Low level deltamethrin resistance in ticks from cattle of Kerala, a south Indian state.
The deltamethrin resistance status in Rhipicephalus (Boophilus) annulatus and R. (B.) microplus ticks collected from cattle of five organized farms of Kerala, south India was evaluated. Resistance was characterized using biological (larval packet test), biochemical (esterase enzyme activity assay) and molecular tools (PCR amplification and sequencing of deltamethrin resistance-associated genes). Characterization of field isolates revealed level I resistance in ticks collected from four out of five farms. Elevated level of α/β esterase activity was not recorded in isolates showing level I resistance. Previously reported point mutations in the carboxyl esterase (G1120A) and sodium channel (T2134A and C190A) genes were not observed in any of the field isolates. The present study showed a low level (levellives,” Koch wrote in his op-ed, published online Wednesday night. “Countries with the freest trade have tended to not only be the wealthiest but also the most tolerant. Conversely, the restriction of trade — whether through tariffs, quotas or other means — has hurt the economy and pitted people against each other.”

Trump has long pushed a protectionist trade agenda that has put him at odds with the orthodoxy of his own party, which has typically been supportive of free trade policies. The president, who pulled the U.S. out of the Trans-Pacific Partnership trade deal upon taking office and has threatened to do the same with NAFTA, has argued that the U.S. has long allowed other nations to take advantage of it in international trade and that his policies,


4  (d) 9  (e) 2  (f) -0.4
d
What is the fourth smallest value in -2, 2, -21357.3, -3, -1/3?
-1/3
What is the second smallest value in 3/5, 1/2, -1, -0.2, 30790, 0.03?
-0.2
What is the sixth biggest value in 5, 4, 1/91, 0.2, 4/3, 8, 363?
0.2
Which is the seventh smallest value?  (a) -28  (b) 0  (c) 2/11  (d) -2  (e) 32  (f) 15  (g) 0.4
e
Which is the third smallest value?  (a) -315  (b) 7  (c) -23  (d) 1/6
d
What is the fourth smallest value in -7168, 1/3, 15, -0.5, -1/9, 263, -5?
-1/9
What is the third biggest value in 0.1, -5, -4/7, 5, -4/3, 3/67, 2?
0.1
Which is the third smallest value?  (a) -0.4  (b) -314  (c)369, 2, 3/17, -4?
-2/5
Which is the fourth biggest value?  (a) -4  (b) 1.1  (c) 0.24  (d) -2  (e) 4  (f) -6795/4
d
Which is the sixth biggest value?  (a) 1  (b) 0.5  (c) -36/11  (d) -1.1  (e) -3  (f) -4
f
Which is the smallest value?  (a) 1.2  (b) 15/8  (c) 4  (d) 240  (e) -2
e
What is the third smallest value in 208, -5.6, -0.06, -5, -1/8?
-1/8
Which is the smallest value?  (a) 5023/3152  (b) 0  (c) -2  (d) -3  (e) 5
d
What is the fourth smallest value in -3.1, 0.1, 0, -92, 4, -0.3, 0.3?
0
What is the fifth smallest value in -16339, -0.9, 0.2, 4/7, -76?
4/7
What is the fourth biggest value


Nicotine induces H9C2 cell apoptosis via Akt protein degradation.
Smoking is highly associated with cardiovascular diseases. However, the effect of nicotine, a key ingredient in smoking products, on cardiomyocyte apoptosis remains controversial. The present study aims to clarify the role of nicotine on cardiomyocyte cell apoptosis and to investigate the underlying mechanism. In the present study, H9C2 cells were exposed to nicotine at various concentrations (0, 10 and 100 µM) for 48 h. Cell Counting Kit‑8 and TUNEL assays were performed to assess cell viability and apoptosis, respectively, and reverse transcription‑quantitative polymerase chain reaction and western blot analysis were used to investigate the mRNA and protein expression. PYR‑41, a ubiquitin E1 inhibitor, was employed to investigate whether the ubiquitin‑proteasome system was involved in the downregulation of Akt. An Akt1Triflavin, an Arg-Gly-Asp-containing peptide, inhibits the adhesion of tumor cells to matrix proteins via binding to multiple integrin receptors expressed on human hepatoma cells.
Integrins are a superfamily of cell surface glycoproteins that promote cellular adhesion. The interaction of integrins with extracellular matrices such as fibronectin and vitronectin has been shown to be mediated through an arginine-glycine-aspartic acid (RGD) sequence within adhesive proteins. Triflavin, a 7.5-kDa cysteine-rich polypeptide purified from Trimeresurus flavoviridis snake venom, belongs to a family of RGD-containing peptides, termed disintegrins. Disintegrins have been isolated from the venom of various vipers and have been shown to be potent inhibitors of platelet aggregation. In this study, we found that human hepatoma cell adhesion to immobilized matrix proteins (i.e. fibronectin, collagen, laminin, and vitronectin) was differentially affected by various


Jobless claims point to healing in labor market

A job seeker (R) meets with a prospective employer at a career fair in New York City, October 24, 2012.

Reuters/Mike Segar

WASHINGTON (Reuters) - The number of Americans filing new claims for jobless benefits fell last week and a trend reading hit a near five-year low, signs a grinding recovery in the labor market remains on track.

Other reports on Thursday showed many top U.S. retailers had strong sales in January even as customers were hit with higher taxes, while productivity at businesses slumped in the fourth quarter.

Initial claims for state unemployment benefits dropped by 5,000 to a seasonally adjusted 366,000, the Labor Department said. That was enough to pull down a four-week moving average of new claims, a gauge of the trendon events in Europe. U.S. stock prices and yields on U.S. government debt fell on worries about the economic outlook in Europe, which were fanned by European Central Bank President Mario Draghi's comments that policymakers are monitoring the economic impact of a stronger euro.

PRODUCTIVITY SLUMPS

The U.S. economy has shown signs of underlying strength despite a surprise contraction in the fourth quarter.

Consumer spending has looked more robust, and many U.S. retailers on Thursday reported strong sales in January.

Overall, same-store sales rose 5 percent in January across 20 retailers, according to Thomson Reuters I/B/E/S, pointing to some resilience in spending despite a hike in payroll taxes that hit most Americans last month.

The Commerce Department's more comprehensive report on January retail sales, due on February 13, is expected to show sales


78-91%) across 13 studies individually utilizing imaging data within their own institutions compared to radical prostatectomy specimens \[[@R19]\]. This is in agreement with other studies conducted at a single center but with multiple readers \[[@R6], [@R20]\]. In our study, we found an index lesion sensitivity for PI-RADSv2 ≥ 3 of 78%. PI-RADSv2's intended aim is to broadly standardize interpretation; our findings largely support this aim.

A known weakness of mpMRI is the TZ where sensitivity is particularly low. The TZ is difficult because of its complex, variable architecture where features of cancer overlap with prostatic hyperplasia \[[@R21], [@R22]\]. Interestingly, for lesions scored PI-RADSv2 ≥1, the greatest CAD benefit was seen in the TZ where it helped moderately experienced readers to achieve 83.8% sensitivity with CAD versus 66.9% with mpMRI.trials that are often first reported in academic settings. Finally, the training population utilized for our CAD system was relatively limited in an effort to prevent overlap with the study population. It has previously been shown that CAD sensitivity can be increased with a larger fraction of difficult cases included in the training database \[[@R35]\]. A focus on further diversifying the training population might improve the results of CAD validation.

In conclusion, when using PI-RADSv2 and a CAD system based on heterogeneous imaging acquisitions, readers with different experience levels were able to detect index lesions with comparable sensitivity to non-assisted interpretations. The addition of CAD improved reader specificity and provided a time efficiency advantage. In order to be robust, CAD systems must be based on diverse data sets and


coil information, and MRI acquisition parameters utilized in this study. For subsequent CAD processing, a high *b-*value image of b=1500 mm/sec^2^ was needed, and so in cases where this was not available, the high b value image was calculated utilizing the mono-exponential model \[[@R36]\].

Image de-identification {#s4_4}
-----------------------

To comply with the Office of Human Subjects Resources guidelines for utilization of external data, all images had to be completely de-identified at their respective original institutions prior to collection to ensure patient confidentiality. This de-identification was performed using standard scripts removing patient information as well as clearing DICOM tags other than those reflecting scanner parameters. Upon our collection of the data, an additional de-identification script was used to immediately process the images for a second time to guarantee patient privacy.

Radiologist profile {#s4_5}
-------------------

NineDoris Duke Charitable Foundation, The American Association for Dental Research, the Colgate-Palmolive Company, Genentech and alumni of student research programs and other individual supporters via contributions to the Foundation for the National Institutes of Health.

**CONFLICTS OF INTEREST**

Dr. Ronald M. Summers: Patent royalties from iCAD & ScanMed, Research support from Ping An & NVidia, Software licenses to Philips & Ping An.

Dr. Bradford J. Wood reports grants from NIH Intramural Research Program , during the conduct of the study; grants and non-financial support from CRADA with Philips, grants and non-financial support from CRADA with Celsion Corp, grants and non-financial support from CRADA with Siemens, grants and non-financial support from CRADA with Biocompatibles BTG, grants and non-financial support from CRADA with NVIDIA, grants and non-financial support from CRADA with Profound Medical,


of sofosbuvir-velpatasvir. The most common adverse events were fatigue (29%), nausea (23%), and headache (22%) in all patients and anemia (31%) in the patients receiving ribavirin. Treatment with sofosbuvir-velpatasvir with or without ribavirin for 12 weeks and with sofosbuvir-velpatasvir for 24 weeks resulted in high rates of sustained virologic response in patients with HCV infection and decompensated cirrhosis. (Funded by Gilead Sciences; ASTRAL-4 ClinicalTrials.gov number, NCT02201901.).It has wide views over fields and its own large raised deck where you can sit and eat or drink wine while watching the cows and sheep go by. It has a large shower and a well-equipped kitchen (including fridge, cooker, oven, toaster, kettle and selection of hot drinks) where you can make your own meals. There is a dining area and an office corner.
Our house and the flat get all their heat and hot water from a biomass boiler that burns local logs, which we happily explain to you if you would like to know about it. We are rather fond of our boiler!

The flat is surrounded by green Devon fields and working farms. It is very gentle and quiet, however our neighbours are dairy farmers and


office, hairdressers and an Indian restaurant. There are plenty of walks and cycle paths in the vicinity. The lovely East Devon coastline is only 20 minutes away. Dartmoor and Exmoor are also easily accessible.

We stay at Tina appartem on weekend...everithing was higts standard.We love everything.Tina and her husband is very friendly-nice people.We love come back ,easily recommended.

Vila2017-08-20T00:00:00Z

A perfect place for a stay in Exeter! My partner and I stayed for one night when attending a friend's wedding. The host Tina was extremely quick in responding to emails and was so accommodating to our needs during our short stay! The apartment itself is beautiful, with stunning views of the local countryside. It has everything you could need even for a much longer stay, including some much appreciated bacon andshop open from 8 am to 7 pm. all with food. Exeter 20 minutes, 40 minutes to the sea, Dartmoor is half an hour. Numerous National Trust properties. Cornwall easily visitable in a day.

A very convenient location, wonderful owners, clearly well loved by previous occupants.

Fleur2016-10-18T00:00:00Z

thorverton village is lovely, not within walking distance though. Desiree was charming, very helpful, bread butter and milk in the fridge waiting for us.

monica2016-09-05T00:00:00Z

A homely cottage experience with beautiful north Devon country view and a friendly and attentive host.

Adrien and Kirsty2016-05-08T00:00:00Z

This was the most wonderful little cottage. From the moment we booked Desiree was very helpful and made our stay feel like a home away from home. The area is not too far from Exeter if you want the hustle and bustle of a


put some out for us (we couldn't find anywhere that said they were or weren't included so maybe it was wrong of us to presume). Other than that, a lovely little property that was perfect for our short stay while we went to a friend's wedding at nearby Escot House. Thank you very much!

Julia2016-07-25T00:00:00Z

Everything you could want from a spotlessly clean place to stay in the countryside. Great hosts with helpful recommendations for takeaways that would deliver and also providing us with an OS map of the area which was very useful. You are guaranteed a silent night's sleep, a very good shower, and all the kit you could need in the kitchen. There was the thoughtful touch too of a welcome basket of goodies!

Laurie2017-08-21T00:00:00Z

Really enjoyed our stayClose to town, Tesco is a 5minute walk and the canal is across the road. Thank you Shiela!!

Emma 2016-10-23T00:00:00Z

Another pleasant stay at the apartment. Thanks again.

Richard2016-04-28T00:00:00Z

What a fantastic place to stay! The flat was lovely and Sheila had left us some bread and milk which was really kind. The flat was completely self-contained and had all the amenities you would need for a stay and was beautifully decorated, a real home from home. We'll definitely be back again!

Ruth2016-11-11T00:00:00Z

Just as lovely as last time.

Stephanie2017-01-25T00:00:00Z

Lovely accommodation with thoughtful provision of groceries to set you up after the journey and during the visit.

Stephanie2017-05-17T00:00:00Z

Tipo de quarto

Casa inteira/apto

Tipo de Imóvel

Apartamento

Acomoda

2

Quartos

Alford Pasture is situated on the eastern-side of the developing town of Cranbrook, Devon. Located north-west of the village of Rockbeare, between the B3174


was spacious with a good shower. Good small kitchen and everything was there that I needed. A bit of a walk to town but saying that there are frequent busses that pass very close to the apartment. Pretty quiet neighbourhood as in a cul de sac,, a big Sainsbury is an easy 15mins walk away but a co-op, green grocer and bakery was even closer,, great value and very comfortable,,,,

Lisa Jody2015-07-31T00:00:00Z

Emma was such a welcoming host but also happy to leave me to do my own thing. It was great to be able to use the kitchen and Emma gave me a large cupboard and plenty of room in the fridge. The location is great for anyone visiting the Met Office (only a 20 minute walk) and Iand short run releases, which brings us nicely back to Exit Condition.

Now, while I would argue that the gig and ‘zine network created at the time unwittingly helped lay the foundations for the ‘alternative rock’ and indie boom that followed, I’d find it more difficult to argue that many really great records came out of this period (1984 or ‘85, up to the point where things changed once again with the success of Nirvana’s ‘Nevermind’) Some did though and one album that really does stand up is Exit Condition’s ‘Days Of Wild Skies’ from 1990. I picked up my copy from Ian who ran the label that released this, Meantime Records, when my band at the time Wordbug were playing a festival at Bradford’s 1 In 12 Club.


  XX   He prepares a Stratagem, but finds himself countermined--
             Proceeds on his Journey, and is overtaken by a terrible
             Tempest
     XXI   He falls upon Scylla, seeking to avoid Charybdis.
    XXII   He arrives at Paris, and is pleased with his Reception
   XXIII   Acquits himself with Address in a Nocturnal Riot
    XXIV   He overlooks the Advances of his Friends, and smarts severely
             for his Neglect
     XXVcircumstances of their birth, and are consecrated from the cradle for
the purposes of greatness, merely because they are the accidental
children of wealth.  He was heir to no visible patrimony, unless we
reckon a robust constitution, a tolerable appearance, and an uncommon
capacity, as the advantages of inheritance.  If the comparison obtains in
this point of consideration, he was as much as any man indebted to his
parent; and pity it was, that, in the sequel of his fortune, he never had
an opportunity of manifesting his filial gratitude and regard.  From this
agreeable act of duty to his sire, and all those tendernesses that are
reciprocally enjoyed betwixt the father and the son, he was unhappily
excluded by a small circumstance; at which, however, he was never heard
to repine.  In short, had


to whom they belonged, the schoolmaster chanced
to peruse the version of Ferdinand, before he looked into any of the
rest, and could not help bestowing upon it particular marks of
approbation.  The next that fell under his examination was that of the
young Count, when he immediately perceived the sameness, and, far from
imputing it to the true cause, upbraided him with having copied the
exercise of our adventurer, and insisted upon chastising him upon the
spot for his want of application.

Had not the young gentleman thought his honour was concerned, he would
have submitted to the punishment without murmuring; but he inherited,
from his parents, the pride of two fierce nations, and, being overwhelmed
with reproaches for that which he imagined ought to have redounded to his
glory, he could not brook the indignity, and boldlyconversation, tending to inspire her with the
love of guilty pleasure, to debauch her sentiments, and confound her
ideas of dignity and virtue.  After all, the task is not difficult to
lead the unpractised heart astray, by dint of those opportunities her
seducer possessed.  The seeds of insinuation seasonably sown upon the
warm luxuriant soil of youth, could hardly fail of shooting up into such
intemperate desires as he wanted to produce, especially when cultured and
cherished in her unguarded hours, by that stimulating discourse which
familiarity admits, and the looser passions, ingrafted in every breast,
are apt to relish and excuse.

Fathom had previously reconnoitred the ground, and discovered some marks
of inflammability in Mademoiselle's constitution; her beauty was not such
as to engage her in those gaieties of amusement which could flatter her
vanity and dissipate her


on the wane.  She
very graciously consoled our gallant for the mishap of which he
complained, representing Wilhelmina (that was the daughter's name) as a
pert, illiterate, envious baggage, of whose disgust he ought to make no
consideration; then she recounted many instances of her own generosity to
that young lady, with the returns of malice and ingratitude she had made;
and, lastly, enumerated all the imperfections of her person, education,
and behaviour; that he might see with what justice the gypsy pretended to
vie with those who had been distinguished by the approbation and even
gallantry of the best people in Vienna.

Having thus established himself her confidant and gossip, he knew his
next step of promotion would necessarily be to the degree of her lover;
and in that belief resolved to play the same game with Mademoiselle
Wilhelmina,of the supposed thief, started up from his chair, swearing by
G--'s mother that he would forthwith arm himself with a brace of pistols,
and search every apartment in the house.  "That press," said he, with
great vociferation, "may, for aught I know, be the receptacle of some
ruffian."

So saying, he approached the ark in which Fathom was embarked, and
exclaiming, "Come forth, Satan," applied his foot to the door of it, with
such violence as threw him from the centre of gravity, and laid him
sprawling on his back.  This address made such an impression upon our
adventurer, that he had well-nigh obeyed the summons, and burst from his
concealment, in a desperate effort to escape, without being recognised by
the intoxicated German; and indeed, had the application been repeated, he
in all likelihood would have


accurate survey of every object in the apartment,
and, in the course of his inquiry, had the mortification to find the dead
body of a man, still warm, who had been lately stabbed, and concealed
beneath several bundles of straw.

Such a discovery could not fail to fill the breast of our hero with
unspeakable horror; for he concluded that he himself would undergo the
same fate before morning, without the interposition of a miracle in his
favour.  In the first transports of his dread, he ran to the window, with
a view to escape by that outlet, and found his flight effectually
obstructed by divers strong bars of iron.  Then his heart began to
palpitate, his hair to bristle up, and his knees to totter; his thoughts
teemed with presages of death and destruction; his consciencethis fatal overthrow must be in despair
upon my account."

So saying, he presented a letter, directed to his lady, which I received
in a transport of joy, with expressions suitable to the occasion, and
immediately set out for his country house, which happened to be about
thirty leagues from the spot.  This expedition was equally glorious and
interesting; for my thoughts upon the road were engrossed by the hope of
seeing Don Orgullo's daughter and heiress Antonia, who was reported to be
a young lady of great beauty, and the most amiable accomplishments.
However ridiculous it may seem for a man to conceive a passion for an
object which he hath never beheld, certain it is, my sentiments were so
much prepossessed by the fame of her qualifications, that I must have
fallen a victim to her charms,


value of a thousand crowns, and desiring him to detain for
his own use any part of the sum they would raise.  Our adventurer thanked
him for the good opinion he entertained of his integrity, an opinion
fully manifested in honouring him with such important confidence, and
assured him he would transact his affairs with the utmost diligence,
caution, and despatch.  The evening being by this time almost consumed,
these new allies retired separately to rest; though each passed the night
without repose, in very different reflections, the Castilian being, as
usual, agitated with the unceasing pangs of his unalterable misery,
interspersed with gleaming hopes of revenge; and Fathom being kept awake
with revolving plans for turning his fellow-lodger's credulity to his own
advantage.  From the nature of the Spaniard's situation, he might have
appropriated the jewelswhole strength of his accomplishments at
once, but contrived to spring a new mine of qualification every day, to
the surprise and admiration of all his acquaintance.  He was gifted with
a sort of elocution, much more specious than solid, and spoke on every
subject that occurred in conversation with that familiarity and ease,
which, one would think, could only be acquired by long study and
application.  This plausibility and confidence are faculties really
inherited from nature, and effectually serve the possessor, in lieu of
that learning which is not to be obtained without infinite toil and
perseverance.  The most superficial tincture of the arts and sciences in
such a juggler, is sufficient to dazzle the understanding of half
mankind; and, if managed with circumspection, will enable him even to
spend his life among the literati, without


THAT CONVEYS A TRUE IDEA OF HIS GRATITUDE
AND HONOUR.

It was not long after this celebrated victory, that he was invited to
spend part of the summer at the house of a country gentleman, who lived
about one hundred miles from London, possessed of a very opulent fortune,
the greatest part of which was expended in acts of old English
hospitality.  He had met with our hero by accident at the table of a
certain great man, and was so struck with his manner and conversation, as
to desire his acquaintance, and cultivate his friendship; and he thought
himself extremely happy in having prevailed upon him to pass a few weeks
in his family.

Fathom, among his other observations, perceived that there was a domestic
uneasiness, occasioned by a very beautiful young creature about the age
of fifteen, whoand, with that view, whenever
she complained of the vapours or dejection, he prescribed, and even
insisted upon her swallowing certain cordials of the most palatable
composition, without which he never travelled; and these produced such
agreeable reveries and flow of spirits, that she gradually became
enamoured of intoxication; while he encouraged the pernicious passion, by
expressing the most extravagant applause and admiration at the wild
irregular sallies it produced.  Without having first made this diversion,
he would have found it impracticable to leave the house with
tranquillity; but, when this bewitching philtre grew into an habit, her
attachment to Ferdinand was insensibly dissolved; she began to bear his
neglect with indifference, and, sequestering herself from the rest of the
family, used to solicit this new ally for consolation.

Having thus put the finishing stroke to the daughter's ruin, he


assistance
from their forefathers.  One, she said, sprung from the loins of an
obscure attorney; another was the grandson of a valet-de-chambre; a third
was the issue of an accountant; and a fourth the offspring of a
woollen draper.  All these were the children of their own good works, and
had raised themselves upon their personal virtues and address; a
foundation certainly more solid and honourable than a vague inheritance
derived from ancestors, in whose deserts they could not be supposed to
have borne the least share.

Monimia listened to all these arguments with great patience and
affability, though she at once dived into the source from which all such
insinuations flowed.  She joined in the commendations of Fathom, and
owned herself a particular instance of that benevolence which the old
lady had so justly extolled; but, onceto receive his salutation, at their very next
meeting in the thoroughfare, returned his bow with marks of profound
respect.  Nay, at midnight, she, with the rest, took post in the same
place where they had been stationed before; and, by frequent tittering,
and repeated whispers, gave intimation to Fathom, that they would be glad
of a second serenade.  But he was too well acquainted with the human
passions to indulge this their desire.  It was his interest to inflame
their impatience, rather than to gratify their expectation; and therefore
he tantalised them for some hours, by tuning his violin, and playing some
flourishes, which, however, produced nothing to fulfil their wishes.

At the ordinary, he was accosted by a gentleman, a lodger in the same
house, who assured him, that the ladies would take it


name was
occasionally put to the torture, with that of the vile creature whom he
had seduced, though it was generally taken for granted by all those
female casuists, that she must have made the first advances, for it could
not be supposed that any man would take much trouble in laying schemes
for the ruin of a person whose attractions were so slender, especially
considering the ill state of her health, a circumstance that seldom adds
to a woman's beauty or good-humour; besides, she was always a pert minx,
that affected singularity, and a masculine manner of speaking, and many
of them had foreseen that she would, some time or other, bring herself
into such a premunire.  At all gossipings, where the apothecary or his
wife assisted, Fathom's pride, ingratitude, and malpractice were
canvassed; in all clubs ofmarried men he was mentioned with marks of
abhorrence and detestation, and every medical coffee-house rung with his
reproach.  Instances of his ignorance and presumption were quoted, and
many particulars feigned for the purpose of defamation, so that our hero
was exactly in the situation of a horseman, who, in riding at full speed
for the plate, is thrown from the saddle in the middle of the race, and
left without sense or motion upon the plain.

His progress, though rapid, had been so short, that he could not be
supposed to have laid up store against such a day of trouble, and as he
still cherished hopes of surmounting those obstacles which had so
suddenly started up in his way, he would not resign his equipage nor
retrench his expenses, but appeared as usual in all public


knew had long looked upon him in the odious light of
an interloping rival.  However, he reaped no benefit from this
supplication, which served only to gratify the pride of Buffalo, who
produced the extravagant encomiums which Fathom had bestowed upon him, as
so many testimonials of his foe's bearing witness to his virtue.

CHAPTER FIFTY-SEVEN

FATHOM BEING SAFELY HOUSED, THE READER IS ENTERTAINED WITH A RETROSPECT.

But now it is high time to leave our adventurer to chew the cud of
reflection and remorse in this solitary mansion, that we may trace
Renaldo in the several steps he took to assert his right, and do justice
to his family.  Never man indulged a more melancholy train of ideas than
that which accompanied him in his journey to the Imperial court.  For,
notwithstanding the manifold reasons hewhich will in a little time restore your family to the
fruition of its rights and fortune.  For my own part, my dear Count, I
consider myself as one wholly indebted to your house for the rank and
expectation I now enjoy; and my finances, interest, and person, such as
they are, I dedicate to your service."

Renaldo was not slow in making his acknowledgments to this generous
Hibernian, whom he informed of his scheme, recounting to him his uncommon
transaction with the benevolent Jew, and communicating the letters of
recommendation he had received by his means to some of the first noblemen
at the Imperial court.  Meanwhile, he burned with impatience to chastise
Count Trebasi for his perfidious conduct to the widow and the fatherless,
and would have taken the road to Presburg, without touching at


his way to the Austrian Netherlands,
and arrived at the fortress of Luxemburg, where he was obliged to tarry a
whole day on account of an accident which had happened to his chaise.
Here he went to view the fortifications; and as he walked along the
ramparts, his ears were saluted with these words: "Heaven bless the noble
Count de Melvil! will not he turn the eyes of compassion on an old
fellow-soldier reduced to misfortune and disgrace?"

Surprised at this address, which was attended with the clanking of
chains, Renaldo lifted up his eyes, and perceived the person who spoke
to be one of two malefactors shackled together, who had been sentenced
for some crime to work as labourers on the fortifications.  His face was
so covered with hair, and his whole appearance so disguised by the
squalidi have that they wont overspend and get in a mess again.
I dont know if the wife worked sooner and they hired help if that could help them and if they would consider that.
why should i give my bit of money, i'm not a rich person, when in various ways they or their partner overspends instead of really taking their debt seriously and really doing everything to gt out of it and to lower expenses and to cut out all expenses
I know rich people who buy everything second hand to build themselves up.
I do know people who need to save who just have certain standards in clothes etc and you will never change them but hopefully they can anyway save despite their higher standards of spending in some


ways

whats worse is they dont stay calm when i try to talk to them and why would anyone help someone who gets angry. noone has to help them. if someone is trying to talk to them, they better treat them calmly and nicely respectfully as it may lead to some help but it wont if they bit you and show anger and make it very stressful

i under stand its a stressful topic, but if i remind them of stress to talk about it, it may lead to something, they need to be able to answer calmly and then try to switch off. I understand that is tough but biting someone or refusing to answer wont lead to any help.

what are signs or questions i could ask or expectationsthemselves up.
I do know people who need to save who just have certain standards in clothes etc and you will never change them but hopefully they can anyway save despite their higher standards of spending in some ways

whats worse is they dont stay calm when i try to talk to them and why would anyone help someone who gets angry. noone has to help them. if someone is trying to talk to them, they better treat them calmly and nicely respectfully as it may lead to some help but it wont if they bit you and show anger and make it very stressful

i under stand its a stressful topic, but if i remind them of stress to talk about it, it may lead to something, they need to


One-step synthesis of amino-functionalized fluorescent carbon nanoparticles by hydrothermal carbonization of chitosan.
Highly amino-functionalized fluorescent carbon nanoparticles (CNPs) were fabricated by hydrothermal carbonization of chitosan at a mild temperature. They were applied to bioimaging of human lung adenocarcinoma A549 cells, showing low cytotoxicity and excellent biocompatibility.$\delta$, combined with the fact that a $p$-form is harmonic if and only if it is closed and coclosed. No analysis is needed here. However, this only gives the inclusion $$\delta(E^{p+1}(M))\oplus d(E^{p-1}(M))\subset\left(\mathcal{H}^p(M)\right)^\perp.$$ But the first line of the theorem (which is, more or less, the crucial one) reads $$\Delta(E^p(M))=\left(\mathcal{H}^p(M)\right)^\perp,$$ which provides the inclusion you want.


controlled the size and distribution of macropores; micropores were created by polymethylmethacrylate (PMMA) microsphere porogens (1-30-microm pore diameter) and controlled sintering (pores <1 microm). Percent weight loss of the scaffolds and calcium and phosphorus ion concentrations in solution increased as the degradation period increased for all scaffold types. After degradation, compressive strength and compressive modulus decreased significantly for those scaffolds with microporosity. For scaffolds without microporosity, the changes in strength and modulus after degradation were not statistically significant. The compressive strength of scaffolds without microporosity was significantly greater than the scaffolds with microporosity.     requirements which act as the functional equivalent of a prior restraint on political speech. Plaintiff

                                     further challenges the constitutionality of the FEC's interpretation and enforcement process

                                     regarding political committee status, solicitation tests, the "major purpose" test, and express


                                                                                2
a motion to dismiss Plaintiffs claims pursuant to Fed. R. Civ. P. 12(b)(6). This motion has been

fully briefed and is ripe for a decision on the merits.

        "Ordinarily an interlocutory injunction appeal under 1292(a)(1) does not defeat the power

of the triala specific candidate." WRTL, 551 U.S. at 460-470

(emphasis added). This functional equivalent test closely correlates to the test set forth in subsection

(b), which provides that a communication is express advocacy if it "could only be interpreted by a

reasonable person as containing advocacy of the election or defeat of one or more clearly identified

                                                   8
candidate(s)." 11 C.F.R. § 100.22(b). Indeed, as the Fourth Circuit has noted, although the language

ofSection 110.22(b) does not exactly mirror WRTL's functional equivalent test, the


then applying the same burden to ads that go further

and are the functional equivalent of express advocacy cannot automatically be impermissible."

                                                  9
RTAA, 681 F.3d at 551-52 (emphasis original). As a result, Citizens United directly contradicts

Plaintiffs argument that the definition of express advocacy set forth in subsection (b) is overly broad

with respect to disclosure requirements.

       In addition to its overbreadth argument, Plaintiff urges that section 100.22(b) is

impermissibly vague based on the fact that thealso challenges the constitutionality of the "solicitation" standard used by the FEC

as vague and overbroad, arguing that it lacks clarity and guidance sufficient to enable interested

persons to tailor their activities in compliance with the law. The FECA defines "contribution" to

include "any gift, subscription, loan, advance, or deposit of money or anything of value made by any

person for the purpose of influencing any election for Federal office." 2 U.S.C. § 431 (8)(A)(i). It

further requires "any person" who "solicits any contribution through any broadcasting station,

newspaper, magazine, outdoor advertising facility, mailing, or any other type of general public

political advertising" to include a specified disclaimer in the solicitation. !d. § 441d(a); see 11


more than $1,000 in political expenditures or receives more than

$1,000 in contributions during a calendar year.        2 U.S.C. § 431 (4)(A). "Expenditures" and

                                                 12
"contributions" are defined to encompass any spending or fundraising "for the purpose of influencing

any election for Federal office." 2 U.S.C. §§ 431(8)(A)(i), 431(9)(A)(i). However, in Buckley v.

Valeo, the Supreme Court concluded that defining political committees only in terms of expenditures

and contributions "could be interpreted to reach groups engaged purely insuch as alkyd resins, are also useful as polyols for coating compositions. These resins are produced as products of an esterification reaction involving a polyhydric alcohol, i.e., a polyol such as glycerol, sorbitol, ethylene glycol or pentaerythritol, and a monobasic fatty acid, most of which are derived from natural drying and nondrying oils, such as linseed oil, soybean oil and castor oil, to form resin-based coating compositions having acceptable properties for certain applications. The resin may then optionally be further modified by the addition of a polybasic acid composition.
The reaction of hydroxyl groups with isocyanates to form urethanes is very well known. A large number of polyols and a large number of polyisocyanates are available to form polyurethane compositions useful as adhesives, potting compounds and coatings. However, due


other bigger names. — Jordan Reid (@JReidNFL) February 21, 2020

Mims is a contested catch highlight reel pic.twitter.com/Yop2FtEgdi — Jon Ledyard (@LedyardNFLDraft) January 23, 2020

Hamler has worst drop rate, but problem with Mims is that he lets so many CBs bully him at catch point at times, I’m not sure how many go down as drops but they are missed opportunities. https://t.co/BBuwpoQDj3 — Jon Ledyard (@LedyardNFLDraft) April 4, 2020

Walking out of Lucas Oil, a few quick thoughts:

- QB3 battle (Herbert/Love) still alive and well

- WR Justin Jefferson had the best night

- However high you have WR Denzel Mims, it’s probably not high enough

- Lamb still WR1

Writing a full recap tonight. #NFLCombine — Dane Brugler (@dpbrugler) February 28, 2020

Writing #NFLDraft400 profiles for the wide receivers and compared Denzel Mims toCourtland Sutton — Evan Silva (@evansilva) March 12, 2020

Chase Claypool, Wide Receiver, Notre Dame

The senior Fighting Irish wideout caught a team-high 66 receptions for 1,037 receiving yards (15.7 ypr. avg.) and 13 touchdown receptions in 13 starts.

Like the others in this piece, Claypool was a strong performer at the Senior Bowl—including a touchdown reception in the actual game.

At 6’4”, 238 pounds, the former basketball standout is an absolute ‘athletic freak’, as he recorded a 4.42 forty time, vertical jump of 40.5 inches, and a broad jump of 126.0 inches at the NFL Combine.

Those measurements helped him achieve a SPARQ rating of ~98% NFL percentile (third best in his entire wide receiver draft class).

Simply put, Claypool’s measurables are ‘out of this world’:

#NotreDame receiver, Chase Claypool, tested at the 80th


         SmallPtrSet<const Node *, 16> &Nodes) {
  for (const auto &Match : Matches)
    Nodes.insert(Match.getNodeAs<Node>(ID));
}

} // namespace

// Finds all DeclRefExprs where a const method is called on VarDecl or VarDecl
// is the a const reference or value argument to a CallExpr or CXXConstructExpr.
SmallPtrSet<const DeclRefExpr *, 16>
constReferenceDeclRefExprs(const VarDecl &VarDecl, const Stmt &Stmt,
                           ASTContext &Context) {
  auto DeclRefToVar =
      declRefExpr(to(varDecl(equalsNode(&VarDecl)))).bind("declRef");
  auto ConstMethodCallee = callee(cxxMethodDecl(isConst()));
  // Match method call expressions where the variable is referenced as the this
  // implicit object argument and opertor callexpression for member operators
  // where the variable is the 0-th argument.
  auto Matches = match(
      findAll(expr(anyOf(cxxMemberCallExpr(ConstMethodCallee, on(DeclRefToVar)),
                         cxxOperatorCallExpr(ConstMethodCallee,
                                             hasArgument(0, DeclRefToVar))))),
      Stmt, Context);
  SmallPtrSet<const DeclRefExpr *, 16> DeclRefs;
  extractNodesByIdTo(Matches, "declRef", DeclRefs);
  auto ConstReferenceOrValue =
      qualType(anyOf(referenceType(pointee(qualType(isConstQualified()))),


by post-MI PMR. Clinical data, echocardiographic data, catheterization data, and surgical data were stored in a dedicated database. Baseline patient characteristics are summarized in Table [1](#Tab1){ref-type="table"}. All patients had a documented MI before PMR. Infarct location was determined electrocardiographically and echocardiographically (by the detection of wall motion abnormalities). Four patients (8%) had a history of congestive heart failure, 12 patients (24%) had hypertension, 9 patients (18%) had diabetes mellitus, 16 patients (32%) were smokers, 6 patients (12%) had hypercholesterolemia, 7 patients (14%) were obese (body mass index \> 30 kg/m^2^), 2 patients (4%) had peripheral vascular disease, 7 patients (14%) had a family history of coronary artery disease, 1 patient (2%) had chronic renal disease, 3 patients (6%) had chronic obstructive pulmonary disease, and 5 patients (10%) had cerebrovascular disease.Table 1**Preoperative patientdata (n = 50)**Variable^a^ValueAge, years64.7 ± 10.8Gender Male36 (72) Female14 (28)NYHA functional class Class III7 (14) Class IV43 (86)EuroSCORE I (logistic), %29.9 ± 22.6EuroSCORE II, %19.6 ± 14.5Previous myocardial infarction50 (100) Inferior and/or posterior34 (68) Inferoposterolateral13 (26) Anterolateral9 (18)Coronary artery disease50 (100) Left main stenosis3 (6)  One-vessel disease24 (48)  Two-vessel disease18 (36)  Three-vessel disease8 (16)Infarct related artery Left anterior descending coronary artery1 (2) Left circumflex coronary artery29 (58) Right coronary artery20 (40)Previous percutaneous coronary intervention14 (28)Previous cardiac surgery0 (0)Preoperative grade of mitral regurgitation 3+ (moderate)1 (2) 4+ (severe)49 (98)Preoperative LV function Normal(EF \>50%)34 (68) Moderately impaired(EF 30-50%)11 (22) Severely impaired(EF \<30%)5 (10)Heart rhythm Sinus rhythm45 (90) Atrial fibrillation5 (10) Pacemaker0 (0)Pulmonary artery pressure Systolic/diastolic, mmHg45 ± 13/25 ± 10 Mean, mmHg32 ± 10Pulmonary capillary wedge pressure, mmHg24 ± 14Mechanical ventilation23 (46)Inotropic drug support28 (56)Intra-aortic balloon pump23 (46)Serum creatinine, μmol/L159 ± 94Acute renal failure10 (20)Cardiogenic shock33 (66)^a^Data are presented as mean ± standard deviation or number (%).EF = ejection fraction; LV = left ventricle; NYHA = New York Heart Association.

Echocardiography and coronary angiography {#Sec4}
-----------------------------------------

All patients underwent preoperative echocardiography (transthoracic


drug support. **B**: Mitral valve replacement with (partial or complete) preservation of the subvalvular apparatus or mitral valve repair vs. mitral valve replacement without (partial or complete) preservation of the subvalvular apparatus. **C**: Mitral valve replacement with (partial or complete) preservation of the subvalvular apparatus vs. mitral valve replacement without (partial or complete) preservation of the subvalvular apparatus. MVP = mitral valve plasty/repair; MVR = mitral valve replacement; SA = subvalvular apparatus; Pts = patients; + = censored.

Univariate and multivariate analyses showed that both MVR and concomitant CABG did not predict overall long-term survival. Patients who underwent MVR had a mean overall long-term survival (9.2 ± 1.5 years) that did not differ significantly from the mean overall long-term survival in patients who underwent mitral valve repair (14.0 ± 2.7 years, *P* = 0.111). Patients who did not undergo concomitant CABG had a mean overall long-term survivalmajor finding in this study is that (partial or complete) preservation of the SA in patients undergoing mitral valve surgery for post-MI PMR independently predicts and significantly improves overall long-term survival. Patients in which mitral valvular-ventricular continuity or papillary muscle-annular continuity was preserved (i.e. patients who underwent mitral valve repair or MVR with (partial or complete) preservation of the SA) had a significantly higher mean overall long-term survival (12.4 ± 1.6 years) compared to patients who underwent MVR without (partial or complete) preservation of the SA (5.4 ± 2.1 years, *P* = 0.008). A separate survival comparison in the replacement group also showed that mean overall long-term survival is significantly higher after MVR with (partial or complete) preservation of the SA (11.4 ± 1.9 years) compared to MVR without (partial or complete) preservation of the SA (5.4 ± 2.1 years, *P* = 0.037). In


fa...

Coop games

Collection by Taclis

This is for gathering the best coop games on Greenlight. I'll be adding as I sift through the games. Post suggestions if you want them considered.

Greenlight

Collection by Shichirobei

Juegos próximos de GL.

PixelProspector's Greenlight Picks

Collection by PixelProspector

All the games in this collection are also shown with screenshots on pinterest
http://pinterest.com/pixelprospector/greenlight-picks/
I've also created a new collection and video that showcases "55 Fresh Indie Games In 5 Minutes" (that are all on Green...

Pixel Perfect

Collection by Brunhildr

Best pixel art games on Greenlight that need your love.
If you have a suggestion, feel free do use the comments section!

Roguelike + sandbox + RPG + awesome stuff

Collection by Shustrik

Rogue-like, rpg, sandbox and similar games. Best of the best

Exato Top 10

Collection by Darknuke

This is a list of Exato Game Studio's top 10 favorite games onIt was Test century number 22 for Virat Kohli at Edgbaston, but was it one of his best? Our experts weigh in (2:04)

The opening thrusts in the India-versus-England encounter have provided a wonderful example of why Test cricket can be such an enticing spectacle.

Most of the ingredients that showcase Test cricket in its best light are on display in the UK: the pitches provide some encouragement for the bowlers, and the ball swings on a pretty regular basis. If what was on show at Edgbaston has difficulty filling seats, then Test cricket really is in deep trouble.

With swing bowling being such a crucial ingredient in producing a good contest, it's time to ask: "Should the Dukes ball be trialled world-wide with a view to using it in all


he criticized the details of some of Gewirth's arguments, questioning whether some of Gewirth's value judgments supported his conclusions, and suggested that Gewirth's conception of morality is too narrow.

Lomasky found some of Gewirth's arguments to be flawed, believed that Gewirth failed to establish the "rationally necessary supreme substantive principle" of morality, and noted that it "has been suggested that the universalisation extending the proscription against interference as a normative rule incumbent upon all agents is invalid." He also questioned "the concept of having a right to non-interference", arguing that it was doubtful that the fact that people want freedom and well-being logically supported the claim that people have rights to these things. However, he agreed with Gewirth's view that the purposive and voluntary nature of action shows thatthe nature of the magnetic ordering below $T_{L}$ is still unknown. Current hypotheses correspond to a lock-in of the phase of the modulation [@Regnault] or to a transition from a single-$\bf{k}$ structure to a double-$\bf{k}$ structure [@Jacoud2].

![Local (open symbols) and antiferromagnetic (full symbols) relaxation rate of Ce$_{0.8}$La$_{0.2}$Ru$_{2}$Si$_{2}$ as a function of temperature. Full circles correspond to measurements performed at $\textbf{Q}$=(0.69, 1, 0) while full squares correspond to measurements performed for $\textbf{Q}$=(0.72, 1, 0) i.e. slightly off the $\bf{k_1}$ peak position. The local relaxation was measured at $\bf{Q}$=(0.44, 1, 0).[]{data-label="onecolumnfigure"}](Fig4.ps){width="7cm" height="7cm"}

Figure 3b shows typical energy spectra obtained for $x$=0.2 at the constant momentum transfer $\bf{Q}$=(0.69, 1, 0) corresponding to the wave-vector $\bf{k_1}$ for $T$=2.6, 5.8 and 12.4 K (See Ref.[@Knafo1] for more details). Such spectra were analyzed using a


slight modifications of the index calculations you can save one element in that array, i.e. initialize it as
  self.tree = Array(repeating: .zero, count: count)

For example, the accumulation would be
func accumulated(at index: Int) -> T {
    guard index >= 0 else { return .zero }
    var sum = tree[0]
    var treeIndex = index
    while treeIndex > 0 {
        sum += tree[treeIndex]
        treeIndex -= treeIndex & -treeIndex
    }
    return sum
}

Finally, a single element can be retrieved from the tree array alone, by computing the difference of two tree nodes (this is also described in the Fenwick article).timings;

				}

				/**
				 * Return the number of seconds allocated for presenting
				 * all slides up to and including this one.
				 */
				function getTimeAllocated(timings) {

					var slides = Reveal.getSlides();
					var allocated = 0;
					var currentSlide = Reveal.getSlidePastCount();
					for (var i in slides.slice(0, currentSlide + 1)) {
						allocated += timings[i];
					}
					return allocated;

				}

				/**
				 * Create the timer and clock and start updating them
				 * at an interval.
				 */
				function setupTimer() {

					var start = new Date(),
					timeEl = document.querySelector( '.speaker-controls-time' ),
					clockEl = timeEl.querySelector( '.clock-value' ),
					hoursEl = timeEl.querySelector( '.hours-value' ),
					minutesEl = timeEl.querySelector( '.minutes-value' ),
					secondsEl = timeEl.querySelector( '.seconds-value' ),
					pacingTitleEl = timeEl.querySelector( '.pacing-title' ),
					pacingEl = timeEl.querySelector( '.pacing' ),
					pacingHoursEl = pacingEl.querySelector( '.hours-value' ),
					pacingMinutesEl = pacingEl.querySelector( '.minutes-value' ),
					pacingSecondsEl = pacingEl.querySelector( '.seconds-value' );

					var timings = getTimings();
					if (timings !== null) {
						pacingTitleEl.style.removeProperty('display');
						pacingEl.style.removeProperty('display');
					}

					function _displayTime( hrEl, minEl, secEl, time) {

						var sign = Math.sign(time) == -1 ? "-" : "";
						time = Math.abs(Math.round(time /


Check out an animated GIF leaked from Batman Vs. Superman of the Wonder Woman vs. Doomsday fight featuring Gal Gadot smiling as she takes on the Superman villain.

Regarding the Wonder Woman smile, Gal Gadot previously offered while discussing the Doomsday fight:

I did that. I remember after we did that take, Zack came to me and he said, "Did you just have a smirk?" I said "Yeah." And he asked, "Why? I think I like it, but why?" Well if he's gonna mess with her, then she's gonna mess with him. And she knows she's gonna win. At the end of the day Wonder Woman is a peace seeker. But when fight arrives, she can fight. She's a warrior and she enjoys the adrenaline of the fight.

Following Batman Vs.  FIELD_SET(*this, FIX::NoInstrumentParties);
    class NoInstrumentParties: public FIX::Group
    {
    public:
    NoInstrumentParties() : FIX::Group(1018,1019,FIX::message_order(1019,1050,1051,1052,0)) {}
      FIELD_SET(*this, FIX::InstrumentPartyID);
      FIELD_SET(*this, FIX::InstrumentPartyIDSource);
      FIELD_SET(*this, FIX::InstrumentPartyRole);
      FIELD_SET(*this, FIX::NoInstrumentPartySubIDs);
      class NoInstrumentPartySubIDs: public FIX::Group
      {
      public:
      NoInstrumentPartySubIDs() : FIX::Group(1052,1053,FIX::message_order(1053,1054,0)) {}
        FIELD_SET(*this, FIX::InstrumentPartySubID);
        FIELD_SET(*this, FIX::InstrumentPartySubIDType);
      };
    };
    FIELD_SET(*this, FIX::DeliveryForm);
    FIELD_SET(*this, FIX::PctAtRisk);
    FIELD_SET(*this, FIX::NoInstrAttrib);


   FIELD_SET(*this, FIX::AccruedInterestRate);
    FIELD_SET(*this, FIX::AccruedInterestAmt);
    FIELD_SET(*this, FIX::TotalAccruedInterestAmt);
    FIELD_SET(*this, FIX::InterestAtMaturity);
    FIELD_SET(*this, FIX::EndAccruedInterestAmt);
    FIELD_SET(*this, FIX::StartCash);
    FIELD_SET(*this, FIX::EndCash);
    FIELD_SET(*this, FIX::LegalConfirm);
    FIELD_SET(*this, FIX::NoStipulations);
    class NoStipulations: public FIX::Group
    {
    public:
    NoStipulations() : FIX::Group(232,233,FIX::message_order(233,234,0)) {}
      FIELD_SET(*this, FIX::StipulationType);
      FIELD_SET(*this, FIX::StipulationValue);
    };
    FIELD_SET(*this, FIX::YieldType);
    FIELD_SET(*this, FIX::Yield);
    FIELD_SET(*this, FIX::YieldCalcDate);
    FIELD_SET(*this, FIX::YieldRedemptionDate);
    FIELD_SET(*this, FIX::YieldRedemptionPrice);
    FIELD_SET(*this, FIX::YieldRedemptionPriceType);
    FIELD_SET(*this, FIX::NoPosAmt);
    class NoPosAmt: public FIX::Group
   {
    public:
    NoPosAmt() : FIX::Group(753,707,FIX::message_order(707,708,1055,0)) {}
      FIELD_SET(*this, FIX::PosAmtType);
      FIELD_SET(*this, FIX::PosAmt);
      FIELD_SET(*this, FIX::PositionCurrency);
    };
    FIELD_SET(*this, FIX::TotNoAllocs);
    FIELD_SET(*this, FIX::LastFragment);
    FIELD_SET(*this, FIX::NoAllocs);
    class NoAllocs: public FIX::Group
    {
    public:
    NoAllocs() : FIX::Group(78,79,FIX::message_order(79,661,573,366,80,467,81,989,1002,993,1047,992,539,208,209,161,360,361,12,13,479,497,153,154,119,737,120,736,155,156,742,741,136,576,635,780,172,169,170,171,0)) {}
      FIELD_SET(*this, FIX::AllocAccount);
      FIELD_SET(*this, FIX::AllocAcctIDSource);
      FIELD_SET(*this, FIX::MatchStatus);
      FIELD_SET(*this, FIX::AllocPrice);
      FIELD_SET(*this, FIX::AllocQty);
      FIELD_SET(*this, FIX::IndividualAllocID);
      FIELD_SET(*this, FIX::ProcessCode);


that suggest the diagnosis of pheochromocytoma.

Monitor patients with glaucoma after starting DUOPA, as it may cause increased intraocular pressure.

Drug Interactions: Monitor patients taking selective MAO-B inhibitors and carbidopa-levodopa for orthostatic hypotension. Concurrent administration with antihypertensives may result in postural hypotension, necessitating a dose reduction of the antihypertensive. Co-administration with dopamine D2 antagonists, isoniazid, or iron salts may reduce effectiveness of DUOPA.

Indication and Important Safety Information1-3

DUOPA enteral suspension is indicated for the treatment of motor fluctuations in patients with advanced Parkinson’s disease.

DUOPA is contraindicated in patients who are currently taking or have taken (within 2 weeks) a nonselective monoamine oxidase (MAO) inhibitor, as concurrent use can cause hypertension. A Percutaneous Endoscopic Gastrostomy with Jejunal Extension (PEG-J) is contraindicated with lack of transillumination/positive needle aspiration test; intestinal obstruction; sepsis; peritonitis;is good for them to be acquainted with our standards too, as much wire is out there in gage numbers. when they buy an inverter are they going to yell at the manufacturer that they don't know how wide a #10 wire is? they better find out real soon if they want to do this. links are fine, but why do it all for them as they learn nothing then as it pertains to more than just inverters as all equipment at some point will say what gage wires it can handle or should have?

It is just like spanish and english here.. The stores all have english and spanish on the doors and even starting to see it on the shelf as well. We are always converting our


not condemn our system as it originated in europe along with other measures so if you would have had the metric system in place during the colonizing of the states then we'd all be using it. i'll even make this a bit easier for you as 1 inch is equal to 25.4mm. an example of a common wire used in house wiring here is #12 or 12 gage. it's diameter is .08081 inches so this would be .08081x25.4=2.0526mm. a simple search is all you need to find the diameters of our wire in inches and i think you could handle it. if somebody wishes to implement changes to the calculator for their own use then please pm me. i would like to see it available at a europeanin the house. But with these wires you can even heat electrically, a 2000W space heater is using 9.5A.

I only use 2.5mm wire for the solar panels to the controller (5m or about 15feet with a maximum of 24A @ 12V) and seem to have no noticeable loss. Thicker wire is only used to link the batteries (10mm) and to connect the batteries to the inverter (also 10mm) but thats only 1m (3feet) wire.

i will change it. it wasn't my math as i originally thought, but my writing the #12 dia wrongly in inches. thanks for pointing this out. why do i have this strange feeling of being under a microscope all of a sudden? :?

The problem with the word "gage" is that is has meanings other than


confused.
as far as gauges go, i don't know why they did it that way. heck at first it confused me too so those that invented the system weren't doing it to be easilly understood by the commonfolk of the time.
i am glad people are looking at the calculator and i certainly hope people are using it. i do think it will be helpful when you have to initially run calculations to rough out a system. those calculations can be very time consuming for i know i used to do them for everybody here alot.
i also am not going to take all of the credit as arkiejon inputted the formuli and info i gave him to excel which was something i was unfamiliar with and he was. jon, in/*
 * DO NOT ALTER OR REMOVE COPYRIGHT NOTICES OR THIS HEADER.
 *
 * Copyright (c) 1997-2017 Oracle and/or its affiliates. All rights reserved.
 *
 * The contents of this file are subject to the terms of either the GNU
 * General Public License Version 2 only ("GPL") or the Common Development
 * and Distribution License("CDDL") (collectively, the "License").  You
 * may not use this file except in compliance with the License.  You can
 * obtain a copy of the License at
 * https://glassfish.dev.java.net/public/CDDL+GPL_1_1.html
 * or packager/legal/LICENSE.txt.  See the License for the specific
 * language governing permissions and limitations under the License.
 *
 * When distributing the software, include this License Header Notice in each
 * file and include the License file at packager/legal/LICENSE.txt.
 *


Q:

Capturing text within a page without refreshing on enter

I have a text box and input button on an HTML form. I want to simply capture the user input text and pass it to a Javascript function to alter settings on the same page without refreshing. Everything I try ends up refreshing the page and losing my settings. Don't need to submit the input. Of course, the button is no problem, just the enter key. I have found a lot of good info here, but still no success.
Here is my code very much simplified:
<html>
<head>
<title>Test</title>
</head>
<body>
<form id="codeform" >
<input name= "CodeTextBox" type="text" id="keywords" MAXLENGTH="20" SIZE="20" onkeypress="handleEnter(this, event, this.form)" />
<INPUT NAME="CodeButton" VALUE="click button" TYPE=BUTTON onClick=PromocodeValid(this.form)>
</FORM>
<script>
function PromocodeValid(form)
{
   alert( form.CodeTextBox.value );
}
</script>
<script>
function handleEnter(inField, e, form) {
var charCode;
  if(e && e.which){
" Seriously." "I expected her to have second thoughts, but..." " Amy." " Huh?" " Who?" " Ruby." "You sending or receiving bad news?" "Oh, what makes you think it's bad news?" "'Cause you've been staring at it like it's ticking." " [ sighs ] - [ phone rings ]" " [ phone stops ringing ]" " What's in it?" "Um, it's my last four uni results." "They need to be good or I'm not gonna qualify for post-grad funding." "Right." "Can you open it?" "Post-grad's kind of like one big nerd camp anyway, isn't it?" " Was I even close?" " It's all Ds." "[ squeals ]" "'D's for 'distinction', you dick!" "Yeah, I know!" "I know!" " [ both laugh ]" " I'm actually a genius!"


this part of your gig?" "Au pair some rich Arab's kid?" "You're not from the Middle East, are you?" "No." "She's from the Philippines." " Oh." " And she's here with me." "What do you mean she's 'with you'?" "I adopted her." "Whoa, Mel!" "Jeez." "What, you're in duty-free and you can't choose between cheap scotch and a baby?" "Uncle Sean's such a comedian, isn't he?" "Well, come on." "You haven't said hello yet." "Hello there, sweetheart." "What's your name, huh?" "Her traditional name's long and hard to pronounce." "Well, for English speakers." "The agency suggested I give her an Anglo-Saxon name." "Mmm." "And what did you choose?" "I..." "I haven't decided yet." " You know, nothing seems right." " Yeah." "OK." "Time for us to go." "the agency called me and said, "She's ready for you to pick her up."" "She was just waiting there." "Everything had been sorted." "And a part of me didn't want to say no." "I just didn't want to ignore that." "Sean, anything about me scream 'mummy' to you?" " [ laughs ]" " It doesn't, does it?" "Hey, come on." "So you're not gonna be a cookie baker, alright?" "But she's gonna learn other things." "She's gonna be strong." "Independent." " Funny... sometimes." " [ laughs ]" "Discerning about shoes." "Oh, you are just such a comfort." "Glad I can be of some service." "You know, you could help me by cancelling this thing this afternoon." "Why?" "'Cause I don't want all these people here seeing me messing


everything up." " I mean... [ scoffs ]" " Hey, come on." "Can I just say this one thing, OK?" "These people are your friends and maybe they'll be interested in givng you some support." "Hmm?" "I'm getting a full-time nanny when I get back." "[ laughs ] I bet." "[ baby cries ]" "Can you...?" "Uh-uh." "Come on." "You're gonna be very good at this." "You're just a little bit scared." "Oh!" "If you're here to pick up your pay, you'll have to come back in an hour." "Alright." "I'll wait." "Did you... always handle the money side of things?" "I mean, here?" "Or did someone else do it?" "I haven't short-changed anyone yet, Amy." "I'm not about to start with you." "[ scoffs ] No." "Ihis shit together?" "That's rhetorical, right?" "Look, it's not really my business, what you do with your money but if every time your dad asks for his cut and you flip out and thump a client?" "It's just on the employment front." "Is there an answer in there?" "Yep." "My answer is I'm not sure yet." "[ sighs ]" "You know, I heard you might cut me some slack on this because it's a personal problem." "I did cut you some slack." "I'll let you know when I've made my decision." "You get someone on a good day, you could end up with community service, a good behaviour bond." "And on a bad day?" "You could be looking at a custodial sentence." "We just need to make sure


got her mobile." "You should probably ring her." "[ murmurs ] Yep." "[ sighs ]" " You're gorgeous, aren't you?" " Yes, she is." "Aren't you, sweetheart?" "Hmm?" "What's her name again?" "Show me." "Oh, it's a tragic collision of consonants, Lauren." " Lord!" "[ laughs ]" " Oh, you're kidding!" "That's an alphabet." "Well, I just wannt use a few letters from her real name." "That way she's holding onto her roots." " What about Naggie?" " [ all laugh ]" "She's not a horse, Sean." "Rainy?" "I just think that might be a bit cruel, given she comes from a country where it floods." "You might have to rethink the rule about the letters, Mel." "What about Angel?" "Angel." "I like it." "OK - more champagne."come after you, they'll pull out all stops." "So why not just cut to the chase?" "'Cause I blacked out for a reason, Paul " "I was pissed." "She's not depressed or taking any weird kind of drugs or anything?" "Not that I know of." "What about you?" "I haven't been depressed or taking any weird kinds of drugs either!" "That doesn't always guarantee lucid thinking." "Are you going somewhere with this?" "I could." " But...?" " It might push things over the edge." "Oh, go on!" "Live dangerously." "Your ex - the married one." "I take it back - live timidly." "So tell me - a married man messes you up, you start doing sex work?" "It's not that simple." "It's a job where you see dozens


Lauren, you, um you put so much pressure on yourself to make everything right." "If you stop that, you..." "you might not need to drink." "I've got a lot to think about, I know." "I want to get back to who I was." "[ laughs ] Before everything else happened." "Well, if you need to talk..." " Thanks." " I'm pretty good with mess." "Oh, I don't want to be your mess!" "Well, you can't do this on your own." "I think I have to." "For now." "I probably should go." "So you'll keep in touch?" "Promise?" "I promise." " She's finally asleep." " Oh." " What you doing?" " Looking for a ticket." "Oh, yeah." "Find one?" "Not the one I want yet." "See, the one Iinto?

Robert Rosenkranz:

Well, I come at this from a couple of aspects of my own background. So, I run an insurance company as my day job. And I'm very, very cognizant about risk and about statistics. And while obviously there are risks associated with the admission of any group of refugees, I'm goin g to be listening to hear those risks quantified and put in the perspective of other risks that we take every day.

00:02:13 I also have a background as an economist. And -- which, for me, means that I'm going to be listening with a view toward efficiency as well.

John Donvan:

[affirmative]

Robert Rosenkranz:

Because it's clear that there are going to be very substantial costs incurred if we were to admit a large number -- 100,000 -- Syrian refugees.


The victims of sexual abuse by refugees and migrants in Germany, and Austria, and Sweden -- since the turn of the year -- now number nearly 1,000. The giddy mood of the fall has faded.

00:21:03 Almost two -thirds of Germans say their country has accepted too many refugees. And here in the United States, too, a new sobriety about Syrian refugees is taking hold.

Jessica and I welcome tonight's debate as a step toward this new sobriety. Here's ourplan for tonight. I will open by arguing that mass resettlement of refugees in the Middle East is not in the American interest. When I say "mass," I mean mass. Clearly, there are individuals and families wh

o need to be in the West, who have family connections, who belong to thearrested for activities outside the United States that were

not targeted at Americans. So I ask you to sort of put in relative context the security risk, but I want to add also what U.S. government agencies do to help bring that risk down. I won't go into all of the detail now, although I would be delighted if David and Jessica want to do that.

00:31:06 I would just say this. The process of screening is very long. It takes 18 to 24 months for the average Syrian refugee to get through the security screening process. Multiple U.S.

government intelligence agen cies, including the CIA, the National Counterterrorism Center, the FBI, the Defense Department, the State Department, and other intelligence agencies are involved in building a dossier for each refugee


you confirm all the prejudice at the heart of their message. It's a very, very, simple point, and we must look --

John Donvan:

David, just -- David --

David Miliband:

[inaudible]

John Donvan:

-- I think that your opponents -- your opponents are not saying, "No Syrians should come to this country." They are very explicit about that.

David Miliband:

Well, how many are they saying? I mean, please ask them how many Syrians would be the right number?

John Donvan:

Okay, we'll get to that, but I -- I will get to that, but I first want to have you respond --

[laughter]

-- I first want to have you respond to your opponent's point on the propaganda point.

00:46:07 [applause]

David Frum:

Well, let's look at Westerners who actually have been recruited to ISIS, and let's see what their grievancesthe safety of their society. And if this argument is right, you are crediting ISIS as a kind of global Islamic civil rights organization, and I really urge you to reject that idea.

John Donvan:

Robert Ford.

Robert Ford:

Thank you.

[laughter]

First, everybody -- none of us here like the Islamic State, and I certainly wouldn't for a minute -- no, I mean --

[applause]--

they murdered -- I mean, I know one of the people they murdered. And he was a wonderful man, was a journalist, Jim Foley.

00:48:00 So it's not that they're a civil rights organization and they have facts. It's all about perception. It's all about perception. And the Islamic State -- I mean, I'm sure many of the people in the audience, many all of y ou, have seen these videos


months. Just a few da ys ago an ISIS Syrian bomber targeted German tourists in Istanbul. You don't get a thank you note.

John Donvan:

What does the German experience tell us?

[applause]

David Miliband.

David Miliband:

I've actually sat in the chair that oversees the intelligence agencies in the U.K. and I can tel l you exactly what the Jihadist threat is designed to do. It's designed to foment the argument that western values are inimical to Muslim values and by saying we don't want your people in our country you are confirming exactly the point that they are making and it's really wrong to underestimate the importance of the battle of ideas.

00:50:15 The core element of our argument of this part of the argument is that we will not win the argumentthat.David Frum:

But -- this is something Jessica knows much more about than I do --

John Donvan:

Okay.

David Frum:

-- but --

John Donvan:

[unintelligible] Jessica. No. I'll give it to Jessica --

David Frum:

Let's understand what he said. Just one sentence and I'll turn it over -- that what he said is we don't rely on the Syrian government, which is great. Don't do that. But what do you rely on other than the word of the person himself --

John Donvan:

All right.

David Frum:

-- or herself?

John Donvan:

Jessica, take the response --

Jessica Vaughn:

Okay.

John Donvan:

-- to Robert.

Jessica Vaughn:

Sure. And again, it's important to understand -- it's the U.N. that decides whether someone is a refugee.

00:56:06 And they'r e selecting people from the population who, by the way, are among the poorest of the poor in that


Refugees.

01:19:03 John Donvan:

A question right down here, sir. If you can stand up. Folks, I just wanted to say, if you're raising your hands upstairs, I literally can't see you. So, I apologize for not going upstairs at all. But if somebody wants to come downstairs, and I -- you know, I see that effort made, and you walk through the doo rs in the back, I'll try to call on you. Go ahead, sir.

Male Speaker:

Hi. My name is Max. I have a "what if" question, and it's, what if the motion had the word "or" at the end of it? So, what if the motion was The U.S. Should Let In 100,000 Syrian Refugees or -- and what do you think would --

John Donvan:

I'm --

Male Speaker:

-- happenfamilies who've lost the hope that they'll ever be a chance for them to rebuild their lives. I meet these families. We serve them every day, including those who are trying -- who arrive in the United States destined for a state and the governor -- a state in the U.S. and the governor says they can't go there. They stop in New York City. I saw -- I met that f amily last month. That family w as running a realty business in Deraa

where the civil war started. One of the cousins got hit by an Assad barrel bomb. The daughter is still in Deraa and the day before I met that family the Russians had dropped a bomb nex t door to her. If you are


going to vote against the motion tonight, you'regoing to have to be willing to tell that family that you don't want them in your country and I think those people have a right --

deserve the opportunity to come to this country.

01:32:00 I believe that in the course of what has been a very good discussion, the case against the motion has crumbled. Has a Syrian ever been arrested on terrorism charges in the United States? A Syrian refugee. No. Can the U.S. choose who it takes ? Yes. Is the U.S.

situation comparable to that in Europe? No. And does a vote against the motion play into division hatred and fear? Of course it does. It's obvious. And as a father of two young boys, as a leader ofcell surface, like MHC-I and Fas \[[@B48-cancers-11-01172],[@B49-cancers-11-01172]\], which increases tumor cell killing by immune cells. Therefore, targeting immune suppressive mechanisms provides opportunities for therapeutic intervention in combination with chemo/radiotherapy.

5. Immune Microenvironments in CRC {#sec5-cancers-11-01172}
==================================

Given the mechanistic importance of PD-L1 expression in anti-tumor ICB, its detection as a predictive biomarker has justifiably garnered much attention. However, its detection by immunohistochemistry (IHC) is confounded by multiple issues (e.g., variable detection antibodies, differing IHC cutoffs, tissue preparation, and processing variability) and the identities of the various cell types being stained (e.g., tumor or myeloid cells). Emerging data suggest that patients whose tumors (e.g., lung cancer or melanoma) over-express PD-L1 by IHC show improved clinical outcomes in response to ICB. In mCRC, PD-L1-positive expression in tumor cells ranges between 22% and 38%


cancer cells through MCT1 and used to generate pyruvate through the activity of LDH-B, which is also highly expressed in Cluster 1.

Mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) and v-Raf murine sarcoma viral oncogene homolog B (BRAF) contribute to a glycolytic reprogramming that fuels the conversion of glucose to lactate \[[@B72-cancers-11-01172]\]. For instance, mutant KRAS in pancreatic cancer has been shown to activate glycolytic and hexosamine biosynthesis and a non-oxidative branch of the pentose phosphate pathways \[[@B73-cancers-11-01172]\]. Moreover, in pancreatic cancer, mutant KRAS reprograms the use of glutamine-derived glutamate, such that instead of using glutamate dehydrogenase (GLUD1) to convert glutamate into α-ketoglutarate and TCA entry, glutamine-derived aspartate is converted into oxaloacetate by mutant KRAS-dependent upregulated GOT1 in the cytoplasm \[[@B74-cancers-11-01172]\]. The resulting oxaloacetate can be converted intoRussia is the largest country on earth, with enormous tracts of land that have only been opened to foreign travelers in the last few years. It takes over 8 hours by plane from Moscow to reach Vladivostok on the Pacific coast. To the west of the Ural Mountains, stretching south to the Black Sea and below the Arctic Sea, lies a broad plain with low hills where the historical core of the Russian nation is located. East of the Urals from the border of Kazakhstan, China and Mongolia and extending north to the Arctic coast lies Siberia - a scarcely- populated area covered by primeval forest, swamps and tundra in the north and mountainous terrain in the south.

…find the largest freshwater lake in the world, rivers and forests


Beach et al. shows another different modern golf club with a connection assembly that allows the shaft to be easily disconnected form the club head. The connection assembly includes a removable hosel sleeve that allows a shaft to be supported at a desired predetermined orientation relative to the club head. In this manner, the shaft loft and/or lie angle of the club can be adjusted without resorting to traditional bending of the shaft.
U.S. Pat. No. 7,722,475 to Thomas et al. shows another different modern golf club head that releasably engages with a shaft so that the club head and the shaft can be readily interchanged and/or so that the shaft position with respect to the club head can be readily changed. The assemblies for connecting the club headgolf club head resist twisting when impacting a golf ball.
Hence it can be seen, there is tremendous need in the field for a golf club that incorporates the technological advancements associated with golf clubs that can incorporate all of the components necessary to offer a golf club that is releasable, adjustable, and/or interchangeable without unduly adding to the size and weight of the hosel. More specifically, there is a need in the field for a golf club head having an adjustable and interchangeable hosel, wherein the weight associated with the components are minimized, yielding a CG location that is lower and further back to improve the performance of the golf club head.


Sweetfields Farm Is The Place You Want To Be!

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Property Description

Sweetfields is a beautiful 100 year old farmhouse that sits proudly on 50 aers of farmland . Bring the whole family ! Plenty of room for the perfect family reunion, small country chic wedding and corporate meetings. Just 10 min to wasaga beach, , take along a picnic basket full of fresh fruit! Berry picking is always a hit with the kids and grandparents! May dad would enjoy a round of golf and a spa for mom? And finish a perfect day in the county with fresh pasta bar or for a special evening ,let us know and we can book you at one of the many hidden round activities include skiing at blueGreule Jr/Getty Images)

Photo By: Otto Greule Jr

Copyright Getty Images

ANAHEIM, CA - APRIL 10: General view as the Kansas City Royals and the Los Angeles Angels of Anaheim line the field with a giant American flag during the national anthem for the Angels home opener at Angel Stadium of Anaheim on April 10, 2015 in Anaheim, California. (Photo by Stephen Dunn/Getty Images)

Photo By: Stephen Dunn

Copyright Getty Images

HOUSTON, TX - APRIL 01: A general view of Minute Maid Park during a game between the New York Yankees and Houston Astros on opening day on April 1, 2014 in Houston, Texas. (Photo by Bob Levey/Getty Images)

Photo By: Bob Levey

Copyright Getty Images

MINNEAPOLIS, MN - APRIL 11: The Chicago White Sox and Minnesota Twins line up for the National Anthem before the home


up,' 'more reckless than ever,' and unable to support their families

"The electronic logs are supposed to make it safer, but really it has created a hazardous race to beat the clock," Manley said. "Drivers are now more reckless than ever trying to make it to their destination before the clock runs out with the mandatory breaks and such."

Here's what's set to change

The FMCSA said that more than 5,200 public comments had opined to the agency about what needed to change in the HOS law.

"We listened directly to the concerns of drivers for rules that are safer and have more flexibility — and we have acted," the FMCSA administrator, Raymond Martinez, said in a statement. "We encourage everyone to review and comment on this proposal."

Five measures are part ofat the end of their shift. Under adverse driving conditions, the 14-hour window could be extended by two hours. For short-haul truckers, the maximum on-duty period could be extended to 14 hours from 12 and the distance limit to 150 miles from 100.

The FMCSA estimated that these changes would save $274 million across the US economy.

Are you a truck driver with opinions on the proposed changes to the HOS laws? Email the reporter at rpremack@businessinsider.com.


And when the FBI moves in--more interested in nabbing a Nazi nutcase than a malicious mobster murderer--the local cops clear out, leaving Judith, Joe and irrepressible cousin Renie to find out who whacked the wiseguy before the hits keep coming.

Product Description

About the Author

Seattle native Mary Daheim began telling stories with pictures when she was four. Since she could neither read nor write, and her artistic talent was questionable, her narratives were sometimes hard to follow. By second grade, she had learned to string together both subjects and predicates, and hasn't stopped writing since. A former newspaper reporter and public relations consultant, Daheims first of seven historical romances was published in 1983. In addition to Avon Books' Bed-and-Breakfast series featuring Judith McMonigle Flynn, Daheim also pens the Alpine mysteriesinterrelationships enhance an entertaining who-done-it. Mary Daheim should return to the bestseller list with a novel that will have readers seeking the previous five Bed and Breakfast books.

This is one book in a series of bed-and-breakfast mysteries set in Seattle, Washington. Anyone familiar with the city can tell that the author, Mary Daheim, has changed the place names, but retained the feel of the city in accurate descriptions. Heraldsgate Hill is really Queen Anne Hill. Norway General Hospital is really Swedish Hospital. Papaya Pete's restaurant is really Trader Vics. Donner and Blitzen department store is really the now defunct Frederick and Nelsons. Nordquist is Nordstroms. The Belle Epoch is The Bon Marche, now known just as The Bon. Moonbeams coffee house is really Starbucks, and so on. The


descriptions are so accurately and fondly drawn that the reader experiences a warm sense of being there, especially if one has actually lived in Seattle at one time. The relationships of the characters are sometimes feisty but honest and often very funny. I recommend this whole series.

Judith Flynn, proprietor of Hillside Manor Bed and Breakfast thinks that it's business as usual as her guests arrive for the weekend. It seems like a typical group with a single man, a newly-married couple, a mother and son, a pair of nursery school teachers, and a surly couple from Chicago. However, there is soon a dead body at the B & B and it becomes apparent that no one is who he says he is. As usual Judith claims to haveFlorida to North Carolina -- after slamming Haiti and other countries in the Caribbean. Hide Caption 1 of 80 Photos: Hurricane Matthew's path of destruction Workers repair downed power lines in Daytona Beach, Florida, on October 10. Hide Caption 2 of 80 Photos: Hurricane Matthew's path of destruction Rescue teams maneuver through floodwaters in Lumberton, North Carolina, on October 10. President Barack Obama has declared a major disaster in North Carolina and ordered federal aid to supplement state, tribal and local recovery efforts. Hide Caption 3 of 80 Photos: Hurricane Matthew's path of destruction Floodwaters inundate a home in Lumberton on October 10. Hide Caption 4 of 80 Photos: Hurricane Matthew's path of destruction Floodwaters surround a house in Nichols, South Carolina, on October 10. Hide Caption 5


Internet. In each of these embodiments of multiple-player games, players vie against each other and xe2x80x9cthe machine,xe2x80x9d which adds an additional layer of excitement to the gaming experience.
One example of a networked, multiple-player game is disclosed in U.S. Pat. No. 6,179,713 to James et al. The James et al. patent discloses a turn-based, multiple-player, Internet game for a large number of players in which players can input moves sequentially, i.e., on their turn. A salient feature of the James et al. patent is that players are allowed to change moves during a turn. A problem with the James et al. patent is that the game is time-consuming; hence, some players may lose interest and abort playing the game, which may leave a xe2x80x9cholexe2x80x9d in the game. Furthermore, thethis viewpoint, any increase in productivity is seen as a sign of a real reduction in resource use. Even if total resource use grows, it is argued that without the improvement in resource productivity, the growth in resource use "would be even larger". Two quotes help illustrate this point of view. "Weighted by 1990 activity levels, intensities were roughly 15−20% lower in 1994/5 than in 1973, which in turn meant real savings of energy; energy demand in IEA countries is roughly this much below what it would have been for the same GDP had these savings not occurred."([@ref13]) "We define dematerialization, or resource sparing by consumer behavior, as a declining \[energy intensity\]\...".([@ref5])

Resource productivity, and its change over time, are often used in conjunction with projections of economic and


choose energy (two alternative data sets in energy units), material flows, and carbon emissions (in mass units). The first energy accounting system is that of the International Energy Agency, at the Total Primary Energy Supply (TPES) level.^[@ref24],[@ref25]^ The IEA includes biomass sources only when they are used for heating or cooking purposes, not when used as food or fodder. In fact, TPES has no "biomass" category: the closest equivalent is "Combustible renewables and waste", which includes both wood fuel and municipal waste incinerators with energy recovery. Thus we also analyze Domestic Energy Consumption (DEC), which encompasses an energy estimate of all biomass inputs to the society: as energy, food, fodder, and materials, as well as fossil, nuclear, and high-tech renewables.^[@ref26],[@ref27]^ For materials, Domestic Material Consumption (DMC) comprises foursent him off for it because he was alerted to it by his linesman.

(Image: Surrey Advertiser)

"One of our spectators has made a formal complaint so we're waiting to see what will happen from there. But there's no secret about it. It's been reported to the police."

Crocombe, 24, is a former Oxford goalkeeper who joined Salford in May.


consideration, threw four interceptions, setting the tone for a sloppy game on that side of the ball. Up to that point, he’d tossed just one pick, in the Buckeyes’ Week 2 loss to Oklahoma, but on Saturday, he added two more to his season total. Fortunately, Michigan State wasn’t able to manufacture a single point off the mistakes, but Barrett’s inconsistency in recent weeks—against good opponents—is something to keep an eye on.

The Ohio State offense still flourished Saturday, and Barrett’s stat line was plenty respectable: He finished with two touchdown passes and 183 yards in the air. Michigan State also let the Buckeyes run all over them; running backs J.K. Dobbins and Mike Weber each finished with more than 100 yards on the ground. But just as notablewas the Buckeye defense, which finished with six sacks, toppling Michigan State quarterback Brian Lewerke with players from its first-, second- and third-string defenses. The Spartans’ offense finished with just 195 total yards, kicking a single field goal. Its average drive covered 16 yards. And though the Buckeyes have been just fine on defense so far this season, Saturday’s performance was by far their best. Blanking Rutgers and holding Army to a touchdown hardly compare to limiting an offense that’s been averaging 402 yards per game to fewer than 200.

From here, Ohio State controls its path to Indianapolis. Unlike a year ago, when they missed the conference championship game but still earned a playoff berth, the Buckeyes need to win their division to have a hope at being


probably closer to 1). If they have a high debt burden, with falling real incomes, they can earn a good return by selling their youths to clubs of high market power. Real Sociedad sold Illarramendi for €35 million to Real Madrid; Málaga sold Isco to Real Madrid for €30 million; Sevilla sold Geoffrey Kondogbia for €20 million; Atlético Madrid has had to raise the buy-out clauses for their youth players, in case they can’t match their wealthy competitors’ wage offers. The result is that clubs find it difficult to retain the talent they produce at home. In other words, clubs with higher market power can offer their less well off, debt-constrained competitors a price that compensates them for foregoing the opportunity to use (and develop) their youths andsuperior alternative to waiting for the price level to fall, because many individual prices do not always fall to their market-clearing level. Maybe what we need today is more money (although, given that the price level has been rising I’m skeptical of the idea that a demand shortage is currently the most important deterrent to economic recovery). But, lifting the constraints on public finance is not a solution. Maybe the current administration, and even many administrations to follow, can be trusted, but political institutions can deteriorate, especially when government is under financial pressure. The reason we don’t voluntarily dismantle them voluntarily is because the risk of gratuitous inflationary public finance is very real, and it has been something governments have resorted to since the beginning of governed civilization.


This invention relates to a tamper-proof closure for a bottle and the like which includes a stopper which is threadable onto and off of the bottle, a proofing band connected to the stopper and having rupture bridge connections which can be broken to remove the band, and detents formed on the proofing band and engaged with corresponding stops on the bottle.
As is known, such closures, while being on the whole satisfactory and extensively utilized, still have the disadvantage of providing scant evidence of tampering, and on first use, they tend to behave in an uncertain, random fashion, that is to perform inconsistently.
Where the proofing band, once separated from the cap-type stopper, remains with the bottle, application of little skill is all that is required to re-attach it to
 * Calculates the standard deviation of the elements in the input vector.
 * The underlying algorithm is used:
 *
 *

 * 	Result = sqrt((sumOfSquares - sum2 / blockSize) / (blockSize - 1))
 *
 *	   where, sumOfSquares = pSrc[0] * pSrc[0] + pSrc[1] * pSrc[1] + ... + pSrc[blockSize-1] * pSrc[blockSize-1]
 *
 *	                   sum = pSrc[0] + pSrc[1] + pSrc[2] + ... + pSrc[blockSize-1]
 *

 *
 * There


   DruidConnectionImpl(String url, String coordinatorUrl) {
        this.url = Preconditions.checkNotNull(url);
        this.coordinatorUrl = Preconditions.checkNotNull(coordinatorUrl);
    }

    /** Executes a query request.
     *
     * @param queryType Query type
     * @param data Data to post
     * @param sink Sink to which to send the parsed rows
     * @param fieldNames Names of fields
     * @param fieldTypes Types of fields (never null, but elements may be null)
     * @param page Page definition (in/out)
     */
    public void request(QueryType queryType,       } catch (IOException | InterruptedException e) {
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        Row.RowBuilder rowBuilder, JsonParser parser) throws IOException {
        parseFields(fieldNames, fieldTypes, -1, rowBuilder, parser);
    }

    private void parseFields(List<String> fieldNames, List<ColumnMetaData.Rep> fieldTypes,
        int posTimestampField, Row.RowBuilder rowBuilder, JsonParser parser) throws IOException {
        while (parser.nextToken() == JsonToken.FIELD_NAME) {
            parseField(fieldNames,


 }
    }

    private void expectObjectField(JsonParser parser, String name)
        throws IOException {
        expect(parser, JsonToken.FIELD_NAME);
        if (!parser.getCurrentName().equals(name)) {
            throw new RuntimeException("expected field " + name + ", got "
                + parser.getCurrentName());
        }
        expect(parser, JsonToken.START_OBJECT);
        while (parser.nextToken() != JsonToken.END_OBJECT) {
            // empty
             }
        } catch (IOException e) {
            throw new RuntimeException(e);
        }
    }

    /** Reads data source names from Druid. */
    Set<String> tableNames() {
        final Map<String, String> requestHeaders =
            ImmutableMap.of("Content-Type", "application/json");
        final String data = null;
        final String url = coordinatorUrl + "/druid/coordinator/v1/metadata/datasources";
//        if (CalcitePrepareImpl.DEBUG) {
//


straps so i would be kind of sealed in to the helmet and not have to cut away a lot of the bottom portion of the helmet OR have too big of a scale so it would be either too cut away or too big. THOUGHTS??My last idea is for the boots. I haven't seen any Mk. V's on here with boot covers (maybe a bad search??) I test fitted the boots and they fit PERFECTLY over the boots im going to use for this armor project. I plan on fiberglassing the OUTSIDE (so i don't lose the perfect fit) and then putting a ton of bondo over them to make them look good, cut them in half on the black detail lines, and attaching them together withdamage will result before notice can be served and a hearing had. (Kable Printing Co. v. Mount Morris Bookbinders Union Local 65-B (1976), 63 Ill.2d 514, 523.) The Board made no allegation that in the time it would take to notify MEA's attorney that the Board was seeking an injunction there would be greater immediate and irreparable injury than without notice.
It is axiomatic that an injunction is an extraordinary remedy requiring urgent and extreme circumstances before it may be issued without notice. In other circumstances where the identity and location of defendants and their counsel may not be known as it was here, the allegations of plaintiff's complaint might be considered sufficient to dispense with notice prior to applying for the injunction. Certainly the circumstances here are sufficient


Rack::Test::Methods helpers, but I don't want to violate DRY - I'd like Mime formats only to be defined there.

A:

Please try like this:
request.env['HTTP_FOO_HEADER'] = 'foo header'

Ask HN: To Ask for CC on Signup or Not? - tronathan

The prevailing idea about converting customers on freemium websites is to require a credit card signup right off the bat, at signup time, to validate that users are indeed willing to pay for your product, and to increase conversions.
This method was used by Basecamp for a long time, requiring credit card on signup, but in the new version of Basecamp, a credit card is no longer required.
In StartupsForTheRestOfUs Podcast, the author/developer/owner-preneur of HitTail.com said he's asking for CC's right away and in the episode I listed to, he said that he hadn't reached the 30-day post signup time to see if those people converted, but he seems to be a fan of requiring CC on signup.
I'm building


range of 0.1 to 0.5 mA. Muscle force was further manipulated by selective release of blocking currents (600 Hz, 1.7 to 0.4 mA) superimposed over regular stimulation (50 Hz, 0.3 to 1.7 mA). Nerve and muscle vitality were histologically confirmed. Long-term, low-intensity conduction capabilities, fine tuning, good tolerance of implanted electrodes, and lack of fatigue suggest that reinnervating pedicles may be successfully used for pacing when clinically indicated.Experimental cross-infections by Perkinsus marinus and P. chesapeaki in three sympatric species of Chesapeake Bay oysters and clams.
In controlled laboratory transmission experiments, uniform doses of axenic in vitro isolate cultures of Perkinsus marinus from a Crassostrea virginica oyster, and of independent P. chesapeaki isolates from Chesapeake Bay Mya arenaria and Macoma balthica clams, were used to reciprocally challenge Perkinsus sp.-free C. virginica, M. arenaria, and M. balthica experimental hosts. Following mantle cavity inoculations, all 3 experimental hosts acquired high incidences (30 to 100%) of infections by each of the 3 Perkinsus sp. isolates, based on PCR assays of DNAs from experimental host tissues that were collected through 60 d post-inoculation. Lesions containing proliferating pathogen cells were documented histologically in tissues of all experimental host species challenged with all


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abstract: 'We show how statistical thermodynamics can be formulated in situations in which thermodynamics applies, while equilibrium statistical mechanics does not. A typical case is, in the words of Landau and Lifshitz, that of partial (or incomplete) equilibrium. One has a system of interest in equilibrium with the environment, and measures one of its quantities, for example its specific heat, by raising the temperature of the environment. However, within the observation time the global system settles down to a state of apparent equilibrium, so that the measured value of the specific heat is different from the equilibrium one. In such cases [formulæ]{} for quantities such as the effective specific heat exist, which are provided by Fluctuation Dissipation theory. However, what is lacking is a proof that internal energymight be called *reference state*), which corresponds to some definite values $\overline
\alpha=\overline \alpha(T,p)$ of the internal parameters $\alpha$ for which the measure is invariant. In particular the invariant measure could be a global Gibbs one. This is the typical case one considers in discussing partial equilibrium. The more general case considered above is of interest when discussing metastability.

Given one such equilibrium state with density $$\label{notazione2bis}
\rho(T,p,\overline \alpha ;z)\ ,$$ we then introduce the state in which the external parameters have been incremented, *while the values of the internal parameters are kept constant*. In general such a measure will not be invariant, i.e., will correspond to a nonequilibrium situation, leading to a process. The corresponding measure will have a density $$\label{notazione2}
 \rho(T+{\mathrm{d}}T,p+{\mathrm{d}}p,  \overline \alpha; z)\ .$$ Notice that,