or support for someone sick, less fortunate or symbolic of some greater good. Spectators lined the Street and were fully engaged. They offered “hand slaps” as runner passed by and cheered “doing great, keep it up”.

The run involved everyone even though there was little prize money and none beyond the top two or three men, women, and wheel chair entires. Involvement came from sheer enjoyment of living.

The Broad Street Run is an example of something money can’t buy. The 2016 Presidential election, however, may be something that can be bought, and if not, there will be mind blowing amounts of money spent trying.

The Federal Election Commission chairwomen said in a recent speech that the FEC was powerless to enforce campaign financing rules for the 2016 election. As aprecise pattern of dots is ejected from a drop-generating device known as a xe2x80x9cprintheadxe2x80x9d onto a printing medium. Inks normally used in ink-jet recording are commonly composed of water-soluble organic solvents (humectants, etc.), surfactants, and colorants in a predominantly aqueous fluid. When a recording is made on xe2x80x9cplain paperxe2x80x9d, the deposited colorants retain some mobility, which can be manifest in poor bleed, edge acuity, feathering, and inferior optical density/chroma (due to penetration of the paper). These features adversely impact text and image quality.
The evaporation rate of water-based inks is low and they dry primarily by the adsorption into paper. The adsorption time of an ink is dependent on many factors, such as the ink drop size, paper mesh size, ink viscosity, and the ink spreading coefficient over the


been disclosed, including polymer latexes, silica, alumina and titanium oxide particles, polymer resins, buffer solutions, and inorganic salts. All these underprinting liquids destabilize the pigment dispersions by various mechanisms. As a result, the pigment substantially precipitates at the surface of the paper, while the vehicle is quickly adsorbed.
Another system has been described that uses water-soluble dyes and an underprinting fixer. The fixer contains ligand-complexed metal ions (metal ion with an associated ligand). The ink used in this system contains an anionic component, which may be the dye itself. The ink may also contain a polymeric viscosity modifier in the ink. The specific polymeric viscosity modifier disclosed is an ethylene oxide adduct of acetylene glycolxe2x80x94a neutral polymer which unlike the present invention does not interact strongly with the fixer.
Another  return YES;
}

in viewDidLoad
initialize
_results=[[NSMutableArray alloc]init];
_countryNames=[[NSMutableArray alloc] initWithObjects:@"India",@"Pakistan",@"West Indies",@"Zimbabwe", nil];

connect search bar delegate from storyboard.


Why ride with us? People on bikes are generally more visible when we ride in groups; this added visibility can help us move more safely through the city. In addition, the routes we ride on our commuter-group rides are designed to feel as comfortable as possible on the busy streets of Los Angeles. Finally, we ride at a casual pace and are committed to staying together, so riders of all levels of experience are welcome and encouraged to join us. If you have any questions about joining with a commuter group ride, please contact the UCLA Bike Shop.

Palms to UCLA Join Liz from the UCLA Bike Shop for a casual commute from Palms. Palms Group Ride Weekdays at 9:00 a.m.

Northeast corner of Motor Ave. and National Blvd. (4.5but lives
religion. Ho mentioned the fact that
1 tbo church Is rapidly growing. To
keep paco with this growth tho
i church authorities havo decided to
H construct another templo of tho Lord
H It will bo built in Canada under tbo
English Hag bo said.
fl Wo do not boast of numbers but
H wo do boast of Intelligence. There is
not an equal number of peoplo in all
tho world that can boast of having
H moro intelligence than tho peoplo of
1 this wonderful organization of which
'J we are members. Thero aro never
H( any instructions given to this people
Hfj by their leaders but aro given by the
K spirit of revelation and it is tho duty
H of this peoplo to llvo lives that they
R will bo ablo to receive this lnstruc-
H- tlon and counsel.
H Miss Ethel Jensen sang


and any horticul
tural work, tho park department will
always assist, and in any expert
work along this lino will, If request
ed demonstrate, to promote, tho lovo
for beauty and to avoid disappoint
ments for amateurs. Desert Nows.
SAYS TROUBLE IS NOT
WITH OUR LAND BUT
WITH OUR FARMERS
JudBon C. Welllver, Washington
correspondent of Farm and Fireside
writes in tho current Issuo of that
periodical an interesting account of
tho United States Bureau of Soils.
Ho says In part:
"Dr. Milton AVhltney, chief of tho
soils bureau, Insists that proper cul
tivation and rotation will make run
down soils produce ngnln as well as
over. The trouble Is not with the
land, but with the people farming
it, and their methods, stoutly de
clares Dr. Whitney.
"Tho Bureau of Soils Is trying to
find out all about the changes In
soils thnt aro wrought as a result
of cultivation. It declares that tho
mineraland metal basis changes very
little. The products of vegetable and
animal growth, on tho other hund,,
change greatly nnd modify soil
qualities very much. Ono will bo
useful und benevolent, another vi
cious and harmful.
"A certain soil onco' producing ex
cellent crops of wheat, had become
"exhausted." Cow peas ground very
lino wero applied and It was found
they had restored the soil; It pro
duced a good crop, and did the thing
three times In succession; then the
soil lapsed back into its first condi
tlon of non-productivity
"Why did tho cowpeas havo tho
effect? Tifo Bureau took llko propor
tions of potash, phosphoric ncld and
nitrates tho plant food elements of
cowpeas and put them Into tho soli;
nnd It didn't produce tho effect of
restoring its fertility. Tho point
seemed to bo that theso various ele
ments, mixed together and applied
to the ground, didn't havo tho gen
uine


at Maro Is
lnnd nro morally certain that they
wero In communication last Monday
night with the now station at Arling
ton, Va., A message was received, tho
context of which indicated that Ar
lington was sending, but owing to lo
cal disturbances, tho slgnaturo at
the end of tho message was losL
When Arlington Is tuned up to full
power Maro iBland has no doubt that
it will be ablo to talk across tbo con
tinent. No report of what may havo been
accomplished last night in tho way
of direct communication with Arling
ton was given out todny at Maro Is-lnnd.
m t m
Woman loves a clear, rosy com
plexion. Burdock Blood Bitters, puri
fies the blood, clears tho skin, re
stores ruddy, sound health.
(Advertisement)
m m
IF YOU
Want n cook,
Want a clerk,
Want a partner
Wnnt a situation,
Want a servant girl,
Want to sell a piano,
Want to sell aprecinct, County of Cache,
State of Utah, before Wm. Brangham
Justice of the Peace, Cacho Valley
Banking Co., a corporation, plaintiff,
vs. T. S. Obary, dofendnnt, sum
mons. The State of Utah to tho De
fendant: You aro hereby summoned
to appear before tho abovo entitled
court within ten days after the ser
vice of this summons upon you, if
served within county in which this
action is brought, otherwise, within
twenty days after this service, and
defend the abovo entitled action;
brought against you to recover the
sum of 151.50 Interest and costs and
to foreclose an attachment on cer
tain real estate in Cache County par
tlcularly described in sheriff's return
to said writ. And in case of fail
ure to do so, Judgment will be ren
dered against you according to tho
demand of tho complaint.
WM. BRANGHAM,
Justice of the Peace.
LAW & HASRIS,
Attorneys for Plaintiff.
it, ,
NOTICE TO WATER


millennium with the potential to collapse the U.S. Federal Government, after it dissolves the Democratic Party and the Obama Administration. It was found out in a way that surprised all of those rich and powerful who are directly involved. Now that this genie is out of the bottle, there is no way of putting it back in. Hence, they will systematically kill every messenger that spreads any pejorative evidence or damning information.

TPTB can only “kill all the messengers” by taking a sweeping action against the Alt Media. The “fake news” meme began after PIZZAGATE and first made its way onto the Internet after election day. Not only did the MSM blame the Alt Media for the election of Donald Trump, they especially gin up the “fake news” chargeConcordance of sustained virologic response at weeks 4, 12 and 24 post-treatment of hepatitis c in the era of new oral direct-acting antivirals: A concise review.
The goal of treatment for chronic hepatitis C viral (HCV) infection is to cure the infection rather than suppress the virus. Historically, a sustained virological response (SVR) defined as undetectable HCV RNA at 24 weeks following the completion of treatment was considered the gold standard to define successful eradication of the virus as a primary endpoint in clinical trials. SVR measured at 12 weeks post-treatment has been shown to be highly concordant with SVR24 in trials of pegylated interferon and ribavirin. The appropriateness and durability of SVR12 as the efficacy endpoint with new oral direct-acting antivirals is less established. A literatura search was


Underpronation running shoes – Running shoes are the only piece of equipment you need to get started with a new running habit, but you can’t grab just any old pair of kicks if you underpronate.

Underpronation (or supination), is when your foot rolls to the outside as you step instead of transferring your weight equally across the bottom of your foot. It can increase your risk of ankle injury, Achilles tendonitis, IT band syndrome, and plantar fasciitis—painful conditions that can sideline you.

1 .Underpronation Running Shoes – ASICS Gel-Nimbus 20

Click to View Best Price for ASICS Gel-Nimbus 20 on Amazon

A lot of wearers commented that the Asics Gel Nimbus 20 was a comfortable running shoe. They were satisfied with its visually-appealing design and attractive color variations.

They loved wearing the shoeare comfortable, inconspicuous, and invisible from outside of the undergarment or clothing. Ideally, the personal care product should fully cover the user's pudendum and possess sufficient fluid capacity, yet remain essentially non-visible from the outside of the undergarment. In practice, fully covering the user's pudendum and possessing sufficient fluid capacity may result in an absorbent article that is less comfortable, more conspicuous, and more visible from the outside of the undergarment.
Historically, personal care products have been white and non-descript. This appearance conveyed a sense of a clean, hygienic, and sanitary product. In addition, the white, non-descript color permitted the personal care product to blend easily with undergarments that were also predominantly white. Currently, however, fashion trends have moved in the direction of colored and printed undergarments in a


              26.7

The average outdoor temperatures during the study periods were obtained from the Federal Office of Meteorology and Climatology MeteoSwiss, the USA National Oceanic and Atmospheric Administration, Met Office Hadley Centre Central England Temperature Data, the National Climate Data and Information Archive of Canada, Turkish State Meteorological Service, and the Central Weather Bureau of Taiwan (\*coordinated with http://www.geodata.us).

[^1]: Academic Editors: A. A. Romanovsky and A. M. Valverde
the U-Net architecture by using scale attention modules to fuse local and global information. The feature pyramid and attention mechanism inside the network for feature selection improves the accuracy of hyperspectral reconstruction.(3)We further designed the W-Net structure based on SAPUNet using boundary attention with a feature fusion scheme, deriving SAPWNet, which performed the best on the ICVL dataset.

2. Related Work {#sec2-sensors-20-02426}
===============

A number of methods have been proposed to address this hyperspectral recovery task. Some snapshot hyperspectral cameras are designed for obtaining spectral signals \[[@B2-sensors-20-02426],[@B18-sensors-20-02426]\]. A combination between hyperspectral and RGB cameras was developed for capturing hyperspectral data at high spatial and spectral resolution \[[@B9-sensors-20-02426],[@B13-sensors-20-02426],[@B19-sensors-20-02426]\]. Oh et al. \[[@B12-sensors-20-02426]\] reconstructed hyperspectral images using multiple consumer digital cameras, using different RGB cameras with different spectral sensitivities. Takatani et al. \[[@B11-sensors-20-02426]\]


data clustering with a Gaussian process to replace the dictionary atoms. Aeschbacher et al. \[[@B21-sensors-20-02426]\] developed A+ \[[@B22-sensors-20-02426]\] from super-resolution to hyperspectral reconstruction. Antonio et al. \[[@B23-sensors-20-02426]\] proposed using a constraint sparse coding method to reconstruct illumination-free spectra based on learning the prototype set. Yan et al. \[[@B16-sensors-20-02426]\] used isometric feature mapping to reduce natural scene spectra to a low dimensional space, then transformed three-to-many mapping (RGB to spectrum) to three-to-three mapping (RGB to 3D embedding of spectra), finally using a low-dimensional manifold reconstruction method for spectral recovery. This approach avoided establishing any priors based on the reduction from three-to-many to three-to-three mapping. This is typically accomplished by knowing the spectral response of the consumer RGB camera in advance.

CNNs have now become the dominant approach in different visionloss due to the decreasing gradient with increasing network depth \[[@B25-sensors-20-02426]\]. Deeper networks can lead to better model expressiveness, which can improve the performance of hyperspectral reconstruction. To solve these problems, we first replaced the feed-forward network by a residual network. Each layer in the residual block performs convolutions with filters to generate a heap of feature maps, then these feature maps are batch normalized and passed through a rectifier non-linearity (ReLU) activation function to produce the input of next convolution. A residual block output $x_{l}$ is defined as:$$x_{l} = \mathcal{F}_{l}\left( x_{l - 1}:\omega_{l} \right) + x_{l - 1}$$ where $\mathcal{F}_{l}\left( x_{l - 1}:\omega_{l} \right)$ is defined as a sequence of convolutions followed by ReLU and the batch normalization, and $x_{l}$ is the output of *l*th layer. $\mathcal{F}$


right side to optimize the network training process. We used the edge image extracted by the Canny algorithm to conduct the deep supervision. This method can guide the network to concentrate on reconstructing the recovery image detail through providing more semantic features. W-Net sums the boundary attention feature with the original U-Net on each scale, followed by 3 × 3 convolution and up-convolution to form the final module representation, which contains information about different receptive fields. Finally, the pixel-wise prediction is formed by connecting the fine-grained layers.

The W-Net structure with deep supervision has characteristics suitable for hyperspectral reconstruction. We wanted to reconstruct hyperspectral information from a single RGB image, which is a server ill-posed problem. Insufficient priors would cause edge blurriness in an image that has rich information.Ability to cold smoke, smoke, grill and bake (accessories may be necessary)

Ash Removal Tool

Grill Grate Lifter

Metal cradle with 4 casters / 2 locking

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The Large Round Primo grill is made of a thick Super Ceramic which is coated with a lead-free scratch-resistant glaze. Primo grills are the only kamado cookers that are made in the USA and backed by a 20 year warranty on it's ceramics. With this kamado cooker you can grill, smoke and bake like the pros. This versatility makes them a cost effective solution for all your outdoor cooking needs. Ceramic cookers are heavy by design, however Primos easy lift and lock hinge system makes using this cooker as easy as using a gas grill. The built in model has the ceramic


35 or 40 degrees in the air. The sensation created by this quite pleasant.

Eventually I got bored and ended up playing carny for about 3 hours, running the cyclofuge. Another weird thing about the downhill is that its this big bike party, then the bike people tend to thin out a bit, and all these Seattle suburbanite club kids start to trickle in. Not enough to take over or anything, but I was working the 'fuge and this one guy had just ridden it and was like "man, don't ride this thing if you're on E" and then I gave him my hand to pull him out the seat and he was covered in cold sweat. Yuck. Wipe that ride down with a sani-wipe.

While minding the 'fuge, theyou dare question the intentions of any of my baby girls... they are far better people than I can ever hope to be!

And then there are my friends... I have made so many new friends because of this wonderful computer age! Yes, I know there are dangers in the computing world, but there are dangers every way we turn. I am happy to say that the tatting community has offered me some of the best friendships of my life!

So, like Bing Crosby, tonight I will count my blessings instead of sheep!

Oh, you wanted to know about my tatting? Okay! Yesterday, my Raspberry Sorbet thread arrived Pamela! We were both getting a bit worried, because it took so long to get here! My theory... the postal workers could smell


know!

What happened to today? I really don't know! I looked for some knitting needles, got distracted with organizing my sewing room, found the knitting needles upstairs in the spare bedroom, watched a knitting video, tried the technique with no success, and then it was 5 o'clock!

I did manage to start a pair of socks for my grandson. I really don't think he'll want store bought socks with tatted or crocheted edgings like the girls are getting. I also managed to tat a little more of my Spinning Wheel, but that's about all I accomplished. I'm feeling awfully tired for getting so little done!

Thursday, November 12, 2009

I had great intentions of completing this Spinning Wheel in short order. However, Tuesday night I fell asleep in my chair... not muchtatting! Yesterday morning I thought I'd get a whole lot of tatting done. Then I remembered that I didn't do laundry over the weekend because of the play. Yes, I did tat... between phone calls! I visited with my daughter Alison (Squeaky Alligator) on the phone several times, and I talked with some friends as well. I'm no good at tatting while talking on the phone... shoulder cramps!

I also spent a lot of time online catching up on blog reading... boy, was I behind! I didn't leave many comments, but I did catch up on every single blog I could think of!

What's that saying, Mom? The road to hell is paved with good intentions? I guess it's a good thing that I had GREAT intentions rather than GOOD


of the way through the play!

Performances are tonight and tomorrow night at 7, and Sunday afternoon at 2. At 6 tomorrow there will be finger sandwiches and desserts for those who bought advance tickets. It's always a fun time, but there's always a ton of laundry and loads of dishes to wash afterwards!

To add to all the excitement, Carol (aka Madame Director) is getting sick... horrible cough, losing her voice, no energy... so I've been trying to make healthy germ-fighting meals this week. I have a feeling Carol's just going to collapse when she gets home Sunday night.

So, I'll tat a little bit here and a little bit there for relaxation, but I have a feeling it will be the middle of the week before Beatrice is shown/dts-v1/;

#include "rt3050.dtsi"

/ {
	compatible = "PWH2004", "ralink,rt3052-soc";
	model = "Prolink PWH2004";

	pinctrl {
		state_default: pinctrl0 {
			gpio {
				ralink,group = "spi", "i2c", "jtag", "rgmii", "mdio", "uartf";
				ralink,function = "gpio";
			};
		};
	};

	cfi@1f000000 {
		compatible = "cfi-flash";
		reg = <0x1f000000 0x800000>;
		bank-width = <2>;
		device-width = <2>;
		#address-cells = <1>;
		#size-cells = <1>;

		partition@0 {
			label = "u-boot";
			reg = <0x0 0x30000>;
			read-only;
		};

		partition@30000 {
			label = "u-boot-env";
			reg = <0x30000 0x10000>;
			read-only;
		};

		factory: partition@40000 {
			label = "factory";
			reg = <0x40000 0x10000>;
			read-only;
		};

		partition@50000 {
			label = "firmware";
			reg = <0x50000 0x7b0000>;
		};
	};

	gpio-leds {
		compatible = "gpio-leds";

		wifi {
			label = "pwh2004:red:wifi";
			gpios = <&gpio0 14 1>;
		};

		power {
			label = "pwh2004:green:power";
			gpios = <&gpio0 9 1>;
		};
	};

	gpio-keys-polled {
		compatible = "gpio-keys-polled";
		#address-cells = <1>;
		#size-cells = <0>;
		poll-interval = <20>;

		wps {
			label = "wps";
			gpios = <&gpio0 12 1>;
			linux,code = <0x198>;
		};
	};

	esw@10110000 {
		mediatek,portmap = <0x2f>;
	};

	wmac@10180000 {
		ralink,mtd-eeprom = <&factory 0>;
	};
};


\rceil} \enspace ,$$ so (\[eq:mn\]) is immediate.

Now, when $Q$ is called on $\Pi_n$, let $\rho(\Pi_n)$ be the pivot element, and let $\underline{\Pi}_n, \overline{\Pi}_n$ be the subarrays constructed for recursive calls to $Q$, where the elements in $\underline{\Pi}_n$ are less than $\rho(\Pi_n)$, and the elements in $\overline{\Pi}_n$ are greater.

We have $$\begin{aligned}
  E[ &\exp(-\lambda c_Q(\Pi_n)) ] \\
  &= \frac{1}{n} \sum_{k=1}^n
    E[\exp(\,-\lambda(n + 1 + c_Q(\underline{\Pi}_n) +
    c_Q(\overline{\Pi}_n))\,) \,|\, \rho(\Pi_n)=k] \\
  &= \frac{e^{-\lambda(n+1)}}{n} \sum_{k=1}^n
    E[\exp(\,-\lambda(c_Q(\underline{\Pi}_n) + c_Q(\overline{\Pi}_n))\,)
    \,|\, \rho(\Pi_n)=k] \enspace .
  \end{aligned}$$ It can be seen that given $\rho(\Pi_n)=k$, $\underline{\Pi}_n$ and $\overline{\Pi}_n$ are independent, thus $$\begin{aligned}
  E[ &\exp(-\lambda c_Q(\Pi_n)) ] \\
  &= \frac{e^{-\lambda(n+1)}}{n} \sum_{k=1}^n
    E[\exp(-\lambda c_Q(\underline{\Pi}_n)) \,|\, \rho(\Pi_n)=k] \,\cdot \\
         \frac{e^{-2\lambda(k-1)}}{((k-1)!)^{\lambda/\log(2)}}
          \frac{e^{-2\lambda(N-k)}}{((N-k)!)^{\lambda/\log(2)}} \\
    \intertext{(by the assumption)}
          &= e^{-3\lambda N + \lambda} \left( \frac{1}{N}
        \sum_{k=1}^N \left(  \frac{1}{(k-1)!}\frac{1}{(N-k)!}
      \right)^{\lambda/\log(2)} \right)\\
    &\leq e^{-3\lambda N + \lambda} \left( \frac{1}{N^{\lambda/\log(2)}}
      \left(  \sum_{k=1}^N \frac{1}{(k-1)!}\frac{1}{(N-k)!}
      \right)^{\lambda/\log(2)} \right) \\
    \intertext{(by Jensen's inequality, since \(0 < \lambda/\log(2) \leq 1\))}
      &= e^{-3\lambda N + \lambda} \left( \frac{(2^{N-1})^{\lambda/\log(2)}}{
      (N!)^{\lambda/\log(2)} } \right) \\
      &= \frac{e^{-2\lambda


is it attained?

If $ \sup_A S(A) $ is not attained then the situation is similar to that in Blum’s speedup theorem. Comparing $\sup_A S(A)$ among problems would be the expected-reward analog of computational complexity theory but because of the sensitivity of $S$ to parameters and the model of computation, this is not useful.

Self-Improving AI {#sec:selfimprovement}
=================

The generality of $\zp$ problems allows us to view design and analysis of [$ \mathbf{0}' $ algorithms]{} as a task which itself may be given to a [$ \mathbf{0}' $ algorithm]{}, bringing about recursive self-improvement. Here we present one possible concrete example of this notion and discuss connections with AI.

Computational problems with Turing degree $\zp$ are Turing-equivalent so without loss of generality in this section we assume [$ \mathbf{0}' $ algorithms]{} are automated theorem provers. Specifically,best)$ add $ (a_n, best, initialState) $ to $pool$ $improvementFound \gets \mbox{false}$ run Search($a, Z$) one step starting in state $state$ $newState \gets$ new current state of Search($a, Z$) in $pool$, mutate $(a,Z,state)$ into $(a,Z,newState)$ continue $improvementFound \gets \mbox{true}$ $best \gets $ output of Search($a, Z$) $score \gets a$ remove $(\hat{a},\hat{Z},\hat{state})$ from $pool$ print $best$ $initialState \gets$ initial state of Search$(a, best)$ add $(a, best, initialState) $ to $pool$

The procedure Improve has the following basic property.

Let $(Z_n)$ be the sequence of [$ \mathbf{0}' $ algorithms]{} printed by Improve. If $\beta(Z_0)$ holds, and if there is any [$ \mathbf{0}' $ algorithm]{} $Y$ and $s \in \mathbb{Q} $ where $\beta(Y)$ and $S(Y) > s > 0$ are provable, we have $$\lim_{n \rightarrow \infty} S(Z_n) \geq s


any believe of a comprehension universe knew a thought was absurd,” he writes. “First, a boss of a United States does not have a energy to sequence a drumming of anyone’s phone. Second, a thought of a British unfamiliar secretary signing a aver authorising such an penetration into domestic US politics was unthinkable.”

He goes on to highlight that a attribute between Britain and a US has been taken for postulated given a second universe war, formed on “unquestioned mutual trust”. He warns that any pierce to repairs it could mistreat common efforts to “counter terrorism, Russian aggression, a cyber-attacks of China, a chief hazard from North Korea and most else”.

Despite a roughly concept gibe and condemnation Trump has faced, a boss continues to hang doggedly to his wiretappingembrace on September 9

The theory, however, has been disproven, the New York Times reported.

Google told the Washington Times in June: 'Google Autocomplete does not favor any candidate or cause. Claims to the contrary simply misunderstand how Autocomplete works.

'Our Autocomplete algorithm will not show a predicted query that is offensive or disparaging when displayed in conjunction with a person's name.


same town. Sproglet is 18 months old, too young to go along. BF's car breaks down in a small town not quite an hour from the state border. Due to both towns' relative growth, the city they broke down in now is probably about the exact same size as the town we broke down in decades ago was.

Good news, it's a minor issue with his car, they've made appointments at a dealership in BigCity for when they get there and were only really put back a few hours. Everyone is fine. But it's kind of weird that this is on its way to family tradition...

I was sitting in the zocalo in the center of Guanajuato, Mexico, enjoying a coffee, when the plaza was suddenly invaded by about 2and frilly white blouses with tartan shawls. It was a grand sight.

The Scots retreated to a private dining room where they celebrated Burn's Nacht. They'd even brought their own haggis and we could hear, 'Ye chieftain o the puddin' race...'

The evening show in the theater paled by comparison.

I've been to quite a few Burn's dinners (X was a piper). They're fun, although like you, I'd not expect to see all that in the Caribbean. At one dinner, one of the elderly ladies had had more than a few drams of whiskey. When it came time to sing, "God Save the Queen," she said loudly, "The Female Dog!"

When I was still working in Washington DC we had some of our counterparts from South Korea travel over for training. They


day lost on which we have not danced at least once.

1973, London. I was 11. London at the time was a very interesting place for an Australian country-town pre-teen.

One day, the whole family stopped at a burger place somewhere in London - I think it was a Wimpy Burgers? Anyway, I'd finished, and the younger siblings were still eating, so I went outside for a walk up the street.

Near the restaurant was a men's wear shop. There was a crowd of men around the front window, so I got curious, and worked my way through the crowd. In the window was a very attractive young lady, wearing a pair of men's shorts and go-go boots - and nothing else. She was dancing away happily in the window.

I wonder100 beats per minute and a temperature of 38.5°C, whose heart rate slows to 60 beats per minute and who defervesces to a temperature of 36.5°C in recovery, would be predicted to have a 22 millisecond or 25% greater QT interval lengthening than an age- and sex-matched healthy afebrile participant with the same heart rate reduction independent of any drug treatment ([Table 3](#pmed.1003040.t003){ref-type="table"}).

10.1371/journal.pmed.1003040.t003

###### Predicted QT intervals at baseline and in recovery from malaria and fever.

![](pmed.1003040.t003){#pmed.1003040.t003g}


temperature, and individual study effects.

Sensitivity analyses {#sec014}
--------------------

The QT intervals of participants in studies that screened for and excluded individuals with torsade de pointes risk factors (*n* = 7,633) were not significantly different from those in studies without documented risk factor screening (*n* = 2,819) (mean difference: −0.78 milliseconds; 95% CI −9.69 to 7.88) once other predictors had been adjusted for. There were no clinically significant changes in predictor estimates when a cube root (Fridericia-like) instead of square root (Bazett-like) transformation of the RR interval was used (Tables I--L in [S1 Appendix](#pmed.1003040.s002){ref-type="supplementary-material"}).

The small effects associated with haemoglobin (−0.51 milliseconds per g/dL increase; 95% CI: −0.72 to −0.30) and parasitaemia (0.65 milliseconds per 10-fold increase in parasite density; 95% CI: 0.17 to 1.14) were of unclear clinical significance, and theseHeavy rainfall in Australia

Service Alert

Heavy rainfall in Australia

Australia Post has informed us that weather warnings have been issued across North Queensland (postcodes 4740, 4741, 4750, 4751 and 4798 to 4820). Heavy rainfall is forecast, leading to flash flooding. This will affect the collection and delivery of all mail products.

Australia Post thanks all designated operators for their understanding and will update once the situation has returned to normal.


book of Jonah. “I’m a nursing major, but this was one of my favorite classes. We studied the Old Testament, old movies, and I feel that it changed a ton of my perspectives,” said junior Maggie Finnegan. Due to the diverse mediums, from Hemingway to A Space Odyssey, you will never find yourself bored.

6. CONTEMPORARY CINEMA (CINE: 1610)

Counts for: Literary/Visual/Performing Arts

Binge-watching movies on your cramped phone screen can get tiring. It’s time to take it to the big screen. “I really enjoyed [Contemporary Cinema]. Every Wednesday night we had screenings to watch a movie. They were cool movies, too, movies that you wouldn’t usually watch,” said junior Leon Sun. These movies address several different issues regarding race, sexuality and gender, as well as spanning several different cultures andrefers to the place in theater where actors visit with people before the show, as well as a place where they can have “real conversations.” This class seeks to embody that relaxed and genuine atmosphere. Various speakers present their own walk of life to students as well as the community in the Englert Theatre. A few past speakers’ topics include new approaches to solving chronic homelessness, a man’s journey to becoming a professional magician and ways of leading diversity training. Through these speakers, discussion prompts, writing prompts and more, you may discover a passion you never knew you had. Not an honors student? Not to worry, you can always contact your counselor to request permission.

10. THE BLACK IMAGE IN SEQUENTIAL ART (AFAM: 2700)

Counts for: General Elective

You probably fell


to circumstances unattributable to either party, the Supreme Court refused to extend Munsingwear to a case which became moot due to settlement, stating that "[t]he principles that have always been implicit in our treatment of moot cases counsel against extending Munsingwear to settlement.  From the beginning we have disposed of moot cases in the manner 'most consonant to justice' ... in view of the nature and character of the conditions which have caused the case to become moot."  Id. at ----, 115 S.Ct. at 391.  (citation omitted).  Thus, Munsingwear should not be applied blindly, but only after a consideration of the equities and the underlying reasons for mootness.

8
The DEA has not cited any controlling precedent, either in the Third Circuit or the Supreme Court,merits."   Rather, we heard and determined the merits of the appeal.  As of the time our decision was filed, there was indisputably a live controversy between the parties, one that significantly impacted upon both Dr. Humphreys' reputation and his livelihood.  We therefore plainly possessed jurisdiction over the appeal.  Thus, in the true, i.e., jurisdictional, sense of mootness, the appeal is not moot.  As the Ninth Circuit once said when asked to vacate a decision it had already issued:

11
There is a significant difference between a request to dismiss a case or proceeding for mootness prior to the time an appellate court has rendered its decision on the merits and a request made after that time.  Different considerations are applicable in the two


there is no way to know whether Humphreys' registration would have been revoked had the DEA applied the correct legal standard in its analysis, we should avoid inflicting any further harm to Humphreys' reputation.

III.

18
We have carefully considered and discuss, seriatim, below each of the cases cited by the DEA in support of its argument that the required disposition of this motion is to vacate the panel's decision, withdraw the opinion and dismiss the appeal.  However, none of these cases compel the result urged by the DEA.  The only Supreme Court decision cited by the DEA, Stewart v. Southern Railway Co., 315 U.S. 784, 62 S.Ct. 801, 86 L.Ed. 1190 (1942), contains merely a one paragraph statement vacating the Supreme Court's earlier issued decision after the partiessettled while a petition for rehearing was pending.  In light of later Supreme Court case law, such as U.S. Bancorp, limiting the circumstances in which an appellate decision must be vacated and the lack of any explanation whatsoever for the actions taken in the Stewart case, it cannot be said that Stewart requires the DEA's suggested result in the present case.  Moreover, it is unclear in Stewart whether the petition for rehearing had actually been granted, thus entitling the parties to further review, or whether the petition had merely been filed.

19
All of the remaining cases cited by the DEA are from sister circuits and therefore not binding on us;  nor do we find them persuasive.  In one, the appellate court had already agreed to


posting for 1 hour out of those 24, then you were really only on the forum for that 1 hour. They are not the same thing.

To use a different analogy, if you go into a shopping mall and spend all of your time there going in and out of shops just looking at stuff, but not actually purchasing anything, you're not "shopping". You can be there for 3, 4, 5 hours, whatever. The fact of the matter is, if you don't walk out of that mall with a bag of stuff that you purchased, then you didn't "go shopping" at the mall, you just "hung out" at the mall. It doesn't make you a bad person or anything, but you can't say that you did something when youus your favourite song from them would be okay. Like Stryfe said, as long as it's obvious that you're not just spamming the board to get your access back, then you'll probably be fine.

In the end, as much as you may think that it sucks/is not fair and as much as you may want/choose to protest, this is the new policy that the staff here has chosen to have, and as such if you want access to those sections, you're going to have to proverbially "bite the bullet" and take part in some of the forum discussions so that you can get it back. If you still don't like it, well sorry, but that's how it is now. You're free to go elsewhere to get your gravure fix,


it uses a method in the SDK to get an authenticated URL to the Visualforce page that I was previously accessing in the desktop browser.
Now, when the same javascript queries the Chatter connect API, the URLs returned are relative, and look like this:

/services/data/v33.0/chatter/files/06924000000NdruAAC/rendition?type=THUMB240BY180

and so if I try to use this as a CSS background image, the webview (WKWebView) attempts to load this URL:

https://c.eu5.visual.force.com/services/data/v33.0/chatter/files/06924000000NdruAAC/rendition?type=THUMB240BY180

And now things are not so good. The WKWebView does not send an authentication cookie along with this request and so it fails to load with an invalid session ID error, and I've been unable to find a URL parameter that I can add to this to make it work (I've tried sid, oauth_token and _bearer which all seem
to have some use in various places).

Sendwell prepared to handle the increased demand for services. Also at the time, there was no pediatric-specific plan to either evacuate children in need of specialized care to centers with expertise in handling such patients or to mobilize pediatric practitioners (surgeons, critical care physicians, etc.) to the institutions where the masses of children would have initially been brought. Since then, there have been efforts to create educational materials to better prepare hospitals as well as proposals to create mobile pediatric disaster teams to deploy to hospitals in need of support. This review discusses these recognized and unrecognized issues in pediatric disaster preparedness to hopefully foster discussion for future strategies.


the stretch goals for the current campaign are various tools for encryption. In particular, Webber and Nicholson talk about incorporating Tahoe-LAFS, a cloud storage system that redundantly distributes encrypted files across multiple servers -- an addition that fits well into the concept of federation.

However, at the same time, Nicholson and Webber are aware from previous efforts to build a de-centralized web such as Diaspora that idealism is not enough. They suggest that such projects may briefly capture popular imagination, but require the effort of years before they start to have the intended effect.

To be successful, Nicholson suggests, projects like MediaGoblin not only need to help people move away from centralized services, but also to "provide something you don't get with centralize services, something people find exciting even ifI write, the current crowdfunding campaign has over a month to run, and is a third of the way to the first goal of $35 thousand. While fundraising campaigns tend to slow as they continue, Webber is cautiously optimistic of reaching the second goal of $60 thousands.

However, so far, there are no indications that a second campaign for software reduces interest, as some observers have suggested might be the case.

"I think we got so much done between the end of the last campaign and this one that it sort of sells itself," Nicholson says. "If we came back, and it was just like, 'Yeah, we were re-watching Buffy this year, but we would love to ask for money again,' then people wouldn't give us anything. But when we


or one or more nucleic acid sequences of hCMV DNA and one or more nucleic acid sequences of other target nucleic acids.
The problems noted above are overcome by using, in PCR, an aqueous composition buffered to a pH of from about 7 to about 9, which comprises:
(a) first and second primers which are specific to and hybridizable with, respectively, first and second nucleic acid sequences which are in opposing strands of human cytomegaloviral DNA (hCMV DNA) and which are separated from each other along the opposing strands by from 90 to 400 nucleotides,
(b) third and fourth primers which are specific to and hybridizable with, respectively, third and fourth nucleic acid sequences which are in opposing strands of a second target DNA which is the same as or differentfrom the first target DNA, the third and fourth nucleic acid sequences being different from the first and second nucleic acid sequences and being separated from each other along the opposing strands by from 90 to 400 nucleotides,
each of the first, second, third and fourth primers having a Tm within the range of from about 65 to about 74xc2x0 C., all of the primer Tm""s being within about 5xc2x0 C. of each other,the first and second primers having nucleotide lengths which differ from each other by no more than 5 nucleotides, and the third and fourth primers having nucleotide lengths which differ from each other by no more than 5 nucleotides.
This invention also provides a diagnostic test kit for the amplification of hCMV DNA and a second target


be the party of the century." "Yesterday, Lauren came up to me and in front of everybody, told me I was disinvited." "It was humiliating." "Why would Lauren do something like that?" "She's one of your best friends." "She was one of my best friends." "I have no idea why she's acting like this." "And she refuses to talk to me." "And Ashley's still invited." "And so is everyone else and..." "It's like I'm a social leper." "Well, Ashley's not going to go without you." "Just because I have leprosy doesn't mean he should." "Well, I think you should throw a rival party." "And invite all your friends to that one instead." "The party's tonight." "And she has a live band performing." "I can't compete with that." "Well,wasn't." "So who are you lying to, Luca?" "Me, or your wife?" "My wife." "I was with Angie last night." "You can ask her." "I could, but it doesn't mean I'm gonna believe her." "What were you and Burns fighting about?" "He was going to write something about me." "Destroy everything I've worked for." "I had to stop him." "And what was he going to write?" "About my pizza." "About what makes my fat-free pizza taste so good." "It's made with real cheese." "There's nothing fat-free about it." "You were going to kill for that?" "It's an expression!" "Besides, Burns called me last night." "He said he'd consider not running it if I'd do him a favor." "What favor?" "He didn't say what." "He was supposed to stop


him out of your hair for a couple of years, but then he caught your scent again at Nick's Pizza." "And that forced you to get rid of him permanently." "And then you fed us Harley, the sacrificial lamb to throw us off your trail." "Harley attacked me." "Oh, yeah, and then he managed to run down the fire escape with such incredible speed that two of New York's finest detectives were incapable of seeing him, never mind catching him." "Beating yourself up." "It was a nice touch." "You know what I just realized." "All those noir films that Cavallo draws his names from?" "They all have one thing in common." "A femme fatale." "I'd like my lawyer now." "Ah!" "Great." "You're still up." "Couldn't sleep if Iand evidence about their implementation and effectiveness. Scoping reviews are suitable for undertaking rapid mapping of the literature in areas where little previous investigation has been undertaken[@R37] [@R38] and can inform further research and practice.[@R37] They are concerned with 'contextualizing knowledge...and then setting this within policy and practice contexts' (p. 10).[@R39]

The objective of this review is to identify the features and effects of a pathway for emergency assessment and referral of patients with suspected TIA in order to avoid admission to hospital and gain timely access to appropriate outpatient-based specialist assessment.

Methods {#s2}
=======

We followed guidance for undertaking a rapid scoping review,[@R38] [@R46] while noting that specific advice for scoping reviews is not available[@R45] (see also <http://www.equator-network.org/>).

Eligibility criteria {#s2a}
--------------------

We included studies reporting descriptive and effectiveness data about assessment and referral


intervention and implementation of our trial. We also discussed methods and findings within the study team to assess and monitor processes.

We did not assess reporting quality of papers and chose to include all study designs in order to search widely across the research literature.[@R38] [@R41] However, all papers were published in international peer-reviewed journals and we have reported study results to aid interpretation, in line with recommendations.[@R38]

Implications for practice and research {#s4c}
--------------------------------------

Suspected TIA is common; identification and appropriate referral may be an opportunity to prevent subsequent stroke.[@R2] Timely access to specialist evaluation is therefore important, particularly since two out of three cases diagnosed in hospital can be missed and onward referrals from hospital to specialist services are often delayed.[@R13] [@R59]

This review extends the findings of Ranta and Barber[@R60]whether directly or indirectly.

And

(2) The foreign tax burden imposed on the PE must not be substantially lower than the tax imposed in Cyprus (6.25%).

Trading in Securities

Income arising from trading in securities is exempt from corporate tax.

The term “Securities” includes, but not limited to the following: ordinary participations (only if they result in titles); repurchase agreements or Repos on titles; participations in companies; units in open-end or closed-end collective investment schemes such as Mutual Funds; International Collective Investment Schemes (ICIS) and Undertakings for Collective Investments in Transferable Securities (UCITS).

Inheritance or Estate Tax

No Inheritance or Estates Taxes imposed in Cyprus.

Wealth Tax

No Wealth tax imposed in Cyprus.

Thin Capitalisation Rules

The Cyprus tax legislation does not impose any thin capitalisation. However, caution must be exercised in relation to interest deductions for loans used


participations and shares of the company and distribution of the proceeds to the non-resident shareholders. As such, the Cyprus Holding Company offers an ideal exit route.

EU Directives

Cyprus has fully adopted all EU Directives, including the Parent-Subsidiary, the Interest and Royalties, the Merger Directive and the Savings Directive.

VAT & Holding Company

If the sole purpose of a holding company is the purchase and holding of interest in shares in other companies with the intention of deriving dividend income, then the company will not be considered to be performing an economic activity for VAT purposes and thus will not be considered as a taxable person.

Companies which do not perform economic activities are not liable to register for VAT purposes and thus cannot claim input VAT.

Holding companies may become liable to registerQ:

How to load images in an ImageSwitcher from server?

I m trying to load images in an image switcher from Http server. I didnot find any function like setImageBitmap. So I tried using setImageURI() , but its not getting loaded.
I am tring to switch image after every 3 sec. This is the code. When i m running the codes image is not getting loaded. And app is also getting crased.
 String arr[]={"http://192.168.1.7/photos/dummy/1.jpg","http://192.168.1.7/photos/dummy/2.jpg","http://192.168.1.7/photos/dummy/3.jpg"}

 dailyWear = (ImageSwitcher) getActivity().findViewById(R.id.imageDailyWear);
dailyWear.setFactory(new ViewSwitcher.ViewFactory() {
        @Override
        public View makeView() {
            ImageView myView = new ImageView(getActivity());
            myView.setScaleType(ImageView.ScaleType.FIT_XY);


Five Things Car Dealers Dont Want You To Know

All you want is the best car for your money. All the dealer wants is to get the most money he can. That may mean trying to convince you to buy things that you really don't need. Here are 5 things car dealers don't want you to know when buying a new car or truck:

1 - The sticker price isn't really the price. Unless you're purchasing a vehicle at one of those no-hassle, no-bargaining, sales centers, never pay the sticker price. The dealer expects you to haggle, so go for it!

2 - Zero down, Zero interest, and Zero Payments for one year, will cost you more. In many cases, the first year may be virtually free, but then the buyersay, just a lot of posturing; I think I wanted to dress up like a G.I. Joe. In the years since, my politics changed, and I realized it was best to completely rebrand everything and start from scratch. The other guys involved didn't agree with my stance, so I went it alone.

Pitchfork: Better to Die works best as a complete record-- things bleed together, motifs return-- how'd you go about composing it?

MW: I wanted a grind album that sounded different, and I'm in love with the album as art, so I went for one long song, an operatic scope. But I realized grind needs the between-song silence as a psychological resting point, so if I made the album one long song, I'd have to do something to prevent


a breach of the only real dictate we have as beings: Be culpable for your freedom and make no act that denies someone theirs.

Still though, when the people are ready for it, liberty cannot be granted, it has to be taken. The U.S. is nowhere near that point. Most freak out when they see anarchists vandalize corporate storefronts during protests. We worship products like holy artifacts. So if most cannot or are unwilling to make the connection that the things they buy are sustaining harsh working conditions, poverty, environmental destruction, wage slavery, and the like, then no one has any business stabbing anyone with a broken compact disc. This shit is all around us. Most push it from their mind because of cognitive dissonance. Then discredit people likewas, what a stupid position I'd put myself in, all in the name of misplaced machismo, romantic notions of worldliness, and getting my teeth fixed. Out there in the field with a beat up Hemingway novel, who was I fucking fooling? I was a poor kid, I grew up in a cabin in the mountains, I had no insurance. Most of the guys I served with came from similar backgrounds.

Pitchfork: Are you still in graduate school now?

MW: I'm no longer in graduate school. I have my degree in English and was almost done with an MFA in Creative Writing when I became a student of the great Scottish author James Kelman. He's been called the Scottish Kafka or Beckett, and I'd hold him in just as high regard.


kk])
      firsti = np.nonzero(myview)[0][0]
      myview[firsti] = dostuff

Apart from performance considerations, I really do not know how to do this having different number of dimensions, and having the dimension I am interested in an arbitrary position.

A:

You can abuse np.argmax for your purpose. Here, you can specify the axis which you are interested in, where 0 is along columns, 1 is along rows, and so on. You just need an array which contains the same value for all elements that are not zero. You can achieve that by doing a != 0, as this will contain False (meaning 0) for all zero-elements and True (meaning 1) for all non-zero-elements. Now np.argmax(a != 0, axis=1) would give you the first non-zeroQ:

Convergence of a Recursively Defined Series: $a_n =5$, $a_{n+1} = 1/(6-a_n)$?

Determine whether the series converges or diverges. I have no idea how to go about this when it isn't defined in terms of n. Help is appreciated.
$$a_n =5, a_{n+1} = 1/(6-a_n)$$

A:

One can prove by induction that $a_n <1$ for all $n>2$.
Induction basis: $a_3=\frac {1}{5} <1$
Induction step: $$a_{n+1}=\frac {1}{6-a_n}<\frac {1}{6-1}<\frac {1}{5}<1$$
We used the induction hypothesis for the first inequality sign.
One can then prove that the sequence is strictly decreasing: $$a_{n+1}=\frac {1}{6-a_n}<\frac {1}{6a_n-a_n}=\frac {1}{5}a_n<a_n$$
We used our statement we proved before for the first inequality sign.
And since we proved that $a_n<1$ for $n>2$ it follows that $6-a_n >0$ and therefore all the elements of the sequence are positive.
All in all, we have proven that the sequence is strictly decreasing and bounded


40 IU/ml of human recombinant IL-2 (kindly provided by Shionogi & Co., Ltd., Osaka, Japan), 1 µg/ml of wild-type WT1~235~ peptide and 20 µg/ml of WT1~332~ helper peptide, plated into a 24-well plate, cultured for 1 week and then used for tetramer and intracellular cytokine staining assays. Statistical analysis was performed by means of the Mann--Whitney's *U* test.

### WT1 peptides-specific intracellular cytokine staining assay {#Sec11}

PBMCs were incubated with 1 µg/ml of WT1 HLA class I peptide or 10 µg/ml of WT1 HLA class II peptide in the presence of 2 µg/ml CD28/CD49d Costimulatory Reagent (BD Biosciences) and 10 µg/ml Brefeldin A (Sigma, St Louis, MO) for 5 h. Intracellular cytokine staining was performed using BD Cytofix/Cytoperm Buffer (BD Biosciences) according to the manufacturer's recommended procedures after surface staining of CD3, CD4 and CD8. The cells were thena 1-week culture in the presence of WT1 HLA class I (WT1~235~) and II (WT1~332~) peptides, and IL-2. The frequencies are shown for each patient pre- and 4--8 weeks post-WT1 vaccination

WT1 HLA class I peptide (WT1~235~)-specific IFN-γ-producing CD8^+^ T cells had increased markedly in 6 of the 11 patients (Fig. [4](#Fig4){ref-type="fig"}b), while WT1 HLA class II peptide (WT1~332~)-specific TNF-α-producing CD4^+^ T cells showed a marked increase in 10 of 11 patients 4--8 weeks after WT1 vaccination (Fig. [4](#Fig4){ref-type="fig"}c).

These results demonstrated that both WT1 HLA class I peptide (WT1 ~235~)-specific CD8^+^ T cells and WT1 HLA class II peptide (WT1~332~)-specific CD4^+^ T cells were induced by the cocktail vaccine of WT1 HLA class I and II peptides.

DTH of all patients for WT1 HLA class I and II peptides was negative before WT1


tetramer^+^ CD8^+^ T cells are shown pre- and at 4 weeks, 9 weeks, 16 weeks, and 1 year and 2 months post-WT1 vaccination. Upper and lower columns show tetramer assay without and with 1-week culture of PBMCs, respectively. **c** FACS analysis of cytokine-producing CD8^+^ and CD4^+^ T cells. Dot blots of IFN-γ- and/or -TNF-α-producing CD8^+^ and CD4^+^ T cells are shown pre- and at 4 weeks, 9 weeks, 16 weeks, and 1 year and 2 months post-WT1 vaccination. PBMCs were not re-stimulated or re-stimulated with either WT1~235~ or WT1~332~ peptide and analyzed

CD8^+^ and CD4^+^ T cells of patient 6 produced both interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) in response to WT1 HLA class I (WT1~235~) and II (WT1~332~) peptides, respectively, both time at 4 weeks, and 1 year and 2 months post-WT1 vaccination (Fig. [5](#Fig5){ref-type="fig"}c).

All four patients who survivedHerman Edwards yesterday compared Curtis Martin’s 196-yard effort in the Jets’ 31-24 win over the Bengals to the efforts of the great Jim Brown. Ironically, Brown phoned Martin after Sunday’s game to congratulate him.

“He knows that I’m committed to hard work,” Martin said of that conversation. “He said [to] keep it up.”

Martin has made no secret through training camp of his desire to erase the memory of last year, when he scored only two TDs the entire season. He matched that total in Week One, and No. 28 maintains that he’s healthier than ever and is ready to do some special things for the Jets this year.

“The night before [the Cincinnati game], in the meeting room,” Martin said, “I don’t know what it was, but I felt this


of the video. There was a reinforced security scheme to prevent leaks, with all guests having to leave their cell phones at the entrance and pass by a metal detector. Even media outlets had to shut down their equipment while watching the video. The video premiered on YouTube on October 9, 2015, just before the singer presented a special edition of Multishow's TVZ, where it was screened again. The video was shot in black and white, with animation and color effects. With her dancers, Anitta performs wearing white panties over a garter belt.

Controversy
A few days before the release of the video, Anitta launched a campaign on Twitter, where fans could win an exclusive session with the singer to watch it by uploading a hashtag with the name of-9*z**2 - 4280*z - 6636. What is p(-474)?
0
Let w(v) = -v**3 + 6*v**2 + 151*v + 112. What is w(16)?
-32
Let i(m) = 67*m + 4340. Calculate i(-65).
-15
Let w(q) = q**3 - 3*q**2 - 130*q + 708. Determine w(8).
-12
Let t(v) = 1640*v + 32790. Calculate t(-20).
-10
Let i(n) = -36*n**3 + 2*n**2 - 9*n - 22. What is i(-2)?
292
Let i(z) = 11*z - 102. What is i(22)?
140
Let l(a) = -48*a - 1260. Give l(-27).
36
Let l(j) = j**2 + 76*j + 751. Calculate l(-12).
-17
Let r(x) = x**3 - 29*x**2 - 23*x + 2087. What is r(27)?
8
Let v(m) = 7*m**3 + 9*m**2 - 15*m + 12. What is v(0)?
12
Let k(a) = 4*a + 52. Determine k(4).
68
Let m(q) = 303*q + 3606. Calculate m(-12).
-30
Let g(x) = -209*x - 476. Give g(-2).
-58
Let m(b) =


49761. Calculate i(25).
-11
Let a(n) = 14*n**2 + 132*n - 132. Give a(1).
14
Let b(n) = 19*n + 38. What is b(12)?
266
Let k(y) = -2*y**2 + 66*y + 376. Calculate k(-5).
-4
Let i(x) = 996*x + 1987. Determine i(-2).
-5
Let o(d) = -3*d**2 - 93*d - 257. What is o(-3)?
-5
Let h(i) = -i**3 + 24*i**2 - 38*i + 356. Determine h(23).
New Gun Laws in Illinois & the Effects on Domestic Violence Households

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New Gun Laws in Illinois & the Effects on Domestic Violence Households

By
Roscich & Martell Law Firm, LLC
|March 28, 2014

Illinois is about to see a
significant shift in its day-to-day life. Starting soon, the first 5,000 licenses to carry
a concealed weapon will arrive at residences. Reported by
The Chicago Tribune, the new law allows Illinois residents to apply for a license to carry
a concealed weapon out in public. The law, however, does not provide for
a right to shoot that weapon, except in situations where imminent danger
to yourself or others is present.

And though this new concealed weapon law is controversial in its own right,
it becomes even more so in the context of domestic violence, where a gun
may be used against a


  0.03     0.07  Array#any?
  1.26     3.95      0.06     3252     0.02     0.06  Gem::Version#version
  1.05     4.00      0.05    17117     0.00     0.00  Module#===
  1.05     4.05      0.05     2023     0.02     0.08  Gem::BasicSpecification#contains_requirable_file?

40% of its time in Gem::Dependency#matching_specs seems like a lot of something going on that must be optimisable.
I would appreciate any guidance on how to further investigate the reason thethe Korean Peninsula.

The EU implements all UN Security Council resolutions adopted in response to the DPRK's nuclear programmes and nuclear weapons, other weapons of mass destruction and ballistic missile programmes. In addition, the EU has imposed autonomous restrictive measures against the DPRK, complementing and reinforcing the UN sanctions regime.

The legal acts were adopted by written procedure. They will be published in the Official Journal of 9 April.


(lumen or protein) was given a specific color and named. Finally, the labeled stacks were visualized in 3D using Amira\'s \"SurfaceGen\" and \"SurfaceView\" modules without smoothing.

Results
=======

Methodological considerations
-----------------------------

Since objects or structures that appear to be separate entities on a standard histological section may in fact be connected when observed in three dimensions several techniques for the reconstruction of 3D structure from serial 2D histological sections have been presented \[[@B22],[@B27]-[@B29]\]. Here we present a novel digitized approach for high resolution 3D reconstructions of protein expression and vessel branching based on standard 2D sections \[[@B30]-[@B32]\]. The protocols developed are based on archival serial sectioned tissue samples applying state-of-the art image processing using Adobe Photoshop combined with the highly flexible software platform \"Amira\".

We employed and combined two different methods for creating 3D-reconstructions.and nestin were present along the developing sinusoids, and weak cytoplasmic laminin reactivity was observed in the primitive hepatocytes.

Three dimensional reconstruction of the \"ductal plate\" stage was performed on a portal area chosen from an embryonic liver aged 7 weeks + 2 days post conception (Figure [3a-d](#F3){ref-type="fig"}; Additional file [2](#S2){ref-type="supplementary-material"}). The reconstruction revealed that in this specific portal area three distinct portal veins had a common origin at one end of the stack, while appearing as entirely separate units at the other end. In a similar fashion, the ductal plates which had a common origin around the portal vein in one end of the image stack branched out as separate entities along each diverging portal vein. Several lumina in the ductal plates were traceable. However, the reconstruction revealed


SOX9) and hepatocytic (HepPar1) lineages \[[@B4],[@B23]-[@B26]\], we investigated human cholangiocyte tubulogenesis from 5 weeks + 6 days post conception and into adulthood. Our findings showed expression of both CK19 and HepPar1 in the ductal plates and in primitive hepatocytes during the embryonic period, corroborating previous investigations showing CK19 and HepPar1 to be early indicators of prospective liver development from the ventral endoderm \[[@B10],[@B33],[@B34]\]. Staining for CK19 on each consecutive section would have presented the ductal plate as a continuous sleeve of CK19 positive cells encircling the portal area. However, due to limited availability of prenatal human liver, only every 10^th^section was stained for the investigated markers. Correspondingly, our study and previously published reports observed EpCAM expression in both embryonic primitive hepatocytes and ductal plate cells \[[@B24]\]. Whereas ductalregulate progenitor cell fate. In the liver, the ductal plates have been hypothesized to constitute the prenatal and neonatal hepatic progenitor niche and to be antecedent to the Canals of Hering, the proposed adult progenitor niche \[[@B11],[@B13],[@B14],[@B39]\]. However, these studies were based on human fetuses no younger than 16 weeks of gestation, corresponding to 14 weeks post conception \[[@B11],[@B13],[@B39]\]. An interesting feature of immature hepatic progenitor cells is the absence of CK7 expression. This cytokeratin is expressed as hepatic progenitor cells acquire a mature biliary phenotype, which is in accordance with the demonstration of CK7 in the later stages of hepatic organogenesis \[[@B4],[@B40]\]. In our studies, the final commitment towards the biliary lineage in human liver was not observed until the fetal period at 13½ weeks post conception,


the duct remodeled into the portal mesenchyme in the other end. Therefore this stack actually represented several stages in the development of the intrahepatic biliary tree.

Conclusions
===========

In conclusion, our two different approaches to digitizing 3D-reconstructions allowed the visualization of hepatic protein expression patterns and the spatial relationship between hepatic vessels during human embryonic and fetal liver development and in human liver disease exemplified by acetaminophen intoxication. The presented protocols can easily be applied to future studies in directly unraveling the complex tissue architecture of liver and other organs in health and disease.

Authors\' contributions
=======================

PSV, KM, and HCB conceived the idea of the study. KM and HCB obtained the embryonic and fetal human livers. BV and BQ obtained the adult human livers. PSV, PJ and BMH optimized and performed the immunohistochemistry.this he can give all nearby squadmates a Target Lock and then a bonus action from his ability. Lt. Blount also gets a shout out because his ability will trigger the missile’s ability even if it’s technically a miss meaning he can’t waste it. Vaksai (Title) With Vaksai, these become free on a Kihraxz. If you aren’t using your missile slot, definitely load one up.

Comments

comments


   return [
            ['name', InputArgument::REQUIRED, 'The name of the command.'],
        ];
    }

    /**
     * Get the console command options.
     *
     * @return array
     */
    protected function getOptions()
    {
        return [
            ['command', null, InputOption::VALUE_OPTIONAL, 'The terminal command that should be assigned.', 'command:name'],
        ];
    }
}
Revised Core, while at the same time not making the meta all about those cards. While the current card pool is particularly vulnerable to specific powerful interactions that prevent me from reprinting some of the truly classic classics (Medium/Parasite + Contaminate/Knobkierie, Desperado + Crowdfunding, SSCG + Amani + CtM, Scorched Earth + HPT to name a few), there were quite a few cards from pre-Lunar that I was thrilled to play with alongside the most recent additions to the cardpool. I consider the current meta to be great right now, as is the Revised Core set, and introducing truly sweeping changes isn’t what we need right now.

The other main goal was to prepare for the rotation of Lunar and SanSan, which will be the next two cycles to


rotate when NISEI’s first fully fan-made set releases. Some of the cards didn’t make sense redesigning, and so they have been preserved. The number of cards being saved from these sets is smaller than Revised Core, and this is not due to lowered quality of card designs, but rather because at that point in time FFG’s designers had hit their stride and were making some incredibly powerful cards that, while I love, don’t define the game’s base power level in the way that the early cards did. Having said that there are a few cards that I consider absolutely perfect in effect and power level (Earthrise Hotel and Crisium Grid come to mind), and I’m very glad that System Core 2019 can keep them in the game forbeing vulnerable during that period is something I love about gameplay with Kati Jones: consider that it takes 6 clicks (an install, four charges, and one gain) with Kati for her to be more efficient than just installing Armitage and clicking it. When Kati is good, she’s great, but she is bad against rush play and is vulnerable by merit of being a resource and a connection. These two subtypes ended up serving as the backbone of this Core Set’s play.

With Kati Jones in everyone’s starting deck, all runner factions have the tools to contest a corp’s endgame, but at the same time the corp gains some devious ways of disrupting such a powerful economic tool. Paper Trail, Contract Killer, and the various tagging tools at NBN’s disposal


really make sense staying in the game forever. With that being said, we have one other means of reintroducing a small number of cards back to the game that I look forward to sharing with you, but you’ll have to wait until the rest of The Board gives me the OK to discuss it.

There is also a very small number of cards here that aren’t at risk of rotating at all, and simply fill a role that nothing else does as effectively, such as Paragon. These cards are here for the sake of the quality of experience playing exclusively with the Core Set. We want games to be fun and dynamic, and for players to learn how to improve as guided by the card pool; powerful cards thatof the following way…

Email to projectNISEI@gmail.com

In response to the post on Stimhack

By reply to this article on our Facebook page (I’ll update this link when it’s posted, in case you’re really quick off the mark)

So until tomorrow… *points mic at the crowd*


| gl | it | ja | ko | nl_NL | pl | pt_BR | ru | sv_SE | zh_CN | zh_TW ]

    Puppet hosts

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      Internet use is rising in emerging economies, but access to fast, reliable service remains elusive to many living in these nations. Some tech companies have been working to address this issue, as has the United Nations. But what role should the government play in getting all residents digitally connected?

A median of 65% across 11 emerging economies say it is the government’s responsibility to ensure that everyone has access to reliable internet service, according to a Pew Research Center survey of adults conducted last fall. Smaller shares – three-in-ten – say this should not be the responsibility of the government.

This sentiment is more pronounced in certain countries. For example, roughly three-quarters of adults in Venezuela and Lebanon agree it is the government’s responsibility to ensure that everyone has access


secure in the knowledge that it doesn't really matter all that much. For kids, though, it's a little different.

On balance, the character-building, fresh-air, good-fun good outweighs the screaming-thwarted-creepy-Little-League-dad bad when it comes to youth sports. That, or that and the parental wish to get kids the hell out of the house for a few hours a couple days a week, is why over 40 million kids in this country participate in youth sports. Again, it's worth it: children risk getting hurt in order to have fun/make friends/learn “teamwork”/pick flowers/be “active”/receive post-game snacks and et cetera, and parents accept the bargain. But with youth soccer being among the most popular of these sports, a recent Rock Center report on the wild ubiquity of concussions among young soccer players isfor all your blogging efforts.Capture His Heart Review

The rest of us just deal with getting progressively achier and worse at our sports of choice as our lives progress, secure in the knowledge that it doesn't really matter all that much. For kids, though, it's a little different.cheat castle clash |clash of clans tipps und tricks deutsch

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(C5+), and still more desirable to maximize the production of C9+ hydrocarbons. Components (C9+) that boil at temperatures above about 150° C., are herein defined as “heavy components” and are generally desirable, whereas C2-C9 are referred to herein as “light components.” Furthermore, light olefins, i.e. unsaturated hydrocarbons having 2 to 9 carbons, are typically not desired products.
It is not uncommon, therefore, to recycle light olefins to a Fischer Tropsch reactor, with the expectation that they will undergo further chain growth, as illustrated in FIG. 2A. Because the recycled olefins can also undergo hydrogenation and form the corresponding paraffins, however, as shown in FIG. 2B, it is not possible to ensure that the olefins will undergo the desired chain growth. Furthermore, because the Fischer-Tropsch reaction is inherently a hydrogenationand potentiodynamic ( ± 2 V) methods were compared with different electrolyte solutions as summarized in [Table 1](#tbl1){ref-type="table"}. The effect of electrolyte solution, generation of CCS and ROS from BDD and microbial inactivation mechanisms was previously described by Jeong et al. ([@bib20]; [@bib22]), but will now be briefly summarized. NaCl (0.154 M) electrolyte solution allowed study of disinfection of blackwater when Cl^−^, H~2~O, and O~2~ were present in solution to create CCS and ROS. In this case, microbial inactivation was caused by direct redox, CCS, and ROS. KH~2~PO~4~ (0.2 M) provided the similar conductivity as 0.154 M NaCl but allowed study of disinfection of blackwater without addition of Cl^−^, other than that naturally contained in urine which is ∼5.6 g L^−1^ NaCl ([@bib34]), leaving only reactants for ROS (H~2~O and O~2~) present. In this case, microbial inactivation


the ± 2 V method indicated that reverse polarization and continued regeneration of the functional groups significantly increased the generation of CCS. As stated in the methods section, no residual chlorine was found in solution prior to electrolysis. Moreover, the pH for all diluted blackwater solutions was pH 7 so volatilization of free-chlorine should be minimal as has been reported previously in literature ([@bib39]).

A proposed mechanism of increased CCS generation resulting from appropriate pre-treatment and potential cycling is shown in [Fig. 3](#fig3){ref-type="fig"}. Pre-treatment of the BD-UNCD electrode surface in 0.5 M H~2~SO~4~ plays a vital role in how well Cl^−^ adsorbs, summarized as follows. Step 1: Oxidation in H~2~SO~4~ creates oxygenated functional groups on non-diamond content on the BD-UNCD surface ([@bib46]). Step 2: Anodic polarization of the functionalized electrode in Cl^−^-containing solutions (indiluted blackwater can save on energy expenditure required for disinfection of microbial species. Functionalization of BD-UNCD electrodes through potential cycling is shown to provide binding sites for improved electrochemical processes. Subsequent potential cycling of the functionalized BD-UNCD electrodes serves the dual purpose of maintaining these binding sites, which can become fouled with time, as well as keeping their catalytic properties active. Through a 24 h study in undiluted blackwater, the potential cycling of BD-UNCD is demonstrated to yield a more energy efficient disinfection process compared to two other potentiostatic methods. This work adds to the continuing investigations of oxygen reduction reaction (ORR) catalysts and electrochemical advanced oxidation processes (EAOP) using functionalized carbon materials that have the potential to bring a cost-effective, energy efficient, and practical solution to the


#if !defined(BOOST_PROTO_DONT_USE_PREPROCESSED_FILES)

    #include <boost/proto/detail/preprocessed/template_arity_helper.hpp>

#elif !defined(BOOST_PP_IS_ITERATING)

    #if defined(__WAVE__) && defined(BOOST_PROTO_CREATE_PREPROCESSED_FILES)
        #pragma wave option(preserve: 2, line: 0, output: "preprocessed/template_arity_helper.hpp")
    #endif

    ///////////////////////////////////////////////////////////////////////////////
    // template_arity_helper.hpp
    // Overloads of template_arity_helper, used by the template_arity\<\> class template
    //
    //  Copyright 2008 Eric Niebler. Distributed under the Boost
    //  Software License, Version 1.0. (See accompanying file
    //  LICENSE_1_0.txt or copy at http://www.boost.org/LICENSE_1_0.txt)

    #if defined(__WAVE__) && defined(BOOST_PROTO_CREATE_PREPROCESSED_FILES)
        #pragma wave option(preserve: 1)
    #endif

    #define BOOST_PP_ITERATION_PARAMS_1      animals were maintained in accordance with IACUC guidelines.

Cell culture and reagents {#s4.2}
-------------------------

Human breast cancer cell lines BT474, ZR75-1 and MCF-7 cells were previously purchased from American type culture collection (ATCC). To generate these cells that express firefly luciferase (BT474-luc, ZR75-1-luc, MCF7-luc), the parents cells were transfected with EF1-luc plasmid and selected for clones stably expressing the firefly luciferase. pLKO-Tet-on-shMED1 plasmids were constructed by inserting shRNA sequences against MED1 or control GFP into pLKO-Tet-on vectors \[[@B49],[@B50]\] and packaging them into lentiviruses as described \[[@B40]\]. These lentiviruses were then used to infect above luciferease expressing cell lines to generate BT474-tet-shMED1, ZR75-1-tet-shMED1 and MCF-7-tet-shMED1 and corresponding tet-shGFP control cells. All cells were maintained in DMEM medium supplemented with 10% fetal bovine serum (Hyclone) and 1µg/ml puromycin (Invitrogen). MCF7-F, a fulvestrant-resistant subline


presence of fulvestrant.

(TIF)

######

Click here for additional data file.

We thank Drs. Shuk-Mei Ho, Sohaib Khan, Susan Waltz, and X. Zhang lab members for helpful discussions, and we thank Yaoxian Xuan for her support.

[^1]: **Competing Interests:**The authors have declared that no competing interests exist.

[^2]: Conceived and designed the experiments: LZ JC XZ. Performed the experiments: LZ JC. Analyzed the data: LZ JC ML KN YL XZ. Contributed reagents/materials/analysis tools: LZ JC ML KN YL XZ. Wrote the manuscript: LZ JC ML XZ.
1. FIELD OF THE INVENTION
The present invention relates to an amplitude detecting device for detecting an amplitude of a sinusoidal signal, which is especially useful for processing a signal output of a touch signal probe.
2. Prior Art
Conventionally, as a measuring apparatus for measuring shape or size of a to-be-measured object, a height gage, a three-dimensional measuring apparatus, a contour measuring apparatus and so on, are used. A contact-type measuring apparatus in the above-mentioned measuring apparatus has a touch signal probe which is used for detecting contact with the to-be measured object. Various contact detecting mechanism of the touch signal probe have been provided. One of these mechanism is to drive a piezoelectric device for applying vibration to a stylus. This method is useful for obtain a high-speed and


to him by saying, “Thou art the Christ, the Son of the living God.”

Because of Simon Peter’s answer, the Bible says that Jesus told Peter his response was not revealed to him by flesh or blood, but by God, to which Jesus further informed Peter that He would use him to build His church and that “the gates of hell” would not prevail against it.

For those of us who are faith-filled Bible believers, we have heard this powerful passage of scripture before, and have either quoted it or prayed it over our lives. But, the question I have to the church, which is simply those who are believers, is has the church been collectively weakened to the point that it has allowed “the gates of hell” to prevailGSA clears final FAS hurdle

The General Services Administration has completed negotiations with the two labor unions that represent its employees, and can now fully launch the long-planned Federal Acquisition Service.

FAS replaces the Federal Supply Service and Federal Technology Service, combining their functions into a single organization, GSA officials said today. Companies that supply products and services to GSA's customers should find the agency much easier to deal with now, they said.

"What we are hoping for is to provide more standardization in our contracts," said Barney Brasseux, acting deputy FAS commissioner. "It should be a more efficient process for both us and our industry partners."

Gary Feit, assistant commissioner of the office of customer accounts and research assistant, added that the purpose of combining the two services is to make


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                    &&
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                if (this.leftCalendar.month.format('YYYY-MM') != this.startDate.format('YYYY-MM') && this.rightCalendar.month.format('YYYY-MM') != this.startDate.format('YYYY-MM')) {
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                var inMinYear = currentYear == minYear;
                var inMaxYear = currentYear      html += '</table>';

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         this.container.find('input[name=daterangepicker_end]').val(this.endDate.format(this.locale.format));

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        },

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 devices
              .on('touchend.daterangepicker', this._outsideClickProxy)
              // also explicitly play nice with Bootstrap dropdowns, which stopPropagation when clicking them
              .on('click.daterangepicker', '[data-toggle=dropdown]', this._outsideClickProxy)
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              .on('focusin.daterangepicker', this._outsideClickProxy);

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label;
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                var dates = this.ranges[label];
                this.startDate = dates[0];
                this.endDate = dates[1];

                if (!this.timePicker) {
        between selecting a start and end date for the range,
            // * if the time picker is enabled, apply the hour/minute/second from the select boxes to the clicked date
            // * if autoapply is enabled, and an end date was chosen, apply the selection
            // * if single date picker mode, and time picker isn't enabled, apply the selection immediately
            //

            if (this.endDate || date.isBefore(this.startDate, 'day')) {


= end.clone();

                this.setStartDate(start);
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                if (isRight) {
                    this.container.find('input[name="daterangepicker_start"]').val(this.startDate.format(this.locale.format));
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                }

  product

And I have the following error:
The QuerySet value for an exact lookup must be limited to one result using slicing.

company_pk and product_pk are just variables.  If I remove the Product filter there is no error.
I presume it happens because company result is a QuerySet and is pushed as argument in Product.objects.filter

A:

Company is a queryset. You might want to do
Product.objects.filter(company=company[0], pk=product_pk)

Or better yet you can use the relations in the ORM to simplify into 1 lookup.
Product.objects.get(company__account=account, company__pk=company_pk, pk=product_pk)

A:

As said in the accepted answer, company is a queryset.

The QuerySet value for an exact lookup must be limited to one result using slicing.

Instead of this

product = Product.objects.filter(company=company, pk=product_pk)

try this

product = Product.objects.filter(company__in=company, pk=product_pk)

__in can handle querysets larger than one (multiple records of a table).
This can be found in the


that of the phone in the

classroom where M.C. made the call. He then notified the school resource officer, who testified that

he confirmed with the dispatcher that they received a 911 call. At the hearing, in response to

questioning from M.C.’s attorney, the officer confirmed that he got the phone number from which

the 911 call originated from the dispatcher, who got it from the “911 operator.”

                M.C. appeals on the ground that the evidence is legally and factually insufficient to

support the conclusion that the phone call was made to a “public safety answering point” employee

within the statute.

                  support

the trial court’s finding that the call was made to a “public safety answering point” employee, we

overrule M.C.’s points of error and affirm the judgment.

                                                __________________________________________

                                                Jan P. Patterson, Justice

Before Chief Justice Law, Justices


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of resistance to oppression even when such resistance might lead to violence. In using Thoreau to inform his understanding of the conditions under which violence could be legitimate, Mehanna developed a strand in Thoreau’s political thought that is increasingly coming into focus in our postcolonial age, at a time when Muslim thinkers have begun to make a virtue of civil disobedience.

A close reading of Thoreau’s manifold writings on the question of violence leaves the reader with an impression of profound ambivalence. On the one hand, Thoreau meticulously avoided violence in his personal life. He reportedly quit his first teaching job because he refused to engage in corporeal punishment. On the other hand, his celebration of the abolitionist John Brown, convicted and executed in 1859 for leading a violent       TaKaRa, Japan
  pET-32a (+)                         *E. coli* expression vector with 6× His-tag at C-terminus and center, and a thioredoxin-tag at N-terminus, T7 RNA polymerase gene promoter and terminator; Amp^r^                                     Novagen, United States
  pET-SUMO


a default setting. Basically, the reactions were performed in sterilized 1.5 mL centrifuge tubes containing 0.5 mL PBS, 10 μL purified carboxylesterase CesB and defined volumes of pyrethroids to obtain a final concentration of 20 mg L^--1^. The mixtures were incubated for 2 h and then supplemented with 0.5 mL acetonitrile for ultrasonic extraction. Suitable amount of sodium chloride was added to make the solutions saturated. The supernatant phase was used to determine the pyrethroid residues by HPLC. One activity unit (U) was defined as the amount of enzyme needed to catalyze 1 μg of the pyrethroids per minute. The optimal reaction conditions and substrate of the enzyme activity was expressed as 100%, and the others were represented as relative enzyme activity.

For the substrate specificity assay, six pyrethroidsPytH, ACM79141; and PytZ, AEY11370) elucidated that CesB protein belonged to the hydrolase family VI with a characteristic α/β hydrolase fold. Besides, the conserved pentapeptide sequence motif Gly--X~1~--Ser--X~2~--Gly ([@B22]), which was Gly--Phe--Ser--Leu--Gly in this case ([Supplementary Figure S2B](#SM1){ref-type="supplementary-material"}), is regarded as the typical "nucleophilic elbow" in α/β-hydrolases. Secondly, the recombinant protein CesB was successfully expressed in a pET32a (+) expression vector by inserting *cesB* gene, and the total molecular mass of purified recombinant CesB was determined at approximately 50 kDa with His-, Trx-, and S-tag ([Figure 2A](#F2){ref-type="fig"}). The recombinant protein was soluble and its concentration was determined at 210.8 μg mL^--1^ by the previous BSA calibration.

![Characterization of CesB. **(A)** The purification of the recombinant CesB protein (M, protein marker; lane 1, purified recombinant); **(B)** 3D model of CesB;


of 4 Å. Based on the results from CDOCKER, the optimal conformation of CesB was determined with a deep, wide and irregular ligand-binding pocket that benefits the β-cypermethrin ligand to enter and bind firmly ([Figure 2D](#F2){ref-type="fig"}). Moreover, the molecular docking revealed several hydrophobic amino acid residues (such as leucine and phenylalanine) around the binding site, constituting the active hydrophobic entrance ([Figure 2E](#F2){ref-type="fig"}). In general, small organic molecules can bind to active proteins by various strategies, such as hydrophobic effect, hydrogen bond and van der Waals force, etc. Since no hydrogen bond was discovered linking the β-cypermethrin ligand to carboxylesterase CesB, they more likely interacted via van der Waals and other electrostatic forces.

Five key amino acid residues including Leu64, Lys92, Leu130, Phe161, and Leu172 were lined in the entranceGuangdong Province (2018B020205003), Youth Talent Program of Higher Education in Guangdong Province (2018KQNCX024), National Natural Science Foundation of China (Grant No. 31871988), and Guangdong Province Science and Technology Plan Project (No. 2015B020207003). YX specially appreciates the support from Guangdong Academy of Sciences (GDAS) Special Project of Science and Technology Development (2017GDASCX-0849 and 2019GDASYL-0301002) and the Science and Technology Program of Maoming (190710144931808).

<http://www.ncbi.nlm.nih.gov/BLAST>

<http://web.expasy.org/protparam/>

<https://npsa-prabi.ibcp.fr/cgi-bin/npsa_automat.pl?page=npsa_sopm.html>

<https://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml>

[www.bioinformatics.org/primerx/cgi-bin/protein_1.cgi](http://www.bioinformatics.org/primerx/cgi-bin/protein_1.cgi)

Supplementary Material {#S8}
======================

The Supplementary Material for this article can be found online at: <https://www.frontiersin.org/articles/10.3389/fbioe.2020.00889/full#supplementary-material>

######

Click here for additional data file.

[^1]: Edited by: Nikolaos E. Labrou, Agricultural University of Athens, Greece

[^2]: Reviewed by: Quanfeng Liang, Shandong University, China; Madalina Tudorache, University of Bucharest, Romania

[^3]: This article was submitted to Industrial Biotechnology, a section of the journal Frontiers in Bioengineering and Biotechnology


for memorizing kanji, but radicals are a great way to get started. Unfortunately for me, I didn’t learn about radicals until three years into studying Japanese– and even then, I learned about them from my tutor (yup– sadly, I get tutored) and not in class. But it’s never too late– I’ll definitely be studying more about radicals in the months to come!

And now, some disclaimers:

I’m not a Japanese teacher– I simply had the honor of being invited to write a guest post for Aha! Sensei. If you liked this post, you can check out my site, I think in comics!

I’m no expert, by any means. If you’d like to know more, I’d check out these pages (because I certainly did while writing this post)

The 5 Biggest Mistakes PeopleReceipt of vaginal-cervical stimulation modifies synapsin content in limbic areas of the female rat.
Female rats require a sufficient amount and pattern of vaginal-cervical stimulation to initiate neuroendocrine changes required for the successful implantation of a fertilized ovum in the uterus. These changes are characterized by twice daily prolactin surges that last 10-12 days. Following a sterile mating, the endocrine changes are still observed, and are termed pseudopregnancy (PSP). The mating stimulation required to initiate these changes prior to pregnancy or PSP has a neural representation, which we have termed the intromission mnemonic. We sought to examine if the formation of the intromission mnemonic is accompanied by alterations in the number or density of synapses in limbic areas by immuno-labeling a pre-synaptic protein, synapsin. Groups of cycling female rats


patients with drug-susceptible tuberculosis in Cape Town.

Methods {#s2}
=======

Study {#s2a}
-----

The primary study was a randomized, double-blinded study that examined the effect of vitamin A and zinc supplementation on the efficacy of the standard combination regimen in the treatment of drug-susceptible tuberculosis.^[@DKU136C11],[@DKU136C12]^ The primary study was approved by the Ethics and Research Committee of the University of Cape Town and registered at <http://controlled-trials.com/ISRCTN80852505/80852505>. All patients gave their written informed consent. The study was performed at Delft Community Health Center in Cape Town, Western Cape Province, South Africa, between May 2005 and August 2008. Participants were aged between 18 and 60 years and had a positive sputum smear. Exclusion criteria included a history of prior tuberculosis, extrapulmonary tuberculosis, renal or heart failure, elevated alanine aminotransaminase concentrations, corticosteroid use and evidence ofthe ROC score of the test sample.

Statistical comparisons {#s2e}
-----------------------

Clinical factors, such as low antibiotic AUC and peak concentrations, bacillary burden at diagnosis (we utilized time to positivity of sputum cultures at diagnosis), presence of cavities on chest X-rays and age are also risk factors of poor 2 month sputum conversion.^[@DKU136C2],[@DKU136C12],[@DKU136C20]^ We wanted to take these into account, in order to further delineate the role of the CART analysis-derived susceptibility breakpoint. First, we examined the 2 month sputum conversion outcomes between patients whose isolates had MICs above the CART analysis-derived breakpoint versus those with MICs at or below the breakpoint. These variables were thus compared among the two groups of patients comprising those with isolates above the CART analysis-derived MIC breakpoint versus the rest. Continuous variables were tested for


body weight, but 50 mg/L with weight adjustment (i.e. between 25 and 50 mg/L). These values are the exact ones identified by CART analysis, an agnostic method, with the primary and secondary outcomes in the current study. However, the susceptibility breakpoint of 50 mg/L was associated with statistically significant differences regarding outcomes in patients on standard therapy and is therefore recommended for laboratory use. This value is close to the 64 mg/L proposed by Werngren *et al.*^[@DKU136C7]^ based on MIC distributions for isolates in Europe. Nevertheless, our current data, especially those presented in Figure [1](#DKU136F1){ref-type="fig"}, strongly suggest that these distributions vary from locale to locale.

An examination of the literature could also help to suggest the approximate range for the pyrazinamide MIC susceptibility breakpoint. We have found that a pyrazinamidemanagement, analysis and interpretation of data; and preparation, review or approval of the manuscript.

Transparency declarations {#s6}
=========================

T. G. has received research grants from Merck for work on antifungal agents. T. G. has worked as a consultant for Astellas Pharma US Inc. on antifungal work. T. G. founded Jacaranda Biomed Inc. All other authors: none to declare.

We would like to acknowledge the patients and nursing staff of the Delft Community Health Center in Cape Town.


denied 100 percent of workers comp claims from firefighters since 2016, which the union blamed on Mayor Sylvester Turner.

“The truth is, the mayor’s political and legal war on Houston firefighter families extends from City Hall all the way to the cancer wards,” Lancton said. “But for today, we are thrilled for Kevin and his family. Their win is a win for all Houston firefighters.”

Leago, who lives in Winnie and balances the schedules of his wife and young daughter to receive treatment in Houston, said he is cautiously optimistic about his victory. The city still could sue Leago in state district court, seeking to deny his benefits, much as Baytown took one of its own cancer-stricken firefighters to court.

Turner said the city has made no decision on whether totake Leago to court.

"With regard to Marty Lancton's rhetoric, I believe Houstonians and other people in this country are exhausted from how people talk negatively about each other, especially when what is being said is untrue,'' the mayor said in a statement.

The Texas Legislature in June passed a bill listing 11 illnesses covered by the presumptive cancer statute: stomach, testicular, colon, rectum, prostate, skin, brain, non-Hodgkin’s lymphoma, multiple myeloma, renal cell carcinoma and malignant melanoma. The original 2005 statute did not mention any specific types of cancer.

zach.despart@chron.com


                    IN THE COURT OF APPEALS OF IOWA

                                   No. 17-0021
                            Filed September 13, 2017

STATE OF IOWA,
     Plaintiff-Appellee,

vs.

ROBERT L. WALLACE,
     Defendant-Appellant.
________________________________________________________________

      Appeal from the Iowa District Court for Marshall County, Kim M. Riley,

District Associate Judge.

     A defendant appeals from his conviction and sentence for possession of a

controlled substance, second offense. AFFIRMED.

      Merrill C. Swartz of Swartz Law Firm, Marshalltown, for appellant.

      Thomas J. Miller, Attorney General, and Genevieve Reinkoester, Assistant

Attorney General, for appellee.

      Considered by Vogel, P.J., and Potterfield and Mullins, JJ.
                                           2

VOGEL, Presiding Judge.

      Robert Wallace appeals his conviction and sentence to one count of

possession of