  address = address.replace('ave', '')
                address = address.replace('avenue', '')
                address = address.replace(' sixth', ' avenue of the americas')
            if ' 6th a' in address:
                address = address.replace('ave', '')
                address = address.replace('avenue', '')
                address = address.replace(' 6th', ' avenue of the americas')
running out of file handles (default limit is 1024 for regular users) which you can check by running grep 'open' /proc/<webapp pid> for limit and ls -1 /proc/<pid>/fd | wc -l for currently open file handles.
I think your code is not sending a correct response which is causing the connections to remain open, eventually running out of open file handles (an open socket is a file on posix systems).
Can confirm what state the connections are in with netstat -an | grep <webapp port> when you see the issue. It should have a list of 1k+ IPs and ports and their state.
Would guess they are in TIME_WAIT state which is indicating the client is not closing the connection correctly and it is left up to the kernel to


birth of their first child. They thought about renovating, but the cost to expand was incredibly high, and the footprint of their Capitol Hill row house was limited anyway. Their neighborhood, however, is commanding very high rents. “We ran the numbers. I literally made a spreadsheet and ran all the different options,” said Liz, who purchased the Capitol Hill home several years ago, before she was married. “It made the most financial sense for us to keep our house in D.C., rent it out and buy here.”

Liz and Kevin bought a larger home with a big yard just outside D.C. in Cheverly, Maryland. She says many of their friends are doing the same thing as their families expand. “It was great for us because we were going toThings NOT To Do In Sweden

5 Things NOT To Do In Sweden

published:29 Apr 2018

views:694237

In this video I discuss the top 5 things not to do in Sweden after having lived here the past 9 months.
Check Out The Blog Post: https://lagomlifeapparel.com/blogs/swedish-culture/things-not-to-do-in-sweden
My Instagram: https://www.instagram.com/stefanthyron/
Song: Jarico - Landscape (Vlog No Copyright Music)
Music promoted by Vlog No Copyright Music.
Video Link: https://youtu.be/EwRdKJURDHw...

5 Things NOT To Do In Sweden

published:29 Apr 2018

views:694237

In this video I discuss the top 5 things not to do in Sweden after having lived here the past 9 months.
Check Out The Blog Post: https://lagomlifeapparel.com/blogs/swedish-culture/things-not-to-do-in-sweden
My Instagram: https://www.instagram.com/stefanthyron/
Song: Jarico - Landscape (Vlog No Copyright Music)
Music promoted by Vlog No Copyright Music.
Video Link: https://youtu.be/EwRdKJURDHw...

15 Things You Didn’t Know About Sweden

published:29 May 2018

15 Things You Didn’t Know About Sweden

15 Things You Didn’t Know About Sweden

published:29


people working thirteen/fourteen hour days driving a bus through the city. In this day and age, it's pretty awful to be honest."

Additionally, he said that drivers can still be driving up to five-and-a-half hours without a break.

"Regrettably, in Wellington, only one company - Mana Coach Services - is fully compliant with the legislation."

The Employment Relations Amendment Act was introduced in 2018 to give employees more say over when they want to take their breaks.

Charles McGuinness, head of Wellington-based McGuinness Employment Law, said it makes things stricter.

"If there is no agreement between the employee or employees, and employer, then there are mandatory set requirements for rest periods and meal breaks. And so the legislation is very prescriptive about when those breaks must be taken and how payment is toASB warns customers of POLi 'spoof'

JASON KRUPP

Last updated 11:11 19/12/2012

Relevant offers

ASB is warning customers against using the POLi website, saying the popular online payment service is spoofing its secure website and the Bank Direct website, which could potentially leak customer information.

The bank said its fraud monitoring operations discovered that when customers wanted to make a payment through a POLi-affiliated website, it was presented with what appeared to be a genuine ASB FastNet Classic and Bank Direct NetDirect website, and asked to log on.

However, these were POLi's identical spoofs or mirrors of the actual site, which captured the security details and logged on to the site on behalf of the customers to complete the transaction.

"Note that these are not our secure websites and we are unable to audit the


12-hour light/12-hour dark cycle and fed an autoclaved diet with ad libitum access to standard rodent chow (LabDiet, 5001) during the study period. After 2 weeks of acclimatization, animals were randomly divided into 3 equal groups consisting of 7 animals each: (1) Control group: distilled water was administered by gavage daily from day 1 and 0.9% saline was administered by intraperitoneal (ip) injection on days 1, 8, and 15; (2) Cisplatin group: cisplatin (5 mg/kg of body weight) was administered by a single ip injection to induce cisplatin toxicity on days 1, 8, and 15 with distilled water administered by gavage in the same volumes; And (3) Cisplatin + D-methionine group: D-methionine was diluted in phosphate-buffered saline (PBS) and administered by gavage at 300 mg/kg weight/day per rat.calculated using the following formulas:

$$\begin{array}{l}
{Relative\ kidney} \\
{{weight} = \ \left\lbrack \begin{array}{l}
{{weight\ of\ the
kidney}\left( g \right)/} \\
{\ {body\ weight}\left( g \right)} \\
\end{array} \right\rbrack \times 100\%} \\
\end{array}$$

$$\begin{array}{l}
{Feeding} \\
{\ {efficiency}\left( \% \right) = \left\lbrack \begin{array}{l}
{{body\ weight
change}\left( g \right)/} \\
{{food\ intake}\left( g \right)} \\
\end{array} \right\rbrack \times 100\%} \\
\end{array}$$

All animal experimentation procedures were conducted according to the Affidavit of Approval of Animal Use Protocol, Chung Shan Medical University Experimental Animal Center, Taichung, Taiwan (Approval No. 1439).

Biochemical Blood Analysis {#section5-1534735417753543}
--------------------------

Urea, creatinine, and triglycerides were determined in the serum by colorimetry using a commercial kit (Randox Laboratories Ltd, Crumlin, UK), according to the manufacturer's protocols. Serum Na, K, and uric acid analyses were performed on automatic analyzer (ADVIA 1800, Siemens, Malvern, PA).

Oxidative Stress and Antioxidant Enzymes in Kidney Homogenate Analysis {#section6-1534735417753543}
----------------------------------------------------------------------

Thiobarbituric acid reactive substances resulted


 16.1 ± 1.5
  Hematocrit (%)        50.2 ± 2.1      45.5 ± 6.0                                                             50.6 ± 3.6
  MCV (fL)              60.7 ± 1.5      57.9 ± 1.0^[\*](#table-fn7-1534735417753543){ref-type="table-fn"}^     62.3 ± 1.7^[\#](#table-fn8-1534735417753543){ref-type="table-fn"}^
  MCH (pg)   decreasing VEGF levels in blood.

As mentioned above, antioxidants are considered effective for ameliorating cisplatin-induced nephrotoxicity. Cisplatin contributes to the significant increase in renal MDA, a marker of lipid peroxidation, and decrease in CAT activity.^[@bibr23-1534735417753543],[@bibr55-1534735417753543]^ In addition, cisplatin decreases glutathione levels in kidney.^[@bibr57-1534735417753543]^ Hence, an imbalance in the antioxidant defense system impairs renal function. The present results demonstrated that D-methionine improves cisplatin-induced oxidative stress events as indicated by suppression of MDA levels, slightly elevated GSH concentration, and catalase activity in kidney homogenate ([Figure 2](#fig2-1534735417753543){ref-type="fig"}). Methionine maintains GSH concentration in kidney cortices.^[@bibr58-1534735417753543]^ In addition, D-methionine may act as a sulfur-containing nucleophile and has metal chelating property for scavenging free radicals.^[@bibr12-1534735417753543],[@bibr59-1534735417753543]^ Moreover, previous studies have demonstrated the antioxidative properties of D-methionine in cisplatin-induced adverse effects.^[@bibr24-1534735417753543],[@bibr25-1534735417753543]^ Together, these results suggest that D-methionine


significant decrease in triglyceride serum levels.^[@bibr23-1534735417753543]^ We speculated that the effects of cisplatin on triglyceride changes are dose and time dependent.^[@bibr49-1534735417753543]^

In addition to D-methionine, some low-molecular-weight compounds have also been shown to be effective at reducing the side effects of cisplatin, such as sodium thiosulfate,^[@bibr62-1534735417753543],[@bibr63-1534735417753543]^ N-acetyl-L-cysteine,^[@bibr64-1534735417753543]^ and others chemoprotective agents.^[@bibr65-1534735417753543]^ Furthermore, the fortification of plasma with pure plasma proteins has been shown to offer some protection against the toxic effects of cisplatin.^[@bibr43-1534735417753543]^

In conclusion, D-methionine has been recommended for decreasing the ototoxicity of cisplatin. In this study, we found that the chemopreventive efficacy of D-methionine includes improved appetite, weight gain, and attenuated nephrotoxicity through elevation of antioxidative activities in a chronic repeated dosing model. Our results support the use of D-methionine as a chemoprotectant during chemotherapy.

**Declaration of Conflicting Interests:**Download Layered Popups for WordPress v5.99| Codecanyon Premium WP Plugin.Its the fastest Popup WordPress Plugin. With this plugin you can realize your imagination and make unique multi-layers animated popups. You can embed AJAX-ed subscription/contact form which works with 62 email marketing providers and collect leads.

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10% in Very Remote areas. In addition, the proportion of full-time doctors who worked 50 hours or more a week increased with remoteness from 58% in Major Cities to 75% in Very Remote areas. Consistent with these longer hours, and with other factors, including the higher proportion of doctors in Major Cities who are salaried hospital staff rather than private practitioners, doctors’ incomes tended to be higher in areas outside of Major Cities. In Major Cities, 58% of doctors earned $1,500 or more per week, compared with 81% of doctors in Very Remote areas.

There were also demographic differences between doctors in different geographic areas. People aged less than 35 years made up 17% of doctors in Inner and Outer Regional areas compared with 27% in Major Cities andOn March 14th, shortly after the @Alt_uscis account started tweeting, agent Adam Hoffman of the US Customs and Border Protection (CBP) faxed Twitter a summons, ordering them to produce records from the account. Curiously, the summons "ordered Twitter to produce the records to a CBP office in Washington D.C. by 11:45 A.M. on March 13, 2017 -- the day before the CBP Summons was faxed," according to the legal complaint filed by the social media titan (embedded below).

Twitter's suit is a twofold resistance to the government's disclosure request, opposing both the method and the nature of demanding these particular identities. First, it openly attempts to block the Department of Homeland Security and CBP from "unlawfully abusing a limited-purpose investigatory tool to try to unmask the real identity of


junction. OCFs should be suspected in all patients sustaining high-energy blunt trauma to the head and/or upper cervical spine, resulting from axial loading, lateral bending and/or rotation, and/or direct blow. Besides a CT study assessing potential intracranial injuries, these patients require CT of the craniocervical junction. Radiologists should be aware of the types of OCFs and associated injuries.how it can work:
function callback (res, callback) {
    res.on('data', function(chunk) {
        buf = new Buffer(chunk);
        console.log('data length: ' + buf.length);

        // Make sure the argument is indeed a callable function
        if (typeof callback === 'function') {
            callback(buf);
        }
    });
}

Now what you do is simply implement a callback, that is executed when the result is finished.
var client = require('./sender');

//envoyer le paquet au seveur blizzard.com
client.sendAndreceive(bufenc, function(received) {
    console.log('Received', received);
});

This JavaScript pattern is called the


and *q*~E~, was similar for both systems, indicating that no reduction in sorption efficiency was observed for the six performed sorption-desorption cycles. Ratios of capacities for Pb and Zn in the (Pb + Zn) system and for Cd and Zn in the (Cd + Zn) system in breakthrough overlap with Pb/Zn and Cd/Zn concentration ratios in the feeding solutions, confirming simultaneous binding up to breakthrough. Ratios of capacities in exhaustion are higher than the Pb/Zn and Cd/Zn ratios, indicating better binding of Pb and Cd compared to Zn, as well as the displacement effect. These results are in correspondence with the results obtained for the (Pb + Zn) system at zeolite bed depths of 4 and 12 cm \[[@B41-ijerph-16-00426]\].

3.2. Analysis of the Regeneration Curves in the Binary (Pbzeolite layer was achieved earlier, after *t*~R~ ≈ 5--8 h with the consumption of a smaller amount *V*~R~ ≈ 0.31--0.49 L of the NaNO~3~ solution ([Table 2](#ijerph-16-00426-t002){ref-type="table"}), confirming higher affinity toward Pb. This can be explained by the fact that Pb, due to the smaller hydrated ionic radius compared to Cd and Zn, can easily access the harder available sites in the zeolite structure. Its desorption is, therefore, more difficult and takes a longer time and a higher volume of the regenerating agent \[[@B39-ijerph-16-00426],[@B56-ijerph-16-00426]\]. Regeneration was very fast, and resulted in up to ≈5--13 times smaller volumes of effluents compared to the volumes of heavy metal solutions treated in the service cycles. Thus, the recovery of Pb, Cd, and Zn concentrations was very high. This enables their removal


flow of the solution through the column (m^3^/min), *A* is the cross-sectional area of the column (*A* = 0.00011304 m^2^), *ρ* is the density of water at 25 °C (*ρ* = 997.13 kg/m^3^), and *ε* is the fixed bed porosity (-).

All calculated parameters are listed in [Table 3](#ijerph-16-00426-t003){ref-type="table"}.

The obtained *K*~a~ values in [Table 3](#ijerph-16-00426-t003){ref-type="table"} and, therefore, the overall mass transfer are higher in the (Cd + Zn) system compared to the (Pb + Zn) one for the same experimental conditions. The reason for this is probably much less pronounced competition between Cd and Zn ions in the (Cd + Zn) binary system compared to Pb and Zn in the (Pb+ Zn) binary system, due to similar physicochemical properties of Cd and Zn ions. The mass transfer of Znbound in a significantly larger amount compared to zinc, although this is an equimolar solution with the same initial lead and zinc concentration. This confirms the higher affinity of lead compared to zinc. The content of exchangeable cations Na, K, Ca, and Mg is much lower than in the raw zeolite sample analyzed in our previous study \[[@B53-ijerph-16-00426]\], which can be attributed to the exchange with Pb, Cd, and Zn ions. In addition, the EDS analysis of the same zeolite sample milled to powder obtained a semi-quantitative elemental composition similar to that on the particle surface \[[@B42-ijerph-16-00426]\] with the dominant Pb content relative to the other exchangeable cations, confirming that the ion exchange is the main mechanism of ion binding and takes place within the whole zeolite particle


Note: *V*~B~, *V~E~*: the volumes of the solution treated until breakthrough and exhaustion, respectively; *t~B~*, *t~E~*: the service time in breakthrough and exhaustion, respectively; *q~B~*, *q~E~*: the capacities in breakthrough and exhaustion, respectively; *η*: the column efficiency; \* Results from \[[@B43-ijerph-16-00426]\].

ijerph-16-00426-t002_Table 2

######

The parameters of regeneration cycles for the (Pb + Zn) and(DDR4)

2 Ã— 8 Ã— 8 GiB 9 TiB (DDR4)

72 Ã— 2 Ã— 8 Ã— 8 GiB

Full System

Astra comprises 36 racks for a total of 2,592 compute nodes and 5,184 processors. The overall interconnect design is a three-level fat tree with a 2:1 tapered fat-tree at L1. The 36 racks comprise 648 chassis and 108 L1 switches. There are 3 540-port switches. Those are formed from 30 level 2 switches that provide 18 ports each (540 in total) with the remaining 18 links going for each of the 18 level 3 switches.

With a switch per 6 chassis (24 ports), the remaining 12 ports are used to link into the L2 switches, 4 links per 540-port switch.

With a little over five thousand cores, Astra will have a peak theoretical performance


Pages

Tuesday, May 17, 2011

Abercrombie & Fitch Co. (NYSE: ANF) is scheduled to release first-quarter earnings before the opening bell on Wednesday, May 18, 2011. Analysts, on average, expect the company to report earnings of 12 cents per share on revenue of $825.64 million. In the year ago quarter, the company reported a loss of 13 cents per share on revenue of $687.80 million.

Abercrombie & Fitch Co., through its subsidiaries, operates as a specialty retailer of casual apparel for men, women, and kids. Abercrombie & Fitch Co. (A&F) through its subsidiaries, is a specialty retailer that operates stores and direct-to-consumer operations. At the end of the first quarter, the Company operated a total of 1,071 stores. The Company operated 316 Abercrombie & Fitch stores, 181 abercrombie kids stores, 502the east") that was on display. On that day, I learned a valuable lesson that has served me well since: players love in-game parties. Every single time I run one, it is a hit. Additionally, the whole idea of this kind of mission is so different that it is very refreshing and can really energize a campaign.

The Evil Sword: I love Bane of the Shadowborn, an old 2e Ravenloft adventure about an evil sword named Ebonbane. It could animate weapons, including the ones the heroes had! It was so different. All these hovering knives just slicing and flying around as the group's own weapons turned against them. You have to be careful with things like this because players definitely feel weird about it. It has a bit of


is rather limited. A recently published review identified four studies on relevant educational interventions that described their content,^[@R21]^ included control groups, and conducted both a pre-test and a post-test in order to evaluate their effectiveness.^[@R22]--[@R25]^ To our knowledge, one more study not included in that review also meets the abovementioned sound criteria.^[@R21],[@R26]^

The studies were conducted in different countries: Australia,^[@R22]^ Germany,^[@R23],[@R26]^ Hong Kong,^[@R24]^ and USA.^[@R25]^ The number of participants varied, ranging from 40 to 457.^[@R22],[@R25]^ The studies aimed to change conceptions about mental illness,^[@R25]^ to change negative attitudes,^[@R24]^ to reduce the stigma towards mental illness,^[@R22],[@R23],[@R26]^ and to increase the level of knowledge about mental illness.^[@R22]^ Furthermore, some studies also aimed to improve help-seeking and to promote participants\' mental health.^[@R22],[@R23],[@R25],[@R26]^ Most of the interventions provided factual information about mental illness,at one school were assigned to the intervention (n=86) and participants at the other school were assigned to the control group (n=75). The sample characteristics of the two groups are shown in [Table 1](#T1){ref-type="table"}. The two groups did not differ significantly according to sex, previous contact with people with mental illness, and mental health awareness, all of which have been shown to be associated with attitudes towards the mentally ill. Assessments were carried out 1 week prior to and 1 month after the end of the intervention (*i.e.* 2 months after the baseline assessment). Adolescents who did not complete the follow-up assessment did not differ significantly from those completed both two assessments in terms of all variables under study at baseline assessment. Adolescents were asked to complete the


odpowiednim skrotem
		elseif strpart(getline('.'), col('.') - 8, 7) =~? '[0-9IVXLCM]\s\+\(r\|w\)\.[^a-z±æê³ñó¶¿¼]\{-}$'
			s/[0-9IVXLCM]\zs\s\+\ze\(w\|r\)\.[^a-z±æê³ñó¶¿¼]\{-}\%#/\~/ei
			exe 'normal '.s:col.'|'
			if s:col == s:linelength
				startinsert!
			else
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			endif
			return ' '
		" Wstaw tylde miedzy liczba a miara, itd.
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			s/\(\d\|mln\|mld\|tys\.\)\zs\s\+\ze\(z³\|gr\|ha\|m\|t\|mies\|godz\|min\|sek\|cm\|km\|mln\|mld\|tys\.\)[^a-z±æê³ñó¶¿¼]\{-}\%#/\~/ei
			exe 'normal '.s:col.'|'
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			return ' '
		" Rozwin myslnik w zbitkach w '\dywiz ':
		" bialo-czerwony -> bialo\dywiz czerwony
		elseif strpart(getline('.'), col('.') - 20, 19) =~? '[a-z±æê³ñó¶¿¼]-[a-z±æê³ñó¶¿¼]\{-}[^a-z±æê³ñó¶¿¼]\{-}$'
			s/[a-z±æê³ñó¶¿¼]\zs-\ze[a-z±æê³ñó¶¿¼]\{-}[^a-z±æê³ñó¶¿¼]\{-}\%#/\\dywiz /ei
			let colb = s:col + 6
			exe 'normal '.colb.'|'
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			else
				startinsert
			endif
			return ' '
		" Rozwin '--' miedzy liczbami w '\ppauza ':
		" 39--45 -> 39\ppauza 45
		elseif strpart(getline('.'), col('.') - 10, 9) =~? '[0-9IVXLCM]--[0-9IVXLCM]\{-}[^0-9IVXLCM]\{-}$'
			s/[0-9IVXLCM]\zs--\ze[0-9IVXLCM]\{-}[^0-9IVXLCM]\{-}\%#/\\ppauza /ei
			let colb = s:col + 6
			exe 'normal '.colb.'|'
			if s:col == s:linelength
				startinsert!
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			endif
			return ' '
		endif
		" Tu koncz komentowanie ostatniej sekcji
	endif
	return " "
endfunction

" vim:ft=vim:ff=unix:
is first energized, and then encouraged to release the negative energy, which is then replaced by positive intention and integrated with the joy of the present moment.

Because this work deals with changing repeated or life-long negative patterns, a single session is only an introduction. To create and reaffirm the necessary reprogramming, we suggest a package of either 5 or 10 sessions (depending on the level of blockage/history of case), as we chart the course of change in your thoughts, emotions, attitudes and outlook.

Your guardian angels are there for you to support you at any time you need!


and complex conjugation $\omega \in G$. We define functors $t_F :I^F \xrightarrow{} I^{t (F)}$ and $w_F: I^F \xrightarrow{} I^{\omega (F)}$ on objects and morphisms by: $$\begin{aligned}
t_F: \ \ &(i_z)_{z\in F} \mapsto (i_{t^{-1}(y)})_{y\in t(F)}, \hspace{1cm}  (\alpha_z)_{z\in F} \mapsto (\alpha_{t^{-1}(y)})_{y\in t(F)}, \\
w_F: \ \ &(i_z)_{z\in F} \mapsto (i_{\omega^{-1}(y)})_{y\in \omega(F)}, \hspace{.8cm} (\alpha_z)_{z\in F} \mapsto (\alpha^{\omega}_{\omega^{-1}(y)})_{y\in \omega(F)}.\end{aligned}$$ Let $\omega_i \in \Sigma_i$ be the permutaion given by $\omega_i(s)=i-s+1$. We define the natural transformations $$t'_F: G_X^{F} \Rightarrow G_X^{t(F)} \circ t_F, \quad  w'_F: G_X^{F} \Rightarrow G_X^{\omega(F)} \circ w_F,$$ to be the natural transformations which at $(i_z)_{z\in F} \in \operatorname{Ob}(I^F)$ are the unique maps making the diagrams $$\begin{tikzpicture}
\node(a){$\displaystyle\bigwedge_{z\in F} S^{i_z}$};
\node(b)[right of = a,node distance = 6cm]{$\displaystyle\bigwedge_{z\in F} A_{i_z}\wedge X$};
\node(e)[below of = a,node distance = 2cm]{$\displaystyle\bigwedge_{y\in t(F)} S^{i_{t^{-1}(y)}}$};
\node(f)[right of = e,node distance = 6cm]{$\displaystyle\bigwedge_{y\inD;X)$ be the realization $$\operatorname{THR}(A, D;X):= \operatorname*{colim}_{F \in \mathcal{F}} \operatorname{THR}(A,D;X)[F] ,$$ with the topology given by identifying the colimit with the ordinary geometric realization. The space $\operatorname{THR}(A, D;X)$ is in fact an $O(2) \times O(2)$-space, where the action by the first factor comes from the dihedral structure and the action by the second factor comes from the $O(2)$-action on $X$. We are interested in $\operatorname{THR}(A,D)$ with the diagonal $O(2)$-action.

Fixed points
------------

Let $\triangle: O(2) \to O(2) \times O(2)$ be the diagonal map. We wish to study the $O(2)/C_r$-space $\left(\triangle^*\operatorname{THR}(A, D; X)\right)^{C_{r}}$. The image $\triangle(C_r)$ is not normal in $O(2) \times O(2)$, but it is normal in $\triangle(O(2))$, hence we consider $\operatorname{THR}(A, D; X)^{\triangle(C_r)}$ as an $\triangle(O(2))/\triangle(C_r)$-space.

Let $C_r \mathcal{F}$ denote the full subcategory of $\mathcal{F}$ with objects $C_r\cdot F$ for $F\in


such that $j^c$ is an acyclic fibration.

Let $\mathcal{S}$ be a family of subgroups of $H$, that is $\mathcal{S}$ is a collection of subgroups closed under taking subgroups and conjugates. We say that a morphism of othorgonal $H$-spectra indexed on $\mathcal{U}$ is an $\mathcal{S}$-equivalence if it induces isomorphisms on $\pi^K_q(-)$ for all subgroups $K\in \mathcal{S}$ and all $q \in \mathbb{Z}$. The $\mathcal{S}$-equivalences constitutes the weak equivalences in the $\mathcal{S}$-model structure, see [@MM Chapter IV.6].

Pointset fixed point functors
-----------------------------

Let $K\leq H$ be a closed subgroup. If $\mathcal{U}$ is a complete $H$-universe, then $\mathcal{U}^K$ is a complete $N(K)/K$-universe. There are two fixed point functors which take an orthogonal $H$-spectrum indexed on $U$ and produce an orthogonal $N(K)/K$-spectrum indexed on $U^K$. We recall the fixed point functors in case of a normal subgroup$N$, see [@MM Chapter V.4] for details.

We define a category $\mathscr{J}_{H,N}^{U}$ with the same objects as $\mathscr{J}_{H}^{\mathcal{U}}$. The morphism spaces are the $H/N$-spaces of $N$-fixed points $$\mathscr{J}_{H,N}^{\mathcal{U}}(V,W):= \mathscr{J}_H^{\mathcal{U}}(V,W)^N.$$ The composition and identity restrict appropriately making $\mathscr{J}_{H,N}^{U}$ into a category enriched over $(H/N{\mathsf{Top}}_*, \wedge, S^0)$. Taking $N$-fixed points levelwise takes an orthogonal $H$-spectrum $X$ and produces a functor enriched over $(H/N{\mathsf{Top}}_*, \wedge, S^0)$: $$\operatorname{Fix}^N(X): \mathscr{J}_{H,N}^{\mathcal{U}} \to \mathscr{T}_{H/N}.$$ We have two enriched functors comparing the categories $\mathscr{J}_{H,N}^{\mathcal{U}}$ and $\mathscr{J}_{H/N}^{\mathcal{U}^N}$: $$\mathscr{J}_{H/N}^{U^N} \xrightarrow{\nu}\mathscr{J}_{H,N}^{\mathcal{U}}\xrightarrow{\phi} \mathscr{J}_{H/N}^{\mathcal{U}^N},$$ The functor $\nu$ takes an $H/N$-representation $V$ to the $H$-representation $q^*V$, where $q: H \to H/N$ is the quotient homomorphism. The functor $\phi$ sends a $H$-representation $V$ to the $H/N$-representation $V^N$, and it sends a morphism $(\alpha, x)$ to the fixpoints morphism $(\alpha^N,x)$. The functors $\phi$ and $\nu$


unit of the adjunction $(P_{\phi},U_{\phi})$. We have a natural transformation of fixed point functors $\gamma: X^N \to X^{gN}$ given as $$U_{\nu}(\overline{\gamma} ): U_{\nu}(\operatorname{Fix}^N(X)) \to   U_{\nu}U_{\phi}P_{\phi}(\operatorname{Fix}^N(X)) =P_{\phi}(\operatorname{Fix}^N(X)).$$

The orthogonal spectrum $\operatorname{THR}(A, D)$
--------------------------------------------------

We fix a complete $O(2)$-universe $$\mathcal{U}=\Big(\bigoplus_{\alpha \geq 0}\underset{n \geq 0}{\bigoplus} \ \mathbb{C}(n)\Big)  \bigoplus \Big( \bigoplus_{\alpha \geq 0}\bigoplus_{n \geq 0} \ \mathbb{C}(n) \oplus \mathbb{C}(-n)\Big).$$ Here $\mathbb{C}(n):={\mathbb{C}}$ with $\mathbb{T}$-action given by $z\cdot x=z^{n}x$ for $z\in \mathbb{T}$ and $x\in {\mathbb{C}}$. On the left hand side $\mathbb{C}(n)$ is the $O(2)$-representation with $\omega$ acting by complex conjugation. On the right hand side $\mathbb{C}(n) \oplus \mathbb{C}(-n)$ is the $O(2)$-representation with $\omega$ acting by $\omega(x,y)=(y,x)$. We see that $$\rho_r^*{\mathbb{C}(n)}^{C_r}= \left\{ \begin{array}{rl}
\mathbb{C}(\frac{n}{r}) &\mbox{ if $r \mid n$} \\
0  & \mbox{ otherwise,}
       \end{array} \right.$$ and $$\rho_r^*\left(\mathbb{C}(n) \oplus {\mathbb{C}}(-n)\right)^{C_r}=$X$. The third term in the triangle identifies with the $G$-equivariant derived $C_{p^n}$-geometric fixed points; see [@MM Prop. 4.17], giving the well-known isotropy separation sequence.

\[cofiber seq\] Let $X$ be a $O(2)$-cyclotomic spectrum. The triangle $$\operatorname{H}_{\boldsymbol{\cdot}}(C_{p^n}; X) \xrightarrow{} X_f^{C_{p^n}} \xrightarrow{R_n} X_f^{C_{p^{n-1}}} \to \Sigma \operatorname{H}_{\boldsymbol{\cdot}}(C_{p^n}; X) ,$$ is distinguished in the $G$-stable homotopy category.

The result follows immediately using the distinguished triangle (\[cof\]), the identification of $(\tilde{E\mathcal{R}} \wedge X)_f^{C_{p^n}}$ with the $G$-equivariant derived $C_{p^n}$-geometric fixed points and the $\pi_*$-isomorphism of $G$-spectra $(X^c)^{gC_p} \to X^{gC_p} \xrightarrow{T_p} X $.

\[G-equi\] Let $f: X \to Y$ be a map of $O(2)$-spectra. If both $X$ and $Y$ are cyclotomic and $f$ commutes with the cyclotomic structure maps, then $f$ commutes with $R$. If $f$ restricts to a $\pi_*$-isomorphism of $G$-spectra, then by induction using the distinguished


is $C_{p^n}$-free. It follows from the generalized Adams isomorphism [@May96 Chapter XVI, Thm. 5.4] that there are isomorphisms in the $G$-stable homotopy category $$E\mathcal{R}_+ \wedge_{C_{p^n}} X \xrightarrow{\sim} (E\mathcal{R}_+ \wedge X)_f^{C_{p^n}}$$ and under this isomorphism the inclusions of fixed points on the right hand side correspond to the $G$-equivariant transfers on the left hand side $$\begin{tikzpicture}
\node(a){$E\mathcal{R}_+ \wedge_{C_{p^n}} X$}; \node(b)[right of = a,node distance = 4cm]{$ (E\mathcal{R}_+ \wedge X)_f^{C_{p^n}} $};
\node(e)[below of = a,node distance = 2cm]{$E\mathcal{R}_+ \wedge_{C_{p^{n-1}}} X$};
\node(f)[right of = e,node distance = 4cm]{$ (E\mathcal{R}_+ \wedge X)_f^{C_{p^{n-1}}}.$};

\draw[->](a) to node [above]{$\sim$} (b);

\draw[->] (a) to node [left]{${\mathrm{trf}}$} (e);

\draw[->] (b) to node [right]{${\mathrm{incl}}$} (f);

\draw[->](e) to node [above]{$\sim$} (f);

\end{tikzpicture}$$ We obtain an isomorphism in the $G$-stable homotopy category $$\operatorname*{holim}_{{\mathrm{trf}}} E\mathcal{R}_+ \wedge_{C_{p^i}} X \xrightarrow{\sim} \operatorname*{holim}_{i\geq 1} \operatorname{H}_{\boldsymbol{\cdot}}(C_{p^i}; X),$$ and we can identify the left handg,node distance = 5cm]{$S(\mathbb{C}^{k+1})/S(\mathbb{C}^{k}) \wedge_{C_{p^n}} X$};

\draw[->](a) to node [above]{} (b);
\draw[->](b) to node [above]{} (c);

\draw[->](a) to node [left]{${\mathrm{trf}}_{\mathbb{T}}$} (f);
\draw[->](b) to node [left]{${\mathrm{trf}}_{\mathbb{T}}$} (g);
\draw[->](c) to node [left]{} (h);

\draw[->] (f) to node [below]{} (g);
\draw[->] (g) to node [below]{} (h);

\end{tikzpicture}$$ By induction it suffices to show that the outer right vertical map induces isomorphism after $p$-completion on the homotopy limit of the transfers $${\mathrm{trf}}: S(\mathbb{C}^{k+1})/S(\mathbb{C}^{k}) \wedge_{C_{p^n}} X \to S(\mathbb{C}^{k+1})/S(\mathbb{C}^{k}) \wedge_{C_{p^{n-1}}} X.$$ In order to identify the right vertical map, we first note the following general fact. Let $Y$ be a pointed $O(2)$-space and let $i: G \to O(2)$ be the inclusion. If we let $i(Y)$ denote the $\mathbb{T}$-trivial $O(2)$-space whose underlying $G$-space is $i^*Y$, then there is an $O(2)$-equivariant homeomorphism $$S(\mathbb{C})_+\wedge Y \xrightarrow{\cong} S(\mathbb{C})_+ \wedge i(Y), \quad (z,y) \mapsto (z,z^{-1}y).$$ Lemma \[dimension\]


considering the map $f: B \to *$. The estimate amounts to the following Lemma:

\[conn of mapping space\] Let $A$ be a pointed $H$-CW-complex and let $B$ be a pointed $H$-space. Then $$\operatorname{conn}(\operatorname{Map}_H(A,B)) \geq \underset{K\leq H}{\min} (\operatorname{conn}(B^K)-\dim(A^K)),$$ where $K$ runs through all subgroups of $H$.

Throughout this paper we will make use of the Equivariant Suspension Theorem, a proof can be found in [@Ad Theorem 3.3].

\[suspension\] Let $V$ be a finite dimensional orthogonal $H$-representation and let $A$ be a based $H$-space. The adjunction unit $$\eta: A \to \Omega^V \Sigma^V A$$ is $n$-connected, where $$n \geq \min \{2\cdot \operatorname{conn}(A^H)+1,\operatorname{conn}(A^K)  \mid  K\leq H\text{ with } \dim \ V^K >\dim \ V^H\}.$$

Finally, we will need the following lemma.

\[dimension\] Let $V$ and $W$ be finite dimensional orthogonal $H$-representations. There is a canonicalThe Story of a Soul on Google Books concerning this passage stating:

This story appears in a collection of readings called La Tirelire aux histoires by Madame Louise Belloc [...]

Wednesday, March 22, 2017

The whole point of education is that it should give a man abstract and
eternal standards, by which he can judge material and fugitive
conditions. If the citizen is to be a reformer, he must start with some
ideal which he does not obtain merely by gazing reverently at the
unreformed institutions. And if any one asks, as so many are asking: "What is the use of my son learning all about ancient Athens and remote
China and medieval guilds and monasteries, and all sorts of dead or
distant things, when he is going to be a superior scientific plumber in
Pimlico?" the answer


is the last
lie in hell.

The difference between Puritanism and Catholicism is not about
whether some priestly word or gesture is significant and sacred.
It is about whether any word or gesture is significant and sacred.
To the Catholic every other daily act is dramatic dedication
to the service of good or of evil. To the Calvinist no act
can have that sort of solemnity, because the person doing
it has been dedicated from eternity, and is merely filling
up his time until the crack of doom. The difference is
something subtler than plum-puddings or private theatricals;
the difference is that to a Christian of my kind this short
earthly life is intensely thrilling and precious; to a Calvinist
like Mr. Shaw it is confessedly automatic and uninteresting.
To me these threescore years and ten are the battle.
To the Fabian CalvinistCost-effective marketing, 80/20 rule and getting the biggest bang for small bucks. Working across marketing platforms to leverage effect.Some of us prioritise quality above all – some of us prioritise low cost – we believe that successful SMEs seek a balance in their marketing - having neither the budgets to afford the most expensive, nor the desire to be cheap – so we play the odds and guided by Pareto’s law we aim for an 80/20 balance – in this case 80% of the effect with 20% of the spend.

This may sound like a big ask – but compare with elsewhere – what is the cost comparison between mainstream technology e.g. cars, music systems, computers etc. and the very highest specs available? If you could have promotion categorized


2*w - 3*n - 9 for w.
6
Suppose -16*p = -2065 + 657. Suppose -p = 3*b - 103. Solve b*z - 23 = 3*r, -5*z - 5*r = -2*r - 17 for z.
4
Let o be (1/2)/(-21*(-12)/2016). Solve o*n + 3*g = 4*g - 28, -g = -5*n - 34 for n.
-6
Suppose 16*q = -12*q - 18*q. Solve 2*p - 111*c = -110*c - 5, -4*p - 4*c - 16 = q for p.
-3
Let w(q) = 2*q**3 - 9*q + 5. Let d be w(2). Solve 28 = 3*m - 4*l - d, -m + 2*l + 13 = 0 for m.
5
Let v be (-2)/5 - 66/(-15). Let r be 4*15/14*(-14)/(-12). Suppose -4*j = -r*p + 4*p - 8, -j + 4*p = 13. Solve -j*a + v*a -Soldiers use 'Aza al-Kafarneh as a human shield during an IDF operation in Beit Hanun, July 2006

'Aza al-Kafarneh, mother to two

I live in the al-Kafarneh neighborhood, next to the a-Nasser mosque in the center of Beit Hanun. My family has twenty-one members, eleven of them children. We live in a four-story building.

This morning [17 July], at about 6:00 in the morning, Israeli military forces with armored personnel carriers and bulldozers made an incursion into our neighborhood. I looked out the window and saw a bulldozer destroy the fence that separates our house from my uncle's house. Then an armored personnel carrier and bulldozer drove up to the house. The bulldozer continued into the house, knocking down the ground-floor wall on the way. All of us, twenty-one people, were


physics. This force has a very short range, on the order of 10$^{-15}$ m, and is mediated via the exchange of mesons. The short range of the strong nuclear force can be understood in terms of the uncertainty principle: the exchange particles are virtual and have a minimum energy equal to their mass, limiting the time over which these virtual particles can exist to roughly $\hbar / m$, and thus the maximum distance they can travel to $\hbar c/m$. This means that the lightest meson, the pion ($m_\pi$=140 MeV), provides the longest range component of the interaction with a range of order 1.5 fm. Exchange of a heavier meson, or multiple mesons, provide a stronger interaction at shorter ranges, including the strongly repulsive short range core of the nucleon–nucleoneven heard of nuclei or hadronic models of matter, and just tries to provide a quantitative understanding of the structure/spectrum of bound states and interactions of these bound states of quarks and gluons via Lattice, Dyson-Schwinger, etc... approaches to understanding QCD. The second group has never heard of QCD, quarks, or gluons, and just takes nucleons and parameterizations of their interactions as fundamental starting points. They can then calculate their bound states (nuclei) and interactions starting from the “fundamental properties” of nucleons (as determined by the calculations of the first group). The knowledge that went into generating the description of hadrons provides almost no *direct* constraints and surprisingly little insight into how nuclei are formed from the nucleons. For another take on this idea, I point the reader


physics (and beyond) learn about both, but treat one or the other as reality when making models or calculation, or when performing experiments using a table-top setup, a large facility, the universe itself, or a computer as their laboratory.

$<$rant$>$ I have to stop here and say two things about Lattice QCD. First of all, it is an amazing tool and one day, when it reaches the point where complete calculations using fully realistic input parameters become easy, it will replace most if not all of what is considered nuclear physics today - both theory and experiment. In the meantime, while lattice QCD is providing us more and more important glimpses into QCD all the time, I just hate it when people refer to lattice calculations as “experimental results.”difficult than probing protons and neutron. However, the pion is one of the simplest bound states of QCD, and it has tremendous impact on the formation of matter. As such, whatever we learn about the pion impacts both our understanding of QCD and “traditional” nuclear physics. Heavy mesons play little role in ordinary matter, but they provide a system where simplified models of QCD are more applicable, and anything we can learn about these heavy quark systems will provide information on QCD. While people involved in these measurements, and many others I haven’t mentioned, often focus on the direct impact of their experiments, this is a broad, cooperative effort to understand the physics that is responsible for the nature and form of the universe.

I’ve focussed here mainly on


or in fact where the hadronic picture becomes totally meaningless. While we can observe neutron stars and make models for the evolution of the universe in the first few seconds, it’s difficult to get much direct experimental information on these systems. Of course the ideal solution would be to study matter at such extreme conditions in the lab, where we can control the temperature and density and where we can perform detailed measurements. For extreme conditions of density, we’re talking about densities comparable to the densest neutron stars. We don’t know of any way to produce stable matter at these densities in the lab, and we’re not likely to get funding for *in-situ* studies, even on the nearest neutron stars. So it’s not clear how we could probeenergy) and hope that for a good, solid, head-on collision, in which a small fraction of that kinetic energy would be turned into heat, generating a small region with temperatures that could probe the region of this phase transition, and possibly form a quark-gluon plasma.

I won’t say any more about hadronic matter at high temperature and the quark-gluon plasma. The reader can see the contribution to these proceedings by Thomas Schafer, who discussed the theoretical aspects of “The Phases of QCD” far better than I could, while on the experimental side, each of the collaborations at RHIC has published a summary on their investigations[@rhic1; @rhic2; @rhic3; @rhic4].

QCD and Hadrons at Extreme Densities
------------------------------------

While high energy probes have revealed quarks and gluons as the fundamental constituents of matter, hadronic descriptions


nuclei. One of the main approaches is to look for a change in nucleon structure when it it placed inside of a nucleus. We know that at extremely high hadron densities, one goes from a hadronic state, where the quarks interact almost exclusively with the other quarks in the same hadron, to a quark state of matter where the identity of the hadrons is lost. The densities are a few or several times smaller than this in an ordinary nucleus, but this is still a relatively large density and the presence of an external color field – coming from the other nucleons – may slightly change the binding of the quarks compared to when the nucleon is in empty space. If the color interaction between quarks in differentalso take properties of a nucleus as determined from a purely hadronic model and look for deviations from this model. Experimentally, there are many cases where one can look for such deviations, and while any discrepancy with the hadronic description indicates a breakdown in the model, it may be able to fix the problem by improving the “mundane” nuclear physics input to the model, without resorting to some exotic quark effect. I’ll give a quick overview of these experimental efforts in the next section.

Going Through the Motions – A Quick History of Looking for Medium Modifications
===============================================================================

I’ll now give a quick history of the search for medium modification. Don’t let the title get you down, as we still have a hope for a happy ending after all. More importantly,


and a single knocked out proton, the A(e,e’p) reaction, one has a kinematically complete measurement, and can reconstruct the initial momentum and binding energy of the struck nucleon. To do this, one must assume that the electron interacted only with the struck nucleon, and that the nucleon did not interact with any other nucleons after it was struck (*i.e.* absence of final state interactions (FSIs)). One then defines the missing energy ($E_m$) and missing momentum ($P_m$) in terms of the difference between the total energy or momentum of the initial state, assumed to be the initial electron and a proton at rest, and the final state, the measured electron and proton. This missing energy and missing momentum then represent the initial binding energy and momentum of the struckunlike in the case of A(e,e’p) scattering, where one can measure the three-momentum.

In fact, the real world is again a bit more complicated. First, we want to probe high values of $p_\parallel$ to probe the high momentum tails. Therefore, we cannot neglect the $p_\parallel$ terms, and the equation becomes, $$\nu + M_A = \sqrt{M_N^2 + (q + y)^2} + \sqrt{M_{A-1}^2 + y^2}.
\label{eq:ydef}$$ where we have taken $y = p_\parallel$. More importantly, we have made a key assumption here, that the residual (A-1) system ends up in an unexcited state. For a low initial nucleon momentum, corresponding to a nucleon in one of the orbitals, it is reasonable to expect that one can knock a nucleon out of one of the shells and have an (A-1) residual nucleus that


to and strike another nucleon. Of course, this will not be true if the struck nucleon is right next to another nucleon, and we will see that this is an issue when dealing with short range correlations. Again, the fact that short range correlations generate the high momentum nucleons will be an issue in using $y$-scaling to measure the nucleon momentum distribution.

So there are three things that are required for these $y$-scaling measurements to provide information on the nucleon momentum distribution: (1) quasielastic scattering must dominate, (2) final state interactions must be small, and (3) the spectator picture with an unexcited (A-1) residual state must be valid. By making measurements at large momentum transfer (to reduce FSI), and small energy transfer (to suppress inelastic excitations), we come close.consistent with the fact that the heavier nuclei have a larger Fermi motion, nor with the picture of two-nucleon interactions – which should occur in heavy nuclei as well as deuterium – generate the large momentum distributions. In addition, the peak is clearly asymmetric about $y=0$, although the uncertainty in the subtraction of the inelastic background is a significant concern for large $Q^2$ values. Finally, as mentioned in a previous section, the scaling function extracted should be consistent with the fact that it is related to a momentum distribution which has a known normalization[@mckeown86]. While this is satisfied for deuterium, the scaling function falls short of the normalization condition by more than 20% for heavy nuclei. One possibility is that final state interactions are larger than expected. However,


and without SRCs included in the model of the nuclear structure, to see the importance of the correlations. Figure \[fig:sargsian\], shows the cross section for inclusive scattering from Iron at $x=1$ and $x=1.5$[@arrington99], with calculations from[@sargsian03]. It is clear that for large $x$, one is dominated by scattering from the two-nucleon SRCs. There is also little indication for multi-nucleon SRCs in this data, at least at the level predicted by this particular model of 3N and 4N SRCs[@frankfurt80]. However, as the figure shows, the sensitivity becomes much larger at higher energy. As with the y-scaling analysis, this relies on a comparison of the data to a calculation of the cross section, but this direct comparison allows a much more realistic calculation than the PWIA model (and assumptions about theand featuring effects by the experienced stop-motion animator David W. Allen, the film is set in a mostly abandoned hotel and pits a gathering of psychics against a group of killer puppets. The film has long stretches of tedium, but its inspired moments make it hard to forget, and if you were a curious horror fan browsing a video store and hoping to find a film featuring puppets capable of drilling through human flesh or vomiting leeches, this was the jackpot.

Other series followed. Reuniting with Thomerson and — for a couple of pre–Mad About You entries — Hunt, Band revived the Trancers series for five sequels (to date). From Full Moon’s new outpost in Romania, Ted Nicolaou kicked off the hard-edged vampire series Subspecies, which produced five entries


tough for many years.”

There are always new movies to be made, and Band promises, “stand-alone, not humorous type” films. “It’s not like this is going to be a steady diet of Evil Bong movies.” And even if the days when adventurous video store patrons could walk out of a store with a stack of Full Moon titles are long gone, Band remains committed to his vision.

“The streaming sites are now slowly, hopefully bringing people back and they’re rediscovering what they like,” he says. “We have a pretty good share of young kids, too, who discover one or two [movies] and hopefully it’s like the old spread of it.”

Then he pauses.

“I don’t know. It’s always an adventure.”

Keith Phipps is a writer and editor specializing in film and TV. Formerly:Sexual differentiation of rat hepatic bile salt sulfotransferase isoenzymes.
The mature female rat has three times the hepatic bile salt sulfotransferase (BSS) activity compared with male rats. This study examined the changes in two hepatic BSS isoenzyme activities during sexual maturation, and the role of estrogen in development of sex differences in BSS activities in mature rats. DEAE-Sephadex A-50 chromatography of hepatic cytosol from prepubescent pups revealed that more than 90% of total BSS activity was due to BSS I activity relative to BSS II, similar to postpubertal females. Sex differences in total BSS activities and the isoenzyme patterns developed after the onset of puberty at 30-35 days of age. BSS I was still the predominant isoenzyme in the adolescent female, similar to the prepubescent pup and mature female.


In contrast, BSS I activity declined in adolescent males, which appeared to explain the fall in total BSS activity to only one-third of that of the female by maturity. BSS II activity was similar in both sexes at any age. Estrogen treatment of postpubertal male rats rapidly increased hepatic BSS capacity by enhancing BSS I activity producing an isoenzyme pattern similar to the mature female. This rapid enhancement of BSS I by estrogen was blocked by actinomycin D and puromycin. We concluded that 1) sex differences in BSS activities that develop during adolescence were in part due estrogen-maintaining BSS I activity in females and 2) estrogen regulates the synthesis of BSS I at a translational (or pretranslational) level.Aborigines did not know about vitamin B1, beriberi or that intense heat destroys enzymes; they just learned from their parents the correct way to prepare these foods as children – no doubt knowledge that was acquired through the trial and error of deceased ancestors. Their cultural learning had provided them with critical knowledge that Burke and Wills lacked. As the two explorers’ fates show, our intelligence and capacity for survival depends on what we learn from others.

Bruce Hood, The Domesticated Brain. 2014.

Food processing is one of the easiest parts of transmissible, reproducing culture for us to observe. The nixtamalization process, an ancient American method of processing corn, increases the availability of another B vitamin (niacin). Like the shellfish and nardoo of the Outback, corn without its associated cultural


lapply(1:3, FUN = function(ii) {
        label <- dfNames[ii]
        df <- dfList[[ii]]
        dt <- data.table(df, key=c("site", "run", "id"))
        groups <- unique(dt[,key(dt), with=FALSE])
        groups[, stream := seq_len(nrow(groups))]
        dt <- dt[groups]
        # Note: The following line only keeps the first 3 (rather than 20) rows
        dt <- dt[, head(cbind(.SD, i=seq_len(.N)), 3), by=stream]
        dt <- cbind(label, dt[,c("stream", "dir", "i", "payload")])
        df <-Maintaining rats for 5 days on a diet containing 60% casein augmented the relative amount of carbamyl phosphate synthetase mRNA by about 2-fold, while a protein-free diet resulted in reduced levels of the mRNA (about 50% compared to animals on a normal diet). Finally, the pattern of hybridization of carbamyl phosphate synthetase cDNA to HindIII-digested genomic DNA showed no differences between normal liver and its corresponding hepatoma; however, a HindIII site polymorphism was observed between Buffalo and ACI rats.


the sensitive A549 cells as well as 0.171 and 0.178 for the resistant A(549)/DDP cells respectively, but there is no significant difference of the polarization of 12-AS between the two cell lines. This shows that alterations of the membrane fluidity of both cells were mainly located on the surface and middle of the lipid bilayer. In addition, the packing density of phospholipid molecules in the membrane of the two cell lines detected by MC540 probe indicated that lipid packing of A(549) cell membranes was looser than that of the A(549)/DDP cells. And unsaturation degree of plasma membrane fatty acids of the A(549)/DDP cells was also lower than that of A(549) cells. Taken together, it was proposed that the alteration of membrane lipid biophysical state may be involved inThe World Is Not Enough – was almost inevitable. An unnamed source is quoted in the Mail as saying Purvis and Wade’s outline had been accepted before Boyle and Hodge came into the picture; they have now been given the go-ahead to complete a full script.

It is not clear what the “creative differences” were that led Boyle to leave Bond 25. Actor Jonathan Pryce suggested that producers “couldn’t take a socialist Bond”; another possibility is that Boyle had his choice of actors – principally Tomasz Kot as the lead villain – vetoed by executives.

However, the latter scenario has been thrown into doubt by a claim by Kite Runner and Wonder Woman star Said Taghmaoui that he had been cast in the main villain role. He told the Abu


Arizona Rattlesnakes

Identification

Rattlesnakes are usually identified by their warning rattle — a hiss or buzz — made by the rattles at the tip of their tails. A rattlesnake is born with a button, or rattler, and acquires a new rattle section each time it molts. Rattlesnakes also are distinguished by having rather flattened, triangular heads. The heads of all Crotalus rattlesnakes are about twice as wide as their necks.

Rattlesnakes belong to the pit viper family Crotalidae, so named because all possess visible loreal pits, or lateral heat sensory organs, between eye and nostril on each side of the head. These heat sensory pits are not present in true vipers, which do not occur in the Western Hemisphere. The facial pits enable rattlesnakes to seek out and strike, even into other teeth marks (all snakes have teeth; only pit vipers have fangs too). Rattlesnakes often bite livestock on the nose or head as the animals attempt to investigate them. Sheep, in particular, may crowd together in shaded areas near water during midday. As a consequence, they also frequently are bitten on the legs or lower body when pushed close to snakes. Fang marks and tissue discoloration that follows in the major blood vessels from the bite area are usually apparent on livestock that are bitten.

Snake Bites
The best protection for humans when traveling in snake country is common sense in choosing protective foot and leg wear. When climbing, one should beware of putting a hand up over rocks. Rattlesnakes might be waiting there for a rodent, and the


rotor. The forward movement of the aircraft comes in response to a thrusting engine such as a motor driven propeller mounted fore or aft.
During the developing years of aviation aircraft, autogyro aircraft were proposed to avoid the problem of aircraft stalling in flight and to reduce the need for runways. The relative airspeed of the rotating wing is independent of the forward airspeed of the autogyro, allowing slow ground speed for takeoff and landing, and safety in slow-speed flight. Engines may be tractor-mounted on the front of an autogyro or pusher-mounted on the rear of the autogyro.
Airflow passing the rotary wing, alternately called rotor blades, which are tilted upward toward the front of the autogyro, act somewhat like a windmill to provide the driving force to rotate theDRAM to XMP.

2. Set the CPU to 4.0 GHz (40x multiplier) with CPU Core Voltage to Manual and 1.000 volts.

3. Save and Exit, see if system boots to OS.

4. If entering OS fails, go back to BIOS and adjust voltage by +0.025 volts and return to step 3.

5. When in the OS, run the POV-Ray multithreaded benchmark and OCCT test for five minutes. If either tests fail, go back to BIOS and adjust voltage by +0.025 volts and return to step 3.

6. Monitor temperatures during OCCT test. If the temperature is at the top of the users limit, stop overclocking.

7. If temperatures are low, and both tests complete, then this CPU frequency/Core Voltage combination is stable and noted. To continue overclocking, go back to BIOS and adjust CPU


NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE
 * OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.
 *
 * ====================================================================
 *
 */

/*
 * linklist.c -- generic module for efficient memory management of
 * linked list elements of various sizes; a separate list for each
 * size.  Elements must be a multiple of a pointer size.
 *
 * HISTORY
 *
 * $Log$
 * Revision 1.10  2005/07/02  12:55:40  egouvea
 * Changed void* with char* to fix compilation problem when compiling with gcc4.0
 *
 * Revision 1.9  2004/12/10 16:48:56  rkm
 * Added continuous density acoustic model handling
 *
 * Revision 1.8  2004/05/18 19:02:40  egouvea
 * Removed line including malloc.h, already1. Field of the Invention
This invention relates to electric machines working as motors or generators. The invention is particularly applicable to reluctance motors.
2. Background Art
FIG. 1 of the drawings illustrates a known construction of single-phase salient pole switched reluctance machine which can be operated as either an electric motor or generator. However, for the sake of convenience the term motor will be used throughout this specification though it is to be understood that the invention is equally applicable to electric generators.
The switched reluctance motor of FIG. 1 comprises a stator core 1 and a rotor 2 which are both formed with four salient poles 3 and 4, respectively. The stator core is made up of numerous metal lateral laminations in a stack. Each salient stator pole 3 carries


honestly is absolutely liberating; I am personally and professionally enriched. Talk to Steve at CoachStation, it will probably be the best conversation you ever have.

Mackenzie Muir, IT Manager

CoachStation exists to improve our world, one leader at a time!

You will never compromise on doing what’s right and I will never hear you utter the words, ‘Because everyone else does it!’

CoachStation exists to improve our world, one leader at a time!

Steve was very supportive and considered…even if he knew that I might find some of his views challenging. I respected his integrity/honesty in approach.
Steve held me accountable to myself and to my responsibilities in my role.

Sales Manager, Financial Services

CoachStation exists to improve our world, one leader at a time!

Steve leaves behind a high performing contact centre, scarcely recognisable from theleader at a time!

Steve from CoachStation has had a significant positive impact on my professional life. I have been lucky enough to have accessed many professional development opportunities throughout my career, however can honestly say that the time I spend with Steve has been the most beneficial and rewarding.

Aimee Michell, Manager

CoachStation exists to improve our world, one leader at a time!

Steve is a strongly principled individual who has led by example. He has established strong relationships, both internally and externally and was asked to wear many hats: leader, consultant, contact centre manager and trainer. He has handled all these roles with great professionalism.

Gary Leonard, General Manager, Toyota Finance

CoachStation exists to improve our world, one leader at a time!

Steve from CoachStation has had a profound impact on my business


Takkarist McKinley was raised by his grandmother, and he promised just before she died that he’d make it to a Division I football team. Having achieved that—and then some—the UCLA defensive end brought a photo of his grandmother to the stage after his selection by the Falcons with the 26th pick; he then launched into a very emotional—and slightly profane—pronouncement. It earned a tsk-tsk from Deion Sanders.

[NFL Network]The new, sizeable chasm is not quite as big as the Grand Canyon, admittedly. Erik Harrison/Shutterstock

A gigantic crack has appeared in the foothills of the Bighorn Mountains in northern Wyoming. This crack isn’t just a few meters wide, mind you: it has opened up a gap 685 meters (2,250 feet) long and 45 meters (150 feet) wide. The locals are somewhat unfortunately nicknaming it the “gash”, as reported by the Huffington Post.

Sudden tectonic movements in Earth’s crust causes earthquakes, which displace large amounts of material in very short periods of time, often producing large fractures at the surface level. Mysteriously, no seismic activity of any kind was reported in the area, meaning that this miniature canyon was formed through other means.

While hunting this past weekend in the Bighorns,


it “the gash”. It’s a really incredible sight.Huntwyo.com Posted by SNS Outfitter & Guides on Friday, October 23, 2015

SNS captured an image of Wyoming’s mysterious new cavity.

This sudden major fracture would not normally be cause for concern, but this mountain range happens to be located fairly close to the Yellowstone caldera, a dormant supervolcano that has recently shown signs of its magma chamber being recharged. However, rising magma would cause seismic activity as it forces its way up through the crust, something which as mentioned was undetected at the time of the formation of the crevasse.

Nevertheless, social media will no doubt make the unfounded connection anyway.people they
like to blatantly violate the rules (without actually algorithmically demoting
the tweets, people will ignore the notice) or effectively shadowban people
they don't like without explaining why a tweet doesn't follow the ToS until
the subject matter is out of the news cycle.

~~~
TheHypnotist
On the other hand:

If your political stance violates the TOS that is enforced on non-public
offical users, is it really "political bias"? Maybe you should rethink your
politics if bullying, inciting violence, and inciting hate speech is part of
your position.

~~~
mfatica
I've seen far more on the left calling for bullying, inciting violence, and
inciting hate than the right.

~~~
taborj
Oh good, I'm not alone in seeing this trend. The left seems to have a more "if
you're not with us you're against us" stance.

------
DSingularity
Critical. I applaud them taking leadership here. I feel like the climate


>Notifications tab >Explore

Getting out in front of the 2020 election, I see. Better conform to Twitter's
code of conduct if you want to maximize reach!

Edit: Good time to get to know who will be making the decisions on throttling
exposure- do not cross these groups!
[https://about.twitter.com/en_us/safety/safety-
partners.html](https://about.twitter.com/en_us/safety/safety-partners.html)

~~~
simion314
Do you have a better solution? I am honestly thinking on how would I solve the
problem where I own a popular social network or forum/subreddit, I want to
prevent it to become a shit place, so I would like to put some rules like HN
and other communities have , how can I prevent the situation where people will
call me as censoring them on my own community? My only solution would be to
ban political discussion completely and implement some hard punishment for
people that don't respect the community rulesthis alloy was assessed to be one of the reasons of its limited properties. In 1982, E. A. Starke stated (in Metallurgical Transactions A, Vol 13A, p 2267) “The larger Mn-rich dispersoids may also be detrimental to ductility by initiating voids”. This idea of a detrimental effect of Mn was broadly recognized by those skilled in the art. For example, in 1991, Blackenship stated (in Proceedings of the Sixth International Aluminum-Lithium Conference, Garmisch-Partenkirchen, p 190), “Manganese-rich dispersoids nucleate voids and thus encourage the fracture process”. It was suggested that zirconium should be used instead of manganese for grain structure control. In the same document, Blackenship stated, “zirconium is the alloying element of choice for grain structure control in Al—Li—X”.
The development of AlLi alloys continued in the 1980s and


(return to play rate of 80%). In comparing preinjury with postinjury statistics, players exhibited a significant decrease in plate appearances, at-bats, and WAR 2 seasons after injury but did not demonstrate declines in WAR 1 season after injury. Compared with matched controls, athletes who underwent MUCL reconstruction did not demonstrate significant decline in statistical performance, including OPS, WAR, and ISO, after return to play from surgery. Of all positional players, catchers undergoing surgery demonstrated lowest rates of return to play (56%) along with statistically significant decreases in home run rate, runs batted in, and ISO. Major League Baseball positional players undergoing MUCL reconstruction can reasonably expect to return to their preinjury level of competition and performance after surgery compared with their peers. Positional players return to play atoffspring^[@CR24]^. In another study, Boucher et al. have found that polychlorinated biphenyls (PCB) interfere with the normal functioning of vital metabolic pathways in the liver and are associated with the development of NAFLD^[@CR25]^. In addition, in our previous study, histopathological study in the liver revealed steatosis with hepatocellular ballooning degeneration in rats exposed to HSHFD plus NP^[@CR26]^. Nonetheless, the effect of NP on the promotion of NAFLD development has not been demonstrated yet. Therefore, the present study was designed to test the hypothesis that subchronic NP exposure causes a predisposition to NAFLD. Specifically, we tested whether a combination of NP and high-sucrose/high-fat diet interacts in an additive or an antagonistic way.

Materials and Methods {#Sec2}
=====================

Ethics Statement {#Sec3}
----------------

Animal experimental procedures were approved by Zunyi Medical University Ethics Committee. All methods


NetBios または FQDN の形式で入力できます (FABRIKAM\administrator または fabrikam.com\administrator)。 |
| 既存のアカウントを使用します | ディレクトリ同期中に Azure AD Connect が Azure AD Connect に接続する際に使用される既存の AD DS アカウントを指定する場合は、このオプションを選択します。 ドメインの部分は NetBios または FQDN の形式で入力できます (FABRIKAM\syncuser または fabrikam.com\syncuser)。 このアカウントには既定の読み取りアクセス許可が必要なだけなので、通常のユーザー アカウントを指定できます。 ただし、シナリオによっては、アクセス許可がさらに必要になることがあります。 詳細については、[Azure AD Connect アカウントとアクセス許可](reference-connect-accounts-permissions.md#create-the-ad-ds-connector-account)に関するページを参照してください。 |

![ディレクトリの接続](./media/how-to-connect-install-custom/connectdir02.png)

#### エンタープライズ管理者アカウントとドメイン管理者アカウントはサポートされない
ビルド 1.4.18.0 以降では、エンタープライズ管理者アカウントまたはドメイン管理者アカウントを AD DS コネクタ アカウントとして使用することはサポートされません。  **既存のアカウントを使用**するよう指定するときにエンタープライズ管理者アカウントまたはドメイン管理者アカウントを入力しようとすると、次のエラーが発生します。

  **"AD フォレスト アカウントにエンタープライズまたはドメインの管理者アカウントを使用することはできません。Azure AD Connect でアカウントを作成するか、適切なアクセス許可を持つ同期アカウントを指定してください。<詳細情報>"**

### Azure AD サインインの構成
このページでは、オンプレミスの AD DS に存在し、Azure AD で検証された UPN ドメインを確認できます。 また、userPrincipalName に使用する属性を構成できます。

![Unverified domains](./media/how-to-connect-install-custom/aadsigninconfig2.png)
**[Not Added (追加されていません)]** と **[Not Verified (検証されていません)]** のマークが付いたドメインをすべて確認します。 使用するドメインを Azure AD で検証済みにしてください。 対象のドメインを検証済みにしたら、更新シンボルをクリックします。 詳細については、[ドメインの追加と検証](../fundamentals/add-custom-domain.md)に関するページを参照してください。

**UserPrincipalName** - userPrincipalName 属性は、ユーザーが Azure AD と Office 365 にサインインするときに使用する属性です。 使用するドメイン (UPN サフィックス) は、ユーザーを同期する前に、Azure AD で検証する必要があります。 既定の userPrincipalName 属性のままにしておくことをお勧めします。 この属性がルーティング不可能で検証できない場合は、別の属性を選択することができます。 たとえば、サインイン ID を保持する属性として電子メールを選択することができます。 userPrincipalName 以外の属性を使用する方法は、 **代替 ID**と呼ばれます。 代替 ID の属性値は、RFC822 標準に従う必要があります。 代替 ID は、パスワード ハッシュの同期、パススルー認証、およびフェデレーションで使用できます。 Active Directory では、値が 1 つのみであってもこの属性を複数値として定義できません。 代替 ID の詳細については、[よく寄せられる質問](./how-to-connect-pta-faq.md#does-pass-through-authentication-support-alternate-id-as-the-username-instead-of-userprincipalname)のトピックを参照してください。

>[!NOTE]
> パススルー認証を有効にする場合、ウィザードを続行するために少なくとも 1|
| sAMAccountName および MailNickName |このオプションは、ユーザーのサインイン ID を見つけるために必要な属性同士を結合します。 |
| 特有の属性 |このオプションでは、独自の属性を選択することができます。 このオプションを選択した場合、(選択した) 属性が設定されていないユーザー オブジェクトは、Azure AD との間で同期されません。 **制限:** このオプションでは、既にメタバースで検出できる属性のみを使用できます。 |

#### Azure AD でのユーザーの識別方法を選択する - ソース アンカー
sourceAnchor 属性は、ユーザー オブジェクトの有効期間中に変更できない属性です。 オンプレミスのユーザーと Azure AD のユーザーをリンクするプライマリ キーです。

| 設定 | 説明 |
| --- | --- |
| ソース アンカーの管理を Azure に任せる | Azure AD に属性を選択させる場合は、このオプションを選択します。 このオプションを選択すると、Azure AD Connect ウィザードが sourceAnchor 属性選択ロジックを適用します。このロジックについては、「[Azure AD Connect: 設計概念」の「sourceAnchor としての ms-DS-ConsistencyGuid の使用](plan-connect-design-concepts.md#using-ms-ds-consistencyguid-as-sourceanchor)」を参照してください。 どの属性がソース アンカー属性として選択されたかは、カスタム インストールの完了後、ウィザードに表示されます。 |
| 特有の属性 | sourceAnchor 属性として既存の AD 属性を指定する場合は、このオプションを選択します。 |

この属性は変更できないため、適切な属性を使用するように計画する必要があります。 適切な属性として考えられるのは objectGUID です。 この属性は、ユーザー アカウントをフォレスト/ドメイン間で移動しなければ、変更されません。 ユーザーが結婚したり割り当てが変更されたりした場合に変化する可能性のある属性は、使用しないようにしてください。 @-sign が含まれる属性は使用できないので、電子メールや userPrincipalName は使用できません。 属性では大文字と小文字も区別されるため、フォレスト間でオブジェクトを移動する場合は、大文字と小文字をそのままの状態に維持するようにしてください。 バイナリ属性は base64 でエンコードされますが、他の種類の属性はエンコードされない状態のままになります。 フェデレーション シナリオと一部の Azure AD インターフェイスでは、この属性は immutableID とも呼ばれます。 ソース アンカーの詳細については、[設計概念](plan-connect-design-concepts.md#sourceanchor)に関するページを参照してください。

### グループに基づく同期フィルタリング
グループに基づくフィルタリング機能では、パイロット用にごく一部のオブジェクトのみを同期することができます。 この機能を使用するには、対象とするグループをオンプレミスの Active Directory に作成します。 次に、直接のメンバーとして Azure AD に同期するユーザーとグループを追加します。 このグループには後でユーザーを追加したりユーザーを削除したりして、Azure AD に表示するオブジェクトの一覧を管理することができます。 同期するオブジェクトはすべて、グループの直接のメンバーである必要があります。 ユーザー、グループ、連絡先、およびコンピューター/デバイスは、すべて直接のメンバーにする必要があります。 入れ子になったグループのメンバーシップは解決されません。 グループをメンバーとして追加すると、グループ自体は追加されますが、そのグループのメンバーは追加されません。

![フィルターの同期](./media/how-to-connect-install-custom/filter2.png)

> [!WARNING]
> この機能は、パイロット デプロイのサポートのみを目的としています。 本格的な運用環境のデプロイでは使用しないでください。
>
>

本格的な運用環境のデプロイでは、単一のグループを維持しながらすべてのオブジェクトを同期することは困難になります。 代わりに、[フィルター処理の構成](how-to-connect-sync-configure-filtering.md)に関するページで説明されている手法のいずれかを使用してください。

### オプション機能
この画面では、特定のシナリオのためにオプション機能を選択することができます。

>[!WARNING]
>**1.0.8641.0** とそれ以前のバージョンの Azure AD Connect では、パスワード ライトバックで Azure Access Control サービスに依存しています。


cannot be overwritten (ADSync データベースに既にデータが含まれており、上書きできません)"
Azure AD Connect をカスタム インストールし、 **[必須コンポーネントのインストール]** ページで **[既存の SQL サーバーを使用する]** オプションを選択すると、 **"The ADSync database already contains data and cannot be overwritten. (ADSync データベースに既にデータが含まれており、上書きできません。) Please remove the existing database and try again. (既存のデータベースを削除してからやり直してください。)"** と表示されるエラーが発生することがあります。

![エラー](./media/how-to-connect-install-custom/error1.png)

これは、上のテキスト ボックスで指定した SQL サーバーの SQL インスタンスに、**ADSync** という名前のデータベースが既に存在するためです。

これは通常、Azure AD Connect をアンインストールした後で発生します。  アンインストールしても、データベースは SQL Server から削除されません。

この問題を解決するには、まず、アンインストール前に Azure AD Connect によって使用されていた **ADSync** データベースが既に使用されていないことを確認します。

削除する前に、データベースをバックアップすることをお勧めします。

データベースは手作業で削除する必要があります。  そのためには、**Microsoft SQL Server Management Studio** を使用して、SQL インスタンスに接続します。 **ADSync** データベースを探して右クリックし、コンテキスト メニューの **[削除]** を選択します。  **[OK]** をクリックして削除します。

![エラー](./media/how-to-connect-install-custom/error2.png)

**ADSync** データベースの削除後、**インストール** ボタンをクリックして、インストールを再試行します。

## 次のステップ
インストールが完了した後、 Synchronization Service Manager または同期規則エディターを使用する前に、サインアウトし、もう一度 Windows にサインインします。

Azure AD Connect がインストールされたので、[インストールを確認し、ライセンスを割り当てる](how-to-connect-post-installation.md)ことができます。

インストールの結果有効になった機能について詳しくは、[誤った削除操作を防止する機能](how-to-connect-sync-feature-prevent-accidental-deletes.md)と [Azure AD Connect Health](how-to-connect-health-sync.md) に関する各ページを参照してください。

一般的なトピックについては、[スケジューラの使用と同期のトリガー方法](how-to-connect-sync-feature-scheduler.md)に関するページを参照してください。

「 [オンプレミス ID と Azure Active Directory の統合](whatis-hybrid-identity.md)」をご覧ください。complaint, telling him his only remedy was filing a civil lawsuit. After the City spent years in court defending the officers' arrest of Glik as constitutional and reasonable, IAD reversed course after the First Circuit ruling and disciplined two of the officers for using "unreasonable judgment" in arresting Glik.

Fluffeh writes: "Australia’s competition regulator will today take iconic technology giant Apple to court for advertising its new iPad tablet as featuring “4G” speeds — which are not supported on Australian telecommunications networks. One of the key features of the new iPad is support for 4G speeds, however, the 4G speeds which the new iPad supports will not be available in Australia, with Apple’s technical specifications page only listing it as supporting the 700Mhz and 2100Mhz spectrum bands, neither of


158 So.2d 228 (1963)
Oliver C. TAPP, Plaintiff-Appellant,
v.
GUARANTY FINANCE COMPANY, Inc., and Elmer A. Uffman, Defendants-Appellees.
No. 5963.
Court of Appeal of Louisiana, First Circuit.
November 12, 1963.
Rehearing Denied December 16, 1963.
Writ Refused February 14, 1964.
*229 Ralph Brewer, Baton Rouge, for appellant.
Kennon, White & Odom, by John S. White, Jr., Watson, Blanche, Wilson, Posner & Thibaut, by Charles W. Wilson, Baton Rouge, for appellees.
Before ELLIS, LOTTINGER, HERGET, LANDRY and REID, JJ.
ELLIS, Judge.
Plaintiff, Oliver C. Tapp, purchased an automobile on August 11, 1956 from Leland Mims Used Cars, represented by Leland G. Mims. The unpaid portion of the purchase price was represented by a promissory installment note payable to Leland Mims Used Cars and paraphed for identification with a chattel mortgage on the automobile. The note is endorsed by "Leland Mims Used Cars,been garnished and seized and there is no testimony whatsoever that he was damaged for any continued illegal seizure of these wages, and of course, he did not lose the wages as they would not have been paid to him in any event but would have been applied on his indebtedness, as was done when the garnishment was released.
As to items (2) and (5) plaintiff testified that as a result of the garnishment he was embarrassed, had a fear of "losing everything that I owned, my new home that I just bought, my wife was deprived of medicine that she should have had and because she had been operated on we didn't have money to spend for it * * *".
In Scott v. Columbia Finance Corporation, La.App., 119


Prostaglandin fever in rats throughout the estrous cycle late pregnancy and post parturition.
We have examined the influence of natural variations in endocrine status on the ability to generate a prostaglandin-induced fever in virgin female, pregnant and lactating rats and compared responses to those in male rats. Endocrine status of virgin female rats was assessed from examination of vaginal smears and time of parturition noted to enable accurate dating of pre- and postparturient fevers. Unanesthetized rats, previously prepared with intraventricular guide cannulas and intraperitoneal telemetry thermistors, were given intraventricular injections of prostaglandin E1 (2-100 ng/5 microliters) and temperatures monitored for 3 h after injection. Virgin females developed significantly larger fevers than did males at higher doses. There were no significant alterations in either fever height or duration as aPoints

Denise Peck

The length and the sophisticated wire wrapping of these earrings make them an elegant addition to your jewelry box. Embellish them with any beads you like for a personal touch.

* * *

Techniques Used

hammering

piercing

coiling

wrapped loops

opening and closing jump rings

* * *

### Materials

3" (7.5 cm) of sterling silver 18-gauge dead-soft round wire

10" (25.5 cm) of sterling silver 20-gauge dead-soft round or twisted wire

2 sterling silver head pins

2 decorative beads

2 sterling silver ear wires

### Tools

Flush cutters

Chain-nose pliers

Awl

Ball-peen hammer

Steel bench block

### Finished Size

2½" (6.5 cm) silver pair,

2⅜" (6 cm) blue pair

**1.** Cut the 18g wire into two 1½" (3.8 cm) lengths. Hammer flat all ends.

**2.** With the awl, make a hole on each flattened end to accommodate 20g wire.

**3.** Coil the 20g wire tightly and closely around one 18g wire so


other cells to regenerate and repair damaged tissue.

The division is based on the patented ADAPT® Tissue Engineering Process as a platform technology to produce implantable tissue patches for use in various soft tissue repair applications and for the production of replacement tissue heart valves. The ADAPT® technology is used to process animal derived tissues to produce unique implantable tissue patches that are compatible with the human body. The technology has a number of advantages over current tissue treatment processes on the market, most notably the reduction of calcification post implantation. This technology has the potential for medical professionals to use regenerative products instead of synthetic products currently used in soft tissue repair.vol 3: Quantum Mechanics, Non-relativistic Theory*, Oxford, Pergamon Press (1958).

N. Levinson, *On the uniqueness of the potential in a Schrödinger equation for a given asymptotic phase*, Danske Vid. Selsk. Mat.-Fys. Medd. [[25]{}]{} (1949), no. 9, 29.

B. Levitan and I. Sargsjan, *Introduction to Spectral Theory: Self-adjoint Ordinary Differential Operators*, United States of America, American Mathematical Society (1975).

M. Lukic, *A class of Schrödinger operators with decaying oscillatory potentials*, Comm. Math. Phys. [326]{} (2014), no. 2, 441–458.

M. Lukic, *Schrödinger operators with slowly decaying Wigner-von Neumann type potentials*, J. Spectr. Theory [3]{} (2013), no. 2, 147–169. M. Lukic and D.C. Ong, *Wigner-von Neumann type perturbations of periodic Schrödinger operators*, Trans. Amer. Math. Soc. [[[367]{}]{}]{} (2014), no. 1, 707–724.

M. Moszynski, *Slowly oscillating perturbations of periodic Jacobi operators in $l^2(\mathbb{N})$*, Studia Math. 192 (2009),


its tyrosine kinase B (TrkB) receptor, plays an important role in neuroplasticity. BDNF has also been shown to be expressed at high levels in the hippocampus and to play an important role in synaptic transmission and in the plasticity of the hippocampus \[[@b23-medscimonit-19-438],[@b24-medscimonit-19-438]\]. BDNF also mediates some of the injurious effects of glucocorticoids on the hippocampus \[[@b25-medscimonit-19-438],[@b26-medscimonit-19-438]\]. BDNF expression is regulated by stress-responsive corticosteroids, and increased glucocorticoid exposure induces a reduction in BDNF level \[[@b27-medscimonit-19-438]\]. Chronic stress has been shown to result in alterations in BDNF/TrkB signaling and changes in neuronal functions \[[@b28-medscimonit-19-438]\]. Serotonergic axon sprouting appears to be dependent on BDNF, which appears to be decreased after stress exposure. Thus, stress and depression may increase neuronal atrophy degeneration. Furthermore, hippocampal neurons continue to proliferate well into adulthood.suggested that miR-132 plays an important role in the etiology of depression.

MiR-132 has Functions in the Cardiovascular System
==================================================

There is scant literature on the function of miR-132 in the cardiovascular system. However, the existing literature suggests that miR-132 has functions in the cardiovascular system.

The cardiovascular system is controlled by the nervous system, mainly by the autonomic nervous system; therefore, BDNF can influence the cardiovascular system via the autonomic nervous system. BDNF is important for autonomic nervous system function. BDNF is known to play an important role in regulating the survival of neurons in the autonomic nervous system and the formation of their synaptic connectivity with their peripheral targets in the cardiovascular, digestive, and other organ systems. Emerging evidence suggests that BDNF may also affect the function of the autonomic


in quantum annealing [@Marvian17; @Jiang17]. Nonstoquasticity may also be achieved via nonadiabatic evolution [@Vinci].

Hamiltonian
===========

To implement a nonstoquastic Hamiltonian, we use two rf-SQUIDs coupled both inductively, through a tunable mutual inductance $M_{12}$ [@Harris09], and capacitively, through a fixed capacitance $C_{12}$ as shown in Fig. \[fig:schematics\][(a)]{}. The Hamiltonian of the system is $$\begin{aligned}
H &=&  \sum_{i=1}^2 \left[ \frac{Q_i^2}{ 2 \widetilde C_i} {+}
\frac{(\Phi_{\text{q},i} {-} \Phi_{\text{q},i}^x)^2}{2 L_i} {-} E_{Ji} (\Phi_{{\rm
cjj},i}^x)  \cos  \frac{ 2 \pi \Phi_{\text{q},i}}{\Phi_0}  \right] \nonumber \\
&&+\frac{M_{12}(\Phi_{\rm co}^x) (\Phi_{\text{q},1} {-} \Phi_{\text{q},1}^x)(\Phi_{\text{q},2} {-} \Phi_{\text{q},2}^x) }{L_1
L_2} \nonumber \\
&& + \frac{C_{12} \, Q_1 Q_2}{C_1 C_2 {+} (C_1 {+} C_2) C_{12} },
\hspace{5mm} \label{HSQUIDs} \end{aligned}$$ where $ Q_i$ and $\Phi_{\text{q},i}$ are charge and flux variables that satisfy the commutation relation $[ \Phi_{\text{q},i}, Q_j] = i \hbar \,\delta_{ij}$, $\Phi_{\text{q},i}^x$ and $\Phi_{{\rm cjj},i}^x$ are external fluxes,quenched by rapidly raising their energy barriers via $\Phi^x_{\rm cjj,i}$, followed by qubit state readout. We repeat this process for a range of dwell times $\tau$ and coupling strengths $M_{12}$.

In Figs. \[fig:coherent-oscillation\][(a),(b)]{}, we show the measured state population $P_{\uparrow\downarrow}$ and $P_{\downarrow\downarrow}$ for qubits initially prepared in $\ket{\downarrow\uparrow}$ and $\ket{\uparrow\uparrow}$ configurations, respectively, for $h_i = 0$. The agreement between time domain experiments and numerical simulations, shown in Fig. \[fig:coherent-oscillation\][(d),(e)]{}, justifies the two-qubit Hamiltonian (\[H2state\]) as a valid description of the circuit in Fig. \[fig:schematics\](a). Deviation between theory and experiment can be attributed to decoherence, which is absent in simulations. Single qubit measurements reveal relaxation and dephasing times of $T_1=17$ ns and $T_2=16$ ns, respectively. These timescales are consistent with measurements of isolated flux qubits manufactured in the same stack but without the capacitive coupling.

Features


universal quantum annealers [@Aharonov; @Biamonte; @Jordan]. Our implementation is based on current, scalable superconducting fabrication technology that is ready to be expanded to a large number of qubits. Finally, we should mention that for large scale systems having $\sigma^y_i\sigma^y_j$ terms can make QMC simulation intractable even if the Hamiltonian is stoquastic. This is because finding a local transformation to cure sign problem at large scale is by itself intractable [@Lidar18].

Acknowledgements {#acknowledgements .unnumbered}
================

We are grateful to D. Lidar and M. Marvian for pointing out unitary transformations that cure sign problem at zero bias. We also thank J. Biamonte, D. DiVincenzo, I. Hen, J. Klassen, P. Love, J. Raymond, P. Saint-Jean, and B. Terhal for fruitful discussions, and F. Hanington and A. King for carefully reading the manuscript.

System Hamiltonian {#Hamiltonian}
==================

Our goal here is to derive a Hamiltonian of two rf-SQUIDs that havecjj}$ and define an effective potential of the main loop by finding the minimum potential energy of the system (\[Hs1\]) for each given flux $\Phi_{q}$: $$\label{Ueff1}
U_{\rm eff}(\Phi_{q}) = {\rm min}_{\Phi_{\rm cjj}} U(\Phi_{q}, \Phi_{\rm cjj}),$$ where $$\begin{aligned}
U(\Phi_{q}, \Phi_{\rm cjj}) = \sum_{\kappa=q,{\rm cjj}} \frac{(\Phi_\kappa - \Phi^x_\kappa)^2}{2 L_\kappa} - \nonumber \\E_J\, \cos \left( \frac{\pi \Phi_{\rm cjj}}{\Phi_0} \right)\, \cos \left( 2 \pi \frac{\Phi_q}{\Phi_0}\right). \end{aligned}$$ This leads to the following effective Hamiltonian for the rf-SQUID, $$H = \frac{Q_q^2}{2 C_q} + U_{\rm eff}(\Phi_{q}) .$$ As a rough approximation, the effective potential energy of the rf-SQUID can be written as $$\label{Ueff2}
U_{\rm eff}(\Phi_{q}) = \frac{(\Phi_q - \Phi^x_q)^2}{2 L_q} - E_J(\Phi_{\rm cjj}^x)\,  \cos \left( 2 \pi \frac{\Phi_q}{\Phi_0}\right),$$ with a tunable Josephson energy $$E_J(\Phi_{\rm cjj}^x) = \frac{\Phi_0 I_c}{2\pi} \, \cos \left(\pi \frac{\Phi^x_{\rm cjj}}{\Phi_0}\right).$$ However, in our


flux $\Phi_{q,i}.$ Charge $Q_i = \partial {\cal L}/\partial \dot \Phi_{q,i}$ of the $i-$qubit is defined as a derivative of the two-qubit Lagrangian $$\label{Lagr}
{\cal L} = K - \sum_{i=1}^2 U_{{\rm eff},i}(\Phi_{q,i}) - U_{12},$$ where $U_{{\rm eff},i}(\Phi_{q,i})$ is the effective potential energy of the $i-$qubit (see Eqs. (\[Ueff1\]) and (\[Ueff2\])). Using Eqs. (\[KinEn\], \[Lagr\]), we obtain the relation between charge and time derivatives of flux, $$\begin{aligned}
Q_1 = (C_1 + C_{12}) \dot\Phi_{q,1} - C_{12} \dot\Phi_{q,2}, \nonumber \\
Q_2 = (C_2 + C_{12}) \dot\Phi_{q,2} - C_{12} \dot\Phi_{q,1}.\end{aligned}$$ We can now write the total Hamiltonian of two coupled rf-SQUIDs, $H = \sum_i \dot\Phi_{q,i} Q_i - {\cal L}$, as $$\label{HamT}
H = \sum_{i=1}^2 H_i +  U_M  + U_C.$$ Here $$\label{HamI}
H_i = \frac{Q_i^2}{ 2 \tilde C_i} {+} U_{{\rm eff},i}(\Phi_{q,i})$$ is the Hamiltonian of $i$-qubit. The qubits arenonstoquastic depending on the magnitude of the coupling. The matrix (\[Hc3\]) also provides the intuition necessary to see effects of $J_{xx}$ and $h_1, h_2$ terms on experimentally measured spectra. When $J_{zz}=0$ and $h_1 = h_2=0$, the Hamiltonian is block-diagonal as there is no interaction between aligned and anti-aligned states. In the absence of the $J_{xx}$ term, the eigenvalues of the Hamiltonian becomes $ \pm \sqrt{J_{yy}^2 + \left(\frac{\Delta_1\pm\Delta_2}{2}\right)^2}$. Without the $J_{xx}$ term, the two highest eigenvalues can only cross if $\Delta_1 \Delta_2= 0.$ However we see a clear level crossing in spectroscopy vs. $\Phi_{\text{cjj},1}^x$ plots in the middle row of Fig. \[fig:2q-spectroscopy-extra\] where $\Delta_i \neq 0$. This is a clear signature of a $J_{xx}$ type interaction. Furthermore, the second and third excited states, that cross in presence of $J_{xx}$ belong to


3.157~\mu$A, $L_1 = 231.6~$pH, $L_2 = 239.0~$pH.

![Measured persistent current $I_p$ versus $\Phi_{{\rm cjj }}^x$ that controls the barrier height of the double-well potential and a fit to the classical model of Qubit 1.[]{data-label="fig:icirc-fit"}](icirc-fit){width="80mm"}

Single-qubit spectroscopy
-------------------------

![(a) Pulse sequence and the effective qubit potential at each pulse segment for the single-qubit spectroscopy experiments. (b) Color plot of the microwave spectroscopy data versus the flux bias $\Phi_\text{cjj}^x$ that controls the barrier height for Qubit 1. (c) Extracted spectroscopy peak positions that represent the qubit frequency versus $\Phi_\text{cjj}^x$ and a fit to the numerical rf-SQUID model.[]{data-label="fig:1q-spectroscopy"}](1q-spectroscopy-pulse){width="80mm"}

The qubit energy eigenstates can be characterized by performing microwave spectroscopy. In Fig. \[fig:1q-spectroscopy\][(a)]{}, we show the pulse sequence for measuring the qubit spectroscopy and the effective qubit potential at each segment of the pulse sequence. The qubit isbetween the numerical model and the data is achieved. In all figures the solid (dashed) lines represent excitations from the ground (first excited) state.

Pulse distortion compensation for coherent oscillations
=======================================================

Short duration pulse ($\le 10$ ns) distortion imposes a great limitation on the fidelity of coherent qubit operation. In our experiment, the qubit control involves applying fast pulses to lower and rise the tunneling barrier of the flux qubits. These pulses have short rise and fall times ($\approx 200$ ps). Here, we discuss our method of measuring and correcting pulse distortion in-situ.

![Characterization and compensation of pulse distortion. The coherent oscillation data, measured tunneling amplitude $\Delta_m$, and applied barrier pulses without (blue) and with (green) pulse distortion corrections.[]{data-label="fig:pulse-compen"}](pulse-correction){width="80mm"}

We first measure the single-qubit coherent oscillations at $\Delta/h = 5$ GHz, where the qubit population in


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Nissan and Playstation are partnering up to see if gaming really teaches a skill. Does playing Gran Turismo prepare you to be a real-world race car driver? 53,000 people competed in the online Round 1 tournament to find out if they had what it takes. Only 32 of themlocal levels \[[@pone.0220152.ref012]\]. However, evidence suggests that such collaborations are limited to outbreaks and are not sustained in endemic periods \[[@pone.0220152.ref013]\]. To establish a sustained, proactive and routine system, prioritization of zoonotic conditions through multi-sectoral collaboration within the respective settings is of utmost importance. Joint prioritization of zoonoses should benefit for the efficient and effective surveillance, developing laboratory capacity, targeting efficient outbreak prediction, implementing common disease control strategies, and identifying integrated research activities across sectors: human, animal, environmental \[[@pone.0220152.ref014]\].

Historically, infectious disease prioritization was within the purview of public health officials \[[@pone.0220152.ref015],[@pone.0220152.ref016]\]. However, with progress of public health strategies, prioritization became an important tool for various stakeholders to receive common funding or for implementing joint research projects. The approaches used to prioritize diseases are: qualitative, semi-quantitative or quantitative \[[@pone.0220152.ref017]--[@pone.0220152.ref019]\].

With


                      NA

(\*) A consistency ratio of \<0.1 is acceptable (Group 3 & 5 were excluded from the approximation for the final weights)

\(#\) Score gained during the Analytical Hierarchy process (Individual group rank)

With the help of a decision-tree analysis, the weight of each criterion was applied and a final weighted score was obtained to rank the diseases, which is shown in [Table 1](#pone.0220152.t001){ref-type="table"}. Based on discussion, the stakeholders reached a consensus that the top two diseases remain unchanged, however, there was a change in the priority of other prioritized diseases ([Table 3](#pone.0220152.t003){ref-type="table"}). This adjustment was done in view of the emerging cases in the city as well considering theweighted criteria (r = 0.86, p \<0.01). There was also a strong positive correlation when excluding each criterion, then comparing disease scores to those produced by the OHZDP tool (r = 0.89--0.99, p \<0.01).

![Comparison of normalized disease prioritization scores obtained from weighted criteria and with equal criteria weights, with reverse criteria weights and excluding each of the five criteria in the prioritization process in Ahmedabad, Western city of India during September 2018.\
(HD) Human disease, (EP) Epidemic potential, (PC) Prevention control, (AD) Animal disease, (IC) Intersectoral collaboration.](pone.0220152.g002){#pone.0220152.g002}

Discussion {#sec015}
==========

Participatory workshops for the prioritization of zoonotic diseases have been conducted in multiple countries, generating a unique list of priority zoonosis for each country. However, this is the first time such a workshop was conducted at a city level in India. The


the activity of the IVS1 allele. To test this, we used long-range allele-specific PCR and Sanger sequencing of a 4.4 kb region comprising exon 1--3. In a cohort of 143 compound heterozygous IVS1 patients that contained a deleterious variant on the second allele, we identified 21 SNVs ([Fig. 1](#f0005){ref-type="fig"}B). Interestingly, all but one were located on non-IVS1 alleles, except for the synonymous variant c.510C\>T, which was found in a subset of patients exclusively on the IVS1 allele. The c.510C\>T variant was found in 9 patients, all of whom had symptom onset in childhood (see Table S2 for patient details). While c.510C\>T occurred in combination with the IVS1 variant in 9/33 (27%) of the population of IVS1 patients with childhood onset, it occurred in 0/110 (0%) of patients with symptomfor the aberrant splice products SV2 and SV3. (F) Ratio of SV2/SV3. In healthy control cells, expression of SV2 and SV3 was too low to allow quantification. Data in d-e represent means ± SD (n= 3 biological replicates). \* = p \< 0.05, \*\*\* = p \< 0.001.Fig. 3

The enzymatic activity of GAA in compound heterozygous patients is derived from the IVS1 allele via leaky wild-type splicing, which produces 10--15% of normal mRNA transcript and full-length GAA protein. Homozygous IVS1 patients should have twice the amount of this activity, reaching 20--30%, which, using the assay conditions employed here, would be above the disease threshold. Consistent with this fact, only few homozygous IVS1 patients have been reported in the literature. In our cohort 10 unrelated individuals homozygous for IVS1


AONs directed at exon 2 sequences were also able to elevate normal splicing \[[@bb0180]\]. These findings highlight the importance of diagnostic screening and the potential for development of new treatment strategies for variants involved in splicing such as c.510C\>T \[[@bb0185]\].

Although few symptomatic homozygous IVS1 patients have been reported in the literature \[[@bb0055],[@bb0085],[@bb0095],[@bb0100]\], a large number of compound heterozygous IVS1 patients have been reported in Europe, with many more in countries in North and South America, Australia and New Zealand \[[@bb0010], [@bb0015], [@bb0020], [@bb0025], [@bb0030], [@bb0035], [@bb0040], [@bb0045], [@bb0050], [@bb0055], [@bb0060], [@bb0065],[@bb0115]\]. This suggests that many homozygous IVS1 patients remain asymptomatic, but that a subset develops symptoms \[[@bb0055],[@bb0095]\]. Due to NBS programs, the group of identified asymptomatic individuals who are homozygous for IVS1 is increasing, bringing challenges regarding theUltrasonography of symptomatic rotator cuff tears compared with MR imaging and surgery.
To compare the accuracy of ultrasonography and magnetic resonance imaging in the detection of rotator cuff tears. Ninety-six patients with clinically suspected rotator cuff pathology underwent ultrasonography and magnetic resonance imaging of the shoulder. The findings in 88 patients were compared with arthroscopy or open surgery. Full-thickness tear was confirmed in 57 cases, partial-thickness tear in 30 cases and degenerative changes without tear in 1. In all 57 cases of full-thickness tear and in 28 out of 30 cases of partial-thickness tear the supraspinatus tendon was involved. The accuracy in the detection of full-thickness tears was 98 and 100% for ultrasonography and magnetic resonance imaging, respectively. The accuracy in the detection of bursal or articular partial-thickness tears


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