Activity and properties of alpha-L-fucosidase are dependent on the state of enterocytic differentiation of HT-29 colon cancer cells.
Previously we have demonstrated an impairment in the activity of alpha-L-fucosidase in colon tumours. In order to establish an in vitro model to study this enzyme in colon cancer, we have determined the activity and properties of the enzyme during the differentiation of HT-29 colon cancer cells. Cultures were committed to differentiate into enterocyte-like cells by placing them in a culture medium without glucose for 18-21 days. The state of differentiation was evaluated by assaying the activity of enterocytic marker enzymes, and the acquisition of enterocyte morphology was assessed by electron microscopy. The alpha-L-fucosidase activity was determined using a fluorometric method. Intracellular levels of alpha-L-fucosidase activity are lower in non-differentiated cellsA page as part 4th

A vision into dark mirror

CAN U SEE ME? ARE U NEAR ME? CAN U HEAR ME CRYING OUT FOR LIVE? CAN U TELL ME,WHERE'S THE GLORY OF LIGHT? RIDE THE DAYS & SAIL THE NIGHTS,,WHEN IT'S OVER,,YOU'LL FIND THE ANSWER RUNNING IN THE WHISPERING RAIN,CAN U WONDER?! DO U SEE A VISION OF A PERFECT PLACE?DOES IT MAKE U LAUGH,OR PUT A SMILE SINISH ON U FACE? DO U NEED A MIRROR,DO U SEE IT WELL? THERE ARE PEOPLE LAUGHING,THEY'RE ALL LAUGHING AT U..!? IF ONLY THEY COULD SEE WHAT U ARE SAYING IS TRUE,,DON'T THEY KNOW? THEY HAD NO ANSWERED,,'I'LL SEE U..'


was analyzed at a single timepoint in each species (7 h) chosen to coincide with maximal induction of transcripts encoding inflammatory cytokines in human monocyte-derived macrophages ([@B3]).

Macrophage immunometabolism is a burgeoning field based upon the view that metabolic requirements change with functional polarization ([@B40]; [@B16]; [@B107]). Published studies have focused on regulation of the tricarboxylic acid (TCA) cycle and accumulation of intermediates such as itaconate, succinate, and ketoglutarate as signaling molecules ([@B107]). Like the NOS2 pathway, much of the evidence for roles of metabolic intermediates and enzymes in macrophage activation/polarization derives from *in vitro* studies of inbred mice, and at least some of the effects of LPS on mitochondrial function are mediated by endogenous NO ([@B122]). Itaconate, produced through the induction of the enzyme ACOD1, which diverts citratecontrol and LPS-stimulated BMDM from additional species were downloaded from the European Nucleotide Archive (ENA). Details of all of the accessions are provided in [Supplementary Table S1.](#TS1){ref-type="supplementary-material"} This comparative dataset comprises eight additional species: buffalo, goat, cow, horse, mouse (both *Mus musculus* and its outbred relative, *Mus spretus*), pig and rat, as well as the sheep. For all species except mouse, the agonist used was *Salmonella minnesota* Re595 LPS, which is a pure TLR4 agonist ([@B133]). In the case of the two mouse species, the agonist used was KLA (Kdo2-lipid A) the active core of LPS ([@B74]) and samples were obtained after 6 h.

While publicly sourced RNA-seq libraries can differ both in preparation and sequencing methods, it is possible to process their data with a common normalization, producing


lactate ([@B23]). *OXCT*, encoding succinyl CoA:3-oxoacid CoA transferase, which catalyzes the first step in ketolysis, was also expressed constitutively.

Expression of Non-coding RNA in Sheep Macrophages {#S3.SS3}
-------------------------------------------------

Genome-wide studies in multiple species have indicated that mammalian genomes are pervasively transcribed. Aside from protein-coding genes, several novel classes of non-coding RNAs (ncRNAs) contribute to transcriptional and translational regulation. Several thousand unique microRNAs have been identified in ruminant species ([@B7]). These have not been captured in our pipeline unless we captured their precursors. Another class of non-coding RNAs is derived from the transcriptional activation of enhancers; these were identified in LPS-stimulated mouse macrophages ([@B59]) and were also identified in genome-scale 5′RACE (CAGE) in human monocyte-derived macrophages responding to LPS ([@B3]). These transcripts are rapidly degraded from the 3′ end by the exosometranscripts for which there is some evidence of innate immune function in rodents, and which were up-regulated in all the mammalian macrophages. They include many additional examples of inducible feedback regulators highlighted in analysis of the sheep time course. In [Table 2](#S4.T2){ref-type="table"}, we identify examples of transcripts that were expressed and/or regulated in macrophages and clearly highly divergent between rodents and large animals. Some families of genes are discussed in more detail below.

######

Summary of novel genes induced by LPS in all mammalian BMDM.

  Gene symbol   Gene name/description                                  Gene function


the London eye. However, if you are an avid art fan, then I’m sure many of you will agree that the National Gallery is easily one of the best go-to’s for a fabulous exhibition, or just a leisurely artistic browse! As well as being home to some of the most renowned paintings in the world, their ‘Be Inspired’ collection is simply amazing – especially for those with wild imaginations (like myself) who love making up stories about the portraits!

2. For great food…
Having been countless times and never had a bad meal, Zuma is easily my favourite place to eat in London. From the amazing quality of food and delicious cocktails, to the spacious layout and grand round tables, Zuma combines everything you need for a blissful evening withThe synthesis of molecular composites, that is composites formed from molecules comprised of stiff or rigid molecular segments, interspersed with flexible segments, has attracted considerable attention in the recent past. In this regard, the reinforcing fibers contained in ordinary composites suffer from the fact that they have a tendency to separate from the material in which they are incorporated, thereby impairing the composites' physical properties. In addition, a substantially homogeneous dispersion of fibers in a composite matrix is frequently difficult to achieve. Partly as a consequence of the foregoing, therefore, there have been many attempts to develop so-called "molecular composites," using techniques designed to overcome the disadvantages described.
Unfortunately, however, molecular composites as they are presently understood might be more accurately described as an objective desirable to achieve, rather


Veitch Penny Solicitors

A catastrophically injured road accident victim who was mistakenly advised to settle her damages claim for just £12,500 could now be in line for more than £2 million after the Supreme Court ruled in a landmark case that she lacked the mental capacity to sign up to the compromise, which therefore had no legal effect.

The woman had been struck by a motorbike as long ago as June 1999. She had issued a claim against the motorcyclist’s insurers, seeking a maximum of £50,000 damages, and had eventually settled her claim for £12,500. It subsequently emerged that she was much more gravely injured than had been thought and that the compromise represented a gross undervaluation of her claim.

Her legal team argued that the woman had lacked the mentalQ:

Database running out of space

My database has 16MB of space left.
I used to just truncate as I was taught but I found these links that advise against truncating:
http://www.sqlskills.com/blogs/paul/why-you-should-not-shrink-your-data-files/
http://blog.sqlauthority.com/2011/01/19/sql-server-shrinking-database-is-bad-increases-fragmentation-reduces-performance/
Is there anything else I can do on my database to reduce the size other than deleting table records? I am new to the DBA forum and I probably should have looked around for other questions before posting but I am desperate as I am worried about my database going down.

A:

If your database has 16 MB of free space, and the drive it's on has plenty of free space, then don't worry about it. As long as there is sufficient space and you haven't disabled the database's ability to autogrow, then the database will grow the data file when it needs


or your MP3 collection, or videos from your last vacation.

A:

You are lost on autogrow, you are lost on filegroups. For your own sake, I hope this is not a production DB.
Having said that - here is how the DB spacing works:
Execute this in SQL Server Management Studio
sp_helpdb <yourdbname>

This should give you 2 sets of output.The first has a column called db_size, which will give you the current DB size. The second will give you independent sizes of you data and log files. Check the column here called maxsize.
Now execute this:
USE <yourDB>
GO

EXECUTE sp_spaceused
GO

The output of this query will tell you the unallocated space, or free space available in your DB file. When this fills up, your DB will either grow or will stop, based on various settings andOpportunities to train amphibious crews in launching, maneuvering, landing, and recovery are limited by ship availability, lengthy requisition process, crew distribution, travel requirements, weather conditions, and political climate, as well as by budgetary, time, and other personnel constraints. Yet it is imperative that crews receive adequate training before engaging in such inherently hazardous operations, possibly subjected simultaneously to heavy weather, enemy fire, or unexpected equipment malfunction.
Simulators have proved their worth in regard to air, land, sea, and undersea activities, but heretofore amphibious operations have not received comparable attention or achieved appreciable success, probably owing in large part to the diversity of demands made upon amphibious personnel and their equipment in actual operations. The variety of requirements necessitates a diversified approach to such training and to the conditions to


Fly-Fishing Western Trout Streams Book

Details

Learn to read and understand western water and what to expect in each season on different types of streams

How to select the best, most effective patterns for western trout

Western hatch chart
Author Jim McLennan takes readers out on the water to show in detail how best to fish trout streams in the West from Canada to Mexico. The lessons come directly from McLennan's experiences on the water. Covers tactics for dry fly fishing as well as fishing from a drift boat.
About the Author:
Jim McLennan's previous two books are Blue Ribbon Bow and Trout Streams of Alberta, and he has hosted a fly-fishing TV show called Iron Blue Fly Fishing. He lives in Alberta, Canada.
160 pageslow expression. Every column represents a tissue sample and every row represents an lncRNA/mRNA probe. C represents cancer tissues and N represents adjacent normal tissues. (A) lncRNA hierarchical clustering. (B) mRNA hierarchical clustering.](pone.0169232.g001){#pone.0169232.g001}

mRNA functional annotation and pathway analysis {#sec015}
-----------------------------------------------

In order to understand the biological processes, we performed Gene Ontology (GO) and pathway analysis. GO analysis revealed aberrantly expressed mRNAs involved in up-regulated GO function, including matrix organization, mitotic cell cycle, cell adhesion, cell disassembly, and collagen catabolic process ([Fig 2A](#pone.0169232.g002){ref-type="fig"}). Down-regulated GO functions included small molecule metabolic process, oxidation-reduction, O-glycan processing, transmembrane transport, and DNA dependent transcription ([Fig 2B](#pone.0169232.g002){ref-type="fig"}). Pathway analysis revealed aberrantly expressed mRNAs involved in up-regulated pathways, including cell cycle, focal adhesion, ECM-receptor interaction, pathways in cancer, and PI3K-Akt signaling ([Fig 2C](#pone.0169232.g002){ref-type="fig"}), whereas down-regulated pathways included


indicates up-regulation and blue indicates down-regulation relative to adjacent non-neoplastic tissues. The lines between nodes indicate a correlative relationship within the group, solid line represents positive correlation, and the dotted line represents negative correlation. (A) LncRNA-mRNA expression correlation network of core mRNAs in cancer tissues. (B) LncRNA-mRNA expression correlation network of core mRNAs in adjacent non-neoplastic tissues.](pone.0169232.g005){#pone.0169232.g005}

10.1371/journal.pone.0169232.t004

###### The correlation between lncRNAs and the four core mRNAs.

![](pone.0169232.t004){#pone.0169232.t004g}

  mRNA     LncRNA      Pearson correlation
  -------- ----------- ---------------------
  PIK3R1   NR_003949   0.9535264
  ITGB1    NR_027340   0.9681052
  HIF1A    MIR31HG     0.9315686
  DDIT4    SOX2-OT     -0.9386784

QRT-PCR validation {#sec019}
------------------

To further validate thecycle arrest \[[@pone.0169232.ref025]\]. LncRNA APOC1P1-3 inhibits apoptosis by decreasing α-tubulin acetylation in breast cancer \[[@pone.0169232.ref026]\]. LncRNA H19 promoted LSCC progression via miR-148a-3p and DNMT1 \[[@pone.0169232.ref027]\]. Our results demonstrate that 1459 differentially expressed lncRNAs and 2381 differentially expressed mRNAs were identified by microarray in advanced LSCC and may act as novel biomarkers for this disease. Among them, lncRNAs MIR31HG, NR_027340, SOX2-OT and their correlated mRNAs HIF1A, ITGB1, DDIT4 were selected with core function by bioinformatics analysis and further validated their expression by qRT-PCR in advanced LSCC.

In this study, mRNAs functional annotation and pathway analysis revealed that the aberrantly expressed genes were involved in biological processes, such as matrix organization, cell cycle, adhesion, and metabolic pathways. Previous studies have already indicated that these are all classical biological processes in cancer.


The nodes connect by an edge. The indicators a, b, c, p, u, m, inh, ex, dep, ind are abbreviation of activation, binding, compound, phosphorylation, ubiquitination, missing interaction, inhibition, expression, dephosphorylation, indirect effect respectively.

(PDF)

######

Click here for additional data file.

###### LncRNA-mRNA expression correlation network in cancer tissues.

(PNG)

######

Click here for additional data file.

###### LncRNA-mRNA expression correlation network in adjacent non-neoplastic tissues.

(PNG)

######

Click here for additional data file.

We are sincerely grateful to the CNKINGBIO for the help of doing bioinformatics analysis. We also acknowledge the editorial assistance provided by FEB.

[^1]: **Competing Interests:**The authors have declared that no competing interests exist.

[^2]: **Conceptualization:** JF.**Data curation:** HL.**Formal analysis:** LF RW.**Funding acquisition:** JF.**Investigation:** LF RW ML.**Project administration:** LF RW.**Resources:** HM NH.**Supervision:** JF.**Writing -- original draft:** LF RW HW.
Q:

How to calculate the difference between two dates using PHP?

I have two dates of the form:
Start Date: 2007-03-24
End Date: 2009-06-26

Now I need to find the difference between these two in the following form:
2 years, 3 months and 2 days

How can I do this in PHP?

A:

I suggest to use DateTime and DateInterval objects.
$date1 = new DateTime("2007-03-24");
$date2 = new DateTime("2009-06-26");
$interval = $date1->diff($date2);
echo "difference " . $interval->y . " years, " . $interval->m." months, ".$interval->d." days ";

// shows the total amount of days (not divided into years, months and days like above)
echo "difference " . $interval->days . " days ";

read more php DateTime::diff manual
From the manual:

As of PHP 5.2.2, DateTime objects can be compared using comparison operators.

$date1 = new DateTime("now");
$date2 = new DateTime("tomorrow");

var_dump($date1 == $date2); // bool(false)
var_dump($date1 <


* @return string Formatted interval string.
 */
function format_interval(DateInterval $interval) {
    $result = "";
    if ($interval->y) { $result .= $interval->format("%y years "); }
    if ($interval->m) { $result .= $interval->format("%m months "); }
    if ($interval->d) { $result .= $interval->format("%d days "); }
    if ($interval->h) { $result .= $interval->format("%h hours "); }
    if ($interval->i) { $result .= $interval->format("%i minutes "); }
    if ($interval->s) { $result .= $interval->format("%s seconds "); }

    return $result;
}

All that's left now is to call our function on the $difference DateInterval object:
echo format_interval($difference);

And we get the correct result:

20 days 6 hours 56 minutes 30 seconds

The complete code used to achieve the goal:
/**
 * Formatsqrt(500))) + -3)**2.
-5400027 + 10800*sqrt(5)
Simplify ((1 + -3*sqrt(1573) + 5)*2)**2.
-1584*sqrt(13


Infosys, Wipro and HCL Tech. The drop was largely more of a sentimental impact

PSU Banking stocks continued to have a good day in trade with stocks like Union Bank and Syndicate Bank among the gainers.

Shares in Apetch rose after the company formed a strategic alliance with Montana International School for preschool education. The stock was locked at the upper end of the circuit filter in trade.

Technofab Engineering on the other hand jumped 22 per cent after the company bagged 2 order from Power Grid worth Rs 227 crores.

Meanwhile, European markets were absolutely flat, awaiting cues from the European Central Bank.“How much profit were you making with Adwords?”

ecommerce business owner: “Well…” <silence> <scratching top of their head>

The real reason behind “Adwords is too expensive” is that ecommerce store owners are not 100% sure if they are profitable…

I would be anxious to drop $5k a month too if I didn’t know I would get it back.

Adwords (or PPC) is not “expensive” if you know it is profitable

If you knew exactly that for every 1 dollar spent you’ll get 8 dollars in revenue and 3.5 dollars profit (which is 350% actual ROI), it would be a no-brainer to use PPC.

But with many different operational expenses, shipping, promotions and taxes – it’s hard to determine if it’s profitable or not…

That’s what’s great about PPC. It goes hand in hand with Google


Analytics, allowing you to track all sales and trace them back to separate channels.

Solution: Learn exactly how much profit you make from ads

You can use Google Analytics custom reports that will trace back each sale to it’s marketing channel and calculate profit with extreme precision.

2) Myth: I don’t want to spend so much on advertising every month

I had one client calling me every month asking if we could lower our agency fee for him.

When he sees a $900 invoice in his inbox from our agency fee and extra $4,000 receipt each month for Google ads, he gets anxious. He was spending $4,900 a month = almost $60k every year on PPC marketing.

But…

For each dollar spent you make extra profit while building your customer base!

I decided to walk himQ:

Prove that: $\cos(x) -1 < -\frac{x^2}{2} + \frac{x^4}{24}$

Prove that:
$$\cos(x) -1 < -\frac{x^2}{2} + \frac{x^4}{24}$$ for $x \ne 0$

I need to prove this using Cauchy's mean value theorem.
What I did:
$f(x) = \cos(x) -1$
$$g(x) = -\frac{x^2}{2} + \frac{x^4}{24}$$
If I can show that:
$\frac{f(x)}{g(x)}\lt 1$ that would prove the original inequality
so,
$$\frac{f(x)}{g(x)} = \frac{f(x) - f(0)}{g(x) - g(0)} = \frac{f'(c)}{g'(c)}$$ for $0\lt c \lt x$
$$\dfrac{f'(c)}{g'(c)} = \dfrac{-\sin(c)}{-c + \frac{c^3}{6}}$$
My problem is the following expression is not always less then 1! (for example $c=2.4$)
What am I doing wrong?

A:

I think it will be easier to show that: $$ \cos x - 1 + \frac{x^2}2 < \frac{x^4}{24} $$
Define $f(x) = \cos x - 1 + \frac{x^2}2$, $g(x) = \frac{x^4}{24}$.
Now using the Cauchy MVT: $$ \frac{f(x)-f(0)}{g(x)-g(0)} = \frac{6(c-\sin c)}{c^3} $$
Now just show that $ h(x) = \frac{6(x-\sin


Haemoglobin inhibits the development of infective promastigotes and chitinase secretion in Leishmania major cultures.
Haemoglobin or blood in the growth medium of Leishmania major inhibited the formation of infective promastigotes and the secretion of chitinases. Inoculation of mice with stationary-phase parasites from control medium caused infections in 20/29 mice, compared to 3/20 mice injected with parasites grown with 10% rabbit blood, or 1/30 mice that received parasites grown with rabbit haemoglobin. The concentration of peanut lectin (PNA) required to agglutinate promastigotes was used as an index of their infectivity, ranging from a high concentration for infective populations to a low concentration for relatively non-infective populations. Agglutination of 50% of the parasites from control medium or from medium containing rabbit haemoglobin required 4.1 micrograms PNA/ml and 0.1 microgram PNA/ml, respectively.Jun 20, 2015

1. Semuc Champey, Guatemala

This natural limestone cascade drops gently down the mountainside to create a series of falls and clear turquoise pools.

2. Viñales Valley, Cuba

This amazing valley and its surrounding limestone monuments seem like a picture out of Southeast Asia rather than the island of Cuba.

3. Mount Roraima, Venezuela

Venezuela’s highest tabletop mountain, with its pyramid-like steps and cascading waterfalls, is so high that it’s perpetually ringed by masses of swirling clouds.

4. Palais Ideal du Facteur Cheval, France

Created by a local mailman over the course of several decades, this folly almost looks like something straight out of Tomb Raider.

5. Chapelle St-Michel d’Aiguilhe, France

Towering high over the surrounding town of Le-Puy-en-Velay, this stunning chapel dates back over 2,000 years.

6. Ruins of Leptis Magna, Libya

These sprawling ruins, with their


to this choice by providing a tree $t\in L$ of size at least $p$. In the third turn, [adversary]{} must choose a decomposition of $t$ into fragments $c'\cdot c\cdot t'$ such that $|c|\geq 1$ and $|c\cdot t'|\leq p$. In the fourth and final turn, we must provide a number $n\in{\mathbb{N}}$ such that $c'\cdot c^n\cdot t'\notin L$. If we are able to do so, we win the game; otherwise, [adversary]{} wins. We can prove that $L$ is non-regular, if we have a winning strategy for the game.

Consider the language $L_1 = {{\{\,f(g^n\cdot a,g^n\cdot a)\midn\geq 1\,\}}}$, shown schematically in Figure \[fig:PumpingLemmaExample1\]. Using Lemma \[lem:PumpingLemma\], it is easy to show that this language is non-regular: we always win by presenting [adversary]{} with the tree $t = f(g^p\cdot a,g^p\cdot a)$. To see this, notice that in whateverthat as the number of transfers increased during a patient's hospital stay, the patient would be less likely to rate how often nurses treated them with courtesy and respect as *always*. Results showed that the odds of an *always* rating was 25% lower if a patient transferred 3 times or more; however, these results were marginally statistically significant (*P* \< .10).

Hypothesis 7 stated that as the number of transfers increased during a patient's hospital stay, the patient would be less likely to rate after they pressed the call button, how often they got help as soon as they wanted it as *always*. The results revealed that the odds of an *always* was 27% lower if a patient transferred 3 times or more (*P* \< .01).

Hypothesis 8 stated that


4 to 6.

Environment: Quiet at Night and Cleanliness Hypotheses (H9 to H10) {#section10-2374373519836467}
------------------------------------------------------------------

Hypothesis 9 stated that as the number of transfers increased during a patient's hospital stay, the patient would be less likely to rate how often the area around his or her room was quiet at night as *always*. Results showed that the odds of an *always* was 36% lower if a patient transferred 3 times or more (*P* \< .001).

Hypothesis 10 stated that as the number of transfers increased during a patient's hospital stay, the patient would be less likely to rate how often his or her room and bathroom was kept clean as *always*. The results revealed that the odds of an *always* was 1.3 times greater if a patient transferred once (*P* \< .001).is president of Innovative Healthcare Solutions, LLC. She has held leadership roles across the continuum of care and has extensive experience with process improvements in the patient flow and resource allocation.

**Nancy Borkowski**, DBA, CPA, FACHE, FHFMA is a professor in the Department of Health Services Administration at the University of Alabama at Birmingham and the UAB Site Co-Director, NSF I/UCRC Center for Health Organization Transformation.

**Stephen J O'Connor**, Ph.D., FACHE, is a professor in the Department of Health Services Administration at the University of Alabama at Birmingham and a Scholar in the UAB Lister Hill Center for Health Policy.

**Patricia A Patrician**, PhD, RN, FAAN is professor and the Rachel Z. Booth Endowed Chair in Nursing at the University of Alabama at Birmingham.

**Robert Weech-Maldonado**, MBA, PhD, is a professor in


to be
	 * passed to the "setDetachedAttributes" function in the same order.
	 *
	 * @return {array}
	 */
	getDetachedNodes()
	{
		return [this._labelContainer[0], this.span[0]];
	}

	/**
	 * Sets the given associative attribute->value array and applies the
	 * attributes to the given DOM-Node.
	 *
	 * @param _nodes is an array of nodes which have to be in the same order as
	 *      the nodes returned by "getDetachedNodes"
	 * @param _values is an associative array which contains a subset of attributes
	 *      returned by the "getDetachedAttributes" function and sets them to the
	 *      given values.
	 */
	setDetachedAttributes(_nodes, _values)
	{
		this._labelContainer = jQuery(_nodes[0]);
		this.span = jQuery(_nodes[1]);

		this.set_value(_values["value"]);
		if(_values["label"])
		{
			this.set_label(_values["label"]);
		}
		if(_values["class"])
		{
			this.span.addClass(_values["class"]);
		}
	}
}
et2_register_widget(et2_date_ro, ["date_ro", "date-time_ro", "date-since", "date-time_today", "time_or_date", "date-timeonly_ro"]);

/**
 * Widget for selecting a date range
 */
export class et2_date_range extends et2_inputWidget
{
	static readonly _attributes: anya wide range of species and substances, with particular attention to cues originating from larval food, immature stages, predators, and to synthetic compounds. We note that the effect of many substances differs between species, and that many substances have been tested in few species only, revealing that the information is scattered across species, substances, and experimental conditions.


originate from a company, not from traders. Second, warrants are dilutive to the underlying stock. When the holder exercises a warrant, the company issues new stock, rather than delivering existing stock. Finally, they can be attached to other securities, most notably bonds, giving the holder the right to purchase shares of stock, as well.

While warrants come in both put and call varieties, for use in warrant coverage they typically are the latter.

For example, an investor purchases 1,000,000 shares of stock at a price of $5 per share, totaling a $5,000,000 investment. The company grants a 20% warrant coverage, and issues to the investor $1,000,000 in warrants. In technical terms, the company guarantees 200,000 additional shares at an exercise price of $5 per share.

Issuing warrants do not give thesatisfactory rate or amount, warrants attached to a bond can make them more attractive to investors. Often warrants are seen as speculative.

One of the best examples of warrant coverage took place during the financial crisis of 2008. Wall Street giant, Goldman Sachs, needed to increase capital and raise the perception of its financial health. Goldman sold $5 billion of preferred stock to Warren Buffett's Berkshire Hathaway, Inc. The warrants to purchase $5 billion of common stock with a strike price of $115 per share had a five-year maturity. Goldman's shares were trading near $129 at that time, giving Berkshire an instant, although not guaranteed, profit.


issue of whether the District Court erred in granting summary judgment based on the running of the statute of limitations.
Appellants initially contend that the statute of limitations was tolled because respondents were outside the State of Montana during periods of time after the date of the accident. This contention is based on section 27-2-402, MCA. Respondents, on the other hand, argue that although they have been nonresidents and outside Montana at certain times subsequent to the date of the accident, they have always been available for service of process under Rule 4D(3), M.R.Civ.P. (Montana's long-arm statute).
In Montana a tort action must be commenced within three years of the commission of the tort. Section 27-2-204, MCA. Section 27-2-402, MCA, provides:
"If when the cause of action accrues against a personI take it out and pry a wedge of stone from the wall to resume my work. Grasping the blunter end and covering my fingers with the twill of my coat, I watch as chips of stone flick up from the blade.

A sparrow is singing. Its cheery trill echoes through the chamber, but I cannot see it. The gray walls outside conceal its plump body. Perhaps it is secreted behind a turret or piling twigs into a crack in the masonry. The pungent odor of the guano that concretes the window mingles with the stench of my sweat from countless nightmares.

Yes, even I have fears.

I scan again, craning my neck through the grate, sliding it with a metallic rattle, but it is the same: slow-growing green lichen mottling


"If only you would let me out." I rattle the bars.

She turns, too quickly, as if she has tarried too long. The white swan of her neck stretches eagerly toward the door out of the tower.

_How beautiful it is_ , I think. _How beautiful that slim, graceful neck would be to them_. A small silver cross glistens at the hollow of her throat.

At the top of the stairs, she pauses. Head cocked, she looks at me with eyes bluer than lapis, and her lips move again in a silent prayer. There is something wistful in her eyes, sad even. In that moment, she reminds me of Sabine.
CHAPTER TWO

Sabine. How I miss her. I wonder where she is now. Probably perched on a turret or sitting stone-like somewhere, waiting.humans. Not for company. The life of an immortal is lonely, but it is not for that. They do so to defeat us by number alone. To win."

Her gaze bored through me. "Where, then, did the Cruxim come from? Why are you here? Why are there not more of you?"

"I do not know. I am no conduit for my Maker. I do not even know him," I admitted. "I know only my purpose. I feel the need to hunt them, to feed off them. An insatiable thirst to kill." I shifted on the doorstep, feeling the warmth radiated by her fur. "How are you here?"

"I know neither." Her voice was proud, hard. "Nor do I care to. I am here. Perhaps I always have been. One day, I


and then reread, and then kept with the others in a bundle by my bedside.

I was lonely, if you suppose; but it was more than that. Joslyn's tenderness softened the edges of a world that had grown cruel to me. The undead were everywhere. As fast as I killed one, as quickly as its blood quenched my hatred, another would take its place. They were organized by then, too, forming tight-knit covens and rarely venturing out alone. Although I had no shortage of prey, catching my quarry proved increasingly difficult.

The year she turned eighteen, Joslyn had written me that the convent had been attacked by brigands. One of the sisters, a girl named Sister Ermilita, had been killed in a field near the castle. Her body, when found,up at me briefly and then quickly back down at the gift. Opening the heavy cover, Joslyn had stroked a slender finger across the hand-illustrated page, over the face of a Seraph that graced it. I remember how her long lashes cast crescents of shadow on the paper. She smiled up at me, but her eyes held a question.

I looked away quickly, afraid, myself, of the answer.

Although she never mentioned my place within the pantheon of angels and monsters, Joslyn had always been fascinated by mythology. Why I indulged her in it I do not know. In my own way, maybe I was bringing her closer to my true self, hoping—and yet simultaneously fearing—that one day she may really know me.

"And this," I said, holding out a bespeckled


day! The wolfman who tears men apart! The gigantor, able to lift a horse with a single hand. Roll up. Roll up!"

"Gandler just got two more acts," agreed his brother. "I wonder what he'll call you two?"

"The fallen angel? The whore of the pride?" Sinbad suggested.

I flew at the cage, my intensity forcing the single torso to shuffle back from the bars. "You might consider minding your manners," I snarled.

"Might," Sinbad said. "Except it looks like Gandler's got himself some pussy." The two of them broke into manic laughter.

"Ignore them. Pair of stupid Irishmen. Two heads and they couldn't rustle up half a goddamn brain between them," another voice interrupted from a wagon opposite.

"Catwoman meet wolfman," Seamus heckled.

"Shut your mouth, idiot," came the man's response. "We're in company.stop Karl. But you two ... it doesn't take a genius to recognize you're different. Stronger. Supernatural."

I did not know how to respond to that. Could this hairy stranger be trusted? Could any of them? It was too soon to tell.

"I saw her, you know. They took out her teeth. Removed her claws. And yet, here she is again. Unchanged. Leonine. Feminine. And wholly unnatural. And you? If they pluck out those feathers, what will happen?"

I stared straight ahead, watching the jostling rump of the pony in front of me. "I will not be able to fly."

The wolfman's eyebrows quirked up. "So it is true then?"

"Yes."

"Then Gandler's Circus has both angel and devil, and who shall win the battle for our poor mortal souls?"

"No abomination shall triumph over


told his master what he had overheard? Just as I thought it, Sabine reappeared, and our wagons passed through the gates and on to the grassed lawn inside the ramparts.

Each wagon had been assigned a teamster. Mine was just a boy. Lee, his name was. Sabine's was the other boy with the face full of scars.

"Has the circus come to Provins before?" I asked over the clop of the pony's feet as the boy led the wagon through the gates. He ignored me and spat on the cobblestones.

Inside, a flood of people had filled the streets, some carrying produce or other goods for market, some even herding geese or pigs. Around us, the air had been fetid with a thousand scents: cinnamon and spices, flowers, the tang ofDanette nodded. "But not if you are in here. And not if he has Sabine. You would not risk it. You love her."

She was right: I would not. And yet rage filled me brimful at the thought of one more of them, and one so evil as Dr. Gandler.

The night was broken by a scream. High-pitched and ringing, it echoed off the iron bars of the wagon and fled into the night.

Her huge sapphire eyes read the terror in mine. "Why do you think I wanted to come to you, Amedeo?"

"To warn me."

"Yes, there was that, but more than that. I came to you to die. I wanted you to feed on me. This earth is hell to me now. I can bear it no longer, and you


jolted awake in the mid-afternoon, drenched and listless, the silver cross fastened around my neck.

"Heard you played your part well, Feathers," Sinbad called to me. "Best takings ever last night. But t'is morning, quite the kerfuffle, I hear. Seems that cat of yours escaped. Treacherous she-bitch. I'm surprised Gandler hasn't come to torture you over it yet."

"Heard Feathers was otherwise occupied last night, Sinbad," Seamus joined in. "What'd you do with that pretty little Vampire in the darkness? You might act like a gentleman in public, Feathers, but from what I heard you weren't no angel last night."

Sinbad laughed uproariously. "Wonder what old man Gandler would think of that atrocity. Or is that how you came about, Feathers? Mammy was an angel, Pappy was a devil? I betprowling the city together."

I nodded. "This woman who weeps blood. What is her name?"

"Joslyn, he calls her." Trudie found half a moldy cake and stuffed it in her maw, then she continued, "But I call her bluff. She's beautiful, sure, but she has the unnatural look of that poor dead girl about her. I never see her by day. There's something not right about her. I hear tell she approached him too." Trudie swallowed down the lump of cake and followed it with half an apple. "I never heard of a woman who weighed less than three hundred pounds or weren't tattooed like a sailor wanting to join the circus."

"Joslyn," I repeated quietly to myself.

_It cannot be her_ , I told myself. _How would she know I was


has devoted his life to it. He knows! You must fly. Now, Joslyn. Do not delay. You are in danger." I could have cursed Sabine for not telling her.

"No, Ame. It is you who is in danger, but I have come for you. We will be together."

Her voice had a singsong quality that made her delusion even more apparent.

"Joslyn"—I put a hand up to the silver cross—"the girl who once wore this, he found in the village. She was my jailer ... until Beltran. Please..." I felt my throat constrict with anxiety for her, even after all these years apart. "Please. Leave this place. Leave me."

She shook her head, and her curls bounced wildly. "Never, Ame. I love you."

I had forgotten how stubborn she could be, and hownot an impatient creature." He scratched his head and wiped at another smear of blood on his bandage. "I told Theron nothing. Never did trust the man myself. But then again, I'm not a dog person." Kettle laughed and then pulled himself together.

"Sabine must have given him a signal."

"Yes. But it's you I need, Feathers. You or someone like you. Someone to match Karl's strength. Gandler has Karl with him day and night."

"Kettle, I cannot."

"What? Not even with a belly full of that poor girl's blood? Not even with Joslyn's help?"

An icy chill ran down my spine. "How did she come to be here? She should not be here." It was all I could do to keep my voice at a whisper.

"Don't scowl at me. She was Sabine's


only excitements.

Still Joslyn did not look at me. She strode to the butcher's block and carefully took up something off it. Squinting into the light, she inspected what appeared to be a hollow glass tube. A syringe, I identified. "Soon this will be all be over, Ame." Her tone was gentle. "Do you remember, my angel, that night in the ruined castle?"

She turned to the side, the arm holding the implement obscured, and finally glanced over at me. Was it wistfulness or the sting of wounded pride that I detected in her profile?

"How could I forget the worst day of my life?" I spat.

Her beautiful face twisted for an instant. Then her expression calmed and her eyes became cold blue jewels in the steely helm of her face.strength of her paw held me down and felt as real as if she were there herself. I felt her lips brush my ear and then my neck, and the feeling soothed my semi-lucid mind.

_Sabine, I have tried to find you_ , I heard the dreaming voice in my head tell her, panicked. _Where are you? Where is your stone?_

Something told me my fear was that death had found her and that his black wings had carried her here, through the night, to my dreaming form.

"Hush," she said, a word as tender as any I had ever heard from her, and I felt her body fold down next to me, warm and animate, and as real as if we were curled up together. I tried to reach out


thought. _You will have your fill of them in hell_.

"I will not let you go in there, will not let you go to him defenseless. You heard him. What if his words were true? If he does not want you, you might be walking to a death sentence. Then what would I have? I would have lost you both. No. It is unworkable."

"Ame." She put her hand on my arm, but I shrugged her off. "You still do not trust me?"

I looked away, at the slow-lapping water of the Breton Strait.

"If I should do this, then we can fight them together: you, me, and Sabine. There are hundreds of them, Gandler and Beltran besides. How do you hope to free her alone? You would be flying to yourdeath."

"And yet you would gladly hurry towards yours? No. I cannot let you."

Joslyn sat in the sand and drew her legs up to her chest. "Without you, I would gladly rush to death. I have begged you for it. If you leave me here, I will go to them anyway. I will try to fight for you, and they will imprison me and leave me to burn most horribly at daybreak. They may well make you watch. Then you will have lost everything. Sabine, me, your life. Gandler knows your secrets now, remember."

"Thanks to you." I did not tell her that I was unsure whether such an injection would even work. Perhaps a Cruxim had to kill a mortal to die that way. I felt frustration mounting in


on the other side. It had gone better than I had hoped. Now to find a place to conceal myself before the sentries began to make their rounds. I approached the nearest building and found a chink in the edifice to pull myself up the stone. _Quickly, quickly_ , I cautioned myself. The roof was no good. Despite the old sayings, bats have good eyesight. No, somewhere inside, or by a window ledge, or perhaps even behind drapery would be better, or an alcove where I could conceal myself for a time in a place that was infrequently used.

I continued to pull myself up the wall until I came to a section where the flintstone grew rougher, and I spied a window ledge above. The window was shuttered,room, I pushed her down on the bed and bound her hands with the thick cord from the drapery. One arm subduing her, I leaned over her until my lips were close to her neck and whispered, "Now, tell me what happened to Joslyn?"

I knew what covens were like. I had watched so many over the years. The intrigues. The gossip. The scandals. Every Vampire on this island would be aware of Joslyn's return.

"Beltran ..." she began, choking the words out. Her bosoms heaved under her embroidered corset. A deadly beauty, she might have intoxicated any man but me. "She returned," the woman said. "Joslyn, Beltran's lover."

I must have flinched openly because her eyes widened and she looked momentarily amused. "You did not know they were lovers?"

I glanced


inconspicuous in a street full of women who were anything but demure. "Make sure you find a big one. I wouldn't mind swapping this corset," I whispered. "And don't try to go anywhere. I am right here, watching."

The thought seemed to amuse her. Then she turned and walked up the street a distance to where a solidly built older woman had hitched her red skirt up to the thigh.

"Come on, lad," she coaxed. "Ol' Mathilde gives a discount to young boys. Let a real woman show you how it's done."

I saw Evedra nod and fumble in the pocket of her trousers as she stepped forward and took Mathilde's hand. Turning, she led the woman back down the street toward me.

Guilt and revulsion assailed me when I saw howJoslyn to the fires of hell. And I felt more alone than I ever had.

You are never alone.

When I finally looked up, it was at the slim legs of someone standing over me.

The skin was pale and smooth as white marble, and for a moment, I cursed. I cannot deal with another of them right now. I stayed as I was, facedown on the sand, until I felt a gentle hand stroke my wings.

My wings!

Immediately, I spun over, flipping onto my back to conceal them. The sun shone through the silver hair of the woman who stood over me and illuminated the argent tips of her own wings. I put a hand up to my eyes to see her better.

Her eyes were as pale and shining as a


the selection to the specified selection in |selection|.
  // If there is composition text, it will be confirmed, which will update the
  // selection range, and it overrides the selection_start to which the
  // selection will move to.
  bool MoveCursorTo(const gfx::SelectionModel& selection);

  // Helper function to call MoveCursorTo on the TextfieldModel.
  bool MoveCursorTo(const gfx::Point& point, bool select);

  // Selection related method

  // Returns the selected text.
  base::string16 GetSelectedText() const;

  // The current composition text will be confirmed. The selection starts with
  // the range's start position, and ends with the range's end position,
  // therefore the cursor position becomes the end position.
  void SelectRange(const gfx::Range& range);

  // The current composition text will be confirmed.
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It's fun to drive around various beaches of Goa || Must do things in Goa, India

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Hiring a bike, car or jeep is one of the most important thing for exploring goa in best way and make best of your trip to this beautiful destination, which is popular for it's beaches. Goa beaches are very well connected through roads and best way to commute is through personal vehicles which can rented for as many days as you want. This Photo Journey shares some information about Car/Bike renting in Goa and some photographs from Goa which were clicked while driving across the city.

Before going to Goa, we reached to few of the folks who rent vehicles in Candolim area. Actually we planned to stay around Candolim


4 days, which was pretty reasonable if we calculate the cost of hiring a taxi for pick and drop from Aiport & travelling between the beaches of Goa.

Driving on your own in Goa adds more excitement to your vacations. Now you can roam around the places as per your wish and no restrictions on timings. Goa is generally a safe place to wander at any time. Locals understand the importance of security of tourists and privacy. Major economy of Goa is dependent on tourism and hence overall environment is quite favorable for tourists. And Goa is happening during late nights as well.

Driving on your own also brings lot of opportunities to explore the least explored parts of Goa. When we were coming back from Aguada Fort, as noticedneeds like modals and dropdowns.

JavaScript Framework Diet

JavaScript frameworks are great, but overused. Adding small bits of interactivity to an interface shouldn't mean installing kilobytes of dependencies or introducing complex build tools.

It's time for a diet. I'm challenging you to build something without a framework, or follow along and learn something along the way.


Korg Minilogue

Korg’s Minilogue is a powerful 37 key polyphonic analog synthesizer featuring four individual voices under a sleek and simple interface. The synthesizer consists of 2VCOs, 1 VCF, 2 EGs, and 1 LFO. Additionally, it boasts waveshaping abilities that allow users precise control over the oscillators’ harmonics, granting one the ability to dive deep into uncharted sonic territory. The Minilogue’s modulation abilities are also quite spectacular. Users have the option of cross modulation, oscillator synchronization, ring modulation, and a delay with high-pass filtering. The synthesizer contains eight voice modes that allow for things like four note polyphony, staggered triggering, and octave shifts. All of this plus USB, MIDI, and Audio synchronization make the Korg Minilogue an ideal choice for both the studio and the stage.

Minilogue FeaturesSquire as it sounds very much like an early Yes pastiche. This song is saved from ethnic overkill by Hackett’s traditional pace and change of time signatures ably accompanied by Roger King’s killer orchestrations. Hitting the Led Zeppelin trail again In Another Life give off the impression that a cover of Bron-Y-Aur Stomp was about to unfold. Scottish and historic references soon become apparent in both melodies and song. Again just a smattering of overkill which i did not warm to. Not even the wonderful Troy Donockley’s earthy Uilleann pipes at the end which i always enjoy hearing didn’t manage to charm me. A matter of taste methinks.

A subject close to my heart is that of night terrors having suffered with them from a very young age. It


that early stages of adipose tissue expansion are characterized by M2-polarized ATMs and that progressive lipid accumulation within ATMs promotes the M1 polarization, a macrophage phenotype associated with severe obesity and insulin resistance. This polarization was reversed with rosiglitazone treatment, which promotes redistribution of lipids towards adipocytes, improving the adipose tissue lipid storage capacity [@pone.0070810-Prieur1].

In recent years, the interaction between adipose and muscle tissue has been increasingly recognized to play an important role in body weight regulation. Muscle mitochondrial dysfunction, which has been defined as a reduction in muscle oxidative capacity and mitochondrial biogenesis, has been associated with obesity, insulin resistance and type 2 diabetes [@pone.0070810-Hutchison1]--[@pone.0070810-Chung1]. Reduced levels of muscle PPARGC1A, TFAM and MT-CO3 mRNA levels have been used to evaluate muscle mitochondrial dysfunction [@pone.0070810-Hutchison1], [@pone.0070810-Gastaldi1], [@pone.0070810-Chung1].

We are                          0.25±0.20     0.06±0.04[\*](#nt104){ref-type="table-fn"}        0.05±0.03[\*](#nt104){ref-type="table-fn"}      **\<0.0001**
  **ACC1** [+](#nt101){ref-type="table-fn"}                                                 0.019±0.009                    0.021±0.01


                   0.088±0.028                          0.6

Relative gene expression (R.U.).

The data are expressed as mean ± standard deviation.

VWAT, visceral white adipose tissue; SWAT, subcutaneous white adipose tissue; T2DM, Type 2 Diabetes Mellitus; HOMA, Homeostasis Model Assessment; R.U., relative gene expression units.

p\<0.05 compared with non-obese participants, performing Bonferroni post hoc test.

A higher proportion of MCR1 relative to total CD68 macrophages was present in subjects with less body fat \[BMI (r = −0.44, p\<0.0001), fat mass (r = −0.44, p\<0.0001)\] and less fasting glucose concentrations (r = −0.17, p = 0.04). Interestingly, the ratio *MCR1/CD68* was positively associated withof communication network technologies. For instance, persons can now transmit information to the world through electronic news, electronic mail, WWW, and so forth.
Such a computer network functions as an infrastructure of information sharing. The progress of such network has accelerated the establishment of the infrastructures, but the latter merely provides a necessary condition of information sharing but does not necessarily promote information sharing itself.
As individual members mutually open to the public those information, knowledge, know-how, etc, that they have individually accumulated and managed to improve their own intellectual productivity, information sharing may provide the effect of improving intellectual productivity of a group as a whole.
Electronic boards on computer networks and home pages of the Internet have been used as means for sharing information on the computer networks. When


(drug-induced) stupor so they’ll be quiet and compliant.”

For Kamelia, the results were horrific.

By the time Martin and her husband, Mason Martin, adopted her from the orphange, she was diagnosed with institutional autism and her IQ was measured at 35, the low threshold for moderate intellectual disability.

Because she had been malnourished for so long, Kamelia’s head was too small for her body and her ankles were weak and misshapen; she could not walk until she was 3. When the Martins brought her home to Louisiana, where Mason Martin was stationed with the U.S. Air Force, she could hardly communicate or speak, even in Bulgarian.

None of that deterred the Martins, who had three young children of their own when they decided to adopt Kamelia, who they often call “Kami.” Christen/*
 * Driver for USB Mass Storage compliant devices
 * Debugging Functions Source Code File
 *
 * Current development and maintenance by:
 *   (c) 1999-2002 Matthew Dharm (mdharm-usb@one-eyed-alien.net)
 *
 * Developed with the assistance of:
 *   (c) 2002 Alan Stern <stern@rowland.org>
 *
 * Initial work by:
 *   (c) 1999 Michael Gee (michael@linuxspecific.com)
 *
 * This driver is based on the 'USB Mass Storage Class' document. This
 * describes in detail the protocol used to communicate with such
 * devices.  Clearly, the designers had SCSI and ATAPI commands in
 * mind when they created this document.  The commands are all very
 * similar to commands in the SCSI-II and ATAPI specifications.
 *
 * It is important to note that in a


* WITHOUT ANY WARRANTY; without even the implied warranty of
 * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the GNU
 * General Public License for more details.
 *
 * You should have received a copy of the GNU General Public License along
 * with this program; if not, write to the Free Software Foundation, Inc.,
 * 675 Mass Ave, Cambridge, MA 02139, USA.
 */

#include <linux/device.h>
#include <linux/cdrom.h>
#include <linux/export.h>
#include <scsi/scsi.h>
#include <scsi/scsi_cmnd.h>
#include <scsi/scsi_dbg.h>

#include "usb.h"
#include "debug.h"
#include "scsi.h"

void usb_stor_show_command(const struct us_data *us, struct scsi_cmnd *srb)
{
	char *what = NULL;

	switch (srb->cmnd[0]) {
	case TEST_UNIT_READY: what = "TEST_UNIT_READY"; break;
	case REZERO_UNIT: what = "REZERO_UNIT"; break;
	case REQUEST_SENSE: what = "REQUEST_SENSE"; break;
	case FORMAT_UNIT: what = "FORMAT_UNIT"; break;
	case READ_BLOCK_LIMITS: what = "READ_BLOCK_LIMITS"; break;
	case REASSIGN_BLOCKS: what = "REASSIGN_BLOCKS"; break;
	case READ_6: what = "READ_6"; break;
	case WRITE_6: what = "WRITE_6"; break;
	case SEEK_6:GPCMD_STOP_PLAY_SCAN: what = "STOP PLAY/SCAN"; break;
	case GPCMD_READ_DISC_INFO: what = "READ DISC INFORMATION"; break;
	case GPCMD_READ_TRACK_RZONE_INFO:
		what = "READ TRACK INFORMATION"; break;
	case GPCMD_RESERVE_RZONE_TRACK: what = "RESERVE TRACK"; break;
	case GPCMD_SEND_OPC: what = "SEND OPC"; break;
	case MODE_SELECT_10: what = "MODE_SELECT_10"; break;
	case GPCMD_REPAIR_RZONE_TRACK: what = "REPAIR TRACK"; break;
	case 0x59: what = "READ MASTER CUE"; break;
	case MODE_SENSE_10: what = "MODE_SENSE_10"; break;
	case GPCMD_CLOSE_TRACK: what = "CLOSE TRACK/SESSION"; break;
	case 0x5C: what = "READ BUFFER CAPACITY"; break;
	case 0x5D: what = "SEND CUE SHEET"; break;
	case GPCMD_BLANK: what = "BLANK"; break;
	case REPORT_LUNS: what = "REPORT LUNS"; break;
	case MOVE_MEDIUM: what = "MOVE_MEDIUM or PLAY AUDIO (12)"; break;
	case READ_12: what = "READ_12"; break;
	case WRITE_12: what = "WRITE_12"; break;
	case WRITE_VERIFY_12: what = "WRITE_VERIFY_12"; break;
	case SEARCH_HIGH_12: what = "SEARCH_HIGH_12"; break;
	case SEARCH_EQUAL_12: what = "SEARCH_EQUAL_12"; break;
	case SEARCH_LOW_12: what = "SEARCH_LOW_12"; break;
	case SEND_VOLUME_TAG: what = "SEND_VOLUME_TAG";


denied Defendants' motion to compel. Thus, the issues will be consolidated to answer that one question.
¶ 8. This Court applies a de novo standard of review to denials of motions to compel. Vicksburg Partners, L.P. v. Stephens, 911 So.2d 507, 513 (Miss.2005). We divide the question into two lines of inquiry.
I. Whether the Trial Court Erred in Not Finding That the Admissions Agreement Was Procedurally Unconscionable Even Though the Resident and Her Responsible Party Signed the Agreement.
¶ 9. Plaintiffs assert that the admissions agreement is procedurally unconscionable because Brown was incompetent and incapable of entering into a contract, and Goss had no authority to bind Brown.
¶ 10. With regard to Goss's authority to bind Brown, Defendants cite Miss.Code Ann. § 41-41-211 (Rev.2005) which says in pertinent part:
(1) Asurrogate may make a health-care decision for a patient who is an adult or emancipated minor if the patient has been determined by the primary physician to lack capacity and no agent or guardian has been appointed or the agent or guardian is not reasonably available.
(2) An adult or emancipated minor may designate any individual to act as surrogate by personally informing the supervising health-care provider. In the absence of a designation, or if the designee is not reasonably available, any member of the following classes of the patient's family who is reasonably available, in descending order of priority, may act as surrogate:
(a) The spouse, unless legally separated; (b) An adult child; (c) A parent; or (d) An adult brother or sister.
(7) A health-care decision made by a


J. RANDOLPH, J., CONCURS IN PART AND DISSENTS IN PART WITH SEPARATE WRITTEN OPINION JOINED BY WALLER, P.J., AND IN PART BY DIAZ, J.
DIAZ, Justice, Dissenting.
¶ 31. We are faced today with a contract for illegal services. While I agree with the majority that portions of the contract are void due to unconscionability, I must respectfully dissent because the document is wholly void as a matter of law.
¶ 32. It is bedrock law that a contract for illegal services is void. It is now a centuries-old concept that "ex dolo malo non oritur actio," which means that "[n]o Court will lend its aid to a man who founds his cause of action upon an immoral or an illegal act." Morrissey v. Bologna, 240 Miss. 284, 300-01, 123 So.2dor controversy arise between the Parties or be asserted against any of the Facility's owners, officers, directors, or employees, the settlement thereof shall be for actual damages not to exceed the lesser of a) $50,000 or b) the number of days that Resident was in the Facility multiplied times the daily rate applicable for said Resident. This limitation of liability shall be binding on the Resident, Responsible Party, and the Resident's heirs, estate and assigns."
[3]  Section C8 reads verbatim: "The Parties hereto agree to waive punitive damages against each other and agree not to seek punitive damages under any circumstances."
[4]  The pertinent portion of section C5 reads verbatim in bold print: "The Resident and Responsible Party further agree to indemnify and hold harmless the Facility from


layer 4 is deposited over the substrate 1. The amorphous silicon layer 4 is formed of an amorphous silicon doped with phosphorus at a concentration of approximately 2.0E20 atoms/cm3. As shown in FIG. 1B, an oxide film 5 is deposited over the substrate 1, and subjected to photo-etching to remove portions of the oxide film 5 and leave the oxide film 5 in a region covering the contact hole. Then, the patterned oxide film 5 is used as a mask in selectively removing the amorphous silicon layer 4. An amorphous silicon layer is deposited over the substrate 1, and subjected to anisotropic etching to form sidewall amorphous silicon layers 6 at sides of the oxide film 5. In this instance, the sidewall amorphous silicon layers 6 and theof a method for fabricating a box-type capacitor.
Referring to FIG. 2A, an interlayer insulating film 3 is deposited on a semiconductor substrate 1 having an impurity region 2 formed therein, and a portion of the interlayer insulating film 3 over the impurity region 2 is selectively removed to form a contact hole for a capacitor storage electrode. Then, an amorphous silicon layer 4 is deposited over the substrate 1. The amorphous silicon layer 4 is formed of amorphous silicon doped with phosphorus at a concentration of approximately 2.0E20 atoms/cm3. As shown in FIG. 2B, an oxide film 5 is deposited over the substrate 1. As shown in FIG. 2C, the oxide film 5 and the amorphous silicon layer 4 are subjected to photo-etching to remove portions of the


oxide film 5 and the amorphous silicon layer 4 and leave the oxide film 5 and the amorphous silicon layer 4 in a region covering the contact hole. The oxide film 5 is then removed entirely, thereby completing a box-type capacitor lower electrode 7. As shown in FIG. 2D, silicon seeds are formed on a surface of the lower electrode using a seeding gas (Si2H6 or SiH4) at approximately 570xcx9c620xc2x0 C. in HSG-Si forming equipment, and the silicon seeds are annealed to form HSG-Si 8 with a rugged surface. Thus, a box-type lower electrode with HSG-Si and a mushroom shape can be formed. Though not shown, by forming a dielectric film and an upper electrode in succession on the lower electrode, a capacitor is completed.
However, the related artreceive my order on 3/15 but received it ALL on 3/7. Yay!!! You won't be disappointed if you go decide to order these gift tags. FYI, I needed to purchase a few more sheets of gift tags and customer service was so very accommodating and were able to add to my order since it had not gone to print. Super nice reps!!!"

A string of sweet and cuddly stuffed animals stretches across the bottom of this charming gift tag from Petite Alma,
giving your friends and family members even more reason to gush over your new baby's arrival!This Cuddly Parade design from ...


Weiner May Feel Symptoms of Grief After Fall from Grace

While the jury is still out on whether just-resigned Rep. Anthony Weiner is addicted to sexting and other lewd Internet behavior, experts say his fall from grace may take a toll on his mental health, addiction or not.

Weiner, 46, announced his resignation today, 10 days after the news conference where he admitted to lying about sexual behavior with strangers, including a former porn actress, through social media sites such as Twitter and Facebook.

"The extent to which this might impact an individual depends a great deal on their personal coping resources, personal support system and overall resilience in the context of their pre-event psychological make-up," said Dr. Martin Binks, clinical director and CEO of Binks Behavioral Health.

Binks said the themelose that support, and the feelings of loss and grief can become amplified.

Dr. Kenneth Robbins, clinical professor of psychiatry, said that Weiner's desire and ability to change will have a lot to do with how much he wants to save his marriage.

"There are few people who feel good about this kind of private sex life," said Robbins. "It's exciting and arousing, but it's a struggle to feel good about a part of their sexuality that the culture doesn't approve of, so they make it a secret.

"It takes great effort and concentration to make significant change to ourselves," added Robbins. "For most people, the only way [to change] is because something causes them significant anxiety. So I guess the question is: How anxious does this make the various people


/*
 * Licensed to Green Energy Corp (www.greenenergycorp.com) under one or
 * more contributor license agreements. See the NOTICE file distributed
 * with this work for additional information regarding copyright ownership.
 * Green Energy Corp licenses this file to you under the Apache License,
 * Version 2.0 (the "License"); you may not use this file except in
 * compliance with the License.  You may obtain a copy of the License at
 *
 * http://www.apache.org/licenses/LICENSE-2.0
 *
 * Unless required by applicable law or agreed to in writing, software
 * distributed under the License is distributed on an "AS IS" BASIS,
 * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 * See the License for the specific language governing permissions and
 * limitations under the License.
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the thalamus and PBN. Dual retrograde labeling with fluorescence dyes was attempted. In each rat, tetramethylrhodamine-dextran amine and Fluoro-gold were stereotaxically injected into the PBN and thalamic regions, respectively. The proportion of the dually labeled Vc cells in the total population of all labeled Vc cells was about 20%. More than 90% of the dually labeled neurons were distributed in lamina I (marginal zone), less than 10% of them were located in lamina II (substantia gelatinosa), and only a few (about 1%) were found in lamina III (magnocellular zone). The results indicate that some Vc neurons in the superficial laminae mediate nociceptive information directly to the PBN and thalamus by way of axon collaterals and that the vast majority of them project to the ipsilateral PBN and contralateralstays with us when he could do so much better on his own. Perhaps it’s out of genuine love for us – but I suspect guilt of leaving us behind is the truth.

He is not like us, like Tobias and I. He thinks of himself as a hero, a survivor who must lead the pack to safety. He is vain. As we wish for death, he wills for life and that is what will kill him. I have learnt that the universe does not care for optimism.

I am crashing through the undergrowth recklessly, dragging Tobias along. He does not protest. Our days are mostly like this – walking, eating when we can forage some morsels, sleeping fearfully in case we do not wake up again. Our bodies are


C-N and C-C couplings, partial oxidations, and reductions. In all cases, well-known products were formed but very rarely also isolated. As compared to conventional homogeneous organic synthesis, the photocatalytic reaction mode is of no advantage, although the opposite is quite often claimed in the literature. It is also noted that a high quantum yield does not implicate a high product yield, since it is measured at very low substrate conversion in order to minimize secondary photoreactions. That is especially important in semiconductor photocatalysis since photocorrosion of the photocatalyst often prevents long-time irradiation, as is the case for colloidal metal sulfide semiconductors, which in general are photochemically too unstable to be used in synthesis. In this Account, we first classify the numerous organic photoreactions catalyzed by semiconductor powders. The- (-9 - -21 - 6)?
-8
What is -3 + -1 - (0 - -3) - -7?
0
What is the value of 3 + -4 + 5 + -6 - 8?
-10
What is the value of -10 - -14 - (8 - -1)?
-5
Evaluate 11 - (24 + -18 + 8).
-3
Evaluate 6 - (-21 + 15) - (0 + 5).
7
What is 0 - -7 - (-2 + 5)?
4
3 + -1 + (43 - 43)
2
What is the value of (-8 - -7) + (7 - (2 - 1))?
5
Evaluate 45 - 52 - (-17 - -3).
7
Evaluate -8 + 4 + (6 - 6).
-4
Evaluate 3 + -4 + -3 + 2.
-2
Evaluate -1 - (2 + -1) - (18 - 17).
-3
Calculate -2 + -2 - (-6 - -1).
1
What is the value of 4 + 4 +


and that the Haileys adequately alleged a cause of action for intentional infliction of emotional distress. We therefore reverse the judgment.

I

Factual and Procedural Background
Blue Shield is a health care service plan licensed and regulated by the Department of Managed Health Care. (§ 1341, subd. (a).) To obtain coverage under a Blue Shield individual health contract, applicants must qualify based on their medical and health history. Accordingly, applicants must complete an application requesting specific information regarding their medical history. In signing the application, the applicant attests to the accuracy and completeness of the responses, and acknowledges the plan may revoke coverage if the applicant furnishes false or incomplete information.
Before issuing a contract, Blue Shield evaluates the health care application by assigning a point value to the applicant's past andproviders to provide surgery, treatment, care, and physical therapy in an amount exceeding $457,000.
On June 1, 2001, Blue Shield sent the Haileys a letter informing them their health insurance coverage had been cancelled retroactively to December 15, 2000, the date Blue Shield issued the policy. Blue Shield based its cancellation on the Haileys' failure to disclose medical information Blue Shield had received from Los Alamitos Medical Center, which disclosed that in October 2000, Steve had been seen "for dysphagia, stricture/stenosis of the esophagus, essential hypertension, and a reported weight of 285 lbs." The letter noted the total amount of claims submitted during the period of February 6, 2001 to May 14, 2001 was $457,163.30. The letter demanded the Haileys pay Blue Shield $60,777.10, the difference between the amount


must "show that the plaintiff cannot establish at least one element of the cause of action.... [Fn. omitted.] [T]he defendant need not himself conclusively negate any such element...." (Aguilar v. Atlantic Richfield Co. (2001) 25 Cal.4th 826, 853, 107 Cal.Rptr.2d 841, 24 P.3d 493.) If the defendant makes this showing, the burden shifts to the plaintiff to show a triable issue of fact as to that cause of action or defense. (Code Civ. Proc, § 437c, subd. (p)(2).) We must view the evidence in the light most favorable to the plaintiffs as the losing parties. This means liberally construing their evidentiary submissions, strictly scrutinizing defendants' evidence and resolving any evidentiary doubts or ambiguities in plaintiffs' favor. (Wiener v. Southcoast Childcare Centers, Inc. (2004) 32 Cal.4th 1138, 1142, 12for insurance, according to the risk he presents, until after insurance has been purchased and a claim has been made. [Fn. omitted.] Although the insurer may ask an applicant for some underwriting information before it issues the policy, it will not follow up on that information until after a significant claim arises. Only after a claim has arisen will the insurer examine the application and request additional information to see whether the applicant could have been excluded from coverage. [Fn. omitted.] [¶] An insurer relying upon post claim underwriting, `instead of looking to pay the claim ... look[s] for all the things in the application that [it] might be able to dig up ... to rescind the policy.'" (Cady & Gates, Post Claims Underwriting (2000) 102 W.Va. L.Rev.


The insurer controls when the underwriting occurs.... If the insured is not an acceptable risk, the application should [be] denied up front, not after a policy is issued. This allows the proposed insured to seek other coverage with another company since no company will insure an individual who has suffered serious illness or injury." (Lewis v. Equity Natl. Life Ins. Co. (Miss. 1994) 637 So.2d 183, 188-189, original italics.)
In the present case, the record demonstrates Blue Shield conducted an extensive investigation into Steve Hailey's medical history after receiving a claim stemming from Steve's hospitalization for intestinal ailments. In contrast, Blue Shield apparently did little or no investigation into whether the medical information Cindy *800 provided on the application was accurate. Instead, Blue Shield performed its risk assessment onthe assumption the application contained no errors. Upon receiving a hospitalization claim under the plan, however, Blue Shield launched an investigation in which it obtained extensive medical records.
Blue Shield argues that section 1389.3's prohibition on postclaims underwriting does not affect its right to perform a postclaims investigation. As one court observed, however, "the concept of `postclaim underwriting' itself is nebulous, particularly because it is difficult to draw a distinction between post-claim eligibility investigation and post-claim underwriting." (Northwestern Mut. Life Ins. Co. v. Babayan (3d Cir.2005) 430 F.3d 121.) This difficulty arises because postclaims investigation and postclaims underwriting involve a common activity: Research into a subscriber's precontract health after a claim is made to determine whether to rescind the plan due to misrepresentations or omissions in the original application.


insurance broker failed to disclose the subscriber's diabetes in the application. Although recognizing the general principle of postclaims underwriting, the court concluded Illinois law did not require the provider to perform a preclaims investigation of the subscriber's health.
Commenting on Brandt, one law review article noted: "The `no investigation rule' of the Illinois court thus permits insurers to defeat the very nature of the aleatory contract of insurance.... [¶] [B]ecause the insurer has dealt with the insured as if there is coverage, the insured has stopped seeking additional sources of insurance.
[A]n insurer must do its investigation before issuance of the policy to allow `the proposed insured to seek other coverage with another company [in the event of rejection] since no company will insure an individual who has suffered seriousresponses to the health plan application questions, Blue Shield cites a number of insurance cases. (See Mitchell v. United National Ins. Co. (2005) 127 Cal.App.4th 457, 476, 25 Cal.Rptr.3d 627, and cases cited therein.) But each insurance case dealing with rescission since 1935 was decided either implicitly or expressly under Insurance Code section 331, which provides: "Concealment, whether intentional or unintentional, entitles the injured party to rescind insurance." (Ins. Code, § 331.) As Blue Shield emphasized both to the trial court and on appeal, Blue Shield is not an insurance company, and the Insurance Code and administrative regulations promulgated thereunder are not directly applicable to health care service plans.[6] (See Williams v. California *803 Physicians' Service (1999) 72 Cal.App.4th 722, 729, 85 Cal.Rptr.2d 497; Ins.Code, § 740, subd.


would present a factual issue. (Id. at p. 681, 79 Cal.Rptr. 106, 456 P.2d 674.) The court's description of the factors the trial court should consider in determining whether the insurance company conducted a reasonable investigation included "the cost of obtaining the information from the Department of Motor Vehicles, the availability of this information from the department or elsewhere ..., *804 and the general administrative burden of making such an investigation. [Fn. omitted.] These factors must be weighed against the importance of the protection of innocent members of the public against the consequences of automobile owners driving with voidable liability policies." (Id. at p. 682, 79 Cal.Rptr. 106, 456 P.2d 674.)
As in Barrera, public policy favors requiring a health care services plan to demonstrate reasonable care in ensuringcourts have rejected liability where, for example, the insurer simply delayed or denied insurance benefits (Coleman, supra, 132 Cal.App.4th at p. 417, 33 Cal.Rptr.3d 744), refused to accept a settlement demand within policy limits (Isaacson v. California Ins. Guarantee Assn. (1988) 44 Cal.3d 775, 788-789, 244 Cal.Rptr. 655, 750 P.2d 297), failed to investigate a claim and accused the insured of "`trying to put something over on'" the insurer (Ricard v. Pacific Indemnity Co. (1982) 132 Cal.App.3d 886, 889, 895, 183 Cal.Rptr. 502), or violated its duties under Insurance Code section 790.03 by misleading the claimant as to the *807 applicable statute of limitations and advising the claimant not to obtain the services of an attorney. (Coleman, supra, at pp. 416-417, 33 Cal.Rptr.3d 744.)
Conversely, in Fletcher v. Western


development in order to help as many others as possible achieve success with their education, development and goals.

His viewpoint is:

“There is no out of the box approach. Optimal is in the eye of the beholder. Start with intention, build a good plan take the actions to integrate with that plan but most importantly evolve the plan continually to ensure it establishes your individual best approach and journey. The science is important because it supplies us the evidence and theory we need to build foundations for our plans but correct application of that information with respect to one's circumstances and desired outcome is what separates the successful from the frustrated and stagnant. I consider adherence, balance, mindset and consistency as the most integral components of a successful protocol.”while yes this would have to be a back end solution, how do you update the front end then, so that they are on the logout screen when they reawaken the laptop or computer?

A:

UPDATE
Regarding the WebSocket request, I assume you're using Laravel WebSockets with pusher. Pusher.io does not support timeout, you can read this support article "Do you plan to add a connection timeout feature to the Channels pusher-js client library?". You can test it out if you enable Laravel debug mode (APP_DEBUG=true inside .env) and beggin laravel-websockets from terminal (php artisan websockets:serve) so you can see the output log events. If you try to close the laptop lid or set computer to hibernation mode (sleep), you won't see any messages regarding this event. You cannot do it


redirect the user to the logout route.
Example JS client code:
// Set a variable to check previous time
let clientSession = new Date;

// Setup the client session checking timer
let clientSessionTimer = setInterval(() => {
  const now = new Date;
  // Get how many seconds have passed since last check
  const secondsSpan = (now - clientSession) / 1000;

  // If the 1 minute timer has exceeded 15 minutes trigger logout and clear timer
  if (secondsSpan > (60 * 15)) {
    // For some reason JS halted execution, so we'll proceed with logging out
    clearInterval(clientSessionTimer);
    window.location.href = '/logout/session'
  } else {
    // The timer runs as it should, update the clientSession time
  the right of metropolitan rank was restored to the oldest bishop of the province, who was the bishop of Braga. From this time, until the Muslim conquest of Hispania (711), he retained the supremacy over all the sees of the province.

In 1110 Pope Paschal II restored Braga to its former metropolitan rank. When Portugal separated from León in 1139, Braga assumed even greater importance. It contested with Toledo the primacy over all the Iberian sees, but the popes decided in favour of the latter city. Since it retained as suffragans the dioceses of Porto, Coimbra, Viseu, Bragança-Miranda do Douro, Aveiro and Pinhel. In 1390 Braga was divided to make the Archdiocese of Lisbon, and in 1540 its territory was again divided to create the Archdiocese of Évora.


on the consent form that she had the opportunity to view the video tape).
The Act states that ADPH "may charge a reasonable fee based on the cost of producing the materials and video tape." Id. at § 26-23A-(5)(c). According to a letter dated September 18, 2002, ADPH informed the Plaintiffs that the printed information packages may be purchased at a cost of $4.00 each, plus $6.00 shipping and handling. See Memorandum in Support of Plaintiffs' Motion for Summary Judgment (Doc. # 70), Exhibit B. As a service to large volume consumers, however, ADPH stated that it will waive the shipping and handling fees on orders that are received between certain specified dates each year. Id. ADPH also expressed its intent to charge the Plaintiffs $50 for each copyrequired to be a content-neutral player in the marketplace of ideas. See Nat'l Endowment for the Arts v. Finley, 524 U.S. 569, 598, 118 S.Ct. 2168, 141 L.Ed.2d 500 (1998) (Scalia, J., concurring) ("It is the very business of government to favor and disfavor points of view on (in modern times, at least) innumerable subjects  which is the main reason we have decided to elect those who run the government."). Indeed, the State may express its views through a variety of means available to it. For example, the State may fund policies and programs that further its ideological preferences. See, e.g., Rosenberger v. Rector & Visitors of the Univ. of Va., 515 U.S. 819, 833, 115 S.Ct. 2510, 132 L.Ed.2d 700 (1995) ("[W]hen the government appropriates public


so many more inmates are not ready for college courses because they can barely read. We owe these inmates the high school education and literacy training that can prepare them to apply for those Pell grants. In not including increased funding for secondary education in prisons in his criminal justice reform agenda, President Obama is ignoring the most effective way to reduce recidivism.

Consider that the 2013 Rand study that correctional education advocates rely on as evidence of education’s power to reduce crime does not specifically tease out the effect of higher education on recidivism. The report states that high school education can have a great impact in reducing recidivism. This effect is most likely because these inmates are learning to read in the GED programs offered. Learning to'in'        : 1.0 / 2.54,
    'ft'        : 1.0 / 2.54 / 12.0,
    'yd'        : 1.0 / 2.54 / 12.0 / 3.0,
    'mile'      : 1.0 / 2.54 / 12.0 / 5280,
    'lightyear' : 1.0 / 2.54 / 12.0 / 5280 / 5.87849981e12,
}

# convert 25.4 mm to inches
val = 25.4
units_from = 'mm'
units_to = 'in'

base_value = val / factors[units_from]
ret = base_value * factors[units_to  ]
print ret, '==', 1.0, '->', ret == 1.0

Let me first say that I am pretty sure what is going on here.  I have seen it before in C,


value for *f*ND can be obtained, then the assumption of passive diffusion across the BBB can be tested. Under the conditions of passive diffusion, at equilibrium, *C*~FT~ = *C*~FP~, and Eq. [3](#Equ3){ref-type=""} is simplified to:$$\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}
                \usepackage{amsfonts}
                \usepackage{amssymb}
                \usepackage{amsbsy}
             without inducing intolerable muscarinic-related side effects.

Methods {#Sec2}
=======

Radiosynthesis of \[^11^C\]GSK1034702 {#Sec3}
-------------------------------------

\[^11^C\]GSK1034702 was prepared as described previously \[[@CR5]\] via a palladium-catalysed cross coupling reaction between GSK1804165A and \[^11^C\]CH~3~I (Figure [1](#Fig1){ref-type="fig"}).Figure 1**Synthesis route for \[** ^**11**^ **C\]GSK1034702.**

Evaluation of \[^11^C\]GSK1034702 kinetics in the *Papio anubis* brain {#Sec4}
----------------------------------------------------------------------

### Study design {#Sec5}

The brain distribution of carbon-11-labelled GSK1034702 (\[^11^C\]GSK1034702) was conducted in two anaesthetised baboons (*P. anubis*), to assess its transport across the BBB. These studies were conducted at Columbia University Medical Center, New York. The study was approved by the Columbia University Institutional Animal Care and Use Committee (IACUC).

Two adult baboons were studied over a 6-week period. Subject A (an ovariectomised female) received two injections of \[^11^C\]GSK1034702 22 days apart, while subject B (male) received a single injection of \[^11^C\]GSK1034702. Each experimental session included a single


scan. During the scanning day, each subject received a baseline \[^11^C\]GSK1034702 scan, followed by a single 5-mg oral dose (p.o.) of GSK10347012 and a subsequent \[^11^C\]GSK1034702 scan approximately 4 h post-dose. Subjects returned to the clinic for a follow-up visit 7 to 14 days following the oral dose of GSK1034702.

### Data acquisition {#Sec10}

Dynamic PET data were acquired using a Siemens Biograph 6 Truepoint with TrueV PET-CT (Siemens Healthcare, Malvern, PA, USA) in three-dimensional (3D) mode. A computed tomography (CT) scan was acquired for attenuation correction of PET data prior to administration of the radiotracer. A cannula was inserted under local anaesthesia into the radial artery, contralateral to the tracer injection site, and used to collect arterial blood samples to estimate the time course of radioactivity and metabolism of GSK1034702. Thegrey and white matter; plus sign, WM = all cerebral white matter. Solid lines are two tissue compartmental model fits. For each subject, a regular-sized rectangle (432 mm^3^) was manually placed over the area of highest signal in the medial temporal lobe (MTL), centred in the hippocampus; this is presented in the data as the MTL ROI.Figure 5**\[** ^**11**^ **C\]GSK1034702 in Subject 4 in the human brain.** Tracer \[^11^C\]GSK1034702 PET data - integral images 0-120 min in subject 4. Post dose 5 mg of GSK1034702 \[^11^C\]GSK1034702 PET data - integral images 0-120 min in subject 4. *K* ~1~ = rate constant for transfer from arterial plasma to tissue (mL.cm^−3^.min^−1^). *V* ~T~ = volume of distribution (mL.cm^−3^). Regions of interest: MTL = medial temporal lobe (ROI defined above), cerebellum, thalamus and striatum and cortex = sum of cortical regions (includes grey and white


equilibrium dialysis. The bound fractions in plasma and brain were similar in all species tested (Table [4](#Tab4){ref-type="table"}).Table 4***In vitro*** **plasma protein binding and brain tissue binding of GSK1034702SpeciesPlasma protein binding (%)*f*** ~**P**~**Brain tissue binding (%)*f*** ~**ND**~Mouse48.2 (±1.2)0.5286.7 (±0.6)0.13Rat (CD)47.2 (±1.4)0.5387.7 (±0.5)0.12Rat (LH)45.5 (±1.5)0.5584.9 (±1.0)0.15Dog44.5 (±3.6)0.5681.8 (±1.8)0.18Monkey41.7 (±2.7)0.5883.2 (±1.1)0.17Human55.8 (±3.6)0.44N/APlasma protein binding and brain tissue binding of GSK1034702 evaluated by equilibrium dialysis over 5 h at concentration of 1 μg/mL. Values represent mean ± standard deviation from *n* = 6 determinations, *f* ~P~ = plasma-free fraction, *f* ~ND~ = brain-free fraction. CD = Sprague Dawley rat and LH = Lister hooded rat.

The *in vitro* equilibrium dialysis *f*~P~ values for the monkey and human plasma (0.58 and 0.44, respectively) were consistent with the values obtained by ultrafiltration in the course of the PET studies in baboon and human plasma *in vivo* (0.54 and 0.45, respectively).L. William Seidman Center Dedication

Many friends of the university celebrated the dedication of the L. William Seidman Center in October. The Seidman Center is the new home for the Seidman College of Business and a fitting tribute to the life and legacy of Bill Seidman. Back to events.


getting that time back.

A:

As I read your question, you are handling recurring payment schedules, refunds, and validations, using the code which might be deleted.  The code currently works fine as far as you know.

PRO 3: Because the EFT company did not handle recurring payment schedules, refunds, and validation, I wrote my own application to do it. Although the CC company's API permitted this functionality, I opted to use mine instead so that I could streamline my code. now that EFT is out of the picture, I can delete all this confusing code and just rely on the CC company's system to manage recurring billing, payment schedules, refunds, validations etc...
CON 2: with regards to PRO 3, it takes time to build functionality that integrates the payment system moreCheck out our new site Makeup Addiction

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I don't always watch porn but when I do, it's peer-reviewed & highly-cited


3. Let j(p) = -22*p**4 + 35*p**3 - 289*p**2 - 13. Let d(c) = -6*j(c) + 26*s(c). Find the third derivative of d(k) wrt k.
48*k + 144
Let u(i) be the first derivative of -i**4/2 - 5*i**3/3 + 5*i**2/2 + 1. Let r(f) be the second derivative of u(f). Differentiate r(j) wrt j.
-12
Let q = 128 + -117. Differentiate 6 - q*a + 8 + 22 with respect to a.
-11
Let c(p) be the second derivative of -p**11/6930 + p**7/840 + p**4/6 + 7*p. Let h(b) be the third derivative of c(b). Find the third derivative of h(a) wrt a.
-960*a**3
Let b(c) = c**2 + 2*c - 2. Let l(i) = 38*i**2 - 12*i + 77. Let n(z) = 5*b(z) + l(z). What is the derivative of n(o) wrt o?
86*o -(image, error, cache, url) in
    dispatch_async(dispatch_get_main_queue()) {
         let shadowPath = UIBezierPath(rect: cell.societyImage.bounds).CGPath
         cell.societyImage.layer.shadowColor = UIColor(white: 0.7, alpha: 0.7).CGColor
         cell.societyImage.layer.shadowOffset = CGSizeMake(3, 3)
         cell.societyImage.layer.shadowOpacity = 0.4
         cell.societyImage.layer.masksToBounds = false
         cell.societyImage.layer.shadowPath = shadowPath.CGPath
         cell.societyImage.layer.radius = 2
    })
})


Secretion and metabolism of monomeric human calcitonin: effects of age, sex, and thyroid damage.
Some data suggest that human calcitonin (CT) secretion is lower in women than in men, decreases with age and the menopause, and is absent in thyroidectomized persons. To further explore CT secretory physiology, we have studied basal and calcium-stimulated plasma immunoreactive CT (iCT) and silica-extractable monomeric CT concentrations in 148 healthy volunteers and 33 patients with a history of thyroid damage (total or subtotal thyroidectomy, radioiodine treatment for thyrotoxicosis). Both whole-plasma iCT and extractable CT levels were lower basally and after calcium infusion in women than in men, basal levels being reduced about 50% and calcium-stimulated values about 75% from those of male subjects. There were no significant changes in basal iCT or extractable CTa pingu is passing the switch, the door
    will open. */
class SwitchDoorSwitch : public WorldObj
{
private:
  /// The bottom/middle pos of the switch
  Vector3f switch_pos;
  Sprite switch_sur;
  std::string m_target;
  bool is_triggered;
  SwitchDoorDoor* m_door;

public:
  SwitchDoorSwitch(const ReaderMapping& reader);

  void on_startup();
  void draw (SceneContext& gc);
  void update ();

  /// The switch and the door should stay above the pingus
  float get_z_pos() const { return 100; }
  void set_pos(const Vector3f& p) { switch_pos = p; }
  Vector3f get_pos() const { return switch_pos; }

private:
  SwitchDoorSwitch (const SwitchDoorSwitch&);
  SwitchDoorSwitch& operator= (const SwitchDoorSwitch&);
};

} // namespace WorldObjs

#endif

/* EOF */


the system. []{data-label="schematic_trap"}](schematic_trap.pdf){width="6.0cm" height="4.8cm"}

Trapping due to confinement magnetic fields and/or tapered laser beam waists in optical lattice experiments are modeled by a parabolic trapping potential (Fig. \[schematic\_trap\]). The last term in Eq. (\[bhmodel\]) decreases the density as the distance from the center of the system increases for $\gamma >0$. As a result the spatially varying chemical potential mixes phases within the trap. Identifying individual phases within the trapped system requires a local observable but most experiments currently rely on bulk time of flight imaging. We study the boson core compressibility as a candidate quasi-local observable that uses bulk time of flight data to measure a single phase within the trap. Core quantities can be compared with single-site local quantities to show that only one phase in the trap is measured.

Local\rho_{s}=\frac{W^{2}}{2t\beta\langle n \rangle}.
 \end{aligned}$$ The superfluid stiffness, as defined, is a manifestly bulk quantity because macroscopic occupation of a single mode in the presence of interactions implies that perturbations lead to non-local response.

Significant spatial inhomogeneity due to trapping suggests that *local* measures of compressibility and stiffness will be more informative. The local compressibility [@wessel:2004]: $$\kappa_{i}=\frac{\partial \left \langle n \right \rangle}{\partial \mu _{i}}=\beta \left[ \left \langle n_{i}n \right \rangle -\left \langle n_{i} \right \rangle\left \langle n \right \rangle\right],
 \label{localk}$$ measures the average density fluctuations at a single site in comparison to the total average density. Note that the local compressibility of a trapped system becomes equivalent to $\kappa$ in a uniform system only if $\kappa_{i}$ is summed over a smooth and large volume of the trapped system. For large


absence of mean-field superfluidity, the mean-field Hamiltonian becomes: $$\begin{aligned}
H^{MF} =\frac{U}{2} \sum_{i}n_{i}  \left ( n_{i} -1 \right )- \sum_{i}\mu_{i}  n_{i}
\label{meanfieldmodel}\end{aligned}$$ In this limit the model is diagonal and can be solved exactly. The total mean-field energy of the $\psi=0$ system is then: $$E = \sum_{i=1}^{N_s} \left [\frac{U}{2}\left \langle n_{i} \right \rangle\left (\left \langle n_{i} \right \rangle-1  \right )-\mu _{i}\left \langle n_{i} \right \rangle \right ]$$ Note that the energy increases with $\langle n_{i} \rangle$. We can count energy eigenvalues using integer local number occupancy: $E_m=Um(m-1)/2-\mu m$, with $m=0,1,2,...$. In regimes where we can separate energy scales according to occupancy our definition of core compressibility becomes an accurate representation of the total compressibility because we can locate parameter regimes where singly and triply occupied sites cantracks $\kappa$ *only* for densities between 1 and 2. Otherwise $\kappa_{c}^{d}\approx0$ when the system shows few triple occupancies ($\mu/U\lesssim1.75$). Above $\mu/U\approx1.75$ the core compressibility based on double occupancies fails to track the total compressibility. Here we find instead, $\kappa\approx\kappa_{c}^{t}$. Fig. \[uniformvsmu\_withMFTresults\] reveals two key features of $\kappa_{c}^{d}$: i) there is a range of chemical potentials for which we find $\kappa\approx\kappa_{c}^{d}$ and ii) for all lower chemical potentials we find $\kappa_{c}^{d}\approx0$. Thus edge effects induced by trapping (which lowers the chemical potentials near the edges) will have very little impact on $\kappa_{c}^{d}$ in comparison to $\kappa$. The vanishing of the core compressibilities at low $\mu$ is a key property that allows the exclusion of edge effects in trapped systems when measuring $d$ for the entire trapped system.

![(Color online) The symbols


to the eye.[]{data-label="uniformvsmu_withMFTresults"}](Uniformvsmu_kcorektriplek.pdf){width="50.00000%"}

Fig. \[uniformvsTemperature\_nospace\] compares MFT with QMC for the density, the compressibility, and the core compressibility in a uniform system. Parameters were chosen to host an incompressible Mott insulator at low temperatures. Here we move along line “a” in Fig. \[phasediagram\]. Above $T/U\approx 0.025$ ($T/U\approx0.15$) thermal fluctuations induce double (triple) occupancies. The bottom panel shows that the density starts to deviate from unity when the temperature is increased. But the top panel shows that for $T/U\lesssim 0.15$ we find $\kappa\approx\kappa_{c}^{d}$. At larger temperatures significant triple occupancies spoil the connection between $\kappa_{c}^{d}$ and total compressibility. The solid lines draw the MFT. Here the MFT is nearly indistinguishable from the QMC. We conclude that weak thermal fluctuations allow measurements of $\kappa$ with $\kappa_{c}$.

![(Color online) Panels (a) and (b) compare quantum Monteto show that the core compressibility can be used to track phase transitions out of the incompressible Mott insulator state. We also find that the core compressibility agrees with the total compressibility even in the superfluid state provided we work at low densities.

Trapped Systems {#qmctrap}
===============

We now turn to studies of the compressibility and stiffness in a more realistic setting, the trapped Bose-Hubbard model. We consider regimes with non-zero $\gamma$ in Eq. (\[bhmodel\]). We first show that core quantities accurately capture local quantities. Specifically, we find regimes where $\rho^{d}_{s}$ and $\kappa_{c}^{d}$ accurately capture the local stiffness and the local compressibility, respectively, in the center of the trap. We then construct a recipe for scaling the core compressibility. By increasing particle number experiments can be used to access the thermodynamic limit


the approximate number of sites in the core, $ N_{R_{\text{c}}}$, instead of $N_{s}$ : $$\kappa_{c}^{d}\left( R_{c} \right)\equiv \frac{1}{2N_{R_{c}}}\frac{\partial }{\partial \mu }
\left \langle \sum_{i}^{N_s} n_{i}\left ( n_{i}-1 \right )\right \rangle.
\label{coreklocal}$$ Here the sum is kept over all sites, $N_s$. Because in a trapped system the double occupancy excludes the edge sites. The sum will then effectively run over $\approx N_{R_{c}}$ sites.

![(Color online) Quantum Monte Carlo results showing the local density (a) and superfluid stiffness (b) as a function of the distance from the center, $R_{i,0}$, for different hoppings and $L=12$. The solid lines are guides to the eye. Parameter values ($\mu/U =0.76$, $T/U=0.025$, and $\gamma/U=0.035$) are chosen to host a Mott insulator in the core for low hopping but a superfluid in the core for larger hopping. Note thatfor $t/U\gtrsim 0.03$ the system also shows a finite local stiffness for all $R_{i,0}$ due to finite size effects. At these temperatures and system sizes the edge superfluid couples to the core superfluid. Double occupancy based measures exclude these edge effects. []{data-label="TrappedvsHopping_rhoandn"}](TrappedvsHopping_rhoandn.pdf){width="50.00000%"}

We now use QMC to compare a quantity we interpret mathematically as the local compressibility of the sample core, Eq. (\[localcompressrc\]), and a quantity that we propose can be used to effectively measure the core compressibility in experiments, Eq. (\[coreklocal\]). We choose parameters so that the core of the trapped system moves along a line equivalent to “b” in Fig. \[phasediagram\]. Fig. \[TrappedvsHopping\_rhoandn\] plots the local stiffness and local density for several $t/U$ to show that for low $t/U$ we have a Mott insulator in the core but for larger $t/U$