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Mar262011An Integral Part of Your Overall Business Plan A comprehensive emergency management program is a necessary part of any business, and Nasburg Huggins Insurance wants all businesses in Oregon to be prepared.... more ›

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Any help will be really appreciated

A:

dest was null because the method of getByUid wants unique data-uid which created dynamically by kendo grid.
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Make sure dest.parent should reach to the tr element where further dest.parent().data("uid") will read UID from tr
Hope this will


Introduction
============

Chemokine receptors form a large family of G-protein coupled receptors that mediate chemotaxis of cells towards a gradient of chemokines. The chemokine receptor subtype CXCR4 exerts its biological effect by binding its ligand CXCL12 (stromal cell-derived factor-1, SDF-1) which activates downstream pathways such as the MAP kinase and the PI3 kinase pathway, ultimately resulting in altered expression of adhesion molecules and cell homing. Physiologically, the CXCR4/CXCL12 interaction plays a pivotal role in a variety of processes that rely on the recruitment and homing of stem and progenitor cells or of immune cells, i.e. in embryogenesis, neoangiogenesis, hematopoiesis and in inflammation [@B1]-[@B3]. CXCR4 is normally expressed on T-lymphocytes, B-lymphocytes, monocytes, macrophages, neutrophils and eosinophils as well as hematopoietic stem and progenitor cells (HSPC) in the bone marrow [@B4]. Antagonizingnational regulations. Informed written consent was obtained from the patients prior to the investigation.

PET/CT acquisition was performed according to standard clinical protocols on a Siemens mCT PET/CT scanner (Siemens Medical Solutions, Erlangen, Germany). For \[^18^F\]FDG PET/CT, the patients fasted for 6 hours before scanning, and blood glucose levels were measured just before injection to ensure a value below 150 mg/dL. The patients were injected with 300-500 MBq of \[^18^F\]FDG and the acquisitions were started after 90 min p.i.. Acquisition time was 2 min per bed position (BP). For \[^68^Ga\]pentixafor PET/CT, the patients were injected with 200 MBq \[^68^Ga\]pentixafor, and the acquisition was started 50 min p.i.. Acquisition time was 3 minutes per bed position.

For attenuation correction in both scans, a low-dose CT (120 keV, 20 mAs) in shallow


of \[^68^Ga\]pentixafor, such as urinary bladder wall (15.06 mGy/185MBq), spleen (9.95 mGy/185MBq), or kidneys (6.48 mGy/185MBq), and the total effective dose are notably lower (total effective dose for \[^68^Ga\]Pentixafor, \[ ^68^Ga\]DOTATOC and \[^68^Ga\]DOTATOC: 2.89 mSv, 3.89 mSv and 3.89 mSv, respectively) (Table [1](#T1){ref-type="table"}). Thus, based on the excellent pharmacokinetic profile and fast clearance kinetics, \[^68^Ga\]Pentixafor exhibits a favorable dosimetry. A detailed analysis of the biodistribution and radiation dosimetry of \[^68^Ga\]Pentixafor in humans is given elsewhere^67^.

Discussion
==========

Activation of the CXCR4/CXCL12 axis is a frequent event in a wide spectrum of pathologies, ranging from vascular diseases such as chronic heart failure, cardiac regeneration after acute myocardial infarction [@B35] and recovery after cerebral stroke [@B76] over autoimmune diseases [@B77] to tumorigenesis, cancer cell proliferation and metastasis [@B78]. These processes are often accompaniedby the Deutsche Forschungsgemeinschaft (SFB824; subprojects Z1/4, A5/7/8, B5/8 and C3. U.K. is further supported by DFG grants KE 222/7-1 and DJCLS R11/18. H.K. thanks for financial support by the Center of Integrated Protein Science Munic (CIPSM) and by the King Abdulaziz University KAU (grant No. HiCi/25-3-1432).

SDF-1

:   Stromal-cell derived factor-1

HSPC

:   hematopoietic stem/progenitor cells

NSCLC

:   non-small cell lung cancer

AML

:   acute myeloid leukemia

PET

:   positron emission tomography

DOTA

:   1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid

\[^18^F\]FLT

:   \[^18^F\]Fluorothymidine

\[^18^F\]FDG

:   \[^18^F\]Fluorodeoxyglucose

HA-tag

:   haemagglutinin-tag

EDTA

:   ethylendiaminetetraacetic acid

CHO cells

:   chinese hamster ovary cells

DAB

:   diaminobenzidine

SUV

:   standardized uptake value.

![CXCR4-expression on transfected CHO cells. (A) CXCR4-expression profile on wt-CHO cells, Jurkat cells and CHO cells transfected with HA-tagged human CXCR4, murine CXCR4 and


at the level of the kidneys. E) \[^68^Ga\]Pentixafor PET/MR in a patient with multiple myeloma (PET MIP) with F) transaxial image at the level of the maxilla demonstrated no uptake in the maxilla (green arrow). G) Corresponding \[^18^F\]FDG PET/MR (PET MIP) of the patient depicted in E) and F) with corresponding H) \[^18^F\]FDG PET/MR transaxial image at the level of the maxilla (red arrow, same region as depicted in F) showed \[^18^F\]FDG uptake in the maxilla/ floor of the maxillary sinus, most likely caused by a dental infection.](thnov05p0618g006){#F6}

![CXCR4 expression in tumor bisopsies. Previously obtained representative biopsies (A, B: from DLBCL patient shown in Fig. [6](#F6){ref-type="fig"}A; C, D: from CLL patient with suspected transformation into DLBCL shown in Fig. [6](#F6){ref-type="fig"}C; E,F: from MM patient shown in Fig. [6](#F6){ref-type="fig"}E) wereSaturday but other than that glorious weather. The sun and the people in Hull throughly enjoyed the day

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is made from summer tourism on the water here." "Good job!" "Who's next?" "Who's next?" " Me!" "Me!" "Me!" " I wanna get dunked." "♪ Who's been playin' around with you?" "♪" "♪ A real cool cat with eyes of blue... ♪" "Oh, God." "This is my first interview ever with Mayor Stockman." "I think I made him do this interview like four different times." "I think I even told him his hair dried fast because he's bald." "Yep, it does dry fast, yeah." "So, I think we can show just about everybody that comes on down a really good time." "Yeah." "Cool." "Of course, at the time," "I had no idea how culpable he was for what was about to happen." "The first signs that something washave?" "Uh, mercury levels way above standards, polycyclic acids, OPs," "PCBs that haven't been legal in 20 years." "Endocrine disruptors, pharmaceuticals," "Viagra, estrogen, DDT," " trace amounts of GRDF." " Phew." "I mean, pretty much you name it, it's in there." "I mean, looky here." "Naw." "This whole stream of toxin is following the current." "The what's following the what?" " You have a very thick accent sometimes." " Sam." "This whole stream of toxin is following the current." " Yes." " Look." "It's going next to this little town." "Claridge." "Claridge." "There were people who were concerned about what was going on in the bay." "With some of the townsfolk, it did cause arguments." "Your chicken plants are putting chicken shit in my bay and they're killing."


" That's the plan." "We'll just... do that." "Okay, we have some more dead fish here." " All mutilated." " What?" " All mutilated." " Oh, mutilated." "We have... here, we have..." "the tongue is missing on these." " No tongue?" " And on these others, the flesh looks almost like it's been bitten." " It's very confusing." " Why is that?" "I'm not sure what does this." "Um, fish don't bite fish." "There she is." "I'm so tired of posing." " Come on, let me film you." " No, no, no, no, no." " Yeah, yeah, yeah." " Oh, God." "I don't wanna end up on the Internet." "Come on." "It's not like I'm gonna put you naked on my Facebook page and see what the commentsany response from my guys." "Well, we shut down all the towers to kill the cell phones, but it shouldn't affect you guys." "Listen, Lee." "Why don't you swing by and pick me up right now?" "I wanna get a firsthand look at what's going on out there." "All right, I'll be by there in about five minutes." "You okay?" "I don't think I've ever been so scared in my whole life." "Is the blood off my face?" " What?" " Is the blood off my face?" "No, you've got a ton on your side." "What the..." " What?" " What is that?" "What is it?" "Holy shit." " Fuck." " What the fuck?" " Oh." " Oh, my God." "Look at his face." " Oh, my God."


dark-shaded, and bricked. The light-shaded region is $C_i$; it sits in $F_{top}$ (the triangle with dashed outline). The set $D_i$ extends $C_i$ and includes both the light-shaded and dark-shaded regions of $A_i$. The bricked region is $E_i$; it sits in the facet antipodal to $F_{top}$. Note its relation with $C_i$. []{data-label="lsbsets"}](lsbsets){height="3in"}

Now let $A_i=D_i \cup E_i$. We shall verify that the $A_i$’s cover $\Sigma^d$ and are closed sets, yet no $A_i$ contains a pair of antipodes. This verification will contradict the LSB theorem, forcing us to reject our initial assumption that the KKM cover had no common intersection point.

[**Part (II). Verification.**]{} Clearly the $A_i$’s cover $\Sigma^d$, by Observation \[Dicover\] and the fact that the $E_i$’s cover $F_{bot}$.

To show $A_i$ is closed, note that $E_i$ is a closed subset ofand Palestinian majorities still accept the two-state principle, If only as the least bad option. Even Benjamin Netanyahu, who came out for two states in a much-quoted speech in 2009, declared that he was still for it after declaring against it on the eve of the March 2015 election.

Nearly a century after the passing of the Ottoman empire, its legacy and loss can still be seen and felt from the Mediterranean to the Khyber Pass. Since World War II, the region has done its bit to finish off the British and Soviet empires; turned the United States into history’s most reluctant Middle Eastern power, and upended at least two American presidencies.

Since 2001, alienated young Muslims have weaponized airliners, kidnapped Nigerian schoolgirls, devastated shrines from Timbuktu to the Hindu


over the succession. For 200 years, West European crusaders, hellbent on hostile takeover of Christianity’s birthplace, inflicted mass mayhem on Jews and Muslims. From 1517 to 1648, European Christians turned their fratricidal attentions to one another while Ottoman armies advanced on Vienna. In the 1850s, Catholic French and Orthodox Russians insisted that each had a more legitimate claim to Jerusalem than the other. Their claims helped ignite the Crimean War.

In 1898, Germany’s Wilhelm II visited Jerusalem to dedicate the city’s second Protestant church. Before leaving, he received Theodor Herzl, who hoped the kaiser might lobby the Turkish sultan on behalf of infant Zionism. Instead, Wilhelm proclaimed himself protector of the Muslims en route home via Damascus. In the 1930s, for lack of secular alternatives, Palestinian Arabs looked toa cleric for leadership: Haj Amin al-Husseini, the deeply anti-Jewish, anti-British Grand Mufti of Jerusalem. Husseini, in turn, looked to Hitler’s Germany and spent the war years in Berlin.

Despite fond hopes, practical indifference or well-intentioned ignorance by the heirs of Sykes and Picot, Syria and Iraq are one more tutorial on what can happen in a political ecosystem where the secular nation-state remains the exception, and religious identity is a surrogate for national identity. In both countries, as well as Egypt, Christians are now an endangered species, while relations between Shi’a and Sunni, Iran and Saudi Arabia, increasingly recall early modern Europe’s Thirty Years War, with no Treaty of Westphalia in view at the end of the tunnel.

With 5 million people and 18 recognized religious communities, Lebanon alone


infrastructure devoted to this purpose, we first immunized WT (C57BL/6J) and B cell--deficient (J~H~T; [@bib21]) mice with CFA and performed immunostainings at the peak of the IgM response. As expected, IgM signal was absent from the LNs of B cell--deficient mice and colocalized with follicular B cells in control and reactive LNs of WT mice ([Fig. 1 A](#fig1){ref-type="fig"}). In reactive WT LNs, a second reticular pattern of IgM signal was observed in the T cell zone. As this area is supported by a 3D meshwork of reticular fibers known as the conduit system, we stained LN sections for collagen IV expression, an extracellular matrix molecule abundantly present in this infrastructure ([@bib46]). Data shown in [Fig. 1 A](#fig1){ref-type="fig"} indicate that IgM and collagen IV signals indeed colocalized. To determinein one ear. Ultrathin sections were stained with 6-nm gold nanobeads specific for mouse IgM (highlighted with arrowheads), and the average number of beads located in the conduit lumen was evaluated for each condition. Bars, 2 µm (upper panels); 200 nm (lower panels). Data are representative of two experiments (one individual per condition and experiment). Results are expressed as mean ± SEM. \*, P \< 0.05; \*\*\*\*, P \< 0.0001.](JEM_20180344_Fig1){#fig1}

Conduit-associated IgM originates from neither the lymph nor the blood {#s04}
----------------------------------------------------------------------

IgM found in the conduit system could have three origins. Tissue inflammation induces local vascular permeability and leakage of large plasma molecules ([@bib38]). Therefore, serum IgM might have been drained to the proximal LN via the lymph. Additionally, LN blood vessels such as HEVs and the primary feeding arteriole


coinjected, smaller fluorescent tracer, wheat germ agglutinin (WGA; 38 kD), was readily able to enter the conduit system ([Fig. 2 A](#fig2){ref-type="fig"}). SCS macrophages reside in the SCS and are known to transfer lymph-borne Ag and immune complexes to follicular B cells ([@bib9]; [@bib27]; [@bib39]). Because SCS macrophages are reduced in the absence of B cells ([@bib40]; [@bib35]), we reasoned that the inability of IgM to cross the SCS of J~H~T mice might result from the lack of SCS macrophages. To test this hypothesis, we took advantage of D~H~LMP2A mice ([@bib10]), in which the J~H~ segment of the IgH locus is replaced by the EBV-derived LMP2A protein that functions as a surrogate survival signal for B cells. Therefore, D~H~LMP2A mice retain B cells, SCS macrophages, and normal lymphoid tissuerobust extrafollicular proliferation of MD4 B cells ([@bib15]) and a concomitant HEL-specific IgM~a~ response as early as 4 d later ([Fig. 4](#fig4){ref-type="fig"}). Although IgM~a~ was detected on the surface of adoptively transferred MD4 cells in ndLNs and dLNs, an additional reticular signal appeared in dLNs when extrafollicular MD4 B cells were relocated to the T cell zone. Data shown in [Fig. 4 A](#fig4){ref-type="fig"} indicate that IgM~a~ colocalized with collagen IV^+^ conduits. We then performed similar experiments in *Ccl19*-Cre:Rosa^tdT^ mice harboring fluorescent FRCs and confirmed that soluble IgM~a~ was in the luminal side of conduits, supporting the ability of this system to channel locally secreted IgM also during an immune response ([Fig. 4 B](#fig4){ref-type="fig"}).

![**Locally produced, Ag-specific IgM localizes within the conduit system of reactive LNs. (A)** HEL-specific MD4 IgM~a~^+^


B cells and OVA-specific OT-II CD4^+^ T cells were adoptively transferred into WT mice. The next day, recipient mice were injected intradermally with an HEL-OVA chimeric protein emulsified in CFA, in one ear. 4 d later, auricular dLNs and contralateral ndLNs were harvested. Sections were stained for collagen IV (Col.IV), B220, and IgM~a~ and imaged by confocal microscopy. tdT, tdTomato. Bars, 200 µm (left panels); 10 µm (right panels). Data are representative of three experiments (two mice per experiment). **(B)** Confocal imaging of reactive and contralateral LNs from *Ccl19*-Cre:Rosa^tdT^ recipient mice treated as described in A. Bars, 5 µm. Data are representative of two experiments (two mice per experiment).](JEM_20180344_Fig4){#fig4}

In the second experimental model, we analyzed the ability of the conduit system to transport IgM upon viral infection. Vesicular([Fig. 5](#fig5){ref-type="fig"}, upper panels). In mice that were transferred with VI10YEN B cells, but not infected with VSV, IgM signal was exclusively detected on the surface of VSV-specific B cells ([Fig. 5](#fig5){ref-type="fig"}, lower panels). Upon VSV infection, VI10YEN B cells massively proliferated and relocated to the T/B interface at day 4, a time when they are known to secrete abundant levels of soluble IgM ([@bib36]; [@bib23]). Closer examination indicated that these IgM molecules were associated with the conduit system ([Fig. 5](#fig5){ref-type="fig"}, lower panels). This association was transient, as conduit-associated IgM disappeared from the dLNs at day 7, suggesting that the early protective wave of neutralizing IgM was already exported from the LNs at that time. Interestingly, 4 d after infection, IgM also associated with peripheral node addressin (PNAd)--expressing


with Imaris software (Bitplane). For unfixed LN slice preparation, fresh LNs were embedded in 4% low-melting-temperature agarose (type VII-A; Sigma-Aldrich), sectioned in 300-µm-thick slices using a vibratome (Leica VT1200) in a bath of ice-cold PBS, and immediately imaged by confocal microscopy.

EM {#s18}
--

LNs were fixed in AntigenFix for 2 h at 4°C and washed in 0.1 M phosphate buffer for 30 min. Samples were embedded in 4% agarose and sliced with a vibratome (Leica VT1200). 200-µm-thick sections were blocked for 30 min in 0.1 M UltraPure Tris Buffer containing 5% BSA and 5% goat serum (Jackson ImmunoResearch). Immunolabeling for mouse IgM was performed during 2 h. Sections were then washed in PBS and postfixed in PBS containing 2% PFA and 2.5% glutaraldehyde at 4°C overnight. The next day, samplesshows the silliness of that argument. I watch these people argue about trade deficits and how all our jobs are going overseas. Our jobs didn't go overseas; they went to robots. We're arguing horribly about, what is it, 30 to 50 thousand jobs being lost in coal mining and we can't absorb that? Well, within five years, and I am making these numbers up, of course, but 1.8 million truck drivers will lose their jobs [because] right now as we speak there is an 18-wheeler self-driving across the country. That job is going away in about five years, and I don't think the government can stop that. I don't think legislation can stop that. Luddites have never won, ever. They drag their feet, but they lose.

So I've already


negative consequences of abusive supervision. Indeed, despite emerging studies that address the regulation function of mindfulness at work (e.g., [@B23], [@B25]; [@B42]), [@B19] have called for further examination of the role of mindfulness in the workplace. Our research responds to this call and, in so doing, extends the literature. **Figure [1](#F1){ref-type="fig"}** depicts our theoretical model.

![The theoretical model. *Note*: E = employee-rated variables, L = leader-rated variable.](fpsyg-08-01588-g001){#F1}

Theoretical Groundings and Hypotheses Development
=================================================

In extant research, leader behaviors have been recognized as a critical contextual factor that impacts employee creative performance ([@B80]; [@B3]; [@B79]). For example, transformational leadership ([@B57]; [@B20]), benevolent leadership ([@B69]), and empowering leadership ([@B75]) have been identified as means to foster creative performance in the workplace. Most of this research has focused on positive leader behaviors, but some recentemployee self-efficacy at work on the relationship between abusive supervision and creative performance, such that the mediating effect is weaker for those high rather than low in mindfulness.

Materials and Methods {#s1}
=====================

Sample and Procedures
---------------------

We collected data from a company located in northern China. The participants were frontline technicians who worked in teams to manufacture various components of electrical equipment. In the company, employees were encouraged to be creative so as to solve work-related issues with novel and useful ideas. Our research plan had the full support of the company's top management team and also received assistance from the human resources department. To counter the potential threat of common method bias ([@B47], [@B48]), we collected data from two different sources (i.e., leaders and employees) across two time points (i.e., time


(*strongly disagree*) to 7 (*strongly agree*), was used (α = 0.93).

### Mindfulness

It was evaluated with the 15-item Mindful Attention and Awareness Scale developed by [@B11], which has been widely used to measure mindfulness traits in the general population ([@B23], [@B25]). Sample items included "I tend to walk quickly to get where I am going without paying attention to what I experience along the way" (reverse scored) and "I rush through activities without being really attentive to them" (reverse scored). A six-point Likert-type scale was adopted for this scale, ranging from 1 (*almost never disagree*) to 6 (*almost always*) (α = 0.89).

### Creative Performance

It was rated with a three-item scale developed by [@B44]. This scale asked the leader to evaluate his or her agreement on the following descriptions for(*B* = 0.04, *SE* = 0.06, *p* = 0.51, *n.s.*) while controlling for the effect of abusive supervision. Therefore, the obtained effects seem to be unique to creative performance ratings.

Discussion
==========

In this study, we explored explanations of *why* and *when* abusive supervision impairs employee creative performance. Adopting social cognitive theory as an overarching theoretical lens, we argued that employee self-efficacy at work is the mediating mechanism underlying the relationship between abusive supervision and employee creative performance. Furthermore, integrating social cognitive theory with a regulatory approach, we predicted that mindfulness is the boundary condition for the indirect effect of abusive supervision on employee creative performance via employee self-efficacy at work. Analyses of data collected at multiple time points and from multiple sources indicated that abusive supervision was negatively related to


make a servlet of basex see a database folder already available?
Update:
  Every time I run the servlet it seems to point to the data folder in the war, no matter what I put in the dbpath param in web.xml. I'm assuming /myfolder/BaseXData would be treated as an absolute path, but the war seems to default to it's data folder without giving me an error that it doesn't see were I'm telling it to go.
I can build my data into the war by replacing the data folder with a symbolic link, but that won't allow changes to persist, so it isn't a complete solution.
It also seems that the newest versions of Basex are supposed to resolve this by building the rest component it, but it doesn't seem tothis clock, was to be able to experiment with this board and scratch the surface at what it can do.

A few years ago I bought a VFD clock from Adafruit, but after a couple months the clock would be a few minutes slow. The reason for the drift comes from the crystal oscillator used to keep track of time, even with an accurate crystal, it wasn’t 100% accurate and the error would build each day, until it was a few minutes slow and needed to be reset. For my clock, I wanted to make sure that never happened, and that’s why I decided to use the ESP8266. The WiFi board will talk to a Network Time Protocol (NTP) server and retrieve the current time every day.

The Main Guts

The


for the first time”. Allen Hornblum’s Book is an agitating and moving response to the torturous experiments he initiated in Holmes burg Prison, Philadelphia during 1951 to 1974. These abuses “terminated with scandal surrounding the Tuskegee syphilis Experiments”.

The Book is a breakthrough storey narrated by a man named, Allen M. Hornbun, who initially engaged himself to conduct Adult Literacy Program for Holmesburg Prison Inmates in 1971 and for a prolonged period of two decades. In the course of it he developed close friendship with prisoners. During his stay as Literary instructor he keenly observed the deadly abuses inflicted on Prison Inmates The horrors of the stories these Prisoners told him pierced through his mind, heart and whole of his being. After resigning from Philadelphia Sherif’s office in 1994which ambition and profit became the ultimate good and the pursuit of scientific knowledge took precedence over the rights of individual human beings.

Hornblum being closely associated with the prison and prisoners has firmly established his Target after through research findings – the prominent manufacturing Giants – particularly those in Dermatology, who were greedy to find out ‘low cost’ Research Facility as extention of Manufacturing Arm. The most dramatic and well-known chapter in the history of research with human participants opened on December 9, 1946, when an American military tribunal opened criminal proceedings against 23 leading German physicians and administrators for their willing participation in war crimes and crimes against humanity. Among the charges were that German Physicians conducted medical experiments on thousands of concentration camp prisoners without their


Ivy Research laboratories, the prison system and the city for $ 400,000 for violation of his civil rights.

Subversion of Philosophy of Science and turn to Barbaric Sadism

Miamonides, a 12th century philosopher, who followed the footsteps of Aristotle, as Physician had advised his colleagues to treat patients not merely as means to the acquisition of knowledge, but as valuable in themselves. 800 years later, another physician, Dr. Kligman advised his colleagues and taught his students that ‘rules don’t apply to geniuses. An uninformed and desperate group of prisoners met an unrestrained and ambitious doctor and largest, nontherapeutic, human research factories. Even more remarkable is how such a large and intricate operation in a public facility went so long unnoticed and unchallenged. Several reasons for this lapse in social and1998 articulates pains of those who have suffered for our Benefits and exposes the ruthless face of modern capitalism!

Acres of Skin—Human Experiments at

Holmesburg Prison: A True Story of Abuse and Exploitation in the Name of Medical Science

by Allen M. Hornblum

New York: Routledge, 1998

297 pages, paperbound, $16

Anil Pundlik Gokhale is an Engineer by profession and have been a reader and student of Marxist and Freudian literature for last four decades.He has been a professional translator of medical and other literature from English to Marathi. As a non regular writer on political literature he has always been attempting to intigrate Psychology and Marxism.He has recently published books ‘Condensation And Condescension In Dreams And History: Essay – From Sigmund Freud To E P Thompson’ by Author House London. Psychoanalysis & A-


defense was a bare denial of wrongdoing without an accompanying theory of how he would rebut the Division's complaint.  The CFTC's determination is sound.  Catalfo did not proffer enough detail for the CFTC to validate his claim of excusable neglect, and his proffered defense was unsupported and lacked sufficient particularity.

10
In Nelson, we held that "a client must exercise reasonable diligence in checking with his counsel and monitoring" his case.  962 F.2d at 756.   A client's failure to keep himself apprised of the progress of his litigation because of ignorance or carelessness is without relief after a default judgment has been entered against him as a result of his counsel's actions.  Id. In Pretzel & Stouffer v. imperial Adjusters, Inc., 28 F.3d 42,on it pending motion by letter, which was not personally served upon Catalfo, and that the entry of default against him without his receiving personal notice violates his right to due process.  His claim is without merit.  Catalfo's lawyer was personally served with the letter requesting the immediate decision.  There is no controlling rule or statute requiring such a request to be a formal pleading, to be verified by affidavit, or to be served upon the defendant directly.

15
Notice generally satisfies due process if it is "reasonably calculated, under all the circumstances, to apprise interested parties of the pendency of the action and afford them an opportunity to present their objections...."  Mullane v. Central Hanover Bank & Trust Co., 339 U.S. 306, 314 (1950).


[@CR8]\]. For this, clinical coders need to have access to all the data contained in the medical record.

With the increasing use of electronic health records (EHR), such data become more easily available, especially through clinical data warehouses (CDW) that are great sources of integrated heterogeneous and exhaustive information \[[@CR9], [@CR10]\]. In parallel, knowledge databases, such as pharmaceutical databases, are used to analyze and process clinical data and can also support clinical decision-making \[[@CR11], [@CR12]\]. The challenge lies in combining these different sources of information to improve the accuracy and exhaustivity of medical codes.

The aim of this study was to develop an algorithm to detect comorbidities in EHR using a clinical data warehouse and knowledge databases. We focused on two different types of data, drug prescriptions and laboratory tests,suggested a list of ICD-10 codes, among which some were included in the Comorbidity List and were thus flagged as possible comorbidities.

### Step three: Detection of comorbidities in the EHR using drug prescriptions and laboratory test results {#Sec10}

In the last step, we improved comorbidity detection by using another source of structured data. For this study, we focused on sodium polystyrene sulfonate (SPS), because this drug is only prescribed in the case of hyperkalemia (ICD-10 code E87.5). As the French Nephrology Society defines hyperkalemia as a plasma potassium level higher than 5.0 mmol/L \[[@CR18]\], we compared drug prescriptions and laboratory test results to detect hyperkalemia in all EHR.

Study populations {#Sec11}
-----------------

We retrospectively tested the algorithm using two different datasets extracted from the EHOP CDW. The first dataset included all stays of


the 122 stays of the ENT dataset, 339 (46.4%) were detected by the algorithm. The algorithm suggested a possible missing comorbidity in 92 of the 122 stays (75.4%) (Additional file [3](#MOESM3){ref-type="media"}).

The expert confirmed the suggested diagnoses in 41 of these 92 stays (44.6%) and added 58 ICD-10 codes to the stay (Additional file [4](#MOESM4){ref-type="media"}). Among these 41 stays, 12 (29.2%) had a major comorbidity (i.e., included in the French Comorbidity List) (Table [1](#Tab1){ref-type="table"}) (Additional file [5](#MOESM5){ref-type="media"}). Recall was 95.3% and Precision was 44.6%, with an F-Score of 60.7%.Table 1Number of stays in which comorbidities (ICD-10 codes) were detected by the algorithm using the drug prescriptionsENT datasetGeneral datasetStays\
(*n* = 122)ICD-10\
codes\
(*n* = 730)Stays\
(*n* = 4312)ICD-10\
codes\
(*n* = 4932)Comorbidities detected using the drug prescriptions; number (%)30 (24.5)339 (46.4)1362 (31.6)1271 (25.8)Missing comorbidities; number (%)92 (75.4)--2950 (68.4)--Suggested comorbidities*n* = 92n = 285^b^ Suggested comorbidities, confirmed; number (%)41 (44.6)58 (+7.9 ^a^)58 (20.3)76 (+6.0in case of disagreement between the experts. (DOCX 19 kb) Additional file 3:Characteristics of all ICD-10 codes suggested by the Theriaque database. This table describes the aggregated characteristics of all ICD-10 codes suggested by the algorithm for each dataset. The codes are separated between "Match" codes (codes added after expert review) and "Non-match" codes (codes that could not been added after expert review). (DOCX 15 kb) Additional file 4:Characteristics of the ICD-10 codes added after expert review. This table describes the aggregated characteristics of the ICD-10 codes added to each dataset after the manual review by the two experts. It also count the number of ICD-10 codes that were part of the CMA list. (DOCX 13 kb) Additional file 5:List of the ICD-10 codes added after expert review. This table lists


to authorized users.

Not applicable.

Funding {#FPar3}
=======

This work was supported by a grant from the Brittany Region, through the ID2Santé program (QUALIMED).

Availability of data and materials {#FPar4}
==================================

The data that support the findings of this study are available from Rennes University Hospital but restrictions apply to the availability of these data, which were used under license for the current study, and so are not publicly available. Data are however available from the authors upon reasonable request and with permission of Rennes University Hospital.

ES, GB, EC, MC and CR defined the study methodology. ES and GB built the algorithm. ES, and CHM reviewed every patient from the datasets. GB reviewed the cases where ES and CHM could not reach a consensus. ES wrote the manuscript and MC, EC and GB carefully reviewedon screen: Japan Expo Video: The Family

09:10

Daniel: And then there was the expectation that they would lead these people to Jesus or pray with them to receive Jesus as their savior.

Unidentified female #5: Here we see Faithy as she witnesses to the vice president of an oil company from Sweden and he's asking her at this time, "Do you think I'll go to Heaven?" Very sweet, very sweet man who enjoyed their contact that night.

Judy: I was never asked to share until the FFing thing came out and thenn it was kind of a pressurized thing, it was like either do it or you're out.

Interviewer: What was it like to have to do that?

Judy: What was it like?

Interviewer: Yeah.

Judy: I don't want to go there.

10:00

Daniel: David Berg in


I don't know. I'm starting to think that life goes on and that fucking scares me, that really does scare me more than anything because I don't know, I don't want it to go on, I just want it to be over.

12:10

Sarah: He talked about suicide a lot. And I would ask him, why he felt like that, why did he want to die and he said "because I'm already dead."

12:36

Rick: Ok, we're back. So anyway, duct tape. You can fix anything with this fucking stuff. Yeah, I'm going to fix some people with this. Anyway, ok, I'm sorry I'm getting all off track here. Where the fuck was I? Suicide, yes, suicide.

13:05

Narrator: Twenty-four hours after Rick recorded his video, he left his Tucson apartment and hit thethat included sexual encounters she had had with him and how she used to masturbate him to sleep and how she would make sure that he would have his love up time before bedtime. It was just so... it was really... I don't know, you have to read the book. It's really... So that's what the Davidito book was, just a book written about our lives and how we were raised and how other people should imitate the way we were raised to try to do the best to raise their children accordingly.

19:26

Narrator: By the early 80s, David Berg was on the run from Interpol on suspicion of pimping. Moving with Rick and Davida from one secret compound to the next he never met ordinary members. Now, he


what I haven't come to understand yet is how such a large group of people, of diverse backgrounds, of diverse ethnicities, of income levels, can so readily turn to wholesale pedophilia. Not everybody engaged in it but if you were in The Family you knew about it.

Narrator: The Family deny that Karen Zerby ever had sex with Rick and say that he himself never made this allegation. Nevertheless, whatever happened in David Berg's bedroom had a profound effect on Rick and his sister. In recent years, Davida has struggled with drug abuse and today earns her living as an exotic dancer.

Rick: Jesus Christ, you know, anger does not begin to describe how I feel about these people and what they've done. I mean rage.

Don: We want to releasewere caught in the middle of this in a sense.

Rosemary Kanspedos: No, I wasn't caught in the middle. He was my nephew. He needed help. He was the one that was going to be helped and any anger he had, he had a right to it. His mother didn't take care of him. He didn't have a mother.

Tom Kanspedos: Growing up in... where he was and not doing drugs, getting out, I thought, You're amazing that you've gotten out and this is the first step and you're struggling right now, it's very difficult but take another step, keep taking one step at a time...

Rosemary: He sat one time and just said "I don't know. I don't know if I can go on." And this was probably a week


or so before. And I had known that it was coming. It wasn't a question of... a matter of "maybe it'll come" it was a matter of when it was going to happen.

41:50

Narrator: Rick rented a room in a rough part of town and found a job as an electrician. He practised martial arts at a local gym and joined a gun club. And he waited for his mother. Four months after arriving in Tucson, Rick set up his new video camera and pressed record.

Rick: There's this need that I have. This need. It's not a want, it's a fucking need and I wish it wasn't but it is. It's a need for revenge, it's a need for justice. Because I can't go on like this.

Text on screen:his mother. It was her close confidante, Angela Smith. Smith had helped raise Rick and features in the Story of Davidito under the pseudonym Sue. He arranged to meet her early in the evening of January 8th, planning to force her to reveal his mother's whereabouts.

Rick: I'm not trained in torture methods which is why I'm going to have to make do. I've got my drill here. The reason why it's got this fucking padding on it is just to try to silence it a bit because I'm in an apartment. I've got a soldering iron, heat. This rather crude implement I think can work wonders especially if it's used in the right way. But I'm not trained. I don't know how to fucking do this. I don't


but they’ve also highly enjoyed the experience of getting to know me and learn the lessons behind how I’ve made things. Someone even compared my feature update newsletter to waking up on Christmas.

It’s a necessity. Draft is the product of just one person. I’ve got a ton of competition from giant companies and well-funded startups. I can’t compete with Google Docs by trying to imitate Google. But I felt like if I could open myself up, and connect with an audience on a human level, maybe I had a chance to get people’s attention. It worked.

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I learned a lot from 37signals. Even in 2007-2008, you’d see Jason Fried’s name at the bottom of their newsletters. I “grew up” as an entrepreneur watching 37signals and reading their book GettingMarathon Alberta oilsands holdings for $12.74B

“This transaction creates value for our shareholders by achieving a clean and timely exit from Canada, while accelerating efforts to focus exclusively on our high-return U.S. oil portfolio,” Devon chief executive Dave Hager said in a statement on Wednesday.

Wednesday’s deal is Canadian Natural’s seventh major acquisition since 2014, when it struck a $3.12-billion agreement to buy most of Devon’s non-heavy oil Canadian assets, according to a report from Wood Mackenzie.

“This continues the trend of Canadian-domiciled consolidation that we’ve seen since 2016,” said analyst Stephen Kallir. Tweet This

“In 2020, the oilsands will produce 3.3 billion bpd and just four companies now account for 85 per cent of that volume.”

Wood Mackenzie points out Canadian Natural stands to be the largest producer in Canada with 1.2


- n + 5*n - 3*n - q wrt n?
1
Let p(o) = -o**6 + 4*o**3 + 9*o**2 - 4*o. Let h(r) = -r**6 + 5*r**3 + 9*r**2 - 5*r. Let s(k) = -4*h(k) + 5*p(k). What is the third derivative of s(c) wrt c?
-120*c**3
Let k(p) be the first derivative of -p**6/20 - p**5/60 + p**2/2 - 2. Let z(c) be the second derivative of k(c). What is the third derivative of z(n) wrt n?
-36
Let w = 0 - -4. Find the second derivative of -w*q + 3*q**3 + 5*q + q wrt q.
18*q
Let p(m) be the second derivative of -m**6/10 + 7*m**3/6 + 11*m. What is the second derivative of p(q) wrt q?
-36*q**2
Suppose -3*f + 25 = -4*l, 2*f + 5*l + 10 = l. Let m =Watch Radiohead Perform A Moon Shaped Pool Songs Live for the First Time, Plus Some Oldies

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Radiohead is perhaps the best live band on the planet, because their live performances are constantly evolving. They don’t grow stagnant, like so many other ’90s rock bands. Instead of just harping on their 20-year-old guitar-rock songs to appease “I miss their old stuff” fans, they put on a show of serene beauty at Amsterdam at the Heineken Music Hall this week, performing seven songs off A Moon Shaped Pool for the first time. (They also exhumed a few Bends-era tracks, for those missing the halcyon days.) They opened the 24-song show, their first in almost four years, with “Burn the Witch,” “Daydreaming,” “Decks Dark,” “Desert Island Disk,” and “Ful Stop,” the first


a motion to dismiss, "[t]he question is whether in the light most favorable to the Plaintiff, and with every doubt resolved in his behalf, the Complaint states any valid claim for relief." 5A Charles A. Wright & Arthur R. Miller, Civil 2d § 1357, at 336. The Court must consider well-pled allegations in a complaint as true and must construe those allegations in favor of the plaintiff. Scheuer v. Rhodes, 416 U.S. 232, 236, 94 S.Ct. 1683, 40 L.Ed.2d 90 (1974); Jenkins v. McKeithen, 395 U.S. 411, 421-22, 89 S.Ct. 1843, 23 L.Ed.2d 404 (1969). The Court must further disregard the contrary allegations of the opposing party. A.S. Abell Co. v. Chell, 412 F.2d 712, 715 (4th Cir.1969).

III. DISCUSSION

Defendant presents several arguments[8] in support of its Motion topresent their FTCA claims in a timely manner should not now operate to afford them a second day in court.
Plaintiffs have failed to articulate any sufficient justifications for their failure to file the FTCA claims in the prior litigation. The records show that Plaintiffs presented their FTCA claims to NCUA on January 31, 1997, after the Lafayette I complaint had been filed,[11] and amended the FTCA claims on February 13, 1997. Under FTCA's exhaustion requirements, no court would have jurisdiction to hear Plaintiffs' FTCA claims until either NCUA disallowed the administrative claims or six months had passed from the filing of the administrative claims. 28 U.S.C. § 2675(a). Plaintiffs allege that because NCUA did not act upon Plaintiffs' FTCA claims, no federal court would have jurisdiction over their


pressure on. When I do the forearm version, it doesn't hurt.

I do two sessions of LHT a week with my planks included, and it's definitely giving me some tone - now just have to get the flab off of the top of the toned muscle so I can see it more.church and my money.”

From Stephen Thomas at Rational Apologetics: Prayer to God Doesn’t Work. On… well, on why prayer to God doesn’t work. With many well-marshalled arguments, and a nifty video about worshiping milk jugs.

From vjack at Atheist Revolution: America’s Evolution Denial. More Americans believe in the devil than Darwin. Why is this important, what causes it, and what can we in the reality-based community do about it?

From Kelly OâConnor at The Atheist Response: Humans Do Not Need to Comfort Themselves With Fairy Tales. A response to the argument that people need religion… regardless of whether it’s true. “Atheism is not the destruction of the quest for meaning — it is the necessary starting point for the journey.”

From A.C. Chase at Alexander the Atheist: Why Mike Huckabee Hates


the electrical features of the second generic layer to produce a second personalized layer different than the first personalized layer. The altering changes the generic layer into a plurality of differently personalized layers. The generic layer includes a grid of vias and/or a pattern of wiring useful with a plurality of differently personalized layers.
Another embodiment of the invention is a process for personalizing a multi-layer substrate structure that includes supplying a layer having generic electrical features and altering the generic electrical features to produce a personalized layer of the multi-layer substrate. The altering includes selectively filling vias in the layer with conductive material and removing portions of electrical wiring on the layer. The process further includes supplying a second layer identical to the first layer and altering thegeneric electrical features of the second layer to produce a second personalized layer different than the first personalized layer. The altering changes the generic layer into a plurality of differently personalized layers. The layer includes a generic grid of vias and/or a generic pattern of wiring useful with a plurality of differently personalized layers.
Yet another embodiment of the invention is a multi-layer substrate structure that includes at least one layer having generic electrical features altered to personalize the layer. The electrical features include vias selectively filled with conductive material and/or a wiring pattern having portions selectively removed. The multi-layer substrate further includes a second layer similar to the first layer and having the generic electrical features altered differently than the first layer to personalize the second layer differently


should i not use a timer, but instead call "parseRssFeed" every time the parser finishes and returns data to the delegate? What is best programming practice?
Please let me know if i have provided enough information.
Thank you!

A:

This depends how often you want to use the parser. If you only parse data once a minute there is no need to store a parser in an object.
If you parse the data 10 times a second you have to allocate once and store the parser.
As the other poster (who deleted his answer because this is not a .net question) suggested I made a little performance test to show that an alloc is a really slow operation.
for (NSTimeInterval i = 0; i < 1000; i++) {
    self.label1.text = [dateFormatter stringFromDate:[NSDatedateWithTimeIntervalSinceNow:i]];
}

vs
for (NSTimeInterval i = 0; i < 1000; i++) {
    NSDateFormatter *localDateFormatter = [[NSDateFormatter alloc] init];
    self.label2.text = [localDateFormatter stringFromDate:[NSDate dateWithTimeIntervalSinceNow:i]];
    [localDateFormatter release];
}

gave a result of 0.0017 seconds for the first version, and 0.28 seconds for the second version. You'll get the idea. Yes, NSDateFormatter might be one of the more complex examples of an object.
If you want to use an object like a parser or a dateformatter often I would store it somewhere.


Part of the superiority of a Paperwallet is in its ‘micro wallet’ sizing. How is it possible that such a small wallet can still fit a full set of cash and cards? The answer lies in the art of paper origami. Origami-inspired the design of every Paperwallet and contributes to the blend of art, science, and style that makes the Paperwallet so unique.

What is Origami?

The Japanese word ‘origami’ originates from two other words, ‘oru’ which means ‘to fold’ and ‘kami’ which means ‘paper’. The art requires very few materials, a square sheet of paper (often with a colored side, but not required) and a set of hands. Sculptures resembling animals, symbols, and even people are created by repeatedly folding a singular piece of paper. Origami pieces can rangeof origami in European countries. Paper folding was first introduced to Spain by the Moors in the twelfth century. This practice then expanded and by the 1800s, paper origami folding was a common activity taught to both Japanese and European children from a young age.

Origami Today

Paper origami has developed in increasingly complex ways throughout time. Artists have branched off to incorporate mixed materials and new combinations of old designs to bring the traditional art into the modern day. Due to the larger and more intricate nature of modern origami pieces, many disregard the rules surrounding the use of scissors or only a singular piece of paper.

Today, origami artists have built upon the traditional artform to modernize origami for use in the world today. Origami artists now incorporate math,


lightweight accessory that still had enough room to fit a users’ valuable items. Paper origami provided the inspiration needed to achieve a sleek and minimalistic look while simultaneously optimizing space for a compactly designed wallet. The perfect material was found in Tyvek®, which boasts superior lightweight and durable qualities. Though it is not actually paper, Tyvek® looks and feels like it, which allows it to be folded in the origami style when creating wallets.

Specifically, the slim wallet, card wallet, and micro wallets are nearest to the traditional origami craft. They are made from a single piece of Tyvek® that has been folded into the wallet. The clutch wallet, coin pouch, and flat wallet are made from several Tyvek® pieces that have been sewn together. However, they are stillor the idea that the Excitable Boy needs to put something in a cage.

The genius of Excitable Boy lies within Zevon’s masterful hand over macabre humor. Everything that happens in the song is immensely distressing, but as the people around the Excitable Boy explain – he’s just that excitable! He’s treated like Brock Turner getting a six month sentence for “outercourse.”

If Excitable Boy hasn’t made the listener stop and take a shower at this point in the record, the listener is treated to the album’s radio hit, the well-traveled Werewolves of London. The horrors of the iconic single aren’t as real as Congolese warlords and certifiable teenagers: they’re well-dressed werewolves eating and maiming their way through the city. It’s certainly the most charming ballad to mythical creatures this


In contrast, Tenderness On The Block explores a woman’s departure into young adulthood. Terror is contrasted with innocence in the latter half this record.

The album closes with Lawyers, Guns and Money, the story of an entitled trust fund brat whose recklessness winds him up in a bad situation that even his rich father can’t get him out of. Inspired by a bizarre cab ride in Cuba, Zevon’s finale to Excitable Boy elegantly encapsulates the album’s incredibly whirlwind of blood, gore, bad decisions, and innocence.

No, Excitable Boy isn’t as overtly horror-influenced as an Alice Cooper record. It’s not The Ramones’ Pet Sematary. This album should be in your rotation all year, not just this week. With that said, there’s something about Excitable Boy that aligns with the spirit ofHalloween. It pokes fun at the macabre while embracing youthful innocence. It doesn’t shy away from ghosts, werewolves, and murderers. It’s a delightfully frightening excursion through one of the twentieth century’s best songwriter’s work and its eerie cast of characters remain poignant today.

Have thoughts on Excitable Boy? Did you rub your chest with pot roast in high school? Please let me know in the comments below or on Twitter @iambrettstewart.

Feature photo courtesy of Klaus Hiltscher.


NFL referee debacle costs everyone, except the NFL

NFL replacement referees cost the Green Bay Packers a win Monday night, and frustrations are reaching a boiling point. But while fans, players, and coaches are paying a price, the NFL itself isn't losing anything but the public relations battle.

Officials signal after Seattle Seahawks wide receiver Golden Tate pulled in a controversial last-second pass for a touchdown to defeat the Green Bay Packers 14-12 in Monday's NFL football game. Frustration with the NFL replacement referees reached a boiling point following the game, which many believe ended in an interception that would have given Green Bay, not Seattle, the win.

Joshua Trujillo/seattlepi.com/AP

View photo

Monday Night Football's controversial game-ending play between the Packers and Seahawks is only the latest flap involving the NFL's use of-103*b - 13. Determine 8*g(v) + 5*o(v).
-59*v - 4
Let g(h) = h. Let k(i) be the first derivative of -i**2/2 + 5*i + 53. Let b(n) = 3*g(n) + k(n). Let y(m) = -4*m - 11. Give 9*b(p) + 4*y(p).
2*p + 1
Let z = -196 - -199. Let h(d) = d**2 - 2*d. Let o(q) be the third derivative of -q**5/60 + q**4/24 - 3*q**2. Give z*h(a) + 5*o(a).
-2*a**2 - a
Suppose -6*z + 4*z + 4*t + 4 = 0, 0 = 4*z - 5*t - 14. Let u(i) = 9*i - 25. Let v(w) = 2*w - 6. Determine z*u(q) - 26*v(q).
2*q + 6
Let h(y) = 7*y**2 + 5. Suppose 0 = 2*p - 6*p - 20. Let v(b) = 10*b**2 + 7. Let u = 112


\[[@B35]\]. The phylogenetic tree was constructed using the neighboring-joining method. Numbers at each node are the percentage bootstrap values of 1000 replicates. The scale bar indicates the number of amino acid substitutions at each site.](1471-2229-13-100-1){#F1}

Amongst the NDB type proteins, prediction of mitochondrial targeting was less frequent (Figure [1](#F1){ref-type="fig"} and Additional file [2](#S2){ref-type="supplementary-material"}). This may be due to the fact that NDB proteins do not contain a cleavable N-terminus mitochondrial targeting signal which is the basis of the prediction programs used \[[@B23]\]. However, the majority (22 out of 29) of NDB proteins, ranging from Physcomitrella to Poplar also contain predicted PTS1 sequences. It is interesting to note that the predicted PTS1 sequences in both NDA and NDB proteins are not conserved in all species. In fact, in different species theproteins have been proposed presuming an exclusive mitochondrial localization. However, as shown in this study, and other studies \[[@B1],[@B44],[@B45]\], the targeting ability of a protein depends on the test tissue and the constructs used, and cell specificity cannot be ruled out, i.e. dual targeting may occur in specific types of cells. Previous studies analyzing the location of NDB1 in potato tubers concluded that there was no NDB1 in peroxisomes \[[@B46],[@B47]\]. This difference to this study may be due to several reasons, firstly, there is a difference between targeting and accumulation, and the specialized storage tissue of potato tubers may not be an ideal tissue to study the location of an enzyme, especially if stem/shoot phenotypes are being examined. Secondly there are a number of technical problems with the


Peroxisomes - blue.](1471-2229-13-100-8){#F8}

Methods
=======

Bioinformatic analyses
----------------------

Protein sequences for all Arabidopsis type II NAD(P)H dehydrogenase proteins were obtained from the TAIR website (<http://www.arabidopsis.org>) (NDA1; At1g07180, NDA2; At2g29990. NDB1; At4g28220, NDB2; At4g05020, NDB3; At4g21490, NDB4; At2g20800, NDC1; At5g08740) and used in BlastP \[[@B60]\] searches against *Volvox carteri, Chlamydomonas reinhardtii* (Chlamydomonas), *Physcomitrella patens*, *Selaginella moellendorffii*, *Oryza sativa*, *Zea mays*, *Vitis vinifera*, *Glycine Max*, and *Populus trichocarpa* protein databases using the Phytozome website (<http://www.phytozome.net>). Blastx searches were used in order to identify proteins from *Picea glauca* on the NCBI database (<http://www.ncbi.nlm.nih.gov>) \[[@B60]\]. The known sequences for the *Escherichia coli*, *Saccharomyces cerevisiae*, and *Synechocystis sp. PCC 6803* NADH dehydrogenases were downloaded from the NCBI website (<http://www.ncbi.nlm.nih.gov>). Predictions of subcellular localizations were carried out using Predotar \[[@B61]\], TargetP \[[@B62]\] and Wolfpsort \[[@B63]\]. The ATP predictor \[[@B64]\]ProjectSummary Forsomethingascomplexandmultifacetedasbacterialantibioticresistance(AR),ourdrugevaluation paradigmisstrikinglynarrowandhomogenous:MIC/MBCtestinginstandardizedbacteriologicmedia.We haveshownthatthisdrugevaluationparadigmisinadequate,evenmisleading,aschangesinthemedia conditionsoftheprocedureleadtodramaticallydifferentresults.Amoreholisticdefinitionofantibiotictherapy thatcentersonunderstandingantibioticactivityinsynergywithhostinnateimmunefactorssuchascationic antimicrobialpeptides(AMPs),serumandphagocyticcells(e.g.neutrophils)revealstherapeuticoptions unrecognizedinstandardtesting.TheproposedU01programrepresentsagroundbreakingapproachtouse systemsbiologyapproachesandinformmoreeffectiveantibioticutilizationinthecontextofhostinnate immunity.Weproposeto:1)buildaniterativesystemsbiologyworkflowthatintegratesmultipleexperimental andcomputationalapproachestogiveacomprehensiveassessmentofAR?and2)applythisworkflowtohigh prioritypathogenstosystematicallyelucidateARmechanismsandtheirconditiondependency.Theiterative workflowincludes:(i)omicsandphysiologicaldatageneration.Clinicallyisolatedstrainsoftheselected pathogenswillbegrownunderconventionaltesting(bacteriologicmedia)andmorephysiologicconditions (tissueculturemedia,serum,andinpresenceofAMPsandneutrophils)toprobeforadvantageousgainof activity.Theomicsdatatypescollectedare:DNAresequencing,RNAseq,andmetabolomics.(ii) Bioinformaticsanddatamodelinganalysisinvolvesthreeapproaches:bigdataanalysisfordataset dimensionalityandcoarsegrainedvariabledependenciesassessment,genomescalemodelingfor mechanisticelucidationandanalysis,andmachinelearningthatusesARrelatedmetadatatoclassifythe overallbiologicalfunctions.ThisanalysiswillleadtounderstandingofARmechanisms.(iii)Multiscale validationfromanimalmodels,tolaboratoryevolution,tocytology,togeneexpressionalteration,tostructural proteinanalysisofputativetargets.Thevalidationthusrangesfromhostbehaviortoatomisticdetailof ligandtargetinteractions.Theiterativeloopthencloses,comparingcomputationalpredictiontoexperimental outcomes.Falsenegativeandfalsepositivepredictionsarethenalgorithmicallyanalyzedbyahypothesis generatingfamilyofalgorithmsthatthenmakessuggestionsaboutwhatconditionstouseinthenextiteration oftheloop.Thepathogensthatwewillfocusonaremethicillinresistant?Staphylococcusaureus?(MRSA),the carbapenemresistantEnterobacteriaceae(CRE)Klebsiella?pneumoniae?and?Acinetobacterbaumannii,?and Pseudomonasaeruginosa?.Theteamofinvestigatorshasmadethefoundationalobservationsandledthe developmentofthetechnologiesonwhichtheiterativeworkflowisbased.Amultiandgenomescalemethods ofsystemsbiologyfulfillsrequirementsofRFAAI14064towhichitresponds.


Your Own

To administer the Sideline Dropstick you will need to build a dropstick and use a random number generator (there are several random number generator applications available for free download on smartphones)

Here's how to make a dropstick:

Supplies

7/16" dowel rod

Rubber ice
hockey puck

Friction tape (what one would use for ‘grip tape' to tape a tennis racquet. Should be a light color. I have used "Tourna" Grip Tape, green colored, in my research).

Standard push pin/thumbtack

Power drill with 3/8 inch bit

Wood saw and/or Leatherman tool

Wood glue

Superglue

Felt tip marker (a black "Sharpie" with a fine point works well; you need one with ink that is easy to see against the friction tape)

Instructions

Using the drill and 3/8 inch bit, drill into the puck, making sure not to drill all the way through.

Remove the rubbercreditor nation lending money to other countries. As a creditor nation, other countries owed more money to the United States than the United States owed to foreign countries. After 1970, the United States became a net debtor nation. As a debtor nation, the United States owes more money to foreign countiress than the foreign countries owe the United States. The United States is now the largest debtor among all nations. (Howard J. Sherman, E. K. Hunt, Reynold F. Nesiba, Phillip Anthony O’Hara. Economics: An Introduction to Traditional and Progressive Views, 7th edition. M.E. Sharpe, 2008, p. 175)

It should be pointed out that although others believe that the line from an overall creditor to debtor nation happened in the 1980s (as opposed to annually which began around 1971), the


all time.

Just over 44 years ago, on January 22, 1973 the United States Supreme Court decided to overturn state laws prohibiting abortion in a case known as Roe vs. Wade. Now look at the following:

In real terms, as mentioned above, US growth in the 21st century seems to have fallen back to medieval levels. Why?…Because the economy failed to produce real growth. After 1973, wages, for example, adjusted for inflation, went nowhere. (Bonner B. Economic Growth in the Internet Age. Daily Reckoning, June 23, 2011) The typical working stiff earns less real money today than he did 40 years ago. (Bonner B. Economic Long Live the 1%. Daily Reckoning, November 25, 2011)

Whether counting from 1967 or 1973, something changed. Abortion is not good. Here is an estimate offree for those that want them. Does freedom of choice include the right to shed innocent blood? What has happened to the economy of the USA since abortions became legalized? What has happened to incomes since that time? How many babies have been killed since the Roe vs. Wade decision in 1973? Is there a cost to abortion beyond the financial and emotional? What does the Bible teach? What does the Bible prophesy? Dr. Thiel addresses these and other questions. This is a video.

Cross-dressing and other assaults against your children. What should you do? Is there an agenda to turn your children and/or grandchildren away from biblical morality and towards practices promoted by homosexuals? What does the Bible teach about cross-dressing? What should parents do? If there is


an agenda, what has been going on? There are also three YouTube videos related to this, titled Transgender ‘Woe to those who call evil good’ and Cross dressing and Other Assaults Against Your Children and USA pushing gender confusion.

The Bible Condemns Homosexuality “Same-sex marriage” for “gays” and lesbians is becoming more acceptable to many. What does the Bible teach about homosexuality? Can homosexuals change? A related video sermon is titled: What Does the Bible Really Teach about Homosexuality?

Pornography: A scourge on society Is pornography harmless fun? Does the Bible teach anything about it? What are the views of some involved with it? A related sermons is titled: Pornography, False Comfort, and False Religion. Here a shorter YouTube video Pornography: Harmless Fun or a Scourge on Society?

The Ten CommandmentsReflect Love, Breaking them is Evil Some feel that the ten commandments are a burden. Is that what Jesus, Paul, Peter, James, and John taught?

Christian Repentance Do you know what repentance is? Is it really necessary for salvation? A related sermon is also available titled: Real Christian Repentance.

Just What Do You Mean — Repentance? Do you know what repentance is? Have you truly repented? Repented of what? Herbert W. Armstrong wrote this as a booklet on this important subject.

When You Sin: Do You Really Repent? This is an article by Charles F. Hunting. A related sermon is Confess to God and truly repent.

Anglo – America in Prophecy & the Lost Tribes of Israel Are the Americans, Canadians, English, Scottish, Welsh, Australians, Anglo-Saxon (non-Dutch) Southern Africans, and New Zealanders


Henao

Henao is a Spanish surname. Notable people with the surname include:

Alexandra Henao (born c. 1970), Venezuelan cinematographer and film director
Carolina Colorado Henao (born 1987), Colombian swimmer
Jorge Henão (born 1962), Venezuelan swimmer
Juan Carlos Henao (born 1971), Colombian footballer
Mauricio Henao (born 1987), American actor
Sergio Henao (born 1987), Colombian cyclist

Category:Spanish-language surnamesheavy metal concentration in sediment. Due to the absence of sediment background values for Honghu Lake, soil background values for Hubei Province were used as a reference, and the values of Cr, Cu, Zn, Pb and Cd were 86.0 mg/kg, 30.7 mg/kg, 83.6 mg/kg, 26.7 mg/kg, and 0.172 mg/kg, respectively (CNEMC 1990) \[[@B44-ijerph-15-00207]\].

*I~geo~* is classified into seven levels as follows: (1) *I~geo~* ≤ 0, uncontaminated; (2) 0 \< *I~geo~* ≤ 1, uncontaminated to moderately contaminated; (3) 1 \< *I~geo~* ≤ 2, moderately contaminated; (4) 2 \< *I~geo~* ≤ 3, moderately contaminated to heavily contaminated; (5) 3 \< *I~geo~* ≤ 4, heavily contaminated; (6) 4 \< *I~geo~* ≤ 5, heavily to extremely contaminated; and (7) *I~geo~* \> 5, extremely contaminated.

### 2.4.2. Potential Ecological Risk Index {#sec2dot4dot2-ijerph-15-00207}

The potential ecological risk


metals, Cd had the higher proportion of acid-extractable fraction (19.41--31.47%) while mainly occurred in residual fraction (53.57--72.55%). The acid-extractable fraction is very sensitive to water environment change, which be probably released in acidic or neutral condition and easily transfer into aquatic organisms. It showed that Cd in sediment from sampling sites might have a relatively higher biological toxicity than the other metals.

3.4. Fuzzy Comprehensive Risk Assessment {#sec3dot4-ijerph-15-00207}
----------------------------------------

According to the analysis above, results were obtained by different evaluation indexes such as SQGs, PEI and RAC. The enrichment degree compared with SQGs decreased in the order of Cr \> Cu \> Zn \> Pb \> Cd, average ecological risks were decreased in the order of Cd \> Cu \> Pb \> Cr \> Zn, and the average bioaccessibilities decreased indifferent levels using fuzzy mathematics, then fuzzy results of PEI and RAC were endowed with weights, and finally comprehensive risk can be calculated as in Equations (5) to (16). Combining [Table 1](#ijerph-15-00207-t001){ref-type="table"} and [Table 2](#ijerph-15-00207-t002){ref-type="table"}, according to arithmetic calculation from Equations (1) to (16), an assessment matrix based on average values of Cr, Cu, Pb, Zn and Cd is as follows:$${R_{Cr} = \begin{pmatrix}
\begin{matrix}
1 & 0 & 0 & \begin{matrix}
0 & 0 \\
\end{matrix} \\
\end{matrix} \\
\begin{matrix}
1 & 0 & 0 & \begin{matrix}
0 & 0 \\
\end{matrix} \\
\end{matrix} \\
\end{pmatrix},}~{R_{Cu} = \begin{pmatrix}
1 & 0 & 0 & 0 & 0 \\
0.507 & 0.493 & 0 & 0 & 0 \\
\end{pmatrix}},$$

R

P

b

=

(

1

0

0

0

0

0.831

0.169

.

0

0

0

)

,

R

Z

n

=

(

1

0

0

0

0

0.636

0.364

0

0

0

)

,

R

C

d

=

(

0.106

0.894

0

0

0

0

0.282

0.718

0

0

)

Based on Equation (6), average comprehensive risks of heavy metals in sediments of Honghu Lake were as follows: *Risk~Cr~* = (1, 0, 0, 0,


[Figure 4](#ijerph-15-00207-f004){ref-type="fig"}b, for Cu, there were 81.25% and 18.75% of areas under low risk and moderate risk, respectively. The areas around S1, S12 and S14 of South Honghu Lake were of concern. Specifically, the membership degrees in S1, S3, S9, S11 and S16 were around 50% ([Figure 5](#ijerph-15-00207-f005){ref-type="fig"}b). It is necessary to pay more attention to these sites during corresponding decision making. The comprehensive risks of Cu were in the descending order of S12 \> S14 \> S1 \> S11 \> S16 \> S9 \> S3 \> S4 \> S10 \> S2 \> S8 \> S7 \> S6 \> S15 \> S5 \> S13.

Comparing with Cd and Cu, the comprehensive risks of Cr, Pb and Zn were at lower level. Comprehensive risks of Cr and Zn in sedimentsor even mislead decision-makers. Thus, the fuzzy comprehensive risk assessment model was established. Average comprehensive risks of heavy metals decreased in the order of Cd (considerable risk) \> Cu (moderate risk) \> Zn (low risk) \> Pb \> Cr. Cd and Cu were determined as the contaminants of most concern among the five metals, which differed to a certain extent from results of *I~geo~* and SQGs method. For Cd, the central part of South Honghu Lake (S4, S5, S6, S9 and S12), east part of North Honghu Lake (S1) and outlet of outlet of Honghu Lake (S10) were the priority control areas. Notice that 57.14% Cd samples, which belonged to considerable risk, need to be paid more attention for their 40--50% membership degrees. For Cu, the areas around


integrated. In addition, “cabling” must be prescribed when the network channels are allocated in a fixed manner to ensure redundancy. The connections between the participants and the hardware side must be noted exactly. Faulty configurations can result in service interruptions with serious consequences, and expensive troubleshooting.trick on Kathy to accept his demands? Faking Star Wars says yes. Expect an announcement of an Obi-Wan Kenobi series or movie for Disney+ at D23 later this month!

Visual simulation of Ewan with his huge novelty paycheck.

As always, stay tuned to FakingStarWars.net for all the finest Star Wars comedy, parody, and satire in the galaxy. Don’t forget to follow us on Twitter, Instagram and Facebook and subscribe to our podcast on iTunes or Google Play for even more unbelievable news from a galaxy far, far away. Also, consider supporting us on Patreon… for as little as a buck a month, you can help us fake harder, better, faster, stronger.

-Link “Vox” Voximilian


Chromosome Segregation: Reconstituting the Kinetochore.
Faithful chromosome segregation is accomplished by attachment of chromosomes to spindle microtubules using the kinetochore. In a major step forward in understanding the functional and structural complexity of kinetochores, a 21-subunit human centromere - kinetochore complex has been reconstituted entirely from purified components, recreating the connection between DNA and microtubule.format, according to manufacturer's instructions (Southern Biotech, Birmingham, AL, USA). Western blots were as described \[[@B11-toxins-05-02212]\]

2.5. Capture ELISA
------------------

The capture ELISA previously described \[[@B11-toxins-05-02212]\] was used with the following modifications. Microtiter plates were coated with capture antibody, 100 µL of a 0.5 µg/mL solution of mAb in 0.05 M sodium carbonate buffer, pH 9.6 overnight at 4 °C. Non reacted binding sites were blocked by adding 3% non-fat dry milk in TBST (NFDM-TBST). Toxin standards in TBST, or spiked samples were added (100 µL/well) and the plates incubated at 37 °C for 1 h. Next, detector antibody (each mAb was labeled with biotin \[[@B11-toxins-05-02212]\] was added (100 µL at 5 µg/mL in NFDM-TBST), the plates incubated for 1 h at 37 °C, washed. One hundred µL of a 1/20,000


mAbs were isolated. However, none of the antibodies so produced effectively bond toxin in solution under physiological conditions, and thereby were not useful as a capture antibodies in a sandwich ELISA. Furthermore, none of the mAbs produced in this earlier study were able to function as a detector antibody (even though they bound toxin in ELISA and on Western blots \[[@B13-toxins-05-02212]\]. A single mAb able to capture toxin from solution eventually was identified but only after incorporating a double-capture ELISA screen \[[@B13-toxins-05-02212]\]. In the studies described here the double-capture ELISA screen was used in an effort to identify additional capture and detector antibodies and useful antibody pairs for measurement of BoNT/B.

Following cell fusions, putative capture mAbs were trapped on microassay plates pre-coated with anti-mouse Ig (Fc) specific antiserumRUSSIA and the US have both flown nuclear bombers near North Korea as tensions grow over tyrant Kim Jong-un's atomic threats.

President Donald Trump sent a nuclear-capable B-2 stealth bomber from Whiteman Air Force Base in Missouri on a long-range mission to the Pacific this weekend.

4 The US military sent a nuclear-capable B-2 stealth bomber to the Pacific area of operations. File picture Credit: Getty - Contributor

4 US and Japanese jets escorted Russia’s missile-carrying Tupolev-95MS strategic bombers during their flights. File pictures Credit: Getty - Contributor

How big is North Korea's army and what missiles does Kim Jong-un have?

And the Russian Defence Ministry today announced that US and Japanese jets escorted Russia’s missile-carrying Tupolev-95MS strategic bombers during flights over the Sea of Japan and the Pacific.

A spokesman said: "Two strategic


to C4 diol with a sufficient amount of an acid (either organic or inorganic) to adjust the pH of the composition to below 4.6. This is demonstrated effective in topically treating lesions caused by herpes simplex virus. It is also proposed that the composition may be effective at ameliorating the symptoms of a common cold with intranasal application. No mention is made of the use of the composition on an area of the face to prevent access for active viral particles to mucosal membranes to reduce transmission of or severity and duration of viral illnesses.
Brown-Skrobot, et al. (U.S. Pat. No. 4,975,217) disclose a method of inactivating viruses and bacteria through the application of a combination of an organic acid and an anionic surfactant, with or without an alcoholEmission control systems are well known in the art for connecting an exhaust suction hose to the exhaust or tail pipe of a vehicle. One such system is the SYMPLAIR.TM. S20 vehicle emission capture system manufactured by Tykron Inc. of Grimsby, Ontario. This prior art system includes ductwork which extends from one side of a swivel ball to a fan which in turn discharges fumes from within a structure. The other side of the swivel ball is connected to a flexible exhaust hose which has a free end spaced away from the swivel ball. An intermediate portion of the flexible hose is supported by a spring take-up reel carried by a trolley on a suitable track. The free end of the exhaust hose of the SYMPLAIR.TM. S20 vehicle


emission capture system carries a pliers-like clamping device which may be used to secure the free end of the flexible hose to the exhaust pipe of a vehicle. The pliers-like coupling device has been developed so that as the vehicle exits from the structure the coupling device will disconnect from the exhaust pipe of the vehicle. This type of system allows mobility of a vehicle over a limited range within a structure, and has the advantage of discharging exhaust fumes from within the structure when the vehicle is operated within the structure. The SYMPLAIR.TM. S20 vehicle emission capture system finds particular application in fire stations where it is desirable that vehicles should be exhausted up to the point where they leave the building, thereby preventing contamination of theflexible exhaust suction hose carries an electromagnet which is adapted to be coupled to a specific site on the vehicle, there being a leaf spring extending from the area of the electromagnet to free end of the flexible hose, the leaf spring being designed to maintain the free end of the suction hose about the end of the exhaust pipe of the vehicle. Although this form of device eliminates some of the disadvantages of the prior art, it adds complications in that the electromagnet does not always properly disconnect as the vehicle is exiting the structure. In addition, such a device tends to be more expensive than other prior art.
One of the disadvantages of the SYMPLAIR.TM. S20 vehicle emission capture system, as well as the system shown in


needs to be “ready” for this behavior by planning a program that allows a lot of play and physical activity. If she cannot do so (whatever the reason may be), then in a very real sense this failure is not the children’s responsibility. Among older students, the second, teacher-oriented meaning of readiness makes sense as well. If a teacher has a student with a disability (for example, the student is visually impaired), then the teacher has to adjust her approach in appropriate ways—not simply expect a visually impaired child to “sink or swim.” As you might expect, this sense of readiness is very important for special education, so I discuss it further in Chapter 5 (“Students with Special Educational Needs”). But the issue of readiness also figures importantlywhenever students are diverse (which is most of the time), so it also comes up in Chapter 4 (“Student Diversity”).

Still another result of focusing the concept of learning on classrooms is that it raises issues of usefulness or transfer, which is the ability to use knowledge or skill in situations beyond the ones in which they are acquired. Learning to read and learning to solve arithmetic problems, for example, are major goals of the elementary-school curriculum because those skills are meant to be used not only inside the classroom, but outside as well. We teachers intend, that is, for reading and arithmetic skills to “transfer”—even though we also do our best to make the skills enjoyable while they are still being learned. In the world inhabited by teachers,


is (a “false negative”). When testing a specific hypothesis, scientists run statistical checks to work out how likely it would be for data which seem to support the idea to have come about simply by chance. If the likelihood of such a false-positive conclusion is less than 5%, they deem the evidence that the hypothesis is true “statistically significant”. They are thus accepting that one result in 20 will be falsely positive—but one in 20 seems a satisfactorily low rate.

The next part is incredibly wonky and, even simplified for readers of The Economist, a bit hard to follow.

In 2005 John Ioannidis, an epidemiologist from Stanford University, caused a stir with a paper showing why, as a matter of statistical logic, the idea that only one such paper into do but not the math behind them. And that makes us oblivious to errors.

Statisticians have ways to deal with such problems. But most scientists are not statisticians. Victoria Stodden, a statistician at Columbia, speaks for many in her trade when she says that scientists’ grasp of statistics has not kept pace with the development of complex mathematical techniques for crunching data. Some scientists use inappropriate techniques because those are the ones they feel comfortable with; others latch on to new ones without understanding their subtleties. Some just rely on the methods built into their software, even if they don’t understand them.

Things have come a long way since I was in graduate school twenty years ago. At that point, doing complex statistical analysis was a much more labor-intensive


February 13, 2008

Planetfesto

A "manifesto" about our unique planet. I came across it this morning and couldn´t keep from writing about it. They say "Let´s build a ribbon around the whole world". The homepage of Planetfesto brings a beautiful presentation made of statements left from people all around the world proposing ways to improve and protect the planet. It´s wonderful to see so many people involved in this wonderful project. I left my statement too and now I invite you to do the same. To be part of the ribbon click on DO YOUR PIECE, select a picture and answer the questions.as a dour sort and is taken aback by his permanent smile and fixedly cheery demeanor.Establishing Character Moment : Performing a sick grind on a railing like Latula, only to land flat on his face.Occidental Otaku : Or the Alternian form of occidental, anyway.Thankfully, she's very sweet and friendly with humans, even if it is only an act.Morality Pet : The first thing that Meenah has been disturbed by of the Condesce's history was her treatment of the Helmsman.Gamzee and Kurloz definitely have a resemblance, as do Meulin and Nepeta and Aranea and Vriska.Holier Than Thou : A secular version!Not that it stops her from trying to kill his lusus and making his afterlife misery.Pink Means Feminine : Aversion.It wound up backfiring horribly.Not to mention that all of


viewing angle.
To overcome this problem of directional variance in the LCD device, various proposals have been disclosed. For example, Japanese Laid Open Patent No. H9-19740 discloses an LCD device having a viewing angle control structure in which collimated light is incident on two liquid crystal display bonded to each other.
Hereinafter, a method for controlling a viewing angle in an LCD device according to the related art will be explained as follows.
FIGS. 1B and 1D are cross sectional views schematically illustrating an LCD device having two liquid crystal displays bonded to each other, on which collimated light is incident.
First, collimated light is incident on a first LCD panel 1. The first LCD panel 1 is identical in structure to a related art LCD panel that displays images.
Then, light fromnot some weird personal level scenario that plays upon my self esteem. So, I settled into the high. . .and holy fucking shit!!! One of my favorite artists has always been Alex Grey, and as I looked at the three individuals in my kitchen (my friends) they, along with the entire scene around them, began taking on the colorful effect that Grey’s painting Bardobeing has with very contoured, vertical, psychedelically colored “lines” covering everything! It was beyond amazing and probably the most beautiful thing I’ve ever witnessed to this day. I did begin to detect some “essences” of the people, such as emotional and thought patterns, but the drug was moving way too fast to really grasp onto anything and I ambled on into the living room.

The most


dragon lizard!!! Shamans of most cultures respect lizards and reptiles as keepers of great knowledge. I wasn’t getting anything from this lizard, but he sure as shit roused me! He was at the edge of his branch, in the tank which was lit at the time, and was staring intently right at me. Those lizards will sometimes sleep for a day or two, and he was on a sleep cycle, so it was strange enough that he was so alert! Since then he has more than once awakened me from slumber to tell me he was hungry! Alarms suck, but it’s just down right weird when I was awoken by the flashing image of a giant lizards face in my dreamscape!

Anyway, so that was the extent of myimport os
import numpy as np
import cv2
from HPE.config import cfg
import random
import time

def data_augmentation(trainData, trainLabel, trainValids, segms=None):
    trainSegms = segms
    tremNum = cfg.nr_aug - 1
    gotData = trainData.copy()
    trainData = np.append(trainData, [trainData[0] for i in range(tremNum * len(trainData))], axis=0)
    if trainSegms is not None:
        gotSegm = trainSegms.copy()
        trainSegms = np.append(trainSegms, [trainSegms[0] for i in range(tremNum * len(trainSegms))], axis=0)
    trainLabel = np.append(trainLabel, [trainLabel[0] for i in range(tremNum * len(trainLabel))], axis=0)
    trainValids = np.append(trainValids, [trainValids[0] for i in range(tremNum * len(trainValids))], axis=0)
    counter = len(gotData)
    for lab in range(len(gotData)):


  params.leftMargin = imagenum * xspaceforeachimage;
            params.topMargin = 0;
        } else {
            params.leftMargin = (imagenum - 39) * xspaceforeachimage;
            params.topMargin = topMargin;
        }
    } else if (orientation.contentEquals("portrait")
            || orientation.contentEquals("reverse portrait")) {
        params.height = imagewidth;
        params.width = imageheight;
        imageButton.setImageResource(R.drawable.imagebacklaid);
       decision that was based on an unreasonable determination of the facts in light of the evidence presented in the State court proceeding." A state court's decision is deemed contrary to clearly established federal law if it reaches a legal conclusion in direct conflict with a prior decision of the Supreme Court or if it reaches a different conclusion than the Supreme Court based on materially indistinguishable facts. Williams v. Taylor, 529 U.S. 362, 120 S.Ct. 1495, 1519-20, 146 L.Ed.2d 389 (2000). A state court's decision constitutes an unreasonable application of clearly established federal law if it is objectively unreasonable. Id. at 1521.

13
Further, state court findings of fact are presumed to be correct, and the petitioner has the burden of rebutting the presumption of correctness by clear and convincing


586, 98 S.Ct. 2954, 57 L.Ed.2d 973 (1978); Eddings v. Oklahoma, 455 U.S. 104, 102 S.Ct. 869, 71 L.Ed.2d 1 (1982); McCleskey v. Kemp, 481 U.S. 279, 304, 107 S.Ct. 1756, 95 L.Ed.2d 262 (1987)). Therefore, the defendant's mental retardation is a fact of consequence to the determination of the death penalty action and any evidence that makes its existence more probable is relevant mitigating evidence of that mental condition. Because there plainly is evidence in the record of mental retardation in Tennard's character and background, the court of criminal appeals's unreasonable finding to the contrary in adjudication of Tennard's claim "resulted in a decision that was based on an unreasonable determination of the facts in light of the evidence presented in the State court proceeding." 28 U.S.C.be able to consider and give effect to any mitigating evidence relevant to a defendant's background and character or the circumstances of the crime.

46
Id. at 327-28, 109 S.Ct. 2934 (internal citations and quotations omitted).

47
Tennard is entitled to relief under 28 U.S.C. § 2254(d)(1) because the decision of the Texas Court of Criminal Appeals rejecting his Penry I claim is based on rationales that were rejected generally and specifically by Penry I. In general, the Supreme Court in Penry I agreed with Penry's argument "that his mitigating evidence of mental retardation and childhood abuse has relevance to his moral culpability beyond the scope of the special issues, and that the jury was unable to express its `reasoned moral response' to that evidence in determining whether death was the appropriate


damn, a computer can correct your voice. Remember Cher?

It used to be that in order to make it in the music business, you must spend at least a decade on practice, practice, practice. In fact, most professional musicians practiced so much they ended up flunking out of school, because they were playing 15 hours/day. Now, you buy a keyboard, read the instruction manual, and spend a couple of weeks learning how to use it, you can be a star. That cheapens the whole industry.

Let's start a grass-roots campaign to protest the declination of music. How do we do it? Insist that the Grammy's differentiate between music and computer-aided "sounds"? Beat up anyone we see listening to that sh&t? What do we do?

Got to say amen to that asQ:

if else loops and jquery not working in hot or cold app

I wrote JavaScript for a hot or cold app and I'm having issues with the loops that check if the user's guess is hot of cold returning text to the feedback id. The function that resets everything when the "New Game" button is clicked is also not working. Let me break it down:

In the checkGuess function, the second if..else loop that returns the apprioriate text ("Hot" "Cold" etc.) into the feedback id is not working after the first guess is entered. For any subsequent guesses, the text in the feedback ID does not change.
The function to re-set the game when you click the new game button is not working. I do not want to refresh the


 var listGuess = '<li>' + guess + '</li>'; // listGuess is user's guess with some list tags
    $('#guessList').append(listGuess); // add user's guess to the list
    $('#userGuess').val(''); // empty user guess field so they can add a new guess
    countGuess(); // run countguess function
    checkGuess(); // pass user's guess through checkguess function
  });

  // reset game

  $(".new").on('click', function(e) {// when new game button is clicked do the following
    e.preventDefault();
    // Empty Guesses
    $('#guessList').innerHTML = ""; // empty listguess field
    // Reset Guess number on page
    $('#count').text = "0";
    //Reset Guess Count in javascript
  about 2-3 inches of simmering water.

Continue to warm, stirring gently or carefully shaking the jar every 1-2 minutes to encourage the ingredients to melt. When you have a smooth, golden liquid, remove from heat. At this point you can add your essential oils or vitamin E as the mixture begins to cool, mixing carefully to combine.

Pour into a mold of your choice. You can likely find a variety of themed molds at your local grocery or craft store or simply pour mix into the bottom of a parchment paper-lined baking pan.

Once the lotion has cooled and hardened completely, gently pop out of the molds or cut into bars if you used a square pan. The bars should stay solid at room temperature, but will melt slighlty when applied


Novel LaBO3 hollow nanospheres of size 34±2 nm templated by polymeric micelles.
Novel lanthanum borate (LaBO(3)) hollow nanospheres of size 34±2 nm have been reported for the first time by soft-template self-assembly process. Poly(styrene-b-acrylic acid-b-ethylene oxide) (PS-PAA-PEO) micelle with core-shell-corona architecture serves as an efficient soft template for fabrication of LaBO(3) hollow particles using sodium borohydride (NaBH(4)) and LaCl(3)⋅7H(2)O as the precursors. In this template, the PS block (core) acts as a template of the void space of hollow particle, the anionic PAA block (shell) serves as reaction field for metal ion interactions, and the PEO block (corona) stabilizes the polymer/lanthana composite particles. The PS-PAA-PEO micelles and the resulting LaBO(3) hollow nanospheres were thoroughly characterized by dynamic light scattering (DLS), transmission electron microscope (TEM), X-ray diffraction, magic angle spinning-nuclearwhich not only can reduce the number of parts to simplify the structure of the throttle-opening sensor but also can reduce the size of the whole throttle-opening sensor.
According to the present invention as set forth in a first aspect, there is provided a throttle-opening sensor, comprising a detect shaft rotatable about an axis in conjunction with a throttle grip, a pair of rotation terminals respectively disposed on different positions in the same circle with the rotation axis of the detect shaft as a center thereof, the pair of rotation terminals being rotatable together with the detect shaft, first and second contact pieces disposed on each of the rotation terminals at predetermined intervals in a rotation-radius direction of the pair of rotation terminals, a printed circuit including a first


(+ 95% CL) was 7.90 + 2.96% of the mean for the 31 data series. In order to explore the extent of variability of standard deviations in relation to the mean, we calculated the coefficient of variation. Due to the fact that standard deviation is divided by the mean, a plot of means versus coefficients of variation shows a decreasing linear relationship on a log--log scale when standard deviations remain fairly constant ([Fig. 5](#F5){ref-type="fig"}).

To characterize the periodicity of the strongest stress peaks on the larva, we define the "recurrent interval" as the mean time interval between two successive major maxima of the velocity measured within the total measurement period. A major maximum is a local maximum which deviates less than ± 0.01 m s^−1^ from the global velocitymaximum in the total measurement interval. The recurrent interval within each of the 31 data series is an upper bound of hydraulic stress impacts faced by the larvae and ranged from 1 to 45 s (mean ± 95% CL = 15.00 ± 5.26 s). Flow maxima (mean ± 95% CL) were 0.04 ± 0.01 m s^−1^ higher than the respective mean velocities (range 0.03--0.07 m s^−1^). The duration of velocity measurements (resolution Δ *u* = ± 0.01 ms^−1^) had no significant effect on the recurrent intervals of absolute maxima (Mann--Whitney U-test; *P* \> 0.05). However, there was a significant (*P* = 0.001) negative relationship between the frequency of velocity maxima per second and the deviation of maxima from mean velocities of the respective time series: the higher the


of organismic *R* of the 31 data series, only a single data point satisfied *R* \< 500. In addition to hydraulic stress experienced by the larvae themselves, they generate additional turbulent fluctuations in their wake, thereby influencing the hydraulic field in their vicinity.

Discussion {#S9}
==========

For remaining stationary on the stream bed and to prevent drift entry, benthic organisms have to resist hydraulic stress which is based both on mean flow, strongly modified by fluctuations of the velocity field. In order to get information on both components, measurements consisting of sampled data series lasting for extended periods of time are necessary. The best method for time-resolved velocity measurements would be to use hot wire velocimetry. However, such devices are rather fragile, and the probe may fail if it runs dryhigh as pressure plus viscous drag. On the other hand, *Ecdyonurus* sp., another flattened mayfly species, is able to produce negative hydrodynamic lift forces by means of its large head shield which can be used to direct the flow in such a way as to press the body against the substrate. In benthic animals that are less or not at all dorsoventrally flattened, pressure drag by far outweighs lift force. For example, in the plecopteran *Perla bipunctata* Pictet 1833, drag was found to be 0.25 mN, but lift force was actually zero at a current speed of 40 cm s^−1^ ([@R41]), a situation which is also applicable to *Drusus biguttatus*.

The drag coefficient *C* ~d~ is defined as the ratio of the actual measured drag force to the reference


at larval positions \# 4, 6, and 9 where 7--8 additional measurements were conducted, as shown in [Fig. 1](#F1){ref-type="fig"}

[^1]: Handling editor: Verónica Ferreira
       1

       “The essential elements of a drug distribution conspiracy under 21 U.S.C. § 846

are: (1) a shared unity of purpose, (2) an intent to achieve a common goal, and (3) an

agreement to work together toward the goal.” United States v. Iglesias, 535 F.3d 150,

156 (3d Cir. 2008) (quoting United States v. Bobb, 471 F.3d 491, 494 (3d Cir. 2006))

(internal quotation marks omitted). However, “a simple buyer-seller relationship, without

any prior or contemporaneous understanding beyond the sales agreement itself, is

insufficient to establish that the buyer was a member of the seller’s conspiracy.” United

States v. Gibbs, 190 F.3d 188, 197 (3d Cir. 1999) (citations omitted). Among the factors

we have considered in determining whether a conspiracy has been shown


is her name?" "Broomhilda." " What?" " Broom-hilda." " Broomhilda?" " Hm-mm." " Were her owners German?" " Yeah, how you know?" "She wasn't born on the Carrucan plantation." "She was raised by a German mistress, the Von Shafts." "She speak a little German, too." " Your wife?" " Hm-mm." "When she was little, her mistress taught her so she'd have somebody to speak German with." "Well, let me get this straight." "Your slave wife speaks German and her name is Broomhilda Von Shaft?" "Yep." "They call me Hildi." "When we gain access to these plantations, we'll be putting on an act." "You'll be playing a character." "Hm?" "No?" "During the act, you can never break character." "Do you understand?" "Yeah." "Don't break character." "And your character isyourself somethin' cool to drink." "Hm-mm." "Oh, maybe while we discuss business, you could provide one of your loveliest black creatures to escort Django here around your magnificent grounds." "Oh, well, absolutely!" "Uh, Betina." " Yessir, Big Daddy?" " Uh..." "What's your Jimmie's name again?" " Django." " Django." "Betina, sugar, could you take Django there and take him around the grounds here and show him all the pretty stuff." "As you please, Big Daddy." "Oh, Mr. Bennett, I must remind you, Django is a free man." "He cannot be treated like a slave." "He... within the bounds of good taste," "He must be treated as an extension of myself." " Understood, Schultz." "Betina, sugar?" " Yes'm?" "Django isn't a slave." "Django is a free man, you understand?"


"You all wanna follow me?" "How long have you been associated with Mr. Candie?" "Oh, Calvin's father and I were about 11 when we went to boarding school together." "Calvin's father's father put me through law school." "One could almost say I was raised to be Calvin's lawyer." "One could almost say youse a nigger." "What did you say?" " I said..." " Nothing, he's just being cheeky." "Uh, anything else about Mr. Candie that I should know before I meet him?" "Yes, he is a bit of a Francophile." "What civilized people aren't?" "And he prefers Monsieur Candie to Mr. Candie." "He doesn't speak French." "Don't speak French to him, it'll embarrass him." "Get back on top, now!" "Turn around!" "There you go." "Why do you wantantagonizing my guest." "Hoot!" "Get back up on your horse." "He broke my collarbone!" "For God's sake, somebody please help Hoot here back up on his goddamn horse." " Yessir, boss." " Oh, now you are one lucky nigger." "You better listen to your boss, white boy." "Oh, I'm gonna go walking in the moonlight with you." "You wanna hold my hand?" "Willie, take us home." "Start moving!" "Head 'em out!" "You got a problem with your eyeball, boy?" "No, sir." "You want a boot heel in it?" "No, sir." "Then you keep your goddamn eyeballs off me." "You flash that bad look at me again, I'll give you a reason not to like me." "Now move, nigger!" "You niggers are gonna understand something about me." "I'm worse


right, doctor." "That name do have pan-ass." "Hm." "Hildi, top my drink off." "So, Hildi, how you like servin' at the big table in The Big House, huh?" "When Monsieur Candie talk to you, you answers." " I like it a lot, Monsieur Candie." " Hm-mm." "It's a lot better than sizzlin' in that Hot Box or dragging' your ass through a bramble bush." "But maybe it's not quite as much fun as gettin' to pleasure all them Mandingos," " huh, sugar bear?" " Oh, Lord, she like them niggers." " Sure do." " Like Samson?" "Huh?" "No, sir." "You know, Monsieur Candie, the doctor here might be interested in seeing' Hildi's peeled back, seein' as how they don't have many niggers where he come from." "Dr. Schultz,throat and it wouldn't have taken me no 50 years to do it, neither." "But he never did." "Why not?" "You see, the science of phrenology is crucial to understanding the separation of our two species." "In the skull of the African here, the area associated with submissiveness is larger than any human or any other subhuman species on planet Earth." "If you examine this piece of skull here you will notice three distinct dimples." "Here, here and here." "Now if I was holding the skull of an Isaac Newton or Galileo, these three dimples would be found in the area of the skull most associated with... creativity." "But this is the skull of Old Ben." "And in the skull of Old Ben, unburdened by genius, these three