through activation of AMP kinase and PPAR-alpha \[[@B47]\]. Such information could indicate that *A. cantonensis*obtains lipids from the host to synthesize sterols and fatty acids. In brief, the observed pattern of genes involved in protein metabolism, lipid metabolism and glycolysis may reflect the central nervous system habitat of this pathogen.

Immune responses and diagnostic potential of recombinant protein candidates
---------------------------------------------------------------------------

To identify antigens that might be valuable for diagnosing human angiostrongyliasis, we selected several representative proteins from different cellular location for further study. Four recombinant proteins were successfully purified in the initial attempt. These four proteins were cystatin (possibly extracellular), cathepsin D-like aspartic protease (possibly extracellular), intermediate filaments (IFs; cellular structural component) and lactic acid dehydrogenase (LDH;


peaked on day 14 in all four experimental groups. A control group injected with PBS showed no such response. Thus, all of these four recombinant proteins were capable of inducing an immune response in mice.

After immunizing mice with these recombinant proteins, we challenged experimental and control groups with L3 larvae, and evaluated mouse survival. By day 21 post-challenge, more than 50% of mice had died in the control group and in the experimental groups immunized with recombinant aspartic protease, IFs or LDH. However, 90% of mice survived in the experimental group immunized with cystatin. To confirm the vaccine potential of recombinant cystatin, we examined changes in worm burden in the brains of surviving mice by pathological analysis. We found that there was a significant difference in the averagereading frame; UTR: untranslated region; BBB: blood-brain barrier; ES: excretory/secretory; ELISA: enzyme-linked immunosorbent assay; FRbp: fatty acid and retinol-binding protein; GnRHR: gonadotropin-releasing hormone receptor; IFs: intermediate filaments; LDH: lactic acid dehydrogenase. SD: standard deviations; PBS: phosphate-buffered saline.

Authors\' contributions
=======================

HH contributed to the conception and design of the project, bioinformatics analysis and interpretation of the data, and drafted the manuscript. CM also carried out molecular studies and drafted the manuscript. YX conducted RNA isolation and cDNA library development from larval tissue. MJ contributed to cDNA library construction, candidate protein purification and interpretation of the data. PZ and GP purified candidate proteins and performed mouse immunization experiments. HA, ZX and LZ contributed to the data analysis and discussion. ZX contributed to the conception and design of the project and drafted the


Tetsuya Mizuguchi, founder of development studio Enhance, trying out a PlayStation VR at a Tokyo game show in 2016. Photo : Eugene Hoshiko ( AP )

Sony has continued to do well in the virtual reality space, and has sold a grand total of 4.2 million PlayStation VR systems worldwide, the company announced in a blog post on Monday. That’s total units actually bought by consumers, not just shipped.

“We’re also very excited to reveal that we have officially sold-through more than 4.2 million PS VR systems worldwide as of March 3, 2019,” PlayStation social-media chief Sid Shuman wrote. “We’d like to thank our fans for the amazing support for helping us achieve the milestone.”

As VentureBeat noted, recent estimates have put Sony well ahead of the competition, with industry firmOperational performance and analysis of two rabies vaccination campaigns in N'Djamena, Chad.
Transmission of rabies from animals to people continues despite availability of good vaccines for both human and animal use. The only effective strategy to achieve elimination of dog rabies and the related human exposure is to immunize dogs at high coverage levels. We present the analysis of two consecutive parenteral dog mass vaccination campaigns conducted in N'Djamena in 2012 and 2013 to advocate the feasibility and effectiveness for rabies control through proof of concept. The overall coverage reached by the intervention was >70% in both years. Monthly reported rabies cases in dogs decreased by more than 90% within one year. Key points were a cooperative collaboration between the three partner institutions involved in the control program, sufficient


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#: The size of the resulting hash in bytes.
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that. I think they should be challenging each other and pushing Tajh to make Tajh better. We all know what Tajh has done and it’s really my job as his coach and coordinator to push him out of his comfort zone. “

“He’s swimming right now. He’s paddling and holding his head up. Sometimes he’s got a straw in his mouth trying to breathe. He’s obviously got a lot of talent, but he’s a long ways from where he needs to be, but that’s okay because it’s only after day two. We’re excited about him, but he’s got a long ways to go and he’s got to get serious about everything.”

“We’re trying to put our best on the field and make those moves. We’ve put Sammy out at what


in a microchannel structure that comprise parts at different radial distances from the spinning axis (axis of symmetry). The spinning axis is perpendicular to the plane of the disc. The disc/device is preferably circular and centrifugal force is used in at least a part of each microchannel structures, for instance to take the sample into an MS-port.
Inertia force, such as centrifugal force, may be combined with one or more other kinds of driving forces. The combination may be in the same part of a microchannel structure. The combination may also mean that inertia force is utilized for transport in a part where the flow shall be directed outwards towards the periphery of a circular disc and other forces in some other part for creating a flow inwards or"When you've been thinking about it for ten hours straight." "That's great." "Now I'm late," "Stressed out, and frustrated." "Sorry." "If you give me a minute, I can" "It'll wait." "[sighs]" "You can do it." "Do what?" "(the pretenders) ♪ break up the concrete ♪" "♪ break up the concrete ♪" "♪ break up the concrete ♪" "♫ House 6x13 ♫ 5 to 9 Original Air Date on February 8, 2010" "I thought you were coming in at 7:30." "Rachel woke up with a fever" "And then I..." "Just couldn't get here any sooner." "There's a problem in the pharmacy." "(house) hey, boss lady!" "You don't answer emergency pages anymore?" "Tell them all I'll be by as soon as I can" "And tell him I assumed it was


to help them screw me over?" "I'm not screwing you over." "Well, then give me the script." "It won't help you." "Will it hurt me?" "No, but" "Okay, so it won't harm me and it won't harm you," "But it's this insurance company" "This is not about insurance." "Then give me the damn script." "I'm sick." "I need help." "I need something." "I'm sorry." "Bitch." "[sighs]" "Anyone call?" "Yeah." "The e.R." "They said the vascular who's on call" "Doesn't have privileges." "Then why is he on call?" "Dowd's at a conference and got him to fill in." "Be nice if he got somebody who can actually work here." "Call ereshefsky." "Ereshefsky?" "She's not gonna do it." "She owes me a favor." "She's still not gonna do it." "Allfew minor sutures." "Wait." "Your client accidentally cut his thumb off" "With a table saw, right?" "Yes." "And dr." "Chase reattached it?" "Yes." "You're saying he didn't want it reattached?" "No, he most certainly did not." "His insurance only covered 60% of inpatient expenses," "So he would only agree to the cheapest option." "So what did you tell him?" "I said I'd sew up the skin over the exposed bone." "Then I put him under, got his thumb" "From the paramedics, and reattached it." "What's he gonna do?" "Tell the judge that I harmed him" "By reattaching a vital digit?" "Both he and the insurance company are suing" "To get out of paying the bill." "It's over $80,000." "It was his thumb." "I couldn't just let him toss


BPI, brief pain inventory; PEP, pain education programs; TPE, therapeutic patient education.

In order to improve PEP effectiveness, the administration of programs should be optimized. There is a critical need to specifically train health providers in TPE according to the WHO model.[@CIT0006] This training must be realized by dedicated authorized organisms and is a prerequisite to allow caregivers to be integrated in French TPE programs. In the first step of our research program, 10 nurse--physician pairs benefited from TPE training in order to facilitate harmonization and appropriation of the educational practice. The training involved the entire care staff in order to reach a consensus on modalities for the PEP construction and development as well as for the project implementation.

The present manuscript presents step 2 which aimed to identify thethe intensity, and type and treatment of their pain.

The second part with 9 items addressed patient-reported pain management. It assessed how patients experienced their pain and its impact on daily life, their understanding of it, how they coped with it, and how they discussed it with medical staff and relatives. Each of these items was scored using a visual analogic scale (continuous scale comprised of a horizontal line of 10 cm in length, between two extremes which allows the health professional to score the intensity of the answer between 0 \[not at all\] and 10 \[completely\]).

The third part, given only to patients interested in the educative approach, assessed their knowledge about TPE and need of it. It focused on patients' beliefs about TPE and their willingness to participate


in the program. Patients were also asked to indicate and order their needs and expectations concerning the program and its modalities (individual, collective, or a mixture of individual and group sessions). Finally, they were asked whether they would have accepted to follow the program.

Overall, the questionnaire included 36 questions in total for the three parts, to be completed by the patient ([Figure S1](#SF0001)). Only patients who answered that they were interested in the educative approach on the last question of the second part completed the 9 items of the third part since our purpose was to build a PEP answering to the needs of this patient subset.Figure S1The evaluation regarding cancer pain and patients' educative needs (3 parts, 36 questions in total of the self-reported questionnaire).

### Brief PainInventory (BPI) {#S0003-S2003-S3002}

Pain was assessed using the "Questionnaire Concis sur les Douleurs", a validated French version of the BPI,[@CIT0015] commonly used in research protocols.[@CIT0008] The short version has been validated in French,[@CIT0016] and the French Authority for Health recommends the use of subscale 9 to assess quality of life in patients suffering from pain.[@CIT0017] Pain intensity scores were rated using a 0 (no pain) to 10 (worst imaginable pain) numeric rating scale. Categories of pain severity[@CIT0018] were determined from the worst pain intensity scores (ie, 1--4= mild pain, 5--6= moderate pain, and 7--10= severe pain). In addition to assessing pain intensity, location, and relief, the BPI allows a rapid self-assessment of the impact of pain on daily activities, considering two subdimensions (affect and activity) using 7 items (general


other people3.4 (2.8) Sleep4.6 (3.1) Enjoyment of life3.4 (2.9) Mean pain interference4.6 (1.1)**Pain relief (0--100%)**51.9 (30.0)**Pain severity (%)n=71^b^Percentage** Mild (1--4)1115.3 Moderate (5--6)2534.7 Severe (7--10)3548.6[^2]

Patient-reported pain management {#S0004-S2004}
--------------------------------

[Table 3](#T0003){ref-type="table"} presents patients' feelings concerning the management of their pain. As the main objective, the mean score for the 9 assessed items on this feeling on pain was 6.9 (SD, 1.3) of 10. More precisely, a good understanding and management of pain treatment were reported with a mean score of 7.8. The exploration of potential associations between patients' feeling about pain management and their feeling about pain highlighted that better understanding of treatment was positively statistically significantly related to 1) the feeling that there are solutions to relieve pain (*p*=0.005), 2) less sleep discomfort (*p*=0.03), and 3) better relief obtained with pain treatment (*p*=0.02). The mean scorebetween patients' expectations and needs. From an ethical point of view, the aim of the first step of a PEP, which is called the educational diagnosis or, more relevantly, the "shared educational assessment",[@CIT0026] is precisely to bring the patient's needs to light. The same applied to the role of relatives in the management of their pain. Issues involving relatives were less retained (ie, participation in pain management for 5.9%) and few patients sought aid from relatives for pain management (4.6/10). However, involvement in the patient's environment has been demonstrated to be very important for pain management.[@CIT0027] In this context, we plan to propose to patients to ask their relatives to participate in the further steps of our program, if they wish. Concerning the format of the educational sessions,


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Looks like appendItems() is a function in a subclass of UITableViewController. If that's the case, try the following. It's impossible to give an exact answer without knowing what your tableView(UITableView, numberOfRowsInSection: Int) and tableView(UITableView, cellForRowAt: IndexPath) look like. So this is based on the assumption that---
author:
- James Carlson and Domingo Toledo
date: 'April 9, 2011, revised October 2, 2011. Research partially supported by National Science Foundation Grant DMS-0600816; the first author also gratefully acknowledges the support of the Clay Mathematics Institute and of CIMAT.\'
title: Cubic Surfaces with Special Periods
---

Introduction
============

Consider a complex elliptic curve $E$ with equation $$\label{equation:weierstrass}
  y^2 =  4x^3 - g_2x -g_3.$$ The endomorphism ring of such a curve always contains the integer dilations $z \mapsto nz$. An elliptic curve with a larger endomorphism ring is said to have *complex multiplication*. The additional endomorphisms are of the form $z
\mapsto \lambda z$, and it is easy to see that $\lambda$ lies in a purely imaginary quadratic extension $K =
{{\mathbb Q}}(\sqrt{-d})$ of the rational numbers. This number field can be identified


= sum( sgn(tx) for tx in x.complex_embeddings() )
        return ( pos_minus_neg == 3 )

Finally, we enumerate the totally real quintic fields of discriminant less than N, applying the above test to each, and collecting various statistics.

      def testFields(N):

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        print "Number of totally real fields:", len(TRF)

        n = 1
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        ratio = 0;
 by their automorphism group *and* this group is generated by reflections. This suggests an easier sub-problem:

-   [*Find values of the period map for all surfaces with symmetries*]{} These surfaces are totally classified. One special family of such surfaces that should be more tractable is the following:

-   [*Find the values of the period map for all cyclic cubic surfaces. Express them as explicit functions of the periods of the corresponding cubic curves.*]{} A cyclic cubic surface means a surface $S\subset{{\mathbb P}}^3$ given by an equation $x_3^3 = f(x_0,x_1,x_2)$ where $f(x_0,x_1,x_2)$ is a non-singular cubic form, in other words, $S$ is the cyclic cover of ${{\mathbb P}}^2$ branched along the cubic curve $f=0$.

-   [*Study special values of the period map*]{}. We mean the situation


${{\mathcal P}}$, in spite of its transcendental definition, is an algebraic map. See [@Achter] for more information and for progress on this question.

[99]{}

J. Achter, Arithmetic Torelli maps for cubic surfaces and threefolds, arXiv:1005.2131v2 \[math.AG\], August 8, 2011.

D. Allcock, J. Carlson, and D. Toledo, The complex hyperbolic geometry of the moduli space of cubic surfaces [*J. Algebraic Geom*]{}. 11 (2002), 659-724. (math.AG/0007048)

D. Allcock and E. Freitag, Cubic surfaces and Borcherds products, Comment. Math. Helv. 77 (2002), 270Ð296.

A. Beauville, Moduli of cubic surfaces and Hodge theory (after Allcock, Carlson, Toledo), Géometries a corboure négtive ou nulle, Sémin. Congr. [**18**]{}, Soc. Mat. France, Paris, 2009, 445–466.

S. Lang, Complex Multiplication (Grundlehren der mathematischen Wissenschaften 255), Springer-Verlag 1983, pp. 185.

K. Matsumoto and T. Terasoma, Theta constants associated to cubic threefolds. J. Algebraic Geom.a comfortable position where his knees are bent and wide apart. A pillow should be between his feet. Then have the woman climb from behind the man, and wrap herself around him so that her head is on the pillow, her thighs on his shoulders, and her knees around his head. There are some women who swear by this position, as it forces all the blood to their head, thus increasing orgasm intensity, but it can be a challenging pose for both partners, especially in the middle of her thrashing about.

Supported Headstand

Take a thick blanket and fold it so that it’ll support the woman’s shoulders and neck – if she’s a yoga fan, she’ll know exactly what to do. Then have her put her shoulders along the longest


Tuesday Technology Thoughts – Protoyping IoT usecases

Though IoT become buzz word, there are few myths around it. I am making an effort to break those myths.
Before that, let me put down few thoughts – Which are not IOT. IoT is not just attaching sensors
IoT is not prediction and big data analytics
IoT is not connecting things
IoT is not automation

It is combination of all scenarios. So it is essential to make a prototype before the idea is built into industry standards. Steps involved:

Ideation

Prototyping

Proof of business

Industrialization

post production and support

Hence it is important to make prototypes to make one believe. There are few myths around making prototypes.

Consider an example :Usecase : When someone enters in the restricted zone, alarm lights should flash and hooter need to make alarm. Automated email and Appearned a wildcard berth. On January 9, 2011, Shields started in his first career playoff game and recorded four solo tackles and a pass deflection during a 21–16 victory at the Philadelphia Eagles in the NFC Wildcard Game. The Packers then defeated the Atlanta Falcons in the NFC Divisional Round. On January 23, 2011, Shields started in the NFC Championship game and recorded four solo tackles, deflected two passes, made two interceptions, a sack, and forced a fumble during a 21–14 win at the Chicago Bears. He intercepted a pass by quarterback Caleb Hanie, that was intended for wide receiver Johnny Knox, with less than 47 seconds left to seal the Packers' victory and send them to Super Bowl XLV. On February 6, 2011, Shields collected two solo


temple – overlooking fields scratched in and around Yale and its gargoyles.

To the west billowed the smoke and steam of the Generator district. To the south a pine forest grew below a great crystal dome. To the east stretched the sea... and on the horizon, the Black Building, a mirrored spire three miles high. Its auroras crackled even in the daytime, now.

City, all of it. City where there hadn't been any before. City that shouldn't have existed, parts of it fallen to rubble or rent by enormous claws, beautiful in its very state of dissolution, its struggles, its terrors. Mixed-vintage misery was the flavor of the day: not at all unpleasant, darkened by dread, textured by small annoyances and flashes of hate or pain. Even the abandoned stretcheshe asked.

"That's all. They're keeping the place?"

"Likely," said Istvan.

"Then we're leaving. They'll take care of the Shattered folks. Nothing we can do." The wizard walked faster. "You tried."

Istvan glanced back at Grace, who met his gaze. He shook his head. She shrugged in disgust, and turned to her men.

No more. No site. No progress.

Bloody Barrio Libertad. No trouble at all until the Susurration made its move, and now its people were everywhere, flaunting their superior equipment and their expertise in seemingly all things. The Twelfth Hour hadn't thought through the implications of freeing the largest settlement in Big East to pursue its own devices. Now it was as bad as the British.

Worse; the British queen had at least been human.

And Edmund... oh, Istvan had to work with them


the Susurration.

"All right?" asked Edmund.

Grace sighed. She patted at her pockets and withdrew another silvery vial, twisting at it as she kneeled. "He won't be if he wakes up here."

Clark peered into the cab. "Where's your friend? The ghost?"

Edmund's smile faded, despite himself. He glanced back at the horizon. No Istvan.

It had taken more than two hours to get back, and still no Istvan.

He couldn't have been hurt – Istvan was Istvan, after all – and he wouldn't have run off, no matter what he'd said about Triskelion and the fighting there and his worries about losing himself. Again. Like he'd done for decades before he was chained.

Edmund tried not to think about the flash of a knife in the dark, a forest littered with burning Russian tanks.whose control improved. In very few cases (≤5%), did we find that a significant increase in physical activity or counseling visit was documented at the visit when the decreased HbA1c level was observed. A single modification was given as a contributing factor of improved control for eleven (28%) patients, whereas 18 (46%) reported to have made more than one modifications prior to the visits with documented improved control. For the remaining 10 (26%) patients, no modification of the diabetes regimen was documented in the medical record.

**Predictors of Significant Improvement in Glycemic Control**

The final multiple logistic regression controlling for age, gender, race and insurance showed that the duration of persistent poor control and the mean HbA1c level were significant in predicting whether a persistently poorly controlled patient would subsequently


improve in glycemic control ([Table 4](#t4){ref-type="table"}). Each additional visit with HbA1c ≥10% and every one percentage point increase in the mean HbA1c level reduced the likelihood of subsequent improved control by 20% and 50%, respectively.

DISCUSSION
==========

Previous studies support our conclusions that older children tend to have more difficulty of diabetes control than younger children ([@ref12],[@ref13],[@ref14]). In addition, we were able to quantify the observation that, once glycemic control had deteriorated, this population was very likely to remain in poor control for extended periods of time. The reason for both observations appears to be similar. According to previous studies, the changing hormonal milieu of adolescents with T1DM, combined with decreased adherence, places them at risk for higher HbA1c levels ([@ref12],[@ref13]). The situation is often exacerbated by the fact that adolescentsare expected to assume increasing responsibility for their own diabetes care with subsequent decreased supervision by caregivers for blood glucose monitoring, insulin administration and dose adjustment ([@ref14]). If such issues persist, patients may have persistent poor control, despite efforts by the diabetes team to suggest strategies to reverse the poor control at clinic visits.

Moreover, we found that young females were more likely to be in persistent poor control than young males. Decreased insulin sensitivity that occurs during puberty, particularly in females ([@ref12],[@ref15],[@ref16]), and psychosocial factors, such as the level of adjustment to illness ([@ref17]), may play an additional role in sustained poor diabetes management. Eating disorders are also more prevalent in young females with T1DM than in those without T1DM ([@ref18],[@ref19]), and than in young males with T1DM


need to be spent at visits during which improvement in glycemic control is documented, in order to reinforce the changes in diabetes management that were responsible for the observed improvement, which may increase the likelihood that such improvement will be sustained.

###### Characteristics of the included patients (n=151)

![](JCRPE-4-82-g1)

###### Characteristics of the included patients in persistently poor glycemic control by the outcome variable (n=104)

![](JCRPE-4-82-g2)

###### Characteristics of the included patients in persistently poorglycemic control who subsequently improved (n=39)

![](JCRPE-4-82-g3)

###### Determinants of the likelihood of subsequent improved control inchildren with type 1 diabetes and persistently poor glycemic control, usingmultivariable logistic regression

![](JCRPE-4-82-g4)
or FITNESS FOR A PARTICULAR PURPOSE. See the GNU
 * Lesser General Public License for more details.
 *
 * You should have received a copy of the GNU Lesser General Public
 * License along with SU2. If not, see <http://www.gnu.org/licenses/>.
 */

#pragma once

#include "CDiscAdjFEAVariable.hpp"
#include "../../../Common/include/toolboxes/CVertexMap.hpp"

/*!
 * \class CDiscAdjFEABoundVariable
 * \brief Main class for defining the variables on the FEA boundaries for adjoint applications.
 * \ingroup Discrete_Adjoint
 * \author R. Sanchez.
 * \version 7.0.6 "Blackbird"
 */
class CDiscAdjFEABoundVariable final : public CDiscAdjFEAVariable {
private:

  MatrixType FlowTraction_Sens;        /*!< \brief Adjoint of the flow tractions. */
  MatrixType SourceTerm_DispAdjoint;   /*!< \brief Source term applied into the displacement


                                 adjoint coming from external solvers. */

  CVertexMap<unsigned> VertexMap;      /*!< \brief Object that controls accesses to the variables of this class. */

public:
  /*!
   * \overload
   * \param[in] disp - Pointer to the adjoint value (initialization value).
   * \param[in] vel - Pointer to the adjoint value (initialization value).
   * \param[in] accel - Pointer to the adjoint value (initialization value).
   * \param[in] npoint - Number of points/nodes/vertices in the domain.
   * \param[in] ndim - Number of dimensions of theDonald Trump. I have filed many thousands of words over the past decade on what I view as Doug Ford’s inadequacies as a politician, and it would never have occurred to me to compare him to such a transparently awful president.

Ford, too, has levelled many vastly over-the-top accusations against his opponents. But he has basically set them all aside now. While federal Conservatives continue battling federal Liberals on the carbon tax file, Ford has refused to discuss it and happily applauds the feds’ anti-coronavirus efforts. Where once Ford railed at his media critics, now he praises their efforts covering the crisis and informing Ontarians. His relatively plain talk is noticeably more reassuring than the messaging some other Canadian heads of government, who fancy themselves far more polished, are


Long-term treatment with resveratrol attenuates oxidative stress pro-inflammatory mediators and apoptosis in streptozotocin-nicotinamide-induced diabetic rats.
This study was designed to investigate the possible effectiveness of chronic resveratrol administration on redox state, inflammatory mediators and apoptosis rate in diabetic rats. Male Wistar rats were divided into four groups (n = 6): normal control, diabetic control, normal rats treated with resveratrol, and diabetic rats treated with resveratrol. Diabetes was induced by injection of streptozotocin (50 mg/kg; i.p.), 15 min after the prescription of nicotinamide (110 mg/kg; i.p.) in 12 h-fasted rats. Four-month oral resveratrol administration (5 mg/kg/day) significantly alleviated hyperglycemia, weight loss, enhancement of oxidative markers (lipid peroxidation index, nitrite/nitrate content and oxidized to reduced glutathione ratio) and superoxide dismutase activity in diabetic rats. Moreover, resveratrol administration to diabetic rats improvedstaff in the last six financial years. Some £348,378 was paid in non-consolidated bonuses, with a further £108,885 in “special bonuses”.

The details were obtained by the Belfast Telegraph after a Freedom of Information (FOI) request.

The Planning Service refused to reveal the identities of those who received a bonus because they regard it as “personal information”, which is exempt from disclosure under FOI.

The Planning Service is headed by chief executive Cynthia Smith. She, along with Marianne Fleming, director of corporate services; Anne Garvey, director of operations; and director of strategic planning, Tom Clarke, make up the agency’s top level management board. It is not known whether any of these four received bonuses.

Separate documents obtained by this newspaper reveal the total included £216,330 in bonuses paid to staff at six


have been given bonuses for not meeting targets,” he said.

The Planning Service was unable to provide details of the reasons why bonuses were awarded, or which officials had received payments. Last month’s PAC report found the planning applications system used by the Planning Service was “not fit for purpose”.

A spokesman for the Planning Service said the special bonus scheme rewarded “exceptional performance”.The Adoption Advocate is a publication created by NCFA to educate policymakers, families, child welfare specialists, and other interested parties on today's most relevant child welfare and adoption issues. This publication is edited by Christie Renick, Chuck Johnson, and Ryan Hanlon. You can sign up to receive the Adoption Advocate by email each month by signing up for our email list.

Posted December 1, 2014

Authored By: Kris Faasse, Sarah Horton Bobo, and Angela Magnuson

It's important to recognize that adoption is a lifelong experience, and acknowledge the challenges for many of those touched by it. In the December 2014 issue of NCFA's Adoption Advocate, authors Kris Faasse, Sarah Horton Bobo, and Angela Magnuson outline some of the ways that adoption service providers can help adoptees, adoptive family members, and birth


adoption process involves liability in multiple areas, including financial accountability, information disclosure, communication with clients, and the actions and supervision of employees. In the July 2014 issue of NCFA's Adoption Advocate, Michele Jackson explains the current requirements for licensed agencies for the benefit of both adoption service providers and prospective adoptive families.

Posted June 1, 2014

What are the Factors Leading to Broken Adoptions?

Authored By: Dawn J. Post

While broken adoptions represent only a small percentage of adoptions, it is crucial for adoption and child welfare advocates to study these cases in order to better understand the contributing factors and help prevent future broken adoptions. In the June 2014 issue of NCFA's Adoption Advocate, Dawn J. Post of the Children’s Law Center New York (CLCNY) describes the results of a six-monthus by clicking the arrow on the upper right side of the comment and selecting "Flag comment as inappropriate". If you've recently registered with Disqus or aren't seeing your comments immediately, you may need to verify your email address. To do so, visit disqus.com/account. See more about comments here.


cells. Significant intracellular changes in bacteria were remarkably noticed through different membrane permeabilization assays. The rate of Na+ and K+ leakage with respect to time, intracellular material and cytoplasmic β-galactosidase release were measured spectroscopically. The results indisputably prove that membrane disruption of S. aureus cells occurs within 2 h and in E.coli occurs in between 2 and 4 h of exposure. Crude extract of P. setosum was fractioned using semi-preparative HPLC and the separated antibacterial active fraction showed antibacterial efficacy with the minimum inhibitory concentration of 8 μg/mL against both organisms. Active fraction contains four well-known plant metabolite belongs to the polyphenolic group (Leucodelphinidin, dihydroquercetin, kaempferol, and quercetin) and one polyketide (patulin) familiar as fungal metabolite, identified through high resolution LC-MS. Interaction mechanisms of identified compounds with nineboth caused cell-cycle arrest in the G2-M phase, (ii) showed similar degrees of apoptosis induction (cleaved caspase), and (iii) had similar IC50 values when compared with paclitaxel in MTT assay. A preclinical model of brain metastases of breast cancer using intracardiac injections of Luc-2 transfected MDA-MB-231Br cells was used to evaluate in vivo efficacy of the nanoconjugate. The animals administered with HA-paclitaxel nanoconjugate had significantly longer overall survival compared with the control and the paclitaxel-treated group (P < 0.05). This study suggests that the small molecular weight HA-paclitaxel nanoconjugates can improve standard chemotherapeutic drug efficacy in a preclinical model of brain metastases of breast cancer.


in your PATH environment
  variable.

I just recently used this recommendations and it went down pretty smoothly. I installed forever globally (since it is a command line tool) and all my application modules locally.
However, if you want to use some modules globally (i.e. express or mongodb), take this advice (also taken from blog.nodejs.org):

Of course, there are some cases where
  you want to do both. Coffee-script and
  Express both are good examples of apps
  that have a command line interface, as
  well as a library. In those cases, you
  can do one of the following:

Install it in both places. Seriously, are you that short on disk
  space? It’s fine, really. They’re tiny
  JavaScript programs.
Install it globally, and then npm link coffee-script orescalation of the dose if needed depending on the level of the PRL and tumor size. If PRL levels normalized, and a significant reduction in tumor volume of greater than 50% from the previous imaging was achieved, CAB doses were maintained or decreased to the lowest possible dose.

All patients were followed for a mean period of 6.3 years (range 2-13 years). Follow-up clinical visits included a clinical examination focusing on visual field examination, assessment of the PRL level, pituitary function tests, and MRI.

Definition of response to therapy {#section13-1179551420926181}
---------------------------------

Hormonal response or remission was defined as serum PRL measurement, either lesser than or equal to 390 nmol/L (⩽25 ng/mL) or more than 50% reduction from the baseline with at least 12 months of follow-up from the time of initial clinical visit. Similarly, the radiological response


was defined as no evidence of visible tumor or more than 50% reduction of tumor from the baseline on the follow-up MRI.

Statistical analysis {#section14-1179551420926181}
--------------------

Results are expressed as mean ± SD for continuous variables and percentages (%) for frequencies. Data were analyzed using SPSS version 16.5 (SPSS Chicago, IL, USA). Differences in a patient, PRL, or tumor-related parameters by time to treatment response were calculated with Student's unpaired t-test. A *P*-value lesser than .05 was considered significant.

Result {#section15-1179551420926181}
======

Among 286 patients with pituitary tumors, we observed 33 cases (11.5%) which fulfilled the clinical and radiological criteria of giant prolactinomas during the study period, and these were included in our study. Among this group, 24 were men with an age range of 20 to 63 years (mean 38.13 years) at diagnosis and 9 were womenwith an age range of 18 to 52 years (mean 34.78 years) at diagnosis. There were more men with giant prolactinomas (24 vs 9) with a larger baseline mean diameter (4.29 cm vs 4.02 cm), greater mean baseline volume (49.88 cm^3^ vs 24.17 cm^3^, *P* = .0958) and smaller posttreatment mean diameter (1.5 vs 1.99 cm^3^, *P* = .05) compared with female patients. Other comparisons between sexes were not statistically significant.

The mean serum PRL concentration at the time of diagnosis ([Table 1](#table1-1179551420926181){ref-type="table"}) was extremely high 95 615.03 nmol/L (range 10 000-42 5325 nmol/L). The latest PRL level was dramatically reduced in all patients, with a mean PRL change of 95.41% (range 77.77-99.99%). Baseline and posttreatment mean values of PRL and tumor volume are tabulated in [Table 1](#table1-1179551420926181){ref-type="table"}.

######

Baseline and posttreatment mean values of prolactin and tumor volume.

![](10.1177_1179551420926181-table1)

  Data


   1 (9.09)
  Pituitary apoplexy   5 (16.13)   4 (16.67)     1 (9.09)

Abbreviation: CSF, cerebrospinal fluid.

Overall response to therapy {#section18-1179551420926181}
---------------------------

CAB served as the primary therapy for all the patients in this study. The median follow-up period was 6 years. Remission, after medical treatment was achieved in all but 5 patients, were treated with second-line treatment modalities (surgery/radiation). Cumulative remission after all the treatment modalities was achieved in 97% of the patients.

Overall, 5 patients needed surgical interventions. Three patients underwent partial trans-sphenoidal resection of the tumor either due to apoplexy, mass effect, nasal obstruction, resistance to medical therapy, or CSF leak. Two patients underwent transcranial partial resection for apoplexy and hydrocephalus. ([Table 5](#table5-1179551420926181){ref-type="table"}).

######

Treatment modalities of patients with giant prolactinomas.

![](10.1177_1179551420926181-table5)

 in 33.3% of patients and significantly decreasing (\>90%) from baseline value in 66.7% of patients. Tumor volume also decreased by an average of 92% for men and 80.4% for women. A recent review of 7 series^[@bibr5-1179551420926181]^ of a total of 49 patients with giant prolactinomas treated with bromocriptine (BRC) (n = 35) or CAB (n = 14), the rate of PRL normalization was 65% with 64% of patients experiencing at least 50% reduction in tumor size. In the remaining patients, around 95% PRL reduction was achieved. In a series^[@bibr21-1179551420926181]^ of 10 giant prolactinomas in men, treated with CAB serum PRL decreased by 96% from the baseline with persistent normalization achieved in 50% of patients within 3 to 6 months of treatment (mean duration of treatment 38.9 months). Tumor shrinkage was achieved after 12 months in


fishing because my Dad taught me how to fish. He took my sister and me to different lakes and parks near our house when I was growing up, and we also went fishing in my grandparent’s pond in southern Illinois, which was always stocked with well-fed (i.e., gigantic!) catfish.

But I’m kind of impatient when it comes to fishing – there’s not a lot of zen in it for me. I practice catch-and-release because I don’t like killing things, but then I feel guilty because I’m just playing with the poor thing instead catching it to eat. Soooo not logical.

We wanted to go fishing in Fort Snelling State Park because you don’t need an angling license for MN state parks. I had heard of Fort Snelling State Park, butfull day left of the weekend. I’d call this another successful Saturday.

Last weekend was incredible – I’m just starting to recover! Let me tell you what I did…

On Friday night, I went to the first classroom session of my SCUBA class! The class took place in a teensy, tiny 9-chair classroom in the basement of the Minneapolis Scuba Center. The lessons were brief. They were very much a high level review of the textbook, so it’s a good thing I actually did all of the assigned reading and in-book quizzes and tests.

After I got back from class at 10pm, the Hubby and I went walking through LynLake and Uptown. It was an excellent spring evening, and the crowds were out! The yuppies were dolled up and standing on


is diminished. Their underestimate of the impact of their policy change on prices, their indifference vis-à-vis the financial damage to other OPEC members, and their willingness to take market share at the expense of other OPEC members undercut their credibility within OPEC (particularly since it derived from Saudi willingness to protect the interests of all members (and sometimes to endure disproportionately).

While Saudi financial reserves are substantial (circa $672 billion in May), drawing on them is little more than a stop-gap measure. If its major competitors (Russia, Iraq, Iran, and North America) maintain or even increase output (and they have the incentive to do so), prices could stay lower far longer than the Saudis anticipated. Saudi reserves have decreased some $65 billion since prices started to fall (in November),of the combine where it is discharged. The sieved “clean” grain is directed toward and is collected at the bottom of the clean grain elevator 22. The clean grain elevator 22 lifts the collected clean grain upward into a discharge area 24. An auger 26 within the discharge area 24 carries the grain into a holding tank or hopper 28. As the hopper 28 begins to fill, the grain is unloaded as needed by the unloading auger 30 into a waiting grain cart, wagon, truck or other transport (not shown).
Referring to FIGS. 1 and 2, the clean grain elevator 22 is disposed within a housing 32 and is comprised of a chain 34 which passes around upper and lower sprockets 36, 38. A plurality of equally spaced flights


A taxonomy of endogenous and exogenous uncertainty in high-risk, high-impact contexts.
By reference to a live hostage negotiation exercise, this study presents a taxonomy of uncertainty that can be usefully applied to assist in the categorization and application of findings from decision-making research conducted in naturalistic (specifically critical incident) settings. Uncertainty was measured via observational methods (during the exercise and by reference to video footage), decision logs, and postincident simulated recall interviews with trainee police officers. Transcripts were coded and analyzed thematically. Uncertainty was dichotomized as deriving from either endogenous sources (about the problem situation itself) or exogenous sources (about the operating system that is dealing with the incident). Overall, exogenous uncertainty (75%) was more prevalent than endogenous uncertainty (25%), specifically during discussions on plan formulation and execution. Itmicrofilaments and microtubules, which are found experimentally to control shape change in cells. Special attention is paid to the conditions that a thermodynamically consistent formulation should satisfy. The model is used to simulate the multicellular shape changes observed during ventral furrow invagination of the Drosophila melanogaster embryo. The results confirm that ventral furrow invagination can be achieved through stress control alone, without the need for other regulatory or signalling mechanisms. The model also reveals that the yolk plays a distinct role in the process, which is different to its role during invagination with externally imposed strains. In stress control, the incompressibility constraint of the yolk leads, via feedback, to the generation of a pressure in the ventral zone of the epithelium that eventually eases its rise and internalisation.


Day trip to Catania

It’s only about 3 p.m. here* at the moment, but I’m already feeling like this was a great day. And like I’m a total badass, because I drove in Catania.

So, to back up we finally decided last night that we should check out Catania, the biggest city near us. We’ve been putting it off because whenever you read about driving there, the main advice is “don’t.”

With almost a month in Sicily under our belts, however, we decided that we might as well try. And I’m so glad we did – I liked it way more than I expected! I had fairly low expectations, but it was really a cool city.

So, the driving was ridiculous but didn’t end up being too dramatic. Fortunately, Chris drove therehope so.

The place was amazingly busy, and I actually do wish that we were in our house so that it would have made sense for us to buy some meat, cheese, fish, etc. In the future, for sure! We did pick up some strawberries and small berries that looked like a cross between strawberries and raspberries (not sure of the name). Fiona destroyed them while Chris and I had a couple of cappuccinos, starting by taking a single large bite out of each one. Once she ran out, she went back to finish them off. Owen was scarfing down the little berries in the meantime, albeit not at quite the same rate.

The view from our cafe

While we were waiting for a bill for the coffee, the kids wanted


to “speculate” on what a final interest rate may be during a media briefing on the proposal, but the administration previously floated a 5 percent estimate. That would bring the total cost to roughly $4.7 billion.

The General Assembly will return from its summer recess in September. Bills authorizing Restore PA were introduced in June with majority support in the Senate and near-majority support in the House.

But neither piece of legislation can advance without the cooperation of Republican leadership.

Senate leadership did bring a severance tax proposal up for a vote in 2017, albeit with weakened environmental regulations. It passed 26-24, but was not considered in the House.

Indeed, the lower chamber seems much less likely to bend. The House Environmental Resource & Energy Committee is chaired by Rep. Daryl Metcalfe,called the attack a "major escalation", and reiterated in what sounded to us like a thinly veiled threat that Saudi Arabia has the capacity to protect its vital institutions.

You may remember that the Houthis have over the last year repeatedly fired missiles (with mixed success) at Saudi oil fields and even came close to successfully bombing a royal palace.

Earlier, over in the UK, a spokesperson for the government called the attack on civilian oil tankers "completely unacceptable" and said the UK was ready to assist in the rescue effort and investigation.

Meanwhile, senior officials from the US and UAE have attributed the attack to a "state actor," though they neglected to explicitly name Iran.

All this is happening before the investigation into the attacks has even begun. And BBG's Javier


Q:

How to show the units of $\mathbb{Z}[\sqrt{-5}]$ are 1 or -1 using a norm map.

I am trying to show that, using the norm map $N : \mathbb{Z}[\sqrt{-5}] \to \mathbb{Z}$ defined by:
$N(x+y\sqrt{-5}) = (x+y\sqrt{-5})(x-y\sqrt{-5}) = x^2 + 5y^2$, the units in $\mathbb{Z}[\sqrt{-5}]$ are $\pm$1.
I am unsure how to proceed but am thinking that the $x^2 + 5y^2$ will have to be equal to $\pm$1 as this will form a unit circle, is this right?
Thanks for the help.

A:

Let $a\in\mathbb{Z}\left[\sqrt{D}\right]$. Then $a$ is a unit iff $N\left(a\right)=\pm1$.

To prove this, remember that $N\left(ab\right)=N\left(a\right)N\left(b\right)$. Thus, if $a|b$ also $N\left(a\right)|N\left(b\right)$. A unit $a$ satisfies both $1|a$ and $a|1$ and therefore $N\left(1\right)|N\left(a\right)$ and $N\left(a\right)|N\left(1\right)$. But $N\left(1\right)=1$ and this happens in $\mathbb{Z}$, forcing $N\left(a\right)=\pm 1$. The other direction follows immediately from the factmarkers.

II.. MATERIALS AND METHODS {#acm20071-sec-0002}
==========================

A.. Monte Carlo simulation {#acm20071-sec-0003}
--------------------------

A 6 MV photon beam delivered from the Vero4DRT system was simulated using the BEAMnrc accelerator, and DOSXYZnrc codes.[^14^](#acm20071-bib-0014){ref-type="ref"}, [^15^](#acm20071-bib-0015){ref-type="ref"} The linear accelerator head in the Vero4DRT system was simulated using the BEAMnrc code. The modeled linear accelerator head is composed of a compact C‐band 6 MV accelerator tube, a target, a primary collimator, a flattening filter, a monitor chamber, fixed secondary collimators, and a multileaf collimator. The description of the linear accelerator, such as the geometries and the materials of each component, were provided by the manufacturer.[^(16)^](#acm20071-bib-0016){ref-type="ref"}

The field size was set to $5.0 \times 5.0\text{cm}^{2}$. The simulation time was 40 hours on a PC having an Intel Xeon Quad Core 2.4 GHz with 16 GB memory. For the transport


optimization of ^13^C-labeled carbon sources depends on the metabolic flux distribution inside of the target cells, a factor that is usually unknown before a ^13^C-MFA experiment. Furthermore, the relationship between precision of flux estimations, composition of \[^13^C\]glucose (tracers) and the metabolic flux distribution remains unclear. Thus, the best first choice of a ^13^C-labeled carbon source for the precise estimation of any given flux distribution in the whole metabolic network is also unclear. Recent optimization efforts via the analysis of experimental data or computer simulation of ^13^C-MFA experiments revealed that \[4,5,6-^13^C\]glucose and the mixture of \[1-^13^C\] and \[U-^13^C\]glucose at a ratio of 8:2 are suitable for the flux determinations of the TCA cycle and the pentose phosphate pathway, respectively ([@bib13], [@bib23], [@bib30]). Further investigation considering the other flux distributionsreported flux distributions of *E. coli* to investigate the relationship between the precision of metabolic flux estimation, composition of \[^13^C\]glucose and the metabolic flux distribution, from which compositions of useful \[^13^C\]glucose were discussed. The results showed that \[1,2-^13^C\]glucose and the mixture of \[1-^13^C\] and \[U-^13^C\]glucose at 8:2 are the most useful first choices for a precise estimation of flux level, whereas the anaplerotic and glyoxylate pathway reactions are affected by both the carbon source and flux distribution. The simulation results were confirmed experimentally by ^13^C-MFA of *E. coli*.

2. Materials and methods {#s0010}
========================

2.1. Software {#s0015}
-------------

All procedures for the simulation of ^13^C-MFA experiments were performed using a Python version of OpenMebius ([@bib20]) implemented in Python 2.7.9 with NumPy 1.9.1, SciPy 0.4.2, PyOpt 1.2, and parallel Python 1.6.4 modules. Metabolic fluxes


(1901-1988).

Originally from London, Hayter started out his career in the oil industry after earning his degrees in chemistry and geology. From 1922 to 1925, he worked for the Anglo-Persian Oil Company in Iran, until a bout with malaria forced him to return home. During this time of convalescence, he had a successful one-man show of his paintings and drawings, which may have inspired him to pursue a more artistic calling. Although he soon switched over to art, his chemical background would undoubtedly influence his later printmaking.

In 1926, Hayter went to study at the Academie Julian in Paris, and opened his own printmaking atelier, Atelier 17, in 1927. It was also during this time that he was introduced to Surrealism, particularly as interpreted by artists such as Yves TanguyTag: hanging high school the nonsense bearer s pupil

Hanging High Chair How To Design Your Home Office For Under $500, Being of an smaller stature, I had never really thought a long time and too hard with what it absolutely was like for folks of larger stature. Of course that is not to convey I am closed minded. I’m just stating that sometimes […]


in the Football League Third Division South. He was released by the "Valiants" at the end of the 1947–48 season by manager Gordon Hodgson. Shore moved on to Coventry City. He played two Second Division games in 1948–49 and 1949–50, before "Sky Blues" manager Harry Storer allowed him a move away from Highfield Road. He later played non-league football for Hinckley Athletic.

Statistics
Source:

References

Category:1927 births
Category:1976 deaths
Category:Sportspeople from Nuneaton
Category:English footballers
Category:Association football midfielders
Category:Port Vale F.C. players
Category:Coventry City F.C. players
Category:Hinckley United F.C. players
Category:English Football League playerswere denying access to a page. However, a 403 code does not necessarily mean the content is censored in a certain location. It could be blocked to everyone for security reasons, for instance.

With the approval of the 451 code, it is now easier for websites to identify content that is specifically censored. Companies like Twitter can use the code to indicate to users that certain pages have been blocked by government authorities in a particular country, even though they are available elsewhere.

With that information, users would know that they could use a VPN or Tor to access the censored content.

Code 451 — which, by the way, is a reference to Ray Bradbury’s novel Fahrenheit 451 — is also useful because it makes it easier to identify censored websites


server issues, we migrated to a new host and have experienced ZERO errors. Also - know that the Site Backup Pro service is BROKEN, and does not allow you access to the back-ups that are included in the hosting plan. Support was more than willing to restore the back-ups for me, but REFUSED to give me copies, despite me providing multiple instances of documentation where I was promised and encouraged to download them to my computer. Probably because they knew I would be using the back-ups to escape their clutches. Other than that, Support is incompetent. SSL is buggy. Prepare for errors to pop up out of the blue. Beware Bluehost.
Other agents handled many other problems of similar difficulty with no sweat. In terms of human contact, BlueHostthe contact information listed in the whois database will be Bluehost. You will still be the owner of the domain name, but your contact details will not be accessible through the public whois information.
I have used Bluehost for over 12 months and have been very happy with the service they provide. For the money you get extremely good value – I host over 10 sites on the one account and have never had any problems with being told that I have gone over resource limits or used too much bandwidth. I have only needed to contact support a few times and they were always very quick to respond and help solve the issues, although it has to be said they were quite simple problems.
In July 2013, I said