is also "A Dirty Dozen: Twelve P-Value Misconceptions" (Goodman 2008) http://www.ncbi.nlm.nih.gov/pubmed/18582619 which claims something similar.
Can anyone clarify my confusion?
Thank you!
Vincent

A:

A paper that may help is

Murdock, D, Tsai, Y, and Adcock, J (2008) P-Values are Random
  Variables. The American Statistician. (62) 242-245.

Imagine that you have a coin that you want to test if it is fair (maybe it is bent or otherwise distorted) and plan to flip the coin 10 times as your test.  Clearly if you see 5 heads and 5 tails then you can't reject the null that it is fair and most people would be highly suspicious of the coin if you saw 10 heads (or 10 tails), but to be fair we should set up before the test a rule or rejection regionto determine if we should reject the null hypothesis (fair coin) or not.
One approach to deciding on the rejection region is to set a limit on the type I error rate and choose the rejection region such that the most extreem values whose cumulative probabilities are less than the limit will constitute the rejection region.  So if we use the traditional 0.05 as our cut-off then we can start with the extreems and see that if the coin is fair (null is true) then the probability of seeing 0, 1, 9, or 10 heads is less than 5%, but if we add in 2 or 8 heads then the combined probability goes above 5%, so we will reject the null if we see 0, 1, 9, or


in the area (as opposed to free moving)

Your time and feedback is appreciated as always..

Kev

PS. I've fixed the frame rate to 30 so hopefully its not going to tie peoples systems up.

The jerky movement in the demo makes conclusions a little tricky - suggest you smooth it a bit to be sure that people are providing apt feedback. If you aren't seeing jerkiness yoursefl, erm...well this is on my normal 1Ghz machine nothing else really running so I don't know why it's jerky . But I'm assuming it's because you've got a quick hack positional interpolation that's coarse grained at the moment...?

For point-n-click games of this style, frequent clicking is tiring, slow and ultimately leads to RSI. A vast number of people end up just holding the mouseminus networking last year. The thing that stopped me cold was object management/interactions. Thats when I started exploring scripting and never really got back to the game.

I'm curious about your command/order protocol. The system I've played with in scripting is variable length arg events (Obj [] in java) to objects (and the game engine) via a GameObject.doEvent(Object []). I was thinking something similar to this would work well over a network; event type would be first element of the array.

I'm curious if I'm on the right track here?

Otherwise, the controls responded as I expected; to my knowledge the Baldurs Gate games didn't do the follow-the-mouse-drag movement, they were click and move like yours.

I've actually just swapped to keys (which keeping a backup of the old stuff ). Somehow


organs’ ubiquity (50% of all deer pop.), it has always fetched a rather high price in Chinese markets.

As with all matter relating to sexual/reproductive organs, most people tend not talk openly about the consumption of this cut of meat in polite conversation. But those well acquainted with Chinese culinary culture will know of the existence of deer penis dishes. Many who have visited well stocked Chinese dried good stores would have no doubt seen desiccated specimens of this organ showcased in the glass display cases or jars. Some would no doubt have already tried it.

Which makes it somewhat surprising that at this day and age, Chinese recipes for deer penis is not more widely available in the English language, especially considering recent fashions in nose-to-tail eating. Fuschia Dunlop’scurious and graphic recounting of her experience preparing this particular cut of meat is of course, a must-read. Her description of its texture while cooking and slicing it is as vivid as it is hilarious. The dish she prepared however, isn’t really the typical way of preparing deer penis. Strongly seasoned and spiced, her red-cooked stew goes well beyond what is the norm for preparing traditional restoratives. And much to my dismay too, she did not publish the recipe.

For this, I’ve translate the following 1970s Hong Kong deer penis recipe. The recipe itself is rather typical for meat containing restoratives, with flavours and light seasoning more in line with what one would expect when being served such a dish. Strangely, the recipe here skips instructions in how to


that the IAU has a corner on the market on what a definition is. We in the planetary science field don’t need the IAU definition. The definition of words is based partly on how they are used. If [the geophysical definition] is the definition that people use and what teachers teach, it will become the de facto definition, regardless of how the IAU votes in Prague.”

Regardless of where people fall on the IAU’s definition of planet (or the one proposed by Runyon and his colleagues) it is clear that the debate is far from over. Prior to 2006, there was no working definition of the term planet; and new astronomical bodies are being discovered all the time that put our notions of what constitutes a planet to thetheory of dispersed composites. The main results are obtained for 2D problems which will be considered in details.

Let $\omega_1$ and $\omega_2$ be the fundamental pair of periods on the complex plane $\mathbb C$ such that $\omega_1>0$ and $\textrm{Im}\; \omega_2 > 0$ where $\textrm{Im}$ stands for the imaginary part. The fundamental parallelogram $Q$ is defined by the vertices $\pm \frac{\omega_1}2$ and $\pm \frac{\omega_2}2$. Without loss of generality the area of $Q$ can be normalized to one. The points $m_1 \omega_1+ m_2\omega_2$ ($m_1,m_2 \in \mathbb Z$) generate a doubly periodic lattice $\mathcal Q$ where $\mathbb Z$ stands for the set of integer numbers. Introduce the zero-th cell $$Q= Q_{(0,0)}=\left\{z=t_1 \omega_1+i t_2 \omega_2 \in  \mathbb{C}:-\frac{1}2<t_1,t_2<\frac{1}2\right\}.$$ The lattice $\mathcal{Q}$ consists of the cells $Q_{(m_1,m_2)}=Q_{(0,0)}+m_1\omega_1+i m_2\omega_2$.

Consider $N$ non–overlapping simply connected domains $D_k$


of [@Natanzon] is based on the periodization of the complex potential $\varphi(z)$ without summation over the cells (we take the derivative as in [@Natanzon]) $$\varphi'(z)  = A_0+A_2 \wp(z)+ A_4 \wp''(z)+ A_6 \wp^{(iv)}(z)+\ldots.
 \label{eq:Ray2b1}$$ Filshtinsky used the series $$\varphi(z)  = A_0 z -A_2 \zeta(z)- A_4 \zeta'(z)- A_6 \zeta'''(z)-\ldots,
 \label{eq:Ray2b}$$ where $\zeta(z)$ and $\wp(z)=-\zeta'(z)$ are the Weierstrass elliptic functions. Application of series - allows to avoid the study of the conditionally convergent lattice sum $S_2$.

The Kolosov-Muskhelishvili formulae express the stresses and deformations in terms of two analytic functions. One of the functions has to be doubly periodic, hence, can be presented in the form . However, a combination of the first and second analytic functions satisfies periodic conditions which yields the following representation for the second function $$\Phi(z)top-down signals (language and action) should also be additive. Thus we expected the best performance on trials when cue, prime, and target were all congruent.

General Method {#s2}
==============

All experiments were approved by the University of Plymouth\'s Human Ethics Committee, and informed consent was obtained from all participants.

Language cues and action primes
-------------------------------

Using a flicker paradigm, the experiments reported below attempted to enhance change detection by weighting size-related features of the target in a top-down manner. This weighting was achieved using language cues and action primes. The language cues actually specified overt searching behaviors. *Partially valid* cues (Experiments 1, 3, and 4), which were valid for half of the time, instructed participants how to *start* their search (e.g., "Start looking for a change in the larger objects"). Participants were told that


if they could not find the target easily, they should include non-cued objects in their search (i.e., they only had to *start* their search based on the cue). *Completely valid* cues however (Experiment 2), were always valid, and instructed participants how to conduct their search throughout (e.g., "Look for a change in the larger objects"). The association between the language cue and the object\'s size was therefore explicit, whereas for the action prime it was implicit. Furthermore, the action primes did not specify any overt searching behavior. Partially valid (Experiments 2 and 4) or completely valid primes (Experiment 3), simply instructed participants which response device to hold (thereby establishing an action intention for a particular grasp). It is assumed that relative to one another, partially and completely valid Partially valid
  Action Primes of target size (power/precision grasp intention)   Partially valid                        --                Partially valid    Completely valid   Partially valid

*In each experiment either a Language Cue and/or an Action Prime preceded the onset of a change-detection scene in which participants searched for an unknown changing target. See preceding text for descriptions of types of cues and primes used*.

Change detection paradigm
-------------------------

Some of the following methodological details have been adapted from Symes et al. ([@B45]). Change-blindness scenes consisted of an array of 12 grayscale


in by 10.5 cm from the table\'s leading edge. When holding this apparatus, the hand-to-screen distance was approximately 30 cm. The apparatus was fixed to the table top in a vertical position and consisted of two physically connected devices -- a cylindrical "power device" (*l* = 10 cm; diameter = 3 cm), and a square "precision device" (*l* = 1.25 cm, *w* = 1.25 cm, *h* = 1.25 cm). A power grasp was required to hold the power device and a precision grasp was required to hold the precision device. In order to avoid establishing any semantic associations between the devices and their size or required grasp (i.e., ensuring the association between the action prime and the object\'s size was implicit), the power device was neutrally referred to by the experimenter (and the on-screen instructions) as the "Black device" (it was colored black) andvariation of two within-subjects variables, each with two levels were: Language Cue (large or small) and Action-primed Target Size (large or small).

Results and discussion
----------------------

3.29% of trials were removed as errors (0.44% response errors, 2.90% change identification errors, 0.04% both errors on same trial). No further analysis of errors was undertaken. 5.50% of the remaining trials were removed as outliers, reducing the maximum detection time from 27,686 to 13,200 ms (*M* = 4,087 ms; SD = 2,213).

### The effect of action primes

Mean cropped experimental RTs for each participant were compared for the current experiment and Experiment 1, in order to establish whether completely valid action primes enhanced overall detection times (see prediction 3a above). The only methodological difference between the two experiments was the presence of an action prime in the current experiment (this, along


by valid language cues whilst nevertheless benefiting from concurrently valid action primes (see "Small and Large targets" columns of Table [2](#T2){ref-type="table"}).

The ANOVA output revealed a three-way interaction between Language Cue, Action Prime and Target Size that was statistically significant at the 10% level, *F*(1, 19) = 3.840, *p* = 0.065. In examining this interaction, the biasing effect of action primes appeared stronger under one level of Language Cue -- namely "large" cues. Thus with *large language cues* the effect size was 200 ms, with mean detection times that were faster for large targets following a large (3,088 ms) rather than small (3,388 ms) action prime, and faster for small targets following a small (4,954 ms) rather than large (5,055 ms) prime. However, with *small language cues* the effect size was only 33 ms, with mean detection times thatrounded to six dps?
0.000012
Let o = 10.5 - 12. Let g = 1 + o. Let z = 0.5008 + g. Round z to 4 decimal places.
0.0008
Let w = -6874 - -7518.6. Round w to the nearest ten.
640
Let l = -42.07 + 42.04727. What is l rounded to 3 decimal places?
-0.023
Let y = -65778.42771 + 65777. Let z = y - -1.43. Round z to four decimal places.
0.0023
Suppose 272310 + 14990 = 17*h. Round h to the nearest one thousand.
17000
Let x = -206.9 + 172.45. Round x to the nearest integer.
-34
Let z = 194.9999466 - 195. Round z to 6 decimal places.
-0.000053
Let o be (-44)/198 + (-40)/(-18). Let n(a) = 1773*a**2 + 3*a + 2. Let z be n(o). What is z rounded to the nearest one thousand?
7000
Let


person influences how you feel toward that person. When you act in love, you feel in love.

To be clear, I’m not saying couples should pair up at random and pretend to love each other. What I’m suggesting is that once you connect with a person who you enjoy and respect, be willing to be vulnerable and to tune out that doubting voice that stands in your way of happiness. This brings me to the second step in creating a perfect imperfect relationship: stop listening to your inner critic. The “critical inner voice” is a term my father has used to describe that coach in people’s heads that stands at the helm of self-sabotaging behaviors. This voice will tell you that you are unworthy of a nice relationship. Itdifferences in dust properties seen beween the MW and SMC, where the dust-to-gas ratio departs from a linear scaling with metallicity [@remyruyer2014; @RD2014; @RD2017], the PAH fraction is an order of magnitude lower than in the MW [@sandstrom2010], and the UV extinction curves distinctively lack a 2175 [Å]{}bump and are steeper in the FUV than in the MW [@gordon2003]. In addition, the LMC’s gas disk is thinner [120 pc @elmegreen2001] and less inclined than the SMC, alleviating confusion in velocity and distance structure along the line-of-sight. Finally, we have considerable ancillary data to trace the LMCÕs stellar and ISM content from Spitzer, Herschel, FUSE, IUE, and ground-based facilities [@meixner2013 and references therein].\
There have been several investigations of dust evolution in the LMC by measuring its dust and gas


content with Spitzer, Herschel [@meixner2006; @meixner2013], IRAS, and Planck [@RD2017], in addition to ground-based measurements of CO [@wong2011], [[H]{}[[i ]{}]{}]{}[@kim2003], and H$\alpha$ [@gaustad2001]. These emission-based measurements suggest that the dust abundance and size increase from the diffuse to the dense ISM [@RD2014; @RD2017]. Because the FIR surface brightness from dust emission is the product of the dust opacity and surface density, however, those quantities are degenerate. The FIR opacity of dust is known to vary with metallicity, density, and temperature [@stepnik2003; @kohler2012; @demyk2017], but the dependence of the opacity on such physical parameters is not well constrained. As a result, the observed variations of the dust abundance measured from FIR emission could stem from variations of the opacity. Additionally, unaccounted for CO-dark gas and variations of the CO-to-H$_2$and photometry, it is expected that this large sample of observations in the LMC will also be used for other purposes, such as characterizing the wind properties of massive stars at half-solar metallicity, and studying the nature and origin of galactic-scale outflows in the LMC.\
The paper is organized as follows. In Section \[design\_section\], we provide an overview of the design of the program. In Section \[reduction\_section\], we describe the METAL data reduction. Section \[photometry\_section\] describes the point source extraction and photometry for the parallel WFC3 imaging data. In Section \[results\_section\], we present initial results from the METAL data analysis that highlight the overarching science goals of the program. Section \[conclusion\_section\] summarizes this work.

Survey Design {#design_section}
=============

Achieving our goal of measuring dust properties in the LMC required careful selection of


corresponding to 7 km s$^{-1}$) in the FUV, in combination with STIS/E230M/1978 (at R $\simeq$ 30,000 corresponding to 10 km s$^{-1}$) in the NUV. STIS/E230M is the most efficient way to cover the NUV at medium resolution because it covers all NUV lines with one setting (the striping of COS/NUV would require multiple settings and more time than STIS).\
In the FUV, targets were preferentially observed with STIS/E140M to maximize spectral resolution, which is critical in ISM studies due to the low velocity dispersions. For most targets, the difference in orbits between COS/FUV+STIS/NUV and STIS/FUV+NUV was less than an orbit due to the overhead in changing instruments, and in those instances STIS/E140M was used. All observations using STIS E140M and E230M used the 0.2”x0.2” aperture. The targets that couldthe minimum equivalent width (EW) we expected for this line was 10 mÅ. This can be achieved (at 4$\sigma$) with S/N=25 per resolution element with COS/1291, and S/N=15 per resolution element with STIS/E140M. For COS/G160M, we targeted S/N = 15 per resolution element to probe the strong Fe II and Si II lines. In the NUV, we targeted S/N = 15 per resolution element with the E230M on the Si II (1808 Å) and Fe II (2249 [Å]{}— 2260 Å) lines. This S/N was also sufficient to derive Cr, Zn column densities. For the COS observations, we used spectral dithering with 4 FPPOS to minimize fixed pattern noise. COS observations were taken in TIME-TAG mode, while STIS observations were taken in ACCUM mode.\
Straightforward COS ACQ/IMAGE target acquisitions were


STIS allowed for WFC3 exposures with the full suite of filters (F225W, F275W, F336W, F475W, F814W, F110W, and F160W). The more orbits, the more exposures were taken to optimize cosmic ray rejection and exposure time. The list of WFC3 exposures, the orientation of each field (PA), the coordinates of the field centers, the exposure times, and durations of the post-flash implemented to reduce CTE (charge transfer efficiency) effects, are listed in the Appendix (Table A4).\

Data Reduction {#reduction_section}
==============

In the following section, we describe in detail the data reduction for the different components (medium-resolution COS and STIS spectroscopy, WFC3 imaging) of the METAL observations (doi:10.17909/T90Q30).

![image](fig6a){width="8cm"} ![image](fig6b){width="8cm"}

![image](fig6c){width="8cm"} ![image](fig6d){width="8cm"}

STIS spectroscopy
-----------------

The STIS observations, listed in Tables 3, 4, and 5, were taken between September 2016 and July 2017, and retrieved from the [*Mikulskia star with known properties to the original images, and then re-running the photometry on the synthetic images to determine if the star is recovered, and how close the measured magnitude is to the true magnitude. We chose the input photometric properties using the Bayesian Extinction and Stellar Tool [BEAST, @gordon2016] to sample the stellar model space to which our data were sensitive. By running many thousands of such tests, we can accurately model the photometric bias and error in the model space used by the BEAST for fitting the multi-band spectral energy distributions of the resolved stars. Figure \[plot\_asts\] shows examples of the bias and standard deviation in the recovered photometry compared to the input photometry for the field taken in parallel to the SK-68140 spectroscopy, and


velocities, the boundary for gas associated with the LMC is poorly defined, owing to the presence of additional features that are at velocities between those associated local Milky Way and those arising clearly from within the LMC (see Section \[ivg\_section\]). Observations of [[H]{}[[i ]{}]{}]{}21 cm emission in the GASS III survey [@mccluregriffiths2009; @kalberla2010; @kalberla2015] in the directions of our target stars reveal a well defined feature arising from gas in the LMC, and only rarely is there any evidence for components at intermediate velocities (and when they do appear, they have very low amplitudes). For this reason, we define the lower limit for velocity at the edge of the [[H]{}[[i ]{}]{}]{}21 cm emission, where the brightness temperature rises above 0.2 K ($\sim$4$\sigma$). This usually corresponds to a heliocentricthan in the MW.\
The fraction of silicon in the dust (or gas) phase in the LMC and SMC appears to scale with inverse metallicity. As a result, the gas-phase abundances of silicon in the MW, LMC, and SMC are similar and follow similar trends with total hydrogen column density (Figure \[plot\_si\_dep\]). The bottom panel of Figure \[plot\_si\_dep\] also shows that the silicon gas-phase abundances in a large sample of DLAs and sub-DLAs from @quiret2016 follow very similar trends. These trends will be examined for other elements in Paper II. If other elements follow the same trend (which will be determined in Paper II), then the dust-to-metal ratio (D/M) in the SMC would be four times lower than in the MW, and D/M would be 1.5 times lower in


BM was supplemented with 7.7 μM hemin (Fluka) (Hm), 7.7 μM protoporphyrin IX (PPIX) or 5% inactivated fetal bovine serum (Sigma) (FBS). To analyze the influence of chosen divalent ions on *P. gingivalis* growth and gene expression, BM was supplemented with 100 μM ZnCl~2~ (Zn^2+^), 100 μM FeSO~4~ (Fe^2+^), or 100 μM MnCl~2~ (Mn^2+^). To starve bacteria from iron and heme, cells were grown in the absence of heme and in the presence of an iron chelator, 160 μM 2,2-dipyridyl (DIP) (Sigma). *P. gingivalis* mutant strains were maintained in the presence of 1 μg/ml erythromycin. Complemented and control strains were maintained in the presence of 1 μg/ml erythromycin and 1 μg/ml tetracycline. Bacterial growth in liquid media was determined by measuring optical density at 600 nm (OD~600~) andThis study
  *Pgfur* + HA                      A7436 strain producing PgFur protein with HA tag (YPYDVPDYA) at the C-terminus                            This study
  Δ*pgfur* + *pgfur*                Δ*pgfur* strain complemented with pTIO-tetQ + *pgfur* encoding wild-type PgFur protein                    Smiga et al., [@B72]
  Δ*pgfur* + C102A


bind regulatory metal, namely CPL, such a motif is present only in *P. gingivalis* and *P. gulae*, but in the closely related *P. loveana* Fur homolog cysteine is substituted by serine ([Figure 3](#F3){ref-type="fig"}), suggesting that it is very unlikely that the cysteine from the CPL motif could be involved in regulatory metal binding.

To further examine the importance of potential metals for PgFur function, we compared *pgfur* gene expression in *P. gingivalis* grown under several conditions of ligand availability with that occurring in bacteria partly starved in BM, the latter mimicking those occurring in oral cavity of healthy individuals (low iron levels and lack of heme). As shown in [Figure 6A](#F6){ref-type="fig"}, the *pgfur* gene was expressed at the highest levels when bacteria were cultured for 24 h in thepresented in this report confirm a different mechanism of PgFur function compared to canonical Fur proteins ascribed to the Fur superfamily members and support existence of a novel Fur subfamily, evolved in some *Porphyromonas* species, comprising keystone periodontopathogens of chronic periodontitis.

Data Availability {#s5}
=================

The data for this study can be found in the GenBank database under accession number MK599280.

Author Contributions {#s6}
====================

TO, MŚ, and MO designed the study. MŚ, MO, and MB performed the experiments. TO wrote the manuscript and provided financial support. All authors performed data analysis and approved the final version of the manuscript.

Conflict of Interest Statement
------------------------------

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

We thank Richard Ashcroft for correcting


rented for $32.50 per month. The court held that her use of one of the apartments was worth as much or more than her claim for $2.50 per month, and, therefore, her demands for the excess were refused. We find this ruling free from error.
In charging error to the court's ruling that Jewel Lean Davis should be recognized as owner of an undivided one-half interest in the real estate, counsel for the heirs of Jerry W. Davis rely on the authority of Jackson et al. v. Hampton, La.App., 134 So.2d 114 (2d Cir. 1961). In the instant case the real estate in question consists of Lots 17 and 18 of Block "H" of the Mandel Addition of Caddo Parish, Louisiana, with improvements thereon and was purchased *483 inJewel Lean Davis were contracted within a period of seven years, and all of them were performed in the immediate vicinity of Shreveport. The ultimate finding of the trial court was that Jewel Lean Davis was not truthful in her protestation of good faith, the court believing that she was not as ignorant as she pretended. With this ruling we find ourselves in complete accord. We find it difficult to believe that appellant was other than a rather intelligent young colored woman, as pictured by the trial court. It is, therefore, our finding that Jewel Lean Davis was not in good faith at the time of her marriage to Jerry W. Davis, and, therefore, she cannot claim the civil effects which inure to the benefit of a putative


wife.
A further contention made by Jewel Lean Davis is that if she be not found to be a legal or a putative wife, then she must be considered as a partner. The record entirely refutes any such partnership status. A partnership constitutes a contract and must be created by the consent of the parties. LSA-C.C. Arts. 2801 and 2805. The appellant testified that she did not have such requisite agreement with the deceased. The demands, therefore, that appellant be considered as a partner in the several ventures of Jerry W. Davis and in his estate, must be rejected.
Accordingly, it is our finding that the judgment from which appealed should be affirmed. IT IS THEREFORE ORDERED, ADJUDGED AND DECREED that there be judgment herein in favor of the saidto flow out of the battery to perform work. Historically the term “battery” specifically referred to a device composed of multiple cells, however the usage has evolved additionally to include devices composed of a single cell.

Primary (single-use or “disposable”) batteries are used once and discarded; the electrode materials are irreversibly changed during discharge. Common examples are the alkaline battery used for flashlights and a multitude of portable electronic devices. Secondary (rechargeable) batteries can be discharged and recharged multiple times using an applied electric current; the original composition of the electrodes can be restored by reverse current. Examples include the lead-acid batteries used in vehicles and lithium-ion batteries used for portable electronics such as laptops and smartphones.

The high-capacity Canon BP-511A Rechargeable Lithium-Ion Battery features lithium technology, which ensures maximum


 "description": "a foo topology",
    "nodes": [
        {
            "cachegroup": "child-cachegroup",
            "parents": [1, 2]
        },
        {
            "cachegroup": "parent-cachegroup",
            "parents": []
        },
        {
            "cachegroup": "secondary-parent-cachegroup",
            "parents":Topology
- a Topology cannot have `STEERING` or `CLIENT_STEERING` delivery services assigned to it (because those types are not assigned to caches -- their _targets_ are)

The following new endpoints will be required:

##### `GET /topologies`

response JSON:
```JSON
{ "response": [
    {
        "name": "foo",
        "description": "a foo topology",
        "nodes": [
            {
                "cachegroup": "child-cachegroup",
                "parents": [1, 2]
            },


Cachegroup that is currently used in a Topology.

`PUT /cachegroups` should update all foreign key references if `name` is updated. This should be done automatically in the database via the FK references.

##### The various `/snapshot` endpoints

The various `/snapshot` endpoints will need to be updated to include new Topologies data along with their associations to Delivery Services in the `CRConfig.json` snapshot. The data should only include the `EDGE_LOC` cachegroups of the Topologies, because those are all Traffic Router needs. Additionally, delivery service required capabilities and server capabilities data will need to be added in order for Traffic Router to take them into account. This is because delivery services that are assigned to Topologies will not be explicitly assigned to individual servers. Servers are transitively assigned to topology-based delivery services basedthat delivery service are determined via the Topology it's assigned to. Otherwise, the parents are determined by the server's cachegroup as they are today.

Since new Topologies can be more than 2 tiers (`EDGE` -> `MID`), `atstccfg` may need to break some assumptions about the current 2-tier hierarchy in order to work with an arbitrary number of "forward proxy tiers" -- e.g. `EDGE` -> `MID` -> `MID` -> `ORIGIN`. Basically, `MID` caches need to be able to forward requests to other `MID` caches -- they can no longer assume that their parents are always origins.

#### ATS config-related fields on Delivery Services

*Topology-based* delivery services will use the new `firstHeaderRewrite`, `middleHeaderRewrite`, and `lastHeaderRewrite` fields (described in the REST API Impact section above) for adding ATS header_rewrite configs. If a cache is


two different ways to assign Delivery Services, but this overhead should be temporary as CDN operators should migrate all Delivery Services to Topologies as soon as possible. That one-time manual migration should also be considered an operational impact and should be scheduled to take place sometime after the upgrade is completed.

Once all Delivery Services have been migrated to Topologies, CDN operators will no longer have to "clone Delivery Service assignments" from a nearby edge cache in the same cachegroup when adding a new edge cache into the CDN. Since Topologies are composed of cachegroups, simply adding a server into a particular cachegroup will give it all the Delivery Service assignments from all the Topologies the cachegroup is used in.

Troubleshooting issues with Delivery Services on the CDN may become2019, David helped organise, and  alongside Michael Palin, Twiggy and others, appeared in the ‘Just A Book’ poster campaign on the London Underground. The campaign was created to support independent businesses and bookshops on British highstreets and also to raise funds for Anno’s Africa.

The Woodland Trust and Environmental Activism
Since 2019, David has been an Ambassador for the Woodland Trust. On October the 9th, 2019, David hosted a discussion at the 70th Cheltenham Literature Festival on the subject of "The Art of Trees". In the press release for the event, David said:

Writing in an editorial for the Sunday Times on the 2nd of November, 2019, David said:

On Thursday the 30th of January 2020, David was a co-signatory, with the CEOs of The Wildlife Trusts, the National Trust, the


The role of Dutch general practitioners in clinical health promotion.
In this contribution it is argued that Dutch general practitioners (GPs) must make the transition from simply giving information to their patients, to providing them with medical education. Dutch GPs are in a prime position to contribute to the aims of health promotion. Instead of focusing health promotion on prevention, they should primarily promote the health of their patients, especially these patients with a chronic disease. In order to provide proper care for their disabled patients, they have to limit the time they spend on caring for people suffering from minor ailments. Again, this aim cannot be achieved by simply providing information. The patients have to overcome their reluctance to change their consultation behaviour, but the GPs also haveXXIV
Max only needed one round against Erix to realize that he wasn’t going to last long at this rate.

Erix just kept pressing him back, pushing him around to a degree even Striker had never managed. Before his opponent could strike again, Max drew his backup laser sword, the one he found in the Harken Building. He had meant to hold it back as a reserve weapon, but he now understood that if he didn’t change his tactics, he wouldn’t need a backup anyway.

“You didn’t tell me you had another sword.” Erix grinned.

All Max could come up with was, “You never asked. And what about yours?”

“Fair enough,” he conceded.

Max tried to use one blade to block, the other to counter. In his mind, he heard Robert quip, Having two


Lance Armstrong ADMITS to doping on Oprah.

No Sport will ever be 100% clean. There will always be cheaters who try to subvert the rules.

However, I can say with certainty that the culture of Juicing in MLB has changed drastically since the MLB cracked down.

Just look at the line-ups of teams from the late 90's-early2000's and see the difference in size of the upper bodies on these guys. I won't go
into a list of all the suspects but surely an astute observer notices.

Hell, average second basemen who rightly should only be hitting 15 homeruns (tops) were jacking 35 dingers a year, with biceps barely contained in
their jerseys.

Yeah, it changed drastically in that people don't have free reign to use anything they want anymore, now they have to pick andplace...

edit on 18-1-2013 by Xtrozero because: (no reason given)

He sued people when they claimed he took drugs. People lost a lot of money and respect because of him. So yes, he's at fault. He knowingly lied and
actively worked to destroy the reputations of the people who said he took drugs. That is public knowledge. If you don't think it's ate up to
actively work to wreck people's finances and lives while knowing the whole time they were telling the truth then I just don't know what to say to
you.

This content community relies on user-generated content from our member contributors. The opinions of our members are not those of site ownership who maintains strict editorial agnosticism and simply provides a collaborative venue for free expression.


containing 10% FBS (Biochrom/Merck, Berlin, Germany), 11 mM glucose (Thermo Fisher Scientific, Darmstadt, Germany), 2 mM glutamine, 100 U/mL penicillin, 100 µg/mL streptomycin, 1 mM pyruvate, 1% non-essential amino acids, 0.8 µg/mL hydrocortisone (Pfizer, Berlin, Germany), and 50 µU/mL insulin (Sigma-Aldrich) \[[@B22-nutrients-11-01795]\]. HepG2 cells were cultivated in RPMI-1640 media with 10% FBS, as published previously \[[@B23-nutrients-11-01795]\]. Since the presence of FBS could interfere with the proteomics measurements, fresh media without FBS was given to the cells, and 20 h later, the condition media (supernatant) was collected. The conditioned media were centrifuged for five minutes at 800 g at 4 °C to discard cell debris. The supernatants were frozen at −80 °C. Four independent samples were collected from PHH and HepG2 cells, respectively.

2.4. Liquid Chromatography Coupled to Tandem Masscomparison of PHH and HepG2 cells secretome shows a high overlap. Nevertheless, in detail, the secretome of HepG2 cells rather reflects the fetal liver with special cancer characteristics, which has to be considered, when HepG2 cells are used as a model for secretome studies.

We gratefully acknowledge Alke Guirguis for her technical assistance (Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital Tübingen, Tübingen, Germany).

The following data are available online at <https://www.mdpi.com/2072-6643/11/8/1795/s1>, Table S1: Proteomics data, Table S2: PHH riBAQ list, Table S3: HepG2 riBAQ list, Table S4: PHH and HepG2 specific proteins.

######

Click here for additional data file.

Conceptualization: J.K., S.L., H.U.H., and A.P.; methodology: A.F., S.H., M.R., and J.K.; software: A.F. and S.H.; resources: A.K.N. and A.K.; writing---original draft preparation: A.F. and S.L.; writing---review


using MaxQuant for at least three out of four replicates. (**A**) shows the top 50 proteins with the highest riBAQ values, average values of the replicates and protein names are shown in [Table 2](#nutrients-11-01795-t002){ref-type="table"}. (**B**) HepG2 riBAQ list---top 50 proteins. In HepG2 samples, 745 secreted proteins were identified and quantified, from which riBAQ could be calculated using MaxQuant for at least three out of four replicates. (**B**) shows the top 50 proteins with the highest riBAQ values, average values of the replicates and protein names are shown in [Table 3](#nutrients-11-01795-t003){ref-type="table"}. Heat maps show log~2~ data.](nutrients-11-01795-g002){#nutrients-11-01795-f002}

nutrients-11-01795-t001_Table 1

######

Pathway enrichment of PHH secretome.

  Term ID      Term Name                          \<0.0001
  GO:0006629   lipid metabolic process                            \<0.0001
  GO:0097006   regulation of plasma lipoprotein particle levels   \<0.0001
  GO:0034369   plasma lipoprotein particle remodeling             \<0.0001

The 691 secreted proteins identified in the primary human hepatocytes (PHH) secretome were subjected to pathway analysis using g: Profiler, selected pathways are shown. Term identification numbers (Term ID) represent biological process gene ontology (GO) terms. adj. *p*-value: Benjamini-Hochberg adjusted *p*-value.

nutrients-11-01795-t002_Table 2

######

PHH riBAQ list---top 50 proteins.

  Prot. ID


with other parts of the genome,” Dr Kouprina said.

“The idea is to take skin cells from a patient, turn them into stem cells and insert HACs into these stem cells with healthy copies of the disease gene. These cells, with the extra chromosome, can then be inserted back into the patient to treat the illness.”

She continued: “Clearly there is a long way to go before we can use HACs as vectors for treating genetic disease. However, the potential is there and this is an exciting area for scientific exploration with great potential benefits.”

Paul Freemont of Imperial College, one of the leaders of the synthetic yeast project, said that human artificial chromosomes produced by scientists such as Dr Kouprina are much smaller than natural human chromosomes and do notis divided by n.
17
What is the remainder when 165 is divided by (6 + -2 + -2)*(-24 + (-1089)/(-22))?
12
Let o(s) = s**3 - 19*s**2 - 8*s + 19. Let v be o(19). Let j = v + 149. Calculate the remainder when 55 is divided by j.
7
Calculate the remainder when 105 is divided by 43/258 + (-1)/((-18)/447).
5
Suppose 120 = -14*v - 26*v. Suppose -5*r = -2*b + 3, -4*r + 66 = 4*b + 18. What is the remainder when 1 + b/v + 49 is divided by 16?
15
Calculate the remainder when (-9 - -1)*7425/(-216) is divided by 101.
73
Let p(h) = -6*h**3 - 2*h - 2. Let j be p(-2). Suppose -11*l = -9*l - j. What is the remainder when 94 is divided by l?
19
Let m(b) =


sge->cmdQ[0].size,
			  A_SG_CMD0BASELWR, A_SG_CMD0BASEUPR, A_SG_CMD0SIZE);
	setup_ring_params(ap, sge->cmdQ[1].dma_addr, sge->cmdQ[1].size,
			  A_SG_CMD1BASELWR, A_SG_CMD1BASEUPR, A_SG_CMD1SIZE);
	setup_ring_params(ap, sge->freelQ[0].dma_addr,
			  sge->freelQ[0].size, A_SG_FL0BASELWR,
			  A_SG_FL0BASEUPR, A_SG_FL0SIZE);
	setup_ring_params(ap, sge->freelQ[1].dma_addr,
			  sge->freelQ[1].size, A_SG_FL1BASELWR,
			  A_SG_FL1BASEUPR, A_SG_FL1SIZE);

	/* The threshold comparison uses <. */
	writel(SGE_RX_SM_BUF_SIZE + 1, ap->regs + A_SG_FLTHRESHOLD);

	setup_ring_params(ap, sge->respQ.dma_addr, sge->respQ.size,
			  A_SG_RSPBASELWR, A_SG_RSPBASEUPR, A_SG_RSPSIZE);
	writel((u32)sge->respQ.size - 1, ap->regs + A_SG_RSPQUEUECREDIT);

	sge->sge_control = F_CMDQ0_ENABLE | F_CMDQ1_ENABLE | F_FL0_ENABLE |
		F_FL1_ENABLE | F_CPL_ENABLE | F_RESPONSE_QUEUE_ENABLE |
		V_CMDQ_PRIORITY(2) | F_DISABLE_CMDQ1_GTS | F_ISCSI_COALESCE |
		V_RX_PKT_OFFSET(sge->rx_pkt_pad);

#if defined(__BIG_ENDIAN_BITFIELD)
	sge->sge_control |= F_ENABLE_BIG_ENDIAN;
#endif

	/* Initialize no-resource timer */
	sge->intrtimer_nres = SGE_INTRTIMER_NRES * core_ticks_per_usec(ap);

	t1_sge_set_coalesce_params(sge, p);
}

/*
 * Return the payload capacity of the jumbo free-list buffers.
 */
static inline unsigned int jumbo_payload_capacity(const struct sge *sge)
{
	return sge->freelQ[sge->jumbo_fl].rx_buffer_size -
		sge->freelQ[sge->jumbo_fl].dma_offset -
		sizeof(struct cpl_rx_data);
}

/*
 * Frees all SGE related resources and the sge structure itself
 */
void t1_sge_destroy(struct sge *sge)
{
	int i;

	for_each_port(sge->adapter, i)
		free_percpu(sge->port_stats[i]);

	kfree(sge->tx_sched);
	free_tx_resources(sge);
	free_rx_resources(sge);
	kfree(sge);
}

/*
 * Allocates new RX buffers on the freelist Q (and tracks them onthe freelist
 * context Q) until the Q is full or alloc_skb fails.
 *
 * It is possible that the generation bits already match, indicating that the
 * buffer is already valid and nothing needs to be done. This happens when we
 * copied a received buffer into a new sk_buff during the interrupt processing.
 *
 * If the SGE doesn't automatically align packets properly (!sge->rx_pkt_pad),
 * we specify a RX_OFFSET in order to make sure that the IP header is 4B
 * aligned.
 */
static void refill_free_list(struct sge *sge, struct freelQ *q)
{
	struct pci_dev *pdev = sge->adapter->pdev;
	struct freelQ_ce *ce = &q->centries[q->pidx];
	struct freelQ_e *e = &q->entries[q->pidx];
	unsigned int dma_len = q->rx_buffer_size - q->dma_offset;

	while (q->credits < q->size) {
		struct sk_buff *skb;
		dma_addr_t mapping;

		skb = dev_alloc_skb(q->rx_buffer_size);
		if (!skb)
			break;

		skb_reserve(skb, q->dma_offset);
		mapping = pci_map_single(pdev, skb->data, dma_len,
					 PCI_DMA_FROMDEVICE);
		skb_reserve(skb, sge->rx_pkt_pad);

		ce->skb =


given generation.
 */
static inline void write_tx_descs(struct adapter *adapter, struct sk_buff *skb,
				  unsigned int pidx, unsigned int gen,
				  struct cmdQ *q)
{
	dma_addr_t mapping, desc_mapping;
	struct cmdQ_e *e, *e1;
	struct cmdQ_ce *ce;
	unsigned int i, flags, first_desc_len, desc_len,
	    nfrags = skb_shinfo(skb)->nr_frags;

	e = e1 = &q->entries[pidx];
	ce = &q->centries[pidx];

	mapping = pci_map_single(adapter->pdev, skb->data,
				 skb_headlen(skb), PCI_DMA_TODEVICE);

	desc_mapping = mapping;
	desc_len = skb_headlen(skb);

	flags = F_CMD_DATAVALID | F_CMD_SOP |
	    V_CMD_EOP(nfrags == 0 && desc_len <= SGE_TX_DESC_MAX_PLEN) |
	    V_CMD_GEN2(gen);
	first_desc_len = (desc_len <= SGE_TX_DESC_MAX_PLEN) ?
	    desc_len : SGE_TX_DESC_MAX_PLEN;
	e->addr_lo = (u32)desc_mapping;
	e->addr_hi = (u64)desc_mapping >> 32;
	e->len_gen = V_CMD_LEN(first_desc_len) | V_CMD_GEN1(gen);
	ce->skb = NULL;
	dma_unmap_len_set(ce, dma_len, 0);

	if (PAGE_SIZE > SGE_TX_DESC_MAX_PLEN &&
	    desc_len > SGE_TX_DESC_MAX_PLEN) {
		desc_mapping += first_desc_len;
		desc_len -= first_desc_len;
		e1++;
		ce++;
		if (++pidx == q->size) {
			pidx = 0;
			gen ^= 1;
			e1 = q->entries;
			ce = q->centries;
		}
		pidx =Synthesis and biological evaluation of flexible and conformationally constrained LpxC inhibitors.
Inhibitors of the UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase (LpxC) represent promising candidates for the development of antibiotics possessing a so far unexploited mechanism of action. In a chiral pool synthesis, starting from the D-mannose derived mannonolactone 4, conformationally constrained C-glycosidic as well as open chained hydroxamic acids with a defined stereochemistry were prepared. Diversity was introduced by performing C–C coupling reactions like the Sonogashira and Suzuki cross-coupling reactions. The biological evaluation of the synthesized compounds revealed that in the case of the C-glycosides a long, linear and rigid hydrophobic side chain is required for antibiotic activity against E. coli. The open chain derivatives show higher biological activity than the conformationally constrained C-glycosides. The morpholinomethyl substituted open chain derivative 43, being the


"THE LORD OF THE RINGS" "THE TWO TOWERS" "May they find peace after death." "Something's out there." "What do you see?" "# An evil death has set forth the noble warrior..." "# A song shall sing sorrowing minstrels... # ...in Meduseld that he is no more." "# That he is nowhere anymore, for his necessary rest." "# And that he is the dearest kinsman." "Killing took him..." "Be thou well." "Go-thou, Theodred." "Go-thou." "Steady, quiet now." "Steady." "A battle appraoches." "They know." "What is your name?" "Your name is kingly." "What troubles you, Brego?" "What did you see?" "You told me once... this day would come." "This is not the end... it is the beginning." "You must go with Frodo." "That is your path." "My path is hiddenfrom me." "It is already laid before your feet." "You cannot falter now." "Arwen..." "If you trust nothing else... trust this... trust us." "Is this how you would take your leave?" "Did you think you could slip away at first light - unnoticed?" "I will not be coming back." "You underestimate your skill in battle." "You will come back." "It is not of death in battle that I speak." "What do you speak of?" "You have a chance for another life... away from war... grief... despair." "Hail, Sauron, Lord of the Ring, Lord of the Earth!" "It is time." "The ships are leaving for Valinor." "Go now... before it is too late." "Do I not also have your love?" "You have my love, father." "The world is changed..."


r(s) be the second derivative of q(s). What is the first derivative of r(b) wrt b?
3
Let g(f) = 2851*f**2 + 56*f + 11. Let j(c) = 2*c**2 + 5*c - 1. Let o(y) = g(y) - 7*j(y). What is the second derivative of o(p) wrt p?
5674
Let d(r) = -12345*r**2 + 3067*r. Let s(j) = -24710*j**2 + 6135*j. Let w(f) = -5*d(f) + 3*s(f). Find the second derivative of w(q) wrt q.
-24810
Let d be ((21 - 12)/27)/((-2)/(-24)). Find the second derivative of 4*c**2 - d*c**2 - 7*c**3 + 89*c + 45*c wrt c.
-42*c
Let k(u) be the first derivative of -2057*u**6/6 + 3*u**2/2 - 657*u - 674. What is the second derivative of k(v) wrt v?
-41140*v**3
Let z(h) be the second derivative of -3*h**5/10 + 8*h**3 - 2*h**2 + 9*h. LetWelcome to K&S Engineering and Scientific Ltd. K&S Engineering and Scientific Ltd
specialises in the design, development and manufacture of electronic and automation
equipment for industrial use. Visit our "Products" and "Services" pages for more
detailed information.


column;

  border: 1px solid #f00;
}

#title {
  flex: 0 1 auto;
}

#content {
  flex: 1 1 auto;
}

#chat {
  display: flex;
  flex-direction: column;

  border: 1px solid #00f;
}

#chatmessages {
  flex: 1 1 auto;
}

#chatbox {
  flex: 0 1 auto;
}

Panel title

Hello World

Hello World

Hello World

Hello World

Hello World

Hello World

Hello World

Hello World

Hello World

Hello World

Hello World

<input value="this will be a chat box" />

https://jsfiddle.net/wh5sq6fw/7/
And attached is an image of what I want to achieve in the 2 cases
I hope this is clear enough, let me know if there is anything I can clarify
Thanks

A:

The #content, #chat, #chatmessages need a height, and I removed the #content div and a couple of rules/properties and added overflow: auto to #chatmessages

div {
  user-select:none;
  cursor: default;
}
#panel {
  height: 150px;
  display: flex;
  flex-direction: column;
  border: 1px solid #f00;
}
#chat {
  flex: 1;
  display: flex;
  flex-direction: column;
}
#chatmessages {
  flex: 1;
  overflow: auto;
  border: 1px solid #00f;
}

    Panel title

Hello World

Hello World

Hello World

Hello World

Hello World

Hello World

Hello World

Hello World

Hello World


which can now be incremented to 3 and D can be split to D' and E.
 The contents of the split bucket D, , has been re-keyed with 3 bits, and it ends up in D.
 K4 is retried and it ends up in E which has a spare slot.

Now,  is in D and  is tried again, with 3 bits 011..,  and it points to bucket D which already contains  so is full; D's local depth is 2 but now the global depth is 3 after the directory doubling, so now D can be split into bucket's D' and E, the contents of D,  has its   retried with a new global depth bitmask of 3 and  ends up in D',at the bottom of the page and work from there. This is how I would quickly resolve the issues until I could properly fix it!

Thanks a lot Danny that fixed the problem but now I have a new problem.

If you scroll down all the way to the bottom on http://easource.com you will see that the #bottom-container image can not be completely seen. I want to decrease the height of the container so that the #bottom-container bg image can be seen in its entirety.


Q:

Does CFBridgingRelease restore ownership to preexisting references without direct assignment?

If I have the following code:
// objective C++ code .mm
id<MTLTexture> texture = ...;
void* ptr = (void*)CFBridgingRetain(texture);
share_ptr_with_native_code(ptr);
[texture do_stuff]; // is this valid?

// native code .cpp
void share_ptr_with_native(void* ptr)
{
  ptr->do_stuff();
  CFBridgingRelease(ptr);
}

Will texture be valid and retained by ARC again after the call to share_ptr_with_native()?

A:

Other than various errors in your code snippet, yes, the line in question is valid. ARC continues to maintain its own strong reference to object while it's still in use in the top code, in addition to the one that you become responsible for. CFBridgingRetain() has a +1 effect on the retain count of the object, hence "retain" in its name.

Simulated astigmatism impairs academic-related performance in children.
Astigmatism is an important refractive condition in children. However, the functional impact of uncorrected astigmatism in this population is not well established, particularly with regard to academic performance. This study investigated the impact of simulated bilateral astigmatism on academic-related tasks before and after sustained near work in children. Twenty visually normal children (mean age: 10.8 ± 0.7 years; six males and 14 females) completed a range of standardised academic-related tests with and without 1.50 D of simulated bilateral astigmatism (with both academic-related tests and the visual condition administered in a randomised order). The simulated astigmatism was induced using a positive cylindrical lens while maintaining a plano spherical equivalent. Performance was assessed before and after 20 min of sustained near work, during two


the inherent faintness of the sources at all shorter wavelengths. The radio regime has emerged as an efficient means to pin-point the sub-mm sources (through the FIR/radio relation, e.g. Helou et al. 1985; Condon 1992), however when radio emission cannot be detected, the only recourse is to use millimeter interferometry to attempt to localize the source.

The first well-studied sub-mm system SMMJ02399–0136 (hereafter SMMJ02399) at $z=2.8$ was shown to contain both an AGN (Ivison et al. 1998) and a massive reservoir of molecular gas thought to be fueling a starburst (Frayer et al. 1998). This scenario is increasingly becoming the conventional paradigm for the sub-mm population. This is perhaps unsurprising, given that both AGN and starbursts are thought to be triggered by galaxy interactions (e.g. Sanders et al. 1988, Archibald et al. 2002). With the proliferationSED. The 50CCD-clear filter is roughly a Gaussian with 1840Å halfwidth and an effective wavelength of 5733.3Å. We refer to the associated AB magnitude as $R'(573)$ hereafter. The STIS image is presented in Fig. 1 with a Ly$\,\alpha$ outline overlaid (Bower, private communication). The relative astrometry was carried out by matching all bright sources, providing a relative positional error of 0.28.

Whereas no optically detected continuum sources were present within the core of the Ly$\,\alpha$ cloud from the $R\sim26$ ground based imagery in Steidel et al. (2000), we find several compact and distorted sources in the deep [*HST*]{}-STIS imagery (Fig. 1), labeled J1, J2, J3 and J4. However, comparison of our [*HST*]{} image with the Ly$\,\alpha$ contours from Steidel et al. (2000) and Bower et al. (2004), suggests that these [*HST*]{} sources do not always


– putatively all induced by the AGN jet – but each essentially unresolved by STIS.

The unresolved peak within the linear structure of J1 is at least suggestive of an AGN, although without other diagnostics, we cannot rule out a compact starburst. The apparent limit on the X-ray emission is not sufficient to rule out an obscured AGN. Spatially resolved spectroscopy along the axis of the linear feature could in principle differentiate emission mechanisms, however, the fragment is extremely faint in the optical and our present Keck-LRIS spectrum likely represents the best practical quality achievable with a 10m class telescope.

Molecular gas
-------------

The limit on the integrated [CO(4–3) ]{}line flux from the marginal detection of the ‘Blob’ represents $S({\rm CO})\,<\,2.5\,{\rm Jy}\,{\rm km}\,{\rm s}^{-1}$. No adjustment has been made to account forthe continuum level since it appears to be negligible. The observed [CO(4–3) ]{}line flux (peaking at $\sim 5$mJy) implies an intrinsic CO line luminosity $L^{\prime}({\rm CO}) = 7.5\times 10^{10} {\,\rm{K}\,\rm{km~s}^{-1}\,{\rm pc}^{2}}$ (see the formulae in Solomon, Downes, & Radford 1992). The CO luminosity is related to the mass of molecular gas (including He) by $M({{\rm H}_2})/L^{\prime}({\rm CO}) = \alpha$, with the value for $\alpha$ expected to be $\simeq 1 {\,M_{\odot}}({\,\rm{K}\,\rm{km~s}^{-1}\,{\rm pc}^{2}})^{-1}$, consistent with that estimated for local ultraluminous infrared galaxies (ULIGs; Solomon et al. 1997). We then adopt a correction for the excitation CO(4–3):CO(1–0) brightness ratio of $\simeq0.5$ typically observed in starbursts (Devereux et al. 1994), yielding $\alpha=2 {\,M_{\odot}}({\,\rm{K}\,\rm{km~s}^{-1}\,{\rm pc}^{2}})^{-1}$. The inferred limit on the molecular gas mass of the ‘Blob’ is $2 \times 10^{10} M_{\sun}$, which is consistent with


– containing strong dust and Ly$\,\alpha$ emission coexisting in an environment that shows no unambiguous signs of AGN activity. A buried AGN may be the most likely explanation from energetic grounds alone, but this needs to be confirmed through some clear sign of AGN activity. High ionization lines in the mid-IR ($\sim$15[$\,\mu$m]{}) may be detectable in the ‘Blob’ with [*SIRTF*]{}-LWS if excited by a dust-obscured AGN (see e.g., Rigopoulou et al. 1999). It might still be that cooling radiation from a forming halo plays a role (Fardal et al. 2001). Further data will be required to determine whether multiple processes contribute to the Ly$\,\alpha$ emission, and how these are related to the sub-mm source. Meanwhile it is worth investigating the relationship between Ly$\,\alpha$ and sub-mm emission for a wider sample2009-2013: $31,476

> State median household income, 2009-2013: $49,774

> Poverty rate, 2009-2013: 36.2%

> Unemployment, 2013: 19.8%

Residents of Arizona's poorest county clearly struggled with poverty over the five years through 2013. Apache County's poverty rate of more than 36% was more than double the national rate of 15.4% and one of the highest among states' poorest counties. Apache also had one of the highest unemployment rates in 2013, at nearly 20%.

4. Lee County, Arkansas

> County median household income, 2009-2013: $25,034

> State median household income, 2009-2013: $40,768

> Poverty rate, 2009-2013: 31.5%

> Unemployment, 2013: 11.2%

During the five years through 2013, Arkansas had a median annual household income of less than $41,000, lower than in every state except for Mississippi. A typical household in Lee County, the state's poorest, earned nearly $16,000 less


$44,927

> Poverty rate, 2009-2013: 22.6%

> Unemployment, 2013: 6.2%

Like in most of New Mexico, Sierra County residents earned relatively little compared to most Americans. County households had a median annual income of $27,430 between 2009 and 2013, nearly half the national income of $53,046. However, the county's job market, as measured by unemployment, was relatively strong. Just 6.2% of the area's workforce was unemployed in 2013, lower than the national rate.

32. Bronx County, New York

> County median household income, 2009-2013: $34,388

> State median household income, 2009-2013: $58,003

> Poverty rate, 2009-2013: 29.8%

> Unemployment, 2013: 11.8%

Less than 70% of adults living in the Bronx had attained at least a high school diploma, one of the lowest attainment rates in the country. Poor education among residents likely contributed to the area's lowof Athens County residents lived in poverty over the five years through 2013, more than double the national figure of 15.4%. While children are almost always more likely to live in poverty than adults in the United States, this was not the case in Athens County, where nearly 29% of children lived in poverty. However, this rate was much higher than the comparable national rate of 21.3%. County households had such low incomes that owning a home was also out of reach for many area residents. Over the five years through 2013, less than 57% of housing units were owned by occupants, versus the national homeownership rate of 64.9%.

36. Pushmataha County, Oklahoma

> County median household income, 2009-2013: $29,897

> State median household income, 2009-2013: $45,339

> Poverty rate, 2009-2013: 26.5%

>


named inhibin binding protein or p120.[@R5] However, IGSF1's putative role as an inhibin co-receptor has been challenged by more recent binding and in vivo data.[@R6]^,^[@R7] Thus, IGSF1's function in normal physiology has remained undefined.

Immunoglobulin domains are commonly found in eukaryotic proteins (e.g., in 765, 142 and 80 human, fly and roundworm proteins, respectively).[@R8] Most members of the immunoglobulin superfamily (IgSF) are cell adhesion molecules (CAMs) and regulate signaling by cell surface receptors through modification of target recognition, differentiation and specialization of membrane microdomains and initiation and organization of signaling platforms.[@R8] They can bind other IgSF members (homophilically or heterophilically) as well as other molecules.[@R8]

The disproportionate increase in numbers of IgSF members from invertebrates to vertebrates parallels the evolution of the adaptive immune system.[@R9] Indeed, many members (e.g., CD226,long dispute amongst Navy officials. Franklin Roosevelt left Brooklyn, New York, on a destroyer for an inspection trip in Europe in July of 1918. He inspected installations in England, France, and Italy until September. When he returned to New York, he once again became seriously ill with influenza. Three months later, after overcoming the illness, Roosevelt sailed on the George Washington with his wife. The boat was headed for Europe on a mission to dismantle American Navy installations. On the way to Europe, they stopped in Boston and had a luncheon meeting with Wilson. Wilson convinced Roosevelt that the United States had to join the League of Nations.The influence of FDR is evident in the fact that the President of the United States felt the need to acquire


his goal of becoming President. July 1, 1932, Roosevelt was nominated for President of the United States on the fourth ballot. He won the election on November 8, and in 1933, FDR was inaugurated. During his first “Hundred Days,” as the first three months have come to be known, many important events occurred under Roosevelt’s leadership. One act of extreme importance was the Emergency Banking Relief Act. This movement placed banks under federal control and provided for their re-opening. Also, the Economy Act was signed, which saved about $243 million. During this time, Roosevelt signed a bill establishing the Civilian Conservation Corps. to create employment for young men and to aid in reforestation work. Another extremely important decision was his request that Congress create a Tennessee Valley Authority,which proved to be very useful. During the “Hundred Days,” Roosevelt signed the Johnson-O’Malley Act, which provided federal aid to states for Indian welfare. The United States also eliminated the gold standard, hence raising domestic prices. He signed the Federal Securities Act, which provided regulations to require full disclosure to investors on new securities. Lastly, he signed the National Industrial Recovery Act (NIRA), which created today’s National Recovery Administration (NRA). This supervised industry’s attempt at self-regulation by establishing fair trade in competition.FDR also published another book in 1934 entitled, On the Way. Roosevelt’s first term was very successful as he finally got a chance to implement his own ideas, and the people began to have faith in his decisions. Proof is in the fact that many people attributed


       2011-04-06      2011-05-26
103 100030      9               2011-05-26      2011-05-26
104 100030      11              2011-09-29      2011-05-26
105 100030      6               2011-10-29      2011-05-26

Any suggestions???

A:

@Yoismel All I did was add an ORDER BY and LIMIT clause to your answer.  Your answer does not guarantee that the date returned is the most immediate next date.19% decrease between 2006 and 2008 in childhood pneumonia using hospital episodes statistics (HES) data. The reduction in the rate of hospitalization was more than that reported in Canada of 13% in those aged \<5 years following the routine introduction of PCV7 \[[@ref24]\]. The disease incidence is also close to the estimates of other studies of PCV11 in the Philippines \[[@ref25]\] and PCV7 in the USA \[[@ref9]\] that reported decreases in all-cause pneumonia by about 22%. It is, however, lower than the 25% reduction against radiological pneumonia reported in randomized controlled trial of PCV9 in South Africa \[[@ref7]\] and 30% in the USA \[[@ref26]\]. This may be a reflection of the differences in pneumococcal disease between populations or in adherence and vaccine usage in our population compared to


*et al*. \[[@ref27]\].

This survey has demonstrated a reduction in all-cause pneumonia. Previous estimates have suggested around 10% of childhood pneumonia is attributable to *S. pneumoniae* in the UK \[[@ref5], [@ref6]\]. Given the decline in pneumonia and assuming the absence of other changes in disease or admission procedures, it seems likely that 10% is a significant underestimation of the true burden of pneumococcal-related childhood pneumonia in the UK \[[@ref1], [@ref28]\]. It is only recently that any studies have been able to describe the relative contributions of different pneumococcal serotypes in paediatric pneumonia \[[@ref29]\], and these have not yet been established in UK children. At the moment the pneumococcal serotype distribution in childhood pneumonia in the UK has only been inferred from surveillance of invasive pneumococcal disease by the Healthinvestigations into this scam may be a top priority with the FIA, all eyes are on what happens to Bol.

Image copyright AFP Image caption The ground appears to be slipping from under Axact's impressive multi-storey office building in Karachi

The minute the NYT report hit the stands on 17 May, Pakistani TV channels went into overdrive in an apparent bid to drag down Bol, a menacing looking potential rival that Axact bosses said would change Pakistan's media landscape.

It was an uneasy reminder of the convulsive media wars of last year when most news channels ganged up to drag down Geo TV.

These wars are in turn a throwback to the lawyers' movement of 2007, when the media and protesters ganged together in common cause to weaken, and subsequently oust military


analysis of SNP-depleted transcripts performed with the DAVID tool revealed three distinct classes of overrepresented GO terms ([Table 2](#tab2){ref-type="table"}). The first class was associated with*transcription regulation*. The second consisted of GO terms related to*chromatin organization*. Notably, these two classes define two extremely important biological processes, transcription regulation by transcription factors, and regulation of chromatin packaging. Both biological processes were overrepresented in four or more sets of SNP-depleted transcripts, indicating that this finding was highly reliable. The third class, smaller than the two, listed terms that described a highly tissue-specific process of male gamete generation (spermatogenesis). We considered this class of GO terms because terms related to male gamete generation were found for*SNP-depleted datasets* of transcripts with very long 5′-regions (\[−900; +100\], \[−800; +100\], and \[−700; +100\]). Such extendedintracellular conditions or external stimuli \[[@B30]\].

Thus, both classes of proteins are involved in the complicated process of transcriptional control, ensuring correct expression of specific genes. Both so called "transcription factor-binding regulatory code" and "histone code" may be effectively used for prediction of gene expression activity. Moreover, these codes are redundant for predicting gene expression \[[@B31]\]. This redundancy means that TFs and chromatin-modifying proteins function in close cooperation, facilitating the recruitment of each other to transcription complexes. The numerous protein-protein interactions revealed between TFs and chromatin-modifying proteins convincingly prove this idea \[[@B32], [@B33]\].

The transcriptional regulatory system plays the central role in controlling many biological processes, ranging from cell cycle progression and maintenance of intracellular metabolic and physiological balance, to cell differentiation and developmental time courses. Numerous diseases arise from


genes encoding TFs and chromatin-modifying proteins, we calculated RVIS values. According to cumulative percentage plots for the RVIS percentiles ([Figure 6(a)](#fig6){ref-type="fig"}), both groups showed reduced intolerance to functional variation, confirming our hypothesis that a low level of promoter polymorphism may have resulted from purifying selection.

4.4. The Differences between Superclasses of TFs {#sec4.4}
------------------------------------------------

According to [Figure 3(a)](#fig3){ref-type="fig"}, TFs have reduced SNP contents in their 5′-regulatory regions. In addition, we found sharp differences between four sets of transcripts/genes encoding TFs with DBDs of specific types. For two groups of genes encoding TFs (TFs with helix-turn-helix DBDs (HTH superclass) and TFs with DBDs of seven other superclasses (with the exception of the largest ones*ZNF, HTH,* and*Basic*; see [Section 2](#sec2){ref-type="sec"})), the differences against the whole-genome dataset were highly significant in a wide rangethe elutriation technique. The total ECL cell number was twofold higher in hypergastrinemic rats than in normogastrinemic rats, and most of the cells appeared in elutriation fractions where large cells predominate. The ECL cells of the different fractions were analyzed by quantitative electron microscopy. Normal-sized ECL cells from hypergastrinemic rats displayed a reduced number of secretory vesicles (probably because of degranulation) compared with normal-sized ECL cells from normogastrinemic rats. Hypertrophic ECL cells from hypergastrinemic rats had an unchanged number of secretory vesicles, supporting the view that such cells fail to respond to gastrin with degranulation. Although both normal-sized and hypertrophic ECL cells from hypergastrinemic rats contained vacuoles, those in the hypertrophic ECL cells were larger and more numerous. In addition, hypertrophic ECL cells were found to contain numerous,


 nums_[i] = val;
            updateHelper(root_, i, val);
        }
    }

    int sumRange(int i, int j) {
        return sumRangeHelper(root_, i, j);
    }

private:
    vector<int>& nums_;

    class SegmentTreeNode {
    public:
        int start, end;
        int sum;
        SegmentTreeNode *left, *right;
        SegmentTreeNode(int i, int j, int s) :
            start(i), end(j), sum(s),
 == 0) {
    arbitration_lost();
  }
  // SCL is high, set SDA from 1 to 0.
  clear_SDA();
  I2C_delay();
  clear_SCL();
  started = true;
}

void i2c_stop_cond(void){
  // set SDA to 0
  clear_SDA();
  I2C_delay();
  // Clock stretching
  while (read_SCL() == 0) {
    // add timeout to this loop.
  }
  // Stop bit setup time, minimum 4us
  I2C_delay();
  // SCL is high, set SDA from 0 to 1
  if (read_SDA() == 0) {
    arbitration_lost();
  }
  I2C_delay();
  started = false;
}

// Write a bit to I2C bus
void i2c_write_bit(bool bit) {
  if (bit) {
    read_SDA();
  } else {
    clear_SDA();
  }


Write a byte to I2C bus. Return 0 if ack by the slave.
bool i2c_write_byte(bool send_start,
                    bool send_stop,
                    unsigned char byte) {
  unsigned bit;
  bool nack;
  if (send_start) {
    i2c_start_cond();
  }
  for (bit = 0; bit < 8; bit++) {
    i2c_write_bit((byte & 0x80) != 0);
    byte <<= 1;
  }
  nack = i2c_read_bit();
  if (send_stop) {
    i2c_stop_cond();
  }
  return nack;
}

// Read a byte from I2C bus
unsigned char i2c_read_byte(bool nack, booli2c_start(void)
{
unsigned int i;

SDA_TRIS = 1;                   // ensure SDA & SCL are high
SCL = 1;
SDA_TRIS = 0;                   // SDA = output
SDA = 0;                        // pull SDA low
for (i=0;i<2;i++) NOP();
SCL = 0;                        // pull SCL low
}

//....................................................................
// This function generates an I2C Stop Condition
//....................................................................
void i2c_stop(void)
{
unsigned int i;

SCL = 0;


      // configure SDA as an input
SCL = 1;                        // bring SCL high to begin transfer
for (i=0;i<3;i++) NOP();
*data |= SDA;                   // input the received bit
SCL = 0;                        // bring SCL low again.
}

//....................................................................
// Writes a byte to the I2C bus
//....................................................................
unsigned char i2c_wr(unsigned char data)
{
unsigned char i;              (1 << I2C_DAT);

#define I2C_CLOCK_HI()\
I2C_DDR &= ~ (1 << I2C_CLK);\
I2C_PORT |= (1 << I2C_CLK);
#define I2C_CLOCK_LO()\
I2C_DDR |= (1 << I2C_CLK);\
I2C_PORT &= ~ (1 << I2C_CLK);

void I2C_WriteBit(unsigned char c)
{
    if (c > 0)
    {
        I2C_DATA_HI();
    }
    else
    {
        I2C_DATA_LO();
    }

    I2C_CLOCK_HI();
    delay(1);

    I2C_CLOCK_LO();
    delay(1);

    if (c > 0)
    {
        I2C_DATA_LO();
    }

    delay(1);
}

unsigned char I2C_ReadBit()
{
    I2C_DATA_HI();

    I2C_CLOCK_HI();
    delay(1);


This Court has before it the petition for appeal, all matters of record and the briefs and argument of counsel.
This appeal concerns two different actions, Nelson Plumbing Company v. Lakeview Estates, Inc., et al. (Civil Action No. 9508, filed on February 16, 1968 in Wood County) and Perlick and Company v. Lakeview Creditors Trustee Committee, et al. (Civil Action No. 80-C-1512-B filed on November 25, 1980). The latter is the action from which this appeal is taken.
On May 27, 1966, Perlick, the appellant, entered into a contract with the appellee, Lakeview Estates, (hereinafter "Lakeview"), to supply plumbing fixtures and other materials for a construction project. A substantial portion of Perlick's obligation under the contract was subcontracted to the Nelson Plumbing Company (hereinafter "Nelson"). In June of 1967 Lakeviewdispute would be settled by arbitration, pursuant to the rules of the American Arbitration Association.
According to Paragraph 7.2[5] of the Agreement if Perlick's claim was approved by the Trustee Committee Lakeview would issue a "Participation Certificate" in the amount of Perlick's approved claim. According to Paragraph 8.1[6] of the Agreement only when a creditor, who was listed in Schedule "A," received a proper Participation Certificate did it "release, settle and acknowledge to be fully satisfied, any and all rights, claims, demands or causes of action" it may have had against Lakeview.
On April 19, 1968, Hider, of the Trustee Committee, once again wrote to Perlick stating that the Committee was reviewing Perlick's claim. According to that letter when the Committee and Perlick agreed on the claim's validity and amount


a signed sentence using available upper body movement and facial expressions of various types and intensity. A specific translation effort has to be made every time new content is generated, whether it is a new web page, television announcement, or conversation. A human sign language interpreter also has to be hired for a meeting between deaf and hearing individuals, spelling out a conversation via teletype equipment (TTY) or in other interactions.
Therefore, there is a need for a system that includes a graphical computer agent that is used to convey content in sign language, where the agent can convey at the same time a presentation of sound or text corresponding to sounds and words from a third party. A graphically depicted agent brings consistency and visual advantages that athe jury that the district court either favored the government's case or disparaged the defense.  Even assuming for purposes of analysis that the district court's comments were prejudicial, these comments did not "pervade[ ] the overall fairness of the proceedings."  United States v. Bland, 697 F.2d 262, 265 (8th Cir.1983) (footnote omitted).

PROSECUTION COMMENTS

6
Jackson also argues the district court erred in denying his motion for mistrial because of prosecutorial misconduct.  During the rebuttal portion of closing argument, the prosecutor repeatedly noted Jackson's prior criminal record.  The district court interrupted the prosecutor and told the prosecutor to pursue a different line of argument.  At the end of the closing argument, defense counsel objected and moved for a mistrial on the ground of prosecutorial misconduct.


ultrasound, having several X-rays taken and having scope with a camera put down his throat, BluePearl internal medicine specialist Dr. Brian Luria discovered the giant hairball. It was too large to remove with the scope, so surgery was necessary.

Dr. Mike Reems, a board-certified surgeon from BluePearl Veterinary Partners and Dr. Don Woodman, owner of Animal Hospital of Northwood in Safety Harbor pulled out the clump of hair. It weighed 4.015 pounds.

"I'm just extremely thankful for the help Dr. Woodman, Dr. Reems and the staff at BluePearl provided," Vernon Yates, founder of Wildlife Rescue and Rehabilitation Inc., said in a press release.

Hairballs are a natural byproduct of the feline grooming process, the American Society for the Prevention of Cruelty to Animals points out. When a cat is grooming themselves,not occur, I implore the governor to dismiss the damaging and ineffective members of this board and make staff — and community — supported appointments,” Hiller said.

Jon Starkey, Gov. Carney’s communications director, said the governor visited Sussex Tech recently and is aware of the situation. His office will continue to monitor it.

EDUCATION DELAWARE

School safety panel held one month after Middletown High student arrested with gun

Delaware teens, youth advocates want to see more diversity in their classrooms

Wilma Mishoe named president of Delaware State University

Contact Jessica Bies at (302) 324-2881 or jbies@delawareonline.com. Follow her on Twitter @jessicajbies.

Looking for more education news? Visit delawareonline.com/education. Submit story ideas at delonline.us/2i2tugB.


Silicon nitride is frequently utilized in modern semiconductor fabrication methods. For instance, silicon nitride is an insulative material, and can be utilized to electrically isolate conductive components from one another. Also, silicon nitride is selectively etchable relative to other materials utilized in semiconductor fabrication processes, such as, for example, silicon dioxide, and is can thus be utilized as an etch stop material. Another example use of silicon nitride is for LOCOS (LOCal Oxidation of Silicon). LOCOS comprises growing oxide over field regions of a semiconductor substrate, while not growing the oxide over other regions of the substrate. The other regions of the substrate are typically protected by a thin layer of silicon nitride during the oxide growth.
In many applications of silicon nitride, a silicon nitride layer is patternedour users, but we're also excited about what it means for business owners. By default, users looking for local businesses can easily view ratings for your business, reviews, related maps, find nearby transit options showing them how to get to you, and take a look at your business with a Street View preview - and it's all on one page. If you claim your listing with the Local Business Center, you'll be able to make sure there's even more rich content on the Place Page, like photos, YouTube videos, hours of operation, types of products or services offered, and several other categories you can submit. You can even add a coupon that will appear on your Place Page to really entice potential customers. By editing your Local Business


include a host of modern songwriters from the pop, country, and rock spheres. Along with Gaga and Cooper, there’s contributions from Jason Isbell, Willie Nelson’s son Lukas, Mark Ronson, Miike Snow frontman Andrew Wyatt, behind-the-scenes pop wizards Julia Michaels and Justin Tranter, the list goes on. The songs fall into a few distinct silos—blaring blues-rockers, tender acoustic ballads, anthemic torch songs, and robotic electro-pop—and save for a digital flourish or two on the pop songs that make up much of the film’s back half, there’s very little here that would’ve sounded out of place on blockbuster film soundtracks of decades past.

At its peaks, the album delivers on the promise of its star-wattage with some of the most affecting and emotionally overwhelming pop songs of the year. If you’vethe one and only We2 breakfast you will enjoy significant savings! From We2 to you!

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Corporate Image, Panamericana - Art And Design School Adverts.

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OBAMA IN OSLO

November 2014

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OBAMA IN OSLO

Anmeb, based at Rio de Janeiro, Brazil has been asked to develop OBAMA IN OSLO for their brand NarvesenProduct: Newsagent in 2009. This campaign is known in the marketing & communication market for Commercials Archive, DM, Corporate Image, Narvesen Adverts.

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Lennon

November 2014

November 2014

Lennon

MaVi Brasil, based at Nova Nazaré, Brazil has been asked to develop Lennon for their brand Lexical English School in 2009. This customer case is known in the marketing & communication market for Print, Commercials Archive, Consumer, Public services, Lexical English School Adverts.

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World Diabetes Day

Novembera flute or saxophone player sat in in with the Grateful Dead, people have always asserted that it was Charles Lloyd. This gets repeated so often that it became gospel, and the archive site lists Charles Lloyd as the guest on Aug 21 (with a question mark), with similar (albeit skeptical) comments on June 13, 1969 in Fresno and August 3 at The Family Dog.

In fact, I think there is a lot less evidence that Charles Lloyd played with the Grateful Dead after 1967, much as he may have wanted to, and that the flute player on the August 21 Seattle show and the June 13 Fresno show was actually one of the horn players for the group San Paku, although I have not been able to determine


halted. Those shows that took place whilst Bill Graham held the lease (July 5, 1968 to July 4, 1971) but were not promoted by Graham still utilised the Carousel Ballroom name.

An interesting point is that if Bill Graham had have waited a further week before putting on shows at the Carousel, the final weekend would have seen Jimi Hendrix and BB King performing. The artwork for Rick Shubb's poster is currently being restored and will miraculously appear at a later date. There was at least one month's notice given for the cancellation.

I have added the May 22 listing but have so far I have been unable to add any other details. Mr Cooke's name has been amended. Interestingly, whilst looking May 22 show I found details that itBe-In.

There are a lot of mysteries, because everyone was high. Could the Airplane guest have been Quicksilver equipment manager Steven Schuster (better known as Jack Bonus)? I believe Schuster married Ginger Jackson, who was an old housemate of Kantner's (and Crosby, Freiberg, etc).

Over on dimeadozen, someone has raised the possibility that the electric violinist on August 3, 1969 was Jerry Goodman of The Flock (later of Mahavishnu Orchestra). Although The Flock were Chicago-based, this isn't as far fetched as it might sound. The Flock were touring California in the month of July, and had played Fillmore West fairly recently (July 22-24, opening for Ike & Tina).

Of course, it seems more likely they would have a weekend show outside of San Francisco, but maybe they were hanging around on


harbored chromosomal amplifications and deletions, and these alterations were more frequent in metastatic specimens (recurrent liver tumors, metastatic lymph nodes, and peritoneal metastases) compared with primary tumors. We additionally demonstrated by transcriptome analysis that metastatic tumors closely resembled the gene expression profile of the corresponding primary tumor. Furthermore, we found evidence by both aCGH and RNA-seq that p53 tumor suppressor pathway genes were significantly downregulated. Overall, Notch, EGFR, NRAS, and RB1 pathways were also dysregulated in FL-HCC.

Patients and methods {#sec002}
====================

Patient and sample selection {#sec003}
----------------------------

Patient data and specimens were collected under approval of the Memorial Sloan Kettering Cancer Center Institutional Review Board. Tumor specimens were available from 32 patients who underwent surgery for FL-HCC between 1993 and 2012 and who provided informed consent for specimen research studies. Representative histologicmovement relative to a piece of sheet material on which they are mounted. Therefore when a cooperating fastening element engages the sheet material mounted fastener, the cooperating element may pull the mounted fastener out of the sheet material and/or may rotate the mounted fastener relative to the sheet material. This is especially true when one of the threaded elements has a locking feature.


few throughout history have ever suffered before.”

READ MORE: ‘War will destroy everything you own,’ head of Iran’s elite troops warns Trump

Australia, a member of global intelligence alliance known as the Five Eyes, is reportedly poised to play a part in the operation, providing its defense facilities to identify targets in Iran. The same assistance may be offered by the UK, while two other parties in the alliance – Canada and New Zealand – “would be unlikely to play a role in any military action in Iran,” according to ABC.

However, the outlet’s security sources noted the significant difference between a country directly participating in a mission, and providing intelligence on Iranian facilities.

Read more

“Developing a picture is very different to actually participating in a strike,” the unnamed security source said.

Australian           // Here you will add your events to your new row
});

// this function will add your events to a specific row
function addEventsToRow(tr)
{
    tr.addEventListener('mouseover',function(e){
        $(this).css('height','40px');
        $(this).css('background','orange');
        $(this).css('transform','scale(1.05)');
    })
    tr.addEventListener('mouseout',function(e){
            $(this).css('height','');
            $(this).css('background','');
            $(this).css('transform','');
        })
}

// here you will add your events to your tables default rows.
 var


this to my son when he finally had the
courage enough to come out of his silence and expose the bully!!! Someone
please have a heart and fight for my son’s so that I might feel that I can
trust the school system again.(or academics) with the tools necessary to perform the “down and dirty” analyses that take into account the complex and changing nature of our economy. [2]

Seeing no reason why they ought to have succeeded, we’re perhaps a little more forgiving (than Mr. Johnson) of economists’ shortcomings. But we share his concerns that mathematical sciences are being too directly applied, that the practices and the incentives are being largely ignored.

On Endlessly Assuming “Mean Reversion”Rather, we ought to encourage our researchers to go into the proverbial field – and to learn to think, and study dynamics, differently.

We can no longer allow ourselves to be informed purely by static analyses of historical data and trends, without seeking a keener appreciation for the underlying dynamics at play. The lazy assumption of mean


it's just too complicated. We don't really have the quantitative tools to do that." Source

1 comment:

This study adds to the literature on mean aversion and mean reversion in housing prices. In contrast with the previous related literature, the persistence and reversion characteristics are studied by computing variance ratios using Kim's (2006) Wild bootstrapping and by investigating horizons up to 10 years. The variance ratios clearly indicate that housing prices do not follow random walk in any of the 15 Finnish cities included in the analysis. Instead, momentum in housing price growth is longlasting and considerable in size. Since the eventual reversion is substantially weaker than the initial mean aversion, housing is notably riskier asset in the long term than suggested by variances computed from quarterly or annual pricemovements. The results also show that the momentum and reversion patterns may substantially vary between regional housing markets. These differences influence the optimal housing portfolio allocation and highlight one more reason why it is complicated to use country level housing price data when analyzing the optimal portfolio allocation or housing price dynamics.


indicted appellee

on one count of aggravated vehicular assault in violation of R.C. 2903.08(A)(1)(a), and

two counts of driving a motor vehicle while under the influence of alcohol in violation of

R.C. 4511.19(A)(1)(a) and (f).

       {¶3}   On May 16, 2014, appellee filed a motion to suppress, claiming, among

other things, an involuntary consent because she had never been placed under arrest.

Hearings were held on September 26, and October 27, 2014. By judgment entry filed

January 23, 2015, the trial court granted the motion and suppressed the results of the

blood draw, finding no evidence of a lawful arrest.

       {¶4}   Appellant, the state of Ohio, filed an appeal and this matter is now before

this court for consideration. Assignment of    The trial court in the case sub judice declined to suppress the blood

      draw on the basis that Trooper Holloway had the "intent to arrest"

      appellant and that there had been a "constructive seizure" of appellant.

      Judgment Entry at 4.      The transcript of the suppression reveals that

      Holloway himself recalled that he had repeatedly told appellant at the
Delaware County, Case No. 15 CAA 01 0010


in granting the motion to

suppress on the finding that appellee was not lawfully arrested.

       {¶19} The sole assignment of error is granted.
Delaware County, Case No. 15 CAA 01 0010                                       10

       {¶20} The judgment of the Court of Common Pleas of Delaware County, Ohio is

hereby reversed, and the matter is remanded to said court for further proceedings

consistent with this opinion.

By Farmer, J.

Hoffman, P.J. and

Delaney, J. concur.

SGF/sg 821
an evidentiary hearing regarding extrajudicial juror communications. They also contest an enhancement to their sentences for the amount of loss. We affirm their convictions and sentences.

I.

2
To combat staged accidents and automobile insurance fraud, the Federal Bureau of Investigation initiated an undercover operation known as "Soft Tissue." The name derives from soft tissue injuries, which are musculoskeletal injuries that do not necessarily present objective symptoms for diagnosis, unlike bruising or broken bones. Since the symptoms consist primarily of a subjective component (such as complaints of pain) they are easier to fake, and hence favored when making fraudulent claims. Operation Soft Tissue investigated fraudulent car accidents in which conspirators staged accidents and then profited by making claims for damage to the cars and inflated medical bills for individuals, including some


individuals who may not have even been in the cars during the collision.

3
In conducting the investigation, the FBI established a law office for agent James Whitmer, a licensed Illinois attorney. With permission from the Attorney Registration and Disciplinary Commission, an agency of the Illinois Supreme Court, Whitmer posed as attorney "James Kent," whose mission was to find and represent clients in settling fraudulent accident claims with various insurance companies. Assisting the investigation and posing as the office manager was cooperating witness David Youhanna. Youhanna had participated in staging accidents for almost a decade and, after a hiatus from his involvement, agreed to cooperate with the government in the investigation. To ensure that the claims processed through the office were fraudulent, agent Whitmer never advertised, relying instead on Youhanna'ssolicited advice regarding the legality of making claims on a fraudulent accident; rather, the theory at trial was that their portion of the accident was not staged. This is not a situation in which the Al-Shahins relied on the advice of an attorney and proceeded with their conduct. Instead, the Al-Shahins sought representation to further their scheme and facilitate recovery from the insurance. There is simply insufficient evidence to support an advice-of-counsel instruction. Since the advice-of-counsel defense is inapplicable under these circumstances, the district court correctly refused to tender a jury instruction on this defense.

28
Regarding the entrapment defense, the evidence similarly does not support this theory. To obtain an instruction on the entrapment defense, "a defendant must `[produce] sufficient evidence upon which a rational jury could have inferred


review the judge's determination not to hold an evidentiary hearing regarding extrajudicial juror communications for an abuse of discretion. In this case, the district court judge denied an evidentiary hearing, concluding based on the government's submission that "no improper conduct occurred and that there was no prejudice to either of the defendants from the incidents described in the Government's disclosure." The district court judge further concluded that the comments were "innocuous," citing Whitehead, 263 F.3d at 724-25.

36
We were initially curious at the district court judge's finding that "no improper conduct occurred," since jurors are routinely instructed not to speak about deliberations or communicate about the trial, and since a juror's communication would then constitute the improper conduct of violating an instruction. In this case, however, a review oftime of Krystof's termination, Shaw was 47 years old and Krystof was 65 years old.
On April 16, 1992, Krystof filed a charge of age discrimination against Hyatt with the Illinois Department of Human Rights ("IDHR") and the Equal Employment Opportunity Commission ("EEOC"). On June 30, 1992, more than 60 days having elapsed since the filing of his charge, Krystof filed a complaint under the ADEA, claiming that Hyatt discharged him because of his age. On March 31, 1993, Hyatt filed its motion for summary judgment.

DISCUSSION
Rule 56 of the Federal Rules of Civil Procedure requires this court to enter summary judgment on Hyatt's motion "if the pleadings, depositions, answers to interrogatories, and admissions on file, together with the affidavits, if any, show that there is no genuine issue as


is 3 out of 5 or 3 out of 8, these figures provide absolutely no evidence of discriminatory motive.
Third, Krystof's assertion that Hyatt made "telling errors" in its roster of accounting employees remaining employed after the RIF fails to show motive because these errors *494 are minute and do not reflect bad faith on Hyatt's part. Specifically, Hyatt had added one year to the true age of 2 of the 5 oldest employees listed, and added 1 year to the age of Shaw (Krystof's successor). Although these errors are in Hyatt's favor, they do not alter the numbers of employees within the protected class, and Krystof fails to show how they materially change the relevant data. Krystof blithely implies, but fails to show, that Hyatt made these errorsexplained that the employer's legitimate expectations of employee performance were wholly dependent upon an evaluative performance program alleged to be a pretext for age discrimination. Id. at 1243. Merging performance issues with pretext issues made sense to the Fisher court since, if the employer's job requirements were "found to be illegitimate, it follow[ed] that [the employer's] expectations were likely pretextual, and vice versa ... [T]o hold otherwise would unnecessarily insulate [the employer] from the burden of articulating a nondiscriminatory reason for the discharge of [the employees]." Id.
Krystof likens his case to Fisher because he asserts that "deficiencies in his performance" were the proffered reason for his termination.[6] In fact, Krystof's case is distinguishable from that case because Hyatt mentioned Krystof's performance only as it related to whether he


as General Cashier when Krystof was on vacation but Krystof had never performed the job of Food & Beverage Cashier Supervisor; (2) the Food & Beverage Cashier Supervisor job involved supervising 30-40 cashier, as well as scheduling and evaluating employees, and implementing the responsibilities as General Cashier; (3) Shaw's recent job performance was better than Krystof's, and Krystof had been experiencing performance problems in the job of General cashier, which [fact] led Barnish to conclude that Krystof could not handle the increased workload of the combined jobs.
Hyatt, 12(m) Statement, p. 8.
"An employee's self-serving statements about his ability, ... are insufficient to contradict an employer's negative assessment of that ability ... Such statements may create a material dispute about the employee's ability but do nothing to create a disputeIn that case, the employer's proffered reasons for discharging these employees were a reduction in force and the employees' poor performances. At the time of their terminations, however, the employees were informed only that they were being discharged as the result of economic cutbacks. Id. at 21-22.[9]
Krystof's case is distinguishable from Graefenhain for several reasons. First, unlike the employees in that case, who had been recognized for outstanding performance prior to their terminations, Krystof was criticized for his performance before his discharge. Id. at 15. Second, as explained above, Krystof's poor performance was not the proffered reason for his termination. Rather, it was only one factor in Hyatt's decision to select Shaw for the consolidated position. Lastly, in Graefenhain, there was sufficient evidence to show that the employer


ADEA. See, Fisher v. Transco Services-Milwaukee, Inc., 979 F.2d 1239, 1244 (7th Cir.1992); but see, Hazen Paper Co., ___ U.S. at ___-___, 113 S.Ct. at 1705-06 (Supreme Court is undecided whether disparate impact may be applied under the ADEA). In a disparate impact claim, "an employee must first show that an employer utilizes a particular employment practice that results in a disparate impact upon a protected class of workers." Id. at 1245. Accordingly, in Fisher, the employee argued that the employer's program, "while having facially neutral criteria, fell more harshly upon [the employer's] older employees." Id. Krystof, in contrast, does not argue that Hyatt had a "facially neutral" policy that affected older workers disproportionately. Instead, Krystof only raises a disparate treatment claim  that "he was targeted forthe Light Forces has brought much fresh positive luminous plasma into our Solar System and this positive plasma has excited the mesosphere around planet Earth later that day to produce some awesome noctilucent clouds:

The Light Forces have communicated that for the first time since 1996 Archon invasion, Ascension archangels are again present in our Solar System.

A few days later, rainbow cloudships began to appear in China.

In Xiamen on June 24th:

And in Guangzhou and Nanning on June 28th.

The Light Forces have communicated that the process towards the Event is now accelerated and there is no time to build physical Islands of Light before the Compression Breakthrough. If you feel guided to continue with Island of Light projects feel free to do so, but main focus now is to anchor