$B_{L-1}$ as in by a squared Frobenius term. The sub-problem is a non-negative least squares for which specialized methods exist [@kim2014algorithms].

For a cross-entropy loss and when the second-to-last layer is a ReLU activation, the sub-problem for the last layer takes the convex form $$\begin{aligned}
    X_L^+ = &\arg\min_{Z \ge 0} -\operatorname{Tr}Y^\top \log s(W_LZ) +\notag\\&\dfrac{\lambda}{2} ||Z - X_{L-1}^0||^2_F ,\end{aligned}$$ where $s(\cdot): \mathbb{R}^n \rightarrow \mathbb{R}^n$ is the softmax function and $\log$ is the element-wise logarithm. @askari2018 show how to solve the above problem using bisection.

### Updating $W$-variables

With fixed $X$-variables, the problem of updating the $W$-variables can be solved in parallel across layers and data points.

#### Sub-problems for non-batched model.

The problem of updating $W_l$ at intermediate layers becomes $$\begin{aligned}
 \label{fullwbsubproblem}
    W_l = \arg\min_{W,} & \: \lambdaThe matter was brought before the council at the behest of Theresa De Nova, the township’s health officer, whose office has been inundated with complaints regarding the number of feral and stray cats roaming through neighborhoods. Though both feral and stray cats are homeless felines, there is a significant difference between the two: Stray cats are socialized to people while feral cats are not. Under the new ordinance, residents are not allowed to feed either kind.

Ms. DeNova can now threaten cat feeders with court and fines, which she seems very excited about. Most residents do not share her enthusiasm:

But the majority of people in attendance were opposed to the ordinance, at times calling out their opinions from the benches and loudly applauding like-minded speakers. Their opinion was clear:


antifreeze. I found a pie plate underneath that home over there with antifreeze in it. And between the well house and the water tank, I found a cat food can with antifreeze in it,” White said.

In fact, the KSPR news crew saw evidence of what may be a crime during its visit to the park:

On Thursday, KSPR found the charred remains of one cat that had been burned in a pile of debris. An investigator with the Humane Society of Missouri, along with deputies from the Stone County Sheriff’s Department were also present. An investigation is underway.

Mr. Rich would only speak briefly by phone with the KSPR reporter before hanging up. He denied writing the notice received by residents and said he would allow the park’s cats and  "name" : "UseImageDirection",
      "type" : "bool",
      "default" : "false",
      "briefdescriptionSet" : "",
      "detaileddescriptionSet" : "The UseImageDirection flag determines whether image derivatives are computed with respect to the image grid or with respect to the physical space. When this flag is ON the derivatives are computed with respect to the coordinate system of physical space. The difference is whether we take into account the image Direction or not. The flag ON will take into account the image direction and will result in an extra matrix multiplication compared to the amount of computation performed when the flag is OFF. The default value of this flag is On.",


went through going to the Finals with him but then also had to deal with him leaving and continuing to try and figure it out without him. Even with that, the fans still sold that place out. We lost like 20 games in a row that year but the fans were still there for every game. So I’m just happy for Bron and that city, they deserve it. I’m excited for this weekend and I’m just going to be spending time with the fans. I’m not even really concerned about the game. I want to get out there with the people and let them know how much I appreciate the love they gave me while I was there. So when you look at the history and what he’sis being brought out to the center of attention.

Don’t think that it is all a coincidence. It is clearly designed this way. Like the enormous flood of free pornography did not come from out of the blue. The hidden message is clear: watch as much free porn as you can in your free time, watch football, enjoy booze, and put your sexual identity at the very center of your existence.

Then, define all those who disagree with these sorts of lifestyles as ‘intolerant’, ‘backward’, and even ‘oppressive’.

Why is all this happening? Why are Western countries so obsessed with “sexual identities”?

The answer is simple: because those who are obsessed with their own bodies, desires, identities and endless “rights”, have hardly any time left to think about the rest of the


obviously a much more important topic in the UK and the US, than whether Western imperialism should be stopped, once and forever.

But remember: We will all burn if we burn. Heterosexuals, homosexuals, trans-gender individuals, even those whose sexual orientation I still do not understand. If there is a Third World War, we will all be fried.

Therefore, I suggest that we first try to disarm the Empire, stop savage capitalism, give freedom and the right to choose their destiny to all nations of the world, and then… Only then, shall we make sure that we support all the people of countless sexual orientation, that our humanity has.

But first things first, please!

Unfortunately, the majority of people do not have the capacity to fight on various fronts, for numerous causes. Andgoes, his Tweet was a perfect formulation of the corrupted liberal mind.
____________“The only end of writing is to enable the reader better to enjoy life, or better to endure it.”
–Samuel Johnson

Warner Todd Huston is a Chicago based freelance writer. He has been writing news, opinion editorials and social criticism since early 2001 and before that wrote articles on U.S. history for several American history magazines. Huston is a featured writer for Andrew Breitbart’s Breitbart News, and he appears on such sites as RightWingNews.com, CanadaFreePress.com, Wizbang.com, and many, many others. Huston has also appeared on Fox News, Fox Business Network, CNN, and many local TV shows as well as numerous talk radio shows throughout the country.

NOTE: If you want to comment, for some reason our Facebook comments section takes


magazine syringe bodies projecting during filling. In the case of glass syringes, a certain breakage damage and the danger of sliding of the finger during the application process exists, which was found by patients to be very unpleasant.
In accordance with a second concept from the which the present invention is derived, the gripping strip is formed as a separate synthetic plastic part and subsequently, or in other words after the filling process, is mounted on the syringe cylinder which can be composed of glass or synthetic plastic. With this concept the disadvantages of the first concept with the one-piece formed gripping strip can be eliminated.
Since the gripping strip must withstand high pulling out forces, the strength or stability of the connection of the synthetic plastic gripping strip withCadbury is facing the prospect of a black consumer boycott after it compared Naomi Campbell to a chocolate bar in a new advertising campaign.

The supermodel – hardly known for taking things in her stride – is incensed that Cadbury used her name in the strap line to promote its new chocolate bar called Bliss, accusing the company of racism. The ad says: "Move over Naomi – there is a new diva in town."

Yesterday Campbell revealed she is considering "every option available" after Cadbury, owned by the US giant Kraft, refused to pull the ad campaign, which ran in newspapers last week: "I am shocked. It's upsetting to be described as chocolate, not just for me, but for all black women and black people. I do not find any


or in any industry or activity affecting commerce; or (2) by any employee organization or organizations representing employers engaged in commerce or in any industry or activity affecting commerce; or (3) by both." 29 U.S.C. § 1003(a). One type of "employee benefit plan" that can come under ERISA is an employee welfare benefit plan, which is defined by ERISA as "any plan, fund or program ... established or maintained by an employer or by an employee organization, or by both, for the purpose of providing its participants or their beneficiaries, through the purchase of insurance or otherwise [certain benefits, including medical, surgical or hospital care or benefits]." 29 U.S.C. § 1002(1). ERISA defines "employer" as "any person acting directly as an employer, or indirectly in the interest ofplan and that each acted as plan sponsor of its individual plan. Moreover, they no longer claim that the franchisees acted directly as employers but instead assert that they acted indirectly in the interest of their clients, who were the actual, direct employers. In the court's opinion, regardless of which position the franchisees wish to maintain, their arguments are without merit.

(A) Did Jobmate of Mississippi establish and maintain an employee welfare benefit plan?
In MDPhysicians & Associates v. State Board of Insurance, 957 F.2d 178 (5th Cir.1992), the Fifth Circuit explained that while some MEWA's are employee welfare benefit plans, others are not. Those that are not do not qualify as ERISA plans and hence are not governed by ERISA. See id. 957 F.2d at 181 ("Only MEWAs that


its clients' employees, yet the Fifth Circuit obviously did not consider this a sufficient "representational link" to deem MDP a statutory employer under ERISA; MDP's "primary interest" was not in protecting the interests of its clients' employees, but rather was "in profiting from the provision of medical and administrative services." Id. at 185. Here, too, the franchisees' "primary interest" was in profiting from the provision of their package of services and benefits to subscribing employers. That the employees, as the recipients of the insurance coverage, may have received some incidental benefit from the franchisees' efforts does not mean that the franchisees were acting in the interest of the employers, as contemplated by ERISA. In summary, therefore, in the case at bar, as in MDPhysicians, there was no relationshipeither corporation. According to the second paragraph the title and the situs of such title, to the equipment involved, was in Marion County and was not in Putnam County. Also it averred that the equipment was not in Putnam County on March 7, 1963. All material facts were denied by appellant.
Appellant says the only question involved is whether the venue of an action to foreclose a mechanic's lien on equipment is in the county where the equipment is located. Appellees contend there is also involved additional questions of abatement because there were two actions pending at the same time, and also a question of fact as to whether the equipment was actually in Putnam County when the action commenced.
In connection with the pendency of two actions, appellant insists


cognizance of the owner but determines the right in specific property against all of the world, equally binding on everyone.
1 Am.Jur.2d, Actions, § 40.
The General Assembly intended the plain meaning of its words when it used the phrase "... the county where such.... equipment ... is located."
As to the fact, raised by appellees, that no relief was sought from Broadstreet, we consider this of no concern in an action in rem. Where he is alleged to be in possession of the item involved in an action in rem he is a proper party.
We hold that venue of the action was in the county where the equipment was located when the action was commenced.
This brings us to the question of whether the evidence or inferences therefrom support the findinga company with onerous regulations before Nesbitt’s company would then “grab” the business for pennies on the dollar New eye-opening revelations about George Soros, Tom Steyer, Penny Pritzker, Dick Durbin, Jared Kushner, and myriad other members of the Washington elite

The author’s past investigative books have led to federal investigations, congressional resignations, or the launch of Capitol Hill ethics probes.

Schweizer’s 2015 book, Clinton Cash, broke the Uranium One scandal and sparked an FBI investigation into the Clinton Foundation.

In 2013, Schweizer released Extortion: How Politicians Extract Your Money, Buy Votes, and Line Their Own Pockets. CBS News’s 60 Minutes covered the book, which sparked the resignation of Rep. Rob Andrews (D-NJ).

In 2012, 60 Minutes covered Schweizer’s book Throw Them All Out, which uncovered insider trading by members of Congress and


You should have received a copy of the GNU General Public License
    along with this program.  If not, see <http://www.gnu.org/licenses/>.
******************************************************************************/

#include <stdlib.h>
#include <stdio.h>
#include <unistd.h>
#if defined(__FreeBSD__)
#include <sys/sysctl.h>
#endif
#include <sys/sysinfo.h>
#include <sys/utsname.h>
#include <xcb/xcb.h>
#include <X11/Xlib.h>
#include <X11/Xutil.h>
#include <X11/Xlib-xcb.h>
#include <X11/keysym.h>
#include <inttypes.h>
#include "util/dstr.h"
#include "obs-internal.h"

const char *get_module_extension(void)
{
	return ".so";
}

#ifdef __LP64__
#define BIT_STRING "64bit"
#else
#define BIT_STRING "32bit"
#endif

static const char *module_bin[] = {
	"../../obs-plugins/" BIT_STRING,
	OBS_INSTALL_PREFIX "/" OBS_PLUGIN_DESTINATION
};

static const char *module_data[] = {
	OBS_DATA_PATH "/obs-plugins/%module%",
	OBS_INSTALL_DATA_PATH "/obs-plugins/%module%",
};

static const int module_patterns_size =
	sizeof(module_bin)/sizeof(module_bin[0]);

void add_default_module_paths(void)
{
	for (int i = 0; i < module_patterns_size; i++)
		obs_add_module_path(module_bin[i], module_data[i]);
}

/*
 *   /usr/local/share/libobs
 *   /usr/share/libobs
 */
char *find_libobs_data_file(const char *file)
{
	struct dstr output;
		dstr_init(&output);

	if (check_path(file, OBS_DATA_PATH "/libobs/", &output))
		return output.array;

	if (OBS_INSTALL_PREFIX [0] != 0) {
		if (check_path(file, OBS_INSTALL_DATA_PATH "/libobs/",
					&output))
			return output.array;
	}

	dstr_free(&output);
	return NULL;
}

static void log_processor_cores(void)
{
	blog(LOG_INFO, "Processor: %lu logical cores",
	     sysconf(_SC_NPROCESSORS_ONLN));
}

#if defined(__linux__)
static void log_processor_info(void)
{
	FILE *fp;
	int physical_id = -1;
	int last_physical_id = -1;
	char *line =XK_KP_6;
	case OBS_KEY_NUM7: return XK_KP_7;
	case OBS_KEY_NUM8: return XK_KP_8;
	case OBS_KEY_NUM9: return XK_KP_9;
	case OBS_KEY_COLON: return XK_colon;
	case OBS_KEY_SEMICOLON: return XK_semicolon;
	case OBS_KEY_LESS: return XK_less;
	case OBS_KEY_EQUAL: return XK_equal;
	case OBS_KEY_GREATER: return XK_greater;
	case OBS_KEY_QUESTION: return XK_question;
	case OBS_KEY_AT: return XK_at;
	case OBS_KEY_A: return XK_A;
	case OBS_KEY_B: return XK_B;
	case OBS_KEY_C: return XK_C;
	case OBS_KEY_D: return XK_D;
	case OBS_KEY_E: return XK_E;
	case OBS_KEY_F: return XK_F;
	case OBS_KEY_G: return XK_G;
	case OBS_KEY_H: return XK_H;
	case OBS_KEY_I: return XK_I;
	case OBS_KEY_J: return XK_J;
	case OBS_KEY_K: return XK_K;
	case OBS_KEY_L: return XK_L;
	case OBS_KEY_M: return XK_M;
	case OBS_KEY_N: return XK_N;
	case OBS_KEY_O: return XK_O;
	case OBS_KEY_P: return XK_P;
	case OBS_KEY_Q: return XK_Q;
	case OBS_KEY_R: return XK_R;
	case OBS_KEY_S: return XK_S;
	case OBS_KEY_T: return XK_T;
	case OBS_KEY_U: return XK_U;
	case OBS_KEY_V: return XK_V;
	case OBS_KEY_W: return XK_W;
	case OBS_KEY_X: return XK_X;
	case OBS_KEY_Y: return XK_Y;
	case OBS_KEY_Z: return XK_Z;
	case OBS_KEY_BRACKETLEFT: return XK_bracketleft;
	case OBS_KEY_BACKSLASH: return XK_backslash;
	case OBS_KEY_BRACKETRIGHT: return XK_bracketright;
	case OBS_KEY_ASCIICIRCUM: return XK_asciicircum;
	case OBS_KEY_UNDERSCORE: return XK_underscore;
	case OBS_KEY_QUOTELEFT: return XK_quoteleft;
	case OBS_KEY_BRACELEFT:


OBS_KEY_NUM0 && key <= OBS_KEY_NUM9) {
		if (obs->hotkeys.translations[key]) {
			dstr_copy(dstr, obs->hotkeys.translations[key]);
		} else {
			dstr_printf(dstr, "Numpad %d",
					(int)(key - OBS_KEY_NUM0));
		}
		return;
	}

#define translate_key(key, def) \
	dstr_copy(dstr, obs_get_hotkey_translation(key, def))

	switch (key) {
	case OBS_KEY_INSERT:       return translate_key(key, "Insert");
	case OBS_KEY_DELETE:       return translate_key(key, "Delete");
	case OBS_KEY_HOME:         return translate_key(key, "Home");
	case OBS_KEY_END:          return translate_key(key, "End");
	case OBS_KEY_PAGEUP:       return translate_key(key, "Page Up");
	case OBS_KEY_PAGEDOWN:     return translate_key(key, "Page Down");
	case OBS_KEY_NUMLOCK:      return translate_key(key, "Num Lock");
	case OBS_KEY_SCROLLLOCK:   return translate_key(key, "Scroll Lock");
	case OBS_KEY_CAPSLOCK:     return translate_key(key, "Caps Lock");
	case OBS_KEY_BACKSPACE:    return translate_key(key, "Backspace");
	case OBS_KEY_TAB:       = codec.Id;
      numInStreams = codec.NumInStreams;
      numOutStreams = 1;
      return true;
    }
  }
  #ifdef EXTERNAL_CODECS
  if (externalCodecs)
    for (i = 0; i < (UInt32)externalCodecs->Size(); i++)
    {
      const CCodecInfoEx &codec = (*externalCodecs)[i];
      if (codec.Name.CompareNoCase(name) == 0)
      {
        methodId = codec.Id;
        numInStreams = codec.NumInStreams;
        numOutStreams = codec.NumOutStreams;
        return true;
      }
    }
  #endif


State Council of Defense established pursuant to Chapter 990 of the Public Laws of 1941, “An Act Relating to National and State Defense, Providing for the Establishment of a State Council of Defense and of Local and District Councils of Defense, and Prescribing the Powers and Duties Thereof” approved April 16, 1941. Council consisted of eleven members appointed by and serving at the pleasure of the Governor. Members chosen with reference to special knowledge of industry, agriculture, consumer protection, labor, education, health, welfare or other subjects relating to national or state defense. Governor designated as Chairman.

State Emergency Defense Act established by Chapter 1150 of the Public Laws of 1942 entitled “An act Conferring Upon the Governor and the Sate Council of Defense Emergency Powers, the Better to enableVisit www.attractlovenowseries.com to view a 2 minute video & sign up this FREE ONLINE series of 30 minute AUDIO interviews with 21+ leading LOVE experts. The series launch is Feb. 4th for 21 days you can listen to leading love expert give you their latest strategies and insights into self-love, dating and relationships!

SCOTTSDALE, Ariz. - Jan. 31, 2019 - Amzeal -- We are excited to announce the FREE ONLINE Attract Love Now Series: Unlock the confidence and self-love within to create an extraordinary relationship! Airing February 4th-24th 2019

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This 21 days FREE ONLINE SERIES is perfect for women who have experienced frustrations, break-ups and heartbreaks in the dating and relationship world!James Cullingham

James Cullingham Ph.D (born March 5, 1954) is an award winning documentary filmmaker, historian and journalist. He is currently an instructor at the Chanie Wenjack School for Indigenous Studies at Trent University. in Nogojiwanong - Peterborough Ontario, Canada. He will be Visiting Fellow at Trent’s Peter Gzowski College in winter term 2020. He was a professor of Journalism and English and Liberal Studies at Seneca College (Seneca@York) in Toronto from 2002 - 2018. Cullingham was coordinator of the Journalism programme at Seneca  2004 - 2011.

Cullingham has also served as an executive producer with the Canadian Broadcasting Corporation (CBC). In 1989 he formed Tamarack Productions to produce Canada's first national documentary series on Aboriginal issues featuring the work of Indigenous and non Indigenous filmmakers.  Since then


Mouni Roy – Confirms Gold in Cryptic Style

Actress Mouni Roy is making her big Bollywood debut with Excel Entertainment’s forthcoming film “Gold” and actress confirms the news in a very cryptic manner on the sidelines of media event here in Mumbai.
Mouni Roy is all set to explore the silver-screen opposite Akshay Kumar in upcoming movie “Gold” – which has already gone on floors. When asked about working on the film, the actress gave a cryptic confirmation.
She said, “Let me put it this way, I’m doing one part in one film. So far, I’ve shot very little but I think it’s always a process and it is new for me, so I am learning so much. I am really grateful for the opportunity”
Mouni Roy is a Bengali Indian television
283 S.E.2d 836 (1981)
STATE of West Virginia
v.
Nathan VAN ISLER.
No. 14931.
Supreme Court of Appeals of West Virginia.
November 3, 1981.
Fitzsimmons & Parsons and Robert P. Fitzsimmons, Wheeling, Gold & Khourney and David R. Gold, Moundsville, for appellant.
Chauncey H. Browning, Jr., Atty. Gen., and Timothy Huffman, Asst. Atty. Gen., Charleston, for appellee.
McHUGH, Justice:
This is an appeal from a final order of the Circuit Court of Ohio County, entered on December 10, 1979, which sentenced the appellant, Nathan Van Isler, to serve one to 15 years in the West Virginia Penitentiary for the crime of breaking and entering a dwelling house. The appellant assigns the trial court's admission of fingerprints taken *837 when he was a juvenile, and testimony based thereon, into evidence at his trial as error.
The record discloses that the


typically uses fraction of cells affected (*f*~*a*~), a number between zero and one defined based on relative viability or net growth rate inhibition normalized to an untreated control at a fixed timepoint, as drug effect \[[@pcbi.1007688.ref003],[@pcbi.1007688.ref007]\]. We argue that this commonly used approach leads to a bias in the estimation of both drug efficacy and combination effectiveness in heterogeneous cell populations, especially when the ultimate goal is to block or eradicate small subpopulations of drug-tolerant cells. This is because *f*~*a*~ quantities are not equal to the time-dependent probabilities at which cell death or inhibition of cell division are induced by a drug.

In this paper, we discuss evaluating time-dependent drug responses based on probabilistic metrics that quantify drug-induced tumor cell killing and inhibition of division at a single-cell level.derivation details): $$P_{stasis} = 1 - \frac{P_{division(with\mspace{720mu} drug)}}{P_{division({no\mspace{720mu} drug})}} = 1 - \frac{k_{division(with\mspace{720mu} drug)}}{k_{division({no\mspace{720mu} drug})}}$$ $$k_{stasis} = {P_{stasis}k}_{division(no\mspace{720mu} drug)}$$

The model provides a framework to simulate how dose-dependent responses in populations of cells vary with *P*~*death*~ per unit of time (h) and *P*~*stasis*~ by using input parameters (*k*~*death*~ and *k*~*stasis*~) that represent drugs with a wide range of cytotoxic and cytostatic effects. For each condition, the fraction of cells affected (*f*~*a*~), defined based on changes in relative viability or net growth rate inhibition (using recently developed drug-induced proliferation (DIP) and growth rate (GR) inhibition metrics \[[@pcbi.1007688.ref005],[@pcbi.1007688.ref006]\]) normalized to an untreated control, are also derived as model outputs ([Fig 1B and 1C](#pcbi.1007688.g001){ref-type="fig"}). We compared *f*~*a*~ quantities with probabilistic measures of drug action (*P*~*death*~ and *P*~*stasis*~) across a number of drug


that is when cells reached confluency under these conditions. Data are shown as mean ± SEM across four replicates. **(C)** Single-cell profiles of COLO858 response to Vemurafenib depicted based on manual tracking of individual cells exposed to different concentrations of Vemurafenib as described in (A). Each cell track is presented horizontally along time axis. Division events are marked as red circles. Transition from white to black represents a cell death event. Times at which cells spend out of field of view are shown in light green. **(D)** Single-cell profiles of COLO858 response to Vemurafenib simulated based on *Poisson* processes using rate parameters estimated from COLO858 experimental data along 12 h time intervals. **(E)** Comparison of normalized distributions of division and death events along 12 h time intervals betweenBliss independence model. Despite its probabilistic definition, however, the Bliss model is broadly applied to a variety of *f*~*a*~ metrics (such as normalized viability or net growth rate inhibition), thereby leading to unreliable conclusions which are largely due to the following limitations. First, although *f*~*a*~ measurements satisfy the mathematical requirement of 0 ≤ *f*~*a*~ ≤ 1, they do not have a probabilistic nature and thus do not necessarily follow the rules of probability theory. Second, *f*~*a*~ quantities are the result of two distinct probabilistic processes, induction of cell death and inhibition of cell division. These processes, even when induced by drugs with the same probabilities, do not necessarily have the same impact on *f*~*a*~. Third, for drugs A and B with *f*~*a*~ \< 1, the Bliss model (when


applied to *f*~*a*~) is unable to account for the difference between being affected by drug A, drug B, or both. For example, consider the combined effect of two truly independent and purely cytostatic drugs A and B, whose phenotypic effects (individually) are described by *P*~*stasis*~ = 1 (and *P*~*death*~ = 0). By Bliss independence when applied to *f*~*a*~ metrics such as viability or normalized growth rate inhibition, the combination of drugs A and B is expected to exhibit substantial cytotoxic effect and thus their combination would be scored incorrectly as antagonistic (*CI* \> 1) ([Fig 4A and 4B](#pcbi.1007688.g004){ref-type="fig"}). To overcome such limitations and to avoid erroneous conclusions about drug combination efficacies, we propose to use probabilities of phenotypic events or their associated rate constants in evaluation of Bliss(optional). If the image is judged to be suitable by the editors, it may be featured on our website and might be chosen as the issue image for that month. These square, high-quality images should be accompanied by a short caption. Please note as well that there should be no copyright restrictions on the use of the image, so that it can be published under the Open-Access license and be subject only to appropriate attribution.

Before you resubmit your manuscript, please consult our Submission Checklist to ensure your manuscript is formatted correctly for PLOS Computational Biology: <http://www.ploscompbiol.org/static/checklist.action>. Some key points to remember are:

\- Figures uploaded separately as TIFF or EPS files (if you wish, your figures may remain in your main manuscript file in addition).

\- Supporting Information uploaded as


the same as probabilities?

• The applicability of estimating phenotypic metrics from fluorescently labelled cell lines in time-lapse movies is not clear. The final paragraph of the discussion should be expanded to provide more compelling reasons and applications for this technique.

Minor comments:

• It might be clearer to label Pdivision as Pdivision(with drug) to make clear that this is the probability of cell division in the presence of drug. This is also what is done in the derivation in the Materials and Methods; it would be nice to have the variables be the same everywhere for consistency.

• You say "could be described" on p7 referring to the derivation of Pstasis. Is this because there are other reasonable ways to derive the equation, or because you are making a set ofexpression of the belief of ones innocence or a confession of the lack thereof, a vow corresponding to an expected divine response, and lastly, a song of thanksgiving. Examples of a general format of this, both in the individual and communal laments, can be seen in Psalm 3 and Psalm 44 respectively.

The Lament of Edward II, if it is actually written by Edward II of England, is the sole surviving composition of his.

A heroine's lament is a conventional fixture of baroque opera seria, accompanied usually by strings alone, in descending tetrachords. Because of their plangent cantabile melodic lines, evocatively free, non-strophic construction and adagio pace, operatic laments have remained vividly memorable soprano or mezzo-soprano arias even when separated from the emotional pathos of their operatic contexts. An early


the Earth has warmed by about 1 degree Celsius. Some fraction of the warming is due to more atmospheric CO2 from burning fossil fuels, but most of the warming is probably due to the same natural forces that have always controlled the Earth’s changeable climate.

Really? What are these natural forces that have always controlled the Earth’s changeable climate? As a physicist you’d like to think that he would understand that long-term warming requires some kind of radiative response; you can’t simply heat the atmosphere and surface and hope it won’t then cool back down again. So if there are natural forces that produce long-term warming, what are they and how do thet operate, and why do they operate when the underlying warming is natural, but not when it’sto meet the new situation. It satisfied her; it made her
happy. It was enough; but no one would think it was enough.

But the house was two miles off. She was safe for the present.
Throughout the journey from London the two-mile drive from the station
had stood between her and the house. The journey was a long solitary
adventure; endless; shielded from thoughts of the new life ahead and
leaving the past winter in the Gunnersbury villa far away; vanquished,
almost forgotten. She could only recall the hours she had spent
shivering apathetically over small fires; a moment when she had brought
a flush of tears to her mother's eyes by suddenly telling her she was
maddeningly unreasonable, and another moment alone with her father when
she had stood in the middle of the hearth-rug with her


feel tight.
Perhaps they only use it for their hands.... Advertisement will do
anything, Pater said.... Perhaps in houses like this--plonk, it
certainly made a lovely hard ring falling into the basin--where
everything was warm and clean and fragrant even Dare's soap could not
hurt you. The room behind her seemed to encourage the idea. But surely
it couldn't be her room. It was a spare room. They had put her into it
for her month on trial. Could it possibly be hers, just her room, if she
stayed ... the strange, beautiful, beautiful long wide hang of the
faintly patterny faintly blue curtains covering the whole of the window
space; the firelight on them as she came into the room with Wiggerson,
the table with a blotter, there had been a table by the door with a
blotter, as"She doats upon her children. What she really wants is someone to
control her; read Shakespeare to her and get her into the air." Mrs.
Corrie did not want Shakespeare. That was quite clear. And it was quite
clear that she wanted a plain dull woman she could count on; always
there, in a black dress. She doated. Someone else, working for her, in
her pay, would look after the children and do the hard work.

"The kiddies were 'riffickly 'cited. Wanted to stay up. I hope you're
strict, very strict, eh?"

"I believe I'm supposed to understand discipline," said Miriam stiffly,
gazing with weary eyes at the bars of the grate.

"We were in an awful fix before we heard about you. Poor old Bunnikin
breakin' down. She adored them--they're angels. But she hadn't the
tiniest bit of a


back the
silk-corded rim of a curtain--a deep window-seat, a row of oblong
lattices with leaded diamond panes. One of the windows was hasped a few
inches open. No sound came in ... soft moist air and the smell of trees.
Nothing but woods all round, everywhere.

                                   6

The next morning a housemaid tapped at Miriam's door half an hour after
she had called her to say that her breakfast was laid in the schoolroom.
Going out on to the landing she discovered the room by a curious rank
odour coming towards her through a half-opened door. Pushing open the
door she foundweak."

Mrs. Craven stared into the fire.

"You take the one who's got the ooftish, my friend," said Mrs. Corrie.

"But you say I'm not to marry."

"You shall marry when my poor little old kiddies are grown up. We'll
find you a very nice one with plenty of money."

"Then you _don't_ think marriage is a failure," said Miriam, with
immense relief.

Mrs. Corrie leaned towards her with laughter in her clear light eyes. It
seemed to fill the room. "Have some more coffy-drink?"

"No, thanks," said Miriam, shivering.

"Sing us something--she sings, Mélie--German songs. Isn't she no end
clever?"

"Does she?" said Mrs. Craven. "Yes. She's got a singing chin. Sing us a
pretty song, my dear."

As she fluttered the leaves of her Schumann album she saw Mrs. Craven
sit back with closed eyes, and Mrs. Corrie still sitting forward in


he understand? She had made him think she was
earnest about the teaching children something. He would be very serious
about their being "decently turned out." She was utterly incapable of
turning them out for the lives they would have to lead. She envied and
pitied and despised those lives. Envied the ease and despised the
ignorance, the awful cruel struggle of society that they were growing up
for--no joy, a career and sport for the boy, clubs, the weary dyspeptic
life of the blasé man, and for the girl lonely cold hard bitter
everlasting "social" life. She envied the ease. Mr. Corrie must know she
envied the ease. Did he know that she tried to hide her incapacity in
order to go on sharing the beauty and ease?

"It is so difficult," she pursued helplessly, and saw himindependent of
it. It did not disturb her. Its overwhelming quality was in the fact
that she had called it to her out of the world. It was as if she had
herself addressed the large bold envelope. She left it. Her sipped
coffee steered her into the tide of the downstairs life. There was
breakfast downstairs, steaming coffee and entrée dishes for Mr. Corrie
and the Kronens, and they were all going off by the early train.

"C'est si bon," sang Mrs. Kronen in a deep baritone, as Miriam drank her
coffee; "de con-fon-dre en un, deu-eux bai-sers." She sang it out
through the quiet upstairs rooms, she met with it the bustle of
preparation downstairs. It was a world she lived in that made her able
to carry off these things without being disturbed by them, a


the conviction that the rest of her life must be spent in a
vain attempt to pay off his debts. Her mind revolved round the problem
hopelessly.... Even if she went on the stage she could not make enough
to pay off one of his creditors. Most women who went on the stage,
Gerald had said, made practically nothing, and the successful ones had
to spend enormous sums in bribery whilst they were making their
way--even the orchestra expected to be flattered and bribed. She would
have to go on being a resident governess, keeping ten pounds a year for
dress and paying over the rest of her salary. Her bitter rebellion
against this prospect was reinforced by the creditors' refusal to make
her father a bankrupt. The refusal brought her a picture of the
creditors, men "on thebaths and little silk dresses and Mr.
Craven treated her as if she were a child he had got tired of petting.
She did not even go fishing with him. She was lying down in her room and
tea would be taken up to her. At least she thought of herself and seemed
to enjoy life. But she was getting fatter and fatter. Mrs. Corrie did
not want anything for herself, except for the fun of getting things. She
cared only for the children and when they grew up they would have
nothing to talk to her about. Sybil would have thoughts behind her ugly
strong face. She would tell them to no one. The boy would adore her,
until his wife whom he would adore came between them. So there was
nothing for women in marriage and


to
her feet. "All _right_," she thought, "if I have more influence over him
than you it's not my fault, not anybody's fault, but how horrid you must
feel."

                                   8

Miriam's trembling fingers gave a frightened fumbling tap at the study
door. "Come in," said Mr. Corrie officially, and coughed a loose, wheezy
cough. He was sitting by the fire in one of the huge armchairs and
didn't look up as she entered. She stood with the door half closed
behind her, fighting against her fear and the cold heavy impression of
his dull grey dressing-gown and the grey rug over his knees.

"It's_wonderful_ that you should say that to me." He stared
at the grass with angry eyes. His mouth smiled. His teeth were large and
even. They seemed to smile by themselves. The dark, flexible lips curled
about them in an unwilling grimace.

"He's in some horrible pit," thought Miriam, shrinking from the sight of
the desolate garden.

"What are you going to do in life?" she said suddenly.

During the long silent interval she had felt a growing longing to hurt
him in some way.

"If I had my will--if--I had my will--I should escape from the world."

"What would you do?"

"I should join a brotherhood."

"Oh...."

"That is the life I should choose."

"Do you see how unfair everything is?"

"Um?"

"If a woman joins an order she must confess to a man."

"Yes," he said indifferently.... "I can't carry out my wish,


sun just
coming round into the green of the conservatory....

She sat impatient, feeling young and strong and solid with joy on the
piano stool. Couldn't mother see her, sitting there in a sort of blaze
of happy strength? She swung impatiently round to the keyboard and
glanced at the open album. There was silence in the room. Her heart beat
anxiously ... some German printer had printed those notes ... in pain
and illness perhaps--but pain and illness in _Germany_, not in this
dreadful little room where despair was shut in.... "Comus," "The Seven
Ages of Man," "The Arctic Regions," beautiful bindings on the little old
inlaid table, things belonging to those sunny beginnings and ending with
that awful agonised figure sitting there silent. She cleared her throat
and stretched a hand out over the notes of a chordshone from his rim of hair. He was
ashamed, but did not know that he showed it.

                                   4

They could always walk home along the smooth grey warm esplanade to tea
in an easy silence. The light blossoming from the horizon behind them
was enough. Everything ahead dreamed in it, at peace. Visitors were
streaming homewards along the parade lit like flowers. Along the edge of
the tide the town children were paddling and shouting. After tea they
would come out into the sheltering twilight at peace, and stroll up and
down until it was time to go to the flying performance


               LONDON, W.C.

                           THE LIBRARY OF ART

   Embracing Painting, Sculpture, Architecture, etc. Edited by
   Mrs S. Arthur Strong, LL. D. Extra cloth, with lettering and
   design in gold. Large cr. 8vo (7¾ in. by 5¾ in.), gilt top,
   headband. 5s. net a volume. Inland postage, 5d.

                            LIST OF VOLUMES

   DONATELLO. Byto Powerball and Mega Millions, though those games are played across dozens of states.

Lottery Director Bishop Woosley has been working to increase profit margins for the lottery as a way to send more money into the fund for college scholarships. Proportionally, Arkansas sells more scratch tickets than any other state and those tickets have much narrower profit margins than numbers games.

Since the lottery launched in 2009, one Arkansas resident has won a top Powerball jackpot and no one in the state has won the top Mega Millions prize.

Players taking a chance on the Natural State Jackpot will have a one in 576,000 chance of winning, much shorter odds than the one in 176 million faced by Powerball and Mega Millions players.

Woosley said the Arkansas-only game is expected to


[NONALCOHOLIC FATTY LIVER DISEASE – A MULTISYSTEM DISEASE?].
With the increasing incidence of obesity and metabolic syndrome the incidence of nonalcoholic fatty liver disease (NAFLD) is increasing as well. These patients have a significant risk of progression to the end-stage liver disease, but also these patients are at increased risk of developing hepatocellular carcinoma. In recent years there is a growing number of publications that support the idea that NAFLD is not just a disease that is limited to the liver, but is associated with a number of extrahepatic manifestations. For example, NAFLD increases the risk of type 2 diabetes mellitus, cardiovascular diseases and chronic kidney disease. Consequently NAFLD has become a growing public health problem. A number of sub-specialists as well as primary care physicians should be awareSimultaneous profiling of lysophospholipids and phospholipids from human plasma by nanoflow liquid chromatography-tandem mass spectrometry.
In this study, an analytical method for the simultaneous separation and characterization of various molecular species of lysophospholipids (LPLs) and phospholipids (PLs) is introduced by employing nanoflow liquid chromatography-electrospray ionization tandem mass spectrometry (nLC-ESI-MS/MS). Since LPLs and PLs in human plasma are potential biomarkers for cancer, development of a sophisticated analytical method for the simultaneous profiling of these molecules is important. Standard species of LPLs and PLs were examined to establish a separation condition using a capillary LC column followed by MS scans and data-dependent collision-induced dissociation (CID) analysis for structural identification. With nLC-ESI-MS/MS, regioisomers of each category of LPLs were completely separated and identified with characteristic CID spectra. It was applied to the


notice a trend here.

1.

2.

3.

All plays with multiple passing options all designed within 10 yards of the line of scrimmage. There were a lot of these plays on Monday night where Sam didn't have a deep option on the play. One thing that's worth expressing is how nice it is to have a QB who can make quick reads and get the ball out on 2 and 3 step drops. We haven't seen that perhaps since Jeff Garcia.

But there were opportunities where Chip opened up the playbook starting with a couple of throws that Sam would love to have back.

Early in the 1st quarter, as predicted, the Eagles went with a 4 Verticals concept against the Falcons Cover 3. As you see below, they line up in a doubleQ:

Kendo UI dataSource get set using javascript object

Just started experimenting with Kendo UI and I'm stuck with how one can use a standard javascript object to use as the datasource.
It's easy enough to initially load the data from the javascript object but I want to be able to get the data back after changes have occurred through user interaction.
Preferably, if this object is somehow synced with the widget, so all one has to do is read/write to this javascript object.
Our data:
var _data = [
{
    eventID: 8,
    title: "Group meeting.",
    start: new Date("2013/06/13 07:00"),
    end: new Date("2013/06/13 08:30"),
    pending:false,
    recurrenceRule: "",
    recurrenceException: "",
    description: "Take


average per pass completion. Like Elijah Holyfield’s 90 yards on 14 carries. Like Riley Ridley’s 5 receptions for 87 yards. And most of this came with starting offensive linemen Andrew Thomas (ankle) and Ben Cleveland (lower leg) out of the game with leg injuries.

Georgia’s final numbers were where they’ve been at the end of games all season, but just slightly skewed toward the pass: 443 total yards, 185 rushing, 260 passing. But that’s not particularly encouraging seeing what Purdue did against the same defense a week earlier (614 yards, 572 passing).

Defense: B

Again, 393 yards was a season high allowed by the Bulldogs, as was Missouri’s 26 first downs. But Georgia’s defenders also put another 7 spot on the scoreboard with a fumble-return touchdown by Campbell in the firstJustin Fields, who ran a quarterback draw for three yards on first down and then left the game for good. And then Jake Fromm was asked to throw on two straight deep corner patterns, which failed.

Once again, halftime adjustments resulted in second-half dividends. The Bulldogs scored touchdowns on their first two possessions of the third quarter and again on the first play of the fourth quarter. But Missouri matched them with two third-quarter scores as well.

The Bulldogs were flagged for seven times for 66 yards in penalties. Smart bemoaned Georgia’s lack of “discipline and composure” Saturday and said, “that’s on me.”

Overall: B

Again, it’s good any time you can win a divisional conference game by two touchdowns on the road. But with a No. 2 national ranking and early


for that
user process.

The process is about to start executing in user space. This can be
determined by checking the Interrupt_State's CS register: if it is not the
kernel's CS register (see include/geekos/defs.h), then the process is about to
return to user space.

The process is not currently
handling another signal (recall that signal handling is non-reentrant).

Set_Handler:

use this routine to register a signal handler provided by
the Sys_Signal system call.

Setup_Frame:

this routine is called when Check_Pending_Signal returns
true, to set up a user process's user stack and kernel stack so that when it
starts executing, it will execute the correct signal handler, and when that
handler completes, the process will invoke the Sys_ReturnSignal system call to go back
to what it was doing.
IF instead the process is relying on SIG_IGN or SIG_DFL,
handle the signal within the kernel.
IF the process hasdefined a signal handler for this signal, this function will have to do the following:

Choose the correct handler to invoke.

Acquire the pointer to the top of the user stack. This is below the
saved interrupt state stored on the kernel stack as shown in the figure
above.

Push onto the user stack a snapshot of the interrupt state that is
currently stored at the top of the kernel stack. The interrupt
state is the topmost portion of the kernel stack, defined in
include/geekos/int.h in struct Interrupt_State, shown above.

Push onto the user stack the number of the signal being delivered.

Push onto the user stack the address of the "signal
trampoline" that invokes the Sys_ReturnSignal system call, and was
registered by the Sys_RegDeliver system call, mentioned above.

Change the current kernel stack such that (notice that you already
saved a


- Ensure you have an extra bulb & batteries. A head lamp is very useful.

* Extra food & water - Carry food which requires little or no preparation (i.e. food bars). Sadly, there is no longer any uncontaminated surface water in the lower 48 states. Bring it with you and be prepared to treat all other water.

* Extra clothing - Include a hat & gloves with your extra clothing. Rain protection is a must, wool is always a good choice for layering. A space blanket is an ideal addition to any kit.

* Fire starter - Must be waterproof. It is a good idea to have three options for fire starting (i.e. a lighter, waterproof matches & magnesium/flint). Practice makes all the difference.

* Candle/fuel tablets - These are remarkablyp[\phi_{\rm xr}(R)]dA (\rho_{\rm r} dA)^{m-1}
     f_{\rm v} p[\phi_{\rm xv}(V)]dA (\rho_{\rm v} dA)^{l-1}
     {\rm\qquad if}~R>0,V>0\end{aligned}$$ $$\begin{aligned}
P(R,0) \propto f_{\rm r} p[\phi_{\rm xr}(R)]dA (\rho_{\rm r} dA)^{m-1}
     (1 - f_{\rm v}) (\rho_{\rm v} dA)^l
     {\rm\qquad if}~R>0\end{aligned}$$ $$\begin{aligned}
P(0,V) \propto (1 - f_{\rm r}) (\rho_{\rm r} dA)^m
     f_{\rm v} p[\phi_{\rm xv} (V)] dA (\rho_{\rm v} dA)^{l-1}
     {\rm\qquad if}~V>0\end{aligned}$$ $$\begin{aligned}
P(0,0) \propto (1 - f_{\rm r}) (\rho_{\rm r} dA)^m
     (1 - f_{\rm v}) (\rho_{\rm v} dA)^l\end{aligned}$$

The normalization Equation \[2dnormeq\] then implies:

\[2dprobeq\] $$\begin{aligned}
P(R,V) = c f_{\rm r} f_{\rm v}
     {p[\phi_{\rm xr} (R)] \over \rho_{\rm r}}
     {p[\phi_{\rm xv} (V)] \over \rho_{\rm


also made to identify sources resolved into two or more NVSS components, such as double-lobed or head-tail radio galaxies. If two radio components in the search area were within $3\arcmin$ of one another and had a flux ratio $<3$, we initiated a test for a double source. This consisted of adding an artificial “source” with the combined flux of the two components and located at their radio centroid (this gave much better results than the [*optimally*]{} weighted centroid used in Windhorst et al. 1984) to the candidate list. We then re-evaluated Equation \[2dgenid\], keeping this new “source” if the reliability was greater than 0.8 or reverting back to the original reliability estimation otherwise. The rms major- and minor-axis position errors for these artificial sources were taken to be $\slantfrac{1}{10}$the Iraq frontier. It has a triple fence, a giant sand berm, thirty-two ‘response stations’ linked to seven command and control centres, all backed up by 240 quick-response vehicles” (1364). Die ironie is: Amerika kan oor honderde kilometers sekuriteitsheinings in Jordanië, Saoedi-Arabië en elders in die Midde-Ooste oprig, maar as dit by die beveiliging van Amerika se grens met Mexiko kom, is daar luide kritiek. “To its south Saudi Arabia has fenced off part of its border with Yemen [“a stretch of frontier about 100 miles long” – 1377]. This project began in 2003 and, as with Jordan’s original plan for the Syrian fence, was originally designed to reduce arms- and people-smuggling from dirt-poor Yemen into the far richer Saudi Arabia” (1370). “The fence still leaves hundreds of


keep people out, and those within to keep people down” (1917).

“There’s a wall at the top of Africa. It’s a wall of sand, of shame and of silence. The Moroccan Wall runs for 1 700 miles through Western Sahara and into parts of Morocco. The whole construction separates what Morocco terms its Southern Provinces along the Atlantic coast from the Free Zone in the desert interior – an area the Sahrawi people call the Sahrawi Arab Democratic Republic. It is built of sand piled almost 7 feet high, with a backing trench and millions of landmines stretching several miles into the desert on each side of the barrier. It is thought to be the longest continuous minefield in the world. Every three miles or so there is aresponse to his reception in the foreign agencies.

Ivanov reported that the building, frame and finish, was made out of predominantly domestic materials. Half an hour earlier, head of the Defense Ministry's Special Constructions Department told us that the headquarters were packed with complex and unusual equipment, giving the impression that it was the ideal “smart” house that the designers of expensive living space strive to create.

“Didn't Microsoft have anything to do with it?” a doubting journalist asked.

Medvedev was standing to the side, along with chief of the presidential staff Sergey Sobyanin, FSB director Nikolay Patrushev and Moscow Mayor Yury Luzhkov, as if in acknowledgment of the fact that today he was not the center of attention. I wondered if they had thought about the children's neurological center that


undermined by unilateral action – action that is not legitimate in international law – undertaken by a number of countries, and by attempts by some countries to unceremoniously impose their positions without taking into account at all the legitimate interests of other partners. And you know what means states make use of when carrying out such action: the economy, political and diplomatic means, and a monopoly on the world media.”

He was apparently getting ready for the European Union summit in Helsinki at the end of the month.the same time, guarantees the maintenance of the stem cell compartment. Asymmetric cell division is a possible mechanism involved in self-renewal. Asymmetric cell division maintains adequate numbers of tissue stem cells and results in two unequal daughter cells: one that enters the differentiation process and another that retains stemness properties \[[@r21]-[@r24]\].

The following sections discuss the evidence regarding the existence of stem cells in ocular structures, mainly in the corneal epithelium. In addition, they describe the most important characteristics of stem cells' residence site (the niche), as well as its role in corneal epithelial renewal and wound healing. The purpose of this article is to provide a comprehensive overview of the field. Since this review is not exhaustive, the author expresses his apologies to all the leaders in the


population seems to correspond to the limbal niche cells, which are located at the limbal stroma and participate in vascularization \[[@r46]\].

### Conjunctiva

For many years, corneal wound healing after injury was explained as a consequence of conjunctival epithelial cell migration and transdifferentiation into corneal epithelial cells \[[@r47]-[@r50]\]. However, the incomplete and reversible conversion of conjunctival cells into the corneal epithelium, the recurrent erosions observed in conjunctivalized corneas \[[@r51],[@r52]\], and the discovery of the limbus as the supposed location of corneal epithelial stem cells (see below), led to the conjunctiva being rejected as the source of cells for corneal epithelial healing. Subsequent studies showed that the conjunctival epithelium possesses its own stem cell niche. Label-retention analyses, expression of keratin pairs, and growth potential assays in cell culture suggested that conjunctivalshift in collagen IV chain isoforms between the limbus and the conjunctiva \[[@r115],[@r116]\]; collagen IV α1(IV) and α2(IV) chains show more intense staining at the corneal limbal border, whereas the α3(IV) chain undergoes an abrupt decrease at the limbus \[[@r116],[@r117]\]. In contrast, collagen types IV (α3-α4 chains) and XII were present in the central cornea \[[@r117]\], although collagen IV (α4 chain) was weakly expressed in this region \[[@r116],[@r118]\].

The differential composition of the limbal BM was extended to other components. α2--α5, β1--β3, γ1--γ3 laminin chains, as well as nidogen-1 and -2, and agrin, were preferentially expressed in the limbal BM \[[@r117]\]. In particular, the limbal BM shows patches of components such as agrin, SPARC/BM-40, tenascin-C, laminin γ3 chain, and versican, which colocalize with ABCG2/p63/K19-positive and K3/Cx43/desmoglein/integrin-a2-negative cell clusters, assumed


(pink cells). In this model, the basement membrane (BM) modulates the self-renewal and proliferative abilities of stem cells and their progeny based on the its composition and structure. Green=limbal BM. Orange=peripheral and central cornea BM. Yellow=conjunctival BM. Blue arrows=stratification of terminally differentiating cells.](mv-v19-1600-f1){#f1}

In the other pathway, asymmetric cell division is restricted to the limbal stem cells, as proposed for most stem cells \[[@r23]\]. If this is true, the decision to leave the stem cell compartment would depend upon asymmetric division, which would be oriented either horizontally or vertically ([Figure 2](#f2){ref-type="fig"}). Consequently, symmetric cell division would be merely proliferative, and would not be essential for cell commitment. Consequently, the orientation of the mitotic spindle during asymmetric cell division would be defined by extrinsic mechanisms, i.e., the niche or microenvironmentreplacing cells lost by terminal differentiation and desquamation. Stem cells located at the LECs divide occasionally \[[@r59],[@r63],[@r93],[@r124]\], and subsequently, their progeny leaves the niche, while undergoing the transient amplification process, which occurs at the basal cell compartment of the peripheral and central cornea \[[@r59],[@r63],[@r93],[@r124]\]. Such transient amplification would imply a gradient or hierarchy of cells with a decreasing proliferative potential along the central cornea \[[@r63],[@r93]\], and comprises a still unknown number of cell divisions, mainly modulated by growth factors and cytokines \[[@r137]-[@r139]\] before cells become post-mitotic and begin to stratify.

After wound damage, trauma, or exposure to tumor promoters such as tetradecanoyl phorbol myristate, the tissue response consists of a rapid 8--9-fold rise in the proliferative activity at the limbus, which then is reduced to pretrauma levels after 36--48


decorin \[[@r157]\].

Although some results have suggested that treating corneal wounds with growth factors or ECM components offers new opportunities for therapeutic intervention, some evidence implies the need for a complex set of growth factors and ECM components, perhaps in a specific three-dimensional arrangement, to improve and accelerate corneal wound healing. This possibility is supported by the application of cultured epidermal sheets as temporary wound coverings on experimental excimer laser corneal ablations. These epidermal sheets increase the reepithelialization rate of wounds by about 60%, in addition to reducing inflammation and scarring at the wound site \[[@r158]\]. Such corneal healing improvement has been explained through the synthesis and release of growth factors, cytokines, and ECM onto the wound bed by cultured epidermal sheets \[[@r159]\]. A similar mechanism for enhancing woundon French as the dauphine of France." "Now you must bid farewell to your party and leave all of Austria behind." "Goodbye." "Mops." "You can have as many French dogs as you like." "It is a custom that the bride retain nothing belonging to a foreign court." "An etiquette always observed on such an occasion." "You're lucky." "Apparently she's quite beautiful." "I'll probably end up with someone who looks like a dog." " Or a horse." " Or a horse." "I've heard she's really nice." " Think they got rabbits here?" " Maybe." "Come on." "You notice anything strange about me lately?" "It's so muddy here." "I know." "My stomach feels a little bit sick." "Are you feeling better now?" "Are you feeling better, Camille?" " I wonder


"They're like icicles." "Well sleep well." "Thank you." " Night." " Good night." "Your hair always looks so pretty." " Oh, do you think so?" " Yeah, it's gorgeous." " It's not what I'm used to." "It is." " It's so nice to be blond." " Have you been to see Léonard?" " No." "My head is in agony." " This morning, I think, you know" " Did he pull it?" "Léonard must've been in a bad mood because he was pulling my hair so hard." "And I want to tell him, you know, it's not my fault if he's had a bad morning." "Don't take it out on my scalp." "That was unnecessary." "Watch it." "I would love to go to the opera in Paris." "Why gois she wearing now?" "Another one of her exotic fantasies?" "She can't pass a mirror without seducing it." "Do you think she's wearing enough jewelry?" "Never enough for du Barry." "She's coming." "Oh, I love your shoes, Victoire." "Oh, why, thank you." "I got them from Christian in Paris." " Oh, I must call on him." " Yes, you must." "He's wonderful." "Madame du Barry would like to offer you some diamonds." "I have enough diamonds." "Snubbing the king's favorite is publicly criticizing the king's behavior." "All you need do is say a few words to her." "Because of rank she is not allowed to speak first." "I certainly have nothing to say to her." "Why should I approve of his cavorting with a harlot?" " Your Royal


I've seen for years." "You enjoyed it, didn't you?" "I think we saw it together." "It was over three hours." "Far too long for me." " Cheers, everybody." " To the queen." "To our queen." "Have a good evening." "And to Raumont for bringing the oysters." "To Raumont for the oysters." "And to Lamballe for bringing the flowers." "For the flowers, beautiful flowers." "And to Fersen for coming all the way from Sweden." " Yes." " To Sweden." "All the way from Sweden." "That is a very long journey, I must say." " How long was it?" " Took about ten days." "Yes, ten days is a very long time." "Personally, I can't travel that much myself." " Far too long." " I must show you this trick."are you laughing at?" " Nothing." "May I be excused?" "Yes, of course, madame." "I might go and ask her." "That way she'll tell us exactly." "Ask her about her family." "The problem of the debt is grave, Your Majesty." "The people of France are hungry." "Sending troops to America is costing more than what we estimated." "But we can't let England win." "We must show our strength." "We will continue aid to the Americans." "And when they went to the queen to tell her her subjects had no bread do you know what she said?" "Let them eat cake." "That's such nonsense." "I would never say that." "And here you're having an orgy with quite a big group." "I think I'm here sucking your toes." "Don't they


by Pearl IRB, who granted institutional review board exemption for analyses of previously collected and de-identified data, deemed as having been performed in accordance with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. All participants provided informed consent for their anonymized data to be used for research purposes prior to participation.

Intervention {#Sec5}
------------

### Standard Intervention {#Sec6}

The standard *Meru Health* intervention has been described in detail previously (Economides et al. [@CR11]; Goldin et al. [@CR19]). Briefly, the intervention consists of 8 modules delivered sequentially over an 8-week period, that include content derived from evidence-based practices such as Mindfulness-Based Stress Reduction (MBSR) (Kabat-Zinn [@CR24]), Mindfulness-Based Cognitive Therapy (MBCT) (Morgan [@CR37]), Cognitive-Behavioral Therapy (CBT) (Beck [@CR2]), and Behavioral Activation Therapy (BAT) (Jacobson et al. [@CR22]). The content includesand those taking antidepressant medication. However, differences in gender (χ^2^ = 3.35, *P* = 0.07), antidepressant status (χ^2^ = 0.74, *P* = 0.39), and country (χ^2^ = 0, *P* = 1) were not significantly different between groups.Table 1Participant demographicsAll participants (n = 96)Enhanced (n = 48)Standard (n = 48)Baseline PHQ-9 (mean, SD)15.3 (3.69)15.5 (3.68)15.1 (3.73)Age (mean, SD)34.3 (6.51)35.8 (6.34)32.9 (6.41)GenderFemale (n, %)78 (81.3)43 (89.6)35 (72.9)Male (n, %)18 (18.7)5 (10.4)13 (27.1)AntidepressantsYes (n, %)33 (34.4)14 (29.2)19 (39.6)No (n, %)63 (65.6)34 (70.8)29 (60.4)CountryFinland (n, %)87 (90.6)43 (89.6)44 (91.7)US (n, %)9 (9.4)5 (10.2)4 (8.3)*PHQ* Patient Health Questionnaire, *SD* standard deviation, *US* United States

The number of participants with a complete post-intervention PHQ-9 score was 40 (83.3%) in the enhanced group and 35 (72.9%) in the standard group (χ^2^ = 0.98, *P* = 0.32). Participants with higher PHQ-9 scores at baseline were less likely to have a complete post-intervention PHQ-9 score (b = − 0.16, *P* = 0.041). No other covariates


regression to adjust for participant demographics and differences in engagement between groups (adjusted OR = 3.44, 95% CI \[1.28--9.26\], *P* = 0.015). The difference in proportions reaching clinically significant improvement in PHQ-9 symptoms yielded a number needed to treat (NNT) of 4 (95% CI \[2 to 12\]) and a Cohen's d effect size of 0.63 (95% CI \[0.16 to 1.09\]). In addition, participants not taking antidepressants (b = − 1.18, *P* = 0.031), and those who completed more intervention exercises ("total complete exercises", b = 0.02, *P* = 0.024) were more likely to report a clinically significant improvement in PHQ-9. A similar pattern emerged if we included total duration of practice instead of total complete exercises in the model (see Methods; b = 0.07, *P* = 0.055).

Linear mixed effects modelling of PHQ-9 scores revealed a significant main effect of time (b = − 0.81, 95% CI \[− 1.16 to(0.76) PP median151311896*PP* per protocol, *ITT* intent to treat, *SEM* standard error of the mean, *w* week

HRV-B Engagement And Patient-Reported Outcomes {#Sec18}
----------------------------------------------

Within the enhanced group, participants who completed a higher total volume of HRV-B practice were likely to experience larger reductions in PHQ-9 symptoms (b = 0.68, *P* = 0.037). This remained marginally significant when controlling for engagement with other intervention practices, despite an increase in multicollinearity (b = 0.64, *P* = 0.053). However, HRV-B engagement did not predict the likelihood of clinically significant improvement when analyzing PHQ-9 change as a binary outcome (b = 0.2, *P* = 0.16).

Discussion {#Sec19}
==========

The present study evaluated the feasibility and impact of incorporating HRV-B training into a smartphone-based, remotely-delivered, psychological intervention (*Meru Health*) for depression. We sought to determine if the enhanced intervention (including HRV-B) was associated with a higher probability of clinically significant improvement


Simultaneous analysis of cerebrospinal fluid biomarkers using microsphere-based xMAP multiplex technology for early detection of Alzheimer's disease.
The xMAP-Luminex multiplex platform for measurement of Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers using Innogenetics AlzBio3 immunoassay reagents that are for research use only has been shown to be an effective tool for early detection of an AD-like biomarker signature based on concentrations of CSF Aβ(1-42), t-tau and p-tau(181). Among the several advantages of the xMAP-Luminex platform for AD CSF biomarkers are: a wide dynamic range of ready-to-use calibrators, time savings for the simultaneous analyses of three biomarkers in one analytical run, reduction of human error, potential of reduced cost of reagents, and a modest reduction of sample volume as compared to conventional enzyme-linked immunosorbant assay (ELISA) methodology. Recent clinical studies          res_mat[i][j] += (mat1[i][k] * mat2[k][j]);
    return;
}

void fill_matrix(int mat[ROWS][COLUMNS])
{
    int i,j;
    for(i=0;i<ROWS;i++)
        for(j=0;j<COLUMNS;j++)
            mat[i][j] = 1;
}

int main()
{
    int n_threads = 10; //10 threads created bcos we have 500 rows and one thread calculates 50 rows
    int j=0;
    pthread_t p[n_threads];

    fill_matrix(mat1);
    fill_matrix(mat2);
    for (j=0;j<10;j++)
        pthread_create(&p[j],NULL,mult_thread,&j);

    for (j=0;j<10;j++)
        pthread_join(p[j],NULL);

    printf("%d\n",res_mat[0][0]);
    return 0;
}

A:

I don't


same.. So much so that the modules under (now both) feet push against the bones and the whole top of my feet look swollen and even bruised sometimes. Walking is usually very uncomfortable and even severely painful. I haven't been able to wear high heels for about 7 years and I used to love them.. Now my shoes are either ugly or uncomfortable. I also use a cane when ever necessary.We have hardwood floors in our home. I haven't walked around anywhere in our house without my Orthoheel slippers for over a year. If my feet are feeling better than usual I might attempt walking around my house for a second, but the pain comes rushing back, so I avoid it. (it feels as if the bones inif your searching for answers and you come across my blog and it helps you in any way, I have been successful.If you haven't already seen my post about Humira *Rheumatoid Arthritis and a rare side effect from Humira*, check it out;I know my case was rare and hopefully you never need to find out..but you may find it interesting if you got this far :)Take Good Care and God Bless!

Thursday, April 21, 2016

Hello =)I have been thinking a lot lately about sharing a difficult time in my life with you all..It occurred to me recently that as I was going through it and searching the Internet for helpful things, very little of it actually helped me in my situation..I am 33 and have Rheumatoid Arthritis.About 3 years


that you made something and the pattern is right on!

Day 5

Day 5

**UpDate**

Day 6I wasn't too sure about this as I added the second color (grey) to the cream.. As I started getting rows done I could see that it looks kind of cool.. If you read the rest of this post you already know the color scheme I am going for. I can't wait to add the next colors so it'll really start coming together! I am taking time every night to work on this project. Our new couch will be here within the next 2 weeks. While I doubt I'll have this DONE by then, I plan to have a pretty good dent in it so I can get it on the floor ASAP!!

Wednesday, April 6, 2016

I'veQ:

Error scoped and unscoped bigquery issue

SELECT
MAX(IF(customDimensions.index=1, customDimensions.value, NULL)) WITHIN hits
AS CustomerID,
date as date
SUM(totals.visits) Visits,
EXACT_COUNT_DISTINCT(fullvisitorid) AS Users,
FROM [xxxxxxx.ga_sessions_xxxxx]
Group by CustomerID;

I am getting the following error when i run the above query "Error: Invalid mixture of scoped and unscoped aggregation functions". Can someone please tell me how to fix this?
Thanks

A:

Using standard SQL (uncheck the "Use Legacy SQL" box under "Show Options"), you should be able to construct a query such as:
SELECT
  (SELECT MAX(IF(index=1, value, NULL))
   FROM UNNEST(customDimensions)) AS CustomerID,
  date as date,
  SUM(totals.visits) AS Visits,
  COUNT(DISTINCT fullvisitorid) AS Users
FROM `xxxxxxx.ga_sessions_xxxxx`
GROUP BY CustomerID, date;

Here is an example query to illustrate the approach:
WITH SampleTable AS (
  SELECT ARRAY<STRUCT<index INT64, value STRING>>
      [(5, "foo"), (1, "bar"), (1, "baz")] AS


15-20 egg sacs in their lifetime. The spiderlings remain in the mother's web for several days after coming out of the egg sac.

Diet and predation
American house spiders usually feed on small insects and household pests such as flies, mosquitoes, ants and wasps. They can randomly attack grasshoppers, butterflies, cockroaches or other spiders depending on their size. If the prey is too agile, the spider will try shooting web at it from a distance before pulling the thread toward itself. Bigger females can also attract baby skinks inside their web by leaving fly remains hanging in it. Once its food dries out, the spider usually drops it to the floor in order to free space in its web, instead of destroying and rebuilding it or changing its location.

Three spidera CUSTOM video message created just for you! These are limited and very likely to increase in value. Remember eventually there will be a traders marketplace for these. When they are gone, there gone! order yours while available.

Lets s tep things up a notch here. Now it is time to look at complete sets. Here you can order an entire custom made picture gallery. There is a lot of specifics on this custom content. You can pick the type of shoot desired, the amount of pictures in your custom set, and you can even choose the WARDROBE & PROPS! Again, this set is hand made by the producer specific to YOUR requests - Very Collectable.

This is for top level Collectors! Get a whole clip from your favorite, Pornstar,


Model or Producer that offers them! Very limited (owners set how many they want to producer per week/month) This is the top of the food chain in Collections. Choose the model, create the script, pick the wardrobe & Props, even add in extra models for your shoot. This is not to be missed. Your the director, order yours from your favorites now before they are gone!may be imposed on a waste vessel by countering the pumping of additional pressuring gas by applying a vacuum to the waste vessel should the pressure within the waste vessel exceed a pre-set limit.
Other attempts have provided a negative pressure (ie, a low pressure) at the outlet port so as to draw the fluid through the outlet port. See, eg, commonly-assigned WO 2012/092564. These systems providing negative pressure to the waste vessel have provided an active pump for applying the negative pressure through a secondary waste vessel to the primary waste vessel as the motive force for the fluid transfer, thus requiring careful control of the negative pressure pump so as not to overdraw the waste fluid beyond the secondary waste vessel.
The art thus lacks a system and


package engine

import (
	"context"
	"testing"
	"time"

	"github.com/MixinNetwork/go-number"
	"github.com/MixinNetwork/ocean.one/cache"
	"github.com/MixinNetwork/ocean.one/config"
	"github.com/go-redis/redis"
	"github.com/gofrs/uuid"
	"github.com/stretchr/testify/assert"
)

type DummyTrade struct {
	Amount           number.Integer
	TakerId          string
	TakerAmount      number.Integer
	TakerFunds       number.Integer
	TakerFilledPrice number.Integer
	MakerId          string
	MakerAmount      number.Integer
	MakerFunds       number.Integer
	MakerFilledPrice number.Integer
}

func TestBook(t *testing.T) {
	ctx := context.Background()
	ctx = testSetupRedis(ctx)
	assert := assert.New(t)

	matched := make([]*DummyTrade, 0)
	cancelled := make([]*Order, 0)
	book := NewBook(ctx, "market", func(taker, maker *Order, amount number.Integer) string {
		matched = append(matched, &DummyTrade{
			Amount:           amount,
			TakerId:          taker.Id,
			TakerAmount:      taker.RemainingAmount,
			TakerFunds:       taker.RemainingFunds,
			TakerFilledPrice: taker.FilledFunds.Div(taker.FilledAmount),
			MakerId:may be adjusted for the Dimensional Weight (e.g. length, width & height) of a package. It is important to note that certain types of products (e.g. glass containers, liquids, fragile, refrigerated or ice packed) will often require protective packaging material. As such, these products will reflect a higher Shipping Weight compared to the unprotected product.

Description

Artisan Quality

Pure Leaf Teas

Fresh

USDA Organic

Brews 60 Cups

Kosher

Origin, India

Chai is an integral part of life in India and simply translates to 'Tea' in Hindi. Calling it 'Chai tea' is considered redundant. Chaiwallahs' (tea vendors) are present at street corners brewing basic black tea with spices especially during early morning.

500 Mile Chai

The tale of '500 Mile Chai' originates from the many late night truck drivers stopping at small Chai stands 'Dhabas' on the highway and asking


Hairpin Mfg. Co. v. Emmerson, 258 U.S. 290 [42 S.Ct. 305, 66 L.Ed. 622]; and American Mfg. Co. v. St. Louis, 250 U.S. 459 [39 S.Ct. 522, 63 L.Ed. 1084].
 The judgment is reversed.
 Edmonds, J., and Traynor, J., concurred.
 CARTER, J.
 I concur in the judgment of reversal, and agree generally with the views expressed in the opinion prepared by the Chief Justice, but I do not believe it is material whether the cooperative marketing association was the agent of plaintiff or was an independent contractor. Assuming the agency relationship existed between plaintiff and the cooperative, the facts remain that plaintiff's income was derived from products produced in California and sold by an agent operating in California. The agent-cooperative dealt with brokers and factors outside the state.will also explore the known repressive effect that p63 has on Notch. We will determine if p63 regulates Notch through repression of ROS-mediated signaling. Our studies will determine how keratinocyte metabolism changes during differentiation and will determine the causal role that metabolic reprogramming plays in promoting differentiation. The work proposed herein will provide the applicant with the training required for development into an independent skin biologist. This proposal builds off of the existing strengths of the applicant and adds to his abilities with additional training in epidermal and epithelial biology. The collaborative environment present at Northwestern University will ensure that the work is completed expeditiously and efficiently. Importantly, the training provided for in this proposal will allow applicant time to take advantage of opportunities for career development available


out at least an hour or so before cooking, so that it
comes to room

temperature.
Wash the rice and soak for 1 hour with 1 tsp of salt.

Meanwhile,
toast the saffron threads on low heat and crumble over the hot milk. Keep
aside. Heat oil in

a skillet,
add the raisins and fry until they are plump. Remove them onto a plate and into
the same pan

add the
almonds and sauté until they turn a shade darker. Keep them aside with the
raisins. To the same

pan add the
onions and fry them, stirring occasionally until they are golden brown. Keep
them aside and

reserve the
left over oil.

Preheat the
oven to 375oF.

As the oven
is heating, bring 10 cups of water to a boil in a large vessel. Add 2 tbsps of
salt. Once it starts

boiling, add
the rice and boil for 3-4 minutes. Draindeep
pan for frying and heat oil. Roll the divided vegetable balls with breadcrumbs.
Fry the balls until they turn crisp and brown. Remove and allow it to cool in a
plate.

In a pan,
heat oil and sauté onion, garlic, ginger, tomatoes and cashews until they are
well cooked. Allow this mixture to cool and then blend the sautéed mixture to
make a fine paste. In a soup pan, add butter and allow it to soften. Pour the
ground paste in the pan. Add the spices and 2 or 2 ½ cups of water. Allow it to
boil for 2 minutes, then simmer, and cook for 5 to 7 minutes. Remove from stove
and allow it to cool.

Take two or
three ladles of the gravy. Place the koftas in a vessel and spoon the gravy on
top very slowly.


Make sure the koftas are completely cooled or they will break
when the gravy is poured on top of them. Let this sit until serving time.

Just before serving, heat up the remaining gravy
for a minute or two and then spoon the rest of the gravy slowly on top of the
koftas. Serve warm with Aparna’s delicious vegetable biryani or roti.

About Us

We have been friends for a long time and we have done it all: bunked classes, watched movies, sleepovers, trips and more. Some friendships last only through the school or college years but looks like this one was meant to be…because we are still friends.
After having cooked for our families and friends for a few years, we had the urge to cook for others. This led to the idea ofradiotherapy. In fact, patients really benefit from surgery when complete excision can be performed, but partial resection has not been demonstrated beneficial \[[@B21]\]. In our cases, partial resection or partial response to chemotherapy resulted in a subsequent rapid progression of the disease. Therefore, complete resection must be the surgical target in every case. But to the patients with locally advanced tumors, which involved adjacent organs and couldn't be completely resected, systematic chemotherapy could be recommended to reduce the tumor mass and prevent metastases outside the mediastinum, if necessery, selvage resection could be performed thereafter.

It is well known that seminomas are radiosensitive tumors \[[@B6]\]. Primary or adjuvant radiations for mediastinal seminomas have been effective in the local control of the tumors \[[@B4],[@B9],[@B15]\]. Based on our observations, it appears that


Introduction
============

In the past decade, genomics research has enabled enormous progress in our understanding of plant genomes with regard to their structure, function and evolution. The rise and continuous improvement of next-generation sequencing (NGS) techniques has allowed researchers to shift focus from (usually small) model plant genomes to larger and more complex genomes of crop plants. Currently, about 34 flowering plant species have been sequenced and are publicly available, and new genomes, including recently the first genome of a gymnosperm, are being published every month. At the same time, novel technological challenges have emerged, particularly in computational data analysis, data distribution and storage. The premiere of the Plant Genomics Congress in the well-connected London-Heathrow Marriott Hotel brought together scientists and technology providers from different disciplines, while it maintained aQ:

Where is the history in IE10 Modern UI?

Apparently there isn't a way to peruse the browsing history in IE10 while in Modern UI. How does one access it?

A:

Open Internet Explorer in desktop mode, the browser history syncs between the two browsers.


but for some reason in Los Angeles, here I an writing the first book about the guy who is arguably the greatest architect in the history of the city, which to me is crazy."

On where in the city is the best spot to see examples of Parkinson's work:
"I stood on the corner of 4th and Spring street, and I turned around 360 degrees and I tried to count how many Parkinson buildings I could see. So if you want an immediate introduction to Parkinson you can see 12, maybe 14 just from that corner. The heart of the city really belongs to John Parkinson."said David Slotnick, a spokesman for the hospital.

De Blasio said at an evening news conference that there were three people in critical condition; the Fire Department put the number at four.

Firefighters initially received reports of a building collapse around 3 p.m., according to the Fire Department. Images on social media showed a large smoke cloud and flames billowing from inside the structure's frame and from the roof.

Smoke was creeping into buildings throughout the area and obscuring views of the skyline, said Andrew Scott Taylor, who works for a public relations firm at 8th Avenue and 37th Street.

"We had a window that was really just about a sliver open in our conference room, and before you knew it the smell of smoke was everywhere. It was very potent," he


the Indonesia Open Super Series Premier and Australian Open Super Series consecutively in June.

Not just that, Srikanth became the only Indian and the fourth man to win four Super Series titles in a calendar year.

Srikanth has had a brilliant year and on Thursday, he was also awarded with Rs 2 crores by the Andhra Pradesh government. Earlier, the Badminton Association of India had also announced a cash reward of Rs 5 lakh for him.

On Wednesday, Srikanth was also recommended for the Padma Shri by the former Sports Minister Vijay Goel.

While Srikanth is receiving all the plaudits for his winning streak, his compatriot HS Prannoy, who he beat in the semi-finals of the French Open, also reached his career-high world No.11.

Photo Credit: AP Photo Credit: AP

Prannoy has consistently performed/* inftrees.h -- header to use inftrees.c
 * Copyright (C) 1995-2005, 2010 Mark Adler
 * For conditions of distribution and use, see copyright notice in zlib.h
 */

/* WARNING: this file should *not* be used by applications. It is
   part of the implementation of the compression library and is
   subject to change. Applications should only use zlib.h.
 */

/* Structure for decoding tables.  Each entry provides either the
   information needed to do the operation requested by the code that
   indexed that table entry, or it provides a pointer to another
   table that indexes more bits of the code.  op indicates whether
   the entry is a pointer to another table, a literal, a length or


Crystal Champagne, in 1996. He did so despite having nothing to do with it.

In 2012, following an appeals process supported by The Innocence Project, Thibodeaux was released. DNA evidence cleared him, at which time the spotlight shone directly on the police who elicited a false confession.

Detectives were convinced the then-22-year-old was guilty. They told him he was lying when he protested his innocence. Then they began describing what would happen to him if he kept lying.

Detectives described to him in detail what would happen to his body if he was given the lethal injection, according to The Guardian.

“They described to me death by lethal injection: organs collapsing, the brain shutting down, extreme pain. That’s what they said would happen to me if I didn’t give them what they2015, 27 Americans were exonerated for convictions based on false confessions. Researchers hope their study will lead to more exonerations in the short term and a change in the way police interrogate suspects in the longer term.

“Depriving a suspect of sleep — whether intentionally as part of an interrogation strategy or incidentally as the result of a lengthy interrogation — may compromise the reliability of evidence obtained from an innocent suspect in an interrogation and put innocent suspects at increased risk,” the study’s authors wrote.

“To this end, our findings provide an additional justification for the importance of videotaping all interrogations, thus providing judges, attorneys, experts, and jurors with additional opportunities to evaluate the probative value of any confession that is obtained.”


= g + -6. Suppose -m = -7*o + 4*o. Is o prime?
True
Let x = 2105 + -1146. Is x composite?
True
Suppose -10*f - 1042 = -12*f. Is f a composite number?
False
Suppose g - 140 = -q, -124 = -g + 4*q - q. Suppose 3*i + 4 = -3*n + 130, -3*n = 5*i - g. Is n composite?
False
Let y(n) = 15*n + 6. Let w(c) = -15*c - 6. Let l(v) = 2*w(v) + 3*y(v). Is l(7) composite?
True
Let r = 454 - 3. Is r a composite number?
True
Let q = 387 + -207. Let b = q + -117. Suppose -4*h + 13 = -b. Is h a composite number?
False
Let f(g) be the first derivative of g**5/60 - g**4/12 - g**3/3 - g**2/2 - 1. Let o(r)Suppose j*m = -m + 45. Is m prime?
False
Let g(h) = -h**3 + 3*h**2 - 6*h + 4. Let s be g(4). Let p = -21 - s. Is p composite?
True
Let y(b) = b**2 - 8*b + 4. Let o be y(6). Let n be (-42)/o - 2/8. Let u = n - -14. Is u a prime number?
True
Suppose 8 = 2*n + 2. Suppose 4 = -n*i + 7. Is 196/6 + i/3 a prime number?
False
Let k(j) be the third derivative of 0 + 2/3*j**3 + 0*j - 31/24*j**4 - 3*j**2. Is k(-3) composite?
False
Suppose 2*h + 6 + 10 = 0. Is (-2)/h + (-891)/(-4) composite?
False
Suppose 0 = -4*s + 6 - 18. Is 196 + s*(2 - 3) a composite number?
False
Let p = -117 - -66.


-i + 3*k = -14. Suppose 6*u - 460 = i*u. Is u a composite number?
True
Suppose 2 = g - 0*g. Let t(a) = 3*a**2 + 3*a - 3. Is t(g) a composite number?
True
Let t(g) = -g**3 + 11*g**2 + g - 12. Let n be t(10). Let d = 165 - n. Is d a prime number?
True
Suppose 2*q - 5*m - 946 = -q, -4*m + 321 = q. Is q a composite number?
False
Let p = -7 + 12. Suppose -5*h + 541 = 4*t - 0*t, 5*h - p = 0. Is t prime?
False
Let y(t) = t + 13. Let k be y(-6). Suppose d = -k - 7. Let a = d - -24. Is a prime?
False
Is (0 - -1) + (13 - 13) +number?
False
Let q(l) = -4*l**2 + 7*l + 11. Let a(t) = -5*t**2 + 6*t + 12. Let w(k) = 5*a(k) - 6*q(k). Suppose -5*n - 16 = -3*n. Is w(n) composite?
True
Let b = -186 + 285. Is b/(-3)*1/(-3) prime?
True
Suppose 3*q - 4*q = -1. Let o(z) = 2*z**2 + z**2 + 5*z + 3*z**3 + q - 5. Is o(3) a composite number?
True
Let o = 4 + -10. Let v be (6/2)/o*-12. Let w(a) = a**2 - 2*a + 2. Is w(v) prime?
False
Let s(f) = 204*f**2 - 2*f - 1. Is s(-1) a composite number?
True
Let h = -77 + 513. Let i = h + -281. Is i prime?
False
Let q(v) = -v - 1. Let o be q(-3). Suppose 2*l - 6 = -o. Suppose 75 + 59


Sexpots Mia And Lana Savor Every Juicy Drop

Juicy assed Mia Malkova and sinfully seductive Lana Rhoades are on a drool filled mission to take a thick cock as deep as they can down their gargle holes. After a bit of pink wink foreplay, the girls are turned on and ready to swap some wet mouth excretions, with Lana close to getting an unexpected mouthful of love nut. The messy gagging continues along with a nice round of eye-watering throat fucking until Lana gets the creamy reward down her throat.new line of digital items at the 2017 International Health and wellness, Racquet, and Sportsclub Organization convention in L.a, CA. The event is attended by hundreds […]

The golden state leads United States in direct food sales WASHINGTON, D.C.– Greater than 167,000 UNITED STATE ranches in your area created as well as sold food with direct marketing practices, causing $8.7 billion in earnings in 2015, inning accordance with the results from the initial Neighborhood Food Advertising Practices Survey released today by the […]

Featured Articles

Delivery Drones: A Dream Deferred?Looking for something to do and also somewhat peckish, he taps an order for snacks and also a TELEVISION streaming device on his tablet computer. Thirteen minutes later on, he becomes part of background. The things were supplied by drone– as well


   'title'     => 'konu',
        'content'   => 'içerik metin 123123',
        'kind'      => 'proposal',
        'priority'  => 'blocker'
        ));

i want to do oauth like that simple but. i coudnt find any good resouce.
edit:
//i did it with basic auth like this.
    https://github.com/gentlero/bitbucket-api/blob/master/docs/repositories/issues.md
//prepare
$issue = new Bitbucket\API\Repositories\Issues();
$issue->setCredentials( new Bitbucket\API\Authentication\Basic($bb_user, $bb_pass) );

//create new issue
$issue->create($account_name, $repo_slug, array(
    'title'     => 'dummy title',
    'content'   => 'dummy content',
    'kind'      => 'proposal',
restaurants…

We can be so sure that the eggs in Japan are safe now. So safe that we can eat them raw as well as fish.

However, how was the situation in Meiji period?

I wonder when the Japanese started to eat raw eggs… Speaking of dishes which we eat with raw eggs what occurs to me first is Sukiyaki.

As I wrote in the previous article, “Finally Solved the Mystery of Washoku“, Sukiyaki is a dish which was invented soon after Meiji Restoration. It is a dish of sliced beef with vegetable slowly cooked in a sweetened soy sauce based sauce in a pot at the table and eaten with beaten raw eggs.

Sukiyaki while cooked in a pot

Sukiyaki, when eaten with a beaten egg

But I found that in Tokyo Sukiyaki was


be medicine with raw eggs, which also were famous for energy agent, before doing something.

Wisdom is better than strength and sexual desire is better than salmonella…

Joking aside, to sterilize salmonella you need to heat in 60 degrees Celsius (140 degrees Fahrenheit) for 10 minutes or for some seconds in higher than 100 degrees Celsius (212 degrees Fahrenheit). So, ladies and gentlemen, Eggs Benedict or Sunny Side Up are not secured as well as raw eggs. Also Custard, Tiramisu, Zabaione and Caesar salad can be dangerous…

I don’t mind at all eating raw eggs not because I’m too eager to have sex but maybe because I’m accustomed to it. But there should be a “trust” toward producers and I buy only the eggs of the producers that I trust. However,his Battlemech.Stefka overheated. His mech shut down to avoid catastrophic failure.Hans centered his crosshairs on the Stormcrow’s center torso and unleashed a devastating alpha. He stripped all the armor. The sensor read-out showed internals damaged and cherry red.Stefka ejected out. “No! How could I have been beaten by a freebirth mercenary? By a Davion?”“You talk too much. A warrior isn’t created by blood or pride, but by experience. I concentrated is all.” Hans smiled. “It was a good match.”“I offer myself as a bondsman,” Stefka Kerensky said, as he bowed.We learned later that a “bondsman” is essentially a slave. When warriors were defeated, they offered their services in payment for not being executed on the battlefield. Or, at least, that’s what I was told.Clan Wolf was interested in


adhesive characteristics. Furthermore, Daf1-negative DE cells (Daf1-DE) turn out to be Foxa2 + Sox17^low^ cells and Daf1-positive DE (Daf1 + DE) cells to be Foxa2 + SOX17^high^ cells. Our results therefore suggest that E-cadherin + Cxcr4 + DE is composed of two populations: Sox17^low^ early DE and Sox17^high^ late DE. Sox17^high^ late DE cells were positive for Daf1, and were slow proliferative and low cell-matrix adhesive cells.

Results {#Sec2}
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Daf1 + DE are slowly proliferating cells {#Sec3}
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Previously, we reported Daf1 as a surface marker, expressed in a subpopulation of DE \[[@CR23]\]. DE are defined as E-cadherin+/Cxcr4+ cells \[[@CR12]\]. When cultured in Activin-containing medium \[[@CR24], [@CR25]\], ESCs sequentially give rise to APS cells on day4 (defined as E-cadherin+/Pdgfra + cells), then to DE cells (defined as E-cadherin+/Cxcr4+ cells) on day 5 (Fig. [1](#Fig1){ref-type="fig"}). A plot of our previous microarray analysis results of the APS and DEin which cells were allowed to adhere to the plate for 90 mins \[[@CR26], [@CR27]\] \[[@CR28]\]. Our results revealed that Daf1 + DE cells showed a lower matrix adhesion ratio than Daf1-DE (Fig. [2d](#Fig2){ref-type="fig"}), and that Daf1 + DE cells were more apoptotic and showed a higher Cleaved Caspase3/7+ ratio (Fig. [2e](#Fig2){ref-type="fig"}) than Daf1-DE. Cells bind to extracellular matrix (ECM) through the ECM receptor, integrin \[[@CR29], [@CR30]\]. We found that expression of several subtypes of the *Integrin* genes, such as *Itgα1*, *Itgα3*, and *Itgα8,* was down-regulated in Daf1 + DE cells (Fig. [2f](#Fig2){ref-type="fig"}). Our results suggest that Daf1 + DE cells have lower adhesion capacity than Daf1-DE cells, which led to a lower plating efficiency and triggered cell death in the attached cells, compared to Daf1-DE cells.Fig. 2Daf1+ DE cells have lower cell-matrix adhesion than Daf1- DE cells. **a**


but not as efficiently into Cdx2-expressing cells, compared to Daf1-DE cells. This might due to a partial loss in differentiation potency of Daf1+ DE cells into the intestinal fate. We previously reported that regional-specific endodermal fates are determined sequentially in the order of stomach, intestine and pancreas, in the chick embryos \[[@CR36]\]. It is possible that Daf1 + DE gradually lose potency to differentiate into intestinal lineages, but retains differentiation potency into pancreatic lineages, compared to that of Daf1-DE.

Cell-matrix adhesion is also necessary for cell differentiation \[[@CR37], [@CR38]\]. Integrin expression promotes DE differentiation from human pluripotent stem cells \[[@CR39]\]. Integrin is a receptor of extracellular matrix expressed in the cells, which enables binding of the cells to the extracellular matrix. Itgα5 and ItgαV are DE-specific *Integrins*. Knockdown of either Itgα5horseradish peroxidase; iPSC, induced pluripotent stem cell, Daf1 + DE, Daf1-positive DE cells; KSR, knockout serum replacement; [l]{.smallcaps}-Gln, [l]{.smallcaps}-glutamine; MEF, mouse embryonic fibroblasts; NEAA, non-essential amino acids; PCNA, proliferating cell nuclear antigen; PFA, paraformaldehyde; PH3, phosphorylated histone H3; PS, penicillin & streptomycin; RT-PCR, reverse transcription-polymerase chain reaction; *Sox17*, *sex-determining region Y-box 17*

Additional files {#Sec22}
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Additional file 1:Daf1-positive cells are negative for Nanog expression. Mouse Nanog-iPS cells, in which GFP expression is driven by *Nanog* promoter \[[@CR45]\], are differentiated into DE. Cxcr4+/E-cadherin + cells were sorted and analyzed for Daf1 and Nanog-GFP expression. Daf1-positive cells are negative for Nanog expression. (TIF 312 kb)Additional file 2:Flow cytometric analyses of the cell cycle. Histograms of flow cytometric analyses of Daf1-DE and Daf1 + DE (n = 5) are shown. Cell cycle was analyzed by measuring DNA quantities using DyeCycle. (TIF 314 kb)Additional


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International research

MDFT-IGD (Internet Gaming Disorder) Study

Members of the original International Cannabis Need for Treatment (INCANT) Study, including Henk Rigter, the INCANT PI from The Hague, Netherlands, are collaborating with MDFT International again on a multi-site, cross-national research project to treat Internet Gaming Disorders (IGD). The study’s clinical sites are in Paris, France (Paris Descartes CPSC - Institut de Psychologie, and Dupre Clinic), and Geneva, Switzerland (Phenix Foundation).

The International Cannabis Need for Treatment (INCANT) Study

In 2003, representatives of the national governments of Belgium, France, Germany, the Netherlands, and Switzerland agreed there was a need in Europe for a treatment program for adolescents with cannabis use disorders and other behavioral problems. Based on a literature review of evidence-based treatments and an international experts meeting,Mosquitoes

What are mosquitoes?

Mosquitoes are a type of pest that is found living throughout most of the world. Adults have slender bodies, long legs, narrow wings that are covered in fine hair, and extended mouthparts (proboscis) that they use for feeding. Only female mosquitoes bite. They feed on the blood of both people and animals to get the protein required to create their eggs. Both males and females, however, use their proboscis for feeding on nectar and pollen, their main food source.

Are mosquitoes dangerous?

Mosquitoes are considered one of the most dangerous pests in the world because of the significant diseases they spread. They have the potential to pick up and transmit a wide variety of diseases and parasites to both people and pets. In developing and/or tropical countries, they


doing it other than two BIs? Still new with programming these. On andover I'd just use an AI point with different resistors on the positions and do an If/Then statement. Not sure what to do on the FEC....before you can post or view full size images in the forums.

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July Challenge: Hebbie's Ale House

Okay, the FHCO's and I are going to try a challenge, but seeing as it is the holidays, and they have relatives visiting, I am just posting a placeholder.
They may use it for a guide once they are back into Snapgallows.
Since this is my first challenge, and I have never seen a vtt, this may not be usable,,,but for FHCO's purposes, since I just invested in the 4th edition and a bunch of accesories for them I thought I would mix the challenge with there first game.
The place holder breaks down as the street Hebbie's is on, the ground floor, the 1st floor (or second, over here), some images of NPC/PC characters