restrictive temperature.

In previous studies, suppressors of DnaA46 thermolability have been mapped to the *topA*, *rpoB* and *seqA* genes \[[@pone.0176050.ref056]--[@pone.0176050.ref058]\]. All of these genes can be linked to chromosomal DNA superhelicity or topology of DNA in the *oriC* region. The lack of *topA* or *seqA* increases the overall negative supercoiling of chromosomal DNA which could assist a defective DnaA protein in DNA unwinding and allow for initiation of DNA replication. In line with this proposal, as a stimulating effect of high negative superhelicity on the DnaA46 activity was shown *in vitro* \[[@pone.0176050.ref059]\]. Such mechanism of suppression was also proposed in the case of decreased temperature sensitivity of the *dnaA46* mutant grown in a medium containing 0.51M salt, which also results in an increased negative superhelicity of the chromosomal DNAshown). Promoters preferring high or low level of negative superhelicity have been identified in previous studies \[[@pone.0176050.ref060]\]. These results also corroborate induction of genes belonging to the regulon controlled by σ^S^, which was shown to depend on the DNA relaxation \[[@pone.0176050.ref061]\]. In the case of suppression of the *dnaA46* temperature-sensitive growth by high medium osmolarity, the lack of requirement for the *rpoS* function (data not shown) and insensitivity to inhibition by coumermycin antibiotics may also suggest that metabolic alterations evoked by high salt are responsible for the suppression.

![Sensitivity to gyrase inhibitors of the *dnaA46* strain lacking a part of acetate overflow pathway (AB) or growing in the presence of 0.5 M NaCl (CD).\
Indicated concentrations of nalidixic acid (AC) or novobiocin (BD) were used. Bacteria were grown on LB


mutants, σ^S^ and *gadX* are necessary for the specific suppressor metabolic profile to occur rather than suppression to result from any single *rpoS*-dependent gene product function. For instance, it has been shown that deletion of *rpoS* strongly induces expression of the PDH genes in *E*. *coli* during exponential phase of growth and GadX also regulates some genes associated with the nitrogen metabolism \[[@pone.0176050.ref065], [@pone.0176050.ref066]\] Alternatively, the conditions for suppression may be weaker in the *pta* and *ackA* strains and require additional, *rpoS*-dependent functions.

In this work, we have also excluded the global increase in negative supercoiling as a potential mechanism of suppression of the DnaA46 defects by the lack of *pta* and *ackA* activity; our results also argue against changes in the DnaA acetylation as the underlying cause. Theresults call also into question the mechanism of suppression of the *dnaA46* temperature-sensitivity by high salt concentration which was proposed to operate via increased negative DNA supercoiling ([Fig 9](#pone.0176050.g009){ref-type="fig"}). High medium osmolarity results in an elevated level of the DnaK protein \[[@pone.0176050.ref067]\], and also leads to significant changes in the cellular metabolism \[[@pone.0176050.ref068]\] which could alleviate the loss of activity by DnaA46.

The reasons for the observed shift in the global gene expression pattern in the absence of the acetate overflow pathway activity are not completely understood. Accumulation of pyruvate implies that the flux to pyruvate exceeds the capacity of the PDH complex to synthesize acetyl-CoA. It was previously suggested that the PDH activity is partially restrained in the *pta* and *pta-ackA* strains due to the accumulation of acetyl-CoA


further investigation, however several possible scenarios can be proposed. The most probable is the one that changes in the level of metabolite or activity of metabolic enzyme, facilitate the functional complex formation by DnaA, directly or via an effect exerted on another regulatory protein. Changes in the level of metabolites may lead to an altered post-translational modification of proteins controlling the replication initiation step or these proteins may themselves interact with metabolites affecting their activity, like for instance, DiaA protein which contains a sugar isomerase domain of unknown function \[[@pone.0176050.ref071]\]. Secondly, metabolic enzymes may directly affect the activity of replication proteins, similarly to their role in the control of a cell division process. Our results suggests that alterations in the PDH complex activity may account for restoration ofDNA replication in the *dnaA46* mutant, and PDH could be a candidate protein directly involved in the control of other processes. However, we excluded the increased pyruvate level as underlying the suppressory effect of the tested mutations, since supplementation of the culture medium even with high concentration of pyruvate has a minor effect on the *dnaA46* strain growth at the restrictive temperature ([Table 2](#pone.0176050.t002){ref-type="table"}). Interestingly, in *B*. *subtilis*, the dihydrolipoamide acetyltransferase (E2) subunit of PDH was identified as a membrane-associated factor inhibiting DNA replication, probably via binding to the AT-rich region present at the origin of replication \[[@pone.0176050.ref072], [@pone.0176050.ref073]\]. Moreover, in the same organism, E2 was identified as an interacting partner of the DnaG primase in a study employing yeast two-hybrid system \[[@pone.0176050.ref074]\]. In addition, most recent studies


Moreover, expression of genes related to the membrane synthesis was affected in the *dnaA46* mutant at the restrictive temperature \[[@pone.0176050.ref077]\]. In our studies, both, the *dnaA46pta* and *dna46ackA* mutant, showed an increased sensitivity to a variety of chemicals and antibiotics as well as an enhanced leakage of Mg^2+^ from the cells, in comparison to the single *dnaA46*, *pta* and *ackA* mutants, even at the permissive temperature (data not shown) which suggests broad changes in the membrane function. The apparent incompatibility of these mutants with *spoT* deletion could also suggest changes in the lipid synthesis, since mutations in *aceE* and *fabH*, which affect synthesis of membrane lipids, were found to be synthetically lethal with a *spoT* deletion \[[@pone.0176050.ref064], [@pone.0176050.ref078]\].

Supporting information {#sec015}
======================

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Click here for additional data file.

The authors      ____________________

    Before BAUER, KANNE, and SCUDDER, Circuit Judges.
   PER CURIAM. While loading chemicals onto a truck, Curtis
Hall felt a sharp pain in his back. This back pain formed the
basis  of  his  application  for  disability  insurance  benefits. An
administrative law judge denied his application, and a district
court  upheld  that  determination.  On  appeal,  Hall  contends
that  the ALJ  improperly  discounted  his  treating  physician’s
2                                                       No. 17‐2628

opinion  and  discredited  his  own  testimony.  Because
substantial evidence supports the ALJ’s decision, we aﬃrm.
                                  I


saying: “My answer was yes and that was an error.”
       On cross-examination by the County, Dr. Wilcox testified that if a person with epilepsy had
not had Dilantin in their system for “several days,” the one-to-four-hour window that he had
discussed might not be sufficient to inhibit seizures. Dr. Wilcox also stated that, given the low level
of Dilantin in Ford’s blood at the hospital after the seizure, he could not say “to a reasonable degree
of medical certainty” that giving Ford Dilantin in the morning would have prevented her seizure that
afternoon.
B.     Procedural background
       Ford brought suit against DeLonghi, Johnson, Lansbach, Smith, and the County. She
claimed, pursuant to 42 U.S.C. § 1983, that the jail officials2006) quote the amended language of Rule 50(b) and explicitly state that “a post-trial
motion for judgment as a matter of law. . . . can only be made as a renewal of a motion made before
the case was submitted to the jury.” (Citing Fed. R. Civ. P. 50(a)&(b)) (Emphasis added.) A review
of Ford’s responses to the County’s post-verdict motions, moreover, shows that Ford did not raise
this particular waiver argument in the district court. Ford’s contention on this point, therefore, is
itself subject to waiver. See United States v. Universal Mgmt. Servs., Inc., 191 F.3d 750, 758 (6th
Cir.1999) (“Because the issue was not raised in the district court below, Appellants have waived
their right to argue the point on appeal.”); see also Marshall v. Columbia Lea Reg’l Hosp., 474 F.3d
733, 739


but subsequently granted the employer’s post-trial motion in which the
employer argued more specifically that the employee’s wrongful-discharge claim under Ohio law
must fail because he had failed to plead or prove one of the necessary elements of the claim (i.e., that
he was an at-will employee). Id. at 354-55.
        On appeal, this court rejected the employee’s contention that the employer had failed to raise
the issue of at-will employment in its pre-verdict motion. Id. at 362. The court called the issue a
“close question,” but explained that
               [a]lthough Rule 50(a) requires a motion for judgment as a matter of
                and inexpensive determination of the case. Accordingly, where Rule
               50(a)’s purpose—i.e., providing notice to the court and opposing
               counsel of any deficiencies in the opposing party’s case prior to
               sending it to the jury—has been met, courts usually take a liberal
               view of what constitutes a pre-verdict motion sufficient to support a
               post-verdict motion.
Id.


defeats Ford’s waiver argument.
According to the County, the argument that it cannot be held liable because there was no
No. 07-1062                Ford v. County of Grand Traverse                                       Page 9

constitutional violation by the individual jail officials is simply a more specific version of its general
argument (made in its motion for a directed verdict) that there was insufficient evidence to establish
deliberate indifference on behalf of the County. “[L]ike the Defendant in Kusens, Defendant in this
case ‘simply restate[d] theGrand Traverse                                     Page 10

generally that “the evidence at trial failed to support Plaintiff’s theory of causation.” Indeed, the
County’s brief in support of its post-trial motion is almost identical to the causation section of the
brief that it filed with this court. Ford also correctly points out that the district court characterized
the County’s post-trial motion as raising only the admissibility question, but the district court
apparently misconstrued the County’s motion in this regard.
         Because the County properly preserved this issue in its preverdict and post-trial motions, we
review


is when execution of a government’s policy or custom, whether made by its lawmakers or by those
whose edicts or acts may fairly be said to represent official policy, inflicts the injury that the
government as an entity is responsible under § 1983.” Id. at 694. A plaintiff bringing a § 1983
claim against a municipality must therefore identify the policy or custom that caused her injury:
                Locating a “policy” ensures that a municipality is held liable only for
                those deprivations resulting from the decisions of its duly constituted
            of such treatment” (internal quotation marks omitted)); Miller v. Calhoun County,
408 F.3d 803, 815-16 (6th Cir. 2005) (explaining that a showing of deliberate indifference “typically
requires proof that the municipality was aware of prior unconstitutional actions by its employees and
failed to take corrective measures,” and rejecting a claim against the county where it had a policy
requiring officers “to contact the on-call doctor in the event of a medical emergency,” in part
because the plaintiff had “failed to adduce independent evidence tending to show that such a policy
was unreasonable”). The County in fact challenged the sufficiency of the evidence in this regard
in its first motion for a directed verdict. But it did not renew such a challenge at any later stage of
the case, having failed to make such a claim in


applicability.

35
The "process of nature" rule holds that, within the meaning of policy provisions requiring disability within a specified time after the accident, the onset of disability relates back to the time of the accident itself whenever the disability arises directly from the accident within such time as the process of nature consumes in bringing the person affected to a state of total [disability].

36
Moore v. American United Life Ins. Co., 197 Cal.Rptr. 878, 892 (Cal.Ct.App.1984)(quotation omitted);  see also McClure v. Life Ins. Co. of N. Am., 84 F.3d 1129, 1133 (9th Cir.1996);  Hawes v. Kansas Farm Bureau, 710 P.2d 1312, 1320 (Kan.1985).

37
The rule was developed for a policy provision far different from that at issue here, designed to ensure a causal relationship between the disability and anstarted to experiment with woodcuts. After studying in the U.S. woodcuts and lithographs became his main media. By the early 1950's he was recognized as one of America's foremost woodcut artists. In 1951 Frasconi married artist Leona Pierce.

Kaleidoscope in Woodcuts, published in 1968, is an accordian fold book, when fully opened it is 130" long. Publisher Harcourt, Brace and World published this book to honor the selection of Antonio Frasconi by the Republic of Uruguay as it's artist at the 34th Biennale in Venice in 1968.

Though picture books compromise a small portion of Antonio Frasconi's career, the work he did in them is exceptional. I would encourage anyone who likes woodcuts to read about him and seek out more of his work.

In continuing the theme of woodcut illustrators,


on time, it is often because of incomplete state records.

Seventeen states have laws that extend the three-business-day federal deadline or require a completed check, according to the advocacy group Everytown for Gun Safety. A bill introduced by Sen. Richard Blumenthal last October would require a completed background check before a sale can proceed. That bill is still in committee, and the Senate has not taken any action on it since it was introduced.

“These numbers are especially alarming given a gaping loophole in current law that allows dangerous individuals like Charleston mass shooter Dylann Roof to legally purchase firearms if a background check isn’t completed within 72 hours,” Blumenthal told ThinkProgress Tuesday in a statement. “No check, no sale must be the rule.”

The National Rifle Association did not returnGreat Grandpa's birthday...helmet Yeah or neh

So we have my DS Great Grandpa's birthday party this weekend. It will be the first time most of the family meets Leo. I'm not worried about wearing the helmet, but wonder if this is one of the times to leave it off for 1.5-2 hours during the party.

I do worry abit about him overheating since at home he tends to wear just a long sleeve onsie to help him regulate his temp with the helmet on.

Don't know if it matters. He is 4.5 month and this is his second weekend with the helmet.

We take ours off 3 times a day for 20 minutes. Over thanksgiving with our families, we did 40 minutes while hanging with them and then 20 for her bath.


New method for recognition of sterol signalling molecules: methinium salts as receptors for sulphated steroids.
In this work, we studied indolium and benzothiazolium pentamethine salts 1-3 as novel type of receptors for the recognition of sulphated signalling molecules (sulphated steroids: oestrone, pregnenolone and cholesterol sulphate). A recognition study was performed in an aqueous medium (1mM phosphate buffer (H2O:MeOH; 99:1 (v/v))) at pH 7.34. The tested salts displayed a high affinity for these sulphated analytes, mainly for cholesterol sulphate. However, no interaction between the salts and control, non-sulphated sterol analytes (cholesterol and bile acid) was observed. The highest affinity for the sulphated steroids was observed for benzothiazole salt 1. This salt also displayed different spectral behaviour from that observed for carbocyanine salts 2 and 3. In this presence of cholesterolto female faces compared to male faces at about 220 ms over left temporal sites. A similar increase was observed in women processing male faces, but it was located approximately 170 ms over central sites. This study thus observed an opposite-sex bias but found that it differed in men and women. In an interesting passive-viewing study (Oliver-Rodríguez et al., [@B32]), ERPs were recorded in male and female participants in response to faces of both genders. After ERP recording, the viewers were asked to rate each face on a five-point attractiveness scale. In male viewers as well as in preovulatory and postovulatory female viewers, a positive correlation was observed between the ratings and the P300 amplitudes in response to opposite-sex faces. The modulation in P300 amplitude was thought to be related


assumed that the increases in bio-electrical potentials in response to opposite-sex faces compared to same-sex faces reflected the processing of other people\'s faces. In contrast, the larger potentials in response to same-sex faces reflected self-sex, self-representation, and body awareness processes linked to the ability to distinguish between self and others, which are thought to be right-lateralized brain functions (Keenan et al., [@B24], [@B25], [@B26]).

Materials and Methods
=====================

Participants
------------

A total of 40 university students (20 women and 20 men) ranging in age from 20 to 30 years (mean age = 22.3 years, SD = 2.7; women = 21.8, men = 22.8) voluntarily participated in the study. All participants had normal or corrected-to-normal vision with right-eye dominance. All participants were right-handed as assessed by the Edinburgh Inventory, and no participants had any left-handed relatives. All participants provided written informed consent.(same or opposite). These results are consistent with a similar finding by Sun et al. ([@B44]), who found increased P300 modulation in a gender-identification task in women. In that study, the data were interpreted to indicate that women conducted a more extensive evaluation process in categorizing male and female faces.

Elevated LP activity has previously been shown in response to attractive faces (Werheid et al., [@B51]), emotional pictures (Dolcos and Cabeza, [@B10]), and faces with emotional expressions (Eimer and Holmes, [@B11]). Because the LP is increased for both unpleasant and pleasant stimuli, it is likely sensitive to arousal rather than emotional valence (Schupp et al., [@B42]).

In a study measuring LP response, He et al. ([@B19]) recorded ERPs in a group of white subjects while the subjects performed a gender-identification


contractors, wrote Shannon Liss-Riordan, the attorney who represented the workers in both cases, in an email. Depending on how many miles they’ve driven and several other factors, individual drivers could receive up to $8,000 in settlement money, she said.

The agreement has several other significant terms, including that Uber will now be required to tell passengers that tips are not included in their fare. Drivers will be allowed to put small signs in their cars that say as much. Uber will also facilitate and help fund the creation of driver associations in both California and Massachusetts, where drivers will be able to elect peers to leadership positions, and bring drivers’ concerns to management.

For two years, Uber pulled out all the stops to fight this case. The company hired lawyerendgame progression which is completely their own. Unlike previous daily quest hubs, the progression this time isn't shared, but unique to every player. Players do daily quests for Marks of the World Tree, tokens which can not only be used to buy gear with, but also to unlock progression of the story.

The interesting part of that is that this personal progression is done without phasing. Thus while two players standing next to each other might see a different scene and different quest givers depending on how far they progressed, they will also see each other, and even be able to do quests together. While there probably isn't a perfect solution to the conflicting demands of people wanting to change virtual worlds, but them having to offer the same


the open world, uninstanced and smoothly contiguous with leveling content. That's apparent because such content does exist and Trion are adding more of it. But unfortunately, as long as the standard dungeon/heroic dungeon/raid dungeon model is also in place, there will be at best a first and second division of endgame.

But then, lots of players might be back in WoW at the end of the year, if SWTOR is really such a dud as some previewers claim.

Highly unlikely, lots of players have left WoW because the game no longer offers them an experience they want to be part of, and a new batch of daily quests is hardly likely to bring them back. Sound likes another weak attempt by Blizzard to save a dying game and with 1.2in Everquest. It was quite the opposite, people who were idiots quickly found themselves without anyone to group with. And if someone in your guild wronged others, you booted them and you made restitution. Reputation was everything.

"The solo game will never be a sufficient substitute for raiding unless the rewards are equalized. If they are, raiding will end."

This points out the fundamental problem with raiding -- it isn't fun. If it were actually fun, then people wouldn't need gear rewards in raids at all. The best gear could be obtainable through solo questing, crafting, and pvp, and then could be used for raiding. Raiding would still be the end game, but you'd raid because it was a fun end game -- not in order to get even better


to...(View More) participate in an activity that illustrates the phases of the Moon. He asks one student to represent the Earth and another student, the Moon. The student representing the Moon makes one complete rotation or one full spin on their axis while standing in one spot. Andrew guides students to see that the Moon makes a full rotation in the same amount of time it takes to revolve around the Earth one time. The demonstration is followed up by a hands-on lab where students draw the placement of the moon in revolution and rotation. Includes teaching tips and discussion questions.(View Less)

This is an activity about the rotation of the Moon. Learners use a penny and a quarter to model that the Moon does indeed spin on itsFinding no suitable buyers and not wanting their beloved Effie broken up or just left to rot. They decided to donate the hull for sinking to Preserve Our Wrecks Kingston. In the spring of 1993 they ran her for the last time to the Metal Craft Dry dock to be made ready for sinking.

On Sunday October 17 1993 twenty five years from the date of her christening the Effie Mae was put to rest beside one of the historic shipwrecks she visited so many times before. To-day she is a valuable and much visited dive site sitting upright beside the wreck of the Schooner barge Aloha. A silent tribute to the two families who sailed and cared for her during her life above the waves..

Local divers affectionately refer


crazy forms or anything. I just need to know how much I have to pay when I go to buy something, which leaves all the mysterious calculations to the nice person working the register. Or at least the computer they use to ring me up.recipients. In a recent NIH study, adult females were followed prospectively with cervical cytology testing long-term after HSCT for hematological malignancies (median: 7 years post-transplant;Savani and Stratton, Biol Blood Marrow Transplant. 2008 Sep;14:1072). One-third had HPV-related SIL (median time to SIL 51 months, range: 22-108) including high-grade SIL in 20%. Patients requiring continued ImmunoSuppressive Therapy (IST) had the highest risk (odds ratio OR 4.6, 95% confidence interval CI 1.1-16.4;P = .019). These abnormal cervical cytology results represent HPV disease that does not appear to be newly acquired HPV disease as many are not having intercourse. It is reasonable to hypothesize that a loss of antibody titers and/or T cell immunity to HPV can cause recurrence or reactivation of HPV disease. This high incidence of SIL in long-term HSCT


    ]
      };
      var options = {
        chart: {
          width: 1160,
          height: 540,
          title: 'Monthly Revenue',
          format: '1,000'
        },
        yAxis: {
          title: 'Amount'
        },
        xAxis: {
         set to the hyperfocal distance means most of the scene will be in focus with every shot. Want to ‘stealth shoot’ (snapping pictures without putting the camera up to your eye?) Set it at hyperfocal distance and snap from waist level, or turn on live view in manual focus mode and frame on the LCD just snapping away.

Manipulate the Plane of Focus

When you’re working with a narrow depth of field, visualize the depth of field as a flat sheet parallel to the camera’s sensor where the subject is. If you change the angle of the camera in relation to the subject slightly, the depth of field across the scene changes, too. Picture a photo of a huge group of people, maybe hundreds, standing in a field. You’ve seen


Street consensus estimate of $28.17 billion, according to IBES data from Refinitiv.

Revenue growth was aided by British pay-TV group Sky, which the company acquired for $39 billion in 2018. The business generated fourth-quarter revenue of $5.04 billion, beating the average estimate of $4.82 billion.

For the fourth quarter Comcast’s NBCUniversal segment, which includes NBC Entertainment and Universal Pictures, reported revenue of $9.15 billion, down 2.6% from a year earlier. Revenue at the filmed entertainment unit fell 21% from the same quarter a year earlier.

Net income attributable to Comcast rose to $3.16 billion, or 68 cents per share, from $2.51 billion, or 55 cents per share, a year earlier.

Excluding items, the company earned 79 cents per share. Analysts on average had estimated the company to earn 76 cents.

Comcast increased itsprior to your trip* 60 days prior to your trip you'll make your final payment* Approximately 3 weeks prior to your trip you'll receive your electronic travel documents. * You'll set up a time to discuss your travel documents and to answer any questions prior to your travels* While you are traveling you have 24/7 support from your travel advisor* Our job is not complete until you return back to the USA with rave reviews!

Do I Earn Points if I Book Through You?

Asimina Tours is classified as a TRAVEL COMPANY with an MCC CODE of 4722

This means that the way we are “coded” on the credit card processors system we are classified as a TRAVEL COMPANY providing travel information and booking services.

This means that when you pay by


\[[@CR12]\]. Many groups targeted the AAVS1 locus using ZFN, TALEN, or CRISPR-Cas9 and described stable transgene expression \[[@CR3], [@CR13]--[@CR21]\]. The AAVS1 locus is an excellent choice for transgene expression, so we inserted human full-length *F9* cDNA into the AAVS1 locus of iPSCs of a HB patient using CRISPR-Cas9 in this study. The edited iPSCs were then induced to hepatocytes able to secrete human FIX (hFIX), and these hepatocytes were able to be transplanted into non-obese diabetic/severe combined immunodeficiency disease (NOD/SCID) mice in the short term.

Methods {#Sec2}
=======

Generation of iPSCs of the HB patient {#Sec3}
-------------------------------------

The patient with HB was clinically and genetically confirmed in the Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences, Tianjin, China. iPSC lines were generated from peripheral blood mononuclear cells (PBMNCs), usingendonuclease; the digested products were then connected by the T4 ligase; and, finally, sequencing was carried out to ensure that no error occurred.

Transfection of HEK293T cells and iPSCs {#Sec9}
---------------------------------------

To test the efficiency of the constructed plasmids, HEK293T cells were firstly transfected using the Lipofectamine 2000 transfection reagent (Invitrogen). iPSCs were electroporated with the same plasmids, using the Lonza Amaxa Human Stem Cell Nucleofector Starter Kit and program B-016. Forward primer (F1) 5′-TTCGGGTCACCTCTCACTCC-3′ and reverse primer (R1) 5′-GGCTCCATCGTAAGCAAACC were used to detect the full inserted fragment. When insertion failed, the amplification length was 468 bp; if successful, the amplification length was 4.9 kb. Forward primer (F2) 5′-TTCCGCATTGGAGTCGCTTTA-3′ and reverse primer (R2) 5′-GTGGGCTTGTACTCGGTCATCT-3′ were used to detect the 5′ junction point of insertion. When insertion failed, nothing could be amplified;


from urine cells \[[@CR27]--[@CR29]\]. PBMNCs have been reported as the best cell source for cell reprogramming owing to their better quality, quantity, and easy accessibility \[[@CR30]--[@CR34]\]. Therefore, we generated iPSCs of HB patients from PBMNCs in this study.

The development of genetic engineering tools opens up many opportunities for the treatment of human hereditary diseases. Notably, the CRISPR-Cas9 system is the most powerful homologous recombination-based gene editing method, and has been used in human studies of beta-thalassemia, cystic fibrosis, and sickle cell disease \[[@CR35]--[@CR38]\]. CRISPR-Cas9 has been used in hemophilia to correct structural variations and chromosomal inversions of HA patients \[[@CR29], [@CR39]\] and somatic mutations of HB mice \[[@CR40]\]. A previous study suggested that GC-rich sgRNAs improved targeting efficiency, whereas poly(U) stretches close to the protospacer-adjacent motif (PAM) sequencehot Hydrogen outside, the tubes are both robust and at the same time frighteningly fragile. Hugh forces work on the LOX posts, especially during start up. Vibration forces are high throughout. And if one of those posts breaks off at the root, well, very bad things can happen. In the cool NASA parlance, a LOX post failure is CIL Crit 1. Loss of vehicle, loss of crew ‘promptly’ upon just one failure.

To eliminate the potential of a LOX post failure, inspections of the hundreds of LOX posts is performed with ultrasound. If a post shows signs of ‘fatigue’, the remedy is to plug it at the base. They use a gold pin, about the size and shape of a bullet. In the history of the program, over 200


[Cost analysis of the use of botulinum toxin type A in Spain].
To estimate treatment costs of blepharospasm, cervical dystonia(CD), upper limb spasticity (ULS) and spasticity in children with cerebral palsy (SCCP) with botulinum neurotoxin type A (BoNT-A) in Spain. Annual BoNT-A treatment costs were calculated (2013 ex-factory price () applying RDL 8/2010 and RDL 9/2011 deductions), based on initial dose (id), average dose (ad) and maximum dose (md) according to Summary of Product Characteristics of Botox® (100U/50U), Dysport®(500U) and Xeomin® (100U) and considering the use of complete vials.In addition, annual treatment costs were calculated considering the useof vials in more than one patient and also patient population annual treatment costs based on diseases' prevalence. Annual BoNT-A treatment costs per patient were estimated at between 265 and 2,120 withswing states reflects, above all, the changing demography of each party’s electoral coalition. The working-class white voters underpinning Trump’s support represent a much larger share of the vote across the Rustbelt than the Sunbelt, whether using data from the exit polls or the Census post-election survey (which consistently identifies non-college whites as a large share of the electorate than the exit polls do). The Census results identify non-college whites as at least 54 percent of 2012 voters in all five Rustbelt states—and no more than 44 percent in any of the Sunbelt states. And except for Florida, the Rustbelt states, as a group, are also generally older, at a time when Republicans are dominating among whites older than 45.

Contrasting dynamics are molding the Sunbelt states. Diversity is the


and the 53-year-old man who calls himself Wizdom Williams, were sharing the tent set up on Mission Street, a location she said would be permanent for only a few days before police scooted them away.

HOW TO HELP: Donate to The Chronicle's Season of Sharing, helping 4,500 families a year, with 100% of all money going to assist those in need before they become homeless.

She didn't mince words when I asked her, "What's dating like when you're living on the streets?"

"You feel like two train wrecks," said Alexis, who grew up in San Francisco and attended Pepperdine University before being sucked into a crippling life of drugs and addiction. "It feels like a train wreck junkyard, because you're dating someone else who also doesn't have housing. You never planand +1.51 lines [+8 letters] [Group S], P < 0.01) associated with a significant reduction in optical coherence tomography central thickness (-99.9 μm [Group A], P < 0.01 and -62.2 μm [Group S], P = 0.05). Six months after surgery, the microperimetry showed more numerous and deeper microscotomas in the Group A than in the Group S (change in the number of microscotomas: 2.09 vs. -0.10, P = 0.06; change in deficit severity score: 13.18 dB vs. -2 dB, P < 0.01 for Group A and S, respectively). The number of microscotomas and also severity were increased in 63.6% of Group A patients and in only 20% of Group S patients. Microscotomas were most frequently located in IEMM and/or ILM areas. Internal limiting membrane peeling has progressively become


where apparently it would be impossible for any 17-year-old to find a link to sexed.org.) The authors specifically call out Free Press and Public Knowledge for transforming the Internet’s “sensible design principle into something approaching an ideology.” “… [T]he culture of the Internet is to oppose anything approaching actual culture. Strong cultures edit and constrict,” they say. Well, it depends what you mean by “culture.” What is the culture of paper, or of books? There isn’t any. Anything goes. Of course society can control what gets printed–except that the culture of the U.S., as defined in its constitution, is that it can’t be controlled very much–and not in ways, as the Supreme Court has repeatedly held, that would unreasonably restrict what adults can legally see.

Nonetheless, Goldberg and Schulzare smaller and have slightly fuller growth habit than plants of xe2x80x98Favoritaxe2x80x99.
2. Plants of xe2x80x98Valentinexe2x80x99 start flowering later, but flower more abundantly than plants of xe2x80x98Favoritaxe2x80x99.
3. Leaf blades of xe2x80x98Valentinexe2x80x99 are smaller, lighter green and less glossy than leaf blades of xe2x80x98Favoritaxe2x80x99.
4. Peduncles of xe2x80x98Valentinexe2x80x99 are thinner, weaker and shorter than peduncles of xe2x80x98Favoritaxe2x80x99.
5. Spathes of xe2x80x98Valentinexe2x80x99 are smaller, have lower length to width ratio; are held higher above foliage and have better longevity on the plant than spathes of xe2x80x98Favoritaxe2x80x99.
6. Spathes of xe2x80x98Valentinexe2x80x99 are deep red, whereas spathes of xe2x80x98Favoritaxe2x80x99 are orange-red.
7. Spadices of xe2x80x98Valentinexe2x80x99 are smaller and cream-colored, whereas spadices of xe2x80x98Favoritaxe2x80x99 are pink-purple.
The new cultivar can be compared to the known Anthurium cultivar xe2x80x9875-10xe2x80x99, disclosed in U.S. Plant Pat. No. 9,355, a/k/a Red Hot(trademark). The


kinase domains share 84% identity and differ in the active site by just a single amino acid. This striking homology suggests an ATP-competitive ligand would not be expected to exhibit significant aPKC isoform selectivity.
The aPKCs have been implicated in a diverse number of signalling pathways, demonstrating both redundant and distinct signalling functions. Both isoforms have emerged as central players in the mechanisms that regulate the establishment and maintenance of cellular polarity in multiple cell types (reviewed in Suzuki, A., and Ohno, S. (2006). The PAR-aPKC system: lessons in polarity. J Cell Sci 119, 979-987). Genetic dissection of their functions using knockout mice have also revealed preferential roles for PKC in the regulation of NF-kB signalling (Leitges, M., Sanz, L., Martin, P., Duran, A., Braun, U., Garcia, J. F.,9/11 Babies on Dads: 'I Never Met Him but I Know I Love Him'

Ten years ago, a sad sisterhood of pregnant women gave birth to children who would never know their fathers because the men had perished in the holocaust of 9/11 terror attacks.

Now those babies are almost 10 years old.

They are children who were never able to share a living moment with their dads, but created memories out of ordinary objects such as a lacrosse stick, a biking jersey and even backstage passes from rock concerts.

Morgan Rodriguez still wears the firefighter medallion belonging to her father, Anthony Rodriguez. Ron Milam Jr. said he had his father's basketball.

"This is a picture of my father," Phelan Halloran told ABC News' Diane Sawyer of Vincent Halloran. "I really love him.


from him and I carry some of them with me."

"It could be something silly like Jack doesn't like mayonnaise," said Terilyn Patrick-Esse of her son Jack Esse. "Well neither did Daddy Jim."

"My mom says I have his eyes," Grace Danahy said. "She said that he was free-spirited and she said that I was too."

"They say I look like him," James Carson said of his father, James Carson.

"I feel like his humor was a lot, a big part of me," said Sean O'Neill.

9/11 Children Find Solace in Reunion

Ron Milam Jr. said sometimes he asked his mother whether his father looked like him.

"She said, 'Yes. I look exactly like him.' It makes me feel closer to him for some reason," he said. "I don't know why."

Kellie Lee said that herShare Post:

No trip to Coney Island is complete without a little nosh. Whether you want a quick bite before hopping on the Cyclone, or you are looking for a quiet dinner date, the People’s Playground has it all, from your classic corn dog to prosciutto-watermelon appetizers. Here are a couple of spots you should be sure to stop by on your next visit!

Al Cavallino

This pizza shop by the B&B carousel opened just two months ago, and it is already drawing praise from locals. The restaurant serves high-end personal pizzas as well as “panni-pizzas,” sandwiches made from oven-baked pizza dough stuffed with cheese, veggies, and more. The shop is dedicated to keeping all the details just right, said the restaurant’s manager and ‘za rockstar.

“We use top notch mozzarella cheese,”


初始化顺序，在initializer中调用可能被子类override的成员的风险
   1. *15m* Object API适用性，对象（属性集）工厂 vs 接口（封装）实现，OOP实践（语言中立）
   1. *15m* 语法对称而语义不对称，own property存储，解构和枚举问题，"field" 术语问题
   1. *15m* `#`符号
1. *15m* 总结
   1. 投票结果更新（如果需要的话）+总结
   1. 后续计划（整理会议纪要、翻译、宣传、提交给tc39）
   1. 建立讨论组和下次会议的计划
   1. 感谢host
1. *30m* buffer
1. 晚餐

## 备选内容（未来会议内容）
1. 内建 vs decorator
    1. placement
    1. this 绑定问题
    1. 可见性：protected, friend, internal, package private 等
    1. 修饰：readonly、自动accessor、abstract、final、override、open 等
1. 已经被否决的alternative提案介绍
   1. private symbol
   1. classes 1.1
   1. symbol literal
1. 核心设计要素
   1. 什么样的提案对TS才是友好的
   1. 什么样的提案符合OOP最佳实践
   1. 什么样的提案符合JS程序员预期
   1. 可能的public语义
      1. [[Define]] own property
      1. [[Set]]
      1.Q:

Bukkit - How to read from a YML file and use in an if statements

I would like to read data from my config.yml. It's saving data like (playerName: value). I want to check, if player's name value is equals to 0, then ban him. But still don't know how to read those values. I was searching around spigot forum but nothing worked.
@EventHandler
    public void OnDeath(PlayerDeathEvent event) {
        Player player = event.getEntity().getPlayer();
        String playerName = player.getName();

        int lives;

        if (!livesMap.containsKey(player)) {
            // Set the default amount of


appointment on time or whatever then to actually focus on the
act of driving.

The 1% where I don't welcome self driving cars is when I'm out for a drive on
any given Sunday in a nice sporty car and am driving purely for the thrill of
driving. That 1% of the time, I want to be in control. I want to feel the road
through the steering wheel; the sound of the engine and if weather permits,
the breeze through the windows.

Every other time - on my way to work; grocery shopping; running errands - go
ahead, drive me. But give me the option to take control when I want to.

As much as everyone says this is right around the corner, I still think a car
driving itself will be limited to nice weather. No(AP) document was generated by the coach after each session for the participant, where the plan discussed and goals set were recorded. We accessed an electronic repository where APs for participants were stored. We performed a content analysis of all available APs (n = 1127), which is a method to abstract information from text to create a dataset amenable for statistical analysis and research ([@bb0065]; [@bb0070]; [@bb0055]; [@bb0025]). We developed a coding scheme to abstract the following content: program goal(s), smoking status, and amount of desired weight loss. Data abstractors were trained on how to use the abstraction form (a nursing student and JHHC employee). A study team member (NR) reviewed their initial abstractions for accuracy and met with abstractors regularly to address questions and provide clarifications. If this study


*6 n. 6, 2009 U.S. Dist. LEXIS 129474 at *19 n. 6 (N.D.N.Y.2009); Colodney v. Continuum Health Partners, Inc., 2004 U.S. Dist. LEXIS 6606 at *40 (S.D.N.Y. 2004). Similarly, if plaintiff's allegation is assumed to mean that she timely elected to continue coverage but that her election was, for some reason, not honored by the plan or its insurer, plaintiff has made no factual allegations by which the actions of those parties could be attributed to the District.
If one views plaintiff's allegation regarding COBRA coverage as a claim that the District discriminated against her with respect to the relevant terms of her Settlement Agreement, which provided that plaintiff's health benefits would be extended for more than a year after she stopped working, through June 30, 2008, plaintiff hasIt has previously been proposed to continuously supply electrical contacts to a substrate by severing contact elements from a strip of contact material either in wire or tape or band or strip form so that it can be welded on a substrate carrier made of sheet metal, or wire at predetermined positions on the carrier. The contact elements which have been cut off are guided through a contact guide path which extends from the cutting or severing device towards the welding position, providing a feed movement in forward direction and a retrace movement in backward direction having different lengths. In such an apparatus--see the referenced German publication DT-AS No. 2 250, 461--the contacts are applied to the welding point at an acute angle. The wire of contact material


thousands on edge since the start of 2017. Threats called into JCCs in at least five states, including New Jersey, prompted evacuations Jan. 9.

At least 20 centers and day schools were targeted in a new round of threats, the national Jewish Community Centers Association told NBC News Monday. Among those targeted were facilities in Pennsylvania and in the New York City area like Plainview, where 400 people — including 200 preschoolers — were forced to leave the building, police said.seven pairs amplified three loci (Guo et al., [@B9]), and only one amplified four loci. Out of 1484 eSSR loci, 691 were distributed in At genome, and 793 were distributed in Dt genome; while of the 1609 gSSR marker loci, 798 and 811 were located in At and Dt genomes, respectively (Table [2](#T2){ref-type="table"}). Of the 3093 mapped loci, 2580 were co-dominant loci, with 1245 and 1335 distributed on At and Dt genomes, respectively, whereas 513 were dominant loci of which 225 loci received alleles from CRI 12-2 and 288 from *G. tomentosum*.

######

**Main Characteristics of genetic map**.

  **Chromosome**      **No. of marker loci**   **Recombination or map Size (cM)**   **Avg. distance b/w loci (cM)**   **Smallest gap (cM)**


marker to cover it fully (Park et al., [@B33]; Han et al., [@B12]; Guo et al., [@B9]; He et al., [@B14]). In lieu of this fact new gSSRs from *G. raimondii* were developed to cover more genome and construct high density map. In this study 51 loci could not be placed on the map because of missing data or presence of stutter bands due to DNA slippage during PCR complicating the interpretation of bands. Due to stumble bands heterozygotes perplexed with homozygotes leading to the cynicism in the estimate of heterozygosity. However, this can be subdued by adding genotypes of known band size. The high density cotton map was assembled based on the 3093 SSR mapped markers covering 4365.30 cM with an average inter-marker distance of 1.48 cM.old stuff and had been keeping my eye out for a truck to restore. The grain truck was one her grandfather had purchased new. It hadn’t been used in years and they said they would consider selling it to me. After looking it over I decided that it probably wasn’t the truck for me. That is when the gent said “Well I have a 1929 AA truck in the barn. Would you be interested in it?”

Silly question… Yes, I was certainly interested! Turns out the truck hadn’t been run in 50 years. For 10 years it sat out in a pasture and then the following 40 years it sat in the barn. The barn had settled quite a bit. So much so I had to dig trenches for


the g'th term of 24, -17, -86, -183, -308, -461, -642?
-14*g**2 + g + 37
What is the z'th term of 1906, 1905, 1904?
-z + 1907
What is the o'th term of -401, -787, -1165, -1529, -1873, -2191?
o**3 - 2*o**2 - 387*o - 13
What is the y'th term of -68, -172, -286, -416, -568, -748, -962, -1216?
-y**3 + y**2 - 100*y + 32
What is the p'th term of -119, -134, -149?
-15*p - 104
What is the y'th term of -278, -257, -236, -221, -218, -233, -272?
-y**3 + 6*y**2 + 10*y - 293
What is the g'th term of -447, -446, -445, -444, -443?
g - 448
What is the r'th term of 208, 209, 210, 211?
r + 207
What is the k'th term of 34, 66, 98, 130, 162, 194?
32*k + 2
What is the r'thEvenflo Maestro Sport Review

The Evenflo Maestro has long been a popular forward facing only combination car seat. It’s gained quite a following as a lightweight, easy to install car seat for travel. Evenflo has updated this old favorite with a few new features, including updated cupholders and a much larger belt path. But luckily the Maestro Sport is just as versatile and affordable as the original!

CSFTL Quick Stats

Lower anchor weight limit: 50 pounds

Forward facing weight range: 22 to 50 pounds

Forward facing height range: 28 to 50 inches

High back booster weight range: 40 to 110 pounds

High back booster height range: 44 to 57 inches

Lowest harness position: 13 inches

Highest harness position: 18.5 inches

Booster belt guide position: 19 inches

Lower anchors permitted in booster mode

Expiration: 6 years

Measurements

Width at widest point (shoulder area


be used on a plane in harness mode. Like all booster seats, it’s not approved for air travel without the harness since airplanes only have lap belts and booster seats require a lap and shoulder belt.

Important Information: Where to Find

Manual Storage

Evenflo Maestro Sport: manual storage

The manual was a little unclear because the photos pointed to the lower anchor connector storage locations. We reached out to Evenflo about this — they clarified that the manual should be rolled and stored under the seat shell near the lower anchor connector storage.

Date of Manufacture and Expiration

Evenflo Maestro Sport date of manufacture label

The manufacture date and expiration date are both located on a label on the backside of the seat’s shell.

FAA Approval

Evenflo Maestro Sport FAA approval label

The Maestro Sport is FAA approvedTechnicians. However, our reviews and educational materials are OUR opinions and are not that of Safe Kids, NHTSA, or anyone other than us. We are not liable for anything anyone says or does as a result of reading our opinions on this site.

Affiliate Programs

Car Seats for the Littles is a participant in:

The Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.

The Walmart (Rakuten Marketing) Program, an affiliate advertising program designed to provide a means for sites to earn commissions by advertising and linking to Walmart.com.

The Target Affiliate Marketing Program, an affiliate advertising and marketing program that pays advertising fees to sites that advertise and link to Target.com.

Copyright

Car Seats for the Littles®


know of a better way.
  let springConfig = getSpringConfigForLight(
    [ON_PROPS, OFF_PROPS, BRIGHT_PROPS],
    status
  );

  useOnChange(() => {
    if (!isPlaying) {
      return;
    }

    const statusShouldReset = status === 'flash' || status === 'fade';

    springConfig.reset = statusShouldReset;
  }, lastEventId);

  const spring = useSpring(springConfig);

  return (
    <group>
      <mesh position={position} rotation={rotation}>
        <cylinderGeometry attach="geometry" args={[radius, radius, length]} />
        <animated.meshLambertMaterial
          attach="material"
          emissive={color}
   maximum potential. A Cellar Selection designation does not mean that a wine must be stored to be enjoyed, but that cellaring will probably result in a more enjoyable bottle. In general, an optimum time for cellaring will be indicated.

Best Buys are wines that offer a high level of quality in relation to price. There are no specific guidelines or formulae for determining Best Buys, but they are generally priced at $15 or less.

For the Trade

How to Submit Wines for Review

Wine Enthusiast Magazine tastes, rates and reviews wines, spirits and beers for publication in our Buying Guide, both in print and online. If you are interested in submitting samples for review and publication, please click here.


Photo: Jessica Miglio/Netflix

Netflix has added The Punisher to its long list of character-based Marvel shows joining Daredevil, Jessica Jones, Luke Cage, and Iron Fist, as well as the group show The Defenders. The Punisher, aka Frank Castle, who is a key character in the Daredevil series, is a bit of an anti-hero – a vigilante defending the murder of his family turned man-wronged by a shadowy CIA. Jon Bernthal, who played Shane on The Walking Dead, exhibits some Shane-esque characteristics here, conveying the tortured, unpredictable, two-sided Punisher.

There’s far less kung fu here in The Punisher, which may be a relief to those that really did not enjoy Iron First, and more traditional action storytelling with a hearty dose of violence. Bernthal doesn’t have any superpowers, like the mainthe Anvil recruiting program, he bonds with another support group member and they go canvassing in front of the Bronx County Courthouse in support of the Second Amendment. Later, Lewis learns from Curt that the guy he’s bonded with was never in Vietnam. Lewis confronts him and kills him.

The Bronx County Courthouse, part of the Grand Concourse, is another popular film location seen in shows like Gotham, Billions, Daredevil and more.

16. Newtown Creek

Photo: Nicole Rivelli/Netflix

Billy Russo meets Rawlins on the Queens side of Newtown Creek, which is on the border of Brooklyn. It is one of the most polluted waterways in New York City. It’s a popular film location due to the presence of Broadway Stages, a film studio in Greenpoint along the creek. In this shot, you


use the mapper tag
    <mapper type="glob" from="*.less" to="*"/>

in the foreach loop, like this:
<target name="build-in-loop">
  <foreach param="filename" absparam="absolute-filename" target="lessc">
    <fileset dir="${project.basedir}/assets/less/libraries/">
      <include name="*.less"/>
    </fileset>
  </foreach>
</target>

At this point, in the variable ${filename} in the target task there will be the filename without extension.

make use of this interest to woo people to the country."

"So we will use BIO 2007 as it gives a global platform to draw investor attention to Malaysia," he said.

Source: The Star Online

Posted by site editor
at 12:01 AM JST

Monday, 18 December 2006

FINAL PICK AT LAST MOMENTTopic: - Selection Process

By THE STAR

MOSCOW: The decision on which of the two Angkasawan candidates – Dr Sheikh Muszaphar Sheikh Shukor and Dr Faiz Khaleed – will go into space in October next year will be made at the last possible moment.

Science Technology and Innovation Minister Datuk Seri Dr Jamaludin Jarjis said although Dr Muszaphar was now considered the main candidate, this did not mean that he was going to be the one leaving for space on Oct 6.

Dr Faiz was currently the


training and when one of them was in space.

Meanwhile, Dr Faiz expected a lot of challenges in the final stretch and personally did not believe in anybody who said they were fearless.

"Everybody has fear. But it's how you conquer that fear. We have gone through a lot of training, we have to focus. In the army we have been taught how to conquer fear and believe in ourselves," said the 26-year-old dentist from Kuala Lumpur, who is attached with the Malaysian Defence Forces.

The Sept 2, 2007 date chosen to launch the first Malaysian astronaut into space is significant for several reasons.

It coincides with the country's 50th anniversary celebrations and marks 40 years of Malaysia-Russia relations as well as the 50th anniversary of the launching of Sputnik, the firstTHE TIMES/ AP

KUALA LUMPUR: An ethnic Indian female engineer lost her bid to become Malaysia's first astronaut Monday, as the government whittled the finalists to an army dentist and a hospital medical officer.

Prime Minister Abdullah Ahmad Badawi announced that either Faiz Khaleed, 26, or Sheikh Muszaphar Shukor, 34, will take part in a Russian space expedition next year - likely becoming the first Muslim to launch into orbit in more than two decades.

The announcement dashed the hopes of engineer S. Vanajah, 35, who made headlines in March when she was named the only woman among four finalists who outlasted 11,000 other Malaysians who applied for the astronaut selection process in 2003.

Vanajah, Faiz, Sheikh Muszaphar and Malaysia Airlines pilot Mohammed Faiz Kamaluddin were sent to Moscow's Russian Space Agency


examine the finalists' neurological fitness and ability to adapt to a weightless environment - will whittle their ranks to two candidates, each of whom will undergo 18 months of training at the Russian Space Agency.

But only one will have the chance to spend up to 10 days in October 2007 in a planned scientific expedition aboard the ISS, officials have said.

Officials have estimated Malaysia's space program will ultimately cost around US$25 million (euro20 million), but it will be offset as part of a US$900 million (euro750 million) defense deal struck with Moscow in 2003 to buy 18 Sukhoi Su-30 MKM fighter jets.vendor has closed a hole and I can't get in?

A:

Using PSExec to connect to an instance using the NT AUTHORITY\SYSTEM account:
http://www.mssqltips.com/sqlservertip/2682/recover-access-to-a-sql-server-instance/
However bear in mind that you may be breaking some contract, just wanted to note it :)
Original author is here


big, if we lead with courage, we can change the trajectory for millions from hopeless to boundless.”Kushner was cheered when he mentioned Trump’s decision last week to exit the Iran nuclear agreement. He also was cheered at the mention of the name of Vice President Mike Pence, new National Security Advisor John Bolton, and especially US Ambassador to the UN Nikki Haley.In his address, Israeli President Reuven Rivlin thanked Republicans and Democrats “for their love and support of Israel.“In every US election, every presidential candidate has promised to move the American Embassy to Jerusalem,” he said. “Finally, we have a leader who promised it and also kept his promise.And for this, we give thanks that we have arrived at this place at this time.“The Israeli people thank youman, or not sure?

"Your focus determines your reality." --Qui-Gon Jinn
"Reality leaves a lot to the imagination." --John Lennon
"Imagination will often carry us to worlds that never were. But without it we go nowhere." --Carl Sagan

Your very first post on this board, or rather the prior version of this board, was to express your hatred of Episode II and I as well. Now this one you say you need to see it again? Did you like it old man, or not sure?

I was definitely underwhelmed but I don't hate it either. I did love TFA, I left the theater filled with excitement and nostalgia all over again back in 2015. But this time I left...in want of something more. Like I said, I was underwhelmed. However I'm going to


your time.)

I haven't seen a new, or even recent, western since...I think it was The Quick and the Dead--and that was accidental: I was visiting the grandparents, and it was the only thing on the tube that evening. For me, the totality of the Western is pretty much one film, John Ford's The Searchers. I also liked Dances with Wolves, but it is, in addition to being silly if you think too much about it, also only tangentially a Western. Read the novel, too, which was significantly different. For one thing, the indians weren't Sioux but Comanche. But I ramble on...

Now you'll be gasping...I haven't seen The Searchers. I'll fix that, though. As you said, just a question of time. Now, I've heard some say Hostiles seemed influencedyour last movie then, gasp, you haven't seen The Last Jedi yet? (Now, I thought it stunk, but its more the idea that you haven't seen the latest SW yet. Take your time.)

That is correct. I await the disc. I have tried to avoid spoilers, but I've seen a few things and heard a few things... I think I know where it's going, and I'm not eager to get there. I'm thinking I'll probably be giving it a stunk minus.

Now you'll be gasping...I haven't seen The Searchers. I'll fix that, though. As you said, just a question of time. Now, I've heard some say Hostiles seemed influenced in some ways by The Searchers. Since I haven't seen it, can't comment on how accurate that is. But, I loved


not commissioned, rather the show ended with eleven stand-alone specials.

In North America, the show airs on TLC under the title My Big Fat Gypsy Wedding, with the original narration by Barbara Flynn replaced by Ellen K., while the TLC network started airing a spin-off featuring American Roma called My Big Fat American Gypsy Wedding.

Reception
The show has been criticised mainly by the Irish Traveller & British Gypsy/Traveller communities for misrepresenting them. Jane Jackson of the Rural Media Company (publishers the Travellers' Times) said:
Executive Producer Jes Wilkins said:
Billy Welch, a spokesman for Romani Gypsies, said:
During the episode No Place Like Home, Big Fat Gypsy Weddings had 4 of the top 10 trending topics worldwide on social networking website Twitter.

Television producer Simon Cowell expressed interest in makingto see mandated, then forget it. Life will simply get yet more complex and confusing for drivers – even if “drivers” is the wrong word to use for those sitting in the driving seat of self-driving cars.

Car owners is probably a more suitable word. And if your self-driving car is not insured when it causes an accident, it’s you as the owner that will be liable.

Fatal accidents on Britain’s roads rose 4% to 1,792 last year. That’s the highest level since 2011 and is clear evidence that fatal accidents are not falling despite all the chest beating of politicians about excessive speeds, and millions of pounds spent on speed cameras, speed awareness courses and traffic calming.

The DfT say the change in fatalities are not statistically significant, but even


1. Introduction
===============

Thanks to the rapid advances in the WSN domain (e.g., miniaturization of WSN nodes), Precision Agriculture (PA, also called precision farming in certain contexts) has started to emerge as a new trend in the agricultural sector in the past few years. Generally speaking, a PA system concentrates on providing ways for observing, assessing and controlling agricultural production processes, and covers a wide range of uses from herd management to field crop production \[[@B1-sensors-15-19507]\]. For example, the site-specific crop monitoring application involves numerous different issues. One of them is environmental data collection, such as monitoring soil, crop and climate in one/multiple fields, which are separated by parcels. Furthermore, a Decision Support System (DSS) can use these sensory data for promising treatments analysis of a whole field or aspecific parcel. Meanwhile, different actions can be carried out under the guidance of the analysis results and subsequent monitoring, for instance, adjusting in real-time operations such as fertilizer, lime and pesticide utilization, tillage, or sowing rate \[[@B2-sensors-15-19507]\].

PA and WSN applications combine an exciting new topic of research that will greatly improve quality in agricultural production, water management and at the same time will significantly reduce the cost and environmental impact of agricultural production. We note that a WSN is able to provide precise cultivated field information in real-time, and help reduce resource usage to minimize environmental pollution due to overuse of fertilizers, pesticides, *etc*. Furthermore, the open standardized protocols, the ease of deployment and system maintenance open a door to introduce the next generation of WSN---Internet of Things


as a complement to the application-specific routing requirements defined and analyzed by IETF ROLL WG, such as urban, industrial, home automation, and building automation LLNs. Advanced metering infrastructure (AMI) (or smart grid) documented and stated more exhaustively in \[[@B22-sensors-15-19507],[@B23-sensors-15-19507]\] has greatly inspired our work. Therefore, the work of this article is also a further extension of our previous work \[[@B20-sensors-15-19507]\].

3. IPv6 Routing Protocol for Low-Power and Lossy Networks: State-of-the-Art {#sec3-sensors-15-19507}
===========================================================================

RPL is a standard designed exclusively for routing in LLNs with the expectation of joining thousands of conventional WSN nodes in the network. It supports three traffic patterns: MP2P, P2MP and point-to-point (P2P). The basic idea of RPL is that the high degree of autonomy in the WSN nodes level through building a Destination Oriented DAGs (DODAGs) rooted towards       Packet reception ratio, BER, mean time between failures\... Link Quality Level (LQL); ETX
  **Link Color**                      10-bit encoded color to links, avoid or attract specific links/ traffic types

RPL is designed to be widely applicable, and it provides a set of available configuration options. The RPL specification \[[@B10-sensors-15-19507]\] presents a number of design choices and configuration parameters that are references to build a more efficient RPL implementation. In \[[@B29-sensors-15-19507]\], an overview and evaluation profile (*i.e*., two use cases: a small outdoor nodes deployment for building automation and a large-scale smart meter network) of RPL are presented. Furthermore, the above RPL implementations


of the designed protocol stack. The authors of \[[@B50-sensors-15-19507]\] mutually pool the entire protocol layers of a uIPv6 stack. This method is referred as "vertical calibration" in \[[@B51-sensors-15-19507]\] because their proposal strives to find the optimal settings from a global view of the protocol stack, namely from the application level to the MAC level. Moreover, the authors of \[[@B52-sensors-15-19507]\] adopt conventional cross-layer optimization, and propose stateless multicast RPL forwarding (SMRF) to improve "Multicast Forwarding Using Trickle". Meanwhile, as tight relations with adjacent layer, the researchers of \[[@B53-sensors-15-19507],[@B54-sensors-15-19507]\] present their contributions for RPL optimization dedicating to the interactions between routing layer and IEEE802.15.4 MAC standard. Furthermore, the utilization of cross-layer approach is not limited in the above scope. The authors of \[[@B27-sensors-15-19507],[@B30-sensors-15-19507]\] indicate that a cross-layer protocol combining MACcan be free of loops. In other words, the monotonic property could ensure network convergence for a routing algorithm. The isotonicity property essentially affects the order of the path weights and could guarantee the convergence is optimal for distance vector protocols like RPL. According to the work of Yang *et al.* in \[[@B67-sensors-15-19507],[@B68-sensors-15-19507]\], the primary routing metrics have been investigated and proved their monotonicity and strict isotonicity, which can insure the optimality, consistency and loop-freeness for any routing protocol type. Nevertheless, some other routing metrics have to be test carefully.

Gouda *et al.* take the lead in defining the lexicographic and additive routing metric compositions in \[[@B69-sensors-15-19507]\]. The lexical metric composition of two routing metrics $\left( {\text{S},\oplus,\text{ω}_{1}, \precsim_{1}} \right)$ and $\left( {\text{S},\oplus,\text{ω}_{2}, \precsim_{2}} \right)$ can be considered as the


considered firstly, but if only a few paths are under a defined low threshold, they will have more traffic load than the others. Thus, a combination of ETX and RE in a lexicographic manner cannot completely solve the hot spot problem but can mitigate the consequential network disconnection issue.

The basic purpose of energy-aware routing is to increase of the network lifetime \[[@B70-sensors-15-19507]\]. The RE indicating the lowest energy level in the path is concave and max-min criterion. If we define $\text{ω}\left( \text{α} \right)$ to reflect the RE of a link $\text{α}$, and $\mathcal{H}$ is the node set that constructs link $\text{α}$ and $\text{i}$ is an end node of this link, we can assume that $\text{ω}\left( \text{α} \right) = \text{min}\left\{ \text{RE}^{\text{i}} \middle| \text{~i} \in \mathcal{H} \right\}$ and $\text{RE}^{\text{i}} = \% of active nodes = 30% (min)   \% of living nodes = 0% (min)   \% of active nodes = 0% (min)
  **20 nodes**                                     +3.4                                                 +1.25


caused by the misbehaving nodes. Its packet loss increases very quickly if the number of misbehaving nodes is increased, and even though the ETX routing metric is able to alleviate the unreliable links its cumulative feature will still cause long-duration delays for carrying out these measurements. Thus, since RPL's MrhOF does not have any mechanisms to promptly detect the misbehaving nodes, more failed packet forwarding will happen, and the cost for the successful delivery of one data packet to the sink node is higher than in RPAL. In the composite routing metrics solution, the Link Color metric is able to reflect the robustness of the RPL router device and SCAOF sets this metric as a precondition when a node selects its parent. Misbehaving nodes can actively broadcast theirinstability may be unnecessarily induced in our static network, even hysteresis has been used to reduce churn in response to small ETX metric changes. Due to the existence of weight parameters in our RPAL model, the effect of hysteresis is magnified and this decreases the count of the switching parent. In addition, node 4 is used to be a key router in the 1st field test, and its unreliable characteristics will lead to more churns for its potential children (nodes 5, 6 and 10). Last but not least, it should be noticed that the RPAL model may also cause network churns due to its selection of a new routing path to avoid the battery depleting nodes. However, in our case, this impact is very limited and the evaluation


also notice that the network topology is not stable during the period when the battery-depleting nodes have up-and-down battery volume because they will become optional key routers along with the restoration of their batteries, and this enables them to be selected as preferred parents again.

7. Conclusions and Future Work {#sec7-sensors-15-19507}
==============================

ICT in agriculture needs the support of conventional WSN technology, and it is hoped that this work will become a driving force to push the use of WSNs in agriculture to the IoT. The A-LLN architecture for adapting the traditional WSN of Precision Agriculture (PA) applications to IPv6 LLN has been elaborated. Considering the ability to resist the highly dynamic environments in the real world, this work has focused on the energy optimization and the robustness of the wholeturning a blind eye to what Strauss was doing.

Since then, the powerful Republican congressman insisted repeatedly that he knew nothing about what Strauss was doing and had not even heard any locker room talk about the abuse.

After the Perkins Coie report was released, Jordan’s communications director insisted the report absolves Jordan.

“The investigators concluded what we have said from the beginning: Congressman Jordan never knew of any abuse, and if he had he would have dealt with it," Ian Fury said in a statement.

Jordan also told reporters on Capitol Hill the report “confirms everything I’ve said before. I didn’t know about anything. If I would’ve, I’d have done something.”

The Perkins Coie investigators, however, said in the report that "survivor accounts" and interviews with university staffers suggested that coaches knew.

“Many


and by mounting a new Si-CsI(Tl) hodoscope which provided good coverage of the solid-angle adjacent to the entrance of the spectrometer. In the data analysis, a consistent definition of the projectile-spectator source was adopted prior to comparing results from different reactions.

It was found that, within the realm of the present investigation, the universality of spectator fragmentation holds to very high accuracy. This includes the fragmentation of different projectiles if a linear scaling in proportion to their masses is applied to the data. In the following sections the experimental method and the obtained results will be presented in detail. The subsequent discussion will include comparisons to other data, some taken at much higher bombarding energies, and a search for related universal features within the intranuclear cascade and statistical multifragmentationthe projectile spectator. At 600 MeV per nucleon, this included six detectors, as illustrated in fig. \[hodoid\] (insert). They contributed about 10% of the fragment yield at this energy, mostly very light fragments with $Z$ = 3 and above.\
[**3.2 Charge correlations for $^{197}$Au + $^{197}$Au**]{}

With the definitions of the spectator source in rapidity and angle, as given in the previous section, the fragmentation patterns in $^{197}$Au on $^{197}$Au collisions were studied. Figure \[uniener\] shows the correlation between the mean multiplicity of intermediate-mass fragments $\langle M_{IMF} \rangle$ and $Z_{bound}$ for the four bombarding energies. Here intermediate-mass fragments (IMF’s) were selected according to the definition 3 $\le Z \le$ 30. The familiar rise and fall of the fragment production is seen to be independent of the projectile energy within the experimental accuracy.


not specifically demonstrated in fig. \[zdepen\], it is also valid for the mean multiplicities of the individual elements.\
[**3.3 Accuracy of mean fragment multiplicity**]{}

The attainment of a maximum of relative accuracy in the measurements at different bombarding energies was one of the motivations for adopting a common definition of the spectator source. The absolute accuracy of the measured fragment multiplicities and charge correlations is influenced by several experimental effects. They will be listed and discussed in the following where we will focus on the maximum value of the $\langle M_{IMF} \rangle$ versus $Z_{bound}$ correlation.

The upstream beam detectors, made of plastic scintillator foils with a resultant thickness of together 160 $\mu$m, represented a target of about 2$\cdot 10^{-3}$ interaction probability (not taking into account the hydrogen content). Coincident interactions of ano comparable decrease is observed at the largest particle multiplicities.\
[**3.5 Decay dynamics**]{}

The observed invariance of the transverse-momentum widths with respect to the bombarding energy (fig. \[transm\]) indicates that the entrance-channel dynamics play a minor role for the decay of the excited spectator. An estimate of the mean kinetic energies of the produced fragments in the moving frame was obtained in the following way: Event-by-event the vertical positions $r_{yi}$ of all fragments measured with the TOF wall were converted into transverse momenta $p_{yi}$ according to $$p_{yi} = (r_{yi}/L_i) \cdot A_i \cdot p_{P}/A_{P}
\label{EQ5}$$ Here the notation is the same as in eq. 1 with the additional subscript i denoting the fragment number within an event. With this information the center-of-mass motion of the decaying spectator in y direction and the intrinsic


$\langle E_x/A \rangle$ versus $A_0$ does not depend on whether $\Delta$ production is included or suppressed in the calculations (fig. \[cascade\], right-most panel). It does not respond to this modification of the heating mechanism. As outlined above, it is essentially the invariance of this function which is responsible for the observed $Z_{bound}$ universality. For the case of hadron induced reactions, this invariant feature has been known since the early intranuclear-cascade models were developed [@toneev].

The results of the calculations also exhibit the linear scaling with the projectile mass seen in the experiment (section 3.4). The slopes of $\langle E_x/A \rangle$ versus $A_0$ grow steeper with decreasing mass of the projectile but are the same when plotted versus $A_0/A_{P}$ (fig. \[inca0\]). This behavior is expected for the purely geometric abrasion. The intranuclear-cascadespectator. The corresponding lower limits are about 400, 800, and 1000 MeV per nucleon for collisions of gold projectiles with aluminum, carbon, and beryllium targets, respectively.

The results of calculations with the intranuclear cascade and statistical multifragmentation models permit a qualitative understanding of the observed universality. The calculations as well as comparisons with emulsion data for collisions at higher incident energies suggest that the identified production and fragmentation of excited spectator nuclei may persist up to very high energies with virtually invariant properties and slowly changing cross sections. In the pure abrasion picture, this follows from the mutual connection between excitation energy and cross section via their geometric dependence on the impact parameter. The additional mechanism of spectator heating by scattered nucleons or produced particles is not expected to


and V.D. Toneev, Interactions of high-energy particles and atomic nuclei with nuclei, Moscow, Atomizdat, 1972 (in Russian);\
V.D. Toneev, private communication (1994)

D.H.E. Gross, Rep. Prog. Phys.  53 (1990) 605;\
A.R. DeAngelis and D.H.E. Gross, Comput. Phys. Commun. 76 (1993) 113

W.A. Friedman, Phys. Rev. C42 (1990) 667

G. Papp and W. Nörenberg, preprint GSI-95-30 (1995)

W. Bauer, private communication (1991)

P. Désesquelles, J.P. Bondorf, I.N. Mishustin, and A.S. Botvina, Nucl. Phys. A, in print

P. Désesquelles, private communication (1996)

A.S. Botvina and Hongfei Xi, private communication (1996)

X. Campi, H. Krivine, and E. Plagnol, Phys. Rev. C50 (1994) R2680
his true passion is soccer. He began playing soccer at 5 years old, and every day, he wakes up thinking, “I want to play.” He went on to play varsity soccer for his high school, and became somewhat of an internet star when a video of one of his goals went viral.

It’s no wonder then, that the sports drink Powerade wanted to use Nico as the star of this commercial. The Calabria family idea that “you are not defined by the things you lack” exemplifies the sentiment behind the Power Through campaign. Whatever your condition, whatever obstacles you face, you can overcome. Nico will never play in the World Cup as an able-bodied player like he dreamed as a young child, but this commercial did air at the


important tool for the study of the interaction of the shock wave with dense concentrations of gas found in the ISM.

The Galactic SNR G 32.8–0.1 (Kes78) was discovered in a 408 MHz radio continuum survey by Kesteven ([@kes68]), where it appears as a small source (20$\times$ 10 in diameter). Several radio observations were perfromed eversince at 30.9, 330, 408, 430, 2700, 5000, 10600 MHz by Kassim ([@kas89]), Kassim ([@kas92]), Caswell et al. ([@cas75]), Dickel & Denoyer ([@dic75]), Velusamu & Kundu ([@vel74]), Caswell et al. ([@cas75]) and Beckel & Kundu ([@bec75]) showing its non–thermal emission, while a spectral index between 0.5 and 0.78 was established. Observations in the hydroxyl molecule (OH) at 1720 MHz (Koralesky et al. [@kor98]) showed that the emission results from masers that are shock–excited due toA**IRN**I12 (20.7)*dhps* (n = 30) Wild-type haplotype SAKAA4 (13.3) Single mutant haplotype S**G**KAA18 (60.0) Double mutant haplotype **AG**KAA8 (26.7)*pfcrt* (n = 36) Wild-type haplotype CVMNK4 (11.1) Mutant haplotype CVIET32 (88.9)*pfmdr1* (n = 54) Wild-type haplotype, NYSND19 (35.2) Single mutant haplotype, **Y**YSND26 (48.1) Single mutant haplotype, N**F**SND6 (11.1) Double mutant haplotype, **YF**SND2 (3.7) Double mutant haplotype, **Y**YSN**Y**1 (1.8)For each haplotype, mutant alleles are in bold.

In a study on 21 isolates collected in Huambo, a neighbouring province to the east of Benguela province, all carried the mutant Asn-108 *pfdhfr* allele, and the double mutant haplotype Ile-51/Asn-108 was the most prevalent \[[@CR24]\]. Overall, in that study, 25% of the isolates collected from different localities in the country presented the triple *pfdhfr* mutant alleles. In another study on isolates collected in Luanda \[[@CR25]\], 31 of 61 (51%) samples were triple *pfdhfr* mutants, and 25 of 61 (41%) and


a large majority (88.9%) were characterized by the mutant haplotype CVIET. The other isolates were of wild-type haplotype CVMNK. Ser-72 was not found in the present study.

In one of the studies conducted in Luanda in which only codon 76 was determined, Thr-76 was found in 230 of 241 (94%) isolates \[[@CR27]\]. In the second study in Luanda, the mutant *pfcrt* haplotypes included the South American-type SVMNT (58 of 102, 57%), CVIET (13 of 102, 13%), and minor and mixed haplotypes \[[@CR28]\]. The *pfcrt* SVMNT haplotype has been rarely reported from the African continent. This haplotype is more commonly found in South America and in some Asian countries and is associated with resistance to amodiaquine and chloroquine \[[@CR29]\]. It has been hypothesized that the unusual predominance of SVMNT inhigh prevalence of chloroquine-resistant *P. falciparum* in Angola.

Of 54 isolates analysed in the present study, most (29 of 54, 53.7%) carried the mutant *pfmdr1* allele Tyr-86, but mutations occurred less frequently in codons 184 (8 of 54, 14.8%) and 1246 (1 of 54, 1.9%). All isolates had the wild-type Ser-1034 and Asn-1042 *pfmdr1* codons.

In an early study, of 15 Angolan *P. falciparum* isolates (11 chloroquine-resistant and 4 chloroquine-sensitive in vitro), the majority (73%) of chloroquine-resistant isolates carried the mutant Tyr-86 \[[@CR31]\]. In Luanda, pure Tyr-86 allele and Tyr- and Asn-86 mixed alleles were found in 142 of 199 (71%) isolates \[[@CR27]\]. In the northern province of Uige, many isolates (45 of 66, including mixed Asn- and Tyr-86; 68%) also had the mutant Tyr-86 \[[@CR26]\]. However, in Bengo province,


The human MTHFR rs4846049 polymorphism increases coronary heart disease risk through modifying miRNA binding.
Abnormal functioning of 5,10-methylenetetrahydrofolate reductase (MTHFR) enhances the risk for coronary heart disease (CHD). Here, we tested whether a single-nucleotide polymorphism (SNP) located in the 3' untranslated region (UTR) of MTHFR was associated with CHD susceptibility by affecting microRNAs binding. We first analyzed in silico the SNPs localized in the 3' UTR of MTHFR for their ability to modify miRNA binding. We observed that rs4846049 (G > T) was a potential candidate SNP to modulate miRNAs:MTHFR mRNA complex, with the greatest changed binding free energy for has-miR-149. Based on luciferase analysis, hsa-miR-149 inhibited the activity of the reporter vector carrying -T allele, but not -G allele. We further conducted a case-control study (654 vs 455)at sporting events.

But as productive as their stunt at the World Series has been, the daring move almost never came to be.

The trio uploaded a video to the Shagmag YouTube channel detailing their plans to pull off the stunt with the video beginning 48 hours before their tops were raised. Two incidents almost saw it all fall apart.

It all begins with Rose sitting in front of a computer on the phone to her credit card company attempting to have a “pretty big” transaction completed.

The purchase in question were tickets to Game 5 at Nationals Park. Celebrations erupt when the purchase finally goes through. “We’re going to flash our t*** at the World Series,” Rose shouts.

READ: Why we flashed at the World Series

Rose purchased the three tickets to the


Unbelievably adorable plush Eevee!

Returning home from work today I found a lovely little package waiting for me. Inside was a darling custom-made plush Eevee; my favorite Pokemon! I still can't believe how freakin' cute this thing is! It's very well-made, with good stitching and nice felt.

I have a lot of Pokemon plush toys, but nothing so sweetly custom-made. It's new home is on my "stuffed animal corner" in my living room, next to its Eeveelution brethren.

Thank you so much, Pokematch! Your kind gift has made me very happy! :Dmechanism in order to not overwhelm elasticsearch. Another approach would be to send events to another app (e.g. logstash etc), so the throttling and persistence will be handled by that system and not your application.
Another approach would be this https://www.elastic.co/blog/logstash-jdbc-input-plugin. You use another system that "polls" your database and sends the changes to elasticsearch. In this case logstash is ideal since it's part of the ELK stack and it has a great integration. Check this too https://www.elastic.co/guide/en/logstash/current/plugins-inputs-jdbc.html
Another approach is to use the NOTIFY mechanism of postgres to send events to some queue that will handle saving the changes in elasticsearch.


reason I don't buy
baby carrots anymore: they're slimy.

I have no idea why but a couple of years back the carrots started getting
slimy and it got progressively worse.

Now, instead of eating a bunch of baby carrots as a snack I just take a whole
carrot and cut it into quarters lengthwise and eat that.

~~~
oihujyfgthyjuik
When they were a luxury food the baby carrots were actually 'young' carrots.

Now they are popular they are just sections of whole carrots put through a
press to cut and shape them. They are basically carrot 'french fries' thats
why the end up slimy

had no end of customer service problems with UPC
#ubuntu-ie 2010-12-10
<emboss> ebel: Recently?
<ebel> emboss: *read scrollback* No not recently. circa 2 years ago NTL problem
<emboss> I've just spent most of the morning on to them, really is a painful exirience
<ebel> emboss: they are liars IME. Go to comreg.
<ebel> Don't deal with UPC. Deal wit Comreg. Your problems will get fixed
<davem> does anyone homebrew? and if so where do you get your stuff from?
<terran> davem: http://www.thehomebrewcompany.ie/
<davem> you used them? I've found a few websites and want to know if they're any way good at all
<emboss> davem: I used too, I got all my stuff from here, very helpful and friendly http://www.grapengraindublin.com/
<emboss> I went physically to the shop tho
<davem> where is the shop? I can't find anything on their website about


|| Ubuntu Hours: No Ubuntu Hours for December.
#ubuntu-ie 2011-12-05
<tdr112> can you find out who made you hard dirve using a command
<ebel> tdr112: parted?
<ebel> "sudo parted /dev/sda print" should give model number. Googles from there
<tdr112> thanks ebel
<airurando> printer question
<airurando> my sister has a samsung CLP-320 colour laser printer.
<airurando> I installed the samsung unified driver as detailed in the following forum entry
<airurando> http://ubuntuforums.org/showthread.php?t=341621
<airurando> test page looked great.
<airurando> printing from open office and libre office the top margin is very slim
<airurando> anyone know how to modify this?
<slashtommy> is it set for A4 or Letter?
<slashtommy> these things tend to default to Letter, so check the printer (driver) settings and open office settings
<airurando> definately set for A4
<airurando> oh at least printer settings
<slashtommy> in which?
<airurando> printer settings
<slashtommy> what about open office settings?
<airurando> not sure
<airurando>we can only get past the dublin accents! :-D
<airurando> a wiki is involved
<airurando> my daughter Orla doesn't have a dub accent!
<airurando> ding pics to the wiki was interesting
<airurando> *uploading
<airurando> loads of licensing options
<airurando> including all the cc
 * airurando haad a very interesting discussion with orla about the licensing options
<moylan> well she can learn a valuable lesson today.  even zuckerburgs private images were leaked.  what goes on the internet stays on the internet.  http://news.ycombinator.com/item?id=3318652
<airurando> I chatted with her about http://creativecommons.org/licenses/
<airurando> made some heradway
<airurando> brought it to the attention of her teacher
<airurando> was met by a blank face....
<moylan> now THAT is useful.  if the teacher listens that is...
<airurando> sent a hardcopy of the page to the teacher
<airurando> but fear it was ignored
<airurando> the project is


run through NUI maynooth
<moylan> there was great article recently about an american school that saved a few thousand dollars by creating its own school books.
<airurando> yeah?
<moylan> well the price of school books is silly.  and they are changed minutely every 2-3 years so that used ones lose their resale value
<airurando> 2-3 years? 2-3 mins in my opinion
<airurando> I hear ya
<moylan> and stick an electronic version on a â¬100 ebook reader with e-ink and save the kids a hernia
<airurando> you speak logic
<airurando> but logic currently does not prevail
<moylan> the problem is they are using logic to fix a human problem.  they need to use bribery.  ie. any budget saved on books goes to teachers resources in class.
<moylan> make a teachers job easier and they are motivatedwas significant for heterophil-to-lymphocyte ratio (P<0.05), differences between cold-stressed and control birds being significant in 2 breeds. In these breeds (Red-Barred Vasca and Buff Prat), heterophil-to-lymphocyte ratio was significantly greater in cold-stressed birds. Cold stress effect was significant for the relative asymmetry of toe length (P<0.001) and the combined relative asymmetry (P<0.05), the relative asymmetry of birds with cold stress being larger than that of control birds. Thus, cold stress seriously negatively affects the welfare of cocks.


pitstop.

It allowed Jamie Whincup - who had done remarkably well himself to get into the lead from 23rd on the grid - and Mark Winterbottom to speed away, only for Winterbottom to spin out soon after.

The race became a shoot-out between Whincup and Mostert, with Whincup desperately trying to manage his fuel with an increasingly quick Mostert breathing down his neck.

Ultimately, Mostert's extra fuel gave him the late burst he needed as Whincup looked to coast down the hill in the final lap.

Mostert found the gap he needed, speeding away from Whincup with half a lap to go to take out the title.

Whincup, who ultimately finished fifth, watched on as Moffat and Percat beat him to a podium finish.

"The lights went out and I dropped, while everyone elsetwo patients. Octreotide scintigraphy was performed in 14 patients and femoral angiography was performed in 27 patients. Multicentric disease was present in one patient and one patient had bilateral involvement. Transcervical excision was the most common approach. Complications were as follows: transient facial nerve paresis (n=3), vagal nerve palsy (n=2), hypoglossal nerve palsy (n=2), permanent facial paralysis (n=1), bleeding (n=1), and total hearing loss (n=1). No recurrences were encountered during a mean follow-up of 71 months. Preoperative evaluation of all patients with respect to catecholamine secretion and multicentric disease is important for choosing the proper treatment and preventing possible complications.


0.5

Token::BOOLEAN_TYPE special symbols like "true" and "false"; the exact details can be configured in TextInput::Settings

Token::LINE_COMMENT_TYPE (disabled by default); generated for line comments as specified by TextInput::Settings

Token::BLOCK_COMMENT_TYPE (disabled by default); generated for c-style block comments as specified by TextInput::Settings

Token::NEWLINE_TYPE (disabled by default); generated for any of "\\r", "\\n" or "\\r\\n"

The special ".." and "..." tokens are always recognized in
 addition to normal C++ operators. Additional tokens can be made
 available by changing the Settings.

 Negative numbers are handled specially because of the ambiguity between unary minus and negative numbers--
 see the note on TextInput::read.

  TextInput does not have helper functions for types with non-obvious
  formatting, or helpers that would be redundant.  Use the serialize
 escaped and is not
            treated as a comment character.

            Default is '\\0'.
         */
        char                otherCommentCharacter;

        /** Another (optional) 1-comment character.  Useful for files that
            support multiple comment syntaxes.  Default is '\\0'.
         */
        char


    like "nan" are to be used; these are supported by
          G3D::TextInput::Settings::simpleFloatSpecials.

          An alternative to specifying msvcFloatSpecials is to read numbers as:
          <pre>
            Token x = t.read();
            Token y = t.peek();
            if ((x.string() == "-1.") &&
                (y.string() == "#INF00") &&
         /** All symbols that will become the 'true' boolean token.  See also caseSensitive.
            Clear this value to disable parsing of true booleans.

            Default is {true}.
         */
        Set<std::string>    trueSymbols;

        /** See trueSymbols. Default is {false}*/
        Set<std::string>    falseSymbols;

        Settings();
    };

private:

    std::deque<Token>       stack;

    /**
     Characters


 /**
     Read the next token, returning an END token if no more input is
     available.
     */
    Token nextToken();

    /**
       Helper for nextToken.  Appends characters to t._string until the end
       delimiter is reached.

       When called, the next character in the input buffer should be first the
       first character after the opening delimiter character.
    */
    void parseQuotedString(unsigned char delimiter, Token& t);

public:

    class TokenException : public ParseError {
          input.  In that case, typically error reporting related to the token
        is only going to occur because of a mismatch, so no location
        information is needed by the caller.

        WrongTokenType will be thrown if the next token in the input stream
        is not a string.  WrongString will be thrown if the next token in the
        input stream is a string but does not match the @p s parameter.  When
        an exception is thrown, no tokens are


the @e next token.  See also peek.  */
    int peekLineNumber();

    /** Returns the character number (relative to the line) for the @e next
        token in the input stream.  See also peek.
    */
    int peekCharacterNumber();

    /** Take a previously read token and push it back at the front of the
        input stream.

        Can be used in the case where more than one token of read-ahead is
        needed (i.e., when peek doesn't suffice).
    */
    void push(const Token& t);

constipated and gave the baby milk of magnesia instead of consulting with a doctor, says Burnstine, who adds that he never recommends baby nurses.

"Certainly it helps mothers to get rest, and if these people are going to take care of the minute-to-minute care particularly during the night, that's a good thing," he says. "But that's it."

Susan Smartt, a postpartum doula with Birthways in Illinois, majored in English literature in college and worked with teenage mothers through community service organizations after graduating. She took Birthways' week-long training course and while she admits she isn't offering medical services, she's learned enough to determine whether something the baby is doing is normal or whether they should see a doctor.

"A doula is not a medical care provider, but we can help to


this WMG, and I endorse it anyway because it's frickin hawt.

How many girls named Kain have you heard of? Cindy McKain. Please explain this one. Plus the OP said "bi" not "lesbian". Maybe she liked Kain (a boy) and then got interested in Winry (a girl)...

Maybe she likes Ed AND Winry?

The part about the word in the manga is true: 恋人 (koibito) is gender-neutral. And the manga never mentions a name or any other definition either. The only other word they use (as far as I noticed) was あの人 "anohito" but that's gender-neutral too. (On the other hand, it's fairly usual in Japan. There's nothing particularly strange about the gender-neutral wording unlike in English where you kind of start to suspect something if people are avoiding gendered words.phrase), but like Strongine. She looks like transvestite!Alex. So does his other sister, Amue. Havoc's hormones did an about face when he saw Catherine. :)

Alternatively the Twilight vampires are distant relatives of the Armstrong family-as in at least Carslie Cullen's era. The Armstrong family may have been awesome for generations, but that doesn't mean they've been awesome for every generation.

Major Armstrong's claim that he uses techniques "passed down the Armstrong line for generations" is a lie. He's merely an immortal who continuously uses the same techniques despite changing identities to keep people from being suspicious of his true nature, and merely claims that they've been passed down to him in case anyone notices the fact that his techniques are the same as his supposed "ancestors". This also explains


I'm not sure it would count as human transmutation. This seems more like creative arrangement. Remember when Ed (in the anime at least) turns his hair green? He was just using a way to make the pigments cover his hair without waiting half an hour, like we normally do. Even then, with human transmutation, doesn't the alchemist need to find a way to combine all the different materials cohesively? In the case of an embryo or fetus, all the chemicals and pieces are there, so wouldn't it just be a simple matter of rearranging the DNA?

"These genetic engineering techniques have been passed down the Armstrong line for generations!"

Then wait a second, what about the two sisters who look like Alex?

Maybe they thought that they would be male, sobe done with it. But the reason that tipped the scales, the reason that Roy didn't let Riza shoot him, was not his goal at the end. At the end it was an unwillingness to cause Riza pain again. Despite Scar and Ed's words' affecting him, up until Riza told him she'd die too, Roy was willing to die. - and now I've rambled on again, so I don't really know if you got my point, but here it is: Roy and Riza care about each other more than themselves. I'm not saying it's nice, I'm not even saying it's healthy- however, I don't believe that you can care that much about a person on a platonic level. Not to mention Arakawa herself has dropped little hints various


I also apologise for the lateness, real life has been nailing my ass. Point 1) I think we might just have to disagree on this, especially when you state what Arakawa planned and wanted. Neither of us are Arakawa, and neither of us can talk on her behalf. I just can't get over Riza asking Roy to burn her, considering the symbolism involved and the frequent references on how burning people has given Roy a sinister edge. Maybe it's just me. Point 2) Thing is, Roy did willingly commit genocide. As Riza says, the homonculi started it but they carried it out. Kimblee's scene in the flashback is all about making Roy and Riza take responsibility for what they've done instead of thinking that they 'had' to. Sostuff in his mouth or the dissolution cannon, where it's dumped into a giant Garbage Bin of Infinite Holding. Not that it really changes anything.

If Mustang had found out that Envy started the Ishvalan War

there wouldn't have been time for anyone to step in and stop the Roaring Rampage of Revenge. Not that Riza probably would've tried had she known that.

May's clan is evil

I don't know about them specifically, but there's definite evidence that the Xingese court might be a Deadly and Decadent one. Once they have learned how a philosopher's stone is made, one of the Xingese characters (I believe May herself) notes their discomfort at going back to Xing with this information, because they know the response would be "Great, now let's just round up a