                  On Error GoTo 0
'                End If

            End If
        Next

        Me.Show

    End If
End Sub
Private Function getObjFromID(ByRef WS As Worksheet, ByVal id As String) As Object
    Dim ret As Object
    Dim s As Shape

    For Each s In WS.Shapes
        Select Case s.Type
       ReportCheck strCheck, "-", WS.Name, HL.Shape.id, WB.Name
                End Select
            End If
            i = i + 1
            ReportBar i
        Next

        For Each r In WS.UsedRange
            If r.HasFormula And InStr(r.Formula, "=[") = 1 Then
                ReportCheck


Err.Number = 0 Then
            For Each s In r
                ReportCheck strCheck, s.Address, WS.Name, s.Address, WB.Name
            Next
        End If
    Next

End Sub
Private Sub checkSheetMerge(ByVal strCheckNm As String, ByVal strCheck As String)

    Dim WB As Workbook
    Dim WS As Worksheet
    Dim r As Range

    Set WB = ActiveWorkbook

    For Each WS In WB.Sheets
For i = 0 To lstContents.ListCount - 1
         Call SaveSetting(C_TITLE, "StaticCheck", CStr(i), lstContents.Selected(i))
    Next
End Sub
Private Sub MW_WheelDown(obj As Object)

    On Error GoTo e

    If obj.ListCount = 0 Then Exit Sub
    obj.TopIndex = obj.TopIndex + 3

e:
End Sub

Private Sub MW_WheelUp(obj As Object)

    Dim lngPos As Long

    On Error GoTo e

    If obj.ListCount = 0 Then Exit Sub
    lngPos = obj.TopIndex - 3

    If lngPos < 0 Then
        lngPos = 0
    End If

    obj.TopIndex = lngPos
e:
End Sub
Sub ReportCheck(ByVal strCheck


As String, ByVal strAddress As String, ByVal strSheet As String, ByVal strId As String, ByVal strBook As String)

    lstResult.AddItem ""
    lstResult.List(lstResult.ListCount - 1, C_SEARCH_NO) = lstResult.ListCount
    lstResult.List(lstResult.ListCount - 1, C_SEARCH_STR) = strCheck
    lstResult.List(lstResult.ListCount - 1, C_SEARCH_ADDRESS) = strAddress
    lstResult.List(lstResult.ListCount - 1, C_SEARCH_SHEET) = strSheet
    lstResult.List(lstResult.ListCount - 1, C_SEARCH_ID) = strId
    lstResult.List(lstResult.ListCount - 1, C_SEARCH_BOOK) = strBook

End Sub

Private Sub StartBar(ByVal strMsg As String, ByVal lngMax As Long)

    lblBar.visible = True
    lblBar.width = 0
    lblBar.Caption = strMsg

    lblStatus.Caption = strMsg
'    lblStatus.TextAlign = fmTextAlignCenter
    lblStatus.Tag = strMsg
 Blog

Sunday, 31 December 2017

As some of you know or by now have guessed, I have written two series, one the Eden Paradox, a science fiction series, and the other a spy thriller series, under the name J F Kirwan. Having finished both series, the question I find both my 'halves' being asked, is what next?

Well, as with everything about writers, rather than a simple answer, there's a story. When I finished the Eden series with Eden's Endgame, I was pretty exhausted. That series started as a short story back in 2003 (called Trouble in Eden), which by 2008 was a manuscript, and it got published (The Eden Paradox) in 2011. But let's backtrack just a moment, because in 2008 I almost got a deal for the book with


started writing a thriller with scenes borrowed from some of my scarier diving moments. It was just for fun, but I sent it out and took it to a writers conference, where it got roundly hammered. Nevertheless, I put in all the reviewers' suggestions, even one I thought was wrong and completely off-beam, and sent it out again, and got it accepted by... HarperCollins. Not only that, they wanted a three-book deal. Guess what I said?

But by now I'd started another science fiction story (I don't sleep, you know that if you read my blogs), titled 'When the Children Come', which was meant to be a prequel to a short story I wrote (actually intended as a tribute to Iain Banks) called Executive Decision. I was already aTruex Jr.), I’d put them in the top seven that are in the sport right now. So, it’s going to be tough to beat them week in and week out.”

Hamlin, 36, accomplished the feat three times last year — and nearly won a fourth race at Sonoma, where he finished .625-seconds behind former teammate Tony Stewart. En route to his first Daytona 500 win, Hamlin held off Truex by .010-seconds —the closest finish ever in the Great American Race. Busch, Kevin Harvick and Edwards rounded out the top five.

Hamlin scored his first road course win at Watkins Glen in August and earned his third Richmond victory in September. With Mike Wheeler calling the shots for the No. 11 crew, Hamlin has a renewed determination — no matter what


FACTBOX – Ties and tensions between China and Japan
REUTERS – Chinese rescuers arrived in Japan on Sunday to help search for survivors from a massive earthquake and tsunami, barely six months after Asia’s two largest economies faced off in a maritime territorial dispute.Read more on Reuters via Yahoo! India News

FACTBOX – Ties and tensions between China and Japan
Here are some facts about ties between the two countries.Read more on The Star

Historical markers show a booming industry in Orange
Orange formerly had a booming maritime industry, particularly during World War II, as these six historical marker off the intersection of Green Avenue and Simmons Drive attest.Read more on The Orange Leaderfollowed by feature extraction (calculation of band power from PSD of the remaining frequencies) from the data. The feature vector was then given as input to a logistic regression classifier network for classification of three finger movements. Based on the classification, a command signal is generated and sent to a motor drive circuitry (H-Bridge in this case) to actuate the respective motor to start the finger movement of upper limb prosthesis.

This research was carried out using data already acquired from the subjects. Data set of each trial consisted of 10 seconds of data of 14 channels at the sampling rate of 128 Hz. From each of the 47 trials, 250 ms of data was extracted and converted to text files. The data was saved offline on an SD card in


power of Power Spectral Density of Mu and Beta Rhythms was chosen as feature vectors. PSD is used as a feature vector in 70% of the research which focuses on motor controls. The periodogram of the movements was plotted for the channels above sensorimotor cortex to visualize the differences.

The development of the embedded system was focused on to design a control for upper limb prosthesis that has small size and light weight and is easy to carry onboard system for prosthesis user. The acquired data was saved on SD card rather than on the controller to depict a real time data processing and classification. 70% mean classification accuracy was achieved with 2-stage logistic regression classifier using an Arduino Uno based embedded system. It should also be noted that

  \(5\)   Testability     \(i\) In-System Programming by On-chip Boot Program\
                          (ii) True Read-While-Write Operation

  \(6\)   Response        Speed Grade:\
                          (i) 0--4 MHz @ 1.8--5.5 V\


Biophysical and molecular properties of amiloride-inhibitable Na+ channels in alveolar epithelial cells.
The recent immunopurification and cloning of various lung Na+ channel proteins has provided the necessary tools to study Na+ transport at a fundamental level across a number of epithelial tissues. Various macroscopic measurements of Na+ transport have shown that Na+ ions enter the cytoplasm of alveolar cells mainly through amiloride-inhibitable Na+ channels. Molecular biology studies have shown the existence of three Na+ channel subunit mRNAs (alpha-, beta-, and gamma-rENaC) in mature fetal (FDLE) and adult alveolar type II (ATII) cells. Patch-clamp studies have demonstrated the existence of various types of amiloride-inhibitable Na+ channels, located in the apical membranes of FDLE and ATII cells. beta-Agonists and agents that enhance intracellular adenosine 3',5'-cyclic monophosphate levels increase the open probabilitylife whilst ideas are perfect states and in this sense 'more real'. So Plato's whole philosophical program is to 'explore the world of ideas', not pragmatism at all. And yes, I'm not using "idealist" in the common sense of the word.

Socrates was executed most probably because he was challenging the established ethics. His ideas about sex in particular, including sensitive topics such as having sex with someone else's woman or homosexuality. We will never know the exact reason as Socrates never wrote a word.

— Of all the journeys you will undertake in this life, uncovering the secrets you hide from yourself is the most dangerous voyage of all.  Shyha Tuhlwin, Therish Philosopher

Actually, we don't know that for certain. He *says* that he abandoned his political career and


of the poem:

{audio}/UserFiles/File/ABOUT_US/WORKSHOPS/Poem%20native.mp3{/audio}

Photo: copyright E&M

The original text of the poem: we folded the paper so that each person only saw the final line of the stanza which had been written before theirs.it's highly relevant to most hooks).
Leave in the refs/heads/ and/or refs/tags/ prefixes: git rev-list is happy with these prefixes, and they serve to make sure that you get the right reference.  For instance, if there are both a tag and a branch named master, which one do you get?  (You get the tag—but why not use the full name, and not have to remember that?)


is difficult to detect accurately the start of a vibration pulse since the frequency of vibration gradually increases as the motor accelerates until the motor reaches a target angular speed.
Considering the underlying physics, the centrifugal force F causing vibration, for a mass element rotating about a rotational axis is:F=mω2rwherein m is the mass of the mass element, ω is the angular speed of rotation (radians per second) and r is the offset of the mass element from the rotational axis. As the equation is linear with respect to m and r, the equation can be generalized so that it refers to an infinitely small mass center of a real mass element that is not infinitely small. In this case, the mass m is the mass of the entireAthletics at the 1908 Summer Olympics – Men's 10 miles walk

The men's 10 miles walk race was held at the 1908 Summer Olympics in London. This event was held for the only time. The competition was held on Thursday, July 16, 1908 and on Friday, July 17, 1908. The competition was held in two rounds.  There were two heats in the first round, with the top four in each heat advancing to the final. 25 race walkers from eight nations competed.

Results

First round

The first round heats were held on Thursday, July 16, 1908.

Heat 1

Carter, Larner, and Spencer intentionally drew even to finish in a line. Carter had been in second place, followed by Spencer and then Larner before they did so.

Heat 2

Final
The final was held on Friday, July


Q:

How to create PDO insert statement from looped key and value array

From POST method like $uri = explode("&", $_SERVER["QUERY_STRING"]); I can retrieve the value that I need for the insertion operation. Also I have a constructor function that calls another function that returns PDO for my sqlite connection:
 private function dbConnect()
{
    try {
        $this->db = new PDO('sqlite:model.sqlite3');
        $this->db->setAttribute(PDO::ATTR_ERRMODE, PDO::ERRMODE_EXCEPTION);
    }
    catch (PDOException $e) {
        echo $e->getMessage();
    }
    return $this->db;

}

This method has been tested with GET and is ok. Now I want to insert into table new record by URI Calls:
private function   <?php foreach ($fields as $field_name => $field_display): ?>
        <th <?php if($sort_by == $field_name) echo "class=\"sort_$sort_order\"" ?>>
            <?php echo anchor("rps/index/$field_name/".
            (($sort_order == 'asc' && $sort_by == $field_name) ? 'desc' : 'asc'), $field_display); ?>
        </th>
    <?php endforeach; ?>
    </thread>

    <tbody>
        <?php foreach ($record as $key): ?>
        <tr>
            <?php foreach ($fields as $field_name => $field_display): ?>


<?php echo $key->$field_name; ?>
        <?php endforeach; ?>

    <?php endforeach; ?>

<?php if (strlen($pagination)): ?>

    Pages: <?php echo $pagination; ?>

<?php endif; ?>

controller:
    public function index($sort_by='player_item', $sort_order='asc',$offset=0)
    {

      if (isset($_POST['num']) && !empty($_POST['num']))
            $limit = $this->input->post('num');

            else
            $limit= 25;

            $data7['fields'] = array(
 rolling urgent care and the emergency room into the same department -- both to save money and streamline service -- especially as the hospital opens a costly new wing.

"Many hospitals, if they're going to be rebuilding anyway, they're deciding how health care is going to be delivered differently." She said she's seen many hospitals moving in the same direction.

Last March, St. Joseph CEO Joe Mark said in a memorandum to staff members that despite previous plans to close the urgent care clinic, the hospital would not be doing so after "members of our community raised concerns that this consolidation would potentially increase out of pocket expenses for urgent care treatment."

Last Thursday, a memorandum from Reeder went out to hospital staff, saying that after much review of patient and


       App.get('router').setAuthenticated(true);
        router.transitionTo(path + 'step' + installerController.get('currentStep'));
        break;
      case 'CLUSTER_INSTALLING_3' :
      case 'SERVICE_STARTING_3' :
        if (!installerController.get('isStep9')) {
          installerController.setCurrentStep('9');
          installerController.setLowerStepsDisable(9);
        }
        router.transitionTo(path + 'step' + installerController.get('currentStep'));
        break;
      case 'CLUSTER_INSTALLED_4' :
        if (!installerController.get('isStep10')) {
         installerController.setCurrentStep('10');
          installerController.setLowerStepsDisable(10);
        }
        App.db.data = currentClusterStatus.localdb;
        App.get('router').setAuthenticated(true);
        router.transitionTo(path + 'step' + installerController.get('currentStep'));
        break;
    }
  }

});


e.g., smart pointers,
// as readable and/or writable iterators.
template <class Iterator, class T>
void readable_iterator_traversal_test(Iterator i1, T v, mpl::true_)
{
    T v2(*i1++);
    BOOST_TEST(v == v2);
}

template <class Iterator, class T>
void readable_iterator_traversal_test(const Iterator i1, T v, mpl::false_)
{}

template <class Iterator, class T>
void writable_iterator_traversal_test(Iterator i1, T v, mpl::true_)
{
    ++i1;  // we just wrote into that position
    *i1++ = v;
    Iterator x(i1++);
    (void)x;
}

template <class Iterator, class T>
void writable_iterator_traversal_test(const Iterator i1, T v, mpl::false_)
{}

// Preconditions: *i == v
template <class Iterator, class T>
void readable_iterator_test(const Iterator i1, T v)
{
  Iterator i2(i1); // Copy Constructible
  typedef typename detail::iterator_traits<Iterator>::reference ref_t;
  ref_t r1 = *i1;
  ref_t r2 = *i2;
  T v1 = r1;
  T v2 = r2;
+ c));
    BOOST_TEST(*i == *(c + j));
    ++i;
    BOOST_TEST(i > j);
    BOOST_TEST(i >= j);
    BOOST_TEST(j <= i);
    BOOST_TEST(j < i);
  }

  Iterator k = j + N - 1;
  for (c = 0; c < N-1; ++c)
  {
    BOOST_TEST(i == k - c);
    BOOST_TEST(*i == vals[N - 1 - c]);
    typename detail::iterator_traits<Iterator>::value_type x = j[N - 1 - c];
    BOOST_TEST(*i == x);
    Iterator q = k - c;
    BOOST_TEST(*i == *q);
    BOOST_TEST(i > j);
    BOOST_TEST(i >= j);
    BOOST_TEST(j


1](#pone-0045313-g001){ref-type="fig"}). In these organisms FpoF/FqoF serves as the electron input subunit of a membrane-bound NADH-dehydrogenase type energy transduction system called F~420~H~2~ dehydrogenase complex [@pone.0045313-Johnson1], [@pone.0045313-Johnson2], [@pone.0045313-Deppenmeier1]. The C-terminal half of Fsr (Fsr-C; residues 325--620 of MJ_0870) is a homolog of Dsr [@pone.0045313-Johnson1], [@pone.0045313-Johnson2] ([Figs. 1](#pone-0045313-g001){ref-type="fig"} and [S1](#pone.0045313.s001){ref-type="supplementary-material"}). Fsr functions both as a dissimilatory (detoxification) and an assimilatory (sulfide nutrition) enzyme [@pone.0045313-Johnson1], [@pone.0045313-Johnson2] and Fsr-C does not show significant sequence similarity to aSir [@pone.0045313-Johnson1]. Two documented partial reactions of Fsr, namely dehydrogenation of F~420~H~2~ and reduction of sulfite [@pone.0045313-Johnson1] suggest that Fsr-N retrieves electrons from F~420~H~2~ and reduces FAD, and then via the Fe-S centers of Fsr-N and Fsr-C, the electrons from FADH~2~ are transferred to siroheme of Fsr-C where sulfite is reduced to sulfide; FAD acts as 2-electron/1-electronand Dsr-LP ([Fig. 2](#pone-0045313-g002){ref-type="fig"}); these scenario might change as these two genomes have not yet been fully sequenced. Within the Methanobacteria class, each of *Methanothermobacter* and *Methanothermus* species carried an Fsr homolog and lacked Dsr-LP homolog. *Methanobrevibacter* genomes were devoid of sulfite reductase homologs (Fsr or Dsr-LP) whereas *Methanosphaera stadtmanae* carried one Dsr-LP and was devoid of Fsr. The Dsr-LP was highly prevalent in the class of Methanomicrobia, each member carrying 1--4 homologs of this protein; Fsr was only rarely found in this group. The genomes of *Methanosarcina and Methanosphaerula* species encoded the maximum number Dsr-LP proteins (four homologs) and lacked Fsr. Methanogens that contained more than two Dsr-LP homologs are mostly mesophilic and psycrophilic. It seems that in these late evolving organisms Dsr-LP underwent recruitment to multiple


this simpler protein was considered as the recognizable earliest ancestor for all types of sulfite reductases. The anaerobic sulfite reductase (AsrC) which is expressed from the *asrABC* operon in *Salmonella typhimurium* and several *Clostridium* species was placed in a distinct clade. In our analysis we took a different approach. Since coupled \[Fe~4~-S~4~\]-siroheme center of sulfite reductases has not been altered significantly through about 3.5 billion years [@pone.0045313-Shen2], [@pone.0045313-Dhillon1], we considered full amino acid sequences of sulfite reductase proteins to obtain the clues to the evolutionary processes that have shaped the sulfite reductases of the methanogens and other organisms. In this analysis, alSir (DVU_1597 or Dv-alSir of *Desulfovibrio vulgaris*), AsrC (CPE1438 of *Clostridium perfringens*), Dsr-LP and Fsr-C were found to have Dsr type structural features ([Figs. 3](#pone-0045313-g003){ref-type="fig"} and [S1](#pone.0045313.s001){ref-type="supplementary-material"}).Abbreviations for organism names preceding the ORF numbers (in addition to those described in [Fig. 4](#pone-0045313-g004){ref-type="fig"} legend): Hbor, *Halogeometricum borinquense* DSM 11551*;* Huta, *Halorhabdus utahensis* DSM 12940; HacJB3, *Halalkalicoccus jeotgali* B3; Htur, *Haloterrigena turkmenica* DSM 5511*;* Rxyl_0964, *Rubrobacter xylanophilus* DSM 9941; Tter, *Thermobaculum terrenum* ATCC BAA-798; GZ27A8_52, uncultured archaeon related to *Methanosarcina* species; MmarC6, *Methanococcus maripaludis* C6; MmarC5, *Methanococcus maripaludis* C5; MmarC7, *Methanococcus maripaludis* C7; Mevan, *Methanococcus vannielii* SB; Mvol, *Methanococcus voltae* A3*;* AF, *Archaeoglobus fulgidus* DSM 4304, Msm, *Methanobrevibacter smithii* ATCC 35061*;* P06130, accession number for *Methanobacterium formicicum* FdhB. The bootstrap value shown at each branch is from 1000 replicates. Scale bar, number of amino acid substitutions per site.

(TIF)

######

Click here for additional data file.

######

Phylogenetic tree of Fsr-N homologs based on Bayesian Markov chain Monte Carlo


1. Field of the Invention
The invention relates to integrated circuit processing and, more particularly, to the introduction and patterning of interconnections on an integrated circuit.
2. Description of Related Art
Modern integrated circuits use conductive interconnections to connect the individual devices on a chip or to send and/or receive signals external to the chip. Popular types of interconnections include aluminum alloy interconnections (lines) and copper interconnections (lines) coupled to individual devices, including other interconnections (lines) by interconnections through vias.
A typical method of forming an interconnection, particularly a copper interconnection, is a damascene process. A typical damascene process involves forming a via and an overlying trench in a dielectric to an underlying circuit device, such as a transistor or an interconnection. The via and trench are then lined with a barrierQ:

h.264 encoding directly from numpy

I want to directly encode videos from numpy arrays of video frames. Open-cv offers such functionality via the cv2.VideoWriter, however I need the h.264 codec which is not available. The best I have so far is using open-cv to write the video and then reencode it via:
# write video from numpy arrays via cv2
out = cv2.VideoWriter("/tmp/video.mp4", cv2.VideoWriter_fourcc(*"mp4v"), fps, size)
for frame in frames:
    out.write(frame)
out.release()
# reencode video with ffmpeg
os.system("ffmpeg -y -i /tmp/video.mp4 -vcodec libx264 /tmp/video2.mp4")

However, I think that the first encoding is not loss less, so I am instead looking for a solution where I can directly encode videos from python.
Thanks for your help!

A:

scikit-video provides the feature:
import skvideo.io

outputfile = "/tmp/video.mp4"
writer = skvideo.io.FFmpegWriter(outputfile, outputdict={'-vcodec': 'libx264'})
for frame in frames:
    writer.writeFrame(frame)
writer.close()


by v.
3
Suppose -83 - 27 = -2*u. Suppose 2*b - 3 = u. Suppose -o = -4*o + 339. Calculate the remainder when o is divided by b.
26
Let p(g) = -g**3 + 33*g**2 + 93*g - 39. Calculate the remainder when p(35) is divided by 59.
58
Suppose 0 = 3*k - 25 + 7. Suppose 0 = -n + 8 + k. What is the remainder when 25 is divided by n*1 + 0/6?
11
Let u(q) = -q**3 + 30*q**2 - 2*q + 70. Calculate the remainder when u(30) is divided by 3.
1
Let x(i) = 5 - 2 + i + 0*i. Suppose f + 0*f = 49. What is the remainder when f is divided by x(10)?
10
Suppose 0 = r - 2*f - 1253, 11*r - 10*r - 1238built. Ticket sales would absolutely plummet, boycotts would start, etc.

5. David Stern very recently said that if the Kings wanted to move to Anaheim, they would not be allowed to. That's in one of the biggest media markets in the country, and one with an arena already built.

6. The likely costs of relocation would cost more than the city of Sacramento asked from the Maloofs to build a new arena in Sacramento, which they shot down.

7. About a billion different things need to happen before a team can move. The team must apply to relocate, the Board of Governors needs to approve, a new arena needs to be built, numerous contracts need to be signed. None of this has happened yet.

I could go on, but I don't think


if he were issuing
or coming into the field in base, and going out again in
chief.

Ivy. A plant that
runs up trees, walls, etc. "Ivy is the symbol of eternal
life." The arms of the Town of St. Ives. ar. an Ivy branch
overspreading the whole field vert.

The
Heraldry Dictionary by Armorial Gold Heraldry Services
is provided as a free resource tool for Heraldry
enthusiasts. The Heraldry Dictionary and the information
contained therein, has been researched through original
manuscripts and Armorial Gold’s own sources. Reproduction in any form is prohibited.
All rights reserved.[Vectorcardiography in infarction of the right ventricle].
A vectorcardiogram (VCG) was recorded in 22 patients in the acute phase of a right ventricular infarct in order to investigate any characteristic signs of this diagnosis. The RV infarct had been proven by at least two investigations: 2D echo, isotopes and right ventricular catheterisation. 17 patients had ST depression in V4R. The QRS complex presented two features: there was a reduced refractory period in every case, associated with septal extension in 3 cases and true posterior infarction in 11 cases, and, in the frontal plane, the QRS which was in clockwise rotation had showed an abnormal left axial lead in 18 cases with a maximal vectorial axis of between - 10 degrees and - 60 degrees. These modifications are similar to


to keep my eyes off of her milk swollen tits. The darkening areolas, nipples that had started to bead up with little droplets of milk as well as be perpetually hard turned me on so much that I ran to the bathroom right there in the mall and frigged myself.

But, if Shelly did realize the effect that she was having on me, she didn't let on. I was actually glad in a way. I didn't want to ruin our friendship by freaking her out but it also meant that I could still see her. It sounds selfish of me, I know, but I couldn't help myself. I pulled into her driveway, grabbed my bag and entered the home after knocking. I was pleasantly surprised at what I walkedairport and would be for another week. "The pressure's been killing me Britt. I was thinking of sucking the milk out myself just to get some relief." I nodded in sympathy. I'd never been pregnant before but understood what she was saying.

"Hey, maybe I can help." I said. A strange look crossed Shelly's face when she heard that. "Oh God, I mean that I could drive to the airport and get it." I quickly added. She laughed at that.

"Oh yeah. For a second, I thought that you were volunteering to suck the milk out." She and I laughed for a second or two before she looked at me, again with that expression on her face. "Would you?" I hopped up off the chair to go get my purse


the juices pouring out of her. She screamed again as another orgasm passed through her body.

Finally, she reached down and pushed my head away. I relented and raised up, looking at her face. Shelly's eyes were half lidded, a smile on her lips as her chest rose and fell with her labored breathing. I smiled at her, rose up and went to sit back down on the recliner. "God, it's been so long." she finally said. "Thank you."

"Um...my pleasure." I replied, not really knowing what to say to that. She laughed at my reply as she pulled the blanket back up, covering her belly but leaving her tits on display. "What do you mean 'it's been so long'?" I asked, a little curious by her words.

"It's been solong since I've cum." Shelly said. A look of consternation crossed her face. "Tom hasn't fucked me in months saying that he's afraid to hurt the babies. But I don't think that's it. I just don't think he likes to look at me anymore." Shelly started to cry at that and I hurried back over, taking her into my arms. I knew that this was hormones playing tricks with her but I didn't say anything, just letting her cry it out.

After a few minutes, Shelly let go of me and rolled back over so that she was laying on her back. "Come on Shell," I said, taking her hand. "You know he loves you and still wants you." She squeezed my hand for a brief second.

"I don't know


I get to tend the rabbits." " Yeah, you get to tend the rabbits." "When it rains in the winter, we'll just say "The hell with going to work,"" "and we'll just build a fire in the stove, and we'll just sit there and we'll listen to the rain." "Lennie, I want you to look around here." "If you get in any trouble, I want you to come right here." " You hide over here in the brush." " Hide in the brush." "You hide in the brush until I come for you." "Can you remember that?" "Sure I can, George." "Hide in the brush till you come for me." "If you do get in trouble, I ain't gonna let you tend the rabbits." "I'm not gonna get"A guy don't need no sense to be a nice fella." "Yeah." "He gets in trouble all the time cos he's so goddamn dumb." "Like what happened up north in Weed." "What'd he do in Weed?" "He seen this girl, in a red dress, and the dumb bastard that he is, he just..." "He wants to touch everything he likes, so he reaches out to touch this red dress." "So the girl starts screaming, and that gets Lennie all mixed up, so he holds on and he won't let go, cos that's the only thing he can think to do." "So what happened?" "Well, she runs off across the field, screaming." "So me and Lennie take off running." "Pretty soon we hear a bunch of guys with dogs


back." "All right, all right, all right." "Just sit down." "Calm down." "Go on." "Maybe you can see now." "You got George." "Suppose you ain't got nobody." "Suppose you can't go into the bunkhouse and play rummy because you's black." "Suppose you have to sit out here with the mules and read books." "Books ain't no good." "A guy goes nuts, he ain't got nobody." "I tell ya, a guy gets too lonely, he gets sick." "Maybe George come back already." "Maybe I better go see." "I..." "I didn't mean to scare you." "George gonna come back all right." "I was just talking about myself, that's all." "We're gonna get a little place of land and rabbits and windmill." "You're nuts." "(George) Lennie!" " That's George." "George isinto a cathouse..."" "Jesus Christ, Lennie." "You can't remember nothing that happens, but you remember every word I say." "I thought you was mad at me, George." "No." "I ain't mad." "I ain't never been mad." "You ain't gonna leave me, George." "I know you ain't." "Nope." "George, I done..." "I done a bad thing." "It don't make no difference." "George..." "George, where are we gonna go now?" "I don't know." "I..." "I like it here." "George, tell me like you done before." "About them other guys and about us." "(dogs barking in distance)" "George, tell it like you done before." "OK." "OK." "You look over there." "OK?" "I'll tell ya." "So you can almost see it." "OK?" " Where?" " Over there." " OK?" "Over there." "


with people more experienced or smarter than
you and they will support you.

So like I said, nothing wrong with tech debt, it's a byproduct in our industry
that we just have to accept and deal with.

------
vaibhavthevedi
I can tell you only a couple of things. See, It can get overwhelming very
quickly and it expands in deep as much as deep you go in technology.

You should rather focus on what you NEED to learn, don't get caught in
imposter syndrome. Because you mentioned you have a full-time job already, You
only have a limited time. Juggling and switching into lot of things will
affect your productivity.

For me, I evaluate first what I want to do and then search the technology
available around it. Then, I make a list of what I need to learn and Iof knowledge. I think this is a fascinating question regarding the
pursuit of software engineering. But to hold yourself to the standard of
having this in order for career advancement, I think there are easier ways.

Maybe that, or I am simply naive.

As my distributed systems teacher used to say: don't be scared by new terms of
concepts in computer science. When you think fundamentally about what things
are, you will realize that, most of the time, it's a concept that is similar
to something you have learned before, if not entirely the same.

~~~
rumanator
> To me it seems ridiculous that employers can require such an amount of
> breadth and depth of knowledge.

To be quite honest, those are generally nice-to-haves instead of must-haves.

Yet, if within a pool of 20 candidates there are 2 or 3


perfectly. Just
start with the thing that looks the most interesting / accessible to you. go
down the rabbit hole. Come back up, go down another. When you start getting
bored, start producing some stuff. there will always be opportunity costs no
matter what you chose to do. Just try to enjoy what you are doing. Another
trick is to copy someone you respect. Try to learn what they know. And when
you know more than them, find someone else to copy. One day people will start
emulating you.

------
growlist
I've found it helps to watch 'state of x in 2020' type videos to get a broad
overview, and weekly email newsletters can help stay on top of a particular
area.

Apart from that the skill is in knowing what you need to know about something.
For example I don't needI try to apply the very basic things i've
learned and iterate myself further by asking basic questions about stuff I
don't understand etc. After having reached a certain familiarity with
vocabulary and basics I try to explain why does tool X exist, what problem
does it solve, what pros and cons exist. I think about how I would explain the
necessity of X to someone who is not in the field. After that in the second
phase I learn mostly like everybody else from books, online resources and just
doing what I learn. But now I can read books a lot faster and with much fewer
frustration because my brain is familiar with it, knows why X exists and which
cool projects X is applied to. Thinking about it, my strategy is mostly
tricking my brain into


to accomplish work in the new technology.

Immediate- learning as part of my day to day job. This is learning I get from
having to figure out tasks (deeply reading the docs of our current tech stack
to figure an obscure error), to evaluate a technology or technique against our
current needs, or to learn a new technology that is part part of the job /a
new project or team I've joined. Most of this is one the job learning or
learning from others on my team, but sometimes there are relevant trainings.
There is no real time metric here- it just happens.

As for your concern about being up to date on every single technology that
might be listed on a job description, don't be. Most job descriptions are
"aspirational." Few hiring managers expect to be ableEssentially, we circumvent the arisen difficulties by a suitable use of the energy method and of fine integral estimates controlling interactions at the level of micro-surfaces.'
author:
- 'Vo Anh Khoa[^1], and Adrian Muntean[^2]'
bibliography:
- 'mybib.bib'
title: 'Correctors justification for a Smoluchowski–Soret–Dufour model posed in perforated domains'
---

Introduction
============

Diffusion and heat conduction, taken separately, are well understood processes at a large variety of space scales. However, as soon as diffusion interplays with the conduction of heat, it appears that the structure of the model equations is not so clear as one would expect, especially if one wants to describe settings away from the somewhat better understood thermodynamic equilibrium, where statistical mechanics is the main investigation tool.

Driven by possible applications in the context of efficient drug-delivery and in the design of intelligent packaging materials, we


Recruiting fathers for parenting research using online advertising campaigns: Evidence from an Australian study.
Fathers are underrepresented in parenting and child health research. Given there is a strong link between fathers' parenting behaviour and children's well-being, there is a need to find ways to engage fathers more consistently. The current short report provides information and learnings about recruiting fathers online using social media. Results are drawn from an Australian study that aimed to recruit roughly equal numbers of mothers and fathers to participate in a survey about employment, parenting, and health, using online advertising. First, a series of five Facebook advertising campaigns were run, aimed at "parents" generally (i.e., gender-neutral). A lack of recruited fathers prompted a second series of six Facebook campaigns aimed solely at fathers. All campaignsitself is a pretty hefty bill.

The Texas Senate wants to put $1.8 billion toward those efforts, and the Texas House wants to invest more than $4 billion — although it wants to ask voters for permission to spend most of that. Lawmakers will have to settle those differences before the session ends in late May. Whatever they settle on, the sum is sure to be a small sliver of the tens of billions of Harvey-related dollars Texas will receive from the federal government when it’s all said and done. But state lawmakers argue it’s still a major step. […] While both the Texas House and Senate leaders support the creation of a statewide flood plan and a revolving fund to help communities pay for projects, they disagree on


United Nations sanctioned Libya in response to the 1988 bombing of Pan Am Flight 103. Additional sanctions applied by the US Sanctions Act of 1996 were relaxed in 1999. Since then, American and other foreign oil companies have returned to resume their operations in Libya, led by AGIP (Italy), OMV(Austria), Veba (Germany), Total (France), Nimir (Saudi Arabia), WOC (National Oil Corporation, Conoco, Marathon, Amerada Hess), and ETAP of Tunisia.

Petroleum occurrence
In 2007, the Energy Information Administration estimated that the Sirte Basin Province contains approximately 80% of Libya's total proven oil reserves ( as of January 2007) and accounted for roughly 90% of the country's total oil output, which was  in 2006. Over twenty-three large oil fields and sixteen giant oil fields occur in the province. Libya's onshoreA page to help newcomers to the area and visitors to find out how to get around

Trains from Bruton Great Western Railway trains go to Westbury, Bath and Bristol or, in the other direction, to Castle Cary, Yeovil, Dorchester and Weymouth, and of course intermediate stations(about every two hours on weekdays and Saturdays, but fewer on Sundays). By changing at Westbury you can get to London Paddington (see below). South Western Railway trains go via Westbury to Salisbury and LondonWaterloo.

Trains to London and the WestcountryOur main line station isCastle Cary, 15 minutes by car from Bruton. For train times for London Paddington (or Taunton, Exeter and Plymouth)clickhere. (Less conveniently, you can go to London direct from Bruton by changing at Westbury, sometimes with rather a long wait; the


the hot-press process ([@R32]), which effectively improves the interlayer interaction compared to CNFP-0 and CNFP-1. For CNFP-3, the oxidation process introduces an amount of carboxyl groups on the surface of CNF. Those carboxyl groups of CNFs are further cross-linked by the calcium ions and polyacrylic acid. The calcium ions and carboxyl groups form strong ionic bond and further improve the interaction between layers. The nuclear magnetic resonance (NMR)--^13^C and Fourier transform infrared spectroscopy (FTIR) results verify the mechanism above, while the x-ray diffraction (XRD) result shows that the crystallinity of CNFs has no visible change after pretreatment (figs. S10, S11, and S12) ([@R33], [@R34]). By tuning the interaction between layers, it can be seen that when the interaction is enhanced, the interlaminar shear strength and flexural strength increaseenergy adsorption under high-velocity impact ([Fig. 5F](#F5){ref-type="fig"}). SHPB is a powerful tool to study the behavior of material under high--strain rate deformation. Its structure is shown in [Fig. 5G](#F5){ref-type="fig"}, and the strain gauge on the incident bar and the transmission bar can convert mechanical wave into electronic signal and yield the stress-strain curve. The highest compression stress of CNFP can reach \~1600 MPa during high--strain rate compression (14,000 s^−1^), and the energy absorption of compression is \~387.5, \~89.3, and \~37.0 MJ m^−3^ under the strain rates of 14,000, 10,000, and 7500 s^−1^, respectively ([Fig. 5H](#F5){ref-type="fig"}). The stress-strain curves in the SHPB experiments illustrate anomalous decline after the first peak compared with the common plastic platform area of traditional metal materials and energy absorbing materials. Under initial low strain


continue to develop policies and safeguards around the development and use of our machine learning technologies.”

While observers outside of Google and the Pentagon seem to be concerned about the nexus of tech and the American military-industrial complex, Gizmodo reported that a few anonymous employees within Google also had qualms about the collaboration first revealed in an “internal mailing list.”

That said, it won’t be the first time Google came under scrutiny for offering services to a federal agency. A 2017 report in Quartz shed light on the origins of Google and how a significant amount of funding for the company came from the CIA and NSA for mass surveillance purposes. Time and again, Google's funding raises questions. In 2013, a Guardian report highlighted Google's acquisition of the robotics companyhypertension (50%), no apparent cardiac disease (41%), coronary atherosclerotic heart disease (4%), mitral valve prolapse and other organic heart disease (5%). Negativation or accentuation of negative terminal forces of P wave were present in 84% of the patients, alterations in the QRS complex in 75% of the cases, and in the T wave in 66% of the cases, with confidence intervals of 0.7898 to 0.8901; 0.6907 to 0.8092; and 0.6163 to 0.7437, respectively. Important changes in the ECG record may occur with high probability if the chest electrode for lead V1 is placed above the standard place.


<!DOCTYPE html>

 <meta charset="iso-8859-15"> <title>UTF-8 BOM vs meta charset</title>
<link rel='author' title='Richard Ishida' href='mailto:ishida@w3.org'>
<link rel='help' href='http://www.w3.org/TR/html5/syntax.html#the-input-byte-stream'>
<link rel="stylesheet" type="text/css" href="./generatedtests.css">

<meta name='flags' content='http'>
<meta name="assert" content="A page with a UTF-8 BOM will be recognized as UTF-8 even if the meta charset attribute declares a different encoding.">

<link rel="stylesheet" type="text/css" href="the-input-byte-stream/support/encodingtests-utf8.css">

UTF-8 BOM vs meta charset

A page with a UTF-8 BOM will be recognized as UTF-8 even if the meta charset attribute declares a different encoding.

The page contains an encoding declaration in a meta charset attribute that attempts to set the character encoding to ISO 8859-15, but the file starts with a UTF-8 signature.

The test contains a div with aone thing, complete obscured faces and burkas are another. An Errol Flynn shirt and a tri-cornered hat are one thing, a sword and live parrot are another. But whether or not the FSM and Pastafarianism are both purely invented or not, Killians school may have opened a can of worms it might wish it hadn’t.

Easter weekend, April 6-8, 2007, is the time. Your blog is the place. The Separation of Church and State is the topic. Thanks to beepbeepitsme, I found this planned blog swarm, which I’ll participate in. I’m not sure what my meager contributions will be yet, but I hope the overall project is a huge success.

The idea is simple. Just post something related to, and in support of, the separation of church and state each


I checked out of the discussion, was the threat to his culture’s language as the language of immigrants replaces or infuses his own. Language is no doubt an integral part of culture. If you accept the Sapir-Whorf Hypothesis, as many linguists do, then you understand that language influences habitual thought through a kind of linguistic determinism (language determines the way we think). The extent to which language affects culture is debatable, but it’s clear that as languages both infuse and diffuse with cultures, changes in culture occur.

In my own community in the Dallas-Fort Worth area of Texas, the influence of the Mexican culture is prominent and the affect of the Spanish language obvious. Most businesses and government offices have literature in both Spanish and English, and many businessesabout 194 languages remain out of the hundreds that once existed. 73 of these are spoken only by adults over 50 and 49 spoken only by a scant few individuals. These figures are, at best, from the 1990’s, so they’re certainly much lower baring some sudden, massive revival where young people took the time to learn the languages of their elders. I heard it said once that Oklahoma was home to more dialects and languages than all of Europe. I don’t know if this is true or not, but the Native American population in the state is high. Interestingly enough, it’s also where a state-level Senator is pushing a bill to make English the official language. In her words:

The purpose of this bill is to establish a policy


1. Field of the Invention
The present invention generally relates to the field of mechanical soil processing means of rotary implements and more particularly, it is concerned with an agricultural maching adapted to perform mechanical processing of the soil under conditions of very high productivity and flexibility insofar as different displacements and working requirements are concerned.
2. The Prior Art
Generally, such machines, commonly called "agricultural hoes" or just "cultivators" are combined, for operation, with agricultural tractors having a weight and power suitable to the dimensions of the machines and from which the machines receive the power necessary for their advancement as well as for rotation of the implements.
An important and substantial improvement in the machines of the prior art and in the agricultural field in general has been made byJohn Legend?” asked MSNBC’s Craig Melvin.

“Hold on, it’s getting better,” said Spicer. “Melania Trump said, ‘The strength of your dreams and your willingness to work for them.’ Twilight Sparkle from ‘My Little Pony’ said, ‘This is your dream, anything you can do in your dreams.”

“So the RNC isn’t taking this seriously?” Melvin interjected.

“A simple Google search of three phrases comes up with everything from Sparkle Pony to John Legend to Akon,” Spicer said.

Unlike the phrases Trump lifted from Obama, none of Spicer’s examples are word-for-word matches.

Watch the clip above.

Spicer also quoted Twilight Sparkle on CNN to make the same point:

Here is the RNC'a chief strategist citing My Little Pony to argue that Melania Trump did not plagiarize her speech pic.twitter.com/eRifu41wHC — Dave Itzkoff (@ditzkoff) July 19, 2016

Legend tweeted


live in the Founder’s Edition available Wednesday, as well as the return of an eight-on-eight Team Vanquish mode. Turf Takeover supports up to 24 players (the game’s maximum) but is meant to be a shorter-playing match with kooky objectives. Later on, Battle for Neighborville will introduce a Battle Arena, where teams of four duke it out in a first-to-four-wins format.

PvE activities will take place in Neighborville’s Town Center and outskirts like the Weirding Woods and Mount Steep, which has some sort of backstory involving cheese mining. Garden Ops, the PvE horde-mode staple of the first two games, will also return.

The Founder’s Edition that launched Wednesday is a six-week preview, in lieu of a beta, that will roll out content and weekly events. Davidson said it will also givefrom organically derived essential oils. As such, the pain relief composition provides consumers with a technique to reduce the level of pain while not using artificial, man-made compositions. The organically-derived nature of the composition of the present invention has substantial value to those individuals who desire to reduce pain without using artificial, man-made compositions.
The pain relief composition is substantially a mixture of essential oils. Essential oils used in preparing the pain relief composition of the present invention include aloe vera, peppermint, lemon, orange, and rosemary oils. The concentration of aloe vera oil is between about 10 and 18 percent by weight and preferably between about 13 and 16 percent by weight. The concentration of eucalyptus oil is between about 0.5 and 5 percent by weight and preferably between


against several criteria. These include their state of maturity, their cross-border dimension, and the extent of positive externalities relating to technological innovation, security of supply or solidarity between countries. Projects submitted in response to this call will be evaluated in the coming months, and the results will be communicated in August 2018. A further call will also be launched in June 2018.str = "Hello, playground"
str.removeRange(Range<String.Index>(start: str.startIndex, end:advance(str.startIndex, 7)))
// "playground"

A:

In light of DarkDust's answer, we can make a very Swift-like extension that will make removeRange easier to use:
extension String {
    mutating func deleteCharactersInRange(range: NSRange) {
        let startIndex = self.startIndex.advancedBy(range.location)
        let length = range.length
        self.removeRange(startIndex ..< startIndex.advancedBy(length))
    }
}

Now you can use it as such:
let range = NSMakeRange(0,4)
var day = "Tuesday"
day.deleteCharactersInRange(range) // day = "day"

A:

Update for Swift 3
In Swift 3 it is required to use the range operators a..<b or a...b.
var aString = "This is just the beginning"
str.removeRange(Range<String.Index>(str.startIndex ..< str.startIndex.advancedBy(10)))

or even more concise
aString.removeRange(aString.startIndex..<aString.startIndex.advancedBy(10))


*/

class HTMLPurifier_Lexer_DOMLex extends HTMLPurifier_Lexer
{

    /**
     * @type HTMLPurifier_TokenFactory
     */
    private $factory;

    public function __construct()
    {
        // setup the factory
        parent::__construct();
        $this->factory = new HTMLPurifier_TokenFactory();
    }

    /**
     * @param string $html
     * @param HTMLPurifier_Config $config
     * @param HTMLPurifier_Context $context
     * @return HTMLPurifier_Token[]
     */
    public function tokenizeHTML($html, $config, $context)
    {
       $html = $this->normalize($html, $config, $context);

        // attempt to armor stray angled brackets that cannot possibly
        // form tags and thus are probably being used as emoticons
        if ($config->get('Core.AggressivelyFixLt')) {
            $char = '[^a-z!\/]';
            $comment = "/<!--(.*?)(-->|\z)/is";
            $html = preg_replace_callback($comment, array($this, 'callbackArmorCommentEntities'), $html);
            do {
                $old = $html;


then tokenize the rest of body.  We can't tokenize
        // the sibling directly as we'll lose the tags in that case.
        if ($div->nextSibling) {
            $body->removeChild($div);
            $this->tokenizeDOM($body, $tokens, $config);
        }
        return $tokens;
    }

    /**
     * Iterative function that tokenizes a node, putting it into an accumulator.
     * To iterate is human, to recurse divine - L. Peter Deutsch
     * @param{
      case Return(a) => run(f(a))
      case Suspend(r) => run(f(r()))
      case FlatMap(y, g) => run(y flatMap (a => g(a) flatMap f))
    }
  }
}

object IO2aTests {
  import IO2a._

  /*
  Pg 240: REPL session has a typo, should be:

  val g = List.fill(100000)(f).foldLeft(f) {
    (a, b) => x => Suspend(() => ()).flatMap { _ => a(x).flatMap(b)}
  }

  Note: we could write a little helper function to make this nicer:

  def suspend[A](a: => IO[A]) = Suspend(() => ()).flatMap { _ => a }

  val g = List.fill(100000)(f).foldLeft(f) {
    (a, b) => x => suspend { a(x).flatMap(b) }
  }


   Suspend(PrintLine(line))
  }

  /*
  How do we actually _run_ a `ConsoleIO` program? We don't have a `Monad[Console]`
  for calling `run`, and we can't use `runTrampoline` either since we have `Console`,
  not `Function0`. We need a way to translate from `Console` to `Function0`
  (if we want to evaluate it sequentially) or a `Par`.

  We introduce the following type to do this translation:
  */

  /* Translate between any `F[A]` to `G[A]`. */
  trait Translate[F[_], G[_]] { def apply[A](f: F[A]): G[A] }

  type ~>[F[_], G[_]] = Translate[F,G] // gives us infix syntax `F ~> G` for `Translate[F,G]`

  implicit val function0Monad = new Monad[Function0] {
    def unit[A](a: => A) = () => a
  Back to Business A Level to crack the Retail Industry.

The retail industry has never had it so tough, squeezed by a stagnant economy and the structural challenges thrown up by the rise of ecommerce.

However, every challenge also represents an opportunity, we were all taught that in A level business weren’t we?

1. Inspire consumers by curating the physical environment

All brands will have need for curators in the future to help communicate the joy of shopping. Tim Greenhalgh, chief creative officer at Fitch Worldwide, argues the new differentiators for brands will be innovations that play to consumers “dreaming and exploring mind states”.

Lego bringing the products inside its boxes to life using augmented reality technology that a three-year-old child can use is an ideal example of the how brands can inspire


is to create a very clear value proposition that gives the brand a point of difference.

3. Don’t be complacent about the competition

The explosion of ecommerce means “your biggest competitor may not even be known to you today but they will be known to you tomorrow”, according to Futures Company EMEA deputy managing director Henry Tucker.

Retailers that will succeed are those that understand how the consumer is changing and how to turn the changing behaviour to their advantage. However, the difficulty is judging the pace of change. In the words of Bill Gates: “We overestimate the change that will occur in the next two years and underestimate the change that will happen in the next 10″.

4. Data is your friend, avoid letting it swamp you

Retailers need to be greata bad thing.

First, it finds little
support for the much-discussed hypothesis of the Association of American Publishers and
Google's competitors that the mass digitization of major U.S. libraries will reduce the revenues
and profits of the most-affected publishers. In fact, the revenues of the publishers who believe
themselves to be most aggrieved by GBS, as measured by their willingness to file suit against
Google for copyright infringement, increased at a faster rate after the project began, as compared
to before its commencement. Their profits also increased significantly more on average from
2005 to 2008 than from 2001 to 2004. The increased rate of growth by publishers most affected
by GBS does not disappear when one compares it to the growth of the U.S. economy or to the
growth of retail sales. The continued rise in sales is


we're all catching our breath, let me just say that if there's a Catholic left in Europe -- or, hell . . . anywhere -- after all this, it won't be for the Catholic hierarchy's lack of trying. The devil is somewhere, but I doubt it's at the Times.

That said, we now return to our regularly scheduled outrage:

Father Cantalamessa’s comments about the Jews came toward the end of a long talk about scripture, the nature of violence and the sacrifice of Jesus. He also spoke about violence against women, but gave only a slight mention of the children and adolescents who have been molested by priests. “I am not speaking here of violence against children, of which unfortunately also elements of the clergy are stained; of that thereare used in the low range, while two forward ratios are repeated in the high range. This results in a standard 5 speed shift pattern. Another example of a combined range and splitter type compound transmission is the "Ecosplit" model of transmission sold by Zahnradfabrik Friedrichshafen Aktiengeseushaft of Friedrichshafen, Germany, which utilizes a separate splitter auxiliary section in front of, and a separate range auxiliary section behind, the main transmission section. Still another example is the RM0-13-145A thirteen speed transmission sold by Rockwell Corporation, in which the high range forward ratios are split.
Splitter shift systems may be either synchronized on non-synchronized. Conventional synchronizing systems, including those on compound transmissions having head end mounted splitters, use high force actuators which typically develop 500-600 pounds of force to effect the


splitter shift. Furthermore, these synchronized systems generally also require that the master clutch be disengaged on all splits, and employ costly master clutch interlocks in the case of head end mounted splitters. While nonsynchronized splitter clutching systems on either front or rear end splitters use lower force actuators, the resulting splitter shifts are often neither smooth nor jerkless.analyses also clarified the regulation mechanism of imprinted genes orchestrated by DNA methylation and histone methylation marks. Additionally, genetic analyses using Arabidopsis revealed new regulatory factors of DNA demethylation and imprinting and shed light on the more precise mechanisms.


however showing controversial effects \[[@ref10]-[@ref17]\]. *Arnica montana* is a plant belonging to the Compositae family and it grows in East and Central Europe \[[@ref18]\]. In particular, its anti-inflammatory action is linked to the lactone helenalin that seems to be involved in the inhibition of the pro-inflammatory transcription factor nuclear factor kappa B (NF-κβ) \[[@ref19]-[@ref27]\]. *A. montana* has been recently evaluated in several surgical settings such as esthetic and orthopedic surgeries, but currently, no single study is available in literature on the effects of this homeopathic remedy in breast cancer surgery. In the present study, a homeopathic preparation of *A. montana* 1000 Korsakovian dilution (1000 K) was administered preoperatively and postoperatively in a placebo-controlled, double-blind clinical trial to patients undergoing unilateral total mastectomy, with or without reconstruction, to evaluatecarried out. In the days following the surgery (days 2-4), the patients continued the previously assigned treatment. Vital signs, any concomitant medication, adverse event, and the presence of bruises or hematomas were monitored. Finally, patients were asked to provide an opinion on the perception of pain after surgery, using a visual analog scale (VAS). Day 5 concluded the study. On this day, the treatment previously assigned was continued, and the liquid collected by drains (if still positioned) was measured. If it was still not possible to remove the drainage, the amount of fluid drained was registered for the last time and, based on other parameters, the date of the possible discharge of the patient was indicatively anticipated. Conversely, if all parameters resulted in the normal range and drains


study.

Study Treatment {#sec2-4}
---------------

*A. montana* 1000 K was in the form of drops in 30% hydro alcoholic solution, with sublingual absorption. The 1000 K dilution is a very high homeopathic dilution produced according to the French Pharmacopoeia, starting from a mother tincture (complete plant extract) which undergoes 1000 steps of successive dilution and shaking in a 30% water--alcohol solution. The mother tincture of the product used in this study contained a minimum content of 0.04% of sesquiterpenes (expressed as dihydrohelenanin tiglate). According to the Korsakovian dilution method, the same flask was used for the entire preparation: At each step, the flask was emptied of most of the liquid but not dried, and then immediately filled again with the solvent. Because the residual volume after emptying the flask certainly cannotbelow 10 mL (b) per treatment (intention-to-treat and per-protocol datasets)](JIE-6-1-g006){#F2}

The presence of bruising and hematomas or breast swelling did not differ significantly by treatment group, *P* = 0.67 and *P* = 0.57, respectively. Even the perception of pain, measured by VAS, showed no statistically significant differences between the two treatment groups (*P* \> 0.05). All the recorded adverse events were not severe (e.g., rush, headache, nausea), not correlated with the *A. montana* treatment, and completely recovered at the end of the study. Moreover, they were equally distributed between the two groups: Five patients experienced at least an adverse event in the *A. montana* group versus four in the placebo group.

DISCUSSION {#sec1-4}
==========

In this study, which to our knowledge is the first to test the effect of *A. montana* in


Malaysian court rejects HINDRAF leaders application for release

Kuala Lumpur, Sept.17 (ANI): Hindu Rights Action Force (HINDRAF) legal adviser P. Uthayakumars bid to get a court order for his release on the grounds of medical neglect and endangerment of his life, has failed. High Court judge Justice Suraya Othman on Wednesday dismissed his habeas corpus application for his release. Last week, the Ipoh High Court rejected the habeas corpus applications of the five HINDRAF leaders - Uthayakumar, M. Manoharan, V. Ganabatirau, K. Vasantha Kumar and R. Kenghadaran - seeking their release from detention. Last month, Malaysias Attorney-General Abdul Gani Patail and Inspector-General of Police Musa Hassan said that Uthayakumar does not have the right to claim RM 100 million for defamation. Uthayakumar had filed for a RM 100 millionAC enzymes with a full catalytic activity and up to 1000-fold reduced affinity for CaM \[[@B49-toxins-09-00300],[@B50-toxins-09-00300]\]. It was further confirmed that all four regions of the AC domain contribute to CaM binding and that the CaM-induced conformational change of CyaA is crucial for catalytic activation \[[@B49-toxins-09-00300],[@B50-toxins-09-00300],[@B54-toxins-09-00300]\]. Biochemical and molecular modeling studies revealed that the β-hairpin (residues 259 to 273) of the AC domain interacts with the N-terminal domain of CaM (N-CaM) \[[@B55-toxins-09-00300]\]. Site-specific mutations in the β-hairpin resulted in conformational perturbations in metal binding sites I and II of N-CaM, while no significant structural modifications were observed in C-CaM \[[@B56-toxins-09-00300]\]. Intriguingly, when the AC domain interacts with intact CaM, the metal-binding sites I and II of CaM bind Mg^2+^ ions, while the sites III and IV of CaM


AC domain across target cell membrane \[[@B62-toxins-09-00300]\]. The AC-to-Hly-linking segment further appears to play a role in restricting the propensity of CyaA to form pores in target cell membranes. The CyaA variant lacking the N-terminal residues 6 to 489 exhibits, indeed, a strongly enhanced cell-permeabilizing and pore-forming activity \[[@B64-toxins-09-00300],[@B65-toxins-09-00300]\]. Furthermore, combined substitution of three negatively charged residues clustered within the N-terminal half of the linker segment of CyaA by neutral residues (D445N + D446N + E448Q) provoked a dramatic increase of the specific pore-forming capacity of the toxin without altering its specific capacity to translocate the AC domain across target cell membrane \[[@B62-toxins-09-00300]\]. Thus, the presence and clustering of negative charges in the AC-to-Hly-linking segment of CyaA appear to account for the relatively modest cell-permeabilizing capacity of CyaAof erythrocytes, thus accounting for the hemolytic halo that surrounds *Bordetella* colonies grown on blood agar plates \[[@B70-toxins-09-00300]\]. However, compared to typical RTX hemolysins, the specific hemolytic activity of CyaA is rather low \[[@B19-toxins-09-00300],[@B26-toxins-09-00300],[@B65-toxins-09-00300],[@B71-toxins-09-00300],[@B72-toxins-09-00300]\]. This suggests that the pore-forming domain of CyaA evolved towards a function in delivery of the invasive AC domain across target cell membrane, at the expense of its pore-forming capacity. However, the CyaA pore is too small in diameter to allow passage of even an unfolded AC domain polypeptide across the membrane. Moreover, mutant CyaA variants (e.g., E570Q + K860R) that are essentially unable to form pores and permeabilize cellular membrane for monovalent cations, are still fully capable to translocate the AC domain across the lipid bilayer of cell membrane \[[@B69-toxins-09-00300]\] by an as


co-expressed protein toxin acyltransferase CyaC \[[@B80-toxins-09-00300],[@B81-toxins-09-00300]\]. Initially, the native CyaA purified from *B. pertussis* (BP338) was found to be activated by amide-linked palmitoylation of only the ε-amino group of the lysine residue 983 \[[@B12-toxins-09-00300]\]. However, the recombinant CyaA produced in *E. coli* in the presence of CyaC was found to be acylated also on the lysine residue 860 \[[@B13-toxins-09-00300]\]. A double modification of both conserved lysine residues (K860 and K983) was then found also on CyaA secreted by the recombinant *B. pertussis* strain 18323/pHSP9, which produces increased CyaC and CyaA amounts due to expression of the *cyaCABDE* locus from a low copy number plasmid \[[@B82-toxins-09-00300]\]. It remains to be determined whether CyaA produced by clinical isolates is doubly acylated or mono-acylated.

Ablation of either of the acylation sites bysignal that is recognized by the T1SS apparatus formed by the CyaBDE proteins across the bacterial cell wall \[[@B16-toxins-09-00300],[@B92-toxins-09-00300]\]. Led by the C-terminal sequence, the toxin is extruded through the T1SS conduit in an unfolded state, directly from the calcium-depleted bacterial cytosol into the host body fluids containing millimolar concentrations of free calcium ions \[[@B9-toxins-09-00300],[@B15-toxins-09-00300],[@B93-toxins-09-00300],[@B94-toxins-09-00300]\]. At the low concentrations of calcium ions inside the bacterial cytosol, the RTX domain remains intrinsically disordered and highly hydrated \[[@B75-toxins-09-00300],[@B95-toxins-09-00300],[@B96-toxins-09-00300],[@B97-toxins-09-00300]\]. In the course of extrusion from bacterial cells, the binding of calcium ions from body fluids triggers folding of the emerging C-terminal segment \[[@B98-toxins-09-00300]\]. This forms a capping structure and scaffolds the calcium-driven co-secretional folding of the translocating RTX domain, which proceeds vectorially from the C-terminus towards the N-terminal end and ratchets


and accelerates toxin translocation out of the bacterial cell \[[@B15-toxins-09-00300]\].

3. Binding Interaction of CyaA with the Complement Receptor 3 on the Surface of Phagocytic Cells {#sec3-toxins-09-00300}
================================================================================================

Due to the extremely high specific enzymatic activity of the AC domain of CyaA, the toxin was found early on to bind and penetrate at low but well detectable levels a variety of eukaryotic cell types originating from diverse mammalian species \[[@B24-toxins-09-00300],[@B71-toxins-09-00300],[@B99-toxins-09-00300],[@B100-toxins-09-00300]\]. This non-saturable and unspecific cell binding is likely to be mediated by a low affinity interaction of the toxin with abundant cell surface glycoproteins, or glycosylated lipid molecules, such as certain gangliosides that accumulate in lipid microdomains of the plasma membrane of cells \[[@B20-toxins-09-00300],[@B101-toxins-09-00300]\]. Indeed, pre-incubation of the toxin with gangliosides, such as \>1 μM G~T1b~, strongly reduced the capacity ofonly the CD11a/CD18 molecule \[[@B17-toxins-09-00300]\]. Moreover, cell-binding and penetration of these cells is selectively blocked by certain CD11b-specific antibodies and dose-dependent saturable binding of CyaA is observed only with CHO cells transfected to express CD11b/CD18, but not with CHO cells expressing CD11a/CD18 or CD11c/CD18 integrins \[[@B17-toxins-09-00300],[@B18-toxins-09-00300]\]. At less than 1 nM CyaA concentrations, mimicking the physiological situation in vivo \[[@B111-toxins-09-00300]\], the binding of CyaA to CD11b/CD18 was shown to be a prerequisite for efficient toxin penetration into cells and high levels of intoxication of cells by cAMP, leading to CyaA-induced cell death \[[@B27-toxins-09-00300],[@B38-toxins-09-00300],[@B112-toxins-09-00300]\].

We showed that the initial interaction of CyaA with CD11b/CD18 depends on the recognition of N-linked oligosaccharide chains of the integrin receptor, where a significant reduction of CyaA binding is observed upon removal of the peripheral


across membrane into cell cytosol \[[@B58-toxins-09-00300]\]. AC translocation across the lipid bilayer is driven and controlled by the gradient of electrical potential across the membrane \[[@B59-toxins-09-00300],[@B125-toxins-09-00300]\] and exhibits a very short half-time of dozens of seconds \[[@B71-toxins-09-00300]\].

In parallel to translocation of the AC domain, the hydrophobic pore-forming domain of CyaA is critical for the second activity of the toxin in target membranes ([Figure 5](#toxins-09-00300-f005){ref-type="fig"}), namely for its ability to form oligomeric cation-selective transmembrane pores \[[@B9-toxins-09-00300],[@B11-toxins-09-00300],[@B66-toxins-09-00300],[@B68-toxins-09-00300],[@B69-toxins-09-00300],[@B126-toxins-09-00300]\]. While translocation of the AC domain into cell cytosol appears to be a linear function of toxin concentration, the pore-forming activity of CyaA is a higher order function of toxin concentration and exhibits a Hill cooperativity number higher than 3 \[[@B25-toxins-09-00300],[@B34-toxins-09-00300],[@B68-toxins-09-00300],[@B127-toxins-09-00300],[@B128-toxins-09-00300]\]. This suggests that monomers of CyaA can deliver the AC domain acrosscell nucleus, where it up-regulates transcription of the *Bim* gene, yielding a persistent increase of pro-apoptotic BimEL levels in cell cytosol \[[@B112-toxins-09-00300]\].

6.5. Intraepithelial Dendritic Cells {#sec6dot5-toxins-09-00300}
------------------------------------

IAE-DCs of myeloid origin are found in both the epithelium and submucosa of conducting airways, as well as on the alveolar surfaces \[[@B171-toxins-09-00300],[@B172-toxins-09-00300]\]. During the response to infection, these bona fide DCs are further replenished by monocyte-derived DCs (mo-DCs) \[[@B173-toxins-09-00300]\] and upon activation by TLR ligands, the IAE-DCs and mo-DCs mature and migrate to the lung-draining lymph nodes to trigger the T cell response.

To get a grasp of the complexity of the subversive CyaA/cAMP signaling in host DCs, we have performed a global and unbiased phosphoproteomic analysis of the early phases of cAMP intoxication of mouse BMDCs by CyaA \[[@B163-toxins-09-00300]\]. Among others, this


diacylglycerol, the cAMP/Epac signaling thus blocks the bottleneck step of the converging pathways of oxidative burst triggering \[[@B30-toxins-09-00300]\].

This helps to understand why CyaA plays an important role in the early stages of airway colonization by *B. pertussis*, at least in the mouse model of infection \[[@B187-toxins-09-00300],[@B188-toxins-09-00300],[@B189-toxins-09-00300],[@B190-toxins-09-00300],[@B191-toxins-09-00300]\]. Indeed, no CyaA-deficient clinical isolates of *B. pertussis* have been reported yet, by difference to the massive spread of *B. pertussis* strains defective in production of pertactin, or to occasional isolation of strains deficient in production of filamentous hemagglutinin or pertussis toxin. Further, the 5 kb-large *cyaA* gene exhibits a particularly high degree of sequence conservation across the global population of clinical *B. pertussis* strains \[[@B192-toxins-09-00300],[@B193-toxins-09-00300]\], indicating a high selective pressure for conservation of function of the toxin.

CyaA activity accounts for numerousthe main target cell on which CyaA needs to exert its biological activity and CyaA was, hence, not required for successful infection of neutropenic mice \[[@B104-toxins-09-00300]\]. However, upon infection of neutropenic mice with *B. pertussis* strains, Andreasen and Carbonetti observed a role for CyaA action on neutrophils only in the immune (convalescent or passively immunized by serum) mice but not in the naive mice \[[@B104-toxins-09-00300],[@B196-toxins-09-00300]\]. This indicates that neutrophils are not the only CR3-expressing target on which CyaA has to act in the mouse airway to support a successful infection of this non-natural host of *B. pertussis*. To which extent these results reflect the limitation of the mouse model in reproducing the protective immune mechanisms operating in human airways remains unknown. Nevertheless, these results are consistent with the


pulmonary disease caused by pertussis toxin in infants, but would also prevent bacterial infection and more-or-less asymptomatic colonization, which accounts for the current massive transmission rates of *B. pertussis* in highly aP-vaccinated populations of older children and adults. The detailed characterization of the structure--function relationships and mechanisms of action of key virulence factors, such as CyaA, offers the potential of their use as protective antigens in new vaccines. As reviewed here and summarized in [Figure 6](#toxins-09-00300-f006){ref-type="fig"}, CyaA activity interferes with a broad range of functions of phagocytes that are the sentinel cells of innate immunity. CyaA-caused paralysis of opsonophagocytic killing of the bacteria appears to play a key role in the early stages of colonization by *B. pertussis*. This makes CyaA toxoid to a leading antigen candidate forinclusion into the next generation of aP vaccines. Induction of CyaA-neutralizing antibodies by future aP vaccines is expected to enable neutrophils and macrophages in the airway of vaccinated subjects to fully deploy their bactericidal opsonophagocytic killing activities. Such maximizing of the protective potential of the opsonizing antibodies against bacterial surface antigens, comprised in the aP vaccine, is then expected to enhance also protection against *B. pertussis* infection and not only against the clinical disease.

This work was supported by grants GA15-09157S (R.O.) and 16-05919S (J.M.) from the Grant Agency of the Czech Republic, by project LM2015064 from Ministry of Education, Youth and Sports of the Czech Republic (R.O.), by project UNCE204025/2012 of the Charles University in Prague (A.O.), by grant 228216 from the Grant Agency of the Charles University


Image and text provided by Washington State Library; Olympia, WA

VOLUME XXXII.816 CELEBRATIONFOR ARMISTICE DAYHusine-s Houses to Close From: 10:30 Until 12:00 o'clock Tues—Soldiers Will Parade■ aPromptly upon the llth hour ofthe Hth day of the llth monthevery bell, whistle and other noisemaking device in Pullman will turnloose to full capacity in celebrationof the first anniversary of the signing of the armistice. To be more explicit, the din is scheduled for 11:00o'clock next Tuesday morning, andevery citizen is asked to unleash allthe noise he can command.The morning class periods at thecollege will be shortened In order'that all students may be dismissedat 10:45.Plans for the celebration of Armistice day were perfected yesterdayby the chamber of commerce commute in charge of the affair, including Gorge H. Gannon, P. C. Forrest,and Professoris;of vUal 'importance to the public, as|well as to the employers and wageearners.The Pullman HeraldDevoted to th« be.t int,re.t. of Pul| m , and the p. eate , farming community in the Norlhw , urroundi itHOLIDAY DECLARED !FOIt NOVEMBER 18Stores Will Close While W. S. C. andWashington U. Clash on Gridiron—Hundreds Coming forGame. iAll Pullman will declare a holiday'on the afternoon or* Saturday, No- \vember 15, the occasion of the first!invasion of Rogers field, the State'College's athletic stadium, by the;University of Washington footballteam in it; years. Business houseswill close from 2 o'clock until after jthe game to give the clerks i n opportunity to attend the' game. The matter wa3 discussed at the meeting of |the chamber of commerce Tuesdayand the suggestion of Athletic Di- 1rector J. F.


IIwas decided by the committee ofthe Washington Bankers' associationand the college authorities that amuch better program could be secured for their convention at thattime.WAWAWAI BOY BURIED HEREFuneral services for Cacti Lew isWillis, aged 17 years, three monthsand eight day*, who succumbed atWawawal Mommy from typhoidfever, were held Wednesday morning from Kimball's chapel, In chargeof the Rev. John ', Law of the Methodist ,11111'!. Interment was la theCity cemetery. 11,.- young man wasthe son of" Mr. and Mrs. Ralph Willis and enjoyed a wide friendship.NUMBER 3you listed are obvious,im more interested in things like:CurrentDataState.apk,DataCopy.apk,FileCopy.apk,FileCount.apk while they sound important the phone copies files.etc fine without them,also does anyone know where or how android stores the language files?

Oh,one thing i found out,opening CameraFirmware.apk with Anycut will let you update camera firmware.The process takes about 2 minutes,after that the app is useless.

Most services you listed are obvious,im more interested in things like:CurrentDataState.apk,DataCopy.apk,FileCopy.apk,FileCount.apk while they sound important the phone copies files.etc fine without them,also does anyone know where or how android stores the language files?

Oh,one thing i found out,opening CameraFirmware.apk with Anycut will let you update camera firmware.The process takes about 2 minutes,after that the app is useless.

Click to expand...

the camera firmware tip worked but when I opened the camera app it said it was the wrong


exclaimed “they have SURRENDER?!?”. From this point forward he SURRENDERED every 12, 13, 14, 15 and 16 versus a dealer 10 or Ace.
I played out the shoe and left. Could this have been a cover play for the guy that first shoe???decentralized, so we can’t rely on a third party to manage the transaction as with PayPal. Bitcoin approaches this by doing a lot of math.

For person A to transfer a coin to person B, person A signs the hash, or unique ID, of the last Bitcoin transaction to occur and the public key, of person B. This process defines a transaction.

Why don’t the transactions get mixed up?

…we propose begins with a timestamp server. A timestamp server works by taking a hash of a block of items to be timestamped and widely publishing the hash, such as in a newspaper or Usenet post [2–5]. The timestamp proves that the data must have existed at the time, obviously, in order to get into the hash. Each timestamp includes the previous


associated with individuals. But, this isn’t always the case. When you go to buy a pizza from the store with Bitcoin, someone is now able to associate the transaction public key with you. How do we prevent that? Many wallets generate new public-private key pairs after each transaction so it’s hard to associate a single public key on the blockchain with an individual.

What are some cool things about Bitcoin?

That’s it! If you have any questions, feel free to leave a comment or give me a shout on social media! Thanks for reading!

Twitter, Github, Snapchat, Instagramphenomenon, mass transfer of solute into the interior of the sorbent particle is reduced further.
Many of the negative effects on plate height caused by stagnant mobile phase loading in porous particles may be alleviated by decreasing particle size, and therefore pore length. However, as noted above, this strategy requires operation at increased pressure drops.
Recently, it was suggested by F. E. Regnier that chromatography particles having relatively large pores may enhance performance by allowing faster diffusion of large molecules. It was thought that increasing pore size might alleviate the pore entry clogging problem and permit diffusion into the particles relatively unhindered by pore effects.
There is a different class of chromatography systems which are dominated by convective processes. This type of system comprises sorbent surfaces distributed along flow channels that


For example, 2 .mu.m non-porous particle columns can separate a mixture of seven proteins in less than fifteen seconds. However, this approach cannot solve the engineering challenges presented by the requirements for purification of high molecular weight materials as dramatically demonstrated in the table set forth below.
______________________________________ CHARACTERISTICS OF NON-POROUS PARTICLE COLUMNS ______________________________________ Particle 10 5.0 2.0 1.0 0.5 0.1 0.05 Size (.mu.m) Surface 0.6 1.0 3.1 6.3 10 63 105 Area (m.sup.2 /ml) Pressure 17 68 425 1700 6800 17000 68000 Drop (psi/cm of bed height) ______________________________________
As illustrated by these data, small particles, whether present in packed columns or membranes, have very serious pressure problems at particle sizes sufficient to provide large surface areas and large loading capacity. In contrast, 300 .ANG. pore diameter particles in the#include"io.h"

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{
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Trump advances controversial oil pipelines with executive action

The decision to advance the pipelines cast aside efforts by President Barack Obama's administration to block construction of the two pipelines, while making good on one of Trump's campaign promises.

As he signed the documents Tuesday in the Oval Office, Trump also vowed to "renegotiate some of the terms" of the Keystone bill and said he would then seek to "get that pipeline built."

Trump also issued executive actions declaring oil pipelines constructed in the US should be built with US materials, streamlining the regulatory process for pipeline construction and shortening the environmental review process.

Trump during his campaign said he would streamline the approval of the Keystone XL pipeline, which was stalled for years in the Obama administration until Obama denied approval forand activists were also quick to slam the decision, with Tom Steyer, the president of NextGen Climate, accusing the Trump administration of putting "corporate interests ahead of American interests."

"The pipelines are all risk and no reward, allowing corporate polluters to transport oil through our country to be sold on the global market, while putting our air and water at serious risk," he said in a statement.

Meanwhile, Sen. Heidi Heitkamp, a Democrat from North Dakota where the Dakota Access Pipeline is being built, welcomed the move, as did Sen. Joe Manchin, a Democrat from West Virginia.

"What this country needs is more jobs, and that is why I have always been a proponent of the Keystone XL Pipeline and was an original cosponsor of legislation approving the Keystone XL Pipeline


evidence of criminal activity would be found in a second search. The affidavit does not explain why the AUSA held that belief; instead, it states only that the AUSA knew Defendant was part of an ongoing investigation by federal authorities.[7] Thus, Investigator Neal's affidavit seeks the issuance of a search warrant solely on the grounds that an AUSA believed a search would be fruitful.
Even considering all the surrounding circumstances and the deference to be given the magistrate's decision, see Upton, 466 U.S. at 733, 104 S.Ct. at 2088, Investigator Neal's affidavit did not supply a substantial basis on which the magistrate could find probable cause for issuing the second search warrant. As part of the totality of the circumstances, Magistrate Huguenin could have considered the fact and fruitsrecognized the insufficiency of the evidence. United States v. Taxacher, 902 F.2d 867, 871 (11th Cir.1990), cert. denied, ___ U.S. ___, 111 S.Ct. 1307, 113 L.Ed.2d 242 (1991).[12] Focusing on the officer, "... the test is whether the officer acted in objective good faith under all the circumstances." Id. Taxacher is valuable in directing the focus of the inquiry; however, the more difficult problem then presented is discerning exactly what a reasonable officer is expected to know. Unquestionably, officers are not legal technicians, so they are not expected to understand the intricacies of Fourth Amendment jurisprudence. *1584 On the other extreme, today's officers are professionals who certainly are expected to recognize the insufficiency of a "bare bones" affidavit that offers only an officer's unsupported and unexplained opinions.
Divining the


middle ground between these two extremes requires recognition of two competing points: (1) that aligning too closely with the first could lead to avoidable, gross infringements of citizen's Fourth Amendment rights; and (2) that aligning too closely with the latter could, in practice, destroy or unduly limit the "good faith" exception the United States Supreme Court saw fit to create in Leon. Since Leon, many critics have pointed to its "good faith" exception as evidence of the Court's weakening of the Fourth Amendment. Whatever the merits of such criticism, the lower courts are obligated to apply Leon. When doing so, however, jealous protection of citizens' Fourth Amendment rights remains a fundamental obligation of the courts.
Following from the Court's obligation to guard jealously citizens' Fourth Amendment rights is theY>
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        friend constexpr auto operator&&(X&& x, Y&& y);


been mentioned at the end of chapter 6, after he discusses the mizvah of the eating of the mazzah.

It must be that according to the Rambam the eating of maror in these times is not a mizvah onto itself in terms of eating maror but rather mederabanan it’s a part of sipur Yezi’at Mizrayim, similar to the arba kosot of wine which is a fulfillment as well of sipur Yezi’at Mizrayim.

(Rabbi Genack then brings a proof to this suggestion).

The Rosh (Arvei Pesahim Chapter 25) writes that maror needs a ka-zayit because we say in the nusach of the bracha “al achilat maror” and an eating cannot be less than a ka-zayit. The Shagat Aryeh (Chapter 100) asks on this Rosh that the reason maror mi-de-oraita, should need ain these days reclining is not necessary and therefore even if one didn’t recline by mazzah he would be yotze. Therefore if one did recline by Korekh, mazzah as a reshut would be mevatel the maror.

This answer, however, is not sufficient because if we look at the opinion of the Mechaber who doesn’t take the Ravya’s opinion into consideration, the question resurfaces. The Mechaber says that if one didn’t recline for the second or third cup he must drink again and recline and the Mechaber is not concerned about adding onto the arba kosot. Therefore, in our said case if one didn’t recline during the eating of mazzah, let him do it by Korekh and be yotze his maror and mazzah (both according to the opinions of Hillel


the crying, he immediately started asking people to borrow a ladder for the apartment was above ground level. After a long search he finally retuned with a ladder and climbed to the window where the crying was coming from. It turned out the parents of these children went out for a walk and the kids were alone, awake and crying. From the window Rav Avraham spoke to the children and calmed them down and remained until the parents returned. Later Rav Avraham would deny the story until a picture surfaced. He said one of the lessons from this story is that one should never think they are alone. G-d is always watching and is always there to give comfort.

The Magen Avraham (Siman 271 Seif Aleph) says that weinterventions are implemented among the 2006 baseline population of Beijing, China, based on which the model has been practiced and validated [@pone.0085676-Zhou1]. All 16 priority PAHs recommended by USEPA are included in the study.

Materials and Methods {#s2}
=====================

Study Population and Baseline Scenarios {#s2a}
---------------------------------------

A total of 15.81 million residents lived in our study area in the year 2006, consisting of 84% urban and 16% rural residents; other major characteristics of this population were: 51.1% male, 31.1% smokers, 72% employed and 9% school-age children [@pone.0085676-BeijingMunicipalBureauof1]. More detailed information can be found in our previous paper [@pone.0085676-Zhou1].

The overall Beijing population was divided into "Urban" and "Rural" sub-populations, because of the difference in major risk factors (*e*.*g*. use of solid fuels indoors). The "Baseline" scenarios were then defined for these two sub-populations respectively,


the lifetime e B\[a\]Peq xposure concentration.

While PAF was used to estimate the risk attributable to PAH exposure in a given scenario, another parameter, potential impact fraction (PIF), was introduced to evaluate the effectiveness of a certain intervention strategy. It is the proportional reduction if associated risk factor were reduced to a non-minimal counterfactual exposure [@pone.0085676-Ezzati1], and it can be calculated using the following equationwhere is the average relative risk in the MC simulation of the intervention case.

Intervention Cases {#s2c}
------------------

We analyzed and compared the effectiveness of the intervention strategies listed in [Table 1](#pone-0085676-t001){ref-type="table"}. These cases were designed to address the risks faced by either the urban or the rural sub-populations. The effect of the intervention was quantified comparing with the baseline scenario for each sub-population (urban or rural). Thesome other PAH congeners could also bring percentage change of over 1% but were omitted for clarity, which included BaP, Nap, DBA, BbF, BkF, Acy in all seasons, and IP, Ant, BaA, Phe, Flu in winter. They all had smaller percentage influence than BaP in winter.

*^b^*Quantity of coal used could also bring percentage change of over 1% but was omitted for clarity. It had smaller percentage influence than the quantity of wood and crop residues used.

*^c^*SD stands for standard deviation, which is listed in brackets.

*^d^*Values separated by "/" are percentage changes when subtracting or adding standard deviations to the baseline values.

*^e^*Rankings of variables for urban and rural sub-populations respectively are listed in brackets; the table is sorted by the larger of the percentage changes in annual inhalation dose


for urban and rural sub-populations.

The top five parameters have great influence on the final rankings of the intervention strategies for rural households, while only outdoor PAH concentration (represented by BaP; notes of [Table 3](#pone-0085676-t003){ref-type="table"} include a full list of the contributing PAH congeners) has significant influence on this ranking for urban households. The sixth and seventh factors (penetration coefficient and smoking quantity of all family members) are already shown to have negligible effect on the general ranking, and thus smaller factors are not included in this analysis. This effect can be observed by the overlapping of the ranges corresponding to a ±SD change in a specific parameter for the cases that are adjacent in ranking. The overlapping of these ranges would suggest a change in ranking if takingthe risk estimates can change dramatically when the alternative URR (1.30) is used. However, in any of the cases, the ranking of the interventions in terms of either PAF or PIF does not change. Nonetheless, this fact draws the attention to the important role that URR plays in determining risk estimate. The value 4.49 that we used was from a study on a rural population in Xuanwei, China, who were exposed to coal smoke from cooking [@pone.0085676-He1] and the value of 4.49 has been adopted to analyze the lung cancer risk due to inhalation exposure to PAHs in Chinese population [@pone.0085676-Zhang1]. It is therefore considered suitable for the application in the population in this study. However, it can never be too cautious when choosing a value for URR.

10.1371/journal.pone.0085676.t004

######


concentration can represent an entire residence. This assumption is justified by the fact that people generally move around in their homes/offices. If the proportion of time spent at different rooms within the house is of interest, models accounting for spatial heterogeneity should be used instead. Further, it is assumed that airborne PAHs follow the linear instantaneous equilibrium assumption, and that indoor emissions are evenly distributed over a 24 hour period. These two assumptions do not significantly bias the calculation of total airborne concentrations, and are therefore suitable for assessing inhalation exposure [@pone.0085676-Zhou1]. However, the proposed model in this study cannot be used to calculate phase-specific PAH concentrations and thus cannot be used to estimate dermal or ingestion exposure [@pone.0085676-Shi1], and it is why we only studied the inhalationVehbi Dibra

Haxhi Vehbi Agolli mostly known as Vehbi Dibra (12 March 1867 – 24 March 1937) was an Albanian mufti, theologist, politician  and a delegate of Dibër in the Albanian Declaration of Independence.
 He was also the first chairman of the Albanian senate and the first Grand Mufti of Albania's Sunni community from 1920 to 1929. Vehbi Dibra will also be remembered as the main organizer of the Congress of Dibra.

Life
Vehbi Agolli was born in the city of Debar on 12 March 1867 to Ahmed Effendi Agolli, mufti of Upper Debre. He studied Islamic theology, law and philosophy and was appointed mufti of Dibër. In 1909, he was elected chairman of the Congress of Dibër, a precursor assembly of the Albanian Revolt of 1910. In November


of the whole band would be observed for much larger control pulses when ${\epsilon}_S(t)$ straddles ${\epsilon}_p(t)$, such that ${\epsilon}_p(t)$ is switched on after and switched off before the control pulse.

Control of photodissociation yields.
--------------------------------------

![(a) Photodissociation spectra in the presence of the control pulse using the intuitive sequence for different control peak amplitudes and (b) the resulting branching ratio $\chi = P_{2}/P_{1}$. In (a) we give the total yield of dissociation ($P_{1}+P_{2}$). The peak amplitude of the control field for the different results is the following: In dashed line $\epsilon_{S}=0$; in black line with squares $\epsilon_{S}=−0.01$; in red line with circles $\epsilon_{S}=0.02$; in blue line with solid triangles $\epsilon_{S}=0.03$ and in blue line with empty triangles $\epsilon_{S} =−0.03e/a^{2}_{0}$. All other parameters in the simulations are given in the text. (Adaptedfrom J. Chem. Phys. 130, 124320, Fig.7.)[]{data-label="icl2"}](fig9){width="0.80\columnwidth"}

In Fig.\[icl1\] we showed the photodissociation spectra, with the expected band shifts. However, as indicated in Sec.2, when a strong pulse couples two states, the nature of the states change by virtue of the polarizability. In particular, there will be some probability that a nuclear wave packet dissociating at the band corresponding to $V_1$ will actually be in the excited $V_2$ state and viceverse. For an approximately constant $\Omega_S = \mu_{12}(R) {\epsilon}_S(t)$ the probabilities are roughly given by $$\chi = \frac{P_2}{P_1} \sim \left( \frac{\Omega}{2\Delta} \right)^2.
\label{ratio}$$ where $\Delta$ is the energy gap between the electronic states. The first question, then, is why in Fig.\[icl1\] we observe only one product, the electronic channel corresponding first to $V_1$ and then to $V_2$, at the two


**2015**; Vol. 162, pp. 122-125.

I. R. Sola, V. S. Malinovsky, Phys. Rev. A **2003**, 68, 013412. B. Y. Chang, S. Shin, I. R. Sola, J. Phys. Chem. Lett. **2015**, 6, 1724. B. Y. Chang, S. Shin, I. R. Sola, J. Chem. Theor. Comput. **2015**, 11, 4005. B. Y. Chang, S. Shin, I. R. Sola, J. Phys. Chem. A **2015**, 119, 9091. J. S. Melinger, S. R. Gandhi, A. Hariharan, J. X. Tull, W. S. Warren, Phys. Rev. Lett. **1992**, 68, 2000. Y. B. Band, O. Magnes, Phys. Rev. A **1994**, 50, 584. J. Cao, C. J. Bardeen, K. R. Wilson, Phys. Rev. Lett. **1998**, 80, 1406. V. S. Malinovsky, J. L. Krause, Eur. Phys. J. D **2001**, 14, 14. K. Bergmann, H. Theuer, B. W. Shore, Rev. Mod.first drivers' title for Team Penske since Sam Hornish, Jr. in 2006. In the manufacturers' championship, Chevrolet successfully defended their title ahead of Honda.

Teams and drivers
 All chassis were composed of a Dallara DW12 "IndyCar Safety Cell" base chassis, and Dallara aerokit. All teams competed with Firestone tires. On December 21, 2012, Firestone signed a five-year contract extension with IndyCar to be the official supplier for IndyCar through 2018. The original engine lease contracts that were signed by the teams prior to the 2012 season were up for renewal prior to the 2014 season, and several teams switched engine providers for the 2014 season. The list below reflects drivers who competed in the 2014 season.
 (R) denotes an IndyCar Series rookie.

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 Juan Pablo Montoya returned


= syscall.Errno(0x23)
	EALREADY        = syscall.Errno(0x25)
	EAUTH           = syscall.Errno(0x50)
	EBADF           = syscall.Errno(0x9)
	EBADMSG         = syscall.Errno(0x58)
	EBADRPC         = syscall.Errno(0x48)
	EBUSY           = syscall.Errno(0x10)
	ECANCELED       = syscall.Errno(0x57)
	ECHILD          = syscall.Errno(0xa)
	ECONNABORTED    = syscall.Errno(0x35)
	ECONNREFUSED    = syscall.Errno(0x3d)
	ECONNRESET      = syscall.Errno(0x36)
	EDEADLK         = syscall.Errno(0xb)
	EDESTADDRREQ    = syscall.Errno(0x27)
	EDOM          = syscall.Signal(0x8)
	SIGHUP    = syscall.Signal(0x1)
	SIGILL    = syscall.Signal(0x4)
	SIGINFO   = syscall.Signal(0x1d)
	SIGINT    = syscall.Signal(0x2)
	SIGIO     = syscall.Signal(0x17)
	SIGIOT    = syscall.Signal(0x6)
	SIGKILL   = syscall.Signal(0x9)
	SIGPIPE   = syscall.Signal(0xd)
	SIGPROF   = syscall.Signal(0x1b)
	SIGPWR    = syscall.Signal(0x20)
	SIGQUIT   = syscall.Signal(0x3)
	SIGSEGV   = syscall.Signal(0xb)
	SIGSTOP   = syscall.Signal(0x11)
	SIGSYS    = syscall.Signal(0xc)
	SIGTERM   = syscall.Signal(0xf)
	SIGTRAP   = syscall.Signal(0x5)
	SIGTSTP   = syscall.Signal(0x12)
	SIGTTIN   = syscall.Signal(0x15)
	SIGTTOU   = syscall.Signal(0x16)
	SIGURG    = syscall.Signal(0x10)
	SIGUSR1   = syscall.Signal(0x1e)
	SIGUSR2   = syscall.Signal(0x1f)
	SIGVTALRM = syscall.Signal(0x1a)
	SIGWINCH  = syscall.Signal(0x1c)
	SIGXCPU   = syscall.Signal(0x18)
	SIGXFSZ   = syscall.Signal(0x19)
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// Error table
var errorList = [...]struct {
	num  syscall.Errno
	name string
	desc string
}{
	{1, "EPERM", "operation not permitted"},
	{2, "ENOENT", "no