 private $mysqli;

    public function __construct() {
        // CONNECT TO THE DATABASE
        $this->mysqli = new mysqli($this->DB_HOST, $this->DB_USER, $this->DB_PASS, $this->DB_NAME);
        if (mysqli_connect_errno()) {
            throw new Exception("Unable to connect to the database. Error number: " . $this->mysqli->connect_errno);
    }
    }

    public function __destruct() {
        //We are done with the database. Close the connection handle.
        $this->mysqli->close();

        echo 'DBHandler closed';
    }

    publicwe could, you know, keep this between us." "Mum's the word." "Do you have a moment?" "I've just spoken with a potential new client." "Is that right?" "Yes, he and his wife are in their 60s." "Evidently, their sex life has dwindled in recent years, and he's hoping to rekindle the lost passion." "Well, they'll have to make an appointment." "There isn't an opening for months." "I want to move them to the front of the line." "So these are VIPs, I gather." "They're my parents." "I didn't know your parents were having trouble." "Neither did I, till last week, when I ran into my father at that singles seminar." "He's dissatisfied in the marriage." "According to him, my mother is no longer interested in sex at all."


to understand." "And that's exactly what I'm doing as well, trying to understand." "Civil Procedure is a must." "You're gonna want to sign up for that one." "Every first-year law student takes it." "Well, it meets Wednesday nights, which means I can still take" "Constitutional Law Tuesday mornings." "A paralegal at my firm did the same program you're doing... part-time classes, nights and weekends." "He had his JD in six years." "I think maybe we should find a hotel, finish the drive in the morning." "Just so we're clear, when you said that Albany was" ""a hop, skip, and jump" away, what you meant was a three-hour flight followed by a six-hour drive into the middle of nowhere." "For your information, Albany is often compared to the greatis, 'cause I made it that way." "Maybe if he had the keys that night... but he didn't." "I did." "Hmm." "What you and James have now, it doesn't seem like love." "It seems like punishment." "If you stay in this marriage, Louise, this will... this will just keep happening." "Eventually, you will be right back here again." "Don't you think I know that?" "Well, then you have to leave, don't you?" "How do I do that?" "I put this man in a wheelchair for the rest of his life, and then I just walk out the door?" "You're asking me to trade one form of punishment for another." "How do you know it would be any worse than what you have now?" "I don't." "I don't." "But


Furthermore, differences in ovulatory progesterone concentrations between studies may partly result from different assay systems. The reliability of our methods applied for diagnosing ovulation is verified indirectly by the maturation stages of oocytes recovered 2 and 4 days later. On day 2 all oocytes were still in prophase-I stage, which has been shown to exist for up to 48 hours after ovulation \[[@B15],[@B16]\], whereas on day 4 metaphase-II oocytes, which can be expected the earliest 48 to 54 hours after ovulation \[[@B15],[@B16]\], were identified. Despite progesterone concentrations clearly above 47.7 nmol/L, as described by Concannon et al. (1975) \[[@B27]\] at the time of fertilization, signs of fertilization were missing probably due to a delay observed by Reynaud et al. (2005) \[[@B16]\] at least up to 83 hours afterbe required. The individual components can then be transported separately to the job site where they are reassembled.
The typical past practice has been to undeck the upper works from the lower works. This disassembly of a conventional crane can also be both labor-intensive and time-consuming, adding additional expense to the undecking and redecking operations. This is primarily due to the large number of high-strength fasteners connecting the upper works assembly to the lower works assembly.
To overcome this problem, several quick disconnect systems have been developed. Several such machine designs, many of which are patented, are disclosed in an article entitled "Solving The Quick-Disconnect Problem For Big Bearings" in the Jul. 7, 1983 issue of Machine Design. For examples of previously patented approaches to solving this problem, see U.S.


[start] ---
        if ((int)K2_JVERSION < 25) {
            $option = JRequest::getCmd('option');
            $task = JRequest::getCmd('task');
            $type = JRequest::getCmd('catid');
        } else {
            $option = JFactory::getApplication()->input->get('option');
            $task = JFactory::getApplication()->input->get('task');
            $type = JRequest::getCmd('catid');
        }
        if ($option == 'com_joomfish') {
        foreach ($variables as $key => $value) {
                    if (( bool )JString::stristr($key, 'K2ExtraField_')) {
                        $object = new JObject;
                        $object->set('id', JString::substr($key, 13));
                        $object->set('value', $value);


target.setProperty('id', 'adminform');
                        var div = new Element('div', {'id': 'K2ExtraFields'}).setHTML('".preg_replace($pattern, '', $output)."').injectInside($('adminform'));
                    });
                ");
            }

            if (($task == 'translate.apply' || $task == 'translate.save') && $type == 'k2_extra_fields') {
                 $subheader = ''.JText::_('K2_OPTIONS').'';
                } else {
                    $subheader = ''.JText::_('K2_DEFAULT_VALUE').'';
                }

                $objects = json_decode($extraField->value);
                $output = '<input type="hidden" value="'.$extraField->type.'" name="extraFieldType" />';
                if (count($objects)) {


        $query = "SELECT `value` FROM #__jf_content WHERE reference_field = 'value' AND language_id = {$language_id} AND reference_id = {$reference_id} AND reference_table='k2_extra_fields'";
                $db->setQuery($query);
                $result = $db->loadResult();

                $translatedObjects = json_decode($result);

                if (count($objects)) {
                    $output .= '<h2>'.JText::_('K2_TRANSLATION').'</h2>';
        }

            $view = $controller->getView($view, 'html');
            $view->addTemplatePath(JPATH_SITE.'/components/com_k2/templates');
            $view->addTemplatePath(JPATH_SITE.'/templates/'.$app->getTemplate().'/html/com_k2/templates');
            $view->addTemplatePath(JPATH_SITE.'/templates/'.$app->getTemplate().'/html/com_k2');
            // Allow temporary template loading with ?template=
            $template = JRequest::getCmd('template');
            if (isset($template)) {
                $view->addTemplatePath(JPATH_SITE.'/templates/'.$template.'/html/com_k2');
            }


   'plugins'
                ));
            }
            $wysiwyg = JFactory::getEditor();
            $editor = $wysiwyg->display('description', $K2User->description, '100%', '250px', '', '', false);
            $view->assignRef('editor', $editor);

            $lists = array();
            $genderOptions[] = JHTML::_('select.option', 'm', JText::_('K2_MALE'));
            $genderOptions[] = JHTML::_('select.option', 'f', JText::_('K2_FEMALE'));
          $view->assignRef('user', $user);
                $view->display();
            } else {
                $view->_displayForm();
            }
            $contents = ob_get_clean();
            $document->setBuffer($contents, 'component');
        }
    }

    public function onAfterRender()
    {
        $app = JFactory::getApplication();


      $active = $value->value;
                    }
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            }
        }

        $language_id = JRequest::getInt('select_language_id');
        $db = JFactory::getDbo();
        $query = "SELECT `value` FROM #__jf_content WHERE reference_field = 'extra_fields' AND language_id = {$language_id} AND reference_id = {$itemID} AND reference_table='k2_items'";
        $db->setQuery($query);
        $result= $db->loadResult();
        $currentValues = json_decode($result);
        if (count($currentValues)) {
            foreach ($currentValues as $value) {
                if ($value->id == $extraField->id) {
                    $active = $value->value;
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consumer device. Track data is communicated from the portable consumer device to various other devices to authenticate the transaction. Due to the limited available space in the tracks, the number of characters in a counter data field may be limited, for example, to four characters. If the consumer conducts more than 9999 transactions, then the counter data field may not be able to accommodate counter values with more than four characters long. Thus, reducing the number of characters in Track data would be desirable.
Also, an unauthorized person could potentially intercept a counter value that is present in the Track data if it is in the clear and unencrypted. If the unauthorized person knows other information that is used to create a dCVV, the dCVV could theoretically be obtainedto be self-adjoint is stronger than to be symmetric. Although this distinction is technical, it is very important; the spectral theorem applies only to operators that are self-adjoint and not to operators that are merely symmetric. For an extensive discussion of the distinction, see Chapter 9 of Hall (2013).

For any densely defined operator A on Hilbert space one can define its adjoint operator A. For a symmetric operator A, the domain of the operator A contains the domain of the operator A, and the restriction of the operator A on the domain of A coincides with the operator A, i.e. , in other words A is an extension of A. For a self-adjoint operator A the domain of A is the same as the domain of A,


The Baker County Community Wildfire Protection Plan (CWPP) is a working document that will serve as a resource for providing information to enhance community safety through hazard and risk reduction in wildland-urban int ...

An average of approximately 200,000 pounds of bay clams were harvested annually in Oregon for the years 1943-49, inclusive. The commercial harvest of bay clams is composed of the gaper, cockle, and softshell clams. The ...

This pipe was installed in 2005 by Johnson Rock Products. The culvert has aluminized weir plates welded to the inside of the pipe at 10-foot intervals. The tributary on which this culvert was installed flows into Parad ...

The report summarizes basin level accomplishments and investments related to water quality improvements, fish recovery, and watershed
health. The report also provides an overviewthe first division of the work, Heidegger attempted to turn away from "ontic" questions about beings to ontological questions about Being, and recover the most fundamental philosophical question: the question of Being, of what it means for something to be.

Heidegger approached the question through an inquiry into the being that has an understanding of Being, and asks the question about it, namely, Human being, which he called Dasein ("being-there").

He helped Blochmann emigrate from Germany before the start of World War II and resumed contact with both of them after the war.

Heidegger spent much time at his vacation home at Todtnauberg, on the edge of the Black Forest.

Heidegger also made critical contributions to philosophical conceptions of truth, arguing that its original meaning was unconcealment, to philosophical analyses of art


phone and bemoan the Germans' reluctance concerning electronic payments versus cash, Zeeck says, adding that these sectors could be improved in no time. "It should be possible to digitalize public administration systems, to make them available in English, enable fast internet and electronic payments."Bovini.

In this paper we attempt to reconstruct phylogenies between 14 extant representatives of the Bovinae subfamily. We examined 84 autosomal gene sequences, from 15 different genes, sampled over 4 Bovine chromosomes. Neighbour joining trees and the neutral substitution rate per site at synonymous (dS) and noncoding (dI) regions are presented for all autosomal sequences in an effort to identify relationships and divergence times between species, and test for evidence of introgression or lineage sorting.

Results
=======

Sequencing
----------

In total 84 amplicons from 15 genes were sequenced across 14 representatives of the Bovinae subfamily, including members of the Bovini and Tragelaphini tribes, which we used to infer the sequence from the most recent common ancestor (see Methods). From the 84 amplicons 83 amplified in at least one sample. The relative proportions from the


collected and sequenced all species and prepared the manuscript for submission. JM and MG coordinated the study and provided statistical and writing support. All authors read and approved the final manuscript.

Supplementary Material
======================

###### Additional file 1

**Supplementary table one of primers and amplification success for each amplicon in the study**. Summary of genes and exons where primer pairs have been designed for analysis and the success of each sequencing reaction.

######

Click here for file

###### Additional file 2

**Total alignment concatenated from all Exonic and Intronic amplicons spanning shortest complete read**. Multiple alignment of Exonic and Intronic nucleotide sequence from which the majority of the analysis is based.

######

Click here for file

###### Additional file 3

**Supplementary table two Aberrant allele positions and relative age**. Table summarising the position of all aberrant sites fromsampling it, so even if we’re indecisive about if we want to spend the money on that, once we touch it, we have more information. It’s not something that’s at a distance.” Don’t underestimate the impact of subtle cues, like a simple change in flooring. Going from a hard surface to the comfort of carpet can provide enough variety in touch (and sight) that Sanders says can influence a purchase. In addition to design elements that tickle the sense of sight, Verburg suggests creating clear zones with focus points and putting target retail at eye level.

She also encourages taking a holistic approach and engaging all senses at once with a consistent atmosphere: “Think about the material and colors you are using. Create mood boards—this will help you to


striving to ensure all their staff are pouring properly, going forward," said Kwasnycia.

"But there is still no word on what's going to happen with all the short pours that have happened up to this point or even if they'll be able to monitor … to ensure everyone is getting that full pour that they're entitled to."Pages

Tuesday, June 10, 2008

For the past couple days, I've been experimenting with using Bazaar and Combinator more or less simultaneously. As you may know by now, Combinator is a tool that wraps some of Subversion's ugliness (mostly merging), helps manage branches, and sets Python paths for development environments. We use it extensively (almost exclusively) at Divmod.

One of my recent side projects has evolved into useful code more quickly than I had anticipated, so I thought I'd put it up on Launchpad in the Twisted Community Code. This, of course, led to questions about one-time imports, mirroring, and dual bzr/svn management. I eventually opted for the last, using the bzr plugin bzr-svn. Not having a lot of experience with Bazaar, I was at a bit of a loss, at


are sync'ing a bzr branch with googlecode's subversion, you will need to prefix your initial push with svn:

1 comment:

I have a couple of things that I wish to mention about your post if I may.

Firstly, in order to push using "lp:whatever" you need to first run "bzr lp-login your-launchpad-id". It seems that you have done this, but I wanted to make sure it was noted for anyone that may try and follow your instructions.

Secondly, when pushing a to an svn repo you only need to use "svn-push" if you are pushing a branch that doesn't already exist in svn. bzr-svn actually makes "bzr push" work to svn. However it currently only works if the branch exists in svn already. This will be fixed at some point, at whichnorth part of central Osaka is the gigantic Osaka/Umeda train station that home to not only the JR trains, but also the Hankyu and Hanshin train lines and three very convenient subway lines(Midosuji, Yotsubashi, and Tanimachi). The station itself is a destination, especially if you love to shop. It is connected to floors upon floors of boutiques and two major department stores that always have the most beautiful storefronts, regardless of the season. This area is also surrounded by plenty of business offices and wherever you find salarymen, you will find a wealth of eating and drinking establishments. This area can be a bit overwhelming and confusing, but a five minute walk away from the station in any direction will bring you to a quiet neighborhood. One of


numbers. He realized they
were advising him to become a public accountant. He ramped up the interview schedule,
got a haircut, shaved his beard, and started making the rounds, albeit a bit later
than his fellow accounting grads.

New Year 1981 brought big changes. Chris started work for the Seattle office of Laventhol
& Horwath, the largest second-tier national accounting firm in the country, and three
weeks later became a first-time father when his daughter, Kirsten, was born. Four
years later to the day, his son, Alex, arrived.

By then, Chris was a CPA specializing in tax work, another serendipitous move, as
it turned out; although there were a few hurdles he had to clear. Laventhol in Seattle
had just merged with a smaller firm that dealt with taxation. Chris agreed to work
in the tax department and beganinstalled I would uninstall and reinstall the software you download.

where can i get another disk for it so i can download from my pc to my blackberry because my computer keeps search for the device and when it can't find it it asks me to insert the software disk which i do not have. I have the same problem in that my CD Rom drive on my PC does not work, so I cannot get the Blackberry software onto my PC via the disk. Can I download it somewhere

The best way to download pictures from your camera to your computer involves removing the memory card from the camera and plugging it into a card reader (either built-in to the computer or connected via USB or FireWire). This is


Regulation and activity of cytosolic 5'-nucleotidase II. A bifunctional allosteric enzyme of the Haloacid Dehalogenase superfamily involved in cellular metabolism.
In many vertebrate tissues, cytosolic 5'-nucleotidase II (cN-II) either hydrolyses or phosphorylates a number of purine (monophosphorylated) nucleosides through a scheme common to the Haloacid Dehalogenase superfamily members. It possesses a pivotal role in purine cellular metabolism and it acts on anti-tumoural and antiviral nucleoside analogues, thus being of potential therapeutic importance. cN-II is Mg2+-dependent, regulated and stabilised by several factors such as allosteric effectors ATP and 2,3-DPG, although these are not directly involved in the reaction stoichiometry. We review herein the experimental knowledge currently available about this remarkable enzymatic activity.Donald Trump told reporters on Saturday that the shooting at a Pittsburgh synagogue that left 11 people dead had little to do with gun laws and that had there been protection inside the temple "the results would have been different".

The shooting showed that the US should stiffen laws on the death penalty, Trump said before getting on Air Force One. "I think one thing we should do is we would stiffen up our laws with guns with the death penalty," Trump said. "When people do this they should get the death penalty."


how far Hokulea has gone since its first voyage from Hawaii to Tahiti in 1976.

Disaster befell another voyage in 1978 when the canoe capsized off the Hawaiian island of Molokai in a blinding storm. Eddie Aikau, a revered Hawaiian surfer and lifeguard on the crew, grabbed his surfboard and paddled for help, but was never seen again. The rest of the crew members were rescued.

Indigenous cultures

Crew members hope the success of the latest journey will inspire other indigenous cultures to rediscover and revive traditions. Mr. Thompson said he also hopes indigenous cultures can help with solutions to modern-day problems such as climate change.

Native Hawaiian ancestors were not only skilled navigators but good stewards of the islands who farmed and fished sustainably. “They figured it out how to liveon paper, it's a fictional place, really," the CIA veteran said, "The power doesn't lie in Sarajevo, it lies in other places, it lies with the ethnic communities, it lies with the American Embassy in Sarajevo, at least for the Federation."

Meyer believes that the best way to solve tensions in the Balkan region is to redraw its borders… once again.

"It can be, it depends on how it's done. We have already redrawn borders here. Montenegro, a very-very close vote, but Montenegro in Serbian borders have been redrawn," Meyer noted, in a reference to a controversial border demarcation agreement between Kosovo and Montenegro.

"Much of the world has recognized Kosovo," the former CIA official continued, "not everybody, five countries in the EU have not, but that is redrawing borders. And


* w_grad1
    weights2 -= learning_rate * w_grad2

# Outputting all the outputs at once.
a1_full = x_train
a2_full = np.insert(sigmoid(a1_full.dot(weights1)), 0, 1, axis=1)
a3_full = sigmoid(a2_full.dot(weights2))
print(a3_full)

Here's the output I'm getting:

I also don't understand the following:

In the coursera course, delta3 is computed by just doing: a3 - target but is other places I've seen delta3 being calculated (a3 - target) * sigmoid(a3, derv=True). I'm confused, which one's correct? and why?
In many implementations, the person did not use learning_rate and (1 / m) to step down the grad. Are the learning_rate and (1 / m) optional?
What are we supposed to do with the biases? Update them? Not update them? In many other implementations, I've seen people just updating the biases as well.
Is there a set position where the biases should be?a detailed statement of, or reference to provisions of its constitution and bylaws showing the procedure followed with respect to, (a) qualification for or restrictions on membership, (b) election of officers and stewards, (c) calling of regular and special meetings, (d) levying of assessments, (e) imposition of fines, (f) authorization for bargaining demands, (g) ratification of contract terms, (h) authorization for strikes, (i) authorization for disbursement of union funds, (j) audit of union financial transactions, (k) participation in insurance or other benefit plans, and (l) expulsion of members and the grounds therefor;
and (B) can show that prior thereto it has-
'(1) filed with the Secretary of Labor, in such form as the Secretary may prescribe, a report showing all of (a) its receipts of any kind and the sources


of such receipts, (b) its total assets and liabilities as of the end of its last fiscal year, (c) the disbursements made by it during such fiscal year, including the purposes for which made; and
'(2) furnished to all of the members of such labor organization copies of the financial report required by paragraph (1) hereof to be filed with the Secretary of Labor.
'(g) It shall be the obligation of all labor organizations to file annually with the Secretary of Labor, in such form as the Secretary of Labor may prescribe, reports bringing up to date the information required to be supplied in the initial filing by subsection (f)(A) of this section, and to file with the Secretary of Labor and furnish to its members annually financial reports inSeries 6 of the Board's Rules and Regulations was adopted, 29 CFR, 1951 Supp., 102.  For our purposes the language of Section 102.13 in Series 6 is identical with that which appears in that section in Series 5


the value of 1/((-2 + 0)/(395/55 + -7))?
-1/11
What is 2607/132 + -5 - 15?
-1/4
0 - -4 - 30972/7654
-2/43
Evaluate (-75*(-132)/(-1650))/(1 - 0).
-6
Calculate 106/371 - 52/(-14).
4
What is the value of 2/6*(108/(-24))/((-27)/(-90))?
-5
Evaluate 1 + (11 - 22) - 3.
-13
What is the value of 7 + (-1 - 4 - (-136)/(-17))?
-6
Evaluate ((-80)/25)/((-26)/(-65)).
-8
What is the value of 1075/(-645)*18/10?
-3
1/(-6) + ((-1507)/(-198) - 7)
4/9
What is the value of 846/72 - 12 - 66/(-8)?
8
Calculate 12/(-15)*(-15575)/1780.
7
What is ((-4)/(-170))/(36/84*56/360)?
6/17
What is the value of 10*((-36)/4)/54?
-5/3
Evaluate (-1 - ((-15)/6)/1)/(23/(-46)).
-3
Calculate (-6)/10*1150/(-92)*(-2)/70.
-3/14
What is the value of ((-45)/27)/(60/540)?
-15
What is -25 - ((-1)/(-2))/((-258)/3096)?
-19
What is (-2 - -8) + (16/(-40))/(123/1860)?
-2/41
What is -17 - -3*2185/399?
-4/7
Evaluate 344/43*(22 - 21).
8
48/70 + (-398)/1393
2/5
Calculate (42/28)/(-2 - 11/(-4)).
2
What is the value of 7695/(-7182) + 3/(-7)?
-3/2
What is the value of (4*2/8)/((-1425)/75)?
-1/19
(-6)/10 + 299/390
1/6
What is the value of 27 + -1 - 190/(111two men who implicated Mohammad Soleimani after they themselves were caught in possession of drugs.

Another informed source said that the Supreme Court quashed Soleimani’s death sentence in July 2016 and granted him a retrial. However, he was later re-sentenced to death after a summary retrial, which was limited to one brief session, before a revolutionary court in Karaj. In a second review of Soleimani’s case the Supreme Court rejected his appeal and upheld the death sentence.

Sources close to Ali Mohammad Lorestani told Human Rights Watch that authorities in Alborz province arrested him in October 2012, detaining him for at least 18 days at a police detention center and interrogating him without access to legal counsel. “His family had no idea where the authorities took [him],” a source said.


International oppose the death penalty in all circumstances because it is inherently irreversible and is the ultimate cruel, inhuman and degrading punishment.

Iran should reverse the death sentences against these 12 individuals and abolish the death penalty once and for all, Human Rights Watch and Amnesty International said.

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IRAN WATCH CANADA online Is managed by Morteza Abdolalian (Mori) .It is the continuation of Iran Watch bulletin (print) since 2004 .It monitors daily news about Media,journalists and human rights in Iran.It defends press freedom,freedom of expression,Freedom of Information and Human Rights Activists in Iran and around the world.It has no affiliation to any political organizations.It is illegal using Iran Watch Canada without mentioning it as the source.and a container of polymerizable 1,1-disubstituted ethylene monomer formulation is provided. According to this invention, embodiments provide a kit comprising a plurality of applicator tips and at least one container of polymerizable 1,1-disubstituted ethylene monomer formulation.
Embodiments of this invention include a coupler that connects an applicator tip to a container of polymerizable 1,1-disubstituted ethylene monomer formulation. Further, embodiments of this invention include a casing that is arranged to receive a cartridge of polymerizable 1,1-disubstituted ethylene monomer formulation and to cooperate with an applicator tip to form a polymerizable 1,1-disubstituted ethylene monomer formulation applicator.
Embodiments of this invention provide an applicator tip that may be used directly with a polymerizable 1,1-disubstituted ethylene monomer formulation container or as an attachment to an existing applicator tip. According to this invention, embodiments of


stood, chanting, “Housing is a human right.”

In recent months, homeless and low-income residents in Los Angeles and the Bay Area have cited the state’s affordable housing crisis as justification for simply taking over houses. Saturday’s attempted occupation is just the latest example.

California has an estimated shortage of 1.4 million homes for low-income families and its homeless population stands at about 151,000 on any given night — an increase of 16% from last year.

Last month, Los Angeles City Councilman Gil Cedillo proposed using eminent domain to force a landlord in Chinatown to sell his building. Cedillo’s proposal came after tenants protested a plan for the building to switch to market-rate rentals following the expiration of an agreement with the city to keep rents low. His effort is awaiting aand portrayed by some as a successful act of civil disobedience.

The protesters sent a letter to Newsom on Saturday morning, asking for his direct assistance.

In response to the broader homelessness crisis, Newsom has, among other actions, allowed state-owned travel trailers to be used as temporary homeless housing and offered state property to local governments for use as shelters and other solutions.

The protesters said their actions were aligned with the governor’s call to turn public property into homeless housing. But they maintained that Newsom and other elected officials needed to do more and work faster to get people off the streets and into stable housing.

The governor’s office did not respond to a request for comment.

“There’s so many vacant homes while there’s people on the streets,” Escudero said. “He should


Speaking to Daily Telegraph, Harry said that opening up about his own mental health struggles on her podcast ‘Mad World’ inspired him to team up on the new project with Oprah.

Speaking to Daily Telegraph, Harry said that opening up about his own mental health struggles on her podcast ‘Mad World’ inspired him to team up on the new project with Oprah.

Prince Harry said he hopes it will show examples of “human spirit fighting back from the darkest places”. He added that he was “incredibly proud to be working alongside Oprah on this vital series, which we have been developing together for several months”.

Speaking to the paper, the Duke said:

When I did your podcast two years ago the response made me realise what an impact sharing my story couldBroken (Elisa song)

"Broken" is a song written by Italian adult alternative singer Elisa from her fourth studio album, Lotus (2003), it was released on 24 October 2003 as the album's lead single. The song was also includes in the Greatest hits Soundtrack '96–'06.

Music video
The music video for the song was filmed in October 2003 by Luca Guadagnino, the video shows Elisa and her band.

Track listings
CD-EP
"Broken" – 4:20
"(Sittin' on) the Dock of the Bay" – 2:52
"Redemption Song" – 5:23

Chart performance

References

External links

Category:2003 singles
Category:Elisa (Italian singer) songs
Category:Songs written by Elisa (Italian singer)
Category:Rock ballads
Category:English-language Italian songs
Category:2003 songs


company's support for community involvement has
led to its hosting the Cornell Club of Buffalo's annual fundraiser in the soaring glass atrium at its headquarters. In
addition, Malchoff, who comes from a Cornell family (his father, Godfrey "Doc" Malchoff '43, as well as his brother,
son, and daughter-in-law are also graduates), has also been able to fit his volunteer efforts for the university into
his busy schedule. They include serving on the Cornell University Council and on the advisory council for Cornell's
undergraduate business program.

Not surprisingly, APR and S. C. Johnson & Son, Inc. also see community involvement as a family-company value and champion
it among their employees.

Todd Schnuck, MBA '83, President of Schnuck Markets, Inc.

And Schnuck Markets Inc., another family-owned business with Johnson School links, recently won the Right Arm Award
for its commitmentthe returned package will be returned to you.
2. Please indicate reason for return to get the return authorization., And back-to-back address
3. Pack merchandise securely. Please include the following information with your return: bill-to name, address, ship-to name, address, order number, reason for return
.
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*** 20% handling fee will be deducted from the refund.
*** If the items is Non-quality problems, customers have up to 20% postage for exchange shipping costs


The so-called “Evil May Day” riots, marked by attacks on foreigners and on their places of residence and of business, took place in the City of London on and around May Day 1517, following an inflammatory speech by a Dr Beal or Bell at St Paul’s Cross, inciting the crowd “to cherish and defend themselves, and to hurt and grieve aliens for the common weal”. At the time there was considerable popular resentment towards foreigners in general and foreign merchants in particular, on account of their perceived preferential treatment by City authorities. The riots were eventually broken up only after thousands of troops were called in and hundreds of rioters taken prisoner. The ring-leaders were then more or less immediately hanged, drawn and quartered, and their remains gibbeted.Ann Ree Colton stemmed from her spontaneous answers to his every question without the need to go into trance. Her chief student, fellow teacher, and husband of 31 years, Jonathan Murro, co-wrote her biography/autobiography.

Starting in 1951 she began expounding on wide range of ideas. She felt that she needed to move from working with individuals to working in a more impersonal manner, to bring her ideas of a complete system to a broader audience. She said this system, Niscience, came from an actual heavenly, spiritual blueprint she called an archetype. These archetypes, she said, are not the archetypes described by Carl Jung.

The system of Niscience is extensive and covers many spiritual practices, such as meditation, the speaking of mantrams, dedicated fasting, mandala creation, spiritual movement, and dream research,


that: $\mu-\overline{X}$ does not depend on the index $i$ in the sum and thus can be taken out of the sum.
In other words, $\sum_{i=1}^n2[(X_i-\mu)(\mu-\overline X)]$ can be re-written as:
$$2(\mu-\overline X)\sum_{i=1}^n(X_i-\mu)$$
Now, use the fact that $n \overline{X} =\sum_{i=1}^nX_i$ and simplify.

lift the pan, tilt and rotate to distribute the sauce. You never, ever pushed it around with the ladle. You didn't need to if it was the right consistency and you used the right amount.

The next thing to go on was the mozzarella cheese. Ken used sliced mozzarella. There were precise guidelines for how to place it. The 13" size got two slices end to end across the middle, so we can assume the slices were just over 4" x 6". You then put one slice above and below the centred ones and then you cut a fifth slice in half at the middle and then each half diagonally with a pizza cutter. These triangles filled in the corners. I am convinced the sliced cheese is another secret


Ken's with a 12" circle of ingredients. It wouldn't cook right if you didn't get everything to the edges, leaving only that half inch or less of exposed crust sloping up the edge of the pan. We were obsessed with making them perfectly and lazy preppers shaped up and did it right or were sent to wash dishes.

Once in the oven, the pizza chef gave them about 3-4 minutes, at which point that edge of crust showing would start to puff. You had to catch it before it began to dry out. Too soon or too late and the next step didn't create that firm edge that makes such a great handle when eating a slice of Ken's Pizza. We used a special pan pliers to pull thethe other ingredients were. Most importantly though was the interaction of the sauce and the cheese as it got golden brown and gave up both it's moisture and stringiness. A properly cooked Ken's pizza slice did not trail strings of cheese when you cut or bit it. I've never had pizza as good as Ken's since I moved away from Oklahoma.

I hope someone figures out how to replicate it or I find an excuse to go back to Oklahoma and indulge in a Ken's pizza soon. My wife is sick of hearing about them and not getting to have one!

I used to work at Ken's Pizza in Jenks, OK and at one on S. 33rd W. Ave. at West Skelly Dr. (I-44) in Tulsa and finally at one


Why Republicans will continue to lose

Joseph Cotto, writing for the Washington Times, states that Republican Ken Cuccinelli is a “textbook case of ideological zealotry.” Because Cuccinelli “took up with the fundamentalist Christian-dominated religious right,” Cotto declares, Virginia’s attorney general is not “fit” to be elected Virginia’s governor.

Cotto’s line of thinking reflects that of many who belong to the Republican Party these days. He doesn’t make a logical argument, and his views are representative of the GOP’s problem.

“Radical Republicans cannot win outside of select constituencies,” Cotto declares. The truth is, however, that Cuccinelli lead in the polls throughout the summer and until the liberal media managed to pin the government shutdown (which affected a lot of government workers who reside in Northern VA) on Cuccinelli and fellow Republicans. Ininformed consent was obtained from all participants.

Symptom severity score
----------------------

The primary outcome for this analysis was ARI symptom severity score, which was assessed at (and reflected symptom severity at) the time of the enrollment interview and before any RT-PCR results were disclosed. Symptom severity score was assessed using a subjective self-rating of eight symptoms, including two upper respiratory (nasal congestion, sore throat), two lower respiratory (cough, wheezing), and four systemic symptoms (feverishness, fatigue, headache, muscle aches). Participants rated each of their symptoms on an ordinal scale that included response options of absent (0), mild (1), moderate (2), or severe (3). These symptom ratings were summed to create a symptom severity score with a possible range of 1--24 points, where higher scores indicated greater perceived severity of symptoms. All participants


*/
  using InputVectorType = Vector<TParametersValueType, Self::InputSpaceDimension>;
  using OutputVectorType = Vector<TParametersValueType, Self::OutputSpaceDimension>;

  /** Standard covariant vector type for this class */
  using InputCovariantVectorType = typename Superclass::InputCovariantVectorType;
  using OutputCovariantVectorType = typename Superclass::OutputCovariantVectorType;

  /** Standard coordinate point type for this class. */
  using InputPointType = Point<TParametersValueType, Self::InputSpaceDimension>;
  using OutputPointType = Point<TParametersValueType, Self::OutputSpaceDimension>;

  /** Standard vnl_quaternion type. */
  using VnlQuaternionType = vnl_quaternion<TParametersValueType>;

  /** Standard vnl_vector type for this class. */
  using InputVnlVectorType = typename Superclass::InputVnlVectorType;
  using OutputVnlVectorType = typename Superclass::OutputVnlVectorType;

  /** Versor type. */
  using VersorType = Versor<TParametersValueType>;
  using AxisType = typename VersorType::VectorType;
  using AngleType = typename VersorType::ValueType;
  using AxisValueType = typename AxisType::ValueType;

  /** Get offset of an Rigid3DPerspectiveTransform
   * Thisfor not signing an agreement sooner, but he said the deal that Greece was offered was not made in good faith – or even one that the Troika wanted completed. In an hour-long telephone interview with the New Statesman, he called the creditors’ proposals – those agreed to by the Athens government on Friday night, which now seem somehow generous – “absolutely impossible, totally non-viable and toxic …[they were] the kind of proposals you present to another side when you don’t want an agreement.”

Varoufakis added: “This country must stop extending and pretending, we must stop taking on new loans pretending that we’ve solved the problem, when we haven’t; when we have made our debt even less sustainable on condition of further austerity that even further shrinks the economy;


is little reason to worry about that happening. However, with the majority of construction taking place in 2017/18, and £430m been spent prior to this season, stadium expenses will surely rise well above the initial estimations of £750m.

Financial Forecast

With Spurs announcing record profits, they have set themselves up for a very stable financial future, especially with all revenue streams aside from the Champions League locked in for the foreseeable future. With that said, Spurs still have some additional significant revenue escalators to look forward to.

As I mentioned earlier, this newest report covers the first two significant revenue boosts: the new PL TV deal (worth a £55m increase) and the CL revenue (while not guaranteed, was worth £25m last year, and will increase significantly next year).

The next two escalatorsbefore placing the art piece....

Theme of the house is a part that is important and it is essential to consider. You need to customize the home theme with a kitchen theme in your minimalist home. For example a kitchen with a classic theme, vintage or retro you can decorate with floral patterned curtains with...

The interior area of the room with the most curtains is the living room. We often see the curtains installed in the window although there are also installed on the door or as a place of separation between rooms....

Because both emphasizes comfort and functionality, use furniture that is small and compact. The use of small furniture is able to make the interior of the kitchen and dining room japandi look more spacious, giving flexibility to


JSLint logic obtained the settings file from (JSLintOptions.xml).

Locating JSLintOptions.xml proved somewhat difficult at first, as it was tucked away hiding in the Roaming section of my user folder on Windows (\Users\*\AppData\Roaming\). These hacks could greatly benefit from some re-factoring effort if I have ever have the time, or someone else is so inclined. But after an initial attempt to refactor out the most core of logic things fell apart in the land of SDK dependencies, so I rolled back and opted for a less elegant approach which was the 2 hacks listed above.

The logic for the console application is then trivially simple:

Read .js files.

Using the JSLinter class method Lint() supply the .js file content/

Write errors to console

Return error code, 0 (Success), 1 (JavaScript warnings), etc.

Show me the code!

Ifpeople interested in cooking, the above measurement may be too biased towards personal risk and not content, and may thus be of little use. Hence, for a group such as a cooking group, it may desirable that trust be biased towards data relevance, or the quality of recipes. Trust may have multiple components or factors, and a factor of trust which is based on the group's interests and/or group content relevance, may be important.
Prior art implementations for certificate distribution, such as SSL and TLS, typically require certificates to be signed by recognized, trusted certificate authorities to both establish identity, and exchange public keys for public-key algorithms such as RSA and Diffy-Hellman. In a peer-to-peer network, it may be undesirable to require every participating peer to acquire, i.e., pay


for, a Certificate Authority signed certificate in order to implement, for example, peer-to-peer TLS. In some embodiments, peer-to-peer zero-dollar-cost certificates may be desirable.
The ability to move one's private security environment from device to device may be desirable. For example, having multiple identities may be confusing and may add unwanted complexity to a security model. Since a private security environment may include information such as a user's private key, trusted root certificates, and peer group credentials, it may be desirable for mobility to be under the constraints of strong security. If a private key is no longer private, one's security environment, and all of the associated relationships may need to be recreated from zero.
The IETF's (Internet Engineering Task Force) SACRED Working Group is working on the standardization of aQ:

Riesz–Markov–Kakutani representation theorem for compact non-Hausdorff spaces

Let $X$ be a compact Hausdorff topological space, and $\mathcal C^0 (X) = \{f:X\to\mathbb{R}; \ f \text{ is continuous }\}$. It is well known that for any bounded linear functional  $\phi: \mathcal C^0(X)\to\mathbb{R},$ such that $\phi(f)\geq 0$ if $f\geq 0$ ($\phi$ is called a positive linear functional), then there exists a unique regular Borel measure $\mu$, such that
$$\phi(g) = \int g\ \mathrm d\mu, \ \forall \ g\in \mathcal C^0(X).  $$
This result follows from a direct application of Riesz–Markov–Kakutani representation theorem.
If we drop the Hausdorff hypothesis (only assuming $X$ as compact topological space). Then we can lose the uniqueness of the measure that represents the linear functional. A famous example is the compact topological space "$[0,1]$ with to origins". In this


– Medea Benjamin, American activist, founder of Code Pink
  1952   – Vic Toews, Paraguayan-Canadian lawyer and politician, 48th Canadian Minister of Justice
1953 – Amy Irving, American actress
  1953  – Pat Cadigan, American science fiction author
  1953   – John Thurso, Scottish businessman and politician
1954 – Jackie Ashley, English journalist
  1954   – Lorely Burt, English politician
  1954   – Don Wilson, American kickboxer and actor
1955 – Pat Mastelotto, American rock drummer
1956 – Johnnie Fingers, Irish keyboard player and songwriter
1957 – Kate Burton, Swiss-born British actress
  1957   – Carol Decker, English singer-songwriter
1958 – Chris Columbus, American director, producer, and screenwriter
  1958   – Siobhan Fahey, Irish singer-songwriter and producer
1959 – MichaelBANGALORE: Amid prolonged uncertainty over the fate of the BJP government in Karnataka, a new single bench of the Karnataka high court on Wednesday is hearing the petitions filed by 11 rebel BJP MLAs challenging their disqualification from the state Assembly.The case has come up before Justice V G Sabhahith after the court delivered a split verdict two days ago on the petitions.In a twist to the case, Chief Justice J S Khehar and Justice N Kumar had on Monday differed on the provisions of Para 2 (1) (a) of the 10th Schedule of the Constitution that deals with disqualification of members of a legislature, TimesNow said.Khehar upheld Speaker K G Bopaiah 's order disqualifying the 11 MLAs but Kumar set it aside in their 166-page order and


appeared after delivery of the sound stimulus. The participants were given 800 ms with a presentation of a red square to decide either pressing the key or not. Then, a feedback sign (either “a circle,” which means a correct sign in Japan, or “a cross” representing a false sign) was displayed on the monitor. A Key-press before presentation of the red square brought a warning sign and the response was a null and void, and then, the trial was repeated. Correction trials were introduced as the same as Experiment 1. ITI was 400 ms.

When the correct response rate reached 80% in the last 50 trials, the test period began immediately without notice and probe trials were randomly interspersed among the normal training trials at 10% probability. In thisThis inspiring documentary presents three amazing economically responsible farms in the USA and Canada. Their unique business plans eliminate the middle man, use sustainable methods and few fossil fuels, and show a decent living can be made! These new farming practices avoid the destructive trap of industrial food production and its financial burden.

With the participation of Ban Ki Moon, the Secretary General of the United Nations and leading USA environmentalist, author and educator, Bill McKibben, this documentary provides critical information to develop an enduring, local food network in a time of climate change.

License Options:
-Colleges,Universities, Businesses and Government:
$225 (includes Public Performance Rights)
-K-12 Schools, Public Libraries: $89 (includes Public Performance Rights).
-Public Library: $49 (Circulation Only).
-Permission to screen in public for one day: $80 (includes DVD with the right to screen


other employers and sign the Time To Change Pledge. They’ll even help you put an action plan together.

Managers might also need to specialist training to have conversations with staff about their mental health. Again, Time To Change can help.

An open culture

It’s crucial that all the above is backed up with a genuinely open culture that provides the space and time for staff to talk and mangers to listen.

The stigma that ‘bottling up’ and ‘soldiering on’ is what’s best is still something that has to be overcome. Creating a working environment that encourages openness and dialogue, with fixed meetings for these discussions, is crucial to breaking this down.

Sanctus, is a start-up which wants to change the perception of mental health in the workplace. The founder, George Bettany, gave usU.S., and after meeting with state and Delaware County officials, we quickly recognized that their organization and personalized support exceeded that of many other states," said Federico Sbettega, owner and INOX Board of Directors member. "We want to be part of a welcoming community like Delaware County, and we find tremendous value in the state and community investing in their futures; and that is exactly what we saw from the leaders in Indiana.”

Established in 1989, INOX has a group of business units around the world specializing in the forming and wholesale distribution of steel. Once operational, IMNA will receive raw roll stainless steel coils and cut and form the steel for various uses. The company will deliver high quality, Class A austenitic, ferritic and low nickel stainless steel


ionization is typical of HII regions. In particular the internal extinction correction due to the galaxy dust has been taken into account measuring the Balmer decrement in each spaxel, and assuming an intrinsic $\rm H\alpha$/$\rm H\beta$=2.86 and the @CCM1989 extinction law . We then used the pyqz code [@Dopita+2013] to derive both the ionization parameter q and the gas metallicity through the comparison with a set of photo-ionization models (MAPPINGS IV). In particular, we used the \[NII\]6583/\[SII\]6716,6731 vs \[OIII\]5007/\[SII\]6716,6731 indicator, given that the \[OII\]3727 doublet lies beyond the MUSE spectral range, and that $\rm H\beta$ is prone to uncertainties in the subtraction of the stellar contribution. The systematic errors introduced by modeling inaccuracies are usually estimated to be $\sim$0.1-0.15 dex, whereas discrepancies of up to 0.2 dex existestimated from its luminosity and simple assumptions on the stellar populations by @Finkelman+2011, and is $\sim 3 \times 10^9 M_{\odot}$, smaller than that of JO171 ($1.1 \times 10^{10} M_{\odot}$).

At odds with the Hoag’s galaxy, JO171 shows extended tails towards the north characterized by ionized gas and ongoing star formation: while the Hoag’s galaxy is isolated, JO171 belongs to a very active and rich galaxy cluster whose intracluster medium exerts a ram pressure force that creates the tails of stripped gas to the north.

As a consequence, its ring is clearly asymmetric in terms of the stellar populations/gas properties: the stripping of gas by ram pressure has caused the south-western part of the galaxy to be devoid of gas and, as we will see in §3.3, of ongoing star formation.


gathered a bookful of useful advice from his own research and in the collections of others. Fadiman promotes guided sessions, where a guide accompanies the voyager. (I used that method myself.) This new manual supplies very practical advice on how to attain the goal listed in its subtitle: Safe, Therapeutic, and Sacred Journeys. And it covers other psychedelics besides acid, although less deeply. Another bonus: it is helpful for either the guide or the voyager.

A cool tool can be any book, gadget, software, video, map, hardware, material, or website that is tried and true. All reviews on this site are written by readers who have actually used the tool and others like it. Items can be either old or new as long as they are wonderful. We postQ:

How to extract all key frames from a video clip?

I'm trying to extract key frames from a video clip. I tried the following command, but it extracts all frames.
ffmpeg -vf select="eq(pict_type\,PICT_TYPE_I)" -i 2.flv -vsync 2 -s 73x41 -r 30 -f image2 thumbnails-%%02d.jpeg

A:

You can make this simpler using -skip_frame without the need for select video filter:
ffmpeg -skip_frame nokey -i 2.flv -vsync 0 -r 30 -f image2 thumbnails-%02d.jpeg

A:

Example using the select and scale filters:
ffmpeg -i 2.flv -vf "select=eq(pict_type\,I),scale=73x41" \
-vsync vfr -qscale:v 2 thumbnails-%02d.jpeg

A few tips:

Filters should not come before the -i option, as they're an output option. I don't know where exactly you got the command from, but PICT_TYPE_I does not exist –  it should be I.
In the scale filter you can replace 73 or 41 to have the filter


automatically calculate the width or height to preserve aspect ratio: such as scale=73:-1 or scale=-1:41. This prevents stretching or squishing that can result from "forced" scaling.
Output quality can be controlled with -qscale:v (or the alias -q:v). Effective range is a linear scale of 2 to 31 and a lower value is a higher quality.
That your ffmpeg allows a filter before the input tells me it could be outdated. Download a recent static build for your operating system, or build it yourself according to the compilation guides if the above does not work.

was easy to come by, and the rest of the world was contemplating similar [emissions control] measures,” she said. “Since then, we’ve lost 1.4 million jobs in California, and the economy has taken a real dive. Now is not the time for such an ambitious regulatory effort.”

At a recent Tea Party event open to the public in Ventura on Oct. 5, a room full of conservatives and Republicans unanimously raised their hands backing Proposition 23.

“We can’t talk about green until we get out of the red,” said one activist from the back of the room.

Beyond the television adsBoth sides in the Proposition 23 campaign have “gone negative” early and often in their television advertisements.

Prop. 23 supporters argue that AB 32 is a “job killer” that will cost California


a Lambda that is continuously processing stream updates, I'd suggest going with LATEST.
Also, since you "need to use the N last updates to compute an update in Table2", you will have to query Table1 for every update, so that you can 'merge' the current update with the previous ones for that device. I don't think you can't get around that using TRIM_HORIZON too.

respiratory motion and were fit to a mono-exponential function to derive T~2~ maps of the whole left-ventricular myocardium.

Results
=======

Ex-vivo myocardial T~2~ values of the proposed approach (3D FB MoCo) were not different from standard 2D approaches (all p\<0.05): 48.7±0.9 ms (3D FB MoCo) vs. 48.2±0.6 ms (2D spin echo) and 47.5±0.8 ms (2D T~2~-prepared bSSFP (T~2~-prep bSSFP)). In healthy volunteers, compared to 3D FB MoCo and 2D BH, myocardial T~2~ maps, 3D FB Non-MoCo T~2~ myocardial maps showed longer T~2~ values (p\<0.05), larger coefficient-of-variations (COV) in T~2~ (p\<0.05), and lower image quality (p\<0.05). Conversely, the mean and COV in myocardial T~2~ and image quality of 2D BH and 3D FB MoCo T~2~ were not different (p=0.99, p=0.74, p=0.14, respectively). In canines with rAMI, edema volumes measured from 2D BH


be?" Rendering to IE, Chrome, Safari, Word, and PDF was an exercise in frustration and compromise, especially considering that Visual Studio and Report Builder were also different. In all cases, the height and width of the text boxes changed, the font size changed, and the spacing around the text changed.
Our technique was to prioritize the various output formats, then find settings that produced the best output based on those priorities. Given this, users see better (but still not quite perfect) results than we see in Visual Studio.

P < 0.001) and smear-positive (AOR: 0.17, 95% CI: 0.04-0.65, P = 0.009) were negative factor for cured and completed. However, hospitalization during initial period of treatment was positive factor (AOR: 7.92, 95% CI: 1.73-36.2, P = 0.008). After inpatients DOTS introduction, the rate of cured or completed increased from 50% to 67%, and the rate of failed or defaulted decreased from 46% to 22% (P < 0.05). TB patients from Hanba, a kind of dormitory housings for construction workers, occupied 3.8% of total TB patients in Chiba City. Higher rate of defaulted or failed cases leads to poor treatment outcome in TB patients of Hanba construction workers who were possibly associated with an elevated risk of urban tuberculosis. DOTS might improve adherence to treatment and result in


switch out the gridview entirely for simple text, bound to a boolean or something that checks if the user is logged in
Thanks in advance for any input

A:

A very easy way to accomplish this is to overlay a grid on the GridView and only show if it the user is not logged in. You would take advantage of a BooleanToVisibilityValueConverter for this.
<Grid Style="{StaticResource LayoutRootStyle}">
    <Grid.Resources>
        <converters:BooleanToVisibilityConverter x:Key="BoolToVis"/>
    </Grid.Resources>
    <Grid.RowDefinitions>
        <RowDefinition Height="140"/>
        <RowDefinition Height="*"/>
    </Grid.RowDefinitions>

    <GridView
        x:Name="itemGridView"
        Grid.Row="2"
  # © 2016 and later: Unicode, Inc. and others.
# License & terms of use: http://www.unicode.org/copyright.html#License
#
# File: Taml_Beng.txt
# Generated from CLDR
#

::[\u0BE6\u0B82-ஃஅ-ஊஎ-ஐஒ-கங-சஜஞ-டண-தந-பம-வஷ-ஹா-ூெ-ைொ-\u0BCDௗ௧-௲ஶ];
::NFD;
::Tamil-InterIndic;
::InterIndic-Bengali;
::NFC;


with a more robust provisional agreement that addresses, say, military activities within exclusive economic zones and perhaps even the regional naval arms race. That, of course, would be very difficult to achieve, but a lengthy negotiation process could be justified by the end goal of regional stability.

Finally, Singapore should call for the establishment of a South China Sea Arbitration Court, with a rules-based procedure based partly on the processes of UNCLOS. China could dismiss Singapore as a gadfly, but it understands better than anyone that having Singapore drive the process would provide it with a better outcome than having its claims contested in The Hague. China knows it can negotiate a better deal within the region with Singapore at its helm. Singapore’s close cultural and linguistic ties toimport numpy as np
import pytest

from sklego.common import flatten
from sklego.linear_model import LowessRegression
from tests.conftest import nonmeta_checks, regressor_checks, general_checks

@pytest.mark.parametrize(
    "test_fn", flatten([nonmeta_checks, general_checks, regressor_checks])
)
def test_estimator_checks(test_fn):
    lowess = LowessRegression()
    test_fn(LowessRegression.__name__, lowess)

def test_obvious_usecase():
    x = np.linspace(0, 10, 100)
    X = x.reshape(-1, 1)
    y = np.ones(x.shape)
    y_pred = LowessRegression().fit(X, y).predict(X)
    assert np.isclose(y, y_pred).all()


too late this year, but I just decided to go for it.

“Christmas for me is just like any other day. I don’t have any kids or anything so I spend it with my mum, we have a meal and then fall asleep in front of the TV. This year will be a lot different and we’re looking forward to it.”

Within just a few hours of sharing a post on Facebook explaining her idea, it had been seen by 20,000 people.

Jen said: “What I love about Paisley is that everybody either has asked to donate money or food for the meal.

“Some people have even asked if they can come along and help on the day and others have donated money. I’ve been inundated with stuff which has been fantastic.04/2010
 2011 Kunstwerkstatt - Axel Krause (artist book), Prestel Verlag

References

Category:1958 births
Category:20th-century German painters
Category:21st-century German painters
Category:German contemporary artists
Category:German male painters
Category:Living people
Category:People from Halle (Saale)


Q:

Calculating quantiles without storing

I wrote c++ code to calculate 119 quantiles (from 10^-7 to 1 - 10^-7) of 100 millions of double precision numbers.
My current implementation stores the numbers in a vector and then it sorts the vector.
Is there any way to calculate the quantiles without storing the numbers?
Thank you
ADDENDUM (sorry for my English):
Here is what I'm doing:
1) generate 20 uniformly distributed random numbers in [0, 1)
2) I feed those numbers into an algorithm that outputs a random number with unknown mean and unknown variance
3) store the number at step 2
repeat 1, 2 and 3 100 millions of times (now I collected 10^8 random numbers with unknown mean and unknown variance).
Now I sort those numbers to calculate 119 quantiles from 10^-7 to 1 - 10^-7 using the formulain the DNA, which produces a change in the amino acid due to the nucleotide change, but does not affect the function. However, missense, nonsense, and frameshift changes are types of nonsynonymous mutations that all generate a significant change in the protein. In recent years, a few researchers suggested that deleterious nonsynonymous single nucleotide polymorphisms (nsSNP) of GSTs are associated with diseases. One study \[[@B14-ijerph-13-00379]\] discovered that five (GSTA3/R13W, GSTA3/Y147D, GSTM3/R191L, GSTM4/R18L, and GSTT1/W101R) of 237 nsSNP were identified as potential target mutations that induced structural changes and possibly alter the detoxification process that could lead to carcinogenesis events ([Table 3](#ijerph-13-00379-t003){ref-type="table"}).

It has also been recognized that there are modifications in enzymatic activity of a missense categorized SNP in GSTP1 (rs1695/Ile105Val) at residue 105 that leads to miscellaneous diseases


          \[[@B61-ijerph-13-00379]\]
  COSMIC cancer database   Somatic mutations in cancer          <http://cancer.sanger.ac.uk/cosmic>          \[[@B62-ijerph-13-00379]\]
  dbGAP                    Genotype, Phenotype                  <http://www.ncbi.nlm.nih.gov/gap>            \[[@B63-ijerph-13-00379],[@B64-ijerph-13-00379],[@B65-ijerph-13-00379]\]
  dbSNP                    SNP            cancer                                  Air pollutant, Smoke, Platinum, Carcinogen   GSTM4, GSTP1, GSTO2, GSTZ1       \[[@B49-ijerph-13-00379],[@B57-ijerph-13-00379],[@B59-ijerph-13-00379],[@B94-ijerph-13-00379]\]
  Prostate cancer                                         Misc. Carcinogen and Toxin                   GSTP1


or deep side of the basement membrane. Examples of connective tissues that are positioned on the abluminal side of the epithelial basement membrane are the submucosa of the intestine and urinary bladder, and the dermis and subcutaneous tissues of the skin.
The present invention provides devitalized tissue regenerative compositions comprising an epithelial basement membrane as part of a matrix or scaffold for tissue repair or regeneration. The inclusion of the epithelial basement membrane in devitalized mammalian tissue regenerative compositions results in improved in vivo endogenous cell propagation and tissue restoration as compared to submucosal matrices described above which do not include an epithelial basement membrane. For the purposes of this invention, devitalized means acellular or substantially acellular. For the purposes of this invention, epithelial basement membrane means at leastDéfaite, calling for France to join Hitler's New Order. He fled to Switzerland just before the liberation of Paris by the Allies. Jouvenel was among the very few French intellectuals to pay respectful attention to the economic theory and welfare economics that emerged during the first half of the 20th century in Austria, Italy, the United Kingdom, and the United States. This understanding of economics is shown by his work The Ethics of Redistribution.

Dennis Hale of Boston College has co-edited two volumes of essays by Jouvenel.

Later in his life, Jouvenel's views shifted back to the left. In 1960, he complained to Milton Friedman that the Mont Pelerin Society had "turned increasingly to a Manichaeism according to which the state can do no good and private enterprise can do


          FOR THE SECOND CIRCUIT

                                         SUMMARY ORDER
     RULINGS BY SUMMARY ORDER DO NOT HAVE PRECEDENTIAL EFFECT. CITATION TO A SUMMARY ORDER
     FILED ON OR AFTER JANUARY 1, 2007, IS PERMITTED AND IS GOVERNED BY FEDERAL RULE OF
     APPELLATE PROCEDURE 32.1 AND THIS COURT’S LOCAL RULE 32.1.1. WHEN CITING A SUMMARY ORDER
     IN A DOCUMENT FILED WITH THIS COURT, A PARTY MUST CITE EITHERthen so,flatleriag in-his re arksxahoat UcaJI
AU religious notices will be .. .gntui.in"lt1. a )young ,, yet. Scott ;
lIT: eommuntcation.will the more difficult are both her parents that they think almost every body fit to "I see that John,!! 'said: ;,Mary "1 find for which, another of then aHa ?T' ,S

grAil l admuuaUe.. adrerti!*personal' nentR.ICT and'herself in the choice of her husband, teach. The true end of due tion is to that you are mOl' than,half SEAS_OVER." reprimanded' 'him: "MichaeL Miiliwlustgo .
. lie""I nf All
the owld .
cJtti""F1 01'the wnr ns be addressed la one is'too tall, the other too short,. 'thisis ture. Its office is to call forth powers to a'strip of read cloth in the shape ota never.to, ,' ill religion leKs as :4k',

rr: All T k rnmmunH"a'.o


not to fecnpg to 'be angry, "Jonn, you are business to an issue. He weat te ...

t to you for publication-let those who she had"at onetime or'other discarded. receive passively a few wordsdales, ; and( gelling'to be very rude;you would not clergyman.and requested that .&M ....:

.. intend embarking for "le pays du marriage Harriet began to be set down for an Old facts, but'to be active for,the acquisition think of doing that before you volun- marriage should be, publitbed,, e.r"f

. set yet ; and she herself lamented in private should inspire a profound love of trutKf *|rha-tha Me-that's a.factMary," brought her .ears, she was filled wkh

JI.. tide arc propitious. It seems that n .a portion which is ,not a natural and to teach the processes of'investigation. said he-and diacriIRiaati ..'..
[ Miss Berry her-- fife, .
against "I want'to
the slightest imputation swear my your'worship. by the, terrible tire of the ,enemy,.three
dangerously-deep in love. he chose to and yet she is getting to be an 'oldmaid.1 ." *, drummer boys quairelling for a single one who can assist him ia hie i '..

\1. the matter off and the next morning l *> .Iagistrate.-Against whom J lighten his sorrows, purify hkje; ,, ..;
all them.l Soonthe
... laugh drum that was left to .
,
his sad ,
principles eJ
.. .
strengthen .
.
the uncle but look : .
about
'True AppIicant-Looking carefully)
'I sent the bride the following: replied ; ,- two stronger ones went to_'fisticuffs,1while his children. A woman of the leaner:
:Cit KI'lTilALANIUM.: you,brother, the grand point in every Against imy wife. / the third quietly folded


sorrow what 1 about to her from the gin bottle.' directed him' find meat
:... : Mjnd am. say parate his name, and to' ing was met by the hostler, whea
*
At l will I,I'm in b..le.t this time
,: Ami)00.11 di ijtihr as well untbo mot row. You are no longer Miss Selwood;>> but M.-Lock it away from her.' the close of.the battle, ,but 1 never thus addressed: Boy. extricate thftt

I, TI.- I hurrir l a!<>ng on my track, childless widow; you had the mis- M,-Don't let her have any money. [ .At this moment Mr --- ,one of him, denote him an adequate'..,,11 efnutritions :: Sa
Hut lliatNrry my Inborn mill haunted, fortune 'lose husband, Col.Lum- A.-She keeps all the cash. the merchants of '
14. Ai l.4irn I turned Inand further tellers. This will be,it is said,the first (

I tq; SL terifrom :Lt. jtiDOELV' of the 11th. u1t.itho .. opponents out of his bvvn pocket.A .- .in discharging. the duties of. the'tr st. uniting the diflerent portions: of the instance in which the scat of an U. S. )
} I.' State in the ,
:E r4i1 fdes ;ibetb.c'grnrc., worthy 'wrlter' m the Sentinel feels) 'Tele4.in, ,Hl y exertions .with a well support of democratic principles Senator has'been contested.

. fixed, ar jhe-whole,painted black, in the. unanimous. nomination of llcLnneIt was ratified on the 17ib,
arc cotjld: not be: 'obtained other wise than excellent! ; Address arid'Resolutions; of (
Appropriate ead and foot boards are Mr. WILLIAM A. .K.i 'andtire and on the same evening .comman
by oir.iitimizg the form of a'State the


ston.The .Charles,T. Torrey admitted, Were -, .

people though they reap the benefit, ,- Dixon, Douglass ,important, document wax-signed died, that he aided in the deIf8- '

ask, wouldve contribute more for that term of five years ; and ) H., Sims. Strong,. : did monument, to Sir Robert' Pcclr t by OH futility n. if N*,* o,for adjclsaraa Adtnioia- I
.
which from its nature is trifling ami at the end of the last Towns, Tredivay- ::means (p pny'.subscrfptfons through tratnr..OIJ f.UO": } taJrt.'iz: SkerCbrhsophr -. '

Come out you democrats, you who advocate been offered for sale now awaits only the Lord Brougham the assault in.the. pursuance of tU vr'-iuc .r'paid.. Inte : ,
more on the first of President to become a. : ; :IN Notice i hrrrhr ivrn bat SXWIEXL.protection LaflW" far decks 'aad _ctuw trbwkT
Jacksonville, In Dovat County, known and described America. The Springs will be furnished and MMMed Del L ""'
place in. opened SAVANNAH GA. from the barsb ana ..and ,its easiness of access somrly' { wP .
oa the Map or plot of said .Town, as water by the. first day of)fa1. ,Charges will be moderate have secured It the mocb,improved. As f4r O..ftI Uf .
: I Lo .Q ber mae (9) and bounded on the North, and every attention* be paid to the comfort D&AU s in'the. following 'articles whkh will be from any of point il* : always'tdvaniajseous placfl fort, ,heOtberoute.5 q* ".,..

hyBtf street on the Sooth, by the River St. of all! who rosy favor,him riih their company. sold okas reasonable terms,


Ox Chains ShoveLs and Spade, Hay can be commanded in the town they may rrlj., or passengers barqtM line 'wliirb leaves passajHiJirig ''

:.. Store! &WbarC Taken In Execution,and will be JACKSONVILLE- and Manure Forks Patent and American S phes, upon the most careful attention.Northheienccasl41flll7 delayed Thursday'a J, S ton lay for New.sa"-,sA 2
old as the property the hue James B. Mason, S" JOVK. 10TH, 1846.JVO. Reap: Hoo1c Grain Cradles, Corn Shelters, Corn Avisitorsfmmthe under the. that the arrival of the St. Matthews from'Flortte.Passenger ,

on the first Monday of September was sold accorlin Militia of the County of Nassau, will be commanded Foolsrap,, Letter, Wrapping,"and, PRINTING ATTORNEYS AND COUN8ELLOBS AT LAW. WOOD & CLAGHORK.Arenli.. >

< to Law fay the .Administrator on the Estate_ ; by Lieutenant Colonel TIUCT: andand allowance ,R..G. LtrmosToir, Newnansvillr. July S. 1845.__ S

and C. and..B. M. Byrno., as will satisfy the cost the offices of Cnpa n.,First: and Second Lieutenants my acconnts and vouchers a. Administrator C. \V. DOWKIHG. 'do. S United States Hattl "'"

;. and charges for Advertising, and a balance of of said Companies giving at least ten days of the Estates James Martin, and Samuel i Th. "n) )'IIC t. SAXifl

U quality and situation of the Lands," made known at least,ten days notice to said inspectors of'their the same time apply to said Court for a final ATTORNEY AND COUNSELLOR AT LAW, nf hating been thoruojrUy a*>
un the day of sale. Said lands are situated in Ley appointment.III. discharge from the Administration of aid Estate Jacksonville FJa. hauled her


ilecks and raLin '.Lot1'1..cafe
!
Florida and will be sold the Court JOSEPH J. KNIGHT, Administrator. larged fur the accommodation of
/ County at As soon practicable after the S pa* eafei ,ha
iloose door (E. Daniels) of said County, by election for Officers of the several Companies of -Newnansviile, June 261846. Gm' 5-- C. GILLETT commenced hei regular I rip*.from' Palaiurultlerprue

and Tax Collector for LeyY'County. be officially reported at the Head Quarters of ALL persons .interested, are hereby notified ATTORNEY AND COUNSELLOB AT LAW. 125 miles above l'a1.a ka. ': '(

1 _July 10.Alacliua. the Regiment by the Commanders of Battalions. Six Months after date, I shall apply to Jacksonville, Fla221 The above'Boat, lro.ing PnUtk "T. '
: JOHN M. PONS, the Honorable the Court of Probate:for Alachuar Morning. after the arrival ofand sale thereof
in
attested for settlement. r
properly o'clock
date office of the"Florida Statesman"and is
Months after I shall apply to the now prepared
viz: an undivided share portion owned or claimed JOEL T1ESON, Adm'r. For fn-i-lil or .M ",apply in. the
pa Honorable the Court of Probate for th a county of toexpcute,with promptitudeall orders con- pa Captaia MHnanl.
by Frederick Marquand equal to 4554 actes _May 15th., 1846. GmAdministrator's Alaehua for a final settlement and allowance x>f Darted with the above line. or tu Frrnamlrz & Bivdrr, Arat Jack
thereof; in and to a certain tract of parcel of land end Mr. Grothe would also that I lie has determined .UI.Yil..
Notice. my accounts vouchers as administrator o.the say.
1aA known as the Arrcdondo, Alackua grant containing I I creditor,distributees and others interest Estate nfWHHam Dell),deceased,late


and SavaRBall SteaM
. Alacbua State of Florida. UM Hon. the Judge of Probate, of Nassau county, will ht>such a* to merit it. Packet.
4 county, ALSO at a Court of Probate, to be held at the CourtHouse HOLMES & CO.. From long practise in his hn.ine.f, h.* frr!. THE regular Strum Par''. W1.

l[ ,1 .
I
1 i. ? by John N. Sayer in the same said grant,equal January 1847, ,and chew cause if any they have MESSRS. of Merchandize the rharges will he/ minlcrrJe and as reasonable.'' l asthose ilve Ptrolals every Frtdajat a'. '
whyI should not be discharged from all further to large oldie North. in 9 A. M. on -orli week, and will Liure 114
thereof.
(t to 455 acres ALSO administration of the Estate of said Samuel Russell IFrench, given at the request of | areni tornfiheeuaf9AfAmItr.MnIIi.il. 'n' -- ----. .I .Jd..f"ft..d. .

Alnck1la. County Sheriff's Sale. of Georgia on motion of R.. G. Livingston, Esq., Circuit Court for the.Eastern Circuit of Florida -. S 0 S n'J .
}I. WILL E SOLD on Monday the 7th of Solicitor for the complainant, otherwise a',decree pro eonfttto will be granted Any pupil withdrawn frorn she School before the PURSUANT to an order of thVHo*

: mber n.xt. between the hour of ten It it Ordered That n hearing take place upon to the said complainant and that this Order he end of the session excepting for ""finshich the of tM! rJutrra C wA ifFIot4da

and two o'c ck,at the Court House in the Town tho facts charged in said Bill Complaint,


at the published in one of the puhlico new'p"rf re of the Principal approve will be required to pay for the in the above cause hearing date tk''

of Newaanh County Alacbua, a sufficient next term of the Circuit Court. for the, counties of Stnte for the, space of three months before, the unexpired part of that *c*,ion. ond day of March. 184G. the rredit"n IIlA.
portion of LII)ri undivided interest of John H. D"uh.CbrIi' Alachnaand Levy to be boldest on the third Moo- day .o appointed for the hearing of the cause. No dPdoetlonUI he madn in tbechirge against Hull. drrea&e4. lair of&*t Florida, (aIs4aunwthnbi 4

Brush Eugene Vannes, ,Julia A. day of December next, at the Court .House' in GEO. S HAWKINS Judge &c.I. a pupil for orcn/innal ablf"nnInUnited AID IT ruttTHia ORDIRKD. That a_copy p? Solicitor for the Complainant, 0 properly attested for settlement t
+ : : Jf 'rICE.J 1ns this Order, be published in some Newspaper printed It it Ordered, Tliat. the said Wjnslow Foster
: '1, States t on motion of complainants Solicitor, it is I JOHN ,
,j'L- > baring rlemands.against lh.. Es ordered 'that the wild defendants Ho'appear"and within.toe said Circuit eoee a .week consecutively and Maria fester do appear and answer the Con.pisinant's t'eb.2 1846. Sat .


Rumor: Next Battlefield is Bad Company 3, Says EA DICE Dev

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Rumor: Next Battlefield is Bad Company 3, Says EA DICE Dev

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Bad Company 3 is the game releasing this year as part of EA’s flagship shooter series, Battlefield. The news comes from a person who is believed to be an EA DICE developer and posted on Twitter, revealing the name of 2018’s Battlefield game.

Since the Tweet, his account has gone private. It is to be noted that he was not only followed by many of EA DICE developers but also the official Battlefield account. However, a current EA DICE developer doing something like this is highly unlikely.

When developing the game there is a strict NDA in place and breaking it could lead to serious consequences. It is absurdhis transcript prejudiced him.  However, because "pro se litigants are to be given reasonable opportunity to remedy the defects in their pleadings," Hall v. Bellmon, 935 F.2d 1106, 1110 n. 3 (10th Cir.1991), the district court erred in dismissing plaintiff's complaint with prejudice, without first giving him an opportunity to amend his complaint to cure any deficiencies.  See Forte, 935 F.2d at 2, 4 (holding that pro se prisoner plaintiff, who failed to indicate how alleged transcript alterations prejudiced him, should have been granted leave to amend his complaint against the court reporter so as to state claim);  see also McKinney, 925 F.2d at 365 ("Under Rule 12(b)(6), a plaintiff with an arguable claim is ordinarily accorded notice of a pending motion to dismiss for


citation of orders and judgments;  nevertheless, an order and judgment may be cited under the terms and conditions of 10th Cir.R. 36.3

1
 Moreover, plaintiff's right to a free transcript in order to file his habeas petition is not unconditional.  A petitioner seeking relief under 28 U.S.C. §§ 2254 or 2255 must first demonstrate that his claim is not frivolous and that the transcript is needed to decide the issue presented by the suit before the court is required to provide him with a free transcript.  See United States v. MacCollom, 426 U.S. 317, 96 S.Ct. 2086, 48 L.Ed.2d 666 (1976) (plurality) (interpreting a § 2255 petition and 28 U.S.C. § 753(f));  Ruark v. Gunter, 958 F.2d 318, 319 (10th Cir.1992) (applying the MacCollom analysischanges, the same can be said for the exercise component; if a person feels extremely sore and tired all of the time, their motivation to exercise will be very low, as they begin to only associate it with pain and a lack of energy.<br />Thankfully, there is a <i>proper </i>way (or a way that gives you a much better chance for long term success, at least) to make a lifestyle change in terms of fitness and nutrition. When it comes to nutrition, you can't go wrong with the "80/20" rule... Eat clean, healthy whole foods 80% of the week, and give yourself 20% wiggle room to indulge in things that may not be the best for you, but will satisfy your cravings. This way, you are less likely


Mistakes Beginners Make," not having clearly defined goals can be detrimental to your success. The biggest benefit of creating goals for yourself is that it gives you something to strive for, and ultimately, keep you motivated. When you first embark on your fitness journey, you have to ask yourself "what do I want to achieve?"
Setting clearly defined goals will in turn, allow you to have a plan of action to achieve them! If you do not have a goal (or several goals) before you enter the wonderful world of fitness, you are more likely to aimlessly plot along, just instinctively doing whatever comes to mind at the time. Now I will say, instinctive training has it's place, and I use it often; but I have been weight trainingis especially true when using dumbbells, because now each arm's stabilizer muscles have to work independently. For example, if you are doing a seated overhead dumbbell shoulder press, or a lying dumbbell chest press, each shoulder, pectoral muscle, and shoulder/elbow stabilizers have to do the work. This unilateral work will ensure that you minimize strength and size imbalances between each side of the body, top to bottom, and front to back.
The drawback to free weights is safety. If you are a beginner, or unsure of proper form and usage, you have a greater risk of injury with free weights, especially if you are not using a spotter.

Machines offer a variety of exercises for every body part. There are different types of machines, i.e. cable resistance,


1em;">

0Losing The Fathttp://electricfitness.blogspot.com/2015/06/losing-fat.htmlnoreply@blogger.com (Lee Dremel)Wed, 17 Jun 2015 13:14:06 PDTtag:blogger.com,1999:blog-6967658009695672303.post-5204290281066816079Stop focusing on getting "skinny," period. Instead, aim your focus on getting stronger and building lean muscle. This is the best way to burn fat. Add more lean muscle to your frame, and get that metabolism revved up!
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0Smart Liftinghttp://electricfitness.blogspot.com/2015/06/smart-lifting.htmlnoreply@blogger.com (Lee Dremel)Mon, 15 Jun 2015 09:40:10 PDTtag:blogger.com,1999:blog-6967658009695672303.post-326093602509818881One of my "50 Biggest Fitness Mistakes Beginners Make" topics, lifting smart vs. lifting with ego will allow you to make way better progress, and will allow you to be much less likely to suffer severe injury. Trust me, I'vebeen through it so I can give personal insight to the topic.
When bodybuilding for aesthetics (muscle growth and symmetry), it is far more important to train with a weight you can handle (and which allows you to keep proper form) then to try and throw heavy weight around for the sake of seeing how heavy you can lift. Keep an eye out for my future eBook, where I will go into further detail on this subject. Train hard and train smart!

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0Calories: Bulking and Cutting (Part II- Macronutrients)http://electricfitness.blogspot.com/2015/06/calories-bulking-and-cutting-part-ii.htmlnoreply@blogger.com (Lee Dremel)Thu, 11 Jun 2015 13:02:37 PDTtag:blogger.com,1999:blog-6967658009695672303.post-5911160966259957925In part I of this post, I talked about where to start in terms of a calorie range for bulking


of the Day: Ladies... Please squat! And lunge, and leg press, and split squat, and hip thrust, and... you get the point. Don't be treadmill Barbie!

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0Eat Salmon!http://electricfitness.blogspot.com/2015/06/eat-salmon.htmlnoreply@blogger.com (Lee Dremel)Mon, 01 Jun 2015 04:34:15 PDTtag:blogger.com,1999:blog-6967658009695672303.post-8344265734944002639Food of the Day: Salmon! Specifically, pacific wild caught (I prefer sockeye), because these cold water fish are proven to be healthier and more nutrient dense. Salmon is a great source of protein but just as important, an excellent source of healthy, monounsaturated fats and essential fatty acids DHA and EPA. Fun fact: the picture below is of spawning sockeye. An adult sockeye that is notmethods are not going to get you toned and burn fat optimally.

There are several reasons why endless cardio is not the answer. First off, cardio does not put your muscle under enough stress (breakdown) to elicit any sort of change when it comes to encouraging your body to get your muscles growing. Second, long duration cardio eventually puts your body in a catabolic (muscle burning) state, once your glycogen stores (the body's energy reserves) are depleted.
But the most important reason (in my opinion) why cardio is not the answer, is that it only elevates your metabolic rate for a short period after you finish. But fear not: there is something that will elevate your metabolic rate 24 hours a day, and that is lean muscle


a conductive sheet by punching or etching. After each semiconductor package is separately encapsulated with an encapsulation material, each of the lead frames is separated (singulated) from all other lead frames in the conductive sheet by a cutting or punching process.
When considering semiconductor packages such as Power Quad Flat No Leads (PQFN) packages and Power Dual Flat No Leads (PDFN) packages, the semiconductor dice have a metallic base and the dice are attached to their respective flags by a solder. The solder is pasted onto the flags and then the semiconductor dice are placed on the solder. The conductive sheet of lead frames is then placed onto a heating block in an oven. The oven heats the solder, causing it to melt, which bonds the semiconductor dice to// Generated by IcedCoffeeScript 1.3.3f
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to be lowered ever further to 1.28 gallons/flush. The 1.6 gallons/flush toilets currently described in the patent literature and available commercially lose the ability to consistently siphon when pushed to these lower levels of water consumption. Thus, manufacturers are being and will continue to be forced to reduce trapway diameters and sacrifice performance without development of improved technology and toilet designs.
Several inventions have been aimed at improving the performance of siphonic toilets through optimization of the direct jetted concept. For example, in U.S. Pat. No. 5,918,325, performance of a siphonic toilet is improved by improving the shape of the trapway. In U.S. Pat. No. 6,715,162, performance is improved by the use of a flush valve with a radiused inlet and asymmetrical flow of the water into the bowl.
U.S.


dividing the toilet tank into separate sections. See U.S. Pat. No. 1,939,118.
When flush volumes are pushed below about 6.0 liters, minimization of turbulence and flow restriction in the internal channels of a toilet is of paramount importance. One of the most significant factors in minimizing turbulence and restriction to flow is management of the air that occupies the rim and jet channels prior to initiation of the flush cycle. If the air is not able to escape the system ahead of the oncoming rush of flush water, it will continue to occupy space in the channels and restrict flow. U.S. Pat. No. 5,918,325 describes a toilet with jet channels that include an air discharging means, a passageway that connects the jet channel to the rim, allowing air toThe Twins are “closely monitoring” the market for catchers, including the likes of A.J. Pierzynski, Derek Norris, Jonathan Lucroy and Alex Avila, reports Mike Berardino of the St. Paul Pioneer Press.

It’s not certain at this time how available each of those names might be, but Berardino writes that the Braves are open to trading Pierzynski, which comes as no surprise when considering that he’s a 38-year-old veteran playing on a one-year deal for a club that is seven games back in its division. One can imagine that the Tigers, who as of last night are reportedly planning to be sellers at the trade deadline, would be open to moving free-agent-to-be Avila.

Pierzynski has a $2MM base salary in 2015, of which roughly $841K remains. His contract also contains incentives


in Brooklyn earlier today, the mayor indicated he was prepared to pull back the hit list if the state Senate finally acted.

“I thought they’d solve their problems two, three weeks ago,” said the mayor. “I don’t think anybody expected this to go on, yet it does. Does that mean it’s going to go on forever? Common sense says they have to at some point come up with a resolution.”Various fabric accessories are utilized throughout a home to provide a particular room decor. Such accessories include drapes and valances for windows, printed paper for walls and/or ceilings, wood trim and chair rails, throw pillows, and various other items. Often, the home owner will attempt to coordinate various room accessories and furniture, such that the curtain and valance fabric matches or complements the fabric on furniture within the room.
The addition of a ceiling fan to a room can detract from the room decor, because the fan blades have either a woodgrain pattern or a painted surface, which do not complement or match the fabrics of furniture within the room.
Although ceiling fans are now available in a variety of styles, the fan blades are not formed of fabric which


engage the North in order to revive the denuclearization process and repair inter-Korean relations.

Three widespread misconceptions distorted the coverage of Kim's visit to China. The first misconception is that he desperately sought Chinese aid to prop up his regime in the face of seething discontent after botched currency reforms. But, although North Korea’s latest economic travails have shaken the leadership, the regime has weathered worse. And the economic relationship between China and North Korea is driven as much by material interests and economic factors as it is by concerns over geopolitical stability.

Indeed, trade overshadows aid, and China—led by its border provinces—is now North Korea's main trading partner and source of foreign investment. Chinese Premier Wen Jiabao announced a major trade package during his trip to Pyongyang last November,However, fewer particles were isolated from cells expressing PAP (21% relative to −PAP), which was also evident when the same volume of isolated virus was probed by northern blot and less viral RNAs were seen associated with particles from PAP-expressing cells (25% relative to −PAP, compare +PAP with RNase A to −PAP with RNase A; [Figure 1](#F1){ref-type="fig"}B). To ensure that RNA not within particles was excluded from the virion preparation, resuspended particles following centrifugation were treated with RNase A prior to northern blot analysis. The intensities of bands in [Figure 1](#F1){ref-type="fig"}B showed no significant difference between nuclease-treated and -untreated particles, indicating a lack of free unencapsidated RNAs. As a control for RNase A activity, BMV RNAs isolated from virions were also treated with the nuclease and show complete


RNAs were isolated from *in vitro* assembled particles and gel purified RNA3 (0.5 µg) was used for reverse transcription and radioactive PCR. The control lane represents *in vitro* PAP-treated RNA3 used for RT--PCR. Values are means of intensities for RNA3 ± SE for three separate experiments. (**C**) Northern blot analysis of RNA3 treated with PAP (+PAP) or buffer alone (−PAP), before its assembly (0 h) and isolated from *in vitro* particles 24 h following assembly. *In vitro* transcript of RNA3 was loaded into one lane to serve as a size marker (std).

Depurination inhibits binding of CP to RNA3
-------------------------------------------

To test whether CP distinguishes depurinated from intact RNA3, PAP-treated or untreated RNA3 was incubated with isolated CP and interaction was assessed by filter binding. The affinity of CP for PAP-treated RNA3 was ∼6-fold less comparedin binding affinity were not due to degradation of BMV RNA3 upon PAP treatment ([Figure 5](#F5){ref-type="fig"}C). Figure 5.Depurination inhibits binding of CP to RNA3. (**A**) Binding curves of CP with PAP-treated and untreated radiolabeled wild-type BMV RNA3 and (**B**) PAP-resistant RNA3 (R-RNA3). Transcripts were incubated with increasing concentrations of BMV CP before passing through a nitrocellulose membrane. The amount of retained RNA3 was quantified by scintillation counting and corrected by subtracting background counts in the absence of CP. Points are means ± SE for three separate experiments. The *K*~d~ values were obtained after results were fitted to the one site binding equation using Graphpad Prism 4. (**C**) Radiolabeled wild-type RNA3 (RNA3) and RNA3 resistant to depurination (R-RNA3) were treated with PAP (+PAP) or buffer alone (−PAP). The RNAs were separated


of depurination at A771 and A1006 on the quality of RNA3 packaged *in vivo*. *In vitro* transcripts of RNA1, 2 and either wild-type or mutant RNA3 were transfected into barley protoplasts along with a plasmid encoding the PAP gene (+PAP) or empty plasmid (−PAP) and allowed to replicate for 18 h before viral particles were isolated. (**A**) RNAs were isolated from viral particles and equal amounts of gel purified RNA3 (0.5 µg) were used for reverse transcription and radioactive PCR. Values are means of intensities for RNA3 ± SE for three separate experiments. (**B**) Total RNA was isolated from protoplasts, RNA3 was gel purified and reverse transcribed in the presence of \[α^33^P\]-dATP. The intensities of truncated bands, due to depurination, were plotted relative to total RNA3. Bars represent mean percent depurination ± SE forand his campaign accounted in its campaign records for the cash contributions for Mr. Smith,” Dowless states in the affidavit.

While Smith was sidelined by the damage to his business, Dowless was just expanding his operation. In the 2016 election cycle, Dowless worked for Todd Johnson, an insurance salesman from Union County, who was running in the House Republican primary against Harris and Robert Pittenger. According to the Washington Post, Johnson received two hundred and eleven mail-in votes, compared to just four for Harris and one for Pittenger, who ultimately won the race. But, during the 2016 election, Dowless was not just helping other candidates—he was also running as the incumbent vice-chairman of the Soil and Water Conservation District board, a nonpartisan elected position.

According to Patsy Sheppard, a local


melanoma cell lines and NHEMs.

![The expression of FOXM1 mRNA and protein in malignant melanoma cell lines, NHEM cells and PANC1 cells.\
PANC1 cells were used as a positive control. (a) The results of the quantitative RT-PCR analyses of FOXM1 mRNA expression. The relative transcript levels of FOXM1 normalized to the level in PANC1 are shown. (b) The expression of FOXM1 proteins in the malignant melanoma cell lines and NHEM. (c) The results of the quantitative RT-PCR analyses of the miR-370 mRNA expression. (d) The results of the semiquantitative RT-PCR using primers that can detect three splicing variants: FOXM1a (472bp), FOXM1b (323bp) and FOXM1c (368bp).](pone.0144241.g001){#pone.0144241.g001}

We also performed a Western blot analysis of the melanoma cell lines and NHEMs, and found that the expression levels of FOXM varied from one cellthe primary malignant melanomas and 67% of the metastatic melanomas evaluated in this study expressed FOXM1, it would be inappropriate for all patients with melanoma to be treated with FOXM1-targeted immunotherapy. In fact, we demonstrated that immunotherapy employing multiple tumor-associated antigens is more effective than that employing single tumor-associated antigens \[[@pone.0144241.ref031]\]. Furthermore, multiple peptides cocktail vaccine (KOC1, FOXM1 and KIF20A) has already been tested for the patients with refractory pediatric sarcoma in phase I study. In future clinical trials, the use of multiple antigen-targeted immunotherapies, including FOXM1, should be also considered in melanoma. We believe that the combination of immunocheckpoint blockades and antigen specific immunotherapy, utilizing FOXM1, will therefore make immunocheckpoint blockades more effective. Moreover, it has been shown that higher expression of FOXM1 is associated with a


AKT phosphorylation \[[@pone.0144241.ref020]\]. FOXM1 has been shown to have cross-talk with the MAPK pathway in malignant melanoma \[[@pone.0144241.ref017], [@pone.0144241.ref018]\]. Cross-talk between the AKT pathway and the FOXM1 pathway has been demonstrated in osteosarcoma and prostate cancer \[[@pone.0144241.ref021], [@pone.0144241.ref022]\]. We conducted an MEK siRNA analysis in four melanoma cell lines, and found that MEK1 siRNA downregulated the expression of FOXM1, together with p-MEK, in two melanoma cells. ([Fig 6](#pone.0144241.g006){ref-type="fig"}) We showed that the inactivation of AKT by PI3K and AKT inhibitors decreased the expression levels of FOXM1 in melanoma cell lines. Furthermore, we found that the downregulation of FOXM1 by FOXM1-specific siRNA inhibited the proliferation of melanoma cells *in vitro*. In patient samples, we found that 55.2% of the cases that were positive for FOXM1 were also positive for16 Actors That Can’t Stand Their Iconic Roles

“Actors do tend to be very self-critical. I have a hard time watching any of my performances,” Kate Winslet said in one of her interviews. This is also true for her role in the iconic film, Titanic.

We at Bright Side did some research and found that Kate Winslet isn’t the only actor who thinks this way. In fact, many actors and actresses don’t like their roles. And very often, they hate the roles that earn them awards, critical acclaim, and tons of money.

1. Kate Winslet, Titanic

The role of Rose made the actress word-famous and won her an Oscar nomination and the film itself got 11 Academy Awards. Many critics said that Winslet acted perfectly even though she disagrees with them. “Looking