buffers. As he said, this may be suggestive but is not quite conclusive.

Dr. Fast graciously provided me the data that went into his buffers and I re-ran his chi-square calculations to make sure I could replicate his results. Initially I thought the non-significance of the < 1 km buffer (you’d expect the buffer closest to the turbines to show the most significant effect) was due to the income-producing nature of any land close to a wind turbine, plus the setback that rendered about 25% of that buffer unoccupied. While those could be important, I also noticed that by chance there were a lot of reductions just outside of the 1 km border. As an example I show the following picture of the reductions around Wolfe’s main city, Marysville:

Theto obtain the answer your sponsor wants. Instead of providing us the prices and letting us judge for ourselves what any effects might be, they opaquely run those prices through their regressions and voila! claim there’s nothing to see here!

But whoever wrote Part 2 must not have been talking to whoever wrote Part 1. On page 18, well within part 1, there’s Figure 2. It’s purpose there is to show how close the appraisals are to the sales data (the paired blue and green bars) for the different distances from the IWTs.

Note the blindingly obvious. Prices (and appraisals) within 5 km of IWTs are substantially lower than those further away. I’ve added the horizontal lines so we can better determine the values, which are noted to the side.


of this part of the study (and the study as a whole) seems to be to publicize MPAC’s skills at keeping the assessments in line with reality, and at the same time deflect how MPAC is going about doing this. MPAC is, after all, in a tight spot. The reality is that home prices take a dive when close to IWTs. MPAC somehow has to lower the assessments around IWTs to keep the ASRs in line while keeping their bosses happy.

Unfortunately, the wind industry will be using this study for quite a different purpose – to bolster their argument that IWTs don’t impact home prices in the first place.

If you haven’t already please read the summary posting as an introduction. This is the third of four postings ontechniques like multiple regression analysis to obtain their estimates. The second class tends to think in terms of rejecting the null hypothesis – you assume there is no difference between two sets (in this case close-in prices and far-away prices) unless you have “statistical significance”. As a snarky aside, getting to statistical significance in real estate can be quite a challenge, given the wide variance among prices, and can be even more difficult when your sponsor/boss doesn’t want you to do so.

So of course MPAC used their main tool, regression equations that run multiple regression analyses. They created three new variables based on distance from an IWT and entered these into regression equations to see if the new variables were statistically significant. If they aren’t statistically significant they


noise and weather-measuring equipment to his home. Whenever the noise bothered him, he could press a button and a 10-minute detailed recording period would start. During the 7+ days the equipment was in place he pressed the button 9 times. The MOE ran off and after a while dutifully reported back that the operator was substantially in compliance. Libby released that report to the public back in January 2012, which got a posting on Ontario Wind Resistance. John Harrison then took a look at it, and now we can see just how complicit the MOE is in harming people in order to protect this industry. Continue reading The MOE and Libby→

Humans have used models to describe and predict their environment for millennia. With the advent of computers the(-1)/8*w - 55/60. Which is the nearest to -0.2?  (a) 4  (b) y  (c) 5  (d) 3/8
b
Let m = 92 - 9. Let z = m - 83. Let q = -14.3 - -15. Which is the nearest to z?  (a) -4  (b) 2/15  (c) q
b
Suppose -2*z - 36 = 19*z - 30*z. Which is the nearest to 3?  (a) -28  (b) 3  (c) -3  (d) z
b
Let o = 381 + -241. Let p = o + -139. Let c = 0.2 - 0.1. What is the closest to c in p, 3, 0.5?
0.5
Let s = 415.2 + -415.12. Which is the nearest to 0?  (a) -0.5  (b) s  (c) -8  (d) -1
b
Let


h = 98.8 + -99. Let m = -643/204 - 1/68. What is the closest to h in 3, 1, m?
1
Let v(o) = -10*o - 183. Let r be v(-18). Suppose 7*f + 22 + 209 = 0. Which is the nearest to f?  (a) 3  (b) -5/3  (c) r  (d) -4
d
Let p be 6/18 - 5/(-3). Let o = 297.2 - 297.5. What is the closest to 1 in 1/3, o, p?
1/3
Let o = 19 + -5. Let t = -69 - -69.27. Let i = t - 0.47. Which is the nearest to i?  (a) o  (b) 5  (c) -0.5
c
Let y = 1/158 + 311/790. Let r = -789 - -792. Which is the nearest to y?  (a)tissue and cytology samples from 24 patients with endometrial cancer registered in the Clinical Research of Cancer Gene Panel Analysis of Gynecologic Cancers study from January to August 2019 at Kagoshima University Hospital were used. The specimens included 2 mL of whole blood as a reference, FFPE tissues from 10 biopsied, 29 resected tissues (39 FFPE tissues in total), and 10 residual LBC samples of endometrial cytology. The tissues were fixed with phosphate-buffered neutral 10% formalin within 24 h and routinely processed for paraffin embedding, followed by sectioning for hematoxylin and eosin (H&E) staining. The FFPE blocks were stored in the dark at room temperature (25 ± 2 °C). The endometrial cytology samples were obtained using a specific device (Endocyte® sampler, Laboratoire CCD, Paris, France) \[[@CR17], [@CR18]\], and collected cells were fixed with


than the age of 20.

Results {#Sec11}
=======

DNA quality and quantity obtained from FFPE and LBC specimens {#Sec12}
-------------------------------------------------------------

The results of the pathological diagnosis, DNA quality, and input DNA for NGS of the 24 endometrial cancer cases are summarized in Table [2](#Tab2){ref-type="table"}. The storage period of FFPE and LBC specimens ranged from 2 weeks to 3 years. The tumor fraction of the FFPE sections ranged from 30 to 90%. In endometrial LBC specimens, estimated tumor cell count (T) subjected to NGS varied from 1500 to 140,000, and the tumor cell ratio varied from 27 to 95% (T/N + T). All of the genomic DNA extracted from the FFPE and LBC samples demonstrated high-quality and sufficient quantity for library construction and successful sequencing. Table 2Pathological and DNA sample information for NGS analysisCase no.Sample no.SamplesPathological diagnosisStorage timeDNA yieldis check the logs.

A:

Mayo's answer explained your issue well. This shows you how to accomplish what you wanted to do.

I want is to make the player to change position each 0.5 seconds.

Instead of calling the movement function every time in the FindDirections function, call it once then execute your code in a while loop. This should fix your issue. Just move StartCoroutine(movement()); from the FindDirections function to the Start function or somewhere that calls it once. Below is your new movement code.
IEnumerator movement()
{
    while (true)
    {
        player.localPosition += selectedDirection;

        FindDirections();

        yield return new WaitForSeconds(0.5f);
    }
}

The while loop


/*

  u8g_dev_t6963_240x128.c

  Tested with Varitronix MGLS240128TZ

  Universal 8bit Graphics Library

  Copyright (c) 2013, olikraus@gmail.com
  All rights reserved.

  Redistribution and use in source and binary forms, with or without modification,
  are permitted provided that the following conditions are met:

  * Redistributions of source code must retain the above copyright notice, this list
    of conditions and the following disclaimer.

  * Redistributions in binary form must reproduce the above copyright notice, this
    list of conditions and the following disclaimer in the documentation and/or other
    materials provided with the distribution.

  THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS ANDto the World Health Organization (WHO) and OECD. The KNHANES consisted of a health interview survey, a health examination survey, and a nutrition survey. The data collected by the Alcohol Use Disorders Identification Test (AUDIT) and EuroQol 5-Dimension (EQ-5D) test, both of which are international standardized instruments, were subjected to multiple regression analysis to investigate the relationship between alcohol consumption patterns and HRQOL in a nationally representative sample of South Korean men and women aged ≥40 years.

The period V KNHANES (2010--2012) used a rolling survey sampling method to select participants who were representative of the civilian, non-institutionalized population of South Korea. To ensure that the sample was nationally representative, primary sampling units were selected in stage 1, and divided into segments based on sex and population ratios in


                            1.24 (0.57--2.70)    1   **3.52 (1.59--7.81)** [\*](#t004fn004){ref-type="table-fn"}    1.09 (0.38--3.12)                                             1.49 (0.49--4.54)    1   1.21 (0.25--5.76)
                         Model 2   1.06 (0.50--2.24)                                             1.17 (0.53--2.56)    1   **3.08 (1.38--6.90)** [\*](#t004fn004){ref-type="table-fn"}    1.15 (0.39--3.39)                                             1.53 (0.49--4.74)    1   1.05 (0.20--5.44)


age quartile within a cultural context.

Consistent with previous studies \[[@pone.0119245.ref008],[@pone.0119245.ref009],[@pone.0119245.ref017]\] that found a relationship between harmful consumption of alcohol and the exacerbation of negative health-related behaviors, the percentages of current smokers and heavy drinkers in the current study were found to be highest in zone IV for both men and women. However, the percentage of women engaging in regular exercise was found to be highest in zone III, a finding that was different from what was anticipated. Given the results of previous studies \[[@pone.0119245.ref008],[@pone.0119245.ref009]\], it was expected that the participants with positive health-related behavior would have positive drinking patterns, such that the percentage of women engaging in regular exercise would be the highest in zone I. However, for both men and women, the mean BMI in zone Iwas found to be the lowest, which was consistent with the results of a previous study \[[@pone.0119245.ref030]\], which reported that higher alcohol intake was associated with greater total and central adiposity. In terms of chronic disease, the rates of all chronic diseases, excluding liver-related diseases associated with alcohol consumption, were found to be the highest in zone I and the lowest in zone IV, which was an unexpected finding. However, this finding may be explained by the fact that the prevalence of chronic diseases, including hypertension, osteoarthritis, diabetes, and cancer, generally increase exponentially with age \[[@pone.0119245.ref002],[@pone.0119245.ref021]\], and that the participants in zone I were significantly older than those in zone IV. Thus, this finding might be attributable to the results of the univariate analysis without adjusting the data


outside the Kremlin. Man’s first rocket to the
moon.

Narrator: Jim Archer. Joe’s partner. Another man caught in the frantic race for
the betterment of mankind. Progress. Jim Archer. Wounded parachuting on Korea. Jim
and Joe try to keep the desert road safe for travelers. Seven days a week.

Narrator: Joseph Javorsky. Respected scientist. Now a fiend. Prowling the
wastelands. A prehistoric beast in the nuclear age. Kill. Kill just to be
killing.

(Beast wanders off)

Narrator: The mouth of a cave over a thousand feet up over jagged cliffs. A man
murdered. A woman’s purse. Jim and Joe pick their way upward to the mouth of
the cave. One slip… and a thousand feet to nowhere.

(they discover the woman)

“Well, there’s the owner of the purse.”
“Yeah. Let’s take her down. Might still be alive.”
“Yeah, she’s still breathing. Careful withQ:

BATCH - Replacing spaces in filename with %20 for curl

for /f %%n IN (new.txt) DO IF NOT EXIST "%current%\%%n" (
  ping -n 1 127.0.0.1 >nul
  setLocal EnableDelayedExpansion
  set n=1n: =%%20!
  curl.exe --globoff -o "%current%\%%n" ""http://someserver.com/%%n ""
  ping -n 3 127.0.0.1 >nul
)

I want to replace all spaces in %%n before handing it to curl to form a url to download the file specified in new.txt. I tried wrapping in double quotes and various other solutions to replace spaces, but none seem to have any effect. curl still doesnt form a proper url and cuts filenames before spaces.

A:

for /f "delims=" %%n IN (new.txt) DO IF NOT EXIST "%current%\%%n" (
    set "n=%%n"
    setLocal EnableDelayedExpansion
    set "n=!n: =%%20!"


the reflected light.

The "telephone poles" allow the energy to move efficiently across the device by preventing it from buckling or sagging. The design makes it easy to read the resonant frequency of the cantilever.

In this process, the researchers discovered that over short distances, the energy from the laser came in the form of heat, which quickly dissipates. But when the laser was parked hundreds of microns away from the cantilever, the energy came in the form of acoustical waves that traveled through the device, dissipated more slowly, and allowed them to make their device longer.

The research was the result of a collaboration with Slava Krylov of Tel Aviv University. The work was supported by the Defense Advanced Research Projects Agency; the Nanobiotechnology Center, which is funded by theconvention of Euler angles.
If you're working with a Z-X'-Z'' convention, then the only subtlety involved is to line up the $y$-axis with the first rotation instead.  This should correspond to a rotation about the $z$-axis by $\phi - \pi/2$ as your first rotation.


her multitasking secrets.

What made you pursue design?

IMAGE Studio Mara; bedroom interior

“I’ve always thought that I’d pursue a business program coming from a family of entrepreneurs. When I failed to make the cut and was given a slot in Interior Design [at University of the Philippines-Diliman], it made me think how exciting it could be to choose a different path—the creative life.”

ADVERTISEMENT - CONTINUE READING BELOW

You wear many hats: interior designer, production designer, prop stylist—how do you juggle all three?

IMAGE Jeanne Young; Set design for Preview, September 2015

“Interior design projects take longer to complete so that gives me enough time to do quick production design projects simultaneously. Since they’re all similar in nature, I treat them the same and just prioritize the tasks that need to be done.”

You’ve done                       Super. Ct. No. 51816487)

        Eugene Jones has filed a petition for writ of habeas corpus challenging the denial
of his superior court petition to recall his sentence and resentence him pursuant to Penal
Code section 1170, subdivision (d)(2) (section 1170(d)(2)).1 Jones is serving a sentence
of life in prison without the possibility of parole (LWOP) for a 1994 murder and other
offenses he committed when he was 19 years old. He contends that section 1170(d)(2)
violates his constitutional rights to equal protection of the law because it does not apply
to youthful offenders like him, who were between the ages of 18 and 25


543 U.S. at pp. 569–570.)
“Because juveniles have diminished culpability and greater prospects for reform . . . ‘they
are less deserving of the most severe punishments.’ ” (Miller, supra, 567 U.S. at p. 471.)
       Disputing this conclusion, Jones posits that the criteria for distinguishing juveniles
from adults supports his equal protection claim. According to Jones, the “underlying
rationale” of section 1170(d)(2) is that “young people are different developmentally and
neurologically” from older offenders. He further alleges that young adults who are
between 18 and 25 when they commit their LWOP offenses are similarly situated to
juvenile LWOP offenders because they also have developing brains, lack maturity, and
have increased potential for rehabilitation.
       Jones cites no authority for the purpose he ascribes to sectionto flanges of adjacent panels. Once assembly of the inside-out casing is nearly complete, the casing is turned right-side-out, and the final unclosed portions of the casing are joined to complete closure of the casing. For example, in some cases, one or two seams of a casing are left unclosed, providing an opening for the casing to be turned right-side-out through. Once the casing is turned right-side-out, a bladder, restriction layer, and/or other layers may be inserted through the opening before the last seams are joined, providing the final closure of the casing.


action plan would ensure those under the age of 45 living in aged care would find appropriate housing by 2022, and those under the age of 65 found appropriate housing by 2025.

Ms Morkham said while the plan was welcomed, there was still no indication about how it would actually be carried out.

"We've yet to see an implementation strategy," she said.

For young people in nursing homes with NDIS plans, there is no indication of how the plan will boost personal care in aged care residences where staff often don't have the training or the time to care for people with disabilities.

"There's still no clear vision for how that will happen through the action plan," Ms Morkham said.

'I'll keep fighting'

After years of lobbying by her sister-in-law, Angelina is one ofthe tax lien notice is filed. "Before 1966, the requirement of choateness ... generally operated to prevent a nonfederal lien from gaining priority over a federal tax lien with respect to property acquired by the debtor after the tax lien had arisen, even though the nonfederal lien antedated the tax lien."[7] In an effort to mitigate the traditional doctrine of choateness, under which security interests would be inchoate either if the loan had not been disbursed or if the collateral had not come into existence by the time the tax lien was noticed, a 45-day safe harbor period was added to the tax code. The underlying purpose of the statute as relevant to this case is straightforward: protection is given the financier "only where the loan or purchase


by the taxpayer before the lien priority date.[11] The term "commercial financing security" is defined by statute as including four types of property: paper of a kind ordinarily arising in commercial transactions (including paper giving contract rights[12]); accounts receivable; real property mortgages; and inventory.[13] As relevant to that part of the Internal Revenue Code, a "contract right" is "any right to payment under a contract not yet earned by performance and not evidenced by an instrument or chattel paper."[14]
Applying these rules to the case before it, the court must determine whose security interest in the Disputed Cash has priority. As required by § 6323(c), to have priority over the government's tax lien AIF must demonstrate that (1) the security agreements were entered into before the tax lien filing;28, 2002.
Even if the court were to rule contrary to the statute's direction that the new version of the Utah UCC be retroactively applied, the outcome would be the same. If the court were to find that AIF's security interest included "contract rights," and that the recently added category of "health-care-insurance receivables" is inapplicable, it still would find for the government because those contract rights did not extend to the proceeds resulting in the Disputed Cash. The Disputed Cash was the fruit of Nightime's performed services and did not result from the Provider Contracts. While the court does not dispute AIF's argument that Nightime had certain contract rights under the Provider Contracts, such rights were limited and did not extend to the funds resulting in the Disputed Cash.


It's a danger zone on Wall Street this week.

Another volatile stretch sent the down to five-month lows before rebounding, while the Dow traveled more than 700 points over two days. And Wednesday's futures prices pointed to a 100-point gain at the open.

This is just the beginning as monetary policy conditions tighten the vise on this bull market, says Peter Boockvar, chief investment officer at Bleakley Advisory Group.

"My most important concern, and it's been for a while, has been the tightening of monetary policy, and now it's coming to a head," Boockvar said Tuesday on CNBC's "Futures Now."

The Federal Reserve has signaled a willingness to raise interest rates again in December, tapping the brakes on a U.S. economy juiced up by tax cuts and unemployment at 49-year lows. Aexpressed by the Jewish and Christian faiths.)

With regard to science, I think it is important to make a distinction between science as an ideal, and science as big business (or big government.) Beyond that, I think that the biggest issue with science is that it purports to be "value free", which has bled into the culture of the scientific community which assumes that it has no responsibility for the consequences of its research. I agree that science should be value free, but I also believe that science should be a regulated profession with a code of conduct that binds scientists to take moral responsibility for the consequences of their research.

Digging Your Own Well: Daoism as a Practical Philosophy

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About Me

Life is a strange journey sometimes. I was born


The last five weeks have been a blur. This is the longest I've gone without blogging, but I have to admit that I'm been insanely busy. There also hasn't been too much going on on the farm (due to lack of time, mostly), but we finally got caught up on some things the last few days. The good news is that I only have two more weeks until the class I'm teaching is finished--phew!

I was able to secure two bee packages from a local source this week. I've been looking forever, but didn't want to drive very far, and also wanted to wait until the weather was going to be warm. Hopefully they'll have enough time to build up their winter stores (I'll feed later in the summerbrain function, a task-based functional neuroimaging (fMRI) study with verbal fluency (VF) task showed CDs' activity intensity in right hemisphere (key homologous) regions to be positively correlated with disease duration^[@CR13]^; another study with a stress task consisting of Stroop color-word interference showed increased activity in the midcingulate cortex in CDs' which possibly indicates an association between stress and symptomatic disease^[@CR14]^; Another study showed increased sub-cortical activity (i.e. cingulate cortex, insula, amygdala, thalamus, hippocampus that correlate to trait anxiety and uncertainty intolerance) in CDs' while responding to an uncertainty condition^[@CR15]^. Moreover, a resting-state fMRI study in CDs' showed abnormal connectivity within the default mode network (DMN) network (i.e. anterior cingulate cortex, superior medial frontal gyrus, middle cingulate cortex), which is known to be involved in processes such as internal


suggests that brain white matter microstructural properties are significantly altered in CD patients. Our findings support the growing number of studies that have applied neuroimaging to examine the neural substrates impacted by the disease as well as its relationship to cognitive or affective processes^[@CR5]^ and disease duration^[@CR3],[@CR8],[@CR20]^.

FA, which quantifies the directionality of diffusion within a voxel between 0 (undirected, isotropic) and 1 (directed, anisotropic), is derived from the diffusion tensor and is the most commonly studied diffusion parameter of white matter microstructural properties related to the integrity of the fiber tract^[@CR21],[@CR22]^. Increased (or decreased) FA in white matter tracts involved in cognitive processes is related to improved (or declined) cognitive function^[@CR7],[@CR23]^, but the reduced FA in white matter tracts related to affective processes is related to increased severitycingulate and dorsolateral frontal regions^[@CR66]--[@CR69]^), is mainly related to sensorimotor^[@CR70],[@CR71]^ and also to executive function, working memory^[@CR72]^ and the levels of anxiety and depression^[@CR73]^. The FMi, a commissure pathway connecting the bilateral frontal regions^[@CR66]^, is associated with sensory and auditory processing^[@CR74]^ as well as emotional disorders^[@CR24]^. Moreover, the FMi and ATR can affect attention-control skills^[@CR67]^. Therefore, together with the functions of language and psychiatric symptoms mentioned above, CD duration may affect many neural functions.

Limitations {#Sec10}
-----------

This study was limited by a modest sample size. First, increasing the sample size would be particularly important to power the analyses for identification of neural correlates linked to behavioral performances in CD patients. Second, here we did not collect patients' information about previous medication use which may have lasting neural effects that could


IR-prepared FSPGR (Fast Spoiled Gradient Recalled Echo), MRI sequence with 156 axial slices was performed for each participant using the following parameters: TR = 8.132 ms; echo time (TE) = 3.18 ms, inversion time (TI) = 450 ms; field of view = 256 × 256 mm^2^; matrix size = 256 × 256; in-plane resolution =1 × 1mm^2^; slice thickness = 1.0 mm; excitation flip angle α = 12°.

Data preprocessing {#Sec19}
------------------

All diffusion data were processed using the "Pipeline for Analyzing braiN Diffusion images" (PANDA): a toolbox implemented in MATLAB

(<http://www.nitrc.org/projects/panda/>)^[@CR93]^. This software employs several neuroimaging processing modules including the FMRIB Software Library (FSL), the Pipeline System for Octave and Matlab (PSOM), the Diffusion Toolkit, the MRIcron to automatically perform a series of steps (i.e., skull removal, correction of eddy current distortion, build diffusion tensor models)^[@CR93]^.

Tract-Based Spatial Statistics (TBSS) were employed to evaluate voxel-based group differences for the values of fractionaland Japan

2x

We’re excited about these updates for many reasons. First: more people means more ideas. Since a lot of our content comes from Pinners saving their favorite ideas from around the web, an expanded audience means that additional content comes onto the platform.

This growth also means more opportunities for brands to reach their audience on Pinterest. As we continue to grow faster than ever, we’re adding new business programs too. Recent initiatives include bringing ads to new markets, launching Promoted App Pins and introducing Pinterest Propel, our new program for small businesses and agencies.

We truly appreciate all that you do to make Pinterest great for Pinners. Thanks for being here with us!

—Jon Kaplan, Head of Global Partnerships, currently saving ideas to For the Home


A gas turbine engine typically includes a compressor section, a combustor section, and a turbine section. Air entering the compressor section is compressed and delivered into the combustion section where it is mixed with fuel and ignited to generate a high-speed exhaust gas flow. The high-speed exhaust gas flow expands through the turbine section to drive the compressor section. In the case of a turboshaft engine, the engine drives an output shaft to create shaft power instead of thrust. The output shaft may be used to drive devices, such as a rotary wing aircraft, a generator, or a vehicle. There is an increasing desire to improve the power output and fuel efficiency of these engines to extend operating distances for rotary wing aircraft or vehicles and to reduceThe BlackBerry 9360 is the latest BlackBerry in the Curve series. While the Curve series is usually billed as a bare-bones device, this latest Curve actually comes with NFC. We’re bullish on NFC because it’s the missing piece of the mobile wallet puzzle that we’ve been waiting for. If you’re looking for a white 9360, it looks like Rogers will have it soon.


---
abstract: 'Due to the momentum transfer $r \equiv p - p''$ from the initial proton to the final, the “asymmetric” matrix element $\langle p'' | G \ldots G |p \rangle$ that appears in the pQCD description of hard diffractive electroproduction does not coincide with that defining the gluon distribution function $f_g(x)$. I outline a lowest-twist pQCD formalism based on the concept of double distribution $F_g(x,y)$, which specifies the fractions $xp$, $yr$, $(1-y)r$ of the (lightlike) initial momentum $p$ and the momentum transfer $r$, $resp.,$ carried by the gluons. I discuss one-loop evolution equation for the double distribution $F_g(x,y;\mu)$ and obtain the solution of this equation in a simplified situation when the quark-gluon mixing effects are ignored. For $r^2=0$, the momentum transfer $r$ is proportional to $p$: $r =\zeta p$, and it is convenient to parameterize the matrix element $\langle p-r | G \ldots G |p \rangle$ by an asymmetric distribution function ${\cal F}_{\zeta}^g (X)$ depending on the total fractions $X \equiv x+y \zeta$ and $X-\zeta = x- (1-y) \zeta$ of the initial proton momentum $p$ carried by the gluons. I formulate evolution equations for ${\cal F}_{\zeta}^g (X)$, study some of their general properties and discuss the relationship between ${\cal F}_{\zeta}^g (X)$, $F_g(x,y)$ and $f_g(x)$.'
---

100000

-48pt -0.5cm -0.5cm

CEBAF-TH-96-06\
Corrected

[**Asymmetric Gluon Distributions and Hard Diffractive Electroproduction**]{}

[A.V. RADYUSHKIN]{}\
[*Physics Department, Old Dominion University,*]{}\
[*Norfolk, VA 23529, USA*]{}\
[*and*]{}\
[*Thomas Jefferson National Accelerator Facility,*]{}\
[*Newport News,VA 23606, USA*]{}

[*1. Introduction.*]{} As shown in ref.[@bfgms], at high virtualities of the virtual photon $\gamma^*$, one can apply pQCD factorization to study the process of hard diffractive exclusive electroproduction of


vector mesons $\gamma^* + p \to V + p'$. In the approach of ref.[@bfgms], the non-perturbative information related to the proton is described by the matrix element of a two-gluon operator approximated by the gluon distribution function $f_{g}(x)$. However, as noted in ref.[@afs], due to the momentum transfer $r \equiv p - p'$ from the initial proton to the final, the two gluons carry, in fact, different fractions of the original proton momentum, $i.e.,$ the matrix element of the gluonic operator in this case does not coincide with that defining the gluon distribution function. As emphasized by X.Ji [@ji], one should deal in this case with a new type of functions (he calls them “off-forward parton distributions”) which differ from $f_{g}(x)$, even if $t \equiv r^2$ vanishes. Myof the asymmetric distribution function ${\cal F}_{\zeta}^g (X)$ and discuss the relationship between this function, the double gluon distribution $F_g(x,y)$ and the usual gluon distribution function $f_g(x)$.

[*2. Double distributions.*]{} The amplitude for the elastic electroproduction process $\gamma^* p \to p' V$ depends on the momentum $p$ of the initial proton, the momentum transfer $r=p-p'$ and the momentum $q$ of the produced vector meson. We will consider the limit in which one can neglect the squares of the meson $q^2 \equiv m_V^2$ and proton $p^2 \equiv m_p^2$ masses compared to the virtuality $-Q^2 \equiv (q-r)^2$ of the initial photon and the energy invariant $p \cdot q$. Thus, we set $p^2=0$ and $q^2 = 0$, and use $q$ and $p$ as the basic Sudakov light-cone 4-vectors. In the diffractive region,


( $X \geq Z$ in the second one). However, if the initial fraction $Z$ is less than $\zeta$, the evolved fraction $X$ cannot be larger than $\zeta$ or, what is the same, the parameter $Y \equiv X/\zeta$ specifying the fraction $Yr$ of the momentum transfer $r$ carried by this gluon cannot exceed $1$. This property is a characteristic feature of the evolution of distribution amplitudes.

Qualitatively, the evolution of the asymmetric distribution functions proceeds in the following way. Due to the GLAP-type evolution, the momenta of the partons decrease, and distributions become peaked in the regions of smaller and smaller $X$. However, when the parton momentum degrades to values smaller than the momentum transfer $r = \zeta p$, the further evolution is like that for a distribution amplitude: ittends to make the distribution symmetric with respect to the central point $X= \zeta/2$ of the $(0, \zeta)$ segment. In two extreme cases, when $\zeta =0$ or $\zeta =1$, the evolution is more trivial. For $\zeta =0$, ${\cal F}_{\zeta}(X)$ reduces to a usual distribution function governed by the GLAP evolution equation, while for $\zeta =1$ we always have $Z \leq \zeta$ for the initial fraction and the function ${\cal F}_{\zeta}(X)$ experiences a purely Brodsky-Lepage evolution. In other words, $W_{\zeta =0}^{ab}(X,Z;g) = P_{ab}(X/Z,g)/Z$ and $W_{\zeta =1}^{ab}(X,Z;g) =V_{ab}(X,Z;g)$ [^4].

[*7. Conclusions.*]{} In this letter, I demonstrated that one can describe the asymmetric matrix element $\langle  \bar \zeta p | G \ldots G |p \rangle$ either by the universal double distribution $F_g(x,y)$ or by the asymmetric distribution function ${\cal F}_{\zeta}(X)$ which


the data excluding these six teams:

The pattern here is pretty stark. Simply by excluding four periods where an individual club was a basket case for a long time, as well as the special cases of GWS and Gold Coast, we can see that over half (57%, 25 of 44) of cellar-dwelling teams make the top 4 at some point in the following four years. Looking at finals entries, 95% of teams – virtually all of them who don’t stay in the bottom 4 for a long time – make finals in the following four seasons, with 64% sitting in finals three years down the track from their bottom 4 finish.

The implications of this are pretty seemingly pretty simple. As long as a team doesn’t fall into a rebuildingappeals.

       * Pursuant to 5TH CIR. R. 47.5, the court has determined that this opinion should not
be published and is not precedent except under the limited circumstances set forth in 5TH
CIR. R. 47.5.4.
    Case: 16-51446    Document: 00514511975     Page: 2   Date Filed: 06/13/2018

                                 No. 16-51446
      The Supreme Court has held that, for removal under § 1443(1) to be
appropriate, “it must appear that the right allegedly denied the removal
petitioner arises under a federal law ‘providing


as root (mysql -u root -p) and enter each of the following lines:

You may want to fine-tune your database settings further than this, but this is a good start.

Make it web-accessible

We now have PHP and MySQL running on the box, but cannot access it through a browser. We need to configure the web server and set up an Elastic IP.

Web Server

First, let’s create a test PHP file that will be accessed by the browser. Create directories so that you can put your file in /opt/app/current1. Make an index.php file that contains whatever you want.

If you want to FTP transfer files to your server, you’ll want to give the ec2-user permissions to modify files in your web directory:

sudo chown ec2-user /opt/app/current

To set up the web server, httpd, we needto new mysqli() had to be removed since it expected a long, and I had to add
$row = mysqli_fetch_row($result)
echo $row[0];
to get the desired output, as $result would not convert to string. Perhaps I installed PHP different from the above, or did something strange in putting the string in the test database.

Thanks – was great help. The only thing that i tripped up on was that i can only FTP files to the /home/ec2-user folder, and then sudo mv them to where I want them. I was trying to put them directly where i needed them in FileZilla. Not a problem when i know to do it

It might be worth noting after your instructions to “Make an index.php file that contains whatever you want.” that the ownership of index.php


/*
 * Licensed to the Apache Software Foundation (ASF) under one
 * or more contributor license agreements.  See the NOTICE file
 * distributed with this work for additional information
 * regarding copyright ownership.  The ASF licenses this file
 * to you under the Apache License, Version 2.0 (the
 * "License"); you may not use this file except in compliance
 * with the License.  You may obtain a copy of the License at
 *
 *     http://www.apache.org/licenses/LICENSE-2.0
 *
 * Unless required by applicable law or agreed to in writing, software
 * distributed under the License is distributed on an "AS IS" BASIS,
 * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 * See the License for the specific language governing);
        }

    public void testSubclassClosureC()
        {
        Model m = model( "A rdfs:subClassOf B; B rdfs:subClassOf C; X rdfs:subClassOf C; Y rdfs:subClassOf X" );
        subClassClosure( m );
        assertIsoModels( model( "A rdfs:subClassOf B; B rdfs:subClassOf C; A rdfs:subClassOf C; X rdfs:subClassOf C; Y rdfs:subClassOf X; Y rdfs:subClassOf C" ), m );
        }

    public void testSubclassClosureD()
        {
        Model m = model(


       assertIsoModels( model( "A rdfs:subClassOf B; B rdfs:subClassOf C; A rdfs:subClassOf C" ), m );
        }

    protected void subClassClosure( Model m )
        { ModelExpansion.addSubClassClosure( m ); }
    }
for conventional BCH code and the RS code, has excellent error correction performance with hard decision information, and the BC-BCH code decoder is less complex and more easily implemented than conventional BCH code decoders. However, soft decision information is indispensable for improving the decoding performance of BC-BCH code. To this end, information similar to soft decision information needs to be generated by raising the quantization level of the hard decision information. One option is to re-read the pages where errors occur by changing the threshold voltage of the page. However, it is not efficient to re-read pages by changing the threshold voltage because it is complex and the decoding is delayed.
Therefore, when threshold voltage is read limitedly, an optimal reference voltage for minimizing the error rate of the


after the exercises.

### 3.2.1. Wearable Device(s) {#sec3dot2dot1-sensors-20-02713}

Most of the wearable devices are developed based on inertial sensors that are comprised of an accelerometer and gyroscope. Accelerometers are used to measure accelerations but are unable to measure the rotations or angles. Therefore, these can not help with detecting the turns during walking activities. On the other side, gyroscopes serve in detection of angular velocity of body and also there are less chances of mechanical noise than in an accelerometer's case, hence turning is better assessed during motion. Being critical with gyroscopes, it can be mentioned that their drawback relates to the high power consumption during long-term recording. Battery life, type, and number of inertial sensors, sampling rate, recording and processing time, and, most importantly, the learning algorithm is themotor activities.

### 3.2.3. Algorithms for Analysis of Gait Pattern {#sec3dot2dot3-sensors-20-02713}

However, besides the acquisition of a robust data set from wearable insoles, another noteworthy aspect regards the algorithms that accurately learn from the data and also accurately predict \[[@B41-sensors-20-02713]\]. Machine learning algorithms are currently considered as the pervasive part of the smart environment, but PD data are different in a more sophisticated way from the traditional clinical data as it is comprised of high-frequency continuous digital sensors readings of around tens of thousands per second.

ML algorithms such as random forest (RF), decision trees (DTs), logistic regression (LR), support vector machine (SVM), hidden Markov models (HMMs), naive Bayes, clustering algorithms, and neural networks (NNs) have been implemented successfully in medicine \[[@B32-sensors-20-02713]\] and recently expanded to use them for sensor based


the Ambulosono wearable works with an iOS GaitReminder App that produces auditory instructions while continuously recording step sizes via iOS gyro and accelerometers (after correcting the limb length, angular excursion, signal filtering, and drift). During the tests, the patients uniformly received a set of standardized auditory instructions, tailored by clinical guidelines, through wireless headphones, which contain verbal encouragement, specification of walking speed (e.g., comfortable or fast), and reminders of completed walking time. Step features collected via GaitReminder App show an average of \<10% difference when it was tested against direct video measurements, and an analogous error rate was conjointly found once the App was used for treadmill walking or over-ground walking activities. A new generation of the Ambulosono sensor was designed, and it demonstrated a \<5% error ratethe optimal location, amount of training under supervision, mode of delivery, intensity of exercise, and the type of training required to get the benefits.

With respect to rehabilitation evaluation, the TUG, 6MWKT, and 10MWKT tests are traditional gold standard examination tests for monitoring gait deflation, providing treatment analysis such as of physical therapy and various exercises. However, these tests are time consuming and task performance related, and the results are affected by many multiple variables like walking area, task complexity assigned to patient, physical exertion by participant, and incapability to finish the task as a result of fatigue. Among these, the TUG test has been used for decades, but currently new methods are being introduced from which the automatic assessment system brings remarkable results. These wearable devices help not


0.001). ML postural sway SD was not much different between the smooth and textured insoles (Fisher's LSD: *p* = 0.127)
  Mustufa, Ys Ashad \[[@B39-sensors-20-02713]\] 2015   Multi-layered rugged, low cost, scalable and durable packaged insoles. Developed with Piezoelectric, temperature, accelerometer and force sensors                                             Timed up and go test (TUG)                                 micrograms per liter (ig/l) as a monthly average."
Generally, to meet water quality standards a polluter must comply with effluent limitations. The CWA defines an effluent limitation as "any restriction established by a State or the [EPA] Administrator on quantities, rates, and concentrations of chemical, physical, biological, and other constituents which are discharged from point sources into navigable waters, the waters of the contiguous zone, or the ocean, including schedules of compliance." (33 U.S.C. § 1362(11).)[1] "Effluent limitations *79 are a means of achieving water quality standards." (Trustees For Alaska v. E.P.A. (9th Cir.1984) 749 F.2d 549, 557, italics in original.)
NPDES permits establish effluent limitations for the polluter. (33 U.S.C. §§ 1311, 1312, 1342(a)(1); EPA v. State Water Resources Control Board (1976) 426 U.S. 200, 205, 96 S.Ct. 2022,


WQBELs whenever the permitting agency determines that pollutants "are or may be discharged at a level which will cause, or have the reasonable potential to cause, or contribute to an excursion above any State water quality standard, [including narrative criteria for water quality]." (Italics added.) According to the State Board's decision, "The analysis to determine what pollutants must have [WQBELs] is commonly called the `reasonable potential analysis.' "
Section 122.44(d)(1)(iii) provides that "When the permitting authority determines . . . that a discharge causes, has the reasonable potential to cause, or contributes to an in-stream excursion above the allowable ambient concentration of a State numeric criteria within a State water quality standard for an individual pollutant, the permit must contain effluent limits for that pollutant."
Section 122.44(d)(1)(vi) provides that "Wherethrough which storm water from several other industrial facilities drains into the Bay. Thus, only a portion of the Bay discharge from Waste 001 comes from the Refineryalthough that fact was not known at the outset, but only emerged over time.
Five of the 17 dioxins discussed above are consistently found in the Refinery's wastewater. The five do not include 2,3,7,8-TCDD.
The Refinery's discharges are governed by NPDES Permit No. CA0004961, first *82 issued by the Regional Board in 1988. In 1993, the Regional Board reissued the permit, and imposedapparently for the first timea numeric WQBEL for dioxins. The 1993 permit included a WQBEL of 0.14 picograms per liter (pg/L) of "TCDD equivalents."[7] The phrase "TCDD equivalents" refers to the 17 toxic dioxins discussed above. The WQBEL of 0.14 pg/L


613, 52 Cal.Rptr.2d 846.) The factors governing the degree of judicial deference to agency interpretations are set forth in Yamaha Corp. of America v. State Bd. of Equalization (1998) 19 Cal.4th 1, 78 Cal. Rptr.2d 1, 960 P.2d 1031 (Yamaha). These factors include the court's assumption that the agency has the technical knowledge and expertise to interpret complex regulations in a technical or complex scheme. They also include the likelihood that agency officials have reached the interpretation after careful and studied review and input from the public. (See Yamaha, supra, at pp. 12-13, 78 Cal. Rptr.2d 1, 960 P.2d 1031.) Those factors are present in this case.
In light of the supporting record, and our reading of the applicable statutes and regulations, we agree with the agencies' determinations.[12] Respondents'[the 1995 permit] to ensure that the waterbody will not be further degraded. In addition to interim concentration limits, interim performance-based mass limits are required to limit the discharge of [EPA-identified] pollutants to their current levels. These interim mass limits are based on recent discharge data.... Where pollutants have existing high detection limits [such as dioxins], interim mass limits are not required because meaningful performance-based limits cannot be calculated for those pollutants with non-detectable concentrations. However, [the Refinery is] required to investigate alternative analytical procedures that result in lower detection limits.... [The Refinery] will also be required to conduct a study to investigate the feasibilit
y and reliability of increasing sample size to reduce the detection limits for [dioxins]."
[9]  The regulation provides that so-called "best management practices" may


and possibly not propagating down into the files. The required permissions are determined by the user identity of the Application Pool. By default and best practice is to run it as the 'app pool identity' so it's basically it's own user. If you are just looking for a dev setup you should get into the app pool settings and have it run as 'System' (very insecure) but that could get it working in one step.
The proper way to do it is to run the permissions batch script for umbraco. Unfortunately their site seems to be undergoing a restructuring and the page is down, but I found a google cache version: http://bit.ly/1GvPl6n
I'd recommend the powershell script and running powershell as administrator. I had to copy-paste an editedshe toured with throughout the summer.

She told the newspaper that while she knows the cancer is untreatable, it is also possible for some people to live for more than a decade on medication, and she has high hopes for what medical discoveries can be made in the coming years.

Bernie was first diagnosed with breast cancer in 2010 and although her chemotherapy left her bald, she continued her TV work.

She has seen been a supporter of breast cancer charities and earlier this month took part in public appearances to raise awareness of the disease.


benefit of the doubt. But the more I listened the more he sounded to me like any modern conservative, just slowed down and with a bit more cheer. He solidified my opinion of conservatism as a movement in retreat, mowed down by its own rage like a soldier on the beach in Saving Private Ryan, trying to stuff its entrails back into its torso for one more run at the enemy. All that’s left for “happy warriors” like Steyn to do now is cash in on a few more book sales and lectures. The summit of their mission will never be reached, and I think Steyn’s breed understands this.

What Steyn has done is let the cat out of the bag about what is happening within conservative thought; thetarget. But how has the Hyperpower come to this?

Conservatism can’t help owning its share of the blame; their ideas simply did not work when they were given their best chance to succeed. In conservative hands, America’s economy became the plaything of the free market and would now resemble Somalia’s if not for overwhelming government interference, the thing conservatives were pledged to prevent. And the economy still has not righted itself despite as much genuflecting to Wall Street as any president has ever done. Meanwhile, our bicep-flexing wars against Islam, the longest wars in American history, have left the entire nation in a tepid mood. Finally, no one believes anymore that Republicans didn’t inflate the debt as much as Democrats. So we must ask: what is left in the


for the Secretary General explained(8):

“Spokesperson: Well, the Mission has sent its observations on the al-Houla killings to the Secretary-General for his consideration. The Secretary-General is in turn sending these observations to the relevant UN bodies monitoring human rights in Syria. And once these bodies complete their work, the findings on what I think everybody agrees was a terrible incident will be presented by the Secretary General to the Security Council,”

This statement raises the question of why the findings of UNSMIS were to be diverted to what he referred to as “UN bodies monitoring human rights” rather than presented directly to the Security Council as the Security Council had requested in their May 27 press statement.

The Spokesperson’s statement, however, acknowledges the UNSMIS Report on Houla was received by theSuch a statement is contradicted in its own August Report, which does include references to information from UNSMIS, just not with regard to the Houla massacre.

In his June 15 press briefing, General Mood said the UNSMIS Report on Houla included statements and interviews with locals with one story and statements and interviews with locals with another story. The August Report of the CoI tells only one story and claims that they either do not have other information or that any other information they know of is inconsistent, so that they have accepted that there is only one story. The Reports that the CoI produced had no on-site interviews or statements, but only telephone or Skype interviews with insurgents or those supporting the account of Houla presented by the


the Security Council requested the Secretary-General, with the involvement of UNSMIS [United Nations Supervision Mission in Syria], to continue to investigate these attacks and report the findings to the Security Council.” The url is:

http://www.un.org/News/Press/docs/2012/sc10658.doc.htm

5) Stephanie Nebehay ,“Most Houla victims killed in summary executions: UN”, Tuesday, May 29, 2012.

http://www.reuters.com/article/2012/05/29/us-syria-un-idUSBRE84S10020120529

6) Press Conference with Major General Robert Mood in Damascus, June 15, 2012, Video Part 2. The section where General Mood describes

the Report on Houla starts at min: 3:10 to 4:17 . The url is:

7) Describing the investigation by UNSMIS into the Houla massacre and the report UNSMIS submitted to UN headquarters, General Mood tells

journalists, as transcribed from the video:

“The statement we issued after el Houla is still valid. Which means we have been there with an investigating team. We haveMarinella Corregia worries the HR commissioner talks only to its sources: the opposition.”

http://www.rt.com/news/houla-massacre-un-syria-635/

Thursday, May 31 2012, “UN report on Houla massacre? But they only talk to Syrian opposition – by phone, “Uprooted Palestinians”.

http://uprootedpalestinians.blogspot.com/2012/05/river-to-sea-uprooted-palestinian-views.html

15) General Mood Meets the Press, Damascus, July 5, 2012.

See for example from min. 17:25-19:00 General Mood describes how UNSMIS has established an impartial system with “exactly the mechanism that addresses both sides in the same way”.

16) I have had two experiences when I asked either present or former UN officials connected for the UNSMIS Report.. In both cases I was referred to the CoI Reports with no indication about what happened to the UNSMIS Report on Houla.

17) See for example: Marinella Correggia, “THE RECENT REPORT ON SYRIA BY THE “INDEPENDENT INTERNATIONAL COMMISSION OF INQUIRY” (CoI)

mandated


is to offer shares to senior management: for the United States, the average annual dilution of shares for chief executive and senior management pay was 2.5 percent. If dilution is good enough for bosses’ bonuses, it should be good enough for workers’ pay packets. This is class politics.

And let’s be clear about who those shareholders are. Despite mythology, they aren’t pension funds. Industry analyst Mercer’s survey shows that just 7 percent of UK pension funds by value are held in UK shares, with funds preferring to hold either equities from overseas, or UK government debt — now accounting for 50 percent of UK pension fund holdings. And after decades of neoliberalism, individual share ownership has collapsed, from 54 percent in 1964 to just 12 percent today.

What’s more, 54a bitumen-polymer composition that contains between 1 and 20% by weight of an atactic ethylene-propylene copolymer, with a molecular mass whose weight is between 10 000 and 40 000.
This copolymer, obtained by extraction using pentane, as a sub-product of the manufacture of isotactic polypropylene polymers, is amorphous.
During their research work in this field, the applicants established that, surprisingly so, it is possible to incorporate into bitumens the polyolefins that until now were considered as non incorporable in bitumens.


what they have done to all of us.”

Fox News isn't the only entity owned by Murdoch that de Blasio has gone after this year. The mayor said in May that The New York Post is "divisive" and that he wouldn't "shed a tear if that newspaper is no longer here.”

Fox News, which was once again the most-watched cable news network in July, is known for its supportive coverage of Trump, with hosts such as Sean Hannity consistently defending the president. Hannity has also echoed Trump's charge that much of the media is "fake news."

Fox Business Network host Stuart Varney addressed De Blasio's comments on Wednesday.

“When Chick-fil-A opened its first restaurant in New York City, the Mayor Bill De Blasio called for a boycott," Varney said. "Chick-fil-A defends traditionalTrp77 and Phe117 in the Pk-FKBD were considerably important for catalysis as underlined by significant reduction of PPIase activity upon mutations at these residues. Further, inhibition activity of Pk-FKBP35 towards calcineurin phosphatase activity revealed that the presence of FKBD is essential for the inhibitory property, while TPRD may be important for efficient binding to calcineurin. We then discussed possible roles of FKBP35 in Plasmodium cells and proposed mechanisms by which the immunosuppressive drug, FK506, interacts with the protein.


when the C++ standard library
 *  implementation does not support * locales.
 */
template<>
inline std::basic_string<wchar_t> default_true_name<wchar_t>()
{ return L"true"; }
#  endif
#endif

/**
 * \brief Returns a string containing the default name for the indeterminate
 * value of a tribool with the given character type T.
 *
 * This routine is used by the input and output streaming operators
 * for tribool when there is no locale support or the stream's locale
 * does not contain the indeterminate_name facet.
 */
template<typename T> std::basic_string<T> get_default_indeterminate_name();

/// Returns the character string "indeterminate".
template<>
inline std::basic_string<char> get_default_indeterminate_name<char>()
{ return "indeterminate"; }

#if !defined(BOOST_NO_CWCHAR)
/// Returns the wide character string L"indeterminate".
template<>
inline std::basic_string<wchar_t> get_default_indeterminate_name<wchar_t>()
{ return L"indeterminate"; }
#endif

// http://www.cantrip.org/locale.html

#ifndef BOOST_NO_STD_LOCALE
/**
 * \brief A locale facet specifying the name of the indeterminate
 * value of a tribool.
 *
 * The facet is used to75 F.3d 290 (7th Cir.1996) (summary judgment appropriate where, despite an expert's opinion to the contrary, the undisputed facts would not allow a reasonable jury to infer proximate cause).

16
The Harmons also allege OKI negligently maintained the Rider.  They point out that OKI serviced the forklift monthly from November 1988 to December 1990 but not during the 6 months before the accident.  The Harmons contend summary judgment was inappropriate against OKI because:  (1) OKI's motion failed to contain a statement of undisputed facts as required by local rules;  and (2) Judge Hamilton improperly struck Winsor's statement that the Rider had been used for 338 hours without being serviced and that service should be performed every 100 hours.

17
The lack of proximate cause is even more glaring


things, a statement of undisputed material facts, and it's true that OKI didn't include one.  However, the rule is designed to let the court and the opposing party know what legal and factual issues are on the table.  Neither the court nor the Harmons could have been confused.  OKI's brief was only 3-pages long, and the few assertions of fact in it were found in a 3-page affidavit and a 14-page excerpt from a deposition.  There was certainly no prejudice from this technical failure.

19
AFFIRMED.

Quite simply because he could not be sure that the Chelsea player had in fact intended to insult Mr Ferdinand.

For a start, the lip readers said they could not be clear about a couple of words in the exchange which, depending on which way you look at it, could have indicated whether or not Mr Terry was trying to insult Mr Ferdinand.

Secondly, nobody other than Mr Terry gave any evidence about what was actually said on the pitch. Mr Ferdinand said he did not know what Mr Terry had said until later. Nobody else on the pitch heard it - or if they did, they did not offer any evidence to that effect.

Thirdly, the judge said he accepted evidence that Mr Terry had learnt to live with the


formation \[[@ppat.1006240.ref023]--[@ppat.1006240.ref025]\]. A previous study reported that inhibition of Ars-induced SG formation in JEV-infected cells was due to sequestration of the SG protein Caprin 1 by the viral capsid protein \[[@ppat.1006240.ref024]\]. In the present study, co-localization of WNV capsid with Caprin1 was not observed. In addition, other types of cellular stressors, such as dithiothreitol (DTT) or heat shock, were shown to induce SGs with similar efficiency in mock- and WNV-infected cells indicating that flavivirus-mediated resistance to SG induction is specific for Ars treatment and not due to virus-mediated disabling of SG assembly. Infection of cells with WNV induced the production of detectable ROS and the levels increased with time after infection. However, rapid upregulation of antioxidant pathway gene products mediated by the transcription factors ATF4 and Nrf2 alsowith Ars for 30 min starting at 28 hpi or with BSO before and after infection as described above and then with Ars for 30 min at 28 hpi. As expected due to the increased ROS production induced by Ars, more than 90% of the Ars-treated, mock-infected cells were SG-positive but only about 5% of the WNV-infected cells were SG-positive ([Fig 8A and 8B](#ppat.1006240.g008){ref-type="fig"}). The percent of SG-positive, WNV-infected cells increased from 19.5% after BSO treatment alone to 41.5% after combined treatment with BSO and Ars. These results indicate that continued GSH synthesis is an important component in determining the amplitude of the virus-induced antioxidant response.

To determine whether the BSO-induced SGs are canonical, cells were incubated with cycloheximide (CHX) for 5 min and then fixed and processed for


ER that contained high concentrations of viral replication complexes. In both uninfected ([S3 Fig](#ppat.1006240.s003){ref-type="supplementary-material"}) and mock-infected A549 cells and C57BL/6 MEFs, the mitochondria were partially tubular/tubular and the morphology did not change after WNV infection except in regions with high concentrations of viral replication complexes where they were partially fragmented ([Fig 10A](#ppat.1006240.g010){ref-type="fig"}).

![WNV infection induces changes in mitochondrial morphology.\
(A) BHK cells, C57BL/6 MEFs and A549 cells were mock-infected or infected with WNV (MOI of 3). At 24 h after infection, cells were incubated with RMT for 30 min. Cells were then washed with 1 X PBS, fixed, permeabilized and processed for IFA. Areas in the white boxes were enlarged. Circular, tubular and fragmented mitochondria are indicated. (B) BHK cells were mock-infected or infected with WNV (MOI of 3) andcells by Western blotting. It was previously suggested that levels of phosphorylated eIF2α below the limits of detection by Western blotting could facilitate ATF4 translation in DENV-infected cells \[[@ppat.1006240.ref034]\]. ATF4 activates the expression of Gadd34, a subunit of protein phosphatase 1 (PP1) which dephosphorylates eIF2α and thus, ATF4 negatively feeds back on eIF2α phosphorylation. In the present study, ATF4 upregulation was not observed after WNV infection of MEFs expressing a mutant eIF2α that cannot be phosphorylated or of PERK-/- MEFs indicating that ATF4 upregulation depends on PERK-mediated eIF2α phosphorylation in WNV-infected cells. Although the level of eIF2α phosphorylation induced by WNV-infection is sufficient to activate ATF4 translation, it is not sufficient to induce SG formation. PERK is typically activated by ER stress and the unfolded protein response \[[@ppat.1006240.ref075]\].


of a recent study observed some elongation of tubular mitochondria after infection of Huh7 cells with DENV or ZIKV but not with WNV and equated this with increased mitochondrial fusion \[[@ppat.1006240.ref077]\]. The absence of an increase in mitochondrial fission was attributed to inhibition of Drp1 phosphorylation mediated by the viral protein NS4B and to decreased levels of CDK1, one of the kinases that phosphorylates Drp-1 \[[@ppat.1006240.ref046]\]. In the present study, we also observed no increase in p-Drp1 levels in either WNV-infected cells or in Ars-treated, SG-negative, WNV-infected cells. In contrast, HCV and HBV infections promote mitochondrial fission by inducing the expression and phosphorylation of Drp-1 followed by its translocation from the cytosol to the mitochondria \[[@ppat.1006240.ref078], [@ppat.1006240.ref079]\]. One study proposed that DENV infections but not JEV infections enhanceCells were infected at a MOI of 0.1 and media incubated on the infected cells from 48 to 72 hpi was harvested, clarified, aliquoted and stored at -80°C. ZIKV infectivity was assessed by plaque assay on Vero cells using a protocol similar to that for WNV plaque assays on BHK cells. The titer of the stock virus pool was 5X10^6^ PFU/ml.

Chemicals {#sec016}
---------

Sodium arsenite (Ars), dithiothreitol (DTT) and N-Acetylcysteine (NAC) and puromycin were obtained from Sigma-Aldrich and buthionine sulphoximine (BSO) and cyclyheximide were was obtained from Santa Cruz Biotechnology.

Fluorescence microscopy, image processing and quantification {#sec017}
------------------------------------------------------------

BHK cells grown to 50 to 70% confluency on 15-mm diameter glass coverslips in a 24-well plate were infected with WNV at the MOI indicated in Results. For immunofluorescence assays (IFA), cells were fixed with


4% paraformaldehyde in phosphate buffered saline (PBS) for 10 min at room temperature and then permeabilized by incubation with ice-cold 0.1% triton X-100 in phosphate buffered saline (PBS) for 10 min. Coverslips were washed with PBS, blocked for 1 h with 5% horse serum (Invitrogen) in PBS and then incubated with primary antibody diluted in blocking buffer overnight at 4°C. After washing three times with PBS, the cells were incubated with appropriate AlexaFluor secondary antibodies (Invitrogen) (1:400) in blocking buffer. Cell nuclei were stained with Hoechst 33342 dye (Molecular Probes). The coverslips were washed with PBS and mounted on glass slides with Prolong Gold Antifade reagent (Invitrogen). Images were acquired with a 63X oil immersion objective on an LSM 700 laser confocal microscope (Zeiss, Germany) using LSM 5(Cell Signaling Technology), rabbit P-Nrf2 (Abcam), mouse anti-puromycin (Millipore), rabbit p-eIF2α (Cell Signaling), goat anti-TIAR (Santa Cruz Biotechnology), mouse anti-PABP (Thermo Fisher Scientific), rabbit anti-USP10 (Cell Signaling Technology), rabbit anti-G3BP1 (Proteintech), and rabbit anti-Caprin1 (Proteintech) diluted 1:400 in blocking buffer. AlexaFluor donkey anti-mouse or AlexaFluor donkey anti-rabbit or AlexaFluor donkey anti-goat secondary antibodies (Invitrogen) diluted 1:400 in blocking buffer was used.

For live cell imaging, mock-infected or WNV-infected (MOI 5) BHK cells grown to 70% confluency in chamber slides were incubated for 30 min at 37°C with one or more of the staining solutions listed below. CellROX Green reagent (Molecular Probes) was added to the media at a final concentration of 5 μM to detect oxidative stress. ThiolTracker Violet (Molecular Probes) was used at a final concentration 20 μM


grading system usually applied in China, which classifies silicosis as stage 0 (suspected cases), I, II or III. If a worker has silicosis of stage I or above, he will be defined as having definite silicosis. In an inter-reader comparison study between the Chinese and Internatinoal Labor Organisation (ILO) classification system (revised ED 1980), a good agreement of 89.3% was found between the Chinese stage I and ILO profusion category 1/1 \[[@b15-ijerph-08-02923]\].

The onset of silicosis was defined in this study as the date of the radiograph leading for the first time to classification as stage I or higher. For workers without silicosis, the end of the follow-up-period was defined as the date of the last X-ray examination.

2.3. Occupational Exposure Assessment
-------------------------------------

More than 100,000 historical industrial hygiene data dating backstarting date of follow-up). Highest exposure ever was defined as the highest annual average concentration ever experienced during the working lifetime. Since the main purpose of this analysis is the quantification of absolute risk of silicosis at low exposure levels rather than the identification of possible threshold values of silica dust exposures, no thresholds were assessed in this study \[[@b18-ijerph-08-02923]\]. Calculation of time-dependent person-years was performed with the help of Wood's algorithm \[[@b19-ijerph-08-02923]\]. The effect estimates were calculated by PROC GENMOD (SAS 9.2) \[[@b20-ijerph-08-02923]\].

In the second step, the expected long-term risk of silicosis was quantified for a selected target population based on the estimated exposure-response relationships \[[@b21-ijerph-08-02923]\].

In this analysis, the German population was chosen as the target population. The silicosis risk was quantified based on a typical exposure


for calculation of the incidence rate of silicosis and the exposure-response relationship as shown in [Figure 2](#f2-ijerph-08-02923){ref-type="fig"}.

[Figure 2a](#f2-ijerph-08-02923){ref-type="fig"} shows a dynamic change in silicosis incidence among workers exposed to dust over their whole working lives between the ages of 20 years and 65 years. Where workers begin employment aged 20 years, virtually no risk of silicosis is expected during the first 10 years of their working lives. Thereafter, the risk of silicosis increases rapidly, peaking around 35 years after the onset of exposure. After this point, the incidence decreases. This figure expresses the estimated exposure-response relationship between respirable crystalline silica dust exposure and silicosis over time.

The estimated exposure-response relationship between respirable crystalline silica dust exposure and silicosis was also presented by the cumulative risk estimator as shown inuncertainties (unknown external dust exposure, employment before 1950 or below the age of 15 years) were excluded from the data analysis. The conversion factors between total dust and respirable dust exposures were compared by the use of different measurement strategies. The content of crystalline silica in the dust was also quantified by comparison between different laboratories. Our analysis demonstrates that comparable crystalline silica content in the dust was found in different laboratories in the USA and Germany. However, conversion factors estimated with use of the German measurement strategy were about twice as high as those estimated with use of the US measurement strategy. In this analysis, conversion factors between total dust and respirable dust exposures were quantified on the basis of the German measurement strategy.

To quantify the stability


long-term risk of silica related health issues \[[@b6-ijerph-08-02923],[@b7-ijerph-08-02923]\]. In this analysis, we quantify the long-term risk of silicosis based on a cohort of Chinese pottery workers.

The long-term risk estimates developed in this study describe the probability of contracting silicosis due to a long-term exposure to respirable crystalline silica dust under special exposure levels or patterns. These risk estimates are accumulated over the whole working life. We applied the NIOSH approach \[[@b22-ijerph-08-02923]\], ignoring certain recommended refinements \[[@b23-ijerph-08-02923]\].

Previous estimations of the long-term risk of silicosis were based mainly on the assumption of a monotonic exposure-response relationship between cumulative crystalline silica dust exposure and the incidence or prevalence of silicosis. One important limitation of this assumption is that, time (especially latency) was not considered in the analysis. For a given cumulativeprot = funcprot();
    funcprot(0);
    execstr(strcat(removed + "=COMPAT_BLOCK; "));
    funcprot(prot);

    resumedBlocks = removed';

    // Put all resumed symbols into the parent scope
    //    Take care: resume() will also return to the parent scope
    execstr("[" + strcat([resumedLibs resumedBlocks], ", ") + "] = resume(" + strcat([resumedLibs resumedBlocks], ", ") + ");");
endfunction


of the commercial network deployment and the LTE standard technology evolution, currently base stations using different releases and terminals using different protocol releases widely exist in the market. Considering the difference in functions of the different protocol releases, the functions of devices based on different protocol releases will be quite different (even if the devices are based on the same protocol release, functions supported by different base stations and terminals may still have a big difference considering the manufacturing cost, the target market and other factors), and the maximum capability reached by the terminal under a certain base station depends on the intersection of capability of the terminal and the capability of the base station. For example, a base station based on technology of the 3GPP R11 release,(!$mysqli)
die("Can't connect to MySQL: ".mysqli_connect_error());

$stmt = $mysqli->prepare("SELECT cards.CARD_TYPE, display.PICTURE_ID
FROM cards
INNER JOIN display ON cards.DISPLAY_ID = display.DISPLAY_ID
WHERE display.DISPLAY_ID=? AND cards.CARD_TYPE =?" );

$displayid=11;
$cardtype='Mythic';

$stmt->bind_param("si", $displayid, $cardtype);
$stmt->execute();
$stmt->bind_result($image);
$stmt->fetch();
//header("Content-Type: image/jpeg");
echo $image;
?>

Warning: mysqli_stmt::bind_result(): : Number of bind variables doesn't match number of fields in prepared statement in

fix: Make sure to only return blob data in your queries if you are reading pictures from the database. (Delete cards.CARD_TYPE from SELECT statement.)

A:

Try these two fixes:

Get rid of: if (!$mysqli->query($stmt)) { printf("Errormessage: %s\n", $mysqli->error); }
You execute the query when you call execute()
You need to bind 2 parameters, and you pass two but only list one type.  Change the bind_param call to:
$stmt->bind_param("si", $cardtype, $displayid); // s for string, i for int

EDIT: Try changing the code to this:
$stmt = $mysqli->prepare("SELECT cards.CARD_TYPE, display.PICTURE_ID
FROM cards


Q:

Import data from mongodb

When I import data from mongodb using jupyter, during the import process, my memory is 35% but my cpu is between 100% to 135%. It takes such a long time to import data. But I am not sure where is the bottleneck in this case. My code is below
So according to the other users in SO, this is already indexed. What else can I do to speed up the process of importing data into my pc ?
{
    "_id" : ObjectId("5ad0ade0bef1fc2fba99489d"),
    "property_a" : 0.0,
    "property_b" : 0.0,
    "property_c" : 0.0,
    "property_d" : 0.0,
    "property_e" : 0.0,
.....

}

The code I use to import the data is as follows, andArablu, East Azerbaijan

Arablu (, also Romanized as ‘Arablū) is a village in Aliabad Rural District, in the Central District of Hashtrud County, East Azerbaijan Province, Iran. At the 2006 census, its population was 39, in 7 families.

References

Category:Towns and villages in Hashtrud County


Sun) to receive radiation. Typically, the electrical contact layer on the front side of the cell is formed in a grid-like pattern, which includes a plurality of metallic fingers that are manufactured to be as small as possible so as to limit blockage of light prior to the light reaching the absorber region. The electrical contact layer on the back side of the solar cell generally covers the entire back side of the solar cell.
Manufacturing a solar cell with all backside contacts has been extensively explored, particularly for silicon solar cells. This type of solar cell has the advantage of all metallization residing on the back of the cell, giving the opportunity to independently optimize the front and back of the cell for optical and electrical performance, respectively.WhatYouSeeIsWhatYouGet (WYSIWYG) Content Creator window, click the [Media] button to add Video to your course. You would need to have pre-created your video in the following formats:.mpg,.mpeg,.mov,.wmv,.mp3. You will also need to know the dimensions (width and length) of your video. The next step is to complete our Video file upload wizard with the relevant information and then click. Your video is automatically added to your course. To add Flash (.SWF,.FLV) files to your Course: While in the WYSIWYG Content Creator window, click the Flash button to add Flash files to your course. You would need to 2009 Telania, Inc

10 have pre-created your Flash file. You would also need to know the dimensions (width and length) of your Flash file format View Your Flash Video! TIP: We have


PPT to Flash Studio. See the eleap Support website for more information. There are numerous benefits from converting your PowerPoint files to Flash format for web based training. Check our eleap Knowledgebase in our Support Center to learn more Telania, Inc

11 OTHER COURSE FEATURES Collaboration You can easily collaborate with other instructors for ecommerce course development purposes. To add other instructors to collaborate on a course, click on the link in the top left of your course detail page. You can then select an additional instructor and click. Tip: This is an easy way to share course completion data with managers and supervisors in your organization. Certificate Template To create and deploy ecommerce completion certificates, click on the. You can then set the rules for your certificate toSettings option to enter the number of minutes a user needs to spend on each of your lessons (which will total 32 hours). If you only have one lesson, then enter the total 2009 Telania, Inc

12 number of hours (as minutes) and eleap will make sure your user does not circumvent your requirements. Tip: To make the minimum time requirement feature work well, combine it with a quiz assessment. eleap will not allow a user to access the quiz without spending the requisite amount of time on your course Telania, Inc

14 ECOMMERCE CATALOG SETUP & MANAGEMENT Easily manage your eleap ecommerce Catalog site by clicking on the ecommerce tab on your top menu bar. Ecommerce Courses You can manage your current ecommerce courses by clicking on any of


slideshows. Such presentations may include images, animation, text as well as,

Quick Start Guide Installation and Setup Introduction Velaro s live help and survey management system provides an exciting new way to engage your customers and website visitors. While adding any new technology

Adobe Captivate Introduction Learning outcomes: By the end of the course you will be able to: Record a screencast Insert/import PowerPoint slides into a Captivate project Create and edit text clouds and

Student guide to creating and sharing a webfolio This guide includes: An introduction to webfolios Reasons why you might choose to develop a webfolio Instructions on how to create, edit and add content

User Guide Adding content to your Website To add or replace content on your website you will need to log in to your ContentManagement System (Joomla) using your username and password. If you do not already

Accessible Course Design As a course designer you hold a pivotal role in ensuring that Learning Environment is accessible to all users, regardless of their learning needs. It is your content that students

9.1 LESSON 9 Creating a Web Presentation After completing this lesson, you will be able to: Create an agenda slide or home page. Create a hyperlink to a slide. Create a Web presentation with the AutoContent

HOW TO USE THIS GUIDE This guide provides step-by-step instructions for each exercise. Anything that you are supposed to type or select is noted with various types and colors. WHEN YOU SEE THIS Click Help

Dreamweaver and Fireworks MX Integration Brian Hogan This tutorial will take you through the necessary


The Book of Kells (album)

The Book of Kells is a progressive rock album by Iona. Released in 1992.
The Book of Kells, an 8th-century manuscript filled with lush pictures illustrating the Gospels, possibly originating from the monastery at Iona, serves as the album's namesake.

Again the recording process moved round the country for suitable facilities:
Wildlife Studio, Ipswich - (Engineer Nigel Palmer)
Studio 2, Leeds - (Engineer Rob Price)
Kensington Temple Church - (Engineer Nigel Palmer) for the Heavenly Hosts

The recording was remastered for the 2002 release The River Flows: Anthology and later re-released on Open Sky Records as a standalone album.

__NOTOC__

Personnel

Band
 Joanne Hogg - Vocals, Keyboards
 Dave Bainbridge - Keyboards, Guitar, Chimes
 Nick Beggs - Chapman stick, Bass guitar, Small Cymbals
 Terl Bryant - Drums, Percussion
 Dave Fitzgerald - Saxophone, Flageolets, Flute,? ? 1992, Cassette
1992, USA, Forefront Records FFD-3001, Release Date ? ? 1992, CD
2003, UK, Open Sky Records OPENVP2CD, Release Date 3 November 2003, CD

Category:Iona (band) albums
Category:1992 albums
Category:Word Records albums


Stand can happen on Friday night.

Last Stand Placement

Points for 1st – 9/18/27

Points for 2nd – 6/12/18

Points for 3rd – 3/6/9

Skirmish Scoring

Points for Capture

Objectives will award score (for the current skirmish) both on capture, and again on each tick.

This is the method that Edge of the Mists scores objectives, and prevents teams from getting nothing for capturing an objective, but then losing it before the tick scores.

EotM currently awards roughly 3x the objectives tick score on capture. EotM should be normalized to 1x tick score when WvW 2.0 rolls out, so scoring is consistent across all of WvW.

[11:47]

Capturing upgraded objectives is worth higher amounts of Warscore and Participation(individual rewards.)

Holding upgraded objectives is worth higher amounts of Warscore per tick (PPT).

A fully upgraded keep would be worth double the currentcells expressed as a percentage of the total number of nonapoptotic cells counted in each case.\[[@ref17]\]

![Photomicrography showing gingival tissue stained with H and E Stain no (5034 & 39312)](JISP-20-294-g001){#F1}

![Photomicrography showing gingival tissue stained with methyl green-pyronin Stain no (42590 & 45005)](JISP-20-294-g002){#F2}

![Apoptotic cells indicated by arrows in healthy group stained by H and E, respectively (×100)](JISP-20-294-g003){#F3}

![Apoptotic cells indicated by arrows in gingival tissue of chronic periodontitis stained by H and E, respectively (×100)](JISP-20-294-g004){#F4}

![Apoptotic cells indicated by arrows in healthy group stained by methyl green-pyronin, respectively (×100)](JISP-20-294-g005){#F5}

![Apoptotic cells indicated by arrows in gingival tissue of chronic periodontitis by methyl green-pyronin, respectively (×100)](JISP-20-294-g006){#F6}

AI of both the sections was compared and statistical analysis was done using Tukey\'s multiple *post hoc* procedures.

RESULTS {#sec1-3}
=======

The apoptotic cells of gingival epithelium showed certain well-defined features which


included cell shrinkage, condensation and deep eosinophilia of the cytoplasm and pyknotic, round to crescentic or irregular nucleus. Apoptotic cells were clearly tinted with dense methyl green-staining of pyknotic nuclei and dense red pyronin staining in the cytoplasm.\[[@ref18]\]

AI was evaluated in a total of twenty cases, including ten cases each of chronic periodontitis and healthy samples. The mean AI was progressively increased in chronic periodontitis as compared to healthy gingival \[[Table 1](#T1){ref-type="table"}\]. Apoptotic cells were easily distinguishable in MGP stained sections when compared to those stained using H and E and this difference was statistically significant (*P* \< 0.05) between the groups \[[Table 2](#T2){ref-type="table"} and [Graph 1](#G1){ref-type="fig"}\]. Apoptotic cell count in gingival epithelium was higher in chronic periodontitis group compared to the healthy group. When the comparison between(ii) in lung explant culture; (2). To determine the molecular mechanism of TGF-beta pathway-restricted Smad2 and Smad3 in regulating embryonic pulmonary morphodifferentiation in culture using both (i) "loss-of-function" and (ii) "gain-of- function" strategies; (3). To define the biological function of the feedback inhibitory Smad6 and Smad7 proteins during embryonic lung branching morphogenesis in culture. The current study of the molecular embryology will provide new rationales for novel therapeutic strategies to modulate TGF-beta signaling during lung injury and disease.


        }
)}

My purchaseOrderSearchComponentHelper.js
    ({
    getPurchaseOrderList: function(component) {

        var ordrdate = component.get("v.date");

        console.log('ordrdate='+ordrdate);
        var action = component.get("c.getSearchList");

        action.setParams({  "ordrdate" : ordrdate });
    //Set up the callback
    var self = this;
    action.setCallback(this, function(actionResult) {
     //do stuffs;
    });
    $A.enqueueAction(action);
  }
})

My purchaseOrderSearchControllerRe apex class
    @AuraEnabled
  public static List<Purchase_Order__c> getSearchList(Date ordrdate) {

    System.debug('ordrdate='+ordrdate);
}

I am getting ordrdate=null in debug startement. But in console.log statementA few weeks ago, we took to the streets of Florence to spread wildflower seeds guerrilla-style. We tossed our homemade seed “bombs”, seed encapsulated clay balls, into alleys and onto vacant areas – hoping to add more color and beauty to our community.

With the amount of rain that we have been receiving lately, every growing thing has been sprouting up and up toward the sky. Yesterday, retraced our steps to see if our dispersed wildflowers were making progress. There were no full blooms yet; however, we are starting to see small dots of the color purple in Olivia’s yard.

While I traveling through California last month for our One-day Retreat, I stopped by HEATH Ceramics studio for an event called “Shop. Talk. Stitch.” In front of their studio sat


at Princeton agreed with Richardson’s method of cataloging. His system, often referred to as the “Princeton System” relied on whole numbers and minute specifications for classification, resulting in a lengthy cataloging number. And, after many years of service to the Princeton University faculty, staff and students, Richardson was confronted with a group of opposing faculty, who believed that Richardson was not properly performing his duties and that funds were being disposed of inefficiently. A committee was formed to investigate these accusations, of which Richardson was cleared, and it was recommended that the school give the library more funds. This positive opinion did not last, and J.T. Gerould was appointed librarian and the new position of director was created for Richardson without a salary increase. Tensions grew when Richardsonand purified the insert (amino acids 483--765) and added it in increasing amounts to USP4--D1D2 in the Ub-AMC assay ([supplementary Fig S5A](#S1){ref-type="supplementary-material"} online). We observed that the insert slows deubiquitination by USP4--D1D2. To investigate whether this reduction in DUB activity is due to molecular crowding, we repeated the *in trans* inhibition assay with USP4--D1D2 in the presence of either SUMO or BSA ([supplementary Fig S6](#S1){ref-type="supplementary-material"} online). Neither of these reduced DUB activity, confirming that the insert is intrinsically able to inhibit the catalytic activity of USP4.

Competitive inhibition of the USP4 insert
-----------------------------------------

We tested whether USP4--D1D2 would directly interact with the insert. In a surface plasmon resonance (SPR; [Fig 3B](#f3){ref-type="fig"}) experiment, we observed binding of USP4--D1D2 to the insert, with a *K*~d~ of 1.32 μM after equilibrium fitting. This affinity


closely resembled the affinity of USP4--D1D2 for Ub itself (*K*~d~ of 1.39 μM; [Fig 3A](#f3){ref-type="fig"}).

Therefore, we tested whether the insert could compete with Ub for binding to USP4--D1D2, and would therefore bind to the same binding site. In an SPR competition experiment we flowed USP4--D1D2 over a glutathione *S*-transferase (GST)-tagged insert in the presence of increasing amounts of Ub ([Fig 3D](#f3){ref-type="fig"}). We observed decreasing binding of USP4--D1D2 to the GST-insert as the Ub concentration increased. The data could be fitted with a one-site competition binding model with a *K*~i~ of 1.4 μM, showing that the USP4 insert competes with Ub for binding to USP4--D1D2.

Interestingly, the *K*~d~ of intact USP4CD for Ub is only fourfold less, compared to USP4--D1D2 in an isothermal titration calorimetry (ITC) experiment ([Fig 3E](#f3){ref-type="fig"}). Althoughtest whether the Ubl domain is sufficient for binding to the USP4 catalytic domain, we performed the SPR experiment with the purified Ubl domain (amino acids 483--571, [Fig 1A](#f1){ref-type="fig"}) and found a *K*~d~ of 1.36 μM towards USP4--D1D2, which is similar to that for the complete insert ([Fig 3C](#f3){ref-type="fig"}). This suggests that the Ubl domain is the functional part of the insert.

To test whether the Ubl domain can inhibit the DUB activity of USP4, we repeated the *in trans* inhibition assay with USP4--D1D2 in the presence of increasing amounts of the Ubl domain ([supplementary Fig S6](#S1){ref-type="supplementary-material"} online) and found that it provides inhibition equal to the insert. We therefore conclude that the Ubl domain is sufficient to inhibit the DUB activity of USP4, through competitive inhibition of Ub


functions are probably distinct between subfamilies.

The activity of USPs is regulated through an inactive conformation of the catalytic triad, as in USP7, or through a series of blocking loops or a blocking zinc-finger ribbon. USP4 seems to combine the blocking loops and zinc-finger ribbon with a further regulation through the Ubl domain.

Whether Ubl domains provide a common regulation mechanism for the DUB activity of USPs is an interesting question for future research. A second Ubl domain is found within USP4, at its N-terminus. A recent crystal structure (PDB: [3JYU](3JYU), amino acids 139--226) shows that this Ubl domain interacts extensively with the adjacent DUSP (domain in USP) domain (amino acids 27--125). This region of the protein is primarily important for interaction with Sart3 ([@b26]) and hence might not have([Fig 5C](#f5){ref-type="fig"}). Although the activation is modest ([Fig 4A](#f4){ref-type="fig"}), this could be increased by further interactions, as observed in the spliceosome complex.

Regardless of the mechanisms that regulate USP4 activation, it is clear that this type of internal regulation by a Ubl domain allows the creation of an extremely fast response element to external signals.

Methods
=======

For plasmids, cloning, protein preparation and identification, crystallization and structure determination procedures, see [supplementary information](#S1){ref-type="supplementary-material"} online and references.

**Ub-AMC assays.** Quantitative activity (triplicate) and *in trans* inhibition (duplicate) assays or USP modulation assays (triplicate) were performed using Ub-AMC with 10 nM enzyme in 30 μl reaction volume in 384-well plates and preincubated for 15 min at 21° C, for inhibition assays with Ubl insert and with other DUBs for modulation assays. Initial velocities against Ub-AMC concentration


Cerebral blood flow response to hypercapnia in immature fetal sheep.
We have reported recently that the cerebral blood flow (CBF) response to isocapnic hypoxic hypoxia is blunted in fetal sheep in utero at 93 days of gestation (term = 145-150 days), a time of rapid brain differentiation in this species. Cerebral O2 transport fell rather than being maintained, as it is in more mature fetuses. The reason for the blunted response was not clear. We hypothesized that the CBF response to hypercapnia also might be blunted. We studied 10 immature fetal sheep in utero at a mean gestational age of 92 days 24 h after catheters were placed into the superior sagittal sinus, axillary artery, and inferior vena cava. We raised the fetal arterial carbon dioxide tension (PaCO2) bydon't EVER have to leave if I don't want to. But talk about stale energy! Even if it's just walking to check the mail, I MUST get fresh air every day.

2. Videotape yourself.

Put yourself on the spot(light). Sometimes the only way to get a good look at who you really are is by watching yourself. I record video meditations four days a week and make video podcasts with Kelly a few times a month. Watching myself on video gives me fresh perspective and even helps me like myself more. I'm cute!

3. Exercise.

It can be two solid hours of group exercise classes, or it can be a 1 mile walk in the neighborhood. I don't care how intense the workout is, all that matters is that I get my


this bunch to a minimum.

Not News – This is a combination of the Can’t Miss and Skip ‘Em groups. I usually like to read the standard news over breakfast, then save this one for later. It also makes a nice subset to peruse later in the day when I’ve had my fill of the ticker tape feeds. This is another area where Google Reader helped out, because it uses a tagging model that makes it easy to group things in multiple folders.

Great advice for anyone dealing with a mountain of feeds and finite time.disappeared March 8 en route from Kuala Lumpur, Malaysia, to Beijing.

Ten planes were planned to be involved in Sunday's search, the Australian Maritime Safety Authority, which is overseeing the search, said in a statement.

It will still take three to four days for the Australian navy ship, the Ocean Shield, to reach the search zone - an area about 1,150 miles to the west of Australia.

The safety authority said that in addition to the black box detector - the U.S. Navy's Towed Pinger Locator - the ship would be equipped with an unmanned underwater vehicle, as well as other acoustic detection equipment.

Dozens of relatives of passengers on the missing plane flew from Beijing to Kuala Lumpur on Sunday to seek answers from Malaysia's government as to what happened to


objects.

The three objects spotted by the Chinese plane were white, red and orange in color, the Xinhua report said. The missing Boeing 777's exterior was red, white, blue and gray.

Investigators have been puzzled over what happened to Flight 370, with speculation ranging from equipment failure and a botched hijacking to terrorism or an act by one of the pilots.

The latter was fueled by reports that the pilot's home flight simulator had files deleted from it, but Malaysian Defense Minister Hishammuddin Hussein said checks, including one by the FBI, had turned up no new information.

"What I know is that there is nothing sinister from the simulators, but of course that will have to be confirmed by the chief of police," he said.

Newly analyzed satellite data shifted the search zoneHillbillies

Bulworth

Butch Cassidy and the Sundance Kid

Caillou

The Central Park Five

Cheech & Chong’s Up in Smoke

The Conspiracy

Daniel Tiger’s Neighborhood, seasons one-two

Dinosaur Train, season two

Drive Me Crazy

Flashpoint, seasons one-five

The Flintstones

The Flintstones in Viva Rock Vegas

The Game, seasons one-three

How to Marry a Millionaire

Ice Age: The Meltdown

Medium, seasons one-seven

Mister Rogers’ Neighborhood, volume one

Mouse Hunt

My Sister’s Wedding

Notting Hill

Numb3rs, seasons one-six

Odd Squad, season one

The Perfect Storm

The Quiet Man

Reading Rainbow, volume one

The Right Stuff

Rubber

Star Trek: The Motion Picture

Star Trek II: The Wrath of Khan

Star Trek III: The Search for Spock

Star Trek IV: The Voyage Home

Star Trek V: The Final Frontier

Star Trek VI: The Undiscovered Country

Star Trek: Generations

Talladega Nights: The Ballad of Ricky Bobby

Team America: World Police

Tesla: Master of Lightning

Thumbelina

The Very Hungry Caterpillar and Other Stories

Wild Kratts, seasons one-three

Witness

Women Aren’t Funny

WordWorld, season one

Zoboomafoo, season two

July 2

Venus and


Plant Mycobiomes {#s1}
================

Plants do not exist as single entities but should rather be considered to form a complex community with microbes and other organisms where plant tissues form diverse niches for microbes. One major relationship concerns plant-fungal interactions that range from pathogenicity to mutually beneficial symbioses. A balanced state (homeostasis) of these interactions is essential for maintaining the plant as well as an overall healthy state of the environment. Mycorrhizal associations are well-studied examples of root-fungal mutually beneficial symbiosis (Ferlian et al., [@B9]; Gehring and Johnson, [@B14]). The reasons for establishing a mutual symbiosis are only just beginning to be understood at the molecular level ([Mello and Balestrini](https://doi.org/10.3389/fmicb.2018.00216)). Communication between endo- and ecto-mycorrhiza and their respective host plants (Raudaskoski and Kothe, [@B29]; Luginbuehl and Oldroyd, [@B24]; Garcia etal., [@B13], and citations therein) and the effects on phytohormone levels and localized delivery (see Boivin et al., [@B2]; MacLean et al., [@B26]) have been the focus of several recent reports. But even so, a full understanding of these relationships will only be gained by investigating the effects of different strains of the same fungal species ([Sharma et al.](https://doi.org/10.3389/fmicb.2018.01169)).

For roots, as well as above-ground plant tissues, endophytic fungi can be considered as examples of specific co-evolution, provided the term "endophytic" is used in its *sensu strictu* (for a detailed comment, see Kothe and Dudeja, [@B19]). To prove endophytic behavior, Koch\'s postulates need to be observed, and tissue specificity for re-infection may be used as a method to discriminate real endophytes from mere co-occurrence (Wȩżowicz et al., [@B42]; Domka


microbes can be achieved through bioaugmentation strategies, which allow them to create optimal conditions for crop growth under harsh conditions (see Treu and Falandysz, [@B35]) and a reduction in the use of water, fertilizers, and pesticides. The most common plant inhabitants are endophytes that, when properly selected, can be a potent tool against pathogens and abiotic factors (see French, [@B11]). They also support mycorrhizae, which in turn contribute to plant growth and induce tolerance to salinity, pollution, drought, extreme temperatures, elevated CO~2~, etc. (see, e.g., Dhawi et al., [@B5]). The provision of well-selected microbes and the application of appropriate agricultural/forestry practices, both of which are feasible now, can decrease the current intensive use of fertilizers while maintaining an environment that is conducive to human health. Although nowadays theLEGO Worlds is letting the creative juices overflow.

LEGO Worlds is a multiplayer sandbox that lets you build and do pretty much anything. Like creating a LEGO Metal Gear Solid for example.

Bearly Regal is creating Metal Gear Solid in LEGO Worlds on PS4 and you can take a look at the process of making it on imgur.

It looks ace.

LEGO Worlds was released at the beginning of March and it’ll be fun to see what else players come up with now that they have total freedom to create whatever they want.

Have you spotted any weird or wonderful things taking shape in the game? Let us know in the comments.


this message. My four year old son and I spend a lot of time playing co-op video games, specifically, Haunted House, Lego Star Wars and G-Rated L.A. Noire. (That's where you just drive around Los Angeles, obeying traffic laws, and looking at different things.) We also read books together, and ride skateboards. If I were president, I'd come out against bad video games, because more than anything else, I want my son to grow up with good taste in entertainment products.The Federal ZoneCracking the Code of Internal Revenue

by Mitch Modeleski (fourth edition: electronic version)

Note: Mr. Modeleski analyzes Title 26 of the U.S. Code (IRS tax statues) among others to elucidate the subtleties of our complex Republic and it's modern distortions. This book is about much more than tax protest, it's a mini-course in Citizenship and its eternal responsibilities in preventing tyranny. Certain notations are used throughout the text which are absolutely essential
to understanding the concepts presented. dimitri

This book is designed to educate you about federal income
tax law, the Treasury regulations which promulgate that law, and
the various court decisions which have interpreted both. It is
sold with the understanding that the Author and Publisher are not
engaged in rendering legal services of any kind. The right to
author and publish this book,