Introduction {#sec1-1}
============

Assessment is an essential and integral part of medical education. It enables us to decide how much the trainees have learned and whether they have achieved the required standards. Nowadays, with the development of competency-based curriculums, it is expected that competency-based assessment methods will be considered in medical education too, and therefore, the methods associated with the levels of "shows how" and "does" of the Miller Pyramid are considered in the student assessments ([@ref1]-[@ref3]). Using assessment methods which evaluate competence and also real performance are highly recommended ([@ref3]-[@ref7]). Several studies have shown that in order to accept a certain assessment method widely, it should be valid, reliable, replicable and practical with positive impact on the students' learning ([@ref1]-[@ref3]). Knowledge and competence assessment tests are reliable teats, butappropriate assessment methods will be inevitable. In other words, just because a trainee has passed the Cardiopulmonary Resuscitation (CPR) course and successfully passed a multiple choice theory exam and an Objective Structured Clinical Examination (OSCE) on a model, it does not essentially mean that he would be successful and effective when encountering a patient with true cardiac arrest. Therefore, workplace based assessment should be taken seriously even during medical school and this is not unique to the postgraduate but of course for everybody who will provide care in the future. Congruence between the aims of education and the methods of evaluation is necessary. Neither the knowledge assessment test nor the competence assessment test can reliably predict the actual performance of a doctor in the future. DOPS is seen


Drop the other end of the rope to the ground to avoid another trip to the roof to retrieve it. If the rope isn't too short and you do it right, when he's gone, you should be able to pull the rope out of the fireplace without getting back on the roof. You also need to get a screened flue cap for your chimney, as it's about the best way to keep this problem from reoccurring. If the flyer has a means of exit, it is possible to drive it out with Obnoxious Technigues. Damper MUST BE CLOSED. Place a small stool in the fireplace with an open bowl on it. Fill the bowl with ammonia. Also place a radio in the fire place and tune it toPakistan region,” Trump said in a statement. However, the US President did not specify the...

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Rasgovindpur: A lecturer of a college in Mayurbhanj district was arrested Saturday on charges of misbehaving with a tribal girl student at Rasgovindpur block here. The accused has been identified as Siba Prasad Khatual, lecturer of education department of the college. In her complaint, the girl alleged that the lecturer misbehaved with her during a class Thursday....

Ayodhya: Senior BJP leader Subramanium Swamy has claimed that the construction of the grand Ram temple in Ayodhya will commence by November. He also stated that the decision of the Supreme Court, which is hearing the Ram Janambhoomi-Babri Masjid title suit, will be in favour of the Ram temple. Swamy, who was in Ayodhya on a


Studies on the subcommissural organ of Salmo gairdneri.
The light microscopic analysis of serial sections of the subcommissural organ (SCO) of the rainbow trout (Salmo gairdneri) shows that the form of the groove-like (in cross section) organ varies over its total length. Its rostral origin is a tunnel-like structure anterior to the orifice of the hollow pineal stalk. The SCO forms the dorsal wall of the brain. Caudally the SCO is increasingly displaced from the surface of the brain by the fibers of the posterior commissure; the organ ends in a tabular area beyond the latter. The orifice of the pineal stalk is surrounded by the ependyma of the SCO that invaginates like a funnel and joins with the ependyma of the pineal stalk after a considerable narrowing. Therudimentary parapineal organ is located on the left side of the brain and is connected with the left habenular ganglion through the parapineal tract. It contacts the third ventricle with a short channel within the ependyma of the SCO. The histological organization of the ependymal and hypendymal cells of the SCO is typical of teleosts. Secretory material is located basally and apically in relation to the nucleus, but there is no indication of a basal secretory release. Basal ependymal processes terminate with broadened endings at the membrana limitans externa. The apical product is discharged into the third ventricle, where it aggregates into the thread-like structure of Reissner's fibre. The SCO cells have no direct contact with cerebral or meningeal blood vessels.


tally on the boards was a staggering 48-28 in favor of Toronto. While Denver’s players fought hard and battled it seemed they were just met head-on by their own limitations.

Fatigue may have been a factor as well, with the Nuggets playing their fourth game in a row on consecutive nights. After six days of action, tired legs were showing up for nearly every summer league team but rookie Erick Green denied that it was a determining factor in the loss.

“I don’t think we’re wearing down. We’re just not doing the little things. Not getting back on D, not rebounding well. We’re taking too many threes and it’s the little things we’re not doing that are keeping us from winning” said Green.

Green has been really tough on himself inroll coverage,” Conner said. “We had different coverages with the big guys, the fours and fives, plugging where they were letting [ballhandlers] come against the grain and get all the way to the rim. They weren’t impacting the basketball so that’ll be something we clean up tomorrow.”

Odom and Green forming a bond

DJ Odom has been one of the better point guards on the roster, looking the part of a veteran who plays solid D and knows how to make plays in transition. Another thing the second-year guard can add to his impressive resume: leadership. Rookie Erick Green told me after the game how Odom has been mentoring him and helping him adjust to the higher level of competition.

“I’m trying to learn. DJ has been a good role model


out Hamilton as the one youngster he perhaps didn’t do a great job with, as Jordan is now heading into his third season still waiting for a meaningful opportunity to prove himself and earn minutes.

After spending his first two seasons seemingly buried in Karl’s doghouse, you might expect Jordan to be frustrated with the relationship. As a matter of fact, Jordan praised Karl for aiding his development and denied any communication issues with the former head coach.

“I know he emphasized me being a young player. He always used to say I’m really supposed to be in my senior year of college, so that’s how I knew he prides himself on being harsh to young guys. But it was a good thing because I’ve learned a lot from coachThe present invention relates to a vehicle anti-theft apparatus that uses vehicle position information.
Japanese Laid-Open Patent Publication No. 11-091510 describes a conventional immobilizer system. The immobilizer system includes a transponder, which is incorporated in a portable device such as an ignition key, and an anti-theft apparatus, which is installed in a vehicle.
In the prior art, the ignition key is inserted in a key cylinder of a vehicle and turned to an ignition position. As a result, the anti-theft apparatus supplies the transponder with electromagnetic energy through radio waves, that is, in a non-contact manner. The transponder, which is activated by the electromagnetic energy, then transmits an ID code, which is stored in the key, as a radio wave having a predetermined frequency. An ID code is registered in


Let me start with the punchline: if you are interested in 47 USC 230 jurisprudence (and let’s face it, who isn’t???), then you need to read this article. In fact, clear your calendar for this afternoon. Although I am not completely sold on its conclusions, any cogent discussion about 47 USC 230 jurisprudential trendlines must acknowledge this article.

David Ardia directs the Citizen Media Law Project, a frequent outlink on this blog. He undertook the heroic (and some might say ill-advised) task of finding and coding 47 USC 230 cases–a total of 184 decisions–and then generating some statistical conclusions from the dataset. This is not a project I would have undertaken because empirical research is such a quagmire, but we as a community of 47 USC 230 scholars andhave faced eventual liability under the common law because they lacked knowledge of and editorial control over the third-party content at issue in the cases. Given this prediction, one might question whether section 230 is necessary.”

Whoa! This is an important and implicitly troubling statement. The paper is positing an alternative scenario where 230 doesn’t exist and arguing that we might not notice a difference. Of course, we know that other countries are having very different experiences with UGC due to the 230’s absence. At the same time, US common law still differs from other countries’ laws, so perhaps the US common law’s trajectory would have reached a similar place. Having said that, for reasons the paper does explore, we are better off for having the statutory immunity than


52 B.R. 175 (1985)
In re The FRY BROS. COMPANY, EIN # XX-XXXXXXX, Debtor.
Arthur FRY, Jr., Trustee, Movant,
v.
FRY BROTHERS COMPANY, Respondent.
Related Case No. 1-84-00791.
United States Bankruptcy Court, S.D. Ohio, W.D.
July 26, 1985.
Robert A. Goering, Cincinnati, Ohio, for movant.
Paul A. Nemann, Cincinnati, Ohio, for Creditors' Committee.
George K. Fogg, Cincinnati, Ohio, for debtor.

*176 DECISION ON MOTION FOR RELIEF FROM STAY
BURTON PERLMAN, Bankruptcy Judge.
Movant herein, Arthur Fry, Jr., Trustee, here moves for relief from the § 362 automatic stay which arose by operation of law upon the filing of the underlying bankruptcy case. Fry says that he holds three notes totalling $150,000.00 which are the subject of a security agreement between Fry and debtor. Real estate located at 3600 Cardiff Avenue comprises a portion of Fry's collateral, and in addition he isto organize how work should be split among willing people in this post, as it's much better discussed live, on the IRC/Discord channel linked above - and that's what I'd like to focus on during the next few days.

Follow-up

I will write more on the topic in 48 hours from now. (lonjil, prepare your killswitch.)


focused on the remaining HSC compartment and were able to carry out detailed analysis by pooling BM from four to five recipient mice per time point. Evaluation of primitive cell marker expression in the human lin^−^ compartment revealed that the loss of human 126/OE cells in transplanted mice was not due to a decrease in the CD34^+^CD38^−^CD90^+^ stem cell compartment size ([Figure 4](#fig4){ref-type="fig"}B). On the contrary, we observed, on average, a 2.5-fold increase in the phenotypic CD34^+^CD38^−^CD90^+^ stem cell compartment for 12 weeks posttransplant, after which marked primitive cells were no longer recoverable ([Figure 4](#fig4){ref-type="fig"}C). In addition, cell-cycle analysis of HSC-enriched Lin^−^CD34^+^CD38^−^CD90^+^ cells with 126/OE in the xenografted BM over time showed a consistently higher percentage of cells in G~0~ (Ki67^−^; [Figures 4](#fig4){ref-type="fig"}B and 4D). These data indicate that miR-126 negativelylist 1, p = 0.0003), indicating that this may be the primary pathway under the influence of miR-126 in primitive lin− CB cells. In this pathway, PIK3R2, ITGA6, and ILK, all predicted miR-126 targets, are upregulated upon 126/KD and downregulated upon 126/OE. As the effect of miRNA modulation of gene expression may be stronger at the protein level, and to provide another unbiased approach, we performed a quantitative analysis on the proteome of K562 cells stably transduced with 126/OE or CTRL vectors by using the stable isotope labeling of amino acids in culture (SILAC) technique ([Figures S5](#app2){ref-type="sec"}A--S5C). Interrogation of this data set by using unsupervised Ingenuity Pathway Analysis (IPA) found that, upon 126/OE, the PI3K/AKT signaling pathway was among the most significantly affected canonical pathways ([Figures S5](#app2){ref-type="sec"}B and S5C),


of miR-126 targets in hematopoietic stem versus progenitor cells.

This report links a miRNA to the regulation of human HSC, thus opening an avenue to develop therapeutic strategies for human HSC maintenance and expansion. There is great need to understand how HSC are regulated in order to take a more rational approach to harness human HSC for clinical purposes. The discovery that miRNAs occupy a central regulatory role opens an alternative avenue to manipulate HSC quiescence and cell-cycle entry with the ultimate goal of HSC expansion for clinically important therapies. The significant expansion of long-term HSC, here induced through the manipulation of the miR-126/PI3K/AKT signaling axis, supports the plausibility of this approach. It is conceivable that manipulation of miR regulation may provide a more physiological approach to fine-tune a cellularthe right femur of each recipient mouse. After euthanizing the mice, bone marrow cells were flushed with 2 ml PBS 2% FCS, and 50 μl was stained for surface markers. Remaining cells were lineage depleted and/or used for additional surface or intracellular antigen staining. For lineage depletion, BM cells flushed from the femurs and tibias of three to five mice (\>3% human cells) were combined and processed with the StemSep Mouse/Human Chimera Enrichment Kit (Stem Cell Technologies) according to the manufacturer's instructions. However, during the antibiotin incubation step, an additional 50 μL/ml human hematopoietic progenitor enrichment antibody cocktail from the StemSep Human Progenitor Cell Enrichment Kit was added to deplete human-lineage-positive cells.

Isolation and Transduction of Murine HSPC and Bone Marrow Transplants {#sec4.3}
---------------------------------------------------------------------

Donor mice between 6 and 8 weeks of age were euthanized


cells over CTRL (dotted lines) and its abrogation upon single-dose administration of 10 μM Ly (solid lines). Right, fold change in cell numbers of 126/KD normalized to CTRL cells, treated (black) or not (red) with Ly. Results are shown as min/max box and whiskers plots of n = 5 independent experiments. ^∗^p \< 0.05 and ^∗∗^p \< 0.01.](gr6){#fig6}

[^1]: These authors contributed equally to this work

[^2]: Co-senior authors
the Itô integral, there have been many approaches to extend stochastic integration for integrand and integrator processes which are not covered by the classical theory. Forward integration is a natural generalization of Itô integration allowing for anticipating integrands and for more general integrator processes. There are basically two approaches in order to define a forward integral with respect to Brownian motion: by means of Wiener analysis (and/or white noise analysis) as done in [@BM82; @NP88; @KR88; @AP91] and by regularization techniques first introduced in [@RV93]. The Brownian forward integral allows for anticipating integrands, is well approximated by forward Riemann sums and is linear when the integrand is a constant random variable.\
\
The regularization technique developed by F. Russo and P. Vallois in [@RV93] is an almost pathwise method allowing


compared with Theorem $2$ of Section $8$ in [@MR2374640] where a similar result is obtained under the assumption of existences of the trace terms. The author use the representation of the Rosenblatt process on a compact interval and the Malliavin calculus with respect to Brownian motion whereas we use its representation as a double Wiener integral on $\mathbb{R}^2$ and stochastic gradient operators on the white noise space.

-   As a straightforward corollary, we have the following new Itô formula: $$\begin{aligned}
    F(X^H_b)-F(X^H_a)&=d(H)\big(\nabla^{(2)}\big)^*\bigg(\int_a^b F'(X^H_t)\dfrac{(t-.)^{\frac{H}{2}-1}_+(t-\#)^{\frac{H}{2}-1}_+}{\Gamma(\frac{H}{2})^2}dt\bigg)\\
    &+B(H)\nabla^*\bigg(\int_a^b F''(X^H_t)(t-.)^{\frac{H}{2}-1}_+I_1(l^H_{t,t})dt\bigg)+H\int_{a}^bt^{2H-1}F''(X^H_t)dt\\
    &+\frac{H}{2}\kappa_3(X^H_1)\int_a^bt^{3H-1}F^{(3)}(X^H_t)dt+C(H)\int_a^bI_2(e^H_{t,t})F^{(3)}(X^H_t)dt.\end{aligned}$$

-   The previous Itô formula should be compared with Theorem $3.16$ of [@A15] where we obtain an Itô formula in the white noise sense for entire analytic functionals with growth conditions ofthe Rosenblatt process. The link between theses two formulae can be made by using iterated integration by parts on the white noise space thanks to the pointwise multiplications with $I_1(l^H_{t,t})$ and $I_2(e^H_{t,t})$ for smooth enough functionals.

Organisation {#organisation .unnumbered}
------------

This paper is organized as follows. In the first section, we introduce the relevant tools from Hida distribution theory and we define the Sobolev-Watanabe-Kree spaces on the white noise space. In the second section, we define the fractional and the Rosenblatt noises, the stochastic integrals with respect to them and the associated stochastic gradient operators. In the third section, we start by analyzing the fractional brownian motion case and we end with the Rosenblatt process case. In particular, for the Rosenblatt process, we separate the studies of the $(L^2)$-convergences for each


17; in the Free State Zuma got 324 votes and Motlanthe none; and in the Northern Cape, Zuma got 169 votes and Motlanthe 25.

The ANC Women's and Veterans' leagues also nominated Zuma.

Gauteng, along with the ANC Youth League, nominated Motlanthe.

Motlanthe has not yet indicated whether he would accept the nominations.the first or second experiments, with overall E. coli O157:H7 prevalence relatively low (<7%). In the third zilpaterol HCl experiment, the percentage of fecal samples that were E. coli O157:H7 positive following qualitative culture was higher (P < 0.05) in the zilpaterol HCl treatment (10.3%) than for the control (6.1%). The current research showed minimal effects of beta-agonists on fecal shedding of E. coli O157:H7 and indicated that these compounds (fed immediately prior to slaughter) are not a cause for concern from a food safety standpoint.


Shutterbugs who shunned traditional point-and-shoots in favor of Sony's QX10 and QX100 lens cameras can now take even better images and videos. Thanks to a firmware upgrade, both smartphone lens attachments are now capable of recording clips with a higher resolution (1,920 x 1,080) than before (1,440 x 1,080). It also cranks up the clip-ons' max ISO settings from 1,600 to 3,200 on the QX10 and from 3,200 to 12,800 on the QX100, which is bound to please those especially fond of nighttime photography. Other than these two feature boosts, folks with the more expensive QX100 get an extra shutter speed mode for their devices. Unfortunately, users can't upgrade over their phones and will have to download the firmware on a Windows (XP/Vista/7/8) or a Mac computer.counts the degrees of freedom of each species including its statistics, that is, $n_j>0$ ($n_j<0$) for bosons (fermions). $m_j$, which is a function of the Higgs background $(\rho_i,\theta)$, is the mass eigenvalue of each species.

At the one-loop level, $\left(m_3^2\right)_{\rm eff}$ receives corrections only from the Higgs bosons, squarks, sleptons, and charginos and neutralinos. $\lambda_{5,6,7}$, which are zero at the tree level, are generated only through the loops of these particles. Among them, we consider the contributions of charginos($\chi^{\pm}$), neutralinos($\chi^0$), stops(${{\tilde t}}$) and Higgs($\phi^{\pm}$). The effective parameters are defined as the derivatives of $V_{\rm eff}$ at the origin of the order-parameter space: $$\begin{aligned}
 \left(m_3^2\right)_{\rm eff} &=&
 -\left.{{{\partial}^2 V_{\rm eff}}\over{{\partial}v_1{\partial}v_2}}\right|_0 =
 m_3^2 + \Delta_{\chi}m_3^2+ \Delta_{\tilde t}m_3^2 +


below which the Higgs contributions are neglected. The effective parameters are plotted in Figs. \[fig:9\] and \[fig:10\].

=11.6cm

=11.6cm

Since $$B_2/T = 3.447779\times10^{-5},\qquad
 C_1/T = 7.269727\times10^{-3},$$ $F(\rho_1,\rho_2)>0$ for $\rho_2>16.05$ at $T=100$. The almost whole region where ${\left|G(\rho_1,\rho_2)\right|}<1$ satisfies this condition as well, as shown in Figs. \[fig:11\] and \[fig:12\]. The positive $C_1$ requires smaller $m_3^2$ than that for $C_1<0$ to make $2\left(m_3^2\right)_{\rm eff}+2C_1\rho_2$ nearly equal to $\lambda_6\rho_1^2+\lambda_7\rho_2^2$.

=11.6cm

=11.6cm

\(2) $\tan\beta_0=5$\
Now $T_{\rm low}=313.08$. We completely ignore the Higgs contributions in the plots of the effective parameters in Figs. \[fig:13\] and \[fig:14\].

=11.6cm

=11.6cm

By the same reasoning as in the case of $\mu A_t>0$, the temperature at which ${\left|G(\rho_1,\rho_2)\right|}<1$ is lowered. At the same time, $\lambda_5$ becomes larger at lower temperatures so that the region with ${\left|G(\rho_1,\rho_2)\right|}<1$ grows as seen from Figs. \[fig:15\] and \[fig:16\]. For this parameter set, we have&{}
  \times\left[(k^2-P^2)Q^2 + PQR^2 \right], \\
 \Delta_{\chi^0} \lambda_6 &=& \Delta_{\chi^0} \lambda_7 =
 2(g_2^2+g_1^2) \mu\,i\int_k^{(+)}
  \Delta_1^2(k)\Delta_2^2(k)\Delta_3^2(k) k^2(k^2-P^2-R^2) \nonumber\\
  & &{}
  \times\left[(2k^2-2P^2-R^2)Q + PR^2 \right],\end{aligned}$$ where $$\begin{aligned}
 \Delta_1(k) &=& {1\over{k^2-\mu_1^2}},\quad
 \Delta_2(k) = {1\over{k^2-\mu_2^2}},\quad
 \Delta_3(k) = {1\over{k^2-\mu^2}},   \\
 \mu^2_{1,2} &=&
 {{P^2+Q^2+2R^2\pm{\left|P+Q\right|}\sqrt{(P-Q)^2+4R^2}}\over2},\end{aligned}$$ with $$\begin{aligned}
 P &=& M_2\sin^2\theta_W + M_1\cos^2\theta_W, \\
 Q &=& M_2\cos^2\theta_W + M_1\sin^2\theta_W, \\
 R &=& (M_2-M_1)\sin\theta_W\cos\theta_W.\end{aligned}$$ If $M_1=M_2$, $P=Q=M_2$ and $R=0$ so that $\mu_1=\mu_2=M_2$. In this case the neutralino contributions are reduced to $$\begin{aligned}
 \Delta_{\chi^0} m_3^2 &=&
 {1\over{\cos^2\theta_W}} \Delta_{\chi^\pm} m_3^2,   \\
 \Delta_{\chi^0} \lambda_5 &=&
 {2\over{\cos^4\theta_W}} \Delta_{\chi^\pm} \lambda_5, \\
 \Delta_{\chi^0} \lambda_6 &=&
 \Delta_{\chi^0} \lambda_7 =
 {2\over{\cos^4\theta_W}} \Delta_{\chi^\pm} \lambda_6 =
 {2\over{\cos^4\theta_W}} \Delta_{\chi^\pm} \lambda_7.\end{aligned}$$ We consider this special case of $M_2=M_1$ for simplicity.

The corrections to the effective parameters from the charged Higgs bosons


defective. Defendant also has filed a motion pursuant to Fed.R.Civ.P. 42(b) to conduct separate trials on the issues of liability and damages. Intervening Plaintiffs, Envirex and Crawford & Company, ask the Court to strike certain defenses that Defendant has incorporated in its Answer to the Intervening Complaint and its Answer to Plaintiff's original Complaint. For reasons that will be explained below, the Court denies Defendant's motion for summary judgment. The Defendant's motion to bifurcate the trial is granted. Intervening Plaintiff's motion to strike is granted in part and denied in part.

BACKGROUND
On January 31, 1989, Plaintiff was electrocuted while changing a light bulb at his place of employment, Rexnord, Inc., in Madison, Indiana. Rexnord is now known as Envirex, Inc. According to Plaintiff, when he attempted to unscrew thelight bulb. Plaintiff disputes both arguments.

DISCUSSION

A. Defendant's Motion for Summary Judgment

1. Summary Judgment Standards

Under Rule 56(c) of the Federal Rules of Civil Procedure, summary judgment is proper "if the pleadings, depositions, answers to interrogatories, and admissions on file, together with the affidavits, if any, show that there is no genuine issue as to any material fact and that the moving party is entitled to a judgment as a matter of law." Fed.R.Civ. Proc. 56(c). While the burden rests squarely on the party moving for summary judgment to show "that there is an absence of evidence to support the nonmoving party's case", Celotex Corp. v. Catrett, 477 U.S. 317, 325, 106 S.Ct. 2548, 2554, 91 L.Ed.2d 265 (1986), the nonmoving party responding to a properly made and supported summary


to the contributory fault chargeable to Bruther or to others;". The Court also strikes that portion of the Twelfth Defense included in Defendant's Answer to Plaintiff's Complaint which states: "That any amount awarded to the Bruthers as compensatory remuneration for damage or injury be diminished proportionate to the contributory fault chargeable to Bruther or to others;".

CONCLUSION
Because there remain genuine issues of material fact in this case, Defendant's motion for summary judgment is DENIED, and the Defendant's motion to bifurcate the trial on the issues of liability and damages is GRANTED. Intervening Plaintiff's motion to strike is GRANTED in part and DENIED in part.
It is so ORDERED.

PARTIAL JUDGMENT
In accord with the Court's Entry in the above named action, the Defendant's motion for summary judgment is denied, and the Defendant'sDiaz was one of several people who recently told us on Facebook that toys were among their most sought-after-items this time of year.

"Paw patrol: sea patrol. My (12-year-old autistic son) asked for it," Amber Schweigert wrote. "First time he has ever really asked for a toy for Christmas. And its sold out at most of the stores around here."

To help you finish your holiday shopping list, we've put together a list of some of the best deals on popular toys we could find online. Scroll down for links. The deals were active and in stock at the time of publication.

Ian Hill is a former journalist and manager for TEGNA, the company that owns this station.

TEGNA’s e-commerce team has curated on this page some of the gifts our Facebook


Fred Haney

Fred Girard Haney (April 25, 1896 – November 9, 1977) was an American third baseman, manager, coach and executive in Major League Baseball (MLB). As a manager, he won two pennants and a world championship with the Milwaukee Braves and, as an executive, he was the first general manager of the expansion Los Angeles Angels of the American League. For years, Haney was one of the most popular baseball figures in Los Angeles. In 1974 he was presented with the King of Baseball award given by Minor League Baseball.

Born in Albuquerque, New Mexico, and raised in Los Angeles, Haney's major league playing career lasted all or part of seven seasons (1922–27, 1929). Primarily a third baseman—despite his diminutive (5 feet, 6 inches/1.67 m) size—Haney compiled a .275 battingother moments of encouragement for his side.

"We knew that this could happen before now," he told Sky Sports. "I think I saw a game with a good balance. They scored a goal at the end of the first half and then they scored the second goal in our best moment.

"It's a pity to stop this run but Tottenham is a good team, a really strong team and I think for sure they are one of the teams who can fight for the title until the end.

"They fought last season and for sure Tottenham can fight also this year.

"Two good teams with good intensity and good pressure tried to win the game. Tottenham scored in two strange moments [especially in] the second half when we missed two chances to


>> Windows >> Call Stack

As you can see the image with the help of the Call Stack Window you will get information about the method get called, what is parameter value, line no of the method in file, is it external call or internal, programming language in which method written.

Immediate Window
It always happen that in middle of debugging you want to execute some set of statement or some set of function or want to check the value of the variable. But as beginner you don't know how to do it at time of debug ?

You can open up the Immediate window by shortcut Ctrl + Alt + I or go to menu Debug >> Windows >> Immediate Window

Immediate window has intelligence support as we have in the Coding  ]);

        $photo = new Photo();
        $photo->user_id = Auth::id();
        $photo->path = $this->uploadImg($request->file('file'), 'submissions/img');
        $photo->thumbnail_path = $this->createThumbnail($request->file('file'), 600, null, 'submissions/img/thumbs');
        $photo->save();

        return new PhotoResource($photo);
    }

    /**
     * Get the uploaded photo.
     *
     * @param integer $photo
     *
     * @return PhotoResource
     */
    public function get(Photo $photo)
    {


 $image = Image::make($request->file('photo')->getRealPath());
        $folder = 'channels/avatars';

        // crop it
        $image = $image->resize(250, 250);

        // optimize it
        $image->encode('png', 60);

        // upload it
        Storage::put($folder . '/' . $filename, $image);
        $imageAddress = $this->webAddress() . $folder . '/' . $filename;

        // delete the old avatar
        Storage::delete('channels/avatars/' . str_after($channel->avatar, 'channels/avatars/'));

        // update channel's avatar
 Nonequilibrium unfolding of polyelectrolyte condensates in electric fields.
Using simulations and scaling methods, the effect of an electric field on a collapsed polyelectrolyte globule is investigated, where conduction by counterions and the polyelectrolyte itself is taken into account. At a critical field E(*), a nonequilibrium transition occurs at which the polyelectrolyte unfolds and aligns parallel to the external field. E(*) is determined using scaling results for the polarizability of a polyelectrolyte globule and exhibits a dependence on the chain length N, E(*) approximately N(-1/2), which might be useful for electrophoretic separation of charged biopolymers.


February 27, 2007 Wiltshire County, England - One earth mystery that has been described by eyewitnesses is the sudden appearance "out of nowhere" of what seems to be a child or adult person. Some have observed mysterious balls of light from which individuals emerge. One example was reported in a 1989 book, Unexplained Mysteries of the 20th Century by Janet and Colin Bord. They wrote: "The witness was climbing in the Bavarian Alps of West Germany around 1950 and she got lost. 'All of a sudden, I noticed a sort of a big ball of light and this condensed into the shape of a tall, rather Chinese-looking gentleman. ...He bowed, spoke a few words, led me by a small path to the tourists' way and disappeared back asa ball of light.'"

This site uses cookies to store information on your computer. Some are essential to make our site work; others help us improve the user experience. By using the site, you consent to the placement of these cookies.OKRead more


assistant city manager Larisa Sims said Tuesday night.

In for a penny, in for a pound

So, why not dream even bigger?

If the city could get the plans to be worth more than $10 million, it would meet the requirements under the Transportation Investment Generating Economic Recovery (TIGER) grants from the US Department of Transportation.

The case made Tuesday by Sims and city engineer Mike Yeager appears to be strong. The money would not only be used to create an economic development attraction from the Licking River to where the Waterfront restaurant floated for more than twenty years before accidentally floating away in 2011 and then announcing plans to return at Covington Landing before accidentally floating away again and sailing off for repairs in Boone County (the Waterfront's plans are stillarea on the riverbank near Madison Place, an entertainment oval for events, a trail feature that brings guests within an inch of the water, all highlighted by attractive lighting, bike racks, and benches. "All those types of amenities you would expect to see when you're biking, hiking, or coming to events," Sims said.

The Western Walk would lead visitors from Covington Landing to the former Waterfront site via an 8-foot wide trail that culminates with a recreation attraction unlike any other around. There would maybe be a zipline, climbing towers, moon bounces, and a structure to provide views into the city and across the river. "This is not provided in the region," Sims said. "It would be a service to folks that are here and people that are coming


of the overall project. "We welcome the project and we share your enthusiasm and we thank you for all of your efforts, for sure," he said. "We know this is not an easy task. You have to please a lot of people and that in and of itself is a big challenge."1. Technical Field
The present invention relates to a liquid container retaining unit for retaining a liquid container capable of storing a liquid, and a liquid ejecting apparatus including the liquid container retaining unit.
2. Related Art
An example of a known liquid ejecting apparatus is an ink jet printer in which a liquid stored in a liquid container is supplied to a liquid ejecting head from which the liquid is ejected onto printing media, such as paper sheets or the like, to form an image or the like. Such a printer typically includes a liquid container retaining unit having a container retaining element for retaining a plurality of liquid containers in an insertable and removable manner. Then, in the printer, for image formation, liquids are supplied from the liquid containers


Great Expectations by Charles Dickens, Chapter
1.
My father's family name being Pirrip, and
my Christian name Philip, my infant tongue
could make of both names nothing longer or
more explicit than Pip. So, I called myself
Pip, and came to be called Pip.
I give Pirrip as my father's family name,
on the authority of his tombstone and my sister,—Mrs.
Joe Gargery, who married the blacksmith. As
I never saw my father or my mother, and never
saw any likeness of either of them (for their
days were long before the days of photographs),
my first fancies regarding what they were
like were unreasonably derived from their
tombstones. The shape of the letters on my
father's, gave me an odd idea that he was
a square, stout, dark man, with curly black
hair. From the character and turn of the inscription,
"Also Georgiana Wife of theI'll cut your throat!"
A fearful man, all in coarse gray, with a
great iron on his leg. A man with no hat,
and with broken shoes, and with an old rag
tied round his head. A man who had been soaked
in water, and smothered in mud, and lamed
by stones, and cut by flints, and stung by
nettles, and torn by briars; who limped, and
shivered, and glared, and growled; and whose
teeth chattered in his head as he seized me
by the chin.
"Oh! Don't cut my throat, sir," I pleaded
in terror. "Pray don't do it, sir."
"Tell us your name!" said the man. "Quick!"
"Pip, sir."
"Once more," said the man, staring at me.
"Give it mouth!"
"Pip. Pip, sir."
"Show us where you live," said the man. "Pint
out the place!"
I pointed to where our village lay, on the
flat in-shore among


by both arms, and tilted me back as far
as he could hold me; so that his eyes looked
most powerfully down into mine, and mine looked
most helplessly up into his.
"Now lookee here," he said, "the question
being whether you're to be let to live. You
know what a file is?"
"Yes, sir."
"And you know what wittles is?"
"Yes, sir."
After each question he tilted me over a little
more, so as to give me a greater sense of
helplessness and danger.
"You get me a file." He tilted me again. "And
you get me wittles." He tilted me again. "You
bring 'em both to me." He tilted me again.
"Or I'll have your heart and liver out." He
tilted me again.
I was dreadfully frightened, and so giddy
that I clung to him with both hands, and said,
"If you would kindly please tolet me keep
upright, sir, perhaps I shouldn't be sick,
and perhaps I could attend more."
He gave me a most tremendous dip and roll,
so that the church jumped over its own weathercock.
Then, he held me by the arms, in an upright
position on the top of the stone, and went
on in these fearful terms:—
"You bring me, to-morrow morning early, that
file and them wittles. You bring the lot to
me, at that old Battery over yonder. You do
it, and you never dare to say a word or dare
to make a sign concerning your having seen
such a person as me, or any person sumever,
and you shall be let to live. You fail, or
you go from my words in any partickler, no
matter how small it is, and your heart and
your liver shall be tore out,


the nettles, and
among the brambles that bound the green mounds,
he looked in my young eyes as if he were eluding
the hands of the dead people, stretching up
cautiously out of their graves, to get a twist
upon his ankle and pull him in.
When he came to the low church wall, he got
over it, like a man whose legs were numbed
and stiff, and then turned round to look for
me. When I saw him turning, I set my face
towards home, and made the best use of my
legs. But presently I looked over my shoulder,
and saw him going on again towards the river,
still hugging himself in both arms, and picking
his way with his sore feet among the great
stones dropped into the marshes here and there,
for stepping-places when the rains were heavy
or the tidea manufacturing tech lead, said. He voluntarily works extra shifts to pull 70 hours a week in Tesla's outdoor makeshift Model 3 production area in Fremont. "This is nothing."

He went on: "Two years ago I was sleeping in a car. I've been here two years now, and I'm getting ready to buy a house. A lot of things have come together for me from this company, for me putting in the hours. To me, this is the best company ever."

But to really understand Tesla, you have to understand how employees feel about their larger-than-life leader.

The 'cult of Elon'

It's time for the quarterly all-hands meeting, and people are standing around nervously like groupies waiting for a glimpse of Musk, their famous CEO. As he walks to the front of


systems."

Several other current employees told us the same. While injuries may happen, safety, particularly over the past year, has been a major emphasis, with workers getting constant reminders, training, and new procedures.

A software engineer said the engineering managers who work on the production lines are "conscientious people" who care deeply about the workers and are always looking for ways to improve the process.

For instance, the Model 3 production lines, the latest to be built, include fancy ergonomics adjustments. Employees can wear sensor suits that track their movements to minimize repetitive stress injuries. Workstations can be raised up or moved about to adjust to the worker, Crystal Spates, a Model 3 production manager, said.

The company has hired six athletic trainers to help workers who complain of aches and pains,medical attention, the line does return to business. In other industrial settings, if the accident is serious enough, workers who see the incident could be sent home, Phillips asserts. "Because nobody can keep their mind on their work when they've seen something terrible happen to somebody," he said.

911 calls made to Tesla's Fremont factory versus GM's Lake Orion factory

Time to grow up?

While Tesla's happiest employees love the company like a second family, not everyone feels that way. Tesla is facing several lawsuits from employees alleging safety violations, harassment, and more. Tesla denies the validity of the lawsuits, making counter allegations against the people suing and the circumstances cited in their suits.

Mark Cuyler, an operations manager at Tesla, walks a Model S through the company's factory in Fremont, California,


[Correlation analysis between imaging features and lymph node metastasis in T1a lung adenocarcinoma].
To analyze the data of patients with clinical stage T1a lung adenocarcinoma and find the predictive factors associated with lymph node metastasis. From January to June 2012, 271 patients with small nodules of peripheral lung adenocarcinoma were enrolled in the retrospective review. There were 105 male and 112 female patients, with an average age of (61 ± 11)years (range 32-85 years). The data were collected including age, gender, smoking history, carcinoembryonic antigen(CEA), imaging findings, surgical procedure, pleural involvement, symptoms, tumor size, pathological classification, pathologic stage, maximum standardized uptake value(SUVmax) and lymph node metastasis. The predictive factors of lymph node metastasis in clinical factors were detected by univariate and multivariate analysis. By preoperative thin-section CT, 35 patientsto remember, so it isn’t the easiest method.

Cloud-Based File Hosting Services

These sites store and organize any files that you upload and are stored in the cloud so they can be accessed almost anywhere on any device. They often include tools that make sharing and collaborating a lot easier. Most sites have a small limit of free storage and then you can purchase more storage as you need it. These sites are typically just for working files and not total hard drive backups. Popular sites include Dropbox, Box, iCloud, and GoogleDrive. I like Dropbox because of how well it integrates with my laptop and other devices.

Full-Service Backup Companies

Some companies provide cloud backups of your entire computer using their software. You don’t have to worry about much, but you are


genealogists were left in the lurch trying to quickly find a way to extract their data and migrate it to a new system (before it announced the software was purchased by MacKiev, who continues to administer the program).

There is a multitude of proprietary and open source genealogy programs, most of which have files saved in different formations. Fortunately, most family tree software programs and websites support importing and exporting the GEDCOM file format. The GEDCOM file makes it easier to take the information and relationships for people in your family trees and map this same data to other genealogy programs. Consider occasionally exporting a GEDCOM of your family tree and backing it up with the rest of your files as a failsafe.

To export from Ancestry.com, select your family }

    @BuildStep(onlyIf = MicroprofileMetricsEnabled.class)
    UnremovableBeanBuildItem processAnnotatedMetrics(BuildProducer<GeneratedBeanBuildItem> generatedBeans,
            BuildProducer<AnnotationsTransformerBuildItem> annotationsTransformers,
            CombinedIndexBuildItem indexBuildItem) {
        IndexView index = indexBuildItem.getIndex();
        ClassOutput classOutput = new GeneratedBeanGizmoAdaptor(generatedBeans);

        // Gauges.
        GaugeAnnotationHandler.processAnnotatedGauges(index, classOutput);
        annotationsTransformers.produce(AnnotationHandler.transformAnnotations(index,
                MetricDotNames.CONCURRENT_GAUGE_ANNOTATION));

        // Invocation counters
        annotationsTransformers.produce(AnnotationHandler.transformAnnotations(index,


   MetricDotNames.METRIC_ANNOTATION));

        return new UnremovableBeanBuildItem(new Predicate<BeanInfo>() {
            @Override
            public boolean test(io.quarkus.arc.processor.BeanInfo beanInfo) {
                if (beanInfo.hasType(MetricDotNames.METRIC) ||
                        beanInfo.hasType(MetricDotNames.ANNOTATED_GAUGE_ADAPTER)) {
                    return true;
                }
    of its own funds on a phased implementation.

Small Diversion at Hope Canal — $68.6 million. Corps involvement never initiated because state determined the costs were too high. State is proceeding on its own using state funds and expectation of RESTORE Act funding.

Point Au Fer Island shoreline restoration — $43.4 million. Study suspended by the state because project did not pass Master Plan review.

Land bridge between Caillou Lake and Gulf of Mexico — $56.3 million. Study suspended by state because project did not pass Master Plan review

Modification of Caernarvon Diversion — $20.7 million. Study suspended by state after spending $2 million because objective did not pass Master Plan review.

Modification of Davis Pond Diversion — $64.2 million. Study suspended by state after spending $2 million because objective did not pass


$29.7 million share.

“We wanted to see how we could move more sediment through these diversions, which we now know would mean modifying the structures – making them deeper, for one thing,” he said. “But we realized the corps was only looking at modifying the flow regime.

“So they were looking at paperwork, and we were looking at construction. We would be wasting state money if we continued.”

And by 2010 it was becoming obvious there wouldn’t be much, if any, money coming from Congress for construction. With the Master Plan requiring spending about $1 billion per year for 50 years to stay ahead of subsidence and sea level rise, the future was looking bleak.

Then a disaster provided a temporary solution.

Deepwater Horizon

Although the environmental and economic costs exacted by the Deepwaterat Abu Dhabi Commercial Bank, in a research note.

“The developments also have significance ahead of the planned part-IPO of Aramco, highlighting the potential vulnerability of its key infrastructure and raising questions over the appropriate level of risk to be factored in the valuation.”

Banks including JPMorgan JPM.N, Morgan Stanley MS.N and Goldman Sachs GS.N have been appointed to coordinate the deal, which has already faced repeated delays and is crucial for Prince Mohammed's plans to diversify the Saudi economy in an era of low oil prices.

(This version of the story removes extraneous words in headline)


yet vasculitis may also be found within the granulomatous inflammation \[[@B2]\]. The latter may affect virtually any organ, with a predilection for lung and kidney involvement (necrotizing, predominantly small-vessel pauci-immune vasculitis, that is, manifesting as pulmonary capillaritis and crescentic glomerulonephritis) \[[@B3],[@B4]\]. There is some evidence from *in vitro*and *in vivo*studies that ANCAs play a crucial role in the mediation of small-vessel vasculitis \[[@B5]-[@B7]\]. In WG, ANCAs are mainly directed against Proteinase 3 \[[@B4]\] and are implicated in the activation of polymorphonuclear neutrophils by interacting with Proteinase 3 expressed on the plasma membrane of these \[[@B5]\].

Disease stages
--------------

According to a concept by Fienberg \[[@B8]\], WG starts as \'granulomatous\' disease of the upper and lower respiratory tracts and subsequently progresses to generalized (\'systemic\') disease characterized by clinical vasculitis manifestations, such asbut is the most frequent manifestation of WG \[[@B4]\], and for these two reasons is indicative of WG: patients typically present with rhinosinusitis with bloody discharge, crusting and epistaxis. Nasal crusting (\'golden crusts\') is a typical finding of endoscopic evaluation.

Granulomatous inflammation and/or mass formation may be found in the nasal cavity, sinuses and within the orbits but also frequently in the lower respiratory tract as pulmonary \'granuloma\' \[[@B3],[@B4]\] (Figure [1](#F1){ref-type="fig"}). Orbital masses, either perforating from the sinuses or developing within the orbit in isolation, are a serious complication of upper respiratory tract disease in 15 to 20% of patients \[[@B4]\]. The nature of granulomatous inflammation is destructive, as a significant proportion of patients develop signs of cartilage and bone erosion during the course of disease (that is, saddle


It is recommended to treat AAV patients at or in cooperation with specialist centers \[[@B11]\]. All AAV patients require a work-up that includes examination of lung (X-ray, lung function testing and HRCT, and fiberoptic bronchoscopy with bronchoalveolar lavage if necessary) and kidneys (ultrasound, assessment of creatinine clearance and microscopic hematuria, red cell casts and proteinuria) and testing for ANCAs. In addition, WG patients should be seen by an otorhinolaryngologist and CSS patients require assessment of pulmonary function and allergy testing. At first presentation, confirmation of diagnosis should be sought by biopsy - for example, nasal mucosa and lung or kidney biopsy. Depending on disease symptoms and suspected organ manifestations, additional evaluations by a neurologist, ophthalmologist and dermatologist and/or additional technical examinations, such as MRI of sinuses and orbits,\[[@B60]\]. Interestingly, patients died rather from infections than from acute vasculitis \[[@B60]\].

Treatment and outcome of Churg-Strauss syndrome
-----------------------------------------------

In general, principles of treatment for CSS are the same as for the other AAVs. A stage- and disease activity-adapted approach is recommended. To guide therapy, the FFS as an additional instrument should be used \[[@B34]\]. Glucocorticoids (GCs) represent the mainstay of CSS treatment. In most cases relatively high doses have to be used for longer periods of time. As evidence accumulates that GCs are also the most significant risk factor for severe infections (see below) and long-term use is associated with a high burden of co-morbidity, therapy should aim to keep GC dose as low as possible. Concomitant treatment with high-dose inhaled corticosteroids may help to control asthma in CSS and


indicated. Rituximab may also be of benefit in the treatment of CV \[[@B11]\].

Small vessel vasculitis with lung involvement and consecutive alveolar hemorrhage may also develop rarely in collagen vascular diseases (such as systemic lupus erythematosus and systemic sclerosis).

Panrarteritis nodosa (PAN) is a systemic necrotizing vasculitis that predominantly affects medium-size arteries and may lead to stenosis or formation of micro-aneurysms, which can rupture and cause major bleeding. PAN is primary in the majority of patients but may also occur in association with viral infections, especially with hepatitis B virus. Apart from constitutional symptoms, peripheral neuropathy, skin involvement (livedo, purpura, digital ischemia), gastrointestinal involvement with bleeding and perforation, renal artery stenosis and hypertension are common \[[@B72]\]. Pulmonary involvement (lung infiltrates, pleural effusions) is rare (in around 4% of patients \[[@B72]\]).  	$othercurrencyname->addValidator("regex",true,array(
	    			'pattern'=>'/^[a-zA-Z][a-zA-Z0-9\s]*$/',

	    			'messages'=>array(
	    					'regexNotMatch'=>'Please enter valid currency name.'
	    			)
	    	));

	       $othercurrencyname->addValidator(new Zend_Validate_Db_NoRecordExists(
	    			array('table'=>'main_currency',
	    					'field'=>'currencyname'

	    			))
	    	);

	    $othercurrencyname->getValidator('Db_NoRecordExists')->setMessage('Currency name already exists.');

	    $othercurrencycode = new Zend_Form_Element_Text('othercurrencycode');
	    $othercurrencycode->setAttrib('maxLength', 50);

	    $othercurrencycode->addFilter(new Zend_Filter_StringTrim());
	    $othercurrencycode->setRequired(true);
	    $othercurrencycode->addValidator('NotEmpty', false, array('messages' => 'Please enter currency code.'));

	    $othercurrencycode->addValidator("regex",true,array(


'Regex',
			             'breakChainOnFailure' => true,
			             'options'     => array(
			             //'pattern' => '/^[A-Za-z]+$/',
			         	 'pattern'=> '/^[A-Za-z][a-zA-Z@\-]*$/',
			                 'messages' => array(
			                     Zend_Validate_Regex::NOT_MATCH =>'Please enter valid employee code.'
			                 )
			    Repentance is central to the Christian experience and is a recurrent theme in the gospels. For example, in Matthew 3:2, where the call to repentance is issued by John the Baptist, the underlying Greek word is a loaded term, metanoia, which implies a change in thinking. In Latin this became poenitentiam agite—do penance, reflecting the Christian conviction that true repentance is expressed in words as well as deeds. This verse had become so closely associated with the sacrament of penance that Erasmus’ attempt to change the Latin translation caused such an uproar he had to change it back. While Erasmus perhaps should be credited with seeking to recover the original sense of the Greek, which emphasized sorrow and a shift in thinking, this meaning was preserved in the


25 or so, James Karst said. His residence there coincided with his most active and fertile time as a musician, and the family's move, "to a much shabbier house" nearby, said Karst, was timed to his decline.

The house was included on the Louisiana Landmarks Society's annual list of the city's nine most endangered properties in 2011, when it was also cited for blight (as it was in 2014, too). At that time, according to a report in the New Orleans Advocate, the Preservation Resource Center, an organization that advocates for the preservation of historical architecture in the city, offered to help renovate the landmark and find a new buyer, as it had done with the historic homes of other early jazz artists. But the church declined to sell,tell us?" he said. "'We shall know by their acts.'") This is less cynicism toward the new Foundation and the church in particular and more a learned response to New Orleans' track record with the physical markers of its extensive musical legacy. Louis Armstrong's birthplace was torn down in the sixties as part of the construction of a new police headquarters and court complex. The site of J&M Studios, where Cosimo Matassa waxed hundreds of groundbreaking early rock and R&B recordings, is now a laundromat. The Dew Drop Inn, a major locus of black music and cultural life in the city from World War II until the '70s, stood shuttered and crumbling for decades, as did the Eagle Saloon and Odd Fellows Hall on South Rampart Street. The


     * maximum time in milliseconds to wait for acquiring the lock for the key.
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        public long timeout;
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    public static ClientMessage encodeRequest(java.lang.String name, com.hazelcast.internal.serialization.Data key, com.hazelcast.internal.serialization.Data value, long threadId, long timeout) {
        ClientMessage clientMessage = ClientMessage.createForEncode();
        clientMessage.setRetryable(false);
        clientMessage.setOperationName("Map.TryPut");
        ClientMessage.Frame initialFrame = new ClientMessage.Frame(new byte[REQUEST_INITIAL_FRAME_SIZE], UNFRAGMENTED_MESSAGE);
        encodeInt(initialFrame.content, TYPE_FIELD_OFFSET, REQUEST_MESSAGE_TYPE);
        encodeInt(initialFrame.content, PARTITION_ID_FIELD_OFFSET, -1);
        encodeLong(initialFrame.content,SPREADSHEETS OR ASSET MANAGEMENT SOFTWARE?

Published November 2015

I love spreadsheets as much as all the business guys. Pivot Tables, Formula’s, Chart’s, Bar charts… all of them make you feel that you are under full control. Needless to say, spreadsheets are a great starting point to manage your assets.

As soon as number of users increase, ugly faces of duplication, data entry errors, version control, risk of spreadsheets being part of personal emails or USB sticks cause more dent to your asset management strategy than you think.

We have all witnessed data entry issues, duplication, version control issues etc. None of them are intentional. For example; the difference between 2 and 20 from a data entry viewpoint is not much. A user has just missed typing a zero or thought he typed


the software and are relying on social engineering and a preference that is often set on Android devices when people want to install software that is not from the official Android Market.

Drive-by downloads such as this are common for Windows PCs, but the sites serving up NotCompatible are being selective; when a user visits one of the sites that is serving up the malware, androidonlinefix.info, the browser's User-agent string is checked and the malware only sent if it contains the word Android.

The malware itself appears to be a simple TCP relay/proxy which could be used to access private networks; it appears to call out to command and control servers at, among others, notcompatibleapp.eu and could allow the operators of the server to route connections from outside a firewallnative speakers (parents/guardians) guiding you to fluency. So, how do we learn a language?

Understanding Language Acquisition Through Theories

To begin to understand that, you need to look into the main concepts of language acquisition theory. Keep in mind that these are just theories. They have positives and negatives, and some of them even have conflicting views and parts that have been argued against using scientific evidence. Either way, they give insight into how we learn a language.

And as someone on the journey to learn a new language, having an understanding of the language learning process is CRUCIAL. Armed with it, you’ll know what works, what doesn’t, and how to chase after your dream of learning a new language to finally achieve fluency FASTER. These are the 7 leading language


though is the importance of feedback in some form. Language-learners need feedback for success. They also need a feeling of accomplishment to move forward in their language learning studies.

5. Chomsky and Universal Grammar

Famously, Noam Chomsky argues against many of Skinner’s Theory of Behaviorism with his own Theory of Universal Grammar (the 1950s). This was pretty much the antithesis of Skinner’s theory. Chomsky believed in at least some innate ability in humans for language and a limited number of ways to organize language in our minds. His proof was the fact that there are some universal elements in all languages.

Essentially, we’re all born with the ability to learn languages as a result of a Language Acquisition Device (LAD). This is a theoretical component of the mind that allows anyonethe true fraction of KOI host stars with companions is larger; @horch14 derived that fraction to be 40%-50%, consistent with the findings of @raghavan10.

Since the beginning of the [*Kepler*]{} mission in March 2009 and beyond its end in May 2013, high-resolution imaging of KOI host stars has been carried out as part of the [*Kepler*]{} Follow-Up Observation Program (KFOP). In addition, several observing teams that were not part of KFOP carried out imaging surveys of KOI host stars. Besides imaging, spectroscopic observations were obtained by KFOP and other teams both to constrain stellar parameters and to measure the planets’ radial velocity signals. All these observations focused on targets of the original [*Kepler*]{} mission and not its successor, [*K2*]{}. Most of the results have been posted on the [*Kepler*]{}


Community Follow-Up Observation Program (CFOP) website[^1], which is meant to facilitate information exchange among observers.

In this work we present in detail the follow-up observations by our KFOP team using adaptive optics in the near-infrared with instrumentation on the Keck II, Palomar 5-m, and Lick 3-m telescopes, as well as results from our optical imaging using speckle interferometry at the Gemini-North telescope, the Wisconsin-Indiana-Yale-NOAO telescope, and the Discovery Channel Telescope. We and additional, independent teams have already published other high-resolution imaging observations of KOI host stars using some of these telescopes, as well as the Calar Alto 2.2-m telescope, Multiple Mirror Telescope, Palomar 1.5-m telescope, and Hubble Space Telescope [@howell11; @adams12; @lillo-box12; @adams13; @law14; @dressing14; @lillo-box14; @wang14; @gilliland15; @everett15; @cartier15; @wang15a; @wang15b; @kraus16; @baranec16; @ziegler16]. In particular, the Robo-AO681 stars were targeted. The more recent observing runs at the 4-m DCT telescope covered 75 stars. Overall, at all three telescopes the observations were directed at 828 unique KOI host stars.

Targets were observed simultaneously in two bands, centered at 562 nm and 692 nm (both with a band width of 40 nm), or at 692 nm and 880 nm (the latter with a band width of 50 nm). Some targets have data in all three bands. The field of view of the speckle images is smaller than that of the AO images, about 3 on each side, but the PSF widths are narrower (0.02-0.05), resulting in better spatial resolution. Some of the results on DSSI observations of KOIs can be found in @howell11, @horch12 [@horch14], @everett15, and @teske15.

A


PSF in their 24 $\times$ 24 images was typically 0.21, which is somewhat larger than the value from AO images ($\sim$ 0.15).

HST imaging using the WFC3 was carried out in the $F555W$ and $F775W$ bands [@gilliland15; @cartier15]. The images spanned a relatively large field of view of 40$\times$ 40, and the typical FWHM of the stellar PSF was 0.08.

One additional facility, the 8-m Large Binocular Telescope, was used with LMIRCam to observe 24 KOI host stars in the $K_s$ band, but results have not yet been published and are not available on CFOP. Except for one of these 24 stars (which has only one false positive transit signal), all have been observed with one or more other facilities, too.

![image](KOI2174_2MASS_J.pdf) ![image](KOI2174_UKIRT_J.pdf)

![image](KOI2174_Keck_J.pdf) ![image](KOI2174_Keck_K.pdf)

Other Imaging {#other_ima}
-------------

### UKIRT Survey

The [*Kepler*]{} field was observed atcompanions we detected; there could be more companions that were too faint or too close to the primary stars to be found in our data. Overall, at all three telescopes 770 unique KOI host stars were observed, and 242 of these stars have companions detected within 4; thus, in our AO sample the observed fraction of systems consisting of at least two stars within 4 is 31% ($\pm$2%, assuming Poisson statistics).

![Magnitude difference versus radial separation for all companions detected around [*Kepler*]{} stars with the Keck 10-m telescope in the $J$-band ([*top*]{}) and $K$-band ([*bottom*]{}). The dashed lines are the median image sensitivities from Figure \[sensitivites\_Keck\]. \[KOIs\_Keck\]](Keck_AO_multiples.pdf)

![Magnitude difference versus radial separation for all companions detected around [*Kepler*]{} stars with the Palomar 5-m telescope in the $J$-band ([*top*]{}) and $K$-band ([*bottom*]{}).


be understood in terms of the lower image sensitivity of the lucky images within $\sim$ 1 from the primary stars.

Compilation of all KOI Host Star Companions
-------------------------------------------

We combined the results on detected KOI companions from this work and the literature (see Table \[obs\_list\] for references) to create a list with the separations and position angles of the companions and any $\Delta m$ values that were measured (including their derived uncertainties, but with a floor of 0.01 mag). We limit this list to companions within 4 of each KOI host star. It is important to note that the companions are not necessarily bound; they could be background stars or galaxies that are just by chance aligned with a KOI host star, and more analysis is needed to determine whether they and theirto derive planet radii: $$\delta_{\rm obs} = \frac{F_{\rm tot}-F_{\rm transit}}{F_{\rm tot}} =
\left( \frac{R_p}{R_{\ast}} \right)^2,$$ where $F_{\rm tot}$ is the total out-of-transit flux, $F_{\rm transit}$ is the in-transit flux, and $R_p$ and $R_{\ast}$ are the planet and stellar radius, respectively. However, if there is more than one star in a system, the total flux is the sum of the stellar fluxes, but the in-transit flux depends on which star the planet transits. Thus, the observed transit depth becomes $$\delta_{\rm obs} = \left( \frac{F_{\ast}}{F_{\rm tot}} \right)
\left( \frac{R_p}{R_{\ast}} \right)^2,$$ where the star symbol denotes the star with the transiting planet. Thus, the transit depth is shallower, and the derived planet radius is smaller when the additional stars in the system are not taken into account. Given that the radii of


Correction Factors for [*Kepler*]{} Planets

Using the relations from Equations 8-11, we converted the measured $\Delta m$ values to $\Delta Kp$ values for observations in the $F555W$, $F775W$, $i$, $LP600$, 692 nm, $J$, and $K$ bands; of the 1903 KOI host stars that have nearby stars, just 12 do not have observations in any of these seven bands (and therefore do not have $\Delta Kp$ values derived for them). With $\Delta Kp$ for the companion stars, Equations \[Rcorr\] and \[Rcorr2\] can be used to derive correction factors for the planet radii.

However, Equation \[Rcorr2\] also requires the ratio of the stellar radii of the secondary and primary star. To derive an estimate of this ratio, we used the table with colors and effective temperatures for dwarf stars from @pecaut13 andassumed that primary and secondary stars are bound. We also assumed that $Kp$ magnitudes correspond to $R$ magnitudes, and we adopted effective temperatures ($T_{eff}$) for the primary stars from the stellar parameters of @huber14. Using the tabulated $T_{eff}$ values, we derived $V-R$ ($=V-Kp$) colors and absolute $V$ magnitudes ($M_{V}$) for the primary stars. Assuming primary and secondary stars are bound and therefore at the same distance from the Sun implies $M_{V, \rm sec} = m_{V, \rm sec}-m_{V, \rm prim}+ M_{V, \rm prim}$ or $M_{V, \rm sec} = Kp_{\rm sec}+(V-R)_{\rm sec}-Kp_{\rm prim}-
(V-R)_{\rm prim}+M_{V, \rm prim}$. We found the $(V-R)_{\rm sec}$ color from the @pecaut13 table that yielded a self-consistent $M_{V, \rm sec}$ value. With $M_{V, \rm sec}$ determined, the effective temperature and luminosity of the secondary star are also


brightest companion stars, respectively, we derive a mean value of 1.47 and and a median value of 1.38. These weights exemplify the assumption that planets are more likely to orbit primary rather than secondary stars, since the former typically have more massive protoplanetary disks [e.g., @akeson14] which may lead to more efficient planet formation. Assuming that planets are equally likely to orbit the primary and secondary star, the mean and median correction factors increase somewhat to 2.08 and 1.85, respectively. The histogram of our weighted average correction factors is shown in Figure \[KOI\_Prad\_correction3\]; three quarters of values are below 1.58. Therefore, in a more realistic scenario where most planets orbit the primary stars, but some orbit secondary stars, the average planet radius correction factors are typically $\lesssim$ 2.while the number of planets with radii larger than 4 [R$_{\Earth}$]{} range will be underestimated. Moreover, the search sensitivity to small planets will be lower if target stars are actually part of multiple systems, since transits of small planets will be diluted by the light from the other stars in the system and thus more difficult to detect. On the other hand, after applying radius correction factors, the decrease in the number of planets with radii up to 25% of the Earth’s radius ranges between 4 and 29% (and those with radii up to two times the Earth’s radius between 2 and 23%; see Table \[Prad\_corrections\]), depending on whether planets are assumed to orbit the primary or brightest secondary star. Thus, the occurrence rate of Earth-sized and smaller (all


R. 2015, , 813, 130 Wizinowich, P. L., Le Mignant, D., Bouchez, A., et al. 2004, Proc. SPIE, 5490, 1 Ziegler, C., Law, N. M., Morton, T., et al. 2016, , submitted

[^1]: https://exofop.ipac.caltech.edu/cfop.php

[^2]: All KOI tables can be accessed at the NASA Exoplanet Archive at http://exoplanetarchive.ipac.caltech.edu.

[^3]: Some planets were not confirmed with ancillary observations, but rather validated using statistical methods [see, e.g., @rowe14; @morton16]; in this work we we refer to both validated and confirmed planets as confirmed planets.

[^4]: Note that there are a few dozen additional confirmed planets in the [*Kepler*]{} data set that were not identified as KOIs by the [*Kepler*]{} pipeline and are therefore not included in the numbers quoted here (but they were assigned [*Kepler*]{} planet numbers). They can be found in the holdings<?php

namespace PhpOffice\PhpSpreadsheetTests\Calculation\Functions\Statistical;

use PhpOffice\PhpSpreadsheet\Calculation\Functions;
use PhpOffice\PhpSpreadsheet\Calculation\Statistical;
use PHPUnit\Framework\TestCase;

class RsqTest extends TestCase
{
    protected function setUp(): void
    {
        Functions::setCompatibilityMode(Functions::COMPATIBILITY_EXCEL);
    }

    /**
     * @dataProvider providerRSQ
     *
     * @param mixed $expectedResult
     */
    public function testRSQ($expectedResult, array $xargs, array $yargs): void
    {
        $result = Statistical::RSQ($xargs, $yargs);
        self::assertEqualsWithDelta($expectedResult, $result, 1E-12);
    }

    public function providerRSQ()
    {
        return require 'tests/data/Calculation/Statistical/RSQ.php';
    }
}


Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a naturally derived compound found in blueberries. The amount of daily pterostilbene consumption varies according to dietary fruit intake, and it has been estimated that pterostilbene content in blueberry varies from 99 ng to 520 ng/gram depending on the variety of berry ingested. Substantial evidence suggests that pterostilbene may have numerous preventive and therapeutic properties in a vast range of human diseases that include neurological, cardiovascular, metabolic and hematologic disorders (D. McCormack and D. McFadden, 2013, A Review of Pterostilbene Antioxidant and Disease Modification, Oxidative Medicine and Cell Longevity, http://dx.doi.org/10.1155/2013/575482. Further benefits of pterostilbene have been reported in preclinical trials, in which pterostilbene was shown to be a potent anticancer agent in several malignancies (D. McCormack and D. McFadden, “Pterostilbene and cancer: current review,” Journalof Surgical Research, vol. 173, no. 2, pp. 53-61, 2012). Pterostilbene is structurally similar to resveratrol, a compound found in red wine that has comparable antioxidant, anti-inflammatory, and anticarcinogenic properties; however, pterostilbene exhibits increased absorption due to the presence of two methoxy groups which cause it to exhibit increased lipophilicity and oral bioavailability. In animal studies, pterostilbene was shown to have 80% bioavailability compared to 20% for resveratrol making it potentially advantageous as a therapeutic agent. The multiple benefits of pterostilbene in the treatment and prevention of human disease have been attributed to its antioxidant, anti-inflammatory, and anticarcinogenic properties leading to improved function of normal cells and inhibition of malignant cell. The evidence reviewed by McCormack and McFadden shows that pterostilbene reduces oxidative stress (OS) and production of


with Armaan m she became his wife... N the
reluctance of Armaan to accept her to the point where Nikki's truth came
out n he started accepting her... To their first kiss... The first
night... The baby... The touches ... The embraces... The betrayal
by her sister... Her believe tht she was wrong when her heart was
telling her otherwise Armaans violent reaction on learning the truth
... The months during anjis engawnt n marriage when she had noone to
share her pain with when Armaan wasn't talking to her n te accident
cause d by Nikki losing her n armaas baby... The feeling of never
becoming. A mother ...

Se felt... It had started with her
Nikki n Armaan ... N it ended with the three o them too... The bus
stopped at an orphanage she looked out of(mon_title, mon_by, mon_img) VALUES('$mon_i_title', '$mon_i_by', '$mon_i_img')";
        echo "
Your post have been created.
";

}else{

    $sql_i = "INSERT INTO monthspicture (mon_title, mon_by) VALUES('$mon_i_title', '$mon_i_by')";
        echo "
Your post have been created. (Without image)
";
}

if (!$mysqli->query($sql_i)) {
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Tried adding: print_r($_POST); print_r($_FILES);
Array ( [mon_by] => AthaxDesigns [mon_title] => The Sunrise [mon_submit] => Opret [mon_id] => ) Array ( [mon_img] => Array ( [name] => Athax---The-sunrise.jpg [type] => image/jpeg [tmp_name] => D:\wamp\tmp\phpF488.tmp [error] => 0 [size] => 673646 ) )

A:

The problem has been found I was a dummy, and did a typo in one of my $_POST['names']; Thanks to everybody who tried


spun in new directions by the challenges of a holiday in Tunisia, it blends shimmering visuals with a nuanced probing of yawning cultural divides. Even better, it never reads like a travelogue tweaked into fiction." Neil McRae of Rover Arts, said that, "There is little in any of these stories that should be ignored or discarded; details come to us as they do in life, not strictly necessary to our understanding, but in some way enriching to it. We enter these small worlds and the lives of these others as we do our own: everything noticed, even peripherally, has its effect. A tree may be passed unremarked, but still it casts a shadow." Sue Karp, of Vue Weekly, said, "Zorn's style exemplifies the philosophy of writing that showshour. I know I went on more paths than listed on the map. This was only my second time doing any trail riding, so I wasn't sure how these paths compared to others.

I don't think so! I GPS'd that and made that map, there is only one trail in that area on on the map ( left off at land owners request ) and if you got on that trail you would have found your self in the middle of Breezy Hill farm. ( Not Beaver Brook , which has been renamed Round top farm )

Is Breezy Hill Farm the farm with the horse ring in the back? I somehow ended up there 3 times by taking 3 different paths. I felt like I was in a maze,


lol. I'll be going back down to explore and try to make sense of what I did. Nice job on the map, it must have taken a while to create

I live in between Vietnam and Callahan, closer to Framingham. It's easier for me to just jump on bike and do a loop thru Callahan and back than it is driving over to Vietnam. Vietnam has some cool stuff though, and Callahan really doesn't.

Ditto. I just moved to Framingham off Edgell Road, and though Callahan is convenient, I'd much rather make the ride at Vietnam for some better biking. I really need to learn how to get around in there!

They never hassle you for parking behind the Wendy's? They used to do once in a while. I usually parkgenotype, and 13 have CC genotype. Levels of *mir-149-5p* and *mir-149-3p* were examined in all 55 normal thyroid tissue samples. As illustrated in [Figure 1](#ijms-15-20968-f001){ref-type="fig"}, PTC subjects carrying CC genotype have lower *mir-149-5p* expression than those with TC and TT genotype; however, only the difference between CC and TC groups is statistically significant (*p* = 0.002) and an approximate two-fold change was reached. The expression level of *mir-149-3p* in thyroid tissues was too low to be detected (data not shown).

![Association between rs2292832 genotype and expression level of *mir-149-5p*.](ijms-15-20968-g001){#ijms-15-20968-f001}

[Figure 1](#ijms-15-20968-f001){ref-type="fig"} shows scatter spot charts to show the levels of *mir-149* expression in normal thyroid tissues obtained from PTC patients with various genotypes. The comparison was performed by using the Mann--Whitney *U*-test. *P*~CC\ *vs.*\ CT~ = 0.002; *P*~CC\ *vs.*\ TT~


normal macrophage mediated repair of lung tissue is deranged by continouous heavy smoking. This work represents a major conceptual shift in the understanding of this disease as well as other cancers in which there exists an in flammatory component and suggests novel strategies for disease control with clinical implications.<%
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    file: isNew() || (Datasource.file && Datasource.type != 'sqlite'),
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        Datasource.type === 'postgis'
};
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    ];
    var options = [];
    return _(obj).chain()
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        Does the layer data appear stale? Flush cache

      * Layer
      <select name='layer'>
      </select>
      This datasource has multiple layers, please choose one

    <% } %>

    <% if (type === 'sqlite') { %>

      * Datasource
      <input type='text' class='browsable' name='Datasource.file' value='<%=Datasource.file%>' size='68'/>
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-m + i + 6 = 0, 4*m - m = i + q. What is the units digit of m?
8
Let r = -77 + 105. What is the tens digit of r?
2
Let c(z) = z**3 + 5*z**2 + 5*z + 2. Suppose -2*w + 6 = -0. Suppose -w*o + 5*o + 6 = 0. What is the units digit of c(o)?
5
Suppose -l + 4*w + 73 = 0, w + 15 - 134 = -2*l. What is the tens digit of l?
6
Let b(d) = d**2 - 7*d + 4. Let s be b(7). Suppose -2*q - 4 = -s*q. Suppose 40 = 4*k + 4*u, -3*k - q*u + 7*u + 14 = 0. What is the units digit of k?
8
Let l(c) be the first derivativefrom a graph $G$ to a graph $H$ is a mapping $f:V_G\to V_H$ such that for every edge $(x,y)$ of $G$, $(f(x), f(y))$ is an edge of $H$. Note that homomorphisms require loops in $H$ whenever $(x,y)\in E_G$ and $f(x)=f(y)$. In contrast, $f$ is a *weak homomorphism* if $(x,y)\in E_G$ implies that either $f(x)=f(y)$ or $(f(x),f(y))\in E_H$. Every homomorphism from $G$ to $H$ induces also a weak homomorphism, but not conversely [@Imrich:00a].

Since every homomorphism preserves adjacency, it naturally defines a mapping $f^{1}:E_G\to E_H$ by setting $f^{1}((x,y))=(f(x),f(y))$ for all $(x,y)\in E_G$. If $f$ is surjective, we call $f$ a *vertex surjective homomorphism*, and if $f^1$ is surjective, we call $f$ an *edge surjective homomorphism*. $f$ is *surjective homomorphism* if it is both vertex- and edge-surjective [@Hell:04].

A map $f:V_G\to V_H$


Instead, they are absorbed by the body
and must be carried out in the liver detoxification. For small deviations from the optimal pH values ??could seriously affect the enzyme activity and protein-dependent
transport and support functions, the resulting acids to be transported to the cell of the excretory In order for this process to unfold, while at the same time
maintaining the intracellular, extracellular and blood pH values??, the organism is provided with various buffer systems. These systems can be found in the organic, and
the intracellular level, and work closely together. In addition to the buffering that takes place organs such as the lungs, the kidneys and bones, buffer substances, it
is particularly important role. The main ingredients are of bicarbonate buffer and hemoglobin, which are extracellular and intracellular buffers of redalso vying to
host the bank, but in the end the Indians had to settle for appointment of the first President of the lender. The first President of the Executive Board of the Russian
and the first Chairman of the Board of Directors is Brasilian.Ensimm?inen regional center bank set up in South Africa, when the headquarters was established in China.
During transport the blood from the cell and down to the excretory organs, acids through the connective tissue. This is an alkaline substance, which, according to the
insights of histological PISCHINGER, surrounded by organs and tissues, and - in his role as the operation unit - similar to the cellular cheap new balance shoes nutrition and waste management.
Histochemically in view of the connective tissue composed of proteoglycans and glycoproteins, which is as


INTRODUCTION {#S1}
============

Copy number variants (CNVs), currently defined as genomic sequences greater than one kilobase that are polymorphic in copy number, have been identified in diverse species including human, chimp, rat, mouse, and drosophila[@R1]--[@R10]. In the short interval since the discovery of wide-spread copy number variation in apparently healthy individuals, there has been rapid expansion of both CNV detection techniques and their application across a range of biological samples and species. From these studies, it is apparent that copy number variation exceeds single nucleotide polymorphisms (SNPs) as a source of genetic variation, and that many CNVs contain or overlap genes and, thereby, may have functional effects. However, the role of copy number variation in mediating both 'normal' phenotypic variation and disease susceptibility is only beginning to emerge[@R11]--[@R14].

Fundamental questions abouthematopoietic compartment, few adipose and hypothalamus eQTLs overlapped their associated traits (6.0% and 6.4%, respectively), but this was more than expected by chance (P\<1e-5 and P\<0.01 in adipose and hypothalamus, respectively). CNVRs across all length and complexity ranges were observed as eQTLs; no categorization was enriched or depleted.

Next, we asked whether any eQTLs were shared across tissues. Because we utilized expression data from different platforms, we defined expression trait overlap at the level of gene annotation rather than probe sequence. We found twenty-three eQTLs present in more than one tissue, five of which were gene-dosage effects ([Figure 5](#F5){ref-type="fig"} and [Table 2](#T2){ref-type="table"}). A correlation between *Alad* gene dosage, mRNA abundance, and enzymatic activity was previously demonstrated[@R35],[@R36] and *Alad* expression variation was associated with a *cis*-eQTL reported in an F2


of our CNVR map is that, as is true for all comparative genomic hybridization experiments, we were limited to finding variants in comparison to a reference sequence; sequences that do not exist in the C57BL/6J genome but vary in copy number among other strains were not detected. Therefore, the total extent of copy number variation relative to the union of all inbred mouse genomes must await comprehensive sequencing of other strains. However, a reasonable estimate of the amount of mouse genomic sequence lost in the C57BL/6J strain is the amount of genomic material lost per strain relative to C57BL/6J, which ranged from 16.8 to 33.8 Mb (mean = 25.5 Mb).

Using a relatively small number of inbred mouse strains, we found that all classes of CNVs were associated with1 representing perfect clustering[@R17]. We modified this function to weight groupings by their agreement with wuHMM calls. We executed PAM, varying the number of clusters from 2--7, and calculated the weighted average silhouette. The number of clusters with the maximum, modified average silhouette was selected for the number of genotypes per CNVR. Sometimes a clustering would result in a group of strains in which no wuHMM call had been made, representing a new gain, loss or abnormal genotype. These genotypes were disallowed and these strains were assigned into the same genotype label as the reference strains. CNVRs with both average silhouettes \< 0.3 and average scores \< 2.0 were discarded, as they were likely to represent spurious clusters.

CNVR validation {#S13}
---------------

61 simple CNVRs were randomly selected for validation from


study that mainly targeted segmental duplicated regions of the genome resulted in the lowest agreement (63.9%)[@R20]. Many of these regions have sparse probe coverage on the platform that we utilized and therefore are problematic regions in which to detect CNVs. The second lowest overlap (64.3%) was with a study that specifically targeted the identification of *de novo* events in C57BL/6-derived strains[@R22]. It is possible that the 36.7% of CNV content exclusive to that study was not detected here because those sequences did not exist in, or comprised an undetectable fraction of the samples used in our study. We also assessed the overlap between CNVRs in our study and others, defined across all strains, to determine the overall consensus of reported copy number variation in the inbred mouse genome.into Beadstudio software (Illumina). On-slide spot replicates were averaged by Beadstudio and individual spot data was reported. Probes were defined as 'present' in a sample when the signal was significantly higher than in a set of negative control probes, (P \< 0.05 after correcting for multiple tests). A probe was defined as present in a strain if it was called 'present' in all replicate samples of that strain. The correlation of within-strain expression profiles exceeded between-strain correlations in all but two strains (average within strain correlation = 0.9782, average between-strain correlation = 0.9528), demonstrating that the expression profiles reflect biological variation and not technical artifacts (i.e., due to differences in cell staining, sorting, RNA labeling, or hybridization).

eQTL Mapping {#S18}
------------

Expression quantitative trait mapping was implemented as previously described[@R28],[@R31],[@R32] with


                   0.47      114,162     0.55   114,162

R^2^ is the correlation coefficient for the CNVR-to-eQTL association.

Proximity is the number of bases between the nearest boundaries of the expression probe and CNVR.

Gene dosage eQTLs have a proximity = 0 (Alad, Glo1, Gbp1, Hdhd3, and Sytl3).
the Jordan Rift. This is something that is a Japanese initiative that works together with Israel, Jordan and the Palestinian Authority for the economic advancement of everyone and I think it shows that regional cooperation can work, that it can make a tangible difference.”

Netanyahu welcomed the Japanese Foreign Minister to Jerusalem, saying that “Japan and Israel are two countries separated by the vast continent of Asia.You are on the Eastern tip of Asia; we are at the Western edge of Asia. But though there is a great geographical expanse between us we share a special relationship. In fact Japan is one of Israel's oldest friends in Asia. Last year we celebrated the 60th anniversary of our diplomatic relations. We are two peoples with a proud cultural heritage and


and 9.30±1.28, respectively vs 7.82±2.14, meter/sec, P<0.001 and <0.01 respectively). There was a positive correlation between TSH and PWV in women with overt hypothyroidism and in those with subclinical hypothyroidism (P<0.05 for both). Multivariate regression analysis showed that age and diastolic blood pressure were independent determinants of PWV in women with overt and subclinical hypothyroidism (P<0.01 for all). TSH was also an independent determinant of PWV in both groups (P<0.05 for both). Conclusion: PWV is significantly higher in Egyptian women with overt and subclinical hypothyroidism as compared with normal control subjects. This denotes early increase in arterial wall stiffness in patients with hypothyroidism, even in the subclinical phase. The positive correlation between PWV and TSH in both groups of patients suggests that the risk of atherosclerosis is proportionateshall pray", and once more in the Gospel of Luke where it is written: “Jesus' anguish at Gethsemane was so deep that his sweat was as great drops of blood falling down to the ground”.

Taking after Jesus' deeds, thousands of believers flock to the Garden of Gethsemane annually

The Garden of Gethsemane - The Garden of Olives

Believed to have been an olive garden in Biblical times too, the present day Garden of Gethsemane gets its name from the Hebrew Gat Shemen, meaning an olive press. As its namesake indicates, the garden is lush with ancient olive trees creating a shaded Mediterranean-style forest that is perfect for those in search of a little seclusion and isolation.
It is commonly held by archeologists and botanists who have studied the garden's olive trees


Q:

Exponentiation operator in Swift

I don't see an exponentiation operator defined in the base arithmetic operators in the Swift language reference.
Is there really no predefined integer or float exponentiation operator in the language?

A:

There isn't an operator but you can use the pow function like this:
return pow(num, power)

If you want to, you could also make an operator call the pow function like this:
infix operator ** { associativity left precedence 170 }

func ** (num: Double, power: Double) -> Double{
    return pow(num, power)
}

2.0**2.0 //4.0

A:

If you happen to be raising 2 to some power, you can use the bitwise left shift operator:
let x = 2 << 0    // 2
let y = 2 << 1    // 4
let z = 2 << 7 Barack Obama applauds Rahm Emanuel, who is holding back tears, after Obama announced Emanuel will be replaced by Pete Rouse as White House chief of staff in the East Room of the White House in Washington on October 1, 2010. File Photo by Roger L. Wollenberg/UPI | License Photo

H. Ross Perot attends the dedication ceremony for the new U.S. Air Force Memorial on October 14, 2006 in Arlington, Va. On October 1, 1992, Perot announced his candidacy for the presidency. He called his group the Reform Party. File Photo by Chip Somodevilla/UPI | License Photo

On October 1, 2017, a gunman on the 32nd floor of the Mandalay Bay Resort and Casino in Las Vegas opened fire on a crowd attending a country music festival outside, killing 58 people


IrO~2~ (see [Figure [4](#fig4){ref-type="fig"}](#fig4){ref-type="fig"}), which would explain the smaller electron donation from water to the metal and weaker bond in the former case.

Overall, the ability of (110) and (011) surfaces to induce dissociation of an interacting water molecule seems to be ultimately related to (i) the kind of octahedral distortion observed in the bulk of these materials (tetragonal elongation for TiO~2~ and tetragonal compression for RuO~2~ and IrO~2~) and (ii) the different nature of the vacant sites created (axial or equatorial) on these surfaces.

Adsorption of Water Monolayer {#sec2.3}
-----------------------------

Previous section has shown that the relative stability between the *mol* and *diss* adsorbed forms of water on the (110) and (011) surfaces of MO~2~ (M = Ti, Ru, and Ir) depends on the increase of water acidity upon adsorption andsimulation. Note that the frequency of the 2*mol*/2*diss* is 99.9% and only the 1*mol*/3*diss* arrangement appears in 0.1%. For IrO~2~, we observed a larger proton mobility. As predicted by static calculations, the main configuration is a fully dissociated monolayer (4*diss*) with an 84% frequency. Noticeably, there is a non-negligible frequency of the 1*mol*/3*diss* (11.4%) and of the 2*mol*/2*diss* (4.8%). This indicates that thermal effects disfavor deprotonation, because of the increase of the M--O~w~ distances, which reduces the water--surface interaction and thus the water acidity.

The (011) surface shows a larger proton mobility compared to the (110) one. For TiO~2~ and RuO~2~, most stable configurations (8*mol* and 4*mol*/4*diss*, respectively) obtained from static calculations remain the most frequent arrangement (94 and 72%). However, for IrO~2~, the most stable configuration (2*mol*/6*diss*) is


Finally, on (110)-IrO~2~, the main monolayer configuration is the fully dissociated one, whereas on (011)-IrO~2~, it exhibits a degree of dissociation that ranges from 50 to 75%. Overall, the present study shows that several effects, in addition to the intrinsic water adsorption, are responsible for the degree of dissociation of adsorbed water on MO~2~ (M = Ti, Ru, and Ir), IrO~2~ being the one more prone to induce dissociation.

Computational Details {#sec4}
=====================

Periodic boundary DFT calculations were carried out with the Vienna ab initio simulation package (VASP) code.^[@ref54],[@ref55]^ All calculations were performed with the GGA PBE functional^[@ref56]^ plus D2 Grimme's correction^[@ref57]^ for dispersion and using the projector augmented wave pseudopotentials^[@ref58],[@ref59]^ to describe ionic cores and valence electrons through a plane wave basis with a kinetic energy cutoff equal to 500needing council’s approval to move forward.

Both properties are rectangular in shape and were originally developed for residential purposes.

240 Holland St. West is located immediately east of Deer Run Crescent, and north of Harmony Circle. The property is around 1,328.5 sq. metres in area, with an existing one-storey residence.

210 Holland St. West is 1,793.0 sq. metres in size; the existing two-storey was built in 1895 and is currently listed on the Town’s Heritage Registry.

Through the ongoing discussion, a number of changes were made to both proposals.

At 210 Holland St. West, the proposed office space has been reduced from 1,679 sq. ft. to 1,221 sq. ft., and total building coverage from 35.7 percent to 34.9 percent. Other changes include an increase in building height from 15.1 metres to 16.57 metres,


Background
==========

Lentiviral vectors are efficient tools for gene transfer into various dividing and non-dividing target cells. They offer several advantages over other vectors, including stable integration into the host cell genome, lack of transfer of viral genes, and a relatively large capacity for therapeutic genes. A number of studies have demonstrated the ability of lentiviral vectors to achieve efficient and sustained transgene expression \[[@B1]-[@B6]\] and they have recently been approved for human clinical studies \[[@B7]\]. The majority of preclinical studies undertaken thus far have been conducted with the aim of transferring one therapeutic gene into target cells. However, many potential gene transfer applications require vectors that express more than one protein. These may include a therapeutic gene plus a selectable marker gene, multiple genes encoding different subunits of aare expressed as nanograms of p24 (mean ± SD) from 4 independent experiments. Statistical analysis was performed using analysis of variance and Tukey\'s studentized range test. No statistically significant difference in titer (p24) was observed between the vectors tested.

Bicistronic vectors
-------------------

We first compared the expression of MGMT and eGFP in cells transduced with bicistronic vectors with that seen in cells transduced with monocistronic vectors expressing either MGMT or eGFP alone. To do this, we transduced Hela and K562 cells with increasing MOI as judged by the p24 estimations. The relative levels of reporter gene expression seen post transduction may be a reflection of a number of variables including transduction efficiency, number of copies of integrated transgene, and efficiencies of transcription and translation. We therefore firstly examined the performance of


levels of MGMT protein. MGMT-2A-eGFP transduced cells produce MGMT protein with a 2A peptide attached to their C terminus, and this migrates differently from its wild-type counterpart. MGMT-2A-eGFP transduced cells also showed a very minor higher molecular weight band indicating the presence of uncleaved MGMT-2A-eGFP fusion protein (Figure [5A](#F5){ref-type="fig"}). We observed this minor fraction of uncleaved fusion protein only in MGMT-2A-eGFP transduced cells and not in other tricistronic vectors containing 2A. MGMT and MGMT-IRES-eGFP vector transduced cells showed a single band corresponding to the MGMT protein of the expected size (Figure [5A](#F5){ref-type="fig"}). Northern blot analysis of total RNA isolated from monocistronic and bicistronic virus transduced K562 cells showed vector-derived transcripts proportional to their MGMT and eGFP protein levels as detected by Western blot analysis (Figure [5A](#F5){ref-type="fig"} and [5B](#F5){ref-type="fig"}).

![(A).comparison. There was a lower efficiency of transduction of the tricistronic vectors compared to that of monocistronic (eGFP) or bicistronic vectors as assessed by the percentage of eGFP positive cells following transduction (Figure [7](#F7){ref-type="fig"}). When copy number was assessed by Q-PCR, it was evident that the mean proviral copy per cell was less for tricistronic vectors at a given level of p24, than for monocistronic MGMT and bicistronic vectors with the exception of monocistronic eGFP vector. When eGFP levels (MFI) were normalized to proviral copy number it was again clear that IRES-mediated eGFP expression was much less efficient than that from monocistronic or 2A based bicistronic vectors. The level of eGFP per proviral copy was progressively lower in tricistronic vectors and MGMT-2A-HOXB4-IRES-eGFP construct expressed lowest level (Figure [4A](#F4){ref-type="fig"},


in the co-expression of two transgenes than IRES based vectors. Indeed, co-expression mediated by the 2A motif was superior to internal ribosome entry across a range of different vector MOIs, and it is of import that this differential was maintained at a limiting copy number. Thus, 2A represents an attractive alternative to currently used systems for the co-expression of two proteins in lentiviral vectors.

A major advantage of using the 2A cleavage factor in the construction of multicistronic vectors is its small size compared to internal promoters or IRES sequences. Given the packaging constraints on lentiviral vectors, minimizing the size of sequences required to enable co-expression is important in maximizing the capacity for therapeutic sequences. In addition, efficient co-expression of both genes is ensured as we have shown inimportant that these are transported to the appropriate compartment of the cell where their action is required. As shown by the nuclear localization of HOXB4 and MGMT in our study, the addition of 2A sequences did not adversely affect the trafficking of these two proteins. Recently Szymczak et al \[[@B24]\] reported the construction of a multicistronic retroviral vector using multiple 2A cleavage factors or similar sequences with efficient coexpression of complete T cell receptor complex proteins. They showed that a 2A like peptide linked retroviral vector could be used to express all of the four CD3 proteins (CD3ε,γ,δ,ζ), appropriately localized to the membrane and that this restored T cell development in CD3 deficient mice. However in another recent report, mistargetting of second gene products was observed dependent on