an F(ab′)2 format which lacks the FcγR binding antibody constant region, indicating that antibody effect was by binding to Fcγ receptors and it inhibited p38 MAPK. Our antibody (BI‐204) used in this study was also found to inhibit oxLDL‐induced MCP‐1 release by FcγRIIB (Figure S1). However, BI‐204 specifically inhibited ERK MAPK pathway, so these two antibodies might have different mechanisms of inhibition of macrophage activation (Fig. [9](#jcmm13033-fig-0009){ref-type="fig"}). The detailed molecular mechanism of this difference needs to have further exploration.

![Schematic picture of the oxLDL regulation of MCP‐1 release, and the mechanism of the regulatory effect of oxLDL antibody. oxLDL‐induced MCP‐1 release from monocytes/macrophages is regulated by Ca^2+^ and K^+^ channels, and both of them are TLR‐4‐ and MAPK‐dependent. The oxLDL antibody inhibited oxLDL‐induced Kir channel closure and inhibited the                3
herself conducted “a full and fair hearing,” the Petitioner “has not articulated or identified

prejudice stemming from the [IJ’s] denial” or otherwise shown that the “outcome of her

case would have been different had the motion been granted,” and the record on the whole

supported the IJ’s resolution. (Id. (citation omitted))

       No petition for review was filed with this Court with respect to the BIA’s January

24, 2005 decision. On June 7, 2006, Petitioner did file a counseled motion to reconsider

with the BIA. In a per curiam decision dated August 21, 2006, the BIA dismissed this

motion. It found the motion to be untimely, adding that there were no exceptional

circumstances warranting


before the expiration of the filing deadlines for a

reconsideration motion or a review petition. The BIA ultimately stood by its prior finding

of a failure to demonstrate prejudice, adding that the “explanation for a factual error in the

lead respondent’s affidavit pertaining to whether the lead respondent or her husband was

sterilized in China would not alter our decision.” (Id.) Petitioner never filed a petition for

review with respect to this May 2, 2008 reconsideration ruling by the BIA.

                                              II.

       BecausePetitioner filed the requisite petition in a timely fashion, we have

jurisdiction to review the BIA’s March 7, 2008 decision denying her motion to reopen.

                                               6
See, e.g., 8 U.S.C. § 1252. We, however, lack jurisdiction to review the BIA’s other

decisions, respectively dated May 2, 2008, and January 24, 2005, because Petitioner failed

to file a timely petition of review as to such rulings. See, e.g., id.; Stone v. INS, 514 U.S.

386, 405-06 (1995). We likewise previously dismissed on jurisdictional grounds a petition

to review the


exceptionally advanced seo specelist and Web Developer who works
tirelessly on behalf of our clients and their project needs. i am
recognized as
an exceptionally proficient professional that takes the art and science
of search engine marketing and applies the principals to achieving my
client's goals in a global
market.but not him, because that's his father's and son's actual names), called an Arab "Muhammed", or called a Mexican "Juan". This type of name-calling conflates all members of the ethnicity, which is practically the definition of racism, although I don't think it's considered as bad as using terms related to stereotyped activities (e.g. "spear-chucker" for black men).
However, Fredo may be insulting in multiple ways. Not only is it a stereotypical name, but it's also a weak character in a movie that emphasizes another stereotype, that Italian-Americans are gangsters.
However, I don't think it's an established, idiomatic insult like the N-word. I think Cuomo was exaggerating when he said that this was like the N-word to Italian-Americans. From Vox.com:

But Cuomo is being disingenuous at best when he says that Fredo


923 F.Supp. 851 (1996)
SPECIAL PROGRAMS, INC., Plaintiff,
v.
J. Carlton COURTER, III, in his capacity as the Commissioner of the Department of Agriculture and Consumer Services of the Commonwealth of Virginia, Defendant.
Civil Action No. 3:95CV609.
United States District Court, E.D. Virginia, Richmond Division.
April 15, 1996.
*852 *853 Warren David Harless, J. Tracy Walker, IV, John Willard Montgomery, Jr., Craig Thomas Merritt, Christian & Barton, Richmond, VA, for Plaintiff.
Joshua Noah Lief, David Benjamin Irvin, Anne Marie Cushmac, Edward Paul Nolde, Office of Attorney General, Richmond, VA, for Defendant.

AMENDED MEMORANDUM OPINION
RICHARD L. WILLIAMS, Senior District Judge.
This case is before the Court on cross-motions for summary judgment on the constitutionality of various provisions of the Virginia Solicitation of Contributions statute. For the reasons stated below, the Court declares that the exception from the definition ofwith the substance of the challenge." Commissioner's Reply Brief at 2. He comes to that conclusion because while the Sixth Circuit in Dayton applied strict scrutiny to the plaintiff's free speech claim, see id. at 1481-82, it applied only rational basis analysis to its Establishment Clause claim, see id. at 1483. The Dayton court did so, however, because the Supreme Court, in Corporation of the Presiding Bishop v. Amos, 483 U.S. 327, 339, 107 S.Ct. 2862, 2870, 97 L.Ed.2d 273 (1987), stated that a statute held constitutional under the Lemon test, see Lemon v. Kurtzman, 403 U.S. 602, 91 S.Ct. 2105, 29 L.Ed.2d 745 (1971), and so which did not violate the substantive rights guaranteed by the Establishment Clause need not have its classifications analyzed under strict scrutiny;


to a specific fact pattern involving an anti-picketing statute that made an exception for labor picketing. For that reason, the rule quoted above from Carey is rather narrow, although even it talks about "discriminat[ion] among speech-related activities" requiring strict scrutiny and does not limit itself merely to content-based distinctions, although it was such a distinction which was held unconstitutional in Carey. Nothing in Carey limits, however, the broad rule enunciated in Mosley, and reaffirmed in Plyler and Austin that strict scrutiny applies to all legislative distinctions which impinge upon a fundamental right.
Turner Broadcasting is even more inapposite, because it is not even an Equal Protection Clause case. In Turner Broadcasting, the plaintiff sought to have the "must-carry" provisions of the 1992 Cable Act struck down as unconstitutional becauseby the statute must withstand strict scrutiny.
The Commissioner argues that a very similar provision was upheld by the Second Circuit in National Awareness Found. v. Abrams, 50 F.3d 1159, 1167 (2d Cir.1995). It is true that the statute at issue in National Awareness distinguished between professional solicitors and employees of charitable organizations. But the burden imposed by the statute was small  professional solicitors had to register with the state and pay an $80 fee  and charitable organizations had to register with the state and pay registration fees under other related statutory provisions. See id. at 1168. The provision at issue was "designed to regulate independent professional solicitors who are not otherwise regulated." Id. The Commissioner notes that charitable organizations must register pursuant to VA.CODE ANN. §


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  James from Storm ever reads this, he has to get off his keister and start bottling and/or canning his own beers because his stout and ipa would be welcome additions in the fridges of many. Especially mine! (1,040 characters)


Resources

Market News

August 29, 2016TTIP has failed -- but no one is admitting it, says German Vice Chancellor.

The free trade negotiations between the European Union and the United States have failed, but "nobody is really admitting it", Germany's Vice-Chancellor Sigmar Gabriel has said.

Talks over the so-called Transatlantic Trade and Investment Partnership, also known as TTIP, have made little progress in recent years.

The 14th round of negotiations between American and EU officials took place in Brussels in July. It was the third round in six months.

At the time, the talks were thought to be in trouble after a number of leading European politicians expressed concern about TTIP's effects and the US's reluctance to accept changes to the proposed deal.

In May, cracks emerged when France threatened to block the deal.

President HollandeIraq right on schedule

Vieira says he and his players have been preparing for the final from the very start.

29 Jul 2007 12:36 GMT

]The 'Lions of Mesopotamia' jog during warm up before the July 29 final in Jakarta [AFP]

Iraq continue to keep their Asian Cup dream alive as they settle in Indonesia, the third country they have had to play in, ahead of their meeting with three-time champions Saudi Arabia in the final on Sunday.

The players sang songs together on the team bus as they travelled to Friday night training, then continued their relaxed preparation with a playful kick-around before coach Jorvan Vieira put them through their paces in a session that was left open to the media for the duration.

It has become increasingly obvious that the Iraq contingent


strike pattern among 48 Kalenjin-speaking participants from Kenya who varied in age, sex, body mass, height, running history, and habitual use of footwear.There was no effect of sex, age, height or weight on foot strike angle, but individuals were more likely to midfoot or forefoot strike when they ran on a stiff surface, had a high preferred stride frequency, were habitually barefoot, and had more experience running.It is hypothesized that strike type variation during running, including a more frequent use of forefoot and midfoot strikes, used to be greater before the introduction of cushioned shoes and paved surfaces.

ABSTRACTRunners are often categorized as forefoot, midfoot or rearfoot strikers, but how much and why do individuals vary in foot strike patterns when running on level terrain? This study used generalpromote conservative public policies based on the principles of free enterprise, individual freedom, traditional American values, and a strong national defense.”] Australia’s score is now the highest in the 34-nation OECD. A Labor government? Holy handguns! How did this happen?

7. Australia is one of four countries in the Organisation for Economic Cooperation and Development (OECD) to have unemployment below 5.5% and job participation above 75%. Which are the others? What else distinguishes them?

8. Australia is one of only three nations in the OECD and G20 economies with interest rates in the optimum range between 1.75% and 4.75%. Only Australia has maintained this through the global financial crisis. How? What can Australia do now that was never possible before?

9. Australia is the only developed country to have had continuous


guys live in a bubble and it's very hard, a lot of people don't understand how people feel within these situations," he said.

Advertisement

Blimey. It is February. Jaromir Jagr is scoring goals for the Czech Republic at the Olympic Games. Here are the names tearing it up on NAB Challenge fields: Langdon; Miles; Michie.

I know we all love our footy, but let's take a deep breath.

Let's skewer, pierce, slash, explode that terrible 'bubble' constricting our footy players! Who created it? Who wants it? Get rid of the bubble!

It is February. It is 25 degrees at night. Do we really need this level of angst over a 'leadership group' demotion now? Or at any time? Have we all lost our collective sports minds?

If Jack Riewoldt thinks he is so poorlyRecovery is proceeding slowly since I have been unable to completely rest, but things do seem to be improving.

People following git will have noticed that I recently posted a TODO file containing all the blocker issues for E19 release. As of the posting of this article, there are only 6 items remaining, totaling 11 issues. This is not to say that there are not other issues, or that no other changes will occur; indeed, issues are being resolved as they are discovered.

Trying to conserve wrist power, so this will be another short post. For those who didn’t see, this blog and future E blogs are now accessible at http://e.zmike.ninja to provide a single address for following the latest development news.


During a July 12 NATO summit it condemned Iran for harmful acts and its nuclear program.

On July 12, Sigal P. Mandelker, undersecretary for terrorism and financial intelligence at the U.S. Treasury, told journalists in Dubai that we wanted to disrupt the "despicable use of Iranian revenue" across the Mideast.

"You've seen the Iranian people, of course, stand up loudly, at risk of their own lives, shouting in protest about the corruption that's happening within Iran … Of course the fact (is) that so much money has gone to support malign activities elsewhere, with very little focus on the economy itself."

It is critical to find a way to accelerate regime change by Iranians. They seek free access to the internet and messaging applications like Telegram. Its main appeal is security.against Tehran, per Tanter in Newsmax.

This ongoing crisis is an opportunity to change the regime from within. The people are in the streets to make their revolution happen, and they need political and technological support of the West.

There are three ways for Iranians to effect peaceful overthrow of the regime. At issue is when, not whether.

First, demonstrations beginning in December 2017 peaked during January; they were followed by a rising tide of protests, largely unreported by the media. They resemble 1979 ones, which effected the Islamic Revolution.

If one were to plot the curve of demonstrations, it would resemble a series of asymptotes of a hyperbola like mountain peaks, followed by valleys below, which are steadily rising with each iteration. A hyperbola is an open curve, which means branches


of curves continue to infinity.

Applied to Iran, protests gradually rise, and hence are overlooked, as “just noticeable differences,” small changes, barely noticeable, and rarely described in the media.

Second, current demonstrations indicate Iranian protestors have turned the tide against Tehran. In "Every War Must End" Fred Ikle states wars end because one side emerges victoriously over the other, or both sides are exhausted from fighting.

Third, and likewise, every dictatorship must fall: One side appears successful over the other, or both are tired of struggling. Moreover, Iranians hold the unpopular regime in contempt. Indeed, rulers pay attention to a coalition of oppositionists, like the National Council of Resistance of Iran (NCRI) about twice as much as to other dissident groups. See "Appeasing the Ayatollahs."

The Way Forward

Per interviews conducted by yours */

static inline void
aarch64_frob_update_context (struct _Unwind_Context *context,
			     _Unwind_FrameState *fs)
{
  if (fs->regs.reg[DWARF_REGNUM_AARCH64_RA_STATE].loc.offset & 0x1)
    /* The flag is used for re-authenticating EH handler's address.  */
    context->flags |= RA_SIGNED_BIT;
  else
    context->flags &= ~RA_SIGNED_BIT;

  return;
}

#endif /* defined AARCH64_UNWIND_H && defined __ILP32__ */


these conditions.

The laboratory/research team will process a second lithium heparin sample, drawn by the research nurse, 1 hour (±30 min) after the initial prehospital blood draw. For this sample, the local laboratory personnel/research team will centrifuge the blood sample and the plasma will then be divided into separate aliquots. This will then be stored in the freezer within 8 hours of collection. As above, samples will be stored pending subsequent analysis in batches.

Plasma will later be analysed for POC troponin assays, as follows: Abbott i-Stat troponin I and LumiraDx troponin I by the central study team. Leftover plasma will continue to be stored at the central study site to permit evaluation of additional, new POC troponin assays when developed.

Participant selection {#s2-6}
---------------------

We will prospectively approach patients who have called for an emergency(999) ambulance with symptoms that the attending paramedic suspects may have been caused by an ACS.

### Inclusion criteria {#s2-6-1}

-   Adult patients (\>18 years).

-   Called 999 for an emergency ambulance because they have experienced pain, discomfort or pressure in the:

    -   Chest.

    -   Epigastrium.

    -   Neck.

    -   Jaw.

    -   Upper limb without an apparent non-cardiac source (compatible with the American Heart Association case definitions).[@R9]

-   Attending paramedic suspects these symptoms may be caused by ACS.

### Exclusion criteria {#s2-6-2}

-   Patients with unequivocal evidence of ST-elevation myocardial infarction who are being immediately transferred for primary percutaneous coronary intervention.

-


Stan Lee and David Pearson gone on the same day. What a double whammy.

Pearson was the greatest driver of his generation, not Petty. Even Petty said he was a better driver than Petty. If he'd decided to run all the races instead of cherry-picking the ones that paid the most (can't blame him, as the schedule had 60+ races back then, in every backwoods hick town with a bullring), he'd easily have more championships than Petty's 7.Intermediate technology of manufacturing suturing needles as visualized by SEM.
The manufacture of a suturing needle either from a 0.24 mm phi stainless steel capillary or a 30 G injection needle, as examples of an intermediate technology appropriate for developing countries, is followed step by step with the SEM.


emphasized that such statistics are "not related to incidents that directly affected foreign visitors" to places such as Cancun. The U.S. State Department also has recognized that many "homicides appeared to be targeted, criminal organization assassinations."

But "turf battles between criminal gangs have resulted in violent crime in areas frequented by U.S. citizens," and "shooting incidents injuring or killing bystanders have occurred."

The tropical coastal town of Cancun, which is perched along the Caribbean Sea in southeastern Mexico, attracts millions of Americans to its warm beaches each year.

The U.S. government issued a travel advisory earlier this year for several popular tourist spots in Mexico, including Cancun — which is known as the spring break capital of the country. The advisory said Americans should "exercise increased caution" because of widespread violentAmazon's Echo is the current standard for smart home assistants -- with some new competition from Google Home, of course -- thanks to its ease of use and surprisingly good voice-controlled personality, named Alexa.

But while the Echo (and the Echo Dot and Tap) are Amazon-made products, Alexa herself is slipping the bonds of corporate exclusivity and turning up in a handful of other products. We've already seen the Triby smart radio: Now Lenovo has the Smart Assistant.

Sarah Tew/CNET

It's not a very catchy name, but one look will tell you this is clearly modeled on the Echo. It's a tall cylindrical device, but with a warmer design than Amazon's severe speaker. The top half is white, with a silver 360-degree microphone-speaker combo on top. The bottom half feels more


Since December 2017, we have been adding new digital assets to the platform on a regular basis. DAA managers now have up to 73 digital assets to choose from and present to our users through their diversified baskets of cryptocurrencies, or Digital Asset Arrays.

We have been receiving requests over email and at different conferences and events from blockchain companies who want to list their tokens on our platform. We are always open to cooperating with and supporting strong projects, especially ones our DAA managers and users want.

Before adding a proposed digital asset to the ICONOMI platform, we follow a due diligence process based on internal protocols in which we look at several criteria. In general, we look for digital assets that:

Are supported on a major, high-volume exchange Havewriting." "It's so tiny." "(O'Neill) What does it do?" "(Carter) It's maintaining an interior temperature of 33st Fahrenheit." "It's generating an electromagnetic field and emitting small amounts ofradiation." "Well, I knew that." "Why does it do that?" " I'm trying to make a threat assessment." " I don't know what it is,... ..but it's got a power source more advanced than anything we've ever seen." "It's a time capsule." "Well, that's an educated guess, but..." "Imagine your civilisation is facing a great cataclysm and you know it." "Wouldn't you leave something behind that told whoever came after who you were?" " Or how you died." " Imagine what you could learn... ..about your own fate." "When a Goa'uld's world is taken by another,... ..he may leave behind the


"We would survive." "O'Neill desires this... ..as well." "He wishes... ..to live." "But what of us?" "P4G-881 !" "It's primordial." "Lots of oxygen and sunlight." "Like this world was a quarter of a billion years ago." "We can't open the Stargate without the computers." "You would send us there?" "Through your Stargate?" "We would." " For what reason?" " So that we both may survive." "We'll take you there ourselves!" "Please!" "(technician) Everything just shut down!" "God help us." "Auto self-destruct in two minutes." "Sir, I think the computers are rebooting!" "Start dialling P4G-881 as soon as they're up!" "Yes, sir." "(Stargate alarm)" "Auto self-destruct in one minute 30 seconds." "Chevron one engaged." "Chevron two engaged." "Chevron three engaged." "Chevron four engaged." "Auto self-destruct in one minute." "ChevronBright Hues

If you choose to wear a bright color, Brett suggests you keep the makeup crisp, but neutral, so the attention is drawn to the clothing. And when experimenting with bold makeup colors, resist the urge to be matchy-matchy.


lens elements there have been proposed various methods for varying an optical property of a fluid lens element for integration into an optical system.
According to a process of electro wetting, a fluid lens element is provided having at least two immiscible fluids and a voltage is applied to the fluid lens element. A surface tension of the fluid lens element changes as a result of the voltage being applied, bringing about a change in the curvature of an interface between the at least two fluids.
In U.S. Publication No. 2008/0144185, a fluid lens element is described having a deformable membrane partially defining a cavity that holds optical fluid. An actuator assembly comprising an actuator is provided for imparting a force on the deformable membrane.http://digitalcommons.law.villanova.edu/thirdcircuit_2009

Recommended Citation
"Alleman v. State Farm Life Ins" (2009). 2009 Decisions. Paper 1123.
http://digitalcommons.law.villanova.edu/thirdcircuit_2009/1123

This decision is brought to you for free and open access by the Opinions of the United States Court of Appeals for the Third Circuit at Villanova
University School of Law Digital Repository. It has been accepted for inclusion in 2009 Decisions by an authorized administrator of Villanova
University School of Law Digital Repository. For more information, please contact Benjamin.Carlson@law.villanova.edu.


                                      -4-
affidavits show that there is no genuine issue as to any material fact and that the movant

is entitled to judgment as a matter of law.” Fed. R. Civ. P. 56(c); IFC Interconsult, AG v.

Safeguard Int'l Partners, L.L.C., 438 F.3d 298, 317 (3d Cir. 2006).

       Because subject-matter jurisdiction is based on the diversity of citizenship of the

parties, because the parties agree that Pennsylvania law governs this dispute, and because

the policies in question were purchased in Pennsylvania, we look to the substantive law of

Pennsylvania to determine509

F.3d at 169 (citing Madison Constr. Co. v. Harleysville Mut. Ins. Co., 735 A.2d 100, 106

(Pa. 1999)). By contrast, an unclear, ambiguous provision will be construed against the

insurer and in favor of the insured. Id. (citing Madison Constr. Co., 735 A.2d at 106).

       Contractual language is ambiguous if it is reasonably susceptible to different

constructions and capable of being understood in more than one sense. Madison Constr.

Co., 735 A.2d at 106. In determining whether a contract term is ambiguous, a court must

consider the actual words of the agreements themselves, as well as any alternative


Founded 32 years ago, Nigerian capital Abuja was a utopian dream. But it became marred by corruption and few could afford to live there. Today, as the cranes return, its new minister is attempting to forge a truly African city.couple of ordinary races, and Red Bull is not a comforting environment in those circumstances, to say the least.

Ferrari, Leclerc down but not out

Lando Norris has had two outstanding races to begin his McLaren career, and was rewarded with sixth place. Another wise calm head on young shoulders, like Leclerc. I can see Lando, Alex Albon and George Russell around for a good while. And great to see McLaren turning the corner too.

Renault had a doomed one-stop strategy for Daniel Ricciardo, who is having a nightmare start to his new career phase sadly, and Hulkenberg has not been much luckier. There's a team that needs a result in China next time out.

Kimi Raikkonen is just in a happy place with the combo of F1 car, wife, child and


lies beyond, shadowed along its southern length by a grandstand that meets the façade for height and has the effect of reducing the pool’s size and forming, in a word, a ‘cauldron’. (The KFC sponsored Breakers, who are at pains to give their fast-food benefactor utmost coverage – even going as far as to remodel their logo this season from a breaking wave to a rooster – colloquially refer to this, their home venue, as “the Deep Fryer”, rather apt were the mercury not falling toward single digits this evening). Ten or so metres from each end, the pool is bisected crossways by lane-ropes connected to a netted goal, ensuring the ‘playing field’ is centred for ideal viewing.

On the palm tree lined grassy verge opposite the stand a1. Field of the Invention
The invention relates to a portable arrangement for ensuring privacy during use of a public toilet. The arrangement includes a screen in the form of a generally rectangular or square piece of sheet material with an embedded suction cup or other attachment means at each corner. Secured to the screen is a smaller pouch into which the screen can be folded and secured by a zipper for transport.
The sheet material is dimensioned to extend across the width of the door of a public restroom stall, to cover a substantial part of the vertical gaps, openings, or slots formed between walls of the stall and vertical edges on each side of the door, and to be held in position by adhesion of the suction cups


the following applies:
(1) It is defective due to inadequate warning or instruction at the time of marketing if, when it left the control of its manufacturer, both of the following applied:
(a) The manufacturer knew or, in the exercise of reasonable care, should have known about a risk that is associated with the product and that allegedly caused harm for which the claimant seeks to recover compensatory damages;
(b) The manufacturer failed to provide the warning or instruction that a manufacturer exercising reasonable care would have provided concerning that risk, in light of the likelihood that the product would cause harm of the type for which the claimant seeks to recover compensatory damages and in light of the likely seriousness of that harm.
.   .   . No, I wouldn'tI would have never thought this would have happened to a kid, never.
McClung Dep. at 144-46, 247. Based on this testimony, it is not entirely clear whether Ms. McClung ever read the warnings on the highchair. Although she testified that she was unaware of the warning, she also testified that she did not recall whether there was a warning on the back of the highchair at all. A reasonable jury could conclude that Ms. McClung did read the warning on the highchair but she disregarded it because she thought she already knew how to use the highchair properly. A jury could therefore interpret her testimony to support Plaintiffs' contention that Ms. McClung did read the warnings, but failed to heed them because they inadequately warned of


that a caretaker would leave a child unattended while caring for other children in an upstairs room. A reasonable jury could also conclude that Matthew would have suffered his injuries even if Ms. McClung had been caring for a legal number of children on January 3, 1997, because she still would have left him unattended while tending to other children upstairs.
Second, section 302B of the Restatement (Second) of Torts is not clearly relevant to this case, and even if it is, it explicitly states that criminal conduct of a third party may be foreseeable. Section 302B states the following: "An act or an omission may be negligent if the actor realizes or should realize that it involves an unreasonable risk of harm to another through the conduct ofdamages claim as to Defendant Penn Traffic; Defendants' Summary Judgment Motion is DENIED in all other respects.
IT IS SO ORDERED.
NOTES
[1]  Ohio has also adopted Section 402A of the Restatement (Second) of Torts, which sets forth strict liability for torts. See Temple v. Wean United, Inc., 50 Ohio St.2d 317, 364 N.E.2d 267, 271 (1977); Restatement (Second) of Torts § 402A (1965). A strict products liability claim in Ohio traditionally required proof of the following three elements: "(1) There was, in fact, a defect in the product manufactured and sold by the defendant; (2) such defect existed at the time the product left the hands of the defendant; and (3) the defect was the direct and proximate cause of the plaintiff's injuries or loss." State Auto Mut. Ins.


laboratories, equipment and a government which is receptive to their ideas and which is willing to transform and introduce new modern systems," the Union Science and Technology Minister said.

Harsh Vardhan claimed hundreds of scientists have come back to India and a lot more were willing to come (back), adding "It is a very very happy moment".

He said Prime Minister Modi's goal was to deliver a 'New India by 2022' towards which he was working with a lot of passion,vision and sincerity and dedication.

The Prime Minister, he said, has been extending a lot of support for development of scientific institutions and research in the country.

He said the scientific community would always be indebted to PM Modi for the support received for development of scientific activities, fellowships and new initiatives.

"Ideasfrom young minds have been supported, right from the seed stage to entrepreneurship programmes," he said.

Harsh Vardhan said strengthening inputs into research had also seen drastic improvements over the years and funding had also increased significantly over the last three-four years.

"He (PM Modi) has given a clear cut vision to the scientific community of scientific social responsibility," Harsh Vardhan said and emphasised that CDFD should strive to be the best in the globe in the next couple of years.


in 2011, Baldwin gave a simple explanation for how he ended up at Stanford: "They were the only D-I school that recruited me. The only one."But how the Cardinal discovered Baldwin is rather an unlikely story. Had it not been for a former NFL coach and a newspaper publisher, Baldwin's talents may have never been noticed.But back when Baldwin was a little-known receiver at Gulf Breeze High School, Kevin Doyle, a former sports writer who became the publisher of the Pensacola News Journal, was at a game along with friend and former Buffalo Bills head coach Kay Stephenson, whose daughter went to the school. Both were impressed with Baldwin, so Doyle called his son Matt, who happened to be Stanford's director of football operations, and that led toresearch organisations have developed various methods to make this process user friendly and manageable from the data cleaning angle and flexible enough to be re-usable for different studies. According to ICH-GCP guidelines \[[@ref6]\], certain features of data capture practices are requested; therefore, users in this field expect a system to provide these standards.

A user has the possibility to design, develop, and conduct clinical trials using ObTiMA. This software goes far beyond a pure data management system. A screenshot is shown to give a first overview of the functionality of ObTiMA and shows the main menu items of the p-medicine platform ([Figure 1](#figure1){ref-type="fig"}). ObTiMA is available at: <http://obtima.org/>. ObTiMA is based on the HDOT (Health Data Ontology Trunk) ontology \[[@ref7]\].

The tool includes several canvases for graphically representing both the


schema of the database to align, HDOT, and the mappings between views from both models.

Ontology Annotator
------------------

The p-medicine project incorporates a data integration layer designed to offer researchers a homogeneous view of disparate biomedical data sources---that is, clinical databases, genomic data sources, image repositories, etc. The homogenisation process of the integrated sources is based on a semantic annotation of the source schemas---that is, the alignment of its elements with the HDOT ontology, which acts as a common vocabulary. These semantic annotations are manually defined by end-users. To assist users in the annotation process, the p-medicine platform includes a specific-purpose tool: the OA \[[@ref8]\]. The OA is a web-based tool with a graphical interface that allows users to visually navigate through an RDF-based (RDF: resource description framework, <http://www.w3.org/RDF/>) database schema intervention integrity

2.  software updates and compatibility

3.  web accessibility challenges

4.  hardware and equipment challenges

5.  computer literacy of participants

6.  programming challenges.

Importantly, these challenges also cover environmental factors and not only factors directly related to the software. To be successful on the market, usability tests have to cover such challenges as well.

Safety is a further aspect that needs to be taken very seriously in the health-care sector \[[@ref17], [@ref18]\]. The American Medical Informatics Association (AMIA) Board of Directors convened a task force on usability to examine evidence from literature and give recommendations to reduce or avoid unintended consequences or harm caused by electronic health records (EHR). They summarised their findings in ten recommendations that are categorised into four areas and listed as follows:

1.  Human


the p-medicine tools within the ECRIN infrastructure. Thus, ECRIN together with other p-medicine members started its process from the description of user needs and requirements. On the basis of these efforts, which have been reported during the project's lifecycle, scenarios, use cases, and quality reports have been defined to establish requirements for the usability in the ECRIN infrastructure, which in other words means to establish GCP compliance in p-medicine. P-medicine met the requirements for security, legal and ethical framework, that are the base for a correct data use in an international framework. Developers were interviewed to evaluate and establish the tool maturity status; the questionnaire was divided into five sections: software development process, continuous delivery, specification, testing, and quality management and support documents. Each section was then dividedat the investigator site, and the configuration management during the system's operational use. The usability of the system at the investigator site is of prime importance for GCP. Therefore, it must be determined for what purposes the site uses the newly installed software applications, which of these purposes are in need of GCP compliance, and if a mix of GCP and non-GCP purposes is intended. Usability is assured by appointing, training, and organising an adequate number of competent staff to use the systems according to GCP standards, including the provision of SOPs, instruction sheets, on-line help, and support hotlines. Nonetheless, the users' compliance with the proper procedures for the GCP system has to be checked. For the evaluation of ObTiMA and OA as part of the clinical trials


                                            Can be solved by the use of a legend
  Missing reaction from the system, only refresh of the system is not the expected reaction                                      Improved system response in the new version
  Reaction of the system not visible for the user--- doing action once more resulting                                                                 This has actually to do with the portal implementation and the way they access the OA tool. Discussions between the OA development team and the p-medicine portal developers will take place in order to optimize the visualization area of the OA, removing unnecessary parts (e.g., moving the OA description to a separate window)
  HDOT module pop-up window is very unusable


780 N.W.2d 801 (2010)
PEOPLE of the State of Michigan, Plaintiff-Appellee,
v.
Charles Eugene PORTER, Defendant-Appellant.
Docket No. 140410. COA No. 287141.
Supreme Court of Michigan.
April 27, 2010.

Order
On order of the Court, the application for leave to appeal the December 1, 2009 judgment of the Court of Appeals is considered, and it is DENIED, because we are not persuaded that the question presented should be reviewed by this Court.
before March 17, 2017, and it

is FURTHER ORDERED that the trial court notify this Court as to the date upon which the

appellate record was made available to appellant. See Kelly v. State, 436 S.W.3d 313

(Tex. Crim. App. 2014).

       Appellant’s motion for extension of time to file a pro se brief is GRANTED.

Appellant shall have thirty (30) days from the day the appellate record was first made

available to him to file his pro se brief with this Court. The State shall have twenty days

thereafter to file its response, if any.

       IT IS SO ORDERED.


museum site to be completed within 21 months (Dec 2018) from the contract award date (status as of 27 Nov 2017).

See also

 Haryana State Museum at Panchkula
 Asigarh Fort at Hansi
 Pranpir Badshah tomb, Panchyat Bhawan in Hisar Govt College ground
 Haryana Rural Antique Museum at HAU Hisar
 Jahaj Kothi Museum at Hisar fort
 Sheikhpura Kothi near Hansi
 Dharohar Museum at Kurukshetra University
 Kurukshetra Panorama and Science Centre at Kurukshetra
 Shrikrishna Museum at Kurukshetra
 Rewari Railway Heritage Museum at Rewari railway station

References

External links
 Indus Valley Civilization video channel
 Indus Valley Civilization video by history channel
 Indus Valley Civilization video

Category:Museums in Haryana
Category:Tourist attractions in Hisar district
Category:Buildings and structures in Hisar district
Category:Indus Valley Civilisation       HOW_MANY_DAYS_FOR_ONE_WEEK = len(LIST_OF_DAYS)
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                RESET_COUNTER = 0
                for i in range(REPEATS):
                    self.id = ''.join(random.choices(string.ascii_letters, k=30))
                    self.calendarydays = onDay(self.calendarydays, LIST_OF_DAYS[RESET_COUNTER])


who melted the wall between traditional political power and modern media celebrity. For a long time, they got what they paid for.

However, after the assassinations and after the dead woman in the car, the country started to get exhausted. It stopped treating the Kennedys like a public political treasure and began to treat the Kennedys like a public cultural bauble, not entirely different from Liz and Dick or, most recently, the Osbournes. They still provided the occasional media spectacular - Rose's funeral or John F. Kennedy Jr.'s sudden death. Otherwise, though, they were just a family, famous, surely, but also deeply troubled, full to the gun wales with drunks and lay abouts and public junkies. Edward Kennedy flamed out against President Jimmy Carter in 1980, and the rawstudies in the United States.) As a political issue, the protection of human subjects in medical research was the cutting edge of the cutting edge.

One night at about 8, just as he was getting ready to go home, a young aide on the Labor Committee named David Bowen prepared a briefing book to show to Kennedy the next morning. He showed it to his boss, a longtime Kennedy aide named David Nexon. There's only one thing missing, Nexon told Bowen: a legislative history of whatever Kennedy had previously done on the subject. Bowen went back to work.

"At about 3 o'clock in the morning," Bowen recalls, "I came to the realization of the depths of his involvement in these things." Kennedy had held the first congressional hearings into the


a charge trap flash (CTF) memory using, instead of the floating gate, an insulating layer including a charge trap site, e.g., silicon nitride Si3N4, as a charge trap layer, which may trap electrical charges, has been developed.
During programming of the CTF memory, implanted electrons are trapped in the charge trap layer and localized therein. The injected electrons are thermalized in a deep trap and spatially spread in a nitride film. Accordingly, because the threshold voltage of the CTF memory changes as the electrons are thermalized and spread in the nitride film, e.g., during the thermalization of the localized electrons, time is needed until the threshold voltage Vth is fixed.
Therefore, in the CTF memory, the threshold voltage Vth characteristically changes according to time due to the movement of thevoltage before the verification. If the target threshold voltage is verified to have not been reached, a program voltage that is increased by ΔVpgm is applied for programming so that an over-program occurs in which the threshold voltage excessively increases. Accordingly, the distribution of the threshold voltage of the program state increases.


intake at the VOADV shelter at 1812 Federal Street in Camden, and that the project is “changing the paradigm of how we provide social services.

“Clients don’t do well with fragmented care,” McKernan said. “It’s our responsibility to make sure that they are engaged and led into services that they want to participate in.”

McKernan said the agency will measure the success of the program by tracking the number of times its representatives encounter people on the street, how many engagements people have before they join the program, and how many enroll in services overall.

“A lot of that is relationship-building,” McKernan said.

“I see us as navigators, advocates, and being the person who helps.”

At the Cathedral Kitchen in Camden City, representatives from VOADV and a dozen or more city, state, county,income.

“It’s difficult because it’s hard for me to get food and accommodation,” Onadipe said. “They told me I need to wait for 30 days until the Board of Social Services can help me.”

Sixty-two-year-old Darrell Dupree said he’s lived in Camden City all his life, but has spent the last three or four months homeless.

Dupree had a place to live for a while, but “there was no more room,” and now he’s on the streets.

He has daughters in the area, but said, “they’re handling their own lives” and he doesn’t want to intrude.

Dupree collects Social Security, but doesn’t have enough money to make rent in the city.

“They’re tearing down a lot of stuff, but they’re not building enough places for people to live,” he said. “They’ve got people coming


from everywhere because Camden is the place where they can get housing. But after that, then you’re stuck sleeping outside.

“Then you’ve got the cops,” Dupree said. “They don’t want you laying here, laying there; they wake you up, and you wind up going back. I had a guy at 4th and 101 punch me in the head for no reason, telling me I woke him up. This is nobody’s home.”

Dupree, who worked as a cook most of his life, said he’s tried to enroll in services before but found himself stonewalled at various points of the process. He believes his circumstances are not uncommon.

“It’s hard getting in the plan, period,” he said. “I don’t have receipts for where my money went. If I’m addicted to drugs or alcoholwho’s gonna give a receipt for that?”

“A lot of people don’t even think like that,” Dupree said.

“They think, ‘They’re going to ask me a bunch of questions and turn me the other way.’ I don’t know.”

Erin Crean, Camden County’s Director of Community Development, said the problem of homelessness in the city is “humbling.”

In the summer, many people camp out in wooded areas or under overpasses; in the colder months, they frequent “abandon-miniums,” the city’s empty homes and warehouses, seeking shelter from the elements, she said.

“People migrate, and they are habitual,” Crean said. “We see the same people in the same locations.”

Crean is hopeful that the VOADV navigator will help agencies locate and care for the homeless, the better to enroll them into services. She related the story of


direct pipeline to homelessness,” Keashen said.

“The biggest thing, more than anything else, is having an umbrella to our nonprofit vendors,” he said.

In addition to providing services and tracking data on the issues around homelessness, the independent agencies with which the county government can partner often have access to their own sources of funding.

A $650,000 federal justice grant will provide the basis for a post-prison re-entry program the county will roll out in the fall; that will be supplemented further by the $2-million state grant that backs the Volunteers of America navigator and re-entry programs.

The day-work programs are part of a $40,000 line item in the county budget for parks cleanup and other services. The county Homeless Trust Fund will also be tapped to seed future initiatives, Keashen said.

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    return html;
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When I submit the form, the HTML is generating right, and I can see my content. But, I can't click on any entries of the
. Moreover, when I want to see the sourcecode of my page, it doesn't displays me the table, but still my form, even if it has still been validated.
Could someone explain me what I do wrong here ?

A:

Depending on which jQuery version you're using, you need to either bind the click event using jQuery.delegate or jQuery.on in order for things to work with dynamically added DOM elements.
Edit: as pointed out by Geert Jaminon, you have to use the selector parameter of the on


y[n] = b0 * x[n] + b1 * x[n-1] + b2 * x[n-2] + a1 * y[n-1] + a2 * y[n-2]

 A Direct Form I algorithm is used with 5 coefficients and 4 state variables per stage.

Single Biquad filter stage

 Coefficients b0, b1, and b2  multiply the input signal x[n] and are referred to as the feedforward coefficients. Coefficients a1 and a2 multiply the output signal y[n] and are referred to as the feedback coefficients. Pay careful attention to the sign of the feedback coefficients. Some design tools use the difference equation

    y[n] = b0 * x[n] + b1 * x[n-1] + b2 * x[n-2] -a1 * y[n-1] - a2 * y[n-2]

 In this case the feedback coefficients a1 and a2 must be negated when used with the CMSIS DSP Library.

Higher order filters are realized as a cascade of second order sections. numStages refers to the number of second order stages used. For example, an 8th order filter would be realized with numStages=4 second order stages.

8th order filter using a cascade of Biquad stages

 A 9th order filter would be realized with numStages=5 second order stages with the coefficients for one of the stages configured as a first order filter (b2=0 and a2=0).

The pState points to state variables array . Each Biquad stage has 4 state variables x[n-1], x[n-2], y[n-1],


instance structure use

    arm_biquad_cas_df1_32x64_ins_q31 S1 = {numStages, pState, pCoeffs, postShift};

 where numStages is the number of Biquad stages in the filter; pState is the address of the state buffer; pCoeffs is the address of the coefficient buffer; postShift shift to be applied which is described in detail below.

Fixed-Point Behavior

Care must be taken while using Biquad Cascade 32x64 filter function. Following issues must be considered:

Scaling of coefficients

Filter gain

Overflow and saturation

Filter coefficients are represented as fractional values and restricted to lie in the range [-1 +1). The processing function has an additional scaling parameter postShift which allows the filter coefficientsto exceed the range [+1 -1). At the output of the filter's accumulator is a shift register which shifts the result by postShift bits.

Fixed-point Biquad with shift by postShift bits after accumulator

 This essentially scales the filter coefficients by 2^postShift. For example, to realize the coefficients

   {1.5, -0.8, 1.2, 1.6, -0.9}

 set the Coefficient array to:

   {0.75, -0.4, 0.6, 0.8, -0.45}

 and set postShift=1

The second thing to keep in mind is the gain through the filter. The frequency response of a Biquad filter is a function of its coefficients. It is possible for the gain through the filter to


Wind power is considered one of the cleanest, most environmentally friendly energy sources presently available, and wind turbines have gained increased attention in this regard. A modern wind turbine typically includes a tower, a generator, a gearbox, a nacelle, and a rotor having a rotatable hub with one or more rotor blades. The rotor blades capture kinetic energy of wind using known airfoil principles. The rotor blades transmit the kinetic energy in the form of rotational energy so as to turn a shaft coupling the rotor blades to a gearbox, or if a gearbox is not used, directly to the generator. The generator then converts the mechanical energy to electrical energy that may be deployed to a utility grid.
The rotor blades generally include a suction side shell anda pressure side shell typically formed using molding processes that are bonded together at bond lines along the leading and trailing edges of the blade. Further, the pressure and suction shells are relatively lightweight and have structural properties (e.g., stiffness, buckling resistance and strength) which are not configured to withstand the bending moments and other loads exerted on the rotor blade during operation. Thus, to increase the stiffness, buckling resistance and strength of the rotor blade, the body shell is typically reinforced using one or more structural components (e.g. opposing spar caps with a shear web configured therebetween) that engage the inner pressure and suction side surfaces of the shell halves. The spar caps are typically constructed of various materials, including but not limited to glass fiber laminate


You are here

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INTRODUCTION {#s0}
============

After years of steady decline during the 1990s, syphilis, a sexually transmitted infection caused by the uncultivatable spirochete Treponema pallidum subsp. pallidum, has undergone a dramatic resurgence in the United States, particularly among men who have sex with men ([@B1]). Syphilis also poses a major threat globally, with an estimated 5.6 million new cases annually and 350,000 adverse pregnancy outcomes due to mother-to-child transmission ([@B2]). The failure of epidemiological approaches to curtail the spread of syphilis underscores the need for a vaccine capable of inducing protective antibody responses to geographically widespread and genetically diverse T. pallidum subsp. pallidum strains ([@B3], [@B4]). T. pallidum subsp. pallidum has been designated "the stealth pathogen" based on its ability to evade innate and adaptive immune responses for protracted periods, permitting repeated bouts ofhematogenous dissemination and invasion of numerous organs, including the central nervous system and the fetal-placental barrier during pregnancy ([@B5][@B6][@B7]). While the appearance of opsonic antibodies is widely regarded as a turning point in the battle between host and pathogen ([@B8], [@B9]), the targets of antibodies that promote bacterial clearance during syphilitic infection are largely unidentified. How immune pressures in high-risk populations influence the epidemiology of syphilis and the evolutionary biology of T. pallidum subsp. pallidum is also poorly understood.

Dual-membrane bacteria have evolved a unique class of integral outer membrane protein (OMP) in which antiparallel, amphipathic β-strands circularize to form a closed barrel structure, often creating a central aqueous channel that permits uptake of nutrients and efflux of waste products ([@B10][@B11][@B12]). Extracellular loops bridge adjacent transmembrane strands, extending from the


computational methods were employed to mine the T. pallidum subsp. pallidum Nichols strain genome for proteins predicted to form OM-associated β-barrels. This bioinformatics approach, combined with a battery of biophysical and cellular localization techniques, including opsonophagocytosis assays, yielded a panel of candidate OMPs ([@B33][@B34][@B37]). One of these, TP0326/BamA, is the central component of the molecular machine that chaperones newly exported precursor OMPs from the periplasm into the OM ([@B37], [@B38]). A homology model based on the solved structure of the Neisseria gonorrhoeae ortholog ([@B38]) predicts that the β-barrel of T. pallidum subsp. pallidum BamA contains 16 transmembrane β-strands and eight extracellular loops ([@B37]) ([Fig. 1](#fig1){ref-type="fig"}). One extracellular loop, L4, was previously shown by the use of human syphilitic serum samples to contain an immunodominant epitope; antibodies against this loop alsoOM, outer membrane; PG, peptidoglycan; CM, cytoplasmic membrane; L4, BamA immunodominant extracellular loop 4.](mbo0031839200001){#fig1}

Previously, Centurion-Lara and coworkers ([@B40]) performed a detailed analysis of *tpr* genes from four subspecies of pathogenic treponemes, including a small number of T. pallidum subsp. pallidum isolates. Their predictions regarding sequence variability and immune pressure, however, were based on structural models for TprC/D and TprI that used the full-length polypeptides rather than just the OM-embedded β-barrel-forming MOSP^C^ domains. Thus, no study to date has looked at sequence variation within the regions of T. pallidum subsp. pallidum OMPs known to reside at the host-pathogen interface (i.e., surface-exposed regions) in multiple T. pallidum subsp. pallidum strains circulating within at-risk populations. Here, we examined the β-barrel-encoding domains of the *tprC*, *tprD*, and *bamA* genes in DNA extracted from T. pallidum


exudative lesions were obtained from patients with early syphilis in San Francisco, CA (SF), and in Brno and Prague, Czech Republic (CZ). Specimens from Cali and SF were chosen for amplification and sequencing of β-barrel regions based on treponemal burdens determined by *polA* quantitative PCR (qPCR). The CZ specimens selected were PCR positive for all typing loci tested ([@B47]), reflecting high T. pallidum subsp. pallidum burdens. [Table S1](#tabS1){ref-type="supplementary-material"} in the supplemental material contains a summary of the available demographic information for the samples used in this study.

10.1128/mBio.01006-18.7

Summary of available geographic, clinical, and demographic data for clinical samples. Download TABLE S1, DOCX file, 0.02 MB.

Copyright © 2018 Kumar et al.

2018

Kumar et al.

This content is distributed under the terms of the

Creative Commons Attribution 4.0 International license

.

The T. pallidum subsp. pallidum strains in the clinical samplesal.

2018

Kumar et al.

This content is distributed under the terms of the

Creative Commons Attribution 4.0 International license

.

Nucleotide polymorphisms within *tp0558* (encoding a NiCoT family nickel-cobalt inner membrane permease \[[@B53]\]) also can be used for clade discrimination ([@B48], [@B54]). On the basis of the *tp0558* sequences, clade assignments for T. pallidum subsp. pallidum within 30 clinical samples were determined ([Fig. 2](#fig2){ref-type="fig"}). While the majority were exact matches for either clade at all five *tp0558* "discriminator" nucleotide positions, Cali_84, Cali_123, and Cali_133 contained substitutions not found in any of the T. pallidum subsp. pallidum reference strains. Of the 27 strains for which we also obtained partial *tp0548* sequences, all but one were concordant at both loci; Cali_133 was Nichols by *tp0548*, and SS14 by *tp0558*.

![Clade assignments of T. pallidum subsp. pallidum in clinical samples based


a proline in place of a serine at residue 491 in region I (L3/E1; [Fig. 3B](#fig3){ref-type="fig"}), thereby creating a novel E1 epitope. The remaining TprC β-barrel variants within the clinical samples were exact matches for either the Nichols or Sea81-4 allele. Notably, of the eight T. pallidum subsp. pallidum clinical strains assigned to the Nichols clade (indicated by carat symbols in [Fig. 3B](#fig3){ref-type="fig"}), only three contained a Nichols β-barrel variant, while all of the clinical strains assigned to the SS14 clade contained a Mexico A/PT_SIF β-barrel variant ([Table 1](#tab1){ref-type="table"}; see also [Fig. 3B](#fig3){ref-type="fig"}). Cali_133, the strain with discordant *tp0548* and *tp0558* sequences ([Fig. 1A](#fig1){ref-type="fig"} and [Fig. 2](#fig2){ref-type="fig"}, respectively), also contained a Mexico A/PT_SF β-barrel variant.

T. pallidum subsp. pallidum reference strains encode only two TprD β-barrel variants. {#s1.7}
-------------------------------------------------------------------------------------

Centurion-Lara and coworkers ([@B40], [@B60]) were the firsta 5-amino-acid deletion in the Mexico A allele ([Fig. 6A](#fig6){ref-type="fig"} and [B](#fig6){ref-type="fig"}). Region I contains a 49-nucleotide stretch unique to the SS14 allele. Region II consists of a single nucleotide change found only in the Mexico A allele. Region III also consists of a single nucleotide with a "G" in the Mexico A and SS14 alleles and a "T" in Nichols and Sea81-4 alleles. Region IV, the most polymorphic, consists of either a single nucleotide substitution along with a 15-nucleotide deletion unique to the Mexico A allele or nonidentical stretches of 15 nucleotides in the other three alleles; of note, substitutions in this region modify the polyserine tract ([Fig. 6A](#fig6){ref-type="fig"} and [B](#fig6){ref-type="fig"}; see also [Fig. S4](#figS4){ref-type="supplementary-material"}), a unique feature of BamA orthologs in pathogenic treponemes ([@B34], [@B61], [@B62]). Regions V and


pallidum reference genomes ([Table S2](#tabS2){ref-type="supplementary-material"}). Four of the six reference strains belonging to the Nichols clade (CDC A, Nichols, Chicago, and DAL-1) had Nichols *tprC*, *tprD*, and *bamA* alleles, while Sea81-4 and UW189B harbored *tprD2* in addition to Sea81-4 *tprC* and *bamA*. Although all members of the SS14 clade harbored *tprD2* alleles, variability at the other two loci, particularly *tprC*, was noted ([Table S2](#tabS2){ref-type="supplementary-material"}). Parsimony analysis ([@B63]) of the T. pallidum subsp. pallidum reference genomes confirmed that the three OMP loci were poor predictors of clade assignment. *tprC*, *tprD*, and *bamA* contained only 25.9%, 0%, and 5.6% parsimony informative sites, respectively, compared to 80.6% for *tp0548* and 100% for *tp0558*.

Sequences were obtained from all three OMP loci in five clinical strains assigned to the Nichols clade ([Tables 1](#tab1){ref-type="table"} and [2](#tab2){ref-type="table"}). Of these,explanations, which are not mutually exclusive, can be envisioned. One is that T. pallidum subsp. pallidum OMPs are subject to "uneven" immune pressure due to various microbiologic factors, such as low copy numbers and/or heterogeneous expression within spirochete populations ([@B33], [@B77]), and to variability of antibody responses in persons with different genetic backgrounds. A second possibility is that structural constraints counterbalance immunologic forces promoting loop diversity. The notion of the presence of favored loop sequences that protect the bacterium has been invoked to explain the preservation of sequence types of PorB, the dominant porin of Neisseria meningitidis, commonly associated with invasive disease in surveys of endemic and epidemic meningococcal strains ([@B18]).

The worldwide resurgence of syphilis has kindled a sense of urgency for vaccine development ([@B2], [@B4], [@B86]). To


obese with lean men (P = 0.002), and analyzing dependence between continuous body mass index (BMI) and genotype (P = 0.002). In agreement, systolic blood pressure tended to be lower in those homozygous for allele T, which was not explained by the BMI - genotype dependence. We found no association to obesity for the PYY Arg72Thr polymorphism, which is located nearby the essential carboxy terminal. A common and conserved variant of the PYY and NPY receptor Y2R is less prevalent among obese compared to among lean Swedish men. This suggests that the common Y2R variant is protective against obesity. Our findings further implicate Y2R in food intake regulation.History Of America Coin

looking forward to ever brighter chapters in our Nation’s history book. The 2017 American Liberty Gold Coin is the first in a series of 24-karat gold coins the United States Mint will issue biennially.

Coin: Coin, a piece of metal or, rarely, some other material (such as leather or porcelain) certified by a mark or marks upon it as being of a specific intrinsic or exchange value. The use of cast-metal pieces as a medium of exchange is very ancient and probably developed out of the use in commerce of

Many hold this as an affirmation of a Christian origin of the American republic. consider a brief history of the minted maxim: The first coins struck by the nascent United States did not bear the.

According to Arendt,


of America’s favorite turtles. Ramiro told Western Mass News that Kevin Eastman,

The regal beauty of purple mountain majesties can be yours to treasure forever. This exciting program features a great variety of products to add to your collection, including an America the Beautiful Quarters Proof Set™, America the Beautiful Quarters Silver Proof Set™, 100-coin America the Beautiful Quarters bags, America the Beautiful Quarters two-roll sets, and the America the.

Ilhan Omar, the Muslim-American freshman congresswoman from Minnesota who has. ovation from the hundred Young Democrats in.

This is confirmed in the Reynolds Family History from the 1970 reunion, which reads: “Joshua Cox undoubtedly was the first American to own the Joshua Coin, a good luck piece highly valued by the Cox.

Challenge coins are carried as a symbol of pride, teamworktwist of fate and timing, be exactly where he needed to be – the right time and place – to lead us through that painful journey. As I think about great leaders I know, I realize hey have

The ostensible reason for all of this is to assure moral clarity — that being the coin of the realm these days. a dozen black players in their 52-year history. Irving Berlin, the author of “God.

And this time, she is an African American woman. “Lady Liberty, as depicted in coinage throughout the years, is modeled after our society’s continued evolution. The Washington Post in a phone.

S.S. Central America Time Line The S.S. Central America carried the most talked about treasure in American history. A book about the ship and its fabulous


The province’s affordable housing program will fund the construction of 4,900 new mixed-income rental units in 42 communities across the province, the B.C. NDP government announced at a media conference November 13.

Each of the new rental buildings created under the program will include a mix of homes for varying income levels. This will include “deeply subsidized” rentals for seniors and those on fixed incomes, affordable rentals for low- to moderate-income workers such as those in the service industries, and affordable rentals for middle-income earners such as nurses, first responders and teachers.

The 4,900 homes will be built under the provincial government’s $1.9 billion Community Housing Fund, which aims to build a total of 14,000 affordable rental homes over 10 years. This in turn is part of the province’s 10-yearseniors.

A full list of the first set of approved affordable housing projects across B.C. can be found here.

Selina Robinson, Minister of Municipal Affairs and Housing, said, “People and businesses are struggling under the weight of the housing crisis in B.C. Through the Community Housing Fund, we are building housing so that growing families, aging seniors and low- to moderate-income individuals can afford homes in the communities they live and work in. These new homes will have life-changing impacts for people and communities right across the province.”


provide Ahrendts with more control over the company's important Apple Store business compared to Browett, who served as Apple’s SVP of Retail for nine months, Apple Insider reported.

“I am profoundly honored to join Apple in this newly created position next year, and very much look forward to working with the global teams to further enrich the consumer experience on and offline,” Ahrendts said in a statement. “I have always admired the innovation and impact Apple products and services have on people’s lives and hope in some small way I can help contribute to the company’s continued success and leadership in changing the world.”

According to AllThingsD, Ahrendts was part of a select group of people -- including executives from Coach, Nike, Starbucks and Disney -- who were considered topcandidates for the position.

“I am thrilled that Angela will be joining our team,” Cook said, in the statement. “She shares our values and our focus on innovation, and she places the same strong emphasis as we do on the customer experience. She has shown herself to be an extraordinary leader throughout her career and has a proven track record.”

Ahrendts, 53, has been CEO of Burberry since July 2006. From 1998 to 2006 she was executive vice president at Liz Claiborne Inc., and earlier in her career, she served as president of Donna Karan International.

In September, Apple and Burberry collaborated with the iPhone-maker giving the luxury retailer early access to the iPhone 5s to capture the company’s runway show in London.


when she was the frontrunner. And I think the fact that they never did borders on malpractice,” she said. “There was that time she had the momentum and had the ball, and the fact that they didn’t really fucked her.”

“ There was that time she had the momentum and had the ball, and the fact that they didn’t really fucked her. ”

None of these groups sat completely sat out the primary. Both Planned Parenthood and NARAL have committed to record election spending this year, pledging tens of millions of dollars to ad buys and canvassing in key states like Arizona, Colorado and North Carolina. Before making a formal endorsement, Emily’s List donated $250,000 each to super PACs for both Warren and Klobuchar. All three have pushed for morethroughout the race, will continue advising candidates on these issues behind the scenes.

The NARAL spokesperson, meanwhile, said the group was “focused like a laser on making sure Donald Trump is a one-term president because he is the single greatest threat to reproductive freedom we have seen in a long time.”

And while choosing who to endorse in a primary full of women was painful, Reynolds added, “I would certainly rather have more women running than making it easier for us.”

“It’s a good type of change that I suspect we’ll have to face more going forward,” she said. “I hope we’ll have to face it in every presidential year.”


  }
		}
	`
	for iter, test := range []struct {
		name       string
		userSpec   string
		lnURLCreds string
		shouldFail bool
	}{
		{"no user creds required and no user so binds to ACC1", "", "", false},
		{"no user creds required and pick user2 associated to ACC2", "", "user2:user2@", false},
		{"no user creds required and unknown user should fail", "", "unknown:user@", true},
		{"user creds required so binds to ACC1", "user: \"ln\"\npass: \"pwd\"", "ln:pwd@", false},
	} {
		t.Run(test.name, func(t *testing.T) {

			conf := createConfFile(t, []byte(fmt.Sprintf(template, test.userSpec)))
			defer os.Remove(conf)
			s1, o1 := RunServerWithConfig(conf)
			defer s1.Shutdown()

			// Create a sub on "foo" for account ACC1 (user user1), which is the one
			// bound to the accepted LN connection.
			ncACC1 := natsConnect(t, fmt.Sprintf("nats://user1:user1@%s:%d", o1.Host, o1.Port))
			defer ncACC1.Close()
			sub1 := natsSubSync(t, ncACC1, "foo")
			natsFlush(t, ncACC1)

			// Create a sub on "foo" for account ACC2 (user user2). This one should
			// not receive anyc.Shutdown()

	for i := 0; i < 2; i++ {
		select {
		case e := <-l.errCh:
			if !strings.Contains(e, "Loop detected") {
				t.Fatalf("Unexpected error: %q", e)
			}
		case <-time.After(200 * time.Millisecond):
			// We are likely to detect from each A and C servers,
			// but consider a failure if we did not receive any.
			if i == 0 {
				t.Fatalf("Should have detected loop")
			}
		}
	}

	// The reconnect attempt is set to 5ms, but the default loop delay
	// is 30 seconds, so we should not get any new error for that long.
	// Check if we are getting more errors..
	select {
	case e := <-l.errCh:
		t.Fatalf("Should not have gotten another error, got %q", e)
	case <-time.After(50 * time.Millisecond):
		// OK!
	}
}

func TestLeafNodeHubWithGateways(t *testing.T) {
	ao := DefaultOptions()
	ao.ServerName = "A"
	ao.LeafNode.Host = "127.0.0.1"
	ao.LeafNode.Port = -1
	a := RunServer(ao)
	defer a.Shutdown()

	ua, _ := url.Parse(fmt.Sprintf("nats://127.0.0.1:%d", ao.LeafNode.Port))

	bo := testDefaultOptionsForGateway("B")
	bo.ServerName = "B"
	bo.Accounts = []*Account{NewAccount("SYS")}
	bo.SystemAccount = "SYS"
	bo.LeafNode.ReconnectInterval = 5


oral antihyperglycaemic drugs (OADs) and/or basal insulin. The improvements in glycaemic control and reductions in body weight were stably maintained during long-term therapy (up to 3.5 years). The efficacy of adjunctive exenatide twice daily was generally similar to that of basal, prandial or biphasic insulin, sulfonylureas, rosiglitazone and lixisenatide, and less than that of liraglutide, taspoglutide or exenatide once weekly with respect to reductions in glycated haemoglobin. Exenatide twice daily was generally well tolerated; mild to moderate nausea and vomiting, which decreased with time on therapy, were the most common adverse events. In patients not receiving concomitant sulfonylureas or insulin, the incidence of hypoglycaemia was low; when it did occur, it was generally mild in severity. Thus, adjunctive exenatide twice daily is a valuable option in the treatmentSURPRISE, Ariz. -- Outfielder Joey Gallo is sidelined with a strained right groin muscle and the Rangers are unsure if he’ll be ready for Opening Day on March 28 against the Cubs. “Hard to say right now,” Rangers assistant general manager Shiraz Rehman said on Sunday. “We hope so…we’ll probably

SURPRISE, Ariz. -- Outfielder Joey Gallo is sidelined with a strained right groin muscle and the Rangers are unsure if he’ll be ready for Opening Day on March 28 against the Cubs.

“Hard to say right now,” Rangers assistant general manager Shiraz Rehman said on Sunday. “We hope so…we’ll probably know more at the end of the week."

Gallo felt the muscle while playing against the Royals on Thursday. It still bothered him on Friday, so the Rangers sent him for


    )

       Appeal from the District Court of the Sixth Judicial District, State of Idaho,
       Bannock County. Hon. David C. Nye, District Judge.

       Order denying motion for appointment of counsel, affirmed; order summarily
       dismissing petition for post-conviction relief, affirmed.

       Shaun P. Conley, Boise, pro se appellant.

       Hon. Lawrence G. Wasden, Attorney General; Lori A. Fleming, Deputy Attorney
       General, Boise, for respondent.
                 ________________________________________________

HUSKEY, Judge
    + 20, 2*p + 3*x = -1. Let r(u) = u - 6. Let t be r(6). Which is smaller: t or p?
t
Let k = -10/9 + -2/9. Let z(p) = -p**3 - 6*p**2 + 9*p + 8. Let j be z(-7). Let c = 4 + j. Does c = k?
False
Let o = 2/89 + -97/356. Let v = -0.252 - 1.768. Let q = -0.02 - v. Which is bigger: o or q?
q
Suppose 2*k - 3 = k. Suppose 2*s = k*s. Do 0 and s have different values?
False
Let t = 32 - 30. Which is smaller: t or -0.09?
-0.09
Suppose -3*z + 29 = 3*o - 8*z, 4*o = -4*z - 4. Suppose -l - o*l = -32. Suppose -4*s = l, 4*b = 2*s -


= -4*f - 21, 0 = -3*f + y - r. Is -6 at least as big as f?
True
Let i(v) = -v**3 - v**2 + 6*v - 1. Let s be i(-3). Let x be (-1)/(-4) - (-47)/4. Suppose -4*h - d = 0, 3*h - x = 4*d + 7. Which is bigger: s or h?
h
Let g = 728 + -91711/126. Let y = 2/63 + g. Which is greater: y or 1/3?
1/3
Let v(b) = -3*b**2 + 4*b**3 - 4 - 3*b**3 + 0 - 3*b + 0*b**2. Let j be v(4). Let c = -2 + 1. Which is smaller: j or c?
c
Let c = -381/4 + 96. Are -1/2 and c equal?
False
Let f = -14 - 1. Is f < -14?
True
Let f(l) = -l**2 -Cookies

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Many now prefer therapy apps to visiting their GP - here's why

09 January 2018

Apps are attractive to individuals worried their GPs won't be able to refer them for talking therapies, Mental Health Today explained in a Sky debate.

Therapy apps have a role to play in mental health for individuals who feel isolated and are worried their GPs may not refer them for talking therapies, Mental Health Today explained during a debate for international news channel TRT World.

"More people are


intimidating in itself, due to stigma that hasn't quite gone away.

"Realistically, there is still stigma, it's still there. I've got family members who've been through trauma that have wanted to get time off work to get access to support, but that request in itself can be very intimidating if you're already going through a lot."

Mental Health Today gives a direct voice to people with mental health needs and shares innovative ideas that drive progress in care.

Barney was joined on the panel by the founder of online counselling platform XenZone, Elaine Bousfield, along with author and psychotherapist Aaron Ballick, and academic Andre Tomlin.

Show your support for what you’ve read today. Enable us to keep finding and sharing the ideas that will better shape tomorrow’s mental health care.be the normalization and $\{P_i,Q_i\}$ $(1\leq i \leq 4)$ the inverse images of the four nodes on $C$. Since the curve $\tilde{C}$ is genus 2, there is a rational function $f_n$ on $\tilde{C}$ such that $\Div(f_n)\equiv\sum_{i=1}^4 r_i(P_i-Q_i)$ mod $p^n$ (this is a simple application of the theorem of Mattuck [@mattuck] which asserts that the Jacobian $J(\tilde{C})(\Q_p)$ is isomorphic to $\Z_p^2$ modulo finite groups). Thus the pair $(C,f_n)$ determines an element in $\CH^2(X,1;\Z/p^n\Z)$. We then prove that its boundary is nontrivial (hence indecomposable) under some assumptions.

This paper is organized as follows. In §\[nodesect\], we give an axiomatic approach to the construction of surface with infinite $p$-primary torsion in the Chow group of $0$-cycles. In §\[quinticsect\], we will construct such a quintic surface over $\Q_p$. A technical difficulty appears in


H^{0,2} \ot \Omega^2_S$$ $$\label{sym3}
    0\lra
    H^{2,0}\ot \Omega^1_S\lra
    H^{1,1} \ot \Omega^2_S$$ induced from the Gauss-Manin connection are exact at the middle terms. Here we put $H^{i,j}
    =(R^jf_*\Omega^i_{X_S/S})_{\mathrm{prim}}$ the Hodge $(i,j)$-component of the primitive cohomology $H^2_\dR(X_S/S)_{\mathrm{prim}}:=H^2_\dR(X_S/S)/[H]$ with $H$ a hyperplane section.

(B)

:   $C_R$ satisfies the following conditions [**(B-1)**]{} and [**(B-2)**]{}.

(B-1)

:   1.  $C_R$ is an irreducible (hence integral) scheme (cf. Remark \[reduced12\]).

    2.  $C_K$ has singular points $A_1,\cdots,A_m$ which are $K$-rational nodes.

    3.  $\pi^{-1}(A_i)$ consists of two $K$-rational points $P_i$ and $Q_i$.

    4.  $C_{\F}$ is not irreducible (hence so is neither $\tilde{C}_{\F}$ nor $C'_\F$, cf. Remark \[irred11\]).

(B-2)

:   There are $r_i\in \Z_p$be as in [**(vi)**]{}. We may assume that holds by exchanging $P^\sigma_{i,\Z_p}$ and $Q^\sigma_{i,\Z_p}$ if necessary. Then $\AJ(P^\sigma_{i_1,\Q_p}-Q^\sigma_{i_1,\Q_p})-\AJ(P^\sigma_{i_3,\Q_p}-P^\sigma_{i_3,\Q_p})$ and $\AJ(P^\sigma_{i_2,\Q_p}-Q^\sigma_{i_2,\Q_p})-\AJ(P^\sigma_{i_3,\Q_p}-P^\sigma_{i_3,\Q_p})$ are linearly independent over $\Q_p$ in $J^\sigma(\Q_p)\ot\Q\cong\Q_p^2$.

\[exists\] There exists $\sigma$ which satisfies all of the conditions [**(i)**]{},$\cdots$,[**(vi)**]{}.

We shall give a proof of Proposition \[exists\] in §\[existssect\].

\[exists1\] Suppose that $\sigma$ satisfies all of the conditions [**(i)**]{},$\cdots$,[**(vi)**]{}. Then $(X_{\Z_p},C_{\Z_p})=(X_{\Z_p}^\sigma,C_{\Z_p}^\sigma)$ satisfies the condition [**(B)**]{}.

[**(B-1)**]{} is straightforward. We see [**(B-2)**]{}. Since $J$ is a 2-dimensional abelian variety over $\Q_p$, one has $$J^\sigma(\Q_p)\cong \Z_p^2+\mbox{(finite group)}$$ by the theorem of Mattuck [@mattuck] (see also [@serre] Part II Ch.V §7, Corollary 4). Therefore there is a nontrivial relation $$\label{mattuck}
\sum_{k=1}^3 r_k\AJ(P^\sigma_{i_k,\Q_p}-Q^\sigma_{i_k,\Q_p})=0\quad \mbox{in } \plim n J^\sigma(\Q_p)/p^n
\quad (r_i\in \Z_p)$$ which gives the condition [**(B-2)**]{} (1). We show that $r_1$, $r_2$ and $r_3$ satisfy [**(B-2)**]{} (2). Since $\tilde{C}^\sigma_{\Z_p}$


honor to that. I’ve just been enamored with the space. The potential for exploration is just amazing.”

As a professional artist, Xeno, 36, said she is always thinking about the ever-changing nature of her craft and the potential role that technology plays, or could play, in that evolution. In particular, laser cutting and vinyl cutting are causing Xeno to think about expanding in art in different directions than previously considered, especially with respect to apparel and textiles.

“I think my work has evolved and changed, and new technologies have informed it or given me alternatives that I wouldn’t have really thought of before,” Xeno said, in reflecting on how the Maker-in-Residence time has influenced her work. “It’s changed everything. It’s changed the way I see things on a day-to-day basis.

“Havingcomes from phase space regions which are systematically and theoretically under control. In this paper we extend this approach to test two signal hypotheses, with the technical complication that over phase space the expected ratio of events can lie on either side of unity.

In general, the likelihood of observing $n$ events assuming a hypothesis $H_0$ is given by the Poisson distribution $\text{Pois}(n|n_0)=e^{-n_0} \, n_0^n/n!$. We can generalize this counting experiment by introducing a observable $x$, where we assume that $H_0$ is described by the normalized distribution $f_0(x)$. Similarly, the alternative hypothesis $H_1$ is described by $f_1(x)$. Each likelihood can be factorized into the Poisson likelihood to observe an event and the normalized event likelihood $f_{0,1}(x)$. In combination they give the single-event log-likelihood ratio (LLR) $$\begin{aligned}
q_{n=1}(x) &= \log \;


from Monte Carlo simulations, we can compute the above LLR. A very simple structure containing only the last term appears, when we only rely on kinematic distributions and not on the total rate. We can generalize Eq. to the likelihood of observing $n$ events in a phase space configuration $\vec
x=\{x_j\}$. The normalized event likelihood is now a product of $n$ likelihoods at the corresponding configurations, so we find $$\begin{aligned}
q_n(\vec x) &= \log \; \frac{L(\vec x|H_1)}{L(\vec x|H_0)}
      = \log \; \frac{\text{Pois}(n|n_1)    \; \prod_{j=1}^n f_1(x_j)}
                     {\text{Pois}(n|n_0)  \; \prod_{j=1}^n f_0(x_j)}  \notag \\
%     &= \log \left[ \frac{e^{-n_1}}{e^{-n_0}} \;the crucial QCD jet activity in the signal and background events.

For the two $b$-quarks and two photons in the final state we need to simulate the detector performance. We use a $p_T$-dependent and $\eta$-dependent $b$-tagging rate with $\epsilon_b \approx 0.7$ at high $p_T>100$ GeV in the barrel, respectively. Towards larger $p_T$ the $b$-tagging efficiency will be reduced. For our choice of efficiencies the $jj\gamma\gamma$ background ($j=u,d,s,g$) is negligible. If instead we choose a constant $b$-tagging efficiency and a $p_T$-dependent misidentification rate the light-flavor backgrounds in the low-$p_T$ regime increase significantly. Similarly, the photon identification efficiency and fake rate due to jets depends on the barrel versus end-cap position, the transverse momentum, and the parton forming the jet. All tagging efficiencies used in this analysis are described in Appendix \[app:sim\].

To simulate


in Fig. \[fig:coup\_s\]. As a result, the significance peak in the SM background rejection around $m_{HH} = 450$ GeV moves to slightly below 400 GeV when we are interested in $\lambda$. Similarly, the background-driven significance at $p_{T,H} > 180$ GeV and the self-coupling-sensitive region $p_{T,H} < 150$ GeV together give a distinct peak at 150 GeV for $\lambda / \lambda_\text{SM} = 0$ or $\lambda / \lambda_\text{SM} = 2$. In contrast, for a very large self-coupling $\lambda / \lambda_\text{SM} = 5$ the significance receives contributions from two distinct regions of phase space, $p_{T,H} \approx 50$ GeV and $p_{T,H} \approx 220$ GeV. The geometric separation of the two photons and the transverse momentum of the harder $b$-jet follow the same pattern. This means that the most significant phase space regions for a measurement of the self-coupling are drivenexpect our results to also hold for other channels with large continuum backgrounds. The two relevant phase space regions for the signal extraction and the coupling measurement are separate and in particular for the signal extraction well understood in terms of systematic and theoretical errors.

The most sensitive phase space region for extracting the self-coupling is close to threshold, where we expect the QCD background to overwhelm the Higgs pair signal. The main question will be how well we understand those backgrounds and how much of this region can still be used for the self-coupling measurement. Assuming SM-like self-coupling, the bulk of the coupling-sensitive region in the presence of QCD backgrounds is only slightly softer than the relevant phase space for the extraction of the Standard Model signal. For


Speaking at the White House Wednesday to follow up on President Donald Trump's surprise announcement that he would order the military to help secure the southern border, Homeland Security Secretary Kirstjen Nielsen refused to detail the size, scope or cost of a planned deployment of National Guard troops, but said it was hoped they could be deployed "immediately" – as early as Wednesday night.

Wednesday evening, a senior administration official said the president had signed a proclamation authorizing the National Guard to assist the border patrol.

Trump wants to send the U.S. military to protect the border with Mexico while the new border wall he wants is built and Nielsen also said the administration was "looking into options for the military to build a wall" on military installations on thewere on something else though, "I was right. How long have your nipples been this hard little sis?" When Ruby didn't answer from sheer embarrassment, Yang clicked her tongue before speaking again.

Her arms snaked back to their original positions, "How long have you been itching for this Ruby? How long have you wanted your older sister to violate your body?" Hearing her older sister speak in such a naughty way drove Ruby's brain into overdrive before shutting down finally. As Rose stared down at Yang's arm snake closer to the hem of her pants, her mind finally snapped.

"Just hurry..." Ruby whispered quietly, clenching her fists.

Yang just started humming, "Hm...?" She asked, her left hand already reaching Ruby's breasts and was massaging it while her right hand lingered at


Ruby's stomach, tracing circles around her belly button. Ruby had had it, she needed it. She wanted her sister's touch.

"Just take me..." Ruby whispered embarrassingly snapping her eyes shut again.

Yang gave a mild, humorous chuckle, before complying, "As you wish my little devil." And with that Yang in almost record time slithered her hand down Ruby's pants and underwear, and felt the fuzz brush against her fingertips.

"Keeping up with your trimming Ruby? That's sweet." Yang commented offhandedly before moving her middle finger up against her younger sister's clit. Ruby felt a large clump of air push itself into her throat and gulped painfully. That painful gulp became the last thing on her mind and was replaced with a sheer sense of pleasure from two sources. One was thatthe bone marrow and respond to growth factors and cytokines that are released into the circulation by injured endothelium and tissues or tumour tissues [@pone.0079658-Schatteman1], [@pone.0079658-Patenaude1]. The BM compartment activation results in the EPCs mobilization and recruitment to the tumour bed where they take part to the formation of neovasculature and tumor growth in adults [@pone.0079658-Schatteman1], [@pone.0079658-Patenaude1].

The formation of blood vessels occurs by two mechanisms: vasculogenesis and angiogenesis. Vasculogenesis is the process where blood vessels are formed de novo by in situ differentiation of angioblasts into mature EC [@pone.0079658-Schatteman1], [@pone.0079658-Patenaude1]. In contrast, angiogenesis occurs both during embryonic development and postnatal life and is defined as a process that gives rise to new blood vessels by proliferation and migration of pre-existing differentiated EC [@pone.0079658-Schatteman1], [@pone.0079658-Patenaude1]. It has been also


western blot assay for the expression of the total Bcl2 and Beclin-1 proteins and immunoprecipitation of Bcl-2 and Beclin-1 subsequently blotted with either anti-Beclin-1 or Bcl-2 antibodies, respectively, for the evaluation of Bcl-2/Beclin-1 and Beclin-1/Bcl-2 complex formation as described in "Material and Methods". Untreated cells, CTR; CLC added for 72 h, CLC 72 h; RAD added for 48 h, RAD 48 h; CLC added for 72 h and RAD for the last 48 h, CLC → RAD. The figure is representative of three different experiments that always gave similar results. B) Representation of the Bcl2/Beclin-1 complexes expressed as the ratio between the relative intensities of the bands associated with the Bcl-2/Beclin-1 and Beclin-1/Bcl-2 complexes versus the bands associated with total Bcl-2 and Beclin-1, respectively. The intensities of thesame time, induces a slight decrease of the Erk-1/2 activity and increases Akt activity. On these bases, the addition of CLC before RAD to EPCs inhibits autophagy occurrence through association of beclin-1 to bcl-2 and has poor effects on apoptosis as it decreases the activity of the pro-survival Erk-1/2, but increases the activity of the anti-apoptotic Akt. The subsequent addition of RAD potentiates the pro-apoptotic effects of CLC as it enhances the inhibition of Erk-1/2 and inhibits, at downstream levels, the Akt-dependent signalling (activated by CLC). In this way, the sequential treatment with the two agents induces a potent switch from autophagy to apoptosis in EPCs.](pone.0079658.g008){#pone-0079658-g008}

[^1]: **Competing Interests:**The authors have declared that no competing interests exist.

[^2]: Conceived and designed the experiments: MLB DS MC FP. Performed the experiments:


0;

    setInterval(function(){
    lastx = posx;
    lasty = posy;

    posx = Math.floor((Math.random()*100)+1);
    posy = Math.floor((Math.random()*100)+1);

        $('#square').animate({ left:(posx*1), top: (posy*1) }, 3000, function() {
        ctx.beginPath();
ctx.moveTo(lastx,lasty);
ctx.lineTo(posx,posy);
ctx.stroke();

        });

},3000);
});

Hope it helps!

to instantiate a virtual team environment that provides knowledge of the availability of other team members to facilitate communications attempts. It also fails to facilitate voice or multimedia communications among team members.
There therefore exists a need for a tool that facilitates collaboration among geographically-dispersed members of a team by creating a virtual team environment that provides dynamic preference and presence information to permit communications sessions among team members to be transparently established.


governments fear people, there is liberty. When the people fear the government, there is tyranny. Thomas Jefferson

I usually boot once, maybe twice a day. I mostly select sleep if I'm away from the PC. I will wait and see if/when Secunia PSI warns me that it needs to be patched. If the Automatic updates haven't worked by then I will do it manually from then on. It's no big deal as I visit dslreports every day and Adobe updates are always mentioned if a new version is out. It would just be nice that the Automatic feature would update the same day a patch is released, rather than a few days down the line.Q:

Circular determinant problem

I'm stuck in this question:
How calculate this determinant ?
$$\Delta=\left|\begin{array}{cccccc}
1&2&3&\cdots&\cdots&n\\
n&1&2&\cdots&\cdots& n-1\\
n-1&n&1&\cdots&\cdots&n-2\\
\vdots &\ddots & \ddots&\ddots&&\vdots\\
\vdots &\ddots & \ddots&\ddots&\ddots&\vdots\\
2&3&4&\cdots&\cdots&1
\end{array}\right|$$
Thanks a lot.

A:

Since the matrix with determinant $\Delta$ is circulant, its eigenvalues $\{\lambda_j\}_{j=1}^n$ are given by
$$\lambda_j=1+2\omega_j+3\omega_j^2+\ldots+n\omega_j^{n-1},$$
where $\omega_j=\exp\left(\frac{2\pi ij}{n}\right)$. The determinant is the product of the eigenvalues.
For an explicit formula not involving products and sums, see sequence A052182 in OEIS. It can be shown that
$$\Delta(n)=(-1)^{n-1} \cdot n^{n-2} \cdot \frac{n^2+n}{2}$$


another chart showing the Clinton’s foreign contributions from countries like Saudi Arabia, Morocco, Algeria, and Qatar.

Trump has more charts and visual aids in Kissimmee tonight. pic.twitter.com/jJp63KJfzz — Nick Timiraos (@NickTimiraos) August 11, 2016

Another chart demonstrated contributions from hedge funds, exposing Clinton as having received more than $48 million in donations from hedge funds, while Trump has only received $19,000.

“They used a terrible picture of Hillary and I said, ‘No way you’re going to do that — that’s no fair,’” Trump added about one card, saying it now has a “beautiful picture of Hillary.”

“Are we liking these cards? Isn’t this great,” he added. “It’s different.”

Trump spent all day Thursday campaigning in Florida, where he spoke in Miami to the National Associations of Home Builders in the morning and thenlevels, they held below freezing for extended periods of time, ranging from zero hours in central Kansas to as many as 21 hours in Wallace County during the April 29 – 30 period, and 24 hours in Tribune during the April 29 to May 01 period (Fig. 3).

Wheat injury due to cold temperatures is more likely if it occurs repeatedly and if it is windy at night. Such conditions were experienced over the course of April 29 – May 1. During this period, we observed below-freezing temperatures three consecutive nights and wind speeds of more than 40 miles per hour for more than 6 consecutive hours, especially in southwest Kansas. The three consecutive nights with below-freezing temperature reduces the chances that wheat can escape freeze injury by having


tillers that emerged at different times or wheat flowers within the same head pollinating at different times.

Figure 2. Minimum temperatures during the mornings of April 30 (upper panel) and May 1 (lower panel), 2017. Source: Weather Data Library (mesonet.ksu.edu/freeze).

Figure 3. Length of time below 32 degrees Fahrenheit during the 24-hour period encompassing the morning of April 30 (upper panel) and May 1 (lower panel), 2017. Source: Weather Data Library (mesonet.ksu.edu/freeze).

Possible consequences to the wheat crop

A cold spell during the spring often reduces wheat yield potential due to the direct damage from cold air temperatures. At earlier stages of wheat development, when a minimum of 2-3 inches of snowfall is present and entirely covers the wheat crop, it is often positive as it buffers cold damaged from temperatures lower(Fig. 5), causing another source of yield loss in addition to the cold temperatures.

Figure 4. Wheat field in western Kansas almost completely covered by snow during the morning of April 29, 2017. Photo by Justin Gilpin, Kansas Wheat.

While yield loss from this snowfall event might occur in most of the fields affected, the magnitude of the yield loss at this point is uncertain. At least one week to 10 days will be needed to properly assess the situation, after the snow melts away. The yield loss will depend on stage of crop development, severity of stem breaking, and number of hours of below-freezing temperatures observed.

Yield losses due to stem breaking are generally lower if the crop is at boot stage (when it still has time to compensate with


Plumas Arts and Plumas County Library welcome California State Poet Laureate Dana Gioia to Plumas County

Plumas Arts, together with the Plumas County Library, presents a poetry reading and a conversation with Dana Gioia, California’s state Poet Laureate, on Monday, April 3, at 4:30pm at the Quincy Branch of the Plumas County Library. Gioia, as part of his mission to visit every county in the state while holding the title of Poet Laureate, has been making extended trips throughout California to promote interest and participation in poetry.

Appointed by Governor Jerry Brown in December, 2015, Gioia serves as the state advocate for poetry and literature in libraries, classrooms and boardrooms across California. An award-winning poet, Gioia is the author of Can Poetry Matter?, which is credited for helping revive poetry’sQ:

Run bash scripts from python. MAC OS

I am trying to run scripts for python in MAC OS.
I was unable to run scripts that run Bash.sh scripts, any one here have an idea about how can I run bash.sh From python in Mac OS.
Thanks you for any help :)!
(This is the scripts:
Called: RunScript.sh, and I need to run it from Python Script.)

A:

Does os.system not work?
import os
os.system("/path/to/script.sh")


10-K, a publicly disclosed annual report filed with the Securities and

Exchange Commission (“SEC”). Appellants further allege that DTTC is liable under § 18 of the

Exchange Act for filing its allegedly misleading audit opinions with the SEC and that appellee

Deloitte & Touche LLP (“D&T”), DTTC’s United States affiliate, both violated § 18 by causing

DTTC to file the audit opinions and is liable as a “control person” under § 20(a) for DTTC’s

violations. We assume the parties’ familiarity with the facts, procedural history, and issues

presented for review.

   I.       Standard of Review

         Because the district court denied appellants’ motion for leave to amend as futile, we

review de novo the sufficiency of the allegations in appellants’ proposed                                    4
of negligence or allegations that a better audit would have uncovered the fraud earlier will not

suffice. See Advanced Battery, 781 F.3d at 644.

       Here, in support of their argument that DTTC acted with scienter, appellants identify a

number of alleged “red flags” indicative of fraud that they contend DTTC recklessly disregarded.

We agree with the district court that appellants’ allegations fall short of showing scienter under

the PSLRA.

       The majority of appellants’ allegations related to the purported red flags can be grouped

into two