*p* = 0.0935, one-way ANOVA with Dunnett's post test, *p*~WT,\ R1346H~ = 0.259, *p*~WT,\ T797M~ = 0.540). In the first 2 hrs of puromycin treatment, the \>250 kDa hCa~V~3.3 signal increased \~40% and \~30% in cells expressing WT and T797M respectively and the levels were not different between the two conditions ([Fig. 3b](#f3){ref-type="fig"}, 2 hr data point, F~(2,20)~ = 17.6, *p* \< 0.001, one-way ANOVA with Dunnett's post test, *p*~WT,\ T797M~ = 0.859). We observed \~15% reduction in the \>250 kDa band in cells expressing R1346H following exposure to puromycin, and the overall protein levels were lower compared to WT ([Fig. 3b](#f3){ref-type="fig"}, 2 hr data point, F~(2,20)~ = 17.6, *p* \< 0.001, one-way ANOVA with Dunnett's post test, *p*~WT,\ R1346H~ = 0.0154). We also showed that GAPDH levels did not decrease following puromycin treatment in cells expressing different Ca~V~3.3 clones over the time course of the experiment ([Fig. 3c](#f3){ref-type="fig"}). Ouraffect the functional properties of hCa~V~3.3 channels using whole-cell recording from the same Flp-In T-REx HEK293 cells expressing FLAG-tagged hCa~V~3.3 as described above. We used 2 mM Ca^2+^ as the charge carrier for conventional whole-cell recording and resolved large Ca~V~3.3 currents that peaked at \~60 pA/pF in cells expressing WT channels. Consistent with our biochemical analyses, hCa~V~3.3 channel current densities in doxycycline-induced HEK293 cells expressing R1346H, but not T797M, were smaller relative to those in cells expressing WT hCa~V~3.3, independent of membrane voltage ([Fig. 4a](#f4){ref-type="fig"}). To compare hCa~V~3.3 currents across a range of voltages, we estimated permeability rates from Boltzmann-GHK fits of individual current voltage data sets from cells expressing WT, R1346H and T797M hCa~V~3.3 ([Fig. 4b](#f4){ref-type="fig"}; *left*). Permeability rate was used as a measure of the overall current flow


Barracuda; Molecular Devices). The large sample sizes, possible from high throughput automated whole-cell analyses, allowed for population analyses of hCav3.3 current densities in cells expressing WT, R1346H or T797M ([Fig. 4a,b](#f4){ref-type="fig"}). Population data, displayed in bee swarm and cumulative frequency plots, illustrate that hCa~V~3.3 currents in cells expressing R1346H hCa~V~3.3 are on average 2-fold smaller compared to WT ([Fig. 4c](#f4){ref-type="fig"}). The cumulative frequency relationships for each condition were bimodal, consistent with two populations of Flp-In T-REx HEK293 cells: one expressing and a smaller fraction not expressing hCa~V~3.3 currents ([Fig. 4c](#f4){ref-type="fig"}). Parameterization of each distribution, allowed by the larger sample size, showed that the percentage of cells not expressing hCa~V~3.3 current was similar among all variants (WT: 16%, T797M: 16%, R1346H: 20%) and that the median hCa~V~3.3 current of([Fig. 6a--c](#f6){ref-type="fig"}. V~1/2-negative~, *p*~WT,R1346H~ = 0.32, and *p*~WT,T797M~ = 0.91. V~1/2-positive~, *p*~WT,R1346H~ = 0.6, and *p*~WT,T797M~ = 1.00. Slope (*k*), *p*~WT,R1346H~ = 0.52, *p*~WT,T797M~ = 0.19. Kolmogorov-Smirnov test followed by Bonferroni correction), kinetics of channel activation from −50 to 20 mV voltages ([Fig. 6d,e](#f6){ref-type="fig"}), rate of channel closing as derived from the time constant of the tail current decay ([Fig. 6f](#f6){ref-type="fig"}. τ~closing~ at--60 mV, *p*~WT,R1346H~ = 0.43, p~WT,T797M~ = 0.97, Kolmogorov-Smirnov test followed by Bonferroni correction), voltage-dependence of channel inactivation ([Fig. 7a,b](#f7){ref-type="fig"}. V~1/2~, *p*~WT,R1346H~ = 0.12, *p*~WT,T797M~ = 0.76. Slope (*k*), *p*~WT,R1346H~ = 0.52, *p*~WT,T797M~ = 0.19, Kolmogorov-Smirnov test followed by Bonferroni correction), and time course of channel inactivation from −50 to 0 mV ([Fig. 7c,d](#f7){ref-type="fig"}). Tail current kinetics provide a measure of the overall rate of channel closing, because the tail potential is below the threshold for channel opening and the slow closing kinetics is a hallmark feature of Ca~V~3 channels, compared to other


current injections of different magnitudes (upper) and bursts of action potentials during the depolarizing current injection (lower). *Right*: Neuron with 72.5% of WT Ca~V~3.3 current density to approximate heterozygosity (50% R/H and 50% WT) does not exhibit rebound bursting following hyperpolarization. (**b**) Relationship between number of rebound spikes and size of hyperpolarizing current injection for a range of Ca~V~3.3 current densities. Percent of Ca~V~3.3 current relative to WT (black) color coded from green (78%) to red (120%). (**c**) The number of spikes during positive current injections depends on the magnitude of the current injection (x-axis), but it is only marginally influenced by Ca~V~3.3 density. Black lines represent current density for WT and R/H heterozygous cells, with same color spectrum as in (**b**), extended to 40% of WT (blue).](srep34233-f8){#f8}
[Effect of calcium antagonists of the verapamil type on regional cerebral blood flow and bioelectric activity of the brain in patients with cerebral infarction].
The authors have studied the regional volume cerebral blood flow (RVCBF) in 25 patients with acute cerebral infarction before and after the intravenous administration of 5-7.5 mg of isoptin and carried out quantitative frequency analysis of the EEG in 20 patients prior to and following the administration of 5 mg of finoptin. It has been revealed that isoptin augments the RVCBF in the infarcted zone, particularly when patients with extensive infarction, edema and atrophy of the cerebral tissue (according to findings of computer-aided tomography) have low baseline levels of the RVCF and somewhat decreases the blood flow in intact zones. The administration of finoptin tended


Background*

Mr. Lawrence C. Karlson has been the Chairman and Chief Executive Officer of Karlson Corporation since 1986. Mr. Karlson is an Advisor to a number of businesses and has been a Private Investor since 1990. He has been Independent consultant for industrial and technology companies since 1995. He provides consulting services to a wide variety of businesses and, as a private investor, invests in companies where he can contribute in a non-executive role to the development ... of the business. In 1983, Mr. Karlson formed Nobel Electronics, an autonomous business unit of AB Bofors. He served as the President and Chief Executive Officer of Pharos AB. He held various positions with Fisher & Porter Company commencing in 1965 and served as its President of U.S. Operations since 1981.Pauli matrices, $v_F \equiv 3 \eta \ell / 2$ is the Fermi velocity (that will be set to 1) with $ \eta \simeq 2.7$ eV the hopping parameter and $\ell \simeq 2.5$[Å]{} the lattice spacing, and $\psi_+^T \equiv (a_+\,\, b_+)$, $\psi_-^T \equiv (a_- \,\, b_-)$ are two-component Dirac spinors, as appropriate for this 2+1-dimensional system ($a$ and $b$ are anti-commuting annihilation operators for an electron in the two sub-lattices). We do not consider short range scattering centres or any other effect mixing the two Fermi points, thus we discuss the physics around a [*single*]{} Fermi point, e.g. $\psi \equiv \psi_+$. The corresponding action is $A =   i \int d^3 x  \bar{\psi} \gamma^a \partial_a \; \psi$, where $\gamma^0 = \sigma_3$, $\gamma^1 = i \sigma_2$, $\gamma^2 = -


exist, but the key issue for graphene is whether those ${\cal Q}^\mu$ can be *practically realized in the laboratory*[@note3].

One of the main results of this work is that the Beltrami pseudosphere[@eisenhart], $d{\ell}^2 = g_{\alpha \beta} q^\alpha q^\beta = du^2 + r^2 e^{2 u/r} dv^2$, with $v\in [0, 2\pi]$, $u\in [-\infty, 0]$ (see Fig. \[Beltrami\]), solves the problem. For this surface the coordinates ${\cal Q}^\mu$ are the coordinates $q^\mu$, and the time coordinate coincides with the laboratory time. To see it, we first write the spatial line element in isothermal coordinates $(\tilde{x}, \tilde{y})$ [@note3], where we use the upper-half plane model of Lobachevsky geometry, valid for any surface of constant Gaussian curvature. Then it is immediate to write the whole line element, including time, in an explicitly conformally flat fashionam that Guillen is gone.Guillen said he loved Castro. In saying this, he was reflecting the beliefs of many Central/South Americans, who admired Castro because he stuck it to the United States.None of those Central/South Americans would ever read, "Against All Hope," the story of Armando Valladares, a Cuban freedom-fighter, who was tortured by Castro.Guillen, like many in the US, rejoiced in the works of Castro and the sexy Che Gueverra, ignoring the price in human blood, as long as the US was being diminished in the exchange.
]]>By: Theophilus T. S.http://natsinsider.com/2012/10/24/the-ever-changing-nl-east/comment-page-1/#comment-172223
Wed, 24 Oct 2012 22:27:18 +0000http://natsinsider.wordpress.com/2012/10/24/the-ever-changing-nl-east#comment-172223"NL and Faraz, you guys were joking about comp picks for Duke right? The only compensation we'll get if he walks is that a certain commenter won't be able to tout him for


Q:

java set path hsqldb

I created a simple application to manage members in a database. This programm is running HSQLDB in server mode; all started from within the programm code. The programm is distributed via Installer and of course the user may choose where to install it in.
Now, I've noticed a most peculiar problem, which I cannot get a grip on. On my win7 notebook, it doesn't matter where I install the app in; it works like a charm. However, on another computer, only installations outside the programm files folder work. Inside programm files it seems like java cannot find the hsqldb.jar. Adding the whole filepath of hsqldb.jar to PATH does not work and on yet another computer, everything works fine again. Any ideas? (all win7)
I shouldnote that not even starting the server manually via the included runserver.bat seems to work.

A:

The problem your facing deals with changes to the UAC.
You can overcome these by been loaded is admin and having UAC set to low, but this is not an ideal solution. (Under what user Java was installed and the application installed also play apart).
A better solution would to try and place the database in a user acceptable location.
I would suggest trying to use the System property user.dir (ie System.getProperty("user.dir");) as the base location.  From here, you can make a directory under AppData\Roaming named after you application and write your application specific data to this location.
This will place your database in, what should be, a writable location for the specific user.
(ps - You


among other things, try to determine whether the plaintiffs were
actually injured.

Of course, the predictable outcome of that inquiry is that the NSA will invoke
various legal privileges against disclosing the evidence necessary to actually
make a determination, ultimately rendering plaintiffs' case impossible to
maintain.

~~~
jdp23
Marcy Wheeler has more in a pair of posts on Emptywheel.

\- one of the three judges said that the plaintiff didn't have standing
because there wasn't explicit evidence that the government was collecting data
from Verizon Wireless. [In a followup post, Marcy notes that a recent IG
report (obtained by Charlie Savage of the NY Times via a FOIA suit) does
explicitly include Verizon Wireless in a list; but this information probably
wasn't known in time to include it in arguments in this suit.]

\- another judge said that there wasn't any evidence theget on with your life.

~~~
cryoshon
I completely reject your fatalistic line of thinking on a few grounds:

1\. You can totally win, provided that you show up with thousands of your
friends and a desire to wreck shit. See the corpse of STASI, which the Western
surveillance apparatus has surpassed in every dimension:
[https://en.wikipedia.org/wiki/Stasi#Storming_the_Stasi_headq...](https://en.wikipedia.org/wiki/Stasi#Storming_the_Stasi_headquarters)
(especially read the part about the headquarters being stormed and unconfirmed
reports of lynchings-- sounds a lot like they lost on a permanent basis) The
KGB office in Berlin met a similar fate (it was supposed to be clandestine,
but oops-- intelligence agency installations are seldom hard to find because
they rely on being hidden in plain sight), however most of the files contained
within were destroyed thanks to the quick thinking of an officer there--
Vladimir Putin.

Another example of total victory is the ugly rout


on
HN today about how Bolivia had forced out the DEA. Sure, maybe you can argue
the DEA isn't the CIA or Mossad, but the point is clear: these organizations
can't operate with impunity if the (quasi stable) political apparatus decides
to resist them. An alternative set of examples here are
Iraq/Afghanistan/Pakistan/Kurdistan/Syria-- both the CIA and Mossad (and
likely Shin Bet) chalked big losses here (with heavy loss of life of their own
personnel as well as countless indigenous assets) because the population was
hostile to them. Collecting HUMINT requires willing humans, and torturing
people doesn't cause that. It's also extremely hard to blackmail or bribe a
tribesman.

3\. You can buy them out or co-opt them, if you have the right connections.
It's no secret that Putin rose to power via the KGB's influence, but during
the transformative 90s, Russia'seconomic power was privatized and separated
from the government's apparatus creating a plurality of power loci. Following
this, there began a curious phenomena (replicated by corollaries in the US
around the same time) of the Russian intelligence agencies being caught willy
nilly for industrial espionage. In the midst of economic strife and violent
internal insurgency in the Muslim territories around the same time period, the
intelligence agencies of Russia were largely busy chasing dollars rather than
mujaheddin. Why? Because the newly minted oligarchs were more concerned with
making more cash. This is currently happening in the US. The takeaway point
here is that a change in focus can count as a win.

4\. You can change their political mandate with reforms. The US has done this
once already with the CIA, and will likely do this many more times.


There are
too many examples of this to list.

~~~
TallGuyShort
So essentially, without obscene amounts of money and political power, I have
to be willing to commit treason and violently attack a government building?
Okay. So basically not something I'm going to achieve any time soon.

------
peterkelly
From page 3:

> _" NSA may access it only after demonstrating to the FISC that a 'reaonable
> articulable suspicion' that a particular phone number is associated with a
> foreign terrorist organization'"._

Shouldn't this say "associated with a foreign terrorist organisation, _or the
UN_ "?

[http://www.theguardian.com/world/2015/aug/17/un-att-nsa-
spy-...](http://www.theguardian.com/world/2015/aug/17/un-att-nsa-spy-
headquarters-privacy)

~~~
Roodgorf
I'm sure you could find a few people in the U.S. that would consider the U.N.
a foreign terrorist organisation.

~~~
sliverstorm
I know more than a few U.S. citizens who consider the U.S. Government a
foreign terrorist organization.

So yes, I believe you.

------
Floegipoky
Has anyone tried to use probability to cut through thismust allege
some threatened or actual injury resulting from the putatively illegal action
before a federal court may assume jurisdiction." LINDA R. S. v. RICHARD D.,
[http://caselaw.findlaw.com/us-supreme-
court/410/614.html#t4](http://caselaw.findlaw.com/us-supreme-
court/410/614.html#t4)

~~~
dragonwriter
> The prevailing judicial understanding, for more than 100 years, of the "Case
> and Controversy" clause has been that Article III courts can only hear
> lawsuits involving more-or-less concrete injuries.

Its important to understand the reasoning here: to wit, that if there isn't a
concrete, particularized, redressable injury -- where "injury" is understood
to be a violation of a legally-protected interest -- then there is no "Case"
to resolve.

The contentious part of this is primarily the "particularized" part, since
that requirement means that violations of the Constitutional limits of
government power do not give rise to a cause of action based solely on the
general citizens interest in constraining the government to


Cristiano Ronaldo, that doesn’t make the significance of Town’s upcoming investments any less.

With the names linked, it’s clear the club want to build on what made them so successful last season, rather than suddenly change direction.

By looking to add depth and increase the balance of the squad, Town aren’t just planning for now, but future proofing themselves.

The ‘star’ names getting larger wages and contract hikes will undoubtedly have relegation clauses inserted into deals so should the worst come to worse, the club is well placed to recover and challenge for an automatic return to the top-flight without spending a king’s ransom to do so.

Read More

There are models to emulate, clearly, with the likes of Southampton, Swansea City, AFC Bournemouth and Burnley having all grown into established Premier League
Most of the Google Walkout Organizers Have Left the Company - ChuckMcM
https://www.wired.com/story/most-google-walkout-organizers-left-company/
======
ChuckMcM
I have said it before that your best option when you discover the company you
work for no longer (or perhaps never did) shares your values about what is
right and what is wrong, you only have two choices; work from within to see if
the rank and file the same way and try to change it before you get fired, or
leave on your terms.

I found this comment in the story kind of ironic, _“I’m certain many in
leadership—who learned what Google was and why it was great over a decade
ago—don’t truly understand the direction in which Google is growing. Nor are
they incentivized to.”_

I don't know Meredith so I don't know how she reasoned to this statement but
my experience was that


has been circulating showing a man on the ground who appears to have canisters strapped to his body. The Guardian is not showing his face until his identity and connection to the incident have been established. Photograph: Gabriele Sciotto

Police arrest 12 people after raids

Following an operation in Barking, officers from the Met’s counter-terrorism command arrested 12 people in connection with the attack. They raided a block of flats shortly before midday on Sunday where at least one of the suspects is thought to have lived. Police also raided a flat above a betting shop on Barking Road in East Ham. Witnesses reported a heavy police presence and cordons near East Ham town hall.

Recent UK attacks

The London Bridge attack is the second attack in London and third attack indespite having felony charges in the last five years.

“These are policies that have been in place. They’re not policies that we just made up today because this happened,” Pastorick said. “These individuals understand the policies and how they operate, and how they need to be enforced. Through the investigation, it was determined the policies were not followed.”

Warden Tim Hooper ended Stagg’s detail as deputy warden of Elayn Hunt Correctional Center following the investigation, Pastorick said. He has been reassigned to his previous post as an assistant warden at Angola — a lower position on the prison operations organizational chart that includes a pay cut.

Major Jason Linzy also received a letter of counseling, Pastorick said, and additional training has been provided to staff regarding visitation policies.

The DOC investigator recommended


LONDON — The economic forecasts at the heart of Chancellor Philip Hammond's Budget speech are based on the assumption that annual net immigration to Britain will not drop below 100,000 once Britain leaves the European Union.

Hammond used his first budget to drive home the Conservative government's message that the national economy remains stable and resilient despite the uncertainty caused by Britain's vote to leave the European Union.

What Hammond didn't mention in his speech to MPs was that the Office for Budget Responsibility's projections were based on the assumption that Brexit will not reduce immigration to the extent that some pro-Leavers had hoped and predicted.

The key line can be found on page 33 of the OBR's 'Economic and fiscal outlook' under the sub-heading 'assumptions regarding the UK’s exit fromthe EU' — here it is:

The OBR add that their forecasts are based on the assumption that at most, immigration will fall to 185,000 by 2021.

Bringing net migration to the UK below 100,000 people a year was originally a pledge made by the Tories under former Prime Minister David Cameron in the run-up to the 2010 general election. The party decided to stick with the ambitious policy despite the obvious hurdle posed by the free movement of people within the European Union.

Net migration to the UK was 273,000 last year, according to the latest Office for National Statistics research.

One of the key reasons put forward by Brexit campaigners for why the country should leave the 28-nation bloc was that Britain could "take back control" of its borders and


 }
    }
}

Do bear in mind that this is not a finished script.

A:

Get the jQuery from window object
var $ = window.jQuery;

A:

I didn't find a better answer other than this.
In general, this chunk of code defines the library for further usage inside tampermonkey editor.
/*globals MY_LIB*/ using this will take off all warnings.
For more information check this (https://jshint.com/docs/#inline-configuration).
It explains what globals are, and how do they work.

answer from @Kailas, the way he posted is not the recommended way. Please, to everybody who read this: Think about the security of your application!
Although i already told and linked my detailed answer to the iOS 9 Ajax / ATS Problem, i'm going to do a fullquote here because of completeness.
So fullquote following - Original post over here
As far as i understood the whole ATS (App Transport Security - iOS 9) thing, the recommended method from area28 should not be the one you're using inside an application.
<key>NSAppTransportSecurity</key>
<dict>
    <key>NSAllowsArbitraryLoads</key><true/>
</dict>

This will allow all external requests to every domain what is definitively not the way you should use it. In my opinion you should define a new <dict> inside your info.plist and add this


of production of the newly renamed Warner Bros.-Seven Arts animation studio, and hired veterans such as Alex Lovy and LaVerne Harding from the Walter Lantz studio, Volus Jones and Ed Solomon from Disney, Jaime Diaz who later worked on The Fairly OddParents as director, and David Hanan, who previously worked on Roger Ramjet. Hendricks brought only three of the original Looney Tunes veterans to the studio; Ted Bonniscken, Norman McCabe and Bob Givens. The studio's one shot cartoons from this era were critically panned and are widely considered to be the worst in the  studio's history: Cool Cat, Merlin the Magic Mouse, Chimp and Zee and Norman Normal, despite the later gaining a large cult following, were said to be witless, crudely animated as well as havinganimation shorts

References

Sources
 Barrier, Michael (1999): Hollywood Cartoons. Oxford University Press.
 Maltin, Leonard (1987): Of Mice and Magic: A History of American Animated Cartoons. Penguin Books.
 Solomon, Charles (1994): The History of Animation: Enchanted Drawings''. Outlet Books Company.

Category:20th century in animation
Category:American animation
Category:Articles which contain graphical timelines
American animation
Category:History of animation


クエリのパラメタを設定する。
	''' <remarks>更新処理時のSET句で使用するパラメタを除く</remarks>
	Public Property PK_SupplierID() As Object
		Get
			Return Me.HtParameter("SupplierID")
		End Get
		Set
			Me.HtParameter("SupplierID") = value
		End Set
	End Property

	''' CompanyName列に対するパラメタ ライズド クエリのパラメタを設定する。
	''' <remarks>更新処理時のSET句で使用するパラメタを除く</remarks>
	Public Property CompanyName() As Object
		Get
			Return Me.HtParameter("CompanyName")
		End Get
		Set
			Me.HtParameter("CompanyName") = value
		End Set
	End Property

	''' ContactName列に対するパラメタ ライズド クエリのパラメタを設定する。
	''' <remarks>更新処理時のSET句で使用するパラメタを除く</remarks>
	Public Property ContactName() As Object
		Get
			Return Me.HtParameter("ContactName")
		End Get
		Set
			Me.HtParameter("ContactName") = value
		End Set
	End Property

	''' ContactTitle列に対するパラメタ ライズド クエリのパラメタを設定する。
	''' <remarks>更新処理時のSET句で使用するパラメタを除く</remarks>
	Public Property ContactTitle() As Object
		Get
			Return Me.HtParameter("ContactTitle")
		End Get
		Set
			Me.HtParameter("ContactTitle") = value
		End Set
	End Property

	''' Address列に対するパラメタ ライズド クエリのパラメタを設定する。
	''' <remarks>更新処理時のSET句で使用するパラメタを除く</remarks>
	Public Property Address() As Object
		Get
			Return Me.HtParameter("Address")
		End Get
		Set
			Me.HtParameter("Address") = value
		End Set
	End Property

	''' City列に対するパラメタ ライズド クエリのパラメタを設定する。
	''' <remarks>更新処理時のSET句で使用するパラメタを除く</remarks>
	Public Property City() As Object
		Get
			Return Me.HtParameter("City")
		End Get
		Set
			Me.HtParameter("City") = value
		End Set
	End Property

	''' Region列に対するパラメタ ライズド クエリのパラメタを設定する。
	''' <remarks>更新処理時のSET句で使用するパラメタを除く</remarks>
	Public Property Region() As Object
		Get
			Return Me.HtParameter("Region")
		End Get
		Set
			Me.HtParameter("Region") = value
		End Set
	End Property

	''' PostalCode列に対するパラメタ ライズド クエリのパラメタを設定する。
	''' <remarks>更新処理時のSET句で使用するパラメタを除く</remarks>
	Public Property PostalCode() As Object
		Get
			Return Me.HtParameter("PostalCode")
		End Get
		Set
			Me.HtParameter("PostalCode") = value
		End Set
	End Property

	''' Country列に対するパラメタ ライズド クエリのパラメタを設定する。
	''' <remarks>更新処理時のSET句で使用するパラメタを除く</remarks>
	Public Property Country() As Object
		Get
			Return Me.HtParameter("Country")
		End Get
		Set
			Me.HtParameter("Country") = value
		End Set
	End Property

	''' Phone列に対するパラメタ ライズド クエリのパラメタを設定する。
	''' <remarks>更新処理時のSET句で使用するパラメタを除く</remarks>
	PublicProperty Phone() As Object
		Get
			Return Me.HtParameter("Phone")
		End Get
		Set
			Me.HtParameter("Phone") = value
		End Set
	End Property

	''' Fax列に対するパラメタ ライズド クエリのパラメタを設定する。
	''' <remarks>更新処理時のSET句で使用するパラメタを除く</remarks>
	Public Property Fax() As Object
		Get
			Return Me.HtParameter("Fax")
		End Get
		Set
			Me.HtParameter("Fax") = value
		End Set
	End Property

	''' HomePage列に対するパラメタ ライズド クエリのパラメタを設定する。
	''' <remarks>更新処理時のSET句で使用するパラメタを除く</remarks>
	Public Property HomePage() As Object
		Get
			Return Me.HtParameter("HomePage")
		End Get
		Set
			Me.HtParameter("HomePage") = value
		End Set
	End Property

	''' Set_SupplierID_forUPD列に対するパラメタ ライズド クエリのパラメタを設定する。
	''' <remarks>更新処理時のSET句で使用するパラメタ専用</remarks>
	Public Property Set_SupplierID_forUPD() As Object
		Get
			Return Me.HtParameter("Set_SupplierID_forUPD")
		End Get
		Set
			Me.HtParameter("Set_SupplierID_forUPD") = value
		End Set
	End Property

	''' Set_CompanyName_forUPD列に対するパラメタ ライズド クエリのパラメタを設定する。
	''' <remarks>更新処理時のSET句で使用するパラメタ専用</remarks>
	Public Property Set_CompanyName_forUPD() As Object
		Get
			Return Me.HtParameter("Set_CompanyName_forUPD")
		End Get
		Set
			Me.HtParameter("Set_CompanyName_forUPD") = value
		End Set
	End Property

	''' Set_ContactName_forUPD列に対するパラメタ ライズド クエリのパラメタを設定する。
	''' <remarks>更新処理時のSET句で使用するパラメタ専用</remarks>
	Public Property Set_ContactName_forUPD() As Object
		Get
			Return Me.HtParameter("Set_ContactName_forUPD")
		End Get
		Set
			Me.HtParameter("Set_ContactName_forUPD") = value
		End Set
	End Property

	''' Set_ContactTitle_forUPD列に対するパラメタ ライズド クエリのパラメタを設定する。
	''' <remarks>更新処理時のSET句で使用するパラメタ専用</remarks>
	Public Property Set_ContactTitle_forUPD() As Object
		Get
			Return Me.HtParameter("Set_ContactTitle_forUPD")
		End Get
		Set
			Me.HtParameter("Set_ContactTitle_forUPD") = value
		End Set
	End Property

	''' Set_Address_forUPD列に対するパラメタ ライズド クエリのパラメタを設定する。
	''' <remarks>更新処理時のSET句で使用するパラメタ専用</remarks>
	Public Property Set_Address_forUPD() As Object
		Get
			Return Me.HtParameter("Set_Address_forUPD")
		End Get
		Set
			Me.HtParameter("Set_Address_forUPD") = value
		End Set
	End Property

	''' Set_City_forUPD列に対するパラメタ ライズド クエリのパラメタを設定する。
	''' <remarks>更新処理時のSET句で使用するパラメタ専用</remarks>
	Public Property Set_City_forUPD() As Object
		Get
			Return Me.HtParameter("Set_City_forUPD")
		End Get
		Set
			Me.HtParameter("Set_City_forUPD") = value
		End Set
	End Property

	''' Set_Region_forUPD列に対するパラメタ ライズド クエリのパラメタを設定する。
	''' <remarks>更新処理時のSET句で使用するパラメタ専用</remarks>
	Public Property Set_Region_forUPD()


callback();
    virtual void sync();
    virtual void init();
    void done();
    /* Todo: add access limitations */
    bool initialised;
    static DiskThreadsIOStrategy Instance;

private:
    static void aioStats(StoreEntry * sentry);
    void registerWithCacheManager(void);
};

#endif

find a bunch of missing resolutions which have been sent to Anisha to create the artwork for.

Async

Our DB load method used async but didn’t implement the conventions properly, so that has been changed to return a Task (I didn’t do that, but I am glad it was done) & renamed to have the async suffix on the name.

Category

For some reason we had an old category.cs file in our view models, so in v1 we named our view model categoryviewmodel.cs which bugged me. So removed old file, renamed & fixed class name. Hopefully makes it easier to navigate & also helps with another tasks I did below.

ViewModel Injection

One of the aspects in our MVVM implementation was that the view was responsible to load the correct view model it needed.


The invention relates to a method for applying a coating to a fiber by chemical vapor deposition (CVD).
Fiber reinforced ceramic matrix composites (CMCs) are formed of continuous uniaxial or woven fibers of ceramic material embedded in a ceramic matrix. These materials are designed to have a weak fiber-matrix bond strength so as to increase overall composite strength and toughness. When the CMC is loaded above a stress that initiates cracks in the matrix, the fibers debond from the matrix allowing fiber/matrix sliding without fiber fracture. The fibers can then bridge a matrix crack and transfer load to the surrounding matrix by transferring tensile stresses to frictional interfacial shear forces.
High temperature fiber reinforced CMCs have great potential for use in aircraft and gas turbine engines due to their highin a first run. The fiber tow is then removed from the deposition furnace and unwrapped from the support structure. The tow is then rewrapped onto the support structure, which is again loaded into the deposition furnace for a second run. This cycle is repeated several times for a thick coating. The unwrapping and rewrapping of the tow from the support structure is done to randomize contact points and tightly packed areas. The rewrapping method minimizes contact caused defects and non-uniformity caused by tight fiber packing. However, several coating runs are needed to adequately apply the fiber coating, thus reducing coating productivity and increasing coating costs.
Thus, there is a need to provide a method to coat the fibers of a wrapped tow in an efficient and effective manner.
The


invention relates to a method for applying a coating to reinforcing fibers arranged into a tow. The tow is aligned with an adjacent separation layer and wound onto a support structure in an interleaved manner so that the separation layer separates a wrap of the tow from an adjacent wrap of the tow. A coating can then be uniformly applied to the reinforcing fibers without defects caused by fiber tow to fiber tow contact. The separation layer can comprise a carbon fiber veil.
In another aspect, the invention relates to wrapping a support structure with alternating layers of separation layer and tow of reinforcing fibers in an interleaved manner so that each wrap of tow is separated from each other wrap of tow. A coating is then applied ontothe fibers of the tow in a chemical vapor deposition furnace.
Finally, the invention relates to a composition of matter, comprising a tow of reinforcing fibers and a separation layer with longitudinal axis in parallel alignment with a longitudinal axis of the tow. The tow and the separation layer are wound or wrapped together onto a support structure in an interleaved manner with the separation layer separating a wrap of the tow from an adjacent wrap of the tow.


of, a lender that is payday charge a fee between ten dollars and $30 for each and every $100 you borrow. If you’re taking out fully a $400 loan, you’ll roughly be paying $80 to borrow that money for only a couple of weeks. Now that is amazing exact same loan extended during a period of five months, that will be the normal period of time borrowers find yourself trapped with one of these simple financial loans.

Because of the payday that is average recharging between 400-1,200% yearly portion price (APR), that $80 in interest may become $1,600 or higher. Terrifying.

Danger sign 5: they need you to “roll over”

So that you took on a cash advance, along with your payment arrives but you don’t have actually the funds. Soengineer. As soon as you think you’re better than everyone else (you’re not) and stop learning, you start dropping in value. If no one’s reviewing your designs and code and telling you how very wrong you are, you’re never going to get lazy, just not the good kind of lazy.

Of course, taken to an extreme, any one of these attributes could make for a really bad engineer. The good engineers have just a little bit of each.

How about you, are you lazy? How about insecure? Know any paranoid friends? If so, I’ve got jobs for you. Consider it getting paid for your own therapy.


The invention relates to a field-device coupling unit for providing a supply voltage for a field device and for communication with a superordinate control unit, the field-device coupling unit comprising a current interface which is configured for communication with the control unit and has a first controllable input load which is configured to provide, from an interface current of the current interface, a load voltage on which the supply voltage is based, the field-device coupling unit further comprising a circuit arrangement for providing a communication signal to be transmitted to the control device.
A field-device coupling unit of the type described above is known from the prior art and is used to connect a field device to a superordinate control unit via a current interface.
The field-device coupling unit fulfilswere generally similar between the two groups ([Table I](#tbl1){ref-type="table"} ) except that the median age of the PEP group was significantly lower than that of the non-PEP group. None of these HCWs with high-risk exposure had worn an N95 respirator, isolation gown, goggles, or facial shield. The most common type of exposure to MERS-CoV was via direct care without aerosol-generating procedure for MERS-CoV patient (39.5%), followed by airway suction (39.5%) and nebulizer treatment (34.9%). Eighteen (41.9%) HCWs were only exposed to MERS-CoV via direct care without aerosol-generating procedure. Of these, 17 were in the non-PEP group and one was in the PEP group (*P* \< 0.001).Figure 1Study profile. MERS-CoV, Middle East respiratory syndrome coronavirus.Figure 1Table IClinical and demographic characteristics of healthcare workers in the prophylaxis and non-prophylaxis groupsTable ICharacteristicsTotal (*N* = 43)PEP group (*N* = 22)Non-PEP group (*N* = 21)*P*-valueAge (years),


break out. I wanted to do a comedy sketch that was quite controversial – it was all about prejudice and race and I was playing this mad, grotesque landlady. But the BBC didn't want me to do it – they said, 'It will ruin your image', which was basically a tizzy blonde. Anyway, I did it, but then I didn't work for them for years. They didn't like women who spoke up. But I don't like authority and I don't like being dictated to or told what to do."

Hancock and the BBC have long since made up, and she appeared in a number of recent productions including Bleak House, New Tricks and The Catherine Tate Show.

Born on the Isle of Wight to publican parents who moved to London,Hancock was introduced to the world of performing through the weekly piano singalongs that her parents hosted at their pubs.

"There were not many options for girls in those days," she recalls. "I was bright at school but I didn't know what university was – nobody did. So the options were being a nurse, a teacher, or an old maverick who went on to the stage. I did a school play and the head boy asked me out to a dance and I thought, 'This is good, I'll do this.' "

Her training at Rada was less to her taste. "I hated every minute. It was like a finishing school. I was a scholarship girl, I had an estuary accent, and everyone else was like Lord this, or the Hon


and takes selfies.

Production

Development
Speaking in an interview with the Manchester Evening News in 2016, Richard Thomas, the creator of the Oddbods and creative director at One Animation described how he first devised the show:

One Animation
Founded in 2008, One Animation is a CGI animation studio based in Singapore, which also produced Rob the Robot, The Insectibles and Development Series (Hard Boiled and Abigail's Tales). The company has produced a portfolio of successful animated series that are broadcast on global networks such as Disney Channel, Cartoon Network, Nickelodeon, Disney XD, Discovery Kids, ABC, and seen across more than 100 countries worldwide.

The company focuses on developing family-focused TV, film and new media content, facilitating shorter than average production schedules, utilizing a crew that is typically one-third the size of a traditional CGIPorno King

Sex = Female
Where it happened = In House
Language = English
Refnum = 13633

I am Lim Chin Ping.I want to relate a story about me and my fiancee Hwei Ching....This happened when CP bumped into HC.Once they saw each other,the fell in love.....After several weeks of flirting,CP decided to masturbade with HC...She agreedSo one on Friday night,HC invited CP to her house for asusual the late show.CP agreed and went to her house sharp at 10pm.After he arrived,HC was so excited so she asked CP whether he wants to ...(u know lahh)He said goodddd....He can't believe that this his happening.His dreams finally came true..Once HC stripped naked,CP's dick started to stim(sorree wrong spelling).HC went to CP and unzipped his Kikilala jeans.She continued to pull down his underwear.So she started


under the terms of the GNU General Public License as published by
    the Free Software Foundation, either version 3 of the License, or
    (at your option) any later version.

    OpenFOAM is distributed in the hope that it will be useful, but WITHOUT
    ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or
    FITNESS FOR A PARTICULAR PURPOSE.  See the GNU General Public License
    for more details.

    You should have received a copy of the GNU General Public License
    along with OpenFOAM.  If not, see <http://www.gnu.org/licenses/>.

InNamespace
    Foam::fvc

Description
    Reconstruct volField from a face flux field.

SourceFiles
   OS.Path.concat(p,rest)
            end
        end
    else modPath
  end

infix ++
fun p1 ++ p2 = OS.Path.concat(p1,p2)

fun check_insert(m,k,v) =
  let
    val _ =
        case Binarymap.peek(m,k) of
            NONE => ()
          | SOME v' => if v' <> v then
                         warn((v ++ ".holpath") ^ " overrides value for "^


                    k ^ " from " ^ (v' ++ ".holpath"))
                       else ()
  in
    Binarymap.insert(m,k,v)
  end

fun readVName d m =
  let
    val hp = d ++ ".holpath"
    val istrm = TextIO.openIn hp
    val m' =
        case TextIO.inputLine istrm of
            NONE => (warn (hp ^ " is empty"); m)
       in the interest of justice. As an alternative holding, we also reject it on the merits.
THIS CONSTITUTES THE DECISION AND ORDER
OF THE SUPREME COURT, APPELLATE DIVISION, FIRST DEPARTMENT.
ENTERED: DECEMBER 22, 2016
DEPUTY CLERK


Mark:

Please review the attached Credit Schedule from Dow.  Given that our trade
flow with them has increased to date and is expected to further accelerate, I
agree with you totally that we need to finalise the ISDA.

Doug
---------------------- Forwarded by Douglas S Friedman/HOU/ECT on 02/23/2001
04:14 AM ---------------------------

"Corbett, Cheryl (CE)" <CECORBETT@dow.com> on 02/22/2001 07:11:13 AM
To: "'Douglas.S.Friedman@enron.com'" <Douglas.S.Friedman@enron.com>
cc: "Antuna, Luis (L)" <LAntuna@dow.com>
Subject: FW: ISDA TDCC/Enron

Doug, attached for your review and comment is the draft ISDA Schedule we
recently forwarded to Adam Gross.  Please forward any comments directly to
Luis Antuna at lantuna@dow.com or by telephone at 517-638-6789.

Regards,

Cheryl Corbett

>  -----Original Message-----
> From:  Antuna, Luis (L)
> Sent: Friday, February 09, 2001 11:59 AM
> To: 'agross@enron.com'
> Cc: Billings, Mike (ME); Corbett, Cheryl (CE)
> Subject: ISDA TDCC/Enron
>
> Mike Billings has given    \path[every node/.style={font=\sffamily\small}]
        (x) edge[->] node {} (y);
    \end{tikzpicture}
}
\end{figure}

A:

Use fill=white.
\documentclass{article}
\usepackage{tikz}
\begin{document}
  \begin{figure}
\centering
    \begin{tikzpicture}[transform shape,mylabel/.style={thin, draw=black, align=center, minimum width=0.5cm, minimum height=0.5cm,fill=white,font=\Large}]
        \newcommand\XA{-3}
        \newcommand\YA{0}
        \node (x) [circle, draw=black, align=center, minimum size=1cm] at (\XA,\YA) {$V$};
        \node (y) [circle, draw=black, align=center, minimum size=1cm   ] at (\XA-1.5,\YA-1.5) {$U$};
        \draw[->]  (x) -- node[mylabel] {d} (y);
    \end{tikzpicture}
\end{figure}
\end{document}

\centering doesn't take an argument, hence {...} are not needed. Also, edge is a monster, don't use it for small things.


office in 1960. “I had no idea what they wanted with me,” said Howard who was about to finish a law degree. He took exams, filled out an application in May and on July 1, 1960, was sworn in.Howard vividly remembered his first assignment just 10 days on the job. Because no one would recognize him he was put undercover to help catch a counterfeiter, which they did in just three days, red-handed with cash and printing plates in his possession.We then jumped ahead to the weekend of Nov. 21-22, 1963, for his memories of that fateful Kennedy visit. The Democratic Party had scheduled five stops in Texas for that weekend, which included an overnight stop in Fort Worth on Nov. 21. At approximately 11 p.m. that nightShare This Page

KORAT ROYAL THAI AIR FORCE BASE, Thailand (AFNS) -- Readiness and continued development of multilateral interoperability remains a key priority for Indo-Asia-Pacific partners participating in the 22nd year of exercise Cope Tiger, a joint multilateral field training exercise that began March 7 at Korat Royal Thai Air Force Base.

During the two-week exercise, more than 1,200 combined service members and civilians from the U.S., Thailand and Republic of Singapore aim to enhance cooperative relationships and improve procedures in airpower.

“Cope Tiger 16 is a great experience for our Airmen, building upon the exercise’s 22 year history, to deepen relationships with two key Indo-Asia-Pacific partner nations and to reinforce our combined airpower interoperability,” said Lt. Col. Jack Arthaud, the exercise director for the U.S. Air Force. “The flying exercise


Rising income inequality, and the resulting scarcity of certain types of jobs, is a key reason a growing number of young Americans are having babies before getting married.

A study led by Johns Hopkins University sociologist Andrew J. Cherlin is the first to trace how the income gap, a large-scale societal trend, affects individual personal choices about starting a family. The greater the income inequality in an area, the less likely young men and women are to marry before having a first child, according to the study, which is published online today and will appear in the August issue of the American Sociological Review.

"Does income inequality affect a young adult's decision about getting married and starting a family?" asked Cherlin, the Benjamin H. Griswold III Professor of Public PolicyAutocrine action of IL-10 suppresses proinflammatory mediators and inflammation in the HSV-1-infected cornea.
We investigated whether IL-10 produced endogenously would influence the development of HSV-1-induced acute corneal disease. Murine corneal epithelial cells and fibroblasts cultured in vitro expressed IL-10 mRNA and protein constitutively and also IL-10 receptors. Inclusion of IL-10 neutralizing antibody in the culture medium significantly (p<0.05) enhanced TNF-alpha-induced IL-6 and MIP-2 production by both corneal cell types. Endogenous IL-10 synthesis, which also occurred in vivo, was not modulated by Herpes virus infection or by depletion of neutrophils or natural killer cells. Antibody to IL-10 given locally at the time of HSV-1 intracorneal infection was associated with significantly (p<0.05) enhanced production of IL-6, MIP-2, and MIP-1alpha, increased neutrophil infiltration, and more extensive corneal disease. Similarly, mice with a


he never acted as Foreman’s personal lawyer. Cotter retained and utilized

his own lawyers for his personal negotiations to individually purchase the assets of the

Washington division.

       {¶ 5} In his deposition, Koverman testified that, at the buyer’s request, the broker

did not initially disclose the identity of the potential buyer, but that Cotter and Anthony
                                                                     2) that Koverman acted with malice; and 3) that their injuries were not in

common with the other shareholder.

       {¶ 17} The trial court sustained the motion for summary judgment in part, and

overruled it in part. The trial court considered all claims in the complaint to constitute an

action for legal malpractice. The trial court held that Cotter and Anthony could not pursue


                                                -14-

did not vote to pursue the lawsuit, and the claim was not properly brought as a

shareholders’ derivative action, and (4) the statute of limitation for legal malpractice has

run. The trial court determined that: (1) the plaintiffs’ only claims are for legal malpractice,

(2) the individual plaintiffs had no attorney-client relationship with the defendants, and no

substitute (privity, malice, or uncommon injury) for an attorney-client relationship, (3) that

the corporations have authority to pursue the action and, therefore, it was unnecessary

for the claim tobetween mother and child, a commonality of interest in

getting the child support, was a substitute for an attorney-client relationship. Scholler cited

the general privity principle, but the finding of no privity in Scholler demonstrates how very

narrow the privity exception is interpreted. Scholler held that “an attorney who represents

a spouse in the negotiation of a separation agreement does not simultaneously,

automatically represent the interests of a minor child of the marriage.” Id at 104. In other

words, there is no privity between mother and child.

       {¶ 25} The next often cited case in the “privity” sequence is Simon v. Zipperstein,

32 Ohio St.3d 74, 77, 512 N.E.2d 636 (1987). There the attorney had drafted both an

antenuptial agreement and a will for a client. The documents could be


construed as

inconsistent. After the client’s death, one of the potential beneficiaries under the will

brought an action against the attorney for malpractice because the attorney did not clearly

prevent the surviving spouse from taking under both the antenuptial agreement and the

will. The trial court had granted a motion for summary judgment for the attorney,

concluding that absent privity, the potential heir did not have standing to sue the attorney.

This court reversed. But the Ohio Supreme Court then reversed this court. It concluded

that a potential beneficiary of a will was not in privity with the testator for purposes of suing

the attorney who prepared the will. It also cautioned this court about disregarding the

holding of Scholler based upon non-distinct “public policy” grounds. Simon therefore also

reflects how very narrow the privity exception is whenvested

beneficiary for damages arising from the attorney's negligent performance.” Id. at 177.

There is a question whether the Supreme Court’s distinction between Elam and Simon,

that the affected heirs were vested in Elam but not in Simon, was factually supported. But

there is a clear distinction between the cases. In Elam, the failure to correctly distribute

the real estate in part to the surviving spouse and in part to the remaindermen was an

undisputed error in the transactional process of completing the estate by the attorney. In

Simon, the alleged error is distinguishable because the manner of how, and to whom, the

estate would be distributed was at issue, an error alleged to have been caused by the

attorney, who had represented the decedent before his death. At the time of the

decedent’s representation by the attorney,


case we believe once the defense demonstrates a lack of an

attorney-client relationship, the burden falls to plaintiffs to demonstrate malice as an
                                                                               -20-

exception. The first element of a legal-malpractice case is that there exists an attorney-

client relationship. Defendant Koverman’s affidavitstates: “I never represented Michael

Cotter and Al Anthony.” (Koverman Affidavit ¶ 5). There is no evidence to the contrary.

We conclude this is sufficient to place the burden on the plaintiffs to demonstrate an

exception to the general rule, or at least that there is a genuine issue of material fact as

to whether an exception exists, and therefore the plaintiffs had the burden of presenting

evidence that malice substituted for the lack of an attorney-client relationship.

       {¶ 31} The previously-addressed cases of Scholler, Simon, and Arpadi, by

quotation of Scholler, all pay lip-service to the concept that an attorney who acts

maliciously may be sued for malpractice by a non-client, but there is little Ohio case law

identifying what set of facts is necessary to constitute malice as


a substitute for an

attorney-client relationship. Both parties cite the ordinary definition of malice that has

been developed and used to determine whether punitive damages are recoverable.

“Malice” means “(1) that state of mind under which a person’s conduct is characterized

by hatred, ill will or a spirit of revenge, or (2) a conscious disregard for the rights and

safety of other persons that has a great probability of causing substantial harm.” Preston

v. Murty, 32 Ohio St.3d 334, 336, 512 N.E.2d 1174 (1987). Both appellants’ merit and

reply brief highlight the second part of the definition about a “conscious disregard,”

apparently recognizing that evidence of hatred, ill will, and revenge is lacking here.

Indeed, a review of the materials submitted for the Civ.R. 56 motion fails to demonstrate

a genuine issue that any of these elements exist.as it did here. To hold otherwise would mean no attorney could advise a

client about, or legally participate in, the freeze out of a minority shareholder without

incurring malpractice liability. But that is not the law. Ohio has not recognized a direct

cause of action against an attorney who represents an entity in a freeze out by the minority

who lost in an internal dispute. Other states that have recognized a claim directly against

attorneys who assisted a business freeze out have done so on a breach-of-fiduciary-duty

theory. See, e.g., Fassihi v. Sommers, Schwartz, Silver, Schwartz & Tyler, P.C., 107 Mich.

App. 509, 514, 309 N.W.2d 645 (Mich. App. 1981). But as previously stated, in Ohio, a

claim against an attorney acting in his professional capacity is a malpractice claim. Ohio

does not recognize an independent


June

26, 2012 at 226). When Cotter was pressed further on the issue of malice, the following

exchange took place:

       Q. -- but do you have evidence, other than your opinion that they did not

       act in your best interest, do you have evidence that Mr. Koverman, Mr.

       Smith, or the entity Koverman & Smith as it's been named in the complaint

       actually had a vendetta against you and acted with disregard to your rights

       or otherwise with malice or with an intent to harm you?

       A.   I -- not that Iany third party to whom the fiduciary owes

fiduciary obligations.”    Ohio does not have a separate statute for closely held

corporations.

       {¶ 56} Implicit in the holding of Fornshell is the recognition that public policy has

changed with regard to the relationship between entities and persons providing services

to entities, who are now considered not in privity with the entity or individual members of

that entity, unless a written agreement expressly establishes privity. It is not clear whether


Sacksteder v. Senny, 2d Dist. Montgomery No. 24993,

2012-Ohio-4452 (malpractice action dismissed against corporate lawyer for participating

in breach of fiduciary duty). Therefore, I conclude that currently Ohio does not recognize

a cause of action against corporate attorneys for negligent conduct that aids and abets

their corporate client in breaching the client’s fiduciary duty to minority shareholders in a

closely held corporation.    This does not create immunity from liability for corporate

counsel for a closely held corporation for his own conduct constituting a breach of duty, if

that duty is owed directly to the minority shareholders.

       {¶ 60} What duty is owed directly to minority shareholders by the attorney for a

closely held corporation has not been addressed by any court in Ohio. Prior to the

statutory changes                                                                                -43-

incurring liability. But if the lawyer does as Koverman claims to have done in this case –

correctly advises his client of its duties to minority shareholders – but the client acts

contrary to its lawyer’s advice, then there would be no basis


 4) Koverman acted for Foreman in negotiating the sale, without input

from Cotter, and directed the course of the shareholders meeting, without

allowing consideration of Cotter’s offer, thereby diminishing the value of the

legal services for which the company overpaid Koverman the sum of

$50,000.

       5) Koverman’s conduct contributed to the company’s failure to

accept Cotter’s offer and end the deal, which caused the company to incur

unnecessary attorney fees for many years, and caused Cotter to incur

$150,000 in legal fees.

       6) Koverman’s conduct in directing the company to make the sale

with Morgan directly caused a loss of value to his stock, as a minority

shareholder of Omega.

       7) Koverman failed to stop the sale, anddeposition, reveal numerous issues of material fact. Viewing the evidence in a

light most favorable to Cotter, the disputed facts from which a trier of fact could infer that

Koverman acted with malice include:

              1) Koverman, individually, or in concert with Foreman, took no action

       to assure that all pertinent financial records and pending offers were timely

       provided to Cotter, with the knowledge that Cotter could not submit a

       competitive offer without the information.

              2) Koverman, individually, or in concert with Foreman, failed to


or auction the assets to a third party in order to close the Washington

division, thereby foreclosing any opportunity for Cotter to continue the

business in Washington.

       6) Koverman, individually, or in concert with Foreman, negotiated a

non-compete agreement with the buyer of the Washington assets that

would have the effect of blocking Cotter from continuing his work in

Washington, causing Cotter to lose his corporate benefits and his job in the

company.

       7) Koverman misrepresented that the name of the buyer could not
                                      be   considered   if   it   contained   financing   contingencies,   and

       misrepresented the urgency of accepting the offer based on the expiration

       of the warehouse lease, which had, in fact, been extended.

       {¶ 72} All of these factual disputes present genuine issues of material fact

whether Koverman consciously disregarded Cotter and Anthony’s rights, and was aware

that his actions had a great probability of causing substantial harm. Therefore, the trial

court erred by finding that Koverman was entitled to summary judgment on the tort claim

alleging malice or bad faith.

             V.


plan---as well as how that choice affects the health plan market---is thus increasingly important. At issue is whether individuals are indeed able to obtain and fully evaluate the information available to them and make a choice that is appropriate to their situation. Without these "appropriate" selections by consumers, choice will not lead to better individual or market outcomes.

The purpose of this article is to add to the existing empirical work on choice of health plan by examining (1) the reasons why low-income persons choose a managed care plan and (2) the effects of choice of plan on access to health care services and satisfaction with care. It is particularly important to have this sort of empirical information pertaining to low-income populations. This knowledge may be useful to thosewith choice are more likely to work for larger firms. To the extent that there are systematic differences between those who work for large and small firms and that these differences affect the relationship between choice and access/satisfaction, our results may be biased. Given the similarities observed among the groups and the homogeneity in terms of income, we would not expect these biases to be large.

Our findings indicate that, with respect to satisfaction, choice appears to have a more consistent effect for Medicaid enrollees than for the privately insured. This may be, in part, attributable to our classification of who has "no choice." For the privately insured, the "no choice" variable comprises primarily persons whose employers have made only one plan available. For the Medicaid population, the "no


 Age Under 30 Years          [\*\*\*](#tfn14-hcfr-20-1-029){ref-type="table-fn"}0.36   [\*\*\*](#tfn14-hcfr-20-1-029){ref-type="table-fn"}0.49   NS                                                        [\*\*](#tfn13-hcfr-20-1-029){ref-type="table-fn"}2.10     [\*\*\*](#tfn14-hcfr-20-1-029){ref-type="table-fn"}2.36   [\*\*\*](#tfn14-hcfr-20-1-029){ref-type="table-fn"}1.72   NS                                        Several telescopic discovery
programs are actively searching for these large NEO's, and the discovery
rate is increasing. However, Chodas believes, it may be at least 10 years
before 90 percent of the total population is revealed.

A new analysis by Rabinowitz shows that there may be only half as many
large hazardous objects as previously estimated. Harris will present new
evidence to refute a controversial theory that the Earth is continually
bombarded by a population of house-sized comets.

What is the nature of these seemingly "loose cannons" that might be posing
a threat? A new view has evolved, suggesting that many large asteroids
are "rubble-piles," according to William Bottke, a research associate in
Cornell's Department of Astronomy, who will moderate the press session
(Friday, July 30, 10 a.m., Princeton-Yale Room, Statler Hotel) on asteroid
moons and spins. Other participants will include


organoids.^\*^*P* ≤ 0.05. ^\*\*^*P* ≤ 0.01. ^\*\*\*^*P* ≤ 0.001. ^\*\*\*\*^*P* ≤ 0.0001. (**F**) The expression and subcellular localization of β-catenin in primary cell organoids (BCa \#04) treated with DMSO or 10 µM CHIR for 72 hours was detected by immunofluorescence staining. Nuclei and actin fibers were counterstained with DAPI and ActinRed, respectively. Scale bar 20 µm.](oncotarget-09-11060-g003){#F3}

We also investigated status of Wnt/β-catenin pathway in primary organoids treated with CHIR. AXIN2 expression did not change over time with DMSO treatment but was significantly upregulated with CHIR treatment in primary organoids prepared from BCa \#04 (Figure [3D](#F3){ref-type="fig"}). Analysis of 3 pooled patient samples confirmed upregulation of AXIN2 expression with CHIR treatment in primary organoids (Figure [3E](#F3){ref-type="fig"}). Whole mount staining of organoids demonstrated increased expression of β-catenin in cytoplasm and translocation ofof β-catenin in RT4 and 5637 transiently transfected with siRNAs against β-catenin. Protein was extracted 48 hours after transfection. GAPDH was used as a loading control. NC, negative control. (**B**) RT4 was transiently transfected with siRNAs and used to generate organoids. Images show representative RT4-derived organoids after transfection at day 1 and 6. Scale bar, 100 µm. (**C**) Relative growth of RT4-derived organoids after transfection was quantified and plotted. (**E**) 5637 was transiently transfected with siRNAs and used to generate organoids. The organoids were subsequently treated with 2.5 µM of CHIR. Images show representative 5637-derived organoids after transfection and treatment at day 1 and 5. Scale bar, 100 µm. (**F**) Relative growth of 5637-derived organoids after transfection and treatment was quantified and plotted. Each dot represents relative growth


in RT4 than 5637, while basal markers, CK14 and CK5, were more in 5637 than RT4 (Figure [5A](#F5){ref-type="fig"}). The result was in line with the finding that RT4 and 5637 were luminal and basal phenotypes, respectively \[[@R32]\]. CK20, CK18, and CK14 were significantly less expressed in CHIR-treated RT4-derived organoids than DMSO-treated controls, while all 4 genes examined remained unchanged in 5637-derived organoids (Figure [5A](#F5){ref-type="fig"}). Western blotting analysis also showed that CK20 was detectable in RT4 but not in 5637, and CK5 was in 5637 but not in RT4 (Figure [5B](#F5){ref-type="fig"}). CK20 was expressed at lower levels at the protein level in CHIR-treated RT4-derived organoids as compared to DMSO-treated controls (Figure [5B](#F5){ref-type="fig"}). qPCR revealed that CK20 was expressed at lower levels in CHIR-treated primary organoids as well (Figure [5C,experiments using an appropriate model based on our hypothesis to further understand a role of Wnt/β-catenin pathway in bladder tumor.

In conclusion, we showed for the first time that Wnt/β-catenin pathway was directly involved in proliferation of bladder cancer cells by using organoid culture, which could not be found in conventional adherent culture. Different responses of cancer cells to CHIR between organoid and adherent culture underscores importance of organoid culture for drug screening *in vitro*. The Wnt/β-catenin pathway may be a potential target for the treatment of a subset of bladder cancer.

MATERIALS AND METHODS {#s4}
=====================

Ethics statement {#s4_1}
----------------

The institutional review board at the Johns Hopkins School of Medicine approved the protocol for the research use of human bladder cancer specimens surgically resected from patients. Patients gave written informed consent for


assay, generation of organoids, and growth assay 48 hours after transfection.

Statistical analysis {#s4_8}
--------------------

Statistical analysis was conducted using GraphPad Prism 7 (GraphPad Software, San Diego, CA, USA). Differences among multiple groups were compared by analysis of variance (ANOVA) followed by a Tukey's multiple comparisons test. Two-group analysis was performed by unpaired *t*-test. A value of *p* \< 0.05 was considered statistically significant.

SUPPLEMENTARY MATERIALS FIGURES {#s5}
===============================

We would like to thank Dr. Masahiro Inoue (Department of Biochemistry, Osaka International Cancer Institute) for his intellectual contributions to this study.

**CONFLICTS OF INTEREST**

The authors have no conflicts of interest.

**FUNDING**

The Greenberg Bladder Cancer Institute Research Grant and the Urology Care Foundation.

**Editorial note**

This paper has been accepted based in part on peer-review conducted by another journal and the authors' response and revisions as well as expeditedaccount of events there. Bede states that after the synod, and the return of Roman customs, James, as a trained singing master in the Roman and Kentish style, taught many people plainsong or Gregorian chant in the Roman manner.

James' date of death is unknown, but Bede implies that he was still alive during Bede's lifetime, which presumably means that he died after Bede's birth, sometime around 671 or 672. This would mean that he was at least 70 years old at his death. It has been suggested that James was Bede's informant for the life of Edwin, the works of Paulinus, and perhaps for the Synod of Whitby. The historian Frank Stenton calls James "the one heroic figure in the Roman mission". This reflects the fact that many


question.

Several deaths following past hurricanes have occurred due to fires. In many cases, fires were caused by the careless use of candles to light homes without electrical power.

Use battery-powered lanterns, if possible, rather than candles. If you use candles, make sure they are in safe holders away from curtains, paper, wood or other flammable items. Never leave a candle burning when you are out of the room.

DOWNED POWER LINES

If power lines are lying on the ground or dangling near the ground, do not touch the lines.

Notify your utility company as soon as possible that the lines have been damaged or that the power lines are down.

Do not attempt to move or repair the power lines.

DRIVING THROUGH FLOODS

Do not drive through standing water if downed power lines are into mitigate the underlying losses and less favorable access to credit lines, in our view,” S&P Global Ratings said in a statement last week.

Sources close to the company and investors have said the business remains hemmed in by financing constraints - a major issue for trading houses - and has lost many traders, analysts and managers over the past months, despite cash offers to keep key staff until December.

Noble’s shares were 12 percent higher in late morning trade while its 2020 bonds were up about three points at 36.5/37.5 cents on the dollar.

The shares are down 75 percent this year, shrinking its market value to around $400 million, compared with $6 billion in February 2015.

Noble was thrust into the spotlight in February 2015 when previously obscure Iceberg Research


devices such as thin film transistors (TFT), have now become generalized, and the molded articles produced from the compositions comprising polycarbonate resins incorporated with a white pigment such as titanium oxide are being used for the light reflectors used in such devices.
Japanese Patent Application Laid-Open (KOKAI) No. 9-12853 proposes a polycarbonate resin composition with high light reflectance comprising (A) a polycarbonate resin, (B) titanium oxide, (C) a composite rubber-based graft polymer produced by graft polymerizing one or more vinyl monomers with a composite rubber having a structure in which a polyorganosiloxane rubber and an alkyl poly(meth)acrylate are inseparably entangled with each other, (D) a flame retardant and (E) polytetrafluoroethylene. This resin composition, however, involves the problems such as corrosive action to the cylinder, screw and mold of theby weight of an aromatic polycarbonate resin (a), 3 to 30 parts by weight of titanium oxide (b), 0.01 to 9 parts by weight of silica (c1), 0.01 to 9 parts by weight of a polyorganosiloxane polymer (c2), and 0.01 to 5 parts by weight of polytetrafluoroethylene (d).
In the second aspect of the present invention, there are provided the molded articles comprising the polycarbonate resin composition as defined in the first aspect.
The invention is described in detail below.
The aromatic polycarbonate resin (a) used in the present invention is a thermoplastic aromatic polycarbonate polymer or copolymer which may be branched and can be produced by reacting an aromatic hydroxyl compound and/or a small quantity of a polyhydroxyl compound with phosgene or a carbonic acid diester. The method of producing


dihydroxyl compounds. Examples of such substitute compounds include polyhydroxyl compounds such as fluoroglucin, 4,6-dimethyl-2,4,6-tri(4-hydroxyphenyl)-2-heptene, 4,6-dimethyl-2,4,6-tri(4-hydroxyphenyl)heptane, 2,6-dimethyl-2,4,6-tri(4-hydroxypheyl)-3-heptene and 1,3,5-tri(4-hydroxyphenyl)benzene; 1,1,1-tri(4-hydroxyphenyl)ethane, 3,3-bis(4-hydroxydiaryl)oxyindole (=isatinbisphenol), 5-chloroisatin, 5,7-dichloroisatin, and 5-bromoisatin. These compounds are usually used in an amount of 0.01 to 10 mol %, preferably 0.1 to 2 mol %.
The particularly preferred aromatic polycarbonate resins for use in the present invention are the aromatic polycarbonate resins derived from 2,2-bis(4-hydroxyphenyl)propane and the polycarbonate polymers derived from 2,2-bis(4-hydroxyphenyl)propane and other aromatic dihydroxyl compounds. In the course of preparation of the aromatic polycarbonate resin, a polymer or an oligomer having a siloxane structure may be copolymerized for further improving flame retardancy of the produced polycarbonate resin composition. The aromatic polycarbonate resin used in the present invention may be a mixture of two or more types ofany specific restrictions regarding its production method, crystal structure and average particle size. There are two types of production method of titanium oxide (b): (1) sulfuric acid method and (2) chlorine method. When titanium oxide produced by the sulfuric acid method is used, the produced composition tends to deteriorate in whiteness, so that titanium oxide produced by the chlorine method is preferably used for the effective attainment of the object of the present invention.
The crystal structure of titanium oxide may be either rutile type or anatase type, but rutile type is preferred in view of light resistance. The average particle size of titanium oxide is usually 0.1 to 0.7 xcexcm, preferably 0.1 to 0.4 xcexcm. When the average particle size is less than 0.1 xcexcm, the molded article


salt of an alkali metal or an alkaline earth metal such as sodium, lithium, potassium, rubidium, cesium, beryllium, magnesium, calcium, strontium and barium.
Preferred examples of perfluoroalkanesulfonic acid metal salts (g1) are alkali metal salts of sulfonic acid having C1-C8 perfluoroalkane groups, and alkaline earth metal salts of sulfonic acid having C1-C8 perfluoroalkane groups. More specific examples of such sulfonic acids are perfluoromethanesulfonic acid, perfluoroethanesulfonic acid, perfluoropropanesulfonic acid, perfluorobutanesulfonic acid, perfluoropentanesulfonic acid, perfluorohexanesulfonic acid, and perfluorooctanesulfonic acid.
As aromatic sulfonic acid metal salt (g2), there can be used, for instance, aromatic sulfonesulfonic acid alkali metal salts and aromatic sulfonesulfonic acid alkaline earth metal salts. These metal salts may be polymers. Examples of aromatic sulfonesulfonic acid metal salts include sodium salt of diphenylsulfone-3-sulfonic acid, potassium salt of diphenylsulfone-3-sulfonic acid, sodium saltfor some reason
*/

function not_in_blocked_country() {
  const customize = redux.getStore("customize");
  if (customize == null) return true; // don't know
  const country = customize.get("country");
  if (country == null) return true;
  const nonfree_countries = customize.get("nonfree_countries");
  if (nonfree_countries == null) return true;
  return !nonfree_countries.contains(country);
}

export function too_many_free_projects(): boolean {
  // there are never too many free projects if we're NOT on cocalc.com
  if (not_in_blocked_country()) return false;

  const running_projects =
    redux.getStore("server_stats")?.getIn(["running_projects", "free"]) ?? 0;
  // limit of 0 means it is disabled.
  const free_limit =
    redux.getStore("customize")?.get("max_trial_projects") ?? 0;

  return free_limit > 0 && running_projects >= free_limit;
}

export function allow_project_to_run(project_id: string): boolean {
  function log(..._args) {
    //console.log("allow_project_to_run", ..._args);
  }
  if (not_in_blocked_country())


     url: pathservicehost + '/file',
        contentType: 'application/pdf',
        success: function (data) {
            console.log('ok');
            var blob = new Blob([data], { type: 'application/pdf' });
            var link = document.createElement('a');
            link.href = window.URL.createObjectURL(blob);
            link.download = "report.pdf";
            link.click();
base 4
3
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-55
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33
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1
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-65
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-8
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-23
27 (base 9) to base 7
34
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-44
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6
-149 (base 12) to base 2
-11001001
Convert 2 (base 3) to base 5.
2
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-2
What is -1101100 (base 2) in base 16?
-6c
Convert 10 (base 7) to base 15.
7
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-8
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3
-2022 (base 3) to base 9
-68
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1
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-4
37 (base 11) to base 2
101000
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9) to base 6
-1
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3
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2
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1045
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77
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1
What is -3 (base 15) in base 10?
-3
What is 1 (base 12) in base 2?
1
Convert 11110001 (base 2) to base 12.
181
120 (base 8) to base 11
73
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20a
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1010
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-121
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2000
6 (base 10) to base 7
6
110 (base 5) to base 4
132
Convert 4 (base 11) to base 12.
4
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-1
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3
What is 2 (base 5) in base 9?
2
-87 (base 15) to base 2
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3 (baseis -34 (base 7) in base 13?
-1c
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-223
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0
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0
505 (base 8) to base 5
2300
-2 (base 4) to base 9
-2
-4 (base 10) to base 7
-4
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2d
-102 (base 7) to base 14
-39
25 (base 6) to base 11
16
What is -200 (base 3) in base 16?
-12
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7
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204
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-26
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-2
What is 11 (base 4) in base 16?
5
What is -10 (base 2) in base 7?
-2
100001 (base 2) to base 12
29
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1052
-2 (base 3) to base 11
-2
11 (base 6) to base 9
7
Convert -1035 (base 6) to


Capturing the Northern Lights - tfordifference
http://www.travelfordifference.com/capturing-northern-lights/
======
anon1253
On the very rare occasion I get to photograph the Northern lights in the
Netherlands [1]. Conditions have to be just right, and you can almost never
make it out with the naked eye. But the camera does wonders.

A couple of tips:

\- Avoid the full moon, it's not worth doing it unless the Aurora is strong
and you're in Iceland or something [5]

\- Watch the NOAA satellites [2,6]

\- Under moderate light pollution a CLS or UHC filter can help, they make
clip-on ones for Canon and Nikon [3,4]. Although nothing beats dark skies.

[1]:
[https://www.flickr.com/photos/joelkuiper/albums/721576649734...](https://www.flickr.com/photos/joelkuiper/albums/72157664973497160)

[2]:
[https://twitter.com/JoelKuiper/lists/aurora](https://twitter.com/JoelKuiper/lists/aurora)

[3]: [http://www.astronomik.com/en/filter-gegen-
lichtverschmtzung-...](http://www.astronomik.com/en/filter-gegen-
lichtverschmtzung-filters-against-lightpollution-lpr/astronomik-cls-
filter.html)

[4]: [https://www.cyclopsoptics.com/filters/stc-astro-
multispectra...](https://www.cyclopsoptics.com/filters/stc-astro-multispectra-
clip-filter-canon-full-frame/)

[5]:
[https://secure.flickr.com/photos/joelkuiper/24662326646/in/a...](https://secure.flickr.com/photos/joelkuiper/24662326646/in/album-72157661743016714/)

[6]: [https://www.spaceweatherlive.com/](https://www.spaceweatherlive.com/)

~~~
dheera
If you are in truly favorable conditions it is actually very easy to see the
northern lights with the human eye. It is very in-your-face, ghostly, and hard
to miss. Northern Norway and Swedenstar trails at
higher exposure times. Then there's the need to avoid light pollution. This
map [1] isn't super recent, but it's good enough for most use. And lastly,
just having enough solar activity [2] to see them, especially at lower
latitudes.

[0]: [https://petapixel.com/2015/01/06/avoid-star-trails-
following...](https://petapixel.com/2015/01/06/avoid-star-trails-
following-500-rule/)

[1]:
[https://djlorenz.github.io/astronomy/lp2006/](https://djlorenz.github.io/astronomy/lp2006/)

[2]: [http://www.aurora-service.org/aurora-forecast/](http://www.aurora-
service.org/aurora-forecast/)

------
Dylanfm
I'm lucky to have a good view northwards off the northern coast of Scotland
with very little light pollution. Occasionally an AuroraWatch UK alert will
come through when conditions are right - little or no moonlight and clear
skies. I have some nice lenses (EF 35mm f1.4, Tokina 11-16mm f2.8) and a
trusty Canon 7D. I think I still have quite some time before feeling confident
taking photos of the aurora. In real life it's moving quite subtly. The camera
settings used to capture the aurora (and minimise noise from high ISO) result
in the movement


General Relativity in f(R) theories of gravity*]{}, Phys. Rev. [**D**]{} 75 (2007) 023511 \[arXiv:gr-qc/0612047\].

M. Sharif and Sadia Arif, [*Static Cylindrically Symmetric Interior Solutions in f(R) Gravity*]{}, Mod. Phys. Lett. [**A**]{} 27 (2012) 1250138 \[arXiv:gr-qc/1302.1191\].

S. H. Mazharimousavi, M. Halilsoy and T. Tahamtan, [*Solutions for f (R) gravity coupled with electromagnetic field*]{}, Eur. Phys. J. [**C**]{} 72 (2012) 1851.

R. G. Cai, R. K. Su and P.K.N. Yu, [*Thermodynamics for black strings and p-branes*]{}, Phys.Lett. [**A**]{} 195 (1994) 307-311.

R. G. Cai and Y. Z. Zhang, [*Black plane solutions in four dimensional spacetimes*]{}, Phys. Rev. [**D**]{} 54 (1996) 4891-4898 \[arXiv:gr-qc/9609065\].

E. Dyer and K. Hinterbichler, [*Boundary Terms, Variational Principles and Higher Derivative Modified Gravity*]{}, Phys. Rev. [**D**]{} 79 (2009) 024028 \[arXiv:gr-qc/0809.4033\].

A. Guarnizo, L. Castaneda and J. M. Tejeiro, [*Boundary Term in Metric f(R)     We hereby affirm the Superior Court’s order granting

Progressive’s motion for summary judgment and denying NWI’s motion.

        The entry is:

                           Judgment affirmed.

William J. Gallitto, III, Esq. (orally), Bergen & Parkinson, LLC, Saco, for
appellant National Wrecker, Inc.

James D. Poliquin, Esq. (orally), Norman, Hanson & DeTroy, LLC, Portland, for
appellee Progressive Casualty Insurance Company

York County Superior Court docket number CV-2017-183
FOR CLERK REFERENCE ONLY

    5We find no merit to NWI’s argument that the Duty to Protect provision of the insurance
contract provides an independent basis for coverage and we therefore do not discuss


was presented to five females on a 92 × 16 mm petri dish for 24 h. After 24 h, the male was removed and females placed in a 92 × 16 mm petri dish filled with 25 g (∼100 beans) each. Females were allowed to lay eggs for 24 h before they were removed. The high number of beans resulted in females laying approximately 1--2 eggs per bean, thus within bean larva competition is minimized. Beans with eggs were split into two groups: beans with attached eggs of each female were divided into two virgin chambers (one chamber per group, 25 beans in each chamber). The first group was used to collect data for developmental time and weight at emergence. Adults emerging were collected at three sampling eventssignificantly larger than the dam variance component for weight at emergence for males and for longevity for females ([Table 3](#tbl3){ref-type="table"}). There was no significant concordance of male weight at emergence at the three times of emergence (χ^2^ = 3.43, *N* = 46 families, *P* = 0.18, Friedman test, [Fig. 1 A--C](#fig01){ref-type="fig"}), but in females it was significant (χ^2^ = 8.32, *N* = 44 families, *P* = 0.016, Friedman test, [Fig. 1 D--F](#fig01){ref-type="fig"}).

######

REML estimates of variance components; presented in percent of total phenotypic variance and as raw values for weight at emergence, developmental time, and longevity. Significance of variance components was tested using likelihood ratio tests (LRT)


egg production, lifetime offspring production, and egg-to-adult survival). These results highlight the importance of paternal effects in general and show a step in the direction of an explicit separation of maternal and paternal effect and the possibility to draw conclusions about separate effects of maternal/paternal genotype and common environment. Overall, our finding emphasizes that the role of indirect effects (genetic or environmental) might be seriously underestimated and needs far more attention in future studies (e.g., [@b46]; [@b3]; [@b40]).

Main conclusion
---------------

We found real sex differences in additive genetic variance for life-history and morphological traits that are only moderate (weight at emergence) to slightly (longevity) sexually dimorphic. This highlights that sexes should not be treated the same when it comes to estimates of quantitative genetic parameters. Many quantitative genetic studies havein their name and they want to have nothing to do with the Jewish State’s efforts to survive.

How many of these individuals wrote open letters about the atrocities being perpetrated by Islamic terrorists in Nigeria, Syria, Iraq, Afghanistan and other places?

How many of them marched down the streets of Melbourne or Sydney and other Australian cities to demonstrate their abhorrence at the atrocities taking place on a daily basis in the above named countries? Christians are being buried alive in Iraq, Hamas murdered children and adults who built the terror tunnels in fear that these slaves would reveal their location, Iran is murdering Bahai’s and these are just a few examples of Islamic terror sweeping the world. Where and when did these signatories demonstrate, write open letters and


ask others to break their silence? Only, it seems, when Israel, a democratic country tries to defend itself against these self same barbaric forces, do these Australians of Jewish identity leap into life.

Would those who claim that Israel does not speak in their name have, if they had been British citizens, written in a similar vein while the German rockets were falling on British cities and indiscriminately targeting the civilian population, and claim that Britain’s response was criminal?

When the Allies pounded German cities in retaliation would they have penned open letters against this effort to defeat State terror?

These signatories claim that Israel’s actions are fueling anti Jewish outbursts and thus the victims of Islamic terror are somehow responsible for the tsunami of Judeophobia sweeping many countries. Do these$68,000 funding target.

A genomics approach to kakapo conservation would be a help in developing breeding strategies in the bird's recovery programme, Associate Professor Bruce Robertson of Otago University said.

"We will be able to explore the genetic basis of infertility in kakapo. Only 60 per cent of eggs hatch, compared to about 90 per cent in other birds. Sperm abnormalities contribute to infertility."

Joyce said: "This project presents a world-leading approach to explore how greater genomics understanding across a whole population of an iconic species can contribute to its protection and the potential of this research is huge."

Alongside crowd-funding, the project has been made possible by funding from The Genetic Rescue Foundation, a not-for-profit organisation founded by Kiwi tech entrepreneur David Iorns.


too out-of-date (using bad inheritance) or too up-to-date (too much standard library), and almost certainly inadequate for working with C++ on the level that you'd be expected to at a game company. You can only get to that level by working with the language on your own time with your own projects, which is time you'd have to spend on top of a C++ class anyway. Save your classroom time for concepts that aren't as easily (or in this case, optimally) self-taught.
Take instead a class that requires that you use C (not C++) to implement low level OS features like a shell, a memory allocator, or a scheduler. "Operating Systems" is the typical name for the upper level version of this course (intro courses may be called SystemsHIV-1 (see below).

3.. Substrate Binding
=====================

The nucleic acid binding cleft encompasses the distance between the active sites (∼60 Å) and can accommodate 17 base pairs of DNA/DNA, and 18 base pairs of RNA/DNA \[[@b21-viruses-02-00900]\]. When RT is bound to a DNA/DNA substrate, the nucleic acid adopts A-form geometry near the polymerase active site, and B-form geometry near the RNase H active site \[[@b6-viruses-02-00900]\]. However, in the context of an RNA/DNA substrate the nucleic acid adopts an H-form geometry that is neither A- nor B-form \[[@b7-viruses-02-00900]\]. Multiple contacts are made between enzyme residues and the 2′-OH groups in RNA/DNA substrates that are not available on DNA/DNA substrates \[[@b5-viruses-02-00900]--[@b7-viruses-02-00900]\]. This likely contributes to tighter enzyme binding to RNA/DNA than DNA/DNA \[[@b22-viruses-02-00900]\]. In order for the RNA template to be cleaved in


positive positions proceed 5′ and 3′ from the scissile phosphate, respectively) \[[@b46-viruses-02-00900]\]. Whether this preference is specifically for the RNA base or DNA base is unknown, as is the mechanism by which this preference occurs.

RT makes the decision of whether to bind as a polymerase or an RNase H based on the structure and composition of the nucleic acid substrate itself \[[@b31-viruses-02-00900],[@b47-viruses-02-00900]\], and on the presence and absence of ligands. As previously stated, a recessed DNA 3′ primer end will be bound by the polymerase whether or not the template is DNA or RNA, whereas an RNA fragment recessed on a DNA template will be degraded with the polymerase domain associating with the substrate near the 5′ RNA end. Chimeric primers *i.e.*, RNA-DNA/DNA hybrids are recognized differently byprimer grip, only substrates with a certain minor groove width appear to have appropriate access to the RNase H active site \[[@b7-viruses-02-00900]\].

A co-crystal of RT together with an RNA/DNA PPT substrate shows that the trajectory of the substrate is "missing" the catalytic residues of the active site by about 3 Å, the same as the apparent narrowing of the minor groove \[[@b7-viruses-02-00900]\]. The PPT has other unusual structural features such as an "unzipping" of the primer/template just downstream of the RNase H active site. An unpaired base on the template is followed by a frameshifted A:T pair and a mismatched G:T pair, followed by another unpaired base on the primer strand to restore the register \[[@b7-viruses-02-00900]\]. The next base pair is adjacent to the scissile phosphate, and together


due to the flexibility of integrase in its ability to use substrates of various lengths for 3′-end processing, it remains unclear if the disruption of cleavage specificity by RNase H by small molecules or other techniques is practically useful as a therapeutic option.

6.. Role of RNase H activity in drug resistance
===============================================

All established drugs that target HIV-1 RT have binding sites either at the polymerase active site, or the non-nucleoside binding pocket, a hydrophobic depression created by the binding of non-nucleoside reverse transcriptase inhibitors (NNRTIs) and located near the base of the p66 thumb subdomain, about 10 Å from the polymerase active site \[[@b4-viruses-02-00900],[@b64-viruses-02-00900],[@b65-viruses-02-00900]\]. It is therefore not surprising that most of the major known resistance-conferring mutations are also located in the vicinity of the polymerase active site. However,mechanism \[[@b79-viruses-02-00900]\]. As N348I and A360V often appear along with other thymidine analog mutations (TAMs) in the clinic, they both show resistance to AZT. RT enzymes containing N348I and A360V reduce RNase H activity by selectively dissociating from RNase H-competent (polymerase-independent) complexes \[[@b79-viruses-02-00900]\]. N348I had no effect on substrate binding of the polymerase domain, and A360V rescued a modest binding defect introduced by TAMs, which agrees with the observation that A360V appears later in therapy after the emergence of TAMs and N348I \[[@b79-viruses-02-00900]\]. The A360V and N348I mutations also appear to increase processive DNA synthesis, which points to an additional RNase H-independent contribution to resistance \[[@b79-viruses-02-00900]\].

The RNase H mutant Q509L likely operates in a similar mechanism, although it appears only rarely in therapy-experienced patient \[[@b67-viruses-02-00900],[@b80-viruses-02-00900],[@b81-viruses-02-00900]\]. Also, G333D/E mutation


RT \[[@b94-viruses-02-00900]\]. The diketo acid 4-\[5-(benzoylamino)thien-2-yl\]-2,4-dioxobutanoic acid (BTDBA), was shown to bind to the isolated HIV RNase H domain in a metal-dependent fashion by isothermal titration calorimetry \[[@b94-viruses-02-00900]\]. It also did not appear to require the presence of the nucleic acid substrate for efficient binding \[[@b94-viruses-02-00900]\]. The presence of the 3-oxygen pharmacophore suggests a similar mode of inhibition to the N-hydroxyimides. However, despite effectively inhibiting RNase H activity *in vitro*, this compound did not show inhibition of viral replication in cell culture \[[@b94-viruses-02-00900]\]. Another diketo acid-based inhibitor, RDS1643, also specifically inhibited HIV RNase H activity while not affecting the HIV polymerase activity, or the RNase H activity of related enzymes such as *E. coli* and avian myeloblastosis virus (AMV) ([Figure 7C](#f7-viruses-02-00900){ref-type="fig"}) \[[@b86-viruses-02-00900]\]. Unlike other active site inhibitors, RDS1643sequence from the tRNA that is still associated with the (−)-strand DNA. Here, the tRNA is removed by the RNase H activity, leaving a single ribonucleotide (rA) at the 3′ end of the U5 sequence (shown in red). **G** In the second, or (+)-strand transfer, the PBS sequences on both strands associate. This step occurs predominantly in an intrastrand fashion. **H** Both DNA strands are extended to the ends of their templates, forming the provirus that is ready to be integrated into the host genome by integrase. The long terminal repeats (LTRs) that are formed as a result of reverse transcription are shown.](viruses-02-00900f1){#f1-viruses-02-00900}

![**A** Crystal structure of HIV-1 RT (PDB code: 1RTD. The p51 subunit is shown in orange, while the p66 subunit is divided into the fingers (cyan),


favor. Id. Summary judgment is not appropriate unless the evidence demonstrates that "there is no genuine issue of material fact and that the moving party is entitled to judgment as a matter of law." Fed. R. Civ.P. 56(c).

9
A defendant's entitlement to qualified immunity is a question of law, also to be reviewed de novo. Cagle, 334 F.3d at 985.

III. DISCUSSION3

10
As we have often stated, "[q]ualified immunity offers complete protection for government officials sued in their individual capacities as long as their conduct violates no clearly established statutory or constitutional rights of which a reasonable person would have known." Lee v. Ferraro, 284 F.3d 1188, 1193-94 (11th Cir.2002) (internal citations and quotation marks omitted). This immunity "allow[s] government officials to carry out their discretionary duties without the fear ofprior cases and the case under consideration"). See also Gutierrez v. City of San Antonio, 139 F.3d 441, 446 (5th Cir.1998) (applying Garner "deadly force" rule to determine whether officers were qualifiedly immune for hog-tying suspect).

35
By 2001, it was well-established in this circuit that "deadly force" means force that creates a substantial risk of causing death or serious bodily injury. Pruitt, 771 F.2d at 1479 n. 10. The CCSD policy in 2001 employed a near-identical definition. Moreover, by 1986, we had recognized the potentially lethal nature of an automobile. See Gualdado, 794 F.2d at 1535, and other cases cited on pages 1314-15, supra.

36
We are satisfied that common sense would inform any reasonable officer that there would be substantial risks of death or bodily harm if he used his


asGarner specifically based its holding on the assumption that a fleeing suspect would escape. 471 U.S. at 11, 105 S.Ct. 1694. We note, however, as did the district court, that there were other means to track Harris down as the pursuing officers had a description of the vehicle as well as the license plate number. We also note that absolutely no warning was given that Scott intended to use deadly force.

11
 Nor does the evidence show thatScott or the other officers were in immediate danger or threatened with imminent harm. Accepting Harris' version of events, Harris did not attempt to ram, run over, side-swipe, or swerve into any of the officers (which might have put their lives in danger in the parking lot), nor did he attempt anysuch conduct once he was back on the highway immediately before the seizure. Cf. Hernandez, 340 F.3d at 623 (evidence of plaintiff's attempts to intentionally drive his car directly into officer's vehicle supported finding that officer's use of deadly force was reasonable); Smith v. Freland, 954 F.2d 343, 347 (6th Cir.1992) (use of deadly force not unreasonable where suspect "posed a major threat" to officers manning roadblock by driving directly into them on a residential dead-end street and "had proven he would do almost anything to avoid capture").

12
 These facts are not comparable to those inHarris. In the light most favorable to Harris, there is no comparable evidence that Scott had arguable probable cause to believe that Harris posed an immediate risk of death or serious danger to


SUISUN CITY — Kittens in a Blender isn’t as bad as it sounds – it’s a card game that involves saving little kitties before they end up . . . well, in the blender.

That’s just one of the many off-the-grid board games that Fairfield’s Bad Zero Games, a family “pop up” game store, has had at its game days at the Hampton Inn and Suites in Suisun City since its inception six months ago.

A group of game enthusiasts gathered Sunday in one of the hotel’s conference rooms to play games such as Abyss, Hanabi, Pandemic or The Castles of Burgundy.

For Ryan Faircloth, a technical sergeant in the Air Force, stationed at Travis Air Force Base, the game days are a way to get back to the “roots ofI figure if I don't sleep a lot tonight, then I will on the bus. And then Saturday I have about 16 and a half hours of traveling to do, so if I'm tired for all that, great, I'd love to sleep on the 11 1/2 hour flight I have from Madrid to Texas!

Update (added 26/12/2013): that was, of course, a horrible plan. The first half of the bus ride I barely slept due to discomfort and the large man snoring just in front of me. Also, because I was flying all day long, I wasn't mentally tired, and therefore slept for a total of maybe 20 minutes during the 15 hours I spent in planes. I did however arrive in SF at 22h, and by the time


a personal item carry-on and a carry-on bag. I'm only going to take a rolling backpack with me on the way, and then likely come back with more carry-on weight than I went with. I plan to bring back a lot of health food items that are expensive or unavailable here, and I'll want to have space for it all. :)

In order to get all this packed, I am using my preferred method..

#1 Roll the thinner items (tank tops, tops, skirts, etc) and then put then in the cracks of the suitcase on the bottom

#2 Pack stuff on top of it, and put all socks, underwear, tights and leggings together in those plastic zip bags that tend to come with a suitcase.

#3 Shove anything that might be remaininglove this schedule anyways, but have been having a hard time living it since Spain's hours tend to be pushed back. We'll see what happens!

What tricks and tips do you lovely people have for aiding jet lag? Would love to hear from some of you!

This post was going to be about jet lag, and be full of funny, witty little things, but really, it's 5am to me right now, and that's just not going to happen. I keep mistyping most of my words and am pressing the backspace/delete keys more than I am letter keys. So yes, now I'm going to put myself to bed. I love the idea of going to bed at 20:00. It makes me feel more productive tomorrow already!

Man am I happy to be


of chilled out indie/electro/hip hop.. just listen to it and relax with some tea or something. Current status: paused

El video de la familia Real que no quieren que veamos en Espana (the video of the Real family they don't want us to see in Spain) -- still haven't started it, probably because for me it's almost like homework to have to watch/listen to it in Spanish, but I'll get to it. Maybe in the airport or on the plane while I am FLYING HOME TO CALI THIS SATURDAY!! WHOOP! Current status: waiting

Icelanders Overthrow Government and Rewrite Constitution After Banking Fraud-No Word from US Media -- I mean, come on people, do you still think it's not possible for us to overtake the government and fix the situation into suggest me some good Italian artists. I am going to begin learning Italian, and figure music is a perfect way to start :)

YouTube -- per the recommendation of my new friend, I am listening to a full album on YouTube by Jovanotti. It's really great! Take a listen! Current status: listening

Aguapedia.org -- I'm considering beginning a masters while I am here that is all about different processes and ways to clean and sanitize water to make it drinkable and distributed to countries that lack clean water. As I said, this is my passion, and as such, it could be a good thing to study.

Spirit Hoods -- I bought the grey wolf one on the Black Friday sale day, but I don't think it is really my spirit