#[macro_use]
extern crate serde_derive;
extern crate actix_web;

use std::cell::RefCell;
use actix_web::{fs, server, App, Json, HttpRequest, HttpResponse, Responder};
use actix_web::http::{self, header, Method};

struct AppState(RefCell<i64>);

#[derive(Deserialize)]
struct NewState {
    value: i64,
}

impl AppState {
    fn new() -> Self {
        AppState(RefCell::default())
    }
}

fn count_up(req: HttpRequest<AppState>) -> impl Responder {
    *req.state().0.borrow_mut() += 1;
    format!("Count Up")
}

fn count_down(req: HttpRequest<AppState>) -> impl Responder {
    *req.state().0.borrow_mut() -= 1;
    format!("Count Down")
}

fn count_set((data, req): (Json<NewState>, HttpRequest<AppState>)) -> impl Responder {
    *req.state().0.borrow_mut() = data.value;
    format!("Count Set")
}

fn value(req: HttpRequest<AppState>) -> impl Responder {
    format!("Counter: {}", req.state().0.borrow())
}

fn main() {
    server::new(|| {
        App::with_state(AppState::new())
  the circuit. Namely, a control system for controlling power consumption of the circuit has been provided in addition to the control system for controlling the execution (arithmetic operation).
Meanwhile, another technique for realizing low power consumption of processor is disclosed in the Japanese Unexamined Patent Publication No. HEI 10-20959. In this cited reference, a power control field is provided within the instruction code and thereby the microprocessor operates only the necessary function blocks by decoding the power control field. However, it is also described that a method for controlling the feeding of power supply and a method for controlling the feeding of clock signal are proposed as the method of controlling the electrical power.
However, the practical circuit for controlling the feeding of power supply is never disclosed and moreover,


current control is performed prior to the arithmetic execution of circuit block considering that the transitional condition for the leak current control does not give any influence on the arithmetic execution.
An example of circuit block is an ALU (Arithmetic Logical Unit) and when an instruction to use ALU is executed, the execution mode in which the leak current of ALU is high level is designated. On the occasion of executing the instruction for not using ALU, the execution mode in which the leak current of ALU is low level is designated. It is enough for the judging circuit to issue a designating signal regarding the level of leak current of ALU on the basis of the information that an instruction designates use of ALU or not and thereforeconomic development and job retention that Kimberly-Clark can attempt to utilize, just as any other company can.”

The $2.8 billion in potential tax breaks for Foxconn, which is developing a Racine County manufacturing campus, was a “once-in-a-lifetime opportunity” and “not a template to provide extra benefits to any company who asks,” Kapenga added.

Two other GOP senators may want to avoid a vote on a tax-break package for K-C: Assistant Senate Majority Leader Leah Vukmir, of Brookfield, is running against Democratic U.S. Sen. Tammy Baldwin. And first-term Sen. Howard Marklein, a Spring Green accountant, is trying to fend off Democratic challenger Kriss Marion. Marquette University polls have found the Foxconn aid package is most disliked by residents who do not live in southeast Wisconsin.

Senate President, of Appleton, whose district includes


in two and a half years. This very recent version is quite different from the last one. This update focused on contents for light players who don't have much time to sit for MMORPG. The ideas were adopted by the requests from the players, which concentrates on "convenience" than "entertainment" features.

The main update is the "GEMOCON", the web control system which stands for "GE Remote Control". This is a system that will let you check how your character is doing, whether it's dead, or doing hunting while you're out. You can do it everywhere, where there is internet. You can also chat with other players through this system which will allow you to strengthen your community activity online.

HanbitSoft now owns both Hellgate: London, online action RPG and Mythos,London is now HanbitSoft’s game, and we have already formed a team. They are doing hard work for updates and patches. Service in Asia including Korea is in good hands” said Gi-Young Kim, CEO of HanbitSoft, and added “I believe Mythos is a very attractive MMORPG, just gaining large fans from couple of beta tests. It has a lot of potential and it will also be developed at studio in San Francisco with Hellgate: London. Both titles will be presented soon with upgraded features.”

About Me

About HanbitSoft
HanbitSoft Inc. is one of the largest online game publishers in Korea as well as in Asia. HanbitSoft has continuously invested in developing and publishing excellent and promising online games. HanbitSoft has broad portfolio of online games ranging from casual games to high-end


that were now a little too short; a now too tight sports bra, and a pink tank top with a whilte long sleeved T-shirt on top.

She went into the hall and banged on Charlie’s door.

“What?” Charlie yelled.

“Workout in forty-five minutes,” Sissy said as she leaned into the darkened room.

Charlie threw a pillow at her. Laughing, Sissy deftly tucked her head out of the room just in time. The pillow hit the door. Chuckling to herself, she went down the hallway toward the kitchen. She had just turned into the kitchen when the thought hit her.

Maybe Ivan was ashamed of sleeping next to the stupid little baby Sissy, who couldn’t even stand being by herself for a minute.

She stopped dead in her tracks. Her entire body flushed with shame.extensive coastline, large population and a high percentage of unmanaged waste are recipes for contributing significant amounts of land-derived debris into oceans. Studies have ranked Indonesia as the second-largest plastic waste contributor to the world's oceans after China^[@CR10],[@CR13]^. The Indonesian archipelago covers a 99,093 km-long coastline^[@CR14]^. It is home to the world's fourth-largest population (255.46 million) where a majority (57%) resides in Java Island^[@CR15]^ with a concentration around the capital city of Jakarta. Indonesia produces about 200,000 tons of waste annually with only 64% reaching landfills while the rest ends up in the environment^[@CR16]^. Despite the reported impacts of debris on marine organisms and fisheries in Indonesia^[@CR17],[@CR18]^, long-term monitoring studies that characterize major sources and seasonal variations of debris release into marine ecosystems are lacking. Willoughby^[@CR19]^ was the


(57,668 ± 16,559 items) or 37% by weight (8.32 ± 2.44 tons) of the total collected debris over the period June 2015 to June 2016. In the municipality of Tangerang, plastics represented 71% by abundance (18,273 ± 5,292 items) or 28% by weight (2.15 ± 0.88 tons). In Jakarta, plastics were 57% by abundance (19,327 ± 4,767 items) or 50% by weight (3.56 ± 0.77 tons) of the total collected debris. And in Bekasi, plastics represented 53% by abundance (20,066 ± 10,074 items) or 33% by weight (2.61 ± 1.31 tons). Debris under the wood/paper type was the second most abundant after plastics, while debris under the type of cloth/fiber was also prominent vis-à-vis weight particularly in Bekasi.Figure 2Percentages of debris type by abundance (top) and weight (bottom) in the nine river outlets into Jakarta Bay across the municipalities of Tangerang, Jakarta and Bekasiin Jakarta had a debris release of 33,626 ± 8,375 items or 7.07 ± 1.52 tons daily into Jakarta Bay. We investigated the possibility that the lower debris releases from individual river outlets in Jakarta may relate to any variation in river discharge. We find that river outlets in the municipality of Jakarta did not have lower discharges compared to their counterparts in Tangerang and Bekasi during the study period. The river discharge data show values of 11.10 m^3^/s in Tangerang, ranging between 4.10--39.70 m^3^/s for river outlets in Jakarta, and 20.90 m^3^/s in Bekasi (see Methods: Rainfall and River Discharge). We conclude that Dadap River in Tangerang and Bekasi River indeed had higher densities of debris flowing into Jakarta Bay relative to river outlets in Jakarta.Figure 3Boxplot of debris release by


1. Introduction {#sec1-molecules-25-03026}
===============

Silver nanoclusters (AgNC) are a novel class of nanomaterials that are only a few atoms in size. Cytosine-rich nucleic acid sequences template and stabilize silver nanoclusters limiting their size and modifying their electronic properties. The continuous density of states, typical for metal structures, breaks up into discrete energy levels in the nanoclusters. The nanoclusters resemble molecular-like behavior with strong fluorescence observed in the wide range of the spectrum, from UV to visible to near IR \[[@B1-molecules-25-03026],[@B2-molecules-25-03026]\]. AgNCs are more stable in photobleaching than widely used organic dyes, quantum dots, or fluorescent proteins \[[@B3-molecules-25-03026],[@B4-molecules-25-03026],[@B5-molecules-25-03026]\]. These properties make AgNCs suitable for a plethora of practical applications including luminescent labelling, biological imaging, sensing, and catalysis \[[@B6-molecules-25-03026],[@B7-molecules-25-03026],[@B8-molecules-25-03026]\]. The high sensitivity of emissive properties of the AgNCs to subtle changes intheir environment have triggered an exploration of practical use of the AgNCs in sensing applications. Since the precise knowledge of metal nanocluster photophysics is still lacking, further understanding of the energy transfer mechanism when utilizing metal nanoclusters is expected to result in a broader interest of utilizing nanoclusters in biosensing applications \[[@B9-molecules-25-03026]\].

The use of DNA-templated silver nanoclusters has been proposed for the detection of a variety of species based on fluorescence quenching or fluorescence enhancement. For example, sulfide S^2-^ ions have been effectively detected \[[@B10-molecules-25-03026]\]. DNA-templated silver nanoclusters have been shown to be responsive to the presence of various metal ions. For example, the sensing of Cu^2+^ \[[@B11-molecules-25-03026],[@B12-molecules-25-03026],[@B13-molecules-25-03026]\] was demonstrated with the use of silver nanoclusters hosted in the polymethyl methacrylate (PMMA) network \[[@B14-molecules-25-03026]\] or glutathione (GSH) ligand


fluids and the levels of miR-21, it may be possible to differentiate cancer patients from healthy individuals and detect cancer at early stages dependent on the diagnostic potential of miR-21 as a biomarker. Thus, new methods for the rapid and sensitive detection of miRs are of paramount importance in the field of cancer diagnostics.

Recently, several designs utilizing DNA-based AgNCs have been exploited for the detection of various miR sequences \[[@B27-molecules-25-03026],[@B28-molecules-25-03026],[@B29-molecules-25-03026],[@B65-molecules-25-03026]\]. The detection strategy for miR molecules is primarily based on a clever construction of the AgNC probe which involves two separate domains: the recognition domain and the signaling domain. The signaling domain templates and stabilizes AgNCs while the recognition domain specifically binds to biomolecules needed to be detected: specific gene sequences, protein aptamers, and nucleic acid sequences suchto 0.25 and then to 0.5, and after that it stays almost the same at high molar equivalents of miR-21 added. Such behaviour invalidates the possibility of using "red" emission as a read-out signal for the quantitative analysis of miR-21. On the other hand, steep changes in intensity of "green" fluorescence may be, in fact, considered as a detection read-out method. Indeed, as shown in [Figure 4](#molecules-25-03026-f004){ref-type="fig"}B, the maximum intensity of the peak plotted versus the concentration of added miR-21 exhibits a sigmoidal behaviour: the larger the amount of added analyte sequence, the larger the intensity of "green" fluorescence.

Such sigmoidal dependence between the signal intensity and analyte concentration can be described statistically by utilizing the four-parameter logistic (4PL) curve for calculating the analytical limit of detection (LOD) of


16.40F-Q-10 (from StarnaCells, Inc., Atascadero, CA, USA). The excitation--emission matrix spectra (EEMS) were recorded with 2 nm resolution. Fluorescence spectra were recorded with the emission wavelength ranging from 270 nm to 800 nm, and the initial excitation wavelength was set to 220 nm and the final excitation wavelength was set to 700 nm with an increment of 2 nm. The slits were open to 10 µm and the PMT voltage was set to 700 V. Matrix data were then used for 2D contour plot using MagicPlot Pro software.

4. Conclusions {#sec4-molecules-25-03026}
==============

In this work, we developed a novel method to detect miR sequences with the use of silver nanoclusters. The proof of principle was demonstrated on detection of miR-21 molecules but can be easily generalized to other miR sequences. ThePartial correction of the dwarf phenotype by non-viral transfer of the growth hormone gene in mice: Treatment age is critical.
Non-viral transfer of the growth hormone gene to different muscles of immunodeficient dwarf (lit/scid) mice is under study with the objective of improving phenotypic correction via this particular gene therapy approach. Plasmid DNA was administered into the exposed quadriceps or non-exposed tibialis cranialis muscle of lit/scid mice followed by electroporation, monitoring several growth parameters. In a 6-month bioassay, 50μg DNA were injected three times into the quadriceps muscle of 80-day old mice. A 50% weight increase, with a catch-up growth of 21%, together with a 16% increase for nose-to-tail and tail lengths (catch-up=19-21%) and a 24-28% increase for femur length (catch-up=53-60%), were obtained. mIGF1 serum levels were ~7-fold higher


Mulchén River

The Mulchén River is a river of Chile.

See also
List of rivers of Chile

References
 La Cuenca del Río Biobío

Category:Rivers of Chile
Category:Rivers of Biobío Regionalso discussed by Masson, J. Autoimmunity, 6: 683-689 (1993).
WO 94/04689 discloses a protein with a cytotoxic domain, a ligand-binding domain and a peptide linking these two domains comprising an IgG constant region domain having the property of increasing the half-life of the protein in mammalian serum.
A stereo drawing of a human Fc fragment and its complex with fragment B of Protein A from Staphylococcus aureus is provided by Deisenhofer, Biochemistry, 20: 2364 (1981).
It has been shown that clearance is greatly reduced when the effective molecular size exceeds 70 kDa, the glomerular filtration cutoff size. Knauf et al., "Relationship of Effective Molecular Size to Systemic Clearance in Rats of Recombinant lnterleukin-2 Chemically Modified with Water-soluble Polymers," J. Biochem., 263: 15064-15070 (1988).


the Vikings as a reporter and columnist since 2009. Murphy is a Detroit native and Wayne State University graduate.

As you comment, please be respectful of other commenters and other viewpoints. Our goal with article comments is to provide a space for civil, informative and constructive conversations. We reserve the right to remove any comment we deem to be defamatory, rude, insulting to others, hateful, off-topic or reckless to the community. See our full terms of use here.

More in Sports

Glen Perkins’ 16-month comeback odyssey reached fruition Thursday afternoon as the decorated Twins reliever trotted in from the bullpen to pitch the ninth inning against the Cleveland Indians with a four-run deficit. It hardly mattered to Perkins, activated off the 60-day disabled list for his first big-league outing since April10, 2016, that he was being eased back into the...

Gophers football coach P.J. Fleck spent eight minutes breaking down why he declared Thursday that both Demry Croft and Conor Rhoda will play in the season opener against Buffalo on Aug. 31. Whether the sophomore Croft or the senior Rhoda takes the first snap at TCF Bank Stadium will be inconsequential, Fleck said, and despite how one of them performs...

Max Kepler made up for his embarrassing miscue in memorable fashion. Shortly after his slip on the slick outfield grass allowed the tying run to score in Thursday’s doubleheader nightcap, Kepler cracked his 15th homer of the season to lift the Twins to a 4-2 win over the Cleveland Indians. That seventh-inning turnabout ended a 10-game home losing streak against...

Stephane


who received PPB and EBRT was 40.0% and 37.5%, respectively. In contrast, the rate of very high and high trait anxiety in the RRP group was much lower (23.7%). Trait anxiety showed a high correlation with state anxiety and the mental health component summary of SF-8 (correlation coefficient=0.715, -0.504). Trait anxiety was associated with the degree of state anxiety regarding treatments for PCa, followed by change in state anxiety, which might have effects on psychological well-being. Information regarding state anxiety as a consequence of treatments and trait anxiety measurement tool are important considerations for treatment decision-making in newly diagnosed PCa patients.'';
};

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Compiler.prototype.__proto__ = Visitor.prototype;

/**
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Compiler.prototype.compile = function(){
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};

/**
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Compiler.prototype.__defineGetter__('indent', function(){
  if (this.compress) return '';
  return new Array(this.indents).join(Array(this.spaces + 1).join(' '));
});

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Compiler.prototype.visitRoot = function(block){
  this.buf = '';
  for (var i = 0, len = block.nodes.length; i < len; ++i) {
    var node = block.nodes[i];
    if (this.linenos || this.firebug) this.debugInfo(node);
    var ret = this.visit(node);
    if (ret) this.buf += ret + '\n';
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};

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Compiler.prototype.visitBlock = function(block){
  var node;

  if


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      ? (self.compress ? ',' : ', ')
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  });

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};

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/**
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    + (this.compress ? ':' + val : ':   }
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'\\$1');
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Burqibah - Supplied)

“Two rescue men were at the beach, and they rushed to help the girl.

“However, there was one obstacle which prevented them from reaching the girl and helping her.

“This obstacle was the belief of this Asian man who considered that if these men touched his daughter, then this would dishonour her.

“It cost him the life of his daughter.”

Revealing that the dad was a “tall and strong man”, Lt Burqibah said that there was a violent struggle, adding to Emirates 247: “He told them that he prefers his daughter being dead than being touched by a strange man.”

The fight delayed the rescue and the woman drowned.

Lt Burqibah said: “She died unfortunately, at a time when she had a chance to live, especially that the rescue men were so


walking for recreation and transportation among older adults.

Another finding of this study was that older adults without full-time jobs and with higher levels of education were more likely to walk for recreation, while those living in non-metropolitan areas were less likely to walk for transportation purposes. Consistent with previous findings \[[@B16-ijerph-14-01594],[@B17-ijerph-14-01594]\], older adults with lower educational levels may be more likely to have inactive lifestyles and lower health literacy \[[@B26-ijerph-14-01594],[@B27-ijerph-14-01594]\], making them less likely to walk during their leisure time. In addition, the present results suggest that older adults without full-time jobs may have more spare time for recreational walking. Consistent with a previous study \[[@B17-ijerph-14-01594]\], older adults living in non-metropolitan areas were less likely to walk for transportation than those living in metropolitan areas. This result couldbe explained by the fact that non-metropolitan areas have low residential density, poor infrastructure, and poor access to public transportation. Thus, it is important to target older adults with lower levels of education and full-time jobs, encouraging them to engage in recreational walking. They should also be encouraged to improve and increase their awareness of infrastructure and transportation options in non-metropolitan areas in order to support walking for transportation among older adults.

This study has several limitations. First, because of the cross-sectional design, we could not draw conclusions regarding causal relationships. Secondly, the outcome and exposure variables of this study were self-reported, and thus subject to bias. Thirdly, the self-selection of neighborhoods and weather conditions (factors with the potential to confound our results) were not controlled in this study.


ultimately helping older adults to achieve 150 min/week of walking. Different perceived environmental factors were also observed. These findings suggest that policy-makers and physical activity intervention designers should develop both common and specialized environmental strategies in order to improve and increase awareness of the neighborhood environment, as a way of promoting recreational and transportation-related walking behaviors among older adults.

This work was supported by a Global Research Network program through the Ministry of Education of the Republic of Korea and the National Research Foundation of Korea (NRF-Project number) (NRF-2017S1A2A2038558).

Conceived and designed the experiments: Yung Liao, Jong-Hwan Park. Analyzed the data: Yung Liao, Pin-Hsuan Huang. Wrote and revised the paper: Yung Liao, Chih-Yu Hsiang, Jing-Huei Huang, Pin-Hsuan Huang, Ming-Chun Hsueh, and Jong-Hwan Park. All the authors have read and approvedspectral energy distribution (§§5–7). Full details of the methods used, and a discussion of the implication of the results, are given in the main article (Stern & Laor, accepted).

Sample Creation
===============

The type 1 (T1) sample is selected from the SDSS 7[$^{\rm th}$]{} data release (DR7, Abazajian et al. 2009), based on the detection of a broad  emission line. The parent sample includes [232837]{} spectra with S/N $>10$ and $0.005<z<0.31$. The broad  emission is identified by modeling the nearby narrow emission lines, stellar absorption features and featureless continuum. We find broad  emission in [3579]{} objects (1.5%), which constitute the T1 sample.

The optical spectra in the T1 sample are supplemented by nearly complete near IR photometry from 2MASS (Skrutskie et al. 2006, detection rate 97%) and UV photometry from GALEX (Martin et al. 2005,


linear ${\nu L_{\nu}}$(UV)-${L_{\rm bH\alpha}}$ relationship at high luminosities (Fig. 4), this implies that the mean optical-UV net AGN SED has a fixed shape, and scales linearly with ${L_{\rm bH\alpha}}$.

![The ${L_{\rm X}}$ vs. ${L_{\rm bH\alpha}}$ relation, as a probe of true type 2 AGN. Dots mark T1 objects with $F_{\rm b{\text{H$\alpha$}}} >10^{-13.5}\ {\rm erg\ s^{-1}\ cm^{-2}}$. Red triangles mark mean upper limits in 0.5-dec ${L_{\rm bH\alpha}}$ bins. The best power law fit and dispersion are shown as black and gray lines (slope noted). Arrows mark the upper limits on ${L_{\rm bH\alpha}}$ of five true type 2 candidates.](fig6.eps)

![The ${L_{\rm X}}$ vs. ${L_{\rm bH\alpha}}$ relation, as a probe of true type 2 AGN. Dots mark T1 objects with $F_{\rm b{\text{H$\alpha$}}} >10^{-13.5}\ {\rm erg\ s^{-1}\ cm^{-2}}$. Red triangles mark mean upper limitsT1 objects follows the NEG luminosity function, with a relative normalization of $\sim 3$%, suggesting that the host of broad line AGN are NEG, and the AGN probability of occurrence is independent of the host mass.

4.  The dispersion in the optical-UV SED in luminous AGN ($\log {L_{\rm bH\alpha}}\ge 43$), is consistent with reddening. This indicates the intrinsic SED of AGN is blue, with a small dispersion, as predicted from thermal thin accretion disc models.

5.  The ${L_{\rm bH\alpha}}$ versus $L_{\rm{X}}$ correlation provides a useful probe for unobscured narrow line AGN. It can be used to test if the absence of a broad , in X-ray detected AGN, is significant.

References {#references .unnumbered}
==========

Abazajian K N 2009 [[*ApJS*]{}]{} [**182**]{} 543

Brinchmann J, Charlot S, White S D M, Tremonti C, Kauffmann G, Heckman T and


even some dating apps like Bumble have similar options.

For me though, the problem with any kind of one-off tweaks for limiting apps is that setting up your phone to only let you use precisely the apps you want, when you want, can feel like an impossible exercise. The same goes for customizing notification and badge settings.

It’s time-consuming and hard to anticipate which apps you’ll need when. One friend, who put limits on social app usage, ended up locking herself out of some logistical apps that she actually needed, including Lyft. Of course she could fix this, but as apps pop in and out of our lives, going by this program is a constant balancing act of utility versus trade-off.

Dumb phones

For someone like me who doesn’t want to botheris out of the question for me, I’m more likely to follow the advice of people who schedule regular weekend camping trips to places they know they won’t have cellphone service.

Turn it off

There’s also a seemingly too-obvious solution to all this: Turn off your phone. Some people do it for a couple hours at a time, or on one designated day of the week. For people who lack the self-discipline to do this, there are lockboxes and charging beds and all kinds of physical devices meant to isolate your phone if you don’t trust yourself to keep it off. But at the end of the day, many people find just turning off their cellphones and putting them far away works just fine.

Going gray

Despite the fact that phones continue


induces neutrophils to undergo apoptosis and promotes their efferocytosis by macrophages, as demonstrated in vivo in the mouse model of LPS-induced pleurisy \[[@CR20]\].

We postulated that neutrophil GILZ expression might be induced during ARDS, to modulate the inflammatory process and participate in lung repair. The aim of this pilot study was thus to analyze the kinetics of blood neutrophil GILZ expression at the protein and mRNA levels in ventilated septic patients with and without ARDS, and treated or not by corticosteroids. The levels of *gilz* mRNA were then analyzed according to ARDS severity, in comparison with some markers of inflammation (circulating CRP and extracellular DNA) or its resolution (Annexin A1), to assess whether GILZ might be included in a new biological signature of ARDS severity.

Methods {#Sec2}
=======

Study setting and populationcontrols (*p* = 0.665). However, predicted *gilz* mRNA levels were higher in severe ARDS patients than in controls (*p* = 0.035) and mild/moderate ARDS patients (*p* = 0.028) (Fig. [4](#Fig4){ref-type="fig"}a). Although *gilz* mRNA expression appeared variable in time, no linear interaction or association with time was found. We then examined whether *gilz* expression was related to the PaO~2~/FiO~2~ ratio and found that the correlation between *gilz* expression and a PaO~2~/FiO~2~ below 100 was very close to statistical significance (*p* = 0.054) (data not shown). Interestingly, *gilz* expression was significantly higher in ARDS patients receiving ECMO than in other ARDS patients (*p* \< 0.005) (Fig. [4](#Fig4){ref-type="fig"}b).Fig. 3*gilz* mRNA expression in the neutrophils of ARDS and controls (highest point of *gilz* expression for each patient). Results are expressed as the mean ± standard error of the mean. Relative quantity of *gilz* mRNA was expressed as


ARDS − 0.291 × severe ARDS − 0.036 × time. Fixed effects of the model with DNA are: 5.969 − 1.311 × mild/moderate ARDS + 0.167 × severe ARDS − 0.011 × time. Fixed effects of the model with *annexin A1* are: 0.400 − 0.125 × mild/moderate ARDS − 0.077 × severe ARDS + 0.003 × time

Together, these results show that GILZ can be expressed by neutrophils during the course of ARDS, at both the protein and gene level, and that its expression level is associated with clinical severity, more specifically than other markers of inflammation or its resolution.

Clinical definition of "*gilz*-positive" ARDS patients {#Sec14}
------------------------------------------------------

We then analyzed several features of "*gilz*-positive" patients (see above), including clinical parameters (ARDS, septic shock at inclusion, and pneumonia at inclusion \[[@CR32]\]), treatment, and mortality. Using the Chi-square test to assess whether or not two variables were independent, we found that neutrophil *gilz* gene expression was associated with ARDS (*p* \< 0.05) but not with septic shock  extracorporeal membrane oxygenation

FiO~2~

:   fraction of inspired oxygen

ICU

:   intensive care unit

GCs

:   glucocorticoids

GILZ

:   glucocorticoid-induced leucine zipper

NETs

:   neutrophil extracellular traps

PaO~2~

:   partial pressure of arterial oxygen

PEEP

:   positive end-expiratory pressure

ROS

:   reactive oxygen species

SAPS II

:   Simplified Acute Physiology Score II

SOFA

:   Sequential Organ Failure Assessment Score

SS

:   septic shock

Sylvie Chollet-Martin and Armelle Biola-Vidamment have contributed equally to this work

MAE and BN carried out quantitative PCR and Western blot. VG and LdC performed extracellular DNA analysis. PP, GD, and PM conducted patient inclusions. DH performed the statistical analysis. MAE, FT, SCM, PM, and MP participated in the design of the study and in the interpretation of the results. ABV conceived the study and


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func (msghdr *Msghdr) SetIovlen(length int) {
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func (cmsg *Cmsghdr) SetLen(length int) {
	cmsg.Len = uint64(length)
}

func InotifyInit() (fd int, err error) {
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}

func Dup2(oldfd int, newfd int) (err error) {
	return Dup3(oldfd, newfd, 0)
}

func Pause() error {
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	return err
}

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		*ts = NsecToTimespec(int64(timeout) * 1e6)
	}
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		return ppoll(nil, 0, ts, nil)
	}
	return ppoll(&fds[0], len(fds), ts, nil)
}

func Renameat(olddirfd int, oldpath string, newdirfd int, newpath string) (err error) {
	return Renameat2(olddirfd, oldpath, newdirfd, newpath, 0)
}

//sys	kexecFileLoad(kernelFd int, initrdFd int, cmdlineLen int, cmdline string, flags int) (err error)

func KexecFileLoad(kernelFd int, initrdFd int, cmdline string, flags int) error {
	cmdlineLen := len(cmdline)
	if cmdlineLen > 0 {
		// Account for the additionalMultiplex mass spectrometric imaging with polarity switching for concurrent acquisition of positive and negative ion images.
We have recently developed a multiplex mass spectrometry imaging (MSI) method which incorporates high mass resolution imaging and MS/MS and MS(3) imaging of several compounds in a single data acquisition utilizing a hybrid linear ion trap-Orbitrap mass spectrometer (Perdian and Lee, Anal. Chem. 82, 9393-9400, 2010). Here we extend this capability to obtain positive and negative ion MS and MS/MS spectra in a single MS imaging experiment through polarity switching within spiral steps of each raster step. This methodology was demonstrated for the analysis of various lipid class compounds in a section of mouse brain. This allows for simultaneous imaging of compounds that are readily ionized in positive mode (e.g., phosphatidylcholines and sphingomyelins)


A review of projective test findings with older adults.
The projective test literature on aging is reviewed. It was concluded that, while much critical research remains to be done and many of the studies are flawed, projective testing has contributed a great deal to the understanding of the aging process and has yielded a core of consistent findings. Suggestions for future research which would help resolve some current ambiguities were made.of a (probably not so well designed, it is FoxPro) legacy application by someone fresh out of school isn't an acceptable task. Unless you have a Sr. Developer (or at least someone with a few years experience) guiding the design and doing code reviews.
–
RigJul 7 '12 at 16:15

10 Answers
10

Before asking if your current employer is asking too much, you should ask yourself if your manager is aware that you are having these difficulties in the first place.

In my own experience, most problems inside and outside of work stem from poor communication. I've been in teams where developers have been afraid to speak up in case it put their employment in jeopardy. Last month, one of my team members handed his notice in and the team was brought into


you are facing and suggest improvements you would like to make. Go grab a coffee with him or go to the pub after work. The worst case scenario is that he ignores you and tells you to get back to work. At that point, you know it's time to pack up.

The issue is he is approachable and I discuss issues many times with him,but they are so busy supporting their old software that after some time I again find myself all alone in this fight.But still I will consider communication again.Thanks.
–
priyank patelJul 7 '12 at 9:51

Is there a reason why you are working on this solo? Is the company on a tight budget or do they feel the project isn't big enough to warrant hiring a few extraAmid the Boko Haram insurgency and administrative hurdles, tens-of-millions of Nigerians could be unable to vote in this month’s general election. The February 14 ballot will be the first election in the young democracy’s history – in which polls suggest a close race between rival candidates. CCTV America’s Susan Roberts interviewed Nii Akuetteh, former Executive Director of Africa Action. He discussed the Nigerian elections and its challenges.

Amid the Boko Haram insurgency and administrative hurdles, tens-of-millions of Nigerians could be unable to vote in this month's general election. The February 14 ballot will be the first election in the young democracy's history - in which polls suggest a close race between rival candidates. CCTV America's Susan Roberts interviewed Nii Akuetteh, former Executive Director of Africa Action. He discussed the


companies looking to use the tour for corporate entertainment and advertisement.

Rarely are N.B.A. players called upon to play one-on-one with a corporate executive whose decision to write a sponsorship check is predicated on whether one had a good time shooting free throws with Kobe Bryant.

There is much more to it, but a large part of the economic success of a golf organization is predicated on whether a corporate entity decides to underwrite a tournament and whether a television network decides to broadcast it. All of those decisions are based on the tour’s being able to market its athletes.

The L.P.G.A. started a program in 2006 to help international players learn English and transition into American culture.

“It’s been very successful thus far,” Galloway said.

here are risks to the path onmake sense. The way the races interact with each other has to make sense. You have to know how it all fits together. The way you do that is you do a history of the world," Salvatore said.

Salvatore is best known for his novels set in the Forgotten Realms universe, but he's also an avid MMO gamer, and he spent much of his talk telling stories about his time spent playing the original EverQuest. The author has also spent decades playing Dungeons & Dragons, and he tested out the early ideas for Copernicus on his D&D group. Although he's a writer at heart, he said he also understands what game narratives need.

"The primary difference between writing books and writing games is, when I write a book I'm giving


best use of email. When they should send emails. How they should send them. How to use video email! How fast they should you be? What they should you say on the phone? Let’s record their calls. Let’s coach.

COACH, COACH, COACH. TRAIN, TRAIN, TRAIN! I heard another company I work with say: “Coach them up, or coach them out.” That’s a good term, isn’t it? Write that down. Coach them up, or Coach them out. It should happen here too.the rainy season \[[@pone.0205316.ref012]\].Children between two months and 12 years admitted with suspicion of acute CNS infection based on fever or history of fever in the past 48 hours and recent onset of at least one sign of CNS involvement. CNS symptoms and signs included: non-traumatic reduced level of consciousness, prostration, hypertonia/hypotonia, irritability, severe headache, photophobia, neck stiffness, bulging fontanelle, prolonged seizures, focal neurological signs, purpura or Cheyne stokes breathing. Children who met the criteria above were enrolled into a prospective descriptive cohort study between August 2009 and October 2012. A more complete description of the study population and methods is provided elsewhere \[[@pone.0205316.ref011]\].

Clinical and laboratory investigations {#sec004}
--------------------------------------

Socio-demographic and clinical characteristics of the participants including age, gender, HIV exposure, history and type of previous treatment as well as


clinical information at admission and discharge and treatment received were recorded in a standardized case report form \[[@pone.0205316.ref011]\]. Diagnosis at admission was based on clinical examination and systematic testing with a rapid diagnostic test for malaria (SD-Bioline Malaria Antigen P.f/Pan, Standard Diagnostics, Korea).

Final diagnosis was informed by biological investigations of blood and cerebrospinal fluid (CSF). Sample collection was performed systematically upon inclusion. Venous blood samples were collected aseptically into two single bottle blood-culture system (Signal Blood Culture System, Oxoid) and into EDTA tubes for hematological analyses. CSF was aseptically obtained by lumbar puncture into sterile CSF tubes. To diagnose bacterial pathogens, blood and CSF were analyzed at the Epicentre research laboratory on site following standardized bacteriology procedures \[[@pone.0205316.ref011]\]. Culture, staining, biochemical testing were used to identify any bacterialtreatment given for less than 5 days for bacteremia or 10 days for bacterial meningitis, or for less than the number of days of hospitalization for those who died or were discharged against medical advice before the recommended treatment duration.

*Excessive treatment duration* was defined as an antimalarial given for more than 8 days or an antibiotic treatment given for more than 21 days for bacterial infections. The rationale for 21 days was to adequately treat for meningitic syndromes that require an extended treatment period such as infections resulting from *Enterobacteriaceae* or *Listeria monocytogenes*.

Double data entry and data validation was done using EpiData Entry software (version 3.1, EpiData Association, Odense, Denmark) and analysis was performed using Stata (version 12, College Station, Texas, USA).

Results were analyzed using descriptive statistics to


the study ([Fig 1](#pone.0205316.g001){ref-type="fig"}); 20 children were excluded because they were enrolled 48 hours after admission, for a diagnosis at admission different from a suspected CNS infection and one child was excluded because he had been included twice in one month.

![Study flow-chart.](pone.0205316.g001){#pone.0205316.g001}

Of the 459 children with suspected acute CNS infections, 291 (63.4%) were boys. The median age was 30 months (interquartile range (IQR): 11--60). A significant proportion of children presented with reduced consciousness (71.7%) and/or seizures on admission (51.9%). Clinical characteristics at admission are presented in [Table 1](#pone.0205316.t001){ref-type="table"}. Fifty-eight (12.6%) of the children had been hospitalized elsewhere in the month before their admission, for a median duration of 2 days (IQR: 1--4).

10.1371/journal.pone.0205316.t001

###### Socio-demographic and clinical characteristics at inclusion of patients overall, survivors and non-survivors by delay between admissionempirical use of a third-generation cephalosporin on admission appears to be justified in this setting, but the evidence of emerging resistance to cephalosporins among enterobacteria emphasizes the need for close monitoring of antibiotic resistance.

Supporting information {#sec015}
======================

###### Study dataset.

All dates in the dataset were randomly modified to ensure data anonymization.

(XLSX)

######

Click here for additional data file.

We would like to thank all participants in the study and their parents, and the study team in the ward: Kalubi Peter, Jenifer Zungu, Dickson Tumusiime and Grace Kekirunga, Gervase Ndyanabo, Kemigisa Rose, Amerias Arimpa, Masturah Nakanwagi and Doreen Mpeirwe; and in the laboratory: Victoria Katawera, Sulaiman Muwanga, Daniel Omoding, Harriet Adrama, Thadeous Tuhuro, Arnold Ayebare, Patrick Orikiriza and Celine Gazin.

[^1]: **Competing Interests:**The authors have declared that no competing interests exist.


regex.findall(line)
          for key in to_replace:
              prop=key[0]
              value=key[1]
              name='.'+prop+'-'+value
              if prop and value in keyword:
                var1 =('\n'+name+'{'+
                  '\n'+keyword[prop]+': '+
     One of the results of the increase in everyday mobility and urban sprawl is that individuals are having to travel through spaces whose geography they are not necessarily familiar with. Also, driving assistance devices based on geolocation and navigation have proliferated over a number of years.
Like satellite guidance systems, these devices enable the individuals in cars, on a motorbike, on a scooter or on foot to move around with full knowledge of where they are located, and knowing what path to take to get from one point to another. The individuals are thus no longer lost and can even optimize their journey by having themselves guided over routes that are faster, less costly, or include services such as a gas station or a hospital.
The best known and most


= {isa = PBXFileReference; lastKnownFileType = sourcecode.c.h; path = LSApplicationWorkspace.h; sourceTree = "<group>"; };
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/* Begin PBXFrameworksBuildPhase section */
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/* End PBXFrameworksBuildPhase section */

/* Begin PBXGroup section */
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			);
			path = Tools;
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				2DBBEB07201C8BB900780B3C /* MJAppTools */,
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			sourceTree = "<group>";
		};
		2DBBEAB8201C6E7600780B3C /*


the output of $H$ different filter kernels $K$, with different scales $\theta^1,\ldots,\theta^H$. All kernels use the same feature transformation $\Lambda$ which allows for easier pre-computation of pairwise difference and avoids an over-parametrization of the filters. The outputs of different filters $\hat{{\mathbf{z}}}^h$ are combined linearly to produce $\bar{{\mathbf{z}}}$: $$\bar{{\mathbf{z}}}_c = \sum_{h=1}^H {\mathbf{w}}_c^h \hat{{\mathbf{z}}}_c^h,
  \label{eq:module}$$ using individual weights ${\mathbf{w}}_c^h$ per scale $\theta^h$ and channel $c$. The weights ${\mathbf{w}}\in \mathbb{R}^{H\times C}$ are learned using error-backpropagation. The result of the inception module has $C$ channels for every of its $Q$ points, thus $\bar{{\mathbf{z}}} \in \mathbb{R}^{Q \times C}$. The inception module is schematically illustrated in Fig. \[fig:inception\]. In short, information from CNN layers below is filtered using bilateral filters defined in transformed feature space ($\Lambda \mathbf{f}$). Most operations in the inception module areto propagate label information to the full image resolution. Other interpolation techniques are possible, including the well known bilinear interpolation, up-convolution networks [@zeiler2010deconvolutional], and DenseCRFs [@krahenbuhl2012efficient]. The quantization error mentioned in Sec. \[sec:superpixels\] only enters because the superpixels are used for interpolation. Also note that a fixed grid, that is independent of the image is a hard choice of where information should be stored. One could in principle evaluate the CNN densely, at all possible spatial locations, but we found that this resulted in poor performance compared to interpolation methods.

### Backpropagation and Training.

All free parameters of the inception module ${\mathbf{w}}$, $\{\theta^h\}$ and $\Lambda$ are learned via backpropagation. We also backpropagate the error with respect to the module inputs thereby enabling the integration of our inception modules inside CNN frameworks without breaking


the base model. Similar to the previous experiments, the inception modules achieve better performance than DenseCRF while being faster. The majority of the computation time in our approach is due to the extraction of superpixels ($5.2s$) using a CPU implementation. Some visual results with [BI$_{6}(2)$]{}-[BI$_{7}(6)$]{} model are shown in Fig. \[fig:street\_visuals\] with more in supplementary.

Conclusion
==========

The DenseCRF [@krahenbuhl2012efficient] with mean field inference has been used in many CNN segmentation approaches. Its main ingredient and reason for the improved performance is the use of a bilateral filter applied to the beliefs over labels. We have introduced a CNN approach that uses this key component in a novel way: filtering intermediate representations of higher levels in CNNs while jointly learning the task-specific feature spaces. This propagates information between earlier and more detailed intermediatewith male coyotes, there
could be major problems within the wolf pack structure because
the size of the offspring would be more uniformed.

To the north of Algonquin Park, the female Eastern Canadian
wolf seems to be mating with the male gray wolves, so there
hasn't been a drastic drop-off in size, since some of these
big gray wolves weigh well over one hundred pounds. They
are predators of moose and caribou. The Eastern Canadian
wolf weighs on average 50-70 pounds, and they hunt smaller
pray like deer and beavers.


   <mvc:resources mapping="/js/**" location="/js/" />

       <mvc:annotation-driven/>

      <bean id="viewResolver"
            class="org.springframework.web.servlet.view.InternalResourceViewResolver" >
          <property name="prefix">
           <value>/WEB-INF/</value>
         </property>
        <property name="suffix">
         <value>.jsp</value>
        </property>

      </bean>

but .js file is not linked up, please give me a directions, thanks in advance!!!

A:

I think you should put ${pageContext.servletContext.contextPath} and you should notice the name (and version ) declare in Spring-dispatcher-servlet.xmlmust same with the file in /js directory (jquery-1.6.2.js,jquery-1.11.1.js, jquery.js v.v...)
<script type="text/javascript" src="${pageContext.servletContext.contextPath}/js/jquery-1.6.2.js"></script>

and as everyone suggest, make sure you have
<mvc:resources mapping="/js/**" location="/js/" />

in Spring-dispatcher-servlet.xml
hope it work


those values.”

The letter also makes reference to Alexander's Little Plaid Book, a short work of political advice he published in 1998. The letter said he should follow the book's advice to “serve two terms, then get out,” rather than fall into a “mire of hypocrisy.”

The letter is signed by 20 different groups, most of them county-level Tea Party organizations in Alexander’s state.

Alexander has played a major role in crafting several bipartisan Senate measures in recent months. In July, he helped break an impasse over federal student loan rates, and in June, he supported the Senate’s immigration reform bill.

Alexander is not the first senator against whom Tea Party groups have exerted pressure. Senate Minority Leader Mitch McConnell Addison (Mitch) Mitchell McConnellMcConnell focuses on confirming judicial nominees with COVID-19 talksseries representation of the dS group and propagate inside the dS light-cone [@brgamo; @gata; @gagata; @taazba; @berotata; @ta1403]. They correspond to the massive Poincaré fields in the null curvature limit. For constructing the quantum field operator, one must first define the creation and annihilation operators on corresponding Hilbert space ${\cal H}$. The Hilbert space and the quantum states can be exactly defined by the UIR of the principal series [@tak; @ta1403]. The massive field operators are defined as a map on the Fock space: $$\label{fockspacem}
\mbox{Massive Field Operators}: \;{\cal F}({\cal H}) \longrightarrow {\cal F}({\cal H}),$$ which is constructed by the corresponding Hilbert spaces. The massive tensor(-spinor) field can be written in terms of the massive scalar field [@brgamo; @gata; @gagata; @taazba; @berotata; @ta1403]: $${\cal K}_{\alpha_1...\alpha_l}^{(\nu)}(x)=D_{\alpha_1...\alpha_l}(x,\partial,\nu) \phi^{(\nu)}(x),$$ where $\nu$ is


[@tak; @ta1403], which will be recalled in the next section. There exist the three types of massless gauge fields on the dS ambient space formalism; spin-$1$ vector fields $K_\alpha$, spin-$\frac{3}{2} $ vector-spinor fields $\Psi_\alpha$ and spin-$2$ fields. For a spin-$2$ field there are two possibilities for construction of the quantum field operator: a rank-$2$ symmetric tensor field $H_{\alpha\beta}$ and a rank-$3$ mix-symmetric tensor field ${\cal K}_{\alpha\beta\gamma}$ [@fr84], $${\cal K}_{\alpha\beta\gamma}=-{\cal K}_{\alpha\gamma\beta},\; \;{\cal K}_{\alpha\beta\gamma}+{\cal K}_{\gamma\alpha\beta}+{\cal K}_{\beta\gamma\alpha}=0.$$ The rank-$2$ symmetric tensor field, in dS ambient space formalism, can be written in terms of massless minimally coupled scalar field [@taro12; @khrota], but breaks the conformal transformation [@bifrhe; @tatafa; @tata]. For preserving the conformal transformation, the spin-$2$ field may be represented by a rank-$3$ mix-symmetric tensor field ${\cal K}_{\alpha\beta\gamma}$ [@bifrhe; @tatafa; @tata]. The$X^{a\beta\gamma}$: $$(Q_{0}-2)X^{a\beta\gamma}=0,\;\;\partial^{\top\alpha}X^{a\beta\gamma} \partial^{\top}_{\alpha}{\cal K}_{\rho\beta\gamma}=0,\;\;   {\cal K}_{\alpha\beta\gamma}\partial^{\top\alpha}X^{a\beta\gamma}=0,$$ and the divergence-less condition $\partial^\top \cdot {\cal K}_{.\beta\gamma}=0=\partial^\top \cdot {\cal K}_{\alpha.\beta}$, the tensor field ${\cal K}_{\alpha\beta\gamma} $ satisfy the following field equation $$Q_{0}^{(1)}{\cal K}_{\alpha\beta\gamma}=0.$$ If we impose the subsidiary traceless condition $ {\cal K}_{\cdot \cdot   \gamma}=0$, this field can be associated with the $j=p=2$ UIR of the discrete series of de Sitter group. This is exactly the massless gauge field ${\cal K}_{\alpha\beta\gamma}$.

There exist another gauge field [*i.e.*]{} the massless vector-spinor gauge fields $\Psi_\alpha$. This gauge potential is a spinor and also a Grassmannian function, satisfying the anti-commutation relations. The corresponding infinitesimal generators $({\cal Q}_i)$ must be a spinor in the ambient space formalism and must satisfy the anti-commutation relations. Nevertheless, such algebra would not be closed, since the


persons who have done or still do you wrong. Think about what they have done to you and how they have hurt you and how they deserve a good solid kick in the you know where.

Paul is sending Philemon a letter through the hands of a man (Onesimus) who had apparently done him very dirty. Onesimus did something to harm Philemon, ran away, ran into Paul, ran into Jesus, became a brother in Christ, and is now going back to hopefully make things right with his former employer.

The challenge in the letter is not on Onesimus. Nope. It’s on Philemon to receive Onesimus as a brother.

You read that right. Philemon – the “innocent” party was to receive back in full measure Onesimus – the “guilty” one. Philemon wascDNA sequences of three sheep myeloid cathelicidins.
Several myeloid antimicrobial peptide precursors have been shown to consist of a N-terminal proregion similar to a protein named cathelin and a structurally varied C-terminal antimicrobial domain. Proteins with these features have been named cathelicidins. In this paper we report the cDNA sequences of three ovine cathelicidins of 155, 160 and 190 residues, respectively, with cationic C-terminal sequences corresponding to putative antimicrobial domains. These are structurally varied and include a Cys-rich sequence of 12 residues, which is similar to the bovine antimicrobial cyclic dodecapeptide, a novel 29 residue sequence named SMAP-29 with a possible alpha-helical conformation, and a 60 residue sequence named Bac7.5, which appears to be a new member of the Pro- and Arg-rich group of mammalian antimicrobial peptides.


Q:

SQL Server query that takes time

For a recent test, I want to 'create' a query which takes atleast 5 seconds to execute and does not change the schema or data of the database - although I can create a table and then delete it. Till that level its ok . How can I do this?

A:

Use the WAITFOR command:
WAITFOR DELAY '00:00:05';

to romp through Premier League defences. Both Benzema and Lewandowski are proven at the highest level and could add much-needed physicality to a forward line that can be dominated in combative contests.

Giroud passes and moves well, but he cannot be considered a top-level finisher. The same can be said of Walcott, whose pace allows him to latch on to through balls and toward the opposition's defence in a flash. Like Giroud, his Gunners career is defined by two concurrent notions: he's a potential match-winner who doesn't show this quality enough.

Benzema is used to bringing wide men into play, so he'd be a natural fit. Lewandowski is more prone to skipping beyond defenders with the ball, but he can also effectively work the hold-up man role if needed.

Wenger may


How not to deal with customer feedback - jancona
http://attepicfail.tumblr.com/

======
paulgb
What did he expect? He contacts the CEO, knowing that it's _not_ going to be
read by the CEO, but his support staff at best, and _directly insults_ the
support staff ("$12/hour Executive Relations college students")

They didn't even send him a form letter C&D, they just warned him that if he
kept pestering the CEO of a major corporation with his personal issues, they
would.

Judging by the name calling he does in the letter, I would guess the executive
relations staff had already politely implied that he shouldn't be contacting
them.

Never thought I'd be saying this, but: I'm siding with AT&T on this one.

------
wooster
He should send a cease and desist letter to AT&T telling them not to have
their Executive Response Team call him again.

He _did_ specificallythreats of violence from his supporters.

The verdict was announced by Judge Madhusudan Sharma inside the Jodhpur Central Jail, which has been closed to even the media. As a precaution against any violence from his supporters, authorities have positioned extra security at the jail as well as across four states - Rajasthan, Uttar Pradesh, Haryana and Gujarat.

The two other people convicted in the rape got twenty years each in prison.

It sounds ridiculous that there are thousands of people out there who support a rapist and criminal, in no other civilised society would anyone even own up to supporting someone like that.

Image: FirstPost

Rape is not the only crime he’s been accused of. Asaram faces another case in Surat, Gujarat, where two sisters have accused him and his son Narayan Sai


remains. The actuator piston is provided with a check valve, which permits uninhibited communication across the piston in one direction, and restricted communication in the other direction. Accordingly, when the vacuum signal increases to a predetermined amount more than that required to actuate the valve, the actuator piston will deflect, thereby actuating the valve element, for a few seconds until the pressure is equalized across the actuator piston, and thereafter will return to a position communicating the air supply to the upstream injection point.Getting Started

We asked Larry and Patty Morehead, former missionaries in Bolivia, to speak a little about their experience on the field, as well as their perspectives on short-term mission trips, how to use diverse talents, and how the Lord played apart in their time in Bolivia. Here are Patty's thoughts.

You have your part in the Great Commission

My name is Patricia (Patty), I was born in Santa Cruz, Bolivia in the heart of South America.

God has blessed me with an extraordinary husband, Larry, who loves God with all of his heart, all of his mind and all of his will. Not only that, but he serves in missions and is willing to do so for the rest of his life, (something I obviously made sure of before going out


see everything with your own eyes. Since 2006, hundreds of people have joined us on our Cycling Study Tours.
First hand experience is better than reading. Book a tour to see how policy and infrastructure have attracted people from all walks of life to cycle:

Support this blog

Thousands of hours of work have gone into compiling the information on this blog but we do not receive grants and we do not ask for charity to support us.

You can help to make further blog posts possible by buying proven bicycle components from us:

Copyright and Licensing

This blog is free of charge to read and for most individual usage including reasonable "quoting" of its contents. However, neither the text nor the photos on this blog are in the public domain. To find outbias field and gas puffs are introduced, negative polarity high-voltage is applied to the inner electrode by discharging a 120$~\mu$F capacitor bank through an ignitron; the outer electrode is maintained at vacuum chamber ground. In the presence of the high-voltage, the neutral hydrogen breaks down. The optimum path for breakdown is along vacuum field lines linking the inner and outer electrodes as shown in Fig. \[gun\_flux\]. The gun voltage ${V_{\rm gun}}$ drives a current ${I_{\rm gun}}$ between the electrodes, twisting up the purely poloidal vacuum field and producing a ${B_\theta}$. In an accretion disc, it is the disc rotation which achieves the same effect. The initally discrete flux tubes expand and eventually merge into an axisymmetric configuration. Throughout this process, magnetic helicity is being injected from the gun into


${I_{\rm gun}}$ are fully contained inside the plasma column, and using the definition of ${\alpha_{\rm gun}}$ and ${\psi_{\rm gun}}$, it is straightforward to show that the condition for stability is $${\alpha_{\rm gun}}L < 4\pi.$$ Figure \[KS\] plots ${\alpha_{\rm gun}}$ versus $L$ for a collection of central columns taken from both different discharges and different times from within the same discharge. Stable (triangles), marginally unstable (squares), and kinked (diamonds) columns are plotted in ${\alpha_{\rm gun}}$–$L$ space, along with the Kruskal-Shafranov stability threshold (dashed line), showing good agreement between experiment and theory. This result indicates that plasma instabilities, in this case an ideal kink, can give rise to macroscopic structure within jets.

![A plot of ${\alpha_{\rm gun}}$ versus column length $L$ for different plasmas, showing good agreement with the Kruskal-Shafranov condition fora current-driven kink instability.[]{data-label="KS"}](fig5.eps){width="3truein"}

Detached plasma: an analog for disc flares
------------------------------------------

Still higher values of ${\alpha_{\rm gun}}$ result in detached plasmas, as shown in Fig. \[1181\_sequence\], in which ${\alpha_{\rm gun}}$ peaks at approximately 129 m$^{-1}$. In this discharge, the plasma appears to detach from the electrodes in frame (d) and then propagates along the $Z$ direction at a speed of approximately $6\times 10^4$ m/s, a fraction of the estimated ${V_{\rm A}}$. It is likely that a spheromak configuration is formed here; this was verified previously with direct measurement of ${{\bf B}}$ on an experiment with a non-planar source but similar helicity injection (Yee & Bellan 2000). This result supports the idea of field line reconnection above accretion discs, which can lead to disc winds and also episodic high energy flaring.

![image](fig6.eps){width="6truein"}

Discussion
==========

The results above show three


stated, "[i]n order to apply extraterritorially a federal criminal statute to a defendant consistent with due process, there must be a sufficient nexus between the defendant and the United States." Defendant argues the application of § 1119 to her is "unreasonable, arbitrary, and fundamentally unfair" because "[t]he alleged conduct had no link to the United States." See Def.'s Mot. to Dismiss, filed August 21, 1997, at 11. Therefore, Defendant suggests the prosecution is inconsistent with due process principles because the alleged acts "did not take place within the United States or have any effect on the United States." Id.
Contrary to Defendant's assertions, no due process problem is presented here. First, where the government seeks to prosecute a United States citizen for acts occurring in foreign lands, due processproteins can generate functional recombinants, although not all combinations are tolerated. The noteworthy mechanistic implication of the above discussion is that specific combinations of different structural motifs can be assembled in order to generate a functional FAST protein \[[@B3-viruses-12-00702],[@B40-viruses-12-00702]\].

The modular nature of FAST proteins and the diversity of the functional motifs that they employ to drive membrane fusion raises interesting questions regarding the evolution of these non-enveloped virus fusogens. Previous phylogenetic studies that included the six available sequenced species of orthoreoviruses suggested two separate gain-of-fusion events caused by a common ancestral, non-fusogenic reovirus led to the extant fusogenic aqua- and orthoreoviruses \[[@B2-viruses-12-00702]\]. The evolutionary relationship between the orthoreovirus FAST proteins was unclear. These studies also overlooked the waterfowl subgroup of ARV typified by the Muscovy duck reoviruses (MdRV).


at 4 °C. Cells were thoroughly washed with PBS and then incubated with 1:1000 dilutions of Alexa 488-conjugated goat anti-mouse antibody and Alexa 555-conjugated goat anti-rabbit antibody for 1 h at room temperature. Coverslips were then mounted using prolong gold anti-fade reagent (Invitrogen) and imaged using a Zeiss LSM510 Axiovert 200M confocal microscope.

2.6. Cell Surface Biotinylation {#sec2dot6-viruses-12-00702}
-------------------------------

QM5 cells grown in 10 cm dishes (Corning) to 50% confluency were transfected with the indicated FLAG-tagged constructs. At 24 h post-transfection, cells were washed three times with ice-cold PBS (pH 8.0), then incubated with shaking in 1 mg/mL Sulfo-NHS-LC-Biotin (a membrane impermeable biotinylation reagent) for 2 h at 4 °C to biotinylate primary amino groups on the cell surface. Cells were washed with PBS containing 100 mM glycine to quench andsignificantly reduced or is undetectable in 92% (11/12) of the ovarian tumors and tumor cell lines analyzed. The location, high degree of amino acid conservation, and reduced expression in ovarian tumors and tumor cell lines suggest that decreased expression of these two genes contributes to ovarian tumorigenesis and should be considered candidate tumor suppressor genes.


state lawmakers are motivated to support education issues, says Priest. Parents can be effective advocates when supporting programs proven to raise student achievement.

Beware the enemy within. Be cautious of attitudes that impede moving advocacy and the profession forward. Don’t complain during strategy sessions or in front of supporters.

Use data. Lawmakers have limited time to study issues. Help them with objective studies and data to support proposals. If groups are arguing about the veracity of a study, legislators may turn down a request for support, Priest says.

Understand limits. Even in times of plenty, legislatures and school boards have limited funds, and school districts are not funded equally. Proposals emphasizing student improvement and efficiencies are more likely to get a green light.

Keep a positive message. Give advocates talking points forthe moms and WLMA have built on those beginnings by reexamining the role of the profession, and using their mission itself as an effective advocacy tool.

Beyond appliqué sweaters

“What the Spokane moms started was the critical reexamination of the role the school librarian has in 21st-century schools,” says Mark Ray, Vancouver Public School’s director of instructional technology and library services and SLJ’s “Pivot Points” columnist. “Since then, WLMA has really worked on clarifying and defining what that looks like and the roles we need to play to support student learning.”

These efforts built on work begun in 2005. That year, WLMA leaders thwarted a move to eliminate school librarians from the state’s Common School Manual, a compilation of administrative rules governing school operations. WLMA leaders realized that education policy makers


ALA’s Michael L. Printz Award Committee almost lost her job, says, “It seems like every year when they talk about budgets, librarians are considered.”

Marta Murvosh, MLS, is a recovering journalist who works for a regional library system in Northwestern Washington, where she connects patrons to information, resources, technology, and books. You can follow her at www.facebook.com/MartaMurvosh.

This article was published in School Library Journal's October 2013 issue. Subscribe today and save up to 35% off the regular subscription rate.

Our newest installment of Maker Workshop will feature up-to-the-minute content to help you develop a rich maker program for your school or library. Join us to learn new ways of sparking engagement and hands-on learning directly from experts doing inspiring work that you can emulate, regardless of your library’s size orTag: Risk Assessment

Google has expelled 20 Android apps from its Play marketplace after finding they contained code for monitoring and extracting users’ e-mail, text messages, locations, voice calls, and other sensitive data.

The apps, which made their way onto about 100 phones, exploited known vulnerabilities to “root” devices running older versions of Android. Root status allowed the apps to bypass security protections built into the mobile operating system. As a result, the apps were capable of surreptitiously accessing sensitive data stored, sent, or received by at least a dozen other apps, including Gmail, Hangouts, LinkedIn, and Messenger. The now-ejected apps also collected messages sent and received by Whatsapp, Telegram, and Viber, which all encrypt data in an attempt to make it harder for attackers to intercept messages while in


into a light source accommodating space of the backlight module. Accordingly, in fabricating such a backlight module, the LEDs must be previously welded to the circuit board. Then, the circuit board, together with the LEDs welded thereon, is secured to light source accommodating space of the backlight module. As such, the process of the fabrication is relatively complex, and needs a high fabrication cost.Students at the Lilla G. Frederick Pilot Middle School work on their laptops during a class in Dorchester, Massachusetts in this June 20, 2008 file photo. REUTERS/Adam Hunger

NEW YORK (Reuters) - Children are using the Internet to watch YouTube videos, connect with friends on social network sites and look up “sex” and “porn,” according to a study of the top Web searches by youngsters.

Computer security firm Symantec Corp identified the top 100 searches conducted between February and July through its family safety service OnlineFamily.Norton, which monitors children’s and teenager’s Internet use.

It found the most popular search term was for YouTube, the video sharing website owned by Google, with Internet star, Fred Figglehorn, a fictional character whose YouTube videos are popular with children, coming ninth in the top searches.

The


which satisfies: $$T_{c}\ll\triangle t\ll T_{r}$$ where $T_{c}$ and $T_{r}$ are the crossing time and the relaxation time, respectively. The halo evolves accordingly. The relaxation time is related to the crossing time ([@bin87]): $$T_{r}/T_{c}\propto N/\ln N$$ And the crossing time can be calculated as a function of the total mass M and the total energy $\varepsilon$ of the system ([@van68]): $$T_{c}=CGM^{5/2}|\varepsilon|^{-3/2}$$ where C is a numerical constant.

Neglecting the fluctuating field in a first approximation, the motion of the particle is governed by the main spherical symmetry field which changes with the density or mass distribution of the halo. The particle will then take a plane rosette motion ([@bin87]). In any given state the particle is characterized by its position, energy and its angular momentum. One could derive the statisticof the system by randomly choosing the new positions and velocities of the particles on their respective orbits. Taking them as the new conditions, we can calculate a new density (or mass) distribution and accordingly a new potential of the system, which will in turn determine the positions of particles at the next step. The equilibrium state of the halo can be tested by comparing the new density (or mass) distribution with the initial one. Due to this character, if we find some deviation from the initial state of a system at one step, the deviation should grow in the simulations until the system relaxes to a new stable equilibrium (as Figure \[DenProvsD\]b shows). In other words, what we could illustrate with the Monte Carlo method at the present


that the SSC in Model A experiences much stronger dynamical friction and loses angular momentum quickly at first. This situation is consistent with the velocity distributions that we discussed above. In fact, in an isotropic halo, the effect of the dynamical friction comes from the DM particles whose velocities are less than that of the SSC ([@bin87]). As we illustrated in Figure \[VelDisvsDisCen\], the true velocity structure in the inner part of the halo is more peaked than a Gaussian. Thus more particles with low velocities exist, resulting in stronger dynamical friction on SSC. Inside 200 $pc$ from the center, the SSC in Model A sinks slowly than that in Model B, mainly due to its low velocity and low deceleration accordingly.

(10.8cm,8.8cm)[fig3.eps]{}

A similar sinking story is presented in Figure \[TrajTo\]b)
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Copyright Â© 2001-2004 World Wide Web Consortium,
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for Informatics and Mathematics, Keio University). All
Rights Reserved. This work is distributed under the W3CÂ® Software License [1] in the
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the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.

[1] http://www.w3.org/Consortium/Legal/2002/copyright-software-20021231
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to be punished, but also as a sin to be overcome by one and forgiven by another.

We have both modern and ancient examples of forgiveness for terrible acts against humanity – from the inspiration of young Malala to the courage of Jesus. Both knew and employed the power of forgiveness in the healing process.

These stories of personal triumph show that forgiveness begins within; so, ultimately forgiveness is a gift we give to ourselves. Many profound spiritual thinkers through the ages have known this. Christian healer and author Mary Baker Eddy wrote: ‘One’s first lesson is to learn one’s self; having done this, one will naturally, through grace from God, forgive his brother and love his enemies.’ (Miscellaneous Writings, p. 129)

One of the two great Christian commandments asks thatthat you got back in the saddle." "It's a sativa, dude." "It'll lift your spirits but not knock you out." "Just do it... it's nothing." "Okay." "(BUBBLING)" "(GAGGING, COUGHING)" "(COUGHING)" "(COUGHING)" "(RASPY COUGHING)" "(LAUGHTER ECHOING)" "JOE:" "I love you." "BETH:" "I love you too, Joe." "(LAUGHING)" "Sweet Jesus." "Wait." "Oh no." "(SHOUTING)" "Fuck me." "Aye, Sir Dragoroth have been detained by Minerva." "...The sea hag." "His bewitchment by the siren's song shall be the nail thine army wantst, King Diamond the Red." "We shall see." " Until Evermore." " 'Til Evermore." "Eric!" "Hung!" "Where the fuck are we?" "'Tis the kingdom of Eliphaz, my naive friend." "(HORN HONKING)" "You shanghaied me and dressed me." "Aye." "It just felt right." "Adventuring is exactly what thou needst." " "Needst" is


"And there be monsters in need of pummeling'!" "You have a choice:" "Join us in tasting the sweet nectar of victory or mope around an empty house all week like a bitch." "You guys do actually look slightly badass." "It's like a Metalwolf cover." " Yeah." " Without the muscles." "No." "(SIGHING)" "All right." "I'm in." "BOTH:" "Huzzah!" "Please." "Don't make me rethink this." "Nah." "(CLANGING)" "Welcome to the fields of Evermore!" " Um, Ronnie?" " Yes, Travis." "Where are our costumes?" "♪ There is no end to the tricks up my sleeve ♪" " Wardr'be?" " MAN:" "Yes, sir." "Got it... 42 regular." "RONNIE: 42 reg..." "I think you'll find it snug." " Great." " RONNIE:" "Freshly laundered." "I'm a trained actor, man." "Not some fucking... stuntanimation spell." " Ready?" " Oh, for God's sake." "(RECITING FOREIGN LANGUAGE)" "(RECITATION BECOMES MORE HIGH PITCHED)" "(LAUGHING)" "(HIGH-PITCHED, ETHEREAL HUMMING)" "(WINDS HOWLING)" "(NEBULOUS YOWLING)" "(GASPING)" "(DEMONIC HOWLING) Ahh!" "Beth?" "Beth?" "Ahh!" "(RECITATION CONTINUES)" "(WHOOSHING)" "(GAGGING, COUGHING)" " How awesome was that!" " A-plus, motherfucker." "Arise, Jobreyth." "Breathe fresh the air once again." "(COUGHING)" "What the fuck was that... it hurt." "(GAGGING COUGHS)" "Methinks you should not be so much of a pussy." "Don't tell me you've never played with fireworks before." "Not like that." "What was with the faces, the smells, everything?" "What was that?" "I tell you what I see." "A warrior... who can't let go of his past." "JOE:" "What are you doing?" "Wow." "What was that?" "Ex-girlfriend!" "Jobryeth needeth closure!" "It's not like that."


who are our comrades, Enchanter?" "Right." "That be Lando, the pious." "Watch him in battle..." "Complete weasel, but entertaining." "You'll see." "Sir Gunther, the mighty." "Head case with a big stick." "He is unique and crazy." "JOE:" "And..." "ERIC:" "And Guinevere the fearless, who's plus-three ass perfection should keep the memory of She Who Shall Not Be Mentioned at bay." "Plus-three?" "Clearly you underestimate my endowments." "(MONKEY-LIKE GRUNTING AND WHOOPING)" "Look, your party has disturbed a nest!" "Demon apes!" "What the fuck?" "Play on!" "One of the beasts deals Sir Hung the Glutinous a stunning blow!" "(LAUGHING AND GRUNTING)" "LANDO:" "Haha!" "Great way to spend the weekend." "Sweating my balls off in a monkey outfit." "I don't know where the hell I am." "(PINES CRACKING)" "Wha..." "Who's there?"at least you're supporting your boyfriend's interests." " A lot of girls..." " Boyfriend?" "God, no." "Gunther's my cousin." "He's a good kid, but he never breaks character." "Whoa, whoa, wait." "He never breaks character?" "He truly believes he's in another time and a place." "(LAUGHING)" "But his folks don't let him come to these things alone." "So you're warrior-sitting then?" "Well, after the Medieval Times incident," "I seem to be the only one he listens to." "The Medieval Times incident?" "Mom thought it would be cute to take him there." "He jumped the wall and sent the Red Knight to the hospital." "(LAUGHING)" "Sorry." "Not funny." "(GROWLING)" "I've got this." "(GROANING)" "Ooh!" "Um, miss." "JOE:" "The fuck?" "Spell of protection." "It's too late." "Drop." "To the nether


not gonna sing, Joe, are you?" " What?" "Tell me you're not gonna sing." "Not right now, baby." "No, no, no." "No, no, no, no!" "GWEN:" "Gunther!" "Gunther!" "Ease up!" "Stay your hand, mighty warlord." "Evil has befallen him." "His handiwork is all around us." "We heard you and we thought it might be whoever... did this." "Where's... where's Ronnie?" "Lando?" "Do not enter." "One cannot cheat death forever." "(DRIPPING)" "This is not good." "Joe, what the fuck is going on here?" "I don't know what's going on." "But I want to talk to Ronnie." "Ronnie?" "You think Ronnie is responsible for this?" "What am I supposed to think?" "You guys and your quest for authenticity." "Oh, come..." "Real weapons." "In-game bullshit." " Archaic books." " Ugh, thegoing on..." "Wait a minute, LARP like, like dressed up" " like wizards and shit?" " Yeah, like that." "But this is serious." "It wasn't just one of those paintballer pranks, people are in danger." "You stay put..." "We'll be right there." "Oh, thank god." "Tommy!" "Tommy, get your ass up." "We gotta get going." "(PHONE DIALING)" "Hey, Randy." "Rise and shine, buddy." "We got a cold dish of get back that needs serving." "Get your cousin and get your gear." "Imma pick you up in 10." "MAN:" "Whoa, this does not look like regulation game play." "Are you guys out of game or not?" "We're so far outta game, we're somehow back in it." "I thought you said there were bodies." " What are you guys up


summoned demons and the demons forged this book." " What are you saying, Kwok?" " Dee tried to destroy, but he couldn't." "So he sealed it and he hid it deep underneath his manor estate and it has been lost for generations." "But here it is in your incapable hands and you summoned a succubus from hell!" "(PAINED HOWLING)" "And then this last passage that you read, the herald of Abominog." "And in the language lay the name of the hell lord Abominog and I hath spoken the name and hell hath raineth down." "(GROWLING)" "You didn't injure it, you ignorant fuck!" "You transformed it!" "Sorry." "Transformed into what exactly?" "(POUNDING AND RUMBLING)" "(DISTANT UNEARTHLY YOWLING)" "(GASPING)" "What?" " MAN:" "What the fuck was that?" " I don'tenough damage already." "You... that thing..." "That's real!" "That thing slaughtered our best friend." "You gonna let that stand?" "You been out here practicing this shit every weekend for years." "Face it, man." "You've got everything but you earned nothing." "Are you gonna hide from that then?" "The way you hide from real life?" "Or are you gonna man up and avenge the death of our friend?" "The time has come to earn our valor, people." "(SWOOSHING)" "(CLICKING)" "(HISSING)" "For Hung." "(ENGINE RUMBLING)" "ANNOUNCER:" "Steel thyselves, adventurers." "The time for battle is nigh." "The fate of the glorious kingdom of Evermore rests in the balance." "Two armies fighting for one prize..." "bragging rights on the Evermore LARP Alliance message board." "Diamond starts speech." "He rouseth the troops." "I


Q:

aplay piping to arecord using a file instead of stdin and stdout

Below command will record the data from default device and output it on stdout and aplay will play the data from stdin.
arecord -D hw:0  | aplay -D hw:1 -

Why we prefer stdin and stdout instead of writing into a file and reading from it as below?
arecord -D hw:0 test.wav | aplay -D hw:1 test.wav

A:

Using a pipe for this operation is more efficient and effective than using a file, simply because of the following reasons:
1) Pipe (|) is an interprocess communication technique. The output of one process is directly sent to the input of another process using a kernel-based buffer. So this gives faster speed than writing something to a file in hard disk and reading itare used, the assembler has the task of ensuring each pinion gear has a total of four washers. If four pinions are mounted in the cage, the assembler must account for sixteen washers. If a single washer is omitted, at least one pinion of the planet carrier must be disassembled so that the washer can be installed. Since the pins are swaged at assembly, a new pin is required when the pinion is reassembled.
When a single washer is installed on each side of each pinion gear, the cost of additional machining increases the cost of the carrier assembly. Each cage sidewall must be inspected to ensure that the machining has been accomplished prior to assembly of the cage. When two washers are used on each side of each


ARLINGTON, Texas -- Frank Lucchesi, who replaced the fired Billy Martin as manager of the Texas Rangers in 1975 and was punched by a player upset over a demotion two years later, has died. He was 92.

The Rangers said Lucchesi died Saturday. The San Francisco native lived in the Dallas area.

Lucchesi managed in the minor leagues for 17 years before taking over in Philadelphia in 1970. He managed the Phillies for two full seasons and part of a third in 1972. He was a coach for the Rangers when he replaced Martin and managed Texas all of 1976.

During spring training in 1977, second baseman Lenny Randle was upset over being benched and punched Lucchesi, sending him to the hospital. Lucchesi was fired during the season with the Rangersbut no gid mappings found.")
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		}
		return id, nil
	}
	// Return unchanged id.
	return containerId, nil
}

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func (c Config) HostRootGID() (int, error) {
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			hostID := m.HostID + (containerID - m.ContainerID)
			return hostID, true
		}
	}
	return -1, false
}


55*m**2 + 56. Let g(w) = 15*r(w) + 4*x(w). Differentiate g(a) wrt a.
-110*a
Let w(u) = -u**3 + 8*u**2 - 12*u + 7. Let j be w(6). Let h(t) = 2*t - 10. Let l be h(j). Differentiate 6 - 1 + 1 + l + 2*g wrt g.
2
Let z = 178 - 51. What is the third derivative of -2*y**3 - 10*y**2 - 127 - y - 34*y**4 + z wrt y?
-816*y - 12
Find the third derivative of -795 - 6*i**3 - 7*i**6 + 178*i - 3*i**5 + 52*i - i**2 + 792 + 26*i**3 wrt i.
-840*i**3 - 180*i**2 + 120
Suppose 19 = 6*u - 5. Suppose 99 - 111 = u*r. Let l(d) = -6*d - 38. Let y(q) = -4*q - 37. Let t(c) = r*y(c)1. Introduction {#sec1-sensors-19-02463}
===============

As basic electromagnetic devices, inductors are widely used in circuit design and signal processing \[[@B1-sensors-19-02463],[@B2-sensors-19-02463],[@B3-sensors-19-02463]\]. Inductance is the circuit parameter used to describe an inductor, which relates the induced voltage to the current. However, the conventional practical inductors are usually made up of coils and magnetic cores. It is always difficult to implement a practical inductor with large inductance value and small physical size. Besides, the inductance value of a practical inductor can't be adjusted easily. Even for the practical adjustable inductor, its adjustment range is usually less than 15%.

The simulated inductor technique was developed and studied to replace a practical inductor effectively in the research field of integrated circuits \[[@B3-sensors-19-02463],[@B4-sensors-19-02463],[@B5-sensors-19-02463],[@B6-sensors-19-02463],[@B7-sensors-19-02463],[@B8-sensors-19-02463],[@B9-sensors-19-02463],[@B10-sensors-19-02463],[@B11-sensors-19-02463],[@B12-sensors-19-02463],[@B13-sensors-19-02463],[@B14-sensors-19-02463]\]. A simulated inductor is an active circuit for generating an equivalent inductive reactance, which is


it will be of great significance if we can seek an effective approach to develop a new kind of simulated inductor which combines the advantages of the two conventional simulated inductors mentioned above and overcomes the existing disadvantages of each type. That would extend the application fields of the simulated inductor technique and satisfy the wide requirements of an inductor (or inductor module) with large inductance value, wide adjustable range of inductance value and small size.

Currently, contactless electrical tomography (CET) has received increasing attention in the field of process tomography \[[@B16-sensors-19-02463],[@B17-sensors-19-02463]\]. The latest research progresses have displayed the potential and broad perspective of the contactless electrical tomography (CET) techniques \[[@B18-sensors-19-02463],[@B19-sensors-19-02463],[@B20-sensors-19-02463],[@B21-sensors-19-02463],[@B22-sensors-19-02463],[@B23-sensors-19-02463],[@B24-sensors-19-02463],[@B25-sensors-19-02463],[@B26-sensors-19-02463],[@B27-sensors-19-02463]\]. However, the current CET systems still exist a drawback, i.e., the existence of the coupling capacitances (formed bythe two electrodes, insulating pipe, and the measured fluid) are adverse to the detection of the useful measurement signal (the details will be discussed in [Section 5](#sec5-sensors-19-02463){ref-type="sec"}). Research works have verified that the impedance elimination principle can provide an effective approach \[[@B28-sensors-19-02463],[@B29-sensors-19-02463],[@B30-sensors-19-02463],[@B31-sensors-19-02463],[@B32-sensors-19-02463]\], i.e., by introducing an inductor module, using the inductive reactance of the inductor module to eliminate the capacitive reactance of the coupling capacitances. However, that needs large-value and adjustable independent inductors. The emergence of simulated inductor technique provides an effective approach to solve this problem. Unfortunately, at the current stage, our knowledge and experience on applying simulated inductor technique to the field of process tomography is limited. More research work needs to be undertaken.

This work aims to report a new simulated inductor which is suitable for


floating simulated inductor, respectively. For both Riordan simulated inductors, the circuits input impedance $Z_{in}$ both behave as an equivalent inductance $L_{eq}$, i.e.,:$$Z_{in} = \frac{u_{in}}{i_{in}} = j2\pi fL_{eq}$$ where $f$ is the frequency of the excitation signal and $j$ is the imaginary unit.

The Riordan grounded simulated inductor has a simple circuit structure, as shown in [Figure 1](#sensors-19-02463-f001){ref-type="fig"}a. One of its terminals must be grounded directly. The Riordan floating simulated inductor uses two Riordan grounded simulated inductors which are connected in cascade (back to back), as shown in [Figure 1](#sensors-19-02463-f001){ref-type="fig"}b. It has a symmetrical circuit structure. Its terminals need not to be grounded directly. It can be regarded as an independent module (like a practical inductor) and be connected to the required position of an electrical circuit freely.

The detailed discussionsorder to adjust the value of $L_{eq}$ and $r_{eq}$ conveniently and independently, the values of $R_{2}$, $R_{3}$, $R_{5}$ and $C_{m}$ are fixed. The value of $L_{eq}$ is mainly adjusted by changing the value of the high-precision adjustable resistor $R_{1}$, while the value of $r_{eq}$. is mainly determined by the value of $R_{4}$. Because the equivalent internal resistance of an inductor module should be as small as possible, the value of $R_{4}$ is usually much larger than those of $R_{1}$, $R_{2}$, $R_{3}$ and $R_{5}$, respectively.

It is necessary to indicate that the value of the $L_{eq}$ is affected by $R_{5}$. In practical applications, the value of $L_{eq}$ is expected as a constant, which means the value of $R_{5}$ should also be a constant. That is the reason why one terminal


Meanwhile, the common node ($u_{com}$) of the independent power is connected to the output terminal.

From [Section 2](#sec2-sensors-19-02463){ref-type="sec"}, the output terminal of the Riordan grounded simulated inductor needs to be grounded, to ensure that the simulated inductor module has a fixed equivalent inductance value $L_{eq}$ (as discussed in [Section 2.1](#sec2dot1-sensors-19-02463){ref-type="sec"}, the pre-condition to obtain a fixed value of $L_{eq}$ is that the load of the circuit is fixed). However, in practical applications, changes of the succeeding circuit should not affect the inductance value $L_{eq}$ of an independent inductor module. Therefore, as shown in [Figure 4](#sensors-19-02463-f004){ref-type="fig"}, an equivalent grounded method is introduced to meet the application pre-condition of the Riordan grounded simulated inductor, i.e., connecting the output terminal to the inverting input terminal of an operational amplifier, and the noninvertingsix kinds of RC series combinations were formed by resistors of 20.16 kΩ, 47.58 kΩ, 76.65 kΩ and capacitors of 5.52 pF, 15.32 pF.

The true values of the resistors and the capacitors were calibrated by a commercial impedance analyzer (Keysight 4294A, Santa Rosa, CA, USA, 40 Hz to 110 MHz) at 250 kHz. The AC excitation signal was generated by a digital signal generator. The AC excitation signal had the amplitude value of 1.52 V and its frequency is 250 kHz. The total impedance information was measured by the signal processing module.

To test the performance of the measurement, four performance indexes are selected, including $e_{R}$, $e_{C}$, $\sigma_{R}$ and $\sigma_{C}$. The $e_{R}$ and $e_{C}$ are the relative errors (%) of the resistance measurement and the capacitance measurement. $\sigma_{R}$ and


the measurement results of Group 1 and Group 2, respectively. The maximum relative error of the resistance measurement $e_{R}$ was 2.15%. The maximum relative error of the capacitance measurement $e_{C}$ was 2.99%. The maximum standard deviation of the resistance measurement was 0.50 kΩ. The standard deviation of the capacitance measurement was 0.05 pF.

[Table 1](#sensors-19-02463-t001){ref-type="table"} shows the experimental results of the impedance measurement experiments (Group 3). From [Table 1](#sensors-19-02463-t001){ref-type="table"}, it can be seen that the CET system based on the new simulated inductor module can effectively obtain the total impedance information. The maximum relative error of the impedance measurement of RC series combination was 4.77%. The maximum standard deviation of the resistance measurement was 0.27 kΩ. The maximum standard deviation of the capacitance measurement was 0.07 pF.

Correspondingly, in the
595 So.2d 1075 (1992)
Richard JASPER and WDR Financial Resources of New York, Inc., Appellants,
v.
Josh ZARA, M.D., Appellee.
No. 91-02323.
District Court of Appeal of Florida, Second District.
March 13, 1992.
Jonathan M. Fordin of James F. Dougherty, II, P.A., Miami Beach, for appellants.
Brian R. Worth of Beigel & Sandler, Ltd., Chicago, for appellee.
DANAHY, Acting Chief Judge.
Richard Jasper and WDR Financial Resources of New York, Inc., defendants in the trial court, appeal the denial of their motions to dismiss for lack of personal jurisdiction and to quash service of process. The appellee/plaintiff (Zara), a Florida physician, had invoked jurisdiction over these New York financial planners (Jasper) under subsections 48.193(1)(a), (1)(g), and (2), Florida Statutes (1989). Jasper contends that he had done no act, anticipated by the statute, to qualify him to be sued


in Florida. We agree and reverse.
The undisputed facts show that Zara solicited Jasper in New York by phone. Zara, in Florida, phoned Jasper in New York for financial advice and consultation because Jasper had been recommended to Zara by a friend of Zara's mother. After this initial solicitation by Zara, Jasper in New York communicated with Zara and his accountant by telephone and letter recommending various investment opportunities. Jasper recommended that Zara invest in two specific real estate limited partnerships; Zara did so based on this advice by Jasper. Unfortunately these two investments did not realize the financial advantages to Zara that Zara and Jasper had hoped for.
In his motion to dismiss and accompanying affidavits, Jasper claimed that he was a resident of New York, that he andshort or too long. A blocking-mode recv() or read() blocks for exactly the right length of time, and it's one line of code. If you want a socket timeout, set SO_RCVTIMEO.


AUC, *C*~max~ and *t*~1/2~. A *P*-value ⩽0.05 was considered significant.

Results
=======

General trial conduct
---------------------

Between July 2007 and May 2009, 20 patients were screened for inclusion in the trial. A total of 19 patients started treatment as one patient had a screening failure because of the appearance of clinically symptomatic brain metastases. Patient characteristics are summarised in [Table 1](#tbl1){ref-type="table"}. Three patients had early PD within the evaluation period of the first 50 days and were replaced as per protocol. One patient was not evaluated for DLT owing to incorrect medication intake by the patient herself. One patient (7%) received one cycle, nine patients (60%) received two cycles, three patients (20%) received four cycles and two patients (13%) received six cycles. No relation between number of cycles received and DLs was apparent.

Dose-limitingdose-limiting toxicities were serum transaminase elevations and PPE. Both toxicities have been reported before in combination strategies with mTOR inhibitors and VEGF(R) inhibitors ([@bib20]; [@bib2], [@bib3]; [@bib14]). However, for both sorafenib and sirolimus, serum transaminase elevations are not a frequently reported AE ([@bib4]). The timing of the rise in serum transaminases 2--3 weeks after start of the combination and the recovery after discontinuation of the combination, suggest a causal relationship. Vascular endothelial growth factor has a role in structural, functional integrity of the liver. Most consistently, growth stimulating, regenerative and cytoprotective effects of VEGF and a VEGFR agonist have been found in pre-clinical models of ischaemia and reperfusion-induced hepatic toxicity, indicating a causal relationship between VEGFR inhibitors and transaminitis ([@bib8]). Analysis of skin biopsies of PPE patients indicate


             0   0   32   6    2    0   1   47

Abbreviations: ALT, alanine transaminase; AST, aspartate transaminase.

###### Pharmacokinetics of sorafenib, expressed as geometric means with associated 95% CI

                                          **AUC~(0--12 h)~ mg h l^−1^ (95% CI)**   **C~max~ mg l^−1^ (95%CI)**                          so far away, I am 2.5 hours from my nearest one and ever time I go to visit friends in that city I beg and cry to go there too. I am also wanting the long desktop but I am opting for the storage ends, VIKA ANNEFORS. They're a little more, but my friend has one and her serger fits perfectly inside. I just love your blog, I am always sharing ideas from it with others. Thank you!