this purpose the upper panel of Fig. \[fig:Mdot\_Jdot\_of\_t\]. There is a clear boundary at $r\approx 1.2-1.3 R_\ast$, which is approximately given by the location of the maximum of $\Omega$ and divides the rather organized, inward directed mass flux in the disk from the alternating transport in the BL, where mass is sloshing about back and forth in radius because of the passage of waves which have alternating signs of mass transport. This is clearly visible in the form of the diagonal features in the upper panel of Fig. \[fig:Mdot\_Jdot\_of\_t\]. Thus, the direction of the mass transport in the BL is both a function of time and radius, and the variability with time is on the order of one orbit. After roughly 600 orbits, the strength of the mass transport ceasesevolve, and 50 orbits later the system is recovering from the outburst. While the vorticity derivative of the quiet and post-outburst state does not change sign for $r>1.2 R_\ast$, it does change several times for orbit 150. The region $r>1.2 R_\ast$ is of interest here because this is where the rotation profile is flat. There are, of course, multiple changes of sign for $r<1.2R_\ast$ in all curves. However, those points are associated with the strong shearing regions that we have already discussed in Sect. \[sec:instability\]. After analyzing several time steps before, during, and after outbursts, we draw the following picture: The consecutive shock passages near the maximum of $\Omega$ cause the flow field to adjust such that multiple changes of sign are created in the derivative of the vorticity.


similar to this option was also discussed in @2013ApJ...770...67B. If, on the other hand, the KH instability itself is responsible for the enhanced accretion, AM should be transported mainly by turbulent stresses, as opposed to the wave transport through the mode mentioned above. We did not find clear signs of turbulence during the outburst, nor did we find evidence of the upper mode. It is, however, plausible that the AM transport is still accomplished by waves and the KH instability might trigger or enhance a mode of the lower branch.

We did find evidence for the existence of a KH instability during the outburst. We consider for this purpose Fig. \[fig:vorticity\_outburst\], a 2D image of the $z$-component of the vorticity $\nabla\times\vec{u}$ at orbit $172.6$, i.e. at the peak of theresponsible for the frequent outbursts.

Angular momentum transport by waves
-----------------------------------

In Fig. \[fig:Mdot\_Jdot\_of\_t\] we visualized the total AM flux in the disk, which consists of the advective part, the viscous part in the disk, and the Reynolds part (see Eq. (\[eq:AMflux\])). It is, however, of great interest to see how much the instabilities contribute to the total AM flux and to deduce the efficiency of this transport. As we have described in Sect. \[sec:instability\], the instability in the BL leads to the development of acoustic waves that are launched from the interface and propagate into the disk and the star. As a consequence, AM transport in our models is dominated by acoustic radiation, i.e. sound waves carrying AM. We do not observe any turbulence in our simulations and hence rule out turbulent stresses


three distinct patterns that can be related to the three branches of the instability of a plane parallel vortex sheet and do not die out for the whole simulation time.

Additionally, the system repeatedly undergoes outbursts where the wave activity as well as the AM and mass transport increase considerably. We argue that these outburst are likely triggered by a secondary KH instability that develops in the flat region of the azimuthal velocity profile due to several changes of sign of the vorticity. Since the effective temperature also shows strong variations during outbursts, they may play an important role in explaining variations in the light curve, such as FU Or-outbursts or DNOs and QPOs in the case of BLs around white dwarfs. It is tempting to associate these phenomenamomentum is transported via turbulent stresses. This is a local process that also depends on the shearing at this point and a local effective viscosity can be derived by the model of . Furthermore, it allows for efficient mixing of the gas through the turbulence. In contrast, the AM transport we have investigated in this work does not depend on the local shearing, for instance, but is a non-local mechanism, instead. Therefore, it is doubtful whether a conventional $\alpha$-model is applicable in the BL, and it will be hard to give a simple parametrization for the AM transport in the BL at all. However, $\alpha_\text{Re}$ features a rather smooth behavior and might be utilized for a simplified picture of the stresses in the BL. In addition, the mixing


prion or prion-like states, and that some of these prions can be beneficial.[@R1]^,^[@R3]

Most known prion-forming proteins contain conserved functional domain(s) responsible for the protein's cellular activity, and a much less conserved prion domain that is responsible for aggregation and maintenance of the prion state. Several distinct structures have been described for prion domains of amyloid-based prions. All of them contain an ordered and extensive network of intermolecular bonds. Curiously there are many different self-seeding amyloid forms possible for most prion proteins. These different forms are called prion variants and often result in distinct phenotypic and biochemical properties.[@R1]^,^[@R4]

The most common type of prion domain is characterized by a very high proportion of polar uncharged glutamine and asparagine (Q/N) residues. Low complexity of primary structure and, especially, a low contenta \[*pin^-^*\] strain.[@R12]

To see if other Q/N-rich proteins engage in both positive and negative prion-prion interactions, we used a candidate approach. Candidates included the proteins and protein fragments identified in the Derkatch et al.[@R12] screen as being able, when overexpressed, to promote the de novo formation of \[*PSI^+^*\]: Ste18, Yck1, Pin2, Pin3, Ure2, Nup116, Lsm4, New1, the C-terminal parts of Pin4 (Pin4C), and Cyc8 (Cyc8C), and the N-terminal part of Swi1 (Swi1N). We now tested these hits from the positive prion-prion interaction screen for the ability to cause the loss of pre-existing \[*PSI^+^*\], and almost half of them did: Pin4C, Cyc8C, Ste18, Yck1, and Pin2. Interestingly, the proteins engaging in the negative interaction with \[*PSI^+^*\] were among the strongest inducers of \[*PSI^+^*\]. Furthermore, the destabilizing effect of the


Ade^+^ phenotype, the colonies become white or pink. \[*PSI*^+^\] propagates stably, as shown by pink (Ade^+^) \[*PSI*^+^\] colonies (left). Upon Pin4C overexpression, red (Ade^-^) \[*psi^-^*\] colonies frequently appear (right). (**C**) Enlargement of visible \[*PSI*^+^\] aggregates upon Pin4C overexpression. Sup35 coalesces to small dots in \[*PSI*^+^\] cells expressing GFP-tagged Sup35 under the control of the native *SUP35* promoter (left). These dots enlarge upon overexpression of Pin4C (right; Sup35). Appearance of enlarged Sup35 foci coincides with the formation of large Pin4C dots, which do not co-localize with Sup35 aggregates (right; Pin4C; the same cell cluster is shown for Sup35 and Pin4C panels). Also, SDS resistant oligomers formed by Sup35 in \[*PSI*^+^\] cells (middle, left lane) enlarge upon overexpression of Pin4C (middle, right lane). (**D**) A shift of Hsp104 into Pin4Cchaperone titration lead to only a slight reduction of cytoplasmic levels of Hsp104 (to 74%), and to an insignificant reduction of Sis1 levels. Consistent with our data, such a small drop in Hsp104 levels is obviously insufficient to cure \[*PSI^+^*\],[@R34] but it may be sufficient for \[*URE3*\] destabilization. Indeed, experimental evidence suggests that the number of \[*URE3*\] propagons transmissible to daughter cells is less than the number of \[*PSI^+^*\] propagons, which could explain why \[*URE3*\] is more sensitive to the reduction of aggregate fragmentation and, specifically, to Hsp104 inactivation.[@R25]^,^[@R40]^,^[@R41] Thus, we hypothesize that curing of \[*URE3*\] by Pin3 is caused by Hsp104 titration ([Fig. 1D](#F1){ref-type="fig"}).

Several negative prion interactions were recently reported by the Nakamura and Yoshida labs.[@R25] They report curing of one or several yeast prions (\[*URE3*\] and, sometimes,


Busulfan-cyclophosphamide versus total body irradiation-cyclophosphamide as preparative regimen before allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia: what have we learned?
Most of the preparative regimens before allogeneic bone marrow transplantation include cyclophosphamide (Cy) with either busulfan (Bu) or total body irradiation (TBI). The Bu-Cy regimen has shown an advantage in chronic myeloid leukemia and TBI-Cy remains the standard conditioning regimen in acute lymphoblastic leukemia, but results are more conflicting in acute myeloid leukemia (AML). We report here the results of the most important studies comparing these two preparative regimens in AML. Survival is superior in all studies for patients treated with TBI and reached statistical significance in one of four trials. Two of three trials show significantly reduced transplant mortality and leukemia relapse. Higher incidences of veno-occlusivethat the information complies with the provisions of the
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(C) The information shall contain the official or customary citation of the statute and
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(D) In all court cases tried on an information, the issues at trial shall be defined by such
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  of the Public Access Policy of the Unified Judicial System of
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            regarding confidential information and documents.

            (b) The motion shall include the court, caption, term, and number of the
            case in which relief is requested.

            (c) The motion shall state with particularity the grounds for the motion, the
            facts that support     (1) Except as provided in Rule 906 (Answer to Petition for Post-Conviction
      Collateral Relief), an answer to a motion is not required unless the judge orders
      an answer in a specific case as provided in Rule 577. Failure to answer shall not
      constitute an admission of the facts alleged in the motion.

      (2) A party may file a written answer, or, if a hearing or argument is scheduled,
      may respond orally at that time, even though an answer is not required.

      (3) A written answer shall comply with the following requirements:


Impotence, Erectile Dysfunction, Low Sex Drive, Other Propecia Side Effects May be Long-Lasting

It’s becoming increasingly clear that men who use Propecia run the risk of developing severe sexual side effects, including impotence, erectile dysfunction, lower sex drive, infertility, testicular pain and genital shrinkage. Unfortunately for many men, recent research indicates that Propecia sexual side effects often continue long after they stop taking the baldness drug.

Propecia belongs to a class of drugs known as 5-alpha reductase inhibitors, or 5-ARIs. The active ingredient in Propecia can interfere with male hormones, including testosterone derivatives. According to a report from the Brisbane Times, a study published in the Journal of Sexual Medicine in July found that the majority of men who report Propecia sexual side effects continued experiencing problems for at leastinstitutions, group homes for independent living, and foster care and family homes. The children were removed from their families because the authorities determined that their parents were either unable or unwilling to care for them properly.

“It’s heartbreaking to see children crammed into institutions and deprived of the chance for life in a caring family setting,” said Kanae Doi, Japan director at Human Rights Watch. “While other developed countries place most vulnerable children in family-based care, in Japan, a shocking 90 percent end up in institutions.”

The 119-page report, “Without Dreams: Children in Alternative Care in Japan,” is Human Rights Watch’s first major report on Japan since the launch of its Tokyo office in April 2009. The report examines the alternative care system’s organization and processes, problems found in the


intermediates, including DAG, acyl-CoA, and ceramide is thought to drive the progression of NAFLD in humans.
Existing treatments for NAFLD demonstrate various deficiencies. For example, available drugs such as vitamin E, pioglitazone, and pentoxifylline have borderline efficacy, but are limited by potential side-effects and toxicities, and do not improve liver fibrosis. Weight gain is common in patients taking thiazolidinediones, and these drugs can cause fluid retention and precipitate congestive heart failure. Rosiglitazone use is also associated with increased risk of myocardial infarction.
A genetic link to NAFLD has been studied but has not been found. NAFLD is more frequent in East Asian Indians, followed by Hispanics, Asians, Caucasians and less frequent in African Americans. While such racial disparities are not fully understood, it is known that African Americans have lowerFormer Australia Test great Michael Hussey believes all-rounder Hilton Cartwright will fill the number six batting berth for the start of the Magellan Ashes Series next week, but has urged national selectors to seriously consider the recent form of his ex-national and state teammate, Shaun Marsh.

The National Selection Panel will convene later today to finalise Australia’s squad for the first two Tests against England in Brisbane and Adelaide – to be announced on Friday - and they are expected to reserve the right to make additions to that squad for the day-night Test at Adelaide Oval if required.

Appearing on The Unplayable Podcast prior to Western Australia opener Cameron Bancroft posting a double-century in the JLT Sheffield Shield match against South Australia yesterday, Hussey backed opener Matthew Renshaw to


enriched in the transcriptomes of mice and rats exposed to different stimuli. The stimuli included: social aggregation, sleep deprivation, stress, psychostimulants, antidepressants, anticonvulsants, and antipsychotics. Transcriptomes from cortices of animals exposed to social aggregation and psychostimulants were enriched for IFN-γ regulated genes ([Fig. 1h](#F1){ref-type="fig"}, [Extended Data Fig. 4](#F7){ref-type="fig"}, and [Supplementary Tables 2](#SD2){ref-type="supplementary-material"}, [3](#SD3){ref-type="supplementary-material"}).

A substantial number of meningeal T cells are capable to express IFN-γ (41.95% ± 6.34 of TCR^+^ cells; [Extended Data Fig. 5a](#F8){ref-type="fig"}) and recent work has proposed a role for IFN-γ in T cell trafficking into meningeal spaces^[@R16]^. To assess the potential role of IFN-γ in mediating the influence of T cells on social behavior, we first examined the social behavior of IFN-γ deficient mice and determined that they had social deficits ([Fig. 2a](#F2){ref-type="fig"}). Importantly, IFN-γfound that they had a similar social deficit as *Ifng*^−/−^ mice ([Extended Data Fig. 6c](#F9){ref-type="fig"}), which, as expected, was not rescued by injecting recombinant IFN-γ into the CSF ([Extended Data Fig. 6d](#F9){ref-type="fig"}). Based on our previous demonstration of a role for IL-4 produced by meningeal T cells in spatial learning behavior^[@R1]^, we assessed whether deficiency in IL-4 would also result in social deficits. IL-4 deficient mice did not demonstrate social deficits; in fact, they spent more time investigating a novel mouse than a novel object as compared to wild-type mice ([Extended Data Fig. 6e](#F9){ref-type="fig"}).

To determine which cell types in the brain respond to IFN-γ, we analyzed mouse PFC for the expression of IFN-γ receptor subunits 1 and 2 and found that both neurons and microglia express mRNA and


co-evolutionary pressure to increase an anti-pathogen response as sociability increased, and that the IFN-γ pathway may have influenced this co-evolution. To test this hypothesis, we analyzed metadata of publically available transcriptomes from multiple organisms including the rat, mouse, zebrafish, and fruit flies. Using GSEA, we determined transcripts from social rodents (acutely group-housed) are enriched for an IFN-γ responsive gene signature ([Fig. 3a, b](#F3){ref-type="fig"}; [Supplementary Tables 3](#SD3){ref-type="supplementary-material"}--[7](#SD7){ref-type="supplementary-material"}). Conversely, rodents that experienced social isolation demonstrated a dramatic loss of the IFN-γ responsive gene signature ([Supplementary Tables 3](#SD3){ref-type="supplementary-material"}--[7](#SD7){ref-type="supplementary-material"}). Zebrafish and flies showed a similar association between anti-pathogen and social responses ([Fig. 3c, d](#F3){ref-type="fig"}). We observed that immune response programs were highly enriched in the brain transcriptomes of flies selected for low aggressiveness traits (a physiological correlate for socially experienced flies^[@R21]^; [Fig.Ley (La Jolla Institute of Allergy and Immunology, San Diego, CA). Mice were given two separate injections (*i.p.*; 0.2mg in saline per mouse), four days apart, of either anti-VLA4 or rat anti-HRP for control (clone HRPN; BioXcell), then tested twenty-four hours post final injection.

Dissection of meninges and flow cytometry {#S12}
-----------------------------------------

Meninges were dissected as previously described^[@R40]^. Briefly, after sacrificing and perfusing, skulls caps were removed by making an incision along the parietal and squamosal bones. The meninges were removed from the internal side of the skull cap and gently pressed through a 70 μm nylon mesh cell strainer with sterile plastic plunger (BD Biosciences) to isolate a single cell suspension. Cells were then centrifuged at 300g at 4°C for 10 min, resuspended in cold FACS buffer (pH 7,4; 0.1


In total, 41 transcriptomes were analyzed as indicated in [Supplementary Table 2](#SD2){ref-type="supplementary-material"}. The statistical analysis was performed by evaluation of nominal *P*-value and NES based on 1,000 random sample permutations. Zebrafish are social fish that aggregate into shoals^[@R51]--[@R54]^. Various Zebrafish strains differ in their preference for social interaction and novelty, resembling the phenotypic variation of inbred mouse strains^[@R55],[@R56]^. Notably, domesticated zebrafish strains demonstrate higher social interaction and social novelty preference^[@R57]--[@R59]^ compared to wild zebrafish strains. Therefore, a GSEA algorithm was used to identify the enrichment of Zebrafish IFN-γ transcriptional signature in the publicly available whole-brain transcriptomic profiles of behaviorally distinct strains of domesticated and wild zebrafish ([Supplementary Table 7](#SD7){ref-type="supplementary-material"}). The brain transcriptomic profiles of domesticated (Scientific Hatcheries (SH) and Transgenic Mosaic 1 (TM1)) and wild (Nadia, Gaighata) zebrafishperformed by evaluation of nominal *P*-value and NES based on 1,000 random gene set permutations.

Promoter Motif analysis {#S23}
-----------------------

A GSEA algorithm was used to identify genes that are differentially expressed in brain transcriptomes of mice and rats exposed to social aggregation, domesticated Zebrafish strains and low-aggressive Drosophila melanogaster populations, compared to their control counterparts. High-scoring differentially expressed "leading-edge" social genes were selected based on their presence in the IFN-γ and pathogen-induced transcriptional signatures. Specifically, as shown in [Figure 3](#F3){ref-type="fig"}, we have identified 31, 48, 14, 53 leading-edge genes in brain transcriptomes of mice and rats exposed to social aggregation, domesticated Zebrafish strain, and low-aggressive Drosophila melanogaster population, respectively. We next, extracted promoter sequences of 200bp up-stream of TSS of these "leading edge" genes using UCSC Genome Browser (<https://genome.ucsc.edu/>). The


NeuN^+^ neurons, not Iba^+^ microglia (top = 20×; bottom 63× Objective).](nihms793134f12){#F12}

![IFN-γ increased the number of c-fos+ cells in Layer I of the PFC\
**a,** IFN-γ was injected into the CSF (*i.c.m.)* 2 hours prior to sacrificing and processing brains for immunohistochemistry. Slices were stained for c-fos. Atlas image adapted from: c 2015 Allen Institute for Brain Science. Allen Brain Atlas \[Internet\]. Available from: <http://www.brain-map.org>. **b,** Total c-fos^+^ cells in layer I of the PFC (*n* = 3 mice per group; \* *P* \< 0.05). Holding current pre and post IFN-γ application on acute slices from the PFC (**c**) and somatosensory cortex (**d;** *n* = 6 neurons from 3 mice). **c,** *Vgat*^Cre^::*Ifngr1^fl/fl^* mice. IFN-γ increased tonic inhibition in Cre- mice (*n* = 6--7 cells from 4 mice per group; \*\*with the following change:
     pipe_in.close
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+pipe_in.close
+pipe_out.close
+
 Process.wait
 Process.wait

Without this change, you still have the pipes open in the original process, so the reader will never see an end of file.  That is, process doing the wait still had the write pipe open leading to a deadlock.


parking is available on site.
The accommodation comes with a seating area with a flat-screen TV, CD player, and Blu-ray player. Some units include a dining area and/or terrace. All units have a kitchen equipped with a dishwasher and oven. A microwave, a coffee machine and a fridge are also featured. Each unit is equipped wi[More...]

Situated in Magny-le-Hongre, B&B Hôtel à Disneyland® Paris offers accommodation 34 km from Paris with free high speed WiFi and free private parking available on site. Additional facilities include vending machines and a gift shop.
Rooms are air-conditioned and feature satellite TV and Bultex mattresses. A private bathroom is included in each room and is equipped with a shower and toilet.
The buffet breakfast offers a wide range of hot drinks, f[More...]

Located 10 km from Disneylandnothing more than the ignorant opinions of a few politicians. Similarly, Republicans in the Montana state legislature recently introduced a bill which stated, among other scientific falsehoods,

"global warming is a natural occurrence and human activity has not accelerated it."

It seems as though Republicans think that politics can dictate science. Unfortunately, passing legislation saying that humans are not causing global warming, or that greenhouse gas emissions do not pose a threat to public health and welfare, does not change the physical reality that these statements are simply wrong.

The climate operates based on the laws of physics, not the laws of Montana or the United States of America. Republicans may have declared war on science, but it's a war they cannot win. By pretending that we can dictate how the


contraception & improved health care (which doesn't need to be heavily energy dependent). Energy plays a role, of course, but doesn't actually have to be in fossil fuel form-as Iceland proves quite nicely.
Also, a graph by the International Energy Agency (which I currently can't find the link for) shows very little correlation between energy use per capita & per capita GDP.
Last of all, Gilles, the EU-27 countries achieved around a 15% reduction in total energy consumption-across all sectors of the economy (industrial, commercial, domestic & transport)-without any detriment to GDP growth. Of course, these same EU-27 countries have also significantly reduced their consumption of electricity from fossil fuels. So, come on Gilles, where is this "mountain of evidence" proving that fossil fuel consumption automatically translates into freedom fromAfter all, the history of George W Bush's administration shows that you will not get to choose who the experts are. And seeking to establish governance by experts will just alienate the citizens of the nation.

Gary Thompson:
"Actually, the politicians are supposed to look out for the interests of the people who voted them in office. And many of those voters don't subscribe to the EPA regulations that are being defined and enforced by unelected bureaucrats. This may be hard to swallow for the AGW crowd but this is how Democracy works and that is how the Republic of the USA was set up."

Democracy actually requires a politician to think beyond the self serving, or it is a requirement outside the US. If you are saying that winner takes


and on toward the future, it does not make sense that we start to dig ourselves further into this hole. Advances are needed in other energy fields, and a phasing out of outdated tech is what will help us become more sustainable in the future.

#26: "... it alone of all governments reflects the equal moral worth of all people by giving all people an equal say in the governance of their nation."

Tom,
Perhaps you haven't been around US politics. The last guy who truly believed that statement worked in practice also said it would require that 'kings were philosophers and philosophers kings.'

Anyone who believes this is something new really must read Oreskes' Merchant of Doubt. She very clearly traces modern-era political attacks on the rules, if not the lawsof science, back to their Cold War origins. The difference now is that political willpower (Karl Rove) is matched by greed (Koch bros et al) and that combination has learned to play on popular fear (Beck, Limbaugh, Palin). Without an educated electorate, what chance does science, especially something complicated like climate science, have against that?

Marcus. I haven't seen an electric car for well over six months, do they even exist??? I heard rumors that a couple hundred of them were sold? There is absolutely no foundation to believe at this time that electric cars will displace any appreciable amount of oil. Is that what you use? The fact is that wind and solar only contribute a negligible amount of energy to our world, they replace even a more


All relevant data are within the paper and its Supporting Information files.

Introduction {#sec001}
============

The Aristaless related homeobox (ARX) protein, the vertebrate homolog of Drosophila Aristaless, is a paired-like transcription factor with temporally and spatially restricted expression in the developing central nervous system \[[@pone.0170282.ref001]\]. Mutations in *ARX* result in a broad range of neurologic phenotypes from severe structural anomalies of the brain with accompanying epilepsy and intellectual disabilities, to structurally normal brains having similar intellectual disabilities and epilepsy \[[@pone.0170282.ref002],[@pone.0170282.ref003]\]. Furthermore, there is a reasonably close correlation between the type of mutation in *ARX* and the associated phenotype \[[@pone.0170282.ref004]\].

During brain development *Arx* is expressed in neural progenitor cells (NPC) located in both the ventricular zone (VZ) of the pallium (neocortex) and the subventricular zone (SVZ) of the subpallium (ganglionic eminence, GE)\[[@pone.0170282.ref001],[@pone.0170282.ref005]\].mutant β-catenin (D164A) is too weak to activate the pathway.

We next mapped the interaction between BCL9 and ARX. Only full-length ARX and ARX (1--470) appeared to interact with GST-BCL9. Neither ARX (221--430) or ARX (431-564-3XSV40-NLS) showed an interaction, implying that the N-terminal region of ARX (1--220) is required for this interaction ([Fig 4F](#pone.0170282.g004){ref-type="fig"}). The fact that the ARX (431-564-3XSV40-NLS) failed to interact with BCL9 may partially explain why the transactivation activity of the D164A mutant co-expressed with ARX (431-564-3XSV40-NLS) was not fully recovered to the extent achieved with ARX (WT) ([Fig 4C](#pone.0170282.g004){ref-type="fig"}). Taken together, our data suggest that the inter-molecular interaction between ARX, BCL9, and β-catenin is crucial for optimal signaling activity.

While BCL9 is a co-activator of β-catenin and it binds to the N-terminus of β-catenin, there are


Solid-phase extraction of flavonoids in honey samples using carbamate-embedded triacontyl-modified silica sorbent.
In this study, carbamate-embedded triacontyl-modified silica (Sil-CBM-C30) is successfully prepared and used as an efficient sorbent for solid-phase extraction. The extraction performance of the resultant sorbent is evaluated with five flavonoids including myricetin, quercetin, luteolin, kaempferol and isorhamnetin. Main parameters, which affect extraction efficiencies, are carefully investigated and optimized. Comparative experiments between Sil-CBM-C30 and commercial C18 sorbents indicate that the extraction efficiencies of the former one surpass the latter one. The modification of carbamate-embedded triacontyl group on surface of silica causes analytes extracted by hydrophobic, hydrogen bonding and π-π interactions. Under optimal conditions, good linearities and satisfied LODs and LOQs are achieved. The SPE-HPLC-DAD method is successfully developed and applied for the honey sample analysis.workers who raise and process these animals for you to eat.

But before going into that, let’s look at the short and brutal life of a factory-farmed chicken.

Sickening animal abuse

“Chickens are arguably the most abused animals on the planet,” Sarah Von Alt, a communications specialist at Mercy for Animals, a Los Angeles-based nonprofit animal advocacy group, told AlterNet.

Whereas the life expectancy of a backyard chicken can be between 10 to 15 years, a broiler chicken lives for about 40 days. Chickens are social, intelligent creatures, capable of forming emotional bonds, but today’s broiler chickens are purposely bred into meat-producing machines.

Von Alt described how a broiler chicken’s unnaturally rapid growth rates causes incredible suffering as they are crippled and rendered immobile from their own weight. This leaves them in constant


and choke off oxygen in water that can harm or kill aquatic life.

Raising chickens for food also requires a huge amount of resources. It takes 2.5 pounds of grain and 518 gallons of water to produce one pound of chicken meat. Also, as Nina Rastogi wrote in a 2009 Slate article, “The poultry-broiler industry consumed some 240 billion megajoules of energy in 2005, or the equivalent of 42 million barrels of crude oil. That's more than the entire country of Sri Lanka consumed the same year—all to keep us well-stocked with wings and drumsticks.”

Environmentalists also have a major bone to pick with the meat industry’s role in global deforestation, due to sheer amount of grain that’s necessary for animal feed.

“In South America, almost 4 million hectares of forestsStates 12 km to the North of the urban zone of the city.

In December 2013 the streams that cut the city overflowed causing havoc all over town, many people lost all furniture, home appliances and car dealers lost goods and many other havoc were recorded.

São Mateus River
Ilhéus Stream
Turvo Stream
Cold Stream
San Francisco Stream

Districts
Barra do Ariranha, Limeira de Mantena,Santa Rita and municipal seat.

Neighborhoods

Alvorada, Bela Vista, Boa Esperança, Centro, Colina, Ebenézer, Esplanada, Frei César, Nicolini,Operários, Philadelfia, Pires de Albuquerque, Santo Antônio, Santos Prates one, Santos Prates two, São Bernardo, São Silvano, Treze de junho, Treze de maio, Tropical, Vila Florindo, Vila Nova, Verli allotment and Maulaz allotment.

List of municipalities in Minas Gerais

References

Category:Municipalities in Minas Gerais


elevations to
  this one of Venus.)

In summary, while Venus has plate tectonics they are radically different from those of planet Earth.
Th key factors for plate tectonics on any planet can be summarized as the following.
Necessary planetary differences:
Factors that make each world unique.
Heat sources: Magnitude and relative contributions of different heat sources (primordial, radiogenic, tidal)
Size: Surface/vol ratio determines rate of cooling.
Resurfacing: Presence and rate of resurfacing processes like impacts or erosion, transport, and sedimentation that mask crustal tectonic processes.
Rate and extent of cooling: How prevalent is volcanic activity? How thick has the lithosphere become. Does an asthenosphere exist at all?
These factors can be compared with those of Earth's.

Earth: Recall the distinctive features of Earth's lithosphere:
Active plate tectonics: Rigid lithospheric plates move overon the United States and the EU for the turmoil in Ukraine.

“The people [of Ukraine] are in essence being pushed into the abyss of fratricidal war,” Russian news agencies quoted Lavrov as saying at a ministry reception attended by the head of the Russian Orthodox Church, Patriarch Kirill.

Ukrainian Prime Minister Arseniy Yatsenyuk called on Russia's Vladimir Putin on Wednesday to block the border to Ukraine to prevent separatist fighters from entering the country.

He said that if Russian influence was eliminated, the crisis could be ended swiftly.


Highlights

This spy sport glasses let you record high quality undercover videos without anybody knowing. That’s because the tiny pinhole camera is well hidden into the frame itself with reflective coating on glasses. So even under close examinations no one will ever suspect a thing.This spy sport glasses comes with remote control for easy operation, and it records stunning HD videos at 1280x720 30FPS. Using this device is quick and easy too. Press a single button once to record and press it once more to stop video and save.    class Case2Type,
           class DefaultType
          >
  struct ct_switch4
  {
    typedef mpl::identity<Case0Type> Case0TypeQ ;
    typedef mpl::identity<Case1Type> Case1TypeQ ;

    typedef equal_to<Value,Case0Val> is_case0 ;
    typedef equal_to<Value,Case1Val> is_case1 ;
    typedef equal_to<Value,Case2Val> is_case2 ;

    typedef mpl::if_<is_case2,Case2Type,DefaultType> choose_2_3Q ;
    typedef mpl::eval_if<is_case1,Case1TypeQ,choose_2_3Q> choose_1_2_3Q ;

    typedef typename
      mpl::eval_if<is_case0,Case0TypeQ,choose_1_2_3Q>::type
        type ;
  } ;

  // Metafunction:
  //
  //   for_both<expr0,expr1,TT,TF,FT,FF>::type
  //
  // {exp0,expr1} are Boolean Integral Constants
  // {TT,TF,FT,FF} are


 typedef mpl::eval_if<caseTF,TF_Q,choose_FT_FF_Q> choose_TF_FT_FF_Q ;

    typedef typename mpl::eval_if<caseTT,TT_Q,choose_TF_FT_FF_Q>::type type ;
  } ;

} } } // namespace network_boost::numeric::convdetail

#endif

Turing Apples featuring Garosu Girls! November 27 2013

Hong Kong is full of local creativity and talent. We are very fortunate to have come across local indie rock band Turing apples. The musical love child of Hans, Ali, Nicola, Lat and Rafe's, together they have written melodic and catchy original songs. They are the sound of all the Garosu Girls' videos, more to be revealed soon. In return, we support their performances with jewelry for their lead singer, Niki. (We hope to dress the male members of the band soon too)


M.W. Pender

I was in Athens, Greece in 1992 visiting with a fellow MBA schoolmate. He was then working in marketing with a large US corporation. I asked him how Greece as a country was doing? He said that if the wealthy would pay their share of taxes, it would be a lot better.
The IMF and the World Bank shoul...

Guest - jim

George Will should hang out with Oliver Blanchard. Blanchard wrote in his blog that Greece spends 16% of its GDP on pensions(numbers surely inflated by the amount of austerity the IMF proposed) and then questioned "why have a pension system?" truly scary to think how clueless the IMF is.

The usually insightful Matt Yglesias takes a big swing and a miss in his effort to explain why it appearsthen Dan Snyder will have to put tens of millions of dollars on the table to get someone like Peyton Manning or Tom Brady to move over from their current team. That is the way labor markets work. This means that if a software designer in Silicon Valley needs top quality engineers then he or she will have to pay enough money to get them to leave Google, Facebook, or wherever else people with the necessary skills might be working.

We are still not seeing rapid wage increases in any major sector of the economy. This implies that either there are not real shortages, just whiny employers, or alternatively we have employers that are so ignorant of the workings of the labor market that they don't realize they can


attract more skilled workers by offering higher wages.

Recent comments

Here's a theory. Call it New York City Landlord Economic Bias. Rents steadily soar in NYC in part because landlords -- independently of one another and en masse -- assume that rents must always go up. It doesn't matter what's happening with their costs or with the ability of tenants to pay; rents mu...

Guest - MacCruiskeen

Even for star athletes there's a business rationale behind those numbers--the owner wants a winning team that will sell tickets, merchandise, and ads on tv broadcasts. So they have to think, how much will Peyton Manning or LeBron James or whoever is the it guy of the moment increase that revenue? An...

It is an old problem:
Proverbs 20:14 "It's no good, it's no good!" says thethe price basket, but not the initial cost.) With an important qualification that we will get to momentarily, we can assume the benefits are greater than the cost since people opt to buy cell phones, but that gap is much less than just counting the benefits alone, which it seems is how our elite economists view the issue.

The second point is that we adjust our society and living patterns around the technology we have. Ask someone who lived in the suburbs in the 1960s how they would feel living without a car. It would be pretty awful, but just 30 years earlier most middle class families did not have a car or think they needed one. To take a slightly more recent example, imagine living without air conditioning


in 1980 was the equivalent of $100,000 today so I know what life was like in New York on that salary. I could not afford a house because of super high interest rates and high down payment requirements. Taxes were much higher than today and the infrastructure in the metro region was terri...

To answer some of the negativism above.
USA infrastructure has never been better, it is certainly better than it was in 1980. There are only a few countries with better (Germany, Japan, Switzerland and maybe a few more.)
The war on poverty was won. See: http://conversableeconomist.blogspot.com/2013...

Wow, it's the sharing economy, everything is new and different. Hey, they don't have to pay the fees that those stupid old taxi companies do, because you order them on the Internet.

Sorry toQ:

Rewrite URL but keep external files

I've been making a web app with PHP but the problem is that when I try to rewrite:

http://example.com/user.php?username=user121

to:

http://example.com/user/user121

with HTACCESS, it loses all external files and only keeps the page's HTML. Please help me out?
My current Rewrite Rule:
RewriteRule users/([^/]+) user.php?username=$1 [NC,L]

A:

Use any one of these solutions.
Solution 1:  use absolute path in your css, js, images files rather than a relative one. Which means you have to make sure path of these files start either with http:// or a slash /.
Solution 2: Try adding this in your page's HTML header:
<base href="/" />

Solution 3: Add this rule in your .htaccess:
RewriteRule users/(.+?\.(?:jpe?g|gif|bmp|png|tiff|css|js))$ /$1 [NC,L,R=301]


comes into play, she is the main suspect in the murder. She turns out to be more than a suspect, she is a Soul Seeker. Follow Andrew as he tries not to fall into a web of lies, deceit and death.

Mr. Pizza

By J.F. Pandolfi

Most people make at least one really harebrained decision in their life. Just ask Tony Piza. Deciding he needs a “paid vacation” for a year after college, Tony lands a job teaching at a Catholic elementary school…defined as the number of correlations of the measured variables in the two phases, concentration and shooting. A positive relationship was demonstrated--the higher the factor, the better the performance. In addition, the stability of the factor was greater within the best marksmen and archers group. A model of the temporal change of the percepto-effector factor in both groups was given in three dimensions. This modelling of performance characteristics gave a visual indication of the differences between best/worst performances.


same time, Fleetcor decided to implement a “network service fee,” which has further irritated AllStar customers.

According to a January report in Fleet News:

“AllStar fuel card customers are becoming increasingly frustrated with accessing online information and contacting call centre staff. Fleet managers have reported having to wait more than 30 minutes to have calls answered, while not being able to access information via the company’s website.”

The problems experienced (and the level of customer frustration as evidenced in the “comments” fields below the referenced news stories) shed light on the importance of the data stream that underlies the payment system in fuel cards. Facilitating the payment is the easy part of the process; fleet managers have come to rely heavily on the flow of operating data which has been interruptedNeurodevelopmental outcomes of children born to mothers with epilepsy.
Most children born to women with epilepsy are normal, but there is an increased risk of abnormal functional neurodevelopment in these children. Although there are many contributing factors, antiepileptic drugs (AEDs) may play a role. Most women with epilepsy must take AEDs during pregnancy because the potential for injury from seizures to both mother and fetus is a greater risk. AEDs are also used to treat other disorders, including depression and pain. Thus, an understanding of the effects of AEDs on the unborn child is relevant to physicians who treat nonepileptic mothers as well. This review discusses animal and human studies of the neurodevelopmental effects of AEDs and briefly reviews the possible mechanisms underlying these effects. Flaws in the methodology


teachers, some of who tutored and later tried to seduce students through the Internet, made up nearly 10 percent of the offenders. Special Ed teachers also made up 10 percent of the offenders.

The average victim is a 15-year-old female high school student in Brooklyn, where 36 percent of the abuse cases occurred. The average age of an offender is 39.

Seventy-five percent of the victims are girls.

Nearly 20 percent of the offenders are homosexuals and in most of these cases, the attack led to sexual relationship with the student.

When these numbers are added to another 347 substantiated sex abuse cases that have been probed by the Board of Education’s Office of Special Investigation between January 2000 and July 20, 2001, the statistics become even more staggering.

When The Post addednão deve ser utilizado isoladamente

        virtual int a() = 0;
        virtual int b() = 0;

        int c()
        {
            return b();
        }

 };

class A : public MyClass
{
    public:
        int a() { return 1; }
        int b() { return 1; }
        int


key is the tool to use and the last key is the scope. For instance SPC s a b will search in all opened buffers using ag .

If the last key (determining the scope) is uppercase then the current word under the cursor is used as default input for the search. For instance SPC s a B will search with word under cursor.

If the tool key is omitted then a default tool will be automatically selected for the search. This tool corresponds to the first tool found on the system of the list g:spacevim_search_tools , the default calling sequence is rg , ag , pt , ack then grep . For instance SPC s b will search in the opened buffers using pt if rg and ag havehigher risk, as measured by volatility. The return on a risky asset should be better when a light shines on the risk, says Gregg Fisher, founder and chief investment officer of New Yorkbased money management firm Gerstein Fisher. Small-cap stocks also have benefited from the fact that they outperform large-cap stocks during secular bull markets. Says Jeffrey Saut, chief investment strategist at Raymond James in St. Petersburg, Florida: Small-cap stocks can grow faster. At a certain size, its difficult to grow 40 to 60 percent.

To be sure, the five-year surge of small-cap stocks has pushed them to historically expensive levels, based on price-earnings ratios. As of March 18, the Russell 2000 traded at 23.2 times 2013 earnings and 19.6 times 2014 earnings estimates, says Chalupnik. The S&P 500


minutes."

The Crown said MacMillan then left the bar for about 45 minutes, leaving the woman alone with De Jesus Carrasco. Nathanson told the jury the woman began to show "increasing signs of intoxication ... Her walk and balance appear to become more wobbly."

The crown told the jury the video will show De Jesus Carrasco pulling the woman over to the bar and slapping "her 10 times on the face — to which she barely seems to react." He then allegedly positioned her head on the bar over what appeared to be cocaine.

After MacMillan returned, the prosecution alleges, both men engaged in sexual acts with the woman, who "appears to be physically overpowered, and the sexual activity is forceful and rough."

The Crown told the jury in addition to theIt is a widely held belief that anal sex is “gay sex.” In other words, people tend to assume that anal sex is an activity practiced almost exclusively by gay men. However, this is not an accurate reflection of reality. In fact, research suggests that not only has anal sex become increasingly common among heterosexual men and women, but the vast majority of people who practice it are not gay.

For instance, according to the National Survey of Sexual Health and Behavior (NSSHB), a nationally representative U.S. sex survey published in 2010, as many as 27% of guys aged 25-49 reported having practiced insertive anal intercourse in the past year (i.e., they inserted their penis into someone else’s anus) [1]. When you consider that only 4.2% of men in


ate." "You need to eat more for your strength." "Where's Sang-hwan?" "He's not eating." " Sang-hwan!" "Come out!" " Leave him alone." " Hey, Sang-hwan." " Stop bothering him!" "We should eat together." "We are not a big family." "His dad is here." " Hey!" "Sang-hwan!" " Just eat!" "I just ate..." "Eat anyways." "At your age, you could even chew on stones." "Where are you?" "Wait at your place." "I'm hanging up!" "Hang up!" "It's for indigestion." "I wouldn't dare tell you to live like me." "But you should think of" "your grandma..." "Here." "Have one." "Cover your hand when you are in front of elders." "The other parents agreed to settle." "And there's my savings..." "Thinking of that work I did at that site," "I canpleaded"; that the court erred "in denying Federal's motion for leave to amend" its grounds of defense to plead that defense; and that the *686 court erred "in ruling that Federal is estopped from asserting the contractual one (1) year limitations period defense". Because we conclude that the court's estoppel ruling was correct, we do not reach the other two rulings.
On brief, Federal argues that the estoppel ruling was in error "because Federal acted reasonably and in good faith in discovering that the parties were litigating an incorrect copy of the payment bond." The delay in the discovery, Federal says, was due to the fact that its own bonding agent "had sent incorrect copies to both Federal and Dixie after the bond was executed." As soon as Federal


The Dark Knight keeps surprising us... first, it was the movie itself. Now, some products related to the epic are getting some attention. Hollywood have always got some good merchandising for their movie, specially when the subject is Action Figures.

Action Figures have always been a big PART of our lives. Not our lives? Well, at least MY life. But if you can relate to that, than you'll probably get all jumpy when you get to see this sweet Joker action figure. Different from the first TDK action figures featuring the regular Joker outfit, this one features the Bank Robber version of our favorite villain.

Update: I forgot to post the picture where it shows all the accessories... there is also an extra head, so that's why his expression andShootout yet."

Bennett Selected for All-Star FieldFormer Angelo State point guard Ryan Bennett has been selected to play in the Orlando Invitational Basketball tournament in Orlando, Fla., July 6-8, 2009.

Farthing Earns Academic HonorCORAL SPRINGS, Fla. (July 1) -- Central Oklahoma's Raelynn Farthing has been named to the National Golf Coaches Association NCAA Division II All-American Scholar Team, it was announced Wednesday by the NGCA.

The tournament will be a four-person scramble with an 8 a.m. shotgun start and cost is $100 per player, which includes lunch and prizes. Awards will go to the top three teams, while closest to the pin and long drive contests will also be held.

Hole sponsorships are available for $600, which includes a team entry, sponsorship sign and special recognition.For more information, contact Coach Evans at


Craigslist has but one. I can’t promise you they’re not all from the same person. Here is the going rate for some Coldplay tickets.

Red section. $750 a pair.
Section 209. $500 a pair.
Section 418. $250 for one ticket.
Section 120. $998 a pair.
Section 110. $800 for a pair.
Section 334. $500 for a pair.
Section 223. $700 for a pair.
Section 201. $1350 for a pair. No that isn’t a typo.
Section 202. $500 for a pair.

Bell Centre seats from stub hub Coldplay.

I went to stubhub after that, just to see what their state of prices were. Stubhub can come through. Sorta. Their cheapest seats were $129 USD per ticket. Pretty comparable to the listings on kijiji. $500 a pair. More, actually.

I decided to do a little comparison. Let’s say you skipped Coldplay. WhatDr. Murray Feingold: Health care relies more on charitable donations

Tuesday

Aug 12, 2014 at 5:18 PMAug 12, 2014 at 5:18 PM

By Dr. Murray FeingoldMore Content Now

I am sitting in the dugout of the Boston Red Sox at Fenway Park. As I type this article on my laptop computer, I await the arrival of Hall of Fame legend, Carl Yastrzemski.What does this have to do with health you may ask?The reason why Yastrzemski is coming to Fenway Park is because he is participating in a charity event that both of us have been involved with for over 25 years - the Genesis Foundation for Children.Today, the health-care system is relying more on charitable dollars than ever before. In the past, more of the money spent on health care, especially for


approach reveals even more ramifications that are stretch credulity. If all the evidence of the world being more than 5778 years old is just how God made the world look, then it includes not only dinosaur fossils, but also artifacts of civilization from that period. Which means that the paintings of aurochsen and other animals in the Lascaux Caves were not painted by paleolithic cavemen, but were intead painted by God. Art by God!

So what do advocates of the prochronic approach think about such problems? I'll tell you the truth: they've never thought about them. One thing I will say in favor of Christian Young Earth Creationists is this: they have thought out their approach in detail. They might have crazy unscientific notions, but they've taken the timebut it is just a variation on the 5 minute theory that posits that you and everything else sprung into existence 5 minutes ago complete with a false set of memories to make you think you're much older. All your memories are false. Childhood scars? False. Your umbilicus? Never served a purpose, it's just there to make you look like it did. The world around you? Purpose built, with sediment layers, fossils and the like to look like it's billions of years old but it only came into being 5 minutes ago.It's a crazy theory but you cannot disprove it. Any proof you bring, I can throw into the "Yes, but it's just another false memory or artifact put there 5 minutes ago to make you think that".Now


amount of time ago. (you can't, but that is a different topic).

To propose that there is a different more "real" history that didn't involve any of these causes, but a Special Cause is of itself an irrational position. What makes that history more real than the implied version? I would say the implied version is more real. To be clear that means even in your thought experiment, once the world was created 5 minutes ago, all the history implied by the planted "false" memories etc. are actually the real history and your Creator would be the false one.

To be clear this is very different from creationism (young or old). Creationists, even of the variety critiqued by RNS argue that the overal evidence points towards their particular supported history.it would b better to spend time discussing things that need some rational understanding or where the Torah seems to clearly defy rational thought and science of which there is what to do deal with.

100 years ago they would have laughed at the idea of selling new clothing that look old, but now pre-stressed jeans are commonplace. Likewise, aged furniture. Is the concept of a world created already in motion so difficult? I don't think so.

Remember, we are operating under the premise that the world was created at a disctinct point in time. Is it reasonable to think that the sun was created, and yet remained dark for 8 minutes until its light reached us? Or that stars remained dark until, from light years away, their light finally


a proponent of the prochonic theory but it seems he didn't accept it entirely. For surely, one who can accept that Hashem has created a world with all the APPEARANCE of being millions of years old should also accept that the world was created to appear as if evolution has occurred over that whole time. So why object to evolution since it never really occurred (according to that view)? One who supports the five-minute theory should really have no problem accepting that diverse groups of animals evolved from one or a few common ancestors. I cant see how they can accept the former and not the latter.

For those that give any credence to the prochronic theory, read this wildly amazing fascinating article (https://mobile.nytimes.com/2017/10/16/science/ligo-neutron-stars-collision.html) and then consider that ifthat PHOs would reduce their charges for those people without subsidy cards by \$25 and for those with subsidy cards by \$10. In addition, all those eligible for the new, higher subsidy levels also became eligible for cheaper pharmaceutical services -- with the patient contribution for fully subsidised items falling to \$3 per prescription item.

In October 2006, a further change was made to the funding levels for PHOs, such that all those PHOs offering very low cost access (ie very low fees) became eligible for even higher levels of subsidies. At October 2006, this required zero fees for children under 6 years; a \$10 maximum for children 6--17 years and a \$15 maximum for all adults 18 years and over. Additional funding was provided to practices agreeing to


funding for primary health care, providing around \$300 million additional new funding per annum on top of an annual spend on general practitioner services of about \$337 million in 2002/03 \[[@B16]\].

Results
=======

Changes in Fees Paid by New Zealanders as a result of the Strategy
------------------------------------------------------------------

In this section we report on changes in fees brought about by the PHCS. Our focus is particularly on \'first contact services\' or general medical services, the funding of which accounts for around 70% of annual capitation funding provided for primary health care \[[@B17]\].

Figures [1](#F1){ref-type="fig"} and [2](#F2){ref-type="fig"}, and Tables [1](#T1){ref-type="table"} and [2](#T2){ref-type="table"}, show the mean invoiced fees for the patients that were continually registered with a practice and the changes in mean invoiced fees over time. These fees are for general medical consultations (ie, excluding maternity,subsidy cards) were already eligible for government funding to support primary health care prior to the introduction of the PHCS, while other groups were not.

In terms of changes in the average level of fees over time, in Access practices, there were falls of between 4 c for children with and without community services cards to falls of \$8.67 for those aged 65 years and over without community services cards. Percentage falls in fees ranged from 5% for children without community services cards, to between 11% and 26% for most other population groups, to 35% for those aged 65 years and over without community services cards.

New funding was introduced for Interim practices in October 2003 for those aged 6--17 -- with a \$5 increase in subsidy rates for those


socio-economic positions (except for children). For example, fees have fallen further for those aged 65 years and over without cards. This is because the aim of policy since 2001 has been to relate public funding for primary health care more closely to those who need care rather than to target it on those with the lowest incomes or highest level of past use as under the pre-PHCS approach.

With almost all practices becoming members of PHOs and with almost all New Zealanders now enrolled in a PHO, there is no definitive way of knowing how fees might have changed in the absence of increased funding for primary health care. Recent research by Cumming and Stillman (personal communication, J Cumming and S Stillman) shows that nominal fees paid by patientshis lieutenants. Because they were put on electronic storage devices it can't be known for sure if the messages were ever delivered.

As we reported earlier, CNN's Peter Bergen, who reviewed several hundred of the documents while researching his book Manhunt: The Ten-Year Search for Bin Laden From 9/11 to Abbottabad, says they:

"Paint a portrait of a man who was simultaneously an inveterate micromanager but was also someone almost delusional in his belief that his organization could still force a change in American foreign policies in the Muslim world if only he could get another big attack organized inside the United States — something some of his subordinates were quite skeptical about given al-Qaida's diminished capabilities."

We're updating this post with highlights and materials. Be sure to click "refresh" to


After putting wheels on the abode to make it portable, he decided to give it to a homeless couple one cold and rainy night

California Man Builds Portable Shelters on Wheels for Oakland's Homeless: 'I Wish That I Could Help Them All'

Know a hero? Send suggestions to heroesamongus@peoplemag.com. For more inspiring stories, read the latest issue of PEOPLE magazine

Gregory Kloehn was turning a condemned building in Oakland, California, into condominiums in 1998 when he noticed that some of the homeless people camping near his project had built themselves small shelters with cardboard, two-by-fours and sheets of plastic.

Get push notifications with news, features and more.

Every morning, when he returned to his job site, city sanitation workers would come by and clear the hovels away, forcing the occupants to go inthe hardworking men and women who comprise the film and television industry….”

The bills had strong backing from TV and film producers and a coalition of labor groups including SAG-AFTRA, the Directors Guild, the California Teamsters Public Affairs Council, Teamsters Local 399, Professional Musicians Local 47. IATSE and the Recording Musicians Association.


but he wasn't seeing the ball quite so well, and his eyes, hands and feet weren't working quite as smoothly as a collective unit. And the bowlers were making him work a lot harder for his runs.

Let's begin in England. At the start of that tour, Rahane had looked utterly bereft of confidence. At Edgbaston, he was the picture of uncertainty, his dismissals in both innings the result of being trapped in no-man's land: between leaving and playing in the first, between cutting and punching in the second. At Lord's, he was twice out feeling for the ball, hanging his bat out limply, away from his body, neither attacking nor defending.

Lengths England's quicks bowled to Rahane ESPNcricinfo Ltd

By then, Rahane had made 132 runs in his last 12Animals were housed and maintained according to the Ministry of Health of Iran for the care and use of laboratory animals, CCAC guidelines for care and use of experimental animals and IAUPS standard operating procedures. Investigation using experimental animals contained a statement confirming the adherence of the research to the principles of laboratory animal care (NIH publication, revised in 1985) and approved by the ethical committee of IAUPS.

*Animal Selection/Randomization*

The test population of animals was selected from newly arrived, previously unused mice. The method of randomization was based upon the random selection of numbers generated from a set of numbers without replacement.

*Preparation of Animals*

All animals used for the limit test were fasted over-night. Food but not water was withheld from 5: 00pm. On the day preceding dosing. In order


animals survived, four additional animals in each strain and gender were sequentially dosed at approximately 48 to 72 h intervals. A total of 20 animals were tested.

*2. Test Article Preparation*

Since the test article was a granule, they were used on "1 g/mL" suspension. The vehicle for preparing this suspension was distilled water.

*3. Dose Administration*

The animals were dosed at 2000 mg/kg (0.2 mL/kg by volume). The individual doses of the test article were individually calculated for each animal based on the body weight of the animals. All doses were administered orally using a feeding cannula, inserted into the stomach of the animals.

*4. Observations during In-Life Phase*

The animals were individually observed once during the first 30 min after dosing and periodically during the first 48 h following dosing (with specialexaminations*

Clinical signs were observed and weights were measured and recorded once daily in acute study and once weekly in subchronic study. The recording items were divided to three categories:

Cageside Observations contained home cage activity, feces color, feces amount, feces consistency, urine color, urine amount and behavior while removing from cage.

Neurological Examination analyzed tail elevation, abnormal gait, ataxic gait, and head position.

Physical Examination included death, hair coat, mucus membrane/eye/skin color, body temperature, respiratory rate, respiratory character, lacrimation, amount of salivation, and eye prominence.

*Biochemical assays*

Biochemical parameters were measured in three female and three male mice of high dose group and control group with an automated biochemical analyzer in the same laboratory and consisted of fasting blood glucose (FBS), low density lipoprotein (LDL), high density lipoprotein (HDL), fasting triglycerides (TG), aspartate


outside a sandbox:
ghc-pkg unregister --force regex-compat-0.95.1

If you are inside a cabal sandbox:
cabal sandbox hc-pkg -- unregister attoparsec --force

The first -- is the argument separator for hc-pkg. This runs ghc-pkg in a sandbox aware manner.

A:

There is also the cabal-uninstall package which provides a cabal-uninstall command.  It unregisters the package and deletes the folder.  It is worth mentioning though that it passes --force to ghc-pkg unregister so it can break other packages.

explained how it is using it for news. NAB had a dedicated section in the North Hall. Nokia showed its Ozo solution made of eight lenses. “VR featured on a good number of stands at NAB, but in many cases this was just to show that the products from these companies are capable of handling 360 video. The two areas of specialisation that have been particularly interesting are camera and stitching, both of which have seen advances in just the past few months, with companies such as Nokia and VideoStitch demonstrating very impressive live implementations of 360 video at NAB. Futuresource expects VR/360 video to generate $3.4Bn annually worldwide by 2020 and this NAB has confirmed that the technology is moving quickly enough to allow this,” explained Adam


Cox from Futuresource. From VR to virtual studios, weather programmes are still a front-runner, with an impressive set-up. The Weather Company now belongs to IBM.

Panasonic and Sony used to enforce how TV production worked

They invented videotape formats then file formats. They were used to shoot, edit and play TV programmes. Today, DPP (UK) and NABA (US/Canada) are defining the replacement formats. Some questions remain: are global actors really involved? By global, we mean outside London and the US. Was Germany, Europe’s leading market, at the table? Were there sufficient inputs from users, Chief Financial Officers (who ultimately make investment decisions for commercial media groups), etc.? Until you get your master format right, you can always use Cube-Tec MXF Legalizer to modify the technical aspects of your file.

With nativevoid write(int... a) throws IOException {
        File file = new File(fname);
        try {
            System.out.println("WRiting to-" + file.getAbsolutePath());

            if (!file.exists())
                file.createNewFile();
            file.canRead();

        } catch (IOException x) {
            x.printStackTrace();
        }
        BufferedWriter outputWriter = new BufferedWriter(new FileWriter(file));


that's their best way to counter Australia.

Mohammad Abbas celebrates after making the early breakthrough Getty Images

Inexperience in the attack a concern

It surprised me that so much inexperience was picked. In Mohammad Abbas you've got a very, very good new-ball bowler. Abbas can strike for you and dry up runs, so he gives you that balance. Shaheen Afridi is going to be an incredible bowler. He's coming off dengue fever so he hasn't bowled that much but he is the future, he's going to be very good. Then it will be who they bowl with those guys - you've got Imran Khan, and the youngsters - so that third seamer will be vital. I think Naseem Shah and Muhammad Musa will be very good bowlers, without a doubt, and<?php

/*
 * This file is part of PHP CS Fixer.
 *
 * (c) Fabien Potencier <fabien@symfony.com>
 *     Dariusz Rumiński <dariusz.ruminski@gmail.com>
 *
 * This source file is subject to the MIT license that is bundled
 * with this source code in the file LICENSE.
 */

namespace PhpCsFixer\Fixer\ControlStructure;

use PhpCsFixer\AbstractFixer;
use PhpCsFixer\FixerDefinition\CodeSample;
use PhpCsFixer\FixerDefinition\FixerDefinition;
use PhpCsFixer\Tokenizer\Tokens;

/**
 * Fixer for rules defined in PSR2 ¶5.2.
 *
 * @author Sullivan Senechal <soullivaneuh@gmail.com>
 */
final class SwitchCaseSpaceFixer extends AbstractFixer
{
    /**
     * {@inheritdoc}
     */
    public function getDefinition()
    {
        return new FixerDefinition(
            'Removes extra spaces between colon and case value.',


protein powders, and they almost always have that weird, chalky after-taste. This does NOT. In my opinion, this is the best protein drink by far. I absolutely love the taste (especially with milk rather than water) and it mixes very well. My mom got me hooked on the Pure Protein brand and I don't know if I'll ever switch! Absolutely recommend this to anyone out there who has tried many different brands and never found one that they love.

My wife and I have been drinking Pure Protein every morning for a year or so. It WAS very creamy and delicious, but without any warning or package redesign, the makers have changed the formula and we WILL be looking for a different brand. All it does now is foamThe Instructions

Write or type out the following instructions to accompany the mac and cheese kits. If you want, you can also print out the same one I made by right clicking on the photo below and saving it to your computer.

Directions: Whisk the powder into 1 ½ cups of water in a medium-sized pot over high heat. Put on the lid, and bring to a boil. Add the pasta and stir. Reduce the heat to medium, and put the lid on. Remove the lid to stir it every couple of minutes, and put the lid back on. After 15 minutes, turn off the heat and serve.

I printed 10 copies on regular printer paper (because I doubled the recipe and made 10 of these mac n cheese kits instead


can also be reused as a teacloth / kitchen towel / tofu-squeezing towel, and I like the idea of less waste. (Also, I miiiiight have a little fabric hoarding problem that needs to be dealt with.)

If you decide to try the furoshiki wrapping, just cut a 2 foot square piece of fabric, and serge or hem the edges. (I hemmed mine because I was too lazy to get my serger out.) Then set your cardboard instructions on the bottom in the center of the fabric. Set the cheese powder and the pasta on top, and wrap the furoshiki. If you’ve never wrapped a furoshiki before, you can find lots of tutorials online, or you can watch my video below to see how I did it.

☆☆☆☆☆☆☆☆☆☆surfeit of food, goods, and services that is unparalleled in history. North Americans spend less than 15 percent of their disposable income on food, the lowest percentage ever and anywhere, yet people complain about the prices.

Recently a good friend passed away at 92. He is the last of that generation who lived through the Depression and the Second World War (WWII). Like most who were directly and deeply involved he would not talk about his War experience. He talked with me because of my air force experience and interest in the tactical and military aspects. He flew fighter aircraft out of Gibraltar and North Africa in the defense of Malta, some of the most dangerous combat conditions of the War.

A retired Manitoba Judge attended a course I taught,


is seared on to the cloth with a technology that has yet to be explained. Not only can scientists and historians not reproduce the image using medieval technologies, they can’t reproduce it with modern technology.

Italian scientist Paolo DiLazzaro tried for five years to replicate the image and concluded that it was produced by ultraviolet light, but the ultraviolet light necessary to reproduce the image “exceeds the maximum power released by all ultraviolet light sources available today.” The time for such a burst “would be shorter than one forty-billionth of a second, and the intensity of the ultra violet light would have to be around several billion watts.”

2) The 3D capabilities of the image. The image of the man on the Shroud can be read by 3D imaging technology.He's an honorable man and I appreciate his service

Raddatz: Afghanistan deteriorated -- your concerns?

Bush: No question the violence is up because the Taliban is making firm moves. In Afghanistan, you said it is deteriorating? It is no question though, no question there is a need for more troops, which I announced earlier this fall, but also no question that we will succeed.

Raddatz: Did you ever imagine your presidency ending, and I know it's not over yet, without capturing Osama bin Laden?

Bush: We have done great damage to al Qaeda. We have denied them safe havens, a safe haven in Iraq. We are pursuing them in Pakistan. We have got them on the run. We're keeping the pressure on them full time. And do I wish we had brought


line 611 active MTB saddle features a longer, down-curved nose that gives technical riders additional seating positions for cornering and steep climbing. The saddle body features carbon fiber reinforced plastic with optimized wall thicknesses, Titanium Alloy rails, and is covered with SQlab's tough yet breathable K18 material with Kevlar reinforecement at the nose and wings of the saddle for crash protection.
With our exclusive active System, T-Beam allows the saddle to rock slightly with the hips when pedaling. This dampened lateral tilt allows the saddle body to follow the biomechanical movement of the pelvis on each pedal stroke. The result is a decrease of pressure on the sitbones and a mobilization of the spinal discs.
Additionally, SQlab's Stepped Design offers more support to the back which improves the biomechanical pedaling
How Wired Published Its GitHub Story on GitHub - llambda
http://www.wired.com/wiredenterprise/2012/02/github-revisited/
======
ghayes
I'd contrast this situation to Wikipedia, which allows unfettered access to
collaboration. The benefit of MediaWiki is that people can build their changes
directly on previous changes, being continually pulled into master.
Alternatively, Wikipedia suffers from authorities having less weight than
experienced editors with little domain knowledge (and constant fights against
vandalism, esp. on trending articles).

There is a likely a middle-ground between Wikipedia's open editing, and
GitHub's "what does it really mean to fork a story and make a pull request."
Interesting experiment none-the-less for Wired.

------
mcrider
Merging people's writing together doesn't seem to be as obvious as merging
people's code together -- code is a means to an end, so whatever is the best
solution should be merged into master. Writing is subjective, so if your
paragraphs cause a merge


Q:

No package 'cairo' found

I'm running Ubuntu 14.04 and trying to compile libgdiplus (following instructions at http://www.lovesmesomecode.com/20130719-compiling-mono-3-in-ubuntu/) in preparation to install NZBdrone.
Error occurs when running ./autogen.sh --prefix=/usr/local. (I followed all instructions prior to this.)
The instructions on this command say:

This will configure the compilation process and ensure your computer has all the proper libaries and dependencies installed. If you ran everything above, you should be good to go. If it fails on an error and indicates you are missing a libary or package, you may need to install a development version of that package, and then try to run the command again.

The error I receive says:

checking for CAIRO... no
configure: error: Package requirements (cairo >= 1.6.4) were not met:
No package 'cairo' found
Consider adjusting the PKG_CONFIG_PATH environment variable if you
  installedrefrigerant pressure that is lower than the refrigerant pressure of other indoor unit due to a pressure drop. This indicates that the flow amount of the refrigerant is non-uniform, so that the cooling or heating efficiency of the distant indoor unit is lowered compared with other room(s).
Accordingly, the present invention is directed to a method for controlling an operation of a multi-air conditioner that substantially obviates one or more problems due to limitations and disadvantages of the related art.
An object of the present invention is to provide a method for controlling an operation of a multi-air conditioner in which each room can be sufficiently air-conditioned although lengths and diameters of pipes connecting between an indoor unit and respective outdoor units are different from each other.
Additional advantages, objects, and


features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention. The objectives and other advantages of the invention may be realized and attained by the structure particularly pointed out in the written description and claims hereof as well as the appended drawings.
To achieve these objects and other advantages and in accordance with the purpose of the invention, as embodied and broadly described herein, there is provided a method for controlling an operation of a multi-air conditioner. The method includes the steps of: compressing refrigerant by a compressor provided in an outdoor unit and discharging thevery effective at storing your settings so you don't run into issues with losing profiles and settings. Personally, I think it's the biggest upgrade to the MatterControl platform since I started almost two years ago, and has made my life much easier.

If you'd like to revert to a previous version to test the probe, let me know and I'll email you a link. I'd need to see the Terminal Log and the usual files (G-Code, Model) to know what's happening there.

Do you mean you worked out the problem with the Cloud Library -> Purchased files or the probe? They're both what I would call "print problems," so I'm not quite sure what you mean.

As for reverting to the previous version, 1.6 uses the same Cloud functionality, so any


                        T.C. Memo. 1997-64

                      UNITED STATES TAX COURT

                 ASTRIDA TERAUDS, Petitioner v.
          COMMISSIONER OF INTERNAL REVENUE, Respondent

     Docket No. 10433-95.            Filed February 4, 1997.

     Astrida Terauds, pro se.

     Gary W. Bornholdt, for respondent.

   of the
                                 - 5 -

taxpayer claiming the exemption, the child must not have attained

the age of 19 at the close of the calendar year or must be a

student.    Sec. 151(c)(1)(B).

     During 1987, Sandra had not attained the age of 19 at the

close of the year.    However, she had a part-time job at a

supermarket during 1987.    Based on petitioner's testimony at

trial, Sandra's gross income from this job was "over $1,900"

during 1987.

     Petitioner presented no evidence to establish the total

support provided


$65,071 basis determined
by respondent. This was not addressed by petitioner in her
testimony.
                                 - 8 -

was no taxable event as to such stock.    Another contention by

petitioner is that, of the amounts listed above, two of the stock

sales listed, Harris Trust Co. in the amounts of $10,710 and

$14,917, were incorrect and should have been, respectively,

$4,310 and $5,967.   Petitioner presented to the Court a Form 1099

from the Harris Trust Co. of New York that reflected a cash

payment to petitioner of $5,967.50 during 1986; however,

petitioner failed to prove that this Form 1099 related to anyclaimed by petitioner totaled $3,955.86, the
correct rounded off figure should be $3,956. It follows that the
adjustment should be $2,883 instead of $2,884.

     At trial, respondent's examining agent testified that the

above table reflected two adjustments in the prepayments claimed

by petitioner on her return:    (1) Respondent increased

petitioner's withheld taxes from $1,055.97 claimed on her return

to $1,073 to reflect an additional $17 in taxes withheld on

petitioner's dividend and interest income that she had not

claimed on her return, and (2) the $2,899.89 levy that was

claimed by petitioner on her return as a payment was not allowed.

Because of these adjustments, $2,884 of the prepayments claimed

by petitioner was disallowed.    The agent further testified that,

subsequent to the filing of petitioner's 1987 return, respondent

applied the $2,899.89


 3,084.23      Sept.   17, 1993
           54,532.26      July    17, 1991
          $59,195.83      Total   levies for 1986 tax year

     For the 1987 tax year:

         $3,823.00        Sept. 17, 1993

     The Federal income tax returns of petitioner for 1986 and

1987, respectively, were received and filed by the IRS on

April 16, 1992, and March 4, 1992.      Petitioner did not report

either the capital gain realized onthe stock sales during 1986

nor any of the interest and dividends received on the stock, bank

accounts, and certificates of deposit that were jointly in her

and Sandra's names.    However, sometime after filing her 1986 and

1987 returns (and presumably feeling the sting of the sizeable

levies by respondent), petitioner came forward and made known to

the IRS that she and not Sandra owned the stock sold during 1986,

and that petitioner also owned all of the various bank accounts

and certificates of deposit that were titled jointly with Sandra.

In the resulting audit of petitioner's 1986 and 1987 tax years,

respondent determined the gain realized from the stock sales and


record that petitioner
instituted an action against the IRS under sec. 7426 for the
return of wrongfully levied property.
                             - 17 -

that petitioner cannot be assessed and the levied funds cannot be

applied to satisfy the assessments.   Moreover, petitioner has not

executed any consent to an assessment and collection of the

amounts determined by respondent in the notice of deficiency for

1986 and 1987.

     As noted earlier, when petitioner filed her 1987 return, she

directed on the return that part of the $4,397 tax due should be

paid by application of $2,899.89 that respondent realized from a

levy on Crossland Savings, a bankthrough several levies.

     No reasons were stated in the notice of deficiency as to why

the $2,899.89 did not constitute a payment of the 1987 tax shown
                              - 18 -

on the return filed by petitioner, nor were any reasons stated by

respondent at trial to explain the action taken in disallowing

the $2,899.89 as a payment of the 1987 tax and subsequently

applying this amount to a 1989 tax liability of petitioner.

     Section 6151(a) provides generally that, when a return of

tax is required, the person required to make such return shall,

without assessment or notice and


of phrase - the surf struggles and collapses - pallid skeletal light. And the immediate, close nature of the wet panties - it's a touch - both mundane and brave - in the midst of the more abstract nature of the poem as a whole that stands out as physical and sexual - I really like it.

Posted 5 Years Ago

1 of 1 people found this review constructive.

I read you ... in my head I hear "Yup! a true LA Poet!" Why this is I cannot say. Nothing here is pretty or shimmers, or is sad or wistful, glittering or glamorous or even remotely pretty. Rather it is all raw and harsh and painful - but I am drawn to it all, and find myself loving it. Not afor heat stress response, the up-regulation of *ZmHsfA2* was expected. Subclass A2 were also induced by HS in rice and sorghum^[@CR45],[@CR46]^. The *ZmHsf05* of subclass A2 was induced by HS treatment in maize, and rescued the reduced thermotolerance of the *athsfa2* mutant in *Arabidopsis*. In *ZmHsf05*-overexpressing lines of *Arabidopsis*, the basal and acquired thermotolerance of plants were all enhanced^[@CR41]^. Up-regulations of the four ZmHsfs of subclass B2 were observed in maize after heat treatment, similar to the expression of both *SlyHsf03* and *SlyHsf10* of subclass B2 in tomato, which increased dramatically after heat treatment for 1--2 h^[@CR23]^. The *ZmHsf12* and *ZmHsf06* of subclass A1 were down-regulated in both anthesis and post-anthesis stages, differing from previous studies in maize seedlings^[@CR33]^~.~ The expression levels of *TaHsfA1a* was down-regulated after heat


into a small truncated AtHsfA2 protein at HS recovered stage. This "small AtHsfA2" protein was shown to bind to the TATA box-proximal clusters of HSE in the HsfA2 promoter to activate the transcription of *HsfA2*^[@CR59]^.

In our experiment, only *ZmHsf04* and *ZmHsf17* were found to have AS events after HS, in the form of intron retention. *ZmHsf04-II* and *ZmHsf17-II* retained different partial introns which containing several premature termination codons. The two truncated isoforms of *ZmHsf04* and *ZmHsf17* might be involved in different transcriptional regulation process. Based on the amino acid sequences, we speculated that *ZmHsf17-II* without the LRM may be degraded by NMD, like the *AtHsfA2-II of Arabidopsis*^[@CR58]^. However, *ZmHsf04-II* with the LRM in C-terminal could be translated and activate the transcription of *ZmHsf04-I*, like the *AtHsfA2-III* of *Arabidopsi*s^[@CR59]^.course, over the course of the season. That’s enough to circle the globe one and a half times. On the other side of the spectrum, Ball State likely won’t step foot in an airplane during their regular season, traveling a mere 1,692 miles all season. Let’s take a look at the difference. First here’s Hawaii’s flight plans, including starting the season in Fort Collins against Colorado State:

And now, Ball State’s short trips through the Midwest (which will largely be via bus rather than flying):

It’s clear to see the differences between the two, and the associated travel nightmare that the Rainbow Warriors tend to have to deal with annually. In fact, Hawaii will fly more than 50% farther than the second most-traveled school in the FBS this season. That


second team, Navy, spends most of their travel on an away game at, you guessed it, Hawaii itself. Before we continue on with more facts, let’s take a look at my assumptions.

Assumptions:

“Power Five” conference teams will fly for anything longer than around 300 miles or five hours drive.

Non-P5 teams will fly for anything longer than around 500 miles or eight hours drive.

Driving mileage is via Google Maps’ quickest route.

Flying mileage is via GCMap’s direct route between the most suitable airport nearest to campus to the nearest suitable airport for the opposing team.

Teams return home after every week, which I’m pretty sure happens as even Hawaii has two weeks between away games this season.

With that, there may be a few cases where a team is likely to fly belowm_{B})/0.05;$$ $$dh_{B}/dt = (1/(1 + exp( - 0.55(V + 43))) - h_{B})/1.5;$$

The spike-generating mechanism is described by TTX-sensitive sodium and TEA-sensitive potassium Hodgkin-Huxley type currents: $$I_{Na(TTX)} = g_{Na(TTX)}^{\ast}m^{3}h(V - V_{Na});$$ $$I_{K(TEA)} = g_{K(TEA)}^{\ast}n^{4}(V - V_{K});$$ $$dm/dt = (1/(1 + exp( - 0.4(V + 31))) - m)/0.0005;$$ $$dh/dt = (1/(1 + exp(0.25(V + 45))) - h)/0.01;$$ $$dn/dt = (1/(1 + exp( - 0.18(V + 25))) - n)/0.015;$$

The calcium transient voltage-dependent current is described by: $$I_{Ca} = g_{Ca}^{\ast}m_{Ca}^{2}(V - V_{Ca});$$ $$dm_{Ca}/dt = (1/(1 + exp( - 0.2V)) - m_{Ca})/0.01;$$

The calcium stationary \[*Ca*^2+^\]~*in*~ inhibited current is given by: $$\begin{array}{l}
{I_{Ca\mspace{2mu} - \mspace{2mu} Ca} = g_{Ca\mspace{2mu} - \mspace{2mu} Ca}^{\ast}\frac{1}{1 + exp( - 0.06(V + 45))}} \\
{\text{                           }\frac{1}{1 + exp(K_{\beta}(\lbrack Ca\rbrack - \beta))}(V - V_{Ca});} \\
\end{array}$$ $$d\lbrack Ca\rbrack/dt = \rho - I_{Ca}/2Fv - K_{s}\lbrack Ca\rbrack;$$


temporal asymmetry. Figure [2B](#F2){ref-type="fig"} illustrates two examples of regular and irregular spiking-bursting activity, respectively, for representative values of *g*~12~ and *g*~21~ conductances. One can see the asymmetric phases of the regular rhythm as compared to the one depicted in Figure [2A](#F2){ref-type="fig"}.

![**Map of conductances *g*~12~ and *g*~21~ of the temporal asymmetric mutually inhibitory circuit that lead to regularization of the spiking-bursting activity**. The incremental step for both *g*~12~ and *g*~21~ is 0.0025 μ*S*. Black circles represent values that lead to regular activity (*C*~*v*~ \< 5%). The map shows a reduced number of configurations of parameters that leads to regular activity as a consequence of the temporal asymmetry in the connection between the neurons. Parameters: *k*~1~ = 0.6 *ms*^−1^, *k*~2~ = 0.27 *ms*^−1^. Red squares correspond to specific values ofThis result hints that the gap-junction connectivity, with its associated dynamical inertia, could contribute to enlarge the regions of regular spiking-bursting activity in living half-center oscillators.

![**Map of conductances *g*~12~ and *g*~21~ of the circuits with gap-junction induced asymmetry that lead to regularization of the spiking-bursting activity where the incremental step for both *g*~12~ and *g*~21~ is 0.0025 μ*S***. Black circles represent values that lead to regular activity (*C*~*v*~ \< 5%). Parameters: *k*~1~ = 0.6 *ms*^−1^, *k*~2~ = 0.27 *ms*^−1^, $g_{23,32}^{gj}$ = 0.0045 μ*S*.](fncom-11-00009-g0008){#F8}

4. Closed-loop exploration for regular bursting rhythms {#s4}
=======================================================

In the previous sections we have presented a modeling study in minimal mutually inhibitory circuits of the asymmetry factors that contribute to shape regular and irregular spiking-bursting rhythms. How could the hypotheses drawn in this paper be tested experimentally?


Regular rhythms resulting from realistic asymmetric synaptic configurations display specific phase relationships that reflect the balance among the distinct sources of asymmetry.

Irregularity regimes are typically disregarded both in experimental and theoretical CPG research. One reason for this is that regular rhythms, as recorded in experimental setups, are more easily associated with observable rhythmic CPG motor functions. Several theoretical studies have shown that regular regimes could be more efficient for specific motor tasks (Huerta et al., [@B14], [@B15]; Stiesberg et al., [@B34]). However, coordinated irregularity is also present in living CPGs under normal and pathological circumstances and might mediate key aspects of the rhythm negotiation in these circuits. Recent brute force approaches to map the parameter space in half center oscillators models inspired by the leech heartbeat CPG havehaven't realize it by now,yeah, that's why I never even bothered to talk to u. I used to read in magazines,blogs etc etc that self confidence can change people attitude. I guess that explained why u've changed. But somehow u took all that confidence and changed it into something miserable. I know u are not satisfied with ur life. That's why u have been feeling all of that insecurities. I try to be there for u. Even I can't do much. I was always there to listen. But somehow u overlook all of that. Somehow in ur memories, I'm just a person u have come to met. Somehow our friendship means nothing. Somehow u have forget what we have been through. I can see that u are standing


Q:

How to know if form is submitted without errors in puppeteer

I am trying to submit a form and I am testing for cases where the form won't submit due to invalid input. If the zip code I enter is valid, then this line of code will return null because there was no error message.
await self.page.waitForFunction(
    'document.querySelector("#adr-zip-error")'
  );

However I have to hard code a delay before this or set some kind of timeout to catch this error message.
I tried also checking if the form itself is null in the same way but again, it only works if I check after some amount of time as it takes time for the form to submit.
Is there a way to tell if a form is submitted successfully withoutGenomic and transcriptomic characterisation of undifferentiated pleomorphic sarcoma of bone.
Undifferentiated pleomorphic sarcoma of bone (UPSb) is a rare primary bone sarcoma that lacks a specific line of differentiation. There is very little information about the genetic alterations leading to tumourigenesis or malignant transformation. Distinguishing between UPSb and other malignant bone sarcomas, including dedifferentiated chondrosarcoma and osteosarcoma, can be challenging due to overlapping features. To explore the genomic and transcriptomic landscape of UPSb tumours, whole-exome sequencing (WES) and RNA sequencing (RNA-Seq) were performed on UPSb tumours. All tumours lacked hotspot mutations in IDH1/2 132 or 172 codons, thereby excluding the diagnosis of dedifferentiated chondrosarcoma. Recurrent somatic mutations in TP53 were identified in four of 14 samples (29%). Moreover, recurrent mutations in histone chromatin remodelling genes, including H3F3A, ATRX and


the Area it Sought to Annex.

       II.     Whether the Chancellor Erred in Modifying Her Original
               Opinion to Allow the City of Jackson to Annex 220 Business
               Park.

                                   STANDARD OF REVIEW

¶5.    “This Court's standard of review for annexation is very limited.     The Court can only

reverse the chancery court's findings asexpansion. A
        major indicator of a city in decline is the low number of new residential
        subdivision lots platted. Only 34 residential purchases were made in northwest
        Jackson during the year 1998 and only 691 new residential lots were platted in
        the entire City of Jackson from January 1, 1990, until August 31, 2000. In the
        City of Ridgeland, the population is up, residential building permits are up,
        commercial building permits are up, and new streets are being constructed to


 accommodate internal growth.         Ridgeland housing units increased by 3,789
        while Jackson housing units decreased by 3,696. All indicators of growth reveal
        Ridgeland as the City growing internally.

¶10.    We hold the chancellor’s finding is correct, in that Ridgeland has a far greater need to

expand its territorial borders than the City of Jackson.           Therefore, we find this factor favors

annexation by Ridgeland.

        2. Path of growth

¶11.    A city need only show that the areas to be annexed are in its path of growth. The path

of                                                   8
¶14.     Both cities established that the areas to be annexed are in their path of growth. However,

the fact that Ridgeland has little area or direction in which to expand while Jackson has

substantially vacant areas in which to expand justifies the chancellor’s original finding that the

annexation area is in Ridgeland’s actual path of growth. We find this factor favors annexation

by Ridgeland.

         3. Potential health hazards

¶15.


Then-Jackson Police Chief Bracy Coleman testified that Jackson already

                                                    11
has a problem with the amount of crime in the city and that the police department is

understaffed. In 1998, for instance, Jackson was nationally ranked in the top ten of per capita

homicides.     All told, Jackson had already lost numerous residents and businesses because of

the high crime rate within the city.     Jackson’s budget of roughly $28 million would require a

dramatic increase         The Stokes-Mathew Road area in

north Ridgeland was annexed by Ridgeland in 1980, but did not obtain sewer service until

1998.    Moreover, the area had inadequate fire protection, as water lines were too small to

provide sufficient water flow service to the area.

                                                     13
¶31.    While both Jackson and Ridgeland have had inadequacies concerning the provision of

services to residents, Jackson’s are more sever.


bank, all that stuff because my parents were traveling ministers."

"And so, when I was 13, the church bought me a guitar," she continued.

"That's where I got that one from," Wilson said motioning to her guitar.

"Exactly, so I relate to what you are saying. I think it's so beautiful. And I think you know... it doesn't really matter where you come from," Perry told Wilson. "I know it's so hard, this struggle. And you're an inspiration to so many people by getting here today."

Richie also spoke up, telling Wilson she was here for a reason and a purpose.

"God can only do for you what he can do through you," he pointed out.

And it was then that all three judges told Wilson she was going to Hollywood for the nexttumors) [@Michor].

One of the most successful theoretical methods for studying genomic evolution at high mutation rates has been Eigen’s quasispecies model [@Eigen]. This model considers an explicit population of genomes, each made up of $L$ nucleotides chosen from an alphabet of size $S$, usually chosen to be two for simplicity or four to model the nucleotides in nature. These genomes replicate, mutate and compete on a chosen fitness landscape, a unique mapping of genotype to fitness. This is often accomplished by assigning different replication rates to each possible genome and setting all death rates to be equal. The model has yielded a number of impressive and experimentally verified predictions [@Crotty; @Kamp; @Kamp2; @Brumer1] and has recently been used as the basis for novel anti-viral therapies [@Crotty; @Loeb]. The


for the low semiconservative threshold (for example, the single fitness peak landscape yields 1.39 errors/genome/replication as an upper bound for the error threshold in a long semiconservative genome, while cancer cells display error rates over three orders of magnitude greater). Furthermore, the rapid replication rates that allow such high mutation rates in the conservative case provide no help, as the maximum allowed mutation rate cannot exceed a rather low threshold value, no matter how fast the cancer cells replicate. Hence, these recent results appear to present a paradox: rapidly mutating genomes are prevalent in cancerous cells, but such high mutation rates should exceed the error threshold and hence yield inviable genomes.

In this paper, we address this paradox and demonstrate that a semiconservative system can mimic a conservative populationcells have demonstrated down-regulation of DNA repair genes [@Tatjana]. All-[*trans*]{}-retinoic acid has been shown to prevent certain carcinogenic transformations by enhancing DNA repair through checkpoint effects [@Dragnev]. Lastly, numerous human studies have shown positive correlations between individual fluctuations in DNA repair capability and cancer risk [@Berwick].

Although it is clear that DNA repair is linked to tumor suppression, we are suggesting a fundamentally different outlook on the problem. Rather than simply protecting the genome from mutations, DNA repair also prevents the proliferation of genomes with high mutation rates. As methyl-directed mismatch repair begins to fail, the error threshold will soon be crossed, unless DNA repair begins to fail as well. The available experimental evidence shows a definite correlation between repair failure and cancer risk, but causation is not evident.