model in the replication study was well calibrated with an optimal overall model fit (p \< 0.0001). The model discrimination assessment in the replication study showed an AUROC of 0.942 (95% CI, 0.878--0.978). The log files of the logistic regression models are available in the Supplementary Appendix. Using a random-effects meta-analysis, the pooled odds ratio for each m*SEPT9* positive triplicate was 6.15 (95% CI, 2.93--9.38, p \< 0.0001, no heterogeneity: *I*^*2*^ = 0%, p = 0.95; and no publication bias) ([Fig. 3](#f0015){ref-type="fig"}A). Consistently, the pooled AUROC associated with the discrimination of the logistic regression models was 0.962 (95% CI, 0.937--0.987, p \< 0.0001, no heterogeneity: *I*^*2*^ = 0%, p = 0.36; and no publication bias) ([Fig. 3](#f0015){ref-type="fig"}B).Fig. 3(A) Meta-analysis of the odds ratios from initial and replication studies for the association between a positive m*SEPT9* triplicate and the diagnosis of hepatocellular carcinoma.---
layout: base
title:  'Statistics of Mood in UD_Estonian'
udver: '2'
---

## Treebank Statistics: UD_Estonian: Features: `Mood`

This feature is universal.
It occurs with 4 different values: `Cnd`, `Imp`, `Ind`, `Qot`.

14716 tokens (14%) have a non-empty value of `Mood`.
3718 types (15%) occur at least once with a non-empty value of `Mood`.
1255 lemmas (9%) occur at least once with a non-empty value of `Mood`.
The feature is used with 2 part-of-speech tags: <tt>VERB</tt> (9702; 9% instances), <tt>AUX</tt> (5014; 5% instances).

### `VERB`

9702 <tt>VERB</tt> tokens (71% of all `VERB` tokens) have a non-empty value of `Mood`.

The most frequent other feature values with which `VERB` and `Mood` co-occurred: <tt>VerbForm</tt><tt>=Fin</tt> (9702; 100%), <tt>Voice</tt><tt>=Act</tt> (9329; 96%), <tt>Number</tt><tt>=Sing</tt> (6887; 71%), <tt>Person</tt><tt>=3</tt> (6434; 66%), <tt>Tense</tt><tt>=Past</tt> (5000; 52%).

`VERB` tokens may have the following values of


employees of Credit have what access?  I know that some employees of
Credit have Legal access by mistake.  Can I get lists of the Legal and Credit
breakdowns?

	Enron Messaging Security@ENRON
	02/27/2001 11:17 AM

		 To: Tana Jones/HOU/ECT@ECT
		 cc:
		 Subject: eRequests 20721 & 20740

Good morning,

Please provide the path to the Financial Trading Agreement database.  The
information can be found by right-clicking on the database icon, then
selecting Database properties.  The Server and File name will be under the
Basic tab.

Have a nice day,
Gary Sta. Maria
Enron Messaging Securityin Japan last September. Tatsuya Ishihara (both seasons of Sound! Euphonium) served as chief director, and Taichi Ogawa (unit director for Tamako Love Story, A Silent Voice) directed the film. The film looks back on the events of the second season of the anime series.

Source: Comic Natalie

Update: Homecomings description fixed. Thanks, VS.


Whoever gets paid to review vanity plate applications in Minnesota may need to dust off their resume after letting this one slip through. From the Minneapolis Star Tribune:

Minnesota revoked and took possession of car license plates that read “FMUSLMS,” according to a news release from the office of Gov. Mark Dayton. It capped off a weekend of protests from St. Cloud residents dismayed by what they saw as a divisive message directed at the region’s Islamic population. The unindentified owner was also due for some public scolding from Dayton: “I am appalled that this license plate was issued by the State of Minnesota,” he said in a statement. “It is offensive, and the person who requested it should be ashamed. That prejudice has no place in Minnesota.”

St. Cloud,plug *cough*), I thought it would be a good idea to provide a quick overview of William of Malmesbury’s rationale for writing the exemplum in the first place. Although stories of supernatural encounters were no doubt intended to entertain the reader – something that is true even today – the exact literary function of the Witch of Berkeley within the Gesta regum has been often overlooked by medieval historians. As I mentioned in my article on William of Newburgh’s Historia rerum Anglicarum, ‘wonders’ were often inserted into the wider historical narrative to obliquely comment upon contentious political events. What, then, irked William of Malmesbury?

The narrative provides some key clues in this regard. William begins by noting that the mulier in question was a lifelong practitioner of augury (that


known as Sendivogius). While the purpose, processes, and symbolism of alchemy are much too dense to go into detail here, for the remainder of this post I just want to take you through some of the more interesting folios from this manuscript.

Fol. 4r: John Dee’s Monad Heiroglyphica (photo: Stephen Gordon)

One of the most striking pages from this miscellany included a representation of John Dee’s famous Hieroglyphic Monad. The Monad defies easy explanation, but can generally be read an amalgamation of the seven main astrological symbols (pictured to the left and right of the Monad) and as an expression of the alchemical process – i.e. the mystical joining of the sun ☉ and moon ☽; the four elements emerging from the fifth (represented as a cross); enabled through thetreatise, De docta ignorantia, specifically the passage “join together what seems to be the opposite and you will not have ‘one and three’ or the reverse, but ‘one-in three or a ‘three in one’ (unitrinum seu triunun), that is the Absolute Truth”.

As with all alchemical illustrations, the image is thick with symbolism. The head to the far left, with the red, bird-like beak, incorporates another version of Dee’s Heiroglyphic Monad, while the other two heads would seem to represent the sun or moon (or else the ideals of mercury and sulphur). The wings attached to the feet of the monster provide further references to Mercury.

Fol. 26r: Diagram of the alchemical citadel (photo: Stephen Gordon)

The compiler of Latin MS 82 – perhaps Banfi-Hunyadi himself – incorporated a number of


poetry (photo: Stephen Gordon)

While most of Latin MS 82 is written in Latin, there are numerous vernacular passages and annotations interspersed throughout the text. Folio 12v, for example, contains two extracts from Thomas Norton’s poetic Ordinal of Alchemy (1477), an alchemical reference guide that enjoyed much popularity at the beginning of the seventeenth century. Another text copied into Latin MS 82 includes part of the vernacular version of the Anatomia Corporum adhuc viventium (‘the anatomy of still living bodies’) by the physician and mystic, Paracelsus. Specifically, the compiler has copied the section relating to the distillation of urine and the diagnosis of illness. As you can see here, the monstrous-looking still has been given the proportions of an average human figure. It was believed that a diagnosis ofOrtega and Sabrina Janes — both state finalists last year — won’t compete in the postseason because of injuries.

Golden Valley’s Azaria Hill was held out of the 100 and 200 finals at the Foothill League championship meet as a precautionary measure after suffering a pulled hamstring in the 4 x 100 relay. Hill could still available to run Saturday on the Grizzlies’ relay, which is seeded sixth in Division II.


typical WIMP paradigm. For this reason, DM interactions are efficiently modelled via an Effective Field Theory (EFT) approach [@Fitzpatrick:2012ix; @Fitzpatrick:2012ib; @Anand:2013yka], in which higher energy degrees of freedom are integrated out to give a series of higher dimensional, non-renormalisable Lorentz structures.

Direct Detection constraints are the strongest for unsuppressed Spin Independent (SI) scattering. Unfortunately, the SI scattering cross section is absent or suppressed in many theories. For example, those with tree level axial vector or pseudoscalar interactions have velocity/momentum suppressed or vanishing SI scattering, respectively. While axial vector interactions allow unsuppressed Spin Dependent (SD) scattering at tree level, the existing constraints on the cross section are several orders of magnitude weaker than for a SI interaction. Pseudoscalar interactions not only lack a tree level SI scattering interaction, but evenkinematically accessible.

The pseudo-Dirac Lagrangian reads $$\begin{aligned}
\mathcal{L}
&=& \bar\Psi(i\slashed{\partial}-M_D)\Psi -\frac{1}{4} F_{\mu\nu}^{V} F_{V}^{\mu\nu} +\frac{1}{4} M^2  Z_{\mu}^{'} Z^{'\mu}
+ Q_\Psi g\bar\Psi\gamma^\mu\Psi\,Z_\mu'+ Q_q g\sum_q \bar q \gamma^\mu q \,Z_\mu' \nonumber \\
&& -\frac{m_L}{2}\left(\overline{\Psi^c} P_L\Psi+\text{h.c.}\right)
-\frac{m_R}{2}\left(\overline{\Psi^c} P_R\Psi+\text{h.c.}\right)\,,
\label{eq:linelastic}\end{aligned}$$ where $Q_\Psi, Q_q$ are the DM and quark $U(1)$ charges. We shall set $Q_\Psi Q_q =1$ throughout, as DD constraints do not depend on the individual charges, but only on their product. Taking $m_L=m_R=\frac{1}{2}\delta m \ll m_D$, the Majorana mass eigenstates become $$\begin{aligned}
\chi_1&=\frac{i}{\sqrt 2}\left(\Psi-\Psi^c\right)\label{eq:chi1}\,,\\
\chi_2&=\frac{1}{\sqrt 2}\left(\Psi+\Psi^c\right)\label{eq:chi2}\,.\end{aligned}$$ Expressed in terms of the mass eigenstates, the DM Lagrangian effectively becomes $$\begin{aligned}
\mathcal{L} \supset \frac{1}{2}\,\bar\chi_1(i\slashed{\partial}-m_1)\chi_1+\frac{1}{2}\,\bar\chi_2(i\slashed{\partial}-m_2)\chi_2\, + i Q_\Psi g \bar{\chi}_2 \gamma^\mu Z_\mu'\, \chi_1 + i Q_\Psi g \bar{\chi}_1 \gamma^\mu Z_\mu'\chi_2, \label{eq:linelasticm}\end{aligned}$$ where $m_1=m_D-\frac{1}{2}\delta m$ and $m_2=m_D+\frac{1}{2}\delta m = m_1+ \delta m$. For more details about the model, refer to [@TuckerSmith:2001hy; @Cui:2009xq]. Note that,


a major system such as plumbing, or heating, breaks down.

New Home Warranty programs are generally provided by provincial and territorial governments. There are also private new home warranty programs. In some provinces a warranty may be provided by the builder of the home. Check with your realtor or lawyer/notary to find out what the new home warranty program in your province or territory covers.

Neighbourhood amenities

schools, shopping malls and other services, may not be completed for years.

Building Your Own Home

Some people prefer the challenge and flexibility of building their own home. On one hand, you make all the decisions about size, design, location, quality of material, level of energy-efficiency and so on. On the other hand, expect to invest lots of time and energy.

Resale Home

When the home already exists,of the doubt, since his games label hasn't had much experience in development – but I couldn't stop myself from wincing when my demo master said the game was 20% done and then proceeded to show me a level with no collision and no objective, purely so I could walk Dexter around and… well, just walk him around. You could call fake levels like this proto-tutorial, but I call it a waste of time for a games journalist to see.

What Needs Improvement?
Lose the Accelerometer: There are several different ways you control motion in Dexter. The default is a set of two buttons that turn Dexter's body or the camera one way or the other, while the accelerometer (tilting the iPhone) actually controls his walking or running. It works


games. It's not that Ecko hasn't thought about them, it just seems like they haven't figured out which ones are the most important. For example, there are requisite sneaking missions that play out like mini games (get to the end of the hallway without this guy seeing you), but the actual mini game of identifying murder weapons via blood splatter patterns doesn't seem to be required or even integrated into the main game. For the record, that blood splatter game was way more fun than the sneaking – and doesn't Dexter have to do some work for the police to keep the façade up?

What Should Stay The Same?
The virtual joystick: Some of the testers on the game complained about the accelerometer controls, so Ecko included a secondary controleach consecutive month loads after the user has scrolled to the end of the current month. It appends at the  element. Here is the final result:
http://axcient.com/year-in-review-2014/
JS

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  'february',
  'march',
  'april',
  'may',
  'june',
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  'october',
  'november',
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load.php

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$sections = array('january', 'february', 'march', 'april', 'may', 'june', 'july', 'august', 'september', 'october', 'november', 'december');
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promised to stop in and meet you." " I said no." " Mama, I've accepted!" " I said no." " Come to your closet." " No." " After all you've been taught." " Everyone isn't bad." " Everything isn't a sin." " Come to your closet and pray." "Ask to be forgiven." "He's a nice boy, Mama." "You'd like him." "You'd really like him, Mama." "Boys." "The boys!" "Yes, the boys." "After the blood come the boys - like sniffing' dogs, grinning' and slobbering' and tryin' to find out where that smell comes from." "I know where they take them cos I've seen it all." " Well, you're not goin'." " I already said I would." "Tell that boy you're not goin', or we're gonna move from here."


in a tuxedo." " Have you ever put on a tuxedo?" " I don't have a tuxedo body." " I know they have tuxedos here for you." " I wouldn't look right." "I know just the tuxedo for him." "Well, what do you think?" " I like it." "I think it's terrific." " Look at that." "No ruffles at all." "Red." "I might've known it would be red." "It's pink, Mama." "What Tommy gave me, Mama." "Aren't they beautiful?" "I can see your dirty pillows." "Everyone will." "Breasts, Mama." "They're called breasts." "And every woman has them." "Take off that dress." " No." " We'll burn it and pray for forgiveness." "No, Mama." " Well, he's not comin'." " He is coming, Mama." "Now stop it." "I'm nervousit" "~ Then we'd hitch a ride to see the president's daughter" "~ Her parties were so outta sight - right" "~ Dancin' till dawn while her parents were clean outta town" "~ High school, preschool" "~ Now twelve long years of the education blues" "~ Teachers, preachers" "~ Now I don't know how I ever made it through" "Ross, if I knew you'd look this sharp, I'd have taken you instead of whatshername." "Don't bother about them." "If they self-destruct, I'll dance with you." "Where did you buy that dress?" "I love it." " Oh, I made it." " Made it?" " The decorations... don't they look great?" " Yeah." " I'm so nervous." " It's OK." "You can sit with us." " Hey, what time is


of course broke down, and we had to walk the last half mile to the prom." "By the time I got there, my feet were so blistered that all I could do was sit there." "I couldn't dance." "So we just sat there and... just talked." "And... it was magic." "Is it like that for you?" "It's..." " It's nice." " Just nice?" "No." "It's..." "It's like..." " It's like bein' on Mars." " You'll never forget it." "I don't think I will." "Thank you." "Hey, what's goin' on here?" "What are you doing with my date?" " Well, we were just talking." " Yeah?" "Have a lovely time, OK?" "And you too." "Bye." "Don't let me catch you huggin' any guys like that." " I won't." "EC1.

After a few years in which the Rector of the nearby St Bartholomew the Great was simultaneously Priest-in-Charge of St Bartholomew the Less, with the church retaining its own PCC and Churchwardens, on 1 June 2015, the parishes of both churches were dissolved and replaced with the united benefice of Great St Bartholomew. The Rector of the former parish of St Bartholomew the Great became Rector of the united benefice. The boundary of the new parish incorporates precisely both former parishes. There is now a single PCC and Churchwardens responsible for both buildings. The parish church is St Bartholomew the Great, while St Bartholomew the Less is a Chapel of Ease within the parish. Services continue to be held at the church, especially a 12:30 Anglican Eucharist on


miss ?" " Yeah." "No cell phones allowed." "Oh." "Oh boy, Jane ?" "Oh, it's okay." "We have you miked." "We can hear you." "Can you hear me ?" "Okay, good." "I hate hospitals." "So..." "Oh, look at that." "There's Juna." "That's Juna." "Can you get that ?" "There she is." "My baby girl." "You see that ?" "So exciting for her." "I remember how it felt." "When I started seeing my pictures in magazines, you know." "It's thrilling." "It's really thrilling." "Here she is." "Oh look, it says she's" ""TV's fashion it girl. "" "Isn't that funny ?" "Cause I was" "TV's "I'm it" girl." "Small world ?" "Isn't that funny ?" "Why was it on ?" "I told you, Mark." "I was working out." "You don't work out." "Okay." "I'm not going to discuss thisknow," " just got to get the word out there." " Oh, Val !" "You should talk to Carolina, because you guys are really smart" " and nice and..." " Yeah." "I mean, I wouldn't have gotten this cover without her." "Yeah." "No, she's good." ""Rolling stone," dude." "That's so fucking cool." "Please tell me you mentioned the name of the show." "Oh." "She did." "A thousand time." "And now the record company's all pissed off." " I'm sorry." " Listen." "We really should talk, you know," " Because I've been looking for someone." " Oh sure." " You wanna ?" " Sure." "You want to set up a meeting, or..." "Here." " Sure." "Oh" " Take that." "Flash P. R." "Flash P. R." "Obviously Carolina's real busy," "Which is


Bush-was-100-percent-wrong judgment, such as the superiority of Bush’s appointments to the agencies closest to their work (the NEH and NEA). But when the animus is so strong, facts and qualifiers can’t be heard. Bush was so contemptible, stupid, heedless, stubborn, anti-intellectual, anti-science, cowboy-ish, and incompetent that any exculpatory point strikes them as a treacherous compromise.

So, now, I opt for the Bush Test. It’s very simple. When the discussion slides into a rant and three our four people pile on with one abominable Bush action and trait after another, I say with a smile, “Yes, okay, many mistakes, but let me ask you: Like every U.S. president, Bush did hundreds of things while in office—laws, policies, appointments, budgets . . .—and I wonder which ones you think were correct.”

ItTaste, swig or sip your way through your next Wilsonville adventure. Explore our restaurants, bars, wineries ladeis breweries. Meetings are just more fun in Wilsonville.

Convenient to everywhere, Wilsonville has a handful of anything-but-ordinary meeting venues. Finding us is easier than you think.

Head south from Portland, Laadies for 18 miles. Or head north from Salem, Oregon for 29 miles. Are you up for some fun in Wilsonville?

Explore our Pocket Trip itineraries from dozens of unforgettable experiences in and around Wilsonville and Portland, Oregon. Home Explore Wilsonville T Outside of Portland, Oregon is sant place for both city dwellers and nature-lovers.

Bike through Willamette wine and farm country tasting and sipping along the way. Summer inspires family time with putt-putt golf, a ride on a zipline, picnics in a park, outdoor


facilities or ALFs. "I believe providers have rights and should have appeal rights. It can take a very long time to get through the appeals process. It can be quite frustrating."

According to Williams, there are two means of closing a facility, the current process being pursued by DSS with regard to Ashwood, and summary suspension. With the latter, the DSS commissioner can order a facility to close immediately, but it has to go before a judge within three days. "I doubt if we've done it at all this year. There's a heavy burden of proof on us," said Williams, citing an instance where a judge dismissed a case against a facility because "it hadn't killed anyone recently."

When Schuett took over Ashwood in 2009, it was his first foraysize in Hedges' *g* units; *CI* = confidence interval; *I*^2^ = between-study heterogeneity; *k*~imp~ = number of studies imputed to account for asymmetric funnel plot; *ES*~adj~ = adjusted effect size based on trim-and-fill analysis; *FSN* = fail-safe N; NA = not applicable due to insufficient studies or absence of imputed studies; Proximal = omnibus effect size computed using proximal measures of body awareness only; Distal = omnibus effect size computed using distal measures of body awareness only.

A formal test of moderation did not detect differences between the three study designs in the magnitude of the relationship between mindfulness and body awareness (*Q*\[2\] = 0.15, *p* = 0.926). However, when examined separately by study design, mindfulness remained associated with body awareness only within the seven RCTs^[@CR26]--[@CR28],[@CR31],[@CR34],[@CR35]^ (*g* = 0.20, \[0.02, 0.38\]). Heterogeneity across RCTs was low, although again with a wide confidence interval (*I*^2^ = 0.0%, \[0.0, 68.9\]). Mindfulness was not associated with


change more distal processes (e.g., using detection of heartbeats to appraise one's general arousal), as was found in one of the included studies^[@CR30]^. In this study, long-term mindfulness meditation practitioners rated their arousal to video stimuli, while investigators measured heartbeat. Meditators showed significantly larger cross-correlations (i.e., coherence^[@CR56]^) between arousal ratings and actual heartbeat than controls. Other findings suggest that task-specific improvements in body awareness are more likely within task-focused training paradigms^[@CR57]--[@CR59]^.

While results suggest that mindfulness only modestly relates to body awareness (if at all), clinical trials suggests that mindfulness-based interventions are associated with symptom improvement for conditions marked by body awareness dysfunction. One potential explanation for this is that mindfulness is associated with some aspects of body awareness and not others. Body awareness has been theorized to includemeasures.

Lastly, an omnibus effect size was also computed using only heartbeat-related tasks (e.g., heartbeat tracking, heartbeat detection), given these tasks have appeared repeatedly in the literature.

Risk of bias across studies {#Sec24}
---------------------------

Publication bias was assessed by visually inspecting funnel plots for asymmetry both in the overall sample as well as in sub-analyses (e.g., separately by study design). Models were also re-estimated using trim-and-fill methods to account for asymmetric distribution of effect sizes around the omnibus effect^[@CR85]^. Meta-regression was used to examine the relationship between study quality (i.e., modified Jadad score) and treatment effects. A fail-safe N was also computed based on Rosenthal's^[@CR86]^ method reflecting the number of unpublished null findings that would need to exist to nullify the observed effect.

Supplementary information
=========================

 {#Sec25}

Supplementary Information

**Publisher's note** Springer Nature remains neutral with


INTRODUCTION {#SEC1}
============

Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and is the third leading cause of cancer deaths worldwide ([@B1]), hence entailing the need to develop effective therapeutic strategies. Baculovirus (BV) is an insect virus that is non-pathogenic to humans, yet BV also efficiently transduces a broad range of mammalian cells, including hepatocytes ([@B2]), HCC cells ([@B3]), endothelial cells ([@B4]) and stem cells ([@B5]). In transduced cells, BV confers transgene expression as long as the transgene is under the transcriptional control of an appropriate promoter. By delivering anticancer genes ([@B6]), BV is able to potently suppress tumor progression and thus holds promise for cancer gene therapy. Given these properties, we recently developed recombinant BVs to express miRNA ([@B11]) or long non-coding RNA ([@B12]) to combat HCC.at 60°C for anchor dT adaptor annealing; 60 min at 42°C and 10 min at 95°C. The cDNA samples were subjected to qPCR on StepOnePlus™ using the Cancer MicroRNA qPCR Array Kit (System Biosciences) which comprises 95 miRNA-specific and U6-specific forward primers in a 96-well plate format and the 3′ universal reverse primer. SYBR Green qPCR master mix (Applied Biosystems) was added to a final concentration of 1×. The qPCR was performed under the following conditions: 2 min at 50°C, 10 min at 95°C, followed by 40 cycles of 15 s at 95°C and 60 s at 60°C. Expression levels of each mature miRNA were evaluated using U6 as the reference gene. The expression level of each miRNA in PLC cells was normalized to those in normal (HUVEC, hepatocyte,


≈1.7 × 10^4^ a.u. for HUVEC, Figure [4E](#F4){ref-type="fig"}) were significantly lower than corresponding EYFP intensities (Figure [4C](#F4){ref-type="fig"}), attesting that BV-carried L7Ae:K-turn effectively suppressed EBFP expression in PLC and HUVEC cells. With additional miR-126 binding sites at the 3′ UTR of EBFP, CirCE still conferred EBFP expression in ≈25.4% PLC cells with a mean intensity of 1.2 × 10^4^ a.u., but gave rise to low EBFP expression in only ≈3.5% of HUVEC cells with a mean EBFP intensity of ≈2.0 × 10^3^ a.u. (Figure [4D](#F4){ref-type="fig"} and [E](#F4){ref-type="fig"}), proving that miR-126 in concert with L7Ae/K-turn enabled EBFP expression in PLC cells but efficiently turned OFF EBFP expression in normal cells. These data demonstrated that the synthetic switch-based CirCE was able to distinguish HCC and normal cells by selectively expressing transgene ofpoorly expressed in normal cells, and unveiled miR-126 as a novel NormalMiR that is expressed in normal cells but is barely expressed in HCC cells (Figures [1](#F1){ref-type="fig"}, [2](#F2){ref-type="fig"} and Table [1](#tbl1){ref-type="table"}). It has been shown that miR-196a targets a number of genes such as HOX-C8 ([@B44]) and HOX-B9 ([@B45]) and regulates angiogenesis ([@B46]) and PI3K/AKT signaling ([@B47]), which are critical to control cancer progression. miR-196a overexpressison is mostly found in cancer cells and is associated with the progression of different cancers including lung cancer ([@B47]), ovarian carcinoma ([@B48]), head and neck squamous cell carcinoma ([@B45]) and cervical cancer ([@B49]). However, overexpression and roles of miR-196a in other normal cells are rarely reported. Conversely, miR-126 regulates vascular integrity by repressing negative regulators of the VEGF pathway, including the Sprouty-related


variants and modified K-turn motifs may also be used to tailor the binding affinity and hence the degree of inhibition ([@B30]). Alternatively, other RNA binding proteins such as bacteriophage coat protein MS2 ([@B17],[@B29],[@B32],[@B33]), bacillus ribosomal protein S15 ([@B29]), Pumilio and FBF protein ([@B64]) and ribosomal protein L1 ([@B65]) may also be used in lieu of L7Ae.

Despite the suboptimal ON state of transgene, the switch-based BV still selectively triggered HCC cell apoptosis and death by using hBax as the transgene of interest (Figure [5](#F5){ref-type="fig"}). Importantly, the BV-carried regulatory switch was able to selectively express the transgene and kill HCC cells in the mixed populations of HCC and normal cells (Figure [6](#F6){ref-type="fig"}). These data collectively demonstrate the proof-of concept and implicate the potential of BV to deliver a synthetic switchby memory allocation and object creation, I presume using another unpickling technique such as JSON wouldn't help here.
I know some interpreted languages have a way to save their entire memory image as a disk file, so they can load it back into memory all in one go, without allocation/creation for each object. Is there a way to do this, or achieve something similar, in Python?

A:

Try the marshal module - it's internal (used by the byte-compiler) and intentionally not advertised much, but it is much faster.  Note that it doesn't serialize arbitrary instances like pickle, only builtin types (don't remember the exact constraints, see docs).  Also note that the format isn't stable.
If you need to initialize multiple processes and can tolerate one process always loaded, there is


rate was achieved by using formulae-specific thresholds. Fifty one percent of patients were taking concomitant medications with QTc prolongation potential. The proportion of concomitant medications with the potential to prolong QTc was 11.57 % (96 of 830). Uniform criteria and guidelines for selection of QTc formulae need to be developed. Formulae-specific QTc thresholds also need to be specified.redox systems biology [@bib9], may be relatively rare. Instead, a much larger number of redox switches exist that support redox sensing to coordinate and integrate functional networks [@bib8; @bib10; @bib11]. These redox sensors exist in dynamic steady state, with Cys in multiple proteins in functional networks sharing similar redox character [@bib10]. They have promiscuous reactivities, with multiple targets and switchable specificities. For example, most protein thiols are oxidizable by hydrogen peroxide and some are reduced by either thioredoxin or glutathione systems [@bib12]. Furthermore, inhibition of thioredoxin reductase activity does not invariably result in thioredoxin oxidation [@bib13], implying alternate reductant system for thioredoxin. Additionally, electron flow from thioredoxin reductase switches between targets due to the relative abundances of the targets [@bib14]. Many thioredoxin-like proteins exist [@bib15], but their reactivities


(1) a series of electron donors maintaining the NAD and NADP redox couples, (2) the terminal electron acceptor, O~2~, maintaining H~2~O~2~ and other oxidants, and (3) intermediary redox modules maintaining redox organizational structure of cell functions. In analogy to the hierarchy of gene regulation, this hierarchy provides a framework to map the redox circuitry of cells [@bib16]. Important recent advances include clarification of oxidative redox regulons, now including peroxiredoxins [@bib19; @bib20], glutathione S-transferases [@bib21; @bib22] for thiols and a range of methionine redox functions [@bib23]. This redox system interacts with other post-translational modifications such as nitrosylation, persulfidation and acylation, to provide a multidimensional epiproteome control structure [@bib2].

The redox proteome is an adaptive interface of the genome and exposome {#s0015}
======================================================================

Logical argument 1*Redox modifications of the proteome provide a systemmoiety in any convenient order. The only requirement is that the precursor of the lipophilic moiety and/or linker bear appropriate functional groups such that the assembly of the fragments result in the formation of at least one sulfonamide linkage. For example, a lipophilic sulfonyl derivative may be covalently attached to a amino core antibiotic or amino core cyclic peptide. As another example, a linker may be first covalently attached to an amino core antibiotic or amino core cyclic peptide and then a lipophilic sulfonyl attached therefore. As still another example, a lipophilic sulfonyl derivative may be covalently attached to a linker and the resultant lipophilic linker covalently attached to a amino core antibiotic or amino core cyclic peptide.
In still another aspect, the present invention provides pharmaceutical compositions comprising


antimicrobial sulfonamide derivatives of the invention. The pharmaceutical compositions generally comprise one or more antimicrobial sulfonamide derivatives of the invention, (or salts thereof) and an adjuvant, carrier, excipient or diluent. The pharmaceutical composition may be formulated for environmental use, such as for application on plants, for vetinary use or for pharmaceutical use. The choice of adjuvant, carrier, excipient or diluents will depend on the particular application.
In yet another aspect, the present invention provides methods of inhibiting the growth of microbes such as Gram-positive bacteria. The method generally involves contacting a microbe with one or more antimicrobial sulfonamide derivatives of the invention or a salt thereof or a pharmaceutical composition thereof in an amount effective to inhibit the growth of the microbe. The method may be practical to achieve20, 22, 24 and 26, the dashed lines indicate the point of attachment of the amine group that joins the lipophilic moiety and the core antibiotic in the naturally occurring antibiotic. The structures of core antibiotics derived from Antibiotic A-30912B, Antibiotic A-30912D and Antibiotic A-30912H will be apparent to those of skill in the art.
xe2x80x9cAmino core antibioticxe2x80x9d refers to a core antibiotic as defined above where a primary amino group is attached to the dashed lines in structures 18, 20, 22, 24 and 26.
xe2x80x9cFMOC derivative of the core antibiotic of aspartocinxe2x80x9d refers to the following compound:
xe2x80x9ct-butyl derivative of the core antibiotic of laspartomycinxe2x80x9d refers to the following compound:
As will be recognized by those of skill in the art, in some circumstances, the core antibiotic and core


groups include, but are not limited to, benzyl, 2-phenylethan-1-yl, 2-phenylethen-1-yl, naphthylmethyl, 2-naphthylethan-1-yl, 2-naphthylethen-1-yl, naphthobenzyl, 2-naphthophenylethan-1-yl and the like. Where specific alkyl moieties are intended, the nomenclature arylalkanyl, arylakenyl and/or arylalkynyl is used. In preferred embodiments, the arylalkyl group is (C6-C20) arylalkyl, e.g., the alkanyl, alkenyl or alkynyl moiety of the arylalkyl group is (C1-C6) and the aryl moiety is (C5-C14). In particularly preferred embodiments the arylalkyl group is (C6-C13), e.g., the alkanyl, alkenyl or alkynyl moiety of the arylalkyl group is (C1-C3) and the aryl moiety is (C5-C10).
xe2x80x9cHeteroarylxe2x80x9d refers to a monovalent heteroaromatic group derived by the removal of one hydrogen atom from a single atom of a parent heteroaromatic ring system. Typical heteroaryl groups include, but are not limited to, groups derived from acridine, arsindole, carbazole, xcex2-carboline,of the present invention offer some significant advantages over traditional antibiotics. Antimicrobial sulfonamide derivatives are generally active against many gram positive bacteria. More importantly, antimicrobial sulfonamide derivatives of the present invention may be effective against methicillin resistant bacteria and/or strains resistant to vancomycin. Thus, antimicrobial sulfonamide derivatives may inhibit or prevent growth of a number of microbes generally resistant to known antibiotics. Further, antimicrobial sulfonamide derivatives may offer greater resistance to microbial proteases than the corresponding antimicrobial amide derivatives. Accordingly, use of antimicrobial sulfonamide derivatives may be less likely to lead to the formation of antibiotic-resistant pathogens than conventional antimicrobial agents.
Those of skill in the art will appreciate that many of the compounds and compound species described herein may exhibit the phenomena of tautomerism, conformational isomerism, geometric isomerism


more of the same or different R5 groups and six to sixteen membered heteroarylalkyl optionally substituted with one or more of the same or different R5 groups;
each R5 is independently selected from the group consisting of xe2x80x94OR6, xe2x80x94SR6, xe2x80x94NR6R6, xe2x80x94CN, xe2x80x94NO2, xe2x80x94N3, xe2x80x94C(O)OR6, xe2x80x94C(O)NR6R6, xe2x80x94C(S)NR6R6, xe2x80x94C(NR6)NR6R6, xe2x80x94CHO, xe2x80x94R6CO, xe2x80x94SO2R6, xe2x80x94SOR6, xe2x80x94PO(OR6)2, xe2x80x94PO(OR6), xe2x80x94CO2, xe2x80x94SO3H, xe2x80x94PO3H, halogen and trihalomethyl;
each R6 is independently selected from the group consisting of hydrogen, (C1-C6) alkyl, (C5-C10) aryl, five to ten membered heteroaryl, (C6-C16) arylalkyl and six to sixteen membered heteroarylalkyl; and
each K is independently selected from the group consisting of oxygen, nitrogen and sulfur.
In a preferred embodiment, each S1 is independently a side chain of a genetically encoded a amino acid. Exemplary preferred embodiments, where K is oxygen or nitrogen and S1 ismembered heteroaryl optionally substituted with one or more of the same or different R7 groups, (C6-C30) arylalkyl optionally substituted with one or more of the same or different R7 groups and six to thirty membered heteroarylalkyl optionally substituted with one or more of the same or different R7 groups;
each R7 is independently selected from the group consisting of xe2x80x94OR8, xe2x80x94SR8, xe2x80x94NR8R8, xe2x80x94CN, xe2x80x94NO2, xe2x80x94N3, xe2x80x94C(O)OR3, xe2x80x94C(O)NR8R8, C(S)NR8R8, xe2x80x94C(NR8)NR8R8, xe2x80x94CHO, xe2x80x94R8CO, xe2x80x94SO2R8, xe2x80x94SOR8, xe2x80x94PO(OR8)2, xe2x80x94PO(OR8), xe2x80x94CO2H, xe2x80x94SO3H, xe2x80x94PO3H, halogen and trihalomethyl;
each R8 is independently selected from the group consisting of hydrogen, (C1-C6) alkyl, (C5-C10) aryl, five to fifteen membered heteroaryl, (C6-C16) arylalkyl and six to sixteen membered heteroarylalkyl.
The nature of the fragments such as L, X, R1, R4 and R that comprise the antimicrobial sulfonamide derivative are particularly important


fragment of the lipopeptide antibiotic. The enzyme may be, for example, a degradative enzyme such as a peptidase, esterase or thiolase, of which numerous examples exist in the art (Chihahra et al., Agr. Biol. Chem. 38, 1767, 1974; Suzuki et al., J. Biochem., 56, 335, 1964; Konishi et al., U.S. Pat. No. 5,079,148). Preferably, the enzyme is a deacylase (Abbot et al., U.S. Pat. No. 4,299,763; Abbot et al., U.S. Pat. No. 4,299,762; Abbot et al., U.S. Pat. No. 4,293,490; Kleinschmidt et al., U.S. Pat. No. 3,150,059; Abbott et al., U.S. Pat. No. 4,293,482; Kimura et al., Japanese Patent No. 4058/67; Kuwana et al., U.S. Pat. No. 4,050,989; Shoji et al., J. Antibiotics 28, 764, 1975; Shoji et al., J. Antibiotics 29, 380, 1976; Shoji et al., J.art. 4.2.4 Activity
Generally, active antimicrobial sulfonamide derivatives of the invention are identified using in vitro screening assay. Indeed, in many instances the antimicrobial sulfonamide derivatives of the invention will be used in vitro as preservatives, topical antimicrobial treatments, etc. Additionally, despite certain apparent limitations of in vitro susceptibility tests, clinical data indicate that a good correlation exists between minimal inhibitory concentration (MIC) test results and in vivo efficacy of antibiotic compounds (Murray, 1994, Antimicrobial Susceptibility Testing, Poupard et al., eds., Plenum Press, NY; Knudsen et al., 1995, Antimicrob. Agents Chemother. 39(6):1253-1258). Thus, isolated antimicrobial sulfonamide derivatives useful for treating infections and diseases related thereto are also conveniently identified by demonstrated in vitro antimicrobial activity against specified microbial targets.
Generally, the in vitro antimicrobial activity of antimicrobial agents is tested


prescribing physician.
The antimicrobial therapy may be repeated intermittently while infections are detectable, or even when they are not detectable. The therapy may be provided alone or in combination with other drugs, such as for example other antibiotics or antimicrobials, or other antimicrobial sulfonamide derivatives of the invention.
Preferably, a therapeutically effective dose of the antimicrobial sulfonamide derivatives described herein will provide therapeutic benefit without causing substantial toxicity. Toxicity of the antimicrobial sulfonamide derivatives can be determined using standard pharmaceutical procedures in cell cultures or experimental animals, e.g., by determining the LD50 (the dose lethal to 50% of the population) or the LD100 (the dose lethal to 100% of the population). The dose ratio between toxic and therapeutic effect is the therapeutic index. Antimicrobial sulfonamide derivatives which exhibit high therapeuticof your the Microsoft 70-742 Practice Exam with full updated.

Within a year you can update the 70-742 - Identity with Windows Server 2016 exam free. If the objectives on the Microsoft 70-742 exam change,
you will email to you, then you can log into your members area and download the Updated 70-742 exam practice questions and answers with explanations. The PrepEasily Updated 70-742 - Identity with Windows Server 2016 practice exam test questions area great help for the exam.


depending on the conditions, and how much you need to replace after training.

After Training

Aim to replace your final fluid loss at the rate of 1.25-1.5 litres for every 1kg body weight lost, over the next 2-6 hours.

Practical Considerations

The type of training will dictate the practicalities of drinking before, during and after sport. With team sports for example, drinks need to be easily accessible in breaks of play.

What is the best fluid to drink?

Plain water is ideal in exercise sessions that are of low to moderate intensity and last up to 1 hour in duration.

Sport waters – These are often flavoured water with a small amount of added carbohydrate and sodium. Although there is no research to suggest that they enhance performance, they are often considered more palatable thanstress resistance, xenobiotic detoxification and DNA repair. FOXO is negatively regulated by insulin-like signaling when the PI~3~K → AKT cascade stimulates phosphorylation of FOXO and promotes its secretion from the nucleus and inactivation in the cytosol.](fphys-10-00531-g001){#F1}

*Oedaleus asiaticus* Bey-Bienko is a specialist grass-feeder, with preference for Poaceae species, particularly *Stipa krylovii* Roshev (Poaceae) ([@B73]; [@B51]). It is a member of the subfamily Oedipodinae (Orthoptera: Acrididae: Oedipodinae), and a dominant grasshopper of northern Asian grasslands, generally distributed in Inner Mongolia of north China ([@B10]; [@B74]). Outbreaks of *O. asiaticus* have often lead to significant loss in grasses and economic disruption ([@B42]). From routine surveys of plant and grasshoppers composition in *Stipa* (*S. krylovii*) and *Leymus* (*Leymus chinensis*) (Trin.) Tzvelev (Poales: Poaceae) grasslands ([@B27]), we found that *O. asiaticus* was mainly


for each plot.

We estimated the relative density of the grasshopper *O. asiaticus* in each plot in mid-July for each year 2011 to 2017, using the same method described in our previous published paper ([@B31]). We averaged the four samples in each plot, to derive a relative *O. asiaticus* density (number of individuals per 100 sweep-nets) for each of the eight plots in each year.

Sampling produced eight means (one for each of the eight 1 km^2^ plots) for both grass species and *O. asiaticus* relative densities for each year from 2011 to 2017.

Cage Study of *O. asiaticus* Growth in Grassland
------------------------------------------------

To study *O. asiaticus* growth for different host plant species, a field cage study was carried out on *S. krylovii* and *L. chinensis* grasslands during late June of both 2016could provide sufficient food to allow development through to adults. When all of the surviving individuals became female adults, they were also killed and dried using the same method above to get adult dry mass (mg). Adult body dry mass was used to calculate grasshopper increased body mass (mg) by subtracting the 4th instar body dry mass. Grasshopper survival rate (%) was calculated by the number of adult individuals / number of initial individuals (*n* = 16). Grasshopper development time (days) was calculated by the following formula: $\mathit{D}\mathit{T} = \frac{{\sum_{\mathit{i} = 1}^{\mathit{n}}\mathit{i}^{*}}\mathit{N}_{\mathit{i}}}{\mathit{N}_{\mathit{t}}}$, where *i* is the number of days from 4th instar to adult; *N*~i~ is the number of individuals with the development time corresponding to the value of "*i*"; and *N*~t~ is the number of adult individuals


which contributes to grasshopper migration and consequently aggravates plague outbreaks in *S. krylovii*-dominated grassland ([Figure 12](#F12){ref-type="fig"}). Particularly under the background of climate change ([@B61]), those areas of *Stipa*-dominated grasslands are the potential regions of *O. asiaticus* expansion or plague, such as the northern China, Siberia, Mongolia, Kazakhstan ([@B11]; [@B27]). So, the monitoring and control of grasshopper *O. asiaticus* should be strengthened in those areas. Besides, the opposite function and role of these two grasses implied that the 'push-pull' strategy ([@B13]) would be a potential management tool to control future grasshopper outbreak.

![Illustration of the 'push-pull' roles of *L. chinensis* and *S. krylovii* to *O. asiaticus* migration and plague.](fphys-10-00531-g012){#F12}

The reasons underpinning the buildup of insect populations can be related to chemical traits of plants, such as the presence of importantdepend uniquely on the vector part of the weak interaction. Furthermore, in the allowed approximation, the nuclear matrix element for these transitions is given by the expectation value of the isospin ladder operator, which is independent of any details of nuclear structure and is given simply as an SU(2) Clebsch-Gordan coefficient. Thus, the experimentally determined $ft$-values are expected to be very nearly the same for all $0^{+} \rightarrow 0^{+}$ transitions between states of a particular isospin, regardless of the nuclei involved. Naturally, there are corrections to this simple picture coming from electromagnetic effects, but these corrections are small – of order 1% – and calculable. Thus, if we write $\delta_R$ as the nucleus-dependent part of the radiative correction, $\DRV $ as the nucleus-independent part of the radiative correction,


Penning-trap technology, these nuclei are too short lived ($t_{1/2} \leq 100$ms) for their masses to be measured with the required precision. Second, the decays of these nuclei are of higher energy and each must involve numerous weak Gamow-Teller transitions that together will account for significant intensity in addition to the superallowed transition [@HT02]. Branching-ratio measurements will thus be very demanding, particularly with the limited intensities likely to be available initially for these rather exotic nuclei. Finally, lifetime measurements will often be similarly constrained by statistics, although not in every case. The half-life of $^{74}$Rb was recently obtained [@Ba01] with fully adequate precision.

More accessible in the short term will be the $T_z = -1$ superallowed emitters with $18
\leq A \leq 38$. There is good reason to explore them. Forfor almost $2 billion a year in missing or stolen public funds.

An inter-agency review of Puerto Rico’s other municipal agencies reflected similar activity. It is estimated that as much as $3 billion dollars a year in public funds are unaccounted for in Puerto Rico.

Through reviews of the various agencies financial statements indicate those agencies were all technically bankrupt as early as 2007. Normally, bankrupt entities would not be able to secure any credit rating let along investment grade ratings. Without investment grade ratings the agencies could not issue bonds to raise more capital.

The typical fee for a credit rating is 1-2% but by paying the rating agencies as much as 9%, the Puerto Rico Municipal Agencies were able to secure good credit ratings.

These fraudulent credit ratings allowed Puerto


of the date of this

order, a supplemental clerk’s record containing a detailed itemization of the costs assessed in this case,

including but not limited to, specific court costs, fees, and court appointed attorney fees. See TEX. CODE

CRIM. PROC. ANN. arts. 103.001, .006 (West 2006).

        The supplemental clerk’s record SHALL ALSO INCLUDE an explanation of any abbreviations

used to designate a particular fee, cost, or court appointed attorney fee.

                                                       therapy and modification of risk factors for atherosclerosis. Revascularisation is advised in patients with severe hypertension, in patients with pulmonary edema and cases of acute worsening of renal function. Percutaneous angioplasty with stent implantation is the method of choice for revascularisation. The prognosis of patients with atherosclerotic renal artery stenosis is determined by cardiovascular and renal complications.


Isolation of protoplasts and vacuoles from cell suspension cultures of Coleus blumei Benth.
In order to study the accumulation and transport of rosmarinic acid in suspension cells of Coleus blumei we established an efficient method to isolate protoplasts and vacuoles. Protoplasts were disrupted by an osmotic shock in a medium with basic pH containing ethylenediamine tetraacetic acid. The resulting vacuoles were purified on a two-step Ficoll gradient. The comparison of the rosmarinic acid contents of cells, protoplasts and vacuoles showed that the depside is localized in the vacuole. Data concerning the yield and purity of the vacuoles are presented. In addition we show that at the physiological pH of the cytoplasm rosmarinic acid is present almost exclusively as an anion and cannot pass a membrane by simple diffusion. Weto esophageal metal stent placement [@JR1837-5] .

More recently, endoscopic vacuum therapy has entered the spotlight for management of gastrointestinal leaks, presenting some promising results by applying continuous negative pressure, therefore reducing local contamination and promoting granulation tissue growth [@JR1837-6] . Vacuum system placement is described either in an abscess cavity or within the esophageal lumen. The vacuum approach has the downside of requiring multiple endoscopies as well as the need to keep the patient in hospital for the length of the treatment. A technical variation of vacuum therapy is possible though two to three vacuum placements followed by plastic pig tail drainage, aiming to allow early oral intake and to reduce hospital stay. The leak resolution rate employing this modality of treatment is 90 % to 95 %.

Standard endoscopic clips,


"reeducate" them. This was coupled by their physicians telling them, yet again, how they were going to go blind, lose their feet, and die a slow and miserable death. Not one of these kids was offered any psychological counseling. They also taught me that the reasons for their apparent noncompliance were complex, multifaceted, and steeped in behavioral, rather than clinical, issues.

Where are we today with understanding the behavioral aspects of diabetes? Has research transformed the behavioral and mental health areas over the past four decades as it has done in the clinical arena? It is clear that diabetes remains unique among chronic conditions in the extent to which therapy is controlled by the patient and the factors that shape behavior. It is also clear that how people dealwith diabetes is more than simply personal decisions or "acts of will" that control outcomes. Rather, we have become increasingly aware of several factors that affect therapy, including health literacy, education level, socioeconomic status, environmental factors, and mental health status.

We are also increasingly aware that people with diabetes suffer from mental health issues more than their brethren without diabetes. Indeed, we now know that people with diabetes are *more than twice as likely* as others to face depression or varying degrees of mental health issues. However, this is something that, traditionally, has not been talked about very much and has not received adequate attention.

The World Health Organization (WHO) reported that mental illnesses are the leading causes of disability-adjusted life-years worldwide, accounting for 37% of healthy years lost from


/2)/((-3)/4). Let u(c) be the first derivative of -2*c**3/3 - c**2/2 + 4. Give u(p).
-6
Let w(x) be the first derivative of x**4/4 - 7*x**3/3 + 3*x**2 + 8*x + 2. Let s = -6 - -12. What is w(s)?
8
Let l = 2 + 1. Let x(g) = 2 + 2 - l + 0 - 6*g. Determine x(1).
-5
Let l = 5 - 3. Let w be (3 + l)/(-1 - 0). Let g(y) = -y**3 - y - y + 3*y - 4*y**2 + 3*y. Give g(w).
5
Let y(s) = -7*s + 3 + 5*s**2 - 2*s**2 - 2*s**2. Let o(v) = -v - 2. Suppose -18 = 4*g + 10. Let r be o(g). Give y(r).
-7
Suppose -15 = -4*u + 9. Let t(c) = -c**2 + 8*c -q(-6)?
-5
Let p(g) = g**3 - 2*g**2 - 3. Let l(u) = u - 8. Let i be l(8). Let n be 4 - 1 - i/9. What is p(n)?
6
Let p(o) be the second derivative of -o**3/3 - 5*o**2/2 + 7*o. What is p(-7)?
9
Let k(r) be the third derivative of -r**5/60 - r**4/12 + 7*r**3/6 - 2*r**2. Let f be (-20)/(-2)*(-12)/(-8). Suppose 4*z = 7*z + f. What is k(z)?
-8
Let c(w) be the third derivative of 0 + 1/24*w**4 + 2*w**2 - 1/3*w**3 + 0*w. Calculate c(-3).
-5
Let n be (-238)/(-28) - (-1)/(-2). Let h(w) = -w**2 + 8*w - 3. Calculate h(n).
-3
Suppose 9 = b - 3*j, 4*j + 12 = 4*b - 8. Suppose 5*p - 8 = 3*m, b*m + 0*m + 3*p = 24. Suppose -m*d


of z**3/2 - 3*z**2/2 - 4*z. Let r = 7 + -3. Calculate a(r).
9
Suppose -4*s - 3*p + 9 = 0, 2*p = -s - 3*s + 6. Let v(t) = 0*t + s + 0 + t - 3. Calculate v(6).
3
Let i(v) = v**2 - v - 15. Suppose 2*o + 0 = 8. Let u be o/14 + 22/(-77). What is i(u)?
-15
Suppose -6*i = -i - 40. Let c(g) be the first derivative of -g**2 + 12*g - 22. Let r be c(i). Let h(s) = s**3 + 3*s**2 - 4*s - 1. Calculate h(r).
-1
Suppose -16 = -4*s, -20 = -2*g + 4*s - 5*s. Let t(b) = 0*b**3 - 4*b + 3 - g + b**3 - 3*b**2. Suppose -h + 8 - 4 =<Global.Microsoft.VisualBasic.CompilerServices.DesignerGenerated()> _
Partial Class FormReacManager

    Inherits UserControl

    'Form overrides dispose to clean up the component list.
    <System.Diagnostics.DebuggerNonUserCode()> _
    Protected Overrides Sub Dispose(ByVal disposing As Boolean)
        Try
            If disposing AndAlso components IsNot Nothing Then
                components.Dispose()
            End If
        Finally
            MyBase.Dispose(disposing)
        End Try
    End Sub


    Me.ColumnID = New System.Windows.Forms.DataGridViewTextBoxColumn()
        Me.ToolStrip1 = New System.Windows.Forms.ToolStrip()
        Me.ToolStripDropDownButton1 = New System.Windows.Forms.ToolStripDropDownButton()
        Me.ConversaoToolStripMenuItem = New System.Windows.Forms.ToolStripMenuItem()
        Me.EquilibrioToolStripMenuItem = New System.Windows.Forms.ToolStripMenuItem()
        Me.CineticaToolStripMenuItem = New System.Windows.Forms.ToolStripMenuItem()
        Me.HeterogeneaCataliticaToolStripMenuItem = New System.Windows.Forms.ToolStripMenuItem()
        Me.ToolStripButton6 = New System.Windows.Forms.ToolStripButton()
        Me.ToolStripButton7 = New System.Windows.Forms.ToolStripButton()
        Me.ToolStripButton8 = New System.Windows.Forms.ToolStripButton()
        Me.ToolStripButton4 = New System.Windows.Forms.ToolStripButton()
        Me.ToolStripButton9 = New    double a = Convert.ToInt32(Console.ReadLine());

            Console.Write("b:");
            double b = Convert.ToInt32(Console.ReadLine());
            Console.Write("c:");
            double c = Convert.ToInt32(Console.ReadLine());
            if ((b * b - 4 * a * c) < 0) {
                Console.WriteLine("There are no real roots!");
            }


72 (95% CI : 57.8-89.3). A statistically significant excess was noted for brain cancer (SMR = 270, 95% CI : 108.6-556.9). In addition, the cohort experienced statistically significant lower lung cancer mortality (SMR = 57, 95% CI : 35.6-80.0).you use INTO within select statment and select returns no rows, you get an no data found exception. This can be handled via anonymouse begin end block with exception handler inside, but I believe this is not the case. As example:
declare
  v_value number;
begin
  select null
    into v_value
    from dual
   where 1=2;
exception
  when NO_DATA_FOUND then
    null; -- Ignore exception and continue
end;

Condition 1=2 is never met and therefore the select always returns no rows, this will always produce no data found error. With exception handler we decide what to do next. Null will do nothing in this example.
Back to your function, your condition is if variable lv_date_created is less or equal to current date


disagreements between Ecclestone and the Nurburgring’s race promoters.

The chairman of the governing motorsport body in Germany, the DMSB, has revealed on Servus TV that the race was cancelled due to a disagreement over just “two to three million euros”.

Representatives of the Eiffel region’s circuit apparently offered “a good sum”. Though Ecclestone rejected it “in his typical style”.overhead, or a cost, associated with using the relay.
As a consequence, if the relay is used at the wrong time, e.g., when the channel state of the relay-destination pair is considerably worse than the channel state of the source-destination pair, there is an observed degradation in the overall system throughput. Hence, the ability to dynamically adjust subcarrier resources allocated to an OFDMA half duplex relay node so that the relay is used only at the right time is desirable.
Conventional approaches that have sought a solution to this problem have dynamically scheduled the usage of the relay node in a centralized manner in which full knowledge of the channel states between any two nodes in the network is required. However, perfect knowledge of the channel states at various nodes


is very difficult to obtain in a distributed network. In addition, superposition coding is assumed at the source and relay node, which is not scalable as the number of nodes in the relay networks increases in terms of both the processing complexity and the signaling overhead involved in collecting all the channel state information (CSI) for the nodes. Furthermore, with such conventional approaches, the presence or absence of relays is not transparent to the source node.
Accordingly, there exists a need for improved techniques for OFDMA wireless communications systems to transmit message(s) from a source node to a destination node by scheduling resources to one or more half-duplex relay nodes in an optimal manner.facts showing that there is a genuine issue of material
                fact for trial.

Id. at 211. (emphasis in original). Where a genuine dispute exists as to any material fact or as

to the conclusions to be drawn from those facts, a court must deny a motion for summary

judgment. Id. (citing Dunn, 833 S.W.2d at 80).

        Summary judgment was improperly granted to defendant McAlpin in this case. At the

time defendant’s motion for summary judgment was granted, the record before the trial court

consisted only of the Complaint and an unsworn Answer. If the Complaint states a cause of

action, denials in the Answer without supporting affidavits cannot be the basis for


of Hamrick v. Spring City Motor Co., 708 S.W.2d 383 (Tenn.

                                                 4
1986), the Tennessee Supreme Court addressed a situation where a wrongful death action was

brought against an automobile dealer in part on a theory of negligent entrustment. Luther

Champion was allowed to take possession of a new pickup truck from the inventory of Spring

City Motor Company despite the fact that he had not yet attained a commitment from his credit

union to finance the purchase. Prior to completion of the sale, Mr.of a

driver’s license necessarily equates with driving incompetence, some jurisdictions have created

a statutory duty on the part of car dealers to investigate whether a potential customer is properly

licensed. Failure to comply is negligence per se, or at least evidence of negligence. See, e.g.,

Schneider v. Midtown Motor Co., 854 P.2d 1322 (Colo. App. 1992). The Tennessee legislature

has not seen fit to create a duty on the part of car dealers to refrain from selling vehicles to

unlicensed drivers, and we decline to attempt to judicially create such a duty. We think that the

language from Hamrick quoted above by the appellant, was not intended to create a duty to

investigate age, licensure, employment, etc., before selling a car, but was intended merely to

imply that it may be negligent to hand over the


Q:

Leading and Suffering Numbers

Introduction:
In Dutch, the words leading and suffering, being 'leiden' and 'lijden' respectively, are pronounced the same way. One is written with a "short ei", and one with a "long ij", as we Dutchman would say, but both 'ei' and 'ij' are pronounced [ɛi].
Challenge:
Given a list of numbers, determine which (if any) are leading, and which (if any) are suffering.
A leading number is:

A positive number
Has at least four digits
Is in the highest 50% of the list in terms of value
Is still in the highest 50% of the list in terms of value, if it's 3rd digit is replaced with its 2nd digit, and it's 2nd digit-position is filled with a 0 (i.e. 1234 would become 1024)

A suffering number is:

A negative number
Has at least four digits
Is inart" and Yves KLEIN "The overcoming of the problematic of art" Since the 70s, he has received a traditional training in plastic and graphic arts in Paris. The magazine "Les chroniques de l’art vivant" published from 1968 to 1975 allowed him to discover the work of young creation, at which time he carried out various experiments, including a performance in 1972 on the Champs Elysées: "universal love" for a positive awareness of humanity.

Towards an abstraction of transparencies: It is by observing the projection of the colours of stained glass windows that form ephemeral abstract images that his interest in pure light colour developed. 1980, he defined a theory on the 4 primordial colours of light and began to develop an abstract pictorial work: light and its chromatic fields


of course possess its own special gameplay mechanics. For example, the “recoilless” nature of the guns will be clearly discernible in the weakened recoil after a shot, which allows you to more accurately correct your fire through the sights. Its limited ammunition complement of 10 shells will require greater attentiveness from the player in selecting targets and aiming, but the machine guns with the same ballistics as the cannons themselves will make this task far easier. There are two types of shells available for the M40 cannons: HESH (high-explosive squash head) and HEAT (high-explosive anti-tank). The HEAT shell creates a fine directed stream of metal on a hit, penetrating the armor thanks to its huge speed. However, after the penetration, this stream can cause serious damage only toFollow KDKA-TV: Facebook | Twitter

PITTSBURGH (KDKA) – A terminally ill teenager from Pennsylvania is asking for some holiday cheer for Christmas.

Maddox Hyde, 14, is an 8th grade student at DuBois Area Middle School.

He has been receiving treatment for neuroblastoma at Children’s Hospital in Pittsburgh. He’s been battling it for eight years.

Sadly, he’s been told he only has a few weeks to live.

Now, he’s simply asking to receive Christmas cards from around the world.

Cards can be sent to the following address:

Maddox Hyde

333 Ohio Street

Reynoldsville, PA 15851

Over the last few days, he’s gotten so many, they’ve started stringing them from the ceiling at his home. Cards from churches, schools, all over the country and even from Mexico.

“It makes me feel happy to see how many people actually care,” said Maddox


housing, and into the schools.

The migrants include many illegals who sneaked across the border, as well as many Central Americans who used border-law loopholes to get temporarily released into the United States. Many of these migrants also use the joint cartel-federal “Unaccompanied Alien Child” route to bring their children up from the border.

This illegal and semi-legal population provides many new customers to local retailers, landlords, and education officials, a steady supply of replacement labor to the 2,000-person JBS slaughterhouse, and an easy opportunity for local elites to dismiss civic and economic concerns as mere bigotry. The Star Tribune reported:

“In the downtown, all the storefronts are full and it’s busy,” said Sharon Johnson, a lifelong resident who owns a downtown jewelry store and also serves as director of communitytemporary buffs – this is the kind of stuff you usually see in games like Persona 4 or BlazBlue, and seeing NetherRealms open up so many fun new doors is really refreshing. Loading

One mild distraction from the excellent combat is the visual inconsistency between characters. Some fighters, like Scorpion or newcomer D’vorah, look excellent, with tons of little details in their faces and costumes. Others, like Sonya and Jacqui, look far less detailed, with comparatively plain facial textures. It stands out because of the high peaks MKX hits during its best moments. With two of the better-looking fighters duking it out against one of the many beautiful backgrounds, this is one of the best-looking console games around, so it sticks out when everything isn’t up to the same


The LeBlanc family, avid homesteaders from North Tetagouche, N.B., have not made a trip to the grocery store in three months and don't plan on stepping inside a store for the entire winter.

While many Canadians grapple with the rising cost of groceries, the LeBlancs are completely unaffected.

"Someone told me how prices went up. We weren't really aware," said Robin LeBlanc.

LeBlanc and his wife, Rebecca, have been homesteading on their small farm near Bathurst for a decade, growing their own vegetables and trying to maintain a sustainable lifestyle.

But now they have tackled a new challenge with their three daughters under the age of eight: Melodie, Rosalie and Charlotte.

"We decided to do everything we can so we don't have to go to the grocery store," said LeBlanc.

They plan to continueCountry Liberal Party (CLP) during the previous month, leaving the CLP with a one-seat majority in the unicameral Northern Territory Parliament. After the MPs joined Palmer United, Campbell Newman, the Premier of Queensland, suggested Clive Palmer was attempting to "buy votes", which resulted in Palmer initiating defamation proceedings against Newman. The PUP is not registered with the Northern Territory Electoral Commission, but the party already meets the NTEC's eligibility requirements for registration because it is "registered under the Commonwealth Electoral Act". However, Francis Xavier resigned from the party to rejoin the CLP in September 2014, and Lee and Anderson resigned to become Independents in November.

Queensland
The United Australia Party (UAP) was registered with the Electoral Commission of Queensland (ECQ) on 5 June 2013. Alex Douglas and Carl Judge, the


EPMA of interfaces applied to the solid oxide fuel cell.
Chemical interactions at the phase boundaries of materials applied for the solid oxide fuel cell (SOFC) have been studied by EPMA. The chemical reactivity at the interface of La(y-x)Sr(x)MnO(3)/ZrO(2)-Y(2)O(3) is dependent on the stoichiometry (y) and the Sr content (x) of the perovskite. Typical reaction products (zirconates) and a diffusion zone in the ZrO(2)-Y(2)O(3) have been observed. The extension of cation release (Mn) is related to the increasing chemical activity of Mn oxide in the perovskite by the Sr substitution for La. The wettability of the metal/oxide interface in the anode cermet (Ni/ZrO(2)-Y(2)O(3)) has been found to be influenced by chemical reactions resulting from the applied reducing atmosphere with high carbon activity. The disintegration of ZrO(2)-Y(2)O(3) in contact witha different kind of requirement,” added Mr Pocock. “You need a place where you can base yourself and keep equipment and supplies and, indeed, captives. It means that you’ve got to hold territory.”

Shekau has established Boko Haram’s unofficial headquarters in the town of Gwoza in Borno state. This stronghold has been chosen with great care.

Gwoza is shielded from attack by the volcanic peaks of the Mandara Mountains spanning the nearby frontier with Cameroon. Most important of all, the surrounding area is the homeland of Shekau’s own ethnic group, the Kanuri.

From this base among his brethren, Shekau sends his fighters to strike across a vast area. The border with Cameroon means nothing to Shekau, since it slices directly through the area inhabited by the Kanuri. His men have frequently


Animal models of excessive aggression: implications for human aggression and violence.
Escalated interpersonal aggression and violence are common symptoms of multiple psychiatric disorders and represent a significant global health issue. Current therapeutic strategies are limited due to a lack of understanding about the neural and molecular mechanisms underlying the 'vicious' shift of normal adaptive aggression into violence, and the environmental triggers that cause it. Development of novel animal models that validly capture the salient features of human violent actions combined with newly emerging technologies for mapping, measuring, and manipulating neuronal activity in the brain significantly advance our understanding of the etiology, neuromolecular mechanisms, and potential therapeutic interventions of excessive aggressive behaviors in humans.by a jailor.  The note recites a version of the brothers' crime that varies substantially from James's prior statements to the authorities and from Holt's own incriminating statements.

9
The district court applied a two-level enhancement under section 3C1.1 of the Guidelines on the ground that this correspondence constituted an attempt to obstruct the administration of justice.  Holt claims this was error, arguing that the note stated the facts as he believed and continues to believe them to be.  Finding this incredible, the district court determined that the letter was written in an attempt to get James to commit perjury and manufacture testimony.

10
We review the district court's factual findings relative to sentencing enhancements for clear error.  See United States v. Gjerde, 110 F.3d 595, 604 (8th


of Justice's lawsuit against its deal with Humana did not play a part in the payer's decision to leave 11 exchanges.

"The vast majority of payers have experienced continued financial stress within their individual public exchange business," Aetna Chief Executive Officer Mark Bertolini said in the statement. "Providing affordable, high-quality healthcare options to consumers is not possible without a balanced risk pool."Poster campaign promotes 50 ideas for a new city

The project was launched and hosted by Urban Ombibus, as a way to spark conversation about how to make better cities. Space was provided so that everyone could add their own ideas.

Urban Planet is a roundup of blogs from around the world dealing specifically with urban environments. We’ll be on the lookout for websites outside the country that approach themes related to urban experiences and issues.

For more stories from around the planet, check out Spacing on Facebook and Twitter. Do you have an Urban Planet worthy article you’d like to share? Send the link to urbanplanet@spacing.ca


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a delayed response to the same noxious mechanical stimulus \[[@B51-toxins-11-00516]\] ([Table 2](#toxins-11-00516-t002){ref-type="table"}). These previous works on mycolactone suggested that mycolactone-induced hypoesthesia was attributable to nerve destruction at late stages of the disease \[[@B51-toxins-11-00516],[@B66-toxins-11-00516]\]. It was then proposed that the underlying mechanism was relevant to cytotoxity, as in leprosy \[[@B45-toxins-11-00516]\]. However, such a mechanism could not account for the analgesic effects observed at earlier stages, before the occurrence of tissue destruction. In this context, it was then natural to ask whether mycolactone could interfere with neural transmission \[[@B52-toxins-11-00516]\]. In contrast with the results of previous work \[[@B51-toxins-11-00516]\], it was shown in Marion et al. (2014) \[[@B52-toxins-11-00516]\] that mycolactone activates AT2R in neurons, with the release of phospholipase A2-mediated arachidonic acid (AA), the generation of prostaglandin E2 from AA by


protein translocation into the ER, was thus identified as a major target of mycolactone \[[@B88-toxins-11-00516]\], and its inhibition by the toxin was shown to have critical consequences on the immune system \[[@B61-toxins-11-00516]\]. It has also been proposed that the blockade of Sec61 by mycolactone could contribute to mycolactone-induced analgesia by suppressing inflammation, and further investigations are definitely needed \[[@B63-toxins-11-00516]\]. The anti-nociceptive activity of mycolactone was also demonstrated in the formalin assay in mice, which recapitulates an inflammatory context \[[@B62-toxins-11-00516]\]. The injection of formalin solution into mouse hindpaws induces two distinct periods of stereotypical licking and biting behaviors and allows discrimination between inflammatory and non-inflammatory pains. Intraperitoneal injection of mycolactone 1 h before formalin injection had no effect on the early phase (5 min), reflecting a direct effect onnociceptors (acute pain), whereas in the second phase, lasting from 10 to 40 min, an anti-nociceptive effect was observed, involving primarily inflammatory processes \[[@B62-toxins-11-00516]\] ([Table 2](#toxins-11-00516-t002){ref-type="table"}). Guénin-Macé and colleagues suggested that the inhibition of Sec61 activity by mycolactone could account for its hypoesthesic effect. Indeed, the interaction between mycolactone and Sec61 was shown to promote cell death via a reticulum endoplasmic stress response triggering cell apoptosis \[[@B56-toxins-11-00516]\] and also to lead to an impaired production of key mediators of immune responses \[[@B61-toxins-11-00516],[@B63-toxins-11-00516]\].

The effect of mycolactone on the initiation of the stress response is rapid, at within 1 h, comparable to the hypoesthesic effect of mycolactone, which is detected 2 h after mycolactone injection, arguing in favour of the involvement of such a broad-spanning pathway in the hypoesthesia \[[@B56-toxins-11-00516]\].


any Disney cartoon (except Lilo & Stitch, which is perfect unto itself, perfect, I tell you2).

Fandoms where I really can't take the source material very seriously except as a kit that fans will take apart and reassemble into something actually worth our time: Marvel Cinematic Universe. James Bond movies. Harry Potter (both novels and movies). Angel (TV series). Star Trek (all series and all movies, including reboot). Stargate SG1 and Stargate Atlantis. Star Wars (original trilogy, The Force Awakens, and Rogue One). The Losers, the Magnificent Seven remake, and other such festivals of beefcake. Supernatural. Teen Wolf. X-Men. Inception. The Hobbit and Lord of the Rings (movies).

Fandoms where the source material is barely tolerable and redeemed only by the fanworks: Leverage. Star Wars (prequels). Merlin. And please forgiveBut somehow it doesn't catch.

I think there are two things going on:

1. The source media themselves are more fanfic-savvy now, and so nothing totally loses control of its subtext the way it used to in the old days.

I can't imagine anybody making entertainment in 2016 without being aware that viewers/readers will consider the possibility that characters are attracted to one another even if you didn't write them to be attracted to one another -- even if they are [gasp] the same gender. You'd have to be living under a rock on another planet to have missed that development.

And of course to the extent that this gets us actual non-heterosexual characters that's a great thing, though that part is not moving along quite as briskly as I would like.

But


-- like, we're now getting classic Trek out of the library and watching it. And nothing equals the accidental subtext-fest that was classic Trek. I can see where the people who were slashing classic Trek could feel like they were totally stealing the archetypes and totally expressing the true nature of the show at the same time. There's nothing like that now.

2. I'm not interacting enough with fans (a situation that's unlikely to change until my nest goes empty next fall), and it's just no fun to be fannish alone.

kass asks: What do you enjoy most about parenting a kidlet of this age?

Oh, man, this age is the best. This age is ... when I think about it, it almost seems unethical. I have basically genetically engineered andat them. You remember in "Groundhog Day" the montage where the Bill Murray character just experiments with the terms of his curse? Tries things that ought to kill him, and wakes up the next morning ... learns what everybody in town is doing so that he can catch people who fall? My writing wants to be nothing but that montage.

And I'm afraid that the only way I can write meaningful conflict is to make a great slog of it. It takes forever for it to come to life and flow -- while I'm waiting for that to happen, I have to write hundreds, thousands of words that are like walking in knee-deep mud, knowing that once the life finally comes into the thing I'm going to have to


thing, would that make a decent potpie? Or is meat required?

armadillo1976 asks: Dec 4. From the perspective of a parent of a big(ish) kid, what do you remember most/best from the time your kid was 1-2? (Asking as a mom of a 1.5 year old, terrified that she is going to forget all the love and beauty and mess of these times...)

... yeah, I wish I had kept a journal, because my memories of that time are so sparse. And the photos are all prints, so they don't just come up when I'm scrolling through my phone.

I remember that the second Christmas, my brother-in-law sent the kidlet some electronic toy, and the kidlet touched it, and it sprang to life with a musical chord and a cartoonish voice */
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space more accessible.

Having more businesses take the lead, she argued, could push governments to follow suit.

“If we can show that an entire neighbourhood can get together and work together to show what accessibility looks like, then you really have some great research,” she said. “And we’ll go to our local governments and say, ‘The legislatures, the chambers, the museums, you name it, you need to do this. You need a beacon in every publicly funded building, because we’re taxpayers, too.’”

Praise for the project came from at least one industry expert, who nonetheless urged companies not to forget that true accessibility involves catering to a wide spectrum of needs beyond vision loss.

Thea Kurdi, universal design specialist with accessibility consultants DesignAble, called the CNIB’s project exciting and innovative, adding thatentire talk one hour and a half dedicated to the destruction of free speech at the University of Maryland campus, and we will send copies of that video to everybody in every alumni network we can find at the University of Maryland,” he continued, as the audience cheered and applauded. “We will send every piece of coverage we do that will shine a light on the administrators in my talk with their names, their photos, their phone numbers, and their email addresses. Of every administrator responsible.”

“You guys are sometimes powerless to fight back against bureaucracies and administrations that hold your educational future in their hands,” concluded Milo. “They have a massive Damoclean sword over your heads, because at any point they can expel you and ruin your life.


a cat who doesn't integrate in a normal human way and a single human." "I felt we need some other new person in here." "We sort of compromised by writing one as a guest star in one show called Kryten." "Well, serving makes me happy, sir." "It was a hit and Doug sort of twisted my arm and I agreed to have him back as a regular character." "But what about you?" "Don't you ever want to do anything just for yourself?" "Myself?" "Well, that's a bit of a barmy notion, if you don't mind my saying so, sir." "GRANT:" "We wanted to cast the same guy." "He was played by a guy called David Ross." "But David wasn't available for the filming." "NARRATOR:" "The human that wasgenealogical path leads you directly from Monsieur de la Tranche to me.

All of us have similarly improbable ancestors. The Vikings who pillaged Britain shared ancestors in common with today’s Khoisan of the Kalahari. The young black boy in the African Ancestry ad has ancestors who were peasants in Roman Gaul. The branches of all our family trees eventually tangle.

Yet genealogies as we imagine them tell us something like the opposite. They confirm our fantasies of tribal identity, promising a relation to particular individuals who have somehow bestowed upon us through the ages the attributes which set us apart from others. These imagined clans have little basis in reality, and like the mythic genealogies once drawn for ancient kings, they are not intended to accurately represent history. To the


Near Field Communication (NFC) a short-range wireless connectivity technology having various standards such as Ecma-340 and ISO/IEC 18092. NFC technology uses magnetic field induction to enable communication between devices that are either touched together, or brought within a few centimeters of each other. NFC technology may be integrated with various devices such as mobile phones. Various applications, for example a credit card, may be securely provisioned to an NFC enabled mobile phone such that customers can pay for goods or services by simply waving their mobile phone at a point-of-sale reader. One of the many uses cases for NFC is to enable transit applications. In a transit application use case, a subscriber would utilize their mobile phones to board metro trains, buses, trams or other modes of transport.
AThe invention relates generally to articles comprising thermal barrier coatings. More particularly, the invention relates to articles comprising thermal barrier coatings having a thermal barrier material and a calcium-magnesium-aluminum-silicon-oxide (CMAS)-reactive material.
Thermal barrier coatings are typically used in articles that are exposed to high temperatures. Aviation turbines and land-based turbines, for example, may include one or more components protected by the thermal barrier coatings. Under normal conditions of operation, thermal-barrier coated components may be susceptible to various types of damage, including erosion, oxidation, and attack from environmental contaminants.
For turbine components, environmental contaminant compositions of particular concern are those containing oxides of calcium, magnesium, aluminum, silicon, and mixtures thereof. These oxides combine to form contaminant compositions comprising mixed calcium-magnesium-aluminum-silicon-oxide systems (Ca—Mg—Al—SiO), hereafter referred to as “CMAS.” At the high turbine


one another using infrared signals as players’ iPhones connect over Bluetooth, letting friends battle against each other or participate in arcade and cooperative gameplay.With the built-in augmented reality support, gamers can choose to play with their MekaMon robots either in the real world or using augmented reality. Once a battle is engaged, MekaMon is able to move and use objects in the room like tables, chairs, and more to block attackers.Each MekaMon robot can be customized by adding weapons or shields to make the robot more aggressive, defensive, or technically inclined, and the MekaMon robots are compatible with Swift Playgrounds, so users can control their robots using Swift code.MekaMon can be used as a code learning tool with users able to implement “fundamental coding concepts” to control MekaMon’sCHICAGO (Reuters) - A total of 101 people were shot in Chicago over an unusually violent Fourth of July weekend, leaving at least 14 dead, according to police and local media, as the city continues to grapple with gun crime.

FILE PHOTO: Some of the guns seized over the last week are seen on display at the Chicago Police Department in Chicago, Illinois, United States, August 31, 2015. REUTERS/Jim Young/File Photo

Police officials counted 71 shooting incidents and 14 murders between 6 p.m. CDT on Friday and early Wednesday, according to data provided by police spokesman Frank Giancamilli on Wednesday.

The Chicago Tribune newspaper tallied the total number of victims shot in those incidents at 101 between Friday afternoon and early Wednesday. Police could not immediately provide the number of victims


a unique mechanism for coenzyme B6 catalysis. Study of cyclopropane fatty acid (CFA) synthase, started in the current grant period, represents our first foray into the biosynthesis of three membered ring compounds. This mechanistically intriguing enzyme is a potential target for developing treatment of drug-resistant bacterial infections. To explore the construction of three-membered ring systems other than carbocycles, we have recently initiated a study of oxiranyl ring formation catalyzed by (S)-2-hydroxypropylphosphonate (HPP) epoxidase in the biosynthesis of antibiotic fosfomycin. This epoxidation is unusual since it is effectively a dehydrogenation reaction of a secondary alcohol. This enzyme holds potential to be used to prepare bioactive agents containing a reactive oxirane group. Outlined in this proposal are our future plans to further characterize the reactions catalyzed by CFA synthase andor Naples yellow, burnt sienna and sap green. Feel free to experiment as that is what we are doing today!

Temporary palette or white ceramic plate you can wash when you are done. *Only put out a small amount of paint because we will be contaminating it with salt, that’s why I recommend you work fresh from the tube. (BTW by temporary I DO NOT mean disposible, I mean one you do not leave/store your paint permanently in.)

I suggest having one bucket of fresh water (for cleaning your brush) and one bucket of salt water for wetting the paper and mixing on your palette. You can dissolve 2 tablespoons of salt in a cup of water at room temperature so I’m going to try that. I might need to


           2.64 (2.37-2.94)                                         \<0.001

Odds ratios were constructed for hospital mortality with univariate/multivariate analysis. ^a^SAPS II, Simplified Acute Physiology Score II; ^b^NYHA, New York Heart Association functional classification.

######

Cardiac arrest treatment frequency strata and patients baseline characteristics

                      mortality was 66%. Risk-adjusted mortality was 0.851 (0.836 to 0.865) for cardiac-arrest patients.

Table [3](#T3){ref-type="table"} shows the measures of intensive care as reflected by the TISS-28 score for each of the three strata of ICUs grouped by cardiac-arrest frequency. In high-frequency cardiac arrest ICUs, enteral nutrition was favored over parenteral nutrition. Renal support was initiated in fewer patients in ICUs with high case loads of postresuscitation patients. Patients received fewer diuretics in high-frequency ICUs. A combination of vasopressor medications was applied in fewer patients in ICUs with a high frequency of postresuscitation care. A peripheral artery catheter was used in more patients in high-frequency ICUs.

######

**Interventions as measured by TISS-28**^**a**^**score parameters by frequency of postresuscitation care in the ICU**


How microorganisms tip the balance between interleukin-12 family members.
Interleukin-12p70 (IL-12p70) induces T-helper-1-cell responses and IL-23, a related cytokine, is the master switch in several T-cell-mediated inflammatory disorders. IL-27, another member of the IL-12 family, regulates innate and adaptive immune responses. Recently, distinct combinations of transcription factors have been shown to regulate the expression of the genes that encode these three cytokines. Toll-like receptor ligands, in association with other microbial products and endogenous mediators, tip the balance between the expression of IL-12 family members and thereby may control the outcome of T-cell-mediated inflammation. On this basis, we present a novel perspective on the pathogenesis and regulation of inflammatory disorders.FTY720-Mitoxy reduces synucleinopathy and neuroinflammation, restores behavior and mitochondria function, and increases GDNF expression in Multiple System Atrophy mouse models.
Multiple system atrophy (MSA) is a fatal disorder with no effective treatment. MSA pathology is characterized by α-synuclein (aSyn) accumulation in oligodendrocytes, the myelinating glial cells of the central nervous system (CNS). aSyn accumulation in oligodendrocytes forms the pathognomonic glial cytoplasmic inclusions (GCIs) of MSA. MSA aSyn pathology is also associated with motor and autonomic dysfunction, including an impaired ability to sweat. MSA patients have abnormal CNS expression of glial-cell-line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF). Our prior studies using the parent compound FTY720, a food and drug administration (FDA) approved immunosuppressive for multiple sclerosis, reveal that FTY720 protects parkinsonian mice by increasing BDNF. Our FTY720-derivative, FTY720-Mitoxy,


same method name (e.g., a "motion" method), then some changes can be made to the model. If, however, the programmer does not want to replace the behavior simulated by the general algorithm but wants to add the soil motion algorithm so that the effects of differing soil can be controlled simultaneously and independently, then such changes are more difficult because the new method (not previously declared) cannot be added easily in a static environment.
The present invention is described below using some object-oriented techniques; thus, an overview of well-known object-oriented programming techniques is provided. Two common characteristics of object-oriented programming languages are support for data encapsulation and data type inheritance. Data encapsulation refers to the binding of functions and data. Inheritance refers to the ability to declare a dataA derived class is a class that inherits the characteristics--data members and function members--of its base classes. A class that inherits the characteristics of another class is a derived class. A class that does not inherit the characteristics of another class is a primary (root) class. A class whose characteristics are inherited by another class is a base class. A derived class may inherit the characteristics of several classes; that is, a derived class may have several base classes. This is referred to as multiple inheritance.
A class may also specify whether its function members are virtual. Declaring that a function member is virtual means that the function can be overridden by a function of the same name and type in a derived class. If a virtual function is


Monday, 12 September 2011

Millie Monday

Hihihihihihihi! Hi, hi, hi! I don't really know who I'm sayin hi to, cuz I can't see nobody, and the talky thing that my mummycat says is called Computer doesn't look like a nobody neither cuz nobodies aren't square and they don't have leads coming from them and they don't not move. Nobodies, ah, scuse me, my mummycat says they're somebodies, not nobodies, are warm and they move and if they're mummycats then they talk to you and clean you and sometimes give you milk and smack you when you're bad (I don't like that bit). And if they're people somebodies then they make strange noises at you and you can climb on the flat places they call shoulders and you can attack theirI love my crinkle balls that mummycat says were hers from another somebody called Amy and her cats. Are all cats mummycats? I don't know. But anyway, I chase them everywhere, and I steal pipe cleaners and carry them in my mouth, and I sometimes hide them in the litter tray, but then the human spoils the game and throws them away cuz she says they're dirty but I don't think so. I'm learning to jump real high too. I jump right up in the air to catch the flying feathers that sometimes come out when the human is around, and I jump on people somebodies when I want them to pick me up so that I can get on their shoulders. The other morning, I jumped so


in real close against her neck and thinked that I could stop the bed thing from making her eated all up. And then it musta worked, cuz she stopped making the sleep noises and she moved and then the bed thing sicked up one of her arms cuz it wriggled out from under and came and tickled my tummy and then she said that I was real cute and that she loved me lots. She told me she's always wanted a cat to come sleep all snuggly with her, and that made me feel good. But then the bed eated her arm again and the sleep noises came back, so I stayed on her pillow and when she moved I moved too and snuggled in real, real tight,as tight as I could. And I didn't even attack her hair or anything!

The bed thing sicked all of her up when the bright thing in the sky called a sun came out from hiding, and that was good, and I was happy. So I climbed onto her shoulder thing and helped her make my breakfast which I eated lots of cuz she says I need to eat more so that I get big and strong like my brothers. I don't need to be though. When you're small, you can bite their bums and run away before they know it was you. Hahahahaha! Woops, mummycat heard me say that. Gotta go!

Human note: The Katnip mommy will put some pictures of little Millie up for me soon, I think,


override UseResourceOne(ISpecificResourceOne one)
    {
        DoStuff((ResourceOne)one);
    }
}

As can be seen, I am essentially trying to have two inheritance chains on the same object, but of course I can't do this so I simulate the second version with interfaces.
The thing is though, I don't like using interfaces for this; it seems wrong, in my mind an interface defines a contract, any class that implements that interface should be able to be used where that interface is used but here that is clearly not the case because the interfaces are being used to allow an object from the layer to masquerade as something else, without the application needing to have access to its definition.
What technique would allow meIllinois residents who have been prescribed opioids will now be eligible for a temporary certification for medical cannabis. The Opioid Alternative Pilot Program was approved via the Alternative to Opioids Act by lawmakers last year by a sweeping 44-6 majority in the state senate, but lagged in implementation due to “a heavy IT lift” required to get the new system’s tech needs met.

“We’ve got to do everything we can to stop this vicious epidemic,” said Governor Bruce Rauner upon signing the bill into effect back in August. “We are creating an alternative to opioid addiction … It’s clear that medical marijuana treats pain effectively, and is less addictive and disruptive than opioids.”

The Act was sponsored by Illinois Senator Don Harmon and Representative Kelly Cassidy. At the time of


divided into groups with high (High-Fit) and low (Low-Fit) levels of cardiorespiratory fitness based on the median value of V̇O(2peak) for sex and decade. Levels of body fat, triglycerides, and plasma glucose were lower and high-density lipoprotein cholesterol levels and V̇O(2peak) were higher in High-Fit subjects than Low-Fit subjects. ADRB3 Trp64Arg polymorphism did not significantly affect ccIMT or blood lipid profiles. In Low-Fit subjects, ccIMT was higher in individuals with the Arg/Arg genotype compared to the Trp/Trp and Trp/Arg genotypes (each P < 0.0001); however, ADRB3 polymorphism had no effect in High-Fit subjects. Higher levels of cardiorespiratory fitness may attenuate the risk of atherosclerosis associated with ADRB3 Trp64Arg polymorphism.cancel his place instead. This would remove his worries about it in one fell swoop. Presumably he still wants to go, and maybe he'll stop hassling you for confirmation you're unable to give if the alternative is that he doesn't go at all. Don't waste your time trying to get his mate in, you've enough on your plate already.

As you have apologised for what you said already, I'm not really sure whether you should apologise again, but it might help. That's up to you.

I do think he should look at his own behaviour. When things have calmed down, you could ask him why he was goading you. You'll have to do it very non-confrontationally though.

I think you'll be lucky to get him to admit any wrong-doing while he


theatrical the music is, the more I get into it. I also like the quieter folk music, that kind of old-school rockabilly or country. I'm not really picky when it comes to music, as long as it's honest."Author: Landon Liboiron

24. "The manager frowned, as if the middle Baudelaire had given him the wrong answer.That's the rooftop bathing salon," he said. "People who sunbathe aren't usually interested in library science, so they're not picky about the salon's location. Now get moving!"Author: Lemony Snicket

25. "At work, we have fantastic catering people. They feed the cast and crew all day, and they're sensitive to the needs of picky vegetarians like me. They have delicious salads. I keep mine simple: romaine lettuce, avocado, baked tofu, carrots, tomatoes and Asian dressing."Author: Lisa Edelstein

26.Texas in this multi-state settlement with TCF Leasing.

Arizona consumers holding a NorVergence telecommunications contract are encouraged to file a complaint with the Arizona Attorney General’s Office. Consumers can visit the Attorney General’s Web site at www.azag.gov to complete an online complaint.