of polyalkylene glycol, an ether of polyalkylene glycol or an ester of polyalkylene glycol.
The present invention is described in detail below.
The polycarbonate resin used in the composition according to the present invention may be homopolymers or copolymers of a linear or branched thermoplastic aromatic polycarbonate prepared by reacting an aromatic dihydroxy compound or a mixture of the aromatic dihydroxy compound and a small amount of a polyhydroxy compound with phosgene or diester of carbonic acid.
As the aromatic dihydroxy compounds, bis(hydroxyaryl)alkanes such as 2,2-bis(4-hydroxyphenyl)propane(=bisphenol A), 2,2-bis(3,5-dibromo-4-hydroxyphenyl)propane(=tetrabromo-bisphenol A), bis(4-hydroxyphenyl)methane, 1,1-bis(4-hydroxyphenyl)ethane, 2,2-bis(4-hydroxyphenyl)butane, 2,2-bis(4-hydroxyphenyl)octane, 2,2-bis(4-hydroxy-3-methylphenyl)propane, 1,1-bis(3-t-butyl-4-hydroxyphenyl)propane, 2,2-bis(4-hydroxy-3,5-dimethylphenyl)propane, 2,2-bis(3-bromo-4-hydroxyphenyl)propane, 2,2-bis(3,5-dichloro-4-hydroxyphenyl)propane, 2,2-bis(3-phenyl-4-hydroxyphenyl)propane, 2,2-bis(3-cyclohexyl-4-hydroxyphenyl)propane, 1,1-bis(4-hydroxyphenyl)-1-phenyl ethane or bis(4-hydroxyphenyl)diphenylmethane; bis(hydroxyaryl)cycloalkanes such as 1,1-bis(4-hydroxyphenyl)cyclopentane or 1,1-bis(4-hydroxyphenyl)cyclohexane; dihydroxy-diaryl ethers such as 4,4xe2x80x2-dihydroxy-diphenyl ether or 4,4xe2x80x2-dihydroxy-3,3xe2x80x2-dimethyldiphenyl ether; dihydroxy-diaryl sulfides such as 4,4xe2x80x2-dihydroxy-diphenyl sulfide or 4,4xe2x80x2-dihydroxy-3,3xe2x80x2-dimethyldiphenyl sulfide; dihydroxy-diaryl sulfoxides suchin the general formula (III), and R14 and R15 in the general formula (IV) may be the same or different.
These compounds containing cyclic acetal groups may be used singly or in the form of the mixture thereof.
Specific examples of the compound containing cyclic acetal groups represented by the general formula (III) may include 2,2xe2x80x2-ethylene-bis-1,3-dioxolane, 2,2xe2x80x2-trimethylene-bis-1,3-dioxolane, 2,2xe2x80x2-phenylene-bis-1,3-dioxolane, or the like.
Specific examples of the compound containing cyclic acetal groups represented by the general formula (IV) may include 1,3-dioxolane, 2-methyl-1,3-dioxolane, 2-methyl-4-methyl-1,3-dioxolane, 2-pentyl-4-methyl-1,3-dioxolane, 2-n-hexyl-1,3-dioxolane, 2-octyl-4-methyl-1,3-dioxolane, 2-methoxy-1,3-dioxolane, 2-chloromethyl-1,3-dioxolane, 2-bromomethyl-1,3-dioxolane, 2-(2-bromoethyl)-1,3-dioxolane, 2-aminomethyl-1,3-dioxolane, 2-(2-aminoethyl)-1,3-dioxolane, 2-phenyl-4-methyl-1,3-dioxolane, 4-phenyl-1,3-dioxolane, 2-(1-phenylethyl)-1,3-dioxolane, 2-(-phenylethyl)-4-methyl-1,3-dioxolane, 2-benzyl-1,3-dioxolane, 2-benzyl-4-methyl-1,3-dioxolane, 2-benzyl-4,4-dimethyl-1,3-dioxolane, 2-benzyl-4-hydroxymethyl-1,3-dioxolane, 2-{2-(2-methoxyethoxy)ethoxy}-1,3-dioxolane, 2-benzyl-4,4-dimethyl-1,3-dioxane, 4-phenyl-1,3-dioxane, 2-benzyl-5,5-dimethyl-1,3-dioxane, or the like.
The blending amount of the compound containing cyclic acetal group which is represented by the general formula (III) or (IV), is in the range of 0.01 to


or carbonyl group and the sulfone compound represented by the general formula (V), (VI) or (VII) are blended at specified blending ratios with the polycarbonate resin, the resultant polycarbonate resin composition can exhibit no deterioration of its mechanical properties and a very low yellow discoloration upon exposure to an ionizing radiation for sterilization thereof.
(C): The sulfoxide compounds used in the composition according to the present invention, are represented by the following formula (VIII), (IX) or (X):
where R27, R28, R29, R31, R32 and R35 are independently a (C1-C30)alkyl group, a (C3-C30)cycloalkyl group, a (C2-C30)alkenyl group, a (C6-C30)aryl group, a (C6-C30)aryl(C1-C30)alkyl group, a (C6-C30)aryl(C2-C30)alkenyl group, a (C1-C30)acyl(C1-C30)alkyl group, a (C1-C30)alkoxy(C1-C30)alkyl group, a (C6-C30)aryl(C3-C30)alkoxy(C1-C30)alkyl group, a (C6-C30)aryl(C1-C30)alkoxy(C2-C30)alkenyl group, a (C1-C30)alkoxy group, a (C1-C30)alkoxycarbonyl group, a polyethylene-glycol-ether group or a pyridylthe mold-release properties under well-balanced conditions, the blending amount of the said polyalkylene glycol derivative is preferably in the range of 0.05 to 3 parts by weight based on 100 parts by weight of the polycarbonate resin.
In the afore-mentioned especially preferred polycarbonate resin composition, the blending percentage of each of the aromatic compound containing oxy group or carbonyl group, the compound containing cyclic acetal group and the polyalkylene glycol derivative, is preferably in the range of 5 to 90% by weight, more preferably 15 to 80% by weight based on the total weight of these three compounds, though not particularly limited thereto. Thus, by blending the aromatic compound containing oxy group or carbonyl group, the compound containing cyclic acetal group, and the polyalkylene glycol derivative at specified blending


(Grant No. NRF- 2011-0023359, NRF-2018R1D1A1B07046978, and NRF- 2019M3C7A1032262).

**Conflicts of Interest**

No potential conflict of interest relevant to this article was reported.

**Author Contributions**

Conceptualization: Joonho Lee, Sang-Hyuk Lee. Data acquisition: Joonho Lee, Yoonsu Song. Formal analysis: Joonho Lee, Yoonsu Song. Funding: Sang-Hyuk Lee. Supervision: Eunsoo Won, Minji Bang, Sang-Hyuk Lee. Writing−original draft: Joonho Lee, Sang-Hyuk Lee. Writing−review & editing: Joonho Lee, Minji Bang, Sang-Hyuk Lee.

![Regions of Interest of the left hippocampus: (a) head, (b) body, and (c) tail. Orientation is in accordance with radiological convention.](CPN-18-311-f1){#F1}

![(A, B) Correlation between laterality index of the hippocampal tail and early emotional and physical trauma in panic disorder. (C) Correlation between laterality index of the hippocampal tail and anxiety sensitivity for cardiovascular symptoms. LI, laterality index.](CPN-18-311-f2){#F2}

######

Demographic and clinical characteristics of study subjects

  Variable and know that our current state for several reasons is nothing like that terrible period). While it is not horrendous right now, it seems to be just grinding us and grinding us. However I think I see something swirling in the mist ahead. It may not be so pleasant.

There are three major economic powerhouse zones in the world - China, the U.S., and the Eurozone.

China is a big exporter with a deflated currency aimed at aiding this. They do not want to have all of their eggs in one basket anymore (remember it was not long ago that they had no eggs!). So they are trying to create a large middle class that will begin to consume - they want a service industry/tech industry based economy. Like ours!


Analytical performance and workflow evaluation of the Roche E170 modular immunoassay analyzer in a pediatric setting.
To evaluate the analytical performance of the Roche E170 modular analytics immunoassay analyzer and assess its impact on workflow efficiency and ability to consolidate workstations in a pediatric setting. Analytical performance of eleven common immunoassays was assessed. Total imprecision was determined using Roche PreciControl Universal controls, Bio-Rad Lyphochek Immuno Plus, Anemia controls, and a human serum pool. Method comparison was performed with approximately 100 patient specimens. High dose hook effect, sample carryover, and results comparison between the two measuring channels were evaluated. For the workflow study, the time required for sample and reagent handling, instrument preparation, and hands-on time were assessed. Correlation coefficients with existing methods ranged from 0.941 to 0.999. Biases ofQ:

Why do we use phenolphthalein as an acid-base indicator?

It seems that no resource I come across addresses the fact that the pH range for phenolphthalein's color change is around 8.2-10. In other words, it's still colorless at 8.2. Why then, is it claimed that the indicator changes colors when the solution changes from an acid to a base? Wouldn't you want an indicator that changes colors at about pH 7?

A:

If you analyse a titration curve you will immediately notice the pH shooting up near equivalence point. For this reason, there is very little difference to the amount of base added for pH 7 and pH 8 (due to the logarithmic nature of pH). So, it's not entirely accurate but certainly good enough (for strong acid - strong base


been declared Malala Day by former UK Prime Minister Gordon Brown in his role as UN Special Envoy for Global Education. Brown will be holding meetings with senior Pakistani officials today.

He will deliver a petition containing more than a million signatures to President Asif Ali
Zardari, urging him to make education a reality for all Pakistani children, irrespective of gender.

The Hospital said: "Malala continues to make satisfactory progress at the Queen Elizabeth Hospital Birmingham. The medical team supervising her care described her condition as comfortable and stable."

The hospital today released photos of Malala sitting and reading a book.

On October 9, Pakistani Taliban militants, linked to al-Qaeda, shot Malala in the head in her hometown in northwest Pakistan's Swat valley.

In the deserts of Pakistan, Malala is like the finest flowerJones of Australia plays a forehand in her qualifying singles match with Nina Bratchikova of Russia during day two of the Hobart International at Domain Tennis Centre on January 5, 2013 in Hobart, Australia.

Hobart International - Day 2

Mark Metcalfe

Sasha Jones of Australia plays a forehand in her qualifying singles match with Nina Bratchikova of Russia during day two of the Hobart International at Domain Tennis Centre on January 5, 2013 in Hobart, Australia.

Sasha Jones of Australia plays a forehand in her qualifying singles match with Nina Bratchikova of Russia during day two of the Hobart International at Domain Tennis Centre on January 5, 2013 in Hobart, Australia.

Hobart International - Day 2

Mark Metcalfe

Sasha Jones of Australia plays a forehand in her qualifying singles match with Nina Bratchikova of Russia


Thomas Southwood Smith

(Thomas) Southwood Smith (21 December 1788 – 10 December 1861) was an English physician and sanitary reformer.

Early life
Smith's life up to 1812 remains poorly documented. He was born at Martock, Somerset, into a  Baptist family, his parents being William Smith and Caroline Southwood. In 1802 he was sent to the Baptist Academy in Bristol; but he left and broke with his family. He married in 1808, but his wife Anne died in 1812, leaving him two daughters. In this period Smith's contact with William Blake at Crewkerne was significant: Blake put him in touch with John Prior Estlin at Lewin's Mead. Another friend, and Unitarian convert from Baptism who became a physician, was Benjamin Spencer.

Medical man
Smith entered the University of Edinburgh in October 1812, andthe center member is picked up by the drawer member during opening, or when the center member impacts the cabinet member which may occur prior to the time when the drawer member reaches it full extension.
Turning now to other aspects of precision drawer slide technology, there has been a long standing design approach with respect to the configuration of the channel members that make up the precision drawer slide product itself. The channel members, as the name implies, are roughly xe2x80x9cC-Shapedxe2x80x9d and the height and width of the various components of the web and flanges making up the member may vary with the application, the load that is anticipated, and the design envelope that may be available to the manufacturer. With respect to precision drawer slide members; it


trough of the raceway observable changes occur in the configuration of the profile. These changes are inelastic deformations that are caused by the impression of load onto the small contact zone where the ball meets the surface of the raceway. This will actually result in the deformation of the metal at the contact zone causing it to be pushed or mounded until equilibrium is established between the size of the load and the ability of the contact zone to distribute the load.
It has been observed that when the metal is worked in this fashion, there is a corresponding reaction on the part of the flange end extending outwardly (away from the sidewall of the cabinet) such that it tends to xe2x80x9cunwrapxe2x80x9d from its original xe2x80x9cCxe2x80x9d shaped profile. Thistorsional loads to such a degree that the members of the precision drawer slide can be reduced in metal thickness or cantilevered to a greater extent then was previously known to be practical. The precision drawer slide of the present invention comprises two members, one of which is a cabinet member that employs a unique hat section profile to achieve a surprising degree of rigidity and resistance to loadings. The drawer member of the present invention is inner-connectedly related to the cabinet member by means of ball bearings that are oriented through the usage of spaces or retainers, or through other conventional means. However, in the case of the present invention, the actual number of ball bearings necessary to achieve the desired performance level and their longitudinal spacing


In contrast, de novo mutations occurring during spermatogenesis/oocytogenesis cannot be detected in the tissues of the parents, except for in a limited number of germ cells. Trio analyses have revealed that de novo mutations in *SETD1A*, *CHD8*, and other critical variants are associated with an increased risk of multiple psychiatric disorders \[[@CR13]--[@CR17]\]. Large case--control studies have validated these findings regarding *SETD1A* and *CHD8* in patients with schizophrenia and ASD, respectively \[[@CR18], [@CR19]\].Fig. 1De novo or somatic mutations and developmental stage. **a** De novo mutations occur before or during spermatogenesis/oocytogenesis. Mutations in the sperm or oocytes descend to the fertilized egg and are shared among all tissues in the proband. The descendants of the proband will inherit this de novo germline mutation with a probability of 50%. **b** Somaticnot completely identical in one individual. Somatic mutations have also been well characterized as a pathological mechanism associated with cancer \[[@CR20]\], and as an adaptive physiological mechanism associated with somatic rearrangement of immunoglobulin genes \[[@CR21]\]. Cancers are caused by somatic mutations in key-driver genes in a specific tissue, and numerous additional somatic mutations may accrue with advancement. In addition to cancerous tissues, recent genomic studies have systematically identified somatic mutations at the genome-scale in non-cancerous human tissues \[[@CR22]--[@CR26]\]. Furthermore, some mutations originally labeled as germline de novo mutations have subsequently been identified as somatic mutations that occurred after fertilization in the children \[[@CR27]\], or prior to spermatogenesis/oocytogenesis in the parents \[[@CR9]\].

Several human diseases are known to result from somatic mutations \[[@CR28]\], and accumulating evidence indicates that somatic mutations


may explain in part the liability to psychiatric disorders \[[@CR29]--[@CR32]\]. Such mutations can be observed in various tissues during the early developmental period, including peripheral tissues (e.g., blood cells) as well as brain cells (Fig. [1b](#Fig1){ref-type="fig"}). In contrast, somatic mutations that occur following differentiation exist within a limited region of a single tissue type (e.g., brain), and thus can be detected only in that tissue (Fig. [1c](#Fig1){ref-type="fig"}). Somatic mutations occur due to environmental insults, including inflammation and oxidative stress (described below), as well as stochastic changes during development.

While polymorphisms and the variants transmitted from ancestries are inherited genetic factors, the other three mutation types of de novo and somatic mutations illustrated in Fig. [1a--c](#Fig1){ref-type="fig"} are non-inherited genetic factors. Nonetheless, these all four types of germline and somatic variants (mutations) likely have an additive\[[@CR44]\]. With aging, the C\>T fraction decreases, while the cytosine to adenine (C\>A) and T\>C fractions increase in the cortex \[[@CR43], [@CR45]\]. The dentate gyrus neuron is one exception, where the C\>T fraction increases with aging, probably due to neurogenesis \[[@CR45]\]. The C\>A transversion is probably induced by oxidative DNA damage (see below) \[[@CR43], [@CR45]\]. Lodato et al. \[[@CR45]\] inferred that the T\>C increase is linked to fatty-acid oxidation DNA damage.

The observed somatic mutations were enriched in neurodevelopment-related genes and strands undergoing active transcription. The higher length of the neuron-expressed genes \[[@CR49]--[@CR51]\] may be a reason for mutational susceptibility. Somatic mutations in mature neurons likely occur during active transcription \[[@CR44]\], while somatic mutations in fetal neurons are less abundant in the genomic regions with histone marks of fetal


brains and embryonic stem cells \[[@CR43]\]. The genomic regions susceptible to mutation may differ depending on the developmental stage. The bias of somatic mutations toward neurodevelopmental genes in mature neurons is indicative of their relevance to psychiatric disorders.

In a recent study, we explored somatic mutations in human brain tissue from three healthy individuals via WGS at a depth of \~100×. Allele fractions were assayed and validated via target amplicon sequencing (TAS), ranging from 0.5 to 14% in bulk tissue obtained from the cortex, cerebellum, and liver \[[@CR52]\]. The somatic mutations exhibited considerable spatial diversity; some mutations were observed in the brain but not the liver, while others were observed in the cortex but not the cerebellum. In accordance with the findings of previous researchers, we also observed afrom artificial C\>U deamination due to cell lysis during the preparation of single-cell samples \[[@CR48]\], we also observed the same bias for C\>T transition following a WGS analysis of bulk brain tissues, which were free from deamination during cell lysis \[[@CR52]\]. Neurons have a characteristic 5mC at non-CpG sites and a relatively greater amount of 5-hydroxymethylcytosine (5hmC) than other tissues \[[@CR72], [@CR73]\]. Moreover, 5hmC is an intermediate product during active demethylation of 5mC to C, and previous studies have suggested that this process, including base excision repair, is susceptible to mutation \[[@CR74]--[@CR76]\]. However, one study reported that 5hmC was associated with an \~53% decrease in the frequency of C\>T mutations at CpG sites when compared with 5mC \[[@CR77]\]. It is also possible that AID/APOBEC cause in vivo cytosine


research revealed that *ABCC9* is associated with sleep duration \[[@CR138]\], indicating that somatic mutations of this gene may be associated with delusional disorders. Overall, studies of discordant monozygotic twins, particularly when combined with analyses of de novo and somatic mutations, will aid researchers in identifying risk genes for psychiatric disorders.

Technical issues in psychiatric research {#Sec11}
========================================

Several issues must be considered during analyses of somatic mutations in human brain samples: (i) the brain region, (ii) sampling method, (iii) sequencing strategy, (iv) candidate detection, and (v) validation.

(i) Selecting the brain region for analysis {#Sec12}
-------------------------------------------

For most psychiatric disorders, the brain regions directly associated with disease etiology have yet to be identified. Therefore, there are no definitive criteria for selecting the appropriate brain regions for analysis. This is in notable contrast to the2 DM would alone lead to earlier recognition of cases, with the potential to intervene earlier in the disease course. Early diagnosis may prevent long-term complications.\[[@ref3]\]

Diagnosis of type 2 DM is generally based on plasma glucose values, and fasting plasma glucose is a test generally employed for screening of individuals undiagnosed with type 2 DM. A fasting plasma glucose ≥126 mg/dl and a random blood glucose ≥200 mg/dl are considered diagnostic for DM, along with symptoms.\[[@ref3]\]

It is important that dentists understand the association between diabetes and periodontal disease. Uncontrolled diabetes increases the risk of both gingivitis and periodontal disease. In patients with advanced stages of diabetes, periodontal abscess and periodontal attachment loss may occur. While each patient may manifest different signs and symptoms, the following are observed in


may serve as a potential source for screening of blood glucose during routine periodontal examination in populations with an unknown history of DM. This study sheds light on the screening of individuals not suspected of DM, using GCB blood samples. Thus, with minimal cost and time investment for patients and clinicians, dental professionals can play a critical role in supporting their patients' overall health. The technique is safe, easy to perform, and comfortable for the patient.

GCB can provide an acceptable technique for evaluating the blood glucose level. However, the technique to obtain the blood sample from gingival crevices is technique-sensitive, which would limit its application as a clinical practice. Additional studies that refine this technique and use larger sample size are recommended. Future studies should be planned withSelenium sulfide: adjunctive therapy for tinea capitis.
Selenium sulfide lotion used as a shampoo has been shown to be an effective adjunctive agent to griseofulvin in the treatment of tinea capitis. Of 16 children with Trichophyton tonsurans infections 15 had negative fungal cultures at two weeks following a regimen of daily oral griseofulvin and selenium sulfide shampooing twice weekly. All patients treated with griseofulvin alone or in combination with either a bland shampoo or topical clotrimazole had positive cultures not only at the two-week interval but also as long as eight weeks later. In vitro analysis shows selenium sulfide to be sporicidal, correlating well with the in vivo observations. It is postulated that selenium sulfide usage may lessen the chances for spreading of infectious spores to other individuals.


Male mice are more susceptible than females to spontaneous liver cancer and to the induction of liver tumors by a wide variety of carcinogens. This sex difference is a consequence of the opposing effects of sex hormones on hepatocarcinogenesis: androgens promote, and ovarian hormones inhibit, the development of preneoplastic lesions, However, a significant subset of the chemicals found to induce liver tumors in mice by the National Toxicology Program are preferentially active in females. Recent work from our laboratory has led to the identification of a specific locus on Chromosome 17, Hcfl, that abrogates the inhibitory effect of the female hormonal environment on liver tumor development. We will test the hypothesis that Hcfl and chemicals that specifically induce liver tumors in female mice induce common signaling pathways during{
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of what would the doctor say about my condition. The weekend came and I woke up early because I do not want to be late for my appointment. My mom asked me about the reason why am I up early and it is a weekend. I was going to explain myself to her and she laughed. My mom has always been a cool mom for me and I love it. She told me to eat breakfast and wait for her because she still needs to take a bath and change clothes. She added that it would take her an hour.

Finally, after a long hour of waiting, she came downstairs and she brought my older brother with her. I asked my brother if he was coming with us andGeneral, Eric Holder, has put the lie to that. He is working to see laws past to remedy huge civil-rights wrongs. In particular, he lists the many states where convicted criminals permanently lose their ability to participate in democracy. They can’t vote, for the worst example.

Much of America thinks that’s swell, He cited detailed analysis and study proving that doing so dramatically increases recidivism. Meanwhile, many folk figure if you commit a crime and get convicted, there really is no such thing as serving your debt.


5,810,673 to Castleberry (herein “Castleberry-673”), discloses a golf swing improvement device. Castleberry-673 is similar to the functioning of Sawyer-290 in that there are two plates rotatable relative to one another, the upper plate having a foot strap and non-slip surface for securing the user's foot in place. There is a surface engaging means 20 that secures the device to level support surface 30. There is no requirement that the device of Castleberry-673 urge a user's heel in an upward motion during the swinging motion that results in quicker hand speed and increased power at the plate.
U.S. Pat. No. 3,372,930 to Sertich (herein “Sertich-930”), discloses a foot trainer having an adjustable rotation and friction means. As with the aforementioned prior art of record, Sertich-930 comprises two plates rotatable withof nestin are highly dynamic throughout the cell cycle [@pone.0006084-Sahlgren1]. Nestin promotes phosphorylation-dependent disassembly of vimentin IFs during mitosis [@pone.0006084-Chou1], and it interacts with Cdk5/p35 [@pone.0006084-Sahlgren2], a kinase regulating differentiation of neuronal and muscle cells. Downregulation of nestin in neuronal cells activates Cdk5/p35 dependent apoptosis, suggesting that nestin is a survival determinant, protecting neuronal progenitors from stress induced cell death [@pone.0006084-Sahlgren3].

In intial studies on the distribution of nestin in mouse embryo tissue we detected a coincident strong accumulation of GR in nestin positive cells. Therefore, we asked whether this may indicate a structural or even functional relationship. GR is the cellular mediator of hormone regulated stress in the body and a key regulator of growth and differentiation in embryonic tissue, notably the brain, the immune system, bone, cartilage,


black stained sheet is marked. (D) Western blot analysis (WB) indicates the presence of Nes in GR immunoprecipitates derived from the cytoskeleton fraction, but shows no coimmunoprecipitation of GR and tubulin (Tub). (E) GR derived from the cytoskeleton fraction coimmunoprecipitates with HSC70 (E, lane 2); GR precipitated from the supernatant lysis buffer coprecipitates also with HSP90 (E, lane 1).](pone.0006084.g005){#pone-0006084-g005}

Subsequently, we asked whether anchoring of GR to the IF system could be modulated in dependence of nestin. Western blots of total cell lysates revealed a strong nestin signal in the anchoring competent C6D8 and C6K23 cells ([Figure 5A](#pone-0006084-g005){ref-type="fig"}, lanes 1 and 3), whereas only a weak signal was present in total lysates of the IF deficient C6D10 cells ([Figure 5A](#pone-0006084-g005){ref-type="fig"}, lane 2). Immunoprecipitation experiments done with the detergent solublesufficient for cytoplasmic retention [@pone.0006084-Kang1], [@pone.0006084-Davies1]. In addition, overexpression of the glucocorticoid receptor raised the nuclear level of naïve, chaperone associated receptor molecules [@pone.0006084-Martins1], [@pone.0006084-Sanchez1]. These data contradict a direct role of chaperone molecules in cytoplasmic retention of GR.

Our data give evidence that anchoring of GR to nestin/vimentin is related to the maintenance of a high proliferation rate. A first, indirect hint was obtained with mouse embryo fibroblasts. Anchoring of GR in these primary cells was typical of early passages, when the proliferation rate was high. In advanced passages the cells ceased expression of nestin, contained GR in the nucleus, and concomitantly halted proliferation. It suggested a link between nestin expression, anchoring of GR and maintenance of proliferative capacity. Our RNAi experiments corroborate the suggestion. First, suppression of


Atypical manifestations of dengue.
As the spread of dengue and dengue haemorrhagic fever is increasing, atypical manifestations are also on the rise, although they may be under reported because of lack of awareness. This review compiles descriptions of atypical manifestations of dengue, such as dengue encephalitis, dengue myocarditis, dengue hepatitis and dengue cholecystitis.China. We will continue to use our global advantage to create value for our Chinese clients,” BlackRock said in a written response to China Daily.

China suspended the program in 2015 as the country faced mounting pressure from capital outflows. But the renewed foreign interest indicates that the authorities may lift the suspension in the near future.

The recent market correction is not expected to detract from China’s effort to reform its capital market or boost the attractiveness of A-shares to domestic and foreign investors.

The Shenzhen Stock Exchange said on Feb 9 in its 2018-20 development plan that it will reform the current listing requirements for its startup board and will make the exchange more inclusive for high-tech and innovative companies.


Q:

Parsing Expression> to Model?

I wanna parse Expression<Func<Entity, bool>> to a model :
public class Program
{
    static void Main()
    {
        List<Entity> entities = new List<Entity>
        {
            new Entity{ Id = 1, FullName = "Mohammad Dayyan"},
            new Entity{ Id = 2, FullName = "Zahra Ahmadi"},
            new Entity{ Id = 3, FullName = "Milad Ahmadi"},
            new Entity{ Id = 4, FullName = "Ali Dayyan"},
    Q:

Why getting error when updating MongoDb?

I am building backend with MEAN stack, but when I try to update document in the db i am getting an error:
 topUp = function(name, amount, callback) {
    User.updateOne(
        { "name" : name },
        { $set: { "wallet": amount } },
        function(err, results) {
            console.log(results);
            callback();
        });
 };

TypeError: User.updateOne is not a function
But e.g. findOne() works fine:
    User.findOne({


here. But in these last days and weeks many of you have felt this anticipation rising. You have been feeling that something is just around the corner. Something is just outside eluding you at this moment.

You know that so many things are happening behind the scenes. Preparing everything for the moment, for the times where we, as the Ashtar Command, can be a part of this process. There are many of us preparing for this. This is what we came here for.

Many of you are up in our ships as well in your multidimensional selves and in your dream states are with us. You are preparing along with us. Preparing the time for when we can introduce ourselves to the world. The world in that moment will bein the not too far off future we will all be attuned together.

Pease and love be with all of you.

Sources:

eraoflight.com/2017/02/15/ashtar-and-ows-all-of-this-is-happening-now/#more-22473

www.ancientawakenings.org/ Ashtar and One Who Serves: All Of This Is Happening NOWWe are all standing outside of your atmosphere, watching and waiting for the moment to be given, the signal to be given. That we can begin to uncloak our ships. That we can begin to move down. To be a part of what is being called first contact.That time, as “Sananda” has spoken of is nigh. It is fast upon you now. Many of you are feeling a sense of anticipation. Some, even for years here. But in these last days and weeks many of you have felt this anticipation rising. You have been feeling that something is


just around the corner. Something is just outside eluding you at this moment.You know that so many things are happening behind the scenes. Preparing everything for the moment, for the times where we, as the Ashtar Command, can be a part of this process. There are many of us preparing for this. This is what we came here for.Many of you are up in our ships as well in your multidimensional selves and in your dream states are with us. You are preparing along with us. Preparing the time for when we can introduce ourselves to the world. The world in that moment will be transformed beyond your imagination.I tell you now, as “Ashtar” and as “Sananda” looks over, we tell you, you are on the verge nowof the West") movement celebrates its one-year birthday. In these past 12 months, Pegida has organized a series of increasingly large protests, at which protesters chant against Muslims, refugees, and immigrants, whom they refer to as "invaders."

In a recent rally, a Pegida speaker warned that Germany is becoming a "Muslim garbage dump," and lamented that "the concentration camps are unfortunately out of action at the moment." Pegida claims to be anti-Nazi, but its movement has strikingly fascistic tendencies. In fact, Pegida's founder quit after a photo of him dressed like Hitler was leaked.

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The world is witnessing the worst refugee crisis since World War II. The German government said it expects up to 1.5 million refugees to arrive in the country in 2015. In the past several months, as


no acute or chronic disease and no allergic disease with the ISAAC questionnaire \[[@ref12]\]. As a result of the patient selection, three groups were formed of 29 children with mild persistent asthma, 30 children with moderate persistent asthma and 38 healthy control subjects. The subjects ranged in age from 7 to 14 years old. The Ethics Committee of the Gaziantep University Medical Faculty approved this study (Code: 02-2013/76). Informed consent was obtained from each patient who was included in this study, and the study protocol was followed according to the ethical guidelines of the 2014 Declaration of Helsinki.

Laboratory Analysis and Data Collection {#sec2-2}
---------------------------------------

On the first day, all the patients with asthma were applied with the fractional exhaled nitric oxide (FeNO/NIOX, Aerocrine AB, Stockholm, Sweden) measurement and the asthma     }
    },
    { "multi": true },
    function(err,numAffected) {

    }
)

The "query" portion of the .update() statement is making sure that we only even attempt to touch documents which have an empty array in "products.rates". That isn't required, but it does avoid testing the following "update" statement condition on documents where that condition is not true for any array element, and thus makes things a bit faster.
The actual "update" portion applies $pull on the "products" array to remove any of those items where the "inner" "rates" is an empty array. So the "path" within the $pull is actually looking inside the "products" content anyway, so it is relative to that and not to


I wanted to read you a quote of Rick Perry, Texas governor, an interview he did just April 9th with Newsmax. He said, “The men and women in Texas know something now after a decade-plus of our governorship and our policies being implemented by a Republican House, Senate, lieutenant governor and speaker. We’ve kept our tax burden as light as we could and still delivered the services that the people of Texas desire, and we have a regulatory climate that is fair and predictable. I cannot tell you how important is predictability and stability in the regulatory climate.” Your response, Mike Elk?

MIKE ELK: Yeah. The one issue that people that hate regulation go after the most is workplace safety. There was a study released by the GAO lastthe thousands of other students who gave the test but not to the best of their ability? Should they suffer for no fault of theirs? Many students said they were hesitant to speak out publicly but were seeking advice from their coaching class on how to cope with the current situation.

Gautam Puri, vice chairman of Career Launcher, which coaches MBA aspirants, said, “Those who didn’t get to give the test have had their exams rescheduled. But, what has definitely not been taken care of is that many students have not taken the test in the right environment. In a few centres, students weren’t allowed to use the Mark and Review buttons; if you don’t use these two buttons, you end up losing 20-25 minutes and the number of


questions you attempt will be lower by 5-7 questions or around 15%, which is huge in this kind of exam. And these students are unlikely to get another chance.”

CAT 2009 was held at 361 labs in 104 locations spread across 32 cities. Each edition of the test involved the use of over 17,000 computers. "It was therefore a mammoth task being attempted for the first time. We regret the inconvenience caused to candidates due to disruptions experienced in the conduct of the test, particularly in the first three days of testing," the statement from the IIMs said.

But despite the apologies, explanations and the prospect of a re-test for some candidates, many students have reportedly communicated their frustration and grievances to the IIMs and Prometric. Many also said thatspots to No. 16) and the Texas Rangers (dropped 11 spots to No. 19).

This week's voters are Jim Bowden, Eric Karabell, Tim Kurkjian, David Schoenfield and Jayson Stark.

Preseason rankings

Record: 4-2

Preseason ranking: No. 1

Despite a slow start from reigning MVP Kris Bryant (0-for-his-first-13 with six K's), the Cubs won their opening series in St. Louis behind strong pitching, allowing nine runs in three games. They'll be tested at home this week in a three-game series against the Dodgers in a rematch of last year's National League Championship Series. -- Paul Hembekides, ESPN Stats & Information

Record: 3-3

Preseason ranking: No. 2

The reigning American League champs swept the Rangers in their first series of the season, but then dropped three straight in Arizona. The good news is Francisco Lindor has three homers


a 4-0 start -- which made them one of five teams to start 4-0 after losing 100-plus games in the previous season -- but have still gotten largely strong starting pitching so far. Can Byron Buxton stop swinging away and find himself at the plate? Will Brian Dozier return to his 40-homer form from last season? -- Sarah Langs, ESPN Stats & Information

Record: 1-5

Preseason ranking: No. 10

So far, the departure of Edwin Encarnacion has been evident in the Jays' lineup. They've scored more than five runs just once in their opening games against the Orioles and Rays. After both Francisco Liriano and Marco Estrada had rough starts their last time out, Marcus Stroman, Aaron Sanchez and J.A. Happ can't do it alone if the offense doesn't get goingdefined by NGT,” Agarwal said. “The minimum fine for this offence is Rs 50,000. Our teams are carrying out the inspections, which will not end on November 13 but will be ongoing,” he added.

Agarwal further said that he has also ordered all manual sweeping to stop in the city besides implementing other green norms. “Notices are being issued to anybody violating NGT orders. On Friday we have issued a directive to all hospitals, institutions, industries and commercial organizations to follow NGT directions, failing which we will not only levy hefty penalties but stakeholders could also receive summons from the green court,” he warned.

Meanwhile, GNIDA is also undertaking water sprinkling across the city to curb dust pollution. “While two tankers are washing city roads, six tankers are washing the


The actors are gamely delivering their lines in another revival of the world's most shopworn drama.

There's Calgary Flames CEO Ken King informing his city, in sorrow more than anger, that the club will shelve plans for building a new arena and "figure out what the future will look like at some point later."

Standing nearby is NHL commissioner Gary Bettman, striking a familiar passive-aggressive pose used when seeking a handout: "They're going to hang on as long as they can. At least, that's the current view."

Story continues below advertisement

Related: Calgary Flames and Gary Bettman turn up the heat on arena talks

The implication: Nice little hockey town you've got there; be a shame if anything happened to it. This endlessly repeated script needs a re-write. It's as predictable as itgained effective control of CIP and on July 18, 1979, Bouverie replaced a majority of the trustees of CIP.[2] Second, on or about October *281 14, 1980, the trustees of CIP entered into an agreement with Bouverie to merge CIP into Bouverie and to name the surviving entity Pan American Properties, Inc. This merger was effected on January 15, 1981.[3] At no time prior to the merger did CIP seek NMSA's written consent to this plan of action. Defendants did seek NMSA's approval after the fact in a letter of February 24, 1981, see plaintiff's exhibit 4, attachment 4, page 3, but NMSA decided to withhold its approval.

Discussion
I. Before deciding whether the instant actions of CIP and PAP actually amounted to a transfer of interests, this court is


complete integration of the parties' contract, parol evidence is only admissible if the agreement is ambiguous or if it was executed through fraud, duress or mistake. See Shankland v. Mayor, 5 Pet 390, 30 U.S. 930, 8 L.Ed. 166 (1831); Rice v. Rice, 415 A.2d 1378, 1382 (D.C.Ct.App.1980). Because the written language of the instant Partnership Agreement is susceptible of a clear and definite understanding, and neither fraud, duress, nor mistake is alleged, admission of the proffered parol evidence in this case would be improper. See Reynolds v. Reynolds, 415 A.2d 535, 537 (D.C.Ct.App. 1980).
III. Finding that the scope of Section 21.0 does include transfers of interest and having no competent evidence to except the instant transfer from the parties' intended prohibitions, the next issue, and the key_BaseKeyTy, Equatable, Hashable, ExpressibleByIntegerLiteral
{
  override init(_ value: Int) {
    super.init(value)
  }

  convenience init(integerLiteral value: Int) {
    self.init(value)
  }

  func hash(into hasher: inout Hasher) {
    hasher.combine(value)
  }

  var hashValue: Int {
    return value
  }

  static func ==(lhs: TestKeyTy, rhs: TestKeyTy) -> Bool {
    return lhs.value == rhs.value
  }
}

// A variant of TestKeyTy with precise control over hashing.
// This is useful for bucket-level tests.
final class RawTestKeyTy: _BaseKeyTy, Equatable, Hashable
{
  var _hash: Int

  init(value: Int, hashValue: Int) {
    self._hash = hashValue
    super.init(value)
  }

  var hashValue: Int {
    return _hash
  }

  func


}
  return result
}

func _equalsUnorderedWithoutElementIdentity(
  _ lhs: [ExpectedSetElement], _ rhs: [ExpectedSetElement]
) -> Bool {
  func stripIdentity(
    _ list: [ExpectedSetElement]
  ) -> [ExpectedSetElement] {
    return list.map { ExpectedSetElement(value: $0.value) }
  }

  return equalsUnordered(stripIdentity(lhs), stripIdentity(rhs))
}

struct ExpectedDictionaryElement : Comparable, CustomStringConvertible {
  var key: Int
  var value: Int
  var keyIdentity: UInt
  var valueIdentity: UInt

  init(key: Int, value: Int, keyIdentity: UInt = 0, valueIdentity: UInt = 0) {
    self.key = key
    self.value = value
    self.keyIdentity = keyIdentity
    self.valueIdentity = valueIdentity
  }

  var description: String {
    return "(\(key), \(value), \(keyIdentity), \(valueIdentity))"
  }
}

func == (
  lhs: ExpectedDictionaryElement,
  rhs: ExpectedDictionaryElement
)and, says Kennett, ‘seemed to please himself with a prospect of that station.’ He was also disappointed of the rectory of St Clement Danes, which he made no doubt his interest with the Exeter family would secure for him. According to Kennett Fuller's end was hastened by overindulgence in the pleasures of the table: ‘He was a plentiful feeder and at times a liberal drinker, though in small glasses, and his ill habit of body was imputed to Lincoln ale.’ He died at the age of sixty-five, 4 March 1699 – 1700, and was buried in his cathedral, where a mural monument was erected to his memory, with a portrait bust in alto-relievo, and a very laudatory epitaph in latinity of remarkable excellence, the composition of the Rev.


news about the generation poised to replace the retiring baby boomer workforce set.

Deemed sorely lacking in academic and applied skills, the report concluded that "the future is here, and it is ill-prepared."
"This study should serve as an alert to educators, policymakers and those concerned with U.S. economic competitiveness that we may be facing a skills shortage," said Susan R. Meisinger, President and CEO of the Society for Human Resource Management in a statement.

"In a knowledge-based economy, a talented workforce with communication and critical thinking skills is necessary for organizations and the U.S. to be successful."
Forty percent of survey participants said hired high school graduates lacked basic skills in reading comprehension, writing and math.
But, beyond the three fundamental "Rs", employers cited applied skills such as teamwork, critical thinking andQ:

Array in value in input type checkbox?

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      Paul
      Attuck
      paulattuck@yahoo.com
      <input type="checkbox" name="list[]" value="paulattuck@yahoo.com" />

      James
      Bond
      jamesbond@yahoo.com
      <input type="checkbox" name="list[]" value="jamesbond@yahoo.com" />

      Name
      Last
      lastname@yahoo.com
      <input type="checkbox" name="list[]" value="lastname@yahoo.com" />

    <input type="submit" name="submit" value="submit" />
</form>

and if i checked


Below-Ground Attack by the Root Knot Nematode Meloidogyne graminicola Predisposes Rice to Blast Disease.
Magnaporthe oryzae (rice blast) and the root-knot nematode Meloidogyne graminicola are causing two of the most important pathogenic diseases jeopardizing rice production. Here, we show that root-knot nematode infestation on rice roots leads to important above-ground changes in plant immunity gene expression, which is correlated with significantly enhanced susceptibility to blast disease. A detailed metabolic analysis of oxidative stress responses and hormonal balances demonstrates that the above-ground tissues have a disturbed oxidative stress level, with accumulation of H2O2, as well as hormonal disturbances. Moreover, double infection experiments on an oxidative stress mutant and an auxin-deficient rice line indicate that the accumulation of auxin in the above-ground tissue is at least partly responsible for the blast-promotingcharset="utf8" src="https://cdn.datatables.net/buttons/1.5.6/js/buttons.flash.min.js"></script>

    </form>

Jquery
$(document).ready( function () {
  var table = $('#samples').DataTable( {
    "processing": true,
    "serverSide": false,
    "pageLength": -1,
    "lengthMenu": [[100, 250, 500, -1], [100, 250, 500, "All"]],
    ajax: "datatables.php",
    columns: [
      {data: '',
       defaultContent: '0',
       visible: false },
      {data: '',


(CEUS) and elastography have the potential to improve sensitivity and specificity for a variety of neuropathology but also expand the indications for cranial ultrasound. Goal of this paper is to present and discuss CEUS and elastography for neonatal brain imaging.Every single lump is different. Someone here might have had a dog with a lump and have experience with lumps but it does not mean its the same situation for your dog. In my opinion, I'd take her for...

If your worried about safety, there is a harness called the Vestharness. You can put that on the dog and then put the front seatbelt through the harness. (They are made for that, 3 in 1 use) I have a...

I am against it because sadly Theo has seizures and I do not want anything around his neck. I was really referring to the collars that spray citronella into their faces. Before I purchase any device,...

Hi Lorna. Sorry to hear about your cat. You should put posters up with his picture


The subject of using profanity often comes up in my classes. Should I use it? Should I avoid it? The answer is: Fuck if I know! Here’s the deal: Sometimes profanity is absolutely necessary for a joke to work: A little old lady is golfing on the back nine when a tee shot whizzes by . . . → Read More: Is Profanity Necessary in Humor? For every 100 females age 18 and over, there were 95.0 males.

The median income for a household in the village was $38,333, and the median income for a family was $48,929. Males had a median income of $35,375 versus $23,036 for females. The per capita income for the village was $20,323.  About 1.3% of families and 6.6% of the population were below the poverty line, including 3.2% of those under age 18 and 17.6% of those age 65 or over.

Education
Students in public school Pre-Kindergarten through sixth grade attend Cambridge Elementary School in Jeffersonville, VT (318 students).
For grades 7 - 8, public school students attend Lamoille Union Middle School in Hyde Park, VT (274 students).
For grades 9 - 12, public school students attend Lamoille Union High School


its very worst and it worries me a great deal.”

The Speaker applauded the President, saying Trump was “making progress every week” despite the forces determined to take down his administration.

“Trump somehow just keeps grinding forward. He’s making progress every week, he’s getting things done,” said Newt. “Despite everything, I think the Trump system is gradually beginning to really work.”

“I cannot believe the double-standard. I know I should be used to it, but this is beyond the pale of anything I’ve seen,” said Hannity.

“This is not a double-standard, this is a very simple standard,” the Speaker responded. “If you’re the left, you hate Donald J. Trump. If you’re the left, anything you can do to undermine him is ok. And if you’re the left, you automatically ignore scandals nobelieves that we must lull Longshanks into our confidence by neither supporting his decree nor opposing it." "A wise plan." "And how is your father?" "We missed him at the council." "His affairs in France keep him long overdue." "But he sends his greetings, and he says that I speak for all of the Bruces and for Scotland." "(INHALING)" "(FESTIVE MUSIC PLAYING)" "(PEOPLE CHEERING)" "(MUSIC STOPS)" "MAN: it's all over now." " You've dropped your rock." " Test of manhood." "You win." "Call it a test of soldiery, then." "The English won't let us train with weapons, so we train with stones." "The test of a soldier is not in his arm." " It's here." " No." "It's here." "(CROWD GASPING)" "(CROWD LAUGHING)" "Hamish?" "Mmm-hmm." "(CROWD CHATTERING)" "(CROWD


No." "It's fine." "(LAUGHS) I'm not going to steal it." "You remind me of my daughter back home." "Hello, lassie." "(SCREAMS)" "(SCREAMING) No!" "No!" "Keep it quiet, Smythe." "(SHOUTS)" "You bitch!" "(SHOUTING)" "You bitch!" "(SHOUTING)" "(GRUNTING)" "Are you all right?" "All right?" "Come on." " Are you all right?" " Aye." "Are you all right?" " Can you ride?" " Aye." "Come back here, you bastard!" "Raise the alarm!" "Help!" "Meet me at the grove." "Ride!" "SMYTHE:" "They're getting away!" "MAN:" "Go round back!" "(MEN SHOUTING)" "MAN:" "Get her!" "Come on!" "(GRUNTS)" "(SHOUTS)" "You bitch!" "Murron?" "Murron!" "All of you know full well the great pains I've always taken never to be too strict, too rigid with the application of our laws." "And as a consequence, have we"Every man of us is ready to swear loyalty to you." "So let the council swear publicly." "We cannot." "Some scarcely believe you're alive." "Others think you'll pay them Mornay's wages." "So we bid you to Edinburgh." "Meet us two days from now." "Pledge us your pardon, and we'll unite behind you." " Scotland will be one." " One?" "You mean us and you." "No." "I mean this." "It's the pledge of Robert the Bruce." "You do know it's a trap." "Tell him." "I think if the Bruce wanted to kill you, he'd have done it already at Falkirk." " Aye." " I know." "I saw." "Leaving him aside, what about the others?" "Nest of scheming bastards!" "They couldn't even agree on the color of shite!" " It's


man!" "And you're not my father." "You're my son, and you have always known my mind." " You deceived me." " You let yourself be deceived." "In your heart, you always knew what had to happen here." "At last, you know what it means to hate." "Now you're ready to be a king." "My hate will die with you." "William Wallace, you stand in taint of high treason." " Against whom?" " Against your king." "Have you anything to say?" "Never in my whole life did I swear allegiance to him." "It matters not." "He is your king." "Confess, and you may receive a quick death." "Deny, and you must be purified by pain." "Do you confess?" "(EXHALES)" "Then on the morrow, you shall receive your purification." "Studio, Auckland, NZ, Innersong USA
2012	Live in Brazil, Innersong USA
2010	Unity Hours II, Sky Studios, London, Innersong USA
2007 Red Earth Fusion, Innersong, USA
2006	Unity Hours I, Sky TV Studio, London, Innersong USA
2004 Reddish Blossom, songs inspired by Prabhat Samgiit, Bengali love songs, Innersong, USA
2001 	Era Dynamic,* MoreFm Studios, Auckland, NZ, Innersong USA
2001   Magnificence, Outback Studio, Auckland, INnersong USA.
1999 Dancing Divinity, Acoustic Wave, Auckland, NZ, Innersong USA.
1997	Longing,* Q Studio, More Fm Studios Auckland, and Q Studios, Australia, Innersong USA
1996 Sounds of Silence,* More Fm Studio, Auckland, NZ, Innersong, USA
1993	Touched by the Sea,* Innersong, USA.
1993	Beloved, Innersong, USA.
1991 Reign of Love, Acoustic Wave Records, Auckland, NZ.

Group albums
2002	Lotus Beat, with EastranzWest, Visitors Records, NZ.
1989	Waiting – the Album with Turiiya, Jayrem Records, Wellington, NZ
1987


a lower amount of excess air ratio is required in the burning process. Additionally, with high contact surface areas between the fuel and air a lower amount of excess air ratio is required. Opposingly, if the fuel has a greater moisture content or there is less contact surface area between fuel and air during combustion then a larger excess air ratio is required.
As an example, with respect to the burning of natural gas, such has little moisture content, is easy to ignite and mixes completely with air during burning, leading to an excess air ratio of only about 1.08. In the burning of coal, although it has a low moisture content and is easy to ignite, due to its compact form the total contact area between the coalin the incineration of the Taipei municipal combine refuse, in spite of its incompact form the ignition temperature of the combustibles are much like the bagasse, and because of its large percentage of moisture content (about 56%), the excess air ratio requirement increases to 2.0. In the same way, while the wet refuse has been completely dried it is burnt immediately on the grate much in the manner of the bagasse. In this case the excess air ratio is reduced and approaches 1.3, while the combustion temperature is raised.
The higher the combustion temperature, the higher the percentage of energy transformation from steam into mechanical energy and electric energy in an electric generating system operated by steam power. Electrical generation by coal, oil or natural gas is performed by


Q:

Problem in minimizing expression

I am trying to implement bootstrapping (https://en.wikipedia.org/wiki/Bootstrapping_(finance)) of CDS curve. To implement it I am trying to minimize a series of expression. The minimum value of expression will result from certain value of variable. I can easily do it in excel however trying to find a way in mathematica.
I am trying to find value of h1 and h2 in below code using Minimize function to minimize two expression.
'Minimize[Sum[50/10000*1/4*1/4*n*97/100*Exp[-h1*1/4*n], {n, 1, 4}] -
Sum[1/2*1/4*n*97/100*(Exp[-h1*1/4*(n - 1)] - Exp[-h1*1/4*n]), {n, 1, 4}]
&&
Sum[77/10000*1/4*1/4*n*97/100*Exp[-h1*1/4*n], {n, 1, 4}] +
Sum[77/10000*1/4*1/4*n*94/100*Exp[-h2*1/4*n], {n, 5, 8}] -
Sum[1/2*1/4*n*97/100*(Exp[-h1*1/4*(n - 1)] - Exp[-h1*1/4*n]), {n, 1, 4}] +
Sum[1/2*1/4*n*94/100*(Exp[-h1*1/4*(n - 1)] - Exp[-h2*1/4*n]), {n, 5}] +
Sum[1/2*1/4*n*94/100*(Exp[-h2*1/4*(n - 1)] - Exp[-h2*1/4*n]), {n, 6,8}],
{h1, h2}, Reals]'

I get following output(12.6 +/- 1.1 mm) was composed of only the SSP tendon, whereas the posterior half (9.8 +/- 3.2 mm) was composed of both the SSP and ISP tendons. The sulcus was located not at the SSP-ISP interval but slightly posterior to the posterior margin of the SSP tendon (4.3 +/- 2.4 mm). We conclude that (1) there is an overlap between the SSP and ISP tendons identifiable by the facets or the distance from the anterior greater tuberosity and (2) the sulcus is located slightly posterior to the posterior margin of the SSP tendon.


so much better at writing than piano even though I’ve been playing piano twice as long.)

Once I settled (or at least set up a homebase) in San Jose, it seemed like the ideal time to sit down and build the perfect writing space. After all, I had a book deal. I was a professional, and professionals have set aside time and space for their jobs. So last November, spurred by a beautiful desk my boyfriend bought me, I put together the following writing space in our tiny attic room.

My writing loft, in this old house, has beautiful yellow walls and a sloping ceiling that makes it feel cozy. I’ve got a poster of one of my favorite modern paintings, Alex Ruis’s Starry Night overhead because it reminds mevestibular nuclei form part of the very complex integrative processes involved in postural control and gaze stabilization \[[@R131]\].

The neurons of the vestibular nuclei also express NMDA and non-NMDA EAA receptors \[[@R26], [@R49], [@R158]\]. Among other functions, these receptors mediate the main excitatory input to the vestibular nuclei neurons that originates from the primary afferents \[[@R31], [@R115], [@R148]\]. EAA receptors alter their expression in a dynamic manner; for example, NMDA receptors mediate a long-lasting depression that forms a significant part of the mechanism that suppresses the activity of neurons from the vestibular nuclei following labyrinth ablation \[[@R60], [@R130]\]. In addition to the EAA receptors mediating the input from the vestibular periphery, neurons of the vestibular nuclei express a variety of neurotransmitter receptors that mediate the many integrative influences that


these nuclei receive (Fig. **[2](#F2){ref-type="fig"}**). Among these are GABA-A and GABA-B receptors and glycine receptors that show an extensive colocalization with GABA receptors, histamine H~1~, H~2~ and H~3~ receptors \[[@R15]\], serotonine 5HT~1~ and 5HT~2~ receptors \[[@R56]\], adrenergic α2 receptors, but also α1 and β receptors \[[@R124]\], cholinergic muscarinic (mACh) and nicotinic (nACh) receptors in all the vestibular nuclei \[[@R92]\], opioid receptors \[[@R146], [@R147]\], canabinoid CB1 receptors \[[@R132]\], neurotrophin Trk A, B and C receptors (for a review, see \[[@R27]\]) and finally, glucocorticoid receptors.

All these synaptic inputs to the vestibular nuclei participate in the development of various physiological processes and its study have contributed to the knowledge of the integrative physiology of the vestibular nuclei and to the many pathophysiological mechanisms involved in vestibular disorders. Commissural GABAergic inhibition seemsthe basal discharge of vestibular afferent neurons \[[@R25]\].

In the central nervous system, histamine modulates the activity of the second order vestibular neurons, and different effects have been observed depending on the experimental paradigm used. *In vivo* studies using iontophoresis of histamine showed a decrease in the discharge frequency of vestibular nucleus neurons in cats \[[@R76]\]; in contrast, *in vitro* studies using slices of the vestibular nucleus found that histamine produced an increase in the discharge frequency of medial vestibular nucleus (MVN) neurons in rats and guinea pigs \[[@R80]\]. Studies using whole-cell patch recording demonstrated that histamine excited lateral vestibular nucleus (LVN) neurons by activation of postsynaptic H~2~ receptors \[[@R168]\]. The MVN is mainly involved in both eye and head control, particularly in the horizontal plane, whereas LVN seems


without the addictive potential of amphetamines.

The application of dopamine (0.1-1 mM) and D1 and D2 agonists induced a dose-dependent and reversible decline in the resting discharge frequency of vestibular afferents in the isolated frog vestibule \[[@R6]\]. The responses of afferent neurons to EAA agonists were inhibited by D1 and D2 agonists, implicating both subtypes of dopamine receptors in the modulation of both ionotropic and metabotropic glutamate receptors. The results obtained suggest that dopamine may interact with both D1 and D2 receptor subtypes that are most likely located postsynaptically on the afferent neurons, where they may form part of the efferent control of vestibular input \[[@R6]\]. These findings coincide with those of previous studies that indicate the participation of catecholamines in vestibular neurotransmission \[[@R47]\] and contribute to understanding theone drug, 3,4-diaminopyridine, a blocker of voltage-activated K^+^ channels (Kv1 family with six transmembrane segments in the alpha subunit), has been used successfully for the management of downbeat nystagmus \[[@R143]\]. In controlled studies against placebo, it was demonstrated that 3,4-diaminopyridine produced a significant control of the nystagmus that appears in patients with type 2 (EA2) episodic ataxia \[[@R144]\]. The rationale behind the study was that potassium channel blockers presumably increase the excitability of cerebellar Purkinje cells, thereby augmenting the inhibitory influence of these cells on vestibular and cerebellar nuclei \[[@R48], [@R70]\]. On the basis of these results, it has been proposed that aminopyridines could have abundant utility in diverse oculomotor disorders and in disorders of cerebellar origin \[[@R145]\].

Our research group has generated evidence that low threshold voltage-activated potassium


nodes visualization connectivity, the integration approach of bounding cylinder\[[@ref31]\] and curve interpolation\[[@ref32]\] are proposed and implemented as shown in [Figure 3](#F3){ref-type="fig"}.

![Proposed Integration approach of bounding cylinder and curve interpolation for extending the series of inter-disconnected cylinders.](NRR-7-1637-g003){#F3}

The steps involved in this study are as following:

Step 1: The series of disconnected neuron morphology are bounded by another (bigger) cylinder.

Step 2: The curve interpolation points are calculated between two endpoints of bounding but adjacent cylinders.

Step 3: Curves are then fitted by interconnecting predetermined control points between bounding cylinders for wrapping the neuron segment to produce smoother connection and effective realism.

### The bounding cylinder model {#sec3-1}

The model employs the use of cylinder containing the disjointed neural objects defined by enclosing the surface of the neuron morphology connection. This technique uses the geometricradius: The accessible radius locator\'s bounding radius is defined as if a cylinder is constructed using the locating position\'s normal as the cylinder axis, and the satisfactory accessible height as the cylinder height, the accessible radius locator\'s bounding radius is the maximal radius the cylinder can be constructed without interface with the work piece geometry. The locator\'s bounding radius is total additional length of neuron\'s radius (RID(n)) as illustrated in [Figure 5](#F5){ref-type="fig"}.Figure 5Illustration of locator\'s bounding radius (RL), the radius of cylinder bounding the neuron segment (also known as locator).(3)Locator\'s curve interpolation: From the above definitions, and at a given locating position, a cylinder can be constructed using the accessible height locator\'s bounding height and the accessible radius locator\'s bounding radius. This cylinder illustrates the volume in three-dimension


compute the intensity at a vertex, it is necessary to know the unit normal vector at the vertex. Since each vertex may belong to many polygons, first, Newell\'s formula\[[@ref37]\] (Equation 1) is used to calculate the unit normal for each polygon containing the vertex (Ron Goldman).

![](NRR-7-1637-g009.jpg)

Then, the unit normal vector is calculated by averaging the unit normal of the polygons containing the vertex:

![](NRR-7-1637-g010.jpg)

Finally, equation 3 is applied to compute the intensity at the vertex.

![](NRR-7-1637-g011.jpg)

IMPLEMENTATION AND RESULTS {#sec1-4}
==========================

The developed prototype is presented in this section for reconstructing neuron morphological model from digitalized neuron data. The whole process is automated but it has also been adapted to be dynamically manipulated by the user.

After responding correctly to the interface, three-dimensional scene is loaded using OpenGL for previewing the representation neuron. OpenGLversus composite alternatives. The alloys are used in extrusions, forgings, sheet and plate applications across aircraft structures, including airplane wings and fuselage elements.

"Alcoa's expansion strengthens Indiana's reputation of manufacturing excellence," said Governor Mitch Daniels. "We are grateful that this global manufacturing leader continues to find the Hoosier State the most advantageous state for growth."

"The demand we are seeing for aluminum lithium is an excellent example of the Alcoa technical advantage in action and is the result of our continued leadership in aerospace alloy development across our Alcoa aerospace businesses," said Eric Roegner, president of Alcoa Forged and Extruded Products. "When completed, our Lafayette aluminum lithium facility will be the premier operation in the world, capable of making the widest breadth of products in the most efficient manner."

In a


I learned to embroider when I was a kid, when everyone was really into cross stitch (remember the '80s?). Eventually, I migrated to surface embroidery, teaching myself with whatever I could get my hands on...read more

I learned to embroider when I was a kid, when everyone was really into cross stitch (remember the '80s?). Eventually, I migrated to surface embroidery, teaching myself with whatever I could get my hands on...read more

Goldwork Embroidery Book Winner!

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We have a winner for Mary Brown’s Goldwork Embroidery: Designs & Projects!

Goldwork Embroidery: Designs & Projects is a technique and project book chockfull of beautiful goldwork embroidery projects and instructional material. If you’re interested in goldwork, it’ll make a nice addition to your stitching library!

The winner of last week’s give-away of Goldwork Embroidery: Designs &worry about small leftover bits. They can be used (successfully!) as glittery chips–sort of like sewing on beads. Check Mary’s archives–surely there is something there to help you.

Thank you all and of course a BIG thanks to Mary! It was really a shock when I saw my name and I’m really looking forward to browsing through the book. I am definitely planning on making a project. (and if it turns out beautiful, i would love to share it here… we’ll see)
Thanks again!

G’day Mary, Another happy ‘customer’. Good on you Mary…and congratulations Sabrina. Your comment easily points out the rightness of this book acquiring you. Some books are kindred spirits and you’ll find this one in kind. It will treat you well.
Cheers, Kath

I just received the book (my book,


by the thought of being pure rage alone. And so we find outlets for our instincts that will not upset the delicate balance of civilization. We create weevil fight clubs. We live our lives at the intersection of what classically has been referred to as the flesh and the soul.

And yet it seems that however much pain and angst and regret accompanies such existence, we really would not want to have it any other way.used as structural strengthening agents in earlier studies on composite silica aerogels. These composite aerogels are associated with substantial dust release, as relatively macroscopic structural strengthening agents are not dimensionally compatible with the nanoscale silica gel skeleton. The above two strategies will also be used in combination to better improve the mechanical properties of silica aerogels \[[@B30-polymers-12-00807]\]. More recently, conformal coating of the silica gel skeleton with a polymer \[[@B31-polymers-12-00807]\] and the construction of a nanoscale interpenetrating network (IPN) \[[@B32-polymers-12-00807],[@B33-polymers-12-00807],[@B34-polymers-12-00807]\] have been proposed. The conformal polymer coating method strengthens the gel skeleton and preserves the mesopores of silica aerogels. However, the micropores in the silica gel skeleton are susceptible to being filled by the polymer, which leads to an increase in density and a decrease in the surface


was initially varied at 1.7, 3.4, 5.1 and 6.8 mL. Silica alcosols were formed by adding 2 mL dilute ammonia (0.1 mol L^−1^) to the mixed solution. These silica aclosols were labeled SA-1, SA-2, SA-3, and SA-4, according to the concentration of TEOS (the volume fraction of TEOS by adding volume is 6.0%, 11.4%, 16.2%, and 20.5% respectively). In an ice-water bath, three BC wet gels (20 × 20 × 1 mm) were immersed in the alcosols and stirred consistently. The BC wet gel was allowed to soak for a variable period of time to determine the optimal soaking period. The samples were removed from the silica alcosols, dried at 80 °C for 1 h, their average weight was measured. The overall time period range and the numbermicrostructure to the matrix to promote the diffusion of the silica alcosols and the subsequent gelation in situ. Consequently, a soaking period of 3 h was selected to ensure that the silica nanoparticles and precursor were fully diffused in the BC matrix. Additionally, the content of silica in composite aerogels and the density of these samples gradually increased with increasing precursor concentration ([Table 1](#polymers-12-00807-t001){ref-type="table"}), indicating that the diffusion of silica alcosols was effective and continued to occur at higher concentrations.

3.2. Microstructure of the Aerogels {#sec3dot2-polymers-12-00807}
-----------------------------------

The scanning electron microscopy (SEM) images of the composite aerogels with varying concentrations of TEOS are given in [Figure 3](#polymers-12-00807-f003){ref-type="fig"}. A silica skeleton formed more effectively in the web-like BC matrix at increased concentrations of the precursor TEOS. Sample CA-1 had the lowest TEOS


machine-gun a German plane while trying to keep his sketchbook clamped between his knees.

What he saw up in the clouds, as he and his pilot stared at death head-on, often affected him so powerfully that sometimes he would start painting as soon as possible after getting back on the ground, while the colors and light effects he had seen were still fresh in his mind’s eye.

The paintings Farré produced were quite varied, and don’t fit neatly into a single category. Some of the images would not look at all out of place hanging next to a piece by Childe Hassam or Camille Pissarro––all sparkling tones and azure skies. Others are strikingly, violently different, featuring deep blacks and intense flashes of red, green, and yellow, symbolizing things like incendiaryout of the gameplan.? He's always liable to
grab that short yardage TD but you just don't know when or where they'll
happen.

RB Jerald  Moore (FA)? Things change quickly in this league.? A few  weeks
ago, Moore looked to be the #1 RB.? Now he's unemployed.

RB Darnell  Autry (Phi)?? I'd expect that Chris Warren will cut into his
time when they return.

RB Jamel  White (Cle)? Travis Prentice carried the load while White watched
this week.

RB Brad  Hoover (Car)? He came back to reality this week.? On top of  that,
it looks like his days may be numbered as Tshimanga Biakabutuka looks to  try
and return this week.

?

WRs Moving  Down

WR Herman  Moore (Det)?? Moore suffered?a


the effect of the bilateral intra-BLA infusion of NE with the different doses of NE (0.1, 0.3, or 1.0 μg/0.2 μl) immediately after training induced change in phospho-GluR1 and total GluR1 levels. All results represent mean ± SEM. \**P* \< 0.05, \*\**P* \< 0.01, vs. vehicle group.](fnbeh-13-00043-g0003){#F3}

Meanwhile, as shown in [Figure 3B](#F3){ref-type="fig"}, Ser831 phosphorylation of GluR1 was decreased in the 0.3 μg and 1.0 μg NE groups but increased in the 0.1 μg NE group (*F*~(3,12)~ = 27.479, *P* \< 0.001; 0.1 μg NE, *P* = 0.003; 0.3 μg NE, *P* = 0.003; 1.0 μg NE, *P* = 0.001, LSD-t after one-way ANOVA). Ser845 phosphorylation of GluR1 was decreased in the 0.3 μg NE group (*F*~(3,12)~ = 27.838, *P* \< 0.001; 0.3 μg NE, *P* \< 0.001, LSD-t0.001), a significant effect of NE in the contextual and cue memory retention test (context: NE: *F*~(1,24)~ = 4.727, *P* = 0.041; cue: *F*~(1,\ 24)~ = 14.160, *P* = 0.001), and a significant interaction between these two factors in the contextual and cue memory retention test (context: *F*~(1,\ 24)~ = 8.535, *P* = 0.008; *F*~(1,24)~ = 19.372, *P* \< 0.001). KN-93 not only induced contextual memory retention impairment when administered alone but also blocked PTSD-like memory impairments induced by immediate post-training intra-BLA infusion of NE (context: *F*~(3,21)~ = 4.708, *P* = 0.011; saline + NE vs. KN-93 + NE, *P* = 0.386, LSD-t after one-way ANOVA; cue: *F*~(3,21)~ = 18.786, *P* \< 0.001; saline + NE vs. KN-93 + NE, *P* \< 0.001, LSD-t after one-way ANOVA).

We next


the fan themselves. What starts off simply as a sweet gesture, turns into an extremely powerful story:

Would you consider buying an Adidas product after seeing this? I know that they have now entered my own consciousness through this campaign.

Great companies and organizations will learn how to evoke this emotion.

Concluding Thoughts

It is easy to say that technology has dehumanized our society, but I would argue that it can actually have the opposite effect. We can now connect to people in a way that is much easier than in previous generations, and help to build relationships that probably couldn’t exist before. There is also the ability to further the existing relationships through the use of social media. Face-to-face is always better, but the opportunity doesn’t always exist.

I love this MarcQ:

Geocoder, get country in Android, getFromLocation zero results

I need to get the country the user is in to display certain information, when the user travels abroad.
Many methods to determine the country required a sim card, but this way didn't. So this is what i use (with a few try, catchs)
Geocoder myLocation = new Geocoder(HomeActivity.this);
myList = myLocation.getFromLocation(gps.getLatitude(), gps.getLongitude(), 1);
String country = myList.get(0).getCountryName();
Log.d(TAG, country);

Most of the time this is working. However, sometimes the list returns zero results. For example the lng lat, 31.7823555,35.2991956, returns zero.
I also tried using a http request to google api, like this
http://maps.googleapis.com/maps/api/geocode/json?latlng=31.7823555,35.2991956&sensor=true

but it also returned zero.
This should be quite an easy thing to determine, which country the phone is in. Is there a better way. How can I get around this problem of zero results?
Thanks
EDITED
I


[@pone.0009665-Saito1]--[@pone.0009665-Zhang1]. The last member of this protein family, MBD4, is a thymine glycosylase primarily involved in DNA repair [@pone.0009665-Hendrich2].

The involvement of MBD proteins in gene imprinting [@pone.0009665-Delaval1], X inactivation [@pone.0009665-Barr1], and transcriptional silencing of genes possessing hypermethylated CpG islands in cancer cells [@pone.0009665-Esteller1], [@pone.0009665-Baylin1] is now well documented. However, in contrast to the situation observed for DNMT-deficient mice, which either fail to develop or else die shortly after birth [@pone.0009665-Jaenisch1], the loss of MBD proteins, with the exception of MBD3, does not result in dramatic phenotypes [@pone.0009665-Klose1], suggesting that MBD proteins deficiency causes subtle gene-expression changes.

Although the involvement of MBD proteins in gene silencing is well established, new facets regarding the links between DNA methylation, MBD proteins and gene transcription are emerging. For instance, it has been reportedand the breast cancer cells lines [@pone.0009665-Martin1], [@pone.0009665-Metivier2]. Experimental evidences are also in favour of a role of DNA methylation in the repression of *pS2* transcription. In the ERα-rich MCF7 cells, *pS2* is unmethylated and transcriptionally active while in the ERα-negative MDA MB231 cell line the 5′ end of *pS2* (nt positions −665 to +17) is fully methylated and the *pS2* gene is silenced, [@pone.0009665-Metivier2]. We have extended this analysis to the down stream region of *pS2* promoter, since it had been suggested that DNA methylation of the regions adjacent to a promoter region may affect transcription [@pone.0009665-Auriol1], [@pone.0009665-Zinn1], [@pone.0009665-Renaud1].

The methylation status of the 5′ end of *pS2*, from nt positions −464 to +294, was investigated in MCF7 cells expressing *pS2* at a high level and MDA MB231


min. PCR amplification was then performed under the following conditions: 30 cycles, 30 s denaturation at 94°C, 1 min annealing at 55°C and 1.5 min extension at 72°C. PCR products were analyzed on a 2% agarose gel and quantified. The ratio between *pS2* and *β-actin* signals was then determined.

Real-time RT-PCR were also carried out to quantify *pS2* mRNA using LightCycler® RNA Master SYBR Green I One-Step RT-PCR mix on a LightCycler® 2.0 system according to the manufacturer\'s instructions (Roche). *β-actin* mRNA was used as a reference. The primers sequences used for reverse-transcription-PCR are available in Supplemental [Table S1](#pone.0009665.s002){ref-type="supplementary-material"}.

*MBD2* mRNA was quantified by competitive quantitative RT-PCR as previously described [@pone.0009665-Billard1].

Supporting Information {#s5}
======================

######

MBD2 siRNA treatments, supplementary data. (A) MBD2 expression in MBD2 siRNA transfected cells. Bar chart representing theCryopreservation: in vitro results in rat pancreatic islets.
Cryopreservation is an effective method of islet storage and may facilitate clinical trials of islet transplantation. It was the aim of the present study to evaluate the in vitro viability of cryopreserved rat islets, including the response to nonglucose secretagogues and glucose oxidation. After pancreatic digestion via intraductal injection of collagenase, 75- to 200-micron Wistar rat islets were handpicked and cultured in RPMI 1640 (glucose 11.1 mmol/L) and randomized into two groups: control (cultured 20 to 24 hours at 37 degrees C) and cryopreserved (after 20 to 24 hours of culture at 37 degrees C, islets were cryopreserved according to Rajotte's protocol: freezing velocity, -0.25 degree C/min; thawing velocity, 200 degrees C/min). In the two groups, we evaluated recovery, insulin content


Tour de Ruhr

Tour de Ruhr  is a German television miniseries with six episodes.

See also
List of German television series

External links

Category:1980s German television series
Category:1981 German television series debuts
Category:1981 German television series endings
Category:Television shows set in North Rhine-Westphalia
Category:German-language television programs
Category:Das Erste television seriescases of primary TNBCs were further subdivided into medullary, metaplastic, apocrine, and invasive ductal carcinomas of no special type (IDC-NST). Immunohistochemistry for GHRH-R was performed on paraffin sections and the staining results were assessed semiquantitatively as negative, low expression, moderate, and high expression. Of the 134 TNBCs, 85 were classified as IDC-NST, 25 as metaplastic, 16 as medullary, and 8 as apocrine carcinoma. Overall, positive reaction for GHRH-R was seen in 77 (57%) of tumors including 66 (77.6%) of IDC-NST. All medullary carcinomas were negative for GHRH-R and, with the exception of 1 case with low expression, none of the metaplastic carcinomas expressed GHRH-R (P<0.005). A considerable number of TNBCs are positive for GHRH-R as a predictor of potential response to anti-GHRH-R treatment. This expression however, varies considerably


there kicking our ass too.

so my opinion that obama is over talking and kissing ass is the right step for now. disarmment can come later.

i see it kind of like tom brady can throw great but not accomplish a thing if he is flat on his back. we are on our back because our last pres pissed off the offensive line so badly they wanted to see us on our back and laugh the whole time. so BHO is over recruiting.

you think we can take it on alone?

lastly, this has everything to do with GWB. everything. these problems didn't arise since january. they have been going on with n korea for the past decade. and the original txt of this thread was about why we were so quickto go to iraq over wmd's when someone else had them right in front of our faces. i find it irritating that you say, "any problem about bush's foreign policy is falling upon deaf ears". i'll put that in my folder and post it up when the imminent cataclismic financial catrasrophe that your type say BHO is causing strikes and we are paying for it in 10 years. I'll be all-it's ________________ problem. What is________gonna do about it. Freaking great logic.

maybe obama should have put on his superman cape and carried the missile to safety resting in the iraqi desert, while the crowds cheered.

Article [I.]
Congress shall make no law respecting an establishment of religion, or prohibiting the free exercise thereof; or abridging the freedom of speech, or of


Q:

Loading XML is VERY slow

I inherited a data-storage which was using simple text-files to save documents.
Documents had some attributes (date, title, and text), and these were encoded in a filename: <date>-<title>.txt, with the body of the file being the text.
However in reality Documents in the system have many more attributes, and even more again were proposed to be added.
It seemed logical to switch to an XML format, and I have done so, with each document now encoded in it's own XML file.
However, reading the files in from XML is now RIDICULOUSLY slow! (Where 2000 articles in the .txt format took seconds, now 2000 articles in the .xml format takes more than 10 minutes).
I WAS using a DOM parser, and after I discovered how slow the reading was, I   private ArticleElement currentElement;
        private final StringBuilder builder = new StringBuilder();

        public Article getArticle() {
            return new Article(uri, source, author, articleDatetime, processedDatetime, title, text);
        }

        /** Receive notification of the start of an element. */
        public void startElement(String uri, String localName, String qName, Attributes attributes) {
            if (builder.length() != 0) {
                throw new RuntimeException(new


             if (element.name.equals(qName)) {
                    return element;
                }
            }
            return null;
        }
    }

A:

Reading data from an unbuffered stream could explain these performance problems. This is not directly related to the change from text to XML but maybe by chance your new implementation doesn't use a BufferedInputStream anymore.

Follwing that path, in detail,Being obese or overweight during pregnancy can result in serious health problems for the mother and child. Obstetricians are often reluctant to recommend restricted weight gain for pregnant women due to safety concerns for the baby and lack of time and tools to safely guide women in their weight control efforts.

A new Northwestern Medicine study shows with proper nutrition guidance it is safe and feasible to restrict weight gain in obese and overweight pregnant women. The obese and overweight women in the study gained five pounds less during their pregnancy than those in the control group. Their babies were born in the normal weight range.

The approach included nutritional counseling on a healthy diet and lifestyle as supported by a commercially available smartphone diet app, with ongoing coaching via


women and don't address prenatal energy and nutrient needs, the authors said. Most commercial apps are designed to support weight loss. During pregnancy, weight gain is anticipated and appropriate, but it should be curtailed in overweight and obese women.

"MOMFIT demonstrates the feasibility of counseling pregnant women in healthy diet and lifestyle behaviors through nutrition coaching using modern technology," Van Horn said. "Applying this approach in a clinical setting could help women achieve recommended weight-gain goals during pregnancy and improve postpartum lifestyle behaviors for the whole family."

One unusual outcome of the trial was a higher rate of cesarean sections for the women in the intervention group. Researchers are investigating possible contributors to this finding.

advertisement

Will MOMFIT kids have less risk of developing obesity?

"The next big question is whether the childrenhelp these children lower their risk of obesity.

Rebooting the whole family's diet

The study's goal was not weight loss. "Weight loss during pregnancy is not encouraged. Rather, we aimed for controlled weight gain by developing healthy diet habits and increasing physical activity that could be sustained long term.

"The overarching goal of MOMFIT was to help the mom make these changes while she was still pregnant, a time when many women are more motivated to do what is right for their babies, and then maintain these new behaviors and become a role model for the family and better informed about how to feed them," Van Horn said.

"The perpetuation of obesity is a never-ending cycle. We're attempting to interrupt that cycle and successfully influence the risk for developing pediatric obesity starting


to minimize the number of moves necessary to homogenize the string, we wish to maximize the number of $u'$ such that every $s'$ has been moved elsewhere. The $u'$s where the $s'$s have not been moved elsewhere must together contain a $s'$ for every $s \in S$, so they must for a hitting set. Moreover, any such hitting set may serve as the ending locations of the $s'$s, by moving each $s$ to the $u$ which hits it.
Thus, the number of moves to homogenize this string is equal to $\sum |s| + |H^*|$, where $H^*$ is the minimum hitting set.

Since minimum hitting set is NP-Hard, optimally homogenizing a string is as well. Since the moves form a witness, it is NP-Complete.

         +----+                 +--------+

The attributes for each class are declared as follows:

ChapterName

Name

Catalog

Category

Problem:
What I want to check is if a customer has any books with duplicate chapter names, that also belong to a specific category in catalog.
I haven't managed to wrap my head around the logic. What I have so far is:
context Shop
self.customers.books->select(cubks | cubks =
  self.catalogs.books->select(cabks | cabks = cubks)->first())

...Which should find the books from the catalog which a customer has.
Question: How can I add further constraints to solve the problem above?
Also. I am using Eclipse, EMF, and the OCL console from within Eclipse.

A:

context Shop::checkForDuplicates(catalog:Catalog)
post: result =
     self.customer.books->flatten()->select(book|


x.LocationID == 5).Count();
        int PTStop =  db.Jobs.Where(x => x.Status == "Stopped" && x.LocationID == 6).Count();
        int SPStop =  db.Jobs.Where(x => x.Status == "Stopped" && x.LocationID == 7).Count();

    }

i then want in the home controller to initialise the job controller and grab the individual variables from the stopped() method, like below
 ViewBag.HBAStopped = j.Stopped();

how do i add the HBAStop variable to the viewbag? i can get around all this by making them into return methods each but this equals to about 30 methods and seems a bit overkill and untidy. I tried various ways with no success, with the return methods being the only option at the moment
i can providecolor but it is still safe to consume.

Conventional peanut butter has a longer shelf life than unprocessed, natural peanut butter. If you open a jar of peanut butter that has been stored in the pantry, refrigeration is recommended to retain flavor and prevent oil separation. If it develops an off color, odor or appearance it should be discarded.

Canned beans have a long shelf life in the pantry. When opened, transfer any leftover beans from the metal can to a glass or plastic storage container to retain their flavor and appearance. And of course, discard any food from cans that are rusted, dented, leaking or bulging.

For sauces and stews, dried herbs can’t be beat. For the most flavor and nutritional benefits, toss out any herbs older than three years.


Bernie Ecclestone has been told he must make a better job of selling Formula One by leading figures hosting this Sunday’s US Grand Prix in Texas.

This week the sport travels to Austin in crisis, with the futures of Caterham and Marussia in the balance, and other teams close to the wall. Pressure is mounting on Ecclestone, the sport’s chief executive and commercial rights holder, to take note, with the message from Mario Andretti, the official ambassador for the race in Austin, and Bobby Epstein, the co-founder of the Circuit of the Americas (Cota), that F1 needs to “loosen up a bit” and “make the sport about personalities”.

Caterham went into administration on Friday and have been given special dispensation not to take part in the next two races asof [US] PGA golfers, who have got really close to their fans.”

Jason Dial, the president of Cota, also feels Formula One should make a greater effort to involve its fan base. “I’d like to see F1 taken off the track and be more about engagement. There is real upside in the brand really growing, in terms of accessibility and digital social engagement. I think these type of things could really move the needle. From a business standpoint I want to engage our fans, and I want to build the fan base. I want to make it younger. I want to grow the pie. That’s what I’m focusing on.

“From a product-offering standpoint, accessibility is something that really plays well in the US market. Fans love to be close to


of this year’s engines has been a major factor in the crisis.

As Graeme Lowdon, the president of Marussia put it just days before his team joined Caterham in administration: “The current recipe, in terms of sporting and technical regulations, has produced a sport that nobody can afford.”= Request;
Elapsed time is 0.019755 seconds.

A:

This solution expands on Marc's answer. Use repmat to initialize an array of RequestH objects and then use a loop to create the desired objects:
>> a = repmat(RequestH,10000,1);tic,for i=1:10000 a(i)=RequestH;end;toc
Elapsed time is 0.396645 seconds.

This is an improvement over:
>> a=[];tic,for i=1:10000 a=[a RequestH];end;toc
Elapsed time is 2.313368 seconds.


and defamation case. I would also note there’s a comment section below the article which affords her or any other reader the opportunity to update or correct or clarify information in the story. Her failure to take advantage of that opportunity would also mitigate against defamation claim. Much of this is made clear in the course I developed referenced above.

Sincerely

Robert Cox

Publisher and Managing Editor

Talk of the Sound”

We got another email and letter tonight. Here they are along with my replies.

As you know, my firm represents Ms. Chrissy Stanionis in response to your false statements, provided to you from your anonymous “knowledgeable sources”, as published in your January 26, 2018 article, Ms. Stanionis demands the removal of the false statements in your article and states the following material factsand other equitable relief in Westchester County Supreme Court and to assert causes of action against you and your publication for libel per se. Further, my client’s damages are presumed because your published defamation is libel per se regarding my client’s professional reputation as a cheerleading coach. Please take the proper actions to avoid unnecessary litigation, correct your serious factual errors and address the issues raised above otherwise your actions will be considered to be malicious. Be advised that any further attempts by you to defame my client will be taken very seriously. Please be guided accordingly.”

My reply…

As is always the case, I am always quite happy to review and correct any article I write. It is unfortunate for you and your client that neither of you thought


my correction on this point:

Chrissy Stanionis was not “separated from employment by the District in May 2017” as she originally told Talk of the Sound. She was fired by Steve Young on April 21, 2017.”

Hope that helps!

“Ms. Stanionis had no part in the so called “significant financial irregularities with the Program.” Your statements here are contradictory because you previously quote Ms. Stanionis in your May 2,2017 article stating: “Stanionis said she was unaware of any financial issues. She added the her program is funded by a seperate 501(c)(3).””

My statements are not contradictory here because I have yet to state Stanionis had a part in “significant financial irregularities with the Program. This would explain your note quoting such a statement as I never made such a statement. As IMy match got me these TIGHT metal bookmarks and they are so so nice. I am beyond pleased with this gift, like I was so happy about them my roommate, who was doing hw near me, was like "God calm down, you're such a loser." WHATEVER BYE HATER these bookmarks are the tits.


where lots of people aren’t bothered by the lack of channel 1. And they do so even if the proposed fixes will mean some people’s televisions won’t work any more.

“Sure, but they’ll be better televisions!” Maybe, but it misses that a consistent channel numbering system is not what most people want out of a television.balance hasn’t quelled the situation.“The violence in Afrin disrupts what was a relatively stable area of Syria,” Mattis lamented in Indonesia. “It distracts from the international efforts to ensure the defeat of ISIS.”
For the Kurds, an ethnic minority in multiple countries of the region who’ve been abandoned by more powerful allies before, the result could be worse than distraction. The U.N. says an estimated 5,000 people have been displaced by fighting in northern Syria, and it’s unclear what the U.S. is willing to do to calm the situation.
Asked if Washington had a moral obligation to the Kurds, senior U.S. officials who briefed reporters on condition of anonymity said Trump’s “America first” doctrine dictated that the U.S. always prioritize its own interests.
____
Lee reported from Paris. AP National Security Writer


in two patients. Four patients had dysphagia, one each had dilated cardiomyopathy and respiratory failure. Electromyograph was abnormal in 15 patients and antinuclear antibodies were positive in nine patients. Prednisolone and methotrexate were used in 17 patients. Other disease-modifying anti-rheumatic drugs used were hydroxychloroquine, azathioprine, cyclophosphamide and cyclosporine. Sixteen patients achieved remission. Five patients had pyogenic infections and one patient died of this. In addition two patients had tuberculosis. Compared to our experience in the previous decade we saw more girls, used methotrexate upfront but the median duration of illness and prevalence of calcinosis (30%) was the same, suggesting that we need to improve awareness about JDM among paediatricians for early referral.of "formula grants for projects that reduce total energy use and fossil fuel emissions," according to a separate White House statement.

"Local leaders will have the flexibility in how they put these (energy efficiency) resources to work, but we will hold them accountable for making the investments quickly and wisely to spur the local economy and cut energy use," Biden said.

Don't Miss

Biden, who made the announcement at a meeting with several Cabinet and other senior White House officials, is the administration's point man in overseeing the distribution of the $787 billion stimulus plan.

He is being assisted by former Interior Department Inspector General Earl Devaney, who has been tapped to head a new Recovery Act Transparency and Accountability Board.


    ]
In this example, the correction angle is the maximum correctable angle or below, and thus, the correction is possible.
In contrast, when photographing in which the exposure time is ⅛ seconds is performed, the correction angle finally needed is below.
                              6          ×                      1           British Columbia and Vancouver's Island are merged into a single colony. English remains the only official language.
  1871:  The Crown Colony of British Columbia becomes a Canadian province. English remains the only official language in matters of provincial jurisdiction.

Manitoba
  1845: The Council of Assiniboia agrees to promulgate all laws in both French and English. Given the small size of the colony and the limited literacy of the population, promulgation consists of distributing bilingual copies of all ordinances be put on public display at the courthouse, distributed to all Protestant and Catholic clergy, “and, lastly, that copies, in both languages, be read aloud and explained at meetings of the General Court in November and February of each year....”
  1849: The Council of Assiniboia