group included 17 patients with H7N9-induced ARDS with allogenic menstrual blood-derived MSC transplantation. Results showed that the treatment group had a significantly lower mortality rate compared to the control group. The study also reported that MSC transplantation did not result in harmful effects in human body within the 5-years follow-up period. MSC transplantation significantly improved survival rate of H7N9-induced ARDS patients in both preclinical and clinical studies \[[@CR32]\]. Considering that H7N9 and coronavirus share similar complications such as ARDS and corresponding multi-organ failure, MSC-based therapy could be a potential alternative for mitigating COVID-19 \[[@CR32]\].

Another known and safe source of MSCs is Adipose tissue. Adipose-derived stem cells (ASCs) expresses a large amount of anti-inflammatory properties and can be obtained from a minimally invasive aspiration procedure \[[@CR33]\]. ASCs secret factorsand the Middle East respiratory syndrome coronavirus have been known to induce acute liver injury (ALI). Studies have shown that patients with COVID-19 ALI have an incidence rate as high as 11%. ALI induced by viruses can progress rapidly to acute liver failure (ALF) \[[@CR38]\]. ALI involves the infiltration of immune cells such as T cells, B cells and natural killer cells (NK). Immunosuppressive treatments and decreased inflammation reportedly promote repair after ALI \[[@CR38]\]. MSCs have shown a ray of hope in repairing and regenerating liver tissues and in treatment of liver diseases \[[@CR9]\].

A preclinical study demonstrated that ALI was significantly alleviated and survival rate of mice was improved post-treatment with MSCs. The results indicated that the MSCs modulated the hepatic immune system in terms of the distribution


properties, anti-inflammatory properties, etc.\[[@CR43]\]. Although exosomes have been discovered almost 30 years ago, it is only recently that scientists have generated immense interest for being one of the most promising, acellular alternatives to cellular therapeutics, due to their demonstrated aptitude \[[@CR43]\]. Exosomes were first identified to be secreted from nanovesicles of sheep reticulocytes, at the time of their maturation; the experiment was performed in the year 1980, soon after which, exosomes were studied rapidly, as the secretions of all the cells including immune cells, like B and T lymphocytes and are found to be necessary for cellular communications \[[@CR44]\]. Typically, exosomes are of the size of 40-150 nm and are found to be secreted through inward budding of the endosomes. Once released by the cells, they get entry into anothercellular microenvironment, by fusing to the plasma membrane \[[@CR45]\].

Studies have further indicated that increased cellular interaction, through cell to cell communication, is one of the most unique functions of exosomes \[[@CR45]\]. Other than that, disposal of unwanted proteins, transfer of genetic material, elicitation of the immune response, reduction in inflammation, etc. are also identified to be some of the functional attributes of exosomes, depending upon the cell of origin \[[@CR44], [@CR45]\].

Role of exosomes in COVID 19 infections {#Sec7}
---------------------------------------

Majority of the studies focusing on MSC-derived exosomes have demonstrated regenerative potential, immune-modulatory functions, anti-inflammatory effects, similar to their parents, i.e. Mesenchymal stem cells \[[@CR44], [@CR45]\]. In preclinical set up, MSC-derived exosomes have demonstrated aptitude as an acellular alternative to cell-based therapy, against Acute Respiratory Distress Syndrome (ARDS) \[[@CR46]\]. These studies


law against crime; they denounce the "plutocracy" but are fine with being financed by plutocrats; and they engage in politics in order to destroy politics. Such elements are absent from most non-fascist political movements, be them conservative, liberal, or - and here we can point to your question - socialist. Those either seek to restore old orders or maintain the existing one through instruments compatible with that order, or to destroy the existing order altogether; only fascists seek to restore an older order through - what they call - a revolution.
[1] When it comes to ideas and ideology, historically all fascisms have depended heavily on nationalism, sexism, and a cult of abstract violence (violence is good in itself, not as an instrument to attain a given goal, butto become an artist" on the "slab roll," for he had "all the earmarks of a comer." He even handled the bat fairly well, going 3-for-3 in one exhibition game against the University of Tennessee ballclub, and he appears to have played one inning -- the bottom of the eighth -- in right field during a game in Brooklyn later in the season.

But when Lake's club broke camp in April, Burke was shipped off to Montreal in the International League. He wasn't there long, earning a recall to the Doves and making his debut on April 30, 1910, against Brooklyn. In all, he would appear in 19 games for the Boston Nationals that year, starting one of them and mopping up to complete 16 others. He earned one


as among the best players in the Eastern League that year, and Burke finished with 16 wins. At the end of August, he was recalled to Boston.

Burke's Major League career lasted all of 21 games, just two of them starts. On Dec. 12, 1911, Burke was released again to Montreal, where he pitched in '12 and '13 before giving up the game at 24. Other than a few scattered photographs that have popped up -- whether on his Baseball-Reference profile or in some online archives of the Reach or Spaulding guides -- there is not much to represent Billy Burke's professional career. And so I thought I would piece it together for the record, presenting a game log of his 19 appearances for the Boston National League club.

Boston,interfaces, memory units, I/O controllers, and external crossbar interfaces all interconnected via a central data path (“CDP”). Internal signals from these units are collected on a performance monitor bus (“PMB”). One or more specialized performance counters, or performance monitors, are connected to the PMB and are useful in collecting data from the PMB for use in debugging and assessing the performance of the system of which the CC is a part. Currently, each of the performance counters is capable of collecting data from only one preselected portion of the PMB, such that the combination of all of the performance counters together can collect all of the data on the PMB. While this arrangement is useful in some situations, there are many situations in which it would be advantageous


"Yes, I see it." "It's exactly the same as the cipher." "WATSON CLEARS THROAT" "It's an ancient number system - Hang Zhou." "These days only street traders use it." "Those were numbers written on the wall at the bank and at the library." "Numbers written in an ancient Chinese dialect." "It's a 15." "What we thought was the artist's tag, it's a number 15." "And the blindfold, the horizontal line." "That was a number as well." "The Chinese number one, John." "We found it." "Two men travel back from China, both head straight for the Lucky Cat emporium." "What did they see?" "It's not what they saw." "It's what they both brought back in those suitcases." "And you don't mean duty free." "Thank you." "Think about what Sebastianoutside with crates of books." "So the numbers are references." "To books." "To specific pages and specific words on those pages." "Right, so... 15 and 1, that means?" "Turn to page 15 and it's the first word you read." "OK, so what's the message?" "Depends on the book." "That's the cunning of the book code." "It has to be one that they both own." "OK, fine." "This shouldn't take too long, should it(?" ")" "We found these...at the museum." "Is this your writing?" "Er, we hoped Soo Lin could decipher it for us." "Ta." "Anything else I can do?" "To assist you, I mean." "Some silence right now would be marvellous." "Cigarette." "Imagine." "CLOCK TICKS" "WATCH BLEEPS" "Oh..." "CHURCH BELLS RING" "I'm sorry to keep you waiting, but


hideout." "Hang on." "A hairpin worth 9 million?" "Apparently." "Why so much?" "Depends who owned it." "Two operatives based in London." "They travel over to Dalian to smuggle those vases." "One of them helps himself to something, a little hairpin." "Worth 9 million." "Eddie Van Coon was the thief, he stole the treasure when he was in China." "How do you know it was Van Coon, not Lukis?" "Even the killer didn't know that." "Because of the soap." "PHONE RINGS" "Amanda?" "HOLMES:" "He brought you a present." "Oh, hello." "A little gift when he came back from China." "How do you know that?" "You weren't just his PA, were you?" "Someone's been gossiping." "No." "Then I don't understand why..." "Scented hand soap in his apartment." "300ml of it."---
author:
- 'M. M. Schulreich'
- 'D. Breitschwerdt'
- 'J. Feige'
- 'C. Dettbarn'
bibliography:
- 'LBI.bib'
date: 'Received / Accepted'
subtitle: 'I.  transport to the solar system by turbulent mixing of ejecta from nearby supernovae into a locally homogeneous interstellar medium'
title: Numerical studies on the link between radioisotopic signatures on Earth and the formation of the Local Bubble
---

Introduction {#ch:intro}
============

Our solar system resides in a low-density region of the interstellar medium (ISM), partially filled with hot, soft X-ray emitting plasma, known as the Local Bubble (LB). While the existence of this superbubble (SB) is widely accepted today, not least because it was found to be responsible for about 60% of the $1/4$-keV flux in the Galactic plane [@Gal:14], its exact origin is still a matter of ongoing debate. The LB extends roughly $\unit[200]{pc}$ in the Galactic plane, and $\unit[600]{pc}$ perpendicular


divided into three classes according to their box size (and the highest resolution associated with it): small-scale [@Bal:04; @Pio:07], meso-scale [@Avi:04; @Avi:05; @Sly:05; @Gre:08a; @Jou:09; @Gir:15], and large-scale [@Han:09; @Dob:11]. A physically realistic three-dimensional model that covers all dynamical ranges of an entire galaxy is still out of reach, though there are efforts to achieve this to some degree by coupling the adaptive mesh refinement (AMR) technique with zoom-ins to specific regions [see e.g. @Ren:13 and follow-up studies].

Taking their modelled ISM as a typical background medium, [@Bre:06] further tested the aforementioned LB formation scenario under more realistic conditions. They found that the bubble’s extension, as well as its ion column density ratios [see @Avi:09; @Avi:12], matched ultraviolet data, as obtained e.g. with FUSE [@Oeg:05; @Sav:06], remarkably well.

Another interesting waySN event, whose blast wave takes only little time to move through the hot and thin pre-stratified medium. However, the situation is completely different for a single SN, or the very first one in a series, whose blast wave must penetrate through a totally inhomogeneous ISM and thus would soon undergo strong distortions. By the same token, the density distribution of the ambient medium has to be either homogeneous or obey a power law, implying that possible dense obstacles are not taken into account. This includes the LB’s outer shell, which was neglected in the preliminarily work by [@Fei:10], but was later implemented as a [@Wea:77] wind bubble for the improved analytical study contained in @Bre:16 [hereafter BFS+]. Second, the external medium is taken to be constant over


initial masses $M$, $$\frac{\mathrm{d}\mathcal{N}}{\mathrm{d}M}=\left. \frac{\mathrm{d}\mathcal{N}}{\mathrm{d}M}\right\vert_{0}M^{\Gamma-1}\,,
\label{eq:massey}$$ where $\Gamma=-1.1\pm 0.1$ [@Mas:95; @Ber:02; @Fuc:06]. With the lower and upper limit of the relevant mass range being defined by A0 and B0 stars, respectively (i.e. $M_{\mathrm{l}}=\unit[2.6]{M_{\sun}}$ and $M_{\mathrm{u}}=\unit[8.2]{M_{\sun}}$), we obtained the normalisation constant via integration of Eq. (\[eq:massey\]); $$\begin{split}
\left. \frac{\mathrm{d}\mathcal{N}}{\mathrm{d}M}\right\vert_{0}&=\mathcal{N}\left[\int_{2.6}^{8.2}M^{-2.1}\,\mathrm{d}M\right]^{-1}\\
& = 80\left[\frac{2.6^{-1.1}-8.2^{-1.1}}{1.1}\right]^{-1}= 351\,.
\end{split}$$

The lifespan of the first and most massive star that exploded in Loop I might be expressed as $$\tau_{M_{t'}}=\tau_\mathrm{u}-t'\,,
\label{eq:taumdeltatau}$$ where $\tau_\mathrm{u}$ is the lifetime of a star of mass $M_\mathrm{u}$ and $t'$ is the time at which the association entered the present volume of Loop I. When quantifying the main sequence lifetime of stars in the mass range $2\le M\le \unit[67]{M_\sun}$ by a fit to the isochrone data of [@Sch:92], $$\tau=\tau_0 M^{-\beta}\,,
\label{eq:mslifetime}$$ where $\tau_0=\unit[1.6\times 10^8]{yr}$ and $\beta=0.932$ [@Fuc:06], Eq. (\[eq:taumdeltatau\]) translates into $$M_{t'}=\left(M_\mathrm{u}^{-\beta}-\frac{t'}{\tau_{0}} \right)^{-1/\beta}\,.$$ Asfraction, $\vec{u}$ the fluid velocity, and $\alpha$ the diffusivity of the contaminant (which is assumed here to be isotropic). Since for the case of the ISM the Peclet number, $\mathrm{Pe}=UL/\alpha$, is large ($U$ and $L$ denote characteristic velocity and length scales), diffusive effects are restricted to the very small, so-called microscale of turbulence. At larger scales, the right-hand side of Eq. (\[eq:Zadvdiff\]) can hence be neglected. The scalar $Z$ then acts like a marker that tags the chemically enriched fluid parcels. However, there is still a need for some diffusive process ultimately operating at small scales, even though its exact value is quite insignificant for the turbulent mixing at the larger scales, as demonstrated by [@Avi:02] in ISM simulations with different resolutions. Like them we did not implement any


the survival fraction.

Specifically, $f$ denotes the fraction of atoms that reaches the Earth’s orbit after overcoming a variety of filtering processes, while being condensed into dust grains. After estimating the dust condensation of at departure from source, as well as its destruction through interstellar passage, heliosphere, and solar radiation pressure, [@Fry:15] concluded that $f\simeq 0.01$.

The other, so-called uptake factor, $U$, accounts for the fact that only a certain fraction of spread over Earth’s surface actually finds its way into the FeMn crust. The underlying chemical selection process is only poorly understood, implying that the value of $U$ is, as of $f$, very uncertain. [@Kni:04] quantified $U$ using the relative concentrations of iron and manganese in water and the FeMn crust, and the uptake of manganese (4%), while implicitlyanti-centre region of the Galactic plane. These clouds, which also possess non-negligible vertical extensions, are known to be part of Gould’s belt. Moreover, there is a 500–$\unit[1000]{pc}$ wide cavity in the third quadrant, as well as a small, elongated cavity in the opposite direction. The larger cavity is centred below the Galactic plane and was identified as the counterpart of the so-called GSH 238+00+09 supershell, which is visible in radio wavelengths [see @Pus:14 and references therein]. Assuming that these structures were present in a similar fashion as observed today throughout the entire evolution time, the LB’s outer shell would probably have experienced early on a greater ‘resistance’ in the second, fourth, and (partly) the first quadrant, and would thus not have grown to such a great extent in


models, i.e. the quite broad peaks of intermediate amplitude already known from Fig. \[im:fluence\_tot\_AB\], are produced when the LB’s supershell runs over the solar system. Separated from the shocked ambient medium by a contact discontinuity, the shell harbours a large amount of atoms that have by then been expelled in previous SN events (SNe \#01–08 and \#01–15 in model A and B, respectively) and that have not yet decayed (see also the inlays of Fig. \[im:fluence\_AB\]). Since the supershell of model B arrives later at the Earth’s orbit, it could already accumulate more SN ejecta (and thus enriched material), which is the reason why the profile of the total local interstellar fluence (Fig. \[im:fluence\_tot\_AB\]) has a first signal that is both broader and higher than in model A. Also note that thehours if the milk was refrigerated in good conditions, namely at a maximum temperature of 4°C [24](#apa14259-bib-0024){ref-type="ref"}. Both raw and pasteurised, human milk has been shown to inhibit bacterial growth and this inhibition was greater in raw (95%) than pasteurised human milk (80%) [47](#apa14259-bib-0047){ref-type="ref"}. This effect was reported both in human milk from mother who delivered at term or prematurely and whatever the germs [47](#apa14259-bib-0047){ref-type="ref"}. Human milk is routinely fortified in advance and refrigerated before its administration to hospitalised infants. Time is required to put human milk in bottles or syringes for all hospitalised infants and then to transfer and store the human milk in the unit. It usually takes 24--30 hours between the preparation of fortified human milk and the administration of the last bottle or syringe


to fresh human milk, but longer times were not tested [50](#apa14259-bib-0050){ref-type="ref"}. On the other hand, one study reported that immunoactive components were preserved and the bacterial count decreased in human milk stored for nine months at −20°C [55](#apa14259-bib-0055){ref-type="ref"}. Definitions of the upper limit should consider these data, together with the decrease in vitamin C and lactoferrin reported after two to three months. Then, an upper limit of three months for human milk storage at −18°C could be proposed. Nine months could be acceptable in well‐controlled storage conditions, until further studies confirm that it is safe in different settings with different routine practices.

Proposed limits should aim to maintain fresh mother\'s own milk properties in routine daily practice, when storage conditions are not as well controlled as in research studies.Preferably, the storage should not exceed 48 hours at 4°C and three months at −18°C. However, longer storage durations could be acceptable, but could have a greater impact on the anti‐infectious and nutritional properties of human milk.

Pasteurisation has been shown to significantly decrease the concentration of lactoferrin, immunoglobulins, lysozyme and human milk cells [27](#apa14259-bib-0027){ref-type="ref"}. It has also been reported to decrease its bactericidal activity by 25% [27](#apa14259-bib-0027){ref-type="ref"}. The recommended shelf life of frozen pasteurised human milk is six to eight months [4](#apa14259-bib-0004){ref-type="ref"}, [8](#apa14259-bib-0008){ref-type="ref"}, [56](#apa14259-bib-0056){ref-type="ref"}.

Is the bactericidal effect of fresh mother\'s own milk sufficient to offset any microbial contamination of breast milk with pathogenic organisms? It has been shown that infants who received fresh mother\'s own milk were exposed to pathogenic bacteria without systematically developing an infection [38](#apa14259-bib-0038){ref-type="ref"}. On


[65](#apa14259-bib-0065){ref-type="ref"}. Our working group considered that this risk particularly concerned preterm infants born before 28 weeks or with a birthweight below 1000 g.

The working group feels that it is necessary to check the bacteriology of fresh mother\'s own milk under certain conditions. However, in the absence of strong evidence, it can be acceptable to give the infant human milk pending the result of the culture. Considering the available evidence, the working group proposes a strategy that is based on the conditions of the human milk collection and on the characteristics of the infant (Fig. [1](#apa14259-fig-0001){ref-type="fig"}). The review found scant data to determine the limits of gestational age and birthweight below which bacteriological testing could be recommended more precisely. As a result, the limits that have been established byNews About the Festival

News from other sources

Secretariat of the Pacific Community (SPC), Pago Pago, American Samoa, Tuesday 22 July 2008 – Both men and women, young and old played their respective roles in the official welcome ceremony for delegates to the Tenth Festival of Pacific Arts in American Samoa yesterday morning.

While the men were busy preparing for the ava ceremony (kava ceremony), the women were getting ready to display their finely woven mats.

Boys and girls also pitched in, taking their place beside their elders to help in welcoming guests to their shores.

Despite a downpour during the ceremony, the beautiful array of colourful outfits worn by the hosts and different groups from participating countries brightened the ceremony and kept spirits high.

Men in traditional dress took part in the ava


Malnutrition-related diabetes mellitus in young adult diabetic patients attending a Nigerian diabetic clinic.
Although malnutrition-related diabetes mellitus (MRDM) is reported to affect about 40-50% of young adult diabetics in the Indian subcontinent and possibly other tropical and subtropical countries, anecdotal reports have suggested its relative uncommonness in Africa. The presentation of subjects (aged 15-30 years) attending a major Nigerian diabetic clinic in 1984 was therefore reviewed. The results (i) confirm previous observations on the rarity of diabetes in young adult Africans: only 45 of a total of 756 registered diabetics presented when aged 15-30 years; (ii) indicate that classical MRDM from established clinical criteria was uncommon, affecting only about 6% of the subjects, the majority of whom were either atypically or classically insulin-dependent (about 90%), although a small proportionof f/5 - (-98)/5?
1
Let q be 4/(-14) + 232/28. Let h(g) = -g**2 + 8*g + 1. Let l be h(6). Let k = l - q. What is the units digit of k?
5
Suppose -s + 1272 = -3*s. What is the units digit of (-2)/15 + s/(-45)?
4
Suppose 2*n = -3*n - b - 55, -20 = -4*b. Let g = n - -40. What is the tens digit of g?
2
Let l(a) = a**3 - 7*a**2 + 7*a - 1. Let x be l(6). Let c = -1 - -1. Let t = x - c. What is the units digit of t?
5
Let v(k) = -k**2 + 5*k - 2. Let c be v(3). Let g be (14/(-6))/(c/12). What is the units digit of (3 + g)*(-3 +


-i**3 - 3*i**2 - 4*i - 3. Let g(x) = x**3 - x**2 - 2. Let b be g(2). Suppose -b*f + 0 - 4 = 0. What is the units digit of y(f)?
1
Let s = 5 + -2. What is the units digit of 2 + (2 - s) + 1?
2
Suppose 70 = -5*n + 5*y + 275, -y = 3*n - 135. What is the units digit of n?
4
Let r(n) = -n + 4. Let y be -3 + 2 + 1 + 0. Let b be r(y). Suppose -4*f - 10 = 2*u, -u + b*f = 4*u - 31. What is the units digit of u?
3
Let f = 221 + -68. What is the units digit of f?
3
Let w be (-1)/(-3*(-2)/42). Let t =for long periods of time in a marginal neighborhood (where my main job is). Peter White--and Carradice, I believe--recommend looping the attachment straps so that they buckle inside the bag. That makes for a more stable and secure mount, as it allows the top of the bag to sit neaerly flush with the bag loops. But it doesn't make for easy dismounting.

So what did I do? Well, I unbolted the springs and bag loops from the rear plate on the Gyes. And I substituted keyring clamps for the loops:

Notice the tabs at the top of those clamps. I push them toward the saddle, which opens them. And when I let go, they close very securely:

I simply looped the regular mounting straps a couple of times through rectangular coupler


1. Field of the Invention
The present invention relates to an information processing method, an information processing apparatus, and an information processing program used for variable data printing (VDP).
2. Description of the Related Art
With the recent development of high-speed, high-quality electrophotographic or ink jet printing equipment, a new print-on-demand (POD) market is emerging in addition to the conventional print market. POD aims at treating a relatively small-lot print job than that for conventional printing equipment without using a large device or system in a short delivery period. Therefore, POD takes full advantage of a digital imaging device such as a digital copier and a digital multifunction device instead of a large-scale printing device and method to implement digital print using electronic data.
Such POD employs more advanced digital technology thanTitan isn’t necessarily considered a raid, it was one of the first pieces of content that Sudo had made for Final Fantasy XIV. When he joined the team, he was expecting to be given work on a primal that is good-looking, or rather, some primal he would like to be looking at, but alas… he got Titan. When creating Titan, hard mode he unintentionally made mechanics that made players fall constantly, making him wonder why people can’t stay alive. He never put lag into consideration, hence why it can be quite difficult to clear for players that have even a bit of lag. One of the examples is the short cast time for Titan’s ability Weight of the Land.

He said that this was an eye opener for him,


small. The text says:

Concept for Rafflesia:

A monstrous plant whose bodies and vines are clad in thorns.

Modeled after the rafflesia flower, with powerful poisons, pollen attacks, and nasty status effects.

The embodiment of the vile toxins and thorns seen in plants.

It should also use a special sap to lure in and manipulate bugs (bees, etc.).

Spouting poisons from its mouth and consuming various things.

Spread seeds around the field, creating thorn patches when they grow.

The look of a plant that’s undergone abnormal growth from dark matter.

Carnivorous. Though it normally appears docile and slow, it’s incredibly fast when targeting its prey.

These are only general ideas, but it should have these kinds of attacks:

Swinging vine attack: frontal area attack with vines

frontal area attack with vines Rampage: violently flails its vines about hitting everything aroundof protein lysate taken for immunoprecipitation served as input to confirm efficient transfection. (C) Comparison of LC3-I and LC3-II levels in HEK293T cells expressing (lanes 5--8) and not expressing (lanes 1--4) ApoL9-V5. *Apol9-V5* was transfected into cells by the calcium phosphate method. Cells transfected with empty vector (*pBApo-EF1α pur*) served as control. β-actin was used as a loading control.

Since the conversion of the cytosolic form of LC3 (LC3-I) to LC3-PE conjugate (LC3-II) occurs at the onset of autophagy ([@BIO045930C17]), we investigated if overexpression of ApoL9 had any influence on levels of lipidated LC3 (LC3-II). HEK293T cells were transfected with either control plasmid or plasmid expressing *Apol9-V5*, and to induce autophagy the cells were starved of amino acids by culturing in Earle\'s Balanced Salt Solution (EBSS) for different time


distribution pattern of ApoL9Δ111-123 and ApoL9Δ124-144 electroporated into B16F10 cells and treated with 10 mg ml^−1^ brefeldin A for 18 h, or 10 mM MG132 for 6 h. Note the difference in pattern after MG132 treatment. (E) Indirect immunofluorescence for ApoL9-V5 and LAMP1 in B16F10^L9Δ111-123^ and B16F10^L9Δ124-144^ after treatment with 200 nM bafilomycin A1 for 16 h. Dashed boxes are magnified on the right (inset) for clarity.

### Non-PE-binding mutants of ApoL9 differ in some of the properties exhibited by wild-type ApoL9 {#s2g2}

We subjected B16F10 cells expressing either ApoL9-V5-Δ111-123 or ApoL9-V5-Δ124-144 to various treatments to see which of the properties displayed by wild-type ApoL9 were abolished by deletions in the transmembrane region involved in binding PE. We had reported previously that lipofection of any plasmid into B16F10^L9^ cells caused rapid and dramatic aggregation of ApoL9 dueto its propensity to interact with dioleoylphosphatidylethanolamine (DOPE) in the transfection reagent ([@BIO045930C1]). So, firstly, lipofection of an empty (insertless) plasmid into cells stably expressing these mutants (B16F10^L9\ Δ111-123^ or B16F10^L9\ Δ124-144^) did not result in aggregation of ApoL9, confirming that these mutants were unable to interact with the DOPE in Lipofectamine 2000 ([Fig. 6](#BIO045930F6){ref-type="fig"}B). Secondly, the alterations of ApoL9 distribution in the cells when treated with bafilomycin A1 and brefeldin A, notably the mitochondrial localization of ApoL9 and curved, thread-like structures, were not seen in the mutants ([Fig. 6](#BIO045930F6){ref-type="fig"}C--E). Interestingly, localization to juxtanuclear lysosomes was still observed in bafilomycin A1-treated cells ([Fig. 6](#BIO045930F6){ref-type="fig"}E). Further, the clustered pattern of ApoL9 is not seen when treated with chloroquine-EBSS for shorter time periods, but localization to lysosomes persisted on long-term treatment with chloroquine


helical wheel at <http://www.bioinformatics.nl/cgi-bin/emboss/pepwheel>. Note the basic residues clustered on one side of the helix.

Since these structures resembled microtubules, we lipofected ApoL9-V5 into B16F10 cells and treated the cells with either nocodazole or paclitaxel (Taxol), a microtubule-depolymerizing agent and a microtubule-stabilizing agent respectively. All fibre-like structures disappeared in ApoL9-lipofected cells after a 3-h nocodazole treatment, while their abundance increased (including in the cell periphery) on paclitaxel treatment ([Fig. 7](#BIO045930F7){ref-type="fig"}C), indicating that ApoL9 localizes to microtubules. Further, treatment of the B16F10^L9^ cell line with paclitaxel led to ApoL9-V5 becoming visible on microtubules, which had become stabilized due to the effect of the drug ([Fig. 7](#BIO045930F7){ref-type="fig"}D). Another observation was that treatment of B16F10^L9^ cells with nocodazole greatly increased the number of ALIS-like structures in the cytoplasm ([Fig. 7](#BIO045930F7){ref-type="fig"}D; [Fig. S4E](Fig. S4E)), suggesting that the dynamicsnot identify an LIR that completely abolished interaction with GABARAP, it is worth noting that the key residues of the LIR motif candidate ~67~FPRL~70~ mutation, which when mutated reduced binding to GABARAP by 50%, are also conserved in rat ApoL9a. Though the contributions of some other phospholipids (like the various phosphoinosides) in autophagy - membrane remodelling and mTOR regulation - are well catalogued ([@BIO045930C6]), the role of PE in these processes is rather unclear. Shatz et al. state that, in addition to being conjugated with LC3, PE might directly affect lipid bilayer properties of the autophagosome and isolation membrane because it is a cone-shaped lipid and could influence curvature at the leading edge of the forming autophagosome ([@BIO045930C37]). Nath et al. reported a direct correlation between the efficiency


worth noting is that ApoL9 has been reported to interact with PHB1 and PHB2 ([@BIO045930C22]), two proteins of the inner mitochondrial membrane (IMM) that have been implicated in controlling IMM organization by acting as protein and lipid scaffolds ([@BIO045930C34]). Further, PHB2 has been identified to function as a receptor for mitophagy on the IMM by bridging LC3 and depolarized mitochondria whose outer membranes have ruptured ([@BIO045930C44]). How ApoL9 could fit in this complex scheme of events is a topic for future study.

It has been reported ([@BIO045930C25]) that intact mitochondria could be expelled from cells undergoing TNF-α-induced necroptosis and that this appeared to happen before the disruption of the plasma membrane, suggesting an active mechanism of release. Several other reports have also suggested that molecules derived from mitochondria andunder certain conditions, because in normal conditions it does not seem to accumulate in these organelles. This points to a possibility of ApoL9 being involved in the later stages of autophagy, when autophagosomes mature and autolysosomes come into play. The thread-like structures do not accumulate in cells expressing the non-PE-binding mutants; it is likely that these structures are formed as a result of the prolonged downstream block in the autophagic process due to the action of bafilomycin A1. It is widely accepted now that the terminal step of autophagy is a process called autophagic lysosome reformation, in which a clathrin-based budding mechanism facilitates the growth and elongation of tubules from autolysosomes along microtubules, followed by scission of proto-lysosomes ([@BIO045930C35]; [@BIO045930C7]). However, it is still very unclear how different


platform (GE Healthcare). Quantitation of western blots was done using the software ImageJ, and graphs were plotted using GraphPad Prism, version 6 (GraphPad Software, California, USA). Blots were stripped using a buffer comprising 62.5 mM Tris-HCl pH 6.8, 2% SDS and 100 mM 2-mercaptoethanol, and re-probed for loading controls and other proteins.

Protein pull-down and co-immunoprecipitation {#s4i}
--------------------------------------------

For GST/MBP pull-down assays, recombinant GST-fusion/MBP-fusion constructs were transformed into BL21-DE3 *E. coli*, and glycerol stocks of colonies were made at a final concentration of 15% glycerol. The cultures were inoculated into LB medium and induced with 0.5 mM IPTG for 3.5 h at 37°C. After centrifugation, the pellets were lysed with a lysis buffer (20 mM Tris-HCl, 200 mM NaCl, 1 mM EDTA, pH 7.4, with added 1 mM PMSF). The solution was sonicated to lyse the cells and clarifiedMarvell, Indilinx, JMicron and even SanDisk are now vying for control of the market.

With healthy competition, significant performance improvements and (hopefully) improved reliability in the consumer SSD space, Intel will actually begin defocusing itself from this market over the coming years. Intel needs to keep margins as high as possible to appease shareholders, and the consumer SSD business is in a race to the bottom. Dollars per GB are all that matter here once you deliver a certain level of performance and reliability.

Intel won't abandon the consumer SSD market completely, it will still compete in the high end space but there's a good reason that the mainstream moniker has been dropped from Intel's product names. Intel will shift more of its attention to the enterprise space, bringing that


News and Culture Intertwined

Elon Musk: Too Strung-Out to Be Flying Rockets?

Reports from the Centers for Disease Control and Prevention in Atlanta indicate that Elon Musk is “way too strung-out to by flying rockets around town.”Said lead anthropologist Mark Weinwright, “We’ve been monitoring his vitals for the past eighteen hours at this point and, well, it’s just pretty clear that he’s not fit to be flying rockets around.”

Musk had reportedly purchased over $40,000 worth of StompRockets from Amazon over the last two weeks to help inspire his newest design for SpaceX.Amazon customer service representative Melissa T. said in a press conference on Thursday that “He kept calling to get them in gift wrap.I tried to explain that you just need to select that option during checkout but he didn’t delivery of mail.

CCoonnnneeccttiioonn ccaacchhee lliimmiittaattiioonnss

Postfix SMTP connection caching conflicts with certain applications:

  * With Postfix versions < 3.4, the Postfix shared connection cache cannot be
    used with TLS, because an open TLS connection can be reused only in the
    process that creates it. For this reason, the Postfix smtp(8) client
    historically always closed the connection after completing an attempt to
    deliver mail over TLS.

  * Postfix connection caching currently does not support multiple SASL
    accounts per mail server. Specifically, Postfix connection caching assumes
    that a SASL credential is valid for all hostnames or domain names that
    deliver via the same mail server IP address


OBJECTIVE: Ministries > Laughing Jesus > LOL Sticker (White)

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Express yourself and make it stick! Our personalized stickers are perfect for showcasing your humor, political views, causes, beliefs, or just your awesome personality. Express yourself and make it stick! Our personalized stickers are perfect for showcasing your humor, political views, causes, beliefs, or just your awesome personality. Browse more products: Drag the square at the left to choose the part of your image you want to use. Tips: Click and drag any corner to resize; click and drag from thewould be immediately either positive or neutral (based on the polling published). How they might react in light of your now suggesting short term negatives, and if you manage to convince them that is likely, I dont know.

To JiB’s ““No one is arguing that Brexit will be an instant success.” we can now add DD’s ““Nobody has ever pretended this would be simple or easy” in the Commons today.

As Keir Starmer pointed out, that’s exactly what a lot of Brexiters have been pretending, citing Liam Fox’s assurance that a deal with the EU would be, “one of the easiest deals in human history” to negotiate.

It’s all getting a bit difficult, isn’t it? Perhaps when the history is written, now will be seen as the moment the wheels started


effectively subsidises from general UK tax payers to low waged employees. Indirectly these are also subsidies to employers who pay rock bottom wages. A move away from the George Osborne “gig economy” / JAM model.

The revenue HM Government saves from reducing the leaching of revenue in this fashion can be used instead to pay nurses, teachers ans kwy public sector employees better. It can also be used to train UK nationals in akill shortagea and even reverse the scandal of tuition fees.

Thanks for the information, Howard. Do you have a view on Mrs may’s proposals for more “rolling” talks – their purpose and the potential outcomes? By that I mean what might happen – particularly to Mrs May’s position and the Brexit talks. i assume the EU willthey don’t themselves realise of accept that they have moved.

And then we have @Pete B’s intervention, summoning the spirit of Agincourt and Dunkirk. Barking, irrelevant and highly emotional, but not unexpected. I’m still trying to work out what relevance events at Dunkirk seventy years ago have now. It was the culmination of probably the worst land campaign the British army ever engaged in, with a disastrous humiliation exposing the uselessness of our military planning, political leadership, equipment, tactics and fighting abilities. Abject failure in Europe. Perhaps that’s the lesson?

It was so bad that we needed massive US bailouts, men, machines and money, and Dunkirk should really be argued as the point when the UK lost it’s Empire and it’s claim to be world leader. Shameful that some should


can answer this question better.  Once wine finished installing (from Software Center)

I copied an EXE file over (utorrent.exe)

The I right clicked the file, and choose Open With --> Wine Windows Program Loader, and it opened.  See image below.

Health Highlights: Feb. 8, 2018

Here are some of the latest health and medical news developments, compiled by the editors of HealthDay:

San Francisco to Open First 'Safe Injection Sites' in U.S.

San Francisco plans to open two legal safe injection sites in July, and they could be the first such facilities in United States.

A task force's recommendation to open the sites was unanimously endorsed by the San Francisco Department of Public Health, CNN reported.

At the sites, people can use drugs they bring with them and are supervised by staff who know how respond to overdoses or other medical emergencies. Staff also offer counseling and referrals to various health and social services.

Such sites are needed in light of the steep rise in opioid overdose deaths in the U.S., according to San


After picking up a hard fought point at Nissan Stadium, Nashville SC heads out on the road against Bethlehem Steel FC.

Bethlehem sits fifth in the Eastern Conference table, after defeating the Richmond Kickers 4-1 and losing to the Tampa Bay Rowdies 2-0. Saturday’s match represents a true test for Nashville after opening against the defending USL champs Louisville City FC and playing a defensive first Pittsburgh Riverhounds.

The Boys in Gold are in search of their first goal and first win of the season. The game kicks off at 1 p.m. CT at Goodman Stadium. Nashville fans can watch the game streamed on nashvillesc.com.

Nashville Needs a Goal

After being shut out against Louisville City and Pittsburgh, Nashville head coach Gary Smith said his team has been working hard on theof the diversity of this family in China. Materials for this study were collected in the field from 2002 to 2012, with 22 species represented by a single individual and 111 species represented by two to nine individuals (an average of three samples per species). The Lauraceae expert at KUN, Hsi-Wen Li, who is one of the co-authors, identified the vouchers ([S1 Table](#pone.0175788.s001){ref-type="supplementary-material"}) based on the reproductive or vegetative characters available. All vouchers were stored at the Herbarium of Xishuangbanna Tropical Botanical Garden (HITBC).

DNA isolation, amplification and sequencing {#sec005}
-------------------------------------------

Total genomic DNA was extracted from silica gel-dried leaf tissue or herbarium specimens using a modified CTAB method \[[@pone.0175788.ref049]\]. The plastid markers *rbc*L, *mat*K, *trn*H--*psb*A and nuclear markers ITS and ITS2 were amplified using multiple primers, following the suggestions of


+I+G substitution models respectively. As the consensus trees obtained from the BI and MP analyses were almost identical in their topologies, only the Bayesian consensus tree based on *rbc*L+*mat*K+*trn*H--*psb*A+ITS with PP (Posterior Probabilities) and BS values (Bootstrap Support values) is presented here ([Fig 5](#pone.0175788.g005){ref-type="fig"}). The Bayesian tree contains three principal Lauraceae clades, with *Hypodaphnis* strongly supported in BI and MP analyses as their sister group. Clade 1 (PP = 1.00, BS = 100%) includes members of the *Cryptocarya* group; *Caryodaphnopsis* and *Neocinnamomum* form Clade 2 (PP = 1.00, BS = 85%); the remainder, representing the *Persea* group, Laureae and *Cinnamomum* formed Clade 3 (PP = 1.00, BS = 98%). In the Clade 3, there is some support for a clade including the representatives of the *Persea* group (PPCampaigners unable yet to make Chevron

pay for the damages it creates.

Chevron, the eighth largest oil company in the world, has contributed $2.5 million to the Congressional Leadership Fund, a Super PAC seeking the election of Republicans to the House of Representatives. That, says campaignmoney.org, is the single largest contribution to a so-called Super PAC since the Supreme Court's Citizen United decision in 2010 allowed these organizations to advocate for candidates with money raised from corporations, unions and individuals in unlimited amounts.

Paul Blumenthal reports that the Chevron contribution is part of a shift on the part of oil and gas companies that gave 62 percent of their political contributions to Republicans in 1990 and 90 percent so far this election cycle. Total 2012 contributions from the industry reported, according


human oocytes has not been established and the number of oocytes utilised up to now is still too low to determine a definitive methodology to be applied.
Human oocytes survival rate in cryopreservation depends, as well as on oocytes size, also on cryoprotectant used (composition, concentration and exposure time) and on freezing/thawing rate.
In the cryopreservation process, oocytes size is a very important parameter affecting the survival rate because the large quantity of water in ooplasm causes intracellular ice formation during the freezing, process: intracellular ice is one of the main responsible factors for intracellular structure damages.
Oocytes cryopreservation protocols usually include the following steps:    a) initially exposing the oocytes to a solution including a permeating cryoprotectant (e.g. 1,2-propanediol (PROH)), which aim is to reduce to a minimumQ:

Impossible to update some modules via Composer

I've updated a D8 website from 8.7 to 8.8.1 with SSH and composer.
For some modules (in SSH 3rd column is marked in yellow) it is not possible to update them. I understand that when they are marked in yellow some dependencies are missing?
The rest of the modules are updated successfully.
Below the list of modules that needs an update (3rd column is marked in yellow):
drupal/blazy         1.0.0-rc5 2.0.0-rc6 Provides basic bLazy integration for lazy loading and multi-serving images.
drupal/file_mdm      1.1.0     2.0.0     Provides a service to manage file metadata.
drupal/file_mdm_exif 1.1.0     2.0.0     Provides a file metadata plugin for


EXIF image information.
drupal/file_mdm_font 1.1.0     2.0.0     Provides a file metadata plugin for TTF/OTF/WOFF font information.
drupal/slick         1.2.0     2.0.0     Slick carousel, the last carousel you'll ever need.
drupal/slick_views   1.0.0     2.1.0     Provides Slick carousel integration with Views.

In composer.json: slick and slick_views are added. Other above modules are not located in the composer.json:
{
    "name": "drupal-composer/drupal-project",
    "description": "Project template for Drupal 8 projects with composer",
    "type": "project",
    "license": "GPL-2.0-or-later",
    "authors": [
        {
              "composer-exit-on-patch-failure": true,
        "patchLevel": {
            "drupal/core": "-p2"
        },
        "installer-paths": {
            "web/core": ["type:drupal-core"],
            "web/libraries/{$name}": ["type:drupal-library"],
            "web/modules/contrib/{$name}": ["type:drupal-module"],
            "web/profiles/contrib/{$name}": ["type:drupal-profile"],
            "web/themes/contrib/{$name}": ["type:drupal-theme"],
            "drush/Commands/{$name}": ["type:drupal-drush"]


journal Angewandte Chemie (it’s German).

Living things make molecules through a series of chemical reactions, similar to how car makers produce cars on assembly lines. Enzymes act as the workers/robots, speeding up the reactions by helping put the pieces together. Actually making psilocybin requires mapping the biological factory.

A 1968 paper (obviously it was in 1968) offered a proposed order of events leading to a finished psilocybin molecule, by adding radioactive elements and watching what happened to them on the assembly line. The researchers thought that maybe tryptophan, the amino acid everyone wrongly says makes you sleepy, was the first piece, which then went through four successive steps to become the finished product.

The new study shows that the 1968 paper got the order wrong, and introduces the responsible genes andsyntactic forms for expressing compound types. First, pairs, triples, and larger structures can be written using tuple-syntax, comma-separated types inside parentheses. Thus, (Int,Bool) is a structure with both an Int and a Bool component. Second, lists have a syntactic shortcut, using square brackets. Thus, [Int] is a list of Int .

Haskell also has other container types. A container that may contain one Int has the type Maybe Int , which is read Maybe of Int. These container names also start with uppercase letters.

Types can be nested to any depth. For example, you can have a [(Maybe (Int,Bool))] , read as list of Maybe of (Int and Bool).

Polymorphic values are expressed using lowercase letters and play a similar role to void* pointers in C and polymorphic arguments in the


a good starting point for further reading.

Embedded DSLs

An EDSL is a library in a host language that has the look, feel, and semantics of its own language, customized to a specific problem domain. By reusing the facilities and tools of the host language, an EDSL considerably lowers the cost of both developing and maintaining a DSL. Benefiting from Haskell's concise syntax, the Haskell community—and the functional programming community in general—has taken the ideas of EDSLs and developed a large number of DSLs that provide higher-level interfaces and abstractions for well-understood systems. What follows are two examples of EDSLs: one for automatically generating test cases for software testing; and a second for specifying hardware-circuit behaviors.

Example EDSL: QuickCheck Properties

Consider the challenge of writing test cases—or more specifically, writing the propertiesTrue : False : False : ...

GHCi> counter low (toSeq (cycle [True,False,False]))

1 : 1 : 1 : 2 : 2 : 2 : 3 : 3 : 3 : ...

As well as basic signal types, you can build circuits that operate on Haskell functions directly, provided the domain of the function is finite. The Rep capability is used to signify that you can enumerate all possible representable values in a type, giving the funMap function:

funMap :: (Rep a, Rep b) => (a -> Maybe b) -> Signal a -> Signal b

The generated circuit is implemented using a ROM, and you can generate control logic directly in terms of Haskell functions and data structures. As an example, consider a small ROM that stores the square of a value:

squareROM ::


embedding combined with a specific run function gives the same result. For a deep embedded DSL, the run function restores the capability of the shallow embedding, but another function takes the embedded structure and uses it in some creative way.

To make deep DSLs practical, there are two additional tricks in the DSL folklore that are almost always used. The first trick allows the capture of functions, via dummy arguments. The second trick can observe loops, via some form of observable sharing.

How to Extract a Deep Embedding from a Function

Expressing function calls in terms of constructors and building expression trees is useful, but by itself is a gimmick. With careful construction, however, you can also capture function definitions, as well as other syntactical structures, directly from a deep embedding.Axelsson, E., Claessen, K., Sheeran, M., Svenningsson, J., Engdal, D., Persson, A. 2011. The design and implementation of Feldspar: an embedded language for digital signal processing. In Proceedings of the 22nd International Conference on Implementation and Application of Functional Languages. Springer-Verlag: 121-136.

2. Bellows, P., Hutchings, B. 1998. JHDL—an HDL for reconfigurable systems. Annual IEEE Symposium on Field-programmable Custom Computing Machines.

3. Bracker, J., Gill, A. 2014. Sunroof: a monadic DSL for generating JavaScript. Practical Aspects of Declarative Languages. Matthew Flatt and Hai-Feng Guo, eds. Volume 8324, Lecture Notes in Computer Science: 65-80. Springer International Publishing.

4. Claessen, K., Hughes, J. 2000. Quickcheck: A lightweight tool for random testing of Haskell programs. In Proceedings of the 5th ACM SIGPLAN International Conference on Functional Programming: 268-279.

5. Claessen, K., Sands, D. 1999. Observable


Higher-Order and Symbolic Computation: 1-20.

12. Hutton, G. 1993. The Ruby interpreter. Research Report 72, Chalmers University of Technology.

13. Jones, G., Sheeran, M. 1990. Circuit design in Ruby. Formal Methods for VLSI Design. Jorgen Staunstrup, ed. Elsevier Science Publications.

14. Mainland, G., Morrisett, G. 2010. Nikola: embedding compiled GPU functions in Haskell. In Proceedings of the 3rd ACM SIGPLAN Symposium on Haskell: 67-78.

15. Matthews, J., Cook, B., Launchbury, J. 1998. Microprocessor specification in Hawk. In Proceedings of the International Conference on Computer Languages: 90-101.

16. Persson, A., Axelsson, E., Svenningsson, J. 2012. Generic monadic constructs for embedded languages. In Implementation and Application of Functional Languages: 85-99. Springer.

17. Peyton Jones, S. L., ed. 2003. Haskell 98 Language and Libraries—The Revised Report. Cambridge, England: Cambridge University Press.

18. Peyton Jones, S. L., Wadler, P.even faster polymorphism.

Ulan Degenbaev, Michael Lippautz, Hannes Payer - Garbage Collection as a Joint Venture

Cross-component tracing is a way to solve the problem of reference cycles across component boundaries. This problem appears as soon as components can form arbitrary object graphs with nontrivial ownership across API boundaries. An incremental version of CCT is implemented in V8 and Blink, enabling effective and efficient reclamation of memory in a safe manner.

David Chisnall - C Is Not a Low-level Language

In the wake of the recent Meltdown and Spectre vulnerabilities, it’s worth spending some time looking at root causes. Both of these vulnerabilities involved processors speculatively executing instructions past some kind of access check and allowing the attacker to observe the results via a side channel. The features that led to these


Q:

A tricky problem about matrices with no $\{-1,0,1\}$ vector in their kernel

A Hankel matrix is a square matrix in which each ascending skew-diagonal from left to right is constant. Let us call a matrix partial Hankel if it is the first $m<n$ rows of some $n$ by $n$ Hankel matrix. I was posed this question by a mathematician a few years ago and I have been completely stuck on it ever since.   Let us assume all our partial Hankel matrices have elements which are chosen from $\{-1,1\}$.

Does there exist an $m$ by $n$ partial Hankel matrix $M$ such that it has $m < n/2$ rows and there is no non-zero vector $v\in\{-1,0,1\}^n$ in its kernel?

Such matrices certainly do exist for non-Hankel $m$ by $n$ $\{-1,1\}$-matrices.
Other that(i.e. at least one $M$ which does not admit any nontrivial solution of $Mw=0$). This holds independently of whether we require in addition that $M$ has a Toeplitz, Hankel or circulant form. Moreover, not just one but probably the majority of all matrices of the specified form will have the wanted property.

Note that the condition $(5)$ is asymptotically weaker than $m>n/c$ for any real constant $c>1$, which implies that for any such $c$ and sufficiently large $n$ there should exist $n$ by $m$ Toeplitz (Hankel, ...) matrices with $m<n/c$ which have the wanted property. In the Question, $c=2$ was chosen.
A final note: Of course, in the present form the entire argument is not mathematically rigorous, since it relies on several uncontrolled approximations. I believe, however,


She was extremely organized and kept me on track. Getting married is very stressful and hectic; it was wonderful and relaxing to fall asleep to the sounds of a trickling fountain flowing in the garden. Also, the breakfasts she served were so delicious that I would consider staying at Sand Rock again just for the food! A big, big thank you to Kris and all of her staff! Read less

Services Used: Wedding Venue

Thanks for visiting the vendor listing for Sand Rock Farm

Please let this vendor know that you found them on the WeddingWire Network.By Laurens Lavrysen

In the case of Dubská and Krejzová v. Czech Republic, the Strasbourg Court had to pronounce itself on the regulation of home birth under Czech law. While on the one hand Czech law allowed for home births, on the other hand it prohibited midwives from assisting them. In its judgment of 11 December, the Court found no violation of the right to respect for private life (Article 8), mainly based on the increased risks to the lives and health of newborn and mother vis-à-vis a hospital birth in case of complications. The Court thereby endorsed the paradoxical Czech legal framework under which relatively safe home births with the assistance of a midwife are prohibited on health grounds, whereas unsafe home births without such assistance are allowed.


hand. The majority chose to construct the case as one involving a narrow conception of ‘interference’, i.e. a question of negative obligations. The Court restricted its examination of the interference to the mere fact of the state prohibiting midwives assisting home births, instead of focusing on the broader picture of how the legal framework at place in the Czech Republic limited women in genuinely exercising their choice as to the circumstances of giving birth. Respecting the ‘right of choosing the circumstances of becoming a parent’ requires more than absence of such direct state interference: instead of focusing at what the state should not do (the ‘negative’ aspect of this right), a more ‘positive’ interpretation of this right also requires us to look at what the state should inthis state decision, whereas in practice the possibility to choose for a risky homebirth without assistance is qualitatively different than the possibility to choose for a relatively safe home birth with the assistance of a midwife. Indeed, one cannot pretend that ‘nothing is lost’ in the field of choice by way of this active decision by the state.

Rather than constructing the case as either entirely concerning state action or entirely concerning state inaction, a more holistic interpretation of Article 8 placing women’s genuine choice at the centre of the inquiry would require to look at both ‘negative’ and ‘positive’ aspects of the case. In this respect, a line of legal reasoning from the area of the right to property (Article 1 Protocol 1) could be illuminating. In many


               if (!isExistSplash()) {
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                }
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                    var oldInfo = JsonConvert.DeserializeObject<Splash>(PlayerPrefs.GetString(SplashInfoKey));
                    if (oldInfo.id == splash.id && oldInfo.image == splash.image) {
      The goal of hybrid development is to combine, in a single hybrid, various desirable traits. For field crops, these traits may include resistance to diseases and insects, resistance to heat and drought, reducing the time to crop maturity, greater yield, and better agronomic quality. With mechanical harvesting of many crops, uniformity of plant characteristics such as germination, stand establishment, growth rate, maturity, and plant and ear height is important. Traditional plant breeding is an important tool in developing new and improved commercial crops.


accommodate the very early ones we found? Heck no!
Even more recent composers run into this problem. Bruckner wrote and published nine symphonies. But then, after his death, they found an early trial-run symphony that he wrote but never published, so they decided to call it Symphony No. 0 ("Die Nullte"). Then they found another one, so they called it (not Symphony No. -1, that would have been awesome), but Symphony No. 00.
And so it goes...

and A. B. 100, LEGISLATIVE COUNCIL NOTE, at 14 (1953) (enacted), in support of this proposition.
*739 In Dickenson, 75 Wis. 2d at 50-51, 248 N.W.2d at 449, our supreme court held that the victim's belief that Dickenson showed her a gun, in absence of positive testimony that Dickenson was in fact armed with a dangerous weapon, was insufficient to support a conviction of armed robbery. Similarly, the court held in McKissick, 78 Wis. 2d at 179, 254 N.W.2d at 219, that a defendant pretending to be armed is insufficient to support a conviction of armed robbery because being armed in fact is a necessary element of the crime. Frey argues that if hands were properly considered dangerous weapons, the court would necessarily have reached the opposite conclusion in


both cases. However, these cases construe a different statute than the one before us. Also, neither case involved the defendant using his hands in a manner likely to cause death or great bodily harm. Additionally, both of these cases were later superseded by the new armed robbery statute as amended in 1979. See sec. 943.32(2), Stats. Therefore, we conclude these cases are unhelpful.
The judiciary committee's note is equally unhelpful under these circumstances. The note distinguishes between things that are considered dangerous weapons per se (e.g., brass knuckles) and things that are not inherently dangerous but can be used or intended to be used in a dangerous manner (e.g., razors and baseball bats). The note does not discuss whether animate objects or parts of the accused's anatomy may be(Change the view of fragment)

I change only the view of ContactsFragment by doing a bad kind of hack.
I change the onCreateView() shown above to this -
    @Override
    public View onCreateView(final LayoutInflater inflater, final ViewGroup container, final Bundle savedInstanceState) {
        //Set the view to R.layout.contacts_primary
        rootView = inflater.inflate(R.layout.contacts_primary, container, false);

        //Set the view to R.layout.contacts_secondary
        if(getActivity().getIntent()!=null && getActivity().getIntent().getBooleanExtra("s", false)) {
            rootView = inflater.inflate(R.layout.contacts_secondary, container, false);
            Log.e(tag,getActivity().getIntent().getExtras().toString());


 startActivity(new Intent(getActivity(), ContactsActivity.class).putExtra("s",true));
            }
        });

Now everything works as I want and flawlessly.
But I have a very strong feeling that either all of it is wrong and Fragments aren't supposed to work this way or I am using a hectic hack to achieve what can be done by few lines of code.
So please let me know what is it? And if there is a standard way of doing what I am trying to do.

A:

For me passing additional argument on which base fragment decides wich layout to use seems totally ok. But there is cleaner way of doing what you want to achieve without starting another activity.
First of all passStructure of long-term average frequencies for Kuramoto oscillator systems.
We study the long-term average frequency as a function of the natural frequency for Kuramoto oscillators with periodic coefficients. Unlike the case for more general periodically forced oscillators, this function is never a "devil's staircase"; it may have plateaus at integer multiples of the forcing frequency, but we prove it is strictly increasing between these plateaus. The proof uses the fact that the flow maps for Kuramoto oscillators extend to Möbius transformations on the complex plane, and that Möbius transformations have particularly simple dynamics that rule out p:q mode locking except in the case of fixed points (q=1). We also give a criterion for the degeneration of an integer plateau to a single point and use it to explain the


[Iatrogenic demineralizing osteopathies].
Long-term corticosteroid therapy is the most frequent and most severe cause of iatrogenic osteoporosis. Hypocalcaemia, subsequent to the induced negative calcium balance, may lead to secondary hyperparathyroidism. Corticosteroids also affect bone itself, probably by disrupting the production of growth factors. Bone resorption increases and bone formation decreases leading to a reduction in total bone mass. The relative immobilization resulting from the corticoid-induced myopathy or the underlying disease may accelerate the process. On the average, after one year of treatment, 5% of the bone mass is lost, and loss may reach as much as 10 to 30% at certain sites. Nearly 40% of all subjects on long-term corticosteroids suffer fractures. Other iatrogenic causes include anticonvulants which perturb phosphocalcium metabolism, 1-thyroxin which leads to bone loss when administeredclass Facebooker::Service::TyphoeusMultiService <  Facebooker::Service::TyphoeusService

  def initialize
    @result_objects = []
  end

  def parse_results?
    false
  end

  #define a method that returns nothing
  define_remote_method :async_post,  :on_success => lambda {|r| puts "."}

  def perform_post(url,params)
    add_result(self.class.async_post(:base_uri=>url,:params=>params))
  end

  def add_result(obj)
    @result_objects << obj
  end

  def process
    # we need to access all objects to make sure the proxy has made the request
    @result_objects.each(&:nil?)
    @result_objects = []
  end
end


Jürgen Klopp has set Liverpool a target of reproducing the sort of form that saw them demolish Manchester City 4-1 at the Etihad Stadium on home soil.

The Reds were simply irresistible as they swept aside Manuel Pellegrini’s men with a high-intensity performance on Saturday evening.

It followed on from a similarly impressive showing away to Chelsea last month in which they recorded an emphatic 3-1 success over the reigning champions.

Now Klopp is keen for his players to conjure up similar kind of displays at Anfield.

“I would love to win a game like this at Anfield,” said the boss. “That’s our next challenge. We now play Bordeaux and then Swansea, and at this moment I don’t know enough about Swansea.

“If they saw our game against Crystal Palace maybe they willmore administrators, who, coincidentally make more than the teachers do (and, indeed, is seen by many teachers as career advancement over dealing with disruptive students).

So, no, I don't blame the teachers. Many, if not most, are highly motivated. They have to be. I blame the system they work in.

I agree that the public schools are being asked to solve too many non-education related problems, but there is no obvious way to go back.

In the 1960s, when my wife attended public high school in New Haven, all the Yale professors sent their kids to New Haven public high schools, many of those kids were her friends. There were some very rigorous academic programs offered to top performing students (such as my wife).

But at some point priorities changed, those courses


personally invested in the topic. But I still think it's a great idea that should be available to more kids who are stuck in stultifying high schools--which is, apparently, most of them.

Head: Skipping kids ahead is an old-style solution. My mother went to college when she was 16, back around 1940. The solution we should demand is better high schools. In my city, Madison, we have very challenging high schools, and you definitely would not see survey results like this.

The problem with starting college so young is that unless everyone does, many that young are not socially ready, esp. guys.

I knew some kids who started a couple of years early. At 18, 19, we were starting to shack up soon after starting college. These kids, at 15, 16,and AP classes were so lame that someone could miss 112 classes and still have straight A's, the problem was theirs not mine.

And I went to what was considered to be a very good school district. (We had many people go to top colleges.)

The government education monopoly is a disaster. I'll be saving money to send my kids to private school.

and I hope Freeman that you as a parent will ensure your children at whatever school they attend learn that attending class is part of the requirment.

Where were your parents when you "earned" more than one hundred absences? and why did the school wait that long to haul your butt in?

Being brilliant doesn't excuse a lazy attitude. The ol'e inspiration vs. perspiration adage is precisely what brings changes--


work done quickly and put my energy into other things that are worthwhile. Read books that interest you, do some writing, get involved in activities in your community, or pursue some artistic endeavor. Try to find out what interests you and pursue that. College is not that far away. Concentrate on getting ready to go to a place that can get you into an area of work that will be valuable and rewarding. I'll bet if you talked to your favorite teacher, he or she would help you.

Um, just going to private school is no guarantee of a challenge. With a similar level of effort, I went from a 4.1 in a well respected private hs to a 1.6 my first term in college. I did eventually learnWe haven’t changed anything about the decks themselves, since apparently women want to play Magic just like everyone else.

We’ve also created an entire Magic for Her store on CardKingdom.com, featuring some brand-new, limited-edition Card Kingdom playmats. Grab all the supplies you need, and you, too, can be the girl playing Magic that prompts everyone to say, “Whoa, a girl playing Magic!”


Rico. Brock further states that MAI representatives visited the island on several occasions to assist in consummating sales of MAI products in coordination with Brock salesperson Infanzón. MAI typically followed up on a sale, according to Brock, by sending a communication to the Puerto Rico customer either directly or through Infanzón, and also managed the shipping of the products to the island. Thus, MAI's contacts with the forum were not based on the unilateral actions of a third party.
Second, MAI's ongoing relationship with Brock and its salesperson in Puerto Rico from 1996 to 1998, the numerous sales of MAI products to the island as evidenced by the sales invoices attached to Brock's Opposition, and MAI's intention to continue supplying its products to the Puerto Rico market through directmental health (MCS12); where lower scores represent lower health. Time 2 data were available for 31.6% of the T1 hospital IDVA sample (T1 *n* = 101; T2 *n* = 32).

*HADS Hospital Anxiety and Depression Scale* \[[@CR25]\] comprises 14 items assessed on a 4-point ordinal scale. Seven items are totalled to produce mean scores for the two component subscales measuring Anxiety and Depression. Scores of 0--7 suggest 'normal' levels of anxiety or depression, 8--10 borderline 'abnormal', 11--21 'abnormal'. Time 2 data were available for 32.9% of the T1 hospital IDVA sample (T1 *n* = 97; T2 *n* = 32).

*Primary Care Post-Traumatic Stress Disorder Screen* \[[@CR26]\] is a 5-item measure that begins with an item designed to assess whether the participant has had any exposure to traumatic events over the course of their life. If the answer is


/ \[95% CI\]2.11.65 \[1.7, 2.5\]2.01.5 \[1.4, 2.6\]^a^ UK normative data for females \[56\]. Women score higher on anxiety scales, no significant differences in depression between men and womenNote. No statistical differences were found between T1 and T2 for health outcomes; all measures = *p* \< NS

survivors, levels of anxiety (T1 *M* = 12.2, 95% CI 10.6 to 13.5) and depression (T1 *M* = 10.5, 95% CI 7.9 to 12.2) were twice the national average. At T1, over half (62.6%) screened positive for Post-Traumatic Stress Disorder (PTSD) (T1 *M* = 2.1, 95% CI 1.7 to 2.5). Between T1 and T2 (3 months after exiting support for DVA), no changes were observed in health outcomes among hospital survivors. While survivors reported a lower level of physical (T2 *M* = 48.7, 95% CI 45.9 to 54.0) and mental health concerns at T2 (T2 *M* = 39.6, 95% CI 34.9 to44.3), specifically around anxiety (T2 *M* = 11.4, 95% CI 10.6 to 12.6), depression (T2 *M* = 8.6, 95% CI 7.9 to 10.0) and PTSD symptomology (T2 *M* = 2.0, 95% CI 1.4 to 2.6), no significant differences were observed; potentially owing to the small sample size.

DVA outcomes {#Sec12}
------------

Outcomes relating to the change in DVA assessed at the closure of cases revealed some positive changes in safety for survivors accessing both IDVA services (Table [6](#Tab6){ref-type="table"}). Survivors accessing hospital IDVA services were more likely to experience cessation of abuse at the point of exiting the service than survivors identified by community IDVA services (62.4% hospital; 48.3% community). Hospital survivors reported a higher level of reduction in physical abuse (86.2% hospital; 71.2% community), sexual abuse (82.4% hospital; 73.3% community), harassment and stalking (75.6% hospital; 52.4% community) and jealous coercive and


potentially leading to lower reductions in non-physical forms of abuse at the point of exit. In line with previous research, intensive support from IDVAs (five or more contacts) over a longer period and access to a greater number of community resources / programmes increased the likelihood of safety \[[@CR17], [@CR18]\]. These results demonstrate the importance of hospital-IDVAs working as part of a co-ordinated multi-agency response.

No changes were observed in health outcomes for survivors who had accessed the hospital IDVA. These findings may reflect the small size of the sample or the short time period at which health outcomes were assessed after case closure. However, 3 months after accessing support, reported levels of health were still proportionately lower than UK averages. Survivors accessing hospital IDVA services experienced diminished oddsand approved the final manuscript.

The Oak Foundation funded the evaluation through SafeLives for the original policy research. Secondary analysis and manuscript writing were not funded. The funding body provided financial support for the conduct of the policy research, not being involved in the design of the study, data collection, analysis, interpretation of data or in writing the policy research or article.

The datasets generated and/or analysed during the current study are not publicly available because consent was not sought for this purpose. Data may be available from the corresponding author on request.

Ethics for Themis: A multi-site evaluation of hospital-based domestic abuse service were approved by the South West 4 (Central Bristol) Research Ethics Committee. All participants gave written consent to take part. The conduct of the evaluation was overseen


Communication: State-to-state inelastic scattering of interstellar O2 with H2.
Molecular oxygen (O2) is predicted to be a major reservoir of elemental oxygen in dense interstellar molecular clouds. However, the abundance of O2 derived from astronomical observations is much lower than expected. Solving the discrepancies between models and observations requires a review of the chemistry and collisional excitation of O2 in space. In particular, O2-H2 collisions are crucial to derive O2 abundance in space from the interstellar spectra. A crossed molecular beam experiment to probe the rotational excitation of O2 due to H2 collisions at energies of 650 cm-1 is reported. Velocity map imaging was combined with state-selective detection of O2( X 3 Σ g - ) by (2 + 1) resonance-enhanced multiphoton ionization. The obtained raw O 2 +brought, in the federal court for western Texas, this suit against the receiver, praying, in the alternative, that the bonds be delivered to it; or that they be sold for its benefit; or that the claim be paid in full with interest. The receiver filed a cross-bill praying that the bank's title to the bonds be quieted.
The case was first heard upon motions to dismiss the bill and the cross-bill. The decision on the motions was postponed until after hearing the case upon the evidence. Thereupon the court dismissed the bill and entered *252 a decree for the receiver upon the cross-bill, holding that the pledge was void and that the Liberty Bonds constituted assets to be administered for the benefit of the general creditors of the bank.


expressed willingness to assent to the substitution, but only on condition that thereby it would be as fully protected as by the surety bonds. The bank and its attorney gave this assurance; and thereupon the pledge was substituted *253 for the surety bonds and these were cancelled. Without that assurance, the Railway would not have consented to the cancellation of the surety bonds; or if they had been cancelled without its consent, would have immediately withdrawn all of its deposits. In reliance upon the assurances and the pledge, the Railway continued until the failure to make deposits; and in fact increased its deposits.
National bank examiners commenced on August 6, 1931, an examination of the bank. Within a few days, they learned from the bank's books that the pledgev. Kennedy, *254 167 U.S. 362, 366; First National Bank v. Missouri, 263 U.S. 640. Confessedly the power to pledge assets to secure a private deposit was not granted in specific terms. The contention is that this power is incidental to the general grant of powers "necessary to carry on the business of banking . . . by receiving deposits"; and, hence, is implied.[3]
There is no basis for the claim that the power to pledge assets is necessary to deposit banking. The record is barren of evidence that the practice of so pledging assets has ever prevailed among national banks. And facts of which we take judicial notice indicate that among national banks such action must have been deemed contrary to good banking practice.[4] From the establishment of


Q:

SwiftCSV error finding .csv file

Project File Screenshot
I am experimenting with SwiftCSV to get data from a file, and so far I am having no luck. It seems like a very simple error that I cannot seem to fix - I am guessing it cannot find the file somehow. I have a "trainers.csv" file in the project (shown in screenshot) but every time I run this the code goes straight to the catch print statement - so there is something wrong in my try line.
func testCSV(){
    print("I got here")
    do {
        let csv = try CSV(name: "trainers.csv")
        print("Success?")

        //print(csv.rows)
   in the avd manager and I try to delete it, and error message pops up that says I can't because the emulator is currently running. Even when I reboot the computer, open the avd manager and try to delete I still get the same error.
I have tried

adb devices
  to find the device that is running but no devices get listed.

I get this error whether I am running the avd manager form Eclipse or from the command line. Does anyone know Why I am getting the NAND: Could not write file...file exists error or why I always get the message about the emulator running.
Regards,
John

A:

Try to check the free space on your hard drive....... its usually due to low storage space

A:

Try running df -h repeatedly while


el-Sisi because they believe his economic policy isn't strong enough.

"Sisi has lost the Copts' support, especially that of the youth, due to the disappointing economic performance and deteriorating security situation over the past four years," Mina Thabet, a social science researcher at the University of Aberdeen, told Al-Monitor.

"Economic difficulties prevailed over the past four years. Prices have increased twofold, the government has lifted subsidies on many goods, floated the Egyptian pound and imposed taxes on repetitive occasions. In addition, the economic ventures are ineffective," a Coptic university student said.

Meanwhile some youth don't believe el-Sisi's efforts to protect the Coptic community have been successful.

Regardless, el-Sisi is expected to win over much of the vote after several of his competitors have dropped out of the race.(Stafford), parcel of the duchy of Lancaster, Seney Park, and the rectory and parish church of Rolleston.

[Beds]: views of account of the property of Harrold, Caldwell and Markyate priories. 31-32 Hen. VIII.

Copy of lease by the prior and convent of Caldwell to Anthony Darcey of the rectory of Tolshunte manor, Essex. 20 Hen VIII

I found only one reference to Caldwell, Yorkshire.

Sir Richard Hawkesworth, Knt., Wm. Staveley, Thos. Ingilby, John Barney, Fras. Carlile, Roger Palmer, Geo. Burnett, Edmd. Mawde, Richd. Smith, Wm. Batty, Wm. Caldwell. v. Michael Askwith, James Moore.: Manors of Ripon, Otley, Cawood, and Wistow, in possession of Toby Archbishop of York, in right of his archbishoprick. Privileges and jurisdiction within the liberties of said archbishopric. Whether the freeholders”in regard of suit and services within sd liberties


under seige three times. “

Additional information is provided by the UK at http://www. lichfield.gov.uk/cathedral-early.html

“Although only Bishop for three years, Chad converted many to Christianity and after his death he remained a popular figure inspiring many miracles.

“From 700 his body was interred in a Saxon cathedral which lies beneath the present building. In the latter years of the 11th century a Norman building began to replace the Saxon one and a few pieces of the Norman stonework are still visible in Consistory Court.

“At about the same time Bishop de Clinton fortified the Close and laid out the City to cater for the pilgrims visiting the shrine of St Chad. Within a century, however, work began on the Gothic cathedral, which we see today. The Choir dates from 1200, theTransepts from 1220 to 1240 and the Nave was started in 1260.

“Through the next hundred years, additions were made, including the Vestibule which leads from the north Choir Aisle to the Chapter House and contains a unique medieval pedilavium where, following the example of Jesus at the Last Supper, feet were washed on Maundy Thursday.

“The octagonal Chapter House, which was completed in 1249 and is one of the most beautiful parts of the Cathedral with some charming stone carvings, houses an exhibition of the Cathedral’s greatest treasure, the Lichfield Gospels, an 8th century illuminated manuscript.

“In 1285 the nave was rebuilt and then the Lady Chapel, completed in 1330, was built to contain the shrine of St Chad. Today it contains the 16th century Herckenrode glass.

“During the English Civil


tithes, and 21s. from offerings); the vicar, however, also received an annual payment of £3 6s. 8d. from the lords of Newhall (presumably in lieu of tithes). In 1650 the church was worth £43 6s. In 1665 the vicar still claimed all the small tithes, but by 1668 Cauldwell paid a modus of £6, as did Stanton and Newhall by 1693. The Cauldwell modus was evidently disputed, but was confirmed in 1676 by an agreement which required the vicar to preach once a month at Cauldwell. In 1707 the vicar received £31 from glebe and tithes and £12 3s. from moduses, together with Easter offerings, fees, and small rents. Owen Lloyd (vicar 1768-1813) disputed the Cauldwell modus in 1773, and by decision of the House of Lords in(1 virgate) whereas the average holding of a rent-payer is about 30 acres (2 virgates) although one, Richard, has 60 acres (4 virgates). The rent-payers are relatively ‘free’ men – ie free of obligation to the lord. The reference to the total land area as ‘40 and 9 virgates’ (XL & IX) may indicate two physically separate blocks of land.

The second survey shows that there were 26 virgates cultivated by the men, although they were assessed for tax as 20 virgates. There were 11 virgates of land cultivated by the villeins for customary service alone (although one of them was shared), 6 for a mix of service and rental (Godwinus and Algarus), and nine virgates were just rented. The Abbey, like any other landlord, had to provide men


although not named individually were clearly key workmen, looking after the plough-teams and carrying out the ploughing. They had five acres of land each (second survey).

The Priests
In each of the two Burton surveys, a priest is listed working land along with the other tenants. These are exactly the worker-priests as described by David Parsons for the time of Domesday (see In Focus 6). It could be that these two priests, Roger in the first survey, and Godwin(us) in the second, were the Abbey’s bailiffs on the Appleby estate. Godwin seems to have been a local man who was priested between the two surveys. He in particular would have known the other men well and been able to list their names.

During the 12th century the establishment of local churchesof enquiry are to be found in Appleby’s past. Of course, they were not intended as a means of measuring the village’s population, but, because they concerned the population as a whole, they can be used to make an estimate for the particular date of each enquiry. The accuracy of the population estimates will vary and depend upon the accuracy of the recorded information and the assumptions made in linking the information to the population count.

A second line of attack is to use the parish registers. From the late 16th century onwards, the parish priest or clerk recorded, more or less faithfully, the baptisms, burials and marriages which took place at the parish church. Most people were baptised, most marriages took place in church, all who died in


how many children were there under the age of 14 years anyway? Demographic historians differ in their answers to these questions but, if we assume 15% evasion and 40% under 14 years, the 1377 village population works out at around 180.

The Black Death

The population of England as a whole is thought to have risen from about 2 million at the time of the Domesday Survey up to a maximum of perhaps 6 million around the end of the 13th century. When the first outbreak of the Black Death (bubonic plague) occurred in 1348, a down-turn in population was already under way caused by climatic changes and over-exploitation of the land. There were particularly bad harvests in 1315, 1316, 1320 and 1321.

Between 1348 and 1377 the mortality caused byway along the present lane to Upper Rectory Farm on the south side. The name goes a long way back: the 15th century Glebe Terrier for Appleby Church (listed in Nichols) gives land on Berihill and nygh Berihill wey and again in Beryhill wey. Jill Bourne tells us that the word element bere is Old English for ‘barley’. (Indeed the clock tower area in the centre of Leicester was from the 13th century known as Berehill ie ‘barley hill’). Appleby has other crops recorded among its field names, eg Rye Croft and The Oat Hills. Barley was of course grown extensively for use in production of beer. As G M Trevelyan so graphically put it: ‘Saxon and Dane each came from a thirsty race, and many an acre


No Mans Heath. Also, the old county boundary line between Leicestershire and the detached part of Derbyshire, radiating from the same point, separated the two manors of Appleby Parva and Appleby Magna, the constituent halves of Appleby parish from medieval times. To the south east, this group of parishes also joins smoothly on to the parish of Twycross, encompassing settlements at Norton juxta Twycross, Gopsall, Twycross and Orton on the Hill. No other contiguous parish joins smoothly to this larger group, which appears complete in itself. Each internal boundary meets the peripheral boundary in a ‘T’ junction, a feature which Jill Bourne has pointed out is ‘a characteristic indicator of being arbitrarily drawn’. The group must therefore be considered to be a serious candidate for the multiple estateis a suggestion of an earlier territorial grouping across our supposed multiple estate, in that the Saxon Countess Godiva ‘held’ Norton-juxta-Twycross and most of Appleby Parva as well as leasing part of Burton Abbey’s land at Appleby Magna (the past tense ‘held’ signifies that her land was confiscated). Her only other holding in Leicestershire was at Bilstone. This occupies an indentation in the boundary adjacent to Twycross and Gopsall (and part of the modern civil parish of Shackerstone). So perhaps Godiva’s pre-Conquest holdings represent the remnant of a Saxon multiple estate, identified by its boundaries and in which Bilstone should be included.

As we have seen, the only priest mentioned in Domesday Book for the area covered by these parishes was at Norton juxta Twycross and this location would


comrades, who in turn were swept away and drowned when attempting to cross the swollen waters of the River Aire.

“In Winwoed field was amply avenged the blood of Anna, the blood of the kings Egric, Oswald and Edwine.” Soon after this great victory Oswin sent his little daughter Ethelfleda to the monastery over which presided the sainted Hilda, whilst the lands and other goods he gave were the means by which the noble abbey was built on the summit of the cliff overlooking Whitby.

Near to Whinmoor is a place known to this day as “Hell’s Garth”. Tradition says that on this spot thousands of the slain were buried.

Wheater – 1882

http://www.oldtykes.co.uk/dabatt.htm

Oswald, King of Northumbria, was from the Bernician dynasty which lived north of the Tees. King Edwin, who diedthe Indian market currently."Amazing visit to Airbus facility. They are very enthusiastic about the 'Make in India' initiative," the prime minister eventually tweeted. He had arrived at the campus straight after landing here from Paris on a Boeing 747-437 aircraft of 1996 vintage.The occasion also saw the Airbus top brass give its assessment on the need for aircraft by Indian carriers. The country, it said, will require as many as 1,291 planes over the next 20 year -- 913 in single-aisle configuration, 322 twin-aisled and 56 large ones. "Every A320 family plane is now partly made in India," read another large billboard, as the prime minister was taken on the tour by a team led by Airbus Group chief executive Tom Enders, who said his group was keen


on forging a stronger industrial bond with India."India already takes centre-stage role in our international activities and we want to even increase its contribution to our products. We support Prime Minister Modi's 'Make in India' call and are ready to manufacture in India -- for India and the world," Enders said.A visibly pleased Modi was informed that the Airbus procurement from India was set to grow further as it planed additional manufacturing and engineering work packages with local firms and accelerate their integration into the group's global supply chain.Such partnership, the group added, will extend to a host of areas such as engineering, pilot training, customer services and maintenance, repair and overhaul capability, or MRO, with Indian partners.In India, the $65-billion Airbus Group already operates two engineering centres:This invention relates to nucleic acid and amino acid sequences of two delta-6 desaturase homologs and to the use of these sequences in the diagnosis, treatment, and prevention of cardiovascular diseases, disorders of aging, disorders of fatty acid metabolism, and cancer.
Fatty acid desaturases catalyze the elongation and desaturation of the physiologically important hydrocarbon chain molecules known as fatty acids. Fatty acids are lipophilic modifiers of proteins, fuel molecules, insulating materials, and precursors to hormones including the prostaglandins, which are active in pyrogenesis, vasodilation, vasoconstriction, and pain reception. Phospholipids and glycolipids that compose cell membranes are made from fatty acids. Mammals derive unsaturated fatty acids from the unsaturated 16-carbon palmitate or diet-derived linoleate and linolenate, which are desaturated at two and three points, respectively. In eukaryotes, a variety of


acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:3, a fragment of SEQ ID NO:1, and a fragment of SEQ ID NO:3.
The invention also provides a method for detecting a polynucleotide encoding the polypeptide comprising the amino acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:3, a fragment of SEQ ID NO:1, and a fragment of SEQ ID NO:3 in a biological sample containing nucleic acids, the method comprising the steps of: (a) hybridizing the complement of the polynucleotide sequence encoding the polypeptide comprising the amino acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:3, a fragment of SEQ ID NO:1, and a fragment of SEQ ID NO:3 to at least one ofKnocking/Sea Cruise" (Little Richard/Huey Smith) – 4:11
  "Shake, Rattle and Roll" (Charles E. Calhoun) – 5:05
  "Rambling on My Mind" (Robert Johnson) – 7:21
  "One Night of Sin" (Dave Bartholomew, Pearl King, Anita Steiman) – 2:52
  "Steady Drivin' Man" (Willy DeVille) – 6:03
  "Goin' Over the Hill" (Fred McDowell) – 3:26
  "Bamboo Road" (Willy DeVille) – 5:45
  "Who's Gonna Shoe Your Pretty Little Foot" (traditional) – 5:03
  "Carmelita" (Warren Zevon) – 4:41
  "All by Myself" (Dave Bartholomew, Fats Domino) – 3:10
  "Billy the Kid" (Bob Dylan) – 5:08

Note: The concert in Stockholm cannot have been on June 24, 2002, because Willy DeVille performed at the Metropol in Berlin on that day (cf. the 2009 double DVD The Legendary Berlin Concerts - In Memoriam 1950-2009 (e-m-s


the information there is on HPV warts. At my appointment, the doctor confirmed my suspicion and did the first of several procedures to remove them. She also told me that it was not likely I got it from my new partner as the timeline of their appearance was too short.

Afterward, I spent hours on the phone with my mom, crying, and worrying about how to tell my partner. The internet had told me awful things. I read endless horror stories about people who had warts for years without relief, people whose partners rejected them and people who could not find new partners willing to take on a person with a treatable, but not always curable, STI. I thought my life was over, because these voices had told metheirs were.

Here’s the thing: the worst part of contracting an STI is not the actual health problems, because with good medical care they are easily dealt with. However, when you are faced with this simple and realistic aspect of pursuing a life of sexual fulfillment, all the stigma you have comes right to the surface, and you can never be prepared for how much there is. And not just stigma about being “dirty.” For so long I had been using my sexuality and men as a way to feel my beauty and self-worth. So when my picture of my sex life became compromised, I instantly felt unworthy, unlovable, undesirable, and unmasked.

After a week of hour-long phone calls, my mother said “I think maybe you should see someone about


to the horizontal once again when you reach your final position above the arena. She said the essence of acrobatics is the transition between horizontal to vertical. Doing it in a seamless way. Doing it in a beautiful way.

Her remarkable passion explained one of the primary tools of script analysis: Find the transitions.

There is a tendency to get lost in a script, in a role, in a single speech. The words become the forest that keeps us from seeing the trees.

On a macro scale, look for the moments that change the direction of your character. On a micro scale, look for the moments in each line where there is a transition. Where is the place you learned something you didn’t know before? What is the one piece of+ -11. Let o = w - 1. Let y = 3 - 3.1. Which is the closest to o?  (a) 3  (b) y  (c) 5
b
Let n = 0 - -16. Suppose -n = -2*o - 5*q, 2*o + 7 = o + 5*q. What is the closest to o in 0.1, -2, -5?
0.1
Suppose 4 = q + 2. Let z be 1 - (16/(-10) + q - -1). What is the nearest to 0 in z, 1/3, -5?
1/3
Let h = 75 + -55.6. Let p = h - 19. Which is the nearest to 0?  (a) 1  (b) p  (c) 2
b
Let v = 393 + -389. Let j = -0.3 + -0.2. What is the nearest to -0.5 in j, v,


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    returnassociated track section for detecting occupancy, for communicating signal control rate codes through the track rails and for detecting broken down insulated rail joints which may be used to define boundaries of the several track sections. The alternating current is generally a 100 HZ frequency which is continuously modulated by a code generator to provide time spaced square wave track circuit pulses of 100 HZ alternating current at selected rates of 75, 120 or 180 time spaced pulses per minute. The generating of the square wave pulses tends to generate undesirable harmonics, and the relatively slow 75 rate code is difficult to decode. Phases of the adjoining track circuits are staggered in order to guard against broken down insulated rail joints.
An object of the present invention is to


151 B.R. 952 (1992)
In re Robert K. GIDLEY & Nita M. Gidley, Debtors.
Robert K. GIDLEY & Nita M. Gidley, Appellants,
v.
UNITED STATES of America, Appellee.
No. 92-0349-CIV-ORL-18.
United States District Court, M.D. Florida, Orlando Division.
November 2, 1992.
B. Gray Gibbs, Foley & Lardner, Tampa, FL, for appellants.
Richard A. Resnick, U.S. Justice Dept., Tax Div., Washington, DC, for appellee.

ORDER
G. KENDALL SHARP, District Judge.
On June 12, 1990, Robert K. Gidley and Nita M. Gidley (Gidleys) filed a petition for relief under Chapter 7 of the Bankruptcy Code. In their schedules, the Gidleys listed the Internal Revenue Service (IRS) as a creditor based on unpaid tax liabilities for 1982 through 1986. The Gidleys received their discharge in September 1990. On November 20, 1990, the IRS, on behalf of the United States, filed a proof ofruling of a bankruptcy court "unless its factual findings are clearly erroneous or it applies the incorrect legal standard." See Cox v. Landsdowne (In re Cox), 904 F.2d 1399, 1401 (9th Cir.1990); accord In re Fielder, 799 F.2d at 657.
Section 523(a)(1)(A) of the Bankruptcy Code provides that a discharge does not discharge a debtor from any debt for a tax of the kind specified in section 507(A)(7). See 11 U.S.C. §§ 523(a)(1)(A), 507(a)(7)(A)(i) (1988). Section 507(a)(7)(A)(i) excepts from discharge "a tax . . . for a taxable year ending on or before the date of a filing of a petition for which a return, if required, is last due, including extensions, after three years before the date if the filing of the petition." The issue on appeal is


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