is important, but it's not the only thing generating income for a retail petrol station."

In Britain, where DCC is the top oil distributor and operator of fuel loyalty cards, Mr Murphy sees the threat of Brexit as a headache, but not a deterrent to increased investment.

"The UK in a hard Brexit situation has to become a harder market for a time. But it's always going to be a very big market and therefore a good place for us to do business," he said. "We buy from the refiners and importers. Fuel will get into the market because the economy would grind to a halt if there wasn't fuel in it."

Irish Independentthe Jiu Valley to Bucharest to force the government to change its policy, demand wage increases and re-opening of recently closed mines.

Along the way the caravan of miners fought pitched and bloody, tear-gas choked battles with the Gendarmerie and wreaked havoc along the way. The army was mobilized and waited on the outskirts of Bucharest. The anticipated and dreaded showdown between the miners and army, however, never materialized. The miners had not reached Bucharest when a secret compromise was reached between union leader Cozma and Prime Minister Radu Vasile on 22 January.  In return for the miners’ agreement to turn around and go back to the Jiu Valley, the government agreed to a 30 percent pay rise, re-opening of two previously closed mines, and the spending of


is a good idea seeing that they are crafted out of high-quality plastic without any metal parts on the front. The modular sockets are generally shuttered which make them apt to use with children.

Versatile & Multi-Functional – Versatility is the term that goes well with modular switches. These switches can be used for different applications, like automation, signaling, security and data transmission. You can install different types of switches in different parts of a building for different applications. As they are available in many capacities, Modular switches can actually be used for heavy-duty applications too. These switches offer immense flexibility as they can be easily added to, or removed from, the switch plates according to the specific requirements.

Efficient & Ergonomic – Modular switches are very efficient. Generally companiesparticularly as the virus spreads in the U.S.

The outbreak, Omenka said, normally will stop "when it runs out of susceptible hosts, once already infected persons start developing immunity against the agent, or a vaccine becomes available."

The key, he said, is how much the public follows guidelines keeping them apart.

"It cannot be overemphasized the importance of not only public cooperation, but the need for a nationally coordinated response to this outbreak, because it would be horrible if some states experience a resurgence of the disease after overcoming it, due to outbreaks in other states," he said.

The patchwork nature of the U.S. response was underscored by widely divergent assessments in individual states.

While the governors of Illinois and New York issued stay-at-home orders for residents as early as March 20, Florida


you have symptoms and want to get tested, the CDC recommends calling your state or local health department or a medical provider.

At this time, the CDC recommends that clinicians prioritize testing hospitalized patients and symptomatic healthcare workers. Second-level priority includes patients in long-term care facilities with symptoms, patients 65 years of age and older with symptoms, patients with underlying conditions with symptoms and first responders with symptoms.

Not sure if you should get tested? The CDC website features a "self-checker" to help you make decisions about seeking medical care. The feature is not intended for the diagnosis or treatment of COVID-19 and is intended only for people in the U.S.

Contributing: Ryan Miller, Jesse Yomtov and Grace Hauckare bothersome but tolerable and 3 is reserved for severe symptoms that are hard to tolerate and interfere with daily activity (Table [1](#Tab1){ref-type="table"}). TNSS is calculated by adding the score for each of the symptoms to a total out of 12. Another method, the Visual Analogue Scale (VAS), is a 10 cm scale that ranges from "no symptoms" to "worst symptoms ever" for each of the nasal symptoms \[[@CR35]\]. Both methods are subjective, and thus depend on the tolerance and perceptions of the participant, which may cause variability in the data \[[@CR36]\].Table 1**Total Nasal Symptom Scores (TNSS) Each symptom (sneezing, congestion, itching, and rhinorrhea) is graded from 0-3 by the participants during the screening and NAC visitsScoreSymptoms**0=NoneNo symptoms evident1=MildSymptom present but easily tolerated2=ModerateDefinite awareness of symptom; bothersome but tolerable3=SevereSymptom hard


collection, through the pilot studies described here. This process allows multi-centre clinical trials to occur with more consistency and reliability.

Methods {#Sec2}
=======

This study was conducted following approval from the Research Ethics Board of each site, and written informed consent was obtained from each participant.

Inclusion and exclusion criteria {#Sec3}
--------------------------------

Inclusion criteria included a history of developing AR symptoms on exposure to an inhaled allergen to which the participant had a positive skin prick test (≥3 mm wheal compared to the negative control).

Participants were excluded if they had a history of a clinically significant chronic disease deemed limiting to tudy participation; a positive history for HIV, TB, HBV, or HCV; any nasal structural abnormalities or polyps; current signs/symptoms of active perennial rhinitis or seasonal AR; a history of frequent nasal bleeding or nasalTNSS were achieved. If the participant reached the highest concentration of 1:2 without qualifying they were excluded.

At the NAC visit the qualifying allergen concentration from the screening visit was used as the single concentration for nasal challenge. PNIF and TNSS were recorded by the participants before the challenge, then at 15 min, 30 min, 1 hour, and then hourly for 12 hours following the nasal challenge.

The CAC study conducted at Queen's University used a cumulative concentration of all the doses administered during the screening visit and this new allergen concentration was used at the NAC visit. For example, a participant who qualified at 1:128 at screening would receive a cumulative concentration of 1:98 (by adding the individual allergen concentrations of 1:2048, 1:512, and 1:128). The CAC also had a further modification in


(DPR) experienced a peak at 15 min. following NAC while those that experienced a protracted EPR (pEPR) had a gradual rise in TNSS up to 1 hr. This suggests that the 1hr time point ensures that the maximal amount of cytokines are secreted by this time point in all participants and therefore is the best time point for sampling nasal cytokines. While EPR experienced a drop in TNSS following the peak, pEPR maintained their symptoms level before declining, DPR experienced a drop in TNSS following the peak but did rise again later in the study. Statistical analysis was not possible since participant populations experiencing certain phases were too small to compare. Nevertheless, differences in scores over the 12 hour period were distinct from one participant population to thefall or TNSS alone as a measure of a positive challenge appears insufficient, since participants that met criteria for one of the measures did not necessarily meet the other. Both a minimum TNSS and a PNIF fall are needed to increase the chances of repeating the same scores in the NAC visit. The "TNSS + PNIF" group experienced significantly higher symptoms than either groups that qualified on only one criterion, similar to what was observed during screening.

Additionally, the "PNIF only" group did not manage to maintain the PNIF reduction, while the other groups did. The "TNSS + PNIF" group did not maintain their TNSS score which might be due to a short fall of the QAC protocol which uses a threshold dose allergen challenge protocol (as compared to the follow-up CAC study).


Co., Sept 1894)
 1. Gavotte et Musette. 2. Lointain passé. 3. Scherzino.
Op. 12
Op. 13
Op. 14: Pensées Fugitives, for piano.
 1. En Valsant. 2. In Memoriam 3. Mélodie Intime
Op. 15
Op. 16: Impressions. Trois Morceaux pour piano. (1895)
 1. Improvisation. 2. Veille de Départ. 3. Humoresque
Op. 17: Ballade for violin and orchestra (or violin & piano) (1900)
Op. 18: Three Romantic Pieces for cello & piano. (1896)
 1. Petite Romance 2. Arioso 3. Feux follets
Op. 19
Op. 20: Modern Suite (Suite de Ballet) for orchestra. (1896) Also ?arr. piano as 4 Morceaux?
 1. Prelude. 2. Minuetto. 3. Ballade. 4. Scherzo-Valse
Op. 21: Coronation March, for orchestra. Also arr. piano. (1896/7)
Op.22: Concertino in C minor for clarinet and orchestra. Also arr. clarinet & piano. (1897)
Op. 23
Op. 24: Fêtes Galantes. Miniature Suite forThe present invention relates generally to intermodal trains for transporting over-the-road vehicles or loads and more specifically to a lock and coupler for a ramp car for such trains.
The design of special cars to be used in a railroad system to carry containers or trucks or truck trailers has generally been modification of existing railroad stock. These systems have not been designed to accommodate for the specific loads thus, have not taken advantage of these lighter loads. The economy and operation as well as original material were not taken into account.
An integral train is a train made up of a number of subtrains called elements. Each element consists of one or two power cabs (locomotives) and a fixed number of cars. A typical example is illustrated in U.S.


instantly that this type of music will struggle to stand the test of time. I found the electronic sounds kind of cheesy and dated. It reminded me of 80s horror movie soundtracks. Ok ok… I said I’d give them a chance. Putting myself back in that time I do realize how weird it was to hear music with almost no traditional instruments. I imagine there were many people that were blown away by how unique these sounds were as it opened up a whole new music genre. I respect that, I really do. I also respect what they did.

For me though, it’s just a bit too weird and unstructured. To this day I still am not a fan of most slow tempo music and I love a greataction

to the bankruptcy court, but shortly thereafter the bankruptcy judge remanded the case to

the superior court.

Marshall's Motion for Leave to Amend

       In February 2011, the case was set on the trial readiness calendar for April 2011.

In March 2011, Marshall moved for leave to file a first amended cross-complaint adding

causes of action for conspiracy to commit fraud, negligent misrepresentation, usury,

"RICO conspiracy," cancellation of instrument, elder abuse and declaratory relief. In

part, she sought to add allegations that Bochner conspired with his agent, Rolando

DeArmas, to induce the Marshalls to execute a deed of trust on their residence as security

for his purchase loan; that DeArmas told them the legal documents they signed would not

cause their homes to be used as collateral for the Church property, and


asserted in documents such as orders, findings of fact and conclusions of law, and
judgments." ' " (Ramsden, at p. 879.) It does not address unsigned judgments or stand
for the proposition that an unsigned judgment is inadmissible hearsay that cannot be
judicially noticed. In any event, Marshall has not demonstrated she suffered prejudice
from any assumed error, which is fatal to her evidentiary challenge. (See Paterno v. State
of California (1999) 74 Cal.App.4th 68, 105.)
                                              5
personal guarantee. Marshall sought to allege that DeArmas did not provide theman unlawful detainer judgment
will have res judicata effect for subsequent claims of fraud or quiet title suits founded on
the same allegations of irregularities in a trustee's sale." [¶] . . . [¶] Finally, the 7th
cause of action for Declaratory Relief is moot. The [first amended cross-complaint]
alleges a controversy exists between the parties related to what obligations [Marshall] is
obligated to pay . . . Bochner under the Promissory Note; the interest rate under the Note
being usurious; and whether Reliable was entitled to foreclose on the Church Property.
. . . However, as stated above, the Settlement Agreement and [unlawful detainer]
Litigation answered these matters."


attorney fees, permitting the declaratory relief action

to proceed.

                                              9
       After issuing a tentative ruling, hearing argument and taking the matter under

submission, the court granted the motion. It thereafter entered judgment in Bochner's

favor. Marshall appeals from the judgment.

                                       DISCUSSION

 it was

entitled to assess the merits of Marshall's claims in view of undisputed procedural events.

(See Huff v. Wilkins (2006) 138 Cal.App.4th 732, 746 ["Leave to amend is properly

denied when the facts are undisputed and as a substantive matter no liability exists under

the plaintiff's new theory."]; Foxborough v. Van Atta (1994) 26 Cal.App.4th 217, 230

["[I]f the proposed amendment fails to state a cause of action, it is proper to deny leave to

                                             11
amend."]; Oakland Raiders v. National Football League (2005) 131 Cal.App.4th 621,

654 [court properly


and she does not otherwise meaningfully address

whether she was reasonably diligent in proposing her first amended cross-complaint or

why the trial court erred by finding otherwise.

       Marshall further argues that Bochner was not prejudiced by the proposed amended

pleading because "he knew about the defect for over five years and made no move to

raise the issue [via his motion for judgment on the pleadings] until two . . . weeks before

the trial date." The question in reviewing the trial court's order denying leave to amend,

however, is not whether Bochner timely challenged Marshall's operative pleading, but

whether Marshall exercised reasonable diligence in seeking leave to amend. (See M & F

Fishing, Inc. v. Sea-Pac Ins. Managers, Inc., supra, 202 Cal.App.4th at p. 1534; P&D

Consultants, Inc. v. Cityexpert in stock trading game and foreign exchange. This is just what certainly with, so you let it sit during this. Having a problem or getting into it’s possible to be very easy. However if you take this tip you will not have to worry about Big John’s guys knocking in your door at 4am

4. No loyalty! This can be tough one. The truth is I am a fervent FSU Seminole, should you cut me I will truthfully bleed garnet and gold. Take my word, one Friday night I attempted. But it doesn’t matter how much I really like my alma mater, it should not influence my decision to produce a sound bet. I am talking about we are talking money. Along with the before I checked FSU


two different cross-validation strategies (further details on PotentialNet training are included in Methods). In addition, we ascertain the capacity of our trained models to generalize to assays conducted outside of our institution by downloading datasets from the scholarly literature and conducting further performance comparisons. Finally, we conduct a prospective comparison of prediction accuracy of Random Forests and PotentialNet on assay data of new chemical entities recorded well after all model parameters were frozen in place.

Results
=======

The primary purpose of supervised machine learning is to train computer models to make accurate predictions about samples that have not been seen before in the learning process. In the discipline of computer vision, the ability to interpolate between training samples is often sufficient for real-world applications. Such is not the case in the hERG inh (MK499)         0.291 (0.286, 0.295)     0.451 (0.447, 0.456)      0.161    55.306
  hepatocyte Cl, dog       0.298 (0.266, 0.329)     0.459 (0.429, 0.489)      0.162    54.326
  solubility at pH7        0.331 (0.327, 0.335)     0.496 (0.493, 0.5)        0.165    49.843
  hepatocyte Cl, human     0.265 (0.252, 0.279)     0.431 (0.417, 0.444)      0.165    62.323
  CYP2D6 IC50


0.120 (0.103, 0.138)     0.192 (0.172, 0.213)      0.072    59.540
  NaV 1.5 IC50             0.137 (0.119, 0.155)     0.213 (0.192, 0.234)      0.076    55.582
  solubility in FASSIF     0.199 (0.188, 0.21)      0.286 (0.274, 0.298)      0.087    43.823
  CYP3A4 IC50              0.255 (0.236, 0.274)     0.344 (0.325, 0.364)      0.089    35.108
  PAMPA      35.231
  PXR activation           0.507 (0.48, 0.533)       0.644 (0.622, 0.664)       0.137     26.992
  microsome Cl, dog        0.542 (0.313, 0.711)      0.686 (0.506, 0.809)       0.144     26.591
  t1/2, dog                0.436 (0.336, 0.526)      0.588 (0.506, 0.659)       0.152     34.790
  CYP2C9 IC50


Stage Struck (album)

Stage Struck is the eleventh album and the third live album by Irish singer/guitarist Rory Gallagher.  Released in 1980, it documents his world tour in support of his 1979 album Top Priority.  Accordingly, it features many songs from that album, but it also includes songs from his previous albums. The album sees Gallagher taking a faster-paced, more hard rock sound than on his previous blues-dominated live albums. Originally released with eight tracks, Stage Struck was augmented with two bonus tracks ("Bad Penny" and "Key Chain") when reissued in 1999, four years after Gallagher's death, by his younger brother and manager, Dónal Gallagher.

Reception
In 2005, Stage Struck was ranked number 419 in Rock Hard magazine's book of The 500 Greatest Rock & Metal Albums of AllSigned

Boston and New York: Houghton Mifflin, 2007. Alan Lee. 1st Edition, Hobbits, Lord of the Rings, Hard Cover. 8vo - over 7¾" - 9¾" tall. The Children of Hurin by J.R.R. Tolkien, published April 2007 by Houghton Mifflin. Signed by the editor and illustrator, Christopher Tolkien and Alan Lee, to a special bookplate, featuring Lee's motif of the Helm of Hador, attached to the Half Title page. "The Children of Hurin, The first standalone tale of Middle-earth since 1977, and the first complete version of one of J.R.R. Tolkien's 'Great Tales', with many exclusive features:" "Drawing together J.R.R. Tolkiens original manuscripts, using many sources spaced out over decades, Christopher Tolkien has constructed a narrative without any editorial invention." "Includes a brand new red and black Map of Beleriand


of Middle-earth since 1977, and the first complete version of one of J.R.R. Tolkien's 'Great Tales'. "Drawing together J.R.R. Tolkiens original manuscripts, using many sources spaced out over decades, Christopher Tolkien has constructed a narrative without any editorial invention." "Includes a brand new red and black Map of Beleriand specially drawn by Christopher Tolkien, which appears as a fold-out sheet." "Contains eight colour paintings and twenty-five pencil sketches, specially commissioned from award-winning artist, Alan Lee." "Features an exclusive colour frontispiece painting by Alan Lee." "Includes a specially written introduction and appendix on the history and writing of the tale by Christopher Tolkien." "Printed on superior quality paper and including a silk ribbon marker." A beautiful edition, with the added significance of the signed limitation page. Don't expect tosigned and dated 5th of May 2009, by Bill Sanderson to the half title page. Features a color frontispiece of a facsimile page from J.R.R. Tolkien's original manuscript. Quarter-bound in brown with gray boards, stamped in gold foil with a unique motif of Sigurd's horse, Grani, and housed in a matching custom slipcase. Printed on superior quality paper and including a silk ribbon marker. Still sealed in original publishers shrinkwrap, photos of opened book are from another copy. Matches the earlier Deluxe Editions of The Children of Hurin, The Silmarillion, The Lord of the Rings, The Hobbit, and Tales from the Perilous Realm. Digital photo's available, inquire if interested. Other Tolkien books available, include both the UK and US editions, original cloth bindings, custom fine bindings, and Signed/Numbered/Limited


on the front boards of the book and the original publishers slipcase. The single volume has silver gilded edges, red ribbon marker bound in, and signed limitation page. Fifty original illustrations by Alan Lee thru the book. You can follow how the movies were first visualized by Lee, and carried thru by Peter Jackson, with Lee's assistance throughout the movie's production. A scarce book, again one of only 200 produced. The cloth of the book is clean and unmarked, with no wear to the edges, and the leather is unmarked, clean and bright. The Tolkien monogram is clean and bright on both book and slipcase. A minor area on the backside of the slipcase, showing some soiling, and minor marks from a cleaning attempt. The slipcase shows someminor wear to the edges, with a few frayed edges on the base and top of the case. The text block and all illustrations are clean and bright, no signatures or writing whatsoever. A beautiful, highly collectable Signed Limited Numbered Edition for the Tolkien collector. Digital photo's available, inquire if interested. Other Tolkien books available, include both the UK and US editions, original cloth bindings, custom fine bindings, and Signed/Numbered/Limited Editions.Item #1522

London: Harper Collins, 1998. Ted Nasmith. First Thus. Hard Cover. 4to - over 9¾" - 12" tall. The Silmarillion, by J.R.R. Tolkien. Published by Harper Collins in 1998, this 1st impression copy contains 20 full colour illustrations specially commissioned by artist Ted Nasmith and has a sketch of the "Halls of Manwe" or "Taniquetil" to the half


---
abstract: 'For a large class of amenable transient weighted graphs $G$, we prove that the sign clusters of the Gaussian free field on $G$ fall into a regime of *strong supercriticality*, in which two infinite sign clusters dominate (one for each sign), and finite sign clusters are necessarily tiny, with overwhelming probability. Examples of graphs belonging to this class include regular lattices such as ${\mathbb{Z}}^d$, for $d\geq 3$, but also more intricate geometries, such as Cayley graphs of suitably growing (finitely generated) non-Abelian groups, and cases in which random walks exhibit anomalous diffusive behavior, for instance various fractal graphs. As a consequence, we also show that the vacant set of random interlacements on these objects, introduced by Sznitman in *Ann. Math., 171(3):2039–2087, 2010*, and which is intimately linked }
    args += rebase_path(sources, root_build_dir)
  }
}

manifest("select_to_speak_manifest") {
  output_file = "$select_to_speak_out_dir/manifest.json"
}

manifest("select_to_speak_guest_manifest") {
  output_file = "$select_to_speak_out_dir/manifest_guest.json"
  is_guest_manifest = true
}


---
abstract: 'The projective normality of smooth, linearly normal surfaces of degree 9 in ${{\Bbb P}^{N}}$ is studied. All non projectively normal surfaces which are not scrolls over a curve are classified. Results on the projective normality of surface scrolls are also given.'
address:
- 'Department of Mathematics - Eastern Michigan University - Ypsilanti MI- U.S.A.48197'
- 'Department of Mathematics- KTH - Royal Institute of Technology - S 100 44 Stockholm - SWEDEN'
author:
- 'Gian Mario Besana$^*$'
- 'Sandra Di Rocco$^{**}$'
title: On the Projective Normality of Smooth Surfaces of Degree Nine
---

\[section\] \[theo\][Lemma]{} \[theo\][Corollary]{} \[theo\][Proposition]{} \[theo\][Claim]{} \[theo\][Remark]{}

[^1]

introduction
============

Smooth projective varieties of small degree have been classified over the years and thoroughly studied, e.g. [@Io1], [@Io2], [@ok2], [@ok8], [@Ale], [@ADS]. A variety $X~\subset~{{\Bbb P}^{n}}$ is [*projectively normal*]{} if the maps $H^0({{\Bbb P}^{n}},{{\cal O}_{{\Bbb P}^{n}}({k})}) \to H^0(X, {{\cala base for $H^0(E, {{\cal O}_{E}({3P})})$ and let $a_i=p_1^*(\alpha_i)$ and $b_i=p_2^*(\alpha_i)$ be bases for $H^0(3L_1)$ and $H^0(3L_2)$ respectively. With the above notation $\{ a_i {\otimes}b_j\}$ form a base for $H^0(q^*(L)).$

Notice that an element $a_i {\otimes}b_j$ with $i \ne j$ cannot be $\iota$-invariant. To see this assume $a_i {\otimes}b_j$ were $\iota$-invariant and let $z
\in
E$ be a point such that $\alpha_i(z) = 0$ and $\alpha_j(z) \ne 0.$ Then $(a_i {\otimes}b_j)(z,y) = (a_i {\otimes}b_j)(y,z)$ implies $\alpha_i(y)\alpha_j(z) = 0$ for every $y,$ which is impossible. Simple direct checks show that $$a_1 {\otimes}b_1, \ a_2 {\otimes}b_2, \ a_3 {\otimes}b_3, a_1 {\otimes}b_2 +
\
a_2 {\otimes}b_1, a_1 {\otimes}b_3 + \ a_3 {\otimes}b_1, a_2 {\otimes}b_3 + \ a_3 {\otimes}b_2$$ form a basis for $H^0(q^*L)^{\iota}$ and that $$t_1= a_1 {\otimes}b_2,t_2=
a_1 {\otimes}b_3,t_3= a_2
{\otimes}b_3$$ span a $3$-dimensional subspace $V$ such


genus of projective varieties. , 8(4):35–68, 1981.

Y. Homma. Projective normality and the defining equations of ample invertible sheaves on elliptic ruled surfaces with $e \ge 0$. , (31):61–73, 1980.

Y. Homma. Projective normality and the defining equations of an elliptic ruled surface with negative invariant. , (33):17–26, 1982.

Paltin Ionescu. Embedded projective varieties of small invariants. In [*Proceedings of the Week of Algebraic Geometry Bucharest 1982*]{}, number 1056 in Lecture Notes in Mathematics, pages 142–186. Springer Verlag, 1984.

Paltin Ionescu. Embedded projective varieties of small invariants [II]{}. , (31):539–544, 1986.

Paltin Ionescu. Embedded projective varieties of small invariants [III]{}. In [*Algebraic Geometry L’Aquila 1988*]{}, number 1417 in Lecture Notes in Mathematics, pages 138–154. Springer Verlag, 1990.

Elvira Laura Livorni. On the existence of some surfaces. In [*Algebraic Geometry L’Aquila 1988*]{}, number 1417 in Lecture Notes inI may tell you we expect some tough yarns of you;
our taste has been tickled by Miles, who has some miraculous--why, where
is Miles?"

Miles had vanished.

"What made him go, I wonder?" asked Alice, with the slightest
perceptible annoyance. Dick did not perceive it, but he thought the
question odd. To disappear seemed to him the only thing a stranger, who
was also a gentleman, could have done; he was scarcely impartial on the
point, however.

Alice took up the theme which her father had dropped.

"Oh, Mr. Miles has some wonderful stories," said she; "he has had some
tremendous adventures."

"The deuce he has!" thought Dick, but he only said: "You should take
travellers' tales with a grain of salt."

"Thanks," Alice instantly retorted; "I shall remember that when you tell
yours."

They laughed over the retort. All three began to


there would be a moon. When is there a moon, Mr.
Miles?"

No answer but a deep breath, that was half a groan Alice thought.
Perhaps she was mistaken. She could not see his face, unless she moved
away from him, he was so tall. She repeated the question:

"I want to know when there will be a moon. It would be so delicious now,
if it shot up right over there, to be reflected right down there--but
why don't you speak, Mr. Miles?"

Still no answer. She drew back a step. He was standing like a monument,
tall and rigid, with his hands clasped tightly in front of him and his
face turned slightly upward. He seemed unconscious of her presence at
his side. Something in his motionless attitude, and the ghastly pallor
of his face in the starlight,been in England a day or two instead of a month or two, and you
had set foot in Sussex only; instead of masquerading as a fisherman you
wore your own sailor's clothes, in which you swam ashore from your
ship."

"Well guessed!" said Miles ironically.

"A cleverer thing was never done," Dick went on, his tone, for the
moment, not wholly free from a trace of admiration. "Well, apart from
that first set of lies, your first action in England was a good one.
That is one claim on leniency. The account you have given me of it is
quite true, for I heard the same thing from one whose lips, at least,
are true!"

These last words forced their way out without his knowledge until he
heard them.

"Ah!" said Miles.

An involuntary subdual of both voices might have been


her.

The next moment she heard the key turn in his door.

He sat down on the edge of the bed, lit his pipe, and withdrew the
cuttings from the indiarubber band. There was not much to read, after
all; only three paragraphs, of which two were telegraphic, and
consequently brief. In no case was either name or date of the newspaper
attached; but in the short paragraphs Dick seemed to recognise the type
of the "Australasian," while there was internal evidence that the longer
one emanated from a Queensland organ. After glancing rapidly at all
three, he arranged them in an order that proved to be chronologically
correct.

The first paragraph (telegraphic: headed "Brisbane, Friday,") stated
that, on the afternoon of the day before, the branch of the Australian
Joint-Stock Bank at Mount Clarence had been entered by two bushrangers,
onedo her no harm), the father's heart became more and
more distressed as each new symptom was made plain to him. He was both
worried and perplexed. He called in a local doctor. That move made her
ill-health no better, and her ill-temper worse. What, then, could the
father do? Always loving and indulgent--never intimate--with his child,
it had been his practice, when serious matters arose, to employ the
ambassador always at hand; thus there had never, during all the years,
been a word of contention between father and daughter; and to this
practice the father resorted now.

Late one afternoon they were all three sitting in the garden, when Alice
rose, without breaking her long silence, and slowly walked towards the
house. The Colonel followed her with his eyes; he held a glowing
cigarette between his fingers; the distance


apparently of contrary
character: for while the perusal of one gratified him so intensely that
he could not help handing it round for them all to see, the mere sight
of the other was sufficient to make him thrust the unopened envelope
hurriedly into his pocket.

The first letter was indeed a matter for congratulation, for it was the
most completely satisfactory, though not the first, of several similar
communications which Dick had received since his return from Australia.
It was a short note from the editor of the "Illustrated British
Monthly," accepting (for immediate use: a great point) a set of sketches
entitled "Home from Australia," which set forth the humours and trials
of a long sea voyage, and were, in fact, simply a finished reproduction
of those sketches that had delighted the passengers on board the Hesper.
But itside of life to me. I found it was
the best side. I grew--well, call it happy. Then I looked back and
loathed the old days. I began to map out a better life for myself. I was
a new man, starting afresh. I thanked God for my escape, for it seemed
like His act."

"If the fellow isn't in earnest," thought Dick, "this is the worst
blasphemy I ever heard. I half think he means what he says, poor
wretch."

"It was you that blotted out that new existence--just as it opened out
before me! It was you that drove me from my haven! It was you that
turned me adrift in a city full of foes! So much for your side of the
balance between us!"

Dick was half-carried away by the man's rough eloquence, and the note


scoring off them both at once.
And Philip Robson had contracted a pretty strong grudge against both
these men since morning.

Meanwhile Miles remained subdued and pensive, furtively attentive, but
extremely humble, towards Miss Bristo, and talkative to one person
only--Mrs. Parish. He was indeed, as he said, no fool. He was full of
cunning and coolness, foresight and resource. He was biding his
time--but for what?

                                 XXIII

                       THE EFFECT OF A PHOTOGRAPH

Laurence Pinckney was a hopeless sportsman. When he realiseda snake-story they were listening to now;
and the face of the narrator, thrust forward close to the sputtering
wick, was the smooth, heavy, flexible face of the man whom Pinckney had
photographed unawares on the road.

Pinckney went softly back to the parlour, whistling a low note of
surprise.

"No wonder I didn't recognise the voice! That voice is put on. The surly
growl he gave me this morning in his natural tone. He's making up to the
natives; or else the fellow's less of a brute when he's drunk, and if
that's so, some philanthropist ought to keep him drunk for his natural
life. The terms might be mutual. 'I keep you in drink, in return for
which you conduct yourself like a Christian,--though an intoxicated one,
to me and all men.'"

"Who is that customer?" Pinckney asked of


hated her! With his lips he cringed to her, in his heart he ground
her to powder; but if he was not in the position to bully her to-day, he
had lost few opportunities when he was; and he was at least forearmed
against her.

He affected a bluff kindliness of manner that would not have deceived
her had Mrs. Ryan been a little more composed.

"Look here, missis, you and me, we've been bound up in a ticklish job
together. I don't say as I've always done by you as I should, but there
is allowances to be made for a man that carries, as they say, his life
in his hand, and that's staked his life on this here job. I don't say,
either, as we're both on the exact same tack, but one thing's certain;
wego somewhere else for it: I have
none."

"What!" cried Pound, savagely, "is it all gone? All that you landed
with? Never! You have never got through all that!"

"'All that' is under a gum-tree somewhere in Queensland, unless some one
has found it lately. I told you so before, didn't I? How could I clear
out with the gold? How could I risk going back for it when once I got
away? All I brought with me was what never left my body: the notes and
some gold. It didn't come to much; the last of it went long since."

"Then how have you lived--what on?"

"My wits."

Jem Pound was in a towering passion.

"If I believed you," he hissed out, among his oaths, "I'd make a clean
breast of everything--every blessed job--though I swung for it! No; I'd
swing


headlong up the hill.

On the crest of the second hill, above the beck and the bridge, he
stopped to look round. The people on the steps were moving. Their number
had increased. He could distinguish a servant-maid holding her apron to
her eyes. They were moving slowly; they were carrying something into the
house--something in a white covering that hung heavily as a cerement in
the heavy air.

                                 XXVII

                            THE FATAL TRESS

Was she dead?

Theimport. Then he knelt
down and leant over the prostrate Ryan, with the confident air of a
lucky man on the point of crowning a very pyramid of good fortune.

Slowly and daintily he unfastened the studs in Ryan's shirt; he was
playing with blood now, and must avoid unnecessary stains. He would just
take what he wanted--take it cleverly, without leaving a trace
behind--and satisfy himself that it was what he wanted, more or less.
Then he would fire one chamber of Ryan's revolver, and make off. But
first--those notes! The chest was already bathed in blood; but Pound saw
at once the object of his search, the cause of his deed, and his black
heart leapt within him.

Well, the little oiled-silk bag was small--unexpectedly
small--incredibly small; but then there were bank notes for enormous
sums; and one bank-note,


a man struck down--dying, as it seemed. How could one think that on
the brink of the grave a man should ask for news from another's sick
bed? Edmonstone was puzzled by the little word, and showed it.

"You know what I mean?" exclaimed Ryan, with weary impatience. "Is
she--is she--dead?"

"God forbid!" said Dick. "She is ill--she is insensible still. But man,
man, what about you? What have you done?"

"What have I done?" cried Ryan, hoarsely. "I have come to bring help to
her--and--I have failed her! I can get no further!"

His voice rose to a wail of impotent anguish. His face was livid and
quivering. He fell back exhausted. Dick attempted to staunch the blood
that still trickled from the wound in the chest. But what could he do?
He was powerless. In his helplessness heher, and then shown Ned
his drunken wife at their second meeting; whom she had to thank for all
her misery: the fiend, Jem Pound.

It was true that Ned had treated her heartlessly; but, believing what he
believed of her, could she blame him? She blamed him for listening to
the first whisper against her, from the lips of a monster; but his fault
ended there. He had never heard her in her own defence. He had not so
much as seen her alone. There lay the root of it all: she had been
allowed no chance of explaining, of throwing herself on his compassion.

But now she was going to put an end to all this. She was going to him at
once, and alone. She was going to tell him all: how she had waited
patiently


to say, until an involuntary murmur
escaped him.

"Poor Miles!"

The girl's answer was a low sob.

Then here was the truth at last. The innocence and purity of the young
English girl had awed and appalled that bold, desperate, unscrupulous
man at the last moment. On the brink of the worst of all his crimes his
nerve had failed him, or, to do him better justice, his heart had
smitten him. Yes, it must have been this, for the poor fellow loved her
well. His last thought was of her, his last, dying effort was for her,
his life's blood ran out of him in her service!

But Alice! Had she not loved him when he spoke? Had she not given her
heart to him in the beginning? Had she not tacitly admitted as much in
this very room? Then\times 10^{34}$ [[erg s$^{-1}$]{}]{}, in the full-band ($0.3 - 8$ keV) while on average the complete sample of clusters had the lowest upper limit, $6.46 \times 10^{33}$ [[erg s$^{-1}$]{}]{} in the hard-band ($2 - 8$ keV). We determined average luminosities of the young and old star cluster populations and compared the results to those from the Milky Way. We conclude that deeper X-ray data is required to identify faint sources with a stacking analysis.'
author:
- 'N. Vulic, P. Barmby, and S. C. Gallagher'
title: 'Stacking Star Clusters in M51: Searching for Faint X-Ray Binaries'
---

Introduction {#sec:intro}
============

An X-ray binary (XRB) consists of a compact object such as a neutron star (NS) or black hole (BH), that accretes matter from a donor star, which is generally a main sequence (MS) or red giant star.


\sim 10^{35}$ [[erg s$^{-1}$]{}]{} [@zhang09-11]. In general, since most elliptical galaxies are devoid of gas and dust (and therefore lack star formation), only LMXBs are formed and so it is straightforward to identify them. The younger stellar population of spiral galaxies allows the formation of HMXBs, which have been identified separately from the diffuse emission in these galaxies via bright optical counterparts. Conversely, LMXBs have been more difficult to identify in spiral galaxies (because of faint optical counterparts) and therefore comprise an important element of future research.

M51 has been studied numerous times in X-rays by different groups, with the most recent population analysis from [[*Chandra*]{}]{} observations by @terashima02-04. They focused on the bright-end of the X-ray luminosity function (XLF) of M51, investigating ultraluminous XRBs, and implied that these were likelyand energy bands. In most cases, except the soft and full-band old clusters, the background-subtracted luminosities in the source apertures were negative. This means that the background level is actually higher than that of the source. Inspection of the images shows that many contain point sources distributed randomly outside the source aperture. This could be consistent with ejections of XRBs from star clusters in M51. From the diameter of our image ($\sim$ 425 pc) it is possible that the point sources we see have been ejected from clusters up to $\sim$ 200 pc, similar to results from other groups. This could contribute to the lack of both bright and faint XRBs within 1.5 ($\sim$ 60 pc) of clusters.

In order to be certain that our results were not biased by


have on producing a source signal. No significant changes were observed as we retrieved upper limits for all stacked images.

All the methods used above in stacking star clusters overlook the fact that only a small percentage of clusters may have faint XRBs. This would systematically average out any signal that could be detected as star clusters with no XRBs are stacked. In an effort to address this issue, we have used the findings mentioned in section \[sec:intro\] that state bright, compact, and massive clusters are known to be more likely to host XRBs. Using V magnitudes and effective radii of M51 clusters from , we stacked the brightest and most compact (assumed small R$_{eff}$) $10$% of clusters. This was done for the complete cluster sample as well asthe YCs in the MW with a catalogue of HMXBs (within 60 pc), we found the total X-ray luminosity of $20$ YC-HMXBs to be $\sim 2.7 \times 10^{37}$ [[erg s$^{-1}$]{}]{}. For the MW, the YC population is not complete past a few kiloparsecs (kpc) due to interstellar extinction. @dias07-02\[2012 edition\] have confirmed $\approx$ 2100 YCs in the MW, meaning that the average X-ray luminosity we would expect from young clusters would be $\sim 1.3 \times 10^{34}$ [[erg s$^{-1}$]{}]{}. This value is of course a crude approximation since we observe X-ray point sources further away ($\sim$ 8 kpc; @grimm-03) than we do YCs. Of approximately 10 (33%) HMXBs matched to YCs neither the HMXB or cluster had distance information and therefore were excluded. From Figures \[fig:m51optical\] and \[fig:sccc\] we


metal-poor and the YCs metal-rich.

These calculations suffer from uncertainty due to the transient nature of XRBs, meaning that it is possible observations were made when some of the brightest XRBs were in a quiescent state. This would skew the number of bright XRBs and ultimately produce lower average X-ray luminosities. A partial solution to this problem would be to stack multiple observations (e.g., as @sivakoff06-08 did for NGC 4697) of M51 in the hope that any transient behaviour would be averaged out. Our predictions above for GCs in M51 indicate we should observe both more (quiescent) bright and faint LMXBs coincident with star clusters. This will allow us to perform a statistically more meaningful analysis. In addition, the incompleteness of the YC catalogue in the MW allows forOur source aperture of radius 1.5$\arcsec$ covers a range of $\sim$ 120 pc from a cluster core. Knowing that most star clusters have cores of only a few pc in size, with GCs being slightly larger, an X-ray point source located within the cluster should appear directly in the centre of an image. It is evident that most of the point sources appear outside the background apertures at distances $>$ 200 pc from the cluster cores. We cannot rule out the possibility that these point sources are XRBs that were in the past located in a star cluster. M51’s YCs may have experienced ejections as compact objects were created, however, we have no evidence for this.

Summary & Conclusions
=====================

We have presented an X-ray analysis of the star clusters in


in the full, hard, and soft energy bands resulted in non-detections throughout. The largest upper limit (1.3$\sigma$) was found to be $9.23 \times 10^{34}$ [[erg s$^{-1}$]{}]{} for the average GC in the full-band while the lowest upper limit was $6.46 \times 10^{33}$ [[erg s$^{-1}$]{}]{} for all clusters in the hard-band. The latter limit indicates that any source detections would have to consist of faint XRBs. The former limit would require that GCs have the largest luminosities in comparison with other cluster types. However, this was biased by the small sample size of GCs.

We implemented a number of methods in order to reduce the background level to identify any source signal that was present. This included removing bright HII regions and all point sources that were present in the background region.In addition, we stacked clusters that were brightest and most compact since they are more likely to host XRBs. This prevented any possible signal from being averaged out by stacking clusters with no X-ray emission. These methods all resulted in non-detections.

The total X-ray luminosities of young and old clusters in M51 are $\approx 2 \times 10^{39}$ [[erg s$^{-1}$]{}]{} and $\approx 10^{37}$ [[erg s$^{-1}$]{}]{} respectively. Comparing this to clusters in the MW, there should be a population of undetected transient and faint XRBs in M51’s GC population. In contrast, M51’s YC population has more X-ray emission than that of the MW’s due to its higher SFR. Average X-ray luminosities of young and old clusters in M51 were $\approx 10^{36}$ [[erg s$^{-1}$]{}]{} and $\approx 5 \times 10^{35}$ [[erg s$^{-1}$]{}]{} respectively. From inspection of the


comments that improved the manuscript. Support for this work was provided by Discovery Grants from the Natural Sciences and Engineering Research Council of Canada and by Ontario Early Researcher Awards. We acknowledge the following archives: the Hubble Legacy Archive ([hla.stsci.edu](hla.stsci.edu)), Chandra Data Archive ([cda.harvard.edu/chaser](cda.harvard.edu/chaser)), and 2MASS ([ipac.caltech.edu/2mass](ipac.caltech.edu/2mass)).\
*Facilities:* HST (ACS), CXO (ACIS), 2MASS

[77]{} natexlab\#1[\#1]{}

, A. A., [Ackermann]{}, M., [Ajello]{}, M., [et al.]{} 2010, , 524, A75

, V., [Zezas]{}, A., [Hatzidimitriou]{}, D., & [McDowell]{}, J. C. 2009, , 697, 1695

, K., [Kalogera]{}, V., & [Bulik]{}, T. 2002, , 572, 407

, K., [Kalogera]{}, V., [Rasio]{}, F. A., [et al.]{} 2008, , 174, 223

, [Á]{}. & [Gilfanov]{}, M. 2010, , 512, A16

, H. & [Hoyle]{}, F. 1944, , 104, 273

, W. N., [Alexander]{}, D. M., [Hornschemeier]{}, A. E., [et al.]{} 2001, , 122, 2810

, W. N., [Hornschemeier]{}, A. E., [Alexander]{}, D. M., [et al.]{} 2001,make up the DCS World War II, the Normandy 1944 map, the warbirds, and the World War II Assets Pack. We’d like to update you on each of these:

DCS: Normandy 1944 Map

Since the map’s release, there have been several improvements like new period objects (windmills, water towers, farm houses, etc.), better beach lines, corrected mesh errors, cleaned up textures, and more detail in the England portion of the map. Currently, Urga Media (the developer) is occupied with their Syria map. However, once the Syria map is complete, we will discuss with them further improvements to the Normandy map like use of speedtrees.

Warbirds

In addition to completing the final touches to the Spitfire (fuel tanks and bombs), our other primary focus has been the P-47D. More so than any other


into dust mite group and multiple group; Based genders, treated patients were divided into male and female group. We compared the effective rate (ER)and decreasing percent of TMS (Dp-TMS) between control and treatment group, and also different groups in treatment group. The ER and Dp-TMS of treatment group is significantly higher than control group, (P < 0.01). The ER of SLIT and comprehensive group respectively is 72.73% and 76.47%without significant difference (P > 0.05). The ER and Dp-TMS of dust mite group and multiple group respectively is 61. 54%, 94. 46%,66. 67%, 71.25% without significant difference (P > 0.05). The ER and Dp-TMS of male and female respectively are 58.33%, 66.67%, 83.33%, 97.04% with significant difference (P > 0.05), while the Dp-TMS is not (P > 0.05). Thestring and disposing of the original
two. This means "a" \+ "b" is actually a horrible way to build up a string if
you have to do lots of little additions, so most languages have some other
method of making a string of strings/chars (StringBuilder in Java and C#,
strings.Builder in Go, etc).

~~~
mankeysee
Why are strings made immutable by default in some langs (I have seen this
mainly in java and python)? Nothing fundamentally requires strings to be so.
Has some analysis been done indicating most string operations in software
would benefit by immutable form rather than non-immutable form?

~~~
ChrisSD
At least in Python, string objects are widely used as keys to dictionaries or
as options in functions. For speed and efficiency these small strings are
"interned" so that there is only ever one instance of the same string.

Also for


by using the path integral formalism and by introducing a Chern-Simons gauge field [@LF91; @KZ92].

Direct experimental evidences for the existence of Composite Fermions have been found by investigating the magneto-transport in spatially modulated quantum Hall systems. The experimentally detected resistance oscillations have been interpreted by constructing certain trajectories of quasi particles that were commensurable with the spatial modulation of the two dimensional electronic system [@W97; @Setal99; @WWP99; @ZG99].

Originally, the Composite Fermion description has been developed for fully spin-polarized quantum Hall states. There are, however, experiments in the region of low magnetic field which indicate that FQHE-ground states can be spin unpolarized [@Eetal89; @Eetal90]. Recently, the spin polarization of FQHE-ground states have been measured by radiative recombination of electrons in the inversion layer of high-electron mobility GaAs/AlGaAs-heterostructures with holesfrequency $\omega_{\rm CF}=e|B_{\rm
  eff}|/m_{\rm CF}(B)$. In mean field approximation, $m_{\rm CF}$ would be equal to $m^*$. However, taking into account the interaction between the particles in higher order, the CF mass is renormalized, thus introducing a dependence on the magnetic field [@HLR93]. If the effective filling factor $p$ of the CF is $$p=\frac{\rho\phi_0}{B_{\rm eff}}\,,$$ the filling factor $\nu$ of the original electrons corresponds to the integer filling of $|p|$ Composite Fermion Landau levels $$\label{eq:cfllfillings}
  \nu=\frac{p}{1+2mp}\,.$$ For $m=1$ (compensation of the external magnetic field at half filling) one obtains for $p=1, 2, 3 \ldots$ the sequences $\nu=1/3, 2/5, 3/7, \ldots$ and for $p=-1,-2,-3, \ldots$ the sequences $\nu=1, 2/3, 3/5, \ldots$ which are consistent with the filling factors at which the FQHE is observed.

Using the gauge argument originally


Through his expertise, he will be able to bring the operations of the business to profitability within its first six months of operations.## 1.5 Sales Forecasts Management expects a strong rate of growth at the start of operations. Below are the expected financials for the first three years.child I ever saw in my life. This child is an abomination to mankind, nature, and humanity. the entire family should be burned at the stake.

My god, I saw a child on youtube with Barbara walters named "jazz" she was 11, that was the ugliest child I ever saw in my life. This child is an abomination to mankind, nature, and humanity. the entire family should be burned at the stake.

“Today a young man on acid realized that all matter is merely energy condensed to a slow vibration, that we are all one consciousness experiencing itself subjectively, there is no such thing as death, life is only a dream, and we are the imagination of ourselves.” – Bill Hicks

I have seen the documentary about Jazz and I don't


has been around for decades. It's fact-based science, it's truth. He was found in 1903, and it's only now that they could crack the code of his genome. My own DNA chart says that I'm 4% British Isles, which is not far from the time this gentleman lived. He's quite handsome, and there's a bit of a twinkle in those blue eyes. What's not to love?

"He who learns must suffer. And even in our sleep pain that cannot forget falls drop by drop upon the heart, and in our own despair, against our will, comes wisdom to us by the awful grace of God." - Aeschylus

"He who learns must suffer. And even in our sleep pain that cannot forget falls drop by drop upon the heart, and inthey were born.

Close to tears at a press conference, Mr Tait said he felt "distraught, confused and angry". He said: "I want answers so bad. It's going to affect us one way or the other, I know that. It's going to be a long journey."

He said the people who raised him "would always be (his) mom and dad, regardless" but he "got another brother, another mom and dad".

David Tait Sr said the families would be brought closer together by the new information. "We agreed we are going to be one family."

Mrs Tait said that all the parents involved would "like to continue treating them as their own sons".

'Criminal'

In November, local government officials said two other men at the same hospital were also switched at birth in the same


If I were a Facebook algorithm trying to determine James Gunn’s main interests based on his social media output, I would conclude it was child molestation and rape instead of filmmaking.

Another thing is the buddy that sent him the video (which apparently featured a bunch of girls singing the Divinyls song “I Touch Myself), Huston Huddleston, was convicted of possessing child porn. So yeah, hundreds (maybe thousands) of child molestation “jokes”, one of which included an exchange with this convicted-of-having-child porn buddy. Who knows what other shit Gunn had to say that wasn’t screen captured prior to his twitter purge.

Then there was the NAMBLA jokes he exchanged with Lloyd Kaufman, his “men-tor” and the co-founder of Troma Studios (you know, Toxic Avenger and shit). There’s plenty to suggest        SN heat inact.       0/5             0/5        0/5   0/5

SN =  Supernatant.

Finally, susceptible LNCaP cells were exposed to PBMC supernatants taken at 7 days post infection to determine whether the newly produced virus particles are themselves infectious. XMRV could be detected by diagnostic PCR in DNA isolated from LNCaP cells a week after exposure to supernatants from XMRV-infected PBMC from 2/5 CFS patients and 4/5 healthy donors ([Table 2](#pone-0015632-t002){ref-type="table"} and [Fig. 4B](#pone-0015632-g004){ref-type="fig"}). Supernatants from none of the PBMC cultures that were initially incubated with heat inactivated 22Rv1 supernatants were able to infect LNCaP cells. The integrity of


the isolated LNCaP cell DNA was also confirmed by GAPDH amplification and the absence of XMRV plasmid DNA and mouse genomic DNA was demonstrated by PCR (data not shown). Furthermore, RT activity was detected in the supernatant from 5 of the 6 LNCaP cell cultures that tested positive for XMRV infection by PCR ([Table 2](#pone-0015632-t002){ref-type="table"}). In summary, these results demonstrate that cells present in human PBMC cultures can be productively infected by XMRV and release infectious virus particles.

Discussion {#s3}
==========

CFS/ME is a multifaceted illness with an unknown etiology and a diagnosis based on the careful exclusion of other conditions and diseases with similar symptoms including HIV infection and multiple sclerosis [@pone.0015632-Prins1], [@pone.0015632-Reeves1]. Recently, the novel human retrovirus XMRV was reported to be detectable in the lymphocytes of two-thirds ofa positive XMRV signal for contamination with murine genomic DNA or with plasmids containing the VP62 molecular clone. Indeed, this was done for all intentionally infected PBMC and LNCaP cultures and PBMC/LNCaP co-cultures.

Although we did not ourselves investigate the phenotype of the blood cells being infected with XMRV, Lombardi *et al.* have reported the infection of T- and B-lymphocytes [@pone.0015632-Lombardi1]. Infected blood cells release only very low levels of virus, barely detectable with the highly sensitive RT assay we used, whereas in contrast the supernatants of infected LNCaP cells generally contained levels of RT activity higher by 3 - 4 orders of magnitude. Nevertheless, one week after infection, the supernatants from over half of the PMBC cultures contained sufficient virus to infect LNCaP cells. The relatively poor growth


think the show has told really moving stories about both characters and come up with plenty of jokes for them that aren't rooted in race or sexuality. And there's certainly truth to the idea (advanced in both "Much Apu" and "Burns Cage") that the show gently mocks everyone, no matter who they are.

But I also can't argue too much with those who feel both characters are regressive stereotypes who constantly tie The Simpsons to a past worth moving beyond. It's weird to still have the most famous Indian character in US pop culture come packaged with the stereotypical accent, and Smithers's sexuality long ago stopped making any sort of sense.

There's still something fascinating — and maybe even heartening — about the series struggling with its origins. "The Burns(knownRoute => knownRoute.dist < route.dist + edge.dist)
    maybeBetterRoute map (knownRoute =>
      Pair(edge.to, Some(knownroute)
    ) getOrElse (
      Pair(edge.to, Some(edge :: route))
    )
  }
}

You calculate the fromHere each time, which is an O(n) calculation, I think:
val fromHere = edges.filter(e => e.from == node)

It may be better to build a Map[Node[T], List[Edge[T]]] before the recursion, which is also a fairly cheap operation:
val edgesBySource = edges groupBy (_.from)

then: val fromHere = edgesBySource.get(node).flatten. I assume this would pay off soon for non-tiny graphs.


" " << cards[3] << " " << seed[1] << " " << cards[7] <<std::endl;

    std::cout << "Your credits after this bet:" << fish - bet <<std::endl;

    return 0;
}

A:

You can do a loop that stops if the user wants to or fish is less than 0 by making a while loop that depends on some boolean playing that is initially true. So if one of the two events happen, set playing to be false and the loop stops:
int main() {
    //variables

    bool playing = true;
    while (playing) {
        int fish = 100;

        //poker game

           std::cout << cards[distribution(engine)] << '\n';
    }
}

some important things from here:
std::random_device rd;
std::mt19937_64 engine(rd());

is done only once (never in a loop). It is for initializing your pseudo random generator engine.

std::uniform_int_distribution<int> distribution(0, 8);

adds a distribution. Note that, because your int cards[9] has 9 elements, the range has to go from 0 to 8 as arrays start at 0and end at their size - 1, as you might probably already know. :)
Running this you can see it randomly prints out the card numbers from 2 to 10:
2
10
7
9
2
4
9
10
8
9
8
6
8
2
10

These are your helping points to implement further. I add some more things I noticed about your code but are not necessary to the question itself.

You should note that you should not use namespace std - you


can read here why.

Also, instead of:
char seed[4][10] = { "hearts","clubs","diamonds","spades" };

use:
std::string seed[4] = { "hearts","clubs","diamonds","spades" };

To use std::string include the <string> header.

you wrote std::cin >> name; but this doesn't work for strings with spaces, like look here:
Welcome in PokerBash! Please enter your name:
Stack Danny
Your name is Stack

To get the full name, use
std::getline(std::cin, name);

should certainly plug the “black hole” that existed before – assuming everyone stays healthy. Yes, projections are only projections and there’s certainly more health risk with this platoon than the old one, but if things go as Hahn and the front office envision, this upgrade may end up having more impact than the addition of Brett Lawrie at second base.

In summary, here's what we "got" from Hahn's whirlwind catching overhaul:

PROS

Substantial increase in OBP

Substantial improvement in pitch blocking

Likely noticeable improvement in runners caught stealing

Slight increase in SLG

CONS

Substantial downgrade in pitch framing

Much higher health/injury risk

Short-term solution

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transduced with HRK or control vectors (green: TUNEL, blue: DAPI, scale bars: 10 µM)

Bcl-2 and Bcl-xL inhibits HRK-induced cell death in GBM {#Sec4}
-------------------------------------------------------

HRK is known as a sensitizer BH3 only protein and triggers apoptosis by neutralizing the anti-apoptotic Bcl-2 and Bcl-xL proteins^[@CR15]^. However, the regulatory role of HRK in the apoptosis of cancer cells has not been studied before. To test the functional interaction between Bcl-2, Bcl-xL, and HRK in GBM cells, we first examined endogenous levels of Bcl-2 and Bcl-xL expression and observed that A172 cells expresses elevated levels of both Bcl-2 and Bcl-xL compared to LN18, U87MG, and U373 cells (Fig. [2a, b](#Fig2){ref-type="fig"}). We then generated GFP, Bcl-2 and/or Bcl-XL overexpressing GBM cells using bicistronic retroviral vectors encoding GFP. When we overexpressed HRK in Bcl-2 and/or Bcl-xL andGFP-expressing GBM cells, we observed that Bcl-2 and/or Bcl-xL overexpression inhibited HRK- induced apoptosis and led to the recovery of cell death in LN18 (Fig. [2d](#Fig2){ref-type="fig"}), U87MG (Fig. [2f, h](#Fig2){ref-type="fig"}), and U373 (Fig. [2e, g](#Fig2){ref-type="fig"}), but not in A172 cells (Fig. [2c](#Fig2){ref-type="fig"}). The overexpression of HRK in these cells did not affect the endogenous expression levels of Bcl-2 or Bcl-xL, as well as several other Bcl-2 family members, attesting that HRK overexpression does not indirectly regulate the levels of Bcl-2 family member expression (Supplementary Figure [1](#MOESM2){ref-type="media"}). These results suggest that HRK functions through regulating Bcl-2 and/or Bcl-XL activity in GBM cells.Fig. 2Bcl-2 and/or Bcl-xL overexpression inhibits HRK-induced death in GBM cells.**a**, **b** Gene expression levels of Bcl-2 and Bcl-xL in A172, LN18, U87MG, and U373 cells detected by qRT-PCR. Values are normalized to the


U373). Accordingly, cells were categorized according to their TRAIL response as sensitive (A172), mid-sensitive (U87MG and LN18) and resistant (U373) (Fig. [4a](#Fig4){ref-type="fig"}). To examine the combinational effect of HRK overexpression and TRAIL in GBM cells, we treated control (GFP-expressing) or HRK-expressing GBM cells with TRAIL. Cell viability analysis showed that while TRAIL reduced the viability of TRAIL-sensitive A172 cells, HRK did not cause an additional death, consistent with previous results. In TRAIL-resistant U373 cells, viability was significantly decreased by HRK overexpression, but it was not affected by TRAIL treatment. In contrast, HRK overexpression cooperated with TRAIL in U87MG and LN18 TRAIL mid-sensitive GBM cell lines, where HRK-overexpressing cells had better response to TRAIL treatment (Fig. [4b](#Fig4){ref-type="fig"}). For further examination, we measured TRAIL-induced caspase 3/7 activation in HRK-overexpressing GBM cells. CaspaseFasL (Supplementary Figure [6](#MOESM2){ref-type="media"}), and the mechanistic details of such cooperation prompts further studies.

Innate or acquired TRAIL resistance is a major problem in TRAIL-based therapies and combinatorial approaches that aim to overcome such resistance is a promising therapeutic approach. One of the well-known TRAIL-sensitizing secondary agents is MS-275, a histone deacetylase inhibitor^[@CR18]^. While the sensitization mechanism of MS-275 and similar agents involve the upregulation of death receptors and/or downregulation of anti-apoptotic proteins, exact mechanisms are still ill-defined. In this study, we have shown that HRK expression is responsive to MS-275 treatment and that the knockdown of HRK inhibits the TRAIL sensitizing effect of MS-275. These results suggest that HRK can be key factor for the sensitization mechanism of MS-275.

Finally, we showed that HRK expression led to slower tumor growth


has spurred a new interest in using subcarrier for data transmission and paging services in addition to the more conventional audio services. FM and TV stations are now permitted to use up to two additional audio or data channels on the main carrier of the station. Subcarriers added to FM broadcast stations include Subsidiary Communications Authorizations (SCA) while subcarriers added to a TV station's aural carrier include a Secondary Audio Program (SAP) or a non-public channel for Professional use (PRO).Q:

Why is ctx.state.user undefined after logging in user when using koa-passport

I am using koa-passport to handle the local signup/login in my react app. I am trying to set up the local authentication without the redirect, since I want to handle routing on the client side.
My Problem: When I send a request to the server after successfully authenticating and logging in a user, I don't have the ctx.state.user object I was hoping to get.
Here is my initial login:
router.post('/login/local', passport.authenticate('local-login', function(err, user, info) {
  if (err) // handle error
  else if (!user && info) // handle no user
  else {
    // handle successful login
    ctx.login(user);
  }
}));

Then, I want to access the logged in user, like so:
router.get('/profile', (ctx) => {


Former federal Liberal cabinet minister Andy Scott died in Fredericton of cancer and is being remembered as a politician with a social conscience. He was 58.

Scott represented Fredericton in the House of Commons from 1993 to 2008 and served as solicitor general under former prime minister Jean Chretien and then the minister of Indian Affairs and Northern Development in the Paul Martin government.

Many of Scott's friends and colleagues described him on Tuesday as a leader and a politician with a social conscience.

Flags on all government buildings in Fredericton will be at half-mast until sunset the day of his funeral, Minister of Canadian Heritage and Official Languages James Moore posted on Twitter.

Andy Scott, a former federal cabinet minister, died in Fredericton. He was 58.

Premier David Alward issued a statement,of metaphorical descriptions was a response to the lack of a firm theoretical background. It facilitated a preliminary classification of plant movement and a comparison of observations. Perhaps his most fruitful metaphors were those drawn from economic concepts, such as division of labour. Darwin's legacy in plant physiology is impressive, as even the most recent biophysical interpretations of climbing plants (e.g. tendril perversion) take place inside the framework he constructed.


because Vn initiates EGFR signaling in the ASP and induces a positive feedback loop that stimulates cell proliferation and survival in the stalk cells proximal to the tip cells \[[@B56-ijms-19-02074]\]. Interestingly, the mechanism of action for this feedback loop is the activation of the mitogen-activated protein kinase (MAPK) signaling pathway by both Vn/EGF and Bnl/FGF; the key difference between stalk cells and the tip cells that induces their proliferation is that when MAPK is activated by Bnl/FGF, additional transcription factors, including pointedP1 (PntP1) and escargot (Esg), are expressed as well \[[@B22-ijms-19-02074],[@B23-ijms-19-02074],[@B56-ijms-19-02074]\] ([Figure 4](#ijms-19-02074-f004){ref-type="fig"}). It has been proposed that Esg inhibits the proliferative genetic program activated by Vn/EGF-induced MAPK signaling and maintains the cell survival program, while PntP1 stimulates cell migration, together contributing to the determination of tip cell\[[@B79-ijms-19-02074]\]. Elucidating the network of interactions required for Hox-mediated control of mitosis in this system could also apply more broadly to the progression of oncogenesis in other tissues, given the diverse roles that these transcription factors play \[[@B80-ijms-19-02074]\].

Ras/Raf-MAPK \[[@B81-ijms-19-02074]\], FGF \[[@B82-ijms-19-02074]\], and EGFR signaling \[[@B11-ijms-19-02074]\] all have well-documented roles in cancer progression as well, as is the case in ASP development. While the contributions of these signaling pathways are not unique to ASP development, the concurrence of their activities with ECM remodeling could enable the development of a holistic model for invasion that more accurately reflects both ASP migration and tumor metastasis, by extension, compared to other migrating cells. As such, drug screens targeting atypical signaling can reveal the impact of a treatment on processes ancillary to the


less is known about how Ser contributes to this structure's morphogenesis, though Ser is known to be EGF-like and facilitate position-specific cell proliferation in the wing and haltere imaginal discs \[[@B85-ijms-19-02074]\]. The transcription factors cut and knirps also have documented functions in morphogenesis---apoptosis inhibition \[[@B86-ijms-19-02074]\] and Dpp signal mediation \[[@B87-ijms-19-02074]\], respectively---but their role in ASP development is currently tentative and should be confirmed in order to derive a more complete model for invasive behavior.

The most imperative discoveries to be made regarding both tumor metastasis and ASP development may lie in the identification of novel regulators of ECM remodeling. In the ASP, many factors in this process require further investigation, especially the coupling of invasive migration with ECM degradation. Some contributors to ECM remodeling, including hypoxia \[[@B88-ijms-19-02074]\], have yetcandidates for therapeutic intervention as well. Likewise, establishing how CP1/CTSL facilitates ASP invasion, characterizing the signal released by MMP2 to laterally inhibit tip cell fate, and determining how proteolytic enzymes cooperate during ASP development might provide new insights regarding ECM remodeling in human cancer progression. Resolving the issue of how Spg integrates with the other signals that regulate MAPK activity could also be rather useful, given that DOCK3 and DOCK4 were previously shown to be required for the migration of melanoma \[[@B91-ijms-19-02074]\] and breast cancer \[[@B92-ijms-19-02074]\] cells, respectively, via activation of the Rho GTPase Rac. Furthermore, Rac's central role in actin remodeling \[[@B93-ijms-19-02074]\] should make further study of Spg and the potential roles of other DOCK family proteins of interest for modeling invasive biomechanics in the ASP.

Developing a


code:
    getFoo(): Observable<Foo> {
        return this.http
            .get<Foo>('/some/route/to/FooEndpoint')
            .pipe(
                map((res: Foo) => {
                    res.bar = new Map(Object.entries(res.bar));

                    let actualMapOfBar = new Map(Object.entries(res.mapOfBar));
                    res.mapOfBar = newusing the given cipher.Block. Prefix must be the first
// blockSize + 2 bytes of the ciphertext, where blockSize is the cipher.Block's
// block size. If an incorrect key is detected then nil is returned. On
// successful exit, blockSize+2 bytes of decrypted data are written into
// prefix. Resync determines if the "resynchronization step" from RFC 4880,
// 13.9 step 7 is performed. Different parts of OpenPGP vary on this point.
func NewOCFBDecrypter(block cipher.Block, prefix []byte, resync OCFBResyncOption) cipher.Stream {
	blockSize := block.BlockSize()
	if len(prefix) != blockSize+2 {
		return nil
	}

	x := &ocfbDecrypter{
		b:       block,
		fre:     make([]byte, blockSize),
		outUsed: 0,
	}
	prefixCopy := make([]byte, len(prefix))
	copy(prefixCopy, prefix)

	block.Encrypt(x.fre, x.fre)
	for i := 0; i < blockSize; i++ {
		prefixCopy[i] ^= x.fre[i]
	}

	block.Encrypt(x.fre, prefix[:blockSize])
	prefixCopy[blockSize] ^= x.fre[0]
	prefixCopy[blockSize+1] ^= x.fre[1]

	if prefixCopy[blockSize-2] != prefixCopy[blockSize] ||
		prefixCopy[blockSize-1] != prefixCopy[blockSize+1] {
		return nil
	}

	if resync {
		block.Encrypt(x.fre,


the emergent repertoire and at the level of export of newly formed cells into the periphery. This selective process results in the decreased peripheral representation of the VH 7183 family and in the accumulation of cells belonging to the other VH families. Selection of VH family usage in peripheral repertoires may be determined according to lymphocyte life-span, as we have found a preferential utilization of the VH J558 family in populations of partially enriched, long-lived B cells.for it, so I don't know what to call it in English either!

02-18-2005 04:27 PM

bert vosters

wobble flies

Hi It's Bert Vosters of Poseidon in the Netherlands.
The wobble flies were designed originally for large reservoir trout and asp.
But they also work excellent for bass, perch, salmon, ide, to name but a few. Most exotic report we received was from a friend who had caught tigerfish on the Zambezi river with the wobbler flies.
We had 5 sizes made, ranging from #5 (#10 nymph) to #1 (#9/0 pike lure).
The pattern pictured is just one of the endless possibilities this plastic bib can add to fly design.
The bibs are readily available through fly fishing shops in the Netherlands and they should be in the UK as well through Hopkins and Holloway, or Veniard.
Any


turle, another in-line knot without a loop.

The only conclusion I made from fishing a loop knot was a noticeable loss of strength in the knot when pulling out a snag, and an occasional loss of a large fish when using lighter tippets. I have abandoned them entirely, but who knows I could be missing something... or not.

Back on topic, wobbly flies are cool... this gives me a lot of ideas for flats flies!

07-07-2004 10:13 PM

Adrian

Thanks John!

HCDK, the original post was a question about flies that incorporate wobble effects into their inherent design.

As far as means of attachment goes, loop knots facilitate movement, they do not cause it!

You could get extra movement on any pattern by using something like a riffling hitch but that's not what this thread isbalance salt solution (EBSS). Neurons were then incubated in 95% N2 + 5% CO2 for 6 h. After OGD, normal neuron medium was re-applied for reperfusion and returned to regular atmospheric oxygen level in normal incubator. At 24 h after OGD, viability of neurons was assessed with immunofluorescence staining of NeuN (1:500, EMD Millipore, Billerica, MA). For calculation of lived neurons, we randomly selected four4 fields with microscope and counted the cells in the fields with ImageJ. Data were presented as NeuN^+^ cells/mm^2^.

Western blot {#Sec14}
------------

Protein isolation from cultured neutrophil was performed as previously described \[[@CR16]\]. Western blots were performed using the standard SDS-polyacrylamide gel electrophoresis method and enhanced chemiluminescence detection reagents (GE Healthcare Biosciences AB, Uppsala, Sweden). Antibodies against phosphorylated signal transducer and activator of transcription 1 (pSTAT1) (Multi-clonal, Abcam,


Y701), were downregulated by atRA treatment accordingly (Fig. [6](#Fig6){ref-type="fig"}e). We quantified the ratio of pSTAT1 to STAT1 and found that atRA did not alter the ratio of STAT1 phosphorylation (data not shown). It is known that phosphorylation and gene expression of STAT1 could be inhibited by suppressor of cytokine signaling 1 (SOCS1) \[[@CR29], [@CR30]\]. Therefore, protein level of SOCS1 in neutrophil after atRA treatment was assessed. Strikingly, atRA upregulated the protein expression of SOCS1 in neutrophil as measured with Western blot (Fig. [6](#Fig6){ref-type="fig"}e), which could downregulate expression of STAT1 protein and impede activation of STAT1 signaling. Fig. 6All-trans retinoic acid modified neutrophil functions through STAT1 signaling. **a**, **b** Expression of RAR-α, -β, and -γ in neutrophil was illustrated with immunofluorescent staining (**a**) and Western blot (**b**). **c** Heat map showingdriver and be able to spend some time this close to them and listen to them have a conversation with your daughter means a lot,” he added. “It is very special. It puts things on a personal level. They are celebrities, but they are also people, too, that have caring thoughts for others outside of (their) world.”

Thank you Becky, Marcus, and George for bringing a smile to our Hattie’s face today. Marcus, the Browns can’t wait to cheer for you on race day! 🏁🏎 pic.twitter.com/h4ZtitWMme — Matthew Brown (@EdTechMatthew) May 9, 2019

Hattie, who will soon turn 7, smiled when Ericsson handed her a hero card and he said, “I drive the No. 7 car.”

The smiles are what makes the Racing For Kids visits by drivers, owners and others


required quarters, and were found in places called "arcades." One such place used to exist at the Mesa Mall. Pong eventually gave way to Space Invaders, which gave way to "Asteroids," and then "Star Wars." Before you knew it, you had "Dragon's Lair." One could easily blow a paycheck in one afternoon at Aladdin's. Of course, this was back when the minimum wage was less than $3 per hour.

Getty Images

8

Talley's

600 block of Main Street

Have you ever been to a restaurant owned by a former professional wrestler? Talley's "Big Biscuit" was located on the 600 block of Main Street. Every radio jock, and half the employees at the IRS ate breakfast there every morning of their lives. Do you see that front door? None of the past patrons ofthis restaurant ever did. There was a parking area behind the building, and almost everyone entered the restaurant through the back by the kitchen. For breakfast, you could order the "Waylon." That was two eggs over easy, two strips of bacon, Grits, wheat toast, and coffee.

Google Maps

9

The Oasis Restaurant

Corner of 4th and North Avenue

The Oasis was the working definition of a "coffee shop." Every day of my childhood was spent there, and I think the only thing we ever had was coffee. I would go there with my dad in the early 1970's and pound coffee by the gallon. The booth seating was covered in duct tape, and the place was all the better for it. Eventually, for reasons unknown, the place changed its name to "The Prairie


sign featured a messed up neon giraffe and tiger. Their heads rocked back and forth all the time...constantly...ad nauseam... for all eternity. Every once and a while, a big name act would roll through the Caravan.

Robert Grant

All of these local businesses were great. Many of them enjoyed a long run. Who knows, they may one day come back around again. Graff Dairy did. Will Grand Junction one day see the return of Talley's? Here's hoping.Downtown Taxi

Taxi in the city centre

The Downtown Taxi is a taxi service based in Astoria Oregon. Eastlansing taxi services. Airport Lansing taxi taxi shuttle. East Lansing taxi services. Pick up at home, airport transportation, transportation of special events and more in Downtown Taxi in Bakersfield, CA, is what our taxi service offers.

Attendees, tourist, business travellers and locals in and around Los Angeles can quickly and easily make a taxi reservation in downtown Los Angeles and within a few moments drive our taxi application on smart phones, make an on-line reservation or call us at 888-248-9222. Visit Tinseltown, the entertainment capital of the world, our dear Los Angeles in classy comforts.

Included in our competitively priced prices is a $46.50 package plus a $4.00 handling charge from Downtown LA to


talk to someone, you can call a member of the disposition staff at 888-248-9222 for all your Los Angeles transport needs.

City Taxi Cab Inc 2410 Hollins St, Baltimore, MD 21223

When she didn't want to turn on the counter, she said that the prices were higher because of the heavy rain. When she picked up her dad, who had taken two coffee bottles with him, she said to me to get out when I said it was not ethical for her to raise prices. Driver are kind, car are neat and fare is lower, and there is never a disagreement about the fare or the use of credits card.

Display prices. Of course, the measuring device must have been manipulated because of the large differences. Due to my experiences withof the DPRK permitted tourists to ride six stations instead of only two. In 2014 it was allowed to fully explore the entire metro which allowed us to run our annual Entire Pyongyang Metro tour in September.

In 2015, the DPRK designed and assembled their very own modern train to operate on the metro. The carriages were fitted with LCD screens displaying arrival station information and playing DPRK documentaries during journeys such as apples grown in Kangwon province or soap produced at Pomhyangi Cosmetics Factory.

YPT group riding the modern subway

Entering Harvest station

Renovated Victory station

Locals waiting at Independence station platform

Platform conductor

They currently have only one modern train which has been dubbed the “prototype” and if you’re lucky enough you’ll see it pass on line 1 or have the chance to


suggestions?
MY CODE:
string encoder , string decoder, client handler , server handler , client main ,server main.
//Decoder=======================================================
import java.nio.charset.Charset;

import org.jboss.netty.buffer.ChannelBuffer;
import org.jboss.netty.channel.Channel;
import org.jboss.netty.channel.ChannelHandlerContext;
import org.jboss.netty.handler.codec.frame.FrameDecoder;

public class Dcd extends FrameDecoder {
    public static final Charset cs = Charset.forName("utf8");

    @Override
    protected Object decode(ChannelHandlerContext ctx, Channel channel,
            ChannelBuffer buffer) throws Exception {

        if (buffer.readableBytes() < 4) {
            return null;
        }

        int headlen = 4;
        int length = buffer.getInt(0);
             transferredBytes.addAndGet(((String) e.getMessage()).length());
        Channels.write(ctx.getChannel(), e.getMessage());
    }

    @Override
    public void exceptionCaught(ChannelHandlerContext ctx, ExceptionEvent e) {
        // Close the connection when an exception is raised.
        logger.log(Level.WARNING, "Unexpected exception from downstream.",
                e.getCause());
        e.getChannel().close();
    }
}

//Server main =======================================================
import java.net.InetSocketAddress;
import java.util.concurrent.Executors;

import org.jboss.netty.bootstrap.ServerBootstrap;
import org.jboss.netty.channel.ChannelPipeline;
import org.jboss.netty.channel.ChannelPipelineFactory;
import org.jboss.netty.channel.Channels;
import org.jboss.netty.channel.socket.nio.NioServerSocketChannelFactory;
import org.jboss.netty.handler.execution.ExecutionHandler;
import org.jboss.netty.handler.execution.OrderedMemoryAwareThreadPoolExecutor;

/**
 * Echoes back any received data from a client.
 */
public class EchoServer {

    private final int port;

    public EchoServer(int


Trump during their meeting in the Oval Office on Tuesday.CreditDoug Mills/The New York Times

• “It’s like a manhood thing with him — as if manhood can be associated with him. This wall thing.” Representative Nancy Pelosi had some choice words for President Trump after a televised Oval Office fight over a looming government shutdown. [The New York Times]

• A Los Angeles County sheriff’s deputy is being charged with voluntary manslaughter in the shooting death of an unarmed man at a Norwalk Gas station in 2016. It’s the first time since 2000 that a law enforcement officer in L.A. County has been prosecuted for an on-duty shooting. [The Los Angeles Times]

• On Tuesday, the House Judiciary Committee had the chance to question one of the most powerful people onexperimental research platform to support and evaluate a variety of other new concepts in online learning.

Problems
A problem is that the creation and maintenance of comprehensive OCW requires substantial initial and ongoing investments of human labor. Effective translation into other languages and cultural contexts requires even more investment by knowledgeable personnel.  This is one of the reasons why English is still the dominant language, and fewer open courseware options are available in other languages. The OCW platform SlideWiki  addresses these issues through a crowdsourcing approach.

Americas

Colombia
 Universidad Icesi, OpenCourseWare de la Universidad Icesi

Brazil
 Fundação Getulio Vargas (FGV Online)
 Universidade Estadual de Campinas

Mexico
 Universidad de Monterrey, 2007
 Universidad Anáhuac México Norte, 2010

United States

This listing is roughly in the order of adoption of OCW principles.
 Massachusetts Institute of Technology (MIT),


learning material. Japanese researchers have been particularly interested in the technical aspects of OCW, for example in creating semantic search engines. There is currently a growing interest for Open Educational Resources (OER) among Japanese universities, and more universities are expected to join the consortium.

“In order to become an integral institution that contributes to OER, the JOCW Consortium needs to forge solidarity among the member universities and build a rational for OER on its own, different from that of MIT, which would support the international deployment of Japanese universities and also Japanese style e-Learning.”

Iran
The "Maktabkhooneh ()" is an online educational platform in Iran which provides free online courses from universities in Iran. The motto of the Maktab-Khooneh is "Making Accessible Excellent High Quality Education For Every Iranian for Free".with complete recanalization of the main portal vein and its branches was achieved in 10 patients (efficacy, 77%). In the other three patients, necrosis of the HCC ranged from 70% to 90%, and recanalization of the main portal trunk was not complete. No major complications occurred. In three cases, mild to moderate ascites and increased aspartate aminotransferase and alanine aminotransferase levels were found. The follow-up periods ranged from 3 to 36 months among the treated patients and 2 to 10 months among the untreated patients. The cumulative survival rate was 77% 6, 12, and 36 months after procedure in the treated group and 43% and 0% 6 and 12 months after diagnosis in the untreated group (p < 0.0001). All 10 successfully treated patients were alive and the


the cluster size—which is now also a random variable—could then carry information about the quantities or parameters of interest. Recent examples of informative cluster size problems in the biostatistical literature include:

-   volume-outcome studies [@Panageas2007] where specialized surgeons treating many patients may have better outcomes than those treating few patients;

-   periodontal studies [@WilliamsonDattaSatten2003; @Wang2011] where patients with fewer teeth tend to have poorer condition of the still remaining teeth;

-   radiation toxicity studies [@Datta2008], where the number of measurements on successive measurement on an individual depends on the number of radiation therapies, which in turn depend on the underlying severity of cancer.

More examples are provided in @Dunson2003, @Williamson2007 and @Williamson2008, among others.

@Hoffman2001, in their original paper, defined *nonignorable cluster size* as any violation of(functionals) of different interesting characteristics of the population and then use the corresponding sample statistics as estimators. For example, if $Y_1,...,Y_M$ is a random sample from an unknown univariate distribution $F$, then for the sample mean $\bar Y=\frac 1 M
\sum_{i=1}^M Y_i$ and the sample variance $S^2=\frac 1M \sum_{i=1}^M
(Y_i-\bar Y)^2$, the corresponding functionals are the mean functional $\mu(F)=\int xdF(x)$ and the variance functional $\sigma^2(F)=\int(x-\mu(F))^2dF(x)$, respectively. Under general assumptions on $F$, two functionals $\mu_1(F)$ and $\mu_2(F)$ may recover the same value (*e.g.* the mean functional and the median functional in the nonparametric model of symmetric distribution) but the statistical properties (*e.g.* efficiency and robustness) of the corresponding estimates (the sample mean and the sample median) may be completely different. The functional approach has now been generally adapted in the robust


only depend on the random effect but not on the covariates, then a simple calculation shows that the corresponding components of the estimators without the $1/N_i$ weight also converge to the correct regression parameters. In other words, in such cases, the classical analyses will also work for such parameters but the estimates of the other parameters including the intercept terms will continue to be biased. @Benhin2005, @Gueorguieva2005, @Wang2011 and @Neuhaus2011, e.g., consider these types of results.

Regression M functionals
------------------------

In the univariate case, simultaneous (naive) M functionals $\beta(\mathds{P})$ and $\sigma(\mathds{P})$ for linear regression are given by equations $$E(w_1(R_{i1}) R_{i1}X_{i1})=0 \ \ \mbox{and} \ \ E(w_2(R_{i1})R_{i1}^2)=E(w_3(R_{i1})),$$ where now $$R_{ij}=R_{ij}(\beta,\sigma)=\frac {Y_{ij}-\beta'X_{ij}} \sigma,\ \ i=1,...,M;\ j=1,...,N_i.$$ Recall that, in maximum likelihood estimation, $$w_1(R)=w_2(R)= -\frac {f'(R)} {R f(R)} \ \ \mbox{and}\ \ w_3(R)\equiv 1,$$implies that (or can be formulated as) $$E^*[ T(Y_{1\alpha_1},...,Y_{M\alpha_M})]=0$$ where $E^*$ corresponds to the probability measure $\mathds{P}^\ast$ overlying the distribution of $\alpha_i,\,N_i,Y_{i1},\ldots,Y_{iN_i}$, plus the covariates $X_{i1},\ldots,X_{iN_i}$ in the regression case, if they are assumed to be random, too. An appropriate test statistic for this testing problem based on i.i.d. observations $ Y_{1\alpha_1},...,Y_{M\alpha_M}$ (plus covariates in case of regression) is simply given by $$\hat{T}^*=  T(Y_{1\alpha_1},...,Y_{M\alpha_M}).$$ As for example, if we are interested in testing $H_0:\ E^*(Y_{i\alpha_i})=0$, then the null hypothesis implies that also $E^*[ T(Y_{1\alpha_1},...,Y_{M\alpha_M})]=0$ with $T(Y_{1\alpha_1},...,Y_{M\alpha_M})=M^{-1}\sum_i  Y_{i\alpha_i}$. While $\hat{T}^*$ is a valid test statistic, it is objectionable: (i) this may be inefficient since a large part of the data will be ignored depending on which observations are chosen by the particular realization of the random indices


Retirement Fund and the German investment group Jamestown.

111 Eighth Avenue is among the world’s most wired buildings. It was originally built as the Port Authority Commerce Building in 1932, and was redeveloped for telecom use by Taconic in the late 90s. The offering is being closely watched as a barometer of the Manhattan real estate market.

Google's purchase of the building provides access to additional office space for its growing New York sales and engineering operation at 111 8th Avenue. As the building owner, Google has the ability to easily expand into vacant space if needed. About a quarter of the building is dedicated to data center and telecom space, but the tenant list also includes Deutsche Bank, Barnes & Noble, Armani, Nike and Lifetime Networks. Google is alsoRolls and Frederick Henry Royce teamed up to create the iconic brand. Rolls was the owner of several successful car dealerships, and Royce was an established automobile designer and engineer.

The company made their official debut in 1906, with the release of the Silver Ghost. The car caught the attention of the masses by breaking a world record – traveling nearly 14,500 consecutive miles. The emergence of the
Click Silver Ghost paved the way for one of the brand’s most popular models to this day – the Ghost series.

Rolls-Royce vehicles were originally purchased by the ultra-wealthy, but as WWI began to affect the European economy, fewer people were able to splurge on items like luxury cars. The brand’s founders shifted their attention to aviation efforts, which were used by the


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Terms and Conditions

1. Definitions. “Agreement” means all terms and conditions found in these Terms & Conditions, the Face Page, the Waiver and Assumption of Risk, any addenda and any additional materials we provide and that you sign at the time of rental. “You” or “your” means the person identified as the renter on the reverse, any person signing this Agreement, any Authorized Driver and any person or organization to whom charges are billed by us at its or the renter’s direction. All persons referred to as “you” or “your” are jointly and severally bound by this Agreement. “We,” “our” or “us” means the independent business named on elsewhere in this Agreement. “Authorized Driver” means: (a) the renter and the renter’s spouse; (b) additional drivers listed by usthan a minor traffic violation; (e) while pushing or towing anything, or in any race, speed test or contest, or while teaching anyone to drive the Vehicle; (f) while carrying dangerous or hazardous items or illegal materiel in or on the Vehicle; (g) outside the geographic limitations indicated elsewhere in this Agreement; (h) if the odometer has been tampered with or disconnected; (i) when the Vehicle’s fluid levels are low, or it is otherwise reasonable to expect you to know that further operation would damage the Vehicle; (j) to commit a willful, wanton or reckless act; (k) by anyone who is sending an electronic message, including text (SMS) messages or emails, while operating the Vehicle; or (l) in violation of any “Rules of the Road,” vehicle safety and


the units digit of r(h)?
8
Let t(x) = 24*x**3 - x. Let i be t(-1). Let z = 9 + i. What is the units digit of 3 - 2 - 2 - z?
3
Let z be -12*((-4)/(-6))/(-2). Let h = 8 - z. What is the units digit of h?
4
Suppose -5*o - 110 = -1115. What is the hundreds digit of o?
2
Let d(r) = -r - 17. Let w be d(-10). Let u = w - -12. Suppose -3*i - 5*l = -3, -2*i + 5*l = 3*i - u. What is the units digit of i?
1
Let r = -111 + 144. What is the units digit of r?
3
Let l(n) = n**3 - 8*n**2 + 7*n + 10. Let k be ((-21)/9 + 2)*-12. Let y be 50/8 +As wine editor of the San Francisco Chronicle, Jon Bonné is the leading voice in a general-interest publication covering the heart of the California wine industry. He’s also controversial, for he has been one of California wine’s harshest critics.

In “The New California Wine: A Guide to the Producers and Wines Behind a Revolution in Taste,” published in November by Ten Speed Press, Bonné argues that California’s wine industry has been on the wrong path for more than two decades, pursuing bigger, riper wines and higher point scores from critics at the expense of the character that made California wines great in the first place.

“Again and again I was disappointed by what I found to be the shortfalls of California wine: a ubiquity of oaky, uninspired bottles and a


ability to detect and diagnose cancer through the detection of tumour or cancer markers is an area of widespread interest and as a consequence the need exists for reproducible and reliable methods of identifying new and more useful cancer markers in patient specimens.
Glioblastoma is the most common and most aggressive type of primary brain tumor in humans. The disease is difficult to diagnose and even harder to treat due, in part, to the blood-brain barrier that hinders the delivery of therapeutic agents and detection of potentially important diagnostic markers. Diagnostic markers for glioblastoma are available, but are specific for the tumour tissue itself and require a tumour sample.
Improved screening and detection methods are needed in order to detect cancer in an early phase and to follow the progressionthe identification of specific compounds, for instance proteins, in various body fluids as markers of disease, such as cancer, has been hampered by the lack of suitable techniques therefore.
Also in case of diseases other than cancer, markers may be available that are difficult to detect. This hampers early diagnosis of the disease.
The present invention aims to overcome the problem of the prior art that not all diseased tissues or disease types (e.g. tumours) result in circulating disease cells (e.g. circulating tumour cells). The present invention also aims to overcome the problem that protein markers for detecting diseases such as cancer are difficult to detect. Further, the present invention aims to provide methods that do not require biopsies, and allow extensive monitoring of patients.


time and money on having your hair dye and lipstick complement your eye color and then have the best glamour photography to make your eye color as readily apparent as her's in her column photo.

By the way, can we finally lose the term "white-bread?" I suspect that for a few decades now, blue-eyed people eat less white bread per capita than brown-eyed people.

The point of having an invitation-only closed email list is to let people say and hear in private the insightful things that it would be bad for their careers to say and hear in public.

Yet, the liberal reporters and pundits on the JournoList closed email list apparently view their list as an opportunity to exchange with each other exactly the same ignorant eye-rolling, the same politicallygiven in Puerto Rico, but the LSAT is only given in English. Puerto Rico has its own little universe of colleges and law schools that nobody in America has ever heard of because they use Spanish as their language of instruction, but the LSAT is so useful that Puerto Rican law schools insist on their applicants taking it (along with a GRE-like test in Spanish).

The LSAT is one test where African-American men outscore African-American women, but only about 60% as many black men take the test as black women.

Le Carrefour goes on to offer an LSAT to IQ conversion chart. I suspect, however, that it slightly underestimates IQs relative to LSAT scores. It assumes that somebody who scores 151 on the LSAT has an IQ of 105, which


that there's this giant homeschooled mulatto kid and his older brother on one of those schools in Oklahoma.

Personally, I would like to see college players stick around longer. For example, Kevin Love was an All-American as a freshman last year at UCLA because of his Bill Walton-like skills. His father Stan Love played for Portland in the NBA. (His father's brother Mike Love is a Beach Boy.) He looked awesome through the first four rounds of the tournament, until he ran into Memphis's NBA-quality athletes in the semifinal, where he looked short and slow.

So, he might not have personally carried UCLA to an NCAA championship, but what a team player to recruit around. If he had announced he was staying all four years, UCLA could have recruited starof business with the federal government. Perhaps, though, this whole distinction between private for-profit businesses versus government entities has become academic in the Bush-Obama Era.

For 20 months now, I've been reading about how it's completely beyond the power of human comprehension to untangle mortgage backed securities and figure out about what they are really worth, that no mortal man could possibly understand their complexity, that not enough computing power exists to make sense of them. I guess I kind of believed that when I heard it back in August 2007, but that was a long time ago.

I suspect that insiders have been working hard on this question for some time, and Tim Geithner's new "legacy asset" plan has come along at just the right time for them to