reversed the

agency and held the claimant bears the burden to demonstrate that the

injury arose out of and in the course of employment and therefore, to

demonstrate the injury was not the result of horseplay. It appears the

district court did not reach an ultimate conclusion on the merits of

whether Vegors’s alleged horseplay bars recovery because the court went

on to hold Vegors’s recovery was barred under a separate affirmative

defense, which we will address below.
                                    6

      Employers are required to compensate employees for “personal

injuries sustained by an employee arising out of andThe employer argued that the

employee’s travel home from the plant was not in the course of
                                     8

employment and that the employee deviated from his employment by

taking the more scenic route home.       Id. at 150, 153.   The employer’s

arguments were meant to contest whether the injury arose out of and in

the course of employment.       The burden, however, remained on the

employee and did not shift to the employer. Id. at 150.

      Similarly, Vegors retains the burden


states have enacted statutes comparable to

section 85.16(3).     Regardless of whether states have enacted such

statutes, “it is almost universally held that when the animosity or

dispute which culminates in the assault is imported into the place of

employment from the injured employee’s private or domestic life, the

injury is not compensable, at least where the animosity is not

exacerbated by the employment.” Commercial Standard Ins. Co. v. Marin,

488 S.W.2d 861, 864 (Tex. Civ. App. 1972).

      The potential application of section 85.16(3) in this case gives rise

to three issues:     (1) whether the statute’s reference to third parties
                        v. Moosbrugger, . . . “[f]or workmen
      of that age or even of maturer years to indulge in a moment’s
      diversion from work to joke with or play a prank upon a
      fellow workman, is a matter of common knowledge to every
      one who employs labor.”
                                          17

Leonbruno v. Champlain Silk Mills, 128 N.E. 711, 711 (N.Y. 1920)

(quoting Hulley v. Moosbrugger, 93 A. 79, 79 (N.J. Sup. Ct.


apply
    {
        typedef apply type;
        BOOST_STATIC_CONSTANT(int, value  = 0);
    };
};

template< typename T > struct greater_tag
{
    typedef typename T::tag type;
};

template<
      typename BOOST_MPL_AUX_NA_PARAM(N1)
    , typename BOOST_MPL_AUX_NA_PARAM(N2)
    >
struct greater

    : greater_impl<
          typename greater_tag<N1>::type
        , typename greater_tag<N2>::type
        >::template apply< N1,N2 >::type
{
};

BOOST_MPL_AUX_NA_SPEC2(2, 2, greater)

}}

namespace lslboost { namespace mpl {

template<>
struct greater_impl< integral_c_tag,integral_c_tag >
{
    template< typename N1, typename N2 > struct apply

        : bool_<could you
please let us know  how many originals of the Letter Agreement were signed??
The lenders also  need an original of this document.
?
Thank you in  advance
Isabel

Isabel Parker
T? +1 212 277 4025
F? +1 212  277 4001
E? isabel.parker@freshfields.com
520 Madison  Avenue
34th Floor
New York, NY 10022
www.freshfields.com
?
?


say it — and the world — will get hotter without a course correction. What is your plan to combat climate change?

We definitely should rejoin (the Paris Agreement). We need a carbon fee and dividend model, and I think we can rebate the full value of that out to the American people on a progressive basis so that most Americans are made better off than before.

Even that’s not going to be enough.

We need to massively increase federal (research and development) on not just renewable energy, but energy storage and carbon storage. I think that we should set this to over $20 billion. Something that would be comparable would be the level of investment that you saw on something like the Manhattan Project or the Apollo project, because thisreally is the challenge of our time.

And it’s hitting every part of the country in different ways. I talked to my fellow mayors in Florida; they’re dealing with sea-level rise. In my own community in the Midwest, we’ve dealt with once-in-a-lifetime flooding happening almost every year.

In many parts of the country, including here, we’re seeing tremendous promise for the renewable energy economy. You look at what’s happening in the solar industry here, and it’s one of many ways that I feel like I’m glimpsing the future whenever I come to this state.

We see there’s a lot of job creation available to us as we do what we must do as a country, which is step up aggressively to tackle the climate challenge.

How are you different from the other


than our parents.

I served in the Afghanistan war, and the inability to end these forever wars has affected me and my generation deeply. I’m from a community in the American industrial Midwest that has been ravaged by the failure of our economy to take care of most Americans.

I’ve seen firsthand the problem but also the solutions that are at hand.

The way that local communities are stepping up to solve problems and the fact that we can take on these serious, structural reforms that are actually going to give us an economy and a democracy that works for us so that when we do get to 2030, which isn’t that far off, we can look back and be proud of what we did now.

Whether it’s on climate, on gunthings, calling a former girlfriend and her mother on
multiple occasions and ignoring the direction of his probation
officer not to do so. Defendant contested the allegations and,
following a hearing, County Court determined that defendant had
                              -2-                106005

violated the terms of his probation. Defendant was thereafter
resentenced to two years in prison, to be followed by three years
of postrelease supervision, and he now appeals.

      The People bear the burden of proving a probation
violation by a preponderance of the evidence (see CPL 410.70


NY3d 1021 [2013]; People v Brickle, 244 AD2d 700,
702 [1997], lv denied 91 NY2d 889 [1998]).

      Defendant additionally argues that County Court failed to
provide an adequate statement of its reasoning in revoking his
                              -3-                  106005

probation (see Gagnon v Scarpelli, 411 US 778, 785-786 [1973];
People v McCloud, 205 AD2d 1024, 1025 [1994], lv denied 86 NY2d
738 [1995]). Defendant failed to preserve that argument by
objecting to the sufficiency of County Court's findings, however,
and we perceive no reason to take11 HLP III patients with discrepancies demonstrated the presence of six carriers of the epsilon 3(Arg136-->Ser) allele and three carriers of the epsilon 2(Gly127-->Asp) allele. Five HLP III patients were apo E2/E2 using IEF, but only 2 of them were epsilon 2 homozygous using PCR. Two patients were E3/E3 homozygous with normal DNA sequence in the low density lipoprotein receptor binding domain of apo E. In conclusion, our results show that a number of different apo E genotypes are associated with HLP III in this population. More specifically, mutations at positions 127 and 136 might be frequent in Spain and occur in patients with HLP III.


Friday, May 10, 2013

Still at the Beginning

Everything always takes longer than expected, and even the best-planned project usually takes at least twice as long as one thinks it will. In short, the sheltered area under the eaves that was supposed to be paved weeks ago is not finished yet; first the bad weather and

then the holidays caused a delay in accomplishing the goal. Until this new sheltered place is completely fixed, everything else will have to wait. There's so much more to be done and time is passing by way too fast!

Renovating the only cat room in the front yard will be a big challenge, as all of the furniture needs to be moved into the sheltered area under the eaves that the workers are currently working on,the outdoor fence posts are crumbling, the entire chain link fence is barely holding up and almost all of the walls on the property, which were originally made of bricks and

rammed earth, are soaking wet inside. Damp patches are forming both on ceilings and walls in the house and pretty much everything is falling apart. If the building starts to collapse in on us, no one here will be happy and relaxed anymore and we'll be in serious

trouble.

Please, take a look at our project! We have accomplished a lot already, but more needs to be done; it's not only risky, but it’s dangerous to stop halfway through. Once we're over these hurdles and everything's been

repaired, the shelter will just need to be maintained in the years to come


bud, respectively). Thus, overall the enrichment of pollen‐expressed genes does not appear to be a simple function of the Y degeneration of genes not expressed in pollen. However, it is possible that any signal of early enrichment may have been eroded by extensive Y degeneration in the more degenerated *R. rothschildianus* and possibly secondary movement of genes on and off the X chromosome.

Because Y‐chromosome degeneration alone is not sufficient to explain the enrichment of pollen expression on XY linked genes, we investigated whether adaptive linkage (Fig. [1](#evl360-fig-0001){ref-type="fig"}A), and/or pollenization (Fig. [1](#evl360-fig-0001){ref-type="fig"}B) of the Y chromosome could account for differential pollen expression between sex‐linked and autosomal genes. The sex‐linked genes in *R. rothschildianus* and *R. hastatulus* have arisen independently (Crowson et al. [2017](#evl360-bib-0008){ref-type="ref"}), thus ancestral expression of XY‐linked genes in one speciessystems.

Note that given our data it is difficult to definitively disentangle the possible effects of pollenization and adaptive linkage on Y chromosome evolution. We cannot differentiate between a scenario where alleles that are overexpressed in the haploid phase are recruited to the Y (via adaptive linkage), or a scenario where haploid beneficial alleles are further upregulated in the haploid phase post linkage (pollenization). Both scenarios are, however, likely complementary and point to the importance of sex‐specific haploid selection during plant Y chromosome evolution.

Given the evidence for pollen specialization on the Y chromosome, the early stages of sex chromosome evolution in *Rumex* may have been driven by haploid selection. It has been proposed that this should lead to male‐biased sex ratios in populations (Scott and Otto [2017](#evl360-bib-0034){ref-type="ref"}). But contemporary


severe enough to drive down haploid fitness on the Y, leading to female‐biased sex ratios over time (Scott and Otto [2017](#evl360-bib-0034){ref-type="ref"}). This view of sex ratio evolution is consistent with comparative data that indicates that plant species with homomorphic sex chromosomes tend to have male‐biased sex ratios whereas those with heteromorphic sex chromosomes exhibit female‐biased sex ratios (Field et al. 2013). Furthermore, theoretical work indicates that female‐biased sex ratios can be maintained in populations following deleterious mutation accumulation on the Y (Hough et al. [2013](#evl360-bib-0018){ref-type="ref"}). Thus, while explicit modeling of this process has yet to be conducted, empirical and theoretical work does suggest that Y degeneration can lead to female‐biased sex ratios in older, heteromorphic sex chromosomes, despite a history of specialization for haploid expression on the Y.

It is importantand encouraged people to embrace the mission of producing righteous offspring, Islam recognizes that obliging everyone to bear children while disregarding their respective circumstances is impractical. In other words, Islam teaches Muslims that childbearing for those who are capable of it is a blessing, but also recognizes that circumstances may not always allow for it. In classical books of Islamic jurisprudence, circumstances such as the capability of a woman’s health to sustain a pregnancy, or a man living away from his wife for an undetermined period of time, are discussed thoroughly in the framing of this discussion.

The vast majority of fuqahâ’ (jurists)—past and present—hold that temporarily putting off childbearing is permissible on an individual basis, but not as a societal ideal which overrides the default encouragement to have


becomes more contentious and, in some cases, an unlawfully aborted pregnancy[6] according to some Muslim scholars.

Abortion

Generally speaking, Muslim jurists have always viewed the fetus as the precious origin of human life. The womb is perceived as a fragile vessel that carries a unique human soul, and hence deserves safeguarding and careful treatment. The Qur’an states:

“And it is not lawful for them to conceal what Allah has created in their wombs if they believe in Allah and the Last Day.” [al-Baqara (2): 228]

The “womb” is sacred, as are the bonds formed through it. In a Qudsi hadith, God says: “I am Allah, and I am ar-Raḥman (the Most Merciful) who created the raḥim (womb), so whoever stays connected with it (i.e., womb relations), I will connect him [to MyIbn Juzzay.

[13] Abortion Due to Family Issues (taken from www.drhatemalhaj.com).

[14] Pope Francis denounces ‘horror’ of abortion. (2014, January 14). Retrieved February 10, 2017, from http://www.bbc.co.uk/news/world-europe-25723422

[15] John Paul II. Vatican. Evangelium Vitae. 25 March 1995. 19 March 2013. http://www.vatican.va/holy_father/john_paul_ii/encyclicals/documents/hf_jp-ii_enc_25031995_evangelium-vitae_en.html

[16] Johnstone, Brian V. (March 2005). “Early Abortion: Venial or Mortal Sin?”. Irish Theological Quarterly. 70

[18] Communications, U. M. (n.d.). Social Principles: The Nurturing Community. Retrieved February 10, 2017, from http://www.umc.org/what-we-believe/the-nurturing-community

[19] Life Library – Abortion. (n.d.). Retrieved February 10, 2017, from http://www.lcms.org/page.aspx?pid=849

[20] A Christian presence in every community. (n.d.). Retrieved February 12, 2017, from https://www.churchofengland.org/our-views/medical-ethics-health-social-care-policy/abortion.asp

[21] American Baptist Resolution Concerning Abortion And Ministry In The Local Church, 12/87. Online: http://www.abc-usa.org/wp-content/uploads/2012/06/Abortion-and-Ministry-in-the-Local-Church.pdf

[22]The Church of Jesus Christ of Latter-day Saints. (n.d.). Retrieved February 9, 2017, from http://www.lds.org/ldsorg/v/index.jsp?locale=0&sourceId=43de991a83d20110VgnVCM100000176f620a____&vgnextoid=e1fa5f74db46c010VgnVCM1000004d82620aRCRD

[23] American Baptist Resolution Concerning Abortion And Ministry In


counterterrorism efforts?

After 15 years of letting the military take the lead in fighting terrorism, policymakers need to accept that political problems demand political and diplomatic solutions, which are seldom found on the path of least resistance. But the tools needed — robust diplomacy, accountability mechanisms, democracy support — are starved of funding.

As U.S. military assistance grows every year, support for democracy shrinks. During Obama’s tenure in office, democracy assistance funding has declined by almost 30 percent. And while the Pentagon is slated to receive over $600 billion in funding, the State Department and foreign aid account will be lucky to get $50 billion.

By relying on military aid, the United States is fostering a world of endless war and insecurity. For the United States’ so-called security partners, that’s good(GWPH) develops and commercializes plant based cannabinoid therapies. Its key drug Epidiolex is marketed for the treatment of seizures associated with LennoxGastaut syndrome and Dravet syndrome. And with a strong Epidiolex launch and uptake trends so far, management is already demonstrating impressive execution in a very competitive market.

Most notably, GWPH has just reported Epidiolex revenues of $33.5M, more than double some estimates, thanks to uptake among new patients and the transition from expanded access and open-label extension programs (EAP/OLE) to commercial product. Even more importantly, the company also shared positive topline results from a Phase 3 study of Epidiolex in patients with seizures associated with tuberous sclerosis complex (TSC).

Such strong earnings prompted Oppenheimer’s Esther Rajavelu to upgrade GWPH from ‘Hold’ to ‘Buy.’ Following this upgrade, GWPH has now


be submitted in Q4.

Interestingly, UK-based GWPH also boasts a ‘perfect’ Smart Score of 10/10. This new rating system compiles 8 different data sets- from analyst ratings to the latest insider activity- to rank stocks out of ten. Here GWPH scores highly not just with the analysts but also with both bloggers and hedge funds. That’s alongside Very Positive news sentiment, and positive momentum with shares up 22% over the last year. (See GWPH’s price targets and analyst ratings on TipRanks)

Aphria Still Rides on a Wave of Positive Analyst Sentiment

GWPH isn’t the only cannabis stock out there with strikingly positive Street sentiment. Canadian cannabis giant Aphria (APHA) has also received only buy ratings from analysts in the last three months. That’s despite a horrific 2018 featuring a takeover attemptGMP FirstEnergy. This is one of the Top 20 analysts ranked by TipRanks out of over 5,190 analysts thanks to his savvy stock picking skills. He reiterated his buy rating on CGC with a C$72 price target- having upgraded the stock from Hold to Buy in April following the news that CGC has acquired the rights to snap up organic cannabis company Acreage Holdings.

As far as the Street is concerned, this deal provides CGC with a straightforward “path for the U.S. cannabis market.” Landry himself writes “This transaction should boost Acreage’s ability to consolidate the U.S. market.” That means “when Canopy officially takes ownership of Acreage, it could be much larger than currently.”

The analyst has now returned from a very insightful tour of the company’s activities in British


absolute zero temperature) to considering finite temperature property, which can qualitatively capture tendency of the above deviation. We will introduce projected density of microscopic states for *non-interacting* system along specially selected direction on configuration space, and show how their landscape relates to temperature dependence of internal energy in equilibrium state.

Concept and methodology
=======================

We first briefly explain the concept of CP, and then, show how the information of CP can be extended to capture finite temperature property. In classical systems, potential energy $E$ (or other physical quantities) for any microscopic state $d$ can be given by a linear combination of complete basis functions ($q_s$) for configuration space: $$\begin{aligned}
\label{eq:ce}
U ^{\left(d\right)} = \sum _{s=1} ^{g} \Braket{U|q_s}q_s ^{\left(d\right)},\end{aligned}$$ where $\Braket{\quad|\quad}$ denotes inner product on configuration space. Since $\Braket{U|q_i}$ is constant in terms of             The common usage of motor vehicle sales implies that a
                sale take place and service implies that there is some sort of
                maintenance being performed on the vehicles. As the
                evidence indicates, no sales or service were performed on
                the vehicles on the lot, and testimony was given that there


Service.”); 18 (“[T]he Property is used as
an overflow lot for car storage.”).9 On this understanding, the “sale” or “service” of a
motor vehicle is a forthcoming event that will ensue (if at all) when Richland
transports the vehicles to its auto dealership, which is located off-site and in another
zoning district.
                In a seeming effort to escape this result, the Town describes vehicle
storage as an “accessory use” and associates it inexorably with the primary use of
Motor Vehicle Sales and Service, therefore implying that the two are conjoined and
cannot be considered as separate uses. See Town’s brief at 8 (“Storage of excess
inventory accessory to an off-site automobile dealership is not one of the commercial
uses permitted.”).
      9
expressly permit a use does not mean that it prohibits that use.” Pegasus Tower Co.,
LTD. v. Upper Yoder Township Zoning Hearing Board (Pa. Cmwlth., No. 192 C.D.
2017, filed January 23, 2018) (unreported), slip op. at 1110 (quoting APT Pittsburgh
Limited Partnership v. Lower Yoder Township, Cambria County, 111 F. Supp. 2d
664, 670 (W.D. Pa. 2000)). Rather, if the Ordinance is silent on the issue, as the
Town contends, see Town’s brief at 9-10, then it expresses no view as to whether the
use is permitted or prohibited.11        In this circumstance, where there are two equally
opposing inferences, nothing is actually proved, see Commonwealth v. Borrin, 12
A.3d 466, 475 (Pa. Super. 2011) (en banc), and the lingering doubt is one which must
be


in the Ordinance stating, or having the effect of
stating, that a use which is not permitted is one that is prohibited. Cf. Bevans v. Township of
Hilltown, 457 A.2d 977, 980-81 (Pa. Cmwlth. 1983). Based upon our review, section 1341.21 of
the Ordinance appears to refute any notion that a use that is neither prohibited nor permitted is one
that is necessarily prohibited. Pursuant to this provision, the Ordinance seems to leave open the
possibility that any use is presumptively permitted, at least as a special exception, by categorizing
“[o]ther types of land uses, not specifically identified, regulated or recognized” and stating that
“[a]ll undefined or other reasonable land uses that are not otherwise regulated . . . shall be
considered a Special Exception use in its zoning district as determined by the . .          In its brief, the Town references sections 1341.09 and 1341.10 of the Ordinance,
pertaining to vehicle storage and off-site parking lots, but it does not press the matter further.
Specifically, the Town does not argue that sections 1341.09 and 1341.10 are applicable, much less
that Richland violated them. The Town also does not assert that Richland needed a special
exception to store vehicles on the property under section 1341.21.

        In any event, these sections, and any theories of noncompliance that could accompany them,
were not listed or contained in the enforcement notice; therefore, they cannot serve as a basis for
concluding that Richland violated the Ordinance. See section 616.1(c)(3) of the Pennsylvania
Municipalities Planning Code (MPC), Act of


July 31, 1968, added by the Act of December 21,
1988, P.L. 1329, as amended, 53 P.S. §10616.1(c)(3) (“An enforcement notice shall state . . . [t]he
specific violation with a description of the requirements which have not been met, citing in each
instance the applicable provisions of the ordinance.”); see also City of Erie v. Freitus, 681 A.2d
840, 842 (Pa. Cmwlth. 1996); Township of Maidencreek v. Stutzman, 642 A.2d 600, 601-02 (Pa.
Cmwlth. 1994) (setting aside relief granted to a township where “the notice neither mention[ed] the
specific ordinance section number, nor correctly describe[d] the applicable district.”).

       13
           This is particularly warranted considering that the Town has not proved that the use is
currently in nonconformity withTribe consists of like-minded business owners coming together with the intent of affecting positive change in the world. We share a common passion centered around Inspiring Authors, Encouraging Entrepreneurs & furthering knowledge via Self-Awareness, Health & Wellness, Corporate Behaviors, Domestic Violence & Business Acumen.

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Partnering with me to do a FREE Guest Expert interview inside Kickass LEADS is an excellent way to get your message & brand out into the world on a larger scale. And, check out all of the the options available inside my Kickass Sponsor Package Collection. Successfully building a connection with me will lead to New clients that will help to grow your business, Opportunities, Other Expert Advice, Raise your profile & Success Center Goodies (FREEBIES + Special Offers). Also, I'm a


knowledge to share with my clients.”

- Gwendolen Wilder

Don’t Miss Out On This Incredible Opportunity!

Rockstar, this is your moment! Welcome to the Wilder Tribe (Guest Expert Program)! You've visited at the right time my friend. I'm thrilled to see if you are a great fit for my Team.

Whether you're a FREE Guest Expert inside Kickass LEADS or a Paid Sponsor...The sky's the limit! But, here's a few ways we can Team up: Joint Webinar, In person- event/meetup, Live Stream TV Interview, Reciprocal Social Media Share & of course my favorite; being a Guest Speaker during each others programs and events. Primarily, I will host an opportunity to interview with you via video, in studio and/or you will provide a Facebook Live training. And, we can't forget about the *far behind. I love Mr Wazoo's gardens. There is always a surprise there.

The red and yellow roses are blooming like crazy!

More iris coming, too.

Mr W is putting on the peony hoops. This year's crop of buds is impressive!

A few leftovers for supper, some Netflix, and off to bed! Until tomorrow...

Monday, April 17, 2017

Not a lot of conversation in the studio today, just loads of work. Mr Wazoo did three small table runners before heading outside, and I spent the entire day (almost...) on this storm at sea quilt. The customer wanted the two heart shapes in the piecing to stand out in the quilting. It was a light custom job, so there was no stitch in the ditch and oodles of swirly background quilting. I did the entire


the solar cells, so that there is a need to supply a large amount of low-cost material of the solar cells.
In order to solve the above problems, a method for synthesizing highly pure carbon and highly pure silica, and then reducing it in a reduction furnace with a highly pure furnace material to synthesize highly pure silicon has already been proposed. The method, however, causes problems such as difficulty in scale-up, a low yield, and difficulty in reducing cost. Another method for reducing silicon tetrachloride with aluminum has been also proposed (see the following Non-patent Document 1, Patent Document 1, and Patent Document 2). However, in this method phosphorus in aluminum remains in silicon and makes it difficult to achieve a desired purity.
Other proposals have been made suchTsars. The term Little Russia has been used in Ukrainian chronicles by Samiilo Velychko, in a chronicle of the Hieromonk Leontiy (Bobolinski), and in Thesaurus by Archimandrite Ioannikiy (Golyatovsky).Русина О. В. Україна під татарами і Литвою. – Київ: Видавничий дім «Альтернативи», 1998. – с. 279.

The usage of the name was later broadened to apply loosely to the parts of Right-bank Ukraine when it was annexed by Russia at the end of the 18th century upon the partitions of Poland. In the 18th and 19th centuries, the Russian Imperial administrative units known as the Little Russian Governorate and eponymous General Governorship were formed and existed for several decades before being split and renamed in subsequent administrative reforms.

Up to the very end of the 19th century, Little Russia was the


a**4/24 + 57*a**2. What is b(1)?
-2
Let a(k) = 7 + 85*k - 40*k - 42*k. What is a(-4)?
-5
Suppose -22*y - 11 = -23*y. Let o(j) = -j**2 + 10*j + 16. Determine o(y).
5
Let a(n) = -4*n**2 - 36*n - 7. Let r(c) = -c**2 - 9*c - 2. Let i(y) = -2*y**2 - 18*y - 4. Let j(x) = -3*i(x) + 5*r(x). Let o(g) = 2*a(g) + 9*j(g). Give o(-7).
-10
Let b(i) = -4*i**3 - 11*i**2 - 3*i - 1. Let y(n) = -5*n**3 - 12*n**2 - 4*n. Let p(k) = -4*b(k) + 3*y(k). Give p(-8).
4
Let m(r) be the first derivative of -r**5/60 - 5*r**4/12 - 13*r**3/6 + 11*r**2/2 + 1. Let d(k) be the second derivative of m(k). Calculate d(-9).
-4
Let b(p) be the third derivative of p**6/120 -= -9*r - 0*r. Give v(r).
-5
Let p(q) be the third derivative of -q**5/30 + 17*q**4/24 - 186*q**2. What is p(7)?
21
Let k(x) = x**3 + 29*x**2 + 78*x - 2. Let l be k(-26). Let g(f) = f + 1. Let i(t) = -1. Let v(q) = g(q) + 3*i(q). What is v(l)?
-4
Let a(f) = 2 + 7*f + 5 + 5*f**2 - 4*f**2. Suppose -41 = 5*j - 4*r, -6*j + 3*j - 2*r = 7. Determine a(j).
-3
Let x be 226/12 + (-8)/(-48). Let p = x - 39. Let m be 3*p/(-24)*-2. Let w(h) = h**2 + 3*h - 3. Give w(m).
7
Let g(i) = 27*i**2 - 4*i + 20. Let o(a) = 3*a - 2*a - 2*a + 1 + 3 + 5*a**2. Let t(y) = -2*g(y)


= 91*f**2 - 47*f + 16. Let m(x) = 34*x**2 - 16*x + 5. Let v(q) = 8*m(q) - 3*y(q). What is v(10)?
22
Let q(z) = 36 - 62 - z + 22 + 36. What is q(0)?
32
Let j(q) = q**2 - 5*q + 6. Let w be j(6). Let g(i) be the second derivative of i**5/20 - i**4 - i**2 + 151*i + 3. Give g(w).
-2
Let c(k) = -4*k**2 - 24*k + 4. Let p(b) = -3*b**2 - 16*b + 3. Let r(d)

One of the most important plus size fashion tip is to choose clothes according to your exact dimension. You should never take fashion inspiration from a skinny model. At the same time, there is no reason why fuller-figured women should hide behind baggy, boring clothes.

1 Not Too Tight!

Tight clothing on a plus sized body will exaggerate your weight. Better, get clothing that will fit you and forget about the size tag. Even if it means you need to start wearing plus size women’s clothing.

2 Not Too Baggy Either!

Most larger women choose oversize clothing. The idea here is hiding their body. But the truth is they are only drawing more attention to their body. Your clothes must skim your body, no matter what your size or shape.

3 Choose Dark


Q:

Is the module of invariant differential forms of a Neron model of an abelian variety a projective module?

Let $A$ be an abelian variety of dimension $d$ over a number field $K$. Let $\mathcal{A}$ be its Neron model over the ring of integers $O_K$. Let $\Omega_{\mathcal{A}/O_K}$ and $\Omega_{A/K}$ be the sheaves of differential forms of $\mathcal{A}$ and $A$ respectively. Then $\Omega_{A/K}$ and  $\Omega_{\mathcal{A}/O_K}$ are locally free $O_A$ and $O_{\mathcal{A}}$-modules respectively as $A$ and $\mathcal{A}$ are smooth group schemes.
Furthermore, $\Omega_{A/K}$ is a free $O_A$-module, generated by invariant differential forms (cor 3, page 102, Neron Models, Bosch-Lutkebohmert-Raynauld).
Let $\Omega_{\mathcal{A}/O_K}^{inv}(\mathcal{A})$ and $\Omega_{{A}/K}^{inv}({A})$ be the subset of invariant differential forms of $\Omega_{\mathcal{A}/O_K}(\mathcal{A})$ and $\Omega_{{A}/K}({A})$ respectively.
I know that $\Omega_{{A}/K}^{inv}({A})$ is a $d$-dimensional $K$-vector space. Is it true that $\Omega_{\mathcal{A}/O_K}^{inv}(\mathcal{A})$ is a projective $O_K$-modulesVideo: Nixon “Happy F*KNG Trip’

For 10 days, a handpicked group of European elite riders including Chris Pfanner, Javier Sarmiento, JB Gillet, Alain Goikoetxea, Alex Mizurov and Antony Lopez took off to discover concrete playgrounds from Northern Spain up to the Southeast of France. Showcasing solid skills and putting the spotlight on extraordinary spots between Bilbao, Barcelona and Lyon, the guys lived the true spirit of a skate roadtrip and produced some great footage. In the style of other Nixon events like the Nixon Surf Challenge or Jibfest, the main goal of the â€œHappy F*KNG Tripâ€ was having a good time in a relaxed atmosphere while enjoying to skate together.


mm (range)274 (208--396)274 (196--432)NS^[a](#trx014tfn2){ref-type="fn"}^276 (200--432)272 (196--398)NS^[a](#trx014tfn2){ref-type="fn"}^274 (196--432)Morbidity on day of enrolment: % with diarrhoea at enrolment (n/N)6.5% (14/216)12.3% (35/285)0.038.3% (21/253)11.3% (28/248)NS9.8% (49/501) % with coughing at enrolment (n/N)37.0% (80/216)40.4% (115/285)NS34.8% (88/253)43.2% (107/248)NS38.9% (195/501)Previous health events: % with one or more hospital admissions before enrolment (n/N)3.2% (7/216)3.9% (11/285)NS4.4% (11/253)2.8% (7/248)NS3.8% (19/501) % received oral polio vaccine at birth (n/N)86.6% (187/216)88.1% (251/285)NS89.3% (226/253)85.5% (212/248)NS87.4% (438/501) % received BCG vaccine at birth (n/N)100% (216/216)99.3% (283/285)NS99.2% (251/253)100% (248/248)NS99.6% (499/501)Socio economic indicators: % with electricity installed (n/N)51.9% (112/216)47.7% (136/285)NS48.2% (122/253)50.8% (126/248)NS49.5% (248/501) % with functioning electricity, if electricity installed (n/N)65.2% (73/112)72.1% (98/136)NS72.1% (88/122)65.9% (83/126)NS68.9% (171/248)[^1][^2]

The effect of season {#trx014s7a}
--------------------

In the dry season eosinophil counts (GMR 0.79 \[0.68--0.92\], p\<0.01) and platelet counts (GMR 0.93 \[0.87--1.00\], p=0.04) were significantly lower than the rainy season (Table [2](#trx014TB2){ref-type="table"}). Haemoglobin concentration (GMR 1.02 \[1.00--1.04\], p=0.05)is -9e4 + 3?
-9e1
In base 10, what is 20248 + -17?
20231
In base 6, what is -31 - 11144?
-11215
In base 6, what is 51 - -13441?
13532
In base 5, what is 124003 - -3220?
132223
In base 13, what is 1bb7 + -5?
1bb2
In base 13, what is -ba - -60?
-5a
In base 6, what is -5214 - -3?
-5211
In base 5, what is -24400 + 1014?
-23331
In base 2, what is 110101100010000 + -10?
110101100001110
In base 11, what is 2 - 3850?
-3849
In base 6, what is 155 - 2532?
-2333
In base 6, what is 4 - -415521?
415525
In base 16, what is 3 + -2ff81?
-2ff7e
In base 9, what is 1 - 5445?
-5444
In base 12, what is -3247b - -5?
-32476
In base 3, what is -12110122100 - 2?
-12110122102
In base 10, what is 2 + -9095?
-9093
In base 3, what is -2


-1212?
-121210011
In base 13, what is b568 - -20?
b588
In base 10, what is -4219 - 64?
-4283
In base 7, what is -11 + -646055?
-646066
In base 3, what is -2101100201 + -2120?
-2101110021
In base 10, what is -185761 + -5?
-185766
In base 16, what is -a4b93 + -4?
-a4b97
In base 9, what is 4 - -2548?
2553
In base 2, what is 0 + -11101010111100?
-11101010111100
In base 9, what is -1140 + -47?
-1187
In base 11, what is -482 - -80?
-402
In base 10, what is -241532 + -3?
-241535
In base 2, what is -100101 - 11100001001?
-11100101110
In base 5, what is -14333 - 12212?
-32100
In base 12, what is 9 + 6168?
6175
In base 11, what is -34 - -19548?
19514
In base 9, what is -114 + 2524?
2410
In base 16, what is -4 + 5c8f?
5c8b
In base 10, what is 25 + 549?
574
In baseshowed up in the document. I'm trying to figure out how to pull the full word if it has the character e I'm not sure what I need to do.
I'm trying to get the output to look like this
text
document
testing
...

A:

Instead of looking for each and every character in word using for loop, you can use in operator for searching through the words. For details about in keyword check this out.
You can try this (in python 3):
line = 'Press enter to Exit.'
for words in line.split(' '):
    if 'e' in words:
        print(words)

Output:
Press
enter

See Here ,Exit is not getting printed because we are only searching for 'e' But if you want 'E' also you can try if 'e' in words or 'E'


and risks of undergoing HBOT. HBOT was conducted at the Sagol Center for Hyperbaric Medicine and Research (Assaf Harofeh Medical Center). The treatment consisted of 1--3 daily sessions of 90 minutes of 100% oxygen at 2 atmospheres absolute with 5-minute air breaks at 20-minute intervals. As preoperative HBOT is still in the pilot stages, the number of treatment sessions has not yet been characterized and was at the discretion of the referring physician. The final HBOT session was conducted the day before surgery.

Data were collected from patients' medical records for preoperative medical history and postoperative records for the 6-month period following surgery. Primary outcomes were postoperative complications, including skin necrosis, infection, seroma, hematoma, wound dehiscence, or hypertrophic scarring.

Statistical Analysis
--------------------

Categorical variables were described as frequency and percentage. Continuous variablesis highlighted by the fact that patients in the HBOT group tended to have several risk factors for poor results and complications, that is, older age, smoking, and a previous abdominoplasty or liposuction. In addition, the benefit was retained when propensity score matching was performed to create matched pairs between the control and the HBOT groups.

Based on the beneficial effects of preoperative HBOT in our study, it could be argued that the use of preoperative HBOT preconditioning could potentially benefit patients undergoing several other surgical procedures. Although apparent costs are involved with HBOT preconditioning, including patient time investment and financial costs associated with the treatment, these might be easily offset by the potential benefits including a shorter hospital stay, lower overall costs, decreased morbidity related to complications, increased


and jurisdictional evidence suggest Estrada was injured as a contemporaneous result of the
firefighter's descent down the fire pole, rather than by a condition of the premises, we hold Estrada has alleged an actionable
"negligent activity" claim under the TTCA.  Accordingly, we affirm. (1)
Background
 Estrada was invited to visit San Antonio Fire Station No. 10 by an off-duty San Antonio firefighter in the early morning
hours of October 29, 2004.  Estrada, along with several other women, allegedly consumed alcohol and socialized with both
on-duty and off-duty firefighters at the fire station.  The firefighters allowed Estrada to: try on their firefighting gear; sit on
the fire truck; and slide down the station's fire pole, which allowed Estrada to go from the station's second floor to its first
floor. (2)
 After Estrada hadQ:

$( "#target" ).submit(); not working

For some reason I don't get why my form is not submitting using $( "#target" ).submit();.

<form id="frm" action="form.php" method="post">
    save
    <button type="submit" id="submit">Save</button>
</form>

A:

id  attribute cannot be submit in the form element try another name .
why we shouldn't set id as submit ?
because If a form control (such as a submit button) has a name or id of submit it will mask the form's submit method.


3(j)(2)(A):
DISCHARGE OF STUDENT LOANS  Kari Webber can not maintain based on current income and expenses, a minimum standard of living if forced to repay student loans. She has made *556 good faith efforts to repay the loans. State of affairs is likely to persist for a significant portion of the student loan repayment period. Upon successful completion of the chapter 13, the student loans will not be excepted from discharge.
The State of Alaska, by the Alaska Commission on Postsecondary Education, the Education Credit Management Corporation, and the United Student Aid Funds, Inc. filed objections to confirmation of the chapter 13 plan, and specifically objected to its attempt to discharge their student loan debts in the confirmation process. The Court heard those objections on July 12, 2000. Atrelying heavily on the fact that such plan provisions effectively shift the burden of going forward with the case for the hardship discharge. It held that the lending agencies should not be compelled to object to such plan provisions because they should be entitled to rely on the self-effectuating nature of § 523(a)(8), excepting such debts from discharge unless an adversary proceeding established the requisite undue hardship. 242 B.R. at 799. See also In re Hensley, 249 B.R. 318 (Bankr.W.D.Okla.2000); In re Fox, 249 B.R. 140 (Bankr.D.S.C.2000).
I concur that such student loan discharge provisions are not permissible in a chapter 13 plan or in an order confirming the plan. Bankruptcy Rule 7001(6) requires *558 an adversary proceeding to establish the dischargeability of such debts, and nothing in chapter


Q:

Are there a modules for temporarily backup and restore text files in Python

I need to modify a text file at runtime but restore its original state later (even if the computer crash).
My program runs in regular sessions. Once a session ended, the original state of that file can be changed, but the original state won't change at runtime.
There are several instances of this text file with the same name in several directories. My program runs in each directory (but not in parallel), but depending on the directory content's it does different things. The order of choosing a working directory like this is completely arbitrary.
Since the file's name is the same in each directory, it seems a good idea to store the backed up file in slightlywho cause widespread offence with their actions.”

To my mind, you don’t have a proud tradition of free speech if uttering insulting words could be a criminal act.

Apparently the Royals still enjoy an informal (?) pre-clearance power over some pending legislation:

The new laws that were required to receive the seal of approval from the Queen or Prince Charles cover issues from higher education and paternity pay to identity cards and child maintenance.

In one instance the Queen completely vetoed the Military Actions Against Iraq Bill in 1999, a private member’s bill that sought to transfer the power to authorise military strikes against Iraq from the monarch to parliament.

A constitutional lawyer quoted in the Guardian article referred to this as the Royals’ “nuclear deterrent”. I know, constitutionally, that the Queen could


was merely pointing out that, for English folk, this is and has long been an inexplicably barbarous conflict perpetuated by groups of arseholes on both sides, none of whom most of us are really interested in sharing a country with. So since, they actually live in a different country we wouldn’t mind if they all fucked off and stopped demanding to stay part of this one.

I addressed the issue. If you don’t think the UK flag should fly over Northern Ireland there is currently a procedure for the majority of the population to vote to join the ROI and fly the Irish flag over government buildings. They have not yet done so. When I talked to the Irish ambassador to Estonia in 2005 he said that the ROIbelow .

As well as this, almost all of the human icons (including occupations) have been tweaked. Some examples are shown below, including a much less sinister 🕵 Detective and David Bowie-inspired 👨🎤 Man Singer and 👩🎤 Woman Singer icons.

In regards the non-human characters, there are several noteworthy changes. Firstly, all of the cat faces are now a yellowish colour and have black cartoon eyes as opposed to their previous grey fur and blue eyes combo. 😺 Grinning Cat Face is shown as an example below.

And the ever-popular 💩 Pile of Poo now has a smiling mouth to go alongside its eyes (although its eyebrows have vanished)!

Making quite the dramatic change, the 👿 Imp face has lost its impishness and been converted into the norm: a displeased version of


🐺 Wolf Face have been updated.

The versions of ⛹ Person Bouncing Ball is now actually bouncing their basketball, akin to other vendors.

📿 Prayer Beads no longer feature a crucifix, again akin to other vendors.

The 📛 Name Badge, which in the last Samsung emoji update received three letters assumed to be initials in its central white strip, now has had those same letters removed. Similarly, initials have been removed from 📓 Notebook, 📒 Ledger and 🏷 Label in their re-designs.

🎌 Crossed Flags, 🗾 Map of Japan and 💹 Chart Increasing With Yen have each received graphic revisions, though their continued inclusion in Samsung's emoji set is of note in and of itself.

The various moon phases, such as 🌒 Waxing Crescent Moon and 🌔 Waxing Gibbous Moon, have also hadsecondary antibody (Molecular Probes). Negative controls were labelled with secondary antibodies only. Specimens were examined using a BioRad MRC 1024 Confocal Microscope. To ensure specificity of staining, images were obtained using confocal machine settings at which no fluorescence was detectable in negative control samples. Specimens were serially excited at 488 nm and observed at 505\~550 nm to detect Alexa 488, then excited at 568 nm and observed at 585 nm to detect Alexa 568.

In vivo tumorigenesis assay in NUDE mice
----------------------------------------

The mice were handled under a unidirectional laminar airflow hood. Non-infected hMSC and MDAMB-231 (breast cancer) cells were used as negative control and positive control, respectively, for tumour formation. The hMSC were grown in non-inductive medium, infected with Ad-hTERT and then subjected to osteogenic differentiation for 14 days. The


clubhouse preparing to make a road trip, and didn’t stop until the team had made their way cross-country to the West Coast—polishing off 64 cold ones. According to alleged sources, he sucked down Miller Lite exclusively, so the fact that he hasn’t ended up in one of their commercials is almost as amazing as the fact that he hasn’t ended up in the ER with alcohol poisoning. Everyone says the same thing, “64 beers…that’s fucking impossible.” Maybe for mere mortals, but Boggs’ ex-teammates have time and again confirmed that he could drink like nothing they’d ever seen, and that this wasn’t a one time occurrence.

Obviously it wouldn’t be the greatest PR move, even for a retired athlete, to confirm a drinking binge of this magnitude. However, the only= selectedZonesList;

        try
        {
            if (ModelState.IsValid)
            {
                FeeScheme_UOF.CreateFeeScheme(newSchemeData);
            }
        }
        catch (DataException ex)
        {
            ModelState.AddModelError("", "Unable To Create New FeeScheme!" + ex);
        }


R5 Rock WE Day in Toronto

Joe Jonas was one of the many celebrities on hand for WE Day in Toronto on Thursday afternoon. One of the acts taking the stage to rock out for the crowd was R5

The group took the stage to perform their current single “Heart Made Up On You.” Afterwards, Rydel tweeted, “So glad to have been apart of #WeDay today. The kids are soooooo inspiring.” The band account added, “So excited to be here today with all the kids making a difference in the world.”

Watch R5’s performance below. If you missed their live chat with SiriusXM yesterday, watch that below too.

Lisa is the founder & executive producer of Shine On Media. A self-proclaimed lover of all things nerdy, you'll usually catch her at the7 Crucial Questions to Ask Before Choosing a Seller’s Agent

Your home is likely the largest financial investment you have, so it makes sense to carefully choose the right agent to represent you when you sell it. The best real estate agent will walk you through the whole process, showcase your home in the best light, give you feedback from showings and open houses, and let you know whether you should accept a buyer’s offer up front or negotiate for a higher price.

It’s a good idea to talk to more than one listing agent before you sign on with one. As you’re interview listing agents, ask these questions so you can determine which agent will best help you sell quickly and for the most money possible.

1. What’s Your Real


I wanted to hide." "You know why I'm here?" "Sphere." "Yeah." "I'm letting you go." "Get out of here." "Go!" "Move it!" "Crichton," "I found'im." "Meet me in the maintenance bay." "On my way." "Where is he?" "I let him go." "I thought you would." "John, you had your chance." "And you blew it." "You let your emotions get the better of ya." "You couldn't face reality." "You wanna face... reality?" "Face reality?" "We were saving ourselves at someone else's expense!" "Who wasn't worth saving." "Come on, Johnny." "Don't tell me you didn't think that." "I can see a part of you still thinks it." "Remember the way you first saw the ape man?" "How you could legitimize sacrificing him?" "Well guess what?" "That's the way I seebe lizard people living on Mars right now if you did anything else (like stop Trump from being born). Oh wait, I could so rock a suit of scales AND I hear tell it’s warm and sunny on Mars today. Yeah babe, go for it!

7) Should I be afraid of the increase in the number of times a certain word escapes me? Honestly, that isn’t as troubling as the number of times I am asking myself “Did I take a shower already? I showered, right?”
Damn, I’ve got this same question (not the shower part – I know I showered today).

8) Why did anyone think purple ketchup was a good idea?
Dunno but it’s a nice color….on jelly.

9) Shouldn’t there be an international “Alan Rickman” day?
YES!

10) Do I have an


Q:

Is there a connection between Sith and Naboo?

I've recently seen some stuff written about a connection between Naboo and the Sith.
Overall, the guy said that Naboo has a lot of Sith history. In particular, here are some of the things he wrote:

Exar Kun is a very distant relative of Padme Amidala
Jedi are hated in Naboo
Naboo has long history with the Sith, it belonged to the ancient Sith Empire
The dark side is strong on Naboo, especially near plasma mines
One of the conditions with which Naboo joined the republic - the Jedi should not descend to the planet

I've read couple of books from expanded lore, but I am by no means an expert in the canon/legends.
This stuff seems a bit weird. I haven't seen anything about this mentioned in theBackground {#Sec1}
==========

Postprandial hyperglycemia contributes to the development of cardiovascular diseases and type 2 diabetes \[[@CR1], [@CR2]\]; both diseases lay burden on the healthcare systems, globally \[[@CR3]\]. Postprandial hyperglycemia is a condition that can be improved through lifestyle and diet modifications. In functional food research, dietary polyphenols have shown potential to improve the postprandial glucose and insulin responses and promote well-being via several postulated underlying mechanisms: 1) inhibition of carbohydrate digestion and the subsequent glucose absorption, 2) stimulation of insulin secretion from pancreatic β-cells, 3) modulation of hepatic glucose output, 4) activation of insulin receptors and glucose uptake in insulin-sensitive tissues, and 5) modulation of intracellular signaling pathways and gene expression \[[@CR4]--[@CR6]\].

Fruits, berries, vegetables, tea and coffee are the common sources of dietary polyphenols \[[@CR7]\]. Decreased postprandial blood glucose


centrifuged for 10 min. The supernatant was then filtrated through Teflon filter (0.2 μm) (VWR International, West Chester, PA, USA) prior to the analysis without further clean up.

Analysis of phenolic compounds during shelf life {#Sec8}
------------------------------------------------

Batch and inter-day variations were investigated for the five test products when stored in unopened packages at + 4 °C. Two different batches of the four test products (Bilberry, Blackcurrant, Mango and Rose hip) were analyzed during the study time. The first batch was analyzed on the first day of the intervention and 4 weeks later (shelf life). The second batch was analyzed in the week 5 and 6 (completion of the study). Three batches were analyzed for Beetroot. The first batch was analyzed on the first day of the intervention and 2 weeks later (shelf life). The second batch2 μl and the vial tray was held at 4 °C. Three wavelengths 280 nm, 350 nm and 520 nm were selected for identification of phenolic acids, flavonols and anthocyanins/betalains, respectively.

Total phenolic content {#Sec9}
----------------------

The total phenolic content of the test products was determined by the Folin-Ciocalteu (FC) assay \[[@CR17]\]. The volume of the reaction mixture was miniaturized to 1 ml. 10 μl of sample were mixed, to which 50 μl of undiluted Folin-Ciocalteu reagent was subsequently added. After 1 min, 150 μl of 2% (*w*/*v*) Na~2~CO~3~ and 790 μl of water were added. After 2 h of incubation at 25 °C, 300 μl of the mixture was transferred into a well of the microplate, the absorbance was measured at 760 nm in a microplate spectrophotometer reader (Multiskan GO, Thermo Fisher, Germering, Germany) and compared to a gallic acid calibration curve (0.025--2.000 mg/ml) elaborated in


the study. Thus the study is based on eleven participants.

Viable count {#Sec13}
------------

The lactobacilli counts in the five probiotic drinks were stable during the storage period, and between the different batches (3--5 × 10^7^ CFU/ml).

Glycemic response {#Sec14}
-----------------

The incremental blood glucose response after intake of the Bilberry, Blackcurrant, Beetroot, Mango, Rose hip products and the reference glucose drink are shown in Fig. [1](#Fig1){ref-type="fig"}. No significant differences regarding the incremental blood glucose concentrations were found between the groups at any of the time points, and the same was true for the glycemic responses measured by IAUCs (Table [1](#Tab1){ref-type="table"}).Fig. 1Incremental blood glucose response curve during the two-hour postprandial period. The change in blood glucose concentration was calculated by deducting the basal level from the blood glucose level measured after intake of the test drinks and was representedthat do not share the same letter are significantly different. ^\#^Before *P* value adjustment *P* = 0.034, after adjustment *P* = 0.062

Polyphenol profiles {#Sec17}
-------------------

The analysis of phenolics (Table [4](#Tab4){ref-type="table"}) showed that the highest values of the total phenolic compounds (280 nm) and flavonols (350 nm) were found in Bilberry whereas Mango had the lowest. The highest values of total anthocyanins/betalains (520 nm) were found in Bilberry and Beetroot, while these families of polyphenols were not detected in either mango or rose hip. Chromatograms corresponding to the HPLC-DAD analysis of the five test products are presented in supplementary figures (see Additional file [1](#MOESM1){ref-type="media"}: Figure S1 to S5). Regarding the analysis of the total phenolic measured by FC assay and total antioxidant capacity measured by DPPH and TEAC assays (Table [5](#Tab5){ref-type="table"}), Rose hip beverage was the one with the highest phenolic


samples. Grey dashed line shows 1.04376\*(±2SD) and the black dashed line 1.04376\*(±3SD)Fig. 4Orthogonal projections to latent structures discriminant analysis (OPLS-DA) model calculated on polyphenol profiles and discriminating between Bilberry and Rose hip (Bil_Rose class) and other tested beverages (described response variation, R^2^Y = 0.977; predicted response variation, Q^2^Y = 0.973). The difference between the two classes of berries was explained by 31.6% of the variation in polyphenol data. **a** Score scatter plot. **b** Loadings bar plot showing the driving forces for the observed cluster separation. The Bil_Rose class had higher levels of phenolics as compared to the other berries

Discussion {#Sec19}
==========

Consumption of the polyphenol rich probiotic fruit and vegetable beverages did not affect postprandial glycemic responses, but the four fruit drinks supplemented with bilberry, blackcurrant, mango and rose hip significantly attenuated the insulinHPLC-DAD analysis of Mango beverage at 280 nm, 350 nm and 520 nm. P, phenolic compounds; and F, flavonols. **Figure S5.** Chromatograms corresponding to the HPLC-DAD analysis of beetroot beverage at 280 nm, 350 nm and 520 nm. P, phenolic compounds; F, flavonols; and B, betalains. (DOCX 2460 kb) Additional file 2:**Figure S6.** PCA score plot of data from phenolic analysis of the five tested drinks. PC1 and PC2 explained 60.4 and 25.2% of the variance in the data respectively. (PDF 49 kb)

**Electronic supplementary material**

The online version of this article (10.1186/s12937-018-0335-0) contains supplementary material, which is available to authorized users.

We thank the clinical trial unit at Skåne Univeristy Hospital for their assistance with collecting samples and Ms. Eleonor Gautier for her enthusiastic support with statistical analyses as part of her internship at ProViva AB. We also


(released 1 Mar 2013)

Pick style A/S-type dicitonary items can now use the CALL processing code in the correlative expression (field 8).

The output from the CONFIG command now marks those parameters that have been set in the qmconfig file or modified in the current QM session. Unmarked parameters take their default values.

The FIND.FILE command reports summary information about a file, including details of the cause if a file cannot be opened.

QMBasic includes an experimental development to support the concept of TRY/CATCH exception handling as found in many other programming languages.

QM 3.0-6 (released 14 Feb 2013)

This release introduces support for IPV6 network addresses in all networking elements of QM, including direct entry to QM via telnet, the QMBasic socket operations and QMNet. IPV6 support must be enabled via the IPV6films
Category:1955 horror films
Category:American films
Category:American science fiction horror films
Category:English-language films
Category:American black-and-white films
Category:Films shot in California
Category:Films directed by Roger Corman
Category:Alien invasions in films


Article content continued

Nadler and the other chairmen made clear they believe Trump did obstruct justice, according to people on the call. McGahn would be a star witness for any such case because he refused Trump’s demand to set Mueller’s firing in motion, according to the report.

“The Special Counsel’s report, even in redacted form, outlines substantial evidence that President Trump engaged in obstruction and other abuses,” Nadler said in a statement released as the conference call got underway. “It now falls to Congress to determine for itself the full scope of the misconduct and to decide what steps to take in the exercise of our duties of oversight, legislation and constitutional accountability.”

The subpoena angered Republicans even as it functioned as a reassurance to impatient Democrats.

Rep. Doug Collins of Georgia,Robotic lawn mowers are gaining popularity—more and more people are discovering the charm of not having to move their lawn manually or with a powered lawn mower. Moreover, the robotic lawn mowers are usually powered by electricity from the electric grid, meaning that pollutants from engine powered lawn mowers are avoided.
Usually, robotic lawn mower are chargeable electric devices comprising two individually powered drive wheels, a mowing means, sensors to detect a work space boundary and means for allowing the robotic lawn mower to find its way to the charger.
When in operation, a robotic lawn mower will run back and forth over the working area, which is delimited by a boundary wire buried shallowly near the working area, through which wire an electric current having a specific signature is


fed. The electric current fed through the wire will create a magnetic field. The sensors of the robotic lawn mower will notify a controller of the robotic law mower when the robotic lawn mower approaches a boundary wire, and at a predetermined position of the robotic mower vis-à-vis the boundary wire, the robotic mower will back away slightly perform a predetermined turn and continue in the forward direction away from the boundary wire.
In most robotic mowers, the turn is effected by rotating the drive wheels of the robotic mower in opposite directions such that the robotic mower turns around a vertical axis extending through the robotic mower between the drive wheels. The other wheel pair is usually hinged in order to allow for it to move in anyLindblom, RHP- So far, all the 2010 top prospects have regressed. Lindblom bounced between starter and reliever. Now he's strictly a reliever. Perhaps he can get back on track and be a serviceable guy out of the 'pen. He got rocked at Albuquerque.

5. Aaron Miller, LHP- Miller had a rough showing in Double-A, but was solid in High-A. The 2011 season will determine whether or not he returns to elite prospect status.

7. Ivan DeJesus, 2B- DeJesus played a full season at Triple-A after missing all but four games in 2009. He's the closest Dodger prospect to the majors, but still has question marks.

8. Nathan Eovaldi, RHP- Eovaldi couldn't stay healthy and has yet to develop a consistent third pitch. He looks like he's ticketed for bullpen duty, which


my 2011 rankings (or keep him in the top 30).

24. Justin Miller, RHP- Miller is a groundball pitcher and threw 77 good innings in 2010. He does need to cut down on the walks. He could get a look in the Dodger 'pen if there are injuries.

25. Austin Gallagher, 3B/1B- After a promising showing at High-A in 2008, Gallagher hasn't progressed and hasn't made it past High-A. His 2010 was better than his 2009, but still not promising overall.

26. Brett Wallach, RHP- He was traded along with Blake DeWitt to the Chicago Cubs for Ted Lilly and Ryan Theriot at the July 31 trade deadline. He threw much better at Great Lakes for the Dodgers than he did at Peoria for the Cubs.

27. Luke May, C- He wasIn this brief study, I examine the many numbers cited by the Israeli military relating to Gaza rocket attacks into Israel.

To begin, Israeli spokespeople frequently remind the world that a million Israeli citizens are within range of Gaza rockets, twelve thousand of which have been fired into Israel in the last twelve years, inflicting thousands of injuries and several dead.

However, we are rarely told exactly how many people have been killed by these rocket attacks.

Counting the dead

Below is a list of all the fatalities of rocket and mortar attacks fired from the Gaza Strip into Israel in the entire history of these attacks. Throughout the years of rocket attacks into Israel, a total of 26 people have been killed altogether.

Fatalities from rocket and mortar attacks in Israel from


soon as Israel launched Operation Cast Lead, four more people were killed by Gaza rockets and mortars. Yet the IDF graphic claims 15 fatalities. Again, this claim is contradicted by the Shin Bet, which reported that in 2008,

8 people (4 during the final days of December) were killed by high-trajectory fire (rockets and mortars) from the Gaza Strip.

For 2008, it is unknown how the IDF transformed eight fatalities into fifteen.

2009

In 2009, there was one conflict-related civilian death in Israel by Palestinians: A Jewish Israeli taxi driver was strangled to death by three Palestinians as revenge for the IDF killing of a relative. Outside of that, a 16-year old boy in the Bat Ayin settlement was killed by a lone Palestinian with an axe, two police officers were shotsettlements, including a soldier killed while on his way to guard duty in Kfar Darom and a soldier killed at an IDF outpost in the Morag settlement.

All other rocket and mortar fatalities within Gaza were directed against IDF soldiers engaged in military operations outside of settlements.

3. One fatality in Israel by anti-tank missile. The rockets-and-mortars rhetoric refers to high-trajectory ordnances deployed with the following qualities: indirect fire, which coupled with a high inaccuracy rate results in nondiscriminatory targeting; a wide range that encompasses significant portions of southern Israel; and a high deployment frequency.

Anti-tank missiles are direct-fire ordnances with a more limited range and have been used infrequently against civilian targets by Gazan armed groups. There has been one civilian fatality from an anti-tank missile fired from the Gaza


on the profound interplay between transplanted MSCs and recipient components that mediates and modulates therapeutic effects on skeletal conditions. Accordingly, novel solutions have recently been developed, including improving resistance of MSCs to diseased microenvironments, recreating beneficial microenvironments to guarantee MSC-based regeneration, and usage of subcellular vesicles of MSCs in cell-free therapies. In this review, we summarize state-of-the-art knowledge regarding applications and challenges of MSC-mediated bone healing, further offering principles and effective strategies to optimize MSC-based bone regeneration in aging and diseases.Oneida® Allude 45-Piece Flatware Service for 8 Plus Hostess Set

This beautiful 45-piece stainless steel flatware set will make a stunning statement on any table. Allude's delicate design can be compared to the movement silk of the wind. This pattern flows across the surface making each piece unique yet unified.

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Oneida's Degree 5-Piece Hostess Set has a chic, contemporary design that works well with casual and more formal patterns. Beautifully crafted in 18/10 stainless steel with a bright mirror finish, these elegant serving pieces are also dishwasher safe.

With a pattern that was created exclusively for Bed Bath & Beyond, Oneida's Downing 65-Piece Flatware Set features a brushed finish and sleek design that fits comfortably in your hand. Made from 18/10 stainless steel.

Teardrop shape tips, edged with a traditional beaded


a 37 gal I'm good with one 2 liter for a month. My plants doubled in size in 2 weeks when I started with DIY co2. I use 1 cup of brown sugar with 1 cup of white sugar. I use really warm water until the sugar is dissolved, then when the sugar is dissolved I take a cup of the sugar water and mix in the yeast while its still warm. This activates the yeast quicker. Then comes the baking soda, pour it all in to a 2 liter bottle and shake. I usually get bubbles in 45-60 minutes. Good luck!

It's all the same you should be good with the standard mix. 2 cups sugar 1/2 tsp yeast 1 tsp baking soda. I have a 37 galwomen who have chosen to run for the presidency of the United States and who the men across this country could not care less about because there are sixteen boring ass dudes running for the same office. Now, no man even bothers to send me a gross Instagram DM or booty call me in the middle of the night or do even an ounce of research into the frankly very attainable and plain-language bill I’ve drafted to overhaul the US public education system. I have finally found peace. I am finally free!

The future is female! And entirely invisible!


I want to take it. My ambition to become a writer has grown exponentially, becoming less of a goal and strangely more of a calling. The prospect of developing my knowledge in literature and expanding my own writing style through university is making me unbelievably excited. If I could only find the words to describe this feeling of almost matured boyish wonder I could write for hours. For now, however, I still have the stories of this past month to recollect and the future will have its time.

Also, this post will undoubtedly be very long, so sorry for that too.

The first few days after our arrival in Pokhara was what I think of as the exploration of Lakeside. Firstly and most importantly, food. So actually it should beknown as the exploration of cafes restaurants and everything edible. We were eating and drinking what ever our hearts desired and it was glorious. Interestingly in Bobang Sam and I could talk for hours about all the delicious food that awaits us back in the UK, but when we have the food in front of us all we seem to talk about is all the interesting food we could make in Bobang again! Anyway so once our cravings were dealt with we had time to explore lakeside during the day and appreciate lakeside during the night, which was made easier accompanied by an occasional night time beverage, of course.

At our hotel I met an interesting Swedish pensioner, who I nicknamed the prophet in my head for his insightful


too. My fingers were slow and numb, my nose red and ticklish, my legs painful and heavy. They all deserve credit but really it was my eyes that carried me up there, the longing for that view and the bragging rights that come with it. I was literally in amongst the Himalayas, a place that when I was kid may as well have been Hogwarts, a place I’d always hoped to see but I never thought I would. I felt absolutely invincible, and this feeling was oil on the fire of my motivation for later life. I want to be a writer, and that’s what I’m going to be. I love to travel, and that’s what I’m going to do.

After filling up on some Veg fried rice andfollowers of infiltrating state institutions, has said the sackings were necessary to remove what he called the "virus" of Gulen's influence from state bodies.

Critics accuse the government of using state of emergency legislation to target its opponents, including opposition journalists and pro-Kurdish critics.

The co-leader of the main pro-Kurdish opposition Peoples' Democratic Party, Selahattin Demirtas, is among those detained on terrorism charges, something he denies.

- Uniforms for suspects -

The decree on dismissals was published alongside another announcement that men accused of "acting against the constitutional order" would have to wear a single colour uniform, either brown or grey, during court hearings.

The uniform will also apply to those accused of attempting to abolish the Turkish government and will come into force next month.

Erdogan previously said that alleged coup-plotters would wear


food selection and plate waste by a research team using a standardised procedure. Reference dishes from the dining facility with known weights of individual foods within the meals can be used to estimate the weights of participants\' individual food intake. In an earlier study assessing food intake in worksite canteens, we showed that estimation error is reduced by weighing the dishes before and after eating and hereby obtain an estimate of total weight of food eaten (not published).

With regard to assessing the food intake of free-living individuals, several issues complicate the usability of the digital method. First, it is not possible to take images of reference dishes directly related to the food eaten. Instead a database with reference images of commonly eaten foods can be applied but thisvegetable category limits of agreement when expressed as g per 10 MJ was from −241 to 236, whereas the antilog transformed limits of agreement in g were from −85 to 36% (not shown). An almost similar range of agreement limits were found for the meat category (−32 to 85%), whereas ranges were a little wider for the fat and sauce category (−37 to 108%) and slightly narrower for the starchy category (−29 to 74%; not shown).

The capacity of the digital method to classify weights within the same quartile or adjacent quartile for each food category is shown in [Tables 2](#T0002){ref-type="table"} and [3](#T0003){ref-type="table"}. The proportion of food categories classified into the same quartile ranged from 56 to 78% (expressed as g/10 MJ). With regard to energy content and macronutrient


/*
 * Copyright (c) 1996, 2011, Oracle and/or its affiliates. All rights reserved.
 * DO NOT ALTER OR REMOVE COPYRIGHT NOTICES OR THIS FILE HEADER.
 *
 * This code is free software; you can redistribute it and/or modify it
 * under the terms of the GNU General Public License version 2 only, as
 * published by the Free Software Foundation.  Oracle designates this
 * particular file as subject to the "Classpath" exception as provided
 * by Oracle in the LICENSE file that accompanied this code.
 *
 * This code is distributed in the hope that it will be useful, but WITHOUT
 * ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or
 * FITNESS FOR A PARTICULAR PURPOSE.  See the GNU General Public License
 * versionif (System.getSecurityManager() == null) {
            SunEntries.putEntries(this);
        } else {
            // use LinkedHashMap to preserve the order of the PRNGs
            Map<Object, Object> map = new LinkedHashMap<>();
            SunEntries.putEntries(map);
            AccessController.doPrivileged(new PutAllAction(this, map));
        }
    }

}


lets make them .f1167 .f1168 and so on. can we have the jquery add an "f" in front of the option value to make it the class name?

A:

The jQuery addClass method has an overloaded method which accepts a function as a parameter. You can leverage that to set the class for all of the elements at once:
$(function() {
    $('select[name="SELECT___ENG_SVC___52"] option').addClass(function() {
        return 'f' + $(this).val();
    });
});

altitudes, but you cannot grow it in places that freeze, “so you need that mixture of high altitude and warm climate, which makes the tropics the place to grow it.”

All across Latin America, Africa and Southeast Asia, people grow coffee.

In many tropical countries, especially poor ones, it’s a pillar of the economy; exports of green coffee beans, globally, are worth $15 billion a year.

Some of these farms, Ionescu says, are idyllic places, high in the mountains. Taller trees often shade the coffee bushes. Such scenes “hearken a little bit to coffee’s homeland, which is Ethiopia,” Ionescu says. “Southwestern Ethiopia is really lush, it’s got amazingly high altitudes, it’s green, misty.”

But honestly, even though there are millions of small, idyllic coffee farms, they aren’t producing the majority of the


Local and European elections, Fine Gael
has fallen.

They are receiving plaudits for their inability to present a viable
alternative candidate, for their incapacity to run a Presidential election
campaign and their cowardice in not challenging a President still widely
perceived as a Fianna Fáil candidate despite her newly acquired Independent
tag. It is hardly the sign of the Blueshirt rejuvenation so loudly trumpeted
in June. What kind of opposition party leans heavily on its own councillors
to prevent Dana appearing on the ballot paper?

Meanwhile, the Greens have spent a week confirming their reputation for the
bungling amateurism that characterised their inept summer election campaign.
Barely had Eamon Ryan declared his candidacy on RTE Radio before a Green TD,
widely assumed to be John Gormley, was ringing Charlie Bird to disassociate
the party from the proposal.

Leading Green Party figures likeis below the coercive field of the ML we observe that the SC still exhibits a decrease below its $T_c^{SC}$. When the external field exceeds the coercive field of the ML the SC reverses its magnetization exhibiting an [*increase*]{} below its $T_c^{SC}$.

Detailed $m(T)$ data revealing the reversal of the SC’s magnetization near the coercive field of the ML are presented in Figs.\[b3\](a)-(d) for an AF/FM-Nb sample. Panels (a) and (c) show the increasing and decreasing $m(H)$ branches, respectively, constructed from the $m(T=10$ K$)$ data, while panels (b) and (d) show the respective $m(T)$ curves. In the data presented in panels (a)-(b) the sample was initially UBS and was set to negative saturation (the UBNS acronym in Fig.\[b3\](b) refers to initial negative saturation). Then the field was lowered to


respective $m(T)$ curves. The relative configurations of the ML’s and SC’s magnetizations in respect to the external magnetic field $H_{ex}$ are shown in both cases. Panels (c) and (d) present the respective data for UBS and BS initial conditions. []{data-label="b3"}](fig3b.eps "fig:"){width="9cm"}

All these purely experimental data point to the situation which is presented by the respective schemes of Figs.\[b2\](a) and \[b3\](a). We see that in all cases the magnetization of the SC is aligned parallel to the one of the ML as if the Nb layer is simply an extra layer coupled ferromagnetically to the rest FM layers through the adjacent AF ones. [*Macroscopically, the interpretation of the obtained results seems to relate to the stray fields that the SC experiences.*]{} The total stray fields of both the FMnot actually affected when we reverse the external magnetic field and only switches together with the magnetization of the ML when its coercive field is exceeded. The exchange biasing mechanism offered by the ML affects the behaviour of the whole hybrid; the magnetic field’s value where the switching of the SC occurs may be regulated by selectively biasing the ML or not. Macroscopically, our findings may be explained by suggesting that the stray fields of both the FM buffer’s and the ML’s may efficiently modulate the effective magnetic field experienced by the SC. Microscopically, our results may be explained by assuming the formation of spin-triplet superconductivity. The ML structure is needed for the occurrence of the discussed effects since simple FM-SC bilayers don’t exhibit the same behaviour. In


IN THE COURT OF CRIMINAL APPEALS

OF TEXAS

NOS. PD-0906-09, PD-0907-09, PD-0908-09, and PD-0909-09

EDUARDO VALTIERRA & HERIBERTO VALTIERRA, Appellants

v.

THE STATE OF TEXAS

ON STATE'S PETITION FOR DISCRETIONARY REVIEW
FROM THE FOURTH COURT OF APPEALS

KENDALL COUNTY

 Cochran, J., delivered the opinion of the unanimous Court.

OPINION

	This appeal concerns the scope of a consent to search under the Fourth Amendment.
Both the trial court and the court of appeals agreed that Heriberto Valtierra consented to have
police officers enter his apartment to talk to Erica, a 13-year-old runaway.  The question
before us is whether, viewed in the light most favorable to the trial court's ruling, the
evidence is sufficient to show that the scope of Heriberto's consent extended to the officer's
act of walking down the open hallway to knock on the bathroom door where Erica was said
toJimeno, (38) the Supreme Court explained that "[t]he scope of a search is
generally defined by its expressed object." (39)  In that case, Mr. Jimeno gave the investigating
officer permission to search his car, knowing that the officer was looking for drugs, and he
"did not place any explicit limitation on the scope of the search." (40)  Thus, it was "objectively
reasonable for the police to conclude that the general consent to search [Jimeno's] car
included consent to search containers within that car which might bear drugs." (41)  The
Supreme Court carefully noted that a person may expressly limit the scope of his consent to
search, "[b]ut if his consent would reasonably be understood to extend to a particular
container, the Fourth Amendment provides no grounds for requiring a more explicit
authorization." (42)


 That finding does
not end the Fourth Amendment inquiry, however, because the entry into the bedroom and the
discovery of drug paraphernalia depend upon the legitimacy of the "protective sweep" that
Officer Rutledge made after Officer Moncada saw the two men making "furtive gestures." (52)
Although the court of appeals was correct in concluding that a "protective sweep" did not
provide the basis for Officer Moncada's walk down the hallway, it has not examined the
Fourth Amendment reasonableness of the officers' actions after Officer Moncada saw the
furtive gestures.
	We therefore reverse the judgments of the court of appeals and remand these cases to
that court for further proceedings consistent with this opinion.

Delivered: May 5, 2010
Publish
1.  Eduardo Valtierra v. State, 293 S.W.3d 725 (Tex. App.--San Antonio 2009); and
Heriberto Valtierra v. State, 293of consent is determined according to the 'totality of all the circumstances.'")
(quoting United States v. Torres, 32 F.3d 225, 230-31 (7th Cir. 1994)).
49.  See State v. Garcia-Cantu, 253 S.W.3d 236, 241 (Tex. Crim. App. 2008) ("[T]he party
that prevailed in the trial court is afforded the strongest legitimate view of the evidence and all
reasonable inferences that may be drawn from that evidence.").
50.  Jimeno, 500 U.S. at 251; see United States v. Ibarra, 965 F.2d 1354, 1357 (5th Cir.
1992) (under Jimeno, "the question of objective reasonableness is a question of law, [but] the
factual circumstances surrounding the consent are central to determining the nature of the
consent and how it would have been understood by a reasonable person.").
51.  See Jimeno, 500 U.S. at 251; see also United States v.


achieved using only the BAO survey from . This is to be compared with Fig. 54 in @ReviewDoc, whose forecast was for (with the specifications foreseen at the time) plus a Stage IV (SNAP-like) SnIa mission: the achieved constraints are compatible with what we find here. In summary, $\epsilon_0$ and $\epsilon_1$ are now constrained with an error smaller than $10^{-2}$, improving the sensitivity of current constraints by about a factor of $\approx6$. Notice that here we are not considering one of the two primary probes of , i.e. cosmic shear. Adding the information brought by such a probe would further constrain the value of $\Omega_{\rm m,0}$, thus resulting in even tighter bounds on the DDR parameters $\epsilon_0$ and $\epsilon_1$.

As can be seen in the addition of DESI toIn fabricating semiconductor devices, packaging is a process to protect the semiconductor chips from an external environment, to shape a semiconductor chip for an easy application, and to protect the operation functions added in the semiconductor chip and thus enhance the reliability of the semiconductor device.
Recently, as the semiconductor devices are highly integrated and their functions become versatile, the packaging is gradually transferred from a process having a small number of package pins to a process having a large number of package pins, and is also converted from a structure where a package is inserted into a printed circuit board (PCB) to a structure where a package is mounted on a surface of a PCB, i.e., surface mounting device structure. Examples of the surface mounting type packages include


and modulate their function ([@B1]). Alternatively, the presence of Sus1 in both complexes may be coincidental, and this protein may have mechanistically separate roles in SAGA and TREX-2. Other proteins may also be important in linking the two complexes and, for example, deletion of the SAGA component Sgf73 alters the association of Sus1 with the TREX-2 complex ([@B24], [@B30]). Sgf73 also plays a role in recruiting Sac3 and Thp1 to SAGA, and it has been suggested that Sgf73 may alter the TREX-2 component Sac3 allowing for efficient TREX-2 assembly ([@B24]). Distinguishing between these different putative functions of Sgf11 and Sus1 has been difficult because it was not known how Sus1 binds to Sgf11 ([@B11], [@B32]). Extensive mutagenesis studies of Sus1 showed that, although it was possible to generate                          13.9 (7.2)            22.4 (22.6)
      *R*~pim~ (%)[^*a*^](#TF1-1){ref-type="table-fn"}               1.5 (29.2)            2.4 (29.7)
      *R*~merge~ (%)[^*a*^](#TF1-1){ref-type="table-fn"}             5.9 (75.7)            11.2 (138.6)
      Mean *I*/σ(*I*)[^*a*^](#TF1-1){ref-type="table-fn"}            26.2 (2.4)


the principal interactions between Sus1 (*blue*) and Sgf11 (*yellow*), which are somewhat different to those observed between Sus1 (*blue*) and Sac3 (*red*) (*E*, see Ref. [@B10]).](zbc0091005330002){#F2}

![*A* and *B*, helical nets showing the hydrophobic stripe on Sac3 to which Sus1 binds (*A*; see Ref. [@B10]) and comparing it with the stripe on Sgf11 (*B*). The Sus1-interaction interface on Sgf11 is clearly less extensive than that seen on Sac3. Charged residues are *red* (positive) and *blue* (negative). *C*, the hydrophobic stripe on *Saccharomyces cerevisiae* Sgf11 is generated by an ∼four-residue sequence repeat of hydrophobic side chains. Similar four-residue sequence repeat motifs were present in Sgf11 from *K. lactis* and *C. albicans*.](zbc0091005330003){#F3}

There was a striking variation in the position of Sus1 helix α1 between Sgf11-Sus1 complexes within and between crystals ([Fig.substituting charged for hydrophobic residues, would increase the likelihood of introducing major conformational changes. In analogous studies on the binding of calmodulin to helical peptides, Ala substitutions sometimes even enhanced affinity ([@B39]). We therefore used an alternative strategy to disrupt the interaction, based on inserting an Ala residue in the Sgf11 helix, so that the hydrophobic stripe to which Sus1 binds was disrupted. As illustrated in [Fig. 5](#F5){ref-type="fig"}, *A* and *B*, insertion of a single residue in an α-helix results in a rotation of ∼100°. Insertion of a single Ala after Sgf11 residues 18 or 19 (*lanes 19A* and *20A* in [Fig. 5](#F5){ref-type="fig"}*C*) resulted in a dramatic decrease in the affinity of Sgf11 for Sus1 in *in vitro* pulldown assays ([Fig. 5](#F5){ref-type="fig"}*C*). The effectiveness of this mutagenic approach


synthesis blocker (quinolones, nitroimidazoles, and rifampicin), and (v) folic acid synthesis blocker (sulphonamides, trimethoprim, etc.) \[[@B7]\].

The *β*-lactam drugs are the most important and frequently used groups of antimicrobials that inhibit cell wall synthesis resulting in lysis of specifically bacterial cells and thus are bactericidal. They have been categorized, on the basis of the chemical structure with the *β*-lactam ring, into six major groups: penicillins, cephalosporins, cephamycins, carbapenems, monobactams, and *β*-lactamase inhibitors \[[@B8]\]. With the introduction of penicillin for the first time, people were optimistic to end the dominance of bugs and overcome the evils of pathogens; however, very soon, penicillin was seen ineffective against some infections due to emergence of resistance against penicillin and the optimism was slashed \[[@B9]\]. Nevertheless, this phenomenon of emergence of resistance had acceleratedpressure and presents challenge to healthcare experts. Resistance to *β*-lactam compounds is mainly due to the production of beta-lactamases (BLs) that hydrolyze and thereby inactivate beta-lactam antibiotics \[[@B14]\]. The complexity and heterogeneity of BLs can be estimated from the constantly increased discoveries, and today more than 900 types, produced by many different species of bacteria, are recognized. Because of the broad spectrum activity against the latest cephalosporin (the extended spectrum cephalosporins), the extended spectrum beta-lactamases (ESBLs) are of specific concern. Blind and persistent use of antibiotics is thought to be one of the important triggers to provoke and spread antibiotic resistance. The objectives of the current manuscript is to accumulate concise updates regarding resistance offered by ESBL producing*Enterobacteriaceae* with special emphasis on structural and functional diversity, clinical significance,


"mistakenly" (due to very close shape resemblances) pick these up (*β*-lactam in fact) to use them as building blocks during cell wall synthesis. Bacterial cell pays for this mistake that leads to acylation of the PBP and thus eventually renders the enzyme (transpeptidases) inactive with inhibition of the transpeptidation reactions resulting in accumulation of cell wall precursor units that trigger activation of the cell wall autocatalytic system, leading to cell lysis \[[@B16]\]. By simultaneously blocking transpeptidases and activating autolysin, *β*-lactams lead to disruption of the synthesis of cell wall and initiates its active destruction finally resulting into cell lysis and elimination of the bug.

2.2. Mechanism of Bacterial Resistance to *β*-Lactam Antibiotics {#sec2.2}
----------------------------------------------------------------

Antibiotic or antimicrobial resistance arises when the otherwise effective antibiotic or antimicrobials are no more effective ininhibitors such as clavulanic acid, sulbactam, and tazobactam. Classically, ESBLs are defined as enzymes originally derived or evolved from a narrow spectrum parent ESBL-enzyme and thus gained the ability to inactivate the broad spectrum cephalosporins, penicillins, and aztreonam, but not the cephamycins (cefoxitin) or carbapenems by hydrolytic activity and are inhibited by *β*-lactamase inhibitors, that is, clavulanic acid. The older and classical definition of ESBL includes derivatives from TEM-1, TEM-2, or SHV. Most recent definition divides ESBL into three main groups.

\(i\) ESBL~A~ (class A ESBLs) comprises the most frequently found ESBL and the CTX-M, as well as SHV and TEM enzymes. These enzymes are mainly horizontally transferable and can be inactivated or inhibited by clavulanic acid.

\(ii\) ESBL~M~ (miscellaneous ESBLs) are sectioned into ESBL~M-C~ (class C, plasmid mediated AmpC)


ESBL are infrequently identified or are very restricted; others are becoming locally prevalent or are progressively isolated globally.

6. Global Epidemiology of ESBLs {#sec6}
===============================

No doubt, the inception of the ESBL in clinical practices around 1980s had been seen as breakthrough against the most fatal and prevalent bugs which mainly belong to*Enterobacteriaceae*. However, this success resulted in massive use of cephalosporins that provide a selective pressure for the emergence of new variants of ESBLs. Major pathogens belonging to*E. coli*,*Salmonella*,*Klebsiella*, and*Proteus* have exploited two main schemes of ESBL evolution: (i) the selection of enzyme mutants with the ability of expanded substrate from already abundantly available plasmid mediated TEM and SHV type *β*-lactamases and (ii) the ability to acquire and integrate new *β*-lactamase genetic material from the ecological metagenome, coding enzymes thatto another in the bacterial nucleic acids through transposition and can be inserted nonspecifically at any place in the bacterial nucleic acids. There are numerous different kinds of transposons, but normally they contain a transposase promoting transposition, overturned repeats in the ends, and short direct repeats of target nucleic acids bracketing the transposons. Conjugative transposons are one more type holding genes for conjugative transfer from one cell to another. Though it rarely happens and is highly regulated, transposition is one of the genetic factors that contribute to spread of resistance elements. The most important element that has been shown highly associated with successful transmission of resistance elements is integrons \[[@B56]\]. These are genetic elements incorporated in transposons found on sets of plasmids and in the bacterial chromosome. These


gene capturing systems are progressed from site-specific recombination mechanisms, and a general integrin encodes a DNA integrase gene*(int)* and a neighboring recombination site*(att1)* \[[@B63]\]. Generally, within the variable region, multiple resistance associated genes could be integrated in the form of gene cassettes that are basically incorporated in the attachment site (attI) of the integron which can have many cassettes at once. Different integrons classes have been described, and classes 1, 2, and 3 have been associated with antibiotic resistance. Most often, they encode for multiple resistances and thus associated with coresistance. Importantly, integrons by itself are not able to jump, but their gene cassettes could be mobilized as they are often found as part of the transposons or plasmid and thus could be integrated into secondary sites, therebyrather the slow and persistence release of low amount of antibiotics in the environment (posttherapy period) that provide ample amount of time for bacteria to develop resistance. Altogether, we should really change our mentality and course of action against the use of antibiotics. First, we should emphasize implementing the shorter course of antibiotics. Secondly, cycling of the antibiotics should be considered if new antibiotics are available in the market. Thirdly, we should alongside invest in synthesizing or discovering new antibiotics such as improvement of the current tetracycline drugs; understanding the mechanism of resistance to currently available tetracycline drugs would help improve the efficacy. A chemical free, nonclassical approach to retreat the resistance problem would be the recovery of the vulnerable strain. We need to encourage the growth of


apparently not of his own free will. He was taken to Ft. Niagara and there confined in an unused magazine. Then Morgan disappeared! n16 What happened to William Morgan? Enemies of the Craft said Freemasons had kidnapped and murdered him, to prevent the publication of his exposé. Freemasons, of course, indignantly denied the charge. As time went on and Morgan was not found, members of the Craft disavowed any approval of any such act, if it had been committed. Governor Clinton, Past Grand Master, issued proclamation after proclamation, n21 the last one offering two thousand dollars reward "that, if living, Morgan might be returned to his family; if murdered, that the perpetrators might be brought to punishment." Cf. Cummings, pp. 30-31. Morgan in chains. [8] It was nothave committed. Did William Morgan choose the easier way, disappear with five hundred dollars from a dangerous situation, eliminating from his responsibilities a wife and family suddenly burdensome, and, in a new freedom, ship on a vessel from Montreal and out into the world, there to come to an unknown end? n19 Or was he basely murdered by Masons who thought the crime less than the evil results to follow on the publication of Morgans book. No man knows. No incontestable evidence can be adduced  or was ever adduced  definitely to prove either solution. All that is undoubted is that William Morgan was apparently kidnapped and did disappear. n19 It is difficult, a hundred years after, to understand the extent and power of the widespread excitement


or the shelter can be adapted to match the current conditions.

If you are willing to own two or more shelters, however, you can select more specialized models that perform better in niche conditions than a generalist, but worse in others. When the latter will be the case, you carry a different shelter.

Of course, this analysis ignores the possibility that your group size may change. If it is not practical to use an oversized (and slightly heavier) shelter that can accommodate an extra body, then this will likely multiply the number of needed shelters.

2. Modularity: Do the protections you need or want from your shelter vary or are they constant?

Personally, I backpack year-round and throughout the country. As such, I encounter diverse conditions, in terms of temperatures, precipitation, wind,Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions.
Rab GTPases regulate the membrane transport pathways by recruiting their specific effector proteins. Melanophilin, a putative Rab effector, has recently been identified as a gene that is mutated in leaden mice, in which peripheral localization of melanosomes is impaired in melanocytes. Genetic studies suggest that three coat-color mutation genes, dilute (MyoVa(d)), ashen (Rab27a(ash)), and leaden (Mlph(ln)), act in the same or overlapping pathways. Here we have cloned and characterized a human melanophilin homolog, which belongs to the rabphilin3/granuphilin-like Rab effector family. Cosedimentation assays using recombinant proteins reveal that melanophilin directly binds to Rab27a and myosin Va through its N-terminal and its first C-terminal coiled-coil region, respectively. Moreover, we show that Rab27a, melanophilin, and myosin Va form a


      ciphertext.extend(&flv_pad[..]); // 32 bytes CT for the flavor
        ciphertext.extend(&qty_pad[..]); //  8 bytes CT for the qty (u64-LE)
        let tag = self.compute_distinguisher(&ciphertext[0..72], &encrypted_value);
        ciphertext.push(tag); //  1 byte for the distinguisher

        assert!(ciphertext.len() == 73);

        let receiver = Receiver {
            opaque_predicate: self.control_key.clone(),
            value,
            qty_blinding,
           far as the 1960s.

Valery Koroshilov The Traveller

Since 1990, when the collection began, most of the works have been lent by artists, many of whom are local to the Centre's North London site. Some have been willing to let us hang some of their most engaging paintings, for example Jamie Boyd's mysterious Mediterranean landscapes. Perhaps some of these were offered because they are too large for private homes or even for galleries; some in gratitude because the artist or their families had been helped by the Clinic; and some because they supported vigorously the principle of good art in public buildings. One particularly rich haul of first-class work was made possible by the Connaught Brown Gallery's willingness to open up its warehouse, where many remarkable works were stored –


Mexico would pay for the construction project, but after taking office he included line items in his initial proposed federal budget to cover repairs to sections of the existing border fortifications and some new construction.

There have been no accurate cost estimations of how much the entire wall – over 2,000 miles long – would be because of varying prices of materials, labour, land clearing, and other factors.

Republicans have also floated a provision to end subsidies for low-income people to purchase health insurance under the Affordable Care Act, also known as Obamacare.

Democrats do not support any such legislation and the Republican replacement to Obamacare failed to even come up for a vote in the House of Representatives in March 2016 because of strong dissent within the Republican party.

Another point

Ask HN: Dealing with unsupportive parents - creating startup - jpd750

HN-
I've been telling myself for many years now I've wanted to create a company of my own and get out of the corporate misery.
I am a software developer by trade, and have worked with a few startups in the past.
Recently (past 5 months) I have been working on an idea, that is already a proven business model, and working on everything myself from the business end to the technical (dev) end.
I've saved up atleast 6 months of money, in order to live at home, and work on my product. My parents do not want this and think I should get a product together first and then quit ... which seems the most logical until..
You factor in:
-I'm working full


this effect was greatly improved when the concentration of SEO was 3% (v/v). S. aureus was found to be the most sensitive bacterium to SEO and showed a highest inhibition zone of 304.37 mm(2) in the microparticles incorporated with 3% (v/v) SEO. In vitro release studies showed an initial burst release and followed by a slow release. In addition, the release of SEO from the microparticles followed Fickian diffusion with acceptable release.as now, a civil rights movement used new technology to seize the nation’s attention (from satellite television in 1968 to Twitter today). And, then as now, a surge of White Americans voted for an insecure, power hungry, bigoted man with tendencies toward the dictatorial.

Then, as now, the Southern Strategy was used to great effect. Republican strategist Lee Atwater explained the Southern Strategy with what one can only assume was accidental candor:

You start out in 1954 by saying, ‘Nigger, nigger, nigger.’ By 1968 you can’t say ‘nigger’ — that hurts you, backfires. So you say stuff like, uh, forced busing, states’ rights, and all that stuff, and you’re getting so abstract. Now, you’re talking about cutting taxes, and all these things you’re talking about are totally economic things and