people were registered to vote at a lower percentage rate than the remaining voters in the county; consequently, defendants have not proved underrepresentation of those minorities on the jury venire.
Defendants argue, however, that all those who reside in the areas with high minority concentrations, all of which are located in the core city or within the urban area of Sacramento County, constitute a cognizable class; defendants claim to have proved underrepresentation of this "class" by virtue of the fact that a lower percentage of such residents age 18 or over register to vote than in other areas of the county. We do not agree that a cognizable class can be established merely on the basis of common geographical location (People v. McDowell (1972) 27 Cal. App.3d 864, 875one of several means calculated to achieve the common goal. (People v. Manson, supra, 61 Cal. App.3d at pp. 155-156; People v. Cowan (1940) 38 Cal. App.2d 231, 239 [101 P.2d 125]; People v. Wilson (1926) 76 Cal. App. 688, 694 [245 P. 781]; People v. Schmidt (1917) 33 Cal. App. 426, 446 [165 P. 555].)
There is no merit in defendants' claim that the probative value of the conspiracy evidence was outweighed by its prejudicial effect. (Evid. Code, § 352.) The record demonstrates that the trial court considered at length defendants' objections on this basis at trial, and chose in its discretion to admit the evidence. (20) The trial court decision admitting evidence over the objection that it is more prejudicial than probative will not be disturbed on


Little had knocked another guard to the floor, stabbed him in the throat with a pencil and battered him repeatedly as the guard struggled to reach an alarm to summon help.
At trial defendants sought to exclude all testimony regarding their escape attempt, arguing the prejudicial effect of such evidence outweighs its probative value on the issue of consciousness of guilt. Defendants contend that since they were then being held in custody for other charges in addition to the Foster-Blackburn murder-assault (the other charges arose out of the shoot-out with Sgt. Duge in Contra Costa County), and since the escape attempt occurred almost 16 months after the Foster murder, an inference therefrom of consciousness of guilt could as well be ascribed to the Contra Costa County charges then pendingof a per se rule is that it is per se. This court is precluded from making the very determination which the majority undertakes. Moreover, because of the extremely limited circumstances under which a jury's deliberations may *850 be made of record (see, e.g., Silverhart v. Mount Zion Hospital (1971) 20 Cal. App.3d 1022 [98 Cal. Rptr. 187, 54 A.L.R.3d 250]) at best the majority may only infer that the Allen instruction had no effect. Indeed, an examination of the majority opinion demonstrates that very fact. For instance the majority observes, "The identity of that defendant was established circumstantially when the verdicts were returned in open court.... That these dates were not inaccurate can be inferred from the court's instruction...." (Italics added.)
Moreover, I cannot concur in the majority's


made by Julian and Federico on
July 20 was not effective to bind ECT.  Please confirm this with Sara and
Scott and make sure everyone is on board with this.  I am sure Scott was just
using the draft deal ticket Julian prepared and Julian used the date they
called rather than the date that Scott did the deal.

To: Brent Hendry/ENRON_DEVELOPMENT@ENRON_DEVELOPMENT
cc: Dale Neuner/HOU/ECT@ECT
Subject: Central Puerto S.A.

Brent,

One last question on the Central Puerto S.A. doc.  We currently have the
Trade Date as July 23, but the tickets we received say July 20th.  Is July
20th correct?

Thanks,
Joeonly 48 National Cancer Institute-designated Comprehensive Cancer Centers, a distinction that recognizes Moffitt's excellence in research, clinical trials, prevention and cancer control. Moffitt is the No. 6 cancer hospital in the nation and has been listed in U.S. News & World Report as one of the "Best Hospitals" for cancer care since 1999. Moffitt devotes more than 2.5 million square feet to research and patient care. Moffitt's expert nursing staff is recognized by the American Nurses Credentialing Center with Magnet® status, its highest distinction. With more than 5,600 team members, Moffitt has an economic impact in the state of $2.1 billion. For more information, call 1-888-MOFFITT (1-888-663-3488), visit MOFFITT.org, and follow the momentum on Facebook, Twitter and YouTube.


condos and land for sale, as well as new homes and apartment rentals.
Each listing is also available here on our web site through our listings search.
You can also order magazines for your local area to carry with you to find homes for sale.clock is installed in the gable. The risalit contains the main entrance at ground level, in the form of a circular arch, the distinguishing characteristic of Romanesque buildings. This form appears in all the ground floor windows and in the windows in the gables. On both sides of this central block are two symmetrical wings, which slightly protrude from the central block both at the front and at the rear. These have the same architectural style as the central block and have high gables.

Rowald took the Romanesque style elements from the architecture of existing medieval buildings in the old town of Hersfeld, for example from the ruins of the Romanesque abbey, without copying their individual elements (Gelnhausen station, which was also designed by Rowald, has a similar design).


which shares sequence similarity with other AMP from natural \[[@B42]\] or synthetic origin \[[@B43],[@B44]\]. It has activity against plant pathogenic fungi as well as several microorganisms of clinical relevance, including the yeast *Candida*and several dermatophytic fungi \[[@B45]\]. PAF26 at low micromolar (sub-inhibitory) concentrations has been recently shown to have cell penetrating properties in the mycelium and conidia of the filamentous plant pathogen *Penicillium digitatum*\[[@B46]\] and the model fungus *Neurospora crassa*(A. Muñoz and N. Read, unpublished observations). Contrary to melittin, PAF26 is less active against bacteria and is not haemolytic under assay conditions in which other peptides including melittin are \[[@B45]\].

We combined global analyses of transcriptomic changes upon exposure of *S. cerevisiae*to sub-lethal concentrations of either PAF26 or melittin with sensitivity tests of strains lacking genes identified by thewas assayed but no alteration on sensitivity to peptides was found (see details on Additional File [5](#S5){ref-type="supplementary-material"}).

PAF26 and related peptides are arginine-rich and penetratin-type peptides \[[@B46]\]. *BTN2*codes for a protein with protein binding activity involved in amino acid transport, pH and ion homeostasis and arginine uptake \[[@B59]\]. It was, together with *STE5*(see above), the gene with the highest repression common to both peptides (Figure [3](#F3){ref-type="fig"} and Additional File [2](#S2){ref-type="supplementary-material"}). However, neither the corresponding deletion strain nor the related Δ*btn1*\[[@B60]\] displayed significant differences regarding sensitivity to peptides (Figure [5C](#F5){ref-type="fig"}).

*HSC82*was used as a representative of the several heat shock proteins (HSP) that are markedly repressed by PAF26 and/or melittin such as *HSP78*, *HSP12*or *STI1*(Additional File [3](#S3){ref-type="supplementary-material"}). Indeed, the response to unfolded protein stress GO term was significantly repressed upon melittin


treatment (Additional File [4](#S4){ref-type="supplementary-material"}). *HSC82*was repressed by PAF26, and the corresponding deletion strain was selectively more resistant to PAF26 (Figure [5C](#F5){ref-type="fig"}).

Interaction of PAF26 with S. cerevisiae cells
---------------------------------------------

We have previously reported that PAF26 is capable to interact with and be internalized by the hyphal cells of the filamentous fungus *P. digitatum*at sub-inhibitory concentrations (0.3 μM) \[[@B46]\]. PAF26 is markedly less active against *S. cerevisiae*than towards *P. digitatum*\[[@B41]\] and, accordingly, although internalization of fluorescently labeled PAF26 into *S. cerevisiae*FY1679 could be demonstrated through confocal microscopy, 100-fold higher peptide concentrations (30 μM) were required (Figure [6A](#F6){ref-type="fig"}).

![**Fluorescence microscopy of *S. cerevisiae*exposed to FITC-PAF26**. **(A)**Internalization of FITC-PAF26 into *S. cerevisiae*FY1679 demonstrated by confocal fluorescence microscopy. Cells were exposed to 30 μM FITC-PAF26 for 30 min. Bright-field (A1) and fluorescence (A2) micrographs of thelabeled with the peptide. This latter result indicates that the higher resistance of these strains is not due to lack of interaction and/or internalization of the peptide.

![**Differential interaction of *S. cerevisiae*deletion mutants with FITC-PAF26**. Representative fluorescence micrographs of the parental BY4741 and *S. cerevisiae*deletion strains Δ*ssd1*, Δ*ecm33*, and Δ*arg1*, as indicated at the left. Optical and image acquisition settings were the same for each fluorophore and thus differences in fluorescence intensity among strains reflect real differences. Others details as in Figure 6B.](1471-2180-10-289-7){#F7}

![**Differential interaction of *S. cerevisiae*deletion mutants with FITC-PAF26**. Flow cytometry measurements of FITC-PAF26 binding to *S. cerevisiae*deletion mutants shown below as compared with the parental strain BY4741. Graph shows the percentage of fluorescence bound to cells after exposure of 20,000 cells to either 5 (upper panel) or


30 μM (lower panel) FITC-PAF26. Mean and SD from two replicas in each of two independent experiments are shown for each strain.](1471-2180-10-289-8){#F8}

Discussion and Conclusions
==========================

We have carried out a functional genomic approach on yeast to gain insight into the mechanism of two AMP that presumably have different modes of antifungal killing. Analogous reports have addressed the mode of action of distinct antifungal agents \[[@B35]-[@B38],[@B61],[@B62]\], including other AMP \[[@B30],[@B32],[@B33]\]. These latter studies on AMP used inhibitory concentrations and found an array of multifactorial effects, but could not distinguish those processes primary related to peptide mechanism from those secondarily derived from cell death. Since we have observed biological changes of *P. digitatum*after exposure to sub-inhibitory (sub-micromolar) concentrations of PAF26 that include peptide internalization \[[@B46]\], we decided to use non-inhibitory concentrations ofto, AMP in microorganisms \[[@B8]-[@B12]\]. We have also shown that PAF26 and melittin have common but also differential effects on yeast. Finally, a previously overlooked observation is that a significant part of the response relies on genes of unknown function, or with poorly informative GO terms associated to them.

A remarkable example of uncharacterized genes uncovered in our study is YLR162W, the only gene not related to ribosome biogenesis among the seven induced by melittin and repressed by PAF26 (Figure [2](#F2){ref-type="fig"}). It is a predicted gene of unknown function that codes for a small protein with potential transmembrane domains \[[@B49]\]. An independent study has shown that over expression of YLR162W confers resistance to the plant antimicrobial peptide MiAMP1 in a susceptible yeast strain \[[@B49]\]. Strikingly, our study indicates (in


This is believed to have an impact on age-related diseases.

US scientists conducting the research looked at the effect of omega-3 fatty acids on telomere shortening in 608 hospital out-patients with heart disease. At the start of the study, measurements were taken of the length of chromosomal telomeres in the patients' white blood cells. Blood levels of the two fish-derived omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were also measured.

The tests were carried out again after five years, and showed a clear correlation with omega-3 intake. Patients consuming the least omega-3 had the fastest rate of telomere shortening, while those in the top 25% of consumption levels had the slowest rate.

The scientists, led by Dr Ramin Farzaneh-Far of the University of California at San Francisco, wrotea third party is responsible for payment, the obligations must be in writing, signed, and preserved.b. Payment will be required in full by 5:00 pm 3 business days prior to the scheduled court proceedings.

PCA Resources, PA is an independent company that provides billing and administrative services to health care providers. All health care providers that use PCA are independent contractors and are not the agents or employees of PCA Resources, PA.
Please note that the information contained within this website is provided for informational and educational purposes only. The use of this website does not imply or establish any type of doctor/patient relationship. No diagnosis or treatment is being provided by the use of this website


// mkerrors.sh
// Code generated by the command above; see README.md. DO NOT EDIT.

// +build arm,darwin

// Created by cgo -godefs - DO NOT EDIT
// cgo -godefs -- _const.go

package unix

import "syscall"

const (
	AF_APPLETALK                      = 0x10
	AF_CCITT                          = 0xa
	AF_CHAOS                          = 0x5
	AF_CNT                     Q:

May HTTP server send a 400 response without waiting for the request body?

When my client is making a POST request containing a non-empty body to an HTTP server (IIS 7.0) the server responds with 400 without waiting for the whole request body being fully transmitted.
Can anyone point out where the HTTP standard describes this situation: premature response without waiting for the whole request being transmitted?
UPDATE:
in fact the server waits for the full message, the problem was in my code

A:

Looks like it "should" be reading it.  RFC 2616 states:

The presence of a message-body in a request is signaled by the
  inclusion of a Content-Length or Transfer-Encoding header field in the
  request's message-headers.

...and...

A server SHOULD read and forward a message-body on any request

Perhaps something else


all of them couldn’t lie.

Despite the winter chill, I could sense Vinod loosening his tie (he often wore ties, even in summer). In all those years at the paper, he was not used to being questioned like this. However, being a glib operator, he thanked me for calling him and said he would try and clear all my doubts.

My biggest worry at that point was that the following day, the graphic details would inflame people in other parts of Gujarat and India and spark more violence.

There was no point appealing to my line editor’s journalistic ethics or his concern – if any – for India’s image. The hole in the story that I had just discovered would not matter, when the deadline trumped everything. Plus, this was awhich was about to acquire a US-based software company. Here was a pocket-sized Indian company acquiring an American company that was four times bigger. Frankly, it was quite exciting to be able to write about the deal.

Since, I had zero experience in writing a corporate story, the corporate bureau head suggested, I contact Aruna (name changed) a seasoned corporate reporter. Aruna had recently joined BW after quitting her job at the Delhi-based business daily I mentioned above and had written extensively about LMH Systems. She was very nice to me and said I should speak directly to the owner of LMH Systems, who in her opinion was an extremely friendly guy and would provide me any information that I wanted about the deal.

Curiously, she revealed that she owned


The 12 Days of Site 87's Christmas

The 12 Days of Site-87's Christmas, by Wolf Expert.

On the First day of Christmas, 87 Gave to me…

Tristan Bailey started putting up the Christmas tree. He had drawn the short straw, and was tasked with putting up the tree this year, which had been bought from a new tree farm in town.

"Eya Bailey!" Agent Ewell walked in, stepping aside from the mistletoe cautiously. "Merry X-Mas!"

"Same to you, Ewell." Tristan awkwardly stood the tree up and frowned; despite the fact that it was fifteen feet tall, it neatly fit into the commons he had set it up in, which had only a ten-foot ceiling. "…remind me to get Sinclair or someone in botany to look at this."

"Noted," Ewell said, sipping on some eggnog.recover, but not before the Christmas Tree tore apart the entire site looking for the one who damaged it.

Chris ran all the way down to Multi-U, leaving the doors to the stairwells open on every level so that the tree would search the entire facility until it found him. He just hoped Dr. Sinclair was right about the tree wanting to get him after it took out Krampus, and as it turned out, she was.

He just didn't count on the tree being able to use the elevator. He gawked as the doors to the one on the Multi-U level opened, and a fifteen-foot-tall tree thing stepped out, the topper glowing bright red and green.

"I hate this job."

He started running, but he was out of breath from going down


pH in aqueous solution were obtained. The structures were assessed in three media with different pH values, and an accelerated decrease of their size was reported in an acidic medium; this behavior can be correlated with the increase of Zeta potential values, which indicates higher stability against the tendency to form clusters. Moreover, the accelerated degradation of polyether-urethanes in acidic medium indicates their potential to be used in oral drug administration.

Conflict of Interest {#sec1-6}
====================

The authors declare that there is no conflict of interest.
      {
            HttpClient httpclient = new DefaultHttpClient();
            HttpPost httppost = new HttpPost(site);

            try {
                 // Add your data
                List<NameValuePair> nameValuePairs = new ArrayList<NameValuePair>(2);
                nameValuePairs.add(new BasicNameValuePair("dateOfEventStart", startYear + "-" + startMonth + "-" + startDay));


 175
       (_From Stothard's_ 'Monumental Effigies')

   83. Effigy of bishop Marshall of Exeter, died 1206         177
       (_From Murray's_ 'Handbook to the Southern Cathedrals')

   84. Parsonage house of early thirteenth-century date at
       West Dean, Sussex                                      179
       (_From Hudson Turner's_ 'Domestic Architecture')

   85. Effigy of a knight in the Temple church, London,
              196
       (_From_ Cott. MS. Nero D. i. ff. 21 and 22 _b_)

   94. Barn of thirteenth-century date at Raunds,
       Northamptonshire                                       197
       (_From Hudson Turner's_ 'Domestic Architecture')

   95. A fight between armed and mounted knights of the time
       of Henry III.


of the state.
Though he was often a cruel oppressor of the wealthy personages who
lived in Rome itself, and whose rivalry he feared, he, for the most
part, sought to establish his power by giving justice to the provinces
which had once been conquered by Rome, but were now admitted to share
in the advantages of good government which the Empire had to give. One
consequence of the conquest of nations by Rome was that there was now
an end to cruel wars between hostile tribes. An army was stationed on
the frontier of the Empire to defend it against barbarian attacks. In
the interior the Roman peace, as it was called, prevailed, and there
was hardly any need of soldiers to keep order and to maintain
obedience.

16. =The Invasion of Aulus Plautius.= A.D. =43=.--One question which
each Emperorto the western edge of Hampshire
had thus been mastered by Saxons, others of the same stock, known as
East Saxons, seized upon the low coast to the north of the Thames.
From them the land was called Essex. Neither Saxons nor Jutes,
however, were as yet able to penetrate far up the valley of the
Thames, as the Roman settlement of London, surrounded by marshes,
still blocked the way.

6. =The Anglian Settlements.=--The coast-line to the north of the East
Saxons was seized at some unascertained dates by different groups of
Angles. The land between the Stour and the great fen which in those
days stretched far inland from the Wash was occupied by two of these
groups, known as the North folk and the South folk. They gave their
names to Norfolk and Suffolk, and at some later


another in
London. London was now again an important trading city, which, though
not in AEthelberht's own kingdom of Kent, formed part of the kingdom of
Essex, which was dependent on Kent. More than these three Sees
Augustine was unable to establish. An attempt to obtain the friendly
co-operation of the Welsh bishops broke down because Augustine
insisted on their adoption of Roman customs; and Lawrence, who
succeeded to the archbishopric after Augustine's death, could do no
more than his predecessor had done.

7. =Death of AEthelberht. 616.=--In =616= AEthelberht died. The
over-lordship of the kings of Kent ended with him, and Augustine's
church, which had largely depended upon his influence, very nearly
ended as well. Essex relapsed into heathenism, and it was only by
terrifying AEthelberht's son with the vengeance of St. Peter that
Lawrence kept him from relapsing also. Onhouse-carls, the constant
guard of picked troops which had been instituted by Cnut, and his
thegns, who, like the Norman barons, were bound to serve their lord
in war. The greater part of his force, however, was composed of the
peasants of the fyrd, and when September came they must needs be sent
home to attend to their harvest, which seems to have been late this
year. Scarcely were they gone when Harold received news that his
brother Tostig, angry with him for having consented to his deposition
from the North-humbrian earldom, had allied himself to Harold
Hardrada, the fierce sea-rover, who was king of Norway, and that the
two, with a mighty host, after wasting the Yorkshire coast, had sailed
up the Humber. The two Northern Earls, Eadwine and Morkere, were hard
pressed. Harold had not long before married


when evening came Harold Hardrada, and
Tostig himself, with the bulk of the invaders, had been slain. For the
last time an English king overthrew a foreign host in battle on
English soil.

[Illustration: A Norman ship. (From the Bayeux Tapestry.)]

[Illustration: Norman soldiers mounted. (From the Bayeux Tapestry.)]

23. =The Landing of William. 1066.=--Harold had shown what an English
king could do, who fought not for this or that part of the country,
but for all England. It was the lack of this national spirit in
Englishmen which caused his ruin. As Harold was feasting at York in
celebration of his victory, a messenger told him of the landing of the
Norman host at Pevensey. He had saved Eadwine and Morkere from
destruction, but Eadwine and Morkere gave him no help in return. He
had to hurry back to defendthemselves to be
the strongest, and were most inclined to throw off his yoke. The chief
feature of the reigns of William and of his successors for three
generations was the struggle which scarcely ever ceased between the
Norman barons on the one side, and the king supported by the English
and the clergy on the other. It was to the advantage of the king that
he had not to contend against the whole of the Normans. Normans with
small estates clung for support, like their English neighbours, to the
crown. The first of many risings of the barons took place in =1075=.
Roger, Earl of Hereford, in spite of William's prohibition, gave his
sister in marriage to Ralph of Wader, Earl of Norfolk, who, though of
English birth on his father's side, had fought for William at Senlac,
and


   (1) The Emperor Henry V. = Matilda = (2) Geoffrey Plantagenet
                                                |
                                              HENRY II.
                   the bulk of the people as they were to the
king, Henry was able to strengthen himself by winning the affections
of the people. Feudality in itself was only a method of owning land;
but it was always threatening to pass into a method of government. In
France the great feudal lords ruled their own territories with very
little regard for the wishes of the king, and the smaller feudal lords
had their own courts in which they hanged and imprisoned their
villeins. In Stephen's time an attempt had been made to introduce this
system into England, with evil consequences both to king and people.
Before the Conquest great landowners had often received permission
from the king to exercise criminal jurisdiction in the Manor Courts on
their own estates, whilst the vast extent of their landed property
gave them a


whom
he could persuade to help him. On this a number of knights from South
Wales, of whom the most important was Richard de Clare, afterwards
known as Strongbow, flocked across the Irish Sea (=1169--1170=). They
fought and conquered, and Strongbow, who married Dermot's daughter,
gave himself the title of Earl of Leinster. The rule of these knights
was a rule of cruelty and violence, and, what was more, it might well
become dangerous to Henry himself. If feudal nobles established
themselves in Ireland, they might soon be holding out a hand to help
the feudal nobles who were Henry's worst enemies in England. When
Henry landed in Ireland in =1171= he set himself to restore order. The
Irish welcomed him because he alone could bridle the invaders, and the
invaders submitted to him because they dared not resist him.according to the ideas of his age, he should have been safe, as
every church was considered to be a sanctuary in which no criminal
could be arrested. Hubert Walter, however, came in person to seize
him, set the church on fire, and had him dragged out. William
Longbeard was first stabbed, and then tried and hanged, and for the
time the rich tradesmen had their way against the poorer artisans.

[Illustration: Hall of Oakham Castle, Rutland: built about 1185.]

13. =Architectural Changes.=--Even in the most flourishing towns the
houses were still mostly of wood or rubble covered with thatch, and
only here and there was to be found a house of stone. So slight,
indeed, were the ordinary buildings, that it was provided by the
Assize of Clarendon that the houses of certain offenders should be
carried outside the


the
situation was very simple. John was to obey the Pope, and all John's
subjects were to obey John. A Papal legate arrived in England, fixed
the sum which John was to pay to the clergy, and refused to listen to
the complaints of those who thought themselves defrauded.

14. =The Battle of Bouvines. 1214.=--In =1214= John succeeded in
carrying his barons and their vassals across the sea. With one army he
landed at Rochelle, and recovered what had been lost to him on the
south of the Loire, but failed to make any permanent conquests to the
north of that river. Another army, under John's illegitimate brother,
the Earl of Salisbury, joined the Emperor Otto in an attack on Philip
from the north. The united force of Germans and English was, however,
routed by Philip at Bouvines, in Flanders.Peter des Roches. The
barons, led now by the king's brother, Richard of Cornwall,
remonstrated when they met in the Great Council, which was gradually
acquiring the right of granting fresh taxes, though all reference to
that right was dropped out of all editions of the Great Charter issued
in the reign of Henry. For some time they granted the money which
Henry continually asked for, coupling, however, with their grant the
demand that Henry should confirm the Charter. The king never refused
to confirm it. He had no difficulty in making promises, but he never
troubled himself to keep those which he had made.

[Illustration: A ship in the reign of Henry III.]

10. =The Early Career of Simon de Montfort. 1231--1243.=--Strangely
enough, Simon de Montfort, the man who was to be the chief opponent of
Henry and his foreign


     Eleanor = Simon de
     1216-1272  | Provence     Earl of Cornwall             Montfort
                |            and King of the Romans
         -------------
         |           |
     EDWARD I.    Edmund, titular King of Sicily
     1272-1307

CHAPTER XIV.

EDWARD I. AND EDWARD II.

EDWARD I., =1272--1307.= EDWARD II., =1307--1327.=

LEADING DATES

the resistance of Ghent against the Count of Flanders, was
defeated and slain at Roosebeke by Charles VI., the young king of
France. In =1383= an English expedition led by Henry Spencer, Bishop
of Norwich, under the pretext of a crusade against the French as the
followers of the Pope of Avignon, ended in complete failure, and
Flanders, the great purchaser of English wool, fell under the control
of France. In =1385= Richard, indeed, invaded Scotland, ravaged the
country and burnt Edinburgh, though without producing any permanent
result. In =1386= a French fleet and army was gathered at Sluys, and
an invasion of England was threatened.

2. =Richard's growing Unpopularity. 1385--1386.=--When the king
returned from Scotland in =1385= he made a large creation of peers. He
raised his two younger uncles to the Dukedoms of York and Gloucester;
his Chancellor, Michael


de la Pole, to the earldom of Suffolk, and his
favourite, Robert de Vere, Earl of Oxford, to the marquisate of
Dublin, making him not long afterwards Duke of Ireland. Suffolk was an
able and apparently an honest administrator, who upheld the king's
prerogative against the encroachments of Parliament. Oxford was a gay
and heedless companion of Richard's pleasures, who encouraged him in
unnecessary expense, and thereby provoked to resistance those who
might have put up with an extension of the royal authority. That
resistance, however, was to a great extent due to causes not of
Richard's own making. Though the French in =1386= abandoned their
attempt at invasion, the preparations to resist them had been costly,
and Englishmen were in an unreasonable mood. Things, they said, had
not gone so in the days of Edward III. A cry forher on the way,
but in the second battle of St. Albans--fought on February 17--was
driven back, leaving the king behind him.

13. =The Battle of Towton and the Coronation of Edward IV.
1461.=--With a civilised army at her back, Margaret might have won her
way into London, and established her authority, at least for a time.
Her unbridled supporters celebrated their victory by robbery and rape,
and Margaret was unable to lead them forward. The Londoners steeled
their hearts against her. Edward was marching to their help, and on
February 25 he entered London. The men of the neighbouring counties
flocked in to his support. On March 2 the crown was offered to him at
Clerkenwell by such lords as happened to be in London. On his
presenting himself to the multitude in Westminster Hall, he was
greeted with shouts


was back in England, landing at Ravenspur, where Henry IV. had
landed in =1399=. Like Henry IV., he lyingly declared that he had come
merely to claim his duchy and estates. Like Henry IV., too, he found a
supporter in an Earl of Northumberland, who was this time the Percy
who, Lancastrian as he was, had been restored by Edward to his earldom
at the expense of Montague. Clarence, too--false, fleeting, perjured
Clarence, as Shakspere truly calls him--had offered to betray Warwick.
Edward gathered a sufficient force to march unassailed to London,
where he was enthusiastically received. Taking with him the
unfortunate Henry he won a complete victory at Barnet. The battle was
fought in a dense fog, and was decided by a panic caused amongst
Warwick's men through the firing of one of their divisions into
another. Warwick andin the event of that king's dethronement.

13. =The Intercursus Magnus. 1496.=--The danger of a Scottish invasion
made Henry anxious to be on good terms with his neighbours. Maximilian
had become Emperor in =1493= upon his father's death. In the
Netherlands, however, his influence had declined, as his son, the
young Archduke Philip, was now growing up, and claimed actually to
rule the country which he had inherited from his mother, Mary of
Burgundy (see p. 337), his father having merely the right of
administering the government of it till he himself came of age. It was
therefore with Philip, and not with Maximilian, that Henry concluded,
in =1496=, a treaty known as the _Intercursus Magnus_, for the
encouragement of trade between England and the Netherlands, each
party engaging at the same time to give no shelter to each other's
rebels.

14.


introduced into England, 129;
    decline of asceticism amongst, 167;
    are fined by John, 179.

  Clare, Gilbert de, _see_ Gloucester, Earl of.

  Clare, Richard de, _see_ Strongbow.

  Clare, Richard de, _see_ Gloucester, Earl of.

  Clarence, Lionel, Duke of, sent to Ireland, 265.

  Clarence, George, Duke of, brother of Edward IV., created a
      duke, 329;
    marries Warwick's daughter, and quarrels with Edward IV., 332;
    put to death, 336.

  Clarence, Thomas, Duke of, brother of Henry IV., killed at
    Bauge, 306.

  Clarendon, the Constitutions of, 144;
    the assize of, 146.

  Claudius, the Emperor, plans the conquest of Britain, 13.

 the throne, 337;
    lodged in the Tower, 340;
    deposed, 341;
    murdered, 342.

  Edward, Prince of Wales, _see_ Black Prince, the.

  Edward, Prince of Wales, son of Henry VI., birth of, 323;
    slain at Tewkesbury, 334.

  Edward, Prince of Wales, son of Richard III., death of, 342.

  Eleanor of Aquitaine marries Henry II., 137;
    imprisonment of, 155;
    takes part with John against Arthur, 174.

  Eleanor of Castile, wife of Edward I., accompanies her husband
      on the Crusade, 204;
    death of, 214.

  Eleanor of Provence marries Henry III., 192.

  Eleanor, sister of Henry III., marries Simon de


 Lords, House of, names the Duke of York Protector, 324;
    decides on his claim to the crown, 329.

  Lose-coat Field, 332.

  Lothian, cession of, to Scotland, 68, 84.

  Louis VI., king of France, makes war with Henry I., 129.

  Louis VII., king of France, divorces Eleanor of Aquitaine, 137;
    supports young Henry's rebellion, 153;
    takes part in the second Crusade, 157.

  Louis (afterwards Louis VIII., king of France) opposes John, 184;
    expelled from England, 185.

  Louis IX., Saint, king of France, surrenders territory to
      Henry III., 200;
    mediates between Henry III. and the barons, _ib._

  Louis X., king of France,with Archbishop Thomas, 204.

  Siward, Earl of North-humberland, 84, 87.

  Slaves preserved alive at the English conquest, 30.

  Sluys, battle of, 239.

  Somerset, Welsh driven out of, 53.

  Somerset, Edmund Beaufort, second Duke of, commands in Normandy, 320;
    supported by Henry VI., 323;
    slain at St. Albans, 324.

  Somerset, Edmund Beaufort, fourth Duke of, executed, 334.

  Somerset, John Beaufort, first Duke of, commands in France, 317;
    kept from court by Suffolk, 318;
    dies, 320.

  Somerset, Henry Beaufort, third Duke of, executed, 331.

  Sorbiodunum (_Old Sarum_), the stronghold of Ambrosius, 34.

  South Saxons, the, first conquests of, 27;
    destroy Anderida, 28.

  Spain, union


October 24, 2012

Researchers’ Discovery Could Pave Way To Faster, Smaller Electronics

by editor

University of California, Davis, researchers for the first time have looked inside gallium manganese arsenide, a type of material known as a "dilute magnetic semiconductor" that could open up an entirely new class of faster, smaller devices based on an emerging field known as “spintronics.”

Materials of this type might be used to read and write digital information not by using the electron´s charge, as is the case with today´s electronic devices, but by using its "spin."

Understanding the magnetic behavior of atoms is key to designing spintronics materials that could operate at room temperature, an essential property for applications.

The new study used a novel technique, hard X-ray angle-resolved photoemission spectroscopy or HARPES, developed by Charles Fadley, distinguished professorof physics at UC Davis and the Lawrence Berkeley National Lab, and recent UC Davis doctoral graduate Alexander Gray, together with colleagues at LBNL and in Germany and Japan.

The research represents the first major application of the HARPES technique, which was first described in a proof-of-principle paper by Gray, Fadley and colleagues last year.

The latest work was published Oct. 14 in the journal Nature Materials.

Angle-resolved photoemission spectroscopy uses Einstein's famous photoelectric effect to study materials. If you bombard atoms with light particles – photons – you knock out electrons, known as photoelectrons, which fly out at precise angles, energies and spins depending on the structure of the material.

For many years researchers have used "soft" or low-energy X-rays as the photon source, but the technique can look only at


connected) nilpotent Lie group $\G^\sharp$ of step $d$.

Given a group $\G$, a sequence $A:\Z\to\G$ will be called a polynomial sequence if $A(0)=1$ and $D^{k_0}A\equiv 1$ for some $k_0\geq 1$, where, by definition, $$D^0A(n)=A(n),\qquad D^{k+1}A(n)=D^kA(n)^{-1}D^kA(n+1),\qquad n\in\mathbb{Z}.$$

In this paper we consider only the easier problem of $L^2$ boundedness of the discrete singular Radon transforms. To formulate our main result, let $K:\mathbb{R}\to\mathbb{R}$ be a Calderon–Zygmund kernel, i.e. a $C^1$ function satisfying $$\label{CalZyg}
\sup_{t\in\mathbb{R}}[(1+|t|)|K(t)|+(1+|t|)^2|K'(t)|]\leq 1,\qquad\sup_{N\geq 0}\Big|\int_{-N}^NK(t)\,dt\Big|\leq 1.$$ The main theorem we prove in this paper is the following:

\[Main1\] Assume $\G$ is a discrete nilpotent group of step $2$, $K$ is a Calderon–Zygmund kernel, and $A:\mathbb{Z}\to\G$ is a polynomial sequence. For any (compactly supported) function $f:\G\to\mathbb{C}$ let $$(Hf)(g)=\sum_{n\in\Z}K(n)f(A^{-1}(n)\cdot g),\qquad g\in\G.$$ Then $$\|Hf\|_{L^2(\G)}\lesssim\|f\|_{L^2(\G)}.$$

We describe now some of the main ideas in the proof of theand describe the operators $H_{j_1}^\ast H_{k_1}\ldots H_{j_r}^\ast H_{k_r}$ and $H_{j_1} H_{k_1}^\ast\ldots H_{j_r} H_{k_r}^\ast$, for integers $j_1,k_1,\ldots j_r,k_r\in[J(1-\kappa),J]$. For $r\geq r(d)$ large enough we prove in Proposition \[majarcs\] that the kernels of these operators are sums of more standard oscillatory singular integral kernels, similar to (arising from “major arcs”), and negligible errors (arising from “minor arcs”). The bounds on these error terms rely on Proposition \[minarcs\] and are delicate in our situation, due to the complicated structure of the polynomials that arise as a result of multiplication in the group $\mathbb{G}_0$.

Section \[proofthm\] contains the proof of Theorem \[Main2\], i.e. the proof of the bounds in , along the line described above.

In section \[oscil\] we prove estimates for trigonometric sums and integrals, using a variant of the Weyl method developed


the center of the group $\G^\#$.

Assume that $$\label{tra4}
A(n)=\Big(\sum_{i=1}^{d_3}\al_{i}n^i,\sum_{i=1}^{d_3}\beta_{i}n^i\Big),\qquad \alpha_1,\ldots,\alpha_{d_3}\in\mathbb{R}^{d_1},\, \beta_1,\ldots,\beta_{d_3}\in\mathbb{R}^{d_2}.$$ We define $$T(g_l)=\begin{cases}
(\alpha_l,\gamma_l)&\text{ if }l\in\{1,\ldots,d_3\},\\
(0,\gamma_l)&\text{ if }l\in\{d_3+1,\ldots,d\},
\end{cases}$$ for some vectors $\gamma_1,\ldots,\gamma_d\in \mathbb{R}^{d_2}$ to be fixed, and extend $T$ as a group morphism from $\G_0\to\G^\#$. Since $$A_0(n)=g_1^n\cdot\ldots\cdot g_d^{n^d},$$ it follows that $$T(A_0(n))=(\sum_{i=1}^{d_3}\alpha_in^i,\sum_{i=1}^d\gamma_in^i+\sum_{i=1}^{2d_3}\rho_in^i),$$ for some coefficients $\rho_1,\ldots\rho_{2d_3}$ that depend only on $(\alpha_i)_{i\in\{1,\ldots,d_3\}}$ and the bilinear form $R$. The desired identity $T(A_0(n))=A(n)$ can be arranged by choosing the vectors $\gamma_1,\ldots,\gamma_d$ appropriately.

Assume now that we could prove the following particular case of Theorem \[Main1\]:

\[Main2\] For any $d\geq 1$, $R\geq 1$, and $F:\mathbb{G}_0\to\mathbb{C}$ let $$(H^R_0F)(g_0)=\sum_{|n|\leq R}K(n)F(A_0(n)^{-1}\cdot g_0),$$ where $A_0:\mathbb{Z}\to\G_0$ is as in and $K$ is as in . Then $$\|H^R_0F\|_{L^2(\G_0)}\lesssim_d \|F\|_{L^2(\G_0)}\qquad\text{ uniformly in }R.$$

It is not hard to see that Theorem \[Main2\] would imply Theorem \[Main1\]. This follows from the standard transference principle,American Spitfire Pilot

This is probably one of the best WWII film clips out there. Stored for 61 years in two suitcases of 16mm home movies that were inherited by filmaker Willliam Lorton from his great uncle who served as a Flight Surgeon. Those suitcases contained 3 hours of war footage that included a compelling crash landing of a Spitfire in 1944.

Filmed in a 2005 interview with the now 83 year old pilot and seeing the expression on his face when he realizes it is him in the cockpit, is something you somehow won't soon

forget. At 18 years old, he was all alone, behind enemy lines, with no guns, no escort, and he gladly did it.

They just don't make them like that anymore. It was truly the greatest generation


study) showed a statistically significant association between marital status, level of education, family history of breast cancer, and mammography, which partly accords with our findings; this study also reported that the married females examined had better knowledge regarding mammography than did the single females.\[[@ref31]\] A study conducted in Italy showed a positive association between higher levels of education and mammogram uptake, which again contrasts with our findings.\[[@ref25]\] Further, in this Italy-based study, after comparing the occupational levels of women and their acceptance of mammograms, women with intermediate and high occupational levels were found to be more likely to undergo breast-cancer screening, with women in the highest occupational levels is most likely to undergo cervical cancer screening; this again contrasts with our findings. In addition, compared to more advantagedWHY IS IT FLOODING?

1994 Isuzu Trooper • 175,000 miles

1994 Isuzu Trooper 3.2LSOHC 4door, AutoTrans, has New injectors(6), Plugs(6) & wires, ECU, coils(3), Crank Sensor, Timing belt, water pump, radiator, O2 sensor, Speed Sensor, Idle Air Control, Pressure Regulator, Ignition control module, fuel filter, pvc, Air Intake Temperature sensor. I had all the stuff replaces before daughter headed off to College and was driving fine, after 4000 miles trooper just died while driving down road.
I replaced fuel pump, ignition switch, and EMC. When I turn, the key I can hear fuel injectors spray but will not start due to flooding (it does have spark). Sometimes it will start for about 2 sec then floods out. Fuel pressure gauge shows 39-40lbs. What else could it be? I have replaced so


 if is_prime(n) and num %n==0:
            num=num/n
            primes.append(n)
            while num%n ==0:
                num=num/n
                primes.append(n)

    return(primes)

A:

Correctness
1 is not a prime factor:
>>> find_prime_factors(25)
[5, 5, 1]

Performance
Primality testing is expensive.  You call is_prime() twice on every iteration of the main loop of find_prime_factors().  Furthermore, is_prime() performs trial division in much the same way that find_prime_factors() does, resulting in redundantcondition $F_i(0)=0$. Loosely, each $F_i$ corresponds to the cumulative distribution of $p_i$ under the null. Above, we have taken the supremum to cover the case where the null hypothesis is composite: in that situation, each $F_i$ is adjusted according to the least favorable configuration within the null $H_{0,i}$.

Here are some conditions on $\mathcal{F}$ that will be useful to compare some of the studied procedures (these conditions are [*not*]{} assumed in our results unless explicitly mentioned): $$\begin{aligned}
&F_{i}(t)\leq t , \:\: t\in[0,1],\:\:1\leq i \leq m, \label{equ-sousunif}\\
&F_{i}(t)= t , \:\: t\in[0,1],\:\:1\leq i \leq m \label{equ-unif}.\end{aligned}$$ Condition ensures that the $p$-values have marginals stochastically lower-bounded by a uniform variable under the null, called a [*super-uniform*]{} distribution in the sequel. This is the classical setting which is used in most of the work


dealing with FDR controlling theory, see, e.g., [@BenjaminiHochberg95]. Condition is more restrictive: if each null hypothesis is a singleton, it is equivalent to the $p$-values having uniform marginals under the null.

Discrete and continuous modelling {#sec:discretecont}
---------------------------------

In order to describe the overall support of $p$-value distributions we assume one of the two following situations to be at hand throughout the paper (except in Section \[sec:TheoreticalResults\] which is written in a more general manner):

-   Continuous case: for all $i \in\{1,\dots,m\}$, $F_i$ is continuous. In that case, we let $\mathcal{A}_i=[0,1]$, $1\leq i \leq m$ and $\mathcal{A}=\cup_{i=1}^m \mathcal{A}_i=[0,1]$ is the overall $p$-value support.

-   Discrete case: each $p$-value $p_i$ (both under the null and alternative) takes values in some finite set $\mathcal{A}_i =\{a_{i,k}, 0\leq k \leq K_i\}$, where $K_i\geq 0$ andhypotheses. More formally, for some procedure $R$ rejecting the $i$-th hypothesis if $p_i\leq \hat{t}(X)$ (for some threshold $\hat{t}(X)$), we let

$$\label{eq:FDR}
{\textnormal{FDR}}(R,P) = {\mathbf{E}}_{X \sim P}\left[\frac{\sum_{i\in{\mathcal{H}}_0(P)} {{{\mathbf}{1}\{p_i\leq \hat{t}(X)\}}} }{1\vee \sum_{i=1}^m {{{\mathbf}{1}\{p_i\leq \hat{t}(X)\}}} }\right],\:\: P\in\mathcal{P}.$$

The main contribution of this work is to propose procedures that control the FDR at a prescribed level $\alpha$ and that incorporate the knowledge of the $F_i$’s in a way that increases the number of discoveries.

Procedures {#sec:Methods}
==========

In this section we briefly review some existing methods for FDR control and introduce our new procedures.

Existing methods
----------------

We use the following methods as starting points for constructing new procedures.

-   : the seminal procedure proposed in [@BenjaminiHochberg95], corresponding to the step-up procedure ${{\mathbf{SU}}}(\tau)$, with critical values $\tau_k=\alpha k/m$, $1\leq k \leq m$;

-   : an adaptive version of the


Figure \[fig:FbarPlotsHellerForPaper\]). This entails that \[Heyse\] can substantially improve \[BH\] (see Figure \[fig:CritConstants\]).

While \[Heyse\] incorporates the knowledge of the $F_i$’s in a natural way (see also Remark \[Rem:bayes\] below), it is not correctly calibrated for a rigorous FDR control: as shown in [@Heller2012; @Doehler2016], it fails to control the FDR in general. We propose suitable modifications of \[Heyse\] in the next sections.

\[Rem:bayes\] We claim that \[Heyse\] corresponds to a suitable empirical Bayes procedure. To see this, consider the “binomial example" of Section \[sec:discretecont\], but assume now that the counts $n_1,\dots,n_m$ are observed from a sample $N_1,\dots, N_m$ i.i.d. of a priori distribution $\nu$. Unconditionally, the $p$-values $p_i$, $i\in{\mathcal{H}}_0$, are thus i.i.d. with c.d.f. $
\bar{F}_0=\sum_{n\geq 0} \nu(\{n\}) F_{0,n},
$ where $F_{0,n}$ is the c.d.f. jumping at each $x_{k,n}=2^{-n} \sum_{j=0}^{k-1} {n \choose j}$ with $F_{0,n}(x_{k,n})=x_{k,n}$,values are considerably larger than their respective classical counterparts. In \[subsec:NewMethods\] we mentioned that the correction factor $1- F_i(\tau_m)$, introduced for guaranteeing FDR control of \[DBH-SU\], may lead to a procedure which is more conservative than \[BH\]. However, Figure \[fig:CritConstants\] shows that – at least for the data sets considered here – this risk is by far compensated by the benefit of taking discreteness adequately into account.

Simulation study {#sec:simu}
================

We now investigate the power of the procedures from the previous section in a simulation study similar to those described in [@Gilbert05], [@Heller2012] and [@Doehler2016]. Again, we focus on comparing the performance of the new discrete procedures to \[BH\].

Simulated Scenarios
-------------------

We simulate a two-sample problem in which a vector of $m$ independent binary responses (“adverse events") is observed for each subject


new discrete procedures are considerably more powerful than their classical counterparts and perform roughly similarly for small and intermediate proportions of alternatives. When the proportion of alternatives is large, the benefit of using adaptive procedures – especially the \[A-DBH-SU\] procedure – is clearly visible in Figure \[fig:FDPvsModifiedFDPAverageProportionRejections\_25\].

Conclusion and discussion
=========================

In this paper, we provided new bounds for the FDR of step-up and step-down procedures that use discrete test statistics. This allowed to define a new class of multiple testing procedures that provably control the FDR while they incorporated the discreteness of the tests statistics in a convenient way. We have shown that our approach can be seen as correcting and improving the approach of [@Heyse2011]: while it ensures a theoretical control, it can also make more rejections when the# This file is a minimal clang-format sublime-integration. To install:
# - Change 'binary' if clang-format is not on the path (see below).
# - Put this file into your sublime Packages directory, e.g. on Linux:
#     ~/.config/sublime-text-2/Packages/User/clang-format-sublime.py
# - Add a key binding:
#     { "keys": ["ctrl+shift+c"], "command": "clang_format" },
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from __future__ import absolute_import, division, print_function
import sublime
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# Change this to the full path if clang-format is not


of hatred and bile on social media. The question is, why did so many scholars, especially feminists, express one sentiment behind closed doors and another out in the open? Why were so many others afraid to say anything in public?

For those lucky readers who didn’t follow the nasty attacks on social media, a bit of background is in order. To put it all too simply, in her Hypatia article, Tuvel claimed that the very public cases of Rachel Dolezal’s transracial transition and Caitlyn Jenner’s transgender transition operate according to a similar logic when it comes to thinking about identity and identity politics. Tuvel argued in favor of both transgender and transracial identities, as well as for a more fluid conception of identity more generally. In subsequent responses toproperty as $t\to\infty$: either $h(t)\to\infty$ and $u\to1$ (spreading case), or $h(t)\to h_\infty$ with $h_\infty\leq \pi/2$, and $u\to 0$ (vanishing case). Moreover, it was also proved that there is a constant $k_0>0$ such that $h(t)$ behaves like a straight line $k_0t$ for large time when spreading happens, where $k_0$ is called the asymptotic speed of spread (spreading speed for short), which is the unique value of $c$ such that the following nonlinear semi-line problem is solvable: $$\left\{
\begin{array}{ll}
q'' - cq'+q(1-q)=0,\ \ q'(z)>0, & z>0,\\
q(0)=0,\ \ q(\infty)=1, \ \ \mu q'(0)=c.
\end{array}
\right.$$ Later on, Du and Lou [@DuLou] obtained a rather complete characterization on the asymptotic behavior of solutions for with some general nonlinear terms. For further related work on free boundary problems, we refer to [@DuGuo; @DGP; @DMZ; @W1] and the


references therein.

Motivated by the above works, we consider the protection zone, where the evolution of the species is governed by the monostable nonlinear terms, but the species growth obeys strong Allee effect out of the protection zone and the expanding front is determined by a free boundary. Our model is described by the following forms $$\label{p}
\left\{
\begin{array}{ll}
u_t = u_{xx} + f(u), &  t>0, 0<x<L,\\
u_t = u_{xx} + g(u), &  t>0, L<x<h(t),\\
u_x(t, 0)=0= u(t,h(t)), & t>0,\\
h'(t)=-\mu u_x(t,h(t)),& t>0,\\
u(t, L-0)= u(t, L+0), & t>0,\\
u_x(t, L-0)= u_x(t, L+0), & t>0,\\
h(0)=h_0>L,\ u(0,x)=u_0(x)\geq 0, & x\in [0,h_0],
\end{array}
\right.$$ where $f$ is a monostable nonlinearity satisfying , and $g$ is a bistable nonlinearity satisfying and . It follows from the system that the protection is $[0,L]$. Furthermore, we assume that

[**[(H)]{}**]{}  The functions $f,\,g$ are [*globallyLipschitz*]{} and $g(u)<f(u)\ \mbox{ for all } 0 < u < 1$.

The initial function $u_0$ belongs to $ \mathscr {X}(h_0)$ for some $h_0>L$, where $$\label{def:X}
\begin{array}{ll}
\mathscr {X}(h_0):= \big\{ \phi \in C^1 ([0,h_0]):
\phi'(0)=\phi (h_0)=0,\;
\phi(x)>0 \ \mbox{in } (0,h_0)\big\}.
\end{array}$$ For any given $h_0>L$ and $u_0 \in \mathscr {X}(h_0)$, The (classical) solution of on the time-interval $[0,T]$ we mean $(u(t,x), h(t))$ satisfying $$u\in C^{1,2}((0,T]\times([0,h(t)]/\{L\}))\cap C^{\alpha/2,1+\alpha}((0, T]\times[0,h(t)])
\ \ \mbox{and }\ h\in C^1 ([0,T]).$$ In the rest of the paper, the solution may also be denoted by $(u(t,x; u_0), h(t; u_0))$, or simply $(u, h)$ depending on the context.

In this paper, we are going to employ the Schauder fixed point theorem to establish the local existence of solutions to , and prove the uniqueness, then extend the solutions to all time. The solution $u$


  Transition happens when $\sigma\in[\sigma_*,\sigma^*];$

    -   Spreading happens when $\sigma>\sigma^*$.

-   (Medium-sized protection zone case) Assume that $L_*<L< \max\{L^*,\ L_{**}\}$.

    -   If $L_*<L<L^*$ and $L^* < L_{**}$, then there exist $\sigma_*,\ \sigma^*\in[0,\infty)$ with $\sigma_*\leq\sigma^*$ such that the following trichotomy holds:

        -   Vanishing happens when $0<\sigma\leq \sigma_*$;

        -   Transition happens when $\sigma\in(\sigma_*,\sigma^*]$;

        -   Spreading happens when $\sigma>\sigma^*$.

        In addition, when $h_0< R^*(L)$, then $\sigma_*>0$; when $h_0\geq R^*(L)$, then $\sigma_*=0$, where $R^*(L)$ is given in Lemma \[lem:1ei2\].

    -   Ifplay an important role. It is well known that admits a unique solution $(c^*, q_{c^*})$ [@DuLou]. We call [*$q_{c^*}$ a semi-wave with speed $c^*$*]{}. Based on the semi-wave, we can construct suitable super solution and subsolutions to deduce the following result on the asymptotic spreading speeds and profiles of spreading solutions of .

\[thm:profile of spreading sol\] Assume that [**[(H)]{}**]{} holds and that spreading happens for a solution $(u, h)$ of problem . Let $(c^*, q_{c^*})$ be the unique solution of . Then we have $$\label{HWt1}
\lim_{t\to\infty} h'(t) =c^*,$$ $$\label{WHt1}
\lim\limits_{t\to\infty} \| u(t,\cdot)- q_{c^*}(h(t) -\cdot)\| _{L^\infty ( [0, h(t)])}=0.$$

We are now interested in the effect of structure of protection zone on the dynamics. For sake of simplicity, we consider the situation that a protection zone with the same length $2L$ is


find $X_0>0$ large such that there exists $K_0>0$ satisfying $$\label{eq:qc1}
q_{c^*}(z)\geq 1-K_0 e^{-\gamma z}\ \ \mbox{for }  z\geq X_0.$$ Choosing $0<\delta_1 <\frac{1}{2}\min\{\gamma c^*,-g'(1)\}$, it follows from [**[(H)]{}**]{} that there is $\varepsilon>0$ such that $$\label{fuzhu3}
f'(v),\ g'(v) \leq -\delta_1 \    \mbox{ for } \ v\in[1-\varepsilon ,1+\varepsilon].$$

Let $v(t)$ be the solution of $v_t=F(v)$ with initial value $v(0)=\|u_0\|_\infty +1$, where $$F(v)=\max\{f(v),\ g(v)\}.$$ Due to $F(v)<0$ for $v>1$, the function $v(t)$ decreases to $1$ as $t\to \infty$. Hence, for $\varepsilon>0$ in , there exists $t_0>0$ large such that $1<v(t)<1+\varepsilon$ for $t \geq t_0$. By we have $v_t = F(v) \leq \delta_1 (1-v)$ for $t\geq t_0$. Clearly $v(t)$ is an upper solution of , and so $$\label{Vtoto1}
u(t,x) \leq  v (t)\leq 1+ M_0  e^{-\delta_1 t}\ \ \ \mbox{ for }\
t\geq t_0,\ 0\leq x\leq h(t),$$ with $M_0:= \varepsilon e^{\delta_1 t_0}$. Take $T' >t_0$ large such that $$\label{equ:ee1}
h(t)\geq 2L\ \mbox{ and }\ M_0 e^{-\delta_1t}< \varepsilon /2\ \mbox{ for }\ t\geq T'.$$ Since $q_{c^*}(z)\to 1$ as $z\to\infty$, we can find $X >X_0$ large such that, with $M'=2M_0$, $$\label{U1a1}
(1+M'e^{-\delta_1 T'  })q_{c^*}(z)\geq 1+ M_0 e^{-\delta_1 T'}
\ \mbox{ for }  \ z\geq X.$$

Now we construct a finer upper solution $(\bar{u}, \bar{h} )$ to as follows: $$\begin{aligned}
& \bar{h}(t): =c^*t+ h (T')+ K M'(e^{-\delta_1 T'}-e^{-\delta_1 t})+X+2L \ \
\mbox{ for } t\geq T',\\
& \bar{u}(t,x):=(1+M'e^{-\delta_1 t})q_{c^*}(\bar{h}(t)-x)\  \ \mbox{ for } t\geq T',\ 2L\leq x \leq \bar{h}(t),\end{aligned}$$ where $K$ is a positive constant to be determined below. Clearly, for all $t\geq T'$, we have $\bar{u} (t, \bar{h}(t))=0$, and $$\begin{aligned}
-\mu \bar{u} _x(t,\bar{h} (t))& = & \mu(1+M'e^{-\delta_1


t})q'_{c^*}(0)=(1+M'e^{-\delta_1 t})c^*, \\
& < & c^*+M' K \delta_1 e^{-\delta_1 t} = \bar{h} '(t),\end{aligned}$$ if we choose $K$ with $K\delta_1 > c^*$. By the definition of $\bar{h}$ we have $h (T')<\bar{h}(T')$. It follows from - that for $x\in[2L, h (T')]$, $$\begin{aligned}
\bar{u} (T',x) &  = & (1+M'e^{-\delta_1 T'})q_{c^*}(c^*T'+h (T')+X+2L -x) \\
& \geq & 1+ M_0 e^{-\delta_1 T'} \geq  u(T',x),\end{aligned}$$ and for $t\geq T'$, $$\begin{aligned}
\bar{u} (t , 2L) &  \geq & (1+M'e^{-\delta_1 t})q_{c^*}(c^*t+X) \\
&\geq & (1+M'e^{-\delta_1 t})(1-K_0 e^{-\gamma (c^*t+X)})\\
& \geq & 1+ 2M_0 e^{ - \delta_1 t }-(1+\varepsilon)K_0 e^{-\gamma (c^*t+X)}\\
& \geq & 1+ M_0 e^{-\delta_1 t} \geq  u(t ,2L),\end{aligned}$$ by the fact that for $\delta_1\leq \frac{\gamma c^*}{2}$, due to $X\gg 1$ and $T'\gg 1$, then for $t\geq T'$, $$M_0 e^{ - \delta_1 t }-(1+\varepsilon)K_0 e^{-\gamma (c^*t+X)}\geq M_0L_2)$. Clearly, $\hat{\lambda}_1=0$ if $L_2-L_1=\frac{\pi}{\sqrt{f'(0)}}$. It follows from the comparison principle that $\tilde{\lambda}_1^R(L)<0$ when $L\geq \frac{\pi}{\sqrt{f'(0)}}$. This further implies that $\tilde{R}^*(L)< \frac{\pi}{\sqrt{f'(0)}}$ for $L\geq \frac{\pi}{\sqrt{f'(0)}}$.

\(iii) Let us consider the continuous function $$\tilde{\mathcal{J}}(L):=\tilde{R}^*(L)-L.$$ According to the above discussion we know that $\tilde{\mathcal{J}}(L)$ is decreasing and continuous with respect to $L>\tilde{L}_*$. This, together with , yields that $$\lim_{L\to \tilde{L}_*+0}\tilde{\mathcal{J}}(L)=+\infty,\ \ \ \tilde{\mathcal{J}}(\frac{\pi}{\sqrt{f'(0)}})<0.$$ Thus there exists a unique $\tilde{L}_{**}\in(\tilde{L}_*,\frac{\pi}{\sqrt{f'(0)}})$ such that $\tilde{\mathcal{J}}(L_{**})=0$. Thanks to the monotonicity of $\tilde{\mathcal{J}}(L)$ in $L$, we can derive all the other assertions of the lemma.

With the help of Lemmas \[lem:1eigenvaluemp2\] and \[lem:s1ei2\], one can use a similar argument to that of Theorem \[thm:dybe\] (with slight modifications) to prove Theorem \[thm:dybe1\]. Thus all the details are omitted here.

[123456]{}

W.C. Allee, Animal aggregations: a study in general sociology, University


a copy of the GNU General Public License
 * along with this program; if not, write to the Free Software
 * Foundation, Inc., 59 Temple Place, Suite 330, Boston, MA  02111-1307  USA
 */

package org.gudy.azureus2.ui.swt.config;

import org.eclipse.swt.SWT;
import org.eclipse.swt.widgets.Button;
import org.eclipse.swt.widgets.Event;

/**
 * @author Olivier
 *
 */
public class ExclusiveSelectionActionPerformer implements IAdditionalActionPerformer{

  boolean selected = false;

  Button[] buttons;

  public ExclusiveSelectionActionPerformer(Button[] buttons) {
    this.buttons = buttons;
  }

  /* (non-Javadoc)
   * @see org.gudy.azureus2.ui.swt.AdditionalActionPerformer#performAction()
   */
  public void performAction() {
    if(buttons == null)
      return;
    if(!selected)
      return;
    for(int i = 0 ; i < buttons.length ; i++) {
              Noella Mbolle Ejede Ejede, a native and citizen of

Cameroon,   petitions      for   review       of    an    order      of   the     Board    of

Immigration      Appeals     (Board)     dismissing           her    appeal      from     the

Immigration Judge’s order finding her asylum application to be

untimely    and     denying


F.3d 353,

358-59 (4th Cir. 2009).          Because Ejede’s asylum application was

found to be untimely by the agency, we lack jurisdiction to

review the merits of her asylum claim.

            Next, Ejede disputes the conclusion that she failed to

qualify for the relief of withholding of removal.                              “Withholding

of removal is available under 8 U.S.C. § 1231(b)(3) if the alien

shows that it is more likely than not that her life or freedom

would be threatened in the country of removal because of her

   Hereditary essential myoclonus in a large Norwegian family.
We examined 56 members of a large Norwegian family with hereditary essential myoclonus, affecting mainly the neck and upper parts of the body, and inherited in an autosomal-dominant pattern. We observed definite myoclonus in nine individuals, probable myoclonus in one, and possible myoclonus in one. There were two other living members who had a history compatible with myoclonus but who had developed a permanent remission, so we did not observe the movements, and two who had involuntary movements only with stress. Writing usually increased the myoclonus in the neck and trunk, but did not produce myoclonus in the arm used for writing. Having a conversation with an individual who was aware of being watched would also usually increase the myoclonus. Alcohol


the point of being able to determine the types of stress directly from the plant’s response to them. Their signaling response includes the production of what are known as volatile organic compounds (VOCs) that are able to both send signals to the rest of the cells and also defend directly against the stress, such as how some VOCs are antioxidants and are produced when free radical oxidation stress is being applied.

For salinity stress, a strong diversity of VOC responses are activated, including classes like green leaf volatiles (GLVs), monoterpenes, sesquiterpenes, short-chained oxygenated VOCs, and many more. We’ve discussed before how rice farms, due to the growing conditions of rice within water sources themselves, are highly sensitive to changes in salinity in the water. While efforts are ongoing todenote the microcanonical ensemble state, and later in this paper we will also use “PE” to denote the primary excited state. It was argued in [@Lu:2017tbo; @Dong:2018lsk] that the above results for microcanonical ensemble state also apply to the primary excited state as long as $\ell < L/2$. Note that, the primary excited state is a pure state so that $S_\PE^{(n)}(\ell)=S_\PE^{(n)}(L-\ell)$ relating the short and long interval ones, and the short interval expansion has been obtained in [@Lashkari:2016vgj; @Lin:2016dxa; @He:2017vyf; @He:2017txy]. Rényi entropy in canonical ensemble state for all three scales of $\ell$ have been obtained in [@Calabrese:2004eu; @Chen:2017ahf] by field theory method. However, Rényi entropy in microcanonical ensemble haven’t been explored before. This is one of the concrete results of our paper. Combining all the results, we


entropy in the thermodynamic limit \[SceM\] S\_[,]{}\^[(n)]{}() = + . The medium interval refined Rényi entropy is \[tdSceM\] S\_[,]{}\^[(n)]{}() = + . Comparing (\[tdSceM\]) with the holographic result in [@Dong:2018lsk], i.e. $\td S_{\CE,\rM}^{(n)}(\ell)$ in (\[ScenMSmeMnD\]), we find an extra term, i.e. the first term on the RHS of (\[tdSceM\]). Holographically, the refined Rényi entropy is given by the area of a codimension-2 cosmic brane homologous to the interval $A$ in a backreacted bulk geometry, which is denoted by $\mB_n(\b,A)$ in [@Dong:2018lsk]. The second term on the RHS of (\[tdSceM\]), is the contribution from the part of the cosmic brane parallel to the black hole horizon, and the first term is the part extending along the radial direction of the bulk geometry. For the second term to dominate theRHS of (\[tdSceM\]), we need \[req1\] . This is consistent with the validity regime of the result in [@Dong:2018lsk] \[req2\] . Note that for a medium interval case, by construction $L$ are at the same scale as $\ell$, i.e., $\ell\sim L$ so that in the thermodynamic limit we have $\ell/\b \gg 1$, $L/\b \gg 1$. The requirements (\[req1\]) and (\[req2\]) are equivalent for a medium interval in the thermodynamic limit. For the validity of (\[SceM\]) and (\[tdSceM\]), we do not require (\[req1\]) or (\[req2\]). The results (\[SceM\]) and (\[tdSceM\]) are generalizations of the results in [@Dong:2018lsk] with a larger validity regime.

Due to the aforementioned regions of validity for the short and long interval formulas (\[SceS\]) and (\[SceL\]), we can infer that the medium interval formula (\[SceL\]) should also


its mechanism for generic isolated quantum systems*, [*Nature* [**452**]{} (2008) 854](http://dx.doi.org/10.1038/nature06838), \[[[0708.1324]{}](https://arxiv.org/abs/0708.1324)\].

L. D’Alessio, Y. Kafri, A. Polkovnikov and M. Rigol, *[From quantum chaos and eigenstate thermalization to statistical mechanics and thermodynamics]{}*, [*Adv. Phys.* [**65**]{} (2016) 239–362](http://dx.doi.org/10.1080/00018732.2016.1198134), \[[[1509.06411]{}](https://arxiv.org/abs/1509.06411)\]. N. Lashkari, A. Dymarsky and H. Liu, *[Eigenstate Thermalization Hypothesis in Conformal Field Theory]{}*, [*J. Stat. Mech.* [**1803**]{} (2018) 033101](http://dx.doi.org/10.1088/1742-5468/aab020), \[[[1610.00302]{}](https://arxiv.org/abs/1610.00302)\]. A. Dymarsky, N. Lashkari and H. Liu, *[Subsystem eigenstate thermalization hypothesis]{}*, [*Phys. Rev.* [**E97**]{} (2018) 012140](http://dx.doi.org/10.1103/PhysRevE.97.012140), \[[[1611.08764]{}](https://arxiv.org/abs/1611.08764)\]. N. Lashkari, A. Dymarsky and H. Liu, *[Universality of Quantum Information in Chaotic CFTs]{}*, [*JHEP* [**03**]{} (2018) 070](http://dx.doi.org/10.1007/JHEP03(2018)070), \[[[ 1710.10458]{}](https://arxiv.org/abs/1710.10458)\]. S. W. Hawking, *[Particle creation by black holes]{}*, [*Commun. Math. Phys.* [**43**]{} (1975) 199–220](http://dx.doi.org/10.1007/BF02345020). S. W. Hawking, *[Breakdown of Predictability in Gravitational Collapse]{}*, [*Phys. Rev.* [**D14**]{} (1976) 2460–2473](http://dx.doi.org/10.1103/PhysRevD.14.2460). J. M. Maldacena, *[The Large N limit of superconformal field theories and supergravity]{}*, [*Adv. Theor. Math. Phys.* [**2**]{} (1998) 231–252](http://dx.doi.org/10.4310/ATMP.1998.v2.n2.a1), \[[[hep-th/9711200]{}](https://arxiv.org/abs/hep-th/9711200)\].Q:

Foregin Key problems android SQLite

I would like to ask what is the problem in my code that my foregin key is not working. Primary key is working well.
I have 3 table, created in this way: (some words can be in polish, cause I am doing it to pass subject but these words are not importnat( I guess))
private static final String TABLE_CONTACTS = "Kontrahenci";
private static final String KEY_ID = "id";
private static final String KEY_NAME = "imie";
private static final String KEY_SURNAME = "nazwisko";
private static final String KEY_STREET = "ulica";
private static final String KEY_NRB = "numerBudynku";
private static final String KEY_NRL = "numerLokalu";
private static final String KEY_KOD = "KodPocztowy";
private static final String KEY_CITY = "Miejscowosc";
private static final String KEY_NIP = "NIP";
private static final String KEY_TEL = "Telefon";
private static final String KEY_EMAIL


Antinuclear autoantibodies are more prevalent in COPD in association with low body mass index but not with smoking history.
Chronic obstructive pulmonary disease (COPD) is associated with a higher prevalence of antinuclear autoantibodies (ANAs). However, a significant subgroup of patients is ANA negative. It remains to be determined which patient groups carry autoantibodies. The association of smoking behaviour, disease status, gender, age and body mass index (BMI) with the presence of autoantibodies in the serum was determined in 124 patients with COPD and 108 non-COPD control subjects. In addition, the role of B cells in autoantibody generation in COPD was investigated by sequencing the antibody repertoire of B cells in the lungs of patients with COPD and of ex-smoking and never-smoking control subjects. Patients with COPD had a significantlyheavily emphasized heaven, hell, and other death wish ideas. Memento mori acts as a popular reminder of mortality, that all humans end up dead.

I don’t mean to suggest that Christianity is obsessed with death, but let’s talk about the danse macabre for a minute. Many European churches from the middle ages have representations of the Grim Reaper, of dancing bones, of skulls. Why?

The Dance of Death (1493)

In part, it’s because death is the one constant that binds us. And our knowledge of the Middle Ages (e.g. the Plague) suggest that death was constantly on the doorstep.

That Christian influence trickled down into art. Countless Golden Age artists used symbolic objects (e.g. skulls, guttering candles) in their portraits. For example, here’s a portrait by Clara Peeters.

Just a cat eating a


Prostate cancer vaccines in combination with additional treatment modalities.
Immunotherapy has been investigated in both preclinical studies and clinical trials as a new therapy for prostate cancer. Vaccines, including those that utilize dendritic cells, viruses, or DNA, immunize against prostate-specific antigen and prostatic acid phosphatase. The vaccines have long been studied as monotherapy for the cancer, but increasingly more trials have been initiated in combination with other modalities. These include radiation, chemotherapy, and androgen deprivation therapy. This review describes and discusses the various combinations of vaccine immunotherapies.often appeared and spoken before the American Israel Public Affairs Committee (AIPAC) annual summit. At his most recent appearance this past spring his keynote speech included “I stand with Israel, proudly and unapologetically. So, when someone accuses American supporters of Israel of dual loyalty, I say: accuse me. I am part of a large, bipartisan coalition in Congress supporting Israel. I tell Israel’s detractors: accuse us.” Well, he got that right. He and many other congressmen do suffer from dual or even singular loyalty when it comes to Israel.

In 2007 Hoyer notably called out fellow Democrat Representative Jim Moran for stating correctly that AIPAC “has pushed (the Iraq) war from the beginning.” Hoyer called the statement “factually inaccurate,” which was not the case. He is a supporter of


including troglitazone and pioglitazone, have been shown to have anti-tumor effect when administered in combination with paclitaxel and cisplatin in NSCLC. Paclitaxel and cisplatin themselves lead to enhanced expression of PPARG, and the administration of PPARG ligands in combination has been shown to be more effective ([@B48]). PPARG can exhibit anti-tumor effects both by PPARG dependent and independent pathways ([@B26]; [@B14]; [@B9]). Drugs like γ tocopherol have shown to upregulate PPARG level in SW 480 colon cancer cell line attributing to the anti-cancer effect which is dependent on PPARG ([@B11]). Prostaglandin of the J series including 15deoxy ^12,14^PGJ~2~ (PPARG ligand) induces apoptosis in breast cancer cell line by binding to PPRE response (through binding to PPARG) which suggests that peroxisomal proliferator receptor element (PPRE) mediated signaling is essentiallythe sub G1 population went up to 5.5%, which further increased to 15.83% in the combination of PPARG with radiation clearly suggesting the potential of this combination against resistant lung cancer cells ([Figure 3A](#F3){ref-type="fig"}). The effect of PPARG transfection on different phases of cell cycle has been shown in [Supplementary Figure S1](#SM1){ref-type="supplementary-material"}. To determine the overall effect of different experimental groups on the cell viability, their ability to take up PI (an indication of dead cells) was determined. Radiation alone led to 6.79% increase in PI positive cells, whereas PPARG and combination of PPARG with radiation led to 12.64 and 22.01% increase in PI positive population, respectively, further supporting our earlier observations ([Figure 3B](#F3){ref-type="fig"}). Vector alone did not have much effect on PI uptake indicating that the effect


Effect of PPAR Is Inversely Related to the TP53 Pathway
------------------------------------------------------------------------

Since TP53 is an important modulator of apoptosis and is known to get activated in radiation induced DNA damage conditions ([@B59]), it became important to investigate the role of TP53 in PPARG mediated apoptosis. Surprisingly, the expression of TP53 reduced significantly after PPARG transfection in A549 cells ([Figure 5A](#F5){ref-type="fig"}). To confirm this, the levels of downstream targets of TP53 including CDKN1A and CDKN1B were explored ([Figure 5](#F5){ref-type="fig"}). CDKN1A is the direct target of TP53 mediated transcription. TP53 translocates to the nucleus and dimerises to mediate the transcription of CDKN1A by binding to its promoter region ([@B3]). Although TP53 also regulates CDKN1B, it may also be regulated through the PI3K pathway ([@B31]). Similar to TP53, levels of CDKN1A were foundgets induced in a PPARG dependent manner ([Figure 9D](#F9){ref-type="fig"}). There was a significant reduction in apoptosis in PPARG+radiation combination under PPARG knockdown conditions indicating that the apoptosis induced is PPARG mediated.

![Apoptosis induction in A549 cell line is PPARG dependent. **(A)** Knockdown of PPARG was done using siRNA specific to PPARG. Effect of PPARG knockdown on A549 cells was determined by various assays. PPARG was co-transfected along with PPARG siRNA and the complete knockdown of PPARG was evaluated using Western blotting. The protein level has been normalized with loading control. **(B)** Cell survival was studied 48 h post-transfection The error bar represents standard deviation in which ^∗^*P* \< 0.05, ^∗∗^*P* \< 0.01, and ^∗∗∗^*P* \< 0.001. The experiment was done in triplicate (*n* = 3) two times **(C)** Metabolic


of Genomics and Integrated Biology). We would also like to thank Dr. Ravi Soni and Dr. Anant Narayan Bhatt for their technical help during the experiments. SK would like to thank Akanksha Mani Tripathi for her support during microscopy and DRDO for providing fellowship. KS thanks DRDO for funding. AN acknowledges DBT, CSIR, and DU for providing research grants.

Supplementary Material
======================

The Supplementary Material for this article can be found online at: <https://www.frontiersin.org/articles/10.3389/fgene.2019.00554/full#supplementary-material>

######

PPARG treatment led to accumulation of cells in S phase which on treatment with PPARG+radiation move toward cell death. Various phases of cell cycle after different treatment has been depicted. A549 cells were transfected with PPARG (PPARG (TT) and irradiated 24 h post-transfection, which is 48 h after transfection. These samples which included CONTROL, RAD CONTROL (5           $1,065.00"

Summons was issued and served upon the defendant, under the terms of which an answer or other responsive pleading was to be served and filed on or before July 14, 1981. On the defendant's motion, the court entered its order granting it leave to file an answer out of time on July 24, 1981, and further directing that, within 15 days of the date of July 30, 1981, the defendant "file for the court's inspection the documents upon which it relies (to) show that its security interest vested prior to November 6, 1978 . . ."
When that order was not complied with, the court entered its order on August 24, 1981, granting the lien avoidance by default


F.2d 1193 (10th Cir. 1981), a lien cannot constitutionally be avoided.
The court has, through its orders of inquiry entered since the filing of the plaintiffs' motion to set aside the judgment, established that the balance currently due to the defendant is greater than the $1,065.00 of value of the collateral which has been stipulated to. It has further negatived the possibility that the security interest of July 14, 1978, is a purchase money security interest. Accordingly, because payments made by the plaintiffs have at no time paid the balance due below the $1,065 level,[2] it is appropriate for the prior judgment granting redemption for payment of that sum to remain in effect.
For the foregoing reasons, for the separate and independent reasons that the motion to vacate or set"Ummo 206 calling Earth." "Reply please." "Contact made." "Kerian Werner, surgeon, killed in war action." "Maleva Kerstein, doctor of biochemistry, killed in automobile accident." "Both persons have required characteristics and have been incarnated by our envoy." "They will contact you." "Remember success of mission depends on exploiting to the full the superstitions prevalent among the earth creatures." "The first objective is Blaustat Fairgrounds." "This is the world we have to conquer." "Its inhabitants are weak, slaves to their own passions and uncertainties." "Couldn't we use atom bombs?" "Of course, we could even explode their nuclear arsenal." "But we need the planet intact." "How much time do we have?" "Very little - our planet is now nearly at freezing point and we still haven't figured out yet how to


and read your future in your unseeing eye." "Love, passion, jealousy." "Remember what I told you." "The passions and weaknesses from which our race is immune." "Are the very ones to which the earth creatures are prey - sex and love." "Have no fear, my beautiful assistant is also a qualified nurse." "Ask him to tell your fortune." "Promise to tell his, tonight." "Who will be the first to try?" "Don't worry, she'll take care of you." "Ah here's someone - a lady who is not afraid to know the truth." "Beautiful women are like powerful magnets - we shall use them to attract scientists, generals, statesmen and their vital secrets." "So far, we've nothing to go on - no fingerprints, no known enemies." "Looks like the worka werewolf." "You are fully responsible for him." "No human power can withstand the contagion of the vampire." "Or the mummy, a murderer who obeys only the Pharaos of Egypt." "Or the Frankenstein monster." "We shall make thousands of them, and turn them loose on the races of this planet." "I experienced a strange sensation, when I touched Waldemar's body." "The same thing I felt when I was together with Farsi." "Is he a man or a monster?" "Both - the eternal dilemma of mankind." "Good and evil - the paradox." "Looks like the work of a wild animal." "Four woman have vanished, and two murders in a peaceful town where nothing ever happens." "Everyone expects results from us, and most of all, the Mayor..." "Come in." "New


"Not one of these recent murder cases has been solved by your department." "Furthermore, this Dr. Varnoff..." "Mr. Mayor?" "One of my best men, Inspector Tobermann, is in charge of these cases and I'm just expecting a report from him." "Gentlemen, I have some information." "Which I have concealed until now for personal reasons." "And as you realize, I have more interest in this matter, than any of you since it is my daughter who has disappeared." "Judge Sternberg, we're doing everything within our power to find your daughter, assuming her absence isn't of her own volition." "What is this information?" "Why haven't you divulged it?" "Because nobody would believe me." "Gentlemen, you recall Waldemar Daninsky?" "Well, he's still alive." "I've seen him and talked to him." "Hewas involved with what's happening at the monastery." "Mr. Gluck, we haven't time to waste on legal technicalities." "All right - we'll pay a visit to that monastery, and anybody who wants to come along will obey my orders, is that understood?" "Hurry." "The full moon is not going to wait." "Where's Ilsa?" "I don't know." "Maybe in the cellars." "Ilsa!" "Ilsa!" "Ilsa!" "Are you going to arrest Dr. Varnoff?" "No comment." "Ilsa!" "Impossible." "We're no longer able to control them." "Frankenstein's monster!" "Take up positions surrounding the monaste..." "Dr. Varnoff." "If you do not leave the monastery immediately, we shall enter by force, if neccecary." "Stay back." "Stay back please." "Watch the exits." "Keep back there." "We're trapped." "When those two clouds of gas meet..." "It's pointless


to try to escape, Dr. Varnoff." "You must pay the price for failure." "Do you have any useful information for us?" "Yes." "We won't be able to destroy them." "The passion which we believed to be their weakness, is really what makes them strong." "Stronger perhaps than their nuclear weapons." "Can we eliminate these feelings?" "Perhaps, but would life then be worth living?" "We must survive." "We shall try other methods." "Anything else?" "Yes, I'm entirely responsible for the failure." "Can she be spared?" "You are forgetting that Dr. Kerstein has ceased to live on earth." "While there are men willing to sacrifice themselves for others, nothing will ever destroy us."strain (Type I), a highly virulent strain for mice, was used to challenge immunized BALB/c mice. Tachyzoites of the RH strain was maintained in liquid nitrogen and recovered routinely by intraperitoneal passage in Kunming mice in our laboratory according to the method previously described \[[@B37]\]. Tachyzoites of *T. gondii* were harvested from the peritoneal fluid of Kunming mice that had been intraperitoneally infected three days earlier. Soluble tachyzoite antigen (STAg) was obtained from RH strain tachyzoites as previously described \[[@B38]\]. Briefly, parasites obtained from the peritoneal exudates were washed three times by centrifugation, then suspended in sterile phosphate buffered saline (PBS) and sonicated for three 10 min periods at 60 w/s. The toxoplasma sonicate was centrifuged at 2100 × g for 15 min. The supernatant, containing soluble tachyzoite antigens (STAg), was harvested


groups after*T. gondii*acute challenge.** Each mouse was challenged intraperitoneally with 1 × 10^3^ *T. gondii* RH strain tachyzoites at two weeks after the last immunization. Survival times were monitored daily after the challenge. Each group was composed of nine mice.](1471-2334-13-494-5){#F5}

Discussion
==========

In the present study, we have compared the protective efficacy of different immunization strategies in BALB/c mice. Our results suggested that all the vaccination regimens can trigger a significantly higher level of humoral and cellular immune responses than the control groups injected with PBS or pEGFP. Especially, the regime with DNA vaccine priming followed by peptide boosting elicited significantly high levels of IgG, IgG2a and IFN-γ secretion, which is an effective approach to provide protection against lethal *T. gondii* infection.

Immunotherapy may be one of the most promising approaches to prevent the infectionresponse elicited by vaccine in mice was complex, and it is not sufficient to merely analyze a Th1-biased response. In the future study, evaluating the efficiency of vaccine from different aspects could be a new and promising strategy. In addition, many factors, such as *T. gondii* strain, the dose of inoculum, the inoculation route, and the mouse strain, might hinder an efficient evaluation of *T. gondii* vaccines \[[@B58]\]. It is known that intraperitoneal infection with tachyzoites is an unnatural route though it can easily be performed. Thus, in some immunization studies, oral challenge, the natural route of infection, were made with cystogenic strains \[[@B59]\]. Therefore, in our study, many parameters might hinder the effective evaluation of protective immunity. The current study is the lack of a full and


Brooklyn – spread out over four days in early July, with performances from black punk bands, film screenings, and an impromptu picnic at Fort Greene Park. The festival has since grown at an exponential rate, with annual festivals not only in Brooklyn, but also Atlanta, London, Paris, and Johannesburg, drawing tens of thousands of attendees.

Facebook Twitter Pinterest James Spooner. Photograph: Courtesy of James Spooner

Though it could be viewed as a successful model of a global black-owned and black-centered music festival, Afropunk has faced criticisms from the grassroots POC punk community, particularly for its sponsorships from companies like Red Bull and Coors Light; and for promoting fewer punk rock headliners in favor of popular R&B or hip hop acts like Lauryn Hill, Lenny Kravitz, Ice Cube, and Tyler, the2018 festival and is planning its next event for August 2020.

“Even though we’re including everyone that’s a person of color, we are prioritizing black people,” Shawnté says. “Because we still need to be seen and to be prioritized and to be acknowledged.”

Facebook Twitter Pinterest Maafa performing at the Break Free Fest Photograph: Farrah Skeiky

In 2017, independent black and brown punk festivals launched in three major cities: Deep Cuts in New Orleans; Break Free Fest in Philadelphia; and Decolonize Fest in London, a multi-day festival organized by the London-based collective DIY Diaspora Punx. Decolonize Fest held its third annual festival in June 2019. Break Free Fest also hosted its third festival on Memorial Day weekend 2019.

The Break Free Fest organizer Scout Cartagena explains what she sees as the driving


we denote respectively by $\P_g$ and $\E_g$ the probability and expectation under the assumption that the common density of each $X_i$ in the i.i.d. sample $(X_1, \ldots, X_n)$ is $g$. In the particular case where the $ X_1, \ldots, X_n$ are i.i.d. with common density $\phi_d$, which is associated to the null hypothesis $H_0$, we write $\P_0:=\P_{\phi_d}$ and $\E_0:=\E_{\phi_d}$. A testing procedure $\Psi$ denotes a measurable function of the sample $\underline{X}$, having values in $\lbrace 0,1\rbrace$. By convention, we reject (resp. do not reject) $H_0$ is $\Psi=1$ (resp. $\Psi=0$). Given $\alpha \in ]0,1[$, the test $\Psi$ is said to be of level $\alpha$ if $\P_{0}(\Psi=1) \leq \alpha$. In such a case, we write $\Psi =\Psi_\alpha$.

Lower bounds {#s:lb}
============

Lower bound for the alternative class $\F_2[M]$ {#ss:lb1}
-----------------------------------------------

The non asymptotic minimax separationif $\rho <  \rho^\star$, $$\underset{\Psi_\alpha}{\inf}\ \underset{\underset{\varepsilon \|\mu\|_\infty \geq \rho }{f\in \mathcal F_\infty[M]}}{\sup}\ \P_f(\Psi_\alpha=0) >\beta.$$ This implies that $$\underline{\rho}(\mathcal F_\infty[M],\alpha,\beta) \geq \rho^\star.$$

Theorem \[thm:lb2\] indicates that the detection condition on the parameters $(\varepsilon,\mu)$ is affected by the change of the reference norm. In particular, the dependency w.r.t. the dimension of the data is in this context of order $\sqrt{\ln(d)}$ which makes in some sense the detection problem easier than the one considered in Section \[ss:lb1\].

Upper bounds {#s:ub}
============

In Section \[s:lb\], we have proposed lower bounds on the separation region for the testing problem (\[eq:pb\]). In particular, we have proved that in some specific cases, related to the value of the parameters $(\varepsilon,\mu)$, testing is impossible, i.e. every level-$\alpha$ tests will be associated to a second kind error greater than a


a correction of the level of each individual test $\mathds{1}_{\lbrace Z^{(v_n)}_{(n-k+1)}> q_{\alpha,k} \rbrace}$ that guarantees a final first kind error of level $\alpha$. The quantiles $q_{\alpha,k}$ can be explicitly computed. We refer to [@LLM2014] for more details regarding the construction of this testing procedure.

Theorem \[thm:ub2\] enhances the performances of the test $\Psi_{2,\alpha}$.

\[thm:ub2\] Let $\alpha, \beta \in]0,1[$ be fixed. Then, the testing procedure $\Psi_{2,\alpha}$ introduced in (\[eq:test2\]) is of level $\alpha$. Moreover, there exists a positive constant $C(\alpha,\beta,M)$ depending only on $\alpha$, $\beta$ and $M$ such that $$\underset{\underset{\varepsilon \|\mu\| \geq \rho}{f\in \F_2[M]}}{\sup}\
    \P_{f}\left(\Psi_{2,\alpha}  = 0 \right) \leq \beta,$$ for all $\rho \in \R_+^*$ such that $$\rho \geq \rho^\dagger := C(\alpha,\beta,M) \frac{d^{ 1/4}}{\sqrt n}\sqrt{\ln \ln n}$$ provided that $${n} \varepsilon \geq C(\alpha,\beta,M).$$

The main conclusion of\kappa_n \right).\end{aligned}$$ At this step, remark that the variable $\bar A_n$ can be written as $$\bar A_n = \frac{S}{n} \mu +  \frac{U}{\sqrt{n}},
\label{eq:An}$$ where $S \sim \mathcal{B}(n,\varepsilon)$, $U\sim \mathcal{N}_d(0_d,I_d)$, and $S$ and $U$ are independent. Moreover, conditionally to $S$, $\| \sqrt{n} \bar A_n\|^2$ has a noncentral chi-squared distribution with $d$ degrees of freedom and noncentrality parameter $\lambda_S= \| \frac{S}{\sqrt{n}} \mu \|^2$. Introduce $$h(S) = d + \lambda_S+ 2 \sqrt{ (d+ 2 \lambda_S ) x_\beta } + 2 x_\beta$$ with $x_\beta=\ln(4/\beta)$. According to Lemma \[LemmaLaurent\], $$\P_f \left( \| \sqrt{n} \bar A_n\|^2 > h(S) \ | \ S \right) \leq \frac{\beta}{4}.$$

Then, $$\begin{aligned}
\P_f( \Omega_{v_n}^c)
& = &  \P_f\left( \varepsilon \left\langle \mu,\bar A_n \right\rangle \leq \frac{C_{\alpha,\beta,M}}{n}\| \sqrt{n} \bar A_n\| \kappa_n \right),\nonumber \\
& \leq & \P_f \left( \varepsilon \left\langle \mu,\bar A_n \right\rangle


\frac{\beta}{8} +\frac{\beta}{4}.\\\end{aligned}$$ Note that, if $|S - n\varepsilon | \leq C_{1,\beta} \sqrt{n\varepsilon}$ and $\sqrt{n\varepsilon} > 2C_{1,\beta}$ then $S\in{\left[{\frac 1 2 n \varepsilon, \frac 3 2 n \varepsilon}\right]}$. Hence, on the event $|S - n\varepsilon | \leq C_{1,\beta} \sqrt{n\varepsilon}$ $$\begin{aligned}
\sqrt{h(S)}
&=& {\left({d + \lambda_S+ 2 \sqrt{ (d+ 2 \lambda_S ) x_\beta } + 2 x_\beta}\right)}^{\frac 1 2}\\
&\leq& \sqrt{d + 2 x_\beta + 2 \sqrt{d x_\beta}}  + \frac{S \|\mu\|}{\sqrt{n}}  + \sqrt{\frac{2\sqrt{2 x_{\beta}} S \|\mu\|}{\sqrt{n}} }\\
&\leq& a_{1,\beta} \sqrt{d} + \frac 3 2 \sqrt{n} \varepsilon \|\mu\|  +  \sqrt{3 \sqrt{2 n x_{\beta}} \varepsilon \|\mu\|  } \\
&\leq& a_{1,\beta} \sqrt{d} + a_{2,\beta} \sqrt{n} \varepsilon \|\mu\| \\\end{aligned}$$ since $S\leq \frac 3 2 n \varepsilon$ and $\sqrt{n}\varepsilon \|\mu\| \geq 1$, where $ a_{1,\beta}$ and $a_{2,\beta}$ are two positive constants. Then, asinequality $\frac{nx}{(nx-k)^2} \leq \beta$ is fulfilled if and only if $x\notin\left[\frac k n + \frac{2}{\beta n} \pm \frac{2\sqrt{1 + 4k\beta}}{\beta n}\right]$. Then, $$\P_f\left(Z_{(n-k+1)} < t_{\alpha_n,k}\right) \leq \beta,$$ if $$(1-\varepsilon) \bar\Phi\left(t_{\alpha_n,k}\right) + \varepsilon \bar\Phi\left(t_{\alpha_n,k} - \tau\right)
> \frac k n + \frac{2}{n\beta} +  \frac{2\sqrt{1 + 4k\beta}}{n\beta} .
\label{Cond1:unid}$$ Now, we consider $k \in \K_n$ such that $$\frac{0.99}{2} \bar\Phi(M)\leq \frac{k}{n} \leq  0.99 \ \bar\Phi(M) .$$ The set of solutions of this inequation is not empty since under the assumptions of Lemma \[lem:testunid\], $  0.99 \ \bar\Phi(M) n \geq 1$. Note that $|\K_n| \leq \log_2(n/2)$, hence $\alpha _n \geq \alpha/|\K_n| \geq
\alpha/\log_2(n/2)$. We will show that Condition is fulfilled. Using a Taylor expansion at the order 1, $$(1-\varepsilon) \bar\Phi\left(t_{\alpha_n,k}\right) + \varepsilon \bar\Phi\left(t_{\alpha_n,k} - \tau\right)
= \bar\Phi\left(t_{\alpha_n,k}\right) + \varepsilon \tau \phi(a)$$ where $a$


if used as directed, the Food and Drug Administration (FDA) requested further observational evidence of device efficacy and safety, and the study reported here was undertaken. This paper describes a confirmatory study required by the FDA to further assess the impact of device use over 16 weeks in adults with overweight and obesity in the USA. The device received FDA clearance in September 2016 [18](#osp4139-bib-0018){ref-type="ref"}.

Materials and methods {#osp4139-sec-0006}
=====================

Study design {#osp4139-sec-0007}
------------

This 16‐week, prospective, single‐arm, four‐centre, observational study assessed the impact of the device as a tool used in combination with a lifestyle programme delivered by video among a population aged 18--49 years with overweight and less severe obesity (class 1). The objective was to enrol an additional 70 or more participants (as recommended by the FDA) to confirm the efficacy andto be at least 33% of self‐reported eating episodes. The final PP criterion was completion of the study through week 16. Efficacy assessments of the co‐primary and secondary endpoints were analysed in the PP population. Safety analyses were based on the ITT population.

Study data are summarized with descriptive statistics. Means, standard deviations and 95% confidence intervals are reported for continuous variables. Counts, proportions and 95% confidence intervals for proportions are reported for categorical variables.

Results {#osp4139-sec-0014}
=======

Baseline characteristics, adherence and retention {#osp4139-sec-0015}
-------------------------------------------------

The baseline characteristics of the 76 subjects who were enrolled (comprising the ITT population) and 40 subjects who met PP criteria are presented in Table [1](#osp4139-tbl-0001){ref-type="table-wrap"}. Sixty‐seven subjects completed the last study visit (88%). Seven subjects withdrew consent, one was lost to follow‐up and one became pregnant. Subject disposition from


or even \<30 kg m^−2^ for patients to achieve clinically significant health benefits and to improve health risk [20](#osp4139-bib-0020){ref-type="ref"}.

Analysis of subjects in the Diabetes Prevention Program showed a 16% reduction in risk for progression to diabetes with every kilogram of weight loss [21](#osp4139-bib-0021){ref-type="ref"}. Another study found that achieving 3% TBL produced a 37% reduction in progression to type 2 diabetes over 4 years [22](#osp4139-bib-0022){ref-type="ref"}. More recently, investigators from the Look AHEAD study showed that improvement in triglycerides and systolic blood pressure begins with 2% to 5% TBL [23](#osp4139-bib-0023){ref-type="ref"}.

It is difficult to achieve weight loss in routine medical practice. Brief interventions produce on average 2% weight loss [24](#osp4139-bib-0024){ref-type="ref"}. Still, it is possible to achieve more weight loss with more intensive approaches. Comprehensive lifestyle intervention delivered face‐to‐face in at least 14 group orenvironment, meaning the air or atmosphere conveyed by the space around us. When people ride in an elevator, they sense things like air, light, and sound through their eyes, ears, and skin without being aware of doing so. They exhibit behaviors such as establishing a distance between themselves and the other people in the elevator, looking upwards, leaning against the walls, or in some cases holding the door to allow other people to exit. That is, people take in various sense impressions from elevators that unconsciously prompt them to engage in certain behaviors. I wanted to remove as many irritations as I could from this environment by keeping it in harmony with these behaviors.

The result was to create designs that were free of sharp edges. Just as people's


1. Field of the Invention
The present invention relates generally to an apparatus and method for reducing power consumption in a portable terminal. More particularly, the present invention relates to an apparatus and method for solving the problem of power consumption caused by the use of two RF modules in a multi-mode portable terminal supporting two Subscriber Identity Module (SIM) cards.
2. Description of the Related Art
The development of communication technology provides network systems of various communication schemes, and supports various network systems or only one network system according to the region. Also, the network system establishes different fee systems according to service providers. For example, in Russia, there is a great fee difference in network types according to the region. Thus, a conventional scheme equips a portable terminal withand strengthening our
internal unity around important national themes vital to our survival in a
modern era of globalization. These themes include:

1) the finality of our national identity; we are all Lebanese and proud,
2) the equality of our citizens and their rights regardless of ethnicity, faith
or creed,
3) the reform of our governmental institutions,
4) the open access to and the transparency of our government,
5) our freedoms of expression, speech, worship and creed,
6) our privacy and freedom from governmental intrusion,
7) the vitalization of our economy, creation of new jobs and retention of
brainpower,
8) the modernization of our education, health care and retirement systems,
9) the outreach to and involvement of the Lebanese Diaspora in our rebuilding
plans, and
10) the democracy of our decision-making process.

You are all invited to be part of this dialogue and to


the crossover effects and transition from Pauli to Coulomb crystals. It requires, however, a detailed knowledge of the N-body wavefunction of interacting system and is beyond the scope of this paper.

A single-shot measurement via fluorescence microscope can determine the spatial configuration of *N* atoms. Detection of Pauli crystals from single-shot measurement's outcomes may, however, be challenging. In a single-shot the positions of *N*-atoms can be obtained but the outcome of such detection is unpredictable because of probabilistic nature of quantum mechanics. It is different in every realization. Therefore it is very difficult to notice any geometric arrangement of atoms. But the most frequent ones might be quite similar^[@CR27]^. In fact *N*-body probability density has a maximum for a certain arrangement of fermionic atoms -- Pauli crystals. One can \usepackage{upgreek}
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                \begin{document}$$\varepsilon $$\end{document}$ from the selected point. In Fig. [2](#Fig2){ref-type="fig"}, we set $\documentclass[12pt]{minimal}
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