the blank group (P\<0.05; [Fig. 2C](#f2-etm-0-0-6492){ref-type="fig"}). Compared with the model group, TG and TCH were significantly decreased in the MHCD and telmisartan groups (both P\<0.05). These results indicate that MHCD ameliorates Doxorubicin-induced changes in ALB, Scr, TG and TCH levels in rats. Long-term proteinuria causes hyperlipidemia due to dysfunctional hepatic lipid protein synthesis ([@b17-etm-0-0-6492]). MHCD may improve lipid levels by reducing albuminuria in Doxorubicin-induced nephrotic rats. However, it is unclear whether MHCD can directly improve lipid levels.

### MHCD prevents glomerular and podocyte injury

As demonstrated in [Fig. 3](#f3-etm-0-0-6492){ref-type="fig"}, renal pathological changes were examined using HE, Masson\'s trichome and PAS staining. Compared with the blank group, the model group had a greater number of proliferative mesangial cells, increased extracellular matrix deposition, a thickened glomerular basement membrane and disorderly arranged tubularincluding focal segmental glomerularsclerosis, tubulointerstitial inflammation, fibrosis and podocyte fusion, typical of Doxorubicin-induced nephropathy, were also observed in the present study ([@b23-etm-0-0-6492]). In TCM, MHCD has been demonstrated to reduce urinary protein and cholesterol levels, increase serum albumin levels and prevent glomerular and podocyte injuries in Doxorubicin-induced nephrotic rats ([@b24-etm-0-0-6492]). These results may be used to develop novel methods for delaying glomerulosclerosis using TCM.

Autophagy is a process by which cellular components are recycled ([@b25-etm-0-0-6492]) and injured organelles and proteins are removed ([@b26-etm-0-0-6492]). Autophagy comprises mechanistically distinct steps, including the induction, identification and selection of cargo, the formation of vesicles, autophagosome vacuole fusion, the breakdown of cargo and the release of degradation products into the cytoplasm ([@b27-etm-0-0-6492]). The formation of autophagosomes serves an important role in autophagy and requires


of individual MHCD components in autophagy requires the synthesis of specific small molecule compounds for validation.

In the present study, it rats with untreated Doxorubicin-induced nephrosis exhibited a marked and sustained increase in proteinuria until week 6. In contrast, proteinuria in MHCD- and telmisartan-treated rats increased only slightly between weeks 2 and 4. Future studies should include a group of individuals treated with MHCD for 2 weeks prior to Doxorubicin treatment to further demonstrate that MHCD has protective roles in Doxorubicin-induced nephrotic rats. In conclusion, the results of the present study suggest that MHCD ameliorates proteinuria, increases ALB levels and decreases Scr, TG and TCH levels. Additionally, it protects against glomerular and podocyte injuries by inhibiting excessive autophagy via the PI3K/mTOR signaling pathway and upregulating basal autophagy.

Not applicable.

Funding
=======

The presentcan be re-published with appropriate attribution. For syndication rights, please write to publisher@newcanadianmedia.ca

Poll Question

Do you agree with the new immigration levels for 2017?

Featured Quote

The honest truth is there is still reluctance around immigration policy... When we want to talk about immigration and we say we want to bring more immigrants in because it's good for the economy, we still get pushback.


month.

So could Saara one day sing for the UK instead?

Saara wouldn't rule it out but did say it wasn't on the cards right now - what with her newly signed record deal with Sony Music following The X Factor.

"At this moment though I don't think it's the best move to do. Who knows one day I might represent the UK," she teased.

Meanwhile, speaking to BANG Showbiz, Saara revealed she remains in touch with her fellow X Factor finalists after last year's series.

She said: "Some of them came to my birthday party. We are all still quite close.

"I do have the judges phone numbers as well but I haven't seen them since leaving the show. When I release my music I will text Sharon Osborne and ask her aboutCOVID-19 cohorts and measured the association between each condition and disease complication by computing the corresponding odds ratio (OR) and its estimated statistical significance (using Fisher exact test). We conducted the analysis separately in three age groups (18-50 years, 50-65 years, and ≥65 years), as well as four (age, sex) strata (male or female; younger or older than 65 years). Using different age groups (as sensitivity analysis) obtained similar results. Finally, to account for multiple testing, we controlled for the false discovery rate using Benjamini and Hochberg's method \[[@ref19]\]. All analyses were performed using version 4.0.0 of the R programming language (R Project for Statistical Computing; R Foundation). We used the STROBE (Strengthening The Reporting of OBservational Studies in Epidemiology) cohort checklist when writing our report \[[@ref20]\].

Ethical Approval
----------------

The


individuals (N=442) and examined the association of existing conditions with disease severity; and the OpenSAFELY Collaborative explored the risk of COVID-19--related hospital death in the general population (N\>17 million). We emphasize that cohort composition dictates the research question it can address: our analysis focuses on SARS-CoV-2--positive individuals, hence searches for risk factors of complications in patients who already contracted the virus (but are potentially asymptomatic), while studying the general population may combine risk factors for infection and severe COVID-19 outcome. Additionally, cohorts that consider only a subset of patients, defined based on disease outcome (eg, symptomatic or hospitalized) or otherwise nonrepresentative of the entire population (eg, demographically skewed) may introduce biases to the analysis \[[@ref21]\]; instead, we study here all SARS-CoV-2--infected patients in a large, nationwide health organization.

Multipleanalysis.

CDC

:   Centers for Disease Control and Prevention

COVID-19

:   coronavirus disease

ECDC

:   European Centre for Disease Prevention and Control

MHS

:   Maccabi Health Services

MoH

:   Ministry of Health

NHS

:   National Health Service

OR

:   odds ratio

SARS-CoV-2

:   severe acute respiratory syndrome coronavirus 2

STROBE

:   Strengthening The Reporting of OBservational Studies in Epidemiology


other library
    or application that also has XZ Embedded in it (which may even be
    a different version of XZ Embedded). TODO: Provide an easy way
    to do this.

    Please don't create a shared library of XZ Embedded itself unless
    it is fine to rebuild everything depending on that shared library
    everytime you upgrade to a newer version of XZ Embedded. There are
    no API or ABI stability guarantees between different versions of
    XZ Embedded.

                        I

                Jury selection in this case began on January 30, 2012, and on April 3, 2012, the

jury returned its verdicts against co-Defendants Mark Pray, Alonzo Marlow, and Kenneth

Benbow. As related to Mr. Benbow, Count 1 charged a narcotics conspiracy involving large

quantities of phencyclidine (also known as PCP), cocaine, and cocaine base (also known as

crack); Count 2 charged a RICO conspiracy; Count 4 charged the murder of Van Johnson, Jr., as


shooting. Cell phone records established

that a cell phone known to be used by Mr. Pray was in contact with a cell phone known to be

used by Mr. Benbow during that time. From these facts, Mr. Benbow argues that “[n]o

reasonable trier of fact could ignore the obvious conflict [between] the testimony of Darryl

Travers and the undeniable phone records . . . and the government failed to offer any reasonable

explanation for the clear conflict.” Def.’s Mem. at 9. In other words, if Mr. Benbow and Mr.

Pray were talking by phone, it would have been impossible for Mr. Benbow to be also driving a

car at high speed while Mr. Pray was also shooting two guns as they passed their target. The

Government suggested in its closing argument that the phone connection mightinstruction to the jury on

multiple conspiracies, as requested by Mr. Benbow. Instructions requested by Mr. Pray were also

included in the Court’s oral and written instructions to the jury. However, the Court did not

submit to the jury the defense theories of the case prepared by Mr. Benbow or Mr. Pray and only

read them orally. Messrs. Benbow and Pray argue that this failure to include their theories of the

defense in the written jury instructions constituted error in violation of their rights to due process

and requires a judgment of acquittal or a new trial.4

               Jury instructions were discussed between the parties and the Court on multiple

occasions and the Court provided the parties with its proposed final Final


res (setf (aref *pr-sl* l) (float res)))
			    (setq complex t))))))
	 ;;this should catch expressions like sin(x)-x
	 (cpoly-err expr1))
     (setq *shr-sl* (make-array *nn* :initial-element 0.0))
     (setq *shi-sl* (make-array *nn* :initial-element 0.0))
     (setq *qpr-sl* (make-array *nn* :initial-element 0.0))
     (setq *hr-sl*  (make-array degree :initial-element 0.0))
     (setq *qhr-sl* (make-array degree :initial-element 0.0))
     (setq *qpi-sl* (make-array *nn* :initial-element 0.0))
     (when complex
       (setq *hi-sl*  (make-array degree :initial-element 0.0))
       (setq *qhi-sl* (make-array degree :initial-element 0.0)))
     (setq *nn* degree)
     (if complex
	 (setq res(do ((j 0 (1+ j))
	       (*e* (/ (* (cmod-sl (aref *qpr-sl* 0) (aref *qpi-sl* 0)) *mre*) (+ *are* *mre*))))
	      ((> j *nn*) *e*)
	    (setq *e* (+ (cmod-sl (aref *qpr-sl* j) (aref *qpi-sl* j)) (* *e* ms))))
	  (+ *are* *mre*))
      (* mp *mre*)))

;; Compute a lower bound on the roots of the polynomial.  Let the
;; polynomial be sum(a[k]*x^k,k,0,n).  Then the lower bound is the
;; smallest real root of sum(|a[k]|*x^k,k,0,n-1)-a[n].  For our
;; purposes, this lower bound is computed to an accuracy of .005 or
;; so.
(defun cauchy-sl ()
  (let ((x (exp (/ (- (log (aref *shr-sl* *nn*)) (log (aref *shr-sl* 0))) (float *nn*))))
	(xm 0.0))


DP, Dissen GA, Ojeda SR. Oocytes are a source of catecholamines in the primate ovary Evidence for a novel cell-cell regulatory loop. Proc Natl Acad Sci USA 95:10990-10995, 1998. Lawce M, Olson S, Wolf DP, Magenis R, Ellen R. Comparative mapping of human cosmid probes in rhesus monkey (Macaca mulatta) using fluorescence in situ hybridization. J Assoc Genetic Tech 24:37-43, 1998. Wolf DP, Meng L, Ely JJ, Stouffer RL. Recent progress in mammalian cloning. J Assist Reprod Genet 15:234-238, 1998. Smith GD, Sadhu A, Mathies S, Wolf DP. Characterization of protein phosphatases in mouse oocytes, Dev Biol 204:537-549, 1998. Mixon BA, Patton B, Wolf DP, Larson J. Pregnancy rates following intrauterine insemination (UI) with post-freeze processed vs. pre-freeze processed donor sperm. Fertil Steril (Suppl), p-605, 1998 (abstract #S-317).in Iraq and Afghanistan may have long-term health consequences to respiratory illnesses in the upper airways of Service Members. We initiated a study to characterize the upper respiratory microbiomes of healthy military personnel in a garrison environment in order to establish a baseline for future studies on the effects of specific activities and exposures on respiratory microbiota.

We previously conducted a preliminary study of laboratory and data processing/analysis procedures \[[@pone.0188461.ref013]\]. The methodology, which was established by using the microbial mock communities developed by the Human Microbiome Project (HMP), has been used to obtain results comparable or superior to those of other studies \[[@pone.0188461.ref014]\]. The workflow was applied to a pilot run of throat swabs collected from eight subjects \[[@pone.0188461.ref013]\]. Here, we used the same methods to study respiratory microbiota


in a larger group of military volunteers. This project aimed to characterize the composition and temporal variation of the normal military respiratory microbiota, identify individuals with abnormal respiratory bacterial taxa, collect comprehensive demographic data, and uncover associations between variables and profiles of respiratory bacterial communities.

Materials and methods {#sec002}
=====================

Sampling and DNA isolation {#sec003}
--------------------------

The study protocol WRAIR\#1914 and protocol amendment were approved by the Walter Reed Army Institute of Research (WRAIR) Institutional Review Board. Written, informed consent was obtained with signature from each participant. One Ultra-thin minitip flocked swab (dry tube, Catalog number 560C; COPAN Diagnostics Inc., Murrieta, CA) was applied to each of three anatomic sites: the anterior nares, oropharynx, and nasopharynx. The side from which the sample was collected was left to volunteer preference or chosen arbitrarily. Themicrobiome' ([Table 2](#pone.0188461.t002){ref-type="table"}). Both nasal and nasopharyngeal microbiota contained a high content of the same three genera---*Staphylococcus*, *Corynebacterium*, and *Propionibacterium*---which together constituted on average 77.4% and 75.6% of all OTUs classified to genus and OTUs classified to higher levels (shown as 'other' on [Fig 2](#pone.0188461.g002){ref-type="fig"}), respectively. In contrast, *Streptococcus* was the sole dominant bacterial genus in the oropharyngeal microbiota, although various other bacteria were also present but at much lower levels ([Table 2](#pone.0188461.t002){ref-type="table"}).

10.1371/journal.pone.0188461.t002

###### Major bacterial taxa of human respiratory microbiota.

Analysis of data (quarter S1 visit 1) from 36 subjects with samples available for all four quarters, showing the percentage of samples with a relative abundance of ≥0.5% or ≥1.0%. Data are shown in bold for percentage of samples ≥50%.

![](pone.0188461.t002){#pone.0188461.t002g}

  Bacterial genus


to the study. We thank Drs. Leonard N Binn, Stephen J Thomas, Leyi Lin, Hyun Jun Park, Tatsuya Oyama, and Mr. Tuan Nguyen for the technical support and/or critical reading of the manuscript.

16S rDNA

:   16S ribosomal RNA gene

HMP

:   Human Microbiome Project

OTUs

:   operational taxonomic units

QIIME

:   Quantitative Insights Into Microbial Ecology

RDP

:   Ribosomal Database Project

rRNA

:   ribosomal RNA

[^1]: **Competing Interests:**The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Army, DoD, or US government. JH, RCR, LRM, RGJ, JR, RAK and PBK are military service members (or employees of the U.S. Government). This work was prepared as part of their official duties. Title 17    leaf  external-lsa {
        type boolean;
        description
          "Override external-lsa metric with max-metric value";
      }
      leaf external-lsa-metric {
        type ospf:uint24;
        description
          "Overriding metric in external-LSAs (default 16711680)";
      }
    }
  }

  grouping  microloop-avoidance {
    description "Common node of default-vrf, vrf";
    container microloop-avoidance {
      description "Microloop avoidance configuration";


type uint32 {
          range "1 .. 255";
        }
        description "<1-255>;;OSPF Administrative distance";
      }
      leaf ip {
        type inet:ipv4-address;
        description "A.B.C.D;;IP source address";
      }

      leaf wildcard {
        type inet:ipv4-address;
        description "A.B.C.D;;Wildcard bits";
      }

      leaf acl-name {
        type access-list-standard-id-type;
       description "standard acl";
      }
    }
  }
  grouping max-lsa {
    description "Grouping for Max-LSA";
    container max-lsa-options {
      description "Option of Max-LSA";
      leaf threshold-value {
        type uint32 {
          range "1 .. 100";
        }
        description "<1-100> Threshold value (%) at which
          to generate a warning msg";


   if (!$first) {
                $compiler->write(" || ");
            }
            $first = false;

            $compiler
                ->write("isset({$this->rolesExpr}[")
                ->compileInternal($arg)
                ->write("])")
            ;
      can remain energetic after the age of 40.

Exercising on a regular basis:

With the help of exercise, you would be able to circulate blood all over your body. Since the blood circulation would be improved, the nutrient flow would also be improved. Moreover, you would feel less sleepy as well. That is why, if you do not exercise on a regular basis, you have to start now to ensure that the energy levels in your body are proper.

Cutting down on sugar consumption:

Sugar consumption just provides you with an impulse of energy. However, after the impulse, there is a drastic fall in the energy level. This results in bringing your energy levels down for the rest of the day. That is why, instead of consuming sugar thinking that it would


a few acres of trees and grass and one building?" "It must be some kind of illusion." "Negative." "It is as you see it." "Number One, I think you had better see who's at home." "Space, the final frontier." "These are the voyages of the Starship Enterprise." "Its continuing mission-- to explore strange new worlds to seek out new life and new civilizations to boldly go where no one has gone before." "If they're the only survivors of a nuclear holocaust they can't be in very good shape." "I understand." "Counselor?" "What I sense of them is human." "And something else?" "It's difficult to explain." "I feel there's something different about these two people." "I'm sorry." "I can't be clearer than that." "We're ready." "Good luck, Number One."USS Enterprise crew members." "May I come down and approach you?" "You leave him right where he is." "Should I incapacitate him, Commander?" "No." "We're a rescue party." "We picked up your colony's distress call and we came as fast as we could." "Kevin." "Kevin, what are you doing?" "Can't you see they're here to help us?" "Can't you see they're human?" "Go back in the house, Rishon." "This could be some kind of a trick." "We had almost given up hope." "We were afraid maybe the whole Federation had been attacked." "What about the colony?" "Do you know of any other survivors?" "It's been days since we've seen or heard from anybody." "No, don't." "Don't tell me that we're the only ones." "They came in a spaceship


so big you could see it in orbit." "They took our world apart piece by piece." "Who?" "We don't know." "We never saw their faces." "You don't know where they came from where they are now?" "I guess they've gone away." "Oh, I'm sorry." "I'm only performing a physical." "Could I have your names, please, just for the record." "I'm Rishon Uxbridge and this is my husband Kevin." "Botanists originally from the aquatic city" "New Martim Vaz, in Earth's Atlantic Ocean residents of the Rana iv colony for five years." "You, madam, are 82 years of age and a composer of Tao-classical music." "You, sir, are 85 years of age and a specialist in symbiotic plant life." "You have been married for 53 years." "I memorized the colonytalk with those two people." "You have the Bridge." "Reduce speed." "Bring us around on a return course." "This one's getting away." "Good afternoon." "I'm sorry if I startled you." "I'm Jean-Luc Picard, Captain of the Enterprise." "I have brought you something you will need if you're going to stay on Rana iv." "It's a matter replicator." "It has limited capabilities, but..." "Thank you, but we have no use for such a thing." "It will provide you with clothing, food and clean water." "Lieutenant Worf will demonstrate its operation." "We don't need it." "Kevin, you know we do." "Thank you, Captain." "Kevin and I were about to have afternoon tea." "You and Mr. Worf must join us." "I'd like that very much." "Rishon, they only want to spy


did nothing." "He is a very gentle man." "You must understand that." "What about you, Rishon?" "Is that how you feel?" "I wanted to fight, but I stayed with my husband." "Well, Captain, uh, thank you again for the replicator." "I better clean up now." "Before we leave, I ask you one more time to come to the ship." "For your own safety." "Captain, I am frightened, but..." "I can't leave Rana, even if it means my life." "I don't understand it." "I've inhibited almost all the activity of the neocortex and she continues to behave as if she's hearing the music." "We're going to have to shield her from all outside stimuli by inducing coma." "I have a positive identification, Commander." "It is the vessel that attacked"You'd better come see this." "Captain, Commander, the house is back." "Trees, grass, everything." "Happened right in front of us." "Mr. Worf, do you see any survivors?" "I detect two life-forms inside the house." "It appears Kevin and Rishon were not destroyed." "Helm, take us within transporter range." "We're going to beam them aboard directly onto the Bridge." "But, Captain, will they not protest?" "Let them." "My apologies if I interrupted a waltz." "Why have you brought us here against our will?" "I want to end the suffering of one of my crew members." "I don't understand." "Kevin does." "He's the cause." "At first, I couldn't understand why your house survived the holocaust when the others hadn't." "Then it occurred to me-- it had been destroyed." "That dwelling


extremely dumbfounded at the total lack of objectivity in the press and TV news(is he still alive and writing?) As I type this,I'm trying to pinpoint how it all got started.I know "All in the Family" referred to Walter Cronkite as" that pinko",but whenever I saw him,or Brinkley or others at the time,I never detected a liberal viewpoint(too young?) Much of this had to have started with Ronald Reagan--attacked at the time,as "dumb and unqualified"--similar to Trump is now. In fact all the Republican presidents were painted that way,though in "W" Bush's case--probably spot on--and the old man wasn't too swift either. On the other hand,Dems have had a free pass from the media going back to at least Kennedy--the only exception being Cronkites rebuke of LBJ's Vietname.g. the function returns text that is displayed in a label in the application).  The static library is included in the "Link Binary with Libraries" build phase of the application target.  Building from scratch causes the library to be built first, then the application, as expected (in other words, Xcode has detected the dependency).
Now, if I modify the text of the message in the library source file, then click the "build and run" button, Xcode correctly rebuilds the library, but fails to relink the application, so when the application runs, the unmodified message text is displayed.
I am running Xcode 4.5.1 under Mac OS X 10.8.2.  In the scenario I reported, the application is an iOS single-view application and the static library function being called happens


Hank.” Petty said Carr never tried to profit from the fact that he was driving the country music singer on that last trip.

Carr was a friend of the Williams’ family when the country singer asked Carr to drive him from Montgomery to a show in Charleston, W.Va., on Dec. 31, and a New Year’s Day concert in Canton. They made it to Knoxville and attempted to fly to Charleston, but had to return to Knoxville because of bad weather, according to the Tennessean account. That’s when they set out by car for Canton.

Carr’s father owned a Montgomery cab company at the time.

“My father drove for them from time to time,” Lands Carr said.

A funeral service for Carr will be at 3 p.m. Saturday at Leak Memory Chapel inQ:

Detecting mime-type of a MySQL BLOB in Java

Yes I know that we shouldn't store images on a database, thanks.
That said, is there a way to detect in java the mime type of a BLOB stored in mysql?
It is only for images (.gif, .png, .jpeg, etc.) I don't need a common purpose tool.
Thanks a lot guys

Bonus points if the proposed
  solution does not involve 3rd party
  libs :)

A:

I imagine that you can take a look at the headers. You need to read the data into a byte array and then examine the bytes to see if they match up to the headers for the different file-types.
For example, for a GIF, the first three bytes are "GIF" (4716 4916 4616) followed by either "87a" (3816 3716 6116) or


"89a" (3816 3916 6116).
So something like this should work (uses a FileInputStream for demonstration purposes, but you can get the binary data from a BLOB by using ResultSet#getBinaryStream(int) or ResultSet#getBinaryStream(String)):
import java.io.FileInputStream;
import java.io.FileOutputStream;
import java.io.IOException;
import java.util.Arrays;

public class IdentifyImage {
    public static void main(String[] args) throws IOException {
        FileInputStream in = null;

        try {
            in = new FileInputStream("sample.gif");

            //The following are in base 10
            byte[] gifHeader87a = {71, 73, 70, 56, 55, 97};
        poisoning, bottles and prescriptions of paracetamol should have less than a total dose of 4 g. The authors recommend that unwitnessed exploratory ingestions of paracetamol in children require no treatment if the estimated maximum ingested dose is below 140 mg/kg. Above this dose, treatment is based on the result of a plasma paracetamol level drawn four hours after ingestion. Gastrointestinal decontamination should be reserved for the rare occasions of a definite witnessed ingestion of a dose exceeding 140 mg/kg.


Barbara Boxer attacks fellow members for sleeping in their offices

The meme that members of the House of Representatives are somehow receiving illicit benefits for sleeping in their offices has made its way up the food chain – from a left-wing storefront to the media and now finally to the halls of Congress.

On the Senate floor on Thursday, California Democratic Sen. Barbara Boxer took that ball and ran with it. The liberal senator went after her Republican colleagues and proposed legislation that in the event of a government shutdown would prevent members of Congress from being paid. She also went on a long-winded rant about the so-called hypocrisy of her GOP colleagues.

“[S]o I have written this bill with my colleagues to say that in the event of a government      onGridReady={this.onGridReady}
          />

A:

Empty fields don't show tooltip unless you use tooltipValueGetter:
{
  field: 'athlete',
  minWidth: 150,
  tooltipValueGetter: function(params) {
    return { value: params.value };
},


final String DEBUG_OPTION = "/debug/outgoingSocketCommandHandler"; //$NON-NLS-1$

    private static boolean DEBUGGING = RemoteCommandPlugin.getDefault()
            .isDebugging(DEBUG_OPTION);

    private ISocketAddress remoteAddress;

    private SocketPool socketPool = null;

    /**
     *
     */
    public OutgoingSocketCommandHandler(ISocketAddress remoteAddress) {
        Assert.isNotNull(remoteAddress);
        this.remoteAddress = remoteAddress;
        setRemoteLocation(remoteAddress);
    }

    public void setSocketPool(SocketPool socketPool) {
        this.socketPool = socketPool;
    }

    public IStatus handleOutgoingCommand(IProgressMonitor monitor,
      In a world where psychiatrists were primarily concerned to alleviate suffering, ketamine would have been big-BIG news, long since made widely-available - and ketamine treatment would have been seriously tried-out in the several other serious psychiatric and neurological conditions that respond to ECT such as mania, acute schizophrenia, catatonia and Parkinson's disease (especially Parkinson's disease which is common, and for which ketamine has a plausible pharmacological rationale).

But there is neither money nor status in ketamine - because severe depression is very rare (prevalence about one in a thousand); and ketamine is an old and off-patent drug, used for decades in anaesthesia and with a reputation tarnished by 'street use'.

Big Pharma and their lap-dogs in the mental health leadership have sat-on/ squashed any possible enthusiasm for actually using the


With more than 40,000 CNS tumors diagnosed in children and adolescents every year worldwide, CNS tumors are a leading cause of cancer morbidity and mortality in these patients.^[@b1]^ The complexity of elements needed to provide quality care is substantial, with integration of comprehensive multidisciplinary care comprising accurate pathologic and radiologic diagnosis, neurosurgery, radiation therapy, chemotherapy, rehabilitation, and close monitoring for acute complications and long-term effects. Unfortunately, most children with CNS tumors are diagnosed in low- and middle-income countries (LMICs) where health systems are frequently not adequately equipped to manage such complex cases.^[@b2]^ In addition, data on the incidence, survival, and burden of CNS tumors is currently scant at best, even more so than for other childhood cancers.^[@b3]^

Although international collaborations to improve the outcomes of children with cancer throughthe implementation of capacity-building, research, and education is an effective and sustainable strategy, such efforts have historically not prioritized CNS tumors.^[@b4]^ With increased global support, evidenced by the WHO Global Initiative for Childhood Cancer, special attention must now focus on building capacity to care for children with CNS tumors.^[@b5]^

CNS malignancies comprise a widely varied collection of diagnoses with markedly disparate outcomes, from low-grade tumors to incurable neoplasms.^[@b6]^ Furthermore, advances in genomic medicine have redefined their classification and have impacted treatment in ways that one decade ago were not considered possible. Many CNS tumor types, once thought of as single entities, compose multiple subgroups with distinct clinical and molecular characteristics.^[@b7]^ However, despite the growing list of molecular aberrations identified in pediatric CNS tumors, proven efficacious molecular-based treatments are still


a 9-week online course, and the second was a workshop at the St. Jude campus with 20 participants from seven countries. The workshop, held in November 2019, sought to consolidate acquired knowledge and, more importantly, to share experiences and start to generate ideas for impactful interventions and collaboration.

During the course, barriers to quality care were discussed extensively among participants from different specialties, geographic regions, and health care contexts. Importantly, systematic evaluations of treatment barriers for children with CNS tumors in LMICs are limited.^[@b8],[@b9]^ Salient barriers that were discussed included (1) an absence of coordinated multidisciplinary care; (2) an inability to subspecialize or concentrate on neuro-oncologic diseases; (3) limited infrastructure, including neurosurgical, laboratory, radiotherapy, and rehabilitation facilities; (4) delays in referrals between specialties; (5) postsurgical morbidity; (6) insufficient hospital-Q:

how to design secure database for Mobile recharge codes

Suppose I want to keep millions of recharge codes into a separate database(named A) having a table . I want to design another database(named B) which will be used by a web application.
I want to keep my database A separate and as secure as it can be, preferably not exposed to the network. so that nobody could get access/hack to the huge sensitive data.
But I also have to populate one table of database B with the codes from table of Database A as needed or requested from web application.
I am using Mysql DB and Apache Tomcat as web server .
Can you please suggest me any best and secure way of designing the database keeping in mind that..
1) The safety of


You are here

Assignment: China - A Tale of Two Chinas

This segment in the Assignment:China series focuses on China during the 1990s, when the ongoing crackdown in the wake of the Tiananmen Square protests made it difficult for the American press corps to meet people, travel, or get beyond the stifling bureaucratic obstacles. Reporters and their sources faced continuing surveillance and harassment. However, as the economy took off, the climate for journalists began to improve, and by the late 90s, the China beat entered what one American correspondent described as its "golden age."

China in the 1990s was a paradox. In the wake of the 1989 crackdown in Tiananmen Square, political repression intensified. At the same time, however, following Deng Xiaoping's "Southern Tour" in 1992, the country's economy took off,surveillance and harassment. However, as the economy took off, the climate for journalists began to improve, and by the late 90s, the China beat entered what one American correspondent described as its "golden age."

The film features interviews with journalists who covered China during those years, including such well-known correspondents as Nicholas Kristof and Elisabeth Rosenthal of the New York Times, James McGregor, Joseph Kahn, Ian Johnson, Kathy Chen, and Marcus Brauchli of the Wall St. Journal, Lena Sun, John Pomfret, and Keith Richburg of the Washington Post, Jaime FlorCruz of Time, Rebecca MacKinnon of CNN,, Melinda Liu of Newsweek, and many others, It also includes interviews with American diplomats who handled Chinese affairs, and contains fascinating footage of China from that time.

Assignment: China is a signature project of


UV--vis spectrophotometer, Shimadzu Corp., Kyoto, Japan).

Characterization {#sec4.6}
----------------

The cellulose particles were immersed in liquid nitrogen, freeze-dried in a freeze-dryer (FDU-1200, Tokyo Rikakikai Co., Ltd.; Tokyo, Japan), and observed using a scanning electron microscope (JSM-6510, JEOL, Tokyo, Japan) at an accelerating voltage of 20 kV after platinum coating. To analyze their inner morphology, ultrathin (100 nm-thick) cross sections of the particles were prepared using a cryomicrotome (Leica EM UC6 equipped with EM FC7). The sliced samples were then observed using a transmission electron microscope (JEM-1230, JEOL, Tokyo, Japan). The number-average diameter (*D*~n~) and the coefficient of variation (*C*~v~) was estimated from 200 AgNPs on the TEM images using image analysis (WinRoof, Mitani Co., Ltd., Japan). Nitrogen adsorption measurements were performed using a Quantachrome NOVA 3200e instrument (USA). BET specific surfacesaturation was reached.](pone.0210408.g001){#pone.0210408.g001}

Studies included in the qualitative synthesis {#sec015}
---------------------------------------------

A summary of the characteristics of studies included in the qualitative synthesis is presented in [Table 1](#pone.0210408.t001){ref-type="table"}. Of included studies 15 were conducted in South Africa, 9 in Uganda, 8 in Tanzania, 4 in Swaziland, 4 in Zimbabwe, 3 each in Ethiopia, Kenya, Malawi, and Zambia, and 1 each in Cameroon, Lesotho, Mozambique, Nigeria, Rwanda, Kenya, Nigeria, and Tanzania. Studies examined factors influencing linkage to care, adherence to ART or retention in care amongst adults (n = 22), adolescents or children (n = 10), adults, adolescents and children (n = 2), men (n = 4), women (n = 4), pregnant or postpartum women (n = 7), female sex workers (n = 3), people who inject drugs (PWID) (n = 2),


family responsibilities \[[@pone.0210408.ref041], [@pone.0210408.ref094], [@pone.0210408.ref100]\], or the sudden onset of refugee status \[[@pone.0210408.ref075]\] can lead to a reprioritization of immediate needs. Further disruptions such as loss of support systems \[[@pone.0210408.ref075], [@pone.0210408.ref090]\] or unexpected problems with travel in highly mobile populations \[[@pone.0210408.ref057], [@pone.0210408.ref059], [@pone.0210408.ref081], [@pone.0210408.ref094], [@pone.0210408.ref100], [@pone.0210408.ref104]\] create structural obstacles to attending health services and contribute to gaps in ART care.

Theme 2: Social identity and gender norms can have a profound impact on care-seeking behavior ([S2 Evidence Annex](#pone.0210408.s008){ref-type="supplementary-material"})

Social identity influences how HIV-positive people respond to HIV and ART. When individuals do not fulfil their societal defined roles, they may be judged harshly and ostracized. Many HIV-positive people strive to avoid discrimination and maintain their social identity, and this is sometimes at odds with initiating or continuing ART.

Gender roles impactabout the causes and treatment of HIV \[[@pone.0210408.ref038], [@pone.0210408.ref039], [@pone.0210408.ref043], [@pone.0210408.ref067], [@pone.0210408.ref074], [@pone.0210408.ref079], [@pone.0210408.ref080], [@pone.0210408.ref082], [@pone.0210408.ref091], [@pone.0210408.ref104], [@pone.0210408.ref105]\]. People's beliefs may be informed by religious leaders, politicians, traditional healers, mass media, community members, friends and family \[[@pone.0210408.ref039], [@pone.0210408.ref067], [@pone.0210408.ref080], [@pone.0210408.ref082]\]. All of these influences can facilitate or hinder engagement. Religious and spiritual healers can sometimes offer better explanations and treatments, especially if those belief systems are well established and trusted by communities \[[@pone.0210408.ref038], [@pone.0210408.ref067], [@pone.0210408.ref079], [@pone.0210408.ref080], [@pone.0210408.ref091]\]. Ideologies which offer a cure are particularly appealing to HIV-positive people \[[@pone.0210408.ref039], [@pone.0210408.ref067], [@pone.0210408.ref074], [@pone.0210408.ref091], [@pone.0210408.ref104]\].

Side-effects undermine the message of improved health on ART: Drug side-effects and deterioration on treatment creates doubt regarding the health benefits of ART, and those who feel well when they initiate treatment may as a consequence


supporting evidence presented in this paper and supplementary materials. We included primary studies from across the African continent and did not identify any major themes which occurred exclusively in any one setting, making these finding generalizable to HIV-positive people across Africa. Although there were no studies conducted in prisoners and transgender people which contributed to our synthesis, we believe that some of our findings regarding experiences of marginalized groups may translate to some extent to these populations, it is possible however that some of their unique challenges are missing from this review. There were few studies identified which provided the perspectives of health workers suggesting that the experiences of health workers deserve further research.

We believe this analysis can help provide a springboard at a national or local levelgroup are presented in [Table 1](#T1){ref-type="table"}. There were no significant differences in age, height, and weight between the hypertension and normotension groups; however, the hypertension group had significantly higher BMI (*P* \< 0.001), SBP (*P* \< 0.001), and DBP (*P* \< 0.001) than the normotension group.

Energy, selective nutrients, and calcium intakes
------------------------------------------------

Energy and selective nutrient intake of the subjects is shown in [Table 2](#T2){ref-type="table"}. The average daily energy intake was 1,493.7 kcal for the hypertension group and 1,602.0 kcal for the normotension group without showing a significant difference between two groups. The hypertension group consumed 360.5 mg calcium per day, which was lower than that of the normotension group (429.9 mg), but there was no significant difference. The percentage of people who consumed calcium less than EAR for Koreans


[@CR13]\]. The study was approved for a waiver of written consent by the Loma Linda University Institutional Review Board (\#5130197). Participants provided verbal consent, including permission to audio record the interviews and publish excerpts with identifying information removed (Fig. [1](#Fig1){ref-type="fig"}).Fig. 1Methodology flowchart

Participant selection {#Sec4}
---------------------

We used purposive sampling to compile a list of female academic EM department chairs and previous female presidents of the American College of Emergency Medicine. Participants were recruited via email and telephone. We collected limited demographic data to protect anonymity of participants.

Data collection {#Sec5}
---------------

### Semi-structured interview {#Sec6}

An initial set of interview questions was developed using the intelligent career model (ICM) that sets career development in a social context through growth in three domains: knowing why (focus on purpose), how (focus on skill building), and whombe overt, it may not be as wide spread as it was but there is still gender bias. And when we as women assume that there is none we are doing a disservice to other women. I think women need to be aware that there is still a bias out there and take that into account when they make decisions.Women sought out natural mentors and sponsors to facilitate career development. Are mentors necessary?Mentors provide clear visioning about what people want for themselves. And it has to be real. Not what they should do, but what they really want to do. Find mentors for content development and career advancementSomeone pointed out to me that one person cannot be your be all to end all whether it's in marriage or your children


from them.\
Consciously look for leadership talent that you see. And start it early. I think that means starting with medical students. I think that means residency. You look for that early on. Who has that kind of leadership potential and start actually putting the idea in their heads? So, I might meet with one of my senior residents and just say you know I have noticed that you really have a skill set for leading people through. Have you ever thought about becoming a chair some day? Nobody's talked to them about it, they have never thought about it. Put that little bit of seed of interest in their head and see what happens.\
I think we also must allow people to find their own way, and how tohuman-readable explanation for the group.
	Description string
}

// ToConfigUpdateMap will cast an UpdateOpts struct into a JSON map.
func (opts UpdateOpts) ToConfigUpdateMap() (map[string]interface{}, error) {
	config := map[string]interface{}{}

	if opts.Name != "" {
		config["name"] = opts.Name
	}

	if opts.Description != "" {
		config["description"] = opts.Description
	}

	if opts.Datastore != nil {
		ds, err := opts.Datastore.ToMap()
		if err != nil {
			return config, err
		}
		config["datastore"] = ds
	}

	if len(opts.Values) > 0 {
		config["values"] = opts.Values
	}

	return map[string]interface{}{"configuration": config}, nil
}

// Update will modify an existing configuration group by performing a merge
// between new and existing values. If the key already exists, the new value
// will overwrite. All other keys will remain unaffected.
func Update(client *gophercloud.ServiceClient, configID string, opts UpdateOptsBuilder) UpdateResult {
	var res UpdateResult

	reqBody, err := opts.ToConfigUpdateMap()
	if err != nil {
		res.Err = err
		return res
	}

	_, res.Err = client.Request("PATCH", resourceURL(client, configID), gophercloud.RequestOpts{
		OkCodes:  []int{200},
		JSONBody: &reqBody,
	})

	return res
}

// Replace will modify an existing configuration


group by overwriting the
// entire parameter group with the new values provided. Any existing keys not
// included in UpdateOptsBuilder will be deleted.
func Replace(client *gophercloud.ServiceClient, configID string, opts UpdateOptsBuilder) ReplaceResult {
	var res ReplaceResult

	reqBody, err := opts.ToConfigUpdateMap()
	if err != nil {
		res.Err = err
		return res
	}

	_, res.Err = client.Request("PUT", resourceURL(client, configID), gophercloud.RequestOpts{
		OkCodes:  []int{202},
		JSONBody: &reqBody,
	})

	return res
}

// Delete will permanently delete a configuration group. Please note that
// config groups cannot be deleted whilst still attached to running instances -
// you must detach and then delete them.
func Delete(client *gophercloud.ServiceClient, configID string) DeleteResult {
	var res DeleteResult

	_, res.Err = client.Request("DELETE", resourceURL(client, configID), gophercloud.RequestOpts{
		OkCodes: []int{202},
	})

	return res
}

// ListInstances will list all the instances associated with a particular
// configuration group.
func ListInstances(client *gophercloud.ServiceClient, configID string) pagination.Pager {
	pageFn := func(r pagination.PageResult) pagination.Page {
		return instances.InstancePage{pagination.LinkedPageBase{PageResult: r}}
	}
	return pagination.NewPager(client, instancesURL(client, configID), pageFn)
}

// ListDatastoreParams willlist all the available and supported parameters
// that can be used for a particular datastore ID and a particular version.
// For example, if you are wondering how you can configure a MySQL 5.6 instance,
// you can use this operation (you will need to retrieve the MySQL datastore ID
// by using the datastores API).
func ListDatastoreParams(client *gophercloud.ServiceClient, datastoreID, versionID string) pagination.Pager {
	pageFn := func(r pagination.PageResult) pagination.Page {
		return ParamPage{pagination.SinglePageBase(r)}
	}
	return pagination.NewPager(client, listDSParamsURL(client, datastoreID, versionID), pageFn)
}

// GetDatastoreParam will retrieve information about a specific configuration
// parameter. For example, you can use this operation to understand more about
// "innodb_file_per_table" configuration param for MySQL datastores. You will
// need the param's ID first, which can be attained by using the ListDatastoreParams
// operation.
func GetDatastoreParam(client *gophercloud.ServiceClient, datastoreID, versionID, paramID string) ParamResult {
	var res ParamResult

	_, res.Err = client.Request("GET", getDSParamURL(client, datastoreID,


a language whose output was incorrectly produced by the network, or the size of the largest accepted test set, or the accuracy on a fixed test set [@Rodriguez99arecurrent; @boden2000context; @gers2001lstm; @rodriguez2001simple]. These formulations follow narrow and bounded evaluation schemes though: They often define a length threshold in the test set and report the performance of the model on this fixed set.

We acknowledge three unsettling issues with these formulations. First, the sequences in the training set are usually assumed to be uniformly or geometrically distributed, with little regard to the nature and complexity of the language. This assumption may undermine any conclusions drawn from empirical investigations, especially given that natural language is not uniformly distributed, an aspect that is known to affect learning in modern RNN architectures [@liu-levy-schwartz-tan-smith:2018:RepL4NLP]. Second,they trained an LSTM model until its full convergence on the training set and then tested it on a more generalized set. They showed that their LSTM model outperformed the previous approaches in capturing and generalizing the aforementioned formal languages. By analyzing the cell states and the activations of the gates in their LSTM model, they further demonstrated that the network learns how to count up and down at certain places in the sample sequences to encode information about the underlying structure of each of these formal languages.

Following this approach, @boden2002learning and @chalup2003incremental studied the stability of the LSTM networks in learning context-free and context-sensitive languages and examined the processing mechanism developed by the hidden states during the training phase. They observed that the weight initialization of the


since reconsidered the $1,500 limit and continues to find it justified in light of Congressional budget restraints and competing welfare programs.
[5]  SSI regulations currently allow a $4,500 automobile exemption, and allow total exemption regardless of value if the vehicle is necessary for employment, medical treatment or transportation of a handicapped person. 20 C.F.R. § 416.1218 (1992). Furthermore, SSI regulations also exempt from consideration under the general resource limitation the value of a vehicle that "is necessary because of climate, terrain, distance or similar factors to provide necessary transportation to perform essential daily activities." 50 Fed.Reg. 42683, 42687 (1985).
Q:

Yii redirect on a particular validation fail

I have this validation rule in an user table that makes sure user email is unique. Now I don't want to skip this validation, but want to give an option to the user to choose the existing user data and insert relevant data to another relation table. Is there any way to catch if this particular validation rule fails and then redirect to another controller/action, but I don't want to redirect when any other rule fails.
array('email','unique','message'=>'{attribute}:{value} already exists!'),

A:

Yes ...
Oh, are you asking how to do the above? ;-)
In your controller where you save your model, if saving doesn't work, check for errors for that particular attribute:
$this->getError(<attributeName>);

If the message matches your error above, redirect in your controller. Otherwise, handle the errors as you


                    13
conspiracy to commit perjury based on a witness’s allegedly false testimony at

trial, before a grand jury, or at a post-conviction hearing.”); Strength v. Hubert,

854 F.2d 421, 422-24 (11th Cir. 1988) (concluding investigator for state Attorney

General’s office received absolute immunity for false testimony to a grand jury, at

which the defendant investigator was the sole witness);7 Kelly v. Curtis, 21 F.3d

1544, 1553 (11th Cir. 1994) (holding detective immune for grand jury testimony).

      We recognize that Plaintiff Rehberg alleges Defendant Paulk was the sole

“complaining witness” before the grand jury. However, in Jones, “we expressly

reject[ed] carving out an exception to absolute immunity for grand jury testimony,

even if335.13

       In United States v. Lifshitz, 369 F.3d 173, 190 (2d Cir. 2004), the Second

Circuit cited Guest and noted that the defendant, who challenged the

constitutionality of a probation condition allowing monitoring of his computer,

“may not [] enjoy [] an expectation of privacy in transmissions over the Internet or

e-mail that have already arrived at the recipient.” Id. However, the Second Circuit

       13
          Plaintiff Rehberg points to Warshak v. United States, 490 F.3d 455 (6th Cir. 2007),
reh’g en banc granted, opinion vacated (6th Cir. Oct. 9, 2007) (criminal investigation of
plaintiff), in which a Sixth Circuit panel concluded “that individuals maintain a reasonable
expectation of privacy in e-mails that are stored


before the court is deemed abandoned and its
merits will not be addressed.’” (quoting Access Now, Inc. v. Sw. Airlines Co., 385 F.3d 1324,
1330 (11th Cir. 2004)) (brackets omitted)); see also Snow v. DirecTV, Inc., 450 F.3d 1314, 1321
(11th Cir. 2006) (“a valid civil complaint under the SCA must allege a violation of one of its
provisions”).

                                               29
unconstitutional”).15

       No Supreme Court decision and no precedential decision of this Circuit

defines privacy rights in email content voluntarily transmitted over the 31
hospital and were all made without probable cause.18

          We first review Hartman v. Moore, 547 U.S. 250, 126 S. Ct. 1695 (2006),

which addresses retaliatory-prosecution claims.

A.        Hartman v. Moore

          In Hartman, plaintiff Moore brought a Bivens19 action against postal

inspectors and a federal prosecutor for retaliatory prosecution.20 Because of

Moore’s criticism of and lobbying to the U.S. Postal Service, postal inspectors

launched criminal investigations against Moore and pressured the United States

Attorney’s Office to indict him, “[n]otwithstanding very limited evidence.” Id. at

253-54, 126 S. Ct. at 1699-1700. Although they did not testify, the postal

inspectors drafted “witness statements” for other witnesses and provided them to

the prosecutor, who presented


Paulk and Mr. Hodges instituted an investigation . . .”), 124 (“Chilling his

political speech was a substantial or motivating factor in the wrongful conduct of

Mr. Paulk and Mr. Hodges in investigating Mr. Rehberg . . .”), 157-61 (conspiracy

claim).

       Hartman does not help us with this claim because the Supreme Court

pointedly did not decide whether “simply conducting retaliatory investigation with

a view to promote prosecution is a constitutional tort.” Hartman, 547 U.S. at 262

n. 9, 126 S. Ct. at 1705 n. 9 (“Whether the expense or other adverse consequences

of a retaliatory investigation would ever justify recognizing such an investigation

as a distinct constitutional violation is not before us”).23

       As noted above, only qualified immunity, not absolute immunity, applies to

conductprosecuting him if the prosecutor also is immune from liability for

actually prosecuting the defendant. Rowe, 279 F.3d at 1282. And a witness’s

absolute immunity for testifying prevents any use of that testimony as evidence of

                                          46
the witness’s membership in an unconstitutional conspiracy prior to his testimony.

Id.; Mastroianni, 173 F.3d at 1367.

       Rehberg’s conspiracy allegations do not enlarge what he alleged previously

in his complaint. This opinion has already explained why Hodges, Burke, and

Paulk receive absolute or qualified immunity for all of the conduct


Alberta Premier Rachel Notley

EDMONTON – Alberta Premier Rachel Notley says there will be consequences for British Columbia over the province’s latest attempt to hinder expansion of the Kinder Morgan Trans Mountain oil pipeline.

Notley held an emergency cabinet meeting Wednesday to discuss what legal and economic levers Alberta can pull in its spat with its neighbour to the west.

“The government of Alberta will not — we cannot — let this unconstitutional attack on jobs and working people stand,” she said before the closed-door meeting.

“I’ve called you all together today at this emergency meeting to discuss and evaluate the range of economic and legal options that are available to us including, for example, interprovincial trade in electricity.”

B.C.’s Environment Minister George Heyman said Tuesday that the province plans to ban increased          −35.1 ± 11.0                −52.0 ± 16.7                −61.1 ± 25.0                −73.1 ± 22.0

![Organization of the RNA tetramer on the surface of the GYMLGS aggregate. **(A)** RNA forms different h-bonds on the surface (black circles). **(B)** Detail of the packing of U5 (yellow) with Y residues from the peptide assembly.](fmolb-05-00053-g0004){#F4}

The higher affinity displayed by the SNQNNF-spine can be traced to the higher tendency of the positively charged N-terminals of the constitutive peptides to be exposed


enzyme active sites. In this case, the ligand is described as a cloud of possible conformations that bind at different sites along the surface of a repetitive aggregate.

To proceed along these lines, we combined all the structures visited by RNA when in contact with either peptide sequence into a meta-trajectory. We then conducted a clustering analysis on each of the two meta-trajectories and extracted the central structure of the most populated cluster for each case (See Methods for details). The most representative conformations of RNA in complex with either peptide sequences are qualitatively similar, and are shown in Figure [7A](#F7){ref-type="fig"}.

![The main clusters populated by the model RNA stretch in contact with the amyloid surfaces are found in RNA-protein complexes and shape potential pharmacophores. **(A)** Main conformational clusters ofminus 11%, respectively.

The United States has the world’s highest number of confirmed cases of COVID-19, the respiratory illness caused by the coronavirus, and the Fed has pledged a “whatever-it-takes” approach to keep credit flowing to businesses and households.

On Thursday, Fed Chair Jerome Powell said the central bank would continue to use all the tools at its disposal until the U.S. economy begins to fully rebound. Analysts were especially encouraged by news the Fed would support a broad range of junk debt by purchasing shares of exchange-traded funds (ETFs).

“The announcement today gave the credit markets an adrenaline shot. It can’t stop companies from defaulting, but at least this helps high-yield companies manage borrowing costs while they fight to stay in business,” said Matthew Miskin, co-chief investment strategist at John


Hancock Investment Management.

The Fed’s $2.3 trillion package includes a primary market facility that specifies that companies recently downgraded from investment grade to the first tier of junk - so-called fallen angels - will be eligible for the program.

That includes Ford, whose bond prices rallied and stock jumped 11.3%. Macy’s, another recent fallen angel, also saw bond and share prices rally, with the stock up 11.5%.

“The Fed will buy riskier debt and that should keep this V-shaped rebound going a little longer,” wrote Edward Moya, senior market analyst and forex trader at OANDA. “Solvency pressure on smaller businesses has been somewhat alleviated now that the Fed signaled they will buy some junk-rated corporate debt.”

Analysts at Citi said while it was widely expected the Fed might help fallen angels, “itincluding 72 investment grade-rated names, of which 15 issued corporate bonds shortly thereafter.

“As the world economy enters the deleveraging phase of the recession, credit will emerge as a favored asset class for investors wishing to position for an eventual recovery,” wrote Oxford Economics’ director of macro strategy, Gaurav Saroliya.


think people just mix and match however they want, however they feel,” Redesiuk said. “And even society is more open to different kinds of relationships.”

This is not to say that the player should see this kind of advertising as good. Redesiuk said that it was designed to feel jarring and overly aggressive, like all the other ads in the game, but not because of the femme-presenting trans model.

“Cyberpunk 2077 is a dystopian future where megacorporations dictate everything,” Redesiuk said. “They try to, and successfully, influence people’s lives. They shove products down their throats. They create those very aggressive advertisements that use, and abuse, a lot of people’s needs and instincts. So, hypersexualization is apparent everywhere, and in our ads there are many examples of hypersexualized women, hypersexualized men,Advance Publications. Read more.

VENTURE CAPITAL DEALS

• Tanium, a San Francisco-based systems and security management company, has raised $52 million in new VC funding from Andreessen Horowitz. This follows up a $90 million investment in the company from Andreessen Horowitz last summer – the company’s first round of VC funding since being launched in 2007 – at a reported valuation of $900 million. Read more.

• Sprinklr, a New York-based marketing startup, has raised $46 million in Series E funding from existing investors Intel Capital, Battery Ventures and Iconiq Capital. The round, which brings Sprinklr’s total funding to $123.5 million, values the 700-person company at $1.17 billion. Read more.

•Augure, a French provider of influence engagement software, has raised $16 million in new funding. Seventure Partners and Bpifrance were joined by


return backers Serena Capital, Ventech,OTC Agregator, and Amundi. www.augure.com

• GlassesUSA, an online retailer specializing in prescription eyewear, has raised $12.5 million in new funding led by Viola Private Equity. www.glassesusa.com

• Advanced Practice Strategies Inc., a Boston-based e-learning and talent management platform for clinicians, has raised $12 million in Series C funding. River Cities Capital Funds led the round, and was joined by return backer Ascension Ventures. www.aps-web.com

• SmartNews, a Japanese social news aggregation app, has raised $10 million in new VC funding at a $330 million post-money valuation. GREE led the round, and was joined by return backer Atomico, Globis Capital Partners, Mixi and Social Venture Partners. Read more.

• DroneDeploy, a San Francisco-based provider of cloud software for commercial drone operations, has raised $9 million in Series Afunding. Emergence Capital led the round, and was joined by return backers SoftTech, DataCollective and Angelpad. www.dronedeploy.com

• ProsperWorks, a San Francisco-based provider of CRM solutions that are built in or around Google Apps, has raised $7.5 million in Series A funding. True Ventures led the round, and was joined by return backers like Bloomberg Beta and Crunchfund. www.prosperworks.com

• Ready Pulse, a San Carlos, Calif.-based provider of social marketing software, has raised $5 million in Series A funding from Walden Venture Capital and Rally Ventures. www.readypulse.com

• GoFormz, a San Diego-based mobile-first productivity solution, has raised $3 million in Series A funding from Cloud Apps Capital Partners and Floodgate. www.goformz.com

• SenionLab AB, a Swedish provider of indoor positioning systems, has raised $1.8 million in new VC funding from SEB Venture


bit opaque.

~~~
cangencer
As someone who had to teach myself kdb/Q recently, I can recommend the Q for
Mortals book:
[http://code.kx.com/wiki/JB:QforMortals2/contents](http://code.kx.com/wiki/JB:QforMortals2/contents)

~~~
jd-uk
This is a bit of a _plug_ but anyone interested in learning about kdb/Q can
take a look here: [http://www.timestored.com](http://www.timestored.com)

They have some interactive, online kdb/Q tutorials with programming questions
and answers to try out the language and get a feel for it.

There is also an IDE for day-to-day users of kdb/Q with lots of convenient
features

------
mercurial
A "data language", in this context, is a language for representing and
validating data. I'm not clear on why it's called "Q", or why it calls
marshalling/unmarshalling undressing/dressing. The language itself looks
alright, it's dependently typed. It doesn't say anything about the speed of
the existing JS/Ruby implementations.

~~~
hgh
Perhaps the name is based off the R language (which came from S), a major
data/stats language. Databecause you can practically use this to define a grammar for parsing
a programming language, because:

1\. Each data type can inline express its own value constraints (not just type
constraints, but rather value constraints) which is key to source code parsing

2\. With subclasssing you can combine data types into higher level objects
that inherit all of the lower level value constraints. This is similar to how
a recursive lexer drills down from a high level statement into the different
parts of each statement.

3\. The data type value constraints support sequences, alternatives, and
unions, most of what a lexer needs to parse a language based on a grammar spec

With these ingredients you can actually parse code, and thereby write a code
interpreter (or parser at least). You begin with a grammar rule (a high level
data type)


no wait... Or _Grammeme_ , the well-known
combination of grammar and meme
([https://en.wikipedia.org/wiki/Grammeme](https://en.wikipedia.org/wiki/Grammeme))?

------
bane
Oh dear, this might conflict with a SQL variant we cooked up at my old company
called Q-Lang. Where you could write a SQL statement, leave bits of the WHERE
clause "blank" and it would generate a GUI interface with drop downs and
calendars and everything to let people fill in those bits without too much
effort. Nothing terribly fancy, but it let you go from a working example SQL
statement to an integrated query interface in the app in about 10 minutes.

It had lots of limitations, but most of the time it absolutely annihilated
some of our competition's multi-month integration engagements.

------
dj-wonk
Q is trying to do both data and validation, which are very different problem
spaces. I think designing for both involves serious tradeoffs formay occur. Finally, the last column presents example scenarios for that kind of anomaly that are investigated in this study. Note that, as seen from the table, each anomaly type may occur in any of the given example scenarios. For example, while constructing a tower, an object in the environment may disappear, its location may be changed or the tower may collapse.

Anomaly Identification
======================

In this section, we first explain the underlying hardware and software structure for detecting anomalies which directly contributes to the anomaly identification problem. It is important to present the low-level procedures and our hardware setup to clarify the anomaly identification procedure on top of them. We then present our Long-Short Term Memories (LSTM) based anomaly identification procedure. Furthermore, the implementation of Hidden Markov Models (HMM) and


is not over and an anomaly is not detected, the observations are gathered through the sensors and stacked to the history. In case of an anomaly, likelihoods are calculated to reveal the model that fits most to the observation sequence (in other words, the model that is more likely to generate the observation sequence), and the model with the highest likelihood is selected. This is followed by executing the Viterbi algorithm with the selected model on the sequence. Note that since the scope of the manuscript is anomaly identification, the labels are only assigned in case of an anomaly. Therefore, if an anomaly does not occur, the algorithm labels all the sequence with *safe* label. The procedure terminates with returning the labelled sequence.

CRFs for Anomaly Identification
-------------------------------

Conditional Random Fieldsshows the interpretation of the sensor values gathered by the robot during such an anomaly case (Figure \[external\]). The figure includes six plots, and each of them illustrates a different sensor data or interpretation. x axes of all graphs indicate the time in seconds where y axes denote the corresponding value for that feature. The first graph indicates the force in the gripper of the robot. Whenever the gripper is empty (an object is not being hold), it is zero. Otherwise, it produces a value other than zero indicating that there is an object in the gripper. The second graph illustrates the position of the gripper pedals. Whenever they are closed, it is almost zero. Otherwise, depending on the object’s size at hand, it has a value other


function during a training phase for the LSTM model. As can be seen from the plot, the loss decreases and converges as number of epochs increase. The f-score values for the related models at corresponding epochs are also shown in the plot. It can be seen that after epoch 300, the f-score does not change, and it can be inferred that the trained model converges.

During the experiments, the following aspects are investigated. First, the performance analysis of the methods is presented in terms of the classification rate of the states, and also confusion matrices are presented. Second, the general classification accuracies of the methods in terms of the overall anomaly identification decision for the scenarios are presented as confusion matrices.

### State Classification Accuracy on the Observation Sequence

The methodsexamples where resistance can ultimately translate into victory. If your goal is not to win but rather to simply wear your enemy down, then it is often possible for the “weaker” party to prevail. For examples of that look no further than our own American Revolution. An army of farmers armed with muskets defeated the mightiest military on the face of the earth. Likewise the tables were turned in Vietnam when we, with the mightiest military on the face of the earth, were defeated by a grass roots militia. Some might quibble over the details of these examples, but there are plenty of others and it does not detract from the underlying point, which is that a weaker party can overcome a stronger party even when they may


should always be mindful that we do not live in a vacuum and that our actions may have far reaching consequences for others. The “Golden Rule” may not solve the problem, but I’m quite certain it can’t possibly make it worse.

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Consent…

All human interactions should be voluntary. Action upon another without consent (i.e. aggression) is the embodiment of evil. Virtue transforms to vice where consent is absent: love becomes rape, generosity theft, and labor slavery. Where consent exists there is liberty, but where it is absent, only captivity. The pursuit of laudable ends does not exonerate the evils of aggression. While the state purports to own us, we can never be free.

Tom Woods’ Liberty Classroom

If this site has sparked an interest in not-officially-approved-opinion and youNUCLEAR TESTS

asked the Prime Minister what information he has received from the United States Administration on the recent leakage of radiation in Nevada after underground nuclear tests; if he will request the United States Administration, in the interests of the health of the peoples of the world, to refrain from conducting further underground tests until it is certain that there can be no further leakages; and if he will intensify his efforts to secure a complete ban on all such tests.

Can my right hon. Friend say whether his circulated Answer contains any reference to the previous radiation leak a few years ago, after tests for which the then British Government were partly responsible? Does he recall that we were then given assurances that it was unbelievable that there


right about this. The test carried out a few days ago—which, I gather, was about 130 kilotons—has undoubtedly involved a considerable amount of fall-out, although it may take a few days—perhaps up to a month—before it is possible to calculate exactly how much fall-out has occurred from this test, which is not a breach of the test ban agreement because China is not a member, but which is completely opposed to what the whole of mankind wants to see.

While we will continue to urge the Prime Minister to attempt to secure an overall ban on tests, can he confirm that there was no leakage from the last British underground test, and that he will therefore continue with such tests as necessary?

That seems to be rather a different question.molecular patterns.](fimmu-08-01863-g001){#F1}

Pathogen-Triggered Cell Death {#S2}
=============================

Apoptosis is a caspase-dependent programmed form of regulated cell death resulting in a series of well-characterized morphologic and molecular changes culminating in membrane blebbing, DNA fragmentation and expression of signals designed to attract phagocytes and trigger engulfment and disposal of the apoptotic cargo ([@B17]). Apoptotic cells that are not rapidly efferocytosed become late apoptotic cells with a phenotype related to that of necrosis and are pro-inflammatory ([@B21], [@B22]). Apoptosis may be triggered in various cell types by a variety of pathogens, including intracellular bacteria ([@B23]), parasites ([@B24]), and viruses ([@B25]). Despite having evolved in part as a mechanism to limit pathogen replication and spread, apoptosis may have been subverted to contribute to pathogen survival and disease pathogenesis as discussed below. Pyroptosis is a regulated


only does efferocytosis reduce mycobacterial viability in human cells but also allows cross-presentation by DC of mycobacterial antigens for MHC class-I and CD1 presentation to CD8^+^ T cells in mice, reinforcing adaptive anti-bacterial immunity ([@B85]). The importance of macrophage apoptosis as an anti-mycobacterial mechanism contrasts with the finding that some virulent forms of *M. tuberculosis* have evolved to divert apoptotic cell death toward a programmed necrotic pathway, which fails to inhibit bacterial growth and allows bacterial release from the disrupted cell, promoting pathogen dissemination ([@B79], [@B81], [@B86], [@B87]). Thus, the type of cell death induced directly influences the outcome for the pathogen.

Bacteria may use efferocytic pathways to escape from elimination or to assist their dissemination using Trojan-horse-type mechanisms in which dying cells carrying viable bacteria are engulfed leadinglymphocytes results in the establishment of an anti-inflammatory response dictated by TGF-β and prostaglandin PGE2 that fuels parasite persistence and disease ([@B126]). Treatment of *T. cruzi* infected mice with inhibitors of apoptosis reversed the anti-inflammatory phenotype and reduced *ex vivo* parasite replication ([@B123], [@B127]), consistent with efferocytosis of apoptotic cells reducing macrophage anti-parasite activity and enhancing parasite persistence and disease.

Immune Consequences of Infected Cell Efferocytosis {#S6}
==================================================

The outcome for the phagocyte of engulfment of an infected dying cell is influenced both by the infecting pathogen and by the mode of death elicited in the target cell. PS exposed on apoptotic cells delivers an anti-inflammatory signal that is associated with defined receptor and signaling pathways and the production of regulatory cytokines such as TGF-β and IL-10 ([@B11], [@B66]) and is


Dunn School of Pathology.

[^1]: Edited by: Christel Vérollet, UMR5089 Institut de Pharmacologie et de Biologie Structurale (IPBS), France

[^2]: Reviewed by: Mark Marsh, University College London, United Kingdom; Philippe Benaroch, Centre national de la recherche scientifique (CNRS), France; Serge Benichou, Centre national de la recherche scientifique (CNRS), France

[^3]: Specialty section: This article was submitted to Microbial Immunology, a section of the journal Frontiers in Immunology
the pot he had in his possession -- three-and-a-half ounces worth -- was confiscated. He's now been charged with unlawful distribution of marijuana of less than five pounds with a prior conviction.

Walton subsequently posted a $1,500 bond and was released. Meanwhile, the DCSO offers this message:

Note: Amendment 64 authorizes possession of marijuana. However, there is no law authorizing the distribution or sale of marijuana (except medical marijuana).


before you can post or view full size images in the forums.

Help with stairs and multi-level maps using CC3

I've been DMing some online DnD games and recently got fed up with simple drawing tools and pregened maps, so I decided to take the plunge and start doing my own cartography. I've been reading these forums quite a bit and have found it extremely helpful in hitting the ground running with the software I use (CC3). Anyways, I've created and played a few maps so far and I'm having a blast - great maps add an extra level of immersion, my players love them, and it feels good to use something that you created yourself.
One concept I'm having a hard time portraying though, is showing multiple elevation levels, andlightest on the 2nd floor and darkest at the foot of the stairs.

If you wanna get into more detail - those stair symbols you have already have a shadow created for them. So putting one next to the other may look a little odd. To get around that, you could individually draw each step and put it on its own sheet and add a drop shadow effect to the sheet (messing with the sun direction to make sure the shadow faces the stair below it). I've done this for maps that have a few steps - never as many as you have here.

Alternatively, you create a new symbol in photoshop and drop it in. I'm unfortunately not very good at that...

Well, I am completely new to CC3 (picked


the value 1, or would it see the value 303?
On the other hand, if we have
void myFunction() {
    int x;
    x = 303;
    printf("%d\n", x);
}

It is a bit more clear that we are supposed to execute these statements in order, so 303 would be printed.
Hope this helps!

to present some other
allegations.  You will find out some of those are every bit as bizarre as this.  You will
find out that none of those have been formalized into a criminal accusation of any
kind.
* * *
	And following the law the Judge tells you, you can hear any type of other matters, but
you're required to keep focused on the [complainant's] accusation.  You have to
believe other matter, first off, beyond a reasonable doubt and for a narrow purpose.

 	The complainant (S.D.) testified at appellant's July 2005 trial that appellant molested her in
his church office in February 1994 and in the church parking lot in June 1994 when the complainant
was 16 years old.  The complainant testified that she decided to make a police report in August 2004,
after


The ANC, the majority party in parliament, on Wednesday voted to grant former president Jacob Zuma generous pension benefits as well as agreeing to continue to pay his medical aid costs.

The Independent Commission for the Remuneration of Public Office Bearers had recommended last month that the pension and medical aid benefits Zuma should get should be equal to 100% of his salary upon retirement, that his estate should apparently continue to benefit from it even after he dies and that he should continue to get increases to ensure his salary remains in line with that given to the sitting president, in this case President Cyril Ramaphosa.

It was reported earlier this year that Ramaphosa currently earns about R3.6 million a year. He pledged half of that to a charitablecounter that sits in the middle of the dial

The classy rear spoiler keeps the 200mph-plus supercar on the road while it is driving

The auctioneer's car specialist added that the McLaren supercar has long been regarded as the benchmark by which all others are compared

Out of the top ten most expensive cars ever sold at auction the McLaren will be the only one built later than 1967

'No other car stirs more emotions and evokes more excitement.

'The level of ownership exclusivity and 'holy grail' admiration associated with the F1 is second only to the Ferrari 250 GTO, making this an excellent follow up to our 2018 sale.

'It truly is an opportunity not to be missed.'

Of the top ten most expensive cars ever sold at auction the McLaren will be the


different physical hosts & see if it goes away.    (There is a rare chance your code is very very bad and you are saturating the network between the CF box and the MySQL box, but I'm not sure it's possible to write code that bad)

Expression and diagnostic evaluation of the human tumor-associated antigen RCAS1 in pancreatic cancer.
Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is one of the membrane molecules expressed on human cancer cells and is presumed to play a protective role for tumor cells against immune surveillance by inhibition of clonal expansion and induction of cell death in immunocytes. To address whether RCAS1 is expressed in pancreatic cancer and whether serologic diagnostic evaluation is useful compared with that of carbohydrate antigen 19-9 (CA19-9) and soluble Fas ligand. Immunohistochemical expression of RCAS1 was examined by staining with a 22-1-1 monoclonal antibody, and serum RCAS1 concentrations were determined by an enzyme-linked immunosorbent assay in 20 cases of ductal adenocarcinoma of the pancreas and other pancreatic diseases. Immunohistochemically, RCAS1 detection occurred in 100%


wild relatives. Tomatoes originated in Peru, Chile, Ecuador, and Mexico, and they were brought to colonial America through Europe. During the early 20th century, they were crossed with wild species to make the tomatoes we have today.

The researchers were able to identify latent genes that migrated into breeding lines along with genes deliberately introduced to confer desirable traits. The results, published in BMC Plant Biology (2012), showed, for instance, how a gene introduced for disease resistance carried with it a gene that influenced fruit ripening. The work sets the stage for more detailed studies on the effects of linkage drag on tomato breeding efforts, elimination of undesirable genes from breeding stocks, and identification of more desirable sets of genes for tomato breeders.

The researchers are optimistic that both studiesCosting essential services package provided by a non-governmental organization network in Bangladesh.
The health profile of Bangladesh has improved remarkably, yet gaps in delivering quality health care remain. In response to the need for evidence to quantify resources for providing health services in Bangladesh, this study estimates unit costs of providing the essential services package (ESP) in the not-for-profit sector. This study used a stratified sampling approach to select 18 static clinics, which had fixed facilities, from 330 non-profit clinics under Smiling Sun network in Bangladesh. Costs were estimated from the providers' perspective, using both top-down and bottom-up methods, from July 2014 to June 2015. In total, there were 1115 observations (clients) for the 13 primary care services analysed. The estimated 2015 average costs per visit were: antenatal care


# Licensed to the Apache Software Foundation (ASF) under one or more
# contributor license agreements.  See the NOTICE file distributed with
# this work for additional information regarding copyright ownership.
# The ASF licenses this file to You under the Apache License, Version 2.0
# (the "License"); you may not use this file except in compliance with
# the License.  You may obtain a copy of the License at
#
#    http://www.apache.org/licenses/LICENSE-2.0
#
# Unless required by applicable law or agreed to in writing, software
# distributed under the License is distributed on an "AS IS" BASIS,
# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
# See the License for the specific language governing permissions and
# limitations under the License.

# Name configure audit appender through "hdfs.audit.logger"
#hdfs.audit.logger=INFO,console, KAFKA_HDFS_AUDIT,DRFAAUDIT
#log4j.logger.org.apache.hadoop.hdfs.server.namenode.FSNamesystem.audit=${hdfs.audit.logger}
#log4j.additivity.org.apache.hadoop.hdfs.server.namenode.FSNamesystem.audit=false
#

log4j.appender.KAFKA_HDFS_AUDIT=org.apache.eagle.log4j.kafka.KafkaLog4jAppender
log4j.appender.KAFKA_HDFS_AUDIT.Topic=sandbox_hdfs_audit_log
log4j.appender.KAFKA_HDFS_AUDIT.BrokerList=sandbox.hortonworks.com:6667
log4j.appender.KAFKA_HDFS_AUDIT.KeyClass=org.apache.eagle.log4j.kafka.hadoop.AuditLogKeyer
log4j.appender.KAFKA_HDFS_AUDIT.Layout=org.apache.log4j.PatternLayout
log4j.appender.KAFKA_HDFS_AUDIT.Layout.ConversionPattern=%d{ISO8601} %p %c{2}: %m%n
log4j.appender.KAFKA_HDFS_AUDIT.ProducerType=async
log4j.appender.KAFKA_HDFS_AUDIT.BatchSize=1
log4j.appender.KAFKA_HDFS_AUDIT.QueueSize=1which can be overridden:
override def exceptionHandler = {
   case e: Exception =>
      println(e.getMessage())
}

Whenever a exception is raised in the actor that would normally cause it to terminate - the exceptionHandler partial function is applied to the exception.

Edit
With Exception filter:
  class ExceptionalActor extends Actor{

    def act() {
      loop {
        react {
          case "bad" => throw new NoSuchFieldException("Bad Message")
          case "impossible" => throw new Exception("Impossible Exception")
          case m => println("non-bad message " + m )


537 F.Supp. 1024 (1982)
STERLING RECREATION ORGANIZATION CO., Plaintiff,
v.
David M. SEGAL and Bruce B. Paul, Defendants.
Civ. A. No. 81-K-2013.
United States District Court, D. Colorado.
April 27, 1982.
*1025 John D. Phillips, Jr., Daniel R. Satriana, Jr., Hall & Evans, Denver, Colo., for plaintiff.
Donald Bain, Edmond F. Noel, Jr., Holme, Roberts & Owen, Denver, Colo., for defendants.
KANE, District Judge.
This case involves the sale of a Colorado radio station from the defendants to the plaintiff. The sale was effected by an agreement that transferred all of the station's outstanding capital stock from the defendants to the plaintiff. The plaintiff alleges that the defendants made various negligent and intentional misrepresentations regarding the station in the agreement. Its first claim for relief, securities fraud, is brought under the Securities Act of 1933, 15 U.S.C. §§// Aseprite Base Library
// Copyright (c) 2001-2013, 2015 David Capello
//
// This file is released under the terms of the MIT license.
// Read LICENSE.txt for more information.

#include <ctime>
#include <sys/time.h>

class base::Chrono::ChronoImpl {
public:
  ChronoImpl() {
    reset();
  }

  void reset() {
    gettimeofday(&m_point, NULL);
  }

  double elapsed() const {
    struct timeval now;
    gettimeofday(&now, NULL);
    return (double)(now.tv_sec + (double)now.tv_usec/1000000) -
           (double)(m_point.tv_sec + (double)m_point.tv_usec/1000000);
  }

private:
  struct timeval m_point;
};


express element of mens rea, implies that the other

definition has no element of mens rea. See Fedorenko v. United States, 449 U.S.

490, 512–13, 101 S. Ct. 737, 750 (1981) (explaining that the “deliberate omission

of [a] word” that appears in an adjacent textual provision “compels the conclusion”

that the omitted word should not be “impl[ied]”). Although we have stated in dicta

that distribution occurs “[w]hen the user [of a file sharing program] knowingly

makes the files [on his computer] accessible to others,” Spriggs, 666 F.3d at 1287,

our dicta cannot be squared with the plain language of the commentary.

                                  Gay guys online dating | SINTUNADO DATING

Digital dating is a lot like driving a car. Or so says Joanna Coles, the Chief Content Officer of Hearst Magazines and author of the new book "Love Rules: How to Find a Real Relationship in the ... Sussex County Clerk County Records Gis Maps, Land Records Search Sussex County Clerk public records database by instrument number, date range, name, document type, book/map and page/map. G) smartorder: this is a tool which is used to increase trading speed and improve the process of managing positions. education and demo accounts educational materials on activtrades abound for the benefit of educating the new trader. De multe ori, cand mergi in magazinele de specialitate pentru a-ti cumpara condimente specifice bucatariilor internationale, tot ceea ce vezi


including images, documents, audio files and PDF, the presentation covers topics such as convoys, Anglo-American cooperation, special intelligence, the Enigma code, and the Drumbeat crisis. There are a couple of interactive resources, including a virtual Enigma feature.

He then formally declared war against Pedro Lopez, the leader of the slave-drivers, enrolled a band of runaway slaves in his service, armed them, and conducted a campaign, which ended by his killing with his own hands the notorious half-breed and breaking down the system which he represented. This dating websites before you free to one destination for an anonymous online dating life with too good match we have listed to ensure you. Many profiles, your credentials in rooftop and men out-number the date quickly. What Does Xoxo Mean In Texting .        : TestApplicative<S, laws>{applicatives}
        {
            _injection<0> f{};
            _injection<1> g{};
            using test::ct_eq;
            constexpr auto list = make<S>;

            //////////////////////////////////////////////////////////////////
            // ap
            //////////////////////////////////////////////////////////////////
            BOOST_HANA_CONSTANT_CHECK(hana::equal(


     BOOST_HANA_CONSTANT_CHECK(hana::equal(
                hana::ap(list(f, g), list(ct_eq<0>{})),
                list(f(ct_eq<0>{}), g(ct_eq<0>{}))
            ));
            BOOST_HANA_CONSTANT_CHECK(hana::equal(
                hana::ap(list(f, g), list(ct_eq<0>{}, ct_eq<1>{})),
                list(f(ct_eq<0>{}), f(ct_eq<1>{}), g(ct_eq<0>{}), g(ct_eq<1>{}))
            ));
            BOOST_HANA_CONSTANT_CHECK(hana::equal(
               hana::ap(list(f, g), list(ct_eq<0>{}, ct_eq<1>{}, ct_eq<2>{})),
                list(f(ct_eq<0>{}), f(ct_eq<1>{}), f(ct_eq<2>{}),
                     g(ct_eq<0>{}), g(ct_eq<1>{}), g(ct_eq<2>{}))
            ));

            //////////////////////////////////////////////////////////////////
            // lift
            //////////////////////////////////////////////////////////////////
            BOOST_HANA_CONSTANT_CHECK(hana::equal(


Nicholas will serve in a strategic advisory role within the new company. Please register, and get one.

Download BCM 10/ Ethernet Network Adapter

BRCM and now employs approximately 11, people worldwide in more than 15 countries. Please bcn us maintain a helpfull driver collection. Other drivers most commonly associated with Bcm 10 Ethernet Network Adapter problems: Broadcom is among Gartner’s Top 10 Semiconductor Vendors by revenue.

I wil keep coming back for sure. Bcm 10 Ethernet Network Adapter It was acquired by Avago Technologies in and currently operates as a wholly owned subsidiary of the merged entity called Broadcom Limited. Bcm 10 Ethernet Network Adapter V Would you use this site again?: PC Pitstop will NOT share or sell your email address and we have the appropriate procedures to safeguard againstof a direct order to be present at a certain time.
After reviewing the record in the case at bar and the authorities noted, we hold that, as a matter of law, claimant's conduct here did not constitute misconduct within the meaning of ORS 657.176(2)(a). Perhaps claimant overreacted to the frantic telephone call from her daughter. We need not pass judgment on that question because claimant's conduct did not constitute "an act of wanton or wilful disregard of the employer's interest" or "negligence in such degree or recurrence as to manifest culpability, wrongful intent, or evil design, or show an intentional and substantial disregard of the employer's interest * * *." At most, her conduct was an isolated instance of poor judgment. We do not believe that claimant should


coordinated Mg^2+^ ions (cyan).(E) Liquorice-surface representation of *h*ARH1 and *Lch*ARH3 (brown) in complex with ADPr (black). Residues important for the interaction are highlighted (see [Figures S1--S3](#mmc1){ref-type="supplementary-material"} for further details).See also [Figures S1--S3](#mmc1){ref-type="supplementary-material"}.

Macrodomains are structurally well characterized and several structures are available of their apo- and ligand-bound forms, including at least one representative of each macrodomain class found in humans (MacroH2A-like, MacroD-type, ALC-like and PARG-like) (reviewed in [@bib3], [@bib56]). In contrast, eukaryotic ARH family members are poorly understood and thus far only apo structures for ARH3 are available in the literature ([@bib42], [@bib43]), and one unpublished ADP-bound structure of ARH1 is deposited in the Protein Databank (PDB: [3HFW](pdb:3HFW){#intref0010}).

Although ARHs catalyze reactions that appear to be unique in higher organisms, very little is known about their physiological function. So far weReaction mixture was stirred at RT for 1 h, then cooled to 0°C and t-BuOOH was added as a 5.5 M solution in decane (0.13 mL, 0.72 mmol, 2.0 eq). Reaction was stirred at 0°C for 1 h. Solvent was removed by rotary evaporation (60°C bath temp.). Residue was redissolved in CH~3~CN (5 mL) and H~2~O (5 mL). Triethylamine (3 mL) was added and mixture was stirred overnight at RT. Solvent was removed by rotary evaporation. Tetrabutylammonium cation was exchanged by elution through Dowex 50Wx2 resin (Et~3~N-form). Purification via C18 chromatography was performed, product eluting with ∼30% CH~3~CN/H~2~O (160.2 mg, 52%).

^**1**^**H NMR** (500 MHz, CD~3~OD) δ 8.55 (s, 1H), 8.20 (s, 1H), 6.09 (d, *J* = 5.4 Hz, 1H), 4.64 (t, *J* = 5.3 Hz, 1H), 4.45 (dd, *J* = 5.1, 3.5 Hz, 1H), 4.39 -- 4.32 (m, 3H), 4.29 --


Data Bank ([www.rcsb.org](http://www.rcsb.org){#intref0215}) under accession codes [6G28](pdb:6G28){#intref0220}, [6G2A](pdb:6G2A){#intref0225}, [6G1P](pdb:6G1P){#intref0230}, [6G1Q](pdb:6G1Q){#intref0235}, [6HGZ](pdb:6HGZ){#intref0240}, [6HH3](pdb:6HH3){#intref0245}, [6HH5](pdb:6HH5){#intref0250}, [6HOZ](pdb:6HOZ){#intref0255}, [6HH4](pdb:6HH4){#intref0260}, [6HH6](pdb:6HH6){#intref0265}, respectively.

Supplemental Information {#appsec2}
========================

Document S1. Figures S1--S7 and Tables S1--S3Data S1. NMR Spectra Concerning the Synthesis of ADP-HPM, Related to STAR MethodsDocument S2. Article plus Supplemental Information

We thank Friedrich Koch-Nolte (Universitätsklinikum Hamburg-Eppendorf) for providing us with the *m*ARTC2.2 expression construct, Helena Choltus (Université Blaise-Pascal) for assistance with plasmid preparation and initial expression trails, Ian Gibbs-Seymour (Sir William Dunn School of Pathology) for critical reading of the manuscript, and Diamond Light Source for access to beamlines I03, I04, I04-1, and I24 (proposal numbers mx12346 and mx18069), which contributed to the results presented here. Some NMR data were collected in the Institute for Genomic Biology Core on a 600-MHz NMR funded by NIH grant numberby Sen. Tom Coburn (R., Okla.) details widespread cybersecurity breaches in the federal government, despite billions in spending to secure the nation’s most sensitive information. The report, released on Tuesday, found that approximately 40 percent of breaches go undetected, and highlighted “serious vulnerabilities in the government’s efforts to protect its own civilian computers and networks.” “In the past few years, we have seen significant breaches in cybersecurity which could affect critical U.S. infrastructure,” the report said. “Data on the nation’s weakest dams, including those which could kill Americans if they failed, were stolen by a malicious intruder. Nuclear plants’ confidential cybersecurity plans have been left unprotected. Blueprints for the technology undergirding the New York Stock Exchange were exposed to hackers.”

Yikes.

And things are not much better when it comes


for dismissal.

Background

     On March 3, 1993, respondent mailed a notice to petitioner

proposing adjustments to his Federal income tax for 1990.    The

notice was mailed to petitioner at 4948 Crystal Drive, San Diego,

CA 92109-2062 (the Crystal Drive address).    The Crystal Drive

address is the address listed on petitioner's 1990 tax return,

which petitioner filed with respondent on April 15, 1991.    On or

about March 10, 1993, the envelope bearing the notice was

returned to respondent marked "RETURN TO SENDER UNABLE TO

FORWARD".

     On August 18, 1993, respondent mailed a notice of deficiency

to petitioner determining a deficiency of $3,101 in his Federal
                              - 3 -

income tax for 1990.   The notice of deficiency was mailed to

petitioner at the Crystal Drive address.    The envelope bearing

the notice of deficiency was returned to respondent marked

"UNABLE TO FORWARD".

     According to petitioner, he moved from the Crystal Drive

address on approximately September 1, 1991.    Petitioner further

asserts that he resided at 4875 Santa Cruz Avenue, San Diego, CA

92107 between that date until his move to 4776 Bayard Street, San

Diego, CA 92109 (the Bayard Street address) on February 1, 1992.

Petitioner notified respondent of his change of address to the

Bayard Street address sometime in March 1995.    Petitioner filed

his tax returns for 1991


Resources

The Budget for 2017/2018 has not had a large impact on SMSFs compared to the previous year.

The following guide designed to provide you with a summary of the measures affecting SMSFs and what it means for SF360. The full impact of these will now be known until the draft legislation is released.

Housing Affordability - Downsizing exemption to superannuation caps

Start Date

1 July 2018

Intent

This measure is designed to encourage some people to downsize into housing that is more suitable to their needs, freeing up larger family homes.

It will assist people aged 65 and over who are currently unable to contribute all or any proceeds of the sale of their home into superannuation because of the existing restrictions and caps.

Summary

Individuals aged 65 and over will be able to downsize their familylimit which is currently $100,000.

Any change in the person's superannuation balance as a result of this measure will count towards the Age Pension assets test.

Example 1

George and Jane, both retired and aged 76 and 69, sell their home to move into more appropriate accommodation. The sale proceeds are $1.2 million. They can both make a non-concessional contribution into superannuation of $300,000 ($600,000 in total), even though Jane no longer satisfies the standard contribution work test and George is over 75. They can make these special contributions regardless of how much they already have in their accounts.

Example 2

John and Sarah, who are still working part-time at age 65, decide to sell the large family home after all the children move out. The sale proceeds are $1.4 million. They are


Active treatments have been attempted, and the effectiveness of laser therapy and photodynamic therapy (PDT) have been demonstrated. Ongoing studies of bevacizumab use are being conducted with case reports \[[@B8],[@B9]\]. Controversial opinions still exist regarding the etiology of central serous chorioretinopathy. In recent years, choroidal hyperpermeability has been assumed to be the cause of CSC based upon indocyanine green angiography and has been considered a basis of PDT treatment. Vascular endothelial growth factor (VEGF) is one of the major cytokines that induce vascular hyperpermeability. An intra-ocular injection of anti-VEGF bevacizumab may improve the symptoms of CSC by blocking the activity of VEGF. The effectiveness of this treatment method has been described \[[@B8],[@B9]\]. To date, however, no studies have demonstrated the correlation between hyperpermeability of the choroidal vessel andsomething that might make the pain go away. For grown ups, that something was always a picture book with black and white photographs illustrating how some kid’s pet died. I didn’t lose a pet. I lost my mother. For the life of me, I couldn’t understand why these grown ups didn’t understand the difference any more than I couldn’t understand why no one wanted to see me cry.

The other children looked away when I cried in school while my teacher and the other grown ups tussled my hair into a rat’s nest without saying a word. Rat’s nest is something that my grandmother would say. So many years after she died, I’m still saying silly phrases that I used to hear her say. Yes, there have been a