+390 if it is better than +390, or −460 if it is worse than −460. He found that White's advantage is equivalent to 35 rating points, i.e. if White has a rating 35 points below Black's, each player will have an expected score of 50%. Sonas also found that White's advantage is smaller (53%) in rapid games than in games at a slower ("classical") time control. In the 462 games played at the 2009 World Blitz Chess Championship, White scored only 52.16% (W38.96 D26.41 L34.63).

Other writers conclude that there is a positive correlation between the players' ratings and White's score. According to GM Evgeny Sveshnikov, statistics show that White has no advantage over Black in games between beginners, but "if the players are stronger, White has the lead". AnWhite cannot escape the checks.)

However, Georgiev and Kolev's pessimistic assessment of 6.Bg5 has since been called into question, as White succeeded with 10.e5 (another critical line) in several later high-level games. GM Zaven Andriasyan wrote in 2013 that after 10.f5, "a forced draw results", but that after 10.e5, "we reach a very sharp position, with mutual chances."

White wins
Although it is very much a minority view, three prominent twentieth-century masters claimed that White's advantage should or may be decisive with best play.

White wins with 1.e4

Weaver Adams, then one of the leading American masters, was the best-known proponent of this view, which he introduced in his 1939 book White to Play and Win, and continued to expound in later books and articles until shortly before his death in 1963. Adams


goes so far as to claim that, "The tale of White's advantage is a delusion; belief in it is based on mass psychosis." Rowson writes that Adorján's "contention is one of the most important chess ideas of the last two decades ... because it has shaken our assumption that White begins the game with some advantage, and revealed its ideological nature". However, Rowson rejects Adorján's claim that White has essentially no advantage, reasoning that White is better' and 'Black is OK' need not be mutually exclusive claims".

In one of Adorján's books, GM Lajos Portisch opined that "at least two-thirds of all 'tested' openings give White an apparent advantage." According to Portisch, for Black, "The root of the problem is that very few people know which are the openingsBlack's set-up in the Sicilian is fine as a reactive system, but not worth much when trying to claim the initiative as White. This is true because Black is able to react to the specific plan White chooses; in Suba's terms, his information is indeed a move greater! Furthermore, he is able to take advantage of dead equal positions which White (hoping to retain the advantage of the first move) would normally avoid.

Watson also observes, "Similarly, the Dutch Defence looks particularly sterile when White achieves the reversed positions a tempo up (it turns out that he has nothing useful to do!); and indeed, many standard Black openings are not very inspiring when one gets them as White, tempo in hand." GM Alex Yermolinsky likewise notes that GM Vladimir


examples of White losses in the Exchange French are M. Gurevich–Short and Tatai–Korchnoi. In M. Gurevich–Short, a game between two of the world's leading players, White needed only a draw to qualify for the Candidates Matches, while Black needed to win. Gurevich played passively and was outplayed by Short, who achieved the necessary win. In Tatai–Korchnoi, the Italian IM fell victim to Korchnoi's whirlwind , losing in just 14 moves.

Rowson gives the following example of Black outplaying White from the Symmetrical Variation of the English Opening. He remarks, "there is something compelling about Black's strategy. He seems to be saying: 'I will copy all your good moves, and as soon as you make a bad move, I won't copy you any more!

Hodgson–Arkell, Newcastle 2001: 1. c4 c5 2.

                                                COURT OF APPEALS
                                                 SECOND
DISTRICT OF TEXAS
                                                                 FORT
WORTH

                                        NO.
2-08-056-CR

MARIA LUISA DOMINGUEZ                                                   APPELLANT

                                                   V.

THE
STATE OF TEXAS                                                                STATE

                                              ------------

        FROM CRIMINAL DISTRICT
COURT NO. 2 OF TARRANT COUNTY

                                              ------------

                                MEMORANDUM OPINION[1]

                                              ------------
                                          I.  Introduction
In one issue, Appellant Maria Luisa Dominguez
appeals the trial court=s order revoking her community
supervision.  We affirm.

                          II.  Factual and Procedural Background
In July 2007, Dominguez pleaded guilty to the
offense of unauthorized use of a motor vehicle.
Pursuant to a plea agreement, the trial court placed Dominguez on three
years=
deferred adjudication community supervision.
Less than six months later, the State filed a motion to adjudicate,
alleging that Dominguez had violated her community supervision by (1) using
cocaine and marijuana, (2) not attending treatment for substance abuse, and (3)
failing to report to the probation department on more than one occasion.  Dominguez waived her right to a


allegations contained in the motions were true, they do not provide a
basis for determining that Dominguez was incompetent at the time she waived her
right to an adjudication hearing or entered a plea of true.  Fuller v. State, 253 S.W.3d 220, 228
(Tex. Crim. App. 2008) (stating that the test for determining a defendant=s competency is the
defendant=s Apresent ability@ to consult with her
lawyer with a reasonable degree of rational understanding).

 Quentin Kral,$^{1,2}$[^1] Sebastian Marino, $^{1}$ Mark C. Wyatt,$^{1}$ Mihkel Kama,$^{1}$ and\
    $^{1}$Institute of Astronomy, University of Cambridge, Madingley Road, Cambridge CB3 0HA, UK\
    $^{2}$LESIA, Observatoire de Paris, Universit[é]{} PSL, CNRS, Sorbonne Universit[é]{}, Univ. Paris Diderot,\
    Sorbonne Paris Cit[é]{}, 5 place Jules Janssen, 92195 Meudon, France\
    $^{3}$Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138, USA\
date: 'Accepted 1928 December 15. Received 1928 December 14; in original form 1928 October 11'
title: 'Imaging \[CI\] around HD 131835: reinterpreting young debris discs with protoplanetary disc levels of CO gas as shielded secondary discs'
---

\[firstpage\]

accretion, accretion discs – star:HD 131835, HD 21997, HD 138813, 49 Ceti, HD 32297, HD 156623, HD 121191, HD 121617, HD 131488 – circumstellar matter –


@2015ApJ...814...42M]. By comparing the posterior distributions of the gas and dust disc, we find that the inclination and PA of both discs are very similar. The astrometric offsets are also consistent between the two data sets. The best fit is for a stellar radial velocity around 3.57$\pm$0.1 km/s (heliocentric frame), which is consistent with what has been found by previous studies [@2006ApJ...644..525M; @2015ApJ...814...42M] and shows that the gas is comoving with the star, as expected.

### Gaussian fit {#gaussfit}

![image](cornergas10000gauss.pdf){width="14cm"}

As the data does not show any hint of asymmetry, we assume an axisymmetric gas model. We first fit the data with a ring having a Gaussian radial profile as for the dust. Therefore, the surface density profile of the gas follows

$$\Sigma(R) = \Sigma_0  \exp\left(-\frac{(R-R_0)^2}{2\sigma_g^2}\right) ,$$

where $\Sigma_0$ is the surfaceorders of magnitude higher than the expected mass of $\sim 10^{-5}$ M$_\oplus$ without shielding. For this case, shielding from C$^0$ dominates over self-shielding. The shielding timescale becomes so long that the maximum CO mass that can be reached becomes dominated by viscous spreading, which is why the CO mass plateaus at $\dot{M}_{\rm CO} t_\nu \sim 0.8$ M$_\oplus$ (blue dash-dotted line). The C$^0$ mass does not reach its maximum theoretical value of $\dot{M}_{{\rm C}^0} t_\nu$ (orange dotted line) because CO spreads more rapidly than it is photodissociated and thus the maximum C$^0$ mass that can be reached is a factor $\sim t_\nu/t_{\rm COph}$ smaller. This also means that as CO spreads viscously, it is not necessarily colocated with the main dust belt (as was originally thought for gas discs


would increase the total number density up to $>10^4$ cm$^{-3}$. Hence, the gas is expected to be able to exchange angular momentum with the smallest dust grains in the system, therefore potentially leading to a radial displacement of these grains from their point of origin.

The exact interplay between the effect of gas drag and collisions is complex. Collisions will prevent grains from migrating too far (due to gas drag) as they may be destroyed before reaching their new steady state position, which needs to be modelled accurately. Here, we simply suggest that this gas drag may be able to explain the presence of narrow rings as observed with SPHERE in scattered light because small micron-sized grains will accumulate at the outer edge of the gas disc where itsC$^0$ in agreement with the observations.

We then refine the analytical model (see Sec. \[refined\]) and include self-shielding from CO as well as a time-dependence as C$^0$ takes time to accumulate, and we also take into account that the CO photodissociation timescale can become longer than the viscous timescale for shielded discs, meaning that CO will spread viscously before it has time to photodissociate. This refined model confirms our previous results and that $\alpha$ should be on the order of $10^{-3}$ to get a good fit of both CO, C$^0$ and the dust (as the CO input rate is set by the amount of dust in the system as more dust means more CO released). We also find that the C$^0$ mass required is compatible with that observed.

Finally, in Sec. \[allhyb\],


Q:

Bootstrap popover does not work

I want to toggle a popover when users hover their mouse in to a div. Is using popover with div possible or I am doing something wrong. My code:

 INTRO

Hover me

I also ut these in $(document).ready() function:
  $(function () {
    $('[data-toggle="popover"]').popover();
  });

My js script is in order and i do have bootstrap.css at top of my head tag

However, I think there is something wrong with my popover implementation. I failed even with just data-trigger = "focus". I created a pen on codepen.io: http://codepen.io/ngp130895/pen/qZQJOJ

A:

Basically it was not identifying to whichCompton made arrangements whereby J.M. would perform legal research for him. Attorney Compton forwarded a case file to J.M. at the Dodge Correctional institution without his client's prior knowledge or approval. J.M. performed legal research on this file for Attorney Compton. The referee specifically found that while J.M. was incarcerated, Attorney Compton did not have effective procedures in place to supervise J.M., to ensure that his conduct was compatible with Attorney Compton's professional obligations, or to ensure that J.M. would be able to maintain the confidentiality of the client matter while working from prison.
¶ 6 Upon J.M.'s release from prison in May 2002, Attorney Compton hired J.M. as a paralegal. From May 2002 to July 2002, J.M. worked on a number of case files for Attorney Compton. He


serum TLI concentrations >5 microg/L, ruling out EPI. No statistically significant difference was found in fecal elastase concentration among the 3 groups of dogs (P=.969). The results indicate that intestinal inflammation does not affect fecal elastase concentration, such that test results may be used to exclude a diagnosis of EPI even in animals with inflammatory bowel disease.he had been carried into an adjoining room and propped up on a table with his feet on two chairs, he was senseless, although there was still a faint pulse. When a surgeon arrived a few minutes later, the pulse had stopped, and Perceval was declared dead.

In the pandemonium that followed, Bellingham sat quietly on a bench as Perceval was carried into the Speaker's quarters. In the lobby, such was the confusion that, according to a witness, had Bellingham "walked quietly out into the street, he would have escaped, and the committer of the murder would never have been known". As it was, an official who had seen the shooting identified Bellingham, who was seized, disarmed, manhandled and searched. He remained calm, submitting to his captors without a


forms the foundation of its Google Assistant product, and the proficiency of its AI-trained translation algorithms is what has made Google Translate so staggeringly successful across so many different types of languages.

Of course, you won’t be able to develop sophisticated models and software like Google has without the proper expertise, resources, and sizable data sets. But the company is making it easier to start basic training of custom models with these new domains.

Already, Google says publishing giant Hearst is using AutoML Natural Language to help tag and organize content across its many magazines and the numerous domestic and international versions of those publications. Google also gave AutoML Translation to Japanese publisher Nikkei Group, which publishes and translates articles across a number of languages on a daily basis.

“AI isdoes not allow the court to assess costs against a state agency acting in its "adjudicative" capacity; and (3) this was not a proceeding for judicial review under sec. 227.485(6), Stats.
(1) Action by a State Agency. This is a nonissue because Sheely does not claim that she was the prevailing party in an action by a state agency. Actions by state agencies are included in sec. 814.245(3), Stats., because there are actions, for example, forfeiture actions, which are not preceded by a contested case hearing subject to sec. 227.485(3), Stats. The award of costs in this case was made pursuant to that portion of sec. 814.245(3) which applies to a "proceeding for judicial review under [sec.] 227.485(6)."
(2) Adjudicative Capacity. The WEAJA does not exempt state agencies acting in


Britain has experienced the hottest day of the year so far, and forecasters predict the heatwave will continue.

After a weekend of sunshine around the UK, temperatures in St James’s Park peaked at 29.4C (84.9F) on Monday, in line with sunny holiday hotspots in southern Spain. The pollen count and UV levels are also very high. The previous highest temperature recorded in the UK was 29.1C at St James’s Park on 19 April.

The Met Office issued a heatwave alert adding that there was an 80% chance of heatwave conditions between Tuesday morning and Thursday evening in parts of England.

UK weather: forecasters predict long hot summer Read more

Met Office (@metoffice) **HOT OFF THE PRESS** It's officially the UK's hottest day of the year so far, with 29.4 Celsius recorded atsymptoms and higher self-rated health status. Information technology use was not associated with depressive symptoms and self-rated health status. Investigation into reasons behind older cancer survivors' apparent low rates of engagement with ICT is warranted, particularly the examination of access as a potential barrier. Findings indicated that frequent use of communication technology was positively linked with mental and physical wellness. The nature of the relationships between communication technology use and physical and mental health merits further research, helping to determine whether community-based educational efforts to improve technology access and skills may benefit the growing population of older cancer survivors.


to the thread they
came from.

You can create custom local objects by subclassing the local class:

  >>> class MyLocal(local):
  ...     number = 2
  ...     initialized = False
  ...     def __init__(self, **kw):
  ...         if self.initialized:
  ...             raise SystemError('__init__ called too many times')
  ...         self.initialized = True
  ...         self.__dict__.update(kw)
  ...     def squared(self):
  ...         return self.number ** 2

This can be useful toof the tour. William Shakespeare is often mentioned in the north of Scotland because of Cawdor Castle – the Thane of Cawdor is in the play, Macbeth. Sueno’s Stone is a legacy of the Picts. It probably dates from 9thc and is superbly carved down one side. Nairn is a seaside resort on the southern shore of the Moray Firth and is popular as it is one of the driest and sunniest places in Scotland! Fort George is an outstanding artillery fortress built 18thc for the troops of King George II. It is impressive for its size and elaborate defences and it houses the Museum of the Queen’s Own Highlanders. Elgin sits in a rich agricultural area on the banks of the River Lossie. The ruins of the


13thc cathedral are still visible. The Grampian Mountains dominate the area and are usually snow covered in winter.

Private Tour Rates 2017/2018

Vehicle size

Duration/hours

Passengers

Rate

Car/Sedan

8 per day

up to 3

£600.00

MPV

8 per day

up to 6

£685.00

Large MPV

8 per day

up to 8

£685.00

Minibus

8 per day

up to 12

£ POA

This tour can only be done as part of an overnight tour from either Edinburgh or Glasgow. It cannot be done in one day. Rates are per car/minibus not per person and include your private Blue Badge qualified tourist guide, collection and return to your hotel (alternatives can be arranged), all taxes but not entrance fees to attractions where applicable, parking or meals unless stated. Guides overnight accommodation and meals £120 per night.that sanofi presented the results of the recently completed RIO-Europe study. FAC ¶ 46. Defendant Greene said, "I think at this point, we have looked at the database fairly closely and no concerns have arisen. And as you know, we're well along in amassing the entire [safety] database." FAC ¶ 46. Defendant Cluzel said, "On suicide, in fact, we have no signal. And if we have one signal, it is in placebo. So, no problem." FAC ¶ 46. Plaintiffs allege in their opposition memorandum to Defendants' motion to dismissbut not in the FACthat these statements became false and misleading when sanofi received the FDA's approvable letter on February 17, 2006. Plaintiffs contend that sanofi had a duty to correct, retract or otherwise update its prior statements about safety


deliberate illegal behavior. . . ." Novak, 216 F.3d at 308. Recklessness, on the other hand, exists where the conduct is *571 "highly unreasonable" and "represents an extreme departure from the standards of ordinary care" in light of the fact that "the danger was either known to the defendant or so obvious that the defendant must have been aware of it." Kalnit, 264 F.3d at 142 (quoting Carter-Wallace II, 220 F.3d at 39); Novak, 216 F.3d at 308. "[S]ecurities fraud claims typically have sufficed to state a claim based on recklessness when they have specifically alleged defendants' knowledge of facts or access to information contradicting their public statements." Id. (quoting Novak, 216 F.3d at 308).
The factual allegations in the FAC are sufficient to raise a strong inference thatcontrol of the primary violator by the defendant, and (3) that the defendant was, in some meaningful sense, a culpable participant in the controlled person's fraud," See ATSI Commc'ns, 493 F.3d at 108; SEC v. First Jersey Sec, Inc., 101 F.3d 1450, 1472 (2d Cir.1996). Here, Defendants challenge solely the pleading of the third element.
Plaintiffs' factual allegations are sufficient to sustain a section 20(a) claim against Defendants Le Fur and Spek. See Lapin v. Goldman Sachs Group. Inc., 506 F.Supp.2d 221, 246 (S.D.N.Y.2006) ("[I]n order to withstand a motion to dismiss, a section 20(a) claim must allege, at a minimum, particularized facts of the controlling person's conscious misbehavior or recklessness."); see, e.g., In re CIT Group Inc. Sec. Litig., 2010 WL 2365846, at *5, 2010 U.S. Dist. LEXIS


57467, at *15 (S.D.N.Y. June 10, 2010). Each of these Individual Defendants was a decision-making official who made an allegedly fraudulent statement about rimonabant. Each also had, as previously discussed, knowledge of or access to the omitted facts that allegedly rendered his statements misleading, and thus for the purposes of the pleading stage engaged in conduct that may constitute recklessness.
Plaintiffs' factual allegations, however, are insufficient with respect to the other individually named DefendantsDehecq, Cluzel, Lehner, Greene, and Leroy. None of these Individual Defendants are alleged to have made either of the statements that constitute actionable omissions. Plaintiffs fail to allege any particularized facts indicating that any of these Individual Defendants had "actual control" over the statements that were made, In re Alstom, 406 F.Supp.2d at 487 (citations omitted),of the rimonabant NDA in April 2005, the FDA had requested and Sanofi had produced additional patient records that showed a `signal' or possible causal relationship between rimonabant and suicidality. Based on that production of suicidality data and as a result of the FDA's concerns about the association between rimonabant and increased frequencies of suicidality, in February 2006 the agency required defendants to reassess the data from the clinical trials to investigate for other cases of suicidality." FAC ¶¶ 52(a), 59(a).
[12]  "The FDA required defendants to obtain an independent, formal assessment of the risk of suicidality from Dr. Posner's group at Columbia University in order to investigate the signal for suicidality detected during review of the NDA." FAC ¶¶ 52(b), 59(b).
[13]  "You know everything concerning rimonabant.


F.Supp.2d 146, 154 (S.D.N.Y.2004) ("It is not sufficient to allege, as plaintiffs have done in both cases addressed here, that it would have been possible to reach a different opinion than that reached by defendant based on information available to defendant at the time, or even that the defendant's opinion was unreasonable. A securities fraud action may not rest on allegations that amount to second-guesses of defendants' opinions about the future value of issuers' stock-second-guesses made all too easy with the benefit of hindsight.").
[22]  With respect to the October 27, 2006 statement and the December 5, 2006 statement, the omitted facts do not raise a conflict. FAC ¶¶ 59, 64, 74. The FDA's concerns and requests, as well as the results of Dr. Posner's assessment, are whollyadopted." "Have you found my Security Officer assigned to watch her?" "Why would the Hynerian be travelling alone?" "Perhaps, he wishes to become part of your... collection." "This is just a game to you, isn't it?" "On the contrary." "I care a great deal about one thing." "The knowledge of wormhole technologies the human Crichton holds locked in his memory." "Sirs." "This Hynerian royal was alone aboard the Leviathan transport." "You want the Leviathan,  the Leviathan gunship offspring, the other escaped prisoners, the defector Aeryn Sun, and especially you want the one called Crichton." "Well..." "I want my freedom." "Interested?" "They may not be on their way now,  but they will be coming." "If the Peacekeepers knew where we were, D'Argo, they'd be here already." "Look,


We were going to draw lots." " I did draw lots." "I lost." "Matter closed." " You are not the captain here." " No one is." "It is anarchy." "And today, it is my day to rule." " D'Argo, will you just..." " Listen to me!" "Time is short and so is my temper." "Fetch me some more kronite!" "D'Argo insists on flying this suicide mission, and says I have to stay behind and deal with Moya's offspring." "Well...he's right." "You are the only one of us that the baby trusts." " Have you selected a name for him yet?" " No." "Any suggestions?" "Christening a warship is out of my purview." "You know, you amaze me being a priest." "To live in such a violent world andyou or the Peacekeepers." " Crais, listen to me now." " You stop what you're doing and you leave the ship now!" "Officer Sun,  if by some..strange quirk, you survive your current situation,  and we manage to encounter each other again," "I hope that our relationship,  away from the Peacekeepers," " will be a much different one next time." " You cannot take a child from its mother!" "You forget it was done to me." "And it was done to you." "Goodbye, Officer Sun." "No!" "My Veen!" "The Command Carrier." " It's coming back." " Chiana is correct." "Peacekeeper Command Carrier is locked on to our position" " and is moving in." " You guys have got to get out of here." "Starburst now." "


Note-for-note transcriptions with tab of all of Nuno Bettencourt's guitar work on Extreme's highly successful second album. Includes the moving mega-hit More Than Words and a dozen more: Decadence Dance · Get the Funk Out · He-Man Woman Hater · Hole Hearted · It ('s a Monster) · Li'l Jack Horney · Money (In God We Trust) · Pornograffitti · Song for Love · Suzi (Wants Her All Day What?) · When I First Kissed You · When I'm President.new messages." "What's the worst thing that could happen, Zarah?" "So, Danielle, I have something." "Just a little something for you." "Oh, Nik." "You are spoiling me." "No." "I would like to spoil you more." "Hmm?" "Nik, Nik." "Good things..." "Good things come to those who wait, OK?" "How much longer are you gonna make me wait, huh?" "I'm just a poor little girl in a big bad forest." "I've got to look out for big bad wolves who want to eat me up." "You should be careful." "I will eat you." "Probably." "Maybe." "If you play your cards right." "Hey." "Thanks for tea." "Hey, angel face." "I got a big surprise for you." "A big surprise coming up." "Really?" "Yeah." "You will like." "I promise." "Goodnight, Nik."


thing." "This make me happy." "Hmm?" "And now  you make me... very happy." "Ow!" "Nik!" "Niki!" "Not yet." "No fucking "Not yet"." "Nyet to "Not yet"." "It is finished now - you tease my prick." "OK." "It's OK." "Just relax, hmm?" "Nik!" "Nik..." "Yeah, come on." "You will like." "Please." "Don't." "We're closed." "You couldn't squeeze me in, could you?" "I, uh, got all this hair in my eyes." "You seem sad." "I'm just thinking." "Can I make a suggestion?" "Shoot." "You're a good cutter, Danielle." "I mean, that's at least what I heard." "But, I mean, have you ever thought about managing a place like this?" "We've already got a manager." "Yeah." "But what if I want a new one?" "Hey?" "How about it, Danni?" "What?""Nik..." "Nobody!" "You are fucking hairdresser." "Woman!" "You're fucking nothing!" "Fucking WHORE!" "Ow!" "OK, good." "I hate your face." "Bottoms up." "Titties down." "Ah!" "You're bad." "Yeah." "I'm really, really bad." "Hey, Tiff." "Hey." "You know, after he's had a few, it's about this big, yeah?" "It's like a limp biscuit..." "Arggh!" "Ar-ar-ar!" "It's true." "That true?" "Look at you." "You're a poofter." "Hey, least I don't have to root goats." "Root what?" "Who's rooting goats?" "Get fucked." "Hey!" "Hey, hey, hey!" "Say sorry to her." "Hey." "Hey, play nicely." "We're only mucking around." "Fucking apologise!" "You alright?" "Huh?" "Yeah." "Everything alright?" "Yeah." "Did I hurt you?" "Nah." "Nah?" "Alright?" "Come on, man." "Happy?" "You wanna rumba, sexy?" "Mmm." "Hello?" "Hey?" "Roberta?" "Yeah, I'll be there in a


"Hey?" "His friend." "I only met him tonight." "Does this friend have a name?" "Benji." "Benji who?" "I don't know." "He seemed a real sweetie." "Aw." "Hey, yeah, it's OK, little bubba." "It's alright, Dhakota." "You do have a way with the girls, don't you, Benj?" "Yeah, I got a way with everybody." "Oh, hello." "Oh, she's so beautiful." "Oh, yeah." "There you go." "Aw." "Yeah." "There you go, bubba." "Did you hear about poor old PK?" "He was cut down in his fucking prime." "Tragic, eh?" "Yeah." "Yeah." "Yeah." "It's a tragedy." "Women who survive in the underworld have to have the gift of looking away and choosing what to see, what to hear, what to say." "They have to be wise monkeys - see no evil,hear no evil, speak no evil." "# Hide and seek is the game" "# We'll teach you how to play" "# Close your eyes" "# Really tight" "# Make it dark" "# Like the night" "# The party never ends" "# The game begins again" "# The party never ends" "# The game begins again" "# Climb the stairs to the top" "# Rooms are dark but don't stop" "# Getting close" "# Really warm" "# Now you're cold" "# On the floor... #"


he was when he was fully Tuatha Dé?

She couldn't believe that. She _wouldn't_ believe that. She _knew_ him. He was a good man.

 _Leap, Gabby,_ an inner voice whispered. _Tell him how you feel. Throw it all on the line._

She swallowed. Hard. Were Gwen and Chloe here, she knew they would echo that counsel. They'd taken such leaps, and look where it had gotten them. Who was to say it wouldn't work for her?

There was only one way to find out. Nothing risked, nothing gained.

She drew a deep, fortifying breath. _I love you,_ she whispered the words in her mind. She hadn't had a lot of practice with those words, had only ever said them to Gram, and long ago to parents, both of whom had gone away.very personal hatred of quitters, of people who just gave up and left.

It was something she could never permit herself to do.

So the very next morning after returning to the States, she'd gone in to work at Little & Staller, acting as if she'd never even been gone.

And just as she'd figured, no one had bothered to clean out her desk. Cases were still stacked every bit as high and haphazardly as ever they'd been. Cleaning it out would have taken time, and all the interns at Little & Staller were overworked. Besides, anyone foolish enough to clean off another person's desk inevitably got stuck with their caseload.

No, her desk would have sat untouched until one plaintiff or another had called, demanding to know why their case hadn't


statement asking the armed factions to leave the town?

Most people are very angry about the presence of security checkpoints and heavy weapons in the town.

This statement was issued with the goal of stopping all of the military activities that Jaish al-Islam and Failaq a-Rahman are carrying out inside Misraba. Because of the struggles, the area has turned into a military zone in every sense of the word. The streets are blocked and the town is surrounded by earthen berms and security checkpoints, some belonging to Jaish al-Islam and some to Failaq a-Rahman.

[Ed.: Longstanding tensions between Jaish al-Islam and Failaq a-Rahman—the two strongest factions in East Ghouta—exploded into nearly two weeks of infighting this past April. A mid-May deal between the groups stipulated that Misraba would become neutral territoryHeckles at wrist and ankle

Set this one up with a "sticky" wrist and ankle, then add small heckles as desired. The idea is to challenge your partner's balance to just the right degree. This is not a contest. Rather, the idea is to educate your partner's body for greater stability, responsiveness and physical intelligence. Plus, it's really fun. See exuberantanimal.com for more ideas about playful, functional training.


5, what is 10323443332 + 13?
10323443400
In base 3, what is 0 - -121010210011011?
121010210011011
In base 11, what is -98737 + 25a?
-98488
In base 8, what is -15 + 121274730?
121274713
In base 7, what is 2 - 323225316?
-323225314
In base 5, what is 10 - 30241320230?
-30241320220
In base 15, what is 2 + -8d671b6?
-8d671b4
In base 2, what is -101 - -11111010001000110010?
11111010001000101101
In base 2, what is 10 + 1111110001011101111010?
1111110001011101111100
In base 7, what is 11130620 - 21?
11130566
In base 7, what is 141 - -261322?
261463
In base 7, what is 0 - -6266414?
6266414
In base 13, what is -2b1783 + -57?
-2b180a
In base 15, what is 47e + -27b?
203
In base 11, what is 10 - -244213?
244223
In base 6, what is 5 + -41415310350?
-41415310341
In base 6, what is -231 + 3534140?
3533505
In base 4, what is -121030133 - -1313?
-121022220
In base 10, whatwith boiled or fried dumplingsOatmeal Porridge – served with milk and sugarLarge Jamaican Fruit Plate – served with toast

Breakfast Sides

Side of Fruit, Bacon, Home Fries, Ham, Fried Dumplings, One Egg, Toast

Beverages

LUNCH

Salads

Cobb Salad – Rows of jerk chicken and pork, shredded cheese, sliced egg, served atop a bed of fresh local greens with your choice of dressingVeggie Delight – A generous mix of vegetables and shredded cheesed on top of greens tossed with our own homemade mustard vinaigretteGrilled Chicken Salad – Slices of succulent chicken served atop a bed of fresh local greens with your choice of dressing

Soup

Daily selection of fresh-made soup

Sandwiches

Sandwiches are served with french fries.BLT – The American classic Bacon, Lettuce and Tomato served on toasted wheat bread with mayoJerk Club Sandwich – Sliced jerk chicken and


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exh. 1) The applicable law is Mass. Gen. Laws ch. 71 § 42, which states that "subject to the provisions of this section, the superintendent may dismiss any employee of the school district." Mass. Gen. Laws ch. 71 § 42. The section, in reference to non-teaching employees, does not mention either "at-will" or "for-cause." Id. The remainder of the section deals specifically with teachers, which is not applicable here, because the plaintiff was a non-teaching employee.
The Court finds that, after considering the contract as a whole, the plaintiffs termination required "just cause." The statute in question does not state that dismissal of a non-teaching employee requires "just cause" nor does it state that employment is at-will. It simply states that the superintendent has the authority to dismiss employees.once provides you the most savings

Units

PowerStore

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PowerMessenger

2

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3

~$960 ($320 each)

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4

~$1120 ($280 each)

~$280 ($70 each)

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5

~$1200 ($240 each)

~$300 ($60 each)

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6

~$1200 ($200 each)

~$300 ($50 each)

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Incremental Discount: Purchasing one at a time still gives you significant savings

Units

PowerStore

PowerGallery

PowerMessenger

2nd

~$360 (avg $380 each)

~$90 (avg $95 each)

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3rd

~$320 (avg $360 each)

~$80 (avg $85 each)

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4th

~$280 (avg $340 each)

~$70 (avg $80 each)

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5th

~$240 (avg $320 each)

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6th

~$200 (avg $300 each)

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our Government, including the Judiciary, as "department[s]," e. g., Mississippi v. Johnson, 4 Wall. 475, 500 (1867), that locution is not an ordinary one. Far more common is the use of "department" to refer to a component of the Executive Branch.
*700 As an initial matter, therefore, one might be tempted to conclude that § 1001 does not apply to falsehoods made during federal-court proceedings. This commonsense reading is bolstered by the statutory definitions of "department" and "agency" set forth at 18 U. S. C. § 6. First adopted in 1948, and applicable to all of Title 18, the definitions create a presumption in favor of the ordinary meaning of the terms at issue:
"The term `department' means one of the executive departments enumerated in section 1 [now § 101]of § 1001 was the original false claims statute, adopted as the Act of Mar. 2, 1863, ch. 67, 12 Stat. 696 (1863 Act). That enactment made it a criminal offense for any person, whether a civilian or a member of the military services, to
"present or cause to be presented for payment or approval to or by any person or officer in the civil or military service of the United States, any claim upon or against the Government of the United States, or any department or officer thereof, knowing such claim to be false, fictitious, or fraudulent."[7]*705 The 1863 Act also proscribed false statements, but the scope of that provision was far narrower than that of modern-day § 1001; the Act prohibited only those false statements made "for


of the lower federal courts. Indeed, in Illinois Brick Co. , we refused to follow a line of lower court decisions *720 which had carved out an exception from one of our precedents. 431 U. S., at 743-744.
But today's decision departs radically from the previously limited reliance on this exception. The principle of stare decisis is designed to promote stability and certainty in the law. While most often invoked to justify a court's refusal to reconsider its own decisions, itapplies a fortiori to enjoin lower courts to follow the decision of a higher court. This principle is so firmly established in our jurisprudence that no lower court would deliberately refuse to follow the decision of a higher court. But cases come in allshapes and varieties, and it isS. 339, 345-346 (1926). Bramblett could thus seemingly have been charged with violating § 287, or at least aiding and abetting in a violationof that statute, since his misrepresentation was intended to procure Government compensation. See Supplemental Memorandum for the United States in United States v. Bramblett, O. T. 1954, No. 159 (arguing that Bramblett's conviction could be affirmed because his conduct violated all the elements of § 287). In today's decision, we do not disturb the scope of § 287 as construed in either Cohn or Bramblett.

Bramblett's fraud also was arguably directed at an "agency" within the meaning of § 1001. The Court recognized this contention, noting "it might be argued, as the Government does, that the [Disbursing Office] is an `authority' within the § 6definition of


at 722, but the dissent can identify only five reported § 1001 cases in that time period brought in connection with falsestatements made tothe Judiciaryand Legislature. Post, at 723, n. (At leasttwo ofthe five were unsuccessful, fromthe Government's pointof view.) This tinyhandfulof prosecutionsdoes not,inour view, evidence a weighty reliance interest on the part of prosecutors in adhering to the interpretation of § 1001 set forth in Bramblett.
[*]   For false statements made to Bankruptcy Courts, see United States v. Taylor, 907 F. 2d 801 (CA8 1990) (upheld dismissal under exculpatory no doctrine); United States v. Rowland, 789 F. 2d 1169 (CA5) (affirmed conviction), cert. denied, 479 U. S. 964 (1986). For false statements made to Article III courts, see United States v. Masterpol, 940 F. 2dto pursue § 1001 count), cert. denied, 506 U. S. 1021 (1992); United States v. Hansen, 772 F. 2d 940 (CADC 1985) (affirmed conviction), cert. denied, 475 U. S. 1045 (1986); United States v. Diggs, 613 F. 2d 988 (CADC 1979) (affirmed conviction), cert. denied, 446 U. S. 982 (1980); United States v. Levine, 860 F. Supp. 880 (DC 1994) (denied motion to dismiss); United States v. Clarridge, 811 F. Supp. 697 (DC 1992) (denied motion to dismiss); United States v. North, 708 F. Supp. 380 (DC 1988) (denied motion to dismiss).


I have been looking forward to this book. As a maternal scholar with special interest in psychoanalysis, this is not only of interest to me, but also extremely helpful to my ongoing project of getting an thorough overview of the complex layers of “the maternal” as a theoretical question and a research area. The intersection between psychoanalysis, feminism, and motherhood is wide. In my experience, it tends to get wider as you study it. So I must admit I have high expectations for this book’s explanatory potential, especially since the table of contents include names like Nancy Chodorow, Alison Stone and Lisa Baraitser, just to name a few.

It is reassuring to see the interdisciplinary approach already in the subtitle. As Bueskens describes in the introduction, it is anUse a.empty, a.bool(), a.item(), a.any() or a.all().

any ideas how I can make this work?
Thanks!
CWE

A:

As @Wen said multiple where, not unlikely np.select
mask1 = df[col].shift() > 0.0
mask2 = ((df[col].shift() < 0.0) & (df[col] > df[col].shift())
mask3 = ((df[col].shift() < 0.0) & (df[col] < df[col].shift())

np.select([mask1, mask2, mask3],
          [df[col].pct_change(), abs(df[col].pct_change()),
           -df[col].pct_change()],
           0)

Much detail about select and where you can see here


Crash risk, crash exposure, and the built environment: A conceptual review.
This paper reviews the literature on the relationship between the built environment and roadway safety, with a focus on studies that analyse small geographical units, such as census tracts or travel analysis zones. We review different types of built environment measures to analyse if there are consistent relationships between such measures and crash frequency, finding that for many built environment variables there are mixed or contradictory correlations. We turn to the treatment of exposure, because built environment measures are often used, either explicitly or implicitly, as measures of exposure. We find that because exposure is often not adequately controlled for, correlations between built environment features and crash rates could be due to either higher levels of exposure orthe exposure for following factors: male gender, smoker status, vascular family records, obesity assessed through body mass index > 30 kg/m2, age > 45 years in male, age > 55 years in female (p < 0.05). The ischemic heart disease was significant associated only with family records and age > 55 years in female. Most of these cases diagnosed in the occupational diseases clinic represent active workforce (47.96 +/- 8.82 years). Early diagnosis of cardiovascular diseases in connection with risk factors may prevent a premature death, affecting workforce, with medical and socio-economical consequences. Cooperation between general practitioner-occupational diseases specialist-cardiologist may improve the efficiency of prevention programs.


our devotion and desire to keep trying to walk right before Him.

God Looks for Devotion

We all admire King David as the man whom the Lord Himself described as “a man after [His] own heart” (Acts 13:22), but his life was far from perfect! He had committed adultery and murder, and conducted a national census in disobedience to God.

I remember being struck by what God said about David’s heart being fully devoted to Him (1 Kings 11:4) and how “My servant David. . . kept My commands and followed Me with all his heart, doing only what was right in My eyes” (1 Kings 14:8).

Seriously? Even after all David had done?

It occurred to me in that moment that God sees perfection very much differently from how I see it.Father of the heavenly lights (James 1:17) gives me grace to keep walking better in the light.

Therefore, I can say with the Apostle Paul, “I do not consider myself yet to have taken hold of it. But one thing I do: Forgetting what is behind and straining toward what is ahead, I press on toward the goal to win the prize for which God has called me heavenward in Christ Jesus” (Philippians 3:13-14).

So I no longer identify with the line by Mary Oliver. Sure, there are some days when I still struggle with trying not to counteract my shame and guilt issues with perfectionism. But as I grow in this journey, I am now more able to say: Every morning, I wake with thirst for God, who is


generosity, kindness, patriotism, contribution to national development and his undying willingness to always help others develop in life.

The late Moseray Fadika, who was the 2013 Africa Entrepreneur, was also appointed as the first Goodwill and Business Ambassador for the Commonwealth Africa Initiative. The appointment was announced at the Commonwealth Africa Summit held in London in March 2016.

The Summit which led to his appointment brought together world leaders and personalities from across the fifty-three Commonwealth countries, including Presidents, former Presidents, Ministers, High Commissioners, Members of Parliaments, policy makers, representatives of the private sector, civil society, Diaspora organizations, youth groups, Commonwealth agencies, academia, celebrities and the media.sports ST. PAUL (AP) — The idea of seat licenses is a key financing mechanism for a number of sports stadiums, and some experts predict it will become part of the mix in the debate over a new stadium for the Minnesota Vikings. Under the arrangement, fans would buy their seat from the team and pay for...
Brainerd, 56401

Brainerd MN 506 James St. / PO Box 974 56401

2011-12-05 20:51:55

ST. PAUL (AP) — The idea of seat licenses is a key financing mechanism for a number of sports stadiums, and some experts predict it will become part of the mix in the debate over a new stadium for the Minnesota Vikings.

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Under the arrangement, fans would buy their seat from the team and pay for game tickets separately. In return, teams


The Twins won’t disclose the proceeds, but Vikings officials estimate the team made about $5 million.

That’s not much by NFL standards. Based on the NFL average for seat license revenue in the last five stadiums, Vikings fans could put up as much as $240 million dollars for the new stadium, MPR reported, adding that the money probably would count toward the Vikings’ contribution, which would be on top of any public subsidy.

Vikings fans like P.J. Wiggan are already wary. The Fridley social studies teacher has had season tickets at the Metrodome for more than a decade, but he’s not ready to ante up for a new stadium given the team’s poor post-season record.

“If I looked at it as an investment opportunity, I could maybe start to justify it,”Introduction {#s1}
============

Global climate change is predicted to increase the Earth's mean annual temperature by 2--4°C in the next decades [@pone.0067093-ACIA1], [@pone.0067093-Hansen1] and influence the frequency of weather extremes, such as severe storms and droughts. The resulting impacts on animal populations are likely to be significant at both regional and global scales [@pone.0067093-Parmesan1], [@pone.0067093-Anders1], [@pone.0067093-Both1], [@pone.0067093-Jonzen1], [@pone.0067093-Gordo1], [@pone.0067093-Both2], [@pone.0067093-Jiguet1].

In several migratory bird species, the timing of spring migration and subsequent initiation of breeding have been shown to occur progressively earlier in response to weather changes [@pone.0067093-Jonzen1], [@pone.0067093-Gordo1], [@pone.0067093-Marra1], [@pone.0067093-Gunnarsson1]. Among long-lived seabirds, changes in local weather conditions have also been shown to influence nest initiation dates [@pone.0067093-Moe1] and the subsequent timing of prey availability for nestlings [@pone.0067093-Watanuki1], chick growth and fledging rates [@pone.0067093-Thompson1], [@pone.0067093-Gjerdrum1] and adult survival rates [@pone.0067093-Grosbois1].


is 300.000 pairs, with a wintering population of 847,000 (566,000--1,127,000, 95% confidence limits) individuals [@pone.0067093-Institute1], [@pone.0067093-Gardarsson1]. Nest initiation begins 1 May at the earliest but the last nests are initiated in mid-June. Clutch size generally is 3--5 eggs which is similar to that in other populations [@pone.0067093-Jnsson1], [@pone.0067093-Jnsson3], [@pone.0067093-Kristjnsson1], [@pone.0067093-Coulson1], [@pone.0067093-Robertson1], [@pone.0067093-Erikstad1]. Earlier nesting is related to increased clutch sizes [@pone.0067093-Jnsson1], [@pone.0067093-Lehikoinen1], [@pone.0067093-Mehlum1]. In Iceland, male eiders remain with females by their nests into mid-incubation, unlike that reported for other populations [@pone.0067093-Iles2]. Many common eider colonies have been husbanded for eider down collection since before the 19th century, often maintained by the same families who have kept records of numbers of nests throughout the 20th century.

Data Collection {#s2c}
---------------

We collated data on the number of nests per year (hereafterlocal weather data (temperature, precipitation, atmospheric pressure and wind speed) were averaged for each season (winter: December-March; spring: April-May; summer: June-September; autumn: October-November) and then indexed using a principal components analysis (PCA). The PCA not only reduced number of variables within each season but, more importantly, accounted for combined effects and interplay of weather variables within each season [@pone.0067093-Jnsson1], [@pone.0067093-Jnsson2], [@pone.0067093-Traylor1]. PC scores that explained ≥25% of the variation in the four weather variables were included in subsequent correlations with eider demography.

We used the weather station in Stykkishólmur, West Iceland, which is representative for all of Iceland [@pone.0067093-Einarsson1], [@pone.0067093-Jnsson5] and most of our data (11 of 17 colonies) come from nearby colonies in the bay of Breiðafjörður, West Iceland ([Fig. S1](#pone.0067093.s001){ref-type="supplementary-material"}). However, we also examined relationships using weather


Such a relationship should not be observed for any colony unless the number of breeding females is somewhat dependent on recruitment.

Duckling mortality is probably relatively more important than hatching failure in limiting breeding success prior to fledging in common eider [@pone.0067093-Swennen2]. Furthermore, females remain faithful to their natal colony and males pair with females from their natal colony more often than would be expected at random [@pone.0067093-Swennen1], [@pone.0067093-Tiedemann1]. Thus, colony-specific production will partly determine recruitment to a given colony because both sexes display philopatry, although males do so to a lesser extent or not at all [@pone.0067093-Tiedemann1], [@pone.0067093-Swennen2].

In Flatey, drier summers were positively related to breeding numbers three years later. At Þyrill and Hrísey, warmer, calmer summers were negatively related to breeding numbers three years later. In Scotland,Friday Travel Photo: Jaipur, India

Our “Friday Travel Photo” comes from member Cristina Cardenal of Miami. Cardenal visited India in July for two weeks with her family, and said it was an amazing time of many firsts. “When the tour guide said we would be entering Jaipur’s Amber Fort in the traditional way, I thought he was referring to an entrance used by the maharajah,” she says. “I was not expecting an elephant ride. The closest I had ever been to an elephant was at the zoo and even though the mahout — the elephant driver — assured me that I’d be fine, I was panicked the whole way up to the fort. Once safely on firm land, we explored the Amber Fort and looked at the regal city


2:

Cut into light bulb shapes (light bulb cutter available on Amazon or you can cut them by hand with a knife like I did!). Create a small hole at the bottom of the bulb with a toothpick, spinning the toothpick to ensure the hole is large enough to pass a small wire through it.

STEP 3:

Bake on ungreased cookie sheet at 350 degrees for 8-10 minutes or just until beginning to turn brown around the edges. (Top tip: If you are having a problem with your cookies holding their shape, it helps a lot if you put them in the freezer on the baking sheet for about 15 minutes before you bake them.) Then leave to cool.

STEP 4:

Beat your powdered sugar, meringue powder & warm water for 4-5 minutes,Flap ureteroplasty for segmental structure of middle third of ureter.
A technique is described for repair of segmental stricture of the middle third of the ureter utilizing spiral or vertical flap from the proximal dilated ureter. In all cases a 10 F polyethylene ureteric stent with a ureterotomy exit 5 cm. distal to the repair site was used. Twenty-eight ureters in 27 patients were repaired by this technique, with good results in all except 3 cases which showed postoperative residual dilatation three months after surgery.


the gem index
download with that, and save the need for server CPU cycles?

~~~
qrush
I'd love to have git be a part of the solution here, really, any other
solution would be awesome. Hit me up in #rubygems on IRC or email me (nick
[at] quaran.to) and we can talk about it :)

------
icepick
Does ruby's Marshal have the same problems that python's pickle have? Could
you construct a valid Marshal bitsting that when loaded would run malicious
code? Is this exposing folks to a MITM attack on rubygems?

~~~
moeffju
What about the old Marshal problems? I just played with Marshal on my rails
console again and it seems it still encapsulates all sorts of implementation
details. I haven't tried whether it's now compatible across Ruby versions, but
I recall the Marshal format changed a few times, introducing incompatibility.

tl;dr: Why, oh     'value'     => date( 'd.m.Y', time() ),
            'type'      => 'numeric',
            'compare'   => '>='
        )
    )
);
new WP_Query( $args );

Unfortunately, the query does not yield reliable results. I can not even say 100% why. On some days all offers appear, on other days there are no offers.
I have also tried to find out the cause of the problem in the Codex, but it seems I am a strong blockhead.

A:

This below solution may be handy to someone
$args = array(
'cat' => $cat_ID,
'meta_query' => array(


“I’m wondering if Alien 3 is in the typewriter?” Bobby Wygant asked James Cameron upon the release of Aliens in 1986. “Not for me it’s not,” he answered.

“I think Fox will want to see how this film does,” Cameron continued, “and if they’re still enthusiastic about, or if they become enthusiastic about a continuation beyond the film that Gale and I made then they’ll have to pursue that in their way. I mean find a writer, find a director, because we’ll be on to something else, I think. Some new territory.”

“But if the money were right?” Wygan teased. “No, I don’t think so,” he answered. “At this point, y’know, the way I work on films and the way my wife -who produced this film- works, is we throw0.2 and 0.25 ng/mL. Intra- and inter-assay precision and accuracy did not exceed 15%, in accordance with bioanalytical validation guidelines. The described analytical method was proven to be robust and was successfully applied to the determination of fentanyl in plasma and CSF samples from a pharmacokinetic and pharmacodynamic study in newborn piglets receiving intravenous fentanyl (5 µg/kg bolus immediately followed by a 90-min infusion of 3 µg/kg/h).


multiple light-switchable protein ligands to the cell membrane without any optimization of the non-ligand protein parts. Consequently, we explored whether the lumitoxin architecture fulfills this requirement by creating lumitoxin genes containing different peptide toxins that target distinct Kv channel types. Whereas αDTX blocks both Kv1.1 and Kv1.2 channels^[@R28]^, *Dendroaspis polylepis* DTX-K, which shares only 63% sequence identity with αDTX, blocks mainly Kv1.1 channels^[@R29]^. Conkunitzin-1 (CONK1), isolated from the marine cone snail *Conus striatus*, specifically blocks the Drosophila Shaker Kv channel^[@R30]^. We expressed the resulting lumitoxins in mammalian cell culture co-transfected with with the Kv channels Kv1.1, Kv1.2 and Shaker. We used a variant of the Shaker Kv containing a mutation (K427D) shown to increases CONK1 affinity^[@R30]^. Whole cell patch clamp electrophysiology reveals a clear specificity in the abilityBioscience). Adherent cells were transfected using Lipofectamime LTX (Invitrogen) following manufacturer's instructions and recorded 36--48 hours later.

For confocal microscopy, cell were fixed with 4% formaldehyde, permeabilized with 0.4% saponin, and either stained with anti-FLAG M2 peptide antibody (Sigma A2220, 1:1000 dilution) followed by anti-mouse-Alexa488 secondary antibody staining (Invitrogen), or directly observed using mCherry fluorescence.

Electrophysiology and illumination {#S12}
----------------------------------

K^+^ currents were recorded from PC12 cells 36--48 posttransfection using whole cell voltage clamp. Analog signal were filtered (1--5kHz) using the built-in 4-pole Bessel filter of an Axopatch 200B patch clamp amplifier (Molecular Devices), digitized at 10kHz (Digidata 1440A, Molecular Devices) and stored on a computer harddisk. The bath solution contained (mM): 125 NaCl, 2 KCl, 3 CaCl~2~, 1 MgCl~2~, 10 HEPES, 30 glucose, adjusted to pH 7.3 with NaOH. Electrodes were


staff are extremely courteous. But please understand this is a budget hotel and do not expect the trappings of 5-star luxury.
Check-in is quite quick and the rooms are also pretty good, though a little congested with all the heavy furniture inside. Bathrooms...
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Dear Guest,
Thank you for sharing your experience on Tripadvisor. We are happy to know that you have given positive feedback for room, food and staff attitude. Based on your comments necessary changes have been made to fix the TV channel and bathroom leakage issue. We are sorry for the inconvenience caused. We are looking forward to welcoming you next...
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FreeS2 cells were co-transfected with BirA and one of the BLRP tagged versions of Fru (FruA, FruB or FruC; [Figure 1A](#f1){ref-type="fig"}). Streptavidin coupled to magnetic beads was used to immunoprecipitate the tagged, biotinylated Fru protein isoforms. To confirm both the expression, the tagging of the protein and to validate the pull down technique, the immunoprecipitated samples were detected via western blotting using an antibody specific for the male specific epitope (FruM)[@b9] ([Supp Figure 1](#s1){ref-type="supplementary-material"}). Chromatin Immunoprecipitation coupled to high throughput sequencing (ChIP-Seq) was performed as described, in order to identify the direct regulatory targets of each of the Fru isoforms in this model system. Peaks of enrichment, indicative of Fru binding, were identified via the Model-based Analysis of ChIP-Seq (MACS) program[@b30]. Using a p-value cutoff of p \<


libraries with fragment size approx. 300--700 bp and quantified using the Agilent Bioanalyser. Cluster generation and sequencing was carried out via Illumina/Solexa Genome Analyser (GA) II according to the manufacturer\'s protocols.

ChIP-Seq data analysis
----------------------

After quality filtering, sequence reads (between 20--22 million unique reads per sample) were mapped to the *Drosophila melanogaster* genome (2006 assembly; BDGP Release5/dm3) using Bowtie (version 0.12.2) and visualized using the integrated genome browser (IGB). Peak finding was performed using MACS version 1.3.6.1[@b30] using the default parameters and the settings: \--tsize = 25, \--bw = 300, \--mfold = 32, \--pvalue = 1e-10 for the ChIP-Seq replicates vs input. The proximity of peaks to genes was determined using the galaxy bioinformatics server (<http://galaxyproject.org/>)[@b39].

Gene Ontology and protein domain enrichment
-------------------------------------------

Gene Ontology (GO) and protein domain enrichment were carried out fortranscript enrichment in the cell sorted samples. Significant enrichment of both *Dop2R* and *Dscam3* transcripts was observed in Fru positive neurons compared to baseline (Fru negative neurons), suggesting that Fru acts to upregulate the expression of these genes. Results are representative of two independent biological replicates. Significance was calculated using students t-test where \* = p \< 0.05 and \*\* = p \< 0.01.](srep04412-f3){#f3}

![ChIP-Seq identified genes demonstrate expression changes in the male fly brain.\
The genes identified in this study via ChIP-Seq were compared to a recent RNA-Seq study[@b25] that assessed gene expression changes in the male fly brain following overexpression of each of the male specific isoforms FruA, FruB and FruC. A highly significant degree of overlap was observed between these datasets. Approximately one quarter of the genes


independent association between the different variables and SDI scores at TL. Seventy-two Hispanics, 104 African Americans, and 82 Caucasians were included. One-half of patients had not accrued any damage. Caucasians had the lowest SDI scores at T0, and Hispanics had the highest scores at TL. Renal damage occurred more frequently among Hispanics and African Americans, while integument damage was more frequent among African Americans. Neuropsychiatric (20%), renal (16%), and ocular (15%) damage occurred most frequently among all patients. Independent predictors of SDI at TL were age, corticosteroid use (maximum dose at T0), number of American College of Rheumatology (ACR) criteria met, disease activity, and abnormal illness-related behaviors. Other variables were less consistently associated with damage accrual (poverty in African Americans, lack of HLA-DRB1*0301 in Hispanics, presence of HLA-DQB1*0201Women’s Rights Advancement and Protection Alternative (WRAPA)

You can help

We can build on hope

With these girls, we have seen hope, we can build on hope… with those of them that have come back, there is work to be done. How much work? I can’t tell you. It’s so much work to reconstruct the psyche of someone who has been through what these girls have been.

These are the words of Saudatu Mahdi, Secretary-General of Women’s Rights Advancement and Protection Alternative (WRAPA) and a co-founder of the Bring Back Our Girls campaign, at a Donor Direct Action event in New York earlier this month. The event brought together Jane Fonda, Gloria Steinem, Robin Morgan and was moderated by ABC’s Amy Robach. Saudatu talked about the need for us to stay hopeful


a special treatment for that key, and they will actually generate an image file themselves in some folder (typically under My Documents or AppData).
If you run a game with the Steam overlay on it (whether a real Steam game or just an external game launched through Steam), Steam has a special mechanism for taking screenshots, which saves the images to a special location and allows you to easily upload them online to the Steam cloud. The default key for taking Steam screenshots is  F12,

A:

I agree with Oak that Steam is a very viable option for taking screenshots in-game as well as the stock print screen mechanic.
I would like to pose a third option, though. You could always check out a utility like Greenshot. Which takes thethe higher-numbered function keys (e.g. F11 or F12), but as Oak said, some use the obvious choice of PrtScr.
Windows
In addition, for many games, Windows own PrtScr handler will suffice. If it doesn’t work in fullscreen, often, but not always, switching to windowed mode (if the game supports it) will allow it to work.
Technical Explanation
When PrtScr doesn’t work for a fullscreen game (or sometimes even a windowed game), it is because the game is using the video-adapter’s hardware overlay [1] [2][3] (not to be confused with software overlays like those of Steam, Fraps, etc.) This is a special buffer (surface for DirectX games) that software can write to which provides hardware acceleration. By nature, it is just a simple (usually near-black) rectangle that the video-adapter fills in with the


clears your clogs and cleans your lines without damage. Hydro jetting is a safer solution as opposed to utilizing metal snakes.

Inspections

Statewide Environment Services LLC performs NJDEP-guided inspections. Septic system inspections are done in connection with the sale or purchase of a home and also can be done to locate components. An on-lot wastewater system inspection can bring to your attention any potential issues before malfunction.to stop.

Can we set that side for a minute, just so you can feel what I’m saying?

I’ve been burned before, publicly. I’m just as scared to open myself up to you, as you are to me. Some extroverts present as shy and don’t even realize that they are, in fact, extroverts. Because somehow we’re not allowed to feel insecure.

Myth 3. Extroverts aren’t introspective.

A common argument is that introverts think and extroverts act.

As my counter-argument, I present this entire blog.

Myth 4. Extroverts don’t want to hear what you have to say.

Nothing could be further from the truth! I’m intensely interested in other people. That’s kind of the definition of extroversion. I get high off being around you.

But I do understand the source of the confusion — and it’s something


color are building the future of the U.S. labor movement. They are imagining—and implementing—successful alternative organizing strategies for low-wage sectors that are transforming the labor movement as a whole.

A key example of this is found in the domestic workers’ movement, a movement of nannies, housekeepers, and caregivers working together to codify basic labor protections for their historically unregulated sector. The National Domestic Workers Alliance is comprised of approximately 53 workers center affiliates throughout the country, including the Chicago Coalition of Household Workers, Mujeres Unidas y Activas in California, and the Brazilian Worker Center in Massachusetts.

Critically, many of these organizations were founded and are led by women of color. Many of these leaders have been domestic workers themselves or are the children of domestic workers. Priscilla Gonzalez led the[The relationship between dental graduate students' MBTI types and academic achievement in problem-based learning].
The study aimed to determine the personality types of the graduate students in Seoul National University School of Dentistry (SNU SD) and analyze the specific personal types that were linked to their performance in problem-based learning (PBL). A total of 263 graduate students in SNU SD from 2011 to 2013, participated in PBL and completed the Myers-Briggs Type Indicator (MBTI) GS form, which was analyzed statistically to determine whether their MBTI personality types were independent of their PBL performance. In particular, MBTI types were regressed on evaluation subcategories, including tutor evaluation and oral test. ESTJ (20.9%) and ISTJ (18.6%) were the most common MBTI personality types in dental graduate students. Compared with males, female students


Centerville, Ohio (disambiguation)

Centerville, Ohio is a city in Montgomery and Greene Counties in the U.S. state of Ohio.

Centerville, Ohio may also refer to:
Centerville, Belmont County, Ohio
Centerville, Clinton County, Ohio or Lees Creek
Centerville, Gallia County, Ohio
Centerville, Marion County, Ohio
Centerville, Wayne County, Ohio

See also
Center Village, Ohioworst kind of holiday surprise for Utahns, who normally get flooding during late-spring snowmelt and late-summer monsoons rather than on the winter solstice.

The rain even made it to Colorado's mountains, where the ski town of Aspen got a day's worth of liquid in place of the champagne powder that's far more common around the holidays.

One of the best depictions we've found of La Niña influences on North American weather during the northern winter. (Courtesy NOAA.)

La Niña throws a curve ball

Not only are some of these rains setting records—they’re falling in places where this winter was expected to be on the dry side. When a moderately strong La Niña is under way, as is now the case, the odds are boosted for a wet winter across the Pacific Northwest,


while conditions tend to be drier than usual from southern California across to the southern Rockies. The separation zone lies close to 40°N latitude, roughly from San Francisco to Denver, though it can vary as the winter unfolds. See this very cool animation from AgroClimate, a university consortium.

Why did this week’s heavy rain and snow take an unusual path? A huge center of high pressure in the northeast Pacific pushed the jet stream’s trajectory southward, notes NCAR’s Kevin Trenberth in an interview with San Francisco’s KQED. Such features are part of weather’s natural variability, Trenberth adds, although global warming tends to make wet systems even wetter.

This graphic from a NOAA “box and whiskers” analysis for climate division 93 in southern California (see map) shows how rainfall during LaGate valves are typically used when a straight-line flow of fluid and minimum flow restriction are required. They may also be used in christmas trees used for oil and gas extraction. Typically, the gate has body with a cavity and a flow passage extending through the body and intersecting the cavity to allow flow through the valve. When the valve is wide open, the gate is drawn into an end of the valve cavity away from the flow passage. The flow passage is typically the same size as the pipe in which the valve is installed.
A typical gate valve used in connection with oil and gas production has a flow passage that intersects a central cavity in the valve. Seat rings are placed in counterbores formed in the


has temperature limits that prevent use at the highest temperatures seen in oil and gas fields. To counter this problem, a Teflon-type elastomeric seal has been used. The seal is pressure actuated to seal when in the downstream seal position and loaded from the direction of the valve cavity, as shown in FIG. 1. When in the upstream seat position, the pressure load from the pipe direction tends to collapse the seal at a relatively low pressure once the seal is overcome. A T-shaped insert prevents that collapse from resulting in damage to the spring. However, this configuration does not address the wear associated with elastomeric seals.
A need exists for a technique to increase life of seals in gate valves by reducing wear in the seat seal.circle with lintel stones on top of which only some are still standing. The standing stones weigh about 25 tonnes and are 4mts high and are thought to have come from 40km (25miles) away. The smaller (still weighing 5tonnes) more precious ‘bluestones’ that were used are thought to have come from Wales 250km (170miles) away! What impressed me the most was that the lintels are secured using the woodwork ‘tongue and groove’ method. These massive stones were cut out and then placed exactly on each other is some achievement today never mind thousands of years ago. Stonehenge is thought to be the finishing point of a ritual journey for burying the dead which is among a huge number of theories about inter-tribal cooperation, healing powers of the stones


close to it is beyond me, whatever about the back road. A new visitors centre has just opened so now you must head there and take the bus in order to visit the site and find out what is Stonehenge.

Despite it being just another bunch of stones, it is definitely worth a visit so you know what the fanfare is about and try and think yourself with all your education how would YOU move a 30tonne rock with no machines??

Practicalities – What is Stonehenge?

€1 = £0.85 pound, $1 = £0.64

Language – English is the first language and almost no other language is spoken. At Stonehenge tours can be taken in several languages

Price and Opening Times – ADVANCED BOOKING IS REQUIRED FROM FEB 2014 ONWARDS. Tickets will be timedlives, learn to trust His leadership and do what He instructs us to do. He is a Comforter sent by God to help us. For Him to help us, it requires our ears, our hearts, our trust and our obedience. Anything short of this will produce inferior results, results far short of the supernatural life you really desire: He is there to help you, so let Him help you.

Source: The Dynamic Duo by Rick Renner Excerpt permission granted by Creation House

Author Biography

Rick and Denise met while they were each on an individual quest to wholeheartedly follow Godâ€™s plan for their lives. Rick was a college student, growing in his teaching ministry. Denise was a talented vocalist. She chose not to pursue a course that held the prospect of


say in the current government.

"She evidently had an influence on the appointment of various governors," Meuser said. "In Ukraine those aren't such important positions because the governors are appointed by the government in Kyiv. Some were chosen from the center and east of the country, and can effectively be considered her fellow party members."

Winning voters' trust

But despite being seen as an icon in the West, Tymoshenko is regarded by many in Ukraine as an extremely controversial figure.

"There is a lot of mistrust towards her," Steffen Halling, a Ukraine expert at the German Institute for International and Security Affairs (SWP), said of the popular mood in Ukraine.

Tymoshenko earned a lot of money in the 1990s with her gas business, which some critics have described as shady. Should the crisisQ:

Request for MageStackDay IV: Tag Cleanup

Hi, it's me, the tag janitor.
As the next MageStackDay is coming, I'd love to see a new section next to voting, answering and closing: tag cleanup.
IMHO the site has a problem with overspecific and redundant tags, so it's hard to find the "right" tags for a question and also hard to find questions to answer by tag (without following hundreds of useless tags).
So my proposal is to hunt down overspecific tags and create synonyms:

This way, these tags are still in the system and if somebody wants to use them, they automatically get changed to the master tag of the synonym.
What's overly specific?
The number of questions per tag is a good indicator, but should not be the only criterion because with Magento 2, new


and trailers incorporating a gooseneck hitch can only be connected to a tow vehicle that has an appropriately configured ball hitch. This limitation often creates problems in situations where it is desirable to use the same vehicle to tow multiple trailers incorporating different hitch arrangements. For example, if the tow vehicle has a 5th wheel hitch and the trailer to be towed has a gooseneck connector, the user would be required to proceed with the time consuming task of removing and replacing the 5th wheel hitch with a gooseneck ball hitch. Not only is this process time consuming, but it also results in the added expense of having two different types of hitches on hand.
In an attempt to overcome some of the problems associated with having multiple trailersher "brother") was the catalyst for her to search for her biological father. After dating Finn, she discovers that music is her passion, and starts a band called Indigo Skye. Lynn is often considered the bohemian of the group, with her carefree nature and down-to-earth personality, and is a vegan. By Season 8, she had signed with "Dirty Girl" Records.

 Antoinette "Toni" Marie Childs-Garrett (played by Jill Marie Jones, Seasons 1–6) has been Joan's friend since childhood, they attended elementary, high school and college together. Toni grew up in a poor farm family with an alcoholic mother in Fresno, California. Toni is considered the selfish and popular one of her girlfriends and is the self-proclaimed "cute one" of the group. During the first season she despised Maya (whom


the altar, he eloped with Lynn on a whim; he realized that he wanted to find true love and they ultimately divorce. He later realizes that Joan is the right woman for him, but after three months of courting, the two end their relationship. He became a sperm donor for his sister Linda and her same-sex partner, and regards the baby as his "nephew-son." He is also co-owner of the J-Spot restaurant with Joan. In later seasons, William forges a tight bond with Darnell. During Season 7, he was working on his marriage with Monica. According to his mother, his middle name is spelled with two "R"s, and a silent "W".

 Monica Charles Brooks-Dent (played by Keesha Sharp, Seasons 7–8, main; 3–6, recurring) is William's wife. All fourXander
 Reverend Al Sharpton; Himself
 Richard T. Jones; Aaron
 Rockmond Dunbar; Jalen
 Rhonda Ross Kendrick; Laurie (Halloween party guest)
 Sandra Bernhard; Marcia
 Saul Williams; Sivad
 Shar Jackson; Niecy
 Shawn Harrison; Peaches
 Sinbad; Himself
 Steven Cojocaru; Taz
 Suzanne de Passe; Herself
 Tasha Smith; Shandara Duranni
 Terrell Davis; Himself
 Terri J. Vaughn; Tasha
 Tia Mowry; Melanie Barnett
 Traci Bingham; Candy
 Tracy Vilar; GiGi
 Tricky; Finn
 Una Damon; Myoshi
 Wayne Brady; Derek Tyler
 Wendy Raquel Robinson; Tasha Mack
 Wendell Pierce; Anthony Jackson

Awards

Spin-off

A 2006 episode of Girlfriends entitled "The Game" featured guest star Tia Mowry as Joan's cousin Melanie Barnett, an aspiring medical student, who wants to give up her


receives a placental transfusion. Several important clinical trials in both term and preterm infants will help answer the question as to its clinical benefit. There are a number of logistical issues that will need to be improved before this becomes standard practice, but it holds tremendous promise.

This research received no external funding.

The authors declare no conflict of interest.

![Preterm infant without spontaneous respirations.](children-06-00060-g001){#children-06-00060-f001}

children-06-00060-t001_Table 1

######

Completed trials of neonatal resuscitation with an intact cord.

  Study                                                *n*   GA (weeks)  Mairead get separated from the others. A small boy named Ravi offers to be their tour guide. Ravi is part of the untouchable caste and is an orphan after his mother died. Ravi shows them around, exchanges their money. The girls are sticking out so Ravi uses their money to buy them Indian clothing. He shows them the different Indian gods, including the Goddess Kali and the God Ganesh. After the girls eat some Indian food they are able to ride an elephant. Riding the elephant, Jacky and Mairead go on to be part of a procession through town, where at the end, in the Governor's box, sit Captain Laughton and Higgins. Jacky decides to joke around. While on the elephant, Jacky stands in front of Mairead and


King and has been sentenced to seven years in Australia.
John Higgins: Jacky's assistant, he joins the Lorelei Lee as the Purser's assistant so he can be close to Jacky.
Mairead Delaney McConnaughy: Jacky's friend and wife to Ian McConnaughy. She is also sent to Australia.
Captain Laughton: The Captain of the "Lorelei Lee".

Category:2010 American novels
Category:Children's historical novels
Category:Pirate books
Category:American historical novels
Category:American children's novels
Category:2010 children's booksqubit 3 shows that the time-optimal synthesis of the $\mathrm{CNOT}^{\pm}(1, 3)$ (which acts as the identity when the control qubit 1 is in the state ${|{0}\rangle}$, while if the control qubit is in the state ${|{1}\rangle}$ the target qubit 3 is flipped as ${|{\pm}\rangle}\rightarrow {|{\mp}\rangle}$) also requires the same time $T$.'
author:
- Alberto Carlini
- Akio Hosoya
- Tatsuhiko Koike
- Yosuke Okudaira
date: 'September 29, 2010'
title: 'Time-optimal CNOT between indirectly coupled qubits in a linear Ising chain'
---

*To Alberto’s mother, Giovanna Novaro Mascarello.*

Introduction
============

Quantum optimal control theory is by now a very well studied subject, both theoretically and experimentally, with increasing applications in the field of quantum computing and information (for an updated review see, e.g., [@brif] and references therein). Quantum optimal control techniques aim, e.g., at finding either the best quantum state evolution


QB has been studied for quantum state evolution in the case of pure [@pure] and mixed states [@mixed], and for the optimal realization of unitary transformations between the identity and a given target quantum gate [@unitary]. The latter is particularly relevant for the standard quantum computation paradigm since a whole algorithm may be reduced to a sequence of unitary transformations between intermediate states and a final measurement. The more realistic situation where the target quantum state (gate) can be reached within a finite, tolerable error (a fidelity larger than a specified value) has also been addressed in [@fidelity]. The quantum brachistochrone problem always reduces to solving a fundamental equation, which can be easily written down once the constraints for the Hamiltonian of the quantum system are known, withrecently, Khaneja et al. [@khaneja2] considered the problem of the efficient synthesis of the controlled-[NOT]{} gate ($\mathrm{CNOT}(1, 3)$) between two qubits indirectly coupled via an Ising type coupling to a third qubit, and where the single qubits can be separately addressed via instantaneous local unitaries. Their implementation requires a time $T\simeq 1.253 J^{-1}\simeq \sqrt{\pi/2}~J^{-1}$, where $J$ is the Ising coupling between the qubits (1, 2) and (2, 3) in a linear coupling topology, and it was related to the computation of a geodesic on the surface of a sphere with a special metric and to the synthesis of a particular entangling gate called $U^s_{13}$. Subsequently, similar methods were used to extend these results to the case of unequal Ising couplings between the indirectly coupled qubits [@yuan] and to


is the identity matrix) and final conditions $(U(t=T)=U_f$, where $T$ is the optimal time duration necessary to achieve the target gate $U_f$). The quantum brachistochrone is a set of first-order (non linear) differential equations which can always be solved in principle, e.g. numerically, and it is universal, as it holds also in the case of time-optimal evolution of pure [@pure] and mixed [@mixed] quantum states.

More in details, for a given target gate $U_f$, the procedure to find the optimal Hamiltonian $H$ and the optimal time duration $T$ consists of the following stages: (i) specify the constraint functions $f_j(H)$ for the available Hamiltonian; (ii) write down and solve the quantum brachistochrone [(\[eq-fund\])]{} together with the constraints [(\[constraints\])]{} to obtain $H_{OPT}(t)$; (iii) integrate the Schrödinger equation [(\[eq-Sch\])]{} with $U(0)=1$ toget $U_{OPT}(t)$; (iv) fix the integration constants in $H_{OPT}(t)$ by imposing the condition that $U_{OPT}(T)$ equals $U_f$ modulo a global (physically irrelevant) phase, i.e., $$\begin{aligned}
  U_{OPT}(T)=e^{i\chi}~U_f,
  \label{targetU}\end{aligned}$$ where $\chi$ is some real number.

Ising Hamiltonian and Time-Optimal Entangler $U^s_{13}$
=======================================================

Now we apply the general QB formalism summarized in the previous Section to the case of a physical system of three qubits represented by three spins (labeled by a superscript $a\in \{1, 2,  3\}$) interacting via an Ising Hamiltonian with time independent couplings $J_{12}, J_{23}$ and subject to a local and controllable magnetic field $B^2_i(t)$ ($i=x, y, z$). In other words, we choose the three-qubit Ising Hamiltonian, $$\begin{aligned}
 H(t)\!\!& :=&\!\! \frac{\pi}{2}[J_{12}(t)\sigma_z^{1}\sigma_z^{2} +J_{23}(t)\sigma_z^{2}\sigma_z^{3}]
 +\vec{B}(t)\cdot \vec{\sigma}^{2},
\label{ising}\end{aligned}$$ where we have used the simplified notation, e.g., $\sigma_i^1\sigma_j^2:=\sigma_i\otimes \sigma_j\otimes 1$, $\sigma_i^2\sigma_j^3:=1\otimes


for the time-optimal Hamiltonian $H_{OPT}(t)$. In other words, we need to solve eqs. [(\[feq\])]{} together with the constraints [(\[cf1\])]{}-[(\[const-H\])]{} and with fixed parameters $J, \omega$. From the integral of the motion $B_z=\mathrm{const}$, eqs. [(\[feq\])]{} and the energy constraint [(\[const-H\])]{} we immediately obtain that $B_x^2+B_y^2 := B_0^2=\mathrm{const}$ while, from eqs. [(\[feq\])]{}, we further find the integrals of the motion $\nu_{zz}+\rho_{zz}=\mathrm{const}$, $\lambda_{zzz}=\mathrm{const}$. Exploiting these integrals of the motion and after some lengthy but elementary algebra, we find that the general and non trivial solution of [(\[feq\])]{} is given by the Hamiltonian [(\[ising\])]{} with the time-optimal magnetic field $$\begin{aligned}
  \vec{B}_{OPT}(t)= \left ( \begin{array}{c}
 {B_0}\cos \theta(t)\\
 {B_0}\sin \theta(t)\\
   B_z
  \end{array}\right )
  \label{bopt}\end{aligned}$$ precessing around the $z$-axis with the frequency $\Omega$, where $\theta(t):=\Omega t +\theta(0)$\mathrm{Diag}(-1, 1, 1, 1).
\label{ufus1}\end{aligned}$$ Imposing the target condition eq. [(\[targetU\])]{} with $U_{OPT}(t)$ given by eq. [(\[uoptexpl\])]{} and $U_f$ given by eqs. [(\[uf1\])]{}-[(\[uf2\])]{}, and separately equating the terms multiplying the Pauli operators $\sigma^2_x, \sigma^2_y$ and $\sigma^2_z$ and the identity operator $1^2$, respectively, we obtain the following set of conditions for operators acting on the 1,3 qubit subspace: $$\begin{aligned}
0&=&B_0\cos\phi(T) S_D^{13}(T), \label{tar1}\\
0&=&B_0\sin\phi(T) S_D^{13}(T), \label{tar2}\\
0&=&\sin\frac{\Omega T}{2} C_D^{13}(T) + \cos\frac{\Omega T}{2} B_D^{13}S_D^{13}(T), \label{tar3}\\
e^{i\left [\chi +\frac{\pi}{4}\right ]}U^{13}_D&=&\cos\frac{\Omega T}{2} C_D^{13}(T)-\sin\frac{\Omega T}{2}B_D^{13}S_D^{13}(T).
\label{tar4}\end{aligned}$$ From eq. [(\[tar4\])]{} (imposing the reality of its left hand side term) we immediately obtain the value of the global phase $\chi =(k-1/4)\pi$, where $k\in \mathbb{Z}$. Then, the only non trivial solution [@b0] for eqs. [(\[tar1\])]{}-[(\[tar2\])]{} is easily seen to be $S_D^{13}(T)=0$, which is possible, using eq. [(\[scoperators1\])]{}, if and only if $s_+(T)=s_-(T)=s_0(T)=0$


Rev. Lett.*]{} [98]{}, 040403 (2007). A. Mostafazadeh, [*Phys. Rev.*]{} [**A79**]{}, 014101 (2009).; id., [*Phys. Rev. Lett.*]{} [**99**]{}, 130502 (2007). P.E.G. Assis and A. Fring [*J. Phys.*]{} [**A41**]{}, 244002 (2008). A. Frydryszak and V. Tkachuk, [*Phys. Rev.*]{} [**A77**]{}, 014103 (2008). A.I. Nesterov, [*SIGMA*]{} [**5**]{}, 069 (2009). C.M. Bender and D.C. Brody, [*Time in Quantum Mechanics II*]{} (Springer, Berlin, 2010).

N. Khaneja, B. Heitmann, A. Sp" orl, H. Yuan, T. Schulte-Herbr" uggen, and S.J. Glaser, [*Phys. Rev.*]{} [**A75**]{}, 012322 (2007). H. Yuan, R. Zeier and N. Khaneja, [*Phys. Rev.*]{} [**A77**]{}, 032340 (2008). H. Yuan, S.J. Glaser and N. Khaneja, [*Phys. Rev.*]{} [**A76**]{}, 012316 (2007).

B.E. Kane, [*Nature*]{} [**393**]{}, 133 (1998); F. Yamaguchi, Y. Yamamoto, [*Appl. Phys. A: Mater. Sci. Process.*]{} [**68**]{}, 1 (1999). M. Mehring, J. Mende and W. Scherer, [*Phys. Rev.Entries are submitted to the HuDSeN database using the official gene name, according to the HUGO Gene Nomenclature Committee, at the time of uploading. If an official gene name subsequently changes after submission of the entry to the database, the previous name may be shown in the table above.


implant placement and significant dimensional changes in buccal wall take place 4--12 weeks following placement of immediate implants \[[@B7-dentistry-04-00021],[@B18-dentistry-04-00021],[@B19-dentistry-04-00021]\]. This was further supported by human clinical trials reporting up to 56% reduction in width of alveolar ridge following immediate implant placement \[[@B20-dentistry-04-00021]\]. In contrast to these initial results, numerous other studies published during the last 5 years report excellent survival rate, degree of osseointegration and maintenance of interdental bone levels with use of immediate implant protocol \[[@B21-dentistry-04-00021],[@B22-dentistry-04-00021]\]. The immediate implant placement in infected tooth sockets may also lead to successful osseointegration \[[@B23-dentistry-04-00021]\]. The aim of the present review is to analyze critical evidence from human clinical studies on the efficacy of immediate implant placement and to provide important clinical guidelines for esthetically pleasing outcomes.

2. Spontaneous Healing *vs.* ImmediateFollowing a pattern established by previous Assassin's Creed launches, the PC version of Assassin's Creed 3 has been delayed.

The PC version had been due out alongside the PlayStation 3 and Xbox 360 versions on 31st October. It will now launch on 23rd November 2012.

Eurogamer was tipped off about the delay by a publishing source who supplied the above promotional image to our Czech Republic cousins at Eurogamer.cz.

Ubisoft has a habit of delaying the launch of PC versions of its multiplatform games. The PC version of Assassin's Creed: Revelations was delayed by half a month, and the PC version of Assassin's Creed: Brotherhood launched in March 2011 after a November 2010 console release.

Most gamers believe these PC specific delays are the result of concern at Ubisoft over piracy, although


in any of the retested UBP mutants. However, a smear of higher MW forms migrating above the ubiquitylation doublet was specifically observed in the *ubp2Δ* mutant ([Fig. 1b](#f1){ref-type="fig"}; anti-Myc long expo). These observations confirm the specific involvement of Ubp2 in the regulation of Fzo1 ubiquitylation.

Given Ubp2 is an antagonist of Rsp5 (refs [@b23], [@b24]), we tested the involvement of this E3 in the regulation of Fzo1. Neither ubiquitylation ([Supplementary Fig. 1b](#S1){ref-type="supplementary-material"}) nor degradation ([Supplementary Fig. 1c](#S1){ref-type="supplementary-material"}) of Fzo1-13Myc were affected by deletion of *RSP5* (kept viable with the Spt23 p90 fragment which rescues the essential *OLE1*-Pathway in *rsp5Δ* cells, [Supplementary Table 1](#S1){ref-type="supplementary-material"} and [Fig. 4d](#S1){ref-type="supplementary-material"}). Most importantly, the Fzo1-13Myc smear seen with *UBP2* deletion persisted in *rsp5Δ+spt23\* ubp2Δ* cells ([Fig. 1c](#f1){ref-type="fig"}; compare lane 3 with lane 4). Similarly,the *OLE1*-pathway ([Fig. 4d](#f4){ref-type="fig"}), Rsp5 activates the synthesis of the Δ9-fatty acid desaturase Ole1. This enzyme catalyses the desaturation of the carbon 9--carbon 10 bonds of palmitic (16:0) and stearic acids (18:0) to produce palmitoleic (16:1) and oleic (18:1) acids, which are essential for cell survival and maintenance of mitochondrial distribution[@b31]. Importantly, endogenous levels of both the Ole1 protein ([Fig. 4e](#f4){ref-type="fig"}; *OLE1-9MYC* genomically tagged) and *OLE1* transcripts ([Fig. 4f](#f4){ref-type="fig"} and [Supplementary Fig. 4c](#S1){ref-type="supplementary-material"}) were decreased in *mdm30Δ* cells but were restored by either excess of Rsp5 or absence of Ubp2. Stabilization of Ubp2 in *mdm30Δ* cells thus results in downregulation of the *OLE1*-pathway.

Increased UFAs results in stabilization of Ubp2 and Fzo1
--------------------------------------------------------

A 38% decrease in the Ole1expression induces drastic accumulation of lipids with saturated acyl chains resulting in extensive


*ubp2Δ* cells, this doublet decreased by 50% at the benefit of Fzo1 high MW species regardless of the addition of oleic acid. These findings indicate that WT cells naturally adapt to increased UFAs by inhibiting degradation of Ubp2, thus resulting in inhibition of ubiquitin chain elongation and stabilization of Fzo1.

To extend this observation, we assessed the effects of UFAs on mitochondrial fusion *in vitro*[@b41]. Mitochondria were purified from cells in which the outer membrane protein OM45 was genomically tagged with GFP or in which genomically integrated mCherry was fused to a mitochondrial matrix-targeting signal. These mitochondria were mixed and stage 1 fusion reactions, which allow for outer but not inner membranes fusion[@b19][@b41], were carried out ([Fig. 5d](#f5){ref-type="fig"}). Outer membrane fusion was assessed by GFP and mCherry signals co-localizationouter membranes *in vitro* ([Fig. 5d](#f5){ref-type="fig"}). In this context, the imbalance between low levels of Ole1 and high levels of Fzo1 may contribute to promoting the mitochondrial fusion deficiency in cells that lack Mdm30.

To test this, *MDM30* null haploid strains of opposing mating types harbouring a control vector or an *MDM30* plasmid and expressing either mito-GFP or mito-RFP were grown with or without 0.1% oleic acid before mating. On the basis of the extent of co-localization between GFP and RFP in resulting zygotes, three categories of mitochondrial networks were identified ([Fig. 6a](#f6){ref-type="fig"}): those with perfect co-localization over the whole zygote (total fusion); those with co-localization in zygote daughter cells only (partial fusion); those with lack of co-localization over the whole zygote (no fusion).

Total fusion occurred in 98% of


and *rsp5Δ+spt23\* ubp2Δ* cells (DF5 background) transformed with pRS414-TEF-FZO1-13MYC were analysed by anti-Myc and anti-Rsp5 immunoblotting. Loading was normalized to Fzo1-13Myc levels. (**d**) CHX chase analysed by anti-Fzo1 and anti-Pgk1 immunoblotting with strains used in **c** but free of any plasmid. (**e**) Total protein extracts prepared from WT, *ubp2Δ* and *rup1Δ* cells (BY4741 background) were analysed by anti-Fzo1 and anti-Pgk1 immunoblotting. (**f**) Total protein extracts prepared from cells used in **e** but transformed with pRS414-TEF-FZO1-13MYC were analysed by anti-Myc immunoblotting. Loading was normalized to Fzo1-13Myc levels. Sol, soluble; OM, outer membrane; IM, inner membrane; IMS, inter membrane space; l-Mgm1, long Mgm1; s-Mgm1, short Mgm1.](ncomms15832-f1){#f1}

![Ubp2 antagonizes the degradation of Fzo1 that is mediated by Mdm30.\
(**a**) Quantification of CHX chases (bottom) with *WT*, *mdm30Δ*, *ubp2Δ* and *ubp2Δ mdm30Δ* cells (MCY572anti-GFP and anti-Por1 immunoblotting.](ncomms15832-f5){#f5}

![Increase in UFAs and Fzo1 rescue mitochondrial fusion in *mdm30Δ* cells.\
(**a**--**c**) *In vivo* mitochondrial fusion assays after mating between *mdm30Δ* haploid cells of opposing mating types (MCY970 and MCY971 parental strains) containing *MDM30*, *FZO1* or empty plasmids and expressing either mito-RFP or mito-GFP, respectively. (**a**) Examples of zygotes with mitochondrial networks totally fused, partially fused or not fused (scale bar, 5 μM). (**b**,**c**) Percentage of indicated zygotes with total (blue), partial (red) or no (green) mitochondrial fusion obtained from indicated cells grown in the absence or in the presence of 0.1% oleic acid. Error bars in **c** represent the s.d. from three independent experiments. \*\**P*\<0.05, \*\*\**P*\<0.005 (one-way analysis of variance (ANOVA)). More than 60 zygotes were analysed per sample.](ncomms15832-f6){#f6}

![Low Fzo1 levels and low UFAs support only


show that neither $SD_{k,2}$ or $D_{k,2}$ is a regular language for $k > 2$. In Section \[sec:ins\] we show how our languages $D_{k,p}$ are related to Kari’s theory of insertion [@Kari]. We show in Corollary \[cor:index\] that $D_{k,p}$ is an indexed language and $D_{k,2}$ is a linear indexed language for any $k,p > 0$.

We now make some basic observations about the languages $SD_{k,p}$ and $D_{k,p}$. Take any $k,p > 0$ and $w \in \Sigma^*_k$. First note we can check if $w$ is a $p$th-power in $O(|w|)$ time. We can check if $w$ is $p$th-power free in polynomial time since $w$ has only $O(|w|^2)$ subwords. Also, the length of any sequence of $p$-deletions starting with $w$ is $O(|w|)$. Therefore we can verify if sequence of $p$-deletions results in ${\epsilon}$ in polynomial time,and $|S_n|_b \equiv 0 \pmod p$ simultaneously. Thus, by Lemma \[lem:modp\] it follows that $S_n \not\in D_{2,p}$ for any $n \geq 0$.

Squares and Regular Languages {#sec:reg}
=============================

In this section we will given an explicit description of the languages $D_{k,p}$ and $SD_{k,p}$ for certain values of $k,p > 0$. For certain values of $k,p>0$ for which we can describe the languages $D_{k,p}$ and $SD_{k,p}$, these two languages turn out to be equal and are regular languages. We also show in this section to $D_{k,2}$ and $SD_{k,2}$ are not regular for $k > 2$. Recall that ${\mathbf{REG}}$ denotes the class of regular languages.

We first consider two trivial cases, for any $k,p > 0$ $$\begin{aligned}
D_{k,1} &= SD_{k,1} = \Sigma^*_k\\
D_{1,p} &= SD_{1,p} = \{w \in \Sigma_1^* : p \mathrm{\;divides\;} |w| \}\end{aligned}$$ Notice in both


a_{i+1} \cdots a_n a_n a_{n-1} \cdots a_j$$ since it must cross from $x$ into $x^R$ as both $x$ and $x^R$ are square-free. We claim that we must have $i = j$. Assume $i < j$ then we have some $i < \ell < n$ where $u = a_i a_{i+1} \cdots a_{\ell}$ and $u = a_{\ell+1} \cdots a_n a_n \cdots a_j$. We then see that the square $a_n^2$ must occur in $x$. This is a contradiction to $x$ being square-free. A similar contradiction is reached if $i > j$. So, $i = j$ and after deleting our square we obtain the word $a_1 \cdots a_{i-1} a_{i-1} \cdots a_1$ which is $2$-strongly-deletable by induction. Therefore it follows that $xx^R \in SD_{k,2}$.

If $x,y \in \Sigma_k^*$ such that $xy$ is square-free and\[thm:notreg\]

Let $L = SD_{k,2}$ or $L = D_{k,2}$ for some $k > 2$ and consider an infinite square-free word $w = a_1a_2 \cdots$ over $\Sigma_k^*$. Note an infinite square-free word exists whenever $k > 2$. Let $w_n = a_1a_2 \cdots a_n$ be the first $n$ letters of $w$. Consider $m < n.$ Then using Lemma \[lem:SD\] and Lemma \[lem:D\] we have $w_m w_m^R \in L$ but $w_nw_m^R = w_m (a_{m+1} \cdots a_n)w_m^R \not\in L$. Thus $w_m \not\sim_L w_n$ and $L$ is not regular since $\sim_L$ has infinitely many equivalence classes.

Insertion and Indexed Languages {#sec:ins}
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Given two languages $L_1$ and $L_2$ we get a new language $(L_1 {\leftarrow}L_2)$ called the *insertion* of $L_2$ into $L_1$ defined by $$(L_1 {\leftarrow}L_2) := \{xyz : xz \in L_1, y \in L_2\}.$$ Insertion can be iterated