builder is designed to display words that take this into account.

Probability Of Letter Occurrence: Letters like Q, K, J, Z, and X will boost the strength of the word, while letters like R, S, T, L, N, and E will usually put a word at the bottom of the list.

# Of Letter Recurrence: If a letter appears more than once, you are giving the opponent more bang for their buck when they guess. For example, say you had the word TOOTER. If they guess T, they will get two blanks filled in. In addition, if they guess O, they will get another two blanks filled in. Higher strength words will have unique letters with little or no recurrence of letters.

The word guesser option will allow you to enterin (\[x1Example\]).  Recursive analysis in powers of $x$ immediately gives $c_{k}\left(  t\right)  =t^{k-1}$, where we have $\emph{defined}$ the form and scale of the $t~$parameterization by the *choice* $c_{2}\left(  t\right)  =t$, to be in agreement with (\[ExactExample\]).  For instance, with $x_{t}\left(  x\right)
=x+tx^{2}+c_{3}\left(  t\right)  x^{3}+O\left(  x^{4}\right)  $ we find$$\frac{x_{t}\left(  x\right)  }{1-x_{t}\left(  x\right)  }-x_{t}\left(
\frac{x}{1-x}\right)  =\left(  t^{2}-c_{3}\left(  t\right)  \right)
x^{4}+O\left(  x^{5}\right)  \ .$$ Thus (\[UnitStepFE\]) is satisfied if and only if $c_{3}\left(  t\right)
=t^{2}$.  So it goes to higher orders in $x$, with each $c_{k+1}$ determined by $c_{j\leq k}$ to satisfy (\[UnitStepFE\]) — not just by direct expansion of (\[ExactExample\]).

The result for the approximation is therefore$$x_{t}^{\text{(}N\text{ approx)}}\left(  x\right)  =\sum_{k=1}^{N}t^{k-1}\ x^{k}=\frac{\left(  1-t^{N}x^{N}\right)


Q:

SwiftUI Landmarks App Tutorial Screen Navigates Back When Toggle Favorite

I'm following this SwiftUI tutorial and downloaded the project files.
I built and ran the complete project without any modifications. In the app, if I:

Toggle "Show Favorites Only" on in the list view
Tap into the "Turtle Rock" or "Chilkoot Trail" detail view
In the detail view, I toggle the favorite button (a yellow star icon)

The screen will jump back to the list view by itself.
But if I tap into the detail view of the last item ("St. Mary Lake") in the list view, I can toggle the yellow star button on and off and still stay in the same detail view.
Can anyone explain this behavior? What do I need to do to stay in the detail view without being forced to<!DOCTYPE html>

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  <meta name="viewport" content="width=device-width, initial-scale=1">
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    Foreman v2
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create


Thursday, March 6, 2014

Presenter

The basic design of optical microscopes remains unchanged since Hooke and van Leeuwenhoek peered through them four centuries ago; today's light microscopes simply project an image of a slice through a sample onto either our eyes or a camera. However, by engineering a microscope's point spread function (PSF), or its impulse response to a point source, we can encode much more information into these images. In this talk, I highlight the double-helix (DH) microscope, an imaging system that bends the light emitted from point objects into a double-helix shape via a phase mask placed at a conventional microscope's pupil plane. I show that when utilized in concert with single-molecule photoswitching techniques like (F)PALM and STORM, the DH microscope routinely images 3D structures within living cellsthere is a very good chance you could start exceeding your daily limit.
Second, storage limits in your org.  As your number of customers increase the amount of data you're storing is going to increase quicker than your available storage.
Additionally, you have the additional risk that the customer may turn off Salesforce to Salesforce or mess up the configuration.
In terms of expectations for Salesforce to Salesforce, sharing basic records is very straightforward, but sharing complex relationships quickly starts to be a royal pain.  A worst case example is sharing opportunities with products which requires first sharing accounts, and products, then the opportunity, and finally the opportunity line items.
In summary, you'll want to crunch the numbers for expected record volumes and API calls based on your


Agerris's focus will be to equip farmers and growers with cutting-edge air and ground field robotic systems, intelligent tools and AI solutions.

Founded by University of Sydney Professor of Robotics and Intelligent Systems , and 2019 NSW Australian of the Year nominee Salah Sukkarieh , Agerris is an intelligent robotics company that has commercialised two robotics platforms designed to improve the productivity of livestock and horticultural farmers.

The start up’s focus will be to equip farmers and growers with cutting-edge air and ground field robotic systems, intelligent tools and artificial intelligence (AI) solutions, to improve farm productivity and to support animal welfare and environmental sustainability.

To support Agerris’s development of agricultural robotics systems, intelligent automated tools and artificial intelligence, the investment is one of the largest seed investment rounds raised fordoing so, cleans its surface to reveal her face underneath. In this symmetrical composition, which can be aggressively confrontational, she employs clay as a metaphorical tool for articulating transformation of internal and external selves. By exploring the notion of masking identity, Haleh focuses on alienation and transformation of one's self. Masking alludes to one of the iconic characteristics of identity perceived in a different cultural context as means of transforming, disguising or displaying identity.

Press
During her career, she was interviewed by the press including Reza Jalali for Shargh newspaper during her exhibition in Atbin gallery in 2005, Sara dehghan for Voice of America's Persian News Network (VOA) ( Shabahang program ) in 2010  and  Florence Somer Gavage for Kahkeshan TV during her exhibition as a part


here nor there, group show, Edinburgh-UK

2009
 Patriothhall Gallery, Pause, group show, Edinburgh-UK
 Collective Gallery, Stand by, group show, Edinburgh-UK

2007
 La Viande Gallery, Proof (?) of Identity, group show, London-UK
 2002-05 Iran
 Atbin Gallery, solo show, Tehran-Iran
 Daryabeygi gallery, solo show, Tehran-Iran
 Wall+House+Painting,
 Site specific work, group show, Tehran- Iran
Elaheh gallery, group show, Tehran-Iran

Awards
-6° International Arte Laguna Prize,Shortlisted, Nappe of Arsenale of Venice -Italy, 2012
-Arts Education in Practice Professional Development Award,SQA, Glasgow-UK, 2008

Commission
Mural of Trees of Life depicting trees from Middle East as part of Paradise Restored exhibition in   the Royal Botanic Garden Edinburgh, Edinburgh-UK, 2012

Artist residency
Inverleith house & Royal Botanic Garden Edinburgh, Edinburgh-UK, 2012

References

External links
Part one Interview between Haleh Jamali and Sara Dehghan with English subtitle
Part two Interview between Haleh Jamali and Sara Dehghanto "become compliant," and ultimately intended to "take out a personal loan to get caught up on his back taxes."

Navarre ruled his officer "exonerated"—meaning that the allegations, while true, were "lawful and reasonable"—of three policy and procedure violations the bureau had investigated.

HONESTY IS THE BEST POLICY

Risenhoover emerged from the investigation unscathed, at least initially, but Althoff and Olsen were not so lucky.

Investigators heard conflicting stories from underage and adult witnesses about whether the off-duty cops had drank alcohol with them or had played a version of beer pong that used water instead of beer.

One witness, 17-year-old Gage Moore, agreed to be interviewed by a City Weekly reporter in the presence of his father, Mark Moore. He recalls that Olsen and Althoff knocked and came in. "They were being


"As a result, there has not been, and there will not be, any final and conclusive adjudication of those findings," Navarre wrote.

Less than a month after Althoff and Olsen left the force, Chief Navarre cleaned out his own desk.

He'd announced his intention to resign in May, but his sudden departure came as a surprise to those in the department. No replacement has yet been found, though months before, Navarre stressed the need for an "exit plan" that would leave Moab "under the watchful eye of a competent new Chief of Police."

Interim City Manager Everitt wrote in an email in response to questions, that, "I understand the Chief elected to postpone his resignation for a few months, particularly given the active investigations and staff turnover happening at that time."shame that they – and by extension, supporters – are being let down by a lack of infrastructure which means that well-meaning initiatives such as Family Day are nowhere near as good – or as effective – as they could be.


Hide Transcript Show Transcript

WEBVTT WASINTOXICATED BEHIND THE WHEEL,AND THAT LED TO AN UNUSUALPARKING SPOT.AUTHORITIES SAY THIS IS THERESULT OF RONALD HOLLAR MIXINGALCOHOL, HIGH-SPEED, AND A DEADEND ROAD.UNFORTUNATELY THE END OF THATTRIFECTA WAS INSIDE THE SPECTRALLIBERATION SCULPTURE THAT SITSOUTSIDE THE GREATER DES MOINBOTANICAL GARDEN.>> IS DONE ABOUT $250,000 WORTHOF DAMAGE TO SOMETHING THE CITYIS VERY PROUD OF.MARCUS: THERE SEEMS TO BE LITTLEQUESTION AS TO WHAT HAPPENED.>> HE DROVE OFF THE END OF ADEAD-END STREET.MARCUS: HE DROVE -- HEACCELERATED AND THE ENGINE WENTTOO FAST.HIS EYES WERE BLOOD SHOT ANDWATERY AND HE ADMITTED TO, DRINKING.WHEN ASKED TO ESTIMATE HOWINTOXICATED HE WAS HOLLAR STATED, HE WAS A SIX.HOLLAR WAS GIVEN A BREATH TESTAND HAD BLOOD DRAWN ATMETHODIST.WORD QUICKLY SPREAD ABOUT WHATHAPPENED TO THE STATUE ANDTUESDAY MORNING PEOPLE HAD TOCOME SEE FOR THEMSELVESupon his screeds against the anonymity of modern, urban life while working within an American popular fiction idiom which privileges the description of externalities from which the reader is to infer interiorities. However, Crichton does describe several characters’ interior lives, albeit perfunctorily, and just as the novel reads like the treatment for a screenplay, these formulaic passages seem like notes for the actors who might step in and bring them to life. A more conventional adaptation would undoubtedly have sought to animate them through the verisimilar and melodramatic strategies typical of Hollywood productions (such as Crichton himself deployed, with some success, in adapting Robin Cook’s Coma (1977) in 1978), but Hodges takes a rather different path. He transforms Crichton’s dyspeptic, incoherent jeremiad into a rigorous critique of totalizing


cameras.)

The transformation of Hamilton into Wilson culminates in an effective double revelation. Although audiences might have been expecting Wilson’s new face to be that of Rock Hudson, who through the 1950s and 1960s epitomised a certain kind of hedonistic bachelor lifestyle (see Cohan 264-303), it is a Rock Hudson they had never seen before: white-haired, gaunt and scarred, enfeebled by surgical procedures. Frankenheimer uses the stiffness that sometimes infects Hudson’s performances to great advantage, upsetting the familiar ease with which one might expect him to occupy the spaces of Wilson’s stylish Malibu beach house. Instead, the uncertainty with which he moves through its rooms suggests not only the unfamiliarity of his physical and social location but also of his own body. It lends a vulnerable fragility to Hudson’sa company employee that he decides to visit his ‘widow’. (Wilson’s visit to Sue was shot but cut to reduce the film’s run-time, and the negative appears to have been lost.)

The film ends with Wilson, who has returned disillusioned to the company, finding himself gagged, strapped to a gurney and being wheeled into the Cadaver Procurement Section. Wildly distorted by a fisheye lens, he struggles against his bonds, but to no avail. A corpse with his build is required in the staging of a ‘fatal’ automobile accident.

Despite Frankenheimer’s close adherence to Ely’s narrative, he considerably transforms its meaning. The novel is an oddly moralistic, and unthinkingly misogynist, absurdist thriller about the dissatisfactions of the grey flannel suits who were produced in droves during post-war America’s period of corporate


crash, only to be guillotined. When Yvonne begs Gogol to save rather than amputate Stephen’s hand, he arranges with Rosset to obtain the corpse and secretly performs the transplant. This time it is Yvonne who has a troubling dream – a keyboard Stephen is playing becomes a railway track, along which a train rushes, its spinning wheel becoming Gogol’s face. The doctor himself retires to his study, where he plays an organ while watching Yvonne’s mannequin in a mirror, wishing it would come to life. He leafs through Elizabeth Barrett Browning’s Sonnets from the Portugese (1850), reading passages aloud.

Six months later, it is time to unbandage Orlac’s hands, which Gogol massages and probes in a shot which Reynold Humphrey’s suggests is more than merely an image of masturbationgood morning...

...hope you are having a great morning. So far mine is going great. I went to sleep early last night after hitting the gym. So I am energized! I am not going to fall off of the wagon this time. I hate it when I stop going to the gym. It makes you feel so good after working out. My goal is to lose 10 lbs by May 20th. There I said it out loud so now I am accountable. LOL Tonight I will go to Zumba which I love. The teacher is awesome and the dance moves are alot of fun. Here are some pics of Saadiq and Synai with their sleepy faces. LOL Saadiq is still sleep at 7:13am which is late for him. So


Q:

5 points for an upvote to an answer?

just a curiosity, how is it possible to receive 5 points for an upvote to an answer to this question

A:

There is daily reputation limit of 200 reputation points - meaning that it is not possible to get more than 200 reputation points in a single day from upvotes. (It is still possible to get more reputation points from accepted answers and bounties.)
In this specific case, you got to 195 reputation points (some upvotes on questions worth 5 points, some upvotes on answer worth 10 points) which meant the next upvote only added the amount missing to the daily cap of 200 points.

This is also explained in the help center:

You can earn a maximum of 200 reputation per day from the combination = syscall.Errno(0x1f)
	EMSGSIZE        = syscall.Errno(0x3b)
	EMULTIHOP       = syscall.Errno(0x7d)
	ENAMETOOLONG    = syscall.Errno(0x56)
	ENETDOWN        = syscall.Errno(0x45)
	ENETRESET       = syscall.Errno(0x47)
	ENETUNREACH     = syscall.Errno(0x46)
	ENFILE          = syscall.Errno(0x17)
	ENOATTR         = syscall.Errno(0x70)
	ENOBUFS         = syscall.Errno(0x4a)
	ENOCONNECT      = syscall.Errno(0x32)
	ENOCSI          = syscall.Errno(0x2b)
	ENODATA         = syscall.Errno(0x7a)
	ENODEV          = syscall.Errno(0x13)
	ENOENT          =


    = syscall.Errno(0x14)
	ENOTEMPTY       = syscall.Errno(0x11)
	ENOTREADY       = syscall.Errno(0x2e)
	ENOTRECOVERABLE = syscall.Errno(0x5e)
	ENOTRUST        = syscall.Errno(0x72)
	ENOTSOCK        = syscall.Errno(0x39)
	ENOTSUP         = syscall.Errno(0x7c)
	ENOTTY          = syscall.Errno(0x19)
	ENXIO           = syscall.Errno(0x6)
	EOPNOTSUPP      = syscall.Errno(0x40)
	EOVERFLOW       = syscall.Errno(0x7f)
	EOWNERDEAD      = syscall.Errno(0x5f)
	EPERM           = syscall.Errno(0x1)
	EPFNOSUPPORT    = syscall.Errno(0x41)
	EPIPE           = syscall.Errno(0x20)
	EPROCLIM  age (\<16 years or ≥16 years), and heterogeneity of the treatment effect was tested with a Cox regression model that included an interaction between treatment and subgroup.

The per-protocol analysis population consisted of all patients with blood-culture-confirmed enteric fever. We also analysed all patients who were assigned treatment, with the exception of those patients who were mistakenly randomised or withdrew before the first dose of study treatment, for treatment failure and safety.

All reported tests were done at the two-sided 5% significance level, and 95% CIs are reported. All analyses were done with the statistical software R version 2.9.1.[@bib21]

The trial is registered on [controlled-trials.com](http://controlled-trials.com), number ISRCTN 53258327.

Role of the funding source {#cesec70}
--------------------------

The sponsor of the study had no role in study design, data collection, data analysis, data interpretation, or writing


9 days (IQR 8--11) in the culture-negative population, but there was not a significant association between the duration of treatment and the time to relapse (HR=0·93, 95% CI 0·66--1·30, p=0·66).

There was no indication of treatment effect heterogeneity in the subgroups defined by pathogen or age ([table 4](#tbl4){ref-type="table"}).

Most adverse events were mild (grade 1 and 2; [table 5](#tbl5){ref-type="table"}). Adverse events were slightly more common in the culture-positive patients than the culture-negative patients. In the chloramphenicol group, 44 (25%) of 175 culture-positive patients experienced at least one adverse event (81 events in total). In the gatifloxacin group, 30 (16·9%) of 177 culture-positive patients experienced at least one adverse event (38 events in total). Three patients in the chloramphenicol group had a white-blood-cell count between 1500 and 1999×10^6^ cells per L Number of syndromic relapses           11                            7                                          ..
  Probability of relapse until day 62[†](#tbl3fn2){ref-type="table-fn"}     0·06 (95% CI 0·04 to 0·08)             0·03 (95% CI 0·01 to 0·05)    ..


onset. **b--d** Manhattan plot representing cancer GWAS SNPs tested in BRZ1 (discovery) cohort with p-value represented in −log~10~(*p*) for each SNP (n = 6059) (**b**). Manhattan plot representing the significant cancer GWAS SNPs (*p* \< 0.05) in BRZ1 and their validation in the BRZ2 cohort (*n* = 282, out of 303 significant in BRZ1) (**c**). Manhattan plot representing significant the cancer GWAS SNPs in both BRZ1 and BRZ2 and validated in the adult ACC cohort (*n* = 6, out of 7 significant in BRZ1 and BRZ2) (**d**). The significant SNP in the 3 cohorts is marked in red and pointed with an arrow.

Cancer GWAS SNPs and ACC age-of-onset in sporadic adult ACC {#Sec13}
-----------------------------------------------------------

The cohort of primarily adult ACC patients included 92 individuals (60 women and 32 men) diagnosed with a mean age of 47.16 years (range*U* test) Table [2](#Tab2){ref-type="table"} and Fig. [2d](#Fig2){ref-type="fig"}, in a manner similar to the paediatric cohort. In contrast to the paediatric cohort, patients heterozygous for rs971074 were diagnosed at older ages (16 years later than CC patients, *p* = 0.00038; 32 years later than TT patients, *p* = 0.00414, Mann--Whitney *U* test).Table 2rs971074 in the adult ACC cohort.CohortPatient numberMean (years)Median (years)Adult ACCGenotypeCC^a^6845.0145CT^b^1860.161TT^c^632.6729MAF0.163*p*-value (KW)0.00019adjusted *p*-value (Bonferroni)0.00114*p*-value (MWU) (CC vs TT)0.0498*p*-value (MWU) (CC vs CT)0.00038*p*-value (MWU) (TT vs CT)0.0041Adult ACC (somatic wild type p53)GenotypeCC5045.3446.5CT1660.1961TT53226MAF0.1831*p*-value (KW)0.00075*MAF* minor allele frequency, *KW* Kruskal--Wallis, *MWU* Mann--Whitney *U* test.^a^CC: Homozygous major.^b^CT: Heterozygous.^c^Homozygous minor.

Altogether, these data show that the rs971074 SNP associates with differential ACC age-of-onset in both *TP53* mutation carriers and non-carriers alike. However, in ACC patients with no inherited *TP53* mutations, the *TP53* gene is known to be somatically mutated (19.6%,


member of the RAR family that binds the retinoid ATRA to further activate down-stream RA signalling.^[@CR51]^

This is not the first time that lower expression levels of the RA pathway genes have been implicated in ACC.^[@CR52]^ In a meta-analysis of gene expression data from 164 adult adrenal tumours (97 adenomas and 67 carcinomas), significant reductions of three RA pathway transcripts were noted in malignant ACC relative to benign adrenal tumours. Specifically, *ALDH1A1, ALDH1A3, and RXRA* mRNAs were much lower in ACCs relative to adrenocortical adenoma.^[@CR52]^ The authors, therefore, hypothesised that RA production and signalling might be reduced in ACC and, therefore, its re-activation could be a therapeutic option,^[@CR52]^ as retinoids are already used in cancer treatment for acute promyelocytic leukaemia, and in cancer prevention for precancerous lesions in leukoplakia,actinic keratosis, and cervical dysplasia.^[@CR53]^ Support of this came from experiments in both cell culture and murine xenografts, whereby treatment of ACC with 9-*cis* RA resulted in decreased cell viability, proliferation, and steroid hormone production.^[@CR54],[@CR55]^ Our results offer human genetic evidence for the importance of this therapeutically relevant pathway in ACC onset and extends its relevance to progression of both paediatric and adult ACC. It is intriguing to note that a recent study of metastatic ACC tumours has identified an enrichment of driver mutations in RA pathway genes, possibly lending further support to the inactivation of this pathway being a crucial step in ACC progression.^[@CR56]^ In addition, alterations in the retinoic acid pathway have also been linked recently to benign adrenocortical tumours secreting aldosterone.^[@CR57]^

In conclusion, our results offer


Canadian cohort, approval was given by the Research Ethics Board of The Hospital for Sick Children (number 0019910602).

Consent for publication was approved by the Ethics Committee.

The websites used in the analysis for this study are publicly available websites: <http://www.cbioportal.org/>, <https://www.ebi.ac.uk/gwas>, <http://raggr.usc.edu> <http://hgdownload.soe.ucsc.edu/goldenPath/hg19/database/>, <https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=%20GPL6801>, <http://software.broadinstitute.org/gsea/msigdb>, <https://www.ncbi.nlm.nih.gov/gds>, <http://firebrowse.org/>. The data generated from the analysis during this study are included in this published article and its supplementary information files. Genotyping data for the Cancer Genome Atlas participants requires approval from the NIH.

The authors declare no competing interests.

This work was funded by the Ludwig Institute for Cancer Research, Conselho National de Desenvolvimento e Pesquisa (CNPq), Comissão de Pessoal de Ensino Superior (CAPES) and the CNRS *EXPOGEN-CANCER*. International Associated Laboratory (LIA).

How seeing the wealthy as ordinary people helped us provide them a basic need - intininit
https://medium.com/@affluentconfidante/how-seeing-the-wealthy-as-ordinary-people-allowed-me-to-provide-them-a-basic-need-29a551f18b69
======
PaulHoule
See
[https://immagic.com/eLibrary/ARCHIVES/GENERAL/IPCOM_US/I0209...](https://immagic.com/eLibrary/ARCHIVES/GENERAL/IPCOM_US/I020911I.pdf)
for the B2B version of this

------
blacksqr
Thank goodness the wealthy have someone looking out for them.

~~~
smt88
I agree. This amazing company is giving a voice to the voiceless rich, whom no
one ever listens to. Now we just need a company that will help them achieve
political power, since they are very underrepresented among elected officials
and campaign donations. /s

...but seriously, this company is a brilliant scam, like the $1M web page or
that iPhone app that cost $1,000 and did nothing.


coding for adipocyte plasma membrane-associated protein \[[@B21]\] was also shown to be highly expressed at late stages of adipogenesis of MEFs (cluster F).

Highly expressed genes over the differentiation course, especially at the middle stage of adipogenesis (after mitotic clonal expansion) could be found in cluster A. In this group we observed not only transcription factors like Klf9 \[[@B22]\], and Foxo3a \[[@B23]\] but also secreted factors (as studied in human \[[@B24]\]) including Apod \[[@B25]\], Ccdc80 \[[@B26]\], Adamts5 \[[@B27]\], Mmp2 \[[@B28]\], and Ptn \[[@B29]\], as well as enzymes, signaling molecules, and other factors such as Xdh \[[@B30]\], Enpp2 \[[@B31]\], Rgs2 \[[@B32]\], Txnip \[[@B33]\], Tsc22d3\[[@B34]\], H6pd \[[@B35]\], Igfbp2 \[[@B36]\], and Igfbp3 \[[@B37]\]. Hence, the genes in cluster A represent potential novel players in adipogenesis and are therefore candidates to be studiedFoxo1 and the key player in adipogenesis Pparg have expression profiles in cluster F. It has been previously shown that Foxo1 can interact with Pparg \[[@B40]\]. Furthermore, Foxo1 can bind to the Pparg promoter region and suppress Pparg expression \[[@B41]\]. Our analyses suggest that a feed-back loop from Pparg to Foxo1 might exist. To provide further evidence we analyzed two datasets of DNA binding by Pparg identified by chromatin immunoprecipitation (ChIP) followed by sequencing \[[@B42]\] or by microarray analysis \[[@B43]\] during 3T3-L1 adipocyte differentiation. Integrative analysis of these datasets and Pparg binding sites in genomic regions around genes with expression profile similar to that of Pparg in both the 3T3-L1 cells and MEFs (cluster F), revealed that Foxo1 might indeed be regulated by Pparg as indicated in Figure


approved the manuscript.

Supplementary Material
======================

###### Additional file 1

**Gene expression levels (log2-fold change) of 1579 in 6 cluster grouped ESTs at several time points during adipocyte differentiation of MEFs and 3T3-L1 cells (as visualized in Figure**[3](#F3){ref-type="fig"}**)**. ESTs were annotated according to the mouse RefSeq database (NCBI MegaBLAST E-value \< 1E-30) and Entrez Gene database. Unique genes within each cluster were identified and overrepresented gene ontology (GO) terms are provided.

######

Click here for file

###### Additional file 2

**Results and primer sequences from q-RT-PCR analysis for validation of microarray experiments and to identify expression levels for specific genes during ME3 and MEFA differentiation**.

######

Click here for file

###### Additional file 3

**Statistically overrepresented (*p*\< 0.05) potential transcription factor binding sites (TFBS) identified by *in silico*analysis of genomic regions from -3 kb to + 2 kbaround transcription start sites of genes with increasing gene expression at late stages of adipocyte differentiation (cluster F) using position frequency (weight) matrices from TRANSFAC and JASPAR**. Corresponding sequence logos from <http://genome.tugraz.at/Logo> are shown and number of targets within the dataset (cluster) is given and tested against the number of targets from all RefSeq transcripts using Fishers exact test. Note only transcription factor motifs are considered which are exclusively overrepresented in cluster F.

######

Click here for file

###### Additional file 4

**Gene expression levels (log2-fold change) of 3118 ESTs for samples from 3 different time points (d1, d3, d8) related to d0 immediately before hormonal induction of Rb-/- MEF (ME3) and Rb+/+ MEF (MEFA) differentiation.**Several distance measures between the expression profiles of the two cell differentiation models (sum of differences,


Manhattan distance, Euclidean distance, Pearson correlation coefficient) are provided. Unique genes upregulated (sum of differences \> 4) and downregulated (sum of differences \< -4) in the ME3 cell differentiation model compared to the MEFA differentiation are emphasized and overrepresented gene ontology (GO) terms are provided.

######

Click here for file

###### Additional file 5

**Gene set enrichment analysis of the gene list from comparison of Rb-/- MEFs and Rb+/+ MEFs during adipocyte differentiation ranked by sum of differences in a gene set of significantly upregulated (log2-fold change \> 2) genes in brown adipose tissue versus white adipose tissue**\[[@B46]\]**and in a gene set with significantly upregulated (log2-fold change \> 1) genes in brown versus white preadipocytes at the differentiating stages**\[[@B47]\].

######

Click here for file

Acknowledgements
================

This work was supported by the Austrian Ministry forand this inspired us create our shop Freyja’s Magic. In the spirit of Freyja, it is our mission to bring healing to others, and cultivate true beauty through our handmade body care, crafted in harmony with nature.

A Russian proverb states, “There was never a saint with red hair”, meaning all red-heads are prone to evil tempers and dissolute ways. In fact, one of the most famous Irish saints, Brigid, was a red-head.

It all began with Brid, the goddess of fire, patroness of hearth and home, smiths and forges, healers and herbs, poets and language. Honored in ancient Ireland, it was claimed that at birth, a column of fire reached from her red curls up into heaven. Many girls were named Brid, or Brigid, in her honor.

One such girl


On that day it is said Brigid travels through Ireland with her magic cow, blessing those who remember and honor their sacred roots.

Ancient Druids were aware of what they referred to as the Dragon coursing through their bodies and the universe. Practitioners of qigong know this as well called qi. The ancient Daoists revered the dragon too. Is it possible they were both talking about the same thing? Some Druids had red hair and there have been found redheaded mummies in China. Interesting…

“All vital life force – ‘chi’ – is interwoven with our hair.”

~Antonio Morocco, The Hair Shaman

We know instinctually that there is something magical about hair. It makes our face, reflects our health, and reveals our personality. Anthony Morocco, The Hair Shaman, has spent his life “fullydiminishing returns above two flanking bands). Two additional sets of diotic conditions were examined and compared to the condition where all eight comodulated flanking bands were present: In one set of conditions, two of the eight flanking bands were removed; in the other set of conditions, two of the eight flanking bands were replaced with bands (termed "deviant" bands) that were not comodulated with respect to the other bands. There was very little effect of reducing eight bands to six, even when the removed bands were relatively near the signal frequency; however, CMR was substantially reduced when deviant bands were introduced, particularly when the deviant bands were placed relatively near the signal frequency. These reductions in CMR were slightly greater when each of the deviant bands had a


unique modulation pattern (bideviant bands) than when the two deviant bands themselves shared the same modulation pattern (codeviant bands). In the second experiment, dichotic conditions were examined where the number and spectral positions of the flanking bands in the nonsignal ear were varied (the signal ear received only a 20-Hz-wide noise band centered on the signal frequency). The magnitude of the dichotic CMR ranged from approximately 2-10 dB, depending on condition. Effects of proximity and the number of flanking bands were similar to the effects obtained in diotic conditions. For both the diotic and the dichotic data, the effects of proximity were more consistent with an interpretation based upon across-channel processing than upon a within-channel interaction. The results obtained using deviant bands indicate that it is difficult forposted a summary of the report on his Twitter profile . Fundstrat's latest calculations coincide with his personal assessment , which he published in late April. In it Lee relies on a bitcoin trading price of $ 25,000 by the end of the year. He also assumes that the Bitcoin could be traded up to 2020 with up to 64,000 US dollars. He also argues with sinking mining costs as a price driver.

Overall, mining is considered an important factor for the Bitcoin price. Because the business with the computing power itself depends on electricity costs for the mining process. That's why more and more mining farms are moving north. This is where favorable mining conditions due to low temperatures, affordable hydro current and crypto-friendly laws lure . For


Hemifacial spasm due to contralateral aneurysmal compression of the facial nerve successfully treated with endovascular coil embolization: case report.
Hemifacial spasm is usually caused by compression of the facial nerve at the root exit zone (REZ), whereas fusiform aneurysmal compression is extremely rare. The authors describe symptomatic hemifacial spasm caused by a contralateral fusiform aneurysm of the vertebral artery (VA) that was treated by endovascular coil embolization. A 55-year-old woman developed left hemifacial spasm that had gradually worsened over a period of 2 years before admission to our hospital. Cerebral angiography showed an elongated right VA fusiform aneurysm near the VA union that inclined toward the left side. The cause of the facial spasm was considered to be compression of the left facial nerve REZ by the aneurysm. Endovascular    1  freebsd-ufs  (4.4G)
   9216000   1258317      2  freebsd-swap  (614M)

A:

This simply means that your /dev/da0 is not of the new "GPT" partition scheme, but of the old "MBR" partition scheme.
As from "man gpart", under the "PARTITION TYPES" section, you would see that there are no "zfs" related partition type for "MBR". Just use the "freebsd" type instead:
gpart add -s 10G -t freebsd da0

Then use the created "/dev/da0s2" device into your zfs.
By the way, why wanting to create a zfs from just 1 slice ? Would another ufs partition not being enough (my 2 cents) ?


and the swelling is under control,” Mahinmi said of his ankle. “Obviously, we’re working on my strength right now. I did a little bit in practice, but I’m not 100 percent yet. I’ll see how it feels tomorrow.”

Paul George�s minutes could be reduced to fight fatigue

The Pacers, rather loudly, hope they get their starting center back for Tuesday’s home game against the Los Angeles Clippers. Coach Frank Vogel was not sure that Mahinmi would be ready.

“There’s a 50 percent chance he plays tomorrow,” Vogel said. “He’s going to be reevaluated tomorrow.”

Without Mahinmi, whether because of injury or when he is on the bench, the Pacers’ defense has provided little resistance in January. The Pacers’ defensive rating, a statistic that measures points allowed per 100 possessions, is 100.2 thisa comparison of vaccine-delivered CD4+ T cell help (AFP, GPC3) with direct CD8+ activation only (MAGE-A3) on the frequency changes, functional quality and longevity of the corresponding CD8+ T cells. A.1 Specific Aim 1. Antigen Processing and Presentation. In this aim, we will analyze the intracellular processing of the loaded antigens in HBV+/HCV+ HCC patient DC in a preclinical, in vitro, setting. We will address several mechanistic questions about the differentially loaded DC vaccines: mechanism of protein uptake; intracellular antigen localization; duration of antigen presence and presentation; the effect of DC maturation; and the signal transduction pathways activated. A.2 Specific Aim 2. Lymphocyte activation. In this aim, we will analyze the result of presentation of the full length antigens (AFP, GPC3) and MHC class I-restricted peptide epitopes in


/* Author: Joshua Brindle <jbrindle@tresys.com>
 *         Jason Tang     <jtang@tresys.com>
 *         Ivan Gyurdiev  <ivg2@cornell.edu>
 *
 * Copyright (C) 2005 Tresys Technology, LLC
 * Copyright (C) 2005 Red Hat Inc.
 *
 *  This library is free software; you can redistribute it and/or
 *  modify it under the terms of the GNU Lesser General Public
 *  License as published by the Free Software Foundation; either
 *  version 2.1 of the License, or (at your option) any later version.
 *
 *  This library is distributed in the hope that it will be useful,
 *  but WITHOUT ANY WARRANTY; without even the implied warranty of
 *do not detect absorption coincident with the W ii line at 2088.02 Å, and we derive an upper limit from this line. We do, however, detect absorption coincident with the W ii line at 2118.88 Å. The upper limit derived from the former line is inconsistent with the absorption detected at the latter. The red line shown in the bottom panel of Figure \[specplot2\] is the 3$\sigma$ upper limit inferred from the line in the third panel of Figure \[specplot2\], not a fit to the line shown. We conclude that the absorption detected at 2118.88 Å  is not due to W ii, so we derive only an upper limit on the W abundance.

The Hg ii line at 1942.27 Å presents an interesting case. Absorption is clearly detected at this wavelength, but as shown in Figure \[specplot3\],


this blended, noisy line. The upper limit on Hg that we report in Table \[linetab\] is based on the entire absorption feature at 1942.27 Å resulting from an  isotopic mixture of Hg ii.

![ \[specplot3\] Comparison of observed and synthetic spectra for a selection of Os ii, Pt i, Hg ii, and Pb i lines. The squares mark the observed spectrum of . For Os ii, Pt i, and Pb i, the red line marks the best-fit abundance, and the gray shaded region represents a change in the best-fit abundance by a factor of $\approx$ two ($\pm$ 0.3 dex). for Hg ii, the red line represents the upper limit derived assuming Hg ii is responsible for all absorption at 1942.27 Å.  The bold black line represents a synthesis with no Os, Pt, Hg, or Pb present.metallicity. This material presumably originated in prior generations of CCSNe.

The AGB models discussed in Section \[agbnucleo\] also indicate that significant amounts of light elements (C to P, 6 $\leq Z \leq$ 15) are produced. The light and heavy elements produced by AGB stars should have the same dilution factor when material is transferred to or its natal cloud. The dilution factors derived in the fits to the heavy elements are so small ($<$ 2%) that any contributions from the AGB stars to N, O, Na, Mg, Al, Si, and P are negligible ($\delta$\[X/Fe\] $\leq$ 0.03 dex) when compared with the material produced in CCSNe.

The \[C/Fe\] ratio, $-$0.06 $\pm$ 0.19, tells a different story. This ratio is in agreement with the mean \[C/Fe\] ratio for main sequence and subgiant stars with \[Fe/H\] $> -$2, \[C/Fe\] $\approx -$0.12 (e.g., @gratton00 [@roederer14c]).


as $\log\epsilon$ and \[X/Fe\] in the top and middle panels, and the bottom panel illustrates the residuals between the observed abundance pattern and the sum of the models. ](f7b.pdf "fig:"){width="3.3in"}\
![ \[finalplot\] Comparison of the observed abundance pattern in and contributions from the  (blue),  (red), and  (gold) models. The  component is taken from the 1.7  TP-AGB model discussed in Section \[agbnucleo\]. The  component is based on the solar  residuals and modified as described in Section \[agbnucleo\]. The  component is based on the trajectory from @bertolli13 and tuned to maximize production in the As–Mo region as described in Section \[iprocess\]. The solid black line marks the sum of the three processes for each element. The overall normalization for each process has been adjusted by-eye. The distribution is expressed as $\log\epsilon$ and \[X/Fe\] in theCompute Canada, University of Victoria, the National Research Council of Canada, and the Canadian Space Agency. M.P. also acknowledges support from the “Lendület-2014” Programme of the Hungarian Academy of Sciences (Hungary), SNF (Switzerland), and the BRIDGCE UK network. This research has made use of NASA’s Astrophysics Data System Bibliographic Services; the arXiv pre-print server operated by Cornell University; the SIMBAD and VizieR databases hosted by the Strasbourg Astronomical Data Center; the Atomic Spectra Database hosted by the National Institute of Standards and Technology; the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute; IRAF software packages distributed by the National Optical Astronomy Observatories, which are operated by the Association of Universities for Research in Astronomy, Inc., under cooperative agreement with the National Science Foundation; and the R


    val img = drawable
        val w = width
        val h = height
        val imgW = getDrawableWidth(img)
        val imgH = getDrawableHeight(img)
        mBaseRect[0f, 0f, imgW.toFloat()] = imgH.toFloat()

        // 以图片中心点居中位移
        val tx = (w - imgW) / 2
        val ty = (h - imgH) / 2
        var sx = 1f
        var sy = 1f

   ScaleType.FIT_START -> initFitStart()
            ScaleType.FIT_END -> initFitEnd()
            ScaleType.FIT_XY -> initFitXY()
            else -> {
            }
        }
        isInit = true
        mFromInfo?.let {
            if (System.currentTimeMillis() - mInfoTime < MAX_ANIM_FROM_WAITE) {
                animaFrom(it)


 }

    override fun setAdjustViewBounds(adjustViewBounds: Boolean) {
        super.setAdjustViewBounds(adjustViewBounds)
        mAdjustViewBounds = adjustViewBounds
    }

    override fun onSizeChanged(w: Int, h: Int, oldw: Int, oldh: Int) {
        super.onSizeChanged(w, h, oldw, oldh)
        mWidgetRect[0f, 0f, w.toFloat()] = h.toFloat()
        mScreenCenter[w / 2.toFloat()] = h / 2.toFloat()
        if (!isKnowSize) {
            isKnowSize = true
            initBase()
        }
      return
        }
        val t: Float = if (r1.top > r2.top) r1.top else r2.top
        val b: Float = if (r1.bottom < r2.bottom) r1.bottom else r2.bottom
        if (t > b) {
            out[0f, 0f, 0f] = 0f
            return
        }
        out[l, t, r] = b
    }

    private fun checkRect() {


   val matrix: Matrix = imgView.imageMatrix
        val width = getDrawableWidth(drawable)
        val height = getDrawableHeight(drawable)
        val imgRect = RectF(0F, 0F, width.toFloat(), height.toFloat())
        matrix.mapRect(imgRect)
        val rect = RectF(
            p[0] + imgRect.left,
            p[1] + imgRect.top,
            p[0] + imgRect.right,
            p[1] + imgRect.bottom
        )
 depression, alcoholism, hip surgery, drug addiction, stroke, rheumatoid arthritis, heart attacks and bypass surgery.

Dr. Dossey, a medical internist, authored Healing Words and Prayer Is Good Medicine. In his book, he states, "I decided that not using prayer on behalf of my patients was the equivalent of withholding a needed medication or surgical procedure."

God, the Creator of your body, gives explicit instructions in your owner’s manual—the Holy Bible. This is just another proof that God is.

GOD SAID, I Thessalonians 5:18:

In every thing give thanks: for this is the will of God in Christ Jesus concerning you.

GOD SAID, Proverbs 17:22:

A merry heart doeth good like a medicine: but a broken spirit drieth the bones.

GOD SAID, Philipians 4:6-7:

6 Be careful for nothing; but in every thing by prayer and supplication with


fills only a part of the gap. Payments are capped, making them of less benefit to larger farms. Producers are reeling because of not just the size of the decline, but the speed. Futures contracts for Class III milk, a measure of wholesale prices, reached a high of $20 per hundred pounds in June on the Chicago Mercantile Exchange. By January, the price was below $10, though it has since ticked up to about $10.50. "This is an unprecedented time," Moore says. "In the 20 years I've been in this full time, I've never seen anything like it." Why prices are falling There are several reasons for the implosion: oversupply, falling export demand and continued high prices for supplies such as feed. The dairy sector in the pastexpression both in terms of form and content. He was a radical in both senses - new ways to write and new things to say, many of both controversial - for example - on the suffocating nature of Church hierarchy and priestly prerogative in his own Maronite communities in Lebanon and on the necessity of equality for women. He was subversive too of Ottoman claims, helping birth Arab nationalism, some of whose later history would have horrified him, a birthing that earned him a Turkish assassination attempt.

Second for his prescience for here was a writer alert to and sorrowing for the degradation of nature whether driven by greed or poverty. There is no social justice without environmental justice, no home for human being without human being making a


version of the `Pixy camera <https://pixycam.com/pixy-cmucam5/>`__, which comes
pre-configured to work as an IR beacon detector. There are multiple IR
beacons which are compatible with the sensor. The `MarkOne Beacon <https://irlock.com/collections/markone>`__
can be reliably detected in **all** **lighting conditions**, with a
detection range of **15 meters**. `Beacon (V1.1) <https://irlock.com/collections/shop/products/beacon>`__ is a more
cost-effective option which can be reliably detected in **most lighting
conditions**.

.. figure:: ../images/sensorandMarkers01.jpg
   :target: ../_images/sensorandMarkers01.jpg

   IR-LOCK Sensor and IR Beacons

Connecting to Pixhawk
=====================

The IR-LOCK sensor can be connected directly to Pixhawk via an `I2C cable <https://irlock.com/collections/shop/products/pixhawk-cable>`__. If
you are using multiple I2C sensors, then you will need an \ `I2C splitter <http://store.jdrones.com/Pixhawk_I2C_splitter_p/dstpx4i2c01.htm>`__.
More detailed instructions are included in the `irlock.com Documentation <https://irlock.readme.io/docs>`__.

.. figure:: ../images/precision_landing_connect_irlock_to_pixhawk.jpg
   :target: ../_images/precision_landing_connect_irlock_to_pixhawk.jpg

   IRLock sensor/Pixhawk Wiring

Mounting to the frame
=====================

The IRLOCK sensor should bewhen 2242 is divided by 203.
9
Calculate the remainder when 436 is divided by 145.
1
What is the remainder when 288 is divided by 45?
18
Calculate the remainder when 78 is divided by 77.
1
What is the remainder when 1841 is divided by 191?
122
What is the remainder when 581 is divided by 13?
9
What is the remainder when 246 is divided by 66?
48
What is the remainder when 2281 is divided by 751?
28
Calculate the remainder when 624 is divided by 28.
8
What is the remainder when 604 is divided by 55?
54
What is the remainder when 380 is divided by 56?
44
What is the remainder when 639 is divided by 133?
107
What is the remainder when 1207 is divided by 13?
11
Calculate the remainder when 13 is divided by 2.
1
Calculate the remainder when 1323 is divided by 96.
75
Calculate the


you are in ‘Funding’ scroll down to click on ‘Make an Application’.

What if I forget my password?

If you cannot remember your password click on the ‘Forgot Password’ link and follow the instructions onscreen. Forgetting the password is the most common reason for not being able to log in. Once you have entered your registered email address, a message appears onscreen to direct you back to that email address, where an automated email should be in your inbox. Click on the link within the message and reset your password when the page pops up onscreen. Please note that automated emails are sometimes directed to spam or junk folders.

Can I change my password whenever I want?

Passwords can easily be changed at any time by first accessing your account and thenby clicking into Edit My Details on the left sidebar. When changing your password this way it will activate on your next log in.

APPLICATION PROCESS – Creating an Application:

What type and size of files can I upload to my application?

All documents must be in PDF format no larger than 5MB in size. Some files with high resolution graphics (logos, signatures etc.) may be too large so you will need to reduce/compress these. Most PDF converters will automatically adjust the graphics and reduce their size appropriately.

How do I convert files to PDF format?

There are a number of built-in, free and paid-for PDF conversion tools available. Microsoft Office Word can save files in PDF format starting from version 2007. There are on-line PDF converters available for free or for a


received it.

How do I know if my application has been ‘accepted’?

After the deadline has passed the applications are checked to see if all parts have been submitted according to the relevant application category & guidelines. If it is accepted, the person named as the main correspondent on the application form will receive an acknowledgment with an application code, PIN reference and expected response time.

Is there any reason why an application may not be accepted?

Yes, there are some instances where this may occur:-

If any material submitted is incomplete.

If you attached (an) incorrect document(s).

If we are in receipt of an application requiring a pre-application meeting with the Production & Development Dept. and the applicant has not done this – this is a requirement for the production & distribution categories.

The abovefrom bad to worse. It was soon discovered that Sony's patch created its own security risk - potentially leaving personal computers even more vulnerable than with the initial rootkit - and was pulled from its website.

Sony BMG has released the full list of XCP CDs

The recall was even bigger than anticipated as Sony disclosed that there were at least 52 affected CDs. Moreover, researchers estimated that the damaging program had infected at least 500,000 computers in 165 countries.

Finally, just when it appeared that Sony had hit bottom, analysis of the rootkit revealed that it included open source software code contrary to the applicable licence.

In other words, Sony itself may have infringed the copyright of a group of software programmers and be on the hook for significant copyright infringement


selected, he must have solved a problem associated with the block. This selection process is called "proof-of-work" as it implies the miner had to work for it. To fully understand the mechanism involved, we need to first understand a cryptographic concept known as a _hash function_. Then, we can explain how it is used in the context of a miner's proof of work.

### Cryptographic hash function—a digital "fingerprint"

_Cryptographic hash_ is a complex algorithm that performs a very basic task–transforming text of arbitrary length (an entire book, a document, a sentence, or even a single word) into a fixed-length string of numbers that appears random. The following Figure 3 provides some examples. The output of a hash function, or simply hash, is usually called the message digest and canpossible combinations of people using accounts.

So look at it two-fold. I find a collision in the hash and I find the private key. Now I have to hope my odds are that someone else is using that hash. Since there are more possible hash account numbers than every person every born on this planet and was each using a million addresses, the attack by it's own nature, while interesting, just isn't really feasible on alarge scale.

* * *

2.http://bitcoinmagazine.com/7781/satoshis-genius-unexpected-ways-in-which-bitcoin-dodged-some-cryptographic-bullet/

# 50

## Major Flaw Discovered

A MAJOR FLAW was discovered in the Bitcoin software/protocol that allowed a sender to send invalid transactions, one where the sender creates new bitcoins. By the time it was fixed, several millions of invalid bitcoins had been created. They were later erased from the block chain.

### ***


any script kiddie can figure out how to add two characters and make a new version that disables the alert system. It would be a temporary inconvenience only.

* * *

Quote from: BioMike on August 23, 2010, 05:15:43 AM

So, theoretical this is a first control system where <some goverment> can arrest satoshi and demandthat he hands over his key (or get it from his computer) and shut down the complete network?

* * *

This is what makes me think the people objecting don't know what they're talking about. It can't "shut down the complete network".

* * *

### Re: Development of alert system

Posted by satoshi, August 25, 2010, 04:56:15 PM

* * *

Quote from: BioMike on August 25, 2010, 06:23:45 PM

* * *

Quote from: satoshi on August 25, 2010, 04:56:15 PM

This isI have noticed the pressure in my furnace is causing the relief valve to work. The fluctuation of temp/pressure is:@160 8lbs - @190 22 lbs. I have drained the expansiontank and recharged it..and I still have these fluctations.Is it time for a new expansion tank?


unites all of TipRanks’ equity insights.Disclaimer: The opinions expressed in this article are solely those of the featured analysts. The content is intended to be used for informational purposes only. It is very important to do your own analysis before making any investment.would need to read HTML returned from the gallery website and retrieve image tags. You can use http://github.com/topfunky/hpple/tree/master or http://github.com/zootreeves/Objective-C-HMTL-Parser to parse HTML. For simple HTML this approach should work.
If the HTML is complex then use YQL to scrape the gallery website and convert to JSON.


I. Field
The following description relates generally to wireless communications, and more particularly to utilizing circular buffer based rate matching for transferring data in a wireless communication system.
II. Background
Wireless communication systems are widely deployed to provide various types of communication; for instance, voice and/or data can be provided via such wireless communication systems. A typical wireless communication system, or network, can provide multiple users access to one or more shared resources (e.g., bandwidth, transmit power, . . . ). For instance, a system can use a variety of multiple access techniques such as Frequency Division Multiplexing (FDM), Time Division Multiplexing (TDM), Code Division Multiplexing (CDM), Orthogonal Frequency Division Multiplexing (OFDM), and others.
Generally, wireless multiple-access communication systems can simultaneously support communication for multiple access terminals. Each access terminal can communicateIntroduction
============

The Gram-negative Gammaproteobacterium *Pseudomonas aeruginosa* exhibits a broad metabolic versatility ([@B14]; [@B1]) and exists in a wide variety of environmental habitats ([@B61]; [@B28]; [@B50]). As opportunistic pathogen, *P. aeruginosa* is able to infect different host organisms ([@B57]; [@B32]; [@B51]), and it is a major agent of human infections posing a particular threat to immunocompromised persons and patients with cystic fibrosis ([@B20]; [@B29]). Within a complex regulatory network that allows *P. aeruginosa* to sense and respond to different environmental cues with changes in gene expression, quorum sensing (QS) is a key regulatory system of this bacterium rendering *P. aeruginosa* a model organism for QS ([@B74]; [@B15]; [@B41]).

Quorum sensing (QS), a process of cell-to-cell communication, describes the regulation of gene expression in response to signal molecules, which are mostly membrane-diffusible


*N*-acyl-homoserine lactones (AHLs) in Gram-negative bacteria. Usually, QS is defined to be cell density-dependent, and an increase in cell density is accompanied by an accumulation of signal molecules to a certain threshold concentration, at which the signals bind to the cognate receptor proteins, thereby eliciting changes in gene expression ([@B73]). In *P. aeruginosa*, however, QS is to a large degree co-regulated by environmental signals, mostly nutritional cues, resulting in the differential regulation of QS-controlled genes under different nutrient conditions ([@B67]; [@B70]; [@B5]; [@B21]; [@B55]; [@B54]). In addition to extracellular metabolic information, it is hypothesized that intracellular metabolic influences may be involved in QS regulation as well and that changing ratios of macronutrients may be monitored via intracellular metabolite fluxes ([@B49]).

In this study, we aimed at investigating such extra-resulting shortage of amino acids is integrated via the stringent response, which is a conserved bacterial stress response enabling bacteria to adapt to growth-inhibiting environmental stresses ([@B45]; [@B56]). It is mediated by the guanosine nucleotides pppGpp and ppGpp as regulatory components. Accumulation of (p)ppGpp is regulated by two enzymes, the monofunctional synthetase RelA and the bifunctional synthetase/hydrolase SpoT. In P. aeruginosa, (p)ppGpp is required for full expression of the Rhl and Las systems and negatively regulates the PQS system ([@B67]; [@B62]).

Nitrogen limitation leads to an induction of rhamnolipid biosynthesis via the small RNA NrsZ together with the two-component system NtrB/C and the alternative sigma factor RpoN without involvement of the Rhl system as it was previously suggested ([@B48]; [@B72]). However, upstream regions of both *rhlR* and *rhlI* harbor


triparental mating as described above, and mutants were selected on PIA plates containing tetracycline. Parts of the vector containing the tetracycline resistance cassette were removed from the genome by introducing pFLP2 as described previously ([@B38]), and integration was confirmed by PCR with the primer pair P~ser-up~ and P~ser-down~ ([@B34]).

For complementation of auxotrophic strains of strain PAO1 the ORF of the respective gene was amplified with primer pairs AM/AN for *lysA*, AO/AP for *argH*, and AQ/AR for *hisD*, the resulting fragments were digested with HindIII/XbaI and ligated into the corresponding sites of pBBR1MCS5. The resulting plamids were introduced into the respective auxotrophic strain by transformation ([@B13]).

To obtain chromosomal promoter-*lacZ* reporter gene fusions of *rhlR* and *pqsA*, mini-CTX-*lacZ*\[P*~rhlR~*\] and mini-CTX-*lacZ*\[P*~pqsA~*\] were mobilized into strain PAO1Δ*relA*Δ*spoT* as described previously ([@B38]).

β-Galactosidase Experiments
---------------------------

Expressionand nature in Europe and elsewhere, while also polluting the air, soil and water, which we depend on for our own survival,” said Céline Charveriat, executive director of the Institute for European Environmental Policy, a think tank.

Black Friday started in the U.S. in the 1950s, and landed in the U.K. around the start of the decade when local chains responded to online marketplaces offering big discounts to British consumers.

The trend hit continental Europe even later, with French and German retailers stepping up their participation only in the past few years.

But amid growing awareness of climate warming and global plastic contamination, an increasing proportion of European consumers think about the environmental impact of their purchases, according to survey of online shopping out Thursday from the European Commission.

The survey found


Q:

Texturing deformation through a sequence of meshes

I have several (externally generated) two-mesh sequences representing undeformed/deformed objects.  I would like to visualize these deformations using texture mappings on the meshes.
In particular, I would like to place a texture on the undeformed object, and have it deform along with the mapping to the deformed object.  The mesh connectivity between undeformed/deformed is the same.
Is there an established method for doing this in Blender?  I have heard that this can be done using "shape keys", although I do not know what this means.  I am very new to Blender and graphics software in general, so basic advice is appreciated.

A:

I solved the problem.  I did not use shape keys at all.
This can be done by copying theto variety of stresses from culture medium [@pone.0030415-Marzorati1], and these may include pro-inflammatory mediators released by islets [@pone.0030415-Uno1] and enzymes secreted from contaminating exocrine tissue [@pone.0030415-Lakey1]. All these stresses together may contribute to augment inflammatory or apoptotic pathways within cultured islets. Moreover, the nutrient and oxygen supply of cultured islets is solely dependent on diffusion from the medium. Therefore the central beta-cell enriched core might suffer from hypoxic conditions [@pone.0030415-Giuliani1] resulting in upregulation of genes associated with oxidative stress. In response to hypoxia, cells enhance oxygen delivery by activating genes associated with angiogenesis and glucose metabolism but persistent hypoxia finally activates cell death pathways [@pone.0030415-Hochachka1]. Therefore, the observed upregulation of mediators of cell growth, angiogenesis and glucose metabolism could be part of the hypoxia response. Cultured islets also


and an angiogenic factor, was the most highly induced gene. Interestingly our immunohistochemical studies confirmed that the majority of IL-8 was produced by beta-cells in isolated human islets. Other studies have observed IL-8 production from alpha-cells of type II diabetic patients and from non-endocrine fractions of islet preparations [@pone.0030415-Movahedi1], [@pone.0030415-Ehses1]. While we did not observe colocalization of IL-8 and glucagon, we did observe IL-8 staining in non-beta-cells, suggesting additional sources of IL-8 expression. Earlier studies have shown that islet preparations contain resident macrophages, ductal cells and vascular endothelial cells [@pone.0030415-Linn1] which could be other sources of IL-8 expression in our islet preparations. While the functional consequences of IL-8 production by beta-cells are not known, IL-8 production has been associated with poor outcomes in other transplantation procedures. IL-8 releasecultured islets [@pone.0030415-Sarkar1] and evidence suggests that inhibition of NFKB activity improves islet graft function [@pone.0030415-Rehman1], [@pone.0030415-Chen1]. Our findings have uncovered several NFKB target genes which may mediate the negative effect of this pathway on islet survival.

Cell based therapies for diabetes are severely limited by the inability to properly maintain beta-cells in culture, even for periods of less than a week [@pone.0030415-Russ2]. However, little is known about the processes mediating beta-cell dedifferentiation in culture. Activation of the Notch pathway, which is not normally present in adult human beta-cells, appears to suppress apoptosis as well as promote beta-cell dedifferentiation in culture [@pone.0030415-Bar1], [@pone.0030415-Dror1]. We observed a decrease in the expression of beta-cell specific transcription factors upon isolation and culturing of human islets, including key regulators like NEUROD1, MAFA, and


MAFB. NEUROD1 is required for maintaining maturity and proper functioning in adult beta-cells and beta-cells lacking NEUROD1 resemble immature beta-cells [@pone.0030415-Gu1]. MAFB is required for beta-cell maturation [@pone.0030415-Artner1], whereas MAFA is essential for maintenance and function of adult beta-cells [@pone.0030415-Artner2]. Knock down of MAFA or MAFB results in reduced numbers of insulin producing cells and poor islet function [@pone.0030415-Artner1], [@pone.0030415-Zhang1]. Transcription factors found in endocrine progenitor cells, like SOX4, SOX9, and ID2 were induced during isolation process. The Sox family of transcription factors play a critical role in the maintenance of the pancreatic progenitor cell pool and the development and function of islet cells [@pone.0030415-McDonald1]. SOX4 and SOX9 are required for the maintenance of undifferentiated progenitor cells and endocrine cell pool [@pone.0030415-Wilson1], [@pone.0030415-Lynn1]. Interestingly, there is evidence thatoverall / no skipping.) VG/VG
Botch - We Are the Romans | 2xLP Blue/Orange Vinyl (3rd Press) /250 | Played once, NM/NM.
mewithoutYou - [A-->B] Life | Black Vinyl /1000 (1st press) | Hardly played, VG+++/NM
Also:
maudlin of the well - Leaving your Body Map | 2xLP Black Vinyl Repress | New, unplayed M/M

Looking for any variant of mewithoutYou's Catch For Us the Foxes. One of my favorite albums, just looking to add it to the collection and complete the MWY discography.
I know it's highly sought, but I want to avoid going over $100 if at all possible (we'll see how that goes haha). Message me if you want to make a deal. Thanks, ya'll!

huge mewithoutYou fan here, been looking for the Norma Jean/mewithoutYou split forever and it's the very last


thing I need for my collection before I can move on to variants. If anyone is willing to sell theirs or knows someone willing to sell, please hit me up:)

Hey everyone,
I accidentally ordered 2 of the Circa Survive Juturna Deluxe 10-Year Edition 3-Disc sets a year or so ago. Obviously I don't need 2 so 1 is up FOR TRADE. It's unopened, still in the shrink wrap, boxed and ready to go.
Looking for...
- Mewithoutyou : Catch For Us The Foxes or A-B Life
- Circa Survive: Descensus
- The Dear Hunter: Act IV
- As Cities Burn: Son, I Loved You At Your Darkest or Come Now Sleep
- Bad Rabbits: Stick Up Kids
- Cage The Elephant: Melophobia
- The Mars Volta: any album
- The Receiving End Of Sirens: The Earth Sings Miframe main body 16a at regular intervals.
In the conventional linear compressor, the magnet linearly reciprocates between the inner stator and the outer stator due to a mutual electromagnetic force. However, it is difficult to employ a cylindrical magnet because of a high price of the magnet. Even if several bar-shaped magnets are fixed to form a magnet frame, the unit costs and overall costs of production still increase.
Moreover, in the conventional linear compressor, the linear motor varies a stroke to modulate a cooling capacity according to a load. To this end, a complicated control unit is provided, which is accompanied with design limitations on sizes of peripheral components. Further, a complicated control method is required, which increases the costs of production and complicates a manufacturing process. Furthermore, much


     JIMMY C. STOUT v. RACETRAC PETROLEUM INC.,

                  Appeal from the Circuit Court of Putnam County
                    No. 00N00233 John Maddux, Circuit Court

                                ______________________

                No. M2001-00977-COA-R3-CV - Filed August 27, 2003

Plaintiffs, XI Properties Inc. et al., purchased land from the defendant, RaceTrac, adjacent
to                                           5
period to establish title to the property. Mr. Jakes argued that neither Mr. Michael nor his
predecessor in title had enclosed the driveway or made an an outward possession of the
property. After addressing these issues, we reversed the trial court=s decision that summary
judgment should be granted. Mr. Michael had created a dispute of fact that he had
possession of the land, despite no enclosure, and that his predecessors had possessed the
land. The issue was exactly what portion of the land Mr. Michael or his predecessors had
possessed.


years, may assert a claim of adverse possession, so long as it
was truly adverse, exclusive, continuous, open, and actual, even if the grant of land was by
mistake or ignorance. Therefore, if it is even necessary to state an exception to the general
rule as set out in Mahunda, there is ample precedent and Tennessee hereby adopts the
exception.

           2. If a Grantor is not a Tenant of a Grantee, may a Grantor rely
            on Tennessee Code Annotated § 28-2-103 to assert possession?

         If this case is not governed purely by Mahunda, we can go back again to Tennessee
Code Annotated 28-2-103, the238 (Sup. Ct. 1958), Albert v. Wright v. Thomas & Curley;
410 Pa. 383, 189 A.2d 753 (Sup. Ct. 1963) Henry v. Koch, 1882 WL 8259 (Ct. App. Ky.
1882) are very specific and fact based and create no real precedent for RaceTrac=s theory to
adopt a new definition. In Bradley and Albert, the court gave no relief to the neighbor
landowners for excavations that went into the Afill@ that was placed on the property. In
Henry, there was a common wall, which could not be altered without damage to the other
property. In Durante, an owner with a building erected directly next to property he
conveyed to the defendant, suffered damage when the new owner excavated below the
foundation line of the building. The court found that the defendant took it Aburdened or
benefited by all


which are used in various companies and offices. This Attendance Machine with Access Control systems are used for the purpose of counting the attendance of a particular employee when his/ her access card is inserted in the access card system of the main entrance of the company or office. These systems helps count the exact attendance of the employee and in counting the total office hours spent by him/her in the office and saves the time.

Features:

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Fingerprint capacity: 50000

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and because it continues to plague us now. We need to learn how to live in days like these.

War is from Satan, and peace is from God. In the Book of Mormon, we learn that righteous people never start wars. War sometimes comes upon people who do not deserve it but are subjected to it because of the wickedness of other people. Perhaps paradoxically, the book praises both those who are forced to defend themselves militarily and also those who made a covenant never to bear arms and who would rather die than shed the blood of their brothers. In the Book of Mormon, we learn that those who initiate wars often proclaim high-minded principles, such as the righting of past wrongs (for example, see Alma 54:17–18; 3lessons we should be learning from history, virtually all those who started these tragedies, whether they won or lost, were hailed by their own as heroes, and monuments were built in their honor. Truly, as Jesus foretold of our time, “iniquity shall abound,” and “the love of men shall wax cold” (Joseph Smith—Matthew 1:30).

Not all of the tribulations that people experience in the latter days will be caused by war and political unrest. But because these will likely remain with us now and in future generations, we need to learn how to deal with them. Like the ancient disciples who were tutored by Jesus during the last days of his mortality, we want to know, how can we live in a world of wars and rumors of wars


let him continue to humble himself before God, hungering and thirsting after righteousness and living by every word of God. And the Lord will soon say unto him, ‘Son, thou shalt be exalted.’”[8] In the world to come, faithful Latter-day Saints will enter the divine presence, where “the keeper of the gate is the Holy One of Israel; and he employeth no servant there” (2 Nephi 9:41). There they will be found worthy and will be welcomed home by their Savior, finding ultimate peace in the assurance of eternal life. Some have had assurances while yet in this life (see 2 Timothy 4:6–8; D&C 132:49), but all who will be heirs of the celestial kingdom can feel even now the peace that Jesus brings, not the peace ofwith others. When some of their countrymen expressed dismay that they wanted to teach their “enemies” and argued instead that they should kill them, the sons of Mosiah, in contrast, worked at great personal risk to share with them the gospel (see Alma 26:23–26). It is interesting to note that throughout the Book of Mormon, the righteous call their opposing nation “our brethren,” even in times of war against them (see Jacob 7:26; Mosiah 22:3; Alma 56:46). Joseph Smith taught that one who is “filled with the love of God, is not content with blessing his family alone, but ranges through the whole world, anxious to bless the whole human race.”[10] Those filled with God’s love do not know national or ethnic boarders for their love. They truly


Jose Mourinho Hints That Petr Cech’s Chelsea To Arsenal Move Was Out Of His Control

Petr Cech is set to become an Arsenal player within the next few days, with many newspapers reporting online today that the deal is already done.

The Czech Republic goalkeeper – who has spent 10 years at Stamford Bridge – will join the Gunners in a bid to play as much first team football as he reaches the twilight of his highly successful career.

The 33-year-old stopper has become second choice this season with Jose Mourinho opting to play young Belgian keeper Thibaut Courtois ahead of him for most of their title-winning campaign.

But did the Blues boss drop a major hint earlier in the month suggesting that the deal was completely out of his hands?

BT Sportreporter and presenter Jake Humphrey tweeted a video this afternoon from an interview with the former Inter Milan and Real Madrid gaffer during the channel’s Champions League launch show.

And Mourinho – carefully worded as ever – explained that he would never want Cech to leave the club, even if it meant disagreeing with the ideas of owner Roman Abramovich.

You can check out the video in the tweet below.

Cech is currently the holder of the all-time Premier League clean sheets record with 168 shut-outs to his name.


later on today-Malawi Digest.

The ruling Democratic Progressive Party (DPP) of Ngwazi Dr Bingu wa Mutharika has overwhelmingly won the Lilongwe North West with Fredrick Kamwangala as it’s new Member of Parliament.

Kamwangala, beat three other contestants in Zelesi Gomani independent, Robert Bondo of the opposition Malawi Congress Party of John Tembo and Selemani Jeremiah.

According to election results released by independent Malawi Electoral Commission, Kamwangala got 11, 558 votes with Gomani following way behind with 2,952, Bondo in third position with 2, 758 and Jeremiah in forth position with 653 votes.

The opposition UDF party chickened out of this contest as they failed to have a candidate in this by-election.

This is a sweetie victory for the ruling DPP after the death of late Ishmael Chafukira who died under mysterious circumstances in float thresholdCompliance = smoothstep(lowerThreshold, upperThreshold, currentGradientAndDirection.r);
     multiplier = multiplier * thresholdCompliance;

     gl_FragColor = vec4(multiplier, multiplier, multiplier, 1.0);
 }
);
#else
NSString *const kGPUImageDirectionalNonmaximumSuppressionFragmentShaderString = SHADER_STRING
(
 varying vec2 textureCoordinate;

 uniform sampler2D inputImageTexture;
 uniform float texelWidth;
 uniform float texelHeight;
 uniform float upperThreshold;
 uniform float lowerThreshold;

 void main()
 {
     vec3 currentGradientAndDirection = texture2D(inputImageTexture, textureCoordinate).rgb;
     vec2 gradientDirection = ((currentGradientAndDirection.gb * 2.0) - 1.0) * vec2(texelWidth, texelHeight);

     float firstSampledGradientMagnitude = texture2D(inputImageTexture, textureCoordinate + gradientDirection).r;
     float secondSampledGradientMagnitude = texture2D(inputImageTexture, textureCoordinate - gradientDirection).r;

     float multiplier = step(firstSampledGradientMagnitude, currentGradientAndDirection.r);


disregard of its spirit."
After due consideration, we are of opinion that sound judicial discretion does not warrant the exercise of such power at this time. In view of the efforts that are being made  we assume in good faith  by this municipality to provide to the limit of its power for the equality of treatment to all bondholders, we vacate the mandamus order granted, but direct the court to retain jurisdiction of the petition for the present.
NOTES
[*]   Writ of certiorari denied United States ex rel. Christmas v. City of Asbury Park, 56 L. Ed. 147, 80 L. Ed. ___.
Q:

what does document.createElement('a') do in this code?

I found some code to get parameters in the form ?a=1&b=2 from a URL but there are parts I don't understand.
I can work out the last part to some degree - he is splitting the string on "&" and then extracting the parts on either side of the "=" sign.  I don't quite understand the decodeURIComponent function, I looked it up and am still confused.  The main problem, though, is these three lines:
var parser = document.createElement('a');
parser.href = window.location.href;
var query = parser.search.substring(1);

How does making a non-existant element work, why can he do parser.href and why do parser.search.substring(1)?
full code:
function get_params() {
    var params = {};
    var parser = document.createElement('a');
    parser.href = window.location.href;


that a collective "steals" from the individual is absurd, as the individual's wealth creation is dependent on the collective working together.

Examples of Anti-Communist terror are rarely acknowledged. Consider Suharto's purge of Indonesia in 1965 resulting in a million deaths, or the Dirty War in Argentina resulting in 30,000 "disappeared", or the Vietnam War resulting in two million civilian deaths.

The other issue often brought up is the death toll produced by Communist states. Obviously this is factual, but in the Cold War it was not one sided. The truth is that both the USSR and USA were responsible for mass-murder, committed to enforce their regional influence.

If it were just that Communism murders people, then this disapproval could not be uniquely against Communism. Which doesn't explain anything. Similarly it isn'tArchive

On July 22, Metropolitan Psychological Corporation (MPC) will be holding its second talk for 2016 entitled, “Self-Injurious Behaviors among Adolescents: Assessment and Interventions with Dr. Ma. Teresa Gustilo-Villasor.”

This event will be held at the Ateneo Professional Schools – Ateneo de Manila University in 20 Rockwell Drive, Rockwell Center, Makati City from 9 AM – 4 PM (Friday).

Promo for talk on “Self-Injurious Behaviors among Adolescents: Assessment and Interventions.”

#DameTimeManila Press Conference – Clockwise: Adidas pulls out all the stops on this incredible backdrop. | A smiling Damian Lillard. A rare shot considering his stoic demeanor. | As close as I could get. | Thank you Adidas Philippines for this awesome backpack. | Thanks to NextJam for the souveneir ticket. | A photo of the Media Registration tarpaulin at the Kerry


Sports Arena.

It was past two in the afternoon when Damian Lamonte Ollie Lillard, the Portland Trailblazers dynamic 6’3’’ point guard, made his way to the seating area of the Kerry Sports Arena in Shang-ri La The Fort, Bonifacio Global City for his Manila press conference. The two-time NBA all-star took several questions from the media and this was what I asked him:

Dr. Tedi Villasor: “Hi Dame. We have a lot of aspiring high school, collegiate, and professional (basketball) players. Could you give us in your opinion what are the five qualities that they should possess to be really good basketball players?

Damian Lillard: “Off the top of my head, I would say that number one would have to be character. If you have high character, you work hard, beis yours for £7.48 - and why not pair it with a 45% decrease in your team deathmatch respawn time? £1.29, but you'll only be able to use it for 7 days. Gloves are the money-grubbiest of optional purchases: six pairs, mostly indistinguishable to all but the keenest-eyed hand fanatics, for more than a quid a pop.

Price and availability Free to play on Steam

There are no direct weapon power perks, but buffs such as reduced respawn time or an increase in killstreak rewards make paying players unequivocally better than vanilla free-to-players. It's a bonus that Tactical Intervention doesn't feel truly pay-to-win, but a large chunk of that comes from how chaotic and confused the game is at a base level: unlike Counter-Strike, it's not balanced well enough to


prime number?
True
Is 8805649 a prime number?
True
Is 13010087 composite?
True
Is 3164307 composite?
True
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False
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False
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True
Is 13588309 a prime number?
False
Is 528439 composite?
True
Is 28120909 a prime number?
False
Is 17386961 a prime number?
True
Is 392002519 composite?
False
Is 141705437 composite?
False
Is 6446899 a prime number?
False
Is 52685507 composite?
True
Is 2092918 a prime number?
False
Is 3063593 a composite number?
True
Is 76277171 composite?
False
Is 409311449 prime?
True
Is 135365953 a composite number?
False
Is 212786591 a prime number?
True
Is 1804063 composite?
False
Is 51704113 a composite number?
True
Is 4075987 composite?
False
Is 39834491 a prime number?
True
Is 141418649 a prime number?
True
Is 5963317 prime?
True
Is 2444671 a composite number?
True
Is 1271903 a prime number?
True
Is 110092757 a prime number?
True
Is 16857041 a composite number?
True
Is 1860251 composite?
False
Is 12392713 composite?
False
Is 7076317 a composite number?
False
Is 487379 prime?
False
Is 798017 a composite number?
True
Is 20529673 a prime number?
True
Is 120828107 a prime number?
False
Is 97257253 a prime number?
True
Is 349241 a composite number?
False
Is 236171255 composite?
True
Isconducted by Trend Survey and Research Co., Ltd. (趨勢民意調查公司) at the behest of the Taiwan Brain Trust (新台灣國策智庫).

As to the motives behind the Panama break, 46.3 percent said China was breaking its promise of peaceful development of cross-strait relations and imperiling the status quo, while 35.5 percent said Tsai’s refusal to accept the “1992 Consensus” that there was one China was behind the switch.

If the president decided to adapt her promise of maintaining the status quo in relations with China, 65.4 percent said they would support her, while if it were impossible to hold on to the status quo, then 54.8 percent said Taiwan could be independent to become a country, the poll found.

The break with Panama had a negative influence on relations with China, said 58.7 percent


it. I’ll take this opportunity to also unreservedly recommend Cordelia Fine’s excellent “Delusions of Gender”, which is an absolutely kickarse primer in how gender is socially constructed, and also happens to be a marvellously engaging read.
– Sarah

The book is a collection of essays, interviews and articles from non-theistic pagans exploring the different aspects of being a godless pagan. The book is diverse, thought provoking and often quiet inspiring. The writers explore topics as diverse as scientific paganism, emotional pantheism, faith in the earth, non-liiteral deities, non-theistic pagans in history and most importantly, the godless pagan’s place in the broader pagan community.
– Fran

It’s Winter. What that means in a practical sense is that I make a lot of tea and soup, and sit by the heater at night readingcosy books about English Paganism to kid myself that Winter is actually a necessary part of the wheel of the year, and not personally out to get me and make my life a misery. As far as coping mechanisms go, it’s a relatively harmless one and I make pretty good soup. And I end up with a lot of my bookshelf real estate occupied by Capall Bann publications like this one. Now you know my weakness; if I ever go on a mad rampage, you can throw a random Capall Bann title down in front of me and I shall be pacified.
So yeah, this book. It’s quirky, and charming, and surprisingly salty, despite its “Oprah’s Book Club” style cover (no one would mistake this for, say, a Three


will know her then. She will be its trophy and its sacrifice. She must make her peace with her birthright, whatever that means.”

So begins Jeanette Winterson’s novella about the Lancashire Witch Trials of 1612.

Winterson, whose interest in the occult and Elizabethan magic has been a recurring theme throughout her career, wrote this story for the 400th anniversary of the trials, and blends well-researched history with local legend and her trademark poetical magic realism to weave a tale that includes not only the Pendle Witches and their accusers, but also John Dee, Edward Kelley and William Shakespeare. She explores the religious and sexual politics of the age, as well as the personal disputes that background the trials, and weaves those seamlessly with the high magic and folk magic ofcommittee be able to maintain their jobs and relationships, it was unanimously voted in that we will no longer chase up events, and will rely instead on event organisers providing us with information. This may mean that some events are no longer advertised but on the plus side the committee will be able to spend time with their families.

In the light of our focus on safe spaces, this may also change our advertising policy but at present none of the events we advertise have been flagged as potentially problematic, so we will implement the new calendar policy as previously described.

Samhain

The public PCV Samhain ritual is being hosted by Seline and it is going to be on the 30th of April. At the moment that is what is known,


on the FB group due to time constraints today.

Possibly we should consider having ‘Newvember’ and have a newbie month or perhaps ‘NeoVember’ where we make sure that we run stuff that is ultra-inclusive as part of this.

Yule Dinner

It looks like it might be at the Last Jar on the 24th June, probably 2 courses to cut costs and make tickets more affordable.

A subcommittee shall be formed to help organize – Sub-committee – Ryan, Alex, Sarah, Josie, Mark (decorations), Ange (decorations) and shall liaise further to get this rolling.

The community expects more than sausage. They want custard or a Chikko Roll.fixed contact terminals or at least their fixed contacts are disposed to oppose each other, as shown in FIGS. 1A and 1B, the fixed contact terminal 3' and movable contact terminal 7' are prepared jointly in a single metal strip S' together with a coil terminal 9'. However, the other fixed contact terminal 4' must be prepared separately from the strip S' since it has been practically impossible to provide in the same strip the latter terminal 4' which is to be disposed in the opposing relation with a predetermined space to the former fixed contact terminal 3'. Yet, so long as at least the terminals 3', 7' and 9' are formed in the strip S', the manufacture of the relay is adapted to an automatic line operation


that could not have been raised in the first motion and she failed to show cause for excluding them from her first motion.  The district court adopted the magistrate judge's report and recommendation and denied the motion.
A district court may deny a second § 2255 motion as abusive or successive unless the defendant "excuses his failure to raise the issue earlier by showing cause for failing to raise it and prejudice therefrom or by showing that a fundamental miscarriage of justice would result from a failure to entertain the claim."  United States v. Richards, 5 F.3d 1369, 1370 (10th Cir.1993)(quotation omitted).  Ms. Davis contends that she should be excused for her successive § 2255 motion because she "became knowledgeable of the facts [only] after shethey are auxotrophic in terms of uridine and pyruvate requirement for growth. Although various metabolic pathways are impaired, these cells are resistant to apoptosis in response to stimuli that induce this type of cell death in normal cells \[[@B6-pharmaceuticals-07-00913]\]. This is an illustrative example of the role of mitochondria in cell physiology.

2. Role of Mitochondria in the Etiology and Onset of Human Diseases
===================================================================

Mitochondrial dysfunctions underlie many severe pathologies, such as malignant transformation and cancer development, as well as neurodegenerative disorders and type 2 diabetes \[[@B7-pharmaceuticals-07-00913],[@B8-pharmaceuticals-07-00913]\]. The pathologies associated with mitochondria can either result from the inherited or acquired mutations within the mitochondrial genome or the cause may lie in the mutated nuclear genes that encode proteins involved in respiration or the mtDNA maintenance. Due to the large number


observed in renal epithelium, cardiomyocytes, neurons and brain tissue, retinal pigment epithelium and other cells \[[@B64-pharmaceuticals-07-00913],[@B65-pharmaceuticals-07-00913],[@B66-pharmaceuticals-07-00913],[@B67-pharmaceuticals-07-00913],[@B68-pharmaceuticals-07-00913]\]. For example, neuroprotective action of resveratrol was described in the brains of rats subjected to hypoxia/reoxygenation induced injury, and additionally it significantly accelerated the regeneration of mitochondria after the administration of synthetic uncoupler, CCCP \[[@B69-pharmaceuticals-07-00913]\]. Interesting neuroprotective effects are exerted by resveratrol in traumatic brain injury, as well as LPS challenge and involve anti-inflammatory activity towards microglia, manifested by downregulation of IL-1, IL-6, IL-12, TNFα and nitric oxide release \[[@B70-pharmaceuticals-07-00913],[@B71-pharmaceuticals-07-00913],[@B72-pharmaceuticals-07-00913]\].

These cytoprotective effects, however, are not observed in cancer cells, which respond to resveratrol with impairment of mitochondrial function, disruption of calcium homeostasis that leads to calcium-induced calcium release (CICR) from mitochondria; opening of membrane permeability transition pore and apoptosis in consequence \[[@B73-pharmaceuticals-07-00913],[@B74-pharmaceuticals-07-00913]\].These opposite effects observed in malignant *vs.* nontransformed cells suggest that there are distinct physiological features that differentiate the response to the same molecule in these two cellular environments. The possible reason of such contrasting outcomes could involve different basal intracellular ROS level (lower in healthy cells with fully functional mitochondria) and the efficiency of antioxidative protection mechanisms, particularly glutathione levels, catalase, superoxide dismutases activities, *etc.* (which are usually lower in transformed cells).

The case of curcumin activity may be similar, since there are numerous reports showing its antioxidative properties, as well as conversely, demonstrating the striking elevation of the generated ROS. For example curcumin was shown to induce mitochondrial damage and subsequent apoptosis in lung cancer cells, Jurkat cells or mouse fibroblasts \[[@B75-pharmaceuticals-07-00913],[@B76-pharmaceuticals-07-00913],[@B77-pharmaceuticals-07-00913]\]. Cytoprotective effects of curcumin against


glutamate levels, that suggest it acts as a metabolic sensor. In yeast, Rtg proteins play role in integration of metabolism and mitochondria maintenance by: (1) upregulation of peroxisomal glyoxalate cycle for oxidation of fatty acids, (2) sustaining anaplerosis via truncated Krebs cycle that provides intermediates for glutamate and lysine biosynthesis, (3) activating aconitase as a bifunctional Krebs cycle enzyme but also stabilizing mtDNA \[[@B106-pharmaceuticals-07-00913]\]. In mammalian cells the retrograde response is much more diverse and less well defined, but comprises several main events, such as upregulation of some nuclear encoded mitochondrial proteins (citrate synthase, cytochrome oxidase CoxVa) and non-mitochondrial like cytoskeleton (β-actin), glycolytic (GAPDH) or signaling (c-Myc) proteins. Other symptoms of retrograde response involve imbalanced calcium homeostasis, elevated cytoplasmic Ca^2+^ levels, increased expression of endoplasmic reticulum calcium releasenuclear encoded proteins to sustain the proper functions of mitochondria. The mitochondrial translation machinery, including mitochondrial ribosomal proteins (Mrps) is necessary not only for biosynthesis of these 13 proteins, but also for maintaining a particular stoichiometric ratio between nuclear and mitochondrial respiratory proteins. Alteration of this ratio creates a stimulus that triggers mitochondrial unfolded protein respose (UPR^mt^). The fact, that some antibacterial antibiotics, as well as ethidium bromide, specifically inhibit transcription, is fundamental to experimental approaches developed to study unfolded protein response. In the interesting study by Houtkooper *et al*. \[[@B116-pharmaceuticals-07-00913]\], the authors show that unfolded protein response determines longevity in various eukaryotic organisms. The study revealed that Mrps5 expression level decreases with age and moreover, the knockdown of this gene during developmental stage extends the lifespan of


2016

On "the franchise": 'Tavares isn't becoming a free agent'

When Shannon Hogan made reference to John Tavares hitting free agency two summers from now, Ledecky interrupted: "What?" "What was one of the best moments in Islanders history last year? When Tavares scored in double-overtime and blew the roof off this place, the scoreboard almost became centered.

"He's not going to be a free agent."

I asked John Ledeky outright if he will forever retain Tavares. He said they'll manage the cap well and he will always be an islander... — Michael (@InterviewKing1) July 15, 2016

"The scoreboard almost became centered." -Ledecky on Tavares' 2OT goal #isles — Islanders Insight (@IslesInsight) July 14, 2016

Oh, by the way, Casey Cizikas was asked about The Commute, because that is somehow a question asked of everylasting display of orange seed capsules
with black bird-attracting seeds.• Popular street tree. Commonly planted in Highfields gardens.• Well drained soil. Full or part sun. Drought hardy. Best if mulched. Frost hardy to 7°C

Callitris baileyiBAILEY'S CYPRESS• Slender tree to 12m.• Columnar form, with green foliage to ground level. Good for formal plantings, or as a tall screen.• Rare and threatened local native plant.• Well drained soil. Full sun. Drought hardy. Tolerates light frost.

Allocasuarina littoralisBLACK SHE-OAK• Fast growing small tree to 8m.• Dark, fissured bark.• Separate male and female trees. A small group planted 40cm apart forms a single canopy and is likely to have trees of both sexes.• Black cockatoos feed on seeds in woody cones on female trees.• Well drained soil. Full sun. Very drought hardy. Frost resistant.

Hymenosporum


flavumNATIVE FRANGIPANIFast growing small rainforest tree (6-10m) with masses of very fragrant, yellow/cream flowers in spring. Popular garden specimen tree.Strong winds may damage the branches.Responds well to fertilising and mulch. All soils. Full or part sun. Moderately drought hardy. Tolerates moderate frosts.

Flindersia collinaLEOPARD ASH• Medium tree 15-20m. Well shaped, rounded canopy gives dense shade.• Masses of small white fragrant flowers in November attract butterflies and insect-eating birds.• Will grow on poorer soils. A good timber tree. Butterfly host.• Well drained soil. Full or part sun. Drought hardy. Best if mulched. Tolerates some frost.

Brachychiton acerifoliusFLAME TREE• Medium tree to 10m. • Spring leaf drop followed by spectacular display of red flowers in November. Looks very good if planted with silky oak, which flowers at the same time.• Fast growingdry times. • Good container plant when young• Most soils. Full or part shade. Drought hardy. Tolerates light frost, but needs shelter from frost when young.

Cordyline rubraRED FRUITED PALM LILY• Rainforest understorey plant to 2m• Large panicles of delicate mauve flowers. Showy red berries.• Grows best if mulched and given some water in dry times. Good container plant when young• Most soils. Full or part shade. Moderately drought hardy. Tolerates light frost, but needs shelter from frost when young.

Tuesday, February 17, 2015

We are very fond of our hive. It was given to us after its discovery in a felled tree, and we made this nice little position for it, facing north-east and sheltered from most of the heat of the summer sun. In winter, the different sun angle


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UDA ConstructionOnline is the world's fastest-growing platform for construction professionals. Used by over 550,000 construction professionals in 75 countries worldwide, UDA software manages over $65 billion in projects every day.a railway platform. A few old Jews are smoking their pipes. Their pipes smell of scorched horn. Squealings and screechings of children in the corners. Sighs disappear down the cracks between the floorboards. The reddish sheen of an oil lamp battles its way through a veritable wall of smoke and sweat.

Geza Fürst can't stand it anymore. He thrusts his hands into his frayed jacket pockets, and—a tune on his lips—goes out on the street to get some air. Maybe tomorrow he'll get a place in the hostel on Wiesenstrasse that's been set up for homeless Eastern Jews. If only he had papers. Because they're very strict over on Wiesenstrasse; they won't just take anyone who turns up.

All in all some fifty thousand people have come to Germany from