Thus, a good way to measure if asking a question is good or bad is by focusing on the expected number of players left after that question is answered, with the best questions those that minimise the expected number of players left behind. If we focus on the expected number of characters left behind after asking a particular question, like ‘earrings‘ we get

$$\mathbb{E}[\text{earrings}] = \binom{\text{ characters} } {\text{w/earrings}} \times \mathbb{P}[\text{earrings}] + \binom{ \text{characters} } {\text{w/o earrings}}\times\mathbb{P}[\text{ no earrings}] $$

giving us

$$\mathbb{E}[\text{earrings}] = 2 \times \frac{2}{24} + 22 \times \frac{ 22}{24} = 20.3$$

Therefore, after asking ‘earrings‘ we expect to have a bit more than 20 people left. If we just hope that the character our opponent has is either Anne or Maria (the two with earrings), then, in the terminologybut noted in any case that a definition that may be apt for the pure law of sales of goods may not be apt for the purposes of the Regulations, as there were a number of supplies that were now caught by the Regulations (utilities being an obvious one) that are not caught by the Sale of Goods Act definition.

He thought it was relevant that in common parlance a piece of sophisticated, commercial non-bespoke software is regarded as a product. While not falling squarely within the definition of goods in the Sale of Goods Act sense, it was not obviously a service either. Waksman J said whether a software product is delivered on tangible media or electronically was not relevant, stating: "the essential characteristics of a piece of


how can an investor hope to become rich in the finish?

To get the most gains out of your penny stock investments, its important that you pick up details about particular organizations before the news hits the major media stream. As soon as word is generated about a business, the value of the penny stock soars until it no longer falls in the category of penny stocks at all. So how do you get this sort of information if the media isnt disseminating it to the public however?

You need to do your personal due dilligence on the penny stock.As penny stocks are not followed by the principal stream mutual funds you can generally get in prior to they do.

You have to turn into an investigator of sorts and figurethe low stock expense, since once investors know for confident that a organization is on the rise, everyone will be scrambling for a share and the stock rates will rapidly climb.

One way to remain abreast of up-and-coming penny stock organizations is to join 1 of the numerous penny stock assistance forums on the Internet and watch what others have to say about the selections readily available to penny stock investors.


that his whole paper was an analysis of the D&D 9 alignments system.

The second to last idea in Cram's OP reminded me of an idea I had- the story follows a young boy without any sort of psionic powers in a world where telepaths are the norm. He's seen as if he were blind or deaf, and has to learn to cope with everyone else knowing what he's thinking all the time.

Logged

Formerly known as the Space Pope (then I was excommunicated), Father Kurt Christ (I was deemed unfit to raise children, spiritual or otherwise), and Vartox (the speedo was starting to chafe)

In the not-too-distant future, the decision is made to link parliamentary candidates to tabloid celebrities in an attempt to improve voter turnout. The corpses of Jade Goodyif Barclays makes you apologise for flying the rainbow then they’ve no business flying it in the first place. The whole POINT of [Pride] is to not apologise for our existence.”

While @Susan_Larson_TM tweeted: “WTF Barclay’s this kowtowing to homophobia. If he doesn’t wanna use the app tell him to come in, in person. Or send his business elsewhere. Good luck finding one that isn’t taking part in Pride though.”

On realising that the apologies were not well received by the LGBT+ community, Barclays later changed its responses on Twitter to align with their LGBT-supportive message.

We’ve changed our logo to celebrate all of the Pride events that we’re supporting. We believe people should be free to be who they are and love who they love. While homophobia, biphobia and transphobia


the exercise of some of his functions and duties, such as the
use or withholding of the Royal Assent from legislation; history
shows many examples of Governors General using their prerogative
and executive powers. The monarch or Imperial government could
overrule any Governor General, though this could often be
cumbersome, due to remoteness of the territories from London.

The Governor General was also the head of the armed forces in
his or her territory and, because of the Governor General's control
of the military, the post was as much a military appointment as a
civil one. Indeed, until the late 20th century, the Governor
General's official attire was the court dress, Windsor uniform or other military
uniform.

In some colonies, the title of the royal representative was
never Governor General. The King's representative in New Zealand, for
instance, was simply titled Governoruntil after the country became
a Dominion.

Modern
Commonwealth

Advertisements

Independent Commonwealth
realms

Following the Imperial Conference, and subsequent
issuing of the Balfour
Declaration in 1926, the role and responsibilities of the
Governor General began to shift, reflecting the increased
independence of the Dominions (Which were in 1952 renamed Realms;
a term which includes the UK itself). As the sovereign came to be
regarded as monarch of each territory independently, and, as such,
advised only by the ministers of each country in regard to said
country's national affairs (as opposed to a single British monarch
ruling all the Dominions as a conglomerate and advised only by an
imperial parliament), so too did the Governor General become a
direct representative of the national monarch only, who no longer
answered to the British government. These concepts were entrenched
in legislation with the enactment of the Statute of Westminster in
1931, and


+/- 4.27 microns) was significantly larger (P < 0.0001; Wilcoxon-Mann-Whitney test) than their size at the level of the bipolar cells (inner plexiform layer: 3.79 +/- 1.30 microns). The count of CA in sections from non-glaucomatous subjects aged 2.5 to 78 years (45 eyes with malignant melanoma and 6 autopsy eyes) increased significantly (P < 0.01) with advancing age. CA occurred significantly more often (P < 0.0001) in eyes with melanoma (45.7 +/- 29.4 per section) than in eyes with glaucoma (4.7 +/- 6.9 per section). These results suggest that CA represent intraneuronal aging products that are diminished in eyes with end-stage glaucoma due to neuronal loss.that 50 per cent of British adults thought that Trump's immigration ban was a bad idea, compared to 29 per cent who said it was be a good idea.

The poll also asked repondents whether they would be happy for a similar ban on refugees and immigrants entering the UK. 49 per cent of British adults said they would be disappointed were Theresa May to adopt a similar policy, while 27 per cent said they would be pleased.


Meta-analysis: pre-operative infliximab treatment and short-term post-operative complications in patients with ulcerative colitis.
Infliximab was approved for use in ulcerative colitis in recent years. It has been debated if infliximab increases the risk of post-operative complications in patients with ulcerative colitis. To perform a meta-analysis that examines the relationship between preoperative infliximab treatment and short-term post-operative complications in patients with ulcerative colitis. We searched the PubMed and MEDLINE databases to identify observational studies on the impact of pre-operative infliximab use on short-term post-operative complications in ulcerative colitis. Infectious complications mainly included wound infection, sepsis and abscess, whereas non-infectious complications included intestinal obstruction, thromboembolism and gastrointestinal haemorrhage. Pooled odds ratios (ORs) were calculated for each relationship. A total of 5 studies and 706 patients were included in our meta-analysis. Overall,Versteeg: From AuBox I have learned that the community genuinely wants to help people in need and give this plant the respect it deserves. But the laws and regulations from county to county, state to state, and country to country are a complex web of laws that vary depending on where one is. I also saw that there were problems trusting every supplier with lab results, I saw there was not one central data base for grower’s information like what the pH levels of the soil were to if it was grown indoor or outdoor, even patient ID’s are scattered all over the place and not able to be found in one central database, I found out the hard way that it is difficult to rent office space


Pierce by Dorothy Mershon, widow of Gordon Kent Mershon, who alleges her husband's contract as district energy manager was not renewed for the 2009-10 school year because he was 64 years old.

Gordon Mershon died of a heart attack Sept. 23, 2010, at age 65; the lawsuit claims the death was "a direct and proximate result of the defendant's wrongful conduct."

According to a district court document, the case is scheduled to go to trial during the two-week period beginning Sept. 24 in Fort Pierce.Welcome to Revolution Wrestling Alliance

The RWA Tag Team Champions Contract Killers took on The Totem Pole of Love in a first-ever Casket Match at RWA Halloween Haywire. Tricks, treats, and coffins slams – did they defend the gold or lose it all? For more RWA action, check us out on Facebook, Twitter, and YouTube!

After accepting Damon Knight’s offer to join the Contract Killers, Garrisaon Creed stepped into the ring against Moses Mayhem, intent of exiting the new RWA US Champion. Moses Mayhem had different plans. For more RWA action, check us out on Facebook, Twitter, and YouTube!

At Halloween Haywire, Garrisaon Creed battled Spider Baby in a Halloween-style Four Corners Match. At the end, Damon Knight of the Contract Killers made a special appearance, with an offer to Creed


bar represents one step of six consecutive extractions with KCl: the first, second and third extraction took 1 h each, the fourth took 20 h, the fifth 48 h, and the sixth took 95 h. Error bar represents 1 S.E. of the total extraction carried out in triplicates

Spectromicroscopy and mass spectrometry {#Sec4}
---------------------------------------

First, we used^13^C solid-state nuclear magnetic resonance (NMR) spectroscopy, X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) to identify co-composting-induced changes in biochar carbon speciation on the bulk level and structural and chemical changes of the biochar surface. NMR spectroscopy did not reveal significant differences in C speciation between BC~prist~ and BC~comp~ on the bulk level (Supplementary Fig. [1](#MOESM1){ref-type="media"}). In line with this, bulk XPS, i.e., XPS of biochar particles powdered and sieved to 100 µm, only showed a minor increase inNova 2000 provided by Quantachrome Instruments (Boynton Beach, FL, USA) was used. Several methods were applied to the isotherms in order to derive pore surfaces areas and volumes, which are included in the NovaWin software (Quantachrome Instruments). In the case of N~2~ adsorption, the Brunauer, Emmett and Teller (BET)^[@CR41]^ method was used to determine the total internal SSA of the samples. The DFT (density functional theory)^[@CR42]^ method was applied to the adsorption isotherm to characterize the pore size distribution, in particular, the QSDFT (quenched solid-state functional theory) method, considering slit/cylindrical pores. With this method, micropores and mesopores up to \~34 nm in pore width could be measured. The Barrett, Joyner and Halenda (BJH)^[@CR43]^ method was applied to characterize mesopores bigger than \~3 nm and macropores up to the detectable limit


held for a fixed time at the *ω* ~L~ value of 7.2 MHz. The ^1^H 90° pulse was needed to make magnetization observable and the free induction decay acquirable. A time domain of 100 µs sampled with 1000 points was applied. Field-switching time was 3 ms, while spectrometer dead time was 15 µs. For all of the experiments a recycle delay of 20 s was used. In the PP sequence, a polarization field (*B* ~POL~) set at the *ω* ~L~ of 9 MHz was applied prior to each *B* ~RLX~ field. The period of time during which *B* ~POL~ was applied (referred to as polarization time or *T* ~POL~) corresponded to five times the *T* ~1~ estimated at this frequency.

The crossover field between NP and PP sequences was approximately retrieved when the relaxation field intensitysample heterogeneity resulting in a multi-exponential behavior of the decay/recovery curves^[@CR31]^, can be considered as a superposition of exponential contributions, thereby describing the likely physical picture of some distribution in *T* ~1~. Eq. [1](#Equ1){ref-type=""} has the advantage that it is able to handle a wide range of behaviors within a single model. For this reason, assumptions about the number of exponentials to be used in modeling nuclear magnetic dispersion (NMRD) data are not necessary. The NMRD profiles resulting from the elaboration of the decay/recovery curves are reported in Supplementary Fig. [13](#MOESM1){ref-type="media"}. The data acquired at the relaxation field of 0.01 MHz were transformed by applying the Uniform PENalty regularization (UPEN) algorithm^[@CR31]^ which allowed the achievement of the distribution of the longitudinal relaxation times (also referred to as relaxograms).

Liquid chromatography organic carbon detection {#Sec25}
----------------------------------------------

1 g


too is the rest of Creation, each part as is fitting. And yet, we do not see the fulfillment of this. We can see patches of the world that have been so transfigured, in part anyway, but the world as a whole is still broken, is still parched desert. This is why we wait. We wait for the return of Christ, for the free-flowing of this river that gives life and deifies the Cosmos. In the mean time we must do our part to spread it, to do the will of God in transfiguring his Creation, to make his name holy, to bring about his Kingdom here on Earth as it already exists in Heaven.(in-place computaion), we first compute param backward to
  // keep top_diff unchanged.
  if (this->param_propagate_down_[0]) {
    Dtype* slope_diff = this->blobs_[0]->mutable_gpu_diff();
    int cdim = channels * dim;
    Dtype dsum = 0.;
    for (int n = 0; n < bottom[0]->num(); ++n) {
      // compute element-wise diff
      // NOLINT_NEXT_LINE(whitespace/operators)
      PReLUParamBackward<Dtype><<<CAFFE_GET_BLOCKS(cdim),
          CAFFE_CUDA_NUM_THREADS>>>(
          cdim, top_diff + top[0]->offset(n),
          bottom_data + bottom[0]->offset(n),
          backward_buff_.mutable_gpu_diff());
      CUDA_POST_KERNEL_CHECK;


creditor was indeed secured and thereby had standing to bring the motion.
The most logical and legally sensible answer to this question is that the Debtors' failure to perform the duties imposed within Section 521(2) provides grounds for vacating the automatic stay, and that is a remedy Sears may pursue if it chooses to do so, and, indeed, if it is necessary to do so.[4] This remedy is in unison with the several other courts addressing similar motions involving Sears. See In re Weir, 173 B.R. 682, 693 (Bankr.E.D.Cal.1994);[5]Tameling, 173 B.R. at 628-29; Bracamortes, 166 B.R. at 162.[6]But see In re Green, 119 B.R. 72, 73-74 (Bankr.D.Md.1990) (dismissing the case under Section 707(a)(1) for failure to comply with court order requiring debtor to file statement of intention).

* * *this for the money” – essentially he’s renting out his qualifications to the PR firm. The travel firm had chosen this date because it was the date they wanted people to start booking their holidays, and it was a cheap way of getting lots of national newspaper coverage (compared to advertising).

There’s an argument about validity here – arguments can be valid, but not true, and statements true, but not valid. Cliff Arnall’s argument is valid like so;

1: The day that maximises this equation is the most depressing day

2: January 18th maximises the equation.

C: Therefore January 18th is the most depressing day.

Sadly, his first premise is false, as his equation is utter bollocks, but there’s a second point – it’s possible to have a true conclusion even when all


of the liberal mind, throwing to one side or another.

Already I feel my mental weakness growing, the need to buck authority (which I’ve never needed before, seeming to have a knack in that particular field. Amazing what a loose tongue, no dress sense and touch of sociopathy can do for your anarchist credentials) flourishing in the environs so arid of common sense. I am a pluralist, and this commitment to good and bad, doesn’t fit. My only commitment is to diversity of moral opinion, which comics ultimately cannot adhere to, because there’s no sticking ground to plant your banner, because their users need rigidity and solidity of opinion to support them, make them think they’re living those right lives again.

Secondly, there’s social connotations to comics, which do seemagainst the day of choosing, grown fat on ideas in the hope that I will be a better person, a less lazy person, one halycon day.

Maybe for another day will be saved my explication of why, and who I want to be but more urgent concerns are intruding, food and the like, and while I’m sure you’ll appreciate my reaching out, you’ll also appreciate the cessation of that reach. Till tomorrow then.

–Afterthought–

A thing you might note about my diatribes is is that I am totally motivated by ideas: the real world (as you’d call it) seems to intrude little: that’s cos I too am to some extent an idealist: but not in the normal sense, in the sense that I believe the imeediate objects of our perception are


situation which remain and are as real as ever. The proposed implementation of the Tourism tax will not only create an administrative nightmare but will also have a negative commercial effect on the industry especially with those tourists coming over on prepaid packages. It will also have a negative effect on the host family sector, which has been included in the collection of this tax, to the detriment of the English Language Teaching sector.

The fact that the Court’s decision was based on a strict interpretation of the law which has resulted in the negation of the spirit of the Small Business Act will only make the Chamber even more convinced on the need to protect the right of meaningful consultation to ensure that the business sector, which underpinsthat takes a range as arguments, then you don't need to do the mod operation.  The function will probably handle any biases internally.

A:

C++11 has solve this problem by adding alternative random generator engines.
The reason why using %(modulo) to constrain your random number to a range is bad has less to do with bias and more to do with the typical implementation of rand(), a linear congruential generator (LCG). Most language runtimes use LCGs for their random function; only very recently designed languages tend to differ.
An LCG is just a multiply and an add (the modulo usually being implemented via an integer’s maximum size). It should be obvious that the low bits of such a sequence follow a regular pattern – the multiply doesn’t mix higher bits into


non-total pelvic floor reconstruction group (mean 9.8 months; P = 0.0003). The total pelvic floor reconstruction technique allows preservation of the blood supply to the urethra and physical reinforcement of the pelvic floor. Therefore, this technique is likely to improve urinary continence outcomes after laparoscopic radical prostatectomy.95% CI, 0.5 to 0.9). Drinking habits were associated only with deaths from ischemic stroke, and the risk patterns were different for men and women. In analyses, ex-drinkers should not be included with lifelong abstainers, since the former tend to run high health risk.


tin as Thailand’s leading exports. With the end of the Indochina wars and the insurgency, tourism developed rapidly and became a major earner. The urban population continued to grow rapidly, but overall population growth began to decline, leading to a rise in living standards even in rural areas, although the Isaan continued to lag behind. While Thailand did not grow as fast as the "Four Asian Tigers," (namely Taiwan, South Korea, Hong Kong and Singapore) it achieved sustained growth.

Prem held office for eight years, surviving two more general elections in 1983 and 1986, and remained personally popular, but the revival of democratic politics led to a demand for a more adventurous leader. In 1988 fresh elections brought former General Chatichai Choonhavan to power. Prem rejected the invitation offeredlarger popular mandate (40%) than any Thai prime minister has ever had in a freely elected National Assembly.

See also
History of Thailand (1932–73)
History of Thailand since 2001

References

External links

Bangkok Post.com (opinion section): "Memories are the first victim of happiness"

 1973
 1973
 History
 History
 History
 History


P.2d 460; Breshears v. Wright, 180 Okla. 553, 71 P.2d 455.
Finally complaint is made over the refusal to give requested instruction No. 2. The matters covered in this requested *419 instruction were submitted to the jury under the instructions given and as stated in Breshears v. Wright, supra:
"Where the instructions given reasonably state the law applicable to the case, this court will not reverse the cause for a refusal to give a particular instruction requested by the plaintiff in error."
Affirmed.
HALLEY, V.C.J., and WELCH, CORN, GIBSON, DAVISON, JOHNSON, and O'NEAL, JJ., concur.
since their introduction in the early ’80s, the C-Max returns the concept back to more compact dimensions, Ford said.

For example, the C-Max is about two feet shorter than popular competitors such as Honda Motor’s (HMC) Odyssey and Chrysler Group’s Dodge Grand Caravan.

The C-Max will go on sale in North America “by 2012.” The new model is based on Ford’s Focus compact car, a new version of which begins production early next month at Ford’s Michigan Assembly plant in suburban Detroit. Ford plans to build 10 models based on the basic structure of the Focus.

The C-Max will be priced between the Focus sedan, which starts at $16,640, and the Edge crossover, which starts at $27,220, Bloomberg News reported.

Ford may sell as many as 50,000 C-Max models annually in the


Browse:

When those 3 words are spoken, what comes to mind? Something you’ve been waiting to discuss? Something that you’d rather leave as the “elephant in the room”? Or something that you’ll address if and when the opportunity presents itself?

Long Term Care Planning isn’t for everyone—but Long Term Care Education is. To truly evaluate if this care makes sense for you, consider talking to or engaging with a Long Term Care Specialist that is:

Neutral in terms of the solutions that they provide

Education-focused, not sales-focused

And most important: Interested in building a relationship with you

Simply having a conversation can improve your outlook on Long Term Care planning and put you in the necessary mindset to prepare for the future. Even if you’re not ready to start planning now, education is keycame off, GAO added two new areas: federal financial risks due to climate change and reducing the gaps in weather satellite data.

Little change over two years

In all, GAO placed 30 programs across six major programmatic areas on its High Risk list. The number of programs remained the same as in 2011, with the two additions and two subtractions.

“Throughout the past decades, attention to high risk areas has brought results,” Comptroller General Gene Dodaro wrote in a letter to Sens. Tom Carper (D-Del.) and Tom Coburn (R-Okla.), chairman and ranking member of the Homeland Security and Governmental Affairs Committee, respectively, and Reps. Darrell Issa (R-Calif.) and Elijah Cummings (D-Md.), chairman and ranking member of the Oversight and Government Reform Committee. “More than one-third of the areas previously designated as


wild cards? What happens if you just run:

Code:

aptitude search java

You should get a list of all the java packages.

Quote:

Originally Posted by doru

I believe that aptitude should also be a front-end for apt-get. I believe that apt-get and aptitude should work together well...

Aptitude is not a front end for apt-get. They are similar, but they do handle dependencies slightly differently. I don't see any reason to use both apt-get and aptitude for installing and removing packages. On the other hand, I have experimented in Debian with both apt-get and aptitude to see how each command handles installing and removing packages. I never had a problem switching between apt-get and aptitude. If you hang out in the Debian forums, you will find that many long time Debian users use apt-get;my representative Oktar Babuna was treated most undemocratically when he tried to speak about the invalidity of Darwinism at a conference held by the Vatican's Pontifical Council for Culture; indeed, he was not even allowed to mention the fact that science had totally discredited the theory.

What the pope and the representatives of the Vatican must do is to remember God's might and sublimity, to abandon those views that directly conflict with faith in God and religion and to cease propagandizing evolution.

As the world looks for solutions to current social disasters, the Vatican must renounce a theory that lays the foundation for all irreligious ideologies that lead to persecution and irreligion and must cease blindly adhering to a scientific fraud.

People who are unable to appreciate the might of God


referrals for surgery.

The Corrections Department has historically not paid the costs when transgender inmates have requested sex-reassignment surgery, Scaletta said, defining it as elective surgery to be covered at the offender's expense.

Gov. Terry Branstad declined to say Monday whether he would support the use of state funds for gender-reassignment surgery for transgender Iowa prisoners.

“This is the first time that question has ever come up,” Branstad told reporters at his weekly news briefing at the Capitol. “I would certainly want to consult with the Department of Corrections with regards to this and also find out what the cost would be. … I think that is something that is a huge public policy issue that the state has previously not addressed.”

Donna Red Wing, executive director of One Iowa, the state’slargest organization advocating for gay, lesbian and transgender people, said California has considered the issue of transgender prisoners very seriously. She described the California requirements as “especially rigorous.”

“I believe that as there is more understanding and acceptance of transgender persons and issues, as gender dysphoria diagnosis is understood, gender reassignment surgery will be covered by health insurance policies and eventually included in the procedures available in our prisons,” Red Wing said.

She added, “There will be much more discussion. California leads the way. It will, I hope, be followed by the rest of the nation.”

The eight-page California policy calls for inmates who request the surgery and meet the criteria to be referred for evaluation to a committee of two doctors, two psychiatrists and two psychologists that would make a


pretend he's only about plain boxes.

To quote Loos approximately: the potter sits in anticipation in front of the kiln, waiting to finally see what beautiful colors God, in his infinite wisdom, left for Man to create. Loos loved color - and a plane of fabulously veined marble is one of the most decadent surfaces we have the pleasure of enjoying.

Nicely put Donna. My guess is Loos's own dogma of anti-ornament and the belittlement of sensual beauty precludes the ability to pivot as needed. Unfotrunatly, this general disdain for decoration, be it interior or exterior, is our modernist inheritance, even though it flies in the face of what we all do with our own personal spaces, ie. express ourselves.

Unfortunatley, Loos and many of his contemporary's schizophrenic relationship to beautyis a legacy that still hangs over the profession like dead weight. I'd attribute it to the moralising on beauty that began in ernest with Ruskin and eventually morphed into an almost nihilistic view of what was permisable in the brave new world we where promised.

I can only speak from my own experience that in Arch History in undergrad (four semesters which were great in pretty much every other way) all we were taught of Loos was "Ornament is A Crime" and "here are a bunch of plain white stucco boxes he built". I never knew of his interiors until I went to Prague and saw Villa Muller. He was a hedonist! He's been totally mis-represented and lumped in with the Bauhaus, in my opinion, because his exteriors


driving and control device 12 and the light-emitting source 13 can be disposed in a light body 14.
The switch element 11 is coupled to a power source 9, e.g. mains electricity, and the bridge current rectifying unit 121. The bridge current rectifying unit 121 converts the alternating current into direct current. The counting and control unit 123 is electrically connected to the bridge current rectifying unit 121, the driving circuit 122 and the light-emitting source 13, counting a switching number of the switch element 11, which is turned on for receiving the direct current from the light-emitting source 13, and outputting an enable signal accordingly. The driving circuit 122 drives the first LED unit 131 to emit the light of the first color temperature and/or drives the secondlike Pajo could pull off. The second is the sloppy verse part, which makes what could be the theme music for a strutting street walker. At its culmination, McMahan hollered the words like he was doing his best Henry Rollins impersonation as Pajo offered up a Frank Zappa-esque squiggly solo.

Mimicry (even self-mimicry) aside, it was the highlights of "Spiderland" that were the most impressive recreations. As on record, "Washer" was a circular cascade of guitar and bass notes that strayed from their original pattern for a brooding, sometimes visceral digression before revisiting the core concept. For the bluesy dirge "Don, Aman," Walford climbed from behind the drumkit, sat on a chair at the lip of the stage and strummed a guitar across from Pajo. As Walford grumbled the


SLC11A1, MSR1, CD64CLL, AMLmiR-15521q21.3OGAGTR1, FGF7, ZNF537, ZIC3, IKBKECLL, AML (FLT-IDT+), HL, NHL (BL, ABC-DLBCL)miR-17-92 cluster13q31.3OG/TSGE2F1, PTEN, BIMCML, ALL, HL, NHL (B cell lymphomas)miR-20314q32.33TSGABL1CMLmiR-128a (miR-128-1)2q21.3OG/TSGN/AHigh in ALL vs. AML; low in HL EBV+miR-128b (miR-128-2)3p22.3OG/TSGN/AHigh in ALL vs. AML; low in HL EBV+let-7b22q13.31OG/TSGRASHigh in AML vs. ALLmiR-223Xq12OGN/AHigh in AML vs. ALLmiR-2049q21.11TSGHOXA10, MEIS1AML (NPM1 mut)miR-34b11q23.1TSGCREBAMLmiR-91q22 (miR-9-1)\
5q14.3 (miR-9-2)\
15q26.1 (miR-9-3)OGPRDM1/Blimp-1HLlet-7a9q22.32 (let-7a-1)\
11q24.1 (let-7a-2)\
22q13.31 (let-7a-3)OG/TSGRAS, PRDM1/Blimp-1HLmiR-967q32.2TSGN/ALow in HL EBV+miR-2117q23.1OGPTEN, PDCD4HL, NHL (ABC-DLBCL)miR-249q22.32 (miR-24-1)\
19p13.12 (miR-24.2)OGN/AHLmiR-15019q13.33TSGN/AHLmiR-221Xp11.3OGN/ANHL (ABC-DLBCL)miR-1435q33.1TSGERK5NHL (B-cell lymphomas)miR-1455q33.1TSGERK5NHL (B-cell lymphomas)[^2]

miRNAs and leukemias {#S2}
====================

Leukemia is a malignant disorder of the blood or bone marrow characterized by an abnormal proliferation of blood cells. Based on the stage of differentiation of the malignant cells, leukemias can be divided into acute and chronic. Acute leukemias are characterized by the rapid increase of immature blood cells (blood cell progenitors or primitivecounterparts, the majority of cells in primary HL cases showed weak or no PRDM1/Blimp-1 expression.^[@R45]^ Navarro *et al.*, analyzed the expression of miRNAs in 49 HL patients and 10 reactive lymph nodes. They identified 25 miRNAs discriminating HL from reactive lymph nodes and 36 miRNAs differentially expressed the nodular sclerosis and mixed cellularity subtype.^[@R46]^ The obtained results, validated in a set of different cell lines, showed that miR-96, miR-128a, and miR-128b were selectively down-regulated in HL with EBV. Moreover, only one of the miRNAs differentially expressed in EBV^+^ cases was enclosed in the 25 miRNA that distinguish HL from reactive lymph nodes, leading to the intriguing conclusion that EBV might not be a relevant event in HL pathogenesis.^[@R46]^ Gibcus *el al.* described a specific miRNA expression profile in


miRNA aberrant expression. For several hematologic malignancies, a clear diagnostic and prognostic role of miRNA de-regulation has been demonstrated. The identification of miRNA targeted mRNAs is clarifying which oncogenic pathways are affected by the leukemic/lymphomatous miRNome. This knowledge represents the essential background to the development of new miRNA-based therapeutic approaches, which combine the advantage of a *physiologic* molecule (such as an miRNA-derived drug), to the possibility of targeting with a single molecule several members of the same and/or of several aberrantly activated pathways in the malignancy. More studies are warranted to define how big is the impact of these tiny RNA molecules in human cancerogenesis. However, there is no doubt that these ncRNAs play a role in hematologic malignancies. Decoding this role has diagnostic, prognostic and therapeutic implicationspackage us.nineworlds.serenity.core.imageloader;

import android.content.SharedPreferences;
import android.graphics.Bitmap;
import android.graphics.drawable.BitmapDrawable;
import android.graphics.drawable.Drawable;
import android.graphics.drawable.TransitionDrawable;
import android.preference.PreferenceManager;
import android.view.View;

/**
 * A runnable that transitions between a drawable and a bitmap.
 *

 * It supports not doing transitions when the bitmaps are the same.
 *

 * It currently depends on setting transitions at all if there is a fade in
 * transition preference enabled in the app. Remove that section of code if you
 * don't need this support.
 *

 * If transition support isn't enabled then it doesn't do transitions and just
 * sets the bitmap as the background to the view passed in the constructor.
 *

 * Code licensed under an MIT license so do what you want just give attribution
 * where it was obtained.
 *
 * @author davidcarver
 */

public class BackgroundBitmapDisplayer


nice way of getting people... interested in that idea all over again." "This was kind of a very far-fetched idea... that wasn't even considered very seriously by many physicists... until Carl Sagan decided to write this book... and try to make it as realistic as possible." "And since that time, theoretical physicists... studying Einstein's general theory of relativity... have considered travel through wormholes." "Scientists began to investigate... whether there might be a type ofwormhole... different from Einstein's that is traversable." "But traversable wormholes needed something... to prevent them from pinching off." "You want to stabilize the wormhole." "You don't want the wormhole to collapse." "¤eep the wormhole open." "That requires something new called negative matter or exotic matter." "We've never seen negative matter before." "It would have anti-gravitationalproperties." "But one day, ifwe ever find negative matter... perhaps that's the key to stabilize the wormhole." "The idea of a traversable wormhole... captivated science fiction enthusiasts." "It also reinvigorated the serious study ofwormholes... within the science community." "This transversable wormhole created quite a sensation... 'cause perhaps it is physically possible... to one day build a subway system to another galaxy." "The term wormhole came from an analogy with an apple." "You want to get from one part ofthe apple to another part." "Ifyou're a worm... you can eat yourway down into the body of the apple... and make a little tunnel and come out the otherway... and it's shorter." "But unlike a worm moving here on this apple... for a wormhole in our universe... we might not


time machine or a wormhole machine... that would take us to a distant galaxy... you would have to have the physics... of an advanced civilization... a civilization perhaps millions ofyears beyond ours." "Time machines have mystified movie audiences for overfifty years." "Gentlemen, I am talking about traveling through time... in a machine constructed for that very purpose." "But could a wormhole be used for such travel?" "The wormhole may lead to things... like being able to go to another galaxy... bywalking five feet through a wormhole... or even going to another time." "But wormholes as time machines pose unsettling questions." "In the distant future, will earthlings be able to travel to the past... and perhaps change history?" "Scientific ideas considered far-fetched today... could one day become as acceptable...hole collisions... were impossible to identify." "Now scientists have developed gravitational wave detectors... to track these vibrations... and hopefully catch black hole collisions in the act." "LlGO is a ground-based observatory... that's currently searching... for gravitywaves produced from collisions... involving stellar-sized black holes... a few times the mass of our Sun." "The system uses lasers to measure the motions of mirrors... that hang by wires from overhead supports." "When two black holes merge together... they'll release these gravitational waves... these ripples in the shape of space." "And as the ripples pass by these giant contraptions... they alter ever so slightly... the distances between these detectors... and the detectors can actually monitor... and see that change in distance... and that's the signature of a gravitational wave coming by." "In


aren't completely inert objects... that only suck things in and nothing comes out." "They actually radiate." "The black holes that radiate are called mini black holes... which are much smaller than their stellar mass... or supermassive black hole cousins." "Celebrated physicist Stephen Hawking proposed... that if mini black holes exist, they must emit radiation... which has been named Hawking radiation." "It is believed this radiation... will cause a tiny black hole to evaporate... and potentially disappear." "Hawking gave mathematical evidence... that when a tiny black hole forms and then evaporates... some of the information that went into the black hole... never comes back out." "This startling prediction caused a firestorm among physicists... because the laws of quantum theory... insist that information can never be completely destro¤ed." "Essentially, thebut they could give several important clues... about whether information comes back out... ofthe mini black hole and even how the universe began." "They do provide a laboratory... to see howfarwe can push Einstein's theory... until all hell breaks loose and the equations collapse." "And that's why we think that mini black holes... could be a key to going beyond Einstein." "Physicists will continue to probe into the mysteries... still surrounding black holes." "They will also remain on high alert... for any signs ofthe elusive wormholes and white holes." "The search for the next frontier marches on." "White holes, wormholes, black holes... are tickets to oblivion for the most part." "None of these are places... that you want to take your summervacation near... and these tickets will cost


{
        this.description = d;
    }

    @GET
    @Path("products/{productId}/")
    public Product getProduct(@PathParam("productId") int productId) {
        Product p = products.get(Long.valueOf(productId));
        return p;
    }

    final void init() {
        Product p = new Product();
        p.setId(323);
        p.setDescription("product 323");
        products.put(p.getId(), p);
    }

}
Series' first use of a three-cylinder engine in its 2015 facelift. A new plug-in hybrid F30 model was also introduced in 2016. A long-wheelbase sedan version (model code F35) was sold in China.

The M3 model (designated F80) was introduced in 2014 and is powered by the S55 twin-turbocharged straight-six engine.

In March 2019, the BMW 3 Series (G20) began production as the successor to the F30.

Development and launch
The exterior designer for the F30 sedan was Christopher Weil and exterior designer for the F31 Touring was Michael de Bono.

The F30 was unveiled in Munich on 14 October 2011 and the launch event was held on 11 February 2012.

Body styles

Sedan (F30)
The F30 sedan debuted at the 2012 Geneva Motor Show in March 2012 and was the first of


comprising 9 training units, 60 min each, at 60--70% of HR~max~, tempo 140--152 bpm, (iii) 3 weeks including 9 training units, 60 min with an intensity of 65−75% of HR~max~, tempo 145--158 bpm, and (iv) 3 weeks comprising 9 training units, 60 min with an intensity of 65%−80% of HR~max~, tempo 145--160 bpm. All 36 training units were administered and supervised by the same instructor.

Body Composition Measurements {#j_hukin-2016-0055_s_002_s_004}
-----------------------------

All participants were measured for selected body mass and body composition variables before and after the completion of a 12-week training period, which had been shown appropriate to observe changes in body composition ([@j_hukin-2016-0055_ref_023]; [@j_hukin-2016-0055_ref_025]). Body mass and body composition were assessed by bioimpedance analysis (body's inherent resistance to the electrical current) with the use of an electronic scale (Tanita TBFmaximal peak respiratory minute volume (VE~max~), before and after the completion of a 12-week training period. The device was calibrated in accordance with the manufacturer's instructions. A previously implemented protocol was used to determine VO~2max~ ([@j_hukin-2016-0055_ref_042]). The test began by 5 min continuous pedaling, with a frequency of 60 revolutions per minute (RPM) and a relative load of 1.2 W/kg. After this phase, the workload was systematically increased by 15 watts every minute until voluntary exhaustion. The effort was interrupted when pedaling frequency declined by 10%, that is, when the pedalling frequency fell below 54 RPM. All of the participants reached RER greater than 1.0. The highest values of oxygen uptake, heart rate, minute ventilation and power output maintained for 15 s were considered to be VO~2max~, HR~max~,


      7.73 ± 0.74   7.66 ± 0.81   7.74 ± 0.75   *p* = 0.808           *p* = 0.021     *p* = 0.718
  W~tot~ (J/kg)   178 ± 18          186 ± 15      181 ± 18      191 ± 18      *p* = 0.147           *p* \< 0.0001   *p* = 0.311

Values of the variables of both groups before and after training are means (± SD); P~max~ -- maximal power; W~tot~ -- total workcompared to AA homozygotes, regardless of changes in body mass. The lack of significant changes of HRAT/HRmax in the group CC+AC also suggests that the examined group reacted more to the training loads obtaining energy from anaerobic sources which resulted in non-significant changes expressed in percentages.

The AA genotype group obtained the energy needed to perform the same effort from aerobic transformation to a greater extent than the CC+AC genotype group, which caused the anaerobic threshold shift for the HR in the direction of higher values, while reducing the maximum heart rate. A significant increase in VO2max, while reducing the maximum heart rate and an increase of HRAT/HRmax is a common physiological response to loads such as aerobic energy transformation carried out at and below the anaerobic threshold. Furthermore,


We use cookies to customise content for your subscription and for analytics.If you continue to browse Lexology, we will assume that you are happy to receive all our cookies. For further information please read our Cookie Policy.

Personal smartphones: a ticking HIPAA/HITECH time bomb?

In this brave new world of health information privacy, many industry experts and healthcare organizations have emphasized the need to secure portable electronic devices such as laptops, issued to employees. But a recently published survey conducted by Cisco mConcierge appears to indicate that personal smartphones, increasingly used by employees for work purposes as part of "Bring Your Own Device" (BYOD) programs, may present a more significant privacy threat than previously thought.

According to the survey, 89 percent of healthcare workers use their personal smartphones for work purposesAFP reported that Egypt called on Arab League members to enforce a counterterrorism treaty that would block funding and support for the Muslim Brotherhood.

Cairo also wants the League’s members to hand over wanted Islamists linked to the Brotherhood, to which deposed president Mohammed Morsi belongs, the report said.

Egyptian foreign ministry spokesman Badr Abdelatty said that Arab League members that signed the 1998 counterterrorism treaty should enforce it against the Brotherhood.

The treaty coordinates anti-terrorism measures between signatories.

“The signatories are responsible for implementing the treaty,” Abdelatty told AFP, adding that members would have to stop financing the group and hand over Brotherhood fugitives to Egypt.

An Arab League official told the news agency that 18 of the Arab League’s 22 members had ratified the treaty.

Egypt’s designation of the Muslim Brotherhood as


- 2) + -8 + 12 + (0 - 4)?
-4
Evaluate -4 + 2 + 21 + (-11 - -29).
37
-54 + 59 + (1 - 1) + 6 - 6
5
What is the value of -10 + 6 + -11 + 12?
-3
Evaluate 11 + 8 + -19 + (50 - 31).
19
Evaluate (-1 - -2) + -5 - (14 - 8 - 1).
-9
Evaluate -9 - ((9 + -1 - 13) + 1).
-5
What is (2 - 3) + -1 - (9 + (8 - 5))?
-14
Calculate 0 + 0 + 16 + 0 - (3598 + -3592).
10
What is the value of -1 + (8 - (-22 + 11 - 1))?
19
228 + -221 - (2 + -6)
11
What is the value of (2 + 5 - 3) + (-15 - -13)?
2
What is 0 - (-2-5 + -58 + 98.
25
Calculate -11 - -17 - 16 - 10.
-20
78 - 66 - (-2 - -7 - 0)
7
Evaluate -25 - ((15 - 21) + -11).
-8
-24 + 1 + 118 + -104
-9
Evaluate -12 + 1 + (5 - -5).
-1
What is -19 + 1 + 22 + -13?
-9
32 + 4 - (163 - 143)
16
27 - 37 - (-13 + 1)
2
What is -29 - (21 - (-23 - -76))?
3
Evaluate -51 + 45 - (8 + -41).
27
28 + -27 + -33 + 29
-3
-2 + 2 + -10 + 7
-3
Evaluate -5 + -6 - (17 + -6 + 3 + -9).
-16
What is the value of 9 + -2 - (25 + -35 + 10 + 2)?
5
Evaluate 1 + 12 + (-44 - (-15 + 3)).
-19
What is 1 - (26 + -2


  }
    }
}

A:

Try changing this:
TextView textView = new TextView(this);
setContentView(textView);

to this:
ScrollView sv = new ScrollView(this);
TextView textView = new TextView(this);
sv.addView(textView);
setContentView(sv);

mean those projects are any good, or worth your time. If you have savings to fall back on, you'll know where your next meal is going to come from, and you can be more selective in the jobs you take (even the well-paying ones). If you have decided that taking low-to-no paying work is acceptable to you, then it would be best to develop criteria that will help you decide if the project is a good fit.

Periodically, I will take on low-to-no paying work if it falls within the criteria that I have decided on. For example, some of the questions I ask myself are: Will I be working with people I enjoy working with? Am I interested in the project/does it excite me? Will I get the


something, follow through on that commitment no matter what. If you do good work, and give it your all, you will get noticed, and people will want to work with you.

Tip #3: Network, Network, Network...

It is all about numbers. The more people you know, and the more people who know you and what you do, the bigger your referral stream, and the more potential you have for work. So get out there and develop relationships with people in the industry and film community who could be sources of referrals. I have had referrals from PA's, actors, editors, other cinematographers -- you never know where your next job might come from.

I admit that this is not something that I am naturally good at, or inclined to do. This meansof Redfern All Blacks. All players that have the ability to kill it in the NRL, but for their own reasons were not fortunate enough to do so… yet.

It’s been often said that the crowd swells whenever the women’s games are played on the main field. They just love to play the knockouts as much as the men, and in some cases more. Lavina Phillips-O’Mealey of Redfern has been my favourite to watch over the years, and Redfern’s battles with Mindaribba in recent years have been an annual highlight. The women play without fear, have seriously silky skills, and the will to win required at these knockout carnivals.

Prior to the first event in 1971, a group of very strong and proud Aboriginal men had the vision to create


 dispatched on a Medicaid run. There are specific procedures in place for such

      transportation. Medicaid runs are arranged in advance with a pre-designated

      pickup and drop off location. Paperwork is sent to the taxi company ahead of

      time and the run is dispatched to a driver. The driver receives the person’s

      name and telephone number and maintains paperwork which the passenger

      must sign as confirmation of the ride. The driver must take the shortest route

      possible and any changes in the destination must have Medicaid authorization

      before the driver can take the to Downing, learned the procedure pertaining to Medicaid rides, and

       discovered that Scott had been picked up under an assumed name. The officer

       also learned that Fashir had picked up Scott at Rally’s, not a medical facility,

       and brought him to the CVS.

[10]   Officer Shirey asked Scott to explain the situation, but Scott did not. Scott was

       arrested and handcuffed. He then reached into his pockets, pulled out some

       money, which was not enough to cover the fare, and yelled and screamed that

       he would pay for the ride.

[11]


variation of pubertal onset is not genetically-dependent ([@B31]), it is obvious that there should be other key players that actively participate in its regulation. Data obtained from elegant studies have shown that several extrinsic factors participate in the orchestration of the pubertal process.

Epigenetics {#s7}
===========

Epigenetics are involved in almost every function of the developing organism including puberty. The term epigenetics refers to any modification of gene expression, which cannot be attributed to changes of DNA sequence itself. Epigenetic modifications include DNA methylation, chromatin packaging, non-coding RNAs, non-coding DNA regulatory sequences, and long-range transcriptional regulators (enhancers and insulators) ([@B32]). The existence of the childhood neurobiological "brake" that represses the onset of puberty is well-documented. Since DNA hypermethylation of gene promoters is associated with gene silencing, a role for epigenetics inhumans are exposed to one or more EDCs at different levels and time periods, an apparent role of EDCs in the above changes could certainly be postulated ([@B45]).

Adipose Tissue {#s9}
==============

The existence of a direct relation between pre-adolescent weight gain and the age of pubertal onset was noted several decades ago. The increasing global childhood obesity epidemic has been implicated as a cause of a lower age of pubertal onset among the contemporary population. Data originating from prospective studies demonstrated that an excessive increase in BMI during the childhood years led to earlier puberty development ([@B46]). Furthermore, data from GWAS have shown that the BMI-increasing allele of several genetic loci was associated with earlier age at menarche ([@B47]). Indeed, according to the "somatometer hypothesis," a certain amount of fat


several key components regulate energy and nutrient sensing and the equilibrium between anabolic and catabolic signals. These include the mammalian target of rapamycin (mTOR) pathway, which is the main cellular nutrient sensor (which senses availability of glucose and amino acids) and controls protein and lipid biosynthesis, and the AMP kinase (AMPK) pathway, which is the main energy sensor (which senses AMP vs. ATP levels). The latter is stimulated by oxidative stress and controls mTOR The mTOR sensor pathway can be activated by glucose, amino acids, and hormonal signals (IGF-1, insulin) and can influence downstream effects on protein translation and cell growth ([@B78]). The available evidence suggests that suboptimal activity of components of the above pathways can cause failure to recognize abnormal nutrient/fuel levels, leading to maladaptive cellular responses,system along with our open borders. Those alone are really the only things that allow the problem to be in existence. Honestly the only people doing anything to combat ISIS are the Kurds and Russians. When it comes to America's fight all I see us doing is simply taking out ISIS leadership and not ISIS as a whole. We will never see an end to ISIS if the Obama team continues to think that taking out only ISIS leaders is somehow a victory in this fight. Our lack of proper vetting of our visa program alone is what made the San Bernardino shooters commit their act. The main problems in this fight is paperwork, vetting, and our unprotected borders. If we fixed all those issues we could possibly


Son of Chinese government official drugged and sexually assaulted girl at British university after spending months downloading date rape pornography

Xuanyu Zhong, 25, was obsessed with brutal date rape pornography

He spent months researching on internet how to carry out his 'fantasy'

Northumbria University student drugged victim before assaulting her

Was jailed for six years at Newcastle Crown Court for sexual assault

Jailed: Student Xuanyu Zhong, 25, drugged and sexually assaulted his female victim after becoming obsessed with date rape pornography

A university student obsessed with date rape pornography turned his fantasy into reality by drugging and sexually assaulting a woman.

Xuanyu Zhong, the son of a Chinese government official, committed the crime after watching hours of sick rape videos on the internet.

The Northumbria University student researched date-rape drugs, bought some online and carried outthose delicious home made goodies. A real treat.
I love coming along and really treasure my time with you. There is always some help when you get stuck or want to learn and always something to inspire you.
I don’t get there as often as I would like but hopefully restraints on my time will become less. I can’t wait for my next Escape!

Meet Gillian

Hello my name is Gillian and thank you for visiting me at Escape to the Crochet here in beautiful Northumberland.

David and I run our cosy little B&B here on our smallholding and especially love to welcome guests to our crochet day retreats and short breaks where it’s all about colourful crochet, homemade cakes and good home cooking.

Crochet gives me an escape that I love and I


has become part of the daily life in Ypres and traffic is stopped from passing through the memorial. Only during the Second World War was the ceremony interrupted.

For all of you looking for a guided battlefield tour, do pick one that includes this beautiful city and allow Rifleman Tours the opportunity to bring history back to life.streets of the ancient city of Lindon. A crossroads place between the Iron Mountain of the northwest and the growing deserts of the east of Eriduah after the shambles of the Great War of the Ring of power. Thirty years before the Great Departure of elvendom from Middle-Earth, the population of Lindon began to change with the arrival of he settling Bedouin people. Leaving their tents behind for brick homes. The city showed its own sets of challenges to overcome for the likes of Joleeth.

Shimzabar stowed away on a hip he invested all his hopes in that would lead him out and beyond The Great Sea. However as it made sight of Mithar's harbor the boy was discovered, badly beaten, and thrown overboard. The laughing fisherman shock their


appeal the award:
        Since an attorneys’ fee award is considered part of the costs of litigation . . . the
        award goes straight from the plaintiff to counsel and is not intended to serve as
        additional compensation for plaintiffs. This means that ‘the question whether the
        motion for fees is in the name of the party or his attorney is a technicality,’ because
        ‘it would exalt form over substance to deny the motion for fees’ if an attorney, and
        not the plaintiff, is the named party.
Mathur,317 F.3d at 741 (quoting Lawrence v. Hacker, 966 F.2d 1153 (7th Cir. 1992) (emphasis
added). The Fifth Circuit addressed a similar question in Lipscomb v. Wise, 643 F.2d 319 (5th Cir.
1981). There, several attorneys involved in a class action lawsuit appealed a lower court ruling
denying them standing to seek attorneys’ fees. The Fifth Circuit found that the attorneys did have
standing because they had alleged a “personal stake in the outcome” and would potentially “suffer
an economic injury in fact.” Lipscomb, 643 F.2d at 320 (denying the request for attorneys’ fees on
other grounds).
        The Federal Circuit reached a different result in Willis v. Government Accountability Office,
where, again, an attorney – and not the “prevailing party” (i.e., plaintiff) – appealed a GAO decision
denying additional


be “reasonable.” Reed
v. Rhodes, 179 F.3d 453, 471 (6th Cir. 1999) (citing Blum v. Stenson, 465 U.S. 886, 893 (1984)).
A reasonable fee is “adequately compensatory to attract competent counsel yet which avoids
producing a windfall for lawyers.” Geier, 372 F.3d at 791 (emphasis added); see also Coulter v.
Tennessee, 805 F.2d 146, 149 (6th Cir. 1986) (“[H]ourly rates for fee awards should not exceed the
market rates necessary to encourage competent lawyers to undertake the representation in
question.”). The starting point for determining a reasonable fee is the lodestar, which is the product
of the number of hours billed and a reasonable hourly rate. See Hensley v. Eckerhart, 461 U.S. 424,
434 (1983). The district 2court’s calculation of the lodestar value, as well as any justifiable upward
or downward departures, deserves substantial deference, but only(5th Cir. 1974).
Nos. 06-4184/4256/4266                   Gonter, et al. v. Hunt Valve Co., et al.                             Page 6

by using 2004 rates instead of the current, 2005 billing rates. And third, the Plaintiff argues that the
2004 rates used by the district court were unsubstantiated and thus based on clearly erroneous
findings of fact.
         To justify any award of attorneys’ fees, the party seeking compensation bears the burden of
documenting its work. Reed, 179 F.3d at 472 (citing Webb v. County


(noting that current rates were appropriate to counterbalance a delay in payment)
(reversed on other grounds). But Barnes does not stand for the proposition that this Court mandates
– or even prefers – application of current rates; rather, as the Barnes Court itself stated, the
application of current rates was “within the contemplation of the attorneys fees statute.” 401 F.3d
at 745; see also Louisville Black Police Officers Organization, Inc. v. Louisville, 700 F.2d 268, 278
(6th Cir. 1983) (“[W]e reiterate today that the district courts retain their discretion in such matters
constrained only by their duty to achieve the goal enunciated in Northcross: to make an award of
fees which is ‘adequate to attract competent counsel, but which does not produce windfalls to
attorneys.’”) (citing Northcross, 611 F.2d at 633). Accordingly, the district court hasmillion
settlement with the Shipbuilders comprised over fifty percent of the yearly total for FCA actions
where the Department of Justice did not intervene. While the district court noted that $12.5 million
was a “substantial sum,” it also observed that the Relators had sought $100 million in compensation
and, more importantly, that Morgan and Verkamp – the attorneys most involved in the settlement
– had not sought an enhancement. Consequently, the district court refused to apply an enhancement.
        The considerable sum earned in the settlement does represent an important vindication of
the goals underpinning the FCA. But the facts of this case – including, as the district court observed,
Volkema’s more obvious role in the outcome – are distinguishable from examples where courts have
found “exceptional success.” See, e.g.,


was accompanied by elevated levels of intracellular, non-glycosylated E2 protein. However, the levels of intracellular glycosylated forms of E2 and of extracellular E2 were similar for both type of terminators. These results show that translation of the recombinant mRNA is not the rate limiting step in the expression of glycoproteins, but the downstream processing and secretion of the translation products.-The Lead: The Clark University baseball team picked up their second win of the season in their first game on Friday morning over the Mariners of Mitchell College. The

HOW IT HAPPENED

-After a 1,2,3 top of the first inning, junior Andrew Thibault (Nashua, N.H.) led off with a single up the middle for Clark. Junior Derek Lefebvre (Groton, Mass.) sent a homer over the left field fence to put two runs on the board for the early 2-0 lead.

-Junior Collin Porter (Brookfield, Conn.) started things off in the bottom of the second with a lead-off single that snuck up the left field line. First year Andrea Casabianca (Yonkers, N.Y.) sent a hard hit ball up the middle that was stopped by the diving second baseman, but he was unable


depth to what is currently available to researchers, providing endless potential for analysis and new understanding of how the health insurance market is evolving," said Katherine Hempstead, senior adviser at the Robert Wood Johnson Foundation.

"Vericred shares the Robert Wood Johnson Foundation's goal of increased transparency across all sectors of healthcare," explains Michael Levin, Vericred's co-founder and CEO. "These datasets will enable researchers to investigate aspects of health insurance that would otherwise be impractical if not impossible to do. We look forward to seeing research results that come from this initiative."

Many analysts have already used these data, including government agencies, academic researchers, and analysts from the private sector. Just recently, University of Pennsylvania's Leonard Davis Institute for Health Economics performed a study using Vericred's network data to analyze the50 to 100 ml, shaped as a flat plate of max. 10 mm thickness. A sufficient gas exchange in this open headroom is possible only if the flushing is performed with quantities of protective gas amounting to several times the volume of the headroom. This procedure is thus unsatisfactory, already from the point of view of requirements for protective gas. An additional disadvantage of this process is that it is impossible to avoid infiltration of oxygen from the air in the headroom filled with the protective gas. After the flushing with the protective gas, it takes an additional time of approx. 2 seconds until the container is provided with a cover. This idle time causes renewal of the gas exchange, the oxygen content increases again. Furthermore, when the


Congress Just Buying People Cars Now - colins_pride
http://www.economist.com/blogs/freeexchange/2009/07/congress_just_buying_people_ca.cfm

======
jrockway
Can I have a $4500 voucher for a new bicycle? It uses no fossil fuel at all.
(I estimate that an 18-pound bike will cause me to consume one less banana per
week, compared to my current 21-pound bike. This will save hundreds of bananas
per decade.)

~~~
josefresco
I wasn't aware that banana consumption was a problem or that America depends
on a healthy bike industry to thrive. News to me!

~~~
jrockway
I wasn't aware that having a slightly-old car was a problem.

~~~
jzachary
It isn't a problem. You car is probably perfectly fine and may get great gas
mileage. The problem is that you are not consuming. Bad American!

------
andreyf
Cars? People still buy those things?

I wonder how much non-drivers' taxpayer money goes to subsidizing others'
choices of transportation like this...

~~~
jamiequint
Easy to say thatI agree with the Economist--
this program is really about getting people to buy new cars.

 _Cars? People still buy those things?_

Yes. Why not? They're a tool, just like everything else. My family really
enjoys traveling, so we (four of us) own one car. More often than not, it's
parked in front of our house. We walk, bike, and bus ourselves around when we
can. But it's also nice to be able to leave the city on the weekend and go
camping and climbing. Or visit family. Acting as if you are on a higher moral
plain because you can't comprehend why people still buy cars doesn't do much
to advance the conversation and convince people to rethink some of their
lifestyle choices.

That said, as I mentioned, I think this subsidy is a terrible idea.

~~~
jrockway
A car


know the lies they always told you ♪" "♪ The only love you never dreamed ♪" "♪ Was of things they never showed you ♪" "♪ That swallowed the light from the sun ♪" "♪ Inside your world ♪" "Oh, somebody's lost." "♪ Yeah ♪" "♪ I'm comin' down to a world turned over ♪" "♪ A dangerous fall without you there ♪" "♪ As I go on I will lead you homeward ♪" "♪ All because all ♪" "♪ I'll become ♪" "♪ You became to me ♪♪" "Sweet ride." "Who scored this?" "Probably some spoiled-ass mother–" "Shiverson!" "[ Boy ] Look at that chrome on that thing, man." "[ Boy #2 ] Very nice." "It's, uh, a very nice gift." "I'm sure you're disappointed." "Why, 'causeto come up with a better deal." "It's a matter– Yeah." "I gotta go." "Listen, I worked everything out with these people, including your meals." "So all you're gonna need is some spending money." "This should last you for a while, but if you need some more, you just call my office." "I'm gonna be a little hard to reach for the next few weeks." "Okay." "Hello there." "Good afternoon." "Hey." "I'm running a little late, and I have a flight to catch, so I assume there's nothing else we need to discuss." "No." "I think we're good." "Your room's right above the garage if you want to go up." "Now, you remember what I told you." "Keep your eyes forward on the important things." "Yes, sir." "That's


exactly?" "Listen, Richie." "You don't want to mess with me." "All right?" "Ooh." "Scary." "I'm surprised you even bother with a girlfriend, you got such a good thing with those cows." "What's that supposed to mean?" "Aw, come on." "You got yourself a regular harem out there." "Get your hands up their skirt every morning." "You serenade them every night." "That, or you're in love with a 600-pounder who likes to chew her vomit." "You know what I'm really doin' up there, Richie?" "What's that?" "Your mother." "What's your problem, man?" "Hey!" "Hey!" "Stop it!" "What's the matter with you?" "Come on." "Get up." "Let's go." "Let's go." "Hey, hey!" "You can quit right now." "Right now." "I quit." "You can't quit." "It isn't a job." "It's aused to calculate the solvent accessible surface area of the final model. Additionally, using the FoldX program (<http://foldx.embl.de/>) [@pone.0000378-Guerois1], in silico alanine-scanning was performed by mutating each residue and calculated the change of folding energy. Molecular surface visualization was done using Chimera (<http://www.cgl.ucsf.edu/chimera/>) [@pone.0000378-Sanner1], [@pone.0000378-Pettersen1]. The surface was color-coded according to the Poisson-Boltzmann potential calculated by the UHBD program [@pone.0000378-Davis1].

Mutation analysis, constructs, viral production and titration {#s2d}
-------------------------------------------------------------

The plasmid expressing a hemagglutinin (HA)-tagged form of APOBEC3G was a kind gift from M. Malim. A series of APOBEC3G alanine and specific mutants was constructed with the QuickChange Mutagenesis kit (Stratagene). The collection was already constituted, and it was not defined on the basis of the new structural data. HIV-1 particles were produced by transient transfection of 293T cells with Fugene


side chain packing is correct. In the latter case, docking simulations could be envisioned based on the current model. As recently shown for TRIM5α [@pone.0000378-Ohkura1], the model proposed may serve to guide further functional analysis of APOBEC3G.

Supporting Information {#s5}
======================

######

Panel A, Target-template alignment. Alpha helix are shown in red and beta sheets in green. The huAPOBEC3G N-CDA is aligned to the outer (O) monomer of APOBEC2, and the C-CDA to the middle (M) monomer. Panel B, ANOLEA scores. The three ANOLEA profiles and the secondary structure were aligned according to the target-template alignment. The ANOLEA profile excludes the uncharacterized linker (residues 195-214)

(2.86 MB EPS)

######

Click here for additional data file.

We thank X.S. Chen for APOBEC2 PDB data.

**Competing Interests:**The authors have declared that no competing interests exist.

**Funding:**Supported by Swissthe chamber 6a of the connector 6 from the upper side of this connector 6, the contact pads 4 and 5 of the camera module 1 are press-contacted respectively with the contact projections 9a and 10a of the connector pins 9 and 10 of the connector 6, as shown in FIG. 6.
Signals of the camera module 1 are transmitted to the contact pins 9 and 10 via the contact pads 4 and 5 and the contact projections 9a and 10a, and further are transmitted to a circuit (not shown) of the wiring board via the terminals 9b and 10b.
FIGS. 7A to 7D show a second related-art camera module 11. This camera module 11 comprises a module body 12, and a lens portion 13 formed on an upper


that the Firemen's Union, Railroad, and National Mediation Board are legally without authority to convene a special adjustment board to interpret and apply the Engineers' collective bargaining contract to these firemen-engineer disputes, and for an injunction against the exercise of the assumed subject matter jurisdiction. On a motion to dismiss, Judge Arraj first sustained his own jurisdiction to review, Brotherhood of R.R. Trainmen v. Denver & R.G.W.R., 370 F.2d 833 (10th Cir. 1966) cert. den. 386 U.S. 1018, 87 S.Ct. 1375, 18 L.Ed.2d 456 (1967), and cf. Garvey v. Freeman, 397 F.2d 600 (10th Cir. 1968), then confirmed subject matter jurisdiction of the special adjustment board. He accordingly dismissed the Engineers' Union's action for failure to state a claim for injunctive relief.

6
The Railroad and the N.M.B. chose totake no part in the appeal, leaving the Firemen's Union as the only answering Appellee. No question of judicial review is raised on appeal. But we should not exercise our injunctive powers to interfere with the establishment of the special board and the exercise of its jurisdiction unless it is made to appear that the invocation of the board was clearly unauthorized and that the exercise of subject matter jurisdiction would leave the Appellant without remedy. Transportation-Communication Emp. Union v. U. P. R. Co., 385 U.S. 157, 164, 87 S.Ct. 369, 17 L.Ed.2d 264 (1966); Whitehouse v. Illinois Cent. R. Co., 349 U.S. 366, 75 S.Ct. 845, 99 L.Ed. 1155 (1955), and cf. Myers v. Bethlehem Shipbuilding Corp., 303 U.S. 41, 51, 58 S.Ct. 459, 82 L.Ed. 638


cannot have a pointer from one process to another. Their memory is separated and one process cannot usually see the memory of another memory. To each process it looks like it has almost all the memory of the system available to it, as if there were only this one process (and the kernel, which might map stuff into the process' memory region).
The exception is shared memory: if both processes share a shared memory region and both processes have the access rights to modify the region, then yes, one process can modify the memory of the other process (but only within the bounds of that shared memory region).
IIRC, it works like this on the lowest level: the kernel manages a list of memory regions for each process. These regionsRegulation of a Purkinje cell-specific promoter by homeodomain proteins: repression by engrailed-2 vs. synergistic activation by Hoxa5 and Hoxb7.
We have previously demonstrated that a short sequence element (L7ATE) within the proximal promoter of a Purkinje cell-specific gene, pcp-2(L7), is required for the normal pattern of expression of the gene in the cerebellum of transgenic mice. The presence of a series of TAAT sequence motifs in this element suggested its interaction with homeodomain proteins. To extend these observations, degenerate oligonucleotides were used to clone by reverse-transcriptase polymerase chain reaction members of the mouse Hox gene family expressed in neonatal cerebellum but not forebrain. Two of these, HoxB7 and HoxA5, are continuously expressed from the neonatal period into adult stages in cerebellar Purkinje cells. These Hox proteins are shown to


Kubernetes 官方本身就提供了一个管理集群的 Dashboard 插件，但是官方的 Dashboard 插件还是有一些局限性，近日360开源了内部使用的 Kubernetes Dashboard 插件：Wayne。 Wayne 是一个通用的、基于 Web 的 Kubernetes 多集群管理平台。通过可视化 Kubernetes 对象模板编辑的方式，降低业务接入成本， 拥有完整的权限管理系统，适应多租户场景，是一款适合企业级集群使用的发布平台。

Wayne 已大规模服务于 360 搜索，承载了公司绝大部分业务，稳定管理了上万个容器。

命名的起源：360 搜索私有云团队多数项目命名都来源于 DC 漫画的角色，Wayne 也不例外，Wayne 是声名显赫的超级英雄蝙蝠侠 Bruce Wayne 的名字。

架构图

整体采用前后端分离的方案，其中前端采用 Angular 框架进行数据交互和展示，使用Ace编辑器进行 Kubernetes 资源模版编辑。后端采用 Beego 框架做数据接口处理，使用 Client-go 与 Kubernetes 进行交互，数据使用 MySQL 存储。

架构图

特性

基于 RBAC（Role based access control）的权限管理：用户通过角色与部门和项目关联，拥有部门角色允许操作部门资源，拥有项目角色允许操作项目资源，更加适合多租户场景。

简化 k8s 对象创建：提供基础 k8s 对象配置文件添加方式，同时支持高级模式直接编辑 Json/Yaml文件创建 k8s 对象。

LDAP/OAuth 2.0/DB 多种登录模式支持：集成企业级 LDAPReality

See me now?

By combining advanced VR rendering, real-time ray tracing, and AI, the Dual GeForce® RTX 2080 will take VR to a new level of realism. Cable management is much improved with VirtualLink, which utilizes an Alternate Mode of USB Type-C™ to provide a quick, single-cable connection for next-generation VR headsets.

． To have the best cooling performance, ASUS DUAL-RTX2080 extends the fansink to 2.7 slots. Please double check you Chassis and Motherboard dimension prior to purchase to make sure it fits in your system! ． Note that the actual boost clock will vary depending on actual system conditions. For more information, please visit http://www.geforce.com

All specifications are subject to change without notice. Please check with your supplier for exact offers. Products may not be available in all markets.

PCB color


phase out coal-fired power plants, and weakening the post-crash Dodd-Frank financial regulations. The Chamber also files briefs in Supreme Court cases and spends huge sums of money to elect pro-business representatives and senators.

Story continues

After the downfall of corrupt superlobbyist Jack Abramoff, Congress passed the Honest Leadership and Open Government Act of 2007. The law required, among other reforms, that industry front groups like the Chamber name any companies or individuals that donated at least $5,000 over a three-month period toward the group’s lobbying work while also actively participating in “the planning, supervision, or control of such lobbying activities.”

According to Whitehouse’s letter, the Chamber boasts on its website about its “Elite” and “C100” membership tiers that give companies a spot on “one of more than 30 U.S. Chamber Policy                                                         to be codified ae Article 6252-9~.
Dear Secretary    White:      ,,   ”                       Vernon’8 Texan Civil Statutcn?

     On Jaauary 1, ~1974. the ~provisione of,House Bill 2’of ,the ,63rd Legislature
(Acts 1973, 63rd Leg.,      ch.


against defects in material or workmanship. The defective product will be replaced or repaired at no charge in either of two ways. This warranty does not cover accident, fire, flood, theft, and we are not responsible for damage resulting from electrical shorts, overcharging or other component defects in vehicle which causes damage or failure to unit. If the Vehicle Identification Number or Operating System has been changed or altered in any way the PCM is not covered under warranty and cannot be returned.

Any PCM/ECM that has been physically altered, painted, holes drilled, cut, etc. cannot be returned under any circumstance.

Info

PSI specializes in the design and manufacture of Standalone Wiring Harnesses for GM Gen II, III, and IV LS based engines and transmissions. These harnesses include the Gen IITerry Brooks is legendary. Legacy. OG. So, when Terry Brooks wants to pop by your website to talk about his new book, you don’t simply say yes, you throw him the keys to the blog with such ardor and glee you nearly break the sound barrier. Here is Mister Brooks to talk about his newest, Street Freaks.

* * *

When I write a book I am always writing about more than the story you read. Street Freaks is no exception – and yet at the same time it is. Almost my entire life’s work has been in the field of fantasy, save for a couple of movie adaptations and a book on writing. Street Freaks is different. You might want to call it science fiction, but since my actual


on the composite surfaces of city streets. There are elite police units with a license to kill.

More important to me than all of these are my efforts to address recognizable social issues that exist today and will almost certainly exist in the future in spite of all our efforts to change the culture. They will wear new clothes and speak different languages and morph into different forms, but they will still be with us. Prejudice is not about to go away because we decry the inhumanity and unfairness of it. Efforts to control people through government oversight are not going to become outdated or shunned by revelations of misuse. Prejudices centering on race, sexual orientation, nationality and religion are here to stay. They have been with us since     2
       The arbitrator is required to “follow applicable law.” The award must be in

writing and the arbitrator must state the conclusions and findings upon which the award is

based. The agreement is expressly “governed by the laws of the State of California

and/or the Federal Arbitration Act [(FAA)], as applicable.”

       ACSC agrees to “pay the fees and expenses unique to the arbitration process, i.e.,

the fees and expenses beyond those [Jeffrey] would have been required to pay” if the

claim had been brought in court. Each party pays their own costs and attorney fees.

However, the arbitrator may include reasonable fees and expenses as part of the

arbitration award to the extent permitted by applicable law.


Development (US), LLC (2012) 55

Cal.4th 223, 246 (Pinnacle).)

        “Both procedural unconscionability and substantive unconscionability must be

shown, but ‘they need not be present in the same degree’ and are evaluated on ‘“a sliding

scale.”’ [Citation.] ‘[T]he more substantively oppressive the contract term, the less

[footnote continued from previous page]
speed, and the ability to choose expert adjudicators to resolve specialized disputes.”
[Citation.]’ [Citation.]” (Id. at p. 1143.)

                                              6
evidence of procedural unconscionability is required to come to the conclusion that the

term isthe parties’ desire for “simple, informal, fast, and cost-effective dispute

resolution.” Clearly, Jeffrey’s discovery rights are greater than the rights afforded the

plaintiffs in Roman and Lane, which the respective courts determined were not

                                             17
unconscionable. It follows that the discovery provision in the present case is not

unconscionable.

       Jeffrey relies on Fitz v. NCR Corp. (2004) 118 Cal.App.4th 702 and Ontiveros v.

DHL Express (USA), Inc., supra, 164 Cal.App.4th 494. Both are factually

distinguishable. In Fitz, the arbitration agreement limited the plaintiff to


obtain further discovery is quite high, permitting additional discovery only

by order of the arbitrator upon a showing of ‘substantial need.’” (Id. at pp. 513-514.)

       The discovery provision in the present case is more favorable to a plaintiff than the

discovery provisions in Fitz and Ontiveros. More individual depositions are expressly

permitted in this case (three) than in Fitz (two) and Ontiveros (one); unlike the plaintiffs

in Fitz and Ontiveros, Jeffrey may propound interrogatories without having to seek the

arbitrator’s permission; Jeffrey has a right to document requests while the Fitz plaintiff

did not; and the arbitrator’s “good cause” standard for allowing additional discovery is

probably easier to meet than Fitz’s “compelling need” or Ontiveros’s “substantial need”

standards. For these reasons, Fitz and Ontiveros are not controlling.

   the money was not in his possession. So did the Wife. The Trial Court
found, as to the money, that “[i]t’s apparently gone . . . .” The evidence does not preponderate
against the Trial Court’s findings. The Trial Court concluded that neither Husband nor Wife
satisfied the burden necessary to show that the other had taken this money. We agree with the Trial
Court.

                The Trial Court never found that Husband had the money. Rather, the Trial Court
stated “I don’t know what happened to [the money].” In short, the Trial Court found that while it
could not tell where the money went, it did find that it was “apparently gone . . . .” Since the money
disappeared


of assets can be considered in formulating a property division that is
equitable.” Hulshof v. Hulshof, No. 01A01-9806-CH-00339, 1999 Tenn. App. LEXIS 653, at *15
(Tenn. Ct. App. Sept. 29, 1999), no appl. perm. appeal filed. Tenn. Code Ann. § 36-4-121
specifically requires the court to consider “[t]he contribution of each party to the acquisition,
preservation, appreciation, depreciation or dissipation of the marital or separate property,...” in
making an equitable distribution. Tenn. Code Ann. § 36-4-121(c)(5) (2002). In the case at hand,
the Trial Court made no finding that the $48,000 had been dissipated and this issue was not raised
on appeal.

                                           Conclusion

                The portion of the Trial Court’s judgment awarding Wife a judgment against Husband
for $24,000 is vacated. The judgment is affirmed as modified. This cause is remanded to the Trial
Court for such further proceedings as may be required, if any, consistent with this Opinion and for
collection of the costs below. The costs on appeal are assessed equally against the Appellant, Carrol
Preston Flannary, and his surety, and the Appellee, Joyce Ann Flannary.


Nelson Keys

Nelson Keys (7 April 1886 in London, England – 26 April 1939 in London) was a British stage and film actor, a star in musical comedy and stage revue, including the 1924 Ziegfeld Follies.

He was the father of film producer Anthony Nelson Keys and director John Paddy Carstairs, who wrote his biography, Bunch in 1941.

Selected filmography
 Once Upon a Time (1918)
 Mumsie (1927)
 Madame Pompadour (1927)
 The Triumph of the Scarlet Pimpernel (1928)
 Splinters (1929)
 Almost a Divorce (1931)
 In the Soup (1936)
 Eliza Comes to Stay (1936)
 Dreams Come True (1936)
 Wake Up Famous (1937)
 Knights for a Day (1937)

References

External links

Category:1886 births
Category:1939 deaths
Category:English male stage actors
Category:English male film actors
Category:English male silent film actors
Category:Male actors from London
Category:20th-century English male actorsproviding dance steps in unison for one song with any number of responses in like manner from the other (or, if more than two music sources are present, even more chaos could ensue in such an instance). In other words, the overall experience is heightened for listeners and spectators alike when these headphone-enabled events are provided with multiple broadcast music sources.
The provision of such a multi-listener multiple headphone event has not been a simple endeavor in the past. The proper development of multiple headphones in a single setting that provide simultaneous access to even a single broadcast channel is the first obstacle. As well, such headphones must exhibit sufficient resiliency to undertake repeated use, not to mention continuous and, at times, rather violent movement, a suitable electrical source


Q:

Fine grained transformation vs coarse grained transformations

Could anyone please explain the difference between fine grained transformation vs coarse grained transformations in context of Spark? I was reading the paper on RDDs (https://www.cs.berkeley.edu/~matei/papers/2012/nsdi_spark.pdf) and not very clear how coarse gained transformation provides fault tolerance in an effective way.

A:

A fine grained update would be an update to one record in a database whereas coarse grained is generally functional operators (like used in spark) for example map, reduce, flatMap, join. Spark's model takes advantage of this because once it saves your small DAG of operations (small compared to the data you are processing) it can use that to recompute as long as the original data is still there. With fine grained updates you cannot recompute because saving the updates could potentiallyan inverted “U” cross section, or half tunnel forms, having an inverted “L” cross section (which can be used in adjacent pairs joined at the edges of their horizontal portions to form an inverted “U”).
In actual practice, use of tunnel forms is labor intensive and therefore expensive. Conventional practice is to seal the tunnel forms against the vertical faces of the starter walls by inserting beams (usually wooden) that span the width of the tunnel being formed (between two adjacent starter walls) and then pounding those beams into place to span and forcibly spread or “smush” the vertical portions of the tunnel forms against the vertical faces of the adjacent starter walls to remove bows or wrinkles out of the tunnel form for accurate placement of block outs.


purely environmental "toxic exposure" cases may represent the other end. Hence, the bulk of "idiopathic" PD cases falls in the middle and will likely involve a mix of genetic and environmental influences. Indeed, there is a very low penetrance of LRRK2 heterozygotic carriers that actually express the PD phenotype; yet, a significant proportion of PD patients carry a LRRK2 mutation, suggesting that such genes might be seen as susceptibility factors \[[@B32]\].

While genetic vulnerability may be seen as providing a backdrop for disease provocation, several compelling lines of evidence suggest that environmental agents, including commonly used pesticides, can act as triggers for the development of PD. In fact, a progressively greater odds ratio for developing PD was associated with pesticide exposure \[[@B6]\], and several other epidemiological studies have implicatedorgans such as the median eminence and area postrema \[[@B65]\]. As well, saturable carrier-mediated transport mechanisms capable of moving IL-1*β* and TNF-*α* may allow for limited penetration of cytokines into the brain \[[@B68], [@B69]\]. Once cytokines gain entry to the brain, they interact with receptors on cells lining the BBB, around the meninges, as well as at vascular areas of the brain \[[@B70]\]. Through volume diffusion, infiltrating cytokines may ultimately penetrate deep within the brain parenchyma \[[@B71], [@B72]\] where they can influence, among other things, neuronal Ca^2+^ channels and MAP kinase and COX-2 signaling \[[@B73], [@B74]\].

Pro- and- antiinflammatory cytokine levels are markedly increased by immune and traumatic insults \[[@B75]\]. In this regard, endothelial cells that line the interior surface of blood vessels and the brain ventricles produce IL-1*β*


enzyme, COX-2, occurs following NF*κ*B activation. In particular, IL-1*β* and TNF-*α* trigger the phosphorylation and degradation of the inhibitory factor, I*κ*B, which normally holds NF*κ*B in an inactive state, resulting in its translocation to the nucleus where it influences (inflammatory) gene expression. In fact, we found that COX-2 deletion markedly influenced the production of cytokines following stressor and endotoxin exposure \[[@B92]\].

Increasingly, cytokines have been implicated in acute and chronic neuronal demise \[[@B91]\]. Indeed, clinical studies revealed augmented levels of proinflammatory cytokines (TNF-*α*, IL-6, IL-1*β*, IFN-*γ*) in postmortem brain as well as in the blood and/or cerebral spinal fluid (CSF) of patients with stroke, head injury, AD and PD \[[@B62], [@B93]--[@B95]\]. A further recent study found that PD patients had elevated basal and LPS-induced blood levels of numerous proinflammatoryfamily member, FasL, and not IFN-*γ*. Of course, these results do not necessarily preclude a role of IFN-*γ* in T cell-mediated dopaminergic neurodegeneration; indeed, FasL is capable of augmenting inflammatory cytokine cascades from microglia (in addition to directly mediating neuronal apoptosis), and Fas receptor expression is potently upregulated in activated microglia following inflammatory insult \[[@B125]\].

In addition to facilitating communication between microglia and peripheral immune cells, IFN-*γ* plays a key role in the activation of oxidative and inflammatory microglial enzyme systems that evolved to protect the host against pathogenic (and possibly xenobiotic) threats to the CNS. Indeed, IFN-*γ* in combination with TNF-*α* induces microglial expression of iNOS and several key subunits of NADPH oxidase \[[@B126]\], as well as the IFN-inducible double-stranded RNA-activated kinase, PKR \[[@B127]\]. Of course, NADPH oxidase


and type of inducing stimulus, likely influence whether NF*κ*B activation has protective or detrimental effects upon neuronal survival or functioning.

4.2. Cyclooxygenase-2 in PD {#sec4.2}
---------------------------

Cyclooxygenase, present in the CNS as COX-1, COX-2 and COX-3 isoforms, is an integral plasma membrane glycoprotein critically involved in the production of PGs from arachidonic acid (AA). The first step in PG biosynthesis involves the conversion of glycerophospholipid into free AA by phospholipase A2, which is ubiquitously present in all brain tissues and whose expression is upregulated by infection or injury \[[@B167]\]. Thereafter, COX metabolizes AA into PGG2 and then PGH2, which is transformed further by terminal synthases into specific PG species. AA is preferentially metabolized by COX-2 to PGE2 (the most abundant PG), whereas COX-1 produces only small amounts of this prostanoid \[[@B168]\].activated microglial cells \[[@B174], [@B196]\]. This, in turn, would of course be expected to exacerbate ongoing DA neurodegeneration.

It ought to be underscored, however, that despite the evidence seemingly linking microglial COX-2 to DA neuronal death, there remains considerable controversy surrounding the relative contribution (and functional relevance) of microglial versus neuronal COX-2 in PD. Indeed, several reports indicated that a JNK-mediated induction of COX-2 in neurons but not microglia is critical for DA neuron cytotoxicity following MPTP treatment \[[@B197], [@B198]\]. Moreover, Teismann and colleagues \[[@B176]\] provided compelling evidence favoring the importance of cell-autonomous oxidative processes (i.e., COX-2-derived ROS, DA-quinone formation) over PG-mediated inflammatory ones in COX-2-dependent neurodegeneration. Similarly, increased neuronal COX-2 activity has been implicated in paraquat-induced neurotoxicity \[[@B179]\]; and, while the regulatory mechanisms subserving neuronal COX-2 induction by


(resolvins and neuroprotectins), appear to antagonize the inflammatory actions of COX-2 and curb proinflammatory CNS responses more generally (e.g., inhibit NF*κ*B, up/downregulate anti/proapoptotic proteins, suppress cytokine synthesis, modulate leukocyte trafficking) \[[@B210], [@B211]\]. It is conceivable that variations in COX-2 signaling that favor EP2/EP4 receptor involvement, and hence DA neuronal survival, might occur in conjunction with certain cytokine profiles and inflammatory responses following DA neuron injury. It might even be the case that the nature of the inflammatory response (involving COX-2 and cytokines) might vary over time following insult, such that there may be a waxing and waning of neuroprotective versus neurotoxic mechanisms engaged.

5. Conclusions and Future Directions {#sec5}
====================================

The findings discussed in this paper provide support for a role of proinflammatory factors, particularly cytokines (IFN-*γ*, IL-1*β*, TNF-*α*) and inducibleseems reasonable.

While it seems undeniable that the inflammatory immune response plays a crucial role in dopaminergic loss and the clinical symptoms observed in PD, it remains to be determined whether neuroinflammation is most relevant to disease process genesis or, rather, is secondarily induced following neuronal injury and thus more critically aligned with shaping the evolution of pathology over time. The emerging picture does suggest, however, that one important mechanism underlying DA neuronal loss in toxin-based animal models of PD involves the (chronic) activation of microglial cells, which through the actions of proinflammatory cytokines and inducible enzymes, mediates the production of damaging oxidative radicals and soluble inflammatory mediators.

While excessive microglial and proinflammatory cytokine driven inflammation can mediate profoundly deleterious CNS consequences, including DA neurodegeneration in PD and its toxin-based


the term containing $\hat\sigmaA$ represents an azimuthal, parity-odd asymmetry analogous to the last term in eq. (\[eqathe\]) but owing its existence to the radiation of the gluon.

For the case of longitudinally-polarised electrons and unpolarised positrons the dependences of these singly-differential distributions on the beam polarisation and c.m.energy are illustrated in Figs. 2(a,b) and 3(a,b) respectively.

(10,4.5) (0.,-2.0) (3.,-2.0)

We present the $\sigma_i$ at  as in Ref. [@OOO]. Fig. 2a shows the distribution in $\cos\theta$ at $\sqrt{s}$ = $M_Z$ for down-type quarks, $y_c=0.02$ and electron longitudinal polarisation $p$ = $+1$, 0 and $-1$. (We refer to positive (negative) polarisation as right- (left-) handed respectively.) The recent SLC/SLD case of $p$ = $\pm0.77$ [@SLDninetysix] is also indicated. The quark polar-angle forward-backward asymmetry is large for high beam polarisation, and its sign changes with the sign ofjet and a second jet origin be identified. It is difficult from an experimental point-of-view to make such exclusive identification for jets of hadrons measured in a detector. Quark and antiquark jets have been identified in predominantly 2-jet events in annihilation (see  [@SLDAFB]). Currently, one has reached a single-hemisphere efficiency for b or $\bar{\rm b}$ quarks of the order of 70%, and a double-tagging efficiency of about 50%. Identification of both quark and antiquark jets in $\rightarrow$ [[${\rm q}\bar{\rm q}{\rm g}\;$]{}]{}events is  more difficult due to the greater hadronic activity.

It is therefore useful to consider more inclusive quantities. Two possibilities are: (1) [*Semi-inclusive*]{}: the quark jet is assumed to be identified, and the [*least energetic*]{} jet in the event is taken to be the gluon and is used


Rep. [**107**]{} (1984) 59.

P.N. Burrows and P. Osland, Phys. Lett. [**B384**]{} (1997) 249.

See, , G. Altarelli , in Physics at LEP, CERN 86-02 (1986), eds. J. Ellis and R. Peccei, p. 1.

See, , T. Kamae, in Proc. XXIV International Conference on High Energy Physics, Munich, August 4–10, 1988 (eds. R. Kotthaus and J.H. Kühn, Springer Verlag, 1989) p. 156.

A. Blondel, in Proc. XXVIII International Conference on High Energy Physics, Warsaw, Poland, July 25-31 1996, World Scientific (1997).

SLD Collab., K. Abe , Phys. Rev. Lett. [**74**]{} (1995) 2890; [*ibid*]{} [**74**]{} (1995) 2895; [*ibid*]{} [**75**]{} (1995) 3609.

SLD Collab, K. Abe , SLAC-PUB-7570, Jun 1997. Contributed to 18th International Symposium on Lepton - Photon Interactions (LP 97), Hamburg, Germany, 28 Jul - 1 Aug 1997 and to International Europhysics Conference on High-Energy Physics (HEP 97), Jerusalem, Israel, 19-26 Aug 1997.

H.A. Olsen, P.Most stores which sell automobile-related products have limited floor space in which to display their products. The typical automobile floor mat is quite cumbersome, bulky, and difficult to place within restrictive small-sized packages. Currently, automobile floor mats are packaged by using an anchor which is clamped or attached to the floor mats to suspend the floor mats on a display bar. Thus, the floor mats are displayed in an unfolded condition such that a consumer may view the mat for color and design features. U.S. Pat. No. 5,257,694, of common assignee herewith and issued Nov. 2, 1993, exemplifies the current state of the art for automobile floor mat packaging. Retailers need an efficient manner to display floor mat packages of this type in their stores. Currently, these floor


in Nuenen. In fact, Dijkstra was the only research fellow of Burroughs Corporation and worked for it from home, occasionally traveling to its branches in the USA.

As a result he reduced his appointment at the University to one day a week. This day, Tuesday, soon became known as the day of the famous “Tuesday Afternoon Club”, a seminar during which he discussed with his colleagues scientific articles, looking at all aspects – notation, organization, presentation, language, content, etc. Soon after he moved in 1984 to the University of Austin, Texas, USA, a new “branch” of the Tuesday Afternoon Club emerged in Austin. Dijkstra worked in Austin till his retirement in the fall of 1999. He returned from Austin, terminally ill, to his original house in Nuenen in Februaryserving coffee to students and making subtle one liner jokes of his own creation.

As a result of his reserved behaviour and uncompromising positions he was disliked by a number of colleagues, in particular in the Netherlands. They saw nothing in his prophet-like statements and biting comments, often delivered from the back of the lecture room, and directed against the hacker’s approach to programming, against the sloppily chosen notation, or expressing his disapproval of the badly organized lecture. Often this scepticism towards his opinions and ideas could be simply explained by plain jealousy that his viewpoints and articles were widely cited and discussed. Consequently, when a prominent speaker was sought for some important event in the Netherlands, Dijkstra was usually passed over.

On a number of occasions, his extreme views