partial or total abstinence from alcohol could be due to an underlying poor health.

Additionally, although compared to non-smokers, former and current smokers had lower health scores as expected \[[@CR12]\], the latter groups did not differ from each other in terms of the health metric. This could be possibly explained by the fact that current, ex- and passive smoking is associated with other risk factors, arising a potential confounding design \[[@CR13]\]. Moreover, the reason for smoking cessation is often a non-reversible poor state of health.

Maintaining a relatively high level of health, functioning and well-being throughout life-course, could be seen as a precursor of longevity and lowered risk of chronic diseases \[[@CR14]--[@CR16]\]. In recent years, healthy aging has been addressed through a multidimensional approach, in order to capture and attributeaccuracy or integrity of any part of the work are appropriately investigated and resolved. NK particularly applied the statistical analyses and wrote the manuscript. FFC, ASN, ST and JLAM developed the methodology. JMH, SC and DBP supervised the aforementioned tasks and critically reviewed the manuscript.

Ethics approval and consent to participate {#FPar3}
==========================================

All participants have given written informed consent. Ethical approval for all the ELSA waves was granted from the National Research Ethics Service (MREC/01/2/91). The ELSA study is one of the longitudinal studies included in the ATHLOS project. All the studies included in the ATHLOS project have given permission for the secondary use of their data by the ATHLOS consortium.

Consent for publication {#FPar4}
=======================

Not applicable.

Competing interests {#FPar5}
===================

The authors declare that they have no competing interests.

Publisher's Note {#FPar6}
================

Springer Nature remains neutral


UTRGV receives $38,000,000 gift from Legacy Foundation

The University of Texas Rio Grande Valley was given what the school calls a transformative and remarkable gift.

During a news conference at the UTRGV School of Medicine in Harlingen, the Legacy Foundation announced it awarded the universtiy $38,000,000 for health care education.

UTRGV President Guy Bailey said what the money will do for the university is remarkable.

“This gift will change everything about what we do. The benefits of this gift you will see for a long time, as you see the university grow and develop,” Bailey said

University of Texas System Regent and Harlingen physician Dr. Nolan Perez, said it is gifts like these that will help catapult the university to another level.

“As a physician here I’m really excited that we can finally put         sb.append("Code: ").append(getCode()).append(",");
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in the MWACS footprint. []{data-label="t.rates"}

3LAC \[s.3lac\]
---------------

The third LAT AGN catalogue (3LAC) includes a total of 1563 gamma-ray sources among the 2192 $|b|>10^\circ$ 3FGL sources. These 3LAC sources are identified or statistically associated with AGNs by means of a Bayesian association [@Abdo2010] or a likelihood ratio [@Ackermann2011b] method. These 1563 gamma-ray sources are associated with 1591 objects (28 sources have double associations), consisting mostly (98%) of blazars or blazar candidates.

From the entire sample, @Ackermann2015 have defined a “clean” subset of 3LAC single-association sources free of any analysis problems (e.g. sources strongly affected by changes in the diffuse emission model). In the following, whenever we mention the 3LAC we implicitly refer to this clean subset, which includes 1444 objects with 414 FSRQs, 604 BL Lacs, 49 BCUs, 353 blazar candidates, andwhich it is $\langle \alpha_\mathrm{low} \rangle =0.866\pm0.002$. FSRQs are marginally steeper ($\langle \alpha_\mathrm{low} \rangle=0.56\pm0.02$) than BL Lacs ($\langle \alpha_\mathrm{low} \rangle=0.49\pm0.05$).

For each source, we also calculated the non-simultaneous spectral index $\alpha_\mathrm{0.18-1}$ between 180 MHz and $\sim1$ GHz. The results show a flattening of the spectra from low to higher frequency for FSRQs of about $\langle \Delta\alpha \rangle=\langle \alpha_{0.18-1}\rangle-\langle\alpha_\mathrm{low}\rangle \sim-0.25$, while BL Lacs maintain the same spectral index. This difference between FSRQs and BL Lacs stems from the average low flux density of BL Lacs at $\sim1$ GHz because faint sources can reach the MWACS detection threshold more easily if they steepen at low frequency.

Finally, for the subset of sources with AT20G counterparts, we also computed the high-frequency spectral index $\langle \alpha_\mathrm{1-20}\rangle$ between $\sim1$ and 20 GHz. In this frequency


statistically significant result.

The histogram in the left panel of Fig. \[f.radiogamma\] shows that the gamma-ray flux distribution of the gamma-ray blazars without a MWACS counterpart is consistent with the trend estimated for the detected sources. Future, deeper low-frequency surveys will probe this population and provide deeper insight into the possible correlation.

Other gamma-ray sources in the MWACS
------------------------------------

We list in Table \[t.sample3\] the ten UGS that have one or more counterparts in the MWACS catalogue. Given the high spatial density of MWACS sources, it is not possible to claim any of them as a statistically significant association. We nonetheless list them here as a reference for possible follow-ups. In particular, 3FGLJ0026.2$-$4812 and 3FGLJ2130.4$-$4237 are spatially consistent with two moderately bright and flat-spectrum MWACS and SUMSS sources: MWACSJ0025.6$-$4816, with $S_{0.18}=0.65$ Jy andthis is bound to increase at lower flux density limits. It will be necessary to take additional features into account to recognize sources of known gamma-ray emitters. This includes for example a flat spectrum (for core-dominated blazars) or pulsed emission.

MG acknowledges financial support and kind hospitality during his visits at Curtin University and Sydney Institute for Astrophysics. We acknowledge financial contribution from grant PRIN$-$INAF$-$2011. This research has made use of the VizieR catalogue access tool, CDS, Strasbourg, France, and of NASA’s Astrophysics Data System.\
This scientific work makes use of the Murchison Radio-astronomy Observatory, operated by CSIRO. We acknowledge the Wajarri Yamatji people as the traditional owners of the Observatory site. Support for the operation of the MWA is provided by the Australian Government Department of Industry and Science


all hope, yet. WOA provides Microsoft an outlet to keep pressure on Intel/AMD to keep pushing the boundaries on chip design and performance. With ARM up its sleeve, Microsoft now has a viable alternative to its traditional Windows line of products and this makes them a bigger threat, even if it has yet to materialize.

The question is not if Windows RT is worth Microsoft’s investment, but when will it pay off. While it may be easy to say now that they should dump the platform, at this time, that would be a foolish move.

Even though it is off to a rough start, Windows RT, which could in all honesty use a re-branding, something like Windows Touch, keeps the doors open for the Windows platform. It's not that Windowsunconditional, open-ended humanitarian truce between Israel and Hamas, followed by a negotiated long-term ceasefire based on the Egyptian initiative.

Rocket falls in Ashkelon; no casualties

Official says truce with Hamas ‘open-ended’

A senior military official tells Army Radio that the security establishment is viewing the current humanitarian truce with Hamas as an “open-ended respite” from the fighting.

Despite the relative quiet since Sunday, the IDF continues to destroy attack tunnels in the Strip, and the military official says that if Hamas breaks the humanitarian truce, the army will respond forcefully.

‘Last time we listened to the US, Hamas took Gaza’

“The international pressure has begun,” Elkin tells Ynet. “When we once listened to the Americans and allowed Hamas to participate in elections, Hamas took over Gaza and we received a terrorist entity. Hamas is


alliance with organizations and entities that would be happy to see Israel disappear from the map.”

Says Issacharoff: “I prefer to bet on the first option… that Kerry just doesn’t understand who’s playing against whom in the Wild Mideast.

Over 100 anti-Semitic acts in UK in past month

More than 100 hate crimes have been committed against Jews this month in the UK, reports the Daily Mail. The number is more than twice the normal figure.

The rise comes during fighting in the Gaza Strip between Israel and Hamas, who are joined by other terrorist groups.

Over the past month, four Muslim teenagers attacked a rabbi outside a Jewish school in Gateshead. In Belfast, bricks were thrown through the windows of the city’s only synagogue on two consecutive nights.

A London pro-Israel organization receivedIsraeli-US ties — US officials

Obama administration officials are fuming over Israeli criticism of Secretary of State John Kerry’s latest bid to secure a ceasefire between Israel and Hamas.

In unusually harsh language, officials say the criticism of Kerry could put the relationship between the US and Israel in jeopardy. They also say the personal attacks on Kerry cross a line and are particularly disappointing at a time of active conflict.

Hamas condemns ‘slaughter of children’ at Al-Shati

Israel Radio’s Gal Berger quotes Hamas spokesman Sami Abu Zuhri on Twitter condemning the attacks on Shifa hospital and the Al-Shati refugee camp, which the IDF says were the result of an Islamic Jihad rocket misfire.

“The slaughter of children in the Al-Shati refugee camp is a war crime and a result of silence of


news.

Television images show swastikas and the name “Hamas” spray-painted on the synagogue’s columns.

The incident follows another on Saturday in which a Miami Beach family found their cars covered in eggs and the words “Hamas” and “Jew” written on the windows.

“I mean, honestly, it makes you question if it’s safe to walk around wearing your yarmulke, like how safe you really are in America,” says Josh Rosenberg, one of the family’s neighbors.

Infiltrators opened fire on troops, IDF says

Kerry calls for Gaza disarmament

US Secretary of State John Kerry says international efforts to agree to a truce between Israel and the Palestinians in Gaza must lead to the disarmament of Hamas.

Kerry, who arrived back in Washington late Sunday after a week-long mission in the Middle East to try to stop theto resolve the crisis in Gaza… must lead to the disarmament of Hamas.” In a ceasefire proposal Kerry had submitted to Israel on Friday, no disarmament of Hamas was mentioned.

Israeli ministers had unanimously rejected the draft, arguing that it undermined the Egyptian ceasefire proposal that Israel had previously accepted and Hamas had rejected, and reflected the input of Turkey and Qatar to the clear benefit of Hamas, sources told TOI earlier Monday.

The wording marked an upgrading of Hamas’s standing, to an entity on an equivalent level with Israel, the sources said. And it provided specific gains for Hamas, while including only amorphous language regarding Israel’s security needs, they said.

However, Kerry’s proposal did reflect “a position that both demilitarization and the reconstruction of Gaza are important agenda items that


military response is excessive, and 31% believe it’s about right.

Hamas says it tried to kidnap soldier

Palestinian death toll said to hit 1,067

Palestinian emergency services spokesman Ashraf al-Kidra says five Palestinians were killed in an Israeli strike on Khan Yunis in southern Gaza late on Monday.

The strike hit close to the city’s Islamic University, killing four members of one family, and leaving another 20 people injured, he announces.

Their deaths raised the overall Palestinian death toll in Gaza to 1,067, he says.

Israel says hundreds of the dead are Hamas gunmen.

On Sunday, Palestinian officials said that the death toll stood at 1,031, retracting an earlier announcement that placed it at 1,060, Ynet reports. Officials had mistakenly counted 147 bodies retrieved from rubble in the Gaza Strip, and later said there wereSo what: Similar to Nest Labs' flagship solutions, Control4 makes a variety of home automation products to electronically integrate everything from lighting and home theater to climate control and security. As a result -- and given Google's propensity for purchasing multiple companies in the same industry -- Google's big bet on smart homes has unsurprisingly spurred speculation Control4 could be its next acquisition target.

Now what: While that'd be great for Control4 investors considering the hefty sum Google paid for Nest, I'd prefer not to bet on an acquisition as a sure thing. With shares of Control4 currently trading above 59 times next year's estimated earnings, I think Control4 investors would be wise to take at least some of their chips off the table.

Author

As a technology and consumer goods


– in other words, how to train a new employee to be an all star.

If you would like to add our infographic to your website you can use the code provided below:

The module will bring the administratively-complex process of auto-enrolment to life, making it incredibly clear what HR and payroll professionals need to do and when. In turn this will allow each department to retain control over their own tasks at the same time as encouraging legislative compliance.more...

ABOUT CASCADE HR

Cascade HR is a well-established, award-winning provider of fully-integrated HR and payroll software. The company is renowned as much for its quality of project management and ongoing customer service levels, as it is its dynamic technology. Over 750 satisfied clients are now utilising Cascade’s software throughout varied private andPoetry magazine, where he was editor for 10 years. The most straightforward version of those years would be a literary tell-all, along the lines of the former New Yorker editor Robert Gottlieb’s “Avid Reader.” But “He Held Radical Light” is something else: a collection of private memories, literary criticism and theology, plus an eccentric anthology of poems Wiman holds dear, all drawn into an argument about art and faith.

An acquaintance flattered me and compared a photo of mine to Eugène Atget’s work, so I had to learn more. In school, and in my life, I’ve studied the painting masters, visited art museums all over North America and Europe, but I haven’t filled in the photography part of my art education as thoroughly, yet. A friend suggested I consider


not, it’s your own choice, and your choice alone to make.

For some reason, when I saw the above sculpture installation at LACMA, I didn’t remember that Walter De Maria was part of the NYC underground scene that also evolved into The Velvet Underground…

Walter De Maria, a reclusive American sculptor whose multifaceted achievement and sly Dadaist humor helped give rise to earthworks, Conceptual Art and Minimal art, on an often monumental scale, died on Thursday in Los Angeles. He was 77 and lived in New York.

…

In a career of more than 50 years Mr. De Maria made drawings of all-but-invisible landscapes, gamelike interactive wood sculptures and a record of himself accompanying the sound of crickets on the drums.

Mr. De Maria himself was a sometime percussionist who played in jazzthe N-rich microbial remains pool which makes them inactive and ready to be degraded by other enzymes.

Functional traits
-----------------

A functional microbial group is composed of microbes with certain functional traits. Functional traits can be classified in 'life-history' traits (microbial cell sizes and associated turnover rates, cell C : N stoichiometry and the microbe\'s investment in enzyme production) and 'substrate-specificity' traits (the ability to produce specific enzymes to degrade specific substrates).

1.  Cell size and turnover rates: Each functional group is characterised by its 'maximum cell size'; (MCS), which is the cell size at which a microbe divides and colonises neighbouring cells. All individuals of a functional group will thus have cell sizes distributed between half of MCS and MCS. We coupled cell size and growth rates in the model


Ninety per cent of enzymes produced by 'plant degraders' specifically degrade plant material, whereas 10% degrade N-rich microbial remains. 'Microbial-remains degraders' produce enzymes degrading C-rich and N-rich microbial remains (each 50% of total enzyme production). 'Opportunists' were fast-growing microbes without any enzyme production capabilities, assuming this a realistic component of the microbial decomposer community. We ran the model at four different initial litter C : N ratios (from 45 to 75) and recorded the C : N ratio of total dissolved organic material (aggregated over the grid) as a measure of microbial C : N limitation at any time point. We calculated community carbon use efficiency (CCUE, i.e. the fraction of the total carbon uptake that is used for microbial growth) as an emergent result from the outputN ratios of DOM were still positively correlated with litter C : N ratios (Fig. [6](#fig06){ref-type="fig"}), varying between 22 (for litter with C : N 45) and 28 (for litter with C : N 75). In both models, DOM C : N ratios were at least 50% lower than litter C : N ratios. The surprising decoupling of DOM and litter C : N ratios in our community model is also supported by empirical data from a litter decomposition study where beech leaf litter from four different sampling sites in Austria (varying in initial C : N ratios) had been incubated under laboratory conditions for up to 65 weeks (Wanek *et al*. [@b44]; Leitner *et al*. [@b19]; Mooshammer *et al*. [@b26]). Results from that study show that (1)


study and Sarah E. Evans for helpful comments on an earlier version of this manuscript. CK is grateful to the team of the Winter school on Ecological Modeling 2009 (Helmholtz Centre for Environmental Research, UFZ, Leipzig, Germany). CK was funded by a post-doctoral fellowship from the International Institute for Applied Systems Analysis (IIASA) and by the National Research Network MICDIF (S-10001-B17, Austrian Science Fund, FWF). Open access publication of this study was enabled by the Austrian Science Fund (FWF), through a grant to UD (TECT I-106 G11) for the research project 'The Adaptive Evolution of Mutualistic Interactions' as part of the multinational collaborative research project 'Mutualisms, Contracts, Space, and Dispersal' (BIOCONTRACT) selected by the European Science Foundation (ESF) as part of the European Collaborative Research (EUROCORES) Programme 'Thework OK.

A:

After a bit of research and trail and error, I found a work around, that will not replace the navbar when you enter the movie playback mode. Hopeefully this does not cause problems with app approval, but based on this post, I think it should be fine:
http://developer.apple.com/iphone/library/qa/qa2009/qa1637.html
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        CGContextDrawImage(ctx, CGRectMake(0, 0, self.frame.size.width, self.frame.size.height), image.CGImage);
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as Apex SQL Clean.
You might find that you can do all you need for now within the free trial period.

A:

I just created a program to grab all the stored procedure names from the database.  I then read through all the files in my project manually, and check to see if they contained the stored procedure name.  If the name was not found in any files, I added it to a list.
I was hoping to find an easier way to do this, but this works for what I needed.

Manganese toxicity: muscarinic receptor binding in the mouse brain.
In the present study we determined the effect of repeated administration of manganese chloride on the binding parameters of [3H]quinuclidinyl benzilate (3H-QNB) in striatum, frontal cortex, and hippocampus of mice. Daily intraperitoneal injections of manganese chloride (5 mg Mn/kg) 5 d/wk during 9 wk did not alter the receptor density (Bmax) and the dissociation constant (Kd) of 3H-QNB in the different brain regions studied. These results suggest that chronic treatment with manganese does not affect the binding characteristics of 3H-QNB to the cholinergic muscarinic receptors in mouse brain.


Bushfire research

Our bushfire research is improving the understanding of fire, and improving technologies and strategies to save lives and limit damage.

Bushfire has been part of the Australian landscape for millions of years. Much of our vegetation has evolved with fire, and like the vegetation in other harsh and dry environments, it has developed characteristics that promote the spread of fire.

Australian scientists are developing reliable tools for predicting bushfire behaviour to save lives and limit damage.

[Image of a green map of Australia with a flame in the middle of it appears on screen]

Narrator: Bushfires are part of life in Australia,

[Animation shows clusters of flames moving through grasslands and consuming a house]

and when they burn out of control near populated areas can cause significant loss of life and property.

CSIRO hastheir fourth road win against an AP Top 25 opponent and third under seventh-year coach Leon Rice. Boise State beat unranked Oregon 74-72 last year in Boise.

Oregon: The Ducks won't leave the state for their next eight games to finish 2016, capped by visits from No. 9 UCLA and USC in late December to start Pac-12 play.

Up next

Boise State hosts SMU on Wednesday night before traveling to play Evansville as part of the Mountain West/Missouri Valley Challenge on Saturday.

Oregon hosts Western Oregon, which reached the NCAA Division II Final Four last year, on Wednesday night and then hosts Savannah State on Saturday to continue a five-game homestand.


a very conscious decision to completely abandon the Republican Party’s anti-slavery roots. (Abraham Lincoln won the Presidency in 1860 in a three way race as the candidate of the newly-formed, somewhat-anti-slavery Republican Party.) In the words of Manning Marable, “(Dwight D.) Eisenhower had received the support of 39 percent of the African-American electorate in his 1956 successful reelection campaign, and at the time the Republican Party had a strong liberal wing that was pressuring the White House to take bolder steps on racial policy.” (p. 118) Twelve years later, that historical legacy was deliberately jettisoned and, instead, “law and order,” getting “welfare bums” off welfare and opposition to busing became the major issues for Nixon, Vice-Presidential candidate Spiro Agnew and their ilk. “‘You can forget about the Vietnamthe lack of ‘personal responsibility’ of those on public assistance.” (Marable, p. 82)

Gush and Bore

2000 brought us Bush and Gore, or as some called it, Gush and Bore. The most memorable thing about their three Presidential debates and their campaigns in general was how similar they were on the issues, how little Democrat Gore tried to draw out major areas of disagreement with Republican Bush. “The greatest tragedy of the 2000 presidential race, from the vantage point of the African-American electorate, was that the black vote would have been substantially larger if the criminal-justice policies put in place by the Clinton-Gore administration had been different. . . more than 4.2 million Americans were prohibited from voting in the 2000 presidential election because they were in prison or had


Rhodanese and ALA-S in mammary tumor and liver from normal and tumor-bearing mice.
1. Basal levels and allyl-isopropylacetamide (AIA) or veronal induced levels of delta-amino-levulinate synthetase (ALA-S), cytoplasmic and mitochondrial rhodanese were determined in tumor (T) and liver of both normal mice (NM) and T-bearing mice (TBM). 2. Rhodanese tumoral mitochondrial levels were higher than the hepatic normal mitochondrial fraction, while the cytoplasmic activity was nearly equal in all sources. 3. In neither case was the activity of tumoral ALA-S and rhodanese altered by any of the porphyrinogenic drugs. 4. Mitochondrial and cytoplasmic rhodanese activity was also measured in tumor and liver of TBM at different intervals after transplantation. We concluded that the behaviour of rhodanese is a property inherent to the tissue and not one attained with time.duration of the 2nd Formation. As of September 3 the division was back in 21st Army, still in the Kremenskaya bridgehead. On the following day it was ordered to attack XI Corps again, in an attempt to prevent 22nd Panzer Division from moving eastward towards Stalingrad. This made little impression, and for the next months the 321st continued to hold its positions and rebuild.

Operation Uranus
In November the division was transferred to 65th Army (the former 4th Tank Army) on the right flank of Don Front. In the planning for Operation Uranus, 21st Army was to have a leading role in breaking out of the Kletskaya bridgehead, but the 65th was to provide support on its left. On November 19 the 321st concentrated its forces on a 4km sector


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              you might well think of this initial $1,000 as a "down payment" on the extras that you otherwise wouldn’t be able to afford. Again, a high-yield savings account is one option, as would be a CD that will mature at the time you expect to use the funds. However, if you have a longer timeline, you could also consider a custodial brokerage account.

With a brokerage account, you could invest in a broad-based stock mutual fund or ETF. That would give you the potential for more growth with the flexibility to access the funds when you need them. And by reinvesting the dividends, your investments can continue to grow. Of course, you always have to keep in mind that the risk with the stock market is that your investment


labeling of the cannabinoid CB2 receptor. Our work shows clearly that an antibody may pass stringent positive controls, but still fail specificity tests using strong negative controls.

Antibodies for G protein-coupled receptors (GPCRs), of which the cannabinoid CB2 receptor is a member, have been particularly challenging ([@bibr3-0022155414530995]; [@bibr5-0022155414530995]; [@bibr9-0022155414530995]). Despite this, only very recently have commonly used CB2 antibodies been critically scrutinized using CB2 knock-out mice and other controls for their use in western blotting ([@bibr11-0022155414530995]). Despite a dearth of critical testing up to now, western blotting continues to be used to determine apparent CB2 expression, with one antibody in particular used in the majority of these studies ([@bibr2-0022155414530995]; [@bibr9-0022155414530995]; [@bibr12-0022155414530995]; [@bibr14-0022155414530995]; [@bibr18-0022155414530995]; [@bibr32-0022155414530995]; [@bibr34-0022155414530995]) despite the validity of this antibody being called into question over a decade agoloading buffer (8% SDS, 40% glycerol, 5% beta mercaptoethanol, and 0.04% bromophenol blue in 240 mM Tris-HCl, pH 6.8) and incubated at 95C for 5 min.

### Immunoblotting {#section7-0022155414530995}

Samples derived from cells or rat tissue, or human alpha-enolase protein (MBS203689, MyBioSource Inc.; San Diego, CA) were electrophoresed on a 7.5% Tris-Bis gel alongside a molecular weight marker (Bio-Rad), and transferred to a polyvinylidene fluoride membrane, which was blocked for 4 hr with 10% skim milk powder and 0.1% BSA in a solution of 0.1% Triton X-100 in Tris-buffered saline (T-TBS). Membranes were then probed with (1) a rabbit-derived polyclonal antibody raised against amino acids 20-33 of the N terminus of the human CB2 receptor (\#101550, Cayman Chemical Company; Ann Arbor, MI), at a concentration of 1:500 in western antibody


diluent (0.1% BSA in T-TBS) or (2) a 1:4000 solution of a mouse-derived polyclonal antibody against beta-actin (\#sc-47778, Santa Cruz Biotechnology Inc.; Dallas, TX). Membranes were incubated overnight at 4C. Following washing in T-TBS, membranes were incubated with horse radish peroxidase-conjugated sheep anti-rabbit IgG (Chemicon; Temecula, CA) at a concentration of 1:1000 or anti-mouse IgG (Santa Cruz Biotechnology Inc.) at a concentration of 1:1000 in T-TBS for 1 hr at room temperature. Bands were visualized on enhanced chemiluminescence (ECL) film with western blot ECL reagents (GE Healthcare; Buckinghamshire UK).

Samples derived from wild type and CB2 knock-out mice were separated on 10% Tris-glycine gels and proteins then transferred to a nitrocellulose membrane (Amersham Biosciences, GE Healthcare; Piscataway, NJ). After transfer, membranes were blocked for 1 hr with a solutionhalf stained with colloidal Coomassie Blue. The stained gel was then overlaid on to the developed film of the immunoblot detection of CB2, performed with the other half of the gel. To correctly align the gel with the corresponding immunoblot signal, the gel size was adjusted to exactly the size of the gel used for blotting by short incubation steps in 50% methanol in water. Regions of the fixed gel corresponding to bands on the film were excised and subjected to in-gel digestion with trypsin using a robotic workstation for automated protein digestion (DigestPro Msi, Intavis AG; Cologne, Germany). The protocol for automated in-gel digestion is based on the method of [@bibr29-0022155414530995]. Eluted peptides were concentrated using a centrifugal vacuum concentrator.

### Liquid Chromatography-coupled Mass Spectrometry (LC-MS) {#section10-0022155414530995}

Samples were


short 7 amino acid sequence stretch (MQEFMIL) from alpha-enolase in all samples corresponding to the immunoblot signal at 44 kDa. Alpha-enolase is a widely expressed glycolytic enzyme and it is highly conserved among mammals. This protein is almost exclusively cytosolic, and has a reported molecular mass of \~47 kDa when separated by SDS-PAGE and detected with immunoblotting ([@bibr33-0022155414530995]). We next attempted to confirm cross-reactivity of the antibody with this protein using western blot analysis. However, any attempts to detect purified human alpha-enolase (MBS203689, MyBioSource Inc., CA, USA) by immunoblotting using the CB2-antibody failed (data not shown) and we therefore excluded alpha-enolase as a potential cross-reactant. Thus, the identity of the cross-reacting protein at this molecular weight remains to be determined.

Sensitivity of Mass Spectrometry {#section18-0022155414530995}
--------------------------------

We tested whether the methodsis expressed in sufficient abundance along with evidence that the antibody also labels other unidentified proteins of a very similar molecular weight to expected CB2 isoforms. Thus, although the antibody appears to have a relatively high affinity and avidity for CB2, it lacks specificity and is therefore unreliable. Reliance on positive controls alone, along with consideration of band number and molecular weight in western blotting, could mislead researchers into thinking that they have strong evidence for the antibody's reliability.

To summarize the key results, the antibody detected a strong band at 37 kDa in membrane-enriched homogenates of rat CB2-overexpressing CHO-K1 cells, in line with the expected weight and distribution of the unmodified short isoform of the rat CB2 receptor. This result was confirmed by LC-MS/MS analysis, which positively identified


at the University of Otago for providing control CHO-K1 cells.

**Declaration of Conflicting Interests:** The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

**Funding:** The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Marsden Fund of New Zealand (Ashton) and an IRG Marie-Curie Fellowship (Marchalant, NGINFAD).

[^1]: These authors contributed equally to this work.
= new Intent(Intent.ACTION_VIEW, gplusURL);
        	            intent.setFlags(Intent.FLAG_ACTIVITY_NEW_TASK | Intent.FLAG_ACTIVITY_CLEAR_TOP);
        	            getContext().startActivity(intent);

			}
			if (twitterName != null) {
	                    Uri twitterURL = Uri.parse("https://twitter.com/" + twitterName);
        	            final Intent intent = new Intent(Intent.ACTION_VIEW, twitterURL);
        	            intent.setFlags(Intent.FLAG_ACTIVITY_NEW_TASK | Intent.FLAG_ACTIVITY_CLEAR_TOP);


return null;
        }
    }

    private String getMd5(String devEmail) throws NoSuchAlgorithmException {
        MessageDigest md = MessageDigest.getInstance("MD5");
        md.update(devEmail.getBytes());
        byte byteData[] = md.digest();
        StringBuffer sb = new StringBuffer();
        for (int i = 0; i < byteData.length; i++)
            sb.append(Integer.toString((byteData[i] & 0xff) + 0x100, 16).substring(1));
        return sb.toString();
    }
}
or invalid access token."
msgstr ""

#: src/errormessages.js:33
msgid "Document cannot be saved."
msgstr ""

#: src/errormessages.js:34
msgid "Document cannot be renamed."
msgstr ""

#: src/errormessages.js:38
#, javascript-format
msgid "Failed to read document from storage. Please contact your storage server (%storageserver) administrator."
msgstr ""

#: src/errormessages.js:39
#, javascript-format
msgid "Save failed due to no disk space left on storage server. Document will now be read-only. Please contact the server (%storageserver) administrator to continue editing."
msgstr ""

#: src/errormessages.js:41
msgid "Document cannot be saved. Check your permissions or contact the storage server administrator."
msgstr ""

#: src/errormessages.js:42
msgid "Document cannot be renamed. Check your permissions or contact the storage server administrator."
msgstr ""

#: src/errormessages.js:47
msgid "Uploading file to server failed, file not found."
msgstr ""

#: src/errormessages.js:48
msgid "Uploading file to server failed, the file is too large."
msgstr ""

#: src/layer/marker/Annotation.js:240
msgid "Accept change"
msgstr ""

#: src/layer/marker/Annotation.js:245
msgid "Reject change"
msgstr ""

#: src/layer/marker/Annotation.js:254
msgid "Open menu"
msgstr ""

#: src/layer/marker/Annotation.js:275 src/layer/tile/TileLayer.js:243
msgid "Reply"
msgstr


// Licensed to the .NET Foundation under one or more agreements.
// The .NET Foundation licenses this file to you under the MIT License.
// See the LICENSE file in the project root for more information.

using System.Reactive.Concurrency;
using System.Reactive.Disposables;
using System.Threading;
using System.Threading.Tasks;

namespace System.Reactive.Linq
{
    public partial class AsyncObservable
    {
        public static IAsyncObservable<TSource> TakeUntil<TSource, TUntil>(this IAsyncObservable<TSource> source, IAsyncObservable<TUntil> until)
        {
            if (source == null)
                throw new ArgumentNullException(nameof(source));
            if (until == null)
     Grigory Levin

Grigory Mikhailovich Levin (; 10 January 1902  26 January 1983) was a Soviet Army colonel and a Hero of the Soviet Union. Levin served as a Red Army officer in the late 1920s and fought in the Sino-Soviet conflict of 1929. He was demobilized in 1932 and worked as a statistician. Levin was called up again after the German invasion of the Soviet Union. He served with the 385th Rifle Division and the 354th Rifle Division, in which he led a regiment. He was seriously wounded in January 1944 and upon recovery became a regimental commander in the 37th Guards Rifle Division. Levin was awarded the title Hero of the Soviet Union for his leadership of the regiment in the Battle of Berlin. Levin retired from


and *858 after a conference with Division counsel and counsel for United Fruit, this Court entered an amended impounding order on May 23, 1961, directing that documents impounded in the custody of the Division or of the Clerk of this Court be held by them in confidence, as more specifically provided therein, and subject to further order of the Court. Thereafter, at the request of Division counsel and counsel for United Fruit, I examined several hundred documents and gave my opinion whether United Fruit might properly refuse to produce them on the ground of privilege. In the Spring of 1962 the Division decided not to request an indictment in the District of Maryland, but to seek an indictment on the West Coast, and the late Judge Chesnut dischargedreal-time basis, onto the recording area of the DVD-RW. The management information associated with the video data and the audio data is temporarily recorded onto a predetermined area of the DVD-RW.
Specifically, when recording a television broadcasting program on the DVD-RW by a DVD recorder, the video data and audio data constituting the program are recorded on the DVD-RW as one or a plurality of VOBs on the real-timebasis. When the recording of that program is ended by the user's instruction, a VTSI which is the reproduction control information necessary to reproduce the recorded VOBs is recorded. Thus, the program is recorded on the DVD-RW disc as a single title including one or a plurality of VOBs, the VTSI, and backup information of the VTSI.
However, until the user finalizes


"We welcome any women that come in from the outside," she said. "It doesn't matter where they come from, from 14th Street to Cambodia. Wherever they come from, we are here to welcome them and make sure we can give information that will help them make it through the day, even if it's only sitting here listening."

I asked Evelyn how much of her own life she shared.

"My story's an open book," she said. "I don't hide myself. But I don't sit there and throw myself all out there. If somebody comes and they're going through the motions — and if I can say something from my story to help them to just hold on one more day — then I don't mind revealing myself. But I'm not goingAppellee

   On Appeal from the 276th Judicial District Court
               Marion County, Texas
              Trial Court No. F13868

     Before Morriss, C.J., Carter and Moseley, JJ.
      Memorandum Opinion by Justice Moseley
                                   MEMORANDUM OPINION

       Isaiah Luera appeals his conviction by a jury for two counts of aggravated sexual assault of

a child. The State alleged,


Jiggle Those Juicy Booties

This picture has made me revisit one of my favorite whores, Sasha Grey, and her most beautiful ass. Her slutty friend has a nice dumper on her too. One on my face and one on my lap would make this the best morning ever.is not under consideration.

“Anything we would do for one group of kids, we would do for all of the kids. And it’s just not feasible to think that they’re all going to head off to college when they’re getting out of high school, particularly with the kids from the international region,” he said. “It’s just not something we feel is necessary for us to be thinking about when they’re 12 or 13 years old.”

Little League does not charge admission for games at the World Series, but officials do solicit donations while passing around cans during games.

“Whatever money they’re getting, they’re looking for more,” said Ellen Siegel, affiliated with the team from Philadelphia.

But Keener said the $25 million a year pales in comparison to organizations such as the Boys


Places

Monica Crawford is Zero Balancing practitioner as well as an educator who works in the Bennington school district. Zero Balancing (ZB) is powerful touch therapy for both the body and the mind. ZB is a hands-on, body-mind therapy based on both western physiological science and eastern energy healing traditions, it is holistic and non-invasive. ZB Read more [...]move on.’”

Asked if it was particularly disappointing seeing Clinton lose as someone who has broken barriers for women in politics, Pelosi listed off the things Democrats could have passed if Clinton had won and Democrats retook the Senate: the Equality Act, a bill banning LGBTQ discrimination in employment and housing, an infrastructure investment bill, immigration reform and gun safety bills.

“I just don’t like missed opportunities,” she finally said. “I just thought that was such a missed opportunity for our country.”

And just like that, she was back in strategist mode.

“Having said that, we don’t agonize, we organize. We get moving to make sure the public knows what’s at stake in the policy decisions and then go to the next step, which is hopefully try to do some things together,”


in Andorra becomes a fiscal resident; however the minimum requirement for passive residency is 90 days. Each resident needs to consider the question of fiscal residency and their own personal circumstances. The times when you could avoid paying any tax anywhere are over.

The most important factor notwithstanding that a double taxation treaty may or may not exist with a third country is that any tax paid already to that third country is 100% allowable against any tax obligation in Andorra, and as Andorra invariably has the lowest rate of 10%, no tax may ever be legally payable in Andorra. Furthermore as and when Andorra signs the double taxation treaties as a resident here the 10% rate is going to be a lot less than most if not all     }
        else if (offsetZ != 0 && i % 3 == 2)
        {
            attrib.vertices.at(i) = attrib.vertices.at(i) - offsetZ;
        }
    }

    // Find out the greatest distance of three axis
    float greatestAxis = maxX - minX;
    float distanceOfYAxis = maxY - minY;
    float distanceOfZAxis = maxZ - minZ;

    if (distanceOfYAxis > greatestAxis)
    {
        greatestAxis = distanceOfYAxis;
    }

    if


identical to Zimmer's. To quote Philip J. Sampson in 6 Modern Myths about Christianity & Western Civilization, pp. 36-38,

The fact is that during Galileo's lifetime there was insufficient evidence to show that the earth revolves. This is now widely accepted by scholars, some even suggesting that the then-known facts weighed heavily against Galileo.
...
Far from being constantly harried by obscurantist priests , he was feted by cardinals, received by Pope Paul V and befriended by the future Pope Urban VIII who, in 1620, wrote an ode in his honor. The historian Georgio de Santillana observed in 1958 that "it has been known for a long time that a major part of the Church intellectuals were on the side of Galileo, while the clearest opposition to him came from secular- (985 - 980)).
21
What is -6 + -3 + -14 + (-28 - -32)?
-19
Calculate 14 + 0 + (133 - 135).
12
What is the value of -68 - -37 - -34 - (1 - 12)?
14
What is the value of (-24 + 0 - -17) + -19 + 4?
-22
What is the value of (3 + -7 - 0) + 3 - (155 + -148)?
-8
Evaluate -24 - (-22 + (14 - 4)).
-12
What is the value of -24 - (-31 + 13) - -23?
17
Calculate -38 + 13 + 16 - (4 + 0).
-13
Calculate (-7 + (4 - -8) - (-2 - 0)) + -22.
-15
What is (23 - 21 - (-2 - 5)) + -36?
-27
Evaluate -6 + (-13 - 15) - (7 - 9).
-32
What is the value of -39 + (28 - (7


As an Infrastructure-as-a-Service provider, Bluelock sees a lot of migration of applications. Migration is occurring from physical servers to cloud, from private cloud to public cloud and back to private cloud from public cloud.

Migration can be tricky and a poor migration strategy can be responsible for costly time delays, data loss and other roadblocks on your way to successfully modernizing your infrastructure.

While each scenario is different, I'd like to identify three key best practices that will help your team create a solid, successful plan for migrating your application.

Even before you begin to move your application, there's a lot of best practice that goes into choosing which application to migrate to the cloud. Regardless of whether you are migrating that app to a public cloud or a private cloud,an application it should have a lower data gravity.

When moving tier one applications from a physical datacenter to a private or public cloud, we have to take data gravity into account because it will impact the migration.

As you are talking about migrating an application, you can think of the full stack of components as a single VM or a group of VMs that are a vApp (see Figure 1).

Think of a VM with an OS. If we were to migrate that entire VM to the public cloud, we're copying anywhere from 8-20 GB of data with that OS for no reason at all as the cloud you're migrating the app to might already have the OS available to it.

Rather than transferring the data for the OS, whenever possible


use metadata instead to describe what OS you want and the configurations using a template or an image on the public or private cloud side. The same metadata concept can be applied to middleware instances too.

What we're left with is our actual data and what the app is. The app is static and static info is easy to move because you can copy it once. There's no need to replicate.

The most difficult part of the migration is the data, however. There's no easy way to shrink down the data, so you need to evaluate the weight of the data in the app you're considering migrating.

Especially if you're a high transaction company, or if it's a high transaction application, as that would be a lot of data to replicate.Hero saves family

A Springfield man pulls children from a death-defying wreck

By Brandon Mattingly

Tuesday, February 5, 2013 at 10:41 am

On Saturday, Jan. 5 at around 5 p.m., Springfield native Christy Dye, now of Lebanon, was traveling down KY 555 in her 2008 Kia Sportage chatting with passengers Tina Cocanougher (her mother) and Mary Riley (her grandmother) on their way to see Cocanougher’s sister in Willisburg.

If you subscribe to the newspaper, you receive FREE access to all the exclusive content of the web site! Simply register to receive uninterrupted access to our award-winning and in-depth local online content!

Renew Current or Past Subscription / Register for Online Subscription

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}

That code isn't very clear, since it's intimately tied to not just the representation but the way deletion works. (This is technically true of the previous code as well, although it simply seems more natural, as, for example, 'process' could free up the memory referenced by 'cur' as well, so the "early dereference" makes sense for that.) Showing that the above loop terminates is complicated, since it depends on the fact that each iteration either increases i or decreases n; this is more apparent in the following code:

i = 0; while (i < n) if (process(&array[i]) array[i] = array[--n]; // delete i by moving n-1th element over it else ++i;

Ok, so that's a little gross, but it works, it's fast and efficient, it's not that hard to understand.is explicit in the code, with n active iterations, there's an extra O(n) cost to delete. Since most programs use an effectively constant number of iterations (i.e. it's normally controlled by code, not data), this is unlikely to be very expensive. (A recursive routine could have a lot of active iterators, though.)

Note that this isn't quite correct, as it stands--during processing, if the current item is deleted, the iterator is advanced, and then after processing the the item, the iteration loop advances again, skipping an item. To use the above code correctly, the generic iteration loop must be revised to:

Iterator i = iteratorInit(coll); while (!iteratorDone(i)) { Item *item = iteratorItem(i); iteratorAdvance(&i); process(item); }

If the implementation implements insertion at the front only, the linked-list code combined with the above


be added to the missed-items queue. It is possible for items to be deleted from it. This can cause bugs if the item deleted is the item currently being reported by the iterator, so I simply suppress such deletions (from the missed-items queue--the item is still deleted from the data structure proper).

You might wonder why I go to so much work to implement the "efficient" delete, when the delete is O(n) anyway due to the need to search. For one thing, the search is very fast, and the copying around (i.e. moving all the items in an O(n) delete) would not be. Furthermore, as you will see, handling the delete this way provides most of the technology for the next two data structures as well.

This is not athe item last reported by iteratorItem before calling iteratorAdvance . (In other words, immediately after calling iteratorAdvance but before calling iteratorItem , all deletions are safe). It may or may not be illegal to delete other items or to make insertions.

advances the iterator so that will report a new item. It is illegal to delete the item last reported by calling . (In other words, immediately after calling but before calling , all deletions are safe). It may or may not be illegal to delete other items or to make insertions. iteratorDone returns whether the iterator is exhausted, that is, whether iteratorItem will report a valid item.

Efficient, Robust, Ordered Iterators

The symbol tables considered so far all have had O(n) get operations. (Well, I did do some handwaving about


should not be reported again. Thus, the index must be left at '3', which is now 'F'. Inserting either an 'E' or a 'D' is acceptable, since these will be inserted at index 3--but should the iterator advance or not? It's ok if the iterator points at 'D' or 'E', but it's also ok to advance it in this case.

The answer here is subtle, but simple. Suppose we pick the semantics that inserting at the current location does not advance the iterator. This apparently means "it's acceptable to produce on iteration an item which is inserted between the last item produced, and the next item about to be produced." This sounds like legitimate semantics, but it's an incorrect statement of what happens.

Consider the array "ACEF". 'A' and 'C'pathways. Therefore, combination drug therapy does not solve the problem.
Although the mechanisms are not completely clear, the best documented and clinically relevant mechanism for multidrug resistance in tumor cells is correlated with the expression of P-glycoprotein, the product of the MDR1 gene. P-glycoprotein is a broad specificity efflux pump located in the cell membrane, and functions by decreasing the intracellular accumulation of many lipophilic cytotoxic drugs, including some widely used anticancer agents such as anthracyclines, vinca alkaloids, epipodophyllotoxins, actinomycin D and taxol, thereby rendering cells resistant to these drugs (Pastan et al., 1991).
In addition to MDR1, another pleiotropic drug transporter has then been discovered (Grant et al., 1994). This protein, termed the Multidrug Resistance-associated Protein (MRP), has been shown to confer a pattern of resistance to cytotoxic drugs,


Introduction
============

Since World War II, food insecurity has been an issue concerning the world's poorest, with the received wisdom being that such insecurity could be alleviated by eliminating local poverty ([@ref-15], [@ref-15]) and improving food distribution since, globally, food has historically been produced in excess of world population needs. However, future food and nutritional security has become a major concern for both rich and poor, given the present concurrence of rising human population, climate change and changing consumption habits ([@ref-22], [@ref-22]). This new reality has been recognised ([@ref-11], [@ref-11]; [@ref-23], [@ref-23]; [@ref-8], [@ref-8]), with attention now being paid to provision of the full range of nutrients in addition to calories, and to the development of metrics describing food system resilience on an economy-by-economy basis. [@ref-4] ([@ref-4]) recognised that oneand irrigation water for high levels of crop growth. Under these conditions, some biomass production occurs in every month of the year. We chose this cropping framework **as an example** because reliable productivity (dry matter yield per unit area) estimates are available, but our analysis can be applied to any set of agroecological conditions in which crop yields are known. Our baseline for comparisons of the calorific content and nutritional value of different food production systems is an arable cropping system that produces only high-protein milling wheat for bread production. The assumptions we make of the baseline production system are:

1.  Use of a wheat cultivar from which a high yield of flour suitable for manufacture of bread is possible;

2.  Late-autumn sowing to achieve maximum grain yield;

3.


                             22.33                          24.27

Cereals are the predominant sources of human foodstuffs, but are poor sources of protein: to obtain sufficient lysine from them, a considerable excess of dietary energy must be consumed. It has been suggested ([@ref-29], [@ref-29]; [@ref-10], [@ref-10]; [@ref-7], [@ref-7]; [@ref-4], [@ref-4]) that by combining ingredients derived from a number of plant sources, deficiencies in the protein quality of particular crop products can be corrected. Under the agroecological conditions described, the most productive cropsBut until such effects would be found and the standard QM Hamiltonian can be regarded well established, we must inspect in detail observer properties in search of collapse.

In chap. 2 we describe our measurement model in detail. We argue that collapse description demands to change standard QM formalism and propose the particular variant of its modification. In chap. 3 we’ll discuss $gedankenexperiments$ which help to interpret our formalism and discuss its meaning. In chap. 4 physical and philosophical implications of this results and interpretation discussed.

Here it’s necessary to make some technical comments on our model premises and review some terminology. In our model we’ll suppose that MS always can be described completely (including Environment E if necessary) by some state vector $|MS\rangle$ relative to $O'$ or by density


state in event $n$ differs from statistical state (\[AA3\]) and is equal to : $$\rho^m_n=|O_l\rangle \langle O_l|| s_l\rangle\langle s_l|$$ with arbitrary, random $l(n)$ which in standard QM objectively exists in event $n$, but can be initially unknown for $O$ $\cite {Bre}$. Its restricted state is $R^n_O=|O_l\rangle \langle O_l|$ and so differs always from $R_O$ of (\[AA4\]). Due to it main condition of Breuer Theorem violated and so this theorem isn’t applicable for this situation and $O$ can differentiate pure/mixed states ’from inside’. It means that the restricted states ansatz doesn’t prove the collapse appearance in standard QM formalism even with inclusion of observer quantum effects in the measurement models. The analogous conclusions follows from the critical analysis of Witnessing interpretation $\cite {Koch,Lah}$. As we noticed already statistical restrictedfitting most of QM data, and so QM states set modification isn’t unthinkable in principle. Such attempts were published already and most famous is Namiki-Pascazio many Hilbert spaces formalism [@Nam]. In standard QM formalism all its states manifold representations are unitarily equivalent, but observers interactions and evolution aren’t considered in it. It will be shown that our new formalism in some sense is analog of the nonequivalent representations of states manifold. Analogous superselection systems are well studied for nonperturbative Field theory (QFT) with infinite DF number $\cite {Ume}$. This approach was applied for measurement problem, but it’s not clear its applicability for finite systems $\cite {Fuk,May3}$.

Remind that experimentalist never observes state vector directly, but his data consists of individual random events like detector counts and the state vector


$O$ percepts only $O_j$ component of complete state vector $\Psi_{MS}$ and it’s not clear why other components aren’t observed. The tempting explanation can be related to Breuer theorem result which shows that $O$ selfmeasurement is always noncomplete. It’s possible to assume that in individual event $O$ can percept only random part $O_j$ of his effective physical state. Thus $V^O(n)$ information loss can be regarded as the consequence stochastic degeneration of $\Psi_{MS}$ and to get more clear picture one should consider statistical state $R_O$. But it also doesn’t give complete MS description as was shown in Breuer papers $\cite {Bre}$. In addition remind that S initial state vector describes $Q$ fundamental uncertainty for $O$ i.e. its subjective information on S. When S-$O$ interacted corresponding $O$ internal DFs excited andWorkshop, Dubna, 2000 (to appear in proceedings)

London F., Bauer E. La theorie de l’Observation (Hermann, Paris, 1939)

Y.Aharonov, T.Kaufherr Phys. Rev. D30, 368 (1984)

A.Whitaker, J. Phys., A18 , 253 (1985)

J.S.Bell, Helv. Phys. Acta 48, 93 (1975)

[^1]: E-mail    maybur@sgi.lpi.msk.su


on how effectively these SCFAs enter the epithelial cells \[[@B14]\]. As SLC5A8 is a high-affinity transporter, its contribution to the cellular entry of SCFAs is negligible when the luminal concentrations of SCFAs are in millimolar range as occurs when dietary fiber intake is optimal. Under these conditions, low-affinity transporters for SCFAs such as the monocarboxylate transporter MCT1 (SLC16A1) are primarily responsible for the entry of SCFAs into colonic epithelium \[[@B13]\]. Luminal concentrations of SCFAs are decreased when the dietary fiber intake is low; under these conditions, the high-affinity transporter SLC5A8 becomes important for the entry of SCFAs into colonic epithelium \[[@B13]\]. This has been demonstrated convincingly using *Slc5a8*-null mice. With optimal fiber content in diet, there is no difference between wild-type mice and *Slc5a8*-null mice in the outcomeFF-diet when compared with mice fed the FC-diet; this was true in both wild-type mice and in the *Slc5a8*-null mice ([Figure 3(b)](#fig3){ref-type="fig"}). The abundance of *Bacteroidia*, which belongs to the *Bacteroidetes* phylum, decreased in wild-type mice when fed the FF-diet instead of the FC-diet, but the decrease was evident in *Slc5a8*-null mice independent of the fiber content in the diet when compared with FC-fed wild-type mice.

We performed indicator species analysis (ISA) to monitor bacterial species that are unique within a given Slc5a8 genotype and within a given dietary fiber condition. This analysis determines bacterial OTUs that are significantly associated with a given condition (*P* \< 0.05) based on fidelity (exclusivity) and relative abundance of the organism. First, we compared wild-type mice fed the FC-diet with wild-type mice fed


blot in the mucosal scrapings from the four groups of mice. HIF-1*α* levels decreased both in wild-type mice and in *Slc5a8*^−/−^ mice fed the fiber-free diet ([Figure 8(b)](#fig8){ref-type="fig"}). With the fiber-containing diet, HIF-1*α* levels decreased in *Slc5a8*-null mice compared with the wild-type mice.

4. Discussion {#sec4}
=============

4.1. Influence of Dietary Fiber and Slc5a8 on Microbiota {#sec4.1}
--------------------------------------------------------

Diet, gut microbiota, and host genetics are important factors for healthy living \[[@B25]\] and intestinal epithelium, primarily in the colon, is the site for interaction between diet, microbiota, and host \[[@B26]\]. Pathogenesis of IBD is driven by a multifactorial process, and one of the widely accepted causative factors is microbiota dysbiosis (i.e., alterations in the bacterial composition). Published reports have shown that dietary components influence the microbiota, and that microbiota in turn influences the epithelialShinsen Shōjiroku

is an imperially commissioned Japanese genealogical record. Thirty volumes in length, it was compiled under the order of Emperor Saga by his brother, the Imperial Prince Manta (万多親王, 788–830). Also by Fujiwara no Otsugu and Fujiwara no Sonohito et al. It was initially completed in 814, but underwent a revision to be recompleted in 815.

Contents

The record contains genealogical records for 1182 families. It categorizes these by their family roots:
 imperial ancestry: 335 families
 divine ancestry: 404 families; of which 246 were of direct heavenly descent, 128 were of heavenly cadet descent, and 30 of earthly divine descent.
 foreign: 326 families; of which, 163 were from China, 104 from Baekje, 41 from Goguryeo, 9 from Silla, and 9 from Gaya.
The above categories were further subcategories by their present


The total antioxidant capacity (T-AOC) at the concentrations of 1/4, 1/8 and 1/16 LC50 increased significantly at 1 d or 2 d respectively, whereas it decreased gradually until the end of the experiment under the concentrations above 1/4 LC50. The oxidative stress products malondialdehyde (MDA) and hydrogen peroxide (H2O2) in serum increased significantly at each concentration except H2O2 at concentration of 1/16 LC50. Additionally, the micronucleus (MN) frequency of haemocytes increased at the concentrations of 1/4, 1/2 and 1/1 LC50 throughout the exposure, similar trend was observed in the comet ratio and percentage of tail-DNA (%DNA) in haemocytes. These results revealed that deltamethrin had a prominent toxic effect on E. sinensis based on antioxidative response inhibition and genotoxicity that was possibly due to lipid peroxidation (LPO) induced byjaundice, dark urine, pruritus or tender abdomen.

Exacerbation of myasthenia gravis

Fluoroquinolones, including levofloxacin, have neuromuscular blocking activity and may exacerbate muscle weakness in patients with myasthenia gravis. Postmarketing serious adverse reactions, including deaths and the requirement for respiratory support, have been associated with fluoroquinolone use in patients with myasthenia gravis. Levofloxacin is not recommended in patients with a known history of myasthenia gravis.

Vision disorders

If vision becomes impaired or any effects on the eyes are experienced, an eye specialist should be consulted immediately (see sections 4.7 and 4.8).

Superinfection

The use of levofloxacin, especially if prolonged, may result in overgrowth of non-susceptible organisms. If superinfection occurs during therapy, appropriate measures should be taken.

Vascular disorders

Epidemiologic studies report an increased risk of aortic aneurysm and dissection after intake of fluoroquinolones, particularly in the older


foreman and another card prepared showing the nature of the repairs required.
*255 The box car was 40 feet, 6 inches in length inside; on each side was a 6-foot door. From the door frame to the nearest end of the car inside was 17 feet, 3 inches. The floor was broken so that there was a hole "just inside the door and a little bit to the right," one foot from one of the door frames toward the end of the car. The hole was 12 to 15 inches wide, 18 to 27 inches long. There was nothing to prevent the hole from being seen by anyone who looked in that direction. Both 6-foot doors were wide open. The day of the accident was a clear dry Octoberof 1.82, which was not statistically significant (P = .16). Seven of these 8 prostate cancer deaths occurred among nonwhite males, who showed an SMR of 2.47 (P = 0.53). However, only 1 prostate cancer death was seen among workers specifically assigned to the MEK units. The remaining deaths occurred among maintenance workers who had lube oil department-wide assignments. This cancer risk increased with increasing duration of employment in the lube oil department. A latency of 20 years or more was also observed for these prostate cancer deaths. In this study the processing of lubricating oils was found to be at least as important as the MEK solvents, and department-wide maintenance workers were as much at risk as the MEK unit workers. In view of this finding and


Niagara-on-the-Lake

Niagara-on-the-Lake is a town in Ontario, Canada. It is located on the Niagara Peninsula at the point where the Niagara River meets Lake Ontario, across the river from New York, United States. Niagara-on-the-Lake is in the Niagara Region of Ontario, and is the only town in Canada that has a Lord Mayor. It has a population of 17,511 (2016).

Niagara-on-the-Lake is important in the history of Canada: it served as the first capital of the Province of Upper Canada, the predecessor of Ontario, called Newark from 1792 to 1797. During the War of 1812, the town, the two former villages of St. David's and Queenston, and Fort George were the site of numerous battles following the American invasion of Upper Canada, and the town was razed. Niagara-on-the-Lake is homeof War of 1812 sites which, collectively, are managed by Parks Canada under the name Niagara National Historic Sites. That administrative name includes several national historic sites: Fort Mississauga, Mississauga Point Lighthouse (1804, the first on the Great Lakes), Navy Hall, Butler's Barracks, and Queenston Heights.

Niagara-on-the-Lake features historical plaques. Critical battles in the defence of Upper Canada took place here, and at nearby at Queenston and St. David's, both now part of Niagara-on-the-Lake. In one of these, Laura Secord gained her fame.

The town gave many African-Americans their first taste of freedom, both as a stop on the Underground Railroad for those travelling further into Upper Canada, and as a refuge in its own right. Its stock of Regency and Classical Revival buildings, considered the best in the country


if(m_credentialHasBeenSet)
  {
   payload.WithString("Credential", m_credential);

  }

  if(m_enabledHasBeenSet)
  {
   payload.WithBool("Enabled", m_enabled);

  }

  if(m_hasCredentialHasBeenSet)
  {
   payload.WithBool("HasCredential", m_hasCredential);

  }

  if(m_idHasBeenSet)
  {
   payload.WithString("Id", m_id);

  }

  if(m_isArchivedHasBeenSet)
  {
   payload.WithBool("IsArchived", m_isArchived);

  }

  if(m_lastModifiedByHasBeenSet)
  {
   payload.WithString("LastModifiedBy", m_lastModifiedBy);

  }

  if(m_lastModifiedDateHasBeenSet)
  {
   payload.WithString("LastModifiedDate", m_lastModifiedDate);

  }

  if(m_platformHasBeenSet)
  {
   payload.WithString("Platform", m_platform);

  }

  if(m_versionHasBeenSet)
  {
   payload.WithInteger("Version", m_version);

  }

  return payload;
}

} // namespace Model
} // namespace Pinpoint
} // namespace Aws
is primarily for the legal team to discuss the due
diligence process.

The call-in number for the 3:00 p.m. (Houston time) Sunday call is:

 888-422-7128
 Code:  835002

The purpose of this call is to review the results of the due diligence
process and prepare summaries and recommendations to be discussed at the 7:00
meeting.

The call-in number for the 7:00 p.m. (Houston time) Sunday meeting is:

 888-422-7101
 Code:  337268

The purpose of this call is to report the results of the due diligence
investigation and make appropriate recommendations regarding the open PG&E
positions.

The legal team will be meeting in conference rooms on 38 over the weekend.  I
understand that the 7:00 meeting will be held in EB3321.

Please call if you have any questions.

Travis McCullough
Enron


series for the Samsung Galaxy Note 8 phone. In the first ad, Norman is asked by reporters about a picture he posts on Twitter that shows Bryant's hands replaced with sticks of butter and a picture in which he says "I'm Better Than Dez Bryant." Dez Bryant responded with his own commercial, where he says he's taking the high road when talking about Norman but draws Norman on a snail using the phone, indicating he's slow, and another drawing of the Redskins cornerback as a blanket, meaning Norman can't cover him.

Season-by-season results

References

External links

Category:National Football League rivalries
Category:Dallas Cowboys
Category:Washington Redskinsa very strict rigor of discipline on EDSA's buses.

By corralling the city buses onto the yellow bus lanes and preventing any overtaking, the PUB drivers were forced to wait until the line moved. More importantly, Nebrija's video also exposed the fact that there are too many city buses in relation to the actual demand. This was evident with the number of buses that are not fully occupied, as narrated by the MMDA's EDSA traffic chief.

He said they'll have to discuss the matter of bus dispatching to prevent issues regarding the excessive number of buses.

All we can say is that we hope the MMDA continues this very by-the-book enforcement of rules on drivers, public utility and private alike. Judging by yesterday's results, such an approach can have very positive


rewrite this in terms of functions:

$$A({\pmb k})= \sum_{i=1}^{N}q_i \cos{({\pmb k}\cdot {\pmb
r}_i)} \ ,$$

$$B({\pmb k})=- \sum_{i=1}^{N}q_i \sin{({\pmb k}\cdot {\pmb r}_i)} \ ,$$

$$\label{sum1}
C({\pmb k})= \sum_{m=1}^{N_i} \sum_{i=1}^{N} \gamma^m q_i \left[ \cos{({\pmb k}\cdot {\pmb r}^+_{im})} + \cos{({\pmb k}\cdot {\pmb r}^-_{im})} \right]$$

and

$$\label{sum2}
D({\pmb k})=- \sum_{m=1}^{N_i} \sum_{i=1}^{N} \gamma^m q_i \left[ \sin{({\pmb k}\cdot {\pmb r}^+_{im})} + \sin{({\pmb k}\cdot {\pmb r}^-_{im})} \right] \ .$$

The electrostatic energy then becomes, $$\begin{aligned}
\label{U_long}
U_L = \sum_{{\pmb k}}\frac{2\pi}{\epsilon_w V |{\pmb k}|^2}
\text{exp}(-\frac{|{\pmb k}|^2}{4\kappa_e^2}) \times \nonumber \\
\left[A({\pmb k})^2 + B({\pmb k})^2 + A({\pmb k}) C({\pmb k}) + B({\pmb k}) D({\pmb k})\right] \ .\end{aligned}$$ The terms in Eqs.  and , are multiplied by the $\gamma^m$ parameter, leading to a converging sum for realistic $\gamma<1$ parameter values. However, we do not know [*a priori*]{} a minimum number of images necessary to obtain an accurate result for thelong-range potential. For example, we find that for $\gamma\approx 0.9$, we need $N_i=50$ to obtain a good convergence. However, such a large number of images makes simulations extremely slow. We note, however, that Eqs.  and can be rewritten as, $$\begin{aligned}
C({\pmb k}) = \sum_{i=1}^{N} q_i \left[ c_1({\pmb k}) \cos{(k_x x_i+k_y y_i)} \cos{(k_z z_i)}\right. +\nonumber \\
\left. c_2({\pmb k}) \sin{(k_x x_i+k_y y_i)} \sin{(k_z z_i)}\right]\end{aligned}$$ and $$\begin{aligned}
D({\pmb k})= - \sum_{i=1}^{N} q_i \left[ d_1({\pmb k}) \sin{(k_x x_i+k_y y_i-k_z z_i)}\right. +\nonumber \\
\left. d_2({\pmb k}) \sin{(k_x x_i+k_y y_i+k_z z_i)}\right] \ .\end{aligned}$$

where, $$c_1({\pmb k})=2\sum_{m=1}^{N_i}\gamma^m \cos{(m k_z L)} \ ,$$ $$c_2({\pmb k})=2\sum_{m=1}^{N_i}(-1)^{m+1}\gamma^m \cos{(m k_z L)} \ ,$$ $$d_1({\pmb k})=2\sum_{m_o=1}^{N_i}\gamma^{m_o} \cos{(m_o k_z L)} \ ,$$ $$d_2({\pmb k})=2\sum_{m_e=2}^{N_i} \gamma^{m_e} \cos{(m_e k_z L)} \ ,$$ and $m$ are integers: $m_o$ are odd and $m_e$ are even. The parameters $c_1({\pmb k})$,


to calculate $W(z)$.[]{data-label="fig2"}](fig2.eps){width="7cm"}

The correlational and charge-image contribution $W(z)$ can be calculated approximately as follows. Consider $N_+$ ions (per Å$^2$), with charge $Q$ and $N_-$ ions (per Å$^2$) with charge $-Q$, all with hydration radii $r_c$, confined between two neutral dielectric walls with separation $L$, see Fig. \[fig2\]. Due to the hardcore repulsion of ions from the surfaces, they are restricted to the region $z>r_c$ and $z<L-r_c$. To keep the charge neutrality of this region, we introduce a uniform neutralizing background charge density $-Q N_c/(L-2 r_c)$, where $N_c=N_+-N_-$. In the exterior regions $z<0$ and $z>L$ the dielectric constant is $\epsilon_o$, while in the interior region it is $\epsilon_w$. The function $W(z)$ then corresponds, approximately, to the energy penalty that an ion located at a distance $z$ from one of thepaper we developed a new simulation approach to study electrolytes and ionic liquids in a dielectric slab geometry. The method is easy to implement and is comparable in time consumption with the regular 3D Ewald summation method. In the weak coupling limit we also presented a mean-field theory which allows us to predict the ionic distribution between the dielectric charged plates. The agreement between both approaches, theoretical and simulational, is very good, validating both methods. Examples of ionic density profiles for strongly correlated systems are also presented. Finally, the simulation method developed here can be used to explore the interactions between colloidal particles with strong dielectric contrast. This will be the subject of the future work.

Acknowledgments
===============

This work was partially supported by the CNPq, INCT-FCx, and by the US-AFOSR


" And he shouldn't have kept it." " He's kept all your letters." "I was very chewed and understand Green Knowe." "She's come from something very different." " Anyway it's no material now." " Why?" " l don't think I should be here much longer." " Why?" "What's happened?" "Nothing, but the world is changing, that's all." " l don't think I have enough money to stay." " You can't sell it." " l may have to." " But it's never been sold." "It's never been sold to now." "It's come close a few times." "She brought us right to the brink." "Mrs. Thomas Oldknow?" "Why you?" "Hardly." "It's Maria van Raymer." "She's Dutch, grew up in India." "She married Captain Oldknow in Calcutta then he brought herThey did." "They had a son, called Sefton  And a daughter, called Susan." "And you descend from Sefton." "What a funny name." "I don't think someone called Toseland is in much of position to talk." " Was Sefton nice?" " No, he was selfish and spoiled." "The door in the dining room, with the brick wall behind it" " Was it out the way to Mariah's wing?" " It was." "You might like this." "It was your father's." "I made the pyjamas when David had whooping-cough." "So they could both have whooping-cough together." " l am so old for that really." " Yes, I know." "I thought ot might interest you to know it was his." " Was Susan spoiled and selfish like her brother?" " No,


" l want my bird, I'm tired of wating." "Don't." "It's all right. I can do it." "See, you're the on making all the fuss." " Now take her upstairs before I really lose my temper." " Come with me." "You can wait in your room." "It'Il be all right." "Faster." "Robert, light the fire." " That'Il speed things up a bit." " You don't have to do this, you know." " He can't force you." " What are you on man?" "Come on, don't make a... of it." "Holy god." " For two pins, I..." " You what?" "You 'd lose your place that's what." "Just pray for him, that's all we can do now." "If it isn't Lord Farrar's precious spurs." " Should someone go up"Come to bed." "And don't read too long." "You not be tired for your mother tomorrow." "Granny, can you be nice to her when she gets here?" "Please!" "You make me feel... ashamed." "Of course I'Il be nice to her." "Because we all love dad, don't we?" "All three of us." "I know he'd like to see for all getting on when he comes back." " Yes, of course, he would." " l think, she's found him." " l think, she knows where he is." " We mustn't raise our hopes up too high." " l don't think my hopes can get any higher." " No, nor mine really." " But..." " But what?" "Never mind." "We'Il cross that bridge when we come to it." " Tolly." "


believe India is in an interesting phase! India is in a crucial phase: It overhauls its economy. It reinvigorates its international engagements in order to harness its full potential as a rising power in a multipolar world. With new self-confidence, India engages its neighbourhood, re-energizes its relations to the wider world and underlines its claim as a future member of the Security Council of a reformed United Nations. India will also be a major voice at the climate summit in December in Paris.”

Germany can help India in a big way in realising its ambitious goals in such diverse areas as cleaning of rivers, upgrading infrastructure, improving air quality of Indian cities, besides lending a crucial helping hand in PM Modi’s pet schemes like Smart Cities, Skill India andOkay, so this one actually bothers me quite a deal in the Windows 8 consumer preview: the fonts in Metro look fuzzy – they look like fonts on Mac OS X. Because of the Mac OS X resemblance, I had assumed that Metro switched to a shape-accurate rendering method, like Mac OS X uses, but as it turns out, it’s a little less exotic than that.

Up until very recently, Apple and Microsoft had very different approaches to rendering fonts. Because of Apple’s presence in the publishing industry, Mac OS X focusses on maintaining the original shapes of the glyphs of typefaces, even if that means additional blurriness. Microsoft’s ClearType, on the other hand, optimises glyphs for on-screen readability, forcing them into the pixel grid. This distorts some of


Dev Engineer - Data Center Global Services at Amazon (Seattle, WA)Are you looking for an opportunity to be a part of a new, global program, building a team from the ground up? Data Center Global Services (DCGS) is looking for an experienced, high-caliber candidate to lead the design and development of world class systems and tools that will support AWS Infrastructure teams around the world.

 As the lead developer, you will drive the creation of tools enabling Data Center engineering, design, construction, and operations on a world wide scale. You should be adept and comfortable setting the technical direction for your group, guiding other members of the technical staff, and building new software services from ground up. The ideal candidate sees the big picture from allAmazon’s and an online world where threats grow ever more sophisticated requires building a world-class security team to tackle never-before-seen challenges at dizzying scales. You will not just be using cutting-edge technologies here in Amazon; you will be inventing them.
 You have strong verbal and written communication skills, are self-driven and deliver high quality results in a fast-paced environment. You have strong computer science credentials, are passionate about Internet technology, are customer-obsessed and have a track record of building quality services. You know how to build and you dive deep into back-end services. You excel when working on complex and diverse systems. You can succinctly and accurately report your findings. Most importantly, you have a passion for learning and continuous improvement.

MINIMUM 8 years' Software Development experience
<br


in media and art. Do you share our vision? We have the power of Amazon Web Services’ cloud, Twitch, Amazon eCommerce, and our digital and physical media publishing infrastructure. Are you ready to innovate and build the best game technology and bold new player experiences?

The Role:

Write quality, reusable code for modular components in a robust development environment.

Drive the architecture and technology choices that enable a world-class user experience.

Work closely with product and development management to architect the right solutions.

Have fun working on ground breaking technology with people just as passionate about their work as you!

Bachelor's degree in Computer Science or Computer Engineering (or equivalent) experience.

5+ years of professional software engineering experience, working across multi-discipline teams.

A solid understanding of client SDK design and service API design.

Strong computer science(Portland, OR)
Exciting position with a thriving organization in the music tech industry! We are seeking a full-time Software Engineer to join our growing team.

THE WORK:

Design and develop XML/XLS parsing tools for production team

Maintain a set of software tests as part of the CD/CI environment

Work closely with production team to ingest various formatted music metadata

Light system administration and management of AWS environment

Thu, 23 Jul 2015 21:29:29 Z2015-07-23T21:29:29ZPortland, ORhttp://careers.stackoverflow.com/jobs/91347/senior-backend-developer-thinairhttp://careers.stackoverflow.com/jobs/91347/senior-backend-developer-thinairThinairpythonamazon-web-servicesdjangoSenior Backend developer at Thinair (Palo Alto, CA)
We're looking for a senior backend developer to help design our product and to eventually lead our backend team.
Fri, 24 Jul 2015 18:29:29 Z2015-07-24T18:29:29ZPalo Alto, CAhttp://careers.stackoverflow.com/jobs/93706/system-administrator-devops-taptap-networks-slhttp://careers.stackoverflow.com/jobs/93706/system-administrator-devops-taptap-networks-slTAPTAP Networks S.L.amazon-web-servicesredisnginxmongodbsysadminpuppetSystem Administrator/ DevOps at TAPTAP Networks S.L. (Madrid, Spain)

AWS experienced System administrator will participate in the daily monitoring, management, troubleshooting and issue


maintaining a large environment which supports a next generation learning management system (LMS). The ideal candidate needs to have a passion for automation, configuration management, and managing scale. One must be familiar with scripting technologies, development methodologies, and working in a DevOps environment.

WHAT YOU WILL BE DOING:

Utilize configuration management frameworks to deploy and manage systems.

Help design and manage a large scale Ruby on Rails infrastructure hosted on Amazon AWS.

Develop solid relationships with infrastructure, support, QA, and development teams and use them  to improve system stability and availability.

Monitor the infrastructure and proactively scale as necessary.

On-call rotation to support operational issues.

Thu, 30 Jul 2015 16:29:29 Z2015-07-30T16:29:29ZSalt Lake City, UThttp://careers.stackoverflow.com/jobs/18663/software-engineer-platform-dataminrhttp://careers.stackoverflow.com/jobs/18663/software-engineer-platform-dataminrDataminrjavac++amazon-web-servicesnosqlSoftware Engineer Platform at Dataminr (NY, NY)
At Dataminr, wequality code and having project ownership then this is the role for you!
Fri, 24 Jul 2015 00:29:29 Z2015-07-24T00:29:29ZPortland, ORhttp://careers.stackoverflow.com/jobs/83546/devops-engineer-circle-internet-financialhttp://careers.stackoverflow.com/jobs/83546/devops-engineer-circle-internet-financialCircle Internet Financialamazon-web-servicescontinuous-deploymentjavascriptscriptingsysadminDevOps Engineer at Circle Internet Financial (Boston, MA)
Are you interested in building the future of money? At Circle, we're transforming the world economy with secure, simple, and less costly technology for storing and using money. Our passion is bringing the best of the open Internet to consumer finance and payments.

What you will do

Evolve our build, test and deploy pipeline for circle.com and related properties using cloud based tools and best practices
Build and support tools and processes enabling rapid deployment with high availability
Fri, 17 Jul 2015 22:29:29 Z2015-07-17T22:29:29ZBoston, MAhttp://careers.stackoverflow.com/jobs/76357/senior-ruby-on-rails-developer-tonic-design-cohttp://careers.stackoverflow.com/jobs/76357/senior-ruby-on-rails-developer-tonic-design-coTonic Design Co.rubychefruby-on-railsamazon-web-servicesSenior Ruby on Rails Developer at Tonic Design Co. (Philadelphia, PA)
We are looking for a Ruby


12:29:29 Z2015-07-09T12:29:29ZMünchen, Deutschlandhttp://careers.stackoverflow.com/jobs/87739/backend-software-engineer-storehousehttp://careers.stackoverflow.com/jobs/87739/backend-software-engineer-storehouseStorehouseruby-on-railsnode.jsamazon-web-servicesgobackendBackend software engineer at Storehouse (San Francisco, CA)
Storehouse is looking for sharp, creative engineers with a desire to build beautiful software, inside and out. Our team is small and you’ll play a key role in shaping our company, our product, and our culture. Our large (and rapidly growing) community loves Storehouse, and your contributions will be critical to our growth. As a backend engineer you'll work closely with our award-winning designers and iOS engineers to build features, and you'll be crucial to the product feeling fast and reliable.

Things which describe you:

Strong background building RESTful APIs using modern tools and frameworks.

Experience managing Linux/Unix deployments and configuration with modern tools.

Experience and intuition scaling to serve lots of traffic. You can spot bottlenecks and2015 14:29:29 Z2015-07-29T14:29:29ZNew York, NYhttp://careers.stackoverflow.com/jobs/93112/devops-engineer-insidetrack-inchttp://careers.stackoverflow.com/jobs/93112/devops-engineer-insidetrack-incInsideTrack, Inc.amazon-web-servicesazureshellDevOps Engineer at InsideTrack, Inc. (Portland, OR) (allows remote)
  Our Dev Ops Engineer is responsible for overseeing, implementing, and managing the company’s strategy regarding cloud-based information technology systems and application infrastructure for in-house engineering solutions.

Responsibilities:

Works collaboratively with IT, Engineering, product/project managers, QA and other cross functional teams to deliver quality support and service on time.

Highly experienced professional, who uses professional concepts in developing resolutions to critical issues and broad design matters.

Communicates clear, concise, strategic vision, and direction of the company.

Works on project teams acting as a resource regarding technical tasks on projects.

Collaborates and partners with Engineering and Product teams.

Works with Cloud provider and external technical support on upgrades, problem resolution and design issues.

Monitors and tunes appropriate


same way as software developers. Our infrastructure is delivered with Amazon AWS across multiple regions.

This role will act as the glue between our product development and operations team. You will provide automation capabilities for build and deployment of software and environments

Establishing new DevOps processes and systems to facilitate transition of code to our production environments using best practice automation scripting (e.g. managing large development projects at varying stages)

Managing the infrastructure required to distribute build artefacts to live customer systems

Resolving any development or production deployment issues raised in JIRA

Developing and maintaining deployment tooling, working with Ansible  and Puppet

Maintaining and enhancing our Linux development and lab environments used by  MTT’s development teams

Implementing systems to automate tasks associated with the development of java andmimicking production.

Develop and maintain systems management software tools, procedures, and documentation

Develop and maintain applications, tools and scripts

System design and Configurations, and Deployment Management

Analyze system and application architecture to ensure that all requirements are met

Evaluate and select tools and technologies needed for efficient support of the systems

Automate common maintenance, deployment and build jobs

Collaborate with application developers   to ensure proper testing, configuration, and deployment

Ability to learn, implement and explain new tools and technologies quickly

Self-motivated and able to work independently with low supervision and in a team environment

Mon, 27 Jul 2015 18:29:29 Z2015-07-27T18:29:29ZCampbell, CAhttp://careers.stackoverflow.com/jobs/93425/lead-software-engineer-coupa-softwarehttp://careers.stackoverflow.com/jobs/93425/lead-software-engineer-coupa-softwareCoupa Softwareruby-on-railssaasjquerymysqlamazon-web-servicesLead Software Engineer at Coupa Software (San Mateo, CA)
We are looking for a Lead Software Engineer to help us deliver our vision.  A successful Lead Software Engineer will


developed in PHP using frameworks such as Symfony, Laravel and CodeIgniter.
Mon, 06 Jul 2015 14:29:29 Z2015-07-06T14:29:29ZDublin, Irelandhttp://careers.stackoverflow.com/jobs/92261/growth-engineer-theskimmhttp://careers.stackoverflow.com/jobs/92261/growth-engineer-theskimmtheSkimmmysqlpostgresqlamazon-redshiftmemsqlruby-on-railsGrowth Engineer at theSkimm (NY, NY)
theSkimm is a service that helps people be smarter about the things they should know. Today, theSkimm is one of the fastest-growing email newsletters on the market, with unprecedented engagement and growth. We've redefined the morning routine for female millennials by delivering news and information with a distinctive voice and format. Tomorrow, we're becoming the first company to turn news into a lifestyle brand. Our next step is developing a truly unique mobile experience that builds upon our voice and the trust we've built with our audience. We want you to be a key part of the beginning of our journey.

Our Growth Engineer Skimm'r will workclosely with our growth and engineering teams to help realize our vision for data infrastructure and business intelligence tools. This position is a three month contract-to-hire role, focused on helping us hit our growth goals for newsletter subscribers.
Thu, 09 Jul 2015 20:29:29 Z2015-07-09T20:29:29ZNY, NYhttp://careers.stackoverflow.com/jobs/87663/python-devops-engineer-stream-inchttp://careers.stackoverflow.com/jobs/87663/python-devops-engineer-stream-incStream INCpythoncassandraamazon-web-serviceslinuxsysadminPython (Devops) Engineer at Stream INC (Amsterdam, Netherlands)
About Stream

Stream (Techstars NYC'15) is building a new kind of data store. A data store to build, scale and personalize feeds. Our users access Stream via a blazing fast, highly available and simple to use API service. We run on a very complex tech stack, highly optimized for performance and availability.

We run a very well funded startup between Amsterdam and Boulder (Colorado). We are looking for an experienced Python DevOps engineer to join


on Amazon Web Services.

A track record of developing projects through the complete life cycle, with high quality and on time delivery.

Experience with Django and Python.

Experience developing scale out application architectures.

Ideally, experience with video streaming and DRM.

Disciplined work ethic, high standards, desire to excel.

Commitment to quality and customer satisfaction.

Responsibilities:

Lead the back end engineering team for the Indieflix service.

Maintain the existing service (Django/Python).

Work with our team leaders to architect the backend of the next generation service.

Be the lead engineer developing the next generation service.

Manage and mentor the other backend engineers.

Manage devops for the service.

Participate in guiding the future of the business.

Tue, 28 Jul 2015 00:29:29 Z2015-07-28T00:29:29ZSeattle, WAhttp://careers.stackoverflow.com/jobs/92399/senior-devops-engineer-or-guru-if-you-will-workivahttp://careers.stackoverflow.com/jobs/92399/senior-devops-engineer-or-guru-if-you-will-workivaWorkivaamazon-web-servicessysadminSenior DevOps Engineer, or Guru if youtop digital, CRM and mobile agencies, Wunderman delivers deeply connected brand experiences, consumer engagements, data and insights that build brands and businesses. Currently we are seeking a domain expert in the fundamental areas of Linux, Apache, MySQL, and PHP to join our Headquarters in New York City.

What you’ll be responsible for as a member of the Wunderman engineering team:

As a LAMP Full-Stack Developer you and a Senior Front-End Developer will work together towards producing engaging and immersive experiences for both high and low traffic websites. With the ability to provide technical strategy across systems, you will take full ownership of the Back-End implementation and technical architecture of the project. As the teams lead, your expertise will aid in gathering requirements that are pertinent to each build.
<br


will possess a broad range of skills to maintain and improve our AWS-based infrastructure to keep the things we build on top of it running. We have adopted a number of Agile practices in our development process in order to adapt to the fast-evolving nature of our projects and we’re looking for someone who thrives using this methodology.

The successful candidate will have a demonstrated ability to work collaboratively, to manage multiple responsibilities independently, while adhering to established departmental technology standards and best practices for back-end architecture.

This position does not include telecommuting or relocation; qualified candidates must be able to commute daily to the Brooklyn Museum. No recruiters please.
Mon, 13 Jul 2015 21:29:29 Z2015-07-13T21:29:29ZKings County, NYhttp://careers.stackoverflow.com/jobs/92955/devops-engineer-sre-vocaliqhttp://careers.stackoverflow.com/jobs/92955/devops-engineer-sre-vocaliqVocalIQpythonautomationamazon-web-servicesjenkinsagileDevOps Engineer / SRE at VocalIQ (Cambridge, UK)
We are looking for a/>
If you would like to discuss the role, technology, company or any other aspect please do get in touch.
Wed, 22 Jul 2015 12:29:29 Z2015-07-22T12:29:29ZCambridge, UKhttp://careers.stackoverflow.com/jobs/91608/sr-software-engineer-front-end-interactive-intelligence-inchttp://careers.stackoverflow.com/jobs/91608/sr-software-engineer-front-end-interactive-intelligence-incInteractive Intelligence, Inc.javascriptrestknockout.jsamazon-web-servicesSr Software Engineer (Front End) at Interactive Intelligence, Inc. (Indianapolis, IN)
Interactive Intelligence is looking for exceptional software engineers to help us build a new workforce management product that is better than the best-of-breed solutions currently out in the market. Our workforce management product will allow customers to analyze and forecast load and resource requirements, create optimal schedules, and track agent schedule adherence.

This person will design and implement web user interfaces that are functional, intuitive, and elegant. These user interfaces will be part of a new cloud-based solution that uses Javascript, Typescript, CSS, HTML, ReST services, Java, AWS, and other emergent technologies.

Major Responsibilities/Activities
<br


of registered users. Grammarly’s automated proofreader helps the world’s 2 billion English speakers improve the quality of their writing.

We are looking for a hands-on DevOps Engineer who will be responsible for writing code and building systems to improve the performance and operational efficiency of our distributed NLP and growth systems. As a DevOps Engineer with Grammarly, you will establish and support operational needs for Grammarly’s SF office, function on-call with an operations team, and provide operational tooling and support for feature delivery teams.

What You Will Accomplish

Review and design the architecture of new projects with development teams

Improve services and tools that are in production

Develop our automation and deployment strategies

Scale our data storage systems

Analyze and address performance and stability risks

Develop variousother tools to build a fast, scalable infrastructure.

Work collaboratively with developers and product to provision new services and smooth deployment processes.

When our automated tools fail to recover from infrastructure problems, respond to those problems promptly and account for them in the automation.

Requirements

Experience building highly available, scalable, and reliable solutions with both software and infrastructure.

Software development skills with good intuition for building reusable, modular code.

A passion for building scalable, fault-tolerant applications and infrastructure.

An acute sense for debugging issues quickly and comfort doing so in a production environment.

Eagerness to learn new tech stacks and move fast.

Preferred

Experience with several of the following: Puppet, Docker, Jenkins, MongoDB, Nginx, php-fpm, Redis, AWS (or other cloud providers like GCE, DigitalOcean,