at Hamilton. Phillipps majored in philosophy and earned a master’s degree in filmmaking from the California Institute of the Arts. They both did photography as Hamilton students.

Adam Bedient ’04 on assignment.

Phillipps heads Off Ramp Films, a video production company, and is a field producer and editor at Hock Films. Although years apart on College Hill, he and Bedient have been working together for nearly a decade. Bedient discovered Phillipps through a Hamilton connection, and he contacted the filmmaker, asking if they could meet. When they did, Phillipps happened to need some help on a project. Bedient stepped up, and the partnership stuck.

Typically Bedient shoots and Phillipps directs. “But we’re pretty fluid on that since it’s a small team, and we’re collaborative as far as the whole process. WeQ:

mongodb use 'copyDatabase', but don't copy collections

I use 'copyDatabase' to copy local db to remote db.
cosole just return
{
    "ok" : 1.0
}

db was created but dont' have any collecitons in it.
collections was not copied.
I try same command on local, copy db just on local.
It works.
Remote is Ubuntu on aws
Remote mongo version is 2.4.9

A:

I am on Mongo 3.4 but you can try:
db.cloneCollection(from, collection, query)
or:
db.cloneDatabase("hostname")
Docs are here.
EDIT:
Based upon the OP's comment
use MongoDump and MongoRestore in v2.4
This will dump the db and collections and then restore where you want
Docs are here for that in 2.4


Introduction {#Sec1}
============

Bemfola^®^ is a biological medicinal product similar to the licensed Gonal-f^®^ (recombinant human follicle-stimulating hormone r-hFSH, INN Follitropin alfa). Follicle-stimulating hormone (FSH) is a pituitary glycoprotein hormone that plays a key role in regulating reproductive function in both males and females.

FSH is a heterodimeric hormone composed of two linked subunits. The alpha-subunit (92 amino acids) is common to other glycoprotein hormones and the beta-subunit (111 amino acids) is specific.

For clinical use either FSH extracted from the urine of postmenopausal women (u-hFSH) or recombinant human FSH (r-hFSH) is used.

For the production of Bemfola^®^, a Chinese hamster ovary cell line transfected with the genes coding for the alpha and beta subunits of human FSH is used.

Gonal-f^®^, which has been commercially available since 1995, is an example of a currentlysecondary PK parameters (i.e., *C*~max~, *t*~1/2~, *T*~max~, *K*~e~) was observed between Bemfola^®^ and Gonal-f^®^ (Table [1](#Tab1){ref-type="table"}). Mean *C*~max~ for Bemfola^®^ was observed at 5.69 IU/L and for Gonal-f^®^ at 6.01 IU/L, with a confidence interval of 0.89 to 1.01. In particular, the median T~max~ was identical after FSH application for Bemfola^®^ and Gonal-f^®^ \[Bemfola^®^: 24.0 h (range 6.0--24.0); Gonal-f^®^: 24.0 h (range 9.0--24.0)\]. In addition, mean *t*~1/2~ values were comparable between Bemfola^®^ and Gonal-f^®^ \[43.58 h (standard deviation 14.17) vs. 42.58 h (standard deviation 16.47), respectively\]. Similarity was observed for the elimination rate constant *K*~e~, with 0.0075 1/h calculated for Bemfola^®^ and 0.0077 1/h for Gonal-f^®^. Lastly, no period effect was seen for *C*~max~ (*p* = 0.876).

Comparison of E2 concentration between Bemfola^®^ and Gonal-f^®^ {#Sec12}
----------------------------------------------------------------

The original study protocol was amended to add an additional secondary study objective, to assess


is partially substituted into LiNiO2 or LiMnO2.
According to European Patent No. 0918041 or U.S. Pat. No. 6,040,090, LiNi1-xCoxMnyO2 (0<y≦0.3) has improved thermal stability compared to that of materials composed of only Ni and Co. However, LiNi1-xCoxMnyO2 (0<y≦0.3) may not be commercially developed due to its reactivity with an electrolytic solution of Ni4+. In addition, European Patent No. 0872450 discloses LiaCobMncMdNi1-(b+c+d)O2 (M=B, Al, Si, Fe, Cr, Cu, Zn, W, Ti, or Ga) in which Ni is substituted with another metal as well as Co and Mn. However, the thermal stability of the Ni-based material is not yet solved.
To solve this problem, Korean Patent Laid-open Publication No. 2006-00355547 discloses a double-layered cathode active material including an internal part composed of a nickel-based internal active material and an external part composedEffect of Furan Fatty Acids and 3-Methyl-2,4-nonanedione on Light-Induced Off-Odor in Soybean Oil.
Soybean oil is one of the most widely consumed vegetable oils. However, under photooxidative conditions, this oil develops a beany and green off-odor through a mechanism that has not yet been elucidated. Upon photooxidation, 3-methyl-2,4-nonanedione (3-MND) produces a strong aroma. In this study, the effect of furan fatty acids and 3-MND on odor reversion in soybean oil was investigated. Our findings suggest that the observed light-induced off-odor was likely attributable to the furan fatty acids present in the oil through the generation of 3-MND. While 3-MND may not be directly responsible for the development of light-induced off-odor, this compound appears to be involved because off-odor was detected in canola oil samples containing added 3-MND. In addition,


on your device Media caption Students say Michelle Obama has charm and Hillary Clinton needs her

A People magazine reporter also said she was forcibly kissed, while another woman said Mr Trump grabbed her bottom.

Making his first public appearance since the allegations were made, Mr Trump told a rally in West Palm Beach these stories were "a conspiracy against the American people" by the political and media establishment.

He said he had evidence the accusations were unfounded and would release that at the "appropriate time".

In one reference, he appeared to imply People writer Natasha Stoynoff could not have been telling the truth because of her appearance.

"Take a look. You take a look. Look at her, look at her words, you tell me what you think. I don't think so, Iapplicants — and not just those he or she might suspect of being in the country illegally — in order to avoid violating anti-discrimination laws. On top of that, it’s no easy matter to accurately determine someone’s immigration status.

Enter the Maine Municipal Association.

There’s a legitimate legal battle at stake here, and the Maine Municipal Association is attempting to resolve the legal quandary. We applaud the association for intervening.

Both the LePage administration and Attorney General Janet Mills have valid legal points to make in this controversy.

LePage says he has authority to cut off aid to undocumented immigrants due to a provision of the 1996 federal welfare reform law that prohibits states from giving out benefits — even benefits such as General Assistance not funded at all by the federal


government — to “qualified aliens.” However, if a state passes a law that “affirmatively provides for such eligibility,” the prohibition doesn’t apply. Maine has no such law on the books.

Mills argues the administration, in order to carry out the policy change, at least needs to abide by the Maine Administrative Procedure Act that outlines a process for executive branch agencies to follow when they develop new rules to carry out existing laws and administer state programs. That process provides for public input and a legal review by the attorney general’s office.

The Maine Municipal Association on Thursday petitioned the Cumberland County Superior Court in order to force a judge’s ruling on the legality of the LePage administration’s General Assistance directive. The group, which represents the state’s towns and citiesalso summarized descriptively.

Clinical factors which could affect the HbA1c reduction between responder and non-responder groups were analyzed using chi-square test in 3 different strata. We performed multivariate logistic regression test to adjust the potential variables for the HbA1c reduction in each stratum. To confirm the correlation between changes of HbA1c and body weight, scattered graph was rendered and correlation coefficient was calculated. If *p*-value is less than 0.05, it was considered statistically significant.

Results {#Sec8}
=======

Baseline clinical and laboratory characteristics of participants {#Sec9}
----------------------------------------------------------------

Of the total 1269 patients who received more than one-time injection of exenatide twice a day, data retrieved from 754 patients who completed 20 weeks treatment with exenatide were analyzed for the safety profiles (safety analysis set). Among the 754 participants, 619 patients who measured HbA1c level both at


overcoming drug delivery system, long-acting GLP-1 s are now gaining popularity as innovative drug in managing the subjects with T2DM. Because of plentiful accumulated reports on exenatide, the first-in-class drug of GLP-1 analogue, the debate on clinical relevance of exenatide might be little. However, the clinical relevance on effectiveness and safety are reported mainly under the designed trials with the statistical expectations. We hypothesized that reluctance might remain to generalize the results of RCTs retrieved from a specific segment of the population to broader population or real practice \[[@CR16], [@CR18]\], and that it might be more important to both patients and physicians in managing the diabetes after identifying the results of RCTs with those of observation studies (OSs) retrieved from routine care. Based on these hypotheses, we aimed thisthe GOP is eager to face in the fall?

The answer is, maybe.

Ralston noted yesterday that “ organized ” Republican efforts to intervene in the Democratic contest are now underway. This includes College Republicans urging members to support the “socialist” in order to help the GOP candidate “prevail” in November, and coincided with work from a prominent conservative activist in Nevada encouraging Republicans to intervene with a similar message.

Time will tell whether this activism has its intended effect, and if Clinton hangs on, it’ll be a moot point. What’s more, if Sanders wins in a landslide, there won’t be much room for quibbling.

I can’t help but wonder, though, if Nevada Republicans fully appreciate the potential for unintended consequences. What they want is a Sanders victory. What they don’t want


NASA/JPL

Cracks in an instrument designed to detect earthquakes on Mars will add roughly US$150 million to the price tag of InSight, NASA’s next mission to the red planet. But the agency said on 9 March that it still intends to fly the spacecraft, raising questions about how the unexpected expense will affect other planetary missions in development.

And although InSight’s launch — originally scheduled for this month — is now slated for May 2018, it is not clear whether the spacecraft's faulty seismometer will be ready in time. InSight seeks to investigate Mars’s interior by measuring seismic activity, the heat that is escaping from the planet and the movement of its surface.

“We’re really grateful that NASA has recognized the value of science we’re going to do and agreed toThey claimed to see into the future. This insinuates that the figure is a "vehicle" for moving consciousness through imaginal time and space. It seems to be a metaphysical "time machine," or inter-dimensional gateway.

As in most design or mandala meditations, the aspirant pictures him or herself at the center of the figure through visualization, contemplation, and identification. Through this process of centering, these mystics came to know themselves and God. Perhaps they learned, as Fuller later discovered, of the unusual anomalous conditions of perfect equilibrium. This meditation provided a specific technique for escaping from time. Its realization meant instantaneous enlightenment, a paradoxical leap out of Time. It yields transcendence.

Occultist, Paul Foster Case published an array of this type in his book, The Tarot (1947). Aware of the ancient


it includes everything from the beauty of Platonic solids and the Golden Mean spiral and Fibonacci sequences to Pythagorean and Vedic mathematics, alphanumerics, kabbalistic glyphs, Merkabah Mysticism, Bucky Fuller's tetrahedral Synergetics, to artistic subject matter, such as Fractals, Cymatics, Yantras, Mandalas, and magic squares and circles. Even crop circles showcase sacred geometry, regardless of their origin.

To me geometry is "sacred" when it reflects Nature, and our own nature, as experienced externally and internally. There is evidence that geometry and hieroglyphics developed through cymatics, the acoustic resonance between sound and form. Simple sand on a drumhead will produce many classical geometric forms and embryonic letters or numbers. Our DNA forms our bodies in the same way with sound and coherent light (see my Bioholography paper). It is the songremoval is widely recognized in a number of other fields. For example, in many oil-lubricated machines, such as internal combustion engines, in which the lubricating oil is recirculated, a portion thereof is circulated through a bypass filter, thus extending the effective life of the lubricant and of the engine or machine itself. Similarly, in the clothes washing art, an auxiliary water recirculating path is often provided to pass some of the water through a lint filter for subsequent separate removal.
Thus, the more soil removed from the primary recirculating and spray system within the warewasher, and the faster it is removed, the fewer wash and/or rinse cycles--and hence the less hot water--required. Further, by prolonging the usefulness of the water, early soil separation and removal can reduce the amount


A radio show and podcast weaving stories and science into sound and music-rich documentaries.
Radiolab is supported, in part, by the National Science Foundation and the Alfred P. Sloan Foundation, enhancing public understanding of science and technology in the modern world. More information about Sloan at www.sloan.org.

B.C. university bosses paid $1.1M in excess, NDP says

Who’s keeping an eye on how much B.C.’s post-secondary bosses are raking in?

According to an NDP investigation, Capilano College, University of the Fraser Valley and Vancouver Island University paid 14 executives a total of $1.1 million dollars over the government-set salary cap, over three years.

MLA David Eby says now the minister responsible won’t talk.

“We’re calling on the ministry of advanced education to release the caps. What are the rules across B.C.? And then everybody canam the moron who wonders why he is carrying the bricks." - suicide note,

as quoted in Existential Psychotherapy by Irvin D. Yalom

Unfortunately, a lot of folks these days encourage us to just keep carrying bricks.

There seems to be an entire cottage industry around it. (Especially, ironically enough, somehow, a lot of philosophy professors.)

"Just carry your bricks," they seem to say.

Their message is, essentially, “Don’t think about it, just put your head down, distract yourself, find something else to do, move on, and hopefully your questions will go away.”

If we were living in a movie, they might be saying things like "Don't ask about 'The Matrix!'" Or "Just be content inside your 'Truman Show.'" Or "Have a nice day! It's Groundhog Day!")

So let’s be clear on this:

Asking these questions


certain measure of intelligence - see life in a certain way that it appears meaningless. After all, we live for several years, then die. We work and work, but eventually everything we are working on crumbles to dust. What, then, is the point?

"She's polishing the brass on the Titanic, man.

It's all going down."

- "Tyler Durden,"

from the Chuck Palaniuk novel/David Fincher movie Fight Club

Why, since living means suffering to one degree or another - sometimes suffering immensely - how and why do we push through it? How and why can we move through and beyond the slings and arrows?

Or in a sense, this is another way of asking "Why Are We Here?"

"The truth is that your daily life is but a thin strip of experience

barely seeming in the profunditybecause any "thing" is, given a long enough time span, necessarily impermanent - then suffering, when that change comes, is inevitable.

This is why many spiritual teachers speak of an attitude of "detachment" - which is not coldly keeping oneself removed and distant from life, but maintaining a proper perspective in things, and not making them the ground and nature of one's own purpose of life. In a way, ignoring impermanence is like looking for "IT" in all the wrong places, or searching for something permanent in the impermanent, for God in places or things where God will not be found.

"It is not for man to seek, or even to believe in, God.

He only has to refuse his ultimate love to everything that is not God.

This refusal does not


meditator seeks to be pure participant.

In both there is the search for the One at the expense of two...

Both extremes, observing and participating, simply "get rid of" ego by a trick.

Both, if used as a form of meditation, lead students

to resent the "interference" of life with their "practice":

on the one hand, seeing life more and more

as a meaningless parade,

scorning people who participate and get involved;

and on the other hand, feeling more and more put upon by things,

feeling increasing self-pity and seeking quiet

- or paradoxically, seeking intense orgiastic situations

such as acid rock, strobe lights, drugs, or the rallies of demagogues and faith healers."

- from The Iron Cow of Zen by Albert Low

Low does not propose a simple "solution" that can be accurately expressed in words, but essentially recommends a"Objective Meaning":

This option entails the idea of meaning that is "objective" - that isn't personal.

This can get complex, but essentially, it can entail experiences that can relieve feelings of meaninglessness.

These experiences, in other words, can provide meaning. They can infuse meaning into something that otherwise seems meaningless.

Of course, the entire idea of "objective" meaning can be controversial, because some folks assume that everything is meaningless, full stop, end of discussion.

But of course, that's an assumption.

Just because a particular person hasn't seen a black swan doesn't mean that no black swans exist anywhere. (They do exist.)

Similarly, just because a particular person hasn't discovered a form of objective meaning doesn't mean that no objective meaning exists anywhere.

Take a common light bulb.

It sits on a store shelf for several weeks, doing


the red-headed mountain nymph only to disappear for ever – and it’s from this little devil that the mountain supposedly made itself a name!

Information

Altitude: 2973m
Accessibility:
Train from Chur or St. Moritz to Berninan Diavolezza (partly with change of transport, or bus from Pontresina), cableway to the Diavolezza
View:
Over the Pers and Morteratsch glacier world; behind the Piz Palü massif and Piz Bernina and looking north the Val Bernina together with Bernina Pass
Attractions:
Diavolezza – Morteratsch glacial hikes, two via ferrata ascents with varying levels of difficulty, evening mood on the summit and overnight stays in the mountain guesthouse
Culinary aspects:
Regional cuisine with tasty Graubünden and Veltliner recipes
Overnight stays:
Berghaus Diavolezza: Double and multi-bed rooms
Groups:
Restaurant Bellavista 120 places, Diavolezza Stübli 50, self- service 100 places; also suitable for workshops and meetings Winter:
Winter sports regionAbout me, my sister and baby brother....

I'm a 10 year old red heeler,my barkday is April 2nd. I was rescued, by my wonderful mom, from the south central shelter in Los Angeles the day I was supposed to be put to sleep. I had been in isolation for a month with kennel cough, which meant no one came to see me....but my mom did and she saved me! She called me her bat-eared girl when she first got me and took me home that day...but I have turned into her beautiful red heeler and I love my mom!

And now I have a little sister who mom named Ceilidh (K-Lee). She is about 3 years old, so that puts her barkday around September 5th. She was rescued from the


together, please." "Round end..." "What is this?" "Randomly-tossing-your-paddle day?" "Ned, you bought our house." " Why?" " So I can rent it back to you." "Just pay what you can till you get back on your feet." "Ned Flanders, I can't believe what you doodily-did for us." "Well, as the ocean said to the dirt, I appreciate the sediment." "And on the zillionth day, God created hugs!" "And it was good!" "Come on, kids." "Let's take our stuff back inside." "(HOMER STUTTERING)" "Better let me go first." "I left a little surprise upstairs for the new owner." "(EX CLAIMING ANXIOUSLY)" "(SINGING) For he's a fabulous Flanders" "Which nobody can deny" "He saved our ass" "Okay, everyone, squeeze in!" "(CAMERA CLICKS)" "BART:" "Evil triumphs again." "(BART LAUGHS)" "Ow!" "(LAUGHS)"say, don't evict the Simpsons!" "Say, Jesus, what was the name of the son of Zachariah?" "It was..." "Do you have a computer nearby?" "He's nailing something to our door." "I wonder if it's theses." "That's gross." "Homie, I think it's an eviction notice." "We're gonna be homeless like Lucille Ball in the Stone Pillow!" "Don't worry, Marge." "According to this chapter book, we have a secret weapon." ""Evictee will be granted a stay of eviction" ""if said household includes a resident aged 65 or over."" "Finally, a practical use for my father." "Whee!" "I'm gonna live like a human in a real house." " What's the catch?" " I'm using you." " For what?" " My own devices." "All right." "Tell the world what you saw here."


"I'm gonna miss putting makeup on him while he sleeps." "ATTENDANT:" "I've already moved on." "(GROANS)" "Hey, Flanders." "You can't evict us because a senior's living here now!" "(LAUGHING)" "You're never too old to ruin things for the young." "(HUMMING HAPPILY)" "Will you kids knock it off!" "I'm trying to watch badminton!" "Dad, we've been trapped in the house for days." "Can't we play outside?" "Yeah." "Without the sun, my hair is reverting to its natural red." "I don't want to be called Rusty again." "I don't!" "You know, it says here that Grampa has to remain in the house, but we don't." "How about a family outing?" "Family outing?" "I'll start." "Lisa's gay!" "Right. 'Cause I wouldn't want to be gay like my heroes," "Billie Jean King,become lattice defects and work as a trap level trapping carriers, causing a great decrease in electron-mobility of TFTs.
In order to solve the above-mentioned problems of the crystal particle boundaries in method (3), the following two methods (4) and (5) have been proposed.
According to method (4), impurities such as silicon (Si.sup.+) are introduced by an ion implantation method or the like, and then a polycrystalline silicon film having a crystal particle size of several .mu.m is obtained by heat treatment (Japanese Laid-Open Patent Publication No. 5-55142).
According to method (5), silicon particles having a particle size of 10 to 100 nm are sprayed onto an amorphous silicon film together with high-pressure nitrogen gas to form growth cores (Japanese Laid-Open Patent Publication No. 5-136048).
In both of methods (4) and (5),


  In an effort to avoid the bar of     Stone v. Powell , Washington argues that his

case presents a more general due process violation because the Oklahoma state

courts arbitrarily failed to follow Oklahoma law relative to nighttime searches.        1

He characterizes his position as one challenging the fairness, integrity, and

legitimacy of the judicial process,       citing Rose v. Mitchell , 443 U.S. 545, 562

1
       Given the specific nature of the handwritten language on the search warrant
in this case, and its closeness to the statutory language, petitioner’s case is
distinguishable from those Oklahoma cases cited in his brief. The almost-perfect
compliance with the statutory dictate here also distinguishes hishis trial, the majority decision suggested repeatedly that the cure to the problem could come from Congress.

"No emergency prevents consultation with Congress; judicial insistence upon that consultation does not weaken our nation's ability to deal with danger," Justice Stephen G. Breyer wrote in a concurring opinion. "The Constitution places its faith in those democratic means. Our court today simply does the same."

In its ruling, the court did not summarily reject the use of wartime tribunals, which have been used across U.S. history - although not since the World War II-era trials of eight German agents sent to the United States with a failed mission to destroy war factories, canals, bridges and train stations.

And Stevens pointedly noted that the court was not challenging the government's authority to hold Hamdan


the Justice Department under President Ronald Reagan, said the ruling demonstrated that "the court has simply failed to grasp that we are at war."

But administration critics said the outcome was an important check of presidential powers. Michael Ratner, president of the Center for Constitutional Rights, which represents many of the Guantanamo detainees, said that by invoking protections under a key provision of the Geneva Conventions - Common Article 3 - the decision would have broad ramifications for the U.S. treatment of terrorist suspects.

"What this says to the administration is you can no longer decide, arbitrarily, what you want to do with people - you have to abide the dictates of the Geneva Conventions' Common Article 3," Ratner told reporters.

The court's holding that the provision should apply drew considerabledefense of necessity, a defendant must show (1) that they committed the charged offense to prevent a significant evil, (2) that there was no adequate, reasonably available alternative to committing the offense, and (3) that the harm caused by the charged offense was not disproportionate to the harm the defendant avoided by breaking the law.[1] Moreover, if the offense is a continuing one (such as a driving offense), the defendant must show (4) that they stopped violating the law as soon as the necessity ended.[2]
Of the elements listed in the preceding paragraph, elements (1), (2), and (4) are judged from the perspective of a reasonable person in the defendant's position. Thus, the question is what the defendant reasonably believed at the time, even if it later turns out


CSF of 6% children and adults with focal encephalitis with unknown origin ([@R6]).

In this study HHV-6 DNA was detected from 6% of CSF specimens obtained from 100 children younger than 2 years old who were referred to Pediatric Medical Center. The results were similar to several investigations in various areas worldwide. For instance, Ward and coworkers studied 200 children younger than 2 years old with primary HHV-6 infection. They detected HHV-6 DNA from CSF in 7% of cases ([@R6]). Of course, in some studies the prevalence of HHV-6 has been lower or higher than this study. For example , in Tavakoli & Hull study in 2007, prevalence of HHV-6 DNA positivity in 1482 CSF samples obtained from cases with meningitis or encephalitis was reported to be 1.75% ([@R7]).SELECT ST_GeogFromText('POINT(37.611100 55.756926)') AS geo_data
)
SELECT
  ST_AsText(location.geo_data),
  ST_Distance(pt.geo_data, location.geo_data) AS distance
FROM location
JOIN pt
ON ST_Dwithin(pt.geo_data, location.geo_data, 1200)
ORDER BY distance
LIMIT 1


wasn't happy about a game ending in that fashion, especially against a tough pitcher such as Angels closer Cody Allen.

"I don't know," Schwarber said when asked about his manager's idea. "I don't know how you can do that. I just didn't like the way it ended, [after] grinding out an at-bat against him. It was a big situation right there. I worked him. You've got to battle. I thought I didn't go, and he thought I did."

The final pitch resulted in Schwarber's second checked swing during the at-bat against Allen. The first one was called a ball, though it appeared that Schwarber might have gone further on the first check swing than the one that ended the game.

"If I didn't go the first time, I didn't go thehave walked 5.05 batters per nine innings this season, the most in the major leagues.

"Really tough," Maddon said. "Love the fight. I thought we came back, had to fight through, but we just walked too many guys from the pitching perspective."

Nevertheless, it could have worked out for Chicago in the end, if only Schwarber had gotten one last swing.

"I was a little hot," Schwarber said. "I'm able to calm down now, but I wasn't the happiest person in the world."


Update: The alphabet is now available as a beautifully printed book. Since it contains the letters already precut, it saves a lot of time.

A papercraft alphabet – 26 fine templates to print out, fold and glue into letters. Each one represents a thing (or animal, or people) starting with that letter.

This alphabet can be a nice and playful learning resource for kids – the younger ones will need some help in assembling the models.

In addition to being nice little toys (my son has instantly fallen in love with the letter A – or astronaut), you can write all kinds of nice messages with them, such as ‘I love you’ or ‘Please pay the rent ASAP’…

Works in English as well as in German (and, at least to some extend,midwives, and the paramedics to the GPs - by helping to create a map of gratitude from every corner of Britain.

We need our health workers now more than ever as they work superhuman hours and go above and beyond to protect us.

Click HERE to drop a heart or a message on the map, and show you appreciate the efforts undertaken daily in the NHS.

You can now also make a donation to NHS Heroes Help From Home, starting from £2.. As a thank you, everyone who donates will be entered into the weekly NHS Heroes Raffle.

Click HERE to donate or to find out more - or click the link from within the Thanks a Million map.

Thanks a million, NHS workers - we love you.

Locally, more needs to be done


is a charity providing advice and support to empower anyone experiencing a mental health problem. They campaign to improve services, raise awareness and promote understanding.

Read More

Related Articles

Last night, Professor Neil Greenberg, a member of the Royal College of Psychiatrists and the Health Protection Research Unit at King's College London, said the frightening experience of Covid-19 may still leave a lasting impression.

He said it was better to speak to people you trust about how distressing the experience was, rather than to avoid the subject.the redshift[@ioka03; @inoue04] according to the following expression: $$\label{eq:DM-z-baryons}
  \mathrm{DM}_{\mathrm{IGM}} = \frac{3 c H_0 \Omega_{\mathrm{IGM}}}{8\pi G m_{\mathrm{p}} }
  \int_{0}^{z_{\mathrm{FRB}}} \frac{(1+z^{\prime})f_{\mathrm{e}}(z^{\prime})dz^{\prime}}
      {[(1+z^{\prime})^3\Omega_{\mathrm{m}} + \Omega_{\mathrm{\Lambda}}]^{0.5}}\;.$$ Here, we take $\mathrm{DM}_{\mathrm{IGM}}=\mathrm{DM}_{\mathrm{FRB}}-\mathrm{DM}_{\mathrm{MW}}-\mathrm{DM}_{\mathrm{halo}}-\mathrm{DM}_{\mathrm{host}}(1+z)^{-1}$ (see Methods). It is appropriate to account for a Milky Way halo contribution[@dgbb15] of $\mathrm{DM}_{\mathrm{halo}}=30\;\mathrm{cm}^{-3}\;\mathrm{pc}$ and we derive $\mathrm{DM}_{\mathrm{MW}}=189\;\mathrm{cm}^{-3}\;\mathrm{pc}$ from the NE2001 Galactic electron density model[@cl02]. An elliptical galaxy can be modelled[@xh15] with a modified version of NE2001 with an average rest-frame value of $\sim 37\;\mathrm{cm}^{-3}\;\mathrm{pc}$. The NE2001 components are uncertain at the $20\%$ level[@cl02], and there is an additional uncertainty of $\sim 100\;\mathrm{cm}^{-3}\;\mathrm{pc}$ due to line-of-sight inhomogeneities in the IGM[@mcq14]. We therefore obtain: $$\label{eq:omega}
  \Omega_{\mathrm{IGM}} = \left(\frac{0.88}{f_{\mathrm{e}}}\right) 0.049 \pm 0.013 \;,$$ where the ionisation factor $f_{\mathrm{e}}=1$ for $100\%$ ionised hydrogen, whereas allowing


                 -2.00(1)
                    \[-2ex\] DM$_\mathrm{MW}$                           $188.5\;\mathrm{cm}^{-3}\;\mathrm{pc}$
                   \[-2ex\] z$_{\mathrm{FRB}}$                                         0.492(8)
 attributes of the speech signal \[[@B9]-[@B15]\].

A majority of earlier studies aimed at investigating cortical responses to degraded speech have used continuous stochastic noise to distort the speech stimuli. Stochastic noise has a random frequency spectrum which does not correlate with the spectral structure of the speech signal. In these studies, the noise was presented continuously in the background, resulting in an elevated recognition threshold for the speech stimuli as the signal-to-noise ratio was decreased. Using continuous low- and high-pass stochastic noise, Martin et al. \[[@B16],[@B17]\] demonstrated that the N1, N2, and P3 responses elicited by speech sounds were delayed and reduced in amplitude as the bandwidth of the masking noise was increased. In a related study, Whiting et al. \[[@B18]\] showed that when speech sounds were distorted with


the distortion, apart from a small decrease of P1m/N1m/P2m latency for the sine-wave stimuli as the quality of the stimuli was decreased. In addition, the AEF latencies were earlier for the sine-wave than for the speech sound and sine-wave composite stimuli, which corroborates previous findings \[[@B32],[@B33]\]. In the behavioral experiment, stimulus distortion was severe enough to interfere with identification accuracy and reaction times only in the most degraded (1-bit) condition. These findings are congruent with the results of Loizou et al. \[[@B4]\] who demonstrated that for vowel stimuli, an amplitude resolution of four levels (2-bit) is required for successful performance in a recognition task, assuming that spectral resolution is sufficiently high.

The current findings on the processing of speech sounds are in accord with previous results \[[@B24]\], which showevoked responses. Soeta et al. \[[@B41]\], for example, demonstrated that the amplitude of the N1m decreased with increasing bandwidth of stochastic noise. Furthermore, Lütkenhöner et al. \[[@B39]\] found that a band-pass random noise elicited a weaker N1m response than a pure tone of narrower bandwidth. In addition, Seither-Preisler et al. \[[@B42]\] did not find any systematic change in the N1m amplitude accompanied with variation in spectral bandwidth of stochastic noise. Similar effects on AEPs have also been documented using continuous masking noise \[[@B16],[@B17]\], the increase in noise bandwidth resulting in diminished AEP responses to speech sounds. Taken together, it seems plausible that the spectral structure of the stimulus has an effect on the related brain responses when the spectral bandwidth of the stimulus is modified. More specifically, it


the responses were stronger and more sensitive to distortion in the right hemisphere than the left. We propose that the observed enhancement of cortical activity is related to the distortion caused by the decrease of the amplitude resolution of the signal, in particular the resulting addition of noisy harmonics over the entire bandwidth of the signal spectrum. Taken together, the present results demonstrate that differences in the spectral structure of signal distortion can have substantial effects on brain responses while the perceptual identification of the signal is compromised in a similar manner.

Abbreviations
=============

AEF: auditory evoked field; AEP: auditory evoked potential; ANOVA: analysis of variance; ECD: equivalent current dipole; EEG: electroencephalography; F0: fundamental frequency; MEG: magnetoencephalography; RT: reaction time; USQ: uniform scalar quantization.

Authors\' contributions
=======================

HT, PA, PM and IM designed the /// <remarks>
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w*l = 19*l - 342. Let o = l + 166. What is the hundreds digit of o?
2
What is the thousands digit of 6493 + (1 + 1 - (156/(-12) - -18))?
6
Let x(c) = 303*c**2 + 9*c - 3. Let h be x(-2). Suppose -5*p + 3149 = -h. What is the units digit of p?
8
Let z = 104 + -102. Suppose 2*k - 2*s = 28, 3*s - 19 - 24 = -z*k. Let l = k - 8. What is the units digit of l?
9
What is the hundreds digit of (-1520)/1330 + 292447/7?
7
Suppose 4*f - 2 = 6. Suppose -f*u - 3*z + 17599 = 6526, -4*z = 4. What is the units digit of u/34 - 22/(-187)?
3
Let g be (22/(-3))/(4/(-6)). Suppose 0 = -37*a +    except Exception as e:
                    msg = "Exception: {}, Retrying in {} seconds...".format(e, delay)
                    print(msg)
                    time.sleep(opt_dict['delay'])
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            return f(*args, **kwargs)

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    return retry_decorator


in turn leads to an increase in the contact rate of humans with rodents, and as a consequence, a higher probability of acquiring LF infection.

Fichet-Calvet & Rogers \[[@RSTB20180268C22]\] previously showed that the rainfall pattern was the main single abiotic factor contributing to LF. The migration of rodents was notified as a main factor in another report \[[@RSTB20180268C23]\]. Our findings confirm the importance of the combined effect of these two factors on the seasonality of LF epidemics and offer a quantitative estimation of their strength, which has never to our knowledge been done in the past. When the rainy season ends in November, the breeding season for rodents starts about two months later. At that time, newly born offspring and scarcity of food on the ground force mature rodentsa stadium that will be comfortable for both the fans and players, so it was crucial that the winning architectural design team understood the challenges and opportunities associated with the Sonoran Desert. We conducted months of analysis with multiple organizations to ensure we were picking the ideal companies for the job and we could not be more excited or confident in this partnership. This announcement represents another milestone in Phoenix Rising’s ‘Rising is Ready for MLS’ campaign.”

Arup, an independent firm of designers, planners, engineers, consultants and technical specialists conducted extensive analysis of the design plans of all three finalist firms. Arup helps clients solve complex challenges such as harsh climates and has conducted a variety of studies on the topic. Additionally, local award-winning construction experts, Mortenson Construction, further


5469, -t = 3*q - 9818. Is q a composite number?
True
Suppose -10*p = -17*p. Suppose q = -2*l + 5, 2*q - 2*l + 2 = 6*q. Is p + q + (-36)/(-3) prime?
True
Is (-9623298)/(-73) - (-1*5 + 2) prime?
False
Is 5919*(-1 - (-374)/33) a composite number?
True
Let a = 6481 - 3072. Is a prime?
False
Is (663 + -6 - -6) + 4 composite?
True
Suppose 16*o - 6 = 15*o. Let i(j) = 19*j**2 - 8*j - 3. Is i(o) composite?
True
Let b(i) = -i**3 + 9*i**2 - 2*i - 7. Is b(-8) a prime number?
True
Let g = 730 - 420. Suppose -z = -3*z + g. Is z a prime number?
False
Is (-8 - (-7 + -6))*18773 a composite number?
True
Let s(w) = -34*w + 32 - 70*w - 35. Is s(-5) composite?
True
LetIs o prime?
False
Let j(a) = -2*a**3 - 3*a**2 + 2. Let y be j(-5). Suppose -4*c = -c + y. Is (2 + 0)/((-2)/c) a composite number?
False
Let o = -1885 - -11868. Is o a composite number?
True
Let b be (30/(-5))/3 - -553. Let m = b + -13. Is m a prime number?
False
Suppose -3 = -5*o + 17. Suppose -o*x + 5*g = -15, 2*x + 11 + 1 = -4*g. Suppose x = -s + 9 + 16. Is s a prime number?
False
Suppose -8*d + 5*d = 0. Let s = 3 - 2. Is s*(387 - (d - 2)) composite?
False
Let r = -16 + 12. Is 321 + r/((-2)/1) a composite number?
True
Is (2/(-3))/(5 + 652203/(-130437)) prime?
True
Let u(p) = 6*p**3 + 4*p**2 + 2*p + 17. Let


n a composite number?
False
Let b(r) = 64*r**2 + 2*r + 1. Suppose -3*p - 2*m = 0, 3*p - 1 = -3*m + 2. Is b(p) a prime number?
False
Let q = 6901 + -2595. Is q composite?
True
Is 7631*(3 + 0 + 2 - 4) composite?
True
Suppose 2*j - 12 = -3*g, 5 + 0 = 5*j - 5*g. Suppose 2*m - 5*q = -19 - 1, 0 = 5*m + j*q - 12. Let b(y) = y + 31. Is b(m) prime?
True
Is (-2*(-2)/(-4))/((-1)/33791) a composite number?
False
Let m = -11 - -17. Let r(g) = m + 24*g - 4 - 7. Is r(3) a prime number?
True
Letis everything and you bought at the right time. You got a great deal and the price you paid is what Over stocked .com lists for a limited today.

I suspect the quality/ safety issue may bring the price down even more depending opon the amount of unsold inventories for this model. The inventories for this model were low before the last round of recalls so only time will tell how this affects the inventory level.

Do you have any second thoughts about buying the vehicle due to the recent recall on this model ?

That's not too bad out the door, though not great (just my opinion though). Granted, I bough my Sequoia LTD just over a year ago, but that said, given all of the "issues" Toyota is having


aired part of the concert on Tidal, the fledgling streaming service backed by rap mogul Jay-Z.

– Showcasing musical roots –

In a show of magnanimity not just political but musical, Prince performed for Baltimore “Don’t Stop ‘Til You Get Enough” by Michael Jackson — often described in the 1980s as Prince’s rival, even if the real extent of their hostility remains a matter of conjecture.

The cover offered a chance for Prince to show off his ever-impressive falsetto. He also demonstrated his voice’s power on “Nothing Compares 2 U,” which was written by Prince but whose most famous interpreter — Sinead O’Connor — recently said she was finished singing it.

Yet Prince’s overall interest during the two-and-a-half-hour show appeared not to be just to excite fans with his hits but to"23.976 English SDH DVD subrip © 09-02-2014" "[ Metal creaks ]" ""It is nice to be able to sail with the lights on without worrying about a U-boat."" ""But don't you miss the excitement?"" " [ Clank!" "] - [ Both gasp ]" "Ah !" " Yah !" " [ Metal creaks ]" "[ Alarm blaring ]" "Uh !" "[ Men shouting indistinctly ]" "[ Blaring continues ]" "[ Roaring ]" ""It is the Kraken!" "We are going to die!"" ""The Kraken!"" "[ Squeaking ]" "Atlantis:" "Milo's Return (2003)" "Woman : 8,000 years ago," "Atlantis sank beneath the ocean." "The Great Crystal, the source of its power, was hidden beneath the city." "Robbed of the heart of Atlantis, my people seemed doomed to slow extinction." "But now we


Hey!" "Ah !" "Two for flinching." "Why, thank you." "Uh, I hope my hay fever doesn't kick up." "Hello." "So, who wants to show me around the city?" " Oh, let me." " I will do it!" " No!" "I saw her first!" " No!" "No!" "Me!" "Me!" "Boys, boys, you're both pretty." "We'll all go." "[ Women laughing ]" "[ Chuckles ] Mademoiselles!" "[ Whispering ]" " [ Gasps ] - [ Gasps ] - [ Gasps ]" "[ Gasps ]" "Jeez, I missed you guys." "Ahhhhh !" "But why are you here?" "I-Is Mr. Whitmore okay?" "Why don't you ask him yourself?" "Milo." "Uh, Mr. Whitmore!" "Not only am I okay, but this Crystal of yours makes me feel 20 years younger." "Whoa!" " [ Grunts"[ Grunts ] I-I can't reach !" "[ Grunts ] I have to jump." "Uh, don't jump." "I'll climb down." "There's no room !" "I have to jump." "Audrey, I'm the team leader, and I order you not to jump!" "Oh, that's it." "[ Grunts ]" "[ Sighs ] See?" " Audrey!" " Aah !" "[ Gasps ]" "You see?" "You cannot live without me." "[ Gasps ]" "Gather the possessions of the strangers and burn them." "[ Obby growling ]" "What's the matter, Volgud?" "You think we've got fleas?" "Gee, you seem surprised to see us." "[ Door closes ]" "Definitely worm or leech." "Salamanders are too cute." "We'd like to hear more about Volgud's deal with the devil." "It is an old wives' story, a folk


through my soul !" "Came screamin' off that ridge like a pack of ghosts!" "I ran back to my shack and bolted the door." "I figured I'd be safe if I stayed inside." "I was wrong." "Scratched me up like a two-sizes-too-small wool sweater on a hot afternoon !" "Luckily I had plenty of bacon grease to rub all over my hide to ease the chafing'." "Dinnertime." "Mr. McKeane, what have we told you about the bacon grease?" "Works better than any of your darned fool fix-'em-ups!" "I stood a better chance with them coyotes." "Is he going to be all right?" "Oh, yes." "We're moving him to the hospital in Scottsdale, where he'll be their problem." "So, where did you find this?" "[ Slurping ]" "In aaway with it." "I knew there was something shifty about you." "Didn't I say so?" "I said, "I don't trust that Carnaby." "Don't like him one bit." "Don't like his attitude, don't like his shifty little eyes."" "And don't forget -- the eyes are the windows to the soul." "Mm-hmm, mm-hmm." "That's right." "I said that, too." "Well, you and your friends will have a long time to discuss how you feel about me while I'm getting rich." "We have found evidence of my people here." "We cannot let him destroy it." "Mr. Carnaby!" "O-Obviously, we've had some sort of miscommunication here." "I-I don't see any reason why we can't work something out." "Ha, save your breath, junior." "You're gonna need it." "Yah !" "Happy trails." "[ Both


Susceptibility to virus infection of transgenic tobacco plants expressing structural and nonstructural genes of tobacco rattle virus.
Tobacco plants were transformed with the coat protein (CP) genes and several nonstructural genes of tobacco rattle virus (TRV) strains PLB and TCM. Accumulation of RNA transcripts from the integrated viral genes was detectable in all types of transformants. Plants expressing CP were resistant to infection with virions of the homologous strain but susceptible to infection with RNA of the homologous strain or nucleoprotein of the heterologous strain. No resistance was detectable in plants transformed with the nonstructural 13K and 16K genes of strain PLB, or with the 29K gene that is unique to RNA-2 of strain TCM. When protoplasts from plants expressing TCM-CP were inoculated with TCM virions, there was ait’s always a special occasion earning your debut in a Formula One car,” said Haas F1 team boss Günther Steiner.

“He has enjoyed a solid 2018 season competing in the FIA Formula 2 Championship, amidst possibly one of the strongest fields in recent years. We look forward to welcoming Louis into the team along with ADSS Group at their home Grand Prix.

“I’m sure he will acquit himself with the same drive and determination that has brought him success throughout his career to-date."


cruises on the ship Hanseatic if booked by Feb. 15.

Seabourn Cruise Line frequently sells out its two 106-cabin luxury ships for its summer routes, said spokesman Ernest Beyl. "We are showing strong sales in Europe, the Med, Alaska and the South Pacific - we are up in sales 45 percent over last year at this time."Beyl added that as of mid-December, there was limited availability in Europe and the Mediterranean in 1996.

Seabourn also offers savings for early bookings: a 5 percent discount for paid-in-full fares six months before sailing and a "share" program offering up to $3,000 per suite savings when two couples travel together on the same sailing. Crystal Cruises is offering savings certificates of $750 per person, $1,500 per couple, on seven European sailings by theare to be based on students grades. This is dangerous as it empowers the student, may lead to teaching the test, cheating, a change in weighting to ensure student success and therefore presenting a picture that the student is ready for college when in reality they are not. I would love to address the higher more noble aspects but in truth there are so many problems with the foundation that if not addressed and corrected the United States will continue to fall in international comparisions such as we have witnessed in the latest PISA exams. Always a pleasure to converse with you.


added a second gene to the mix to improve the efficacy of the virus. They selected the interferon-beta gene because of its immune system significance. White blood cells make interferons, which disrupt the propagation of microbial invaders, and can stimulate immune activity in other cells.

"Both p53 and interferon-beta can kill tumor cells. We wanted to combine them for cell death to wake up the immune system. This is known as immunogenic cell death," Strauss explained.

When a genetic partner of p53 and interferon-beta were delivered to the nucleus of tumor cells, the mouse immune system saw the tumor as an invader and mounted an immune response to destroy it.

"When this happens, the immune system combats tumor cells both at the treatment site and in tumors located elsewhere," Strauss noted.had. Had Tarkovsky and crew kept this film to right around one hundred minutes, hell even two hours, I probably would be lauding it as a masterpiece now. Pieces of classical music played over Kelvin and his wife staring at each other were doing nothing for me and ultimately, nothing was ever solved. In fact, there really wasn't an ending at all was there. Okay, sure, so Kelvin never gets off Solaris and instead simply THINKS he does, but is that really a suitable ending? Will Kelvin spend the rest of his life meeting multiple Hari's forever? Also, wouldn't it have been more appropriate if Kelvin and Hari were madly in love when she died on Earth? Instead, the back story is that they had actually separated and


diversity of man. In all shapes and sizes, he comes. Man has at its core one basis identity: the phallus. It defines our very nature. The phallus unites all human males. We each have a phallus, made in the image of the Great Father. Sex bonds us to our phallus but also to one another. As humans, we must devote our being to cock. Sexual orientation of the devotee is not important. Rather, interaction with cock is integral to his worship and devotion.”

Drew watched and listened to the video. The sedatives Seth slipped into his wine at dinner lulled Drew into a dazed, relaxed mood. He watched the flashing lights of the stars, clueless soaking in all the subliminal messages and images that infiltrated his mind. The starryrather than spending heavily on the channel and marketing.”

Smartphone quarterly estimate and forecast data is taken from Canalys’ Smartphone Analysis service.

For more information, please contact:

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inflating the “balance in full,” or BIF, of consumer debt. Charges filed by the Federal Trade Commission allege the defendants engaged in a practice of providing consumers a “Balance Given” that was

Robert M. Wilson, III

LITTLE ROCK (October 30, 2018) – Wilson & Associates is excited to announce the opening of their Immigration Department, which will be led by Kathleen McDonald. McDonald was the former managing partner of the Beacon Legal Group, a law firm in Little Rock focusing on immigration, cyber law, intellectual property, and personal injury. A native

Wilson & Associates

Since 1953, the U. S. Department of Veterans Affairs has provided a benefit for veterans or their surviving spouses that can be used to pay for home care, assisted living and nursing home costs. Many veterans did notrealizing the importance of mentoring programs, however some mentors commit but cannot follow-through. In order for the mentor relationship to succeed,

Heather Martin-Herron

Tennessee: Foreclosure of Superior Deed of Trust Extinguishes Subsequent Easement Courtney McGahhey Miller The general rule in Tennessee regarding the foreclosure of a superior deed of trust is the purchaser at a foreclosure sale takes title divested of all encumbrances made subsequent to the foreclosed deed of trust. The Court of Appeals of Tennessee recently

Courtney McGahhey

Reverse Mortgage Concerns: Occupancy Determination Posted By USFN, Monday, August 1, 2016 August 1, 2016 by Jillian H. Wilson Wilson & Associates, P.L.L.C. USFN Member (Arkansas, Mississippi, Tennessee) The reverse mortgage is one of the more powerful financial tools available to seniors due to its ability to increase their monthly income at


William Whiting and the Webley company had high hopes for their self-loading pistols being adopted by the British military - but they never got the success they were hoping for.

After the poor performance of the Webley 1904 (https://www.full30.com/video/09e3ddf55d195c53bb44ce747a7b44fc) at trials, William Whiting decided to make sure his next attempt would be fully developed before he put it in the hands of the military. He did very well at that too, as the gun which would become the Model 1913 Webley did very well from its very first military tests. The Royal Navy was, in fact, quite enthusiastic about it, although the Army was not. The Navy would ultimately adopt the gun and purchase about 8,000 of them during World War One, while the Army acquired just a couplemoved for bond. Before hearing evidence or argument, the trial court

recounted the case’s procedural history and commented that Johnston was “renewing his motion

with the same reasons that he presented” in November 2018. The trial court also stated, “this

continuance of roughly four months going forward from today is another issue for the Court to

consider.”

       Johnston proffered, without objection, that many of his family and friends were in the

courtroom and had been “supportive of him through this whole ordeal.” Johnston had “lived in

[the] area his whole life” and had “never been anywhere else.” He proffered that his job at an

automobile repair facility “may still be available,” but if it was not, he could live with his uncle,

who could “put [Johnston] to work with him”


doing home renovation. Johnston claimed that he

had “never been in trouble” and had no criminal history save a reckless driving conviction.

Following that proffer, the trial court questioned Johnston about the exact locations of the

automobile repair facility and his uncle’s residence.

       Johnston did not deny that he had shot and killed the victim but maintained that he had

acted in self-defense. He proffered that a juror from the first trial had called his counsel’s office,

identified herself by name, and stated that the jury had hung eleven to one in favor of acquitting

Johnston. Johnston asked the trial court to grant a reasonable bond but conceded that some

conditions could apply, such as GPS monitoring. The trial court asked what a reasonable bond

would be, and Johnston responded                                 -4-
       “This Court reviews a trial court’s decision whether to grant bail for abuse of discretion.”

Commonwealth v. Duse, 295 Va. 1, 7 (2018) (citing Fisher v. Commonwealth, 236 Va. 403, 411

(1988)). “[T]he abuse of discretion standard requires a reviewing court to show enough

deference to a primary decisionmaker’s judgment that the court does not reverse merely because

the reviewing court would have come to a [different] result in the first instance.” Id. (quoting

Lawlor v. Commonwealth, 285 Va. 187, 212 (2013)).


   and meaningful review of bail decisions, a court making such a
                decision has a duty to articulate the basis of its ruling sufficiently
                to enable a reviewing court to make an objective determination that
                the court below has not abused its discretion.

Id. The duty to articulate the basis for the bail decision attaches, the Supreme Court explained,

because the

                      ‘misapplying the standard of review and finding the rebuttable presumption
against bail had not been rebutted based on the record.’” Shannon, 289 Va. at 203‑04. The
Supreme Court, however, explicitly did not “make an independent determination whether the
circuit court abused its discretion in admitting [the defendant] to bail.” Id. at 204. It observed
that while Rule 5A:2(b) provides that this Court reviews an order setting or denying bail “for
abuse of discretion,” “[t]here is no corresponding rule regarding review of a bail decision in [the
Supreme Court].” Id. at 204 n.1. Instead, the Supreme Court considered de novo “whether the


test unwind
set opt_level=speed_and_size
set is_pic
target x86_64 haswell

; check the unwind information with a function with no args
function %no_args() system_v {
block0:
    return
}
; sameln: 0x00000000: CIE
; nextln:         length: 0x00000014
; nextln:        version: 0x01
; nextln:     code_align: 1
; nextln:     data_align: -8
; nextln:    ra_register: 0x10
; nextln:                 DW_CFA_def_cfa (r7, 8)
; nextln:                 DW_CFA_offset (r16, 1)
; nextln:                 DW_CFA_nop
; nextln:           DW_CFA_advance_loc (2)
; nextln:                 DW_CFA_offset (r13, 5)
; nextln:                 DW_CFA_advance_loc (2)
; nextln:                 DW_CFA_offset (r14, 6)
; nextln:                 DW_CFA_advance_loc (2)
; nextln:                 DW_CFA_offset (r15, 7)
; nextln:                 DW_CFA_advance_loc (102)
;


purity test?" "Aw, it's this online list of questions of everything you could possibly do that's dirty or fun or illegal:" "have you smoked pot, have you ever shoplifted..." "Have you ever done a reverse cowgirl?" "And then it tallies up your answers and gives you the score of what percentage pure you are." "The lower score, the badder you've been." "So if you get a 60, you're 60% pure, 40% sack jockey." "Anything under 60's really slutty." "Unless you're a guy." "It was emailed to the whole school." "Everyone's taking it." "What'd you score?" "Uh, 91." "Dude, Snow White took it and scored an 89." "I think it's sexy we decided to wait." "All right, Cole." "Kissing on the lips now." "Somebody describe second base to me."Neptune." "Now there have to be lots of respectable kids in your school." "I don't want you spending all your time with Veronica Mars." "I'm an angel." "I'm hot." "Straight from heaven." "Did she invite me for supper?" "Aw no, it's no big deal." "There aren't many girls she caught flashing me." "Listen to this." "Not that innocent?" "Buy the results of anyone's purity test." "Ten dollars will let you know if you're dating an angel from heaven or a hottie from hell." "That's crazy." "You can go on there and buy anyone's test?" "I never thought I'd say this." "But I kinda can't wait for school tomorrow." "I knew when you came back from Spain last summer, there was something different about you." "Should have guessed you


"You know his schedule by heart." "I do a lot of computer stuff." "Plus you'll understand when you see him." "Cool." "Thanks." "Yeah and if Rene can't help you let me know 'cause I might be able to find a way to sneak into the system and get you some answers." "That's really criminal." "Thanks." "Why are you holding your hands like that?" "So that one day in your memoirs, you'll describe me as inscrutable." "I was leaning more toward bonkers." "I'll take what I can get." "Ah, I guess I'll get that." "It's been over two months now and no rent." "You've been really great and I appreciate it." "I'm tired of being great, you know, I have my own bills to worry about." "Listen, can wetime I make a move, I get this yappity yap in my face." "Yeah, all right then." "Let's get this yappity yap" "Whoa, whoa." "Hold on, son, hold on." "Go ahead." "Go ahead, make your dinner." "Come with me Wallace, come on." "You-you set an example for your brother, now." "That's exactly what I plan on doing, ma." "Listen to me, listen to me, come on." "You ready to put the hurt on that Pythagorean Theorem?" "Oh, you don't even wanna mess with me on that today." "I just about murc'd my mom's crazy, no-rent-paying tenant this afternoon." "That guy's sleazy so I hope "murc'd" means something bad." "You know, my dad's still got that Sheriff sheen." "He's great at scaring people away." "No, I got it covered."


test for you." "She hates you because Duncan is still hung up on you." "Note to self, cue tape for client." "I only posted Meg's, I swear." "Why would you do that?" "She gets everything I want." "Everything." "The lead in the musical, cheerleader, the anchor job." "Thanks, Kimmy." "What did you" "And last night's lacrosse match with the Point Pleasant Raiders..." "You dumb wanna-be freak show." "I had to tell her." "Of course you did." "Because you're spineless." "Please start crying 'cause you're not pathetic enough already." "Nice hair cut by the way." "Does Meg know you bring her picture to Fantastic Sam's?" "Very dramatic, Kimmy." "Very Meg." "What?" "All fours, huh, Dick?" "You mess with the bull." "There was really only one person smart enough toin?" "Oh." "I know who you are Veronica Mars." "I knew your mom when she used to visit the office during lunch hours." "I don't believe you." "You're a very dedicated young lady." "Certainly you didn't inherit that quality from poor scattered Lianne." "Unfortunately for you, that makes you your father's daughter." "My dad tried to save your life." "I meant your real father." "Think about it Veronica." "Look in a mirror." "Are you the product of a schluppy sheriff or the king and queen of the prom?"


in possession of a firearm, one count of being a felon in possession of ammunition, and two counts of actively participating in a criminal street gang.
With respect to the assault convictions, the jury found true great bodily injury and personal firearm allegations. With respect to one of the assault convictions and one of the firearm possession counts, the jury found gang participation allegations true.
Mesa does not challenge his convictions on the substantive counts or the sufficiency of the evidence supporting the enhancements. Nonetheless, Mesa raises a number of sentencing issues. First, he contends, and the Attorney General agrees, that with respect to one of the assault convictions, the trial court erred in imposing the gang enhancement. As Mesa points out, Penal Code[2] section 1170.1, subdivsions (f) and (g),chief source of terror created by street gangs. The Legislature further finds that an effective means of punishing and deterring the criminal activities of street gangs is through forfeiture of the profits, proceeds, and instrumentalities acquired, accumulated, or used by street gangs." (§ 186.21, italics added.)
(4) Given these findings, the Legislature enacted section 186.22, subdivision (a), which makes it a crime to participate in street gang activity. Section 186.22, subdivision (a), states: "Any person who actively participates in any criminal street gang with knowledge that its members engage in or have engaged in a pattern of criminal gang activity, and who willfully promotes, furthers, or assists in any felonious criminal conduct by members of that gang, shall be punished by imprisonment in a county jail for a period


committed on behalf of the gang. The perpetrator of the underlying crime may thus possess "two independent, even if simultaneous, objectives[,]" thereby precluding application of section 654. [Citation.]' [Citation.] At this point, the court found sufficient evidence that the defendant `intended to aid his gang in felonious conduct, irrespective of his independent objective to murder.' [Citation.]
"Finally, the court added: `[I]f section 654 were held applicable here, it would render [Penal Code] section 186.22, subdivision (a) a nullity whenever a gang member was convicted of the substantive crime committed in furtherance of the gang. "[T]he purpose of section 654 `is to insure that a defendant's punishment will be commensurate with his culpability.' [Citation.]" [Citation.] We do not believe the Legislature intended to exempt the most culpable parties from theconstituted a criminal course of conduct with a single intent and objective. That single criminal intent or objective was to avenge [a fellow gang member]'s killing by conspiring to commit murder. Although that intent or objective could be parsed further into intent to promote the gang and intent to kill, those intents were not independent. Each intent was dependent on, and incident to, the other.' [Citation.]" (People v. Sanchez, supra, 179 Cal.App.4th at p. 1312, fn. omitted.)
In People v. Sanchez the court rejected the reasoning and holding in People v. Herrera and accepted the holding, but not the reasoning, of the court in People v. Vu. In People v. Sanchez the defendant was convicted of both committing a robbery with a confederate and participating in a street gang


From Colombia with Love: Commendable Cannabis Approaches from around the World

It’s been nearly a year since Canada lifted the federal ban on cannabis, but many issues around the production, distribution, sale and use of the plant remain hazy at best. Questions around personal cultivation, where to consume and the legal status of CBD and edibles are still looming.

There’s still a lot of work to do, so maybe it’s time that we get a little help from our friends.

Although Canada looks to other countries for supplying things like electricity, motor vehicles and consumer goods…it hasn’t done the same for cannabis.

Here are the top three countries with commendable cannabis concepts that Canada should consider importing.

1) Colombia

It may surprise some cannabis connoisseurs to see Colombia as first on this list, givenof cannabis-users with the safety of the community at large. There are now strict packaging rules in place, which all new THC-laced products must abide by. These include ensuring that packages are not bright, colorful or otherwise appealing to children, in addition to being clearly marked as “Not for Kids.”

The important take-away here though, is that the products themselves have not been restricted or compromised.

Manufacturers are free to make cannabis-laced edibles in any shape, size or form, from infused rainbow candy belts to malted milkshake chocolate balls. And the cherry on top of the marijuana-laced dream is that products can also contain up to 10 mg of THC per serving and 100 mg per package.

Compare this to the proposed regulations around edibles here at home, in the Land


and the intermediate transferring body 8, simultaneously.
The transferring rollers 12a abut intermediate transferring body 8 while transferring the color visible images in superposition onto the intermediate transferring body 8. When finishing the print processing, however, the transferring rollers 12a are shifted to positions 12b depicted by a broken line in FIG. 6, thus separating the transferring rollers 12a from the intermediate transferring body 8.
The fixing section 9 fixes the transferred color visible images onto the transferring material 2 while conveying the transferring material 2. The fixing section 9 includes fixing rollers 13 for heating the transferring material 2, and pressurizing rollers 14 for bringing the transferring material 2 into a press-contact with the fixing rollers 13. The fixing roller 13 and the pressurizing roller 14 are hollowed andand a discharging sensor 24, which are disposed on a transferring material conveying path.
The numeral represents a cleaning means for cleaning residual toners on the photosensitive bodies 4Y, 4M, 4C, 4K and on the intermediate transferring body 8. Waste toners after transferring onto the intermediate transferring body 8 the visible images formed by the toners on the photosensitive bodies 4Y, 4M, 4C, 4K or waste toners after transferring onto the transferring material 2 the four-color (Y, M, C, K) visible images formed on the intermediate transferring body 8, are accumulated in an unillustrated cleaner container.
The numeral 26 designates a discharging option including rollers 27, 28, 29, 30, a flapper 31, a first discharging bin 32, a second discharging bin 33, a third discharging bin 34 and a bin


the print operation (sequence) according to the scheduled print command of the first sheet (step S803).
The engine control part 203, if a next scheduled print command is not received (step S805) till a next print operation start timing (which will hereinafter be referred to as a normal print start timing) for maintaining a throughput (step S804), executes post-processing (which will hereinafter be termed a post-rotation sequence) of the print operation (step S809), and thereafter finishes the present print operation.
While on the other hand, if the next scheduled print command is received (step S805) till the next normal print start timing (step S804), and if a print start command for the scheduled print command is received (step S806), the engine control part 203 starts the print operation of thestarts the print operation of the second sheet subsequent to the first sheet by outputting the /TOP signal 2 (S1022) at the normal print start timing of the second sheet (S1002), and conveys the transferring material to the discharging option 206 from the duplex unit.
Thereafter, the engine control part 203, in the case of receiving the scheduled print command and the print start command of the next page till the normal print start timing, continues the consecutive printing by outputting the /TOP signal.
While on the other hand, in the case of receiving neither the scheduled print command nor the print start command of the next page till the normal print start timing (during a period of S1006–S1007), the engine control part 203 starts the post-rotation sequence, and finishes


in the case of stapling during the duplex printing in the printer P shown in FIG. 6.
The controller part 201 alternately transmits, to the engine control part 203, the scheduled print command from the transferring material cassette 1 to the duplex unit and the scheduled print command from the duplex unit to the discharging option 26 (S1111, S1112, S1113, S1114, S1115, S1116). Then, the controller part 201 transmits to the discharging option control part 202 a scheduled discharging command 1 in S1101, a scheduled discharging command 2 in S1103 and a scheduled discharging command 3 in S1105, respectively.
The controller part 201, when transmitting the scheduled discharging command 1 in S1101, the scheduled discharging command 2 in S1103 and the scheduled discharging command 3 in S1105, acquires from theat the normal print timing.
Concerning the third sheet, i.e., “a transferring material corresponding to a scheduled print 6 in S116”, discharged to the discharging option 26, however, the print of the third sheet can not be started during a period, i.e., “a period of a discharging interval 2 (A)”, for which the discharging option 26 can receive the third sheet with an end of stapling of the second sheet, i.e., “a transferring material corresponding to a scheduled print 4 in S1114”.
Accordingly, the controller part 201 is required to transmit the print start command of the third sheet of “transferring material corresponding to the scheduled print 6 in S1116” so that a print interval between the second sheet of “transferring material corresponding to the scheduled print 4 in S1114”


(IA) in the BABYDIET cohort and in the MIDIA study \[[@CR15], [@CR16]\]. On the other hand, they were not associated with T1D in the DAISY cohort \[[@CR17]\]. Gastrointestinal illnesses at precise periods were associated with higher risk of IA in the same study. More recently, the gut microbiome has been investigated in search of a bacterial composition that could be associated with T1D \[[@CR18]\].

Nutrition has been the other focus of environmental research for T1D. Overfeeding and the ensuing increase of beta cell functional activity for producing more insulin has been suspected to favor autoimmunity towards the beta cells (the overload hypothesis) \[[@CR19]\]. Meta-analyses have found that early weight gain \[[@CR20]\] or obesity \[[@CR21]\] showed a modest association with T1D. Vitamin D supplementation studied through questionnaires has been suggestedlist of environmental markers for which false discoveries are controlled.

Methods {#Sec2}
=======

Questionnaire {#Sec3}
-------------

The questionnaire was built by a group of academics composed of obstetricians and pediatricians specialized in pediatric infectious diseases, nutrition, and lifestyle. Their task was to define the environment of pregnant women, neonates, infants and young children, by enumerating all aspects that they thought a mother will likely be able to recall years later. A group of mothers of young children (living in urban or rural environment) were also asked to participate. A first questionnaire of nearly 1000 questions was built and tested across 100 young mothers. Only questions that could be answered rapidly were kept, because we considered that the speed of the answers would favor spontaneity and minimize recall errors and bias. The questionnaire was


from 90 to 120 min. A PDF version of it in French is available as Additional file [1](#MOESM1){ref-type="media"}.

Data collection {#Sec4}
---------------

The Isis-Diab cohort is a large multi-centric cohort of T1D patients in France which recruitment started in 2007. Starting in March 2010, three copies of the questionnaire were sent to the parents of 6618 T1D patients enrolled in the cohort during the month following their inclusion in the study. Parents were asked to fill the questionnaire regarding the exposures and events having taken place in their child's life before the clinical onset of T1D. They were also asked to enroll as controls two of their friends having an unaffected child of the same age. The 6144 parents having provided a phone number were contacted once during the week following thequestionnaire sending. If the questionnaire was not returned within 3 months, parents received a reminder by mail.

One thousand seven hundred sixty-nine cases (i.e. 27 % of the patients to which a questionnaire was sent) and 1085 controls returned the questionnaire. Two hundred forty-one cases provided two controls, 451 cases provided one control, and 1077 cases provided no control. One hundred fifty-two controls were not associated to a case that returned his questionnaire. All the questionnaires completed by patients and controls were seized by a private provider (numerical input for all the « checkbox » responses, and dual manual entry for handwritten responses).

Patients living in areas with higher economic deprivation were less likely to respond \[[@CR31]\].

The questionnaire investigated the period preceding diagnosis of the disease. Matched controls were asked to fill


level of 5 %.

We report the list of variables that passes both the FDR threshold for the matched analysis and the Bonferroni threshold for the propensity analysis. This provides better control over false positives than considering only one of the two thresholds. We also report results for variables associated with T1D in the literature.

Results {#Sec15}
=======

Demographic and quality indicators of the two samples are available in Table [1](#Tab1){ref-type="table"}.Table 1Characteristics of cases and controls in the two samplesMatched analysis samplePropensity analysis sampleCasesControlsCasesControlsNumber4696241151689Age (years)7.5 (4.2;10.5)7.7 (4.6;10.5)7.6 (4.2;10.6)7.8 (4.6;10.5)Delay (years)3.0 (1.0;5.2)2.9 (1.1;5.2)2.9 (0.9;5.6)3.0 (1.1;5.4)Missing data (%)4.4 (2.7;6.8)3.9 (2.5;6.0)4.9 (3.1;7.5)3.8 (2.4;5.9)Age is the reference age. Delay is the time between the diagnosis date and the questionnaire reception. The values displayed are the median value and the first and third quartile between parentheses

Matched analysis {#Sec16}
----------------

For(e. g., above average, average, below average, etc.) and then selects few cases for in-depth understanding within each strata based on purposive sampling. In the sequential sampling method, i. e., quantitative can lead to the sampling of qualitative or qualitative can lead to the sampling for quantitative. The research question leads to the design of sequential mixed method and then one method leads to the other. The literature on mixed method studies in health have good number of examples where this sampling technique has been used.([@ref24]) Although there are less examples of concurrent sampling technique wherein both the samples (qualitative and quantitative) are decided independent of each other to meet the requirement of the research. This sampling method has also provided good results. Similarly, in multilevel sampling, one


bring the users' perspective to the fore.

In the recent past, public health has witnessed a paradigm shift from only delivering the interventions to understanding the health behavior of people, especially to prioritize options on how the risk behaviors can be addressed to reduce harm.([@ref30]) Mixed method research approach may provide some directions in this regard for formulation and evaluation of health communication strategy. Putting the knowledge into practice or translational or implementation research to enhance health equity, that is, reducing health status differences between and within population groups, is another area where mixed method research can lead to formulation of policies that enhance access to effective care by provision of user-friendly public health services to those who need it most.

Conclusions {#sec1-7}
===========

Public health deals with several complex situations fromwomen with BD prior to treatment. In addition, many of the psychotropic medications used in the treatment of BD are associated with weight gain, insulin resistance, and dyslipidemia. These metabolic side effects further compound the neuroendocrine system dysregulation in women with BD. Current understanding of the reproductive and metabolic function in women with BD points to vulnerability, which in turn increases the risk of later-life cardiovascular disease and diabetes, among other morbidities, for women with BD.


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Words Have Their Own Life

By: Rev. Suzie Chamness

Most of the time I can believe that what I say to the people I talk and share with is kind and gentle but if I really sit with that for a time, I, like many of you, might find that what sounds like kindness to our ears is painful to others.

My theory is that most people speak before thinking. Most of the time the thought pops into our head and it comes out our mouth before a second has passed. I know the human mind is amazing but do you really know what you say each time you speak or better than that, would you remember what you said yesterday to a friend and colleague?

There is a sayingvalue of the specific gravity. The rigid columns are received in the resilient tubular members, and the resilient tubular members are inserted into the holes formed in the key through a press fitting.
The resilient tubular members are well fit in the holes. However, the rigid columns are merely held in the resilient tubular members by the agency of the resiliency of the resilient tubular members. In case where the rigid columns are finished smaller than the design drawing, the rigid columns are liable to be dropped out from the resilient tubular members.
Yet another key balance pieces are disclosed in Japan Patent Application laid-open No. 2001-154661. The key balance pieces disclosed in the Japan Patent Application laid-open is made of composite material, and small semi-spherical projections are formed on


a shield, not as a sword; thus, it is available only as an affirmative defense, not an affirmative cause of action as the Whites were attempting to use it.
[¶8] After a hearing, the district court granted the motion for summary judgment. The court concluded the Whites used the disputed strip of land in a manner sufficient to put Ms. Gillett on notice of adverse use. More specifically, the court concluded the Whites used the strip of land for over ten years and their use was open, notorious, visible, exclusive and hostile. The district court entered an order consistent with its decision.

STANDARD OF REVIEW
[¶9] When reviewing an order granting summary judgment, we consider the record de novo. Hincks v. Walton Ranch Co., 2007 WY 12, ¶ 7, 150 P.3dand not as a sword, or an affirmative cause of action.
[¶11] The Whites respond that they satisfied the requirements of adverse possession by their continuous use of the property since 1988 and Ms. Gillett is too late to rely on the ten year statute of limitations. They also claim the fence clearly is not one of convenience because there is nothing on the terrain that would require the fence to vary from the true boundary. Finally they argue the district court properly granted summary judgment because Ms. Gillett did not present evidence showing the existence of a genuine issue of material fact.
[¶12] We consider first Ms. Gillett's claim that adverse possession is available only as an affirmative defense and not as an affirmative cause of action. On that


in the Town Center, that allows you to quickly get a bunch of Slaves, while the cost of the tech gets bigger every time. You will pretty soon find yourself paying much more than what the units are worth for your villagers, so plan ahead, and don't let them die, because they are expensive

Historical discussion: Historical responsibility, and video-games.
It's actually been some fuss about the fact that we included slaves in the game, and with reason: Age of Empires III features european relations with natives in such a friendly way that it is embarrasing and, usually, this topics are not easy to handle. We get that. On the other hand, we have to be faithful to history, and this doesn't mean we have to create a simulator nor

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A:

My jSpinner does not reflect the value to JLabel when I change the
  value using keyboard.

don't to use KeyListener for Swing JComponents, KeyListener doesn't react correctly to BackSpace, nor for inserted array of chars from ClipBoard (copy -> paste)
use DocumentListener added to derived editor JTextField/JFormattedTextField from JSpinner,

A:

I did in this way , I right click on jSpinner in design view and customize the


the lack of a functional germ line and sterility \[[@pgen.1007219.ref018]\]. The analysis revealed that the expression level of WT~Phe~ up::WT~Stv~ down genes was substantially decreased in *glp-4(bn2)* compared to wild-type, indicating that these genes have germline enriched expression ([Fig 1D](#pgen.1007219.g001){ref-type="fig"}). In contrast, WT~Phe~ down::WT~Stv~ up genes exhibited comparable expression levels in wild-type and *glp-4* germline-deficient worms ([Fig 1E](#pgen.1007219.g001){ref-type="fig"}), suggesting that expression of these genes is enriched in somatic tissue. These trends in expression were further supported by examining the overlap of seesaw genes with tissue-enriched gene lists \[[@pgen.1007219.ref019]\], which revealed that 73% of WT~Phe~ up::WT~Stv~ down seesaw genes were germline-enriched ([S3C and S3D Fig](#pgen.1007219.s014){ref-type="supplementary-material"} and [S3 Table](#pgen.1007219.s014){ref-type="supplementary-material"}). Lastly, we used the gene function descriptions in WormBase (WS253; \[[@pgen.1007219.ref020]\]) consisting of published observations, GO annotations, tissue expression data, modENCODEbrood size, the number of surviving progeny produced by the *csr-1* hypomorph remained slightly higher in PD~Phe~ compared to CON~Phe~ ([Fig 6A](#pgen.1007219.g006){ref-type="fig"}). However, the decrease in brood size between postdauer and control adults was abrogated in *csr-1*~Stv~ ([Fig 6B](#pgen.1007219.g006){ref-type="fig"}). We also observed that *glp-4(bn2)* adults grown at the permissive temperature no longer exhibited a decrease in postdauer brood size in the starvation condition ([Fig 6B](#pgen.1007219.g006){ref-type="fig"}), but continued to show an increased number of progeny in the pheromone condition ([Fig 6A](#pgen.1007219.g006){ref-type="fig"}). Recently, GLP-4 was shown to be expressed in the intestine and somatic gonad in addition to the germ line \[[@pgen.1007219.ref041]\]; thus, our observed *glp-4* PD/CON brood size phenotype at the permissive temperature suggests that GLP-4 function in the intestine or somatic gonad is contributing to the regulation of


To test our hypothesis, we first examined the expression of WT~Phe~ up::WT~Stv~ down seesaw gene, *gld-1*, using a *gld-1*::*gfp* transgene expressed in the germ line. To compare developmentally synchronized animals, we examined GFP levels of postdauer and control animals that experienced either pheromone or starvation conditions and exhibited the vulva morphology characteristic of L3, L4.1, and L4.4 larval animals \[[@pgen.1007219.ref047], [@pgen.1007219.ref048]\], at which times the mitotic and transition zones are evident \[[@pgen.1007219.ref043]\]. Although we were unable to validate the seesaw changes in *gld-1* expression using qRT-PCR ([S4C Fig](#pgen.1007219.s004){ref-type="supplementary-material"}), we observed that GFP levels in the germ line were significantly increased in PD~Phe~ larva compared to CON~Phe~ larva at all stages, consistent with our RNA-Seq results ([S8A and S8B Fig](#pgen.1007219.s008){ref-type="supplementary-material"} and [S11 Table](#pgen.1007219.s022){ref-type="supplementary-material"}). In contrast, we detected no significantposit a model whereby different "programs" regulate global changes in gene expression leading to distinct reproductive phenotypes. In animals that experience early life high pheromone condition, the changes in PD/CON mRNA levels in the germ line and soma are dependent on SID-1 function in the soma. In contrast, in postdauer animals that experience early life starvation condition, the observed gene expression changes in the germline and the soma are not dependent on SID-1, but are instead dependent on an unidentified signal(s) from a functional germ line. Our data indicate that these two programs maintain a functional balance within the animal, such that when one program is disrupted by mutation (e.g. *glp-4(bn2)* mutant), the animal exhibits the gene expression and reproductive phenotype of the alternate program (Figs [3](#pgen.1007219.g003){ref-type="fig"}, [4](#pgen.1007219.g004){ref-type="fig"},


[6](#pgen.1007219.g006){ref-type="fig"}, [S4](#pgen.1007219.s004){ref-type="supplementary-material"}, [S5](#pgen.1007219.s005){ref-type="supplementary-material"}, [S6](#pgen.1007219.s006){ref-type="supplementary-material"} and [S7](#pgen.1007219.s007){ref-type="supplementary-material"}). In addition, both programs are dependent on the CSR-1 RNAi pathway for these chromosomally-regulated gene expression differences to result in reproductive plasticity of adult animals ([Fig 7](#pgen.1007219.g007){ref-type="fig"}). Moreover, we provide evidence that genes with similar trends in expression levels in response to pheromone and starvation conditions are co-localized on specific chromosomes, and may have contributed to the evolution of the *C*. *elegans* genome.

![Distinct early life histories result in different gene expression programs and reproductive plasticity in adults.\
(A) *C*. *elegans* life history trajectory is dependent on the environmental conditions experienced during L1 larval stage. CON refers to control adults that did not experience environmental stress. Postdauer adults transiently passed through the dauer stage due to starvation (PD~Stv~) or overcrowding (PD~Phe~) conditions. (B) PD*csr-1* PD~Phe~, (G) *csr-1* CON~Stv~, and (H) *csr-1* PD~Stv~ are shown. Pearson correlation coefficients (r) are indicated.

(TIF)

######

Click here for additional data file.

###### PCA for RNA-Seq library replicates.

PCA was based on the total exon reads per gene, across 21666 genes. Significance of PC loadings per sample was assessed using the FactorMineR dimdesc function \[[@pgen.1007219.ref086]\]. Significance of PCs was assessed using both the Kaiser criterion and the broken stick model \[[@pgen.1007219.ref087]\]. For both the A) wild type and B) *csr-1* hypomorph PCA, only PC1 was significant using either test.

(TIF)

######

Click here for additional data file.

###### Comparison of differentially expressed WT~Phe~, WT~Stv~, *csr-1*~Phe~, *csr-1*~Stv~ seesaw genes and a germline-enriched data set.

(A, B) Venn diagrams depicting the overlap between WT~Phe~ and WT~Stv~ DE genes. (C, D) Venn diagrams of the distribution


and Stv (PD~Stv~/CON~Stv~).

(TIF)

######

Click here for additional data file.

###### qRT-PCR gene expression profiles in *sid-1(qt9)*.

(A-C) qRT-PCR measurement of mRNA levels for (A) soma-enriched, CSR-1-targeted genes, (B) soma-enriched, non-CSR-targeted seesaw genes, and (C) germline-enriched, CSR-1-targeted genes in *sid-1(qt9)*. Measurements were performed in triplicates using three biologically independent samples. Error bars represent S.E.M. \* *p* \< 0.05, \*\* *p* \< 0.01, \*\*\* *p* \< 0.001, \*\*\*\* *p* \< 0.0001; Student's *t*-test comparison of Phe (PD~Phe~/CON~Phe~) and Stv (PD~Stv~/CON~Stv~).

(TIF)

######

Click here for additional data file.

###### GLD-1::GFP fluorescence and gonad arm area in larval stages.

\(A\) Representative images of one gonad arm expressing GLD-1::GFP of CON and PD larva that exhibited larval L3 stage vulva morphology in Phe or Stv conditions. The dotted line indicates the outline of the germ line; arrowheads indicatesworms depicted in the L4.1 and L4.4 DAPI-stained images are from the same trial as the live worms shown in (A). L3 and L4.1 DAPI images were taken at 630X magnification, and L4.4 DAPI images were taken at 400X. The dotted line indicates the germ line; asterisk indicates the distal tip cell; MZ, mitotic zone; TZ, transition zone; PZ, pachytene zone; SC, spermathecal cell (part of the somatic gonad).

(TIF)

######

Click here for additional data file.

###### Representative images of DAPI-stained gonad arms in Stv conditions.

\(A\) Representative gonad arm images of live CON~Stv~ and PD~Stv~ animals at L4.1 and L4.4 stages with their corresponding vulva morphology in the insert. (B) Images of DAPI-stained gonad arms of CON~Stv~ and PD~Stv~ worms at the L3, L4.1 and L4.4 stages. The worms depicted


file.

We are grateful to Roy Welch and Michael Bradley for assistance using CLC Genomics Workbench. We are thankful to Yiqing Guo for his generous help with RNA-Seq libraries; to Arjumand Ghazi, Eleanor Maine, and Scott Pitnick for critical reading of the manuscript; and the BS1080 strain was kindly provided by Tim Schedl. The *Caenorhabditis* Genetics Center provided the strains used in this study and is funded by NIH Office of Research Infrastructure Programs (P40 OD010440).

[^1]: The authors have declared that no competing interests exist.
for 1 h, and incubated with the anti-Panx1 serum (1:100) for 2 h. After that, cells were washed several times with PBS and incubated for 1 h with α-CY2-labeled secondary anti-rabbit antibody (1:1000). After several washes with PBS, cells were incubated with DAPI (5 μg/ml) for 15 min. Finally, coverslips were washed and mounted with Dako fluorescent mounting medium (Dako, Glostrup, Denmark). Stained cells were visualized with a Nikon C1 Plus laser-scanning confocal microscope, equipped with a 100X objective NA 1.30 and excited with laser line 408 and 488 nm. To determine if Panx1 is localized at the plasma membrane, cultured chromaffin cells were labeled with extracellular biotin. Cells were first washed in PBS (pH 7.4) and incubated 10 min with a solution of Kreb's Hepes containing 90


was exposed to such a powerful, profound method or recovery. I was very fortunate. I was brought back from the dead. It was a few years ago but I wanted to communicate that because there are a lot of people struggling with addiction. I wanted to find a way to put that out there in plain man’s language to let people know that there is hope out there.

You mentioned the song, "Save a Prayer." Do you remember when it was written?

I do remember that song coming into being. I was coming into the rehearsal room and Nick and Andy were involved in taking a relatively simple four chord progression and sequencing it. We had an early Roland sequencer at the time and the song was built from that          </group>
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I have used group-adjacent instead of the group-by (shown in https://stackoverflow.com/a/7320527/252228) as that way the solution adapts better to streaming with Saxon 9.8 EE or Exselt
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chips. The EPA requires cellulosic ethanol to have at least a 60 percent reduction of lifetime emissions compared to gasoline, but in 2016 the requirement for this fuel is just 230 million gallons (0.13 percent).

We're doing better with what the EPA terms "advanced biofuels" (which use sugarcane, bionaptha, or biobutanol) that have a 50 percent reduction in lifetime emissions, at 3.6 billion gallons (2 percent) in 2016. However, the overwhelming majority of ethanol in the US fuel supply still comes from corn, for which the EPA requires at least 20 percent less lifetime carbon emissions. Whether any of these figures accurately reflect real-world impacts on carbon emissions is unclear.

Congress tasked the EPA with setting targets for renewable fuels in the 2007 Energy Independence and Security Act, although theworking throughout Los Angeles. None of these spies was professional. At $30 per week, none was going to get rich. But each had his motives for despising Hitler’s Germany or for loving the idea of America, and all knew perfectly well that in winning the trust of those who wished to overthrow the government of their country they were risking their lives—and one of them, Julius Sicius, seems to have lost his in the cause.

Their tasks were to discover what they could, to sow dissension among the leaders and members of the groups they had joined, and ultimately to make it impossible for those dreams of [Hitler taking over the U.S.] come true. The first thing they discovered was that those dreams were not half-baked fantasies. Many of


show all the cool little spots that turned out nice.

29 comments:

LUV LUV LUV this, Karen! Thank you for such a wonderful tutorial on painting and staining. I'm always a little wary of staining over my painting project - but now you have banished that fear and I will step forward ..... and stain! lol!

Great tutorial. One day I'm going to be brave enough to try this! If you have a moment, I would love for you to share this project on my Inspiration Board. http://carolynshomework.blogspot.com/2011/07/inspiration-board-link-party_19.htmlThanks for the inspiration.carolyn | homework  }
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             .interpolate("linear")

graph = d3.select("#graph").append("svg:svg")


in science." "Medicine has a way of exposing the lies." "Within the walls of the hospital, the truth is stripped bare." "How we keep our secrets outside the hospital..." "Well, that's a little different." "George." "You locked the door." "I need to take a shower." "Uh, uh, I'll be out in a minute." "What are you doing in there?" "It's private." "Oh." "Oh, God." "I'm sorry." "I get it." " I don't mean to interrupt." " No, it's not that!" "It's OK." "Take your time." "I am not doing what you think I'm doing." "There's really no need to explain." "I'll wait." "You just... finish." "No, I'm..." "I'm coming." "I'm coming out!" "One thing is certain." "Whatever it is we're trying to hide, we're never ready for that"I appreciate you doing this, Preston." "I know this is a little out of your field." "That's not a problem." "It gives my interns something to do." "I have a feeling you keep them plenty busy." "We were in the same frat at Tulane." "It's gone from torturing pledges to torturing interns." "Am I right?" "Be very careful how you two answer that." "I could tell some stories." "Bill, you have a camera snaking up your mojo." "It's not the time to cross me." "It isn't anything too serious?" "That's what this procedure will tell us." "You don't worry about anything but growing my godson in there." "He kicks like you wouldn't believe." "A badass, just like his father." "Move a little to the right." "Your other right."