completely since I got all the funding for the projects, infrastructures and negotiate it hard with the companies, so I think I should deserve it a bit more, but I know that with this I will have problems in the group. Of course, I should have written everything down, the regulations, before starting the projects, but now it is too late. In order to solve this I thought about preparing a document, in which everybody writes down what they think they did, and how that part contributed to the invention. Then I think we could start a reasonable discussion, so people that did less, could not say the opposite, and finally we would reach an agreement. Another solution I thought would be to leave my University to decidecompiler
inserts `malloc` (or whatever) calls, and ensures that every variable created
is either `free`d exactly once after it becomes unreachable or is added to the
set tracked by the GC (or is a constant - especially pertinent with strings).
With (hidden) local variables to track control flow when different branches
cause different allocations.)

~~~
aikah
So basically one needs to re-implement smart pointers in Javascript, right ?

What are the alternative to js style GC,for a language that wouldnt want to
the developper to use manual memory allocation.I've heard about ARC.Are there
other known architectures?

~~~
TheLoneWolfling
As I said: a pauseless GC _with a smart language implementation_ would be
fine. ARC can work, but either requires programmers to prevent loops or needs
a GC regardless.

Object pools at the language level would be an alternative. (I.e. every object
is allocated in a "pool", including


a
popular website, or vice versa. Although in this particular case, I don't
think anybody else implements performance.memory, so there would be no easy
way for Gmail to track memory usage in other browsers.

Disclaimer: I work on Firefox and am speaking for myself, etc.

------
corysama
> Anecdotes of Gmail tabs consuming multiple gigabytes of memory on resource-
> constrained laptops and desktops were being heard increasingly frequently

You know, I think I recall being able to run quite nicely featured GUI mail
clients and IRC clients simultaneously on a Pentium 90 with 16 megs of RAM.
And, I expect those clients had an order of magnitude less developer effort
put into them compared to the GMail client-side code. Meanwhile, I'm quite
confident that Gmail team is composed of very, very smart developers. So, what
am I missing? Why does GMailrequire two orders of magnitude more resources?

~~~
tambourine_man
I often make this kind of argument as well, but the demands we put an email
client through these days are nowhere near what such a machine could handle.

I have around 80.000 messages in my inbox, most of them with attachments
around 10MB, and I can browse and search them instantly.

Then again, I mostly use Gmail's backend, my preferred interface is Mail.app

------
rokhayakebe
Gmail still slow.

Unrelated: Why haven't Google implemented a Google.com-quality-level search
for email?

~~~
napoleond
Gmail's email search is already the best in the space, by far. I'm sure there
are improvements to be made, but zero external pressure to make them.

~~~
lostlogin
Gmail looks particularly good after 5 mins using Apple's search in iClouds
Mail.

------
frik
GMail always had a memory leak problem. Back in the early days of GMail
(2004-2005), Internet Explorer 6


New York (Paul A. Crotty, District Judge), granting summary judgment to then-Defendants-Appellees Michael Chertoff, former Secretary of the Department of Homeland Security ("DHS"), and Condoleeza Rice, former Secretary of State, sued in their official capacities. The organizations alleged that the denial of a visa to Tariq Ramadan, an Islamic scholar, violated their First Amendment right to have Ramadan share his views with the organizations and with the public in this country. The Supreme Court has recognized a First Amendment right to "hear, speak, and debate with" a visa applicant. See Kleindienst v. Mandel, 408 U.S. 753, 92 S.Ct. 2576, 33 L.Ed.2d 683 (1972). Ramadan is also a Plaintiff-Appellant, but because he has no constitutional right to a visa, see id. at 762, 92 S.Ct. 2576, he is what8 U.S.C. § 1187(a)(9) (2006).
On September 16, 2005, Ramadan applied for a B visa to enter the United States for a short period of time to attend conferences, including events sponsored by Plaintiffs-Appellants AAR and AAUP. See Affidavit of Tariq Ramadan ¶ 28 (Mar. 10, 2006) ("Ramadan Aff. I"). [A 51] According to Ramadan, he was interviewed by consular and DHS officials at the United States embassy in Bern, Switzerland, on December 20, 2005. See id. ¶ 30. Defendants have submitted an affidavit from the official then serving as Consul in Bern stating that Ramadan was also interviewed in September 2005. See Declaration of John O. Kinder, ¶ 10 (May 22, 2007) ("Kinder Decl."). [A808-09] He was questioned about his political views and associations. See Ramadan Aff. I


1182(a)(3)(B)(i)(VII), originally cited by a DHS spokesperson as a basis for denial of Ramadan's visa, had been disavowed by the Government as a ground for the denial. See id. at *4. The Court then noted that "the doctrine of consular nonreviewability" precludes federal courts from exercising jurisdiction to consider an alien's challenge to a denial of a visa application. See id. at *5-*7 (citing, e.g., Wan Shih Hsieh v. Kiley, 569 F.2d 1179, 1181 (2d Cir.1978); Rivera de Gomez v. Kissinger, 534 F.2d 518, 519 (2d Cir. 1976); Burrafato v. U.S. Dep't of State, 523 F.2d 554, 556 (2d Cir.1975)).
The Court then discussed the Supreme Court's decision in Mandel, which recognized that United States citizens could invoke federal court jurisdiction to challenge a visa denial on the groundII, 2007 WL 4527504, at *11. The second was whether Ramadan satisfied the knowledge requirement of the material support provision. See id.
With respect to retroactivity, the Court made the legal conclusion that the "material *122 support" provision applied to support given before the enactment of the amendment expanding the definition of an undesignated terrorist organization to include an organization that funded a terrorist organization. See id. at *11-*12. With respect to Ramadan's knowledge, the Court interpreted the material support provision to require the Government to show only that Ramadan knew he was giving money to ASP, and then placed on Ramadan the burden of satisfying the "unless" clause of the provision. See id. at *12-*14. The "unless" clause states that a visa applicant is ineligible under the material


support provision "unless [he] can show by clear and convincing evidence that [he] did not know, and reasonably should not have known, that the organization [to which he provided funds] was a terrorist organization." § 1182(a)(3)(B)(iv)(VI)(dd).
With this understanding of the statutory knowledge requirement, the Court then appeared to make its own factual findings as to Ramadan's knowledge, rather than confine its inquiry to the adequacy of the findings reflected in the affidavit of the consular officer who informed Ramadan of the visa denial. The Court readily found that Ramadan knew he was giving money to ASP from his admission of this fact. American Academy II, 2007 WL 4527504, at *13. With respect to the "unless" clause, the Court considered three items of evidence tendered by Ramadan to theabsence of an allegation that the consular officer "did not in good faith believe the information he had." Id.
In Adams, the visa was denied pursuant to 8 U.S.C. § 1182(a)(28)(F) (1988) (repealed), which rendered inadmissible aliens "who advocate or teach" various forms of terrorism. See Adams, 909 F.2d at 646. The consular officer determined that Adams fit within that category `because of his advocacy of, and personal involvement with, IRA terrorist violence, including participation in bombings.' See id. The First Circuit ruled that the statutory ground and the alien's conduct together provided the "facially legitimate and bona fide" reason for the visa denial.
In Abourezk II, the visas were denied pursuant to 8 U.S.C. § 1182(a)(27) (1982) (repealed), which rendered inadmissible aliens who "seek to enter the United States


terrorist organization... described in clause (vi)(III) ... unless the actor can demonstrate by clear and convincing evidence that the actor did not know, and should not reasonably have known, that the organization was a terrorist organization." Clause (vi)(III) defines "terrorist organization" to mean "a group... which engages in ... the activities described in subclauses (I) through (VI) of clause (iv)," which include funding a terrorist organization. Three issues arise as to whether the consular officer properly construed and applied these statutory provisions *127 to Ramadan. These issues concern (A) retroactivity, (B) the knowledge requirement, and (C) the "unless" clause.
(A) Retroactivity. The first issue concerns retroactivity. The Government acknowledges that, prior to enactment of the REAL ID Act in 2005, the "material support" provision of the INA did notterrorist nature of the recipient of material support would lead to the odd reading of subclause (VI)(bb) whereby there would be first a requirement that the alien knew he was rendering material support and then two requirements that the alien knew that the individual recipient was engaged in terrorist activity.
We are mindful of the Supreme Court's recent decision in Flores-Figueroa v. United States, ___ U.S. ___, 129 S.Ct. 1886, 173 L.Ed.2d 853 (2009), which interpreted the knowledge requirement of 18 *131 U.S.C. § 1028A(a)(1). That provision requires a mandatory consecutive two-year sentence if, during the commission of other crimes, the defendant "knowingly transfers, possesses, or uses, without lawful authority, a means of identification of another person." The Court ruled that the knowledge requirement applied to all elements of


to the facts appearing in the administrative record, see id. at 17, and rejected the aliens' claim to an evidentiary hearing in the District Court, see id. at 16-17.
The Ninth Circuit's decision in Nadarajah v. Gonzales, 443 F.3d 1069 (9th Cir. 2006), also cited by the Appellants, is less helpful. First, the Court stated that if "a facially legitimate and bona fide reason" is given for a denial of parole pending immigration proceedings, "the denial of parole is essentially unreviewable." Id. at 1082. Second, in granting parole, the Court ruled that continued detention after five years was unlawful and that the evidence favoring release was undisputed. See id. at 1083.
We doubt that the judicial decisions reviewing administrative denial of parole are even applicable to consular denial of aa tiny bit of real estate.

For my money I'm not convinced that the offline analogy really adds to it. You
know your market better than me (or anyone else here except Pete and Dan) but
I feel like you could jump straight in with a story about an online store.

"Mike sells bikes online but he's not sure which ones to put on the front
page. Will he get the most sales from showing someone bikes on the frontpage
or showing them chainsets? He doesn't know and he finds it hard to read his
analytics to figure out which one is best. VisualWebsiteOptimiser does all
this for him..."

~~~
speeder
Beside the stupidity of selling fish online...

You CAN do A/B testing of sorts on the physical store too. This might break
the attention of people that know that.

I guess


the intention were good, and the drawings are of good quality, but
otherwise the execution is just terrible.

~~~
CGamesPlay
Agree with this. When I saw "no solution" it immediately removed the faith I
had in the site's ability to follow the scientific method.

------
mtrimpe
Really love the animation, but I can't help but wonder if A/B testing couldn't
be explained more powerfully.

Within the example of the store for example, the real pain A/B testing
addresses is cyclical variation leading to incorrect conclusions.

Working from that you could've shown the story of:

* the store owner rearranging his display and seeing sales go up

* but then the rest of the year sales actually going _way_ down

* and when he changes things back to the _old_ layout sales went _waaay_ up again! How can that be?

* Cue image of cyclicalblog post [2] on how I made it in detail soon.

[1]
[https://github.com/Prinzhorn/skrollr](https://github.com/Prinzhorn/skrollr)
[2] [http://kushagra.me/blog/](http://kushagra.me/blog/)

~~~
nbouscal
One problem for you to be aware of: something about the scroll handling breaks
the two-finger swipe Back functionality on my Macbook. It's a minor thing, but
very annoying.

------
huhtenberg
Stars of David coming out of the "A/B-Testing" explosion - I bet it's some
sort of clever innuendo, but it just seems to escape me :)

~~~
goatcurious
Certainly not a clever innuendo. Looks more like an oversight. There isn't
much awareness about Star of David in India.

It is the easiest star to sketch -- even my teacher in elementary school used
to use the same star in my grading.

~~~
paraschopra
Hmm. We weren't (and aren't) aware of Star of David.

~~~
winter_blue
FYI it's the flag of Israel...

------
zachlatta
Very neat. Hate the loading screen though. Having to display a loading screen
is almost


want to be sure, they should wait for 99% significance.

~~~
Ovid
_As soon as significance is achieved, we show a "winner"_

If you've described that accurately, you're hurting some of your customers.
It's not well-known (though it should be obvious, in retrospect), but a test
can produce a false positive when, in fact, it's a negative.

The problem is that there is always noise in customer data and sometimes
you'll randomly have enough conversions such that one of your tests will show
a winner when it's not.

Matts Einersen has some simulation code to show this:
[http://www.einarsen.no/is-your-ab-testing-effort-just-
chasin...](http://www.einarsen.no/is-your-ab-testing-effort-just-chasing-
statistical-ghosts/)

Evan Miller has a more in-depth (but harder to follow) discussion here:
[http://www.evanmiller.org/how-not-to-run-an-ab-
test.html](http://www.evanmiller.org/how-not-to-run-an-ab-test.html)

If, in fact, you show the winner as soon as significance is achieved, it's
then trivial to demonstrate that some of your customers will lose money as a
result. However, if you takeand will hereinafter be called interfering currents. This problem is encountered particularly in the firing region of the thyristor. If this region is designed to be sensitive to firing at a low excitation density by suitable geometric dimensions and doping, undesired firing will occur already at low values of interfering currents.


major purchases and how vigilant you were in paying them. Some drivers might worry their credit history will bar them from a particular car purchase, but with the right team, you shouldn’t have to worry too much.

The bigger your down payment is, the lower your monthly payments will be. And even if you have some cash already put away for this, you can maximize it by putting your current car’s trade-in down on top of things.

Sit Down with the Finance Team and Talk

Working with a dealership’s finance team has a huge benefit: You automatically have someone in your corner. And they’ve got enough skills to find a solution for you.

If you need any more advice, don’t hesitate to sit down with them and chat. They’re here to help,Dietitians Email List

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hip screw placed initially. High tip apex distance was found to be associated with the revision (p<0.0001).Demographic parameters and co-morbid conditions were not associated with a need for revision surgery (p>0.05). Patients requiring dynamic hip screw implant revision had higher tip apex distance than the rest. A lower value is advisable during placement of the screw to reduce the need for subsequent revision.Photoresists are photosensitive films for transfer of images to a substrate. They form negative or positive images. After coating a photoresist on a substrate, the coating is exposed through a patterned photomask to a source of activating energy, such as ultraviolet light, to form a latent image in the photoresist coating. The photomask has areas opaque and transparent to activating radiation that define an image desired to be transferred to the underlying substrate.
Chemical amplification-type photoresists have proven to be useful in achieving high sensitivity in processes for forming ultrafine patterns in the manufacture of semiconductors. These photoresists are prepared by blending a PAG with a polymer matrix having acid labile structures. According to the reaction mechanism of such a photoresist, the photoacid generator generates acid when it is


   if ($role -eq 1)
    {
        $teamrepourl = 'https://'+$server+'.visualstudio.com/_git/'+$teamreponame
    } ElseIf ($role -eq 2)
    {
        $teamrepourl = 'https://'+$server+'.visualstudio.com/'+$generalreponame+'/_git/'+$teamreponame
    } else{
        $generalrepourl = 'https://'+$server+'.visualstudio.com/'+$generalreponame+'/_git/'+$teamreponame
    }
    if ($role -lt 3)
    {
        Write-host "URL of the "$name1 "is "$generalrepourl -ForegroundColor "Yellow"
        Write-host "URL of the "$name2 "is "$teamrepourl -ForegroundColor "Yellow"
    } else{
        Write-host "URL of the "$name1 "is "$generalrepourl -ForegroundColor "Yellow"

                    } else{ #storage account does not exit
                        Write-Host "Storage account" $sa "will be created..." -ForegroundColor Yellow
                        Write-Host "You need to select the resource group name under which the storage account will be created." -ForegroundColor Yellow


       Write-Host "Here is the list of existing resource group names" -ForegroundColor Yellow
                        echo $resourcegroupnames
                        $rg0 = Read-Host 'Enter the resource group name (New or existing names are OK. Only alphanumeric, underscore, and hyphen are accepted)'
                        $rg = $rg0 -Replace '[^a-zA-Z0-9-_]' #enforce the naming convention
                     $havegoodsaname = $true
                        $index = [array]::indexof($resourcegroupnames,$rg)
                        if ($index -ge 0){ #resource group already exists
                            Write-Host "Start creating storage account "$sa "under resource group "$rg "at "$loc -ForegroundColor Yellow


   while (!$goodsaname -and !$quitornot)
        {
            $sa = Read-Host "Enter the storage account name where the Azure file share you want to mount is created"
            $index = [array]::indexof($storageaccountnames,$sa)
            if ($index -ge 0){
                $rg = $resourcegroupnames[$index]
                $goodsaname = $true
            } else{
     in them." -Ephesians 2:8-10

"Yea doubtless, and I count all things but loss for the excellency of the knowledge of Christ Jesus my Lord: for whom I have suffered the loss of all things, and do count them but dung, that I may win Christ, And be found in him, not having mine own righteousness, which is of the law, but that which is through the faith of Christ, the righteousness which is of God by faith." -Philippians 3:8-9


Make sure to get your hands on this 2016 Dodge Charger SXT with a push button start, backup camera, a navigation system, a leather interior, dual climate control, heated seats, traction control, and side air bag system before it's too late! It comes with a 6 Cylinder engine. This One's on the market for $25,971. Don't skimp on safety. Rest easy with a 5 out of 5 star crash test rating. Complete with a ravishing gray exterior and a black interior, this vehicle is in high demand. Work on your tan while sitting in traffic...just open the sunroof! No more maps! Just use the navigation system. The Black leather interior combines durability and elegance. Don't waste a moment with push button start. Designed to support the back, power10. Let b be q(13). Calculate the highest common divisor of b and 24.
24
Let c(a) = -54*a + 4. Let o be c(-3). Let z = o - 58. Calculate the greatest common divisor of z and 27.
27
Suppose 18*l - 14*l = 168. Suppose -l = -k - 5*k. Suppose -2*g + 77 = -g. What is the highest common factor of g and k?
7
Let q(p) = -3*p**3 - 4*p**2 + 10*p + 4. Let d be q(-4). What is the highest common divisor of d and 207?
23
Suppose 3*n + 10 = 64. Let q be (n + 0)*(-6 + (-87)/(-9)). Calculate the highest common factor of 44 and q.
22
Suppose -2*c + 0*c + 20 = 0. Suppose -7*g + 20 = -2*g. Suppose 5*j = 3*j +


Calculate the greatest common factor of i and 392.
8
Suppose 158 = 5*z - 2*o, 2*z + z - 3*o = 102. Calculate the highest common divisor of z and 12.
6
Let i = 41 - 38. Suppose i*x = 6*k - 8*k + 182, -5*k - x = -429. What is the highest common factor of 34 and k?
17
Let h be 161 - 1 - (3 - 0). Suppose -5*x = 5*i - 385, -5*x - i = -3*x - h. Let t be 8/(-3)*15/(-4). Calculate the greatest common divisor of x and t.
10
Let k = -25 + 26. Let b be k*(15 - 2)*1. Calculate the highest common factor of 143 and b.
13
Let v(o) = -8*o + 50. Let r be v(7). Let z be -2 + (-588)/(-72)& y^{-1}
\end{pmatrix},0\right).$$We use the fact that, for every $0<v_0< v_1$, the set $$\Gamma \backslash \Gamma \left\{ (1,\xi)n_+(u)a(v): v_0<v<v_1, (u,\xi)\in \mathbb{H}\left( \mathbb{R} \right) \right\}$$is an embedding of $(v_0,v_1) \times \mathbb{H}\left(\mathbb{Z}\right)\backslash \mathbb{H}\left(\mathbb{R}\right)$ as a submanifold of $ \Gamma \backslash G $. By thickening this submanifold, we can use Strömbergsson’s result to obtain equidistribution of our points.

As for the pointwise limit of the pair correlation measure $R_{2,N}$, we show in Appendix \[sec:Equidistribution-on-Heisenberg\] that it also converges to the Lebesgue measure (and is thus consistent with the Poisson distribution), under the following equidistribution conjecture on the Heisenberg group $\mathbb{H}\left(\mathbb{Z}\right)\backslash\mathbb{H}\left(\mathbb{R}\right)$, which is a pointwise version of Proposition \[prop:equi\_prop\] in the special case $ \eta = (1/2, \alpha) $:

For $f\in C^{k}\left(\mathbb{H}\left(\mathbb{Z}\right)\backslash\mathbb{H}\left(\mathbb{R}\right)\right),$ define the norm $$\left\Vert f\right\Vert _{C^{k}}=\sum_{\operatorname{ord}D\le k}\left\Vert Df\right\Vert _{\infty}$$ summing over all monomials


& = & \frac{u}{v}\frac{\partial}{\partial\xi_{1}}+\frac{1}{v}\frac{\partial}{\partial\xi_{2}},\end{aligned}$$ and therefore (Since $ \omega $ and $ \epsilon $ are fixed) $\left\Vert F\right\Vert _{C_{b}^{8}} \ll \left\Vert f\right\Vert _{C^{8}}$. Note that equation (\[eq:EquiFarey\]) also holds with $ \nu\left( \frac{d}{c}\right) $ on the l.h.s. instead of $ \nu\left(- \frac{d}{c}\right) $, since we can replace the function $ \nu(x) $ with $ \nu(-x) $, leaving the r.h.s. of (\[eq:EquiFarey\]) unchanged. Hence, the statement of the proposition follows.

Proof of Proposition \[prop:KeyProp\] {#sec:Prop2.2Proof}
-------------------------------------

By the invariance of $\left|\Theta_{h}\right|^2$ under $\tilde{\Gamma}$ and since for any $ \begin{pmatrix}
a & b\\
c & d
\end{pmatrix} \in \Gamma' $ we have $ ab/2 \equiv (a+b-1)/2 \mod 1$, we see that the function $$F(x+iy,\phi,\xi) = \left|\Theta_{h}\left(x+iy,\phi,\begin{pmatrix}
\xi_{1}-\frac{1}{2}\\
\xi_{2}-\frac{1}{2}
\end{pmatrix}\right)\right|^{2}$$ belongs to $ C^\infty(\Gamma \backslash G) $, i.e., for every $ \left(\begin{pmatrix}
a & b\\
c & d
\end{pmatrix},m\right)\in \Gamma$, we have $$F(\tau,$\left\Vert f_{\sigma^{2},\frac{\pi}{2}}\right\Vert _{C^{k}}\ll \left\Vert h\right\Vert _{C^{n}}^2\sigma^{k+1}.$ Thus we conclude that (\[eq:equidistLimit\]) is equal to $$\hat{\nu}\left(0\right)\left\Vert h\right\Vert _{2}^{2}+O\left(L\left\Vert h\right\Vert _{C^n}^2 \left\Vert \nu\right\Vert _{C^{l}}\left(N^{-\delta+\epsilon}+N^{-t+\delta\left(k+t\right)+\epsilon}\right)\right)$$ and taking $\delta>0$ sufficiently small, Proposition \[prop:ConjecturedProp\] follows.

[1]{}

M. V. Berry and M. Tabor, *Level clustering in the regular spectrum*. Proc. Roy. Soc. A. **356** (1977), 375394.

P. M. Bleher, *The energy level spacing for two harmonic oscillators with generic ratio of frequencies*. J. Statist. Phys. **63** (1991), no. 1-2, 261283.

F. P. Boca and A. Zaharescu, *Pair correlation of values of rational functions (mod $ p $)*. Duke Math. J. **105** (2000), no. 2, 267307.

S. De Bièvre, M. Degli Esposti and R. Giachetti, *Quantization of a class of piecewise affine transformations on the torus*. Comm. Math. Phys. **176** (1996), no. 1, 7394.

F. Cellarosi and J. Marklof, *Quadratic Weyl


replications of each experiment is shown in parentheses for each group in the bar graphs. See [Source data 1](#sdata1){ref-type="supplementary-material"} for values used in statistical analyses. [Figure 1---figure supplement 1](#fig1s1){ref-type="fig"} shows that Sig-1R knockdown alters cocaine effects on EV release as well as the identification of the ARF6 binding site in NG108 cells.](elife-47209-fig1){#fig1}

Cytohesins are a family of GEFs that activate ARFs by catalyzing a shift from GDP- to GTP-bound forms ([@bib7]; [@bib12]; [@bib18]), and this can trigger EV release from LOX cells ([@bib7]; [@bib63]). To determine whether ARF6 is similarly involved in cocaine-induced release of EVs in NG108 cells, we used the GEF inhibitor secinH3 (SH3, 10 µM) ([@bib18]) and found that it prevented the cocaine-stimulated increase in Iβ1 levels in the EV fractions ([Figure 1E](#fig1){ref-type="fig"}). To next determine themarkers ([Figure 2G](#fig2){ref-type="fig"}) in midbrain preparations from mice lacking the Sig-1R gene (*Sigmar1*), suggesting that Sig-1Rs are essential for cocaine-induced tEV release in mouse midbrain.

The Sig-1R associates with the inactive form of ARF6 in mouse midbrain {#s2-3}
----------------------------------------------------------------------

To determine cellular locations of the Sig-1R we used immunofluorescence confocal microscopy in the mouse ventral midbrain. We found that Sig-1R ([@bib40]) and TH fluorescence signals were colocalized ([Figure 3A](#fig3){ref-type="fig"}), and as TH is a marker for DA neurons in the ventral midbrain, the data suggest that Sig-1Rs are found in DA neurons. However, the Sig-1R signal was also found associated with the vesicular GABA transporter (vGAT), a marker of GABA neurons in the mouse ventral midbrain ([Figure 3A](#fig3){ref-type="fig"}). Therefore, the Sig-1R is likely expressed in both DA and GABA neurons in the


antagonism, or by genetic deletion of this receptor ([Figure 6---figure supplement 1](#fig6s1){ref-type="fig"}). This indicates that Sig-1Rs are linked to cocaine-stimulated 2-AG function in the CNS, and that CB1R signaling is not diminished by altered Sig-1R function or expression.

![Inhibition of IPSCs by cocaine in VTA DA neurons depends upon Sig-1Rs.\
(**A**) Mean waveforms showing the effect of cocaine (10 µM) on GABA~B~ IPSCs in a DA neuron from a wildtype mouse during application of the Sig-1R antagonist NE100 (2 µM, left), or in a cell from a Sig-1R KO mouse (right). (**B**) Mean time-course showing effect of cocaine on IPSCs in absence (Control) and presence of NE100 in wildtype mice. (**C**) Mean time-course showing effect of cocaine on IPSCs in absence (Control) and presence of BD1063 (2 µM) in wildtype mice.previous report ([@bib68]), co-application of the α~1~R agonist phenylephrine (PE, 100 µM) and the mGluRI agonist, DHPG (1 µM) inhibited GABA~B~ IPSCs in wildtype mouse VTA DA neurons, and this was blocked by AM251 ([Figure 7B and C](#fig7){ref-type="fig"}). However, it is also important to note that the properties of the IPSC inhibition produced by DHPG+PE differed from that seen with cocaine. Thus, the response to DHPG+PE was much slower to reach maximum and lacked the early fast component observed with cocaine ([Figure 7---figure supplement 1](#fig7s1){ref-type="fig"}) in wildtype mice. Therefore, in comparison, the effect of DHPG+PE primarily consisted of the delayed slow component ([Figure 7---figure supplement 1C](#fig7s1){ref-type="fig"}). Also, in DA neurons from Sig-1R knockout mice, the slow response to DHPG+PE was significantly smaller ([Figure 7A--7C](#fig7){ref-type="fig"}, [Figure 7---figure supplement 1A](#fig7s1){ref-type="fig"}),


cases, brain tissue from each mouse was used in both control and treatment conditions. NG-108 cell culture dishes were selected randomly from those available in the tissue incubator.

Isolation of mouse midbrain slices {#s4-4}
----------------------------------

Mice were killed with CO~2~ gas, and brains were removed, and rinsed in ice-cold Hank's balanced salt solution (Thermo Fisher Scientific). Midbrain samples were isolated by cutting coronal sections containing the VTA using mouse brain matrices (Roboz), and the cortex and a hippocampus dissected free ([Figure 2---figure supplement 1](#fig2s1){ref-type="fig"}).

Preparation of EV fractions {#s4-5}
---------------------------

### NG108 cells {#s4-5-1}

To isolate EVs from NG108 cells we used an established protocol with minor modifications ([@bib15]). First, conditioned HBSS was collected and pre-cleared from cells and debris by centrifugation at 300 x g for 10 min, and 2000 x g for 10the cocaine stimulated 2-AG increase is specific for EVs and not general for all midbrain membranes must be provided (see verbatims of the reviewer\'s comments below). The editors and reviewers during their discussion were in full agreement on these essential revisions.

Reviewer \#1:

In this interesting and provocative study, Nakamura and colleagues examine the hypothesis that cocaine stimulates 2-AG secretion through its interactions with the sigma-1 receptor (Sig-1R) leading to release of EVs (enriched) in 2-AG, which then engage CB1 receptors.

1\) Central to their hypothesis is that cocaine causes release of EVs containing 2-AG. To demonstrate release, it is necessary to isolate them from the media of the NG108-15 cells (as was done in the Gabrielli study). From a careful reading of the Materials and methods, it does not seem


7), the emphasis of cocaine binding to Sig-1R as a causal mechanism in mid-brain eCB IPSC inhibition appears misplaced. If anything, in the cocaine treated slices, Sig-1R is only necessary for the short term (\<20 minutes) cocaine/eCB-mediated depression of IPSCs (Figure 6D) as IPSC inhibition by cocaine seems similar in the wildtype and Sig-1R KOs by 30 minutes (Figure 6D). In contrast (Figure 7B), for phenylephrine/DHPG 2-AG-mediated IPSC inhibition, Sig-1R KO reduces IPSC inhibition over the entire 30 minutes of drug application. An alternative to the mechanism proposed in the Discussion (cocaine binds to the Sig-1R..., and Figure 8---figure supplement 1) is that cocaine increases NE, activating α~1~Rs, which then require Sig-1R, ARF6, etc., to release EVs (or stimulate DAGLA activity). The experimental data in midbrain slices thathigh degree of variability in both baseline levels of 2-AG using FTMS, and in the level of the cocaine-induced increase in 2-AG levels. In general, there is a trend toward increased 2-AG in fr3 in the cocaine-injected mice (see [Author response image 1](#respfig1){ref-type="fig"}), but this does not reach statistical significance because of the high degree of variability across cohorts. It is likely that some of this variability results from the difficulty of the dissection procedure (identifying and dissecting only ventral midbrain from a whole a mouse brain) and to other factors that we have not yet identified. Therefore, at present we are confident that we can identify 2-AG in the EV-containing fr3 from mouse midbrain, but we do not have the statistical power to demonstrate a significant increase


(New East Biosciences, Malvern, PA, catalog number 26918) indicates that it can distinguish ARF6-GTP from ARF6-GDP. However, as we are unable to use this antibody for quantitative Western blot analyses of ARF6-GTP, and we have confirmed co-localization of ARF6 with TH and the Sig-1R in the mouse midbrain in Figure 3, we have elected to remove this image (Figure 4D) and descriptions of measurement of ARF6-GTP from the manuscript.

> Reviewer \#3:
>
> \[...\] 1) Figure 1---figure supplement 1A and B. The authors should provide the fold change in expression of Sig-1R to help the reader better understand the impact of this result.

We agree with the reviewer that this information is important to include, and we have added it to the Figure 1---figure supplement 1A caption. The siRNA significantly reducedAn alternative to the mechanism proposed in the Discussion (cocaine binds to the Sig-1R..., and Figure 8---figure supplement 1) is that cocaine increases NE, activating α~1~Rs, which then require Sig-1R, ARF6, etc., to release EVs (or stimulate DAGLA activity). The experimental data in midbrain slices that cocaine needs to bind to sig1-Rs for IPSC inhibition does not seem conclusive, only that Sig-1R and ARF6 are required at some point in the pathway.

In re-considering these data, we noted differences between the inhibition of IPSCs produced by DHPG+PE and cocaine that we feel might explain this and we have included this in the manuscript in the form of new information in the Results and Discussion, and a new Figure 7---figure supplement 1. Specifically, we noted that the kinetics of the


the other hand, at least Sig-1Rs are required for both early and late IPSC inhibition by phenylephrine/DHPG. Can the authors integrate these findings into their model?

See response to part "a" above.

> 3\) Figure 5C: The WB results showing FLOT-1 in EV has a \"dark dot\" in its lane which limits the interpretation of the result. The authors should provide another representative result.

This has been remedied by providing another WB from another similar experiment.

[^1]: Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.

[^2]: These authors contributed equally to this work.
and show that the company can still innovate in the post-Steve Jobs era. That's the only way to get revenue and earnings estimates moving higher again.

The iPhone 5S or iPhone 6 might not be enough to convince anyone other than the Apple sycophants that the company is still on the cutting edge of technology. Neither would newer iPads, an iWatch or some sort of rumored online radio service. It might take the launch of the mythical (for now at least) iTV to do that.

But Apple investors can take solace in the fact that being down does not mean you are out as long as you can reinvent yourself. Just ask Google. That stock had an even bigger fall from grace than Apple a few years ago.

Google lost more


than two-thirds of its value in a year, tumbling from a then all-time high of $747 in November 2007 to a low of $247.30 12 months later. Those were unique circumstances, obviously, given that it happened during the start of the Great Recession and the worst of the credit crisis that paralyzed the entire stock market.

But there were many investors in 2008 and early 2009 who probably felt that Google's best days were behind it. It was considered a one-trick pony. Flash forward four years, and that's clearly not the case. The stock hit a new all-time high this month of $844. That's because Google has successfully branched into new markets beyond its bread-and-butter business of search, most notably display ads through video site YouTube and of course,impairments. Individuals with T2D show lower resting blood flow in the brain and a reduced ability to maintain stable and sufficient cerebral blood flow (CBF) compared to controls.^[@bibr21-0271678X17746186],[@bibr22-0271678X17746186]^ The microvasculature within peripheral tissues is particularly sensitive to insulin, and this sensitivity is impaired by obesity and IR.^[@bibr23-0271678X17746186]^ Insulin has many important actions in the brain, and brain IR has been proposed to contribute to the progression of AD.^[@bibr24-0271678X17746186]^ Furthermore, administration of intranasal insulin results in enhanced cognition in T2D patients that is related to regional vasoreactivity.^[@bibr22-0271678X17746186]^

Reduced CBF is seen in elderly E4 carriers relative to non-carriers in multiple brain regions.^[@bibr25-0271678X17746186]^ Cognitively, normal E4 individuals also show accelerated declines in regional CBF during aging,^[@bibr26-0271678X17746186]^ and the association between cognitive function and age-related changes in CBF is modified by *APOE*


were injected following a 4-h fast with 0.75 μCi of 2-\[1,2-^3^H (N)\]-deoxy-d-glucose (Perkin Elmer) diluted in glucose solution (2 mg/d body weight) via the tail vein. For glucose uptake during the water maze test (see below), mice were administered an oral gavage (8 μl/g body weight) of 2-\[1,2-^3^H (N)\]-deoxy-d-glucose (0.06 μCi/g body weight) diluted in glucose solution (2 mg/g body weight) 14 min prior to a 1-min long memory trial (see Cognitive Testing for details). Tissue glucose uptake was adjusted to plasma values to adjust for variations in injection volumes and dietary absorption. Fifteen minutes after injection or gavage, mice were intraperitoneally administered a lethal dose of ketamine--xylazine--acepromazine cocktail (0.01 ml/g of 25 mg/ml ketamine (Sigma), 0.625 mg/ml acepromazine (Vetus Animal Health), 3.125 mg/ml xylazine (Sigma)). To flush out remaining blood, mice were intracardially perfused with 20 ml ofboth E3 and E4 mice, E4 HFD mice gained less weight and less adipose tissue than E3 HFD mice ([Figure 1(a)](#fig1-0271678X17746186){ref-type="fig"} and ([b](#fig1-0271678X17746186){ref-type="fig"})). HFD also led to elevated fasting plasma glucose concentrations and deficits in glucose tolerance and insulin sensitivity, with a similar degree of impairment observed in E3 and E4 HFD mice ([Figure 1(c)](#fig1-0271678X17746186){ref-type="fig"} to ([e](#fig1-0271678X17746186){ref-type="fig"})). LFD-fed E3 and E4 mice did not differ in any of the measured markers of peripheral metabolism ([Figure 1(a)](#fig1-0271678X17746186){ref-type="fig"} to ([e](#fig1-0271678X17746186){ref-type="fig"})). Figure 1.E4 HFD mice gain less weight than E3 HFD mice but show similar degree of insulin resistance. (a) E4 mice gain less weight when fed an HFD than E3 mice fed an HFD. *n* = 5--9. (b) E4 HFD mice accumulate less visceral adipose tissue than E3 HFD mice following six


glucose were associated with an increase in tissue glucose uptake. To answer this, mice were administered radiolabeled 2-deoxyglucose (2DG) at rest, or prior to a memory test, and glucose uptake in the two primary organs expected to be activated during the water maze -- brain and skeletal muscle -- was assessed. While there was no significant effect of *APOE* or diet on resting glucose uptake in skeletal muscle, E4 was associated with reduced brain glucose uptake at rest (*p* = 0.0274, two-way ANOVA) ([Figure 5(a)](#fig5-0271678X17746186){ref-type="fig"} and ([b](#fig5-0271678X17746186){ref-type="fig"})). To determine glucose uptake during a cognitive challenge, mice were given an oral gavage of ^3^H-2DG 14 min prior to a water maze probe and tissue uptake was assessed immediately following the 1-min long memory test. Glucose uptake during the cognitive challenge was significantlyJapan and went on to study in the Cranbrook Academy of Art in Michigan, where she received her masters of fine arts degree.
After graduating, MacAdam worked for Boris Kroll Fabrics, an acclaimed textile design company in New York City. She then went on to teach at universities across the United States and Japan, including the Columbia University Teachers College, Haystack Mountain School of Crafts, the University of Georgia and the Kyoto Junior College of Art.

Currently, MacAdam teaches a textiles and fashion course entitled "Fiber Fabric Fashion" at NSCAD University in Halifax, Nova Scotia and runs Interplay Design and Manufacturing with her husband, Charles MacAdam, in Bridgetown, Nova Scotia.

Work

Early work

MacAdam’s work is often described as 'fibre art' which became a widely accepted art form in the 1970s. 'Fibre


Laurence Llewelyn-Bowen puts his 16th-century country pile on the market

Laurence Llewelyn-Bowen is ready for a London-move after putting his £1.75 million family home in Gloucestershire on the market

Laurence Llewelyn-Bowen is keen to move to London and is said to have put the family home, a 16th-century Gloucestershire country mansion, up for sale at £1.75 million.

The interiors guru and television personality, 48, and his wife Jackie, pictured, have lived in the Grade II-listed house seven years with their two daughters. But the couple, who appeared on ITV’s dance show Stepping Out last year, are said to fancy a complete change.

They might consider a house swap with film star couple Sienna Miller and Tom Sturridge, who recently put their home in north-west London on the market for £3 million, andX-ray inspection systems have generally been used to inspect the contents of automobiles, trucks, rail cars, cargo containers, and other vessels of transport. Such systems are generally set up at airports, seaports, building entrances, border crossings, and other places where contraband; weapons, explosives, drugs, or other illegal items are likely to be found in transit. X-ray inspection systems are also often used to verify the contents of containers and vehicles, and to ensure the accuracy of shipping manifests and the like.
X-ray inspection systems for inspecting large objects are generally of the “fixed-site” variety, wherein vehicles or containers are brought to the inspection site to undergo X-ray imaging. Such systems commonly comprise a large inspection tunnel through which vehicles or containers are transported. The vehicles or containers are generally


Toll-like receptor 4 signaling. In lipopolysaccharide (LPS)-treated DCs, SD inhibited the expression of cell surface molecules (MHC I/II, CD40, CD80, and CD86), the production of inflammatory mediators (nitric oxide, IL-12, IL-1β, and TNF-α), and allogenic T cell activation capacity. SD also inhibited DC migration toward MIP-3β by down-regulating CCR7 expression. SD attenuated LPS-induced activation of NF-κB and MAPK signaling in DCs, but did not directly inhibit kinase activities of IRAK1, IRAK4, TAK1, or IKKβ in enzymatic assays. SD did not inhibit LPS binding to myeloid differentiation protein-2, co-receptor of TLR4. SD increased the production of reactive oxygen species, Nrf-2, and heme oxygenase (HO)-1, which degrades the heme to immunosuppressive carbon monoxide and biliverdin, which may underlie the anti-inflammatory effects in SD-treated DCs. Taken together, these data suggest thatinvestment concepts, such as risks vs returns; simple financial ratios; passive vs active investing; and diversification. A good financial advisor will be able to explain them to you and help work out your risk profile.

Consider fees which may come with the investment as different banks/firms may charge different brokerage and transaction fees, or offer different incentives and promotions. Should you choose to invest in stocks using your SRS account contributions, you can do so through a DBS Vickers account.

Finally, know that all profits made from investing your SRS contributions will return to your SRS account.

Strike the right balance between SRS contributions and your earned income

While it is wise not to let your SRS money lay stagnant, understand that contributing to your SRS account is a regular, stretched-out process


View getView(int position, View convertView, ViewGroup parent) {

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        TextView devName= (TextView) view.findViewById(R.id.devName);
        TextView devMac= (TextView) view.findViewById(R.id.devMac);

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BluetoothDev.java
package com.example.fatma.listviewcst;

import android.bluetooth.BluetoothAdapter;
import android.bluetooth.BluetoothDevice;

import java.util.ArrayList;
import java.util.Set;

/**
 * Created by FATMA on 02/04/2016.
 */
public class BluetoothDev {

   public ArrayList<BluetoothDevice> getDevices(  BluetoothAdapter bluetoothAdapter) {
        ArrayList<BluetoothDevice> arrayListBluetooth = new ArrayList<BluetoothDevice>();

                Set<BluetoothDevice> pairedDevices = bluetoothAdapter.getBondedDevices();
// If there are paired devices
                if (pairedDevices.size() > 0) {
                    // Loop through paired devices
                    for (BluetoothDevice device : pairedDevices) {


Q:

Geometry and trigonometry Courses

I have recently finished my higher maths in Scotland which is equivalent to A-Level maths in the uk or APs in the USA (I think).
I want to concentrate fully on geometry and trigonometry so I don't think I want to do a maths degree, but I would like to concentrate solely on these subjects.
Can anyone recommend any courses online that I can use to further my knowledge?

A:

You may be able to find material that "concentrate fully on geometry and trigonometry", but I don't think it's a good idea to limit your focus so absolutely. Everything in mathematics is connected ... okay, that is too strong, but many things in mathematics are connected, and if your goal is understanding, then you shouldn't spurn other areas that/ 2.0,
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 Q:

How to compare varchar parameters in a natively compiled stored procedure?

I am migrating some tables and stored procedures to in-memory optimized tables and natively compiled stored procedures. I'm getting stuck on string comparison.

Comparison, sorting, and manipulation of character strings that do not
  use a *_BIN2 collation is not supported with natively compiled stored
  procedures.

CREATE TABLE [User].[FingerPrints]
(
    Id int NOT NULL PRIMARY KEY NONCLUSTERED HASH WITH (BUCKET_COUNT = 10000),
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    SecretKey VARCHAR(512) NOT NULL,
    BranchId int NOT NULL,
    SteadySign bit NOT NULL,
    CreatedOn datetime NOT NULL,
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) WITH (MEMORY_OPTIMIZED = ON, DURABILITY = SCHEMA_AND_DATA)
GO

CREATE PROCEDURE [User].[GetFingerPrint]
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from nearly 60 countries are registered in VALD.

VALD is a constantly evolving database. Newly published data is continuously added allowing for improved reproduction of stellar spectra. However, there are few atomic effects, which should be included for fine analysis of high resolution spectra. The most important are isotopic composition of the elements (IS) and hyperfine splitting of atomic levels (HFS). For example, a ratio of abundances \[Eu/Ba\] is an important indicator for studying chemical evolution of the Galaxy because Eu is a pure r-process element while Ba is an element of s-process. Both elements have several isotopes and significant hyperfine splitting (Fig \[profiles\]a,b). To study the ratio \[Eu/Ba\] we need to know accurate abundances \[Eu/H\] and \[Ba/H\], and these effects must be taken into account. Today VALD is ablewho refuse to bend to their demands on tax cuts, though a variety of spin-off organizations do more of the work at the state and local level. I should state at the outset that one of the first things that really impressed me about Emmett Hanger was his awareness of what Norquist was doing in Washington and in state governments.

I noted on Aug. 4, 2004, "Grover Norquist has been defending a Saudi financial supporter who has proclaimed sympathy with the cause of the terrorists."

Upon the occasion of the second Bush inaugural festitivites, in January 2005 I wrote:

Also present at that forum was Grover Norquist, the anti-tax activist who has earned a reputation as a political bruiser in Washington. Norquist emphasized the goal of enabling individual Americans to achieve


Brooks' wife claims he entered her house and violently demanded sex and coffee before planning to return Sunday to the Legislature in Carson City, Nev.

Brooks: "Me and my wife are going to be divorced. I'm beat up."

The I-Team left Brooks' apartment after his request to do so.

Brooks then shouted to the departing I-Team from his apartment, saying twice, "If the cops beat me up again, I'll shoot back."

The assemblyman then invited the I-Team back into his apartment.

"This whole situation has taken a toll on my marriage," Brooks said. "Now I can't go back home because the police came there yesterday, to my home on Turtle River and beat the s**t out of me. Hold on, I'll show you my face."

Brooks insisted the camera remain outside while he showed300 member, CFR founder, and Rothschild agent Colonel Mandel House was also President Wilson’s top political advisor. Wilson said “Mr. House is my second personality. He is my independent self. His thoughts and mine are one. If I were in his place, I would just do as he suggested.” This is a man who has also been called the Henry Kissinger of his day. In the book “The Intimate Papers of Colonel House” is a conversation recorded between Colonel House and the Foreign Secretary of England, Sir Edward Grey. Grey asked, “What will America do if the Germans sink an ocean liner with American passengers on board?” and House answered, “I believe that a flame of indignation would sweep the United States and that by itself would be


by economic despair; despair produced a willingness to accept a major expansion of government controls over the economy.” -Gary Allen, “The Rockefeller File”

During the depression Congressman Louis T. McFadden was a very outspoken voice against the Federal Reserve. Regarding the Great depression he said, “It was not accidental. It was a carefully contrived occurrence … The international bankers sought to bring about a condition of despair here so that they might emerge as rulers of us all.” In 1932 he said, “We have in this country one of the most corrupt institutions the world has ever known. I refer to the Federal Reserve Board and the Federal Reserve Banks. The Federal Reserve Board has cheated the people of the United States out of enough money to pay theMassimo Sarmi

Massimo Sarmi (born 4 August 1948 in Malcesine) is an Italian businessman. He was the chief executive officer of Poste italiane Spa from May 2002 to April 2014.

Career
Massimo Sarmi began his career as an engineer in the Italian Air Force.

In 1995 he became the managing director of the newly established TIM, a position that he left in 1998 and took the position of codirector for the parent company Telecom Italia.

In 2001 Siemens Italia appointed him CEO, a position he left in 2002 to become CEO of the Poste Italiane Group.

Since 2002 he has been a member of the Board of Administration of the Bocconi University in Milan.

In May 2009 he was elected for the second time to the board of Ipc, International Post Corporation, the association of


to the screw that was put in. He realized they were going to have to go in there and do it again and he was, of course, disappointed at it. He was in the tank when he first heard the news, but within a couple days, he would make the mature comment like, You know what coach, it could happen to anybody. I'm going to make the best of it, I'm going to rehab, I'm going to get ready to play and finish out the rest of the season strong.' He didn't just sit there and feel sorry for himself."

Richt on Shaun Chapas: "Shaun Chapas has played very well. Not good, but very well. There was an obvious time where he fell down on a route where hegoes, me and Kiante, people are focusing in on it more, and I'm getting more reps in practice and things like that."

White on his new role: "It's definitely different being the guy who kind of knows stuff and not the guy who's asking questions. But Bruce and Tripp are still helping him out, but it's kind of a group effort."

White on replacing Tripp Chandler and Bruce Figgins: "Tripp and Bruce are tremendous blockers. I'm not going to go toe-to-toe with those guys and come out with the same results, but I've held up throughout the season and preseason against our guys, and to me, they're some of the best players in America."

Blair Walsh on how his season has gone so far: "I feel like I'm getting there. This


protecting oneself one protects others.

"And how is it, bhikkhus, that by protecting others one protects oneself? By patience, harmlessness, goodwill, and sympathy. It is in such a way that by protecting others one protects oneself.- Sedaka Sutta [SN 47.19]

hgg wrote:Why did he always choose India? It would not be fair for all the other beings not been able to have such a teacher.

It'd be unfair for a college level student to blame his professor for providing "wrong information" to his 3-year-old niece by referring to little pink balls instead of exact terms like atoms or electrons..

If we posit that the the state of one's mind upon death importantly influences the place where one will be reborn, then, if one's thoughts close to death are about India (which is9.262506?
-5.5575036
66113.5 times -4.1
-271065.35
What is the product of -0.9 and 244257?
-219831.3
Multiply 6.68226 and 1031.
6889.41006
What is the product of -18.2619 and -4.8?
87.65712
Calculate 71848.32*-0.07.
-5029.3824
Product of 78753.9 and -0.1.
-7875.39
23 * 10169.065
233888.495
Multiply 104096.38 and -6.
-624578.28
What is the product of 27032224 and 0.2?
5406444.8
Multiply -0.243 and -666031.
161845.533
Calculate 0.08038129*5.
0.40190645
Calculate 8571173*0.9.
7714055.7
What is the product of 149 and 2.1289?
317.2061
Product of -60.3912 and -18.
1087.0416
Product of 55 and 38810.
2134550
Product of -0.2 and 63887861.
-12777572.2
What is -342.3 times 6604?
-2260549.2
Work out -847272 * -0.5.
423636
Product of 21 and 23932.11.
502574.31
Product of 1617 and -0.14955.
-241.82235
884676*-0.183
-161895.708
What is -4 times 0.005775662?
-0.023102648
-4 * -1558.12577
6232.50308
What is the product of 1.119 and -3.4704?
-3.8833776
Calculate -12.6995*168.
-2133.516
-23594 * -0.052
1226.888
Multiply 1.914 and -8.54.
-16.34556
Work out 14 * 17902.1.
250629.4
Work out -0.048 * 1964.
-94.272
11434 times -85
-971890
-16 times -1163169
18610704
387.391 * 3188
1235002.508
Product of -13.4 and -4.14.
55.476
What is -0.5 times -4.23309919?
2.116549595
-18.6 * 0.46174
-8.588364
Product of -39969.858 and 1.
-39969.858
What is the product of


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A:

If you're having scope issues I feel bad for you son, I've got 99 problems but this ain't one!
Steve's answers show the correct way to define class methods, methods that will be exposed on each instance. However, if you're encountering scope issues, this is probably due to the fact you're calling those methods from another context.
For example, if you're using Knockout and you bind one of those methods to a click binding, Knockout will override the scope to the current scope of the binding, NOT the scopeevery complement $T^{\prime }$ of $S$ we have $M=S\oplus T^{\prime }$. Clearly any ring in which idempotents are central (in particular commutative rings or reduced rings) has the property that $R_{R}$ is $ADS$. Moreover, if $R$ is commutative then every cyclic $R$-module is $ADS$. We note that every right quasi-continuous module (also known as $\pi$-injective module) is right $ADS$, but not conversely. However, a right ADS module which is also CS is quasi-continuous. We provide equivalent conditions for a module to be $ADS$. A module need not have an $ADS$ hull in the usual sense but we show that, under some hypotheses, every nonsingular right module possesses a right $ADS$ hull which is unique up to isomorphism. We call a right module $M$ completely $ADS$ if each of its


This implies $f[(m-f(m))r]=f(mr)-f(f(mr))=f(mr)-f(mr)=0$. Since $f$ extends $\pi $, this means that $0\neq (m-f(m))r\in Ker(\pi )=A.$ But $A$ being closed in $M$, we conclude $A=Ker(f)$, completing the proof.

(i)$\Leftrightarrow $(iii) This is Lemma \[ADS iff relative injectivity\] above.

(i)$\Leftrightarrow $(iv) Let $C$ be a complement of $A$. Then $\ker (\pi _{B}|_{C})=0$. Since $A\oplus C=(A\oplus C)\cap (A\oplus B)=((A\oplus C)\cap B)+A$, we have $\pi_{B}(C)=\pi _{B}(A\oplus C)=\pi _{B}((A\oplus C)\cap B)=(A\oplus C)\cap B$. This gives $\pi _{B}(C)=B$ when $M$ is ADS. On the other hand if $\pi
_{B}(C)=B$ then $M=A\oplus C$, hence $M$ is ADS.

(i)$\Leftrightarrow $(v) This is classical (Cf. Proposition 1.4 in [@MM]).

(i)$\Rightarrow $(vi) Consider $C$ a complement of $A$ containing $cR$. Since $M$ is ADS we have $M=A\oplus C$. Using $(v)$, this leads to $A$ being $cR$-injective.

(vi)$\Rightarrow $(i) This is clear since if $M=A\oplusself-injective. Since $R$ is right (left) nonsingular $E(R)=Q$. Suppose $R$ is not right indecomposable and let $e$ be a nontrivial idempotent. Then since $R$ is ADS $eR$ is $(1-e)R$-injective (cf. Lemma \[ADS iff relative injectivity\]). Furthermore, since $Hom((1-e)Q,eQ)\cong eQ(1-e)$, $(eQ(1-e)(1-e)R\subseteq eR$. Because $R$ is simple, $R=$ $R(1-e)R\subset Q(1-e)R$. This yields, $1\in Q(1-e)R$ . Therefore $Q=Q(1-e)R$, and so $eQ=eR$. Similarly $(1-e)Q=(1-e)R$ hence $R=Q$, i.e. $R$ is a right self-injective regular ring.

A simple regular right continuous ring is right self-injective.

ADS HULLS
=========

We now proceed to construct an $ADS$ hull of a nonsingular module. Burgess and Raphael (cf. [@BR]) claimed that an example can be constructed of a finite dimensional module over a finite dimensional algebra which has no $ADS$ hull. We show that, under some circumstances, such an ADS hull does exist.

Suppose


of ADS submodules $N$ such that $M<N<E(M)$. Then $\overline{M}=\bigcap_{N\in \Omega }N$. We claim that $\overline{M}$ is ADS. Clearly $E(\overline{M})=E(M)$. Let $e=e^2\in End_R(M),f^2=f\in End(E(M))$ such that $e(\overline{M})\subseteq \overline{M}$ and $f(E(M))=e^*(E(M))$. Since $M$ is nonsingular and $e(\overline{M})\subseteq \overline{M}$, we have $e(N)\subseteq N$ for every $N\in \Omega $. So, for every $N\in \Omega $, $f(N)\subset N$ because $N$ is ADS. Let $x\in \overline{M}$. Then $x\in N$ for every $N\in \Omega $. Hence $f(x)\in N$ for every $N\in \Omega $. Therefore $f(x)\in \bigcap_{N\in \Omega }N=\overline{M}$, that is $f(\overline{M})\subseteq \overline{M}$, proving our claim.

Let us remark that the condition stated in the above theorem is in particular fulfilled if we consider the ADS hull of a nonsingular ring. Indeed in this case we consider the ADS rings between $R$ and $Q:=E(R)$ and projections are$K$. We thus have $M=\sigma(S^{\prime }) + \sigma(T^{\prime })$. Since homomorphic images of $M$ have projective covers, Lemma 4.40 [@MM] shows that $\sigma(T^{\prime })$ contains a supplement $X$ of $\sigma(S^{\prime })$. In particular, we have $\sigma(S^{\prime }) \cap X<< X$. Since $\sigma(S^{\prime })$ is semisimple we conclude that $\sigma(S^{\prime }) \cap X=0$ and hence $M=\sigma(S^{\prime
}) \oplus \sigma(T^{\prime })$. Since homomorphic images of a local module are still local, we conclude that the terms appearing in $\sigma (T^{\prime
}) $ are local modules. The last statement is a direct consequence of Lemma 4.40 [@MM].

Let us mention that local rings which are not uniform give examples of semiperfect completely ADS modules which are not CS and hence not quasi-continuous.

The following corollary characterizes semiperfect $\pi c$-rings providing a new proof of Theorem


to the opposite. Yet, the rule is very stringent with respect to the issue of contributory negligence in cases such as these. In Redd v. Sokoloski, 2 So.2d 266, 268 (2d Cir. 1941), Judge (later, Justice) Hamiter stated:
"* * * [W]here a tenant has knowledge of the generally defective condition of a portion of the rented premises, but it reasonably appears that he might safely use it with the exercise of care, his use in such manner does not constitute contributory negligence that would bar his recovery in an action for damages resulting from the defects. If, however, he was aware of the defect causing the injury and it was such as to indicate to a reasonable-minded person that use of the defective portion was apparently and imminently+ g.x + ", " + g.y + ", " + g.z + ", " + g.w + ")");

    var m = bone.matrix;
    var q = new THREE.Quaternion();
    m.decompose(p, q, s);
    console.log(label + " - LOCAL: (" + q.x + ", " + q.y + ", " + q.z + ", " + q.w + ")");

    if(bone.parent !== null)
    {
        var gpm = bone.parent.matrixWorld;
        var gp = new THREE.Quaternion();
        gpm.decompose(p, gp, s);
        console.log(label + " - PARENT GLOBAL: (" + gp.x +


All relevant data are within the paper and its Supporting Information files.

Introduction {#sec005}
============

Albinism is a common clinical entity with an estimated prevalence of 1:17000 \[[@pone.0158815.ref001]\]. It is a heterogeneous \[[@pone.0158815.ref002]\], autosomal recessive or X-linked inherited disease caused by deficient melanin synthesis due to mutations resulting in different types of either oculocutaneous albinism (OCA1-4; OCA1A being the most severe type) \[[@pone.0158815.ref003]\], or ocular albinism (OA, X-chromosomal) \[[@pone.0158815.ref004]\]. Albinism of the eyes is clinically characterized by deficient or absent pigment in the fundus and iris. The latter may manifest with iris transillumination. Additional clinical signs are foveal hypoplasia, fundus hypopigmentation, refractive errors \[[@pone.0158815.ref003],[@pone.0158815.ref005]\], reduced contrast sensitivity \[[@pone.0158815.ref006]--[@pone.0158815.ref009]\], colour vision impairment, photophobia \[[@pone.0158815.ref001]\], amblyopia, and sometimes the use of a non-foveal retinal locus for fixation \[[@pone.0158815.ref010]\]. The optic chiasm usually containson a person's interests, frequently visited websites and searched topics, should be shared, based on the poll.

Despite the limited support, such tactics are in line with policies at companies like Facebook, which has not put any limits in place on ad targeting.

The majority of Americans polled, 59 percent, also said that websites should show political ads but said the companies should disclose who paid for the ad, how much it cost and whom the ad is aimed at, based on the poll.

The same poll found 20 percent of Americans said no campaign ads should be shown on any website, in line with the policy that was recently adopted by Twitter, and another 4 percent said sites should not show politics ads in the final month of an election


}
    //other methods - save, delete
    #endregion
}
}

Now here is the problem: note how I exposed the Context property above - I have doubts that this is actually intended, I feel like I'm breaking the pattern by doing it. I like a lot the idea that  everything is controlled through the repository in the same context and all, but I need some further methods which are not offered by the generic repository - so I made a separate CustomerRepository:
using System;
using System.Collections.Generic;
using System.Linq;
using System.Text;
using System.Web.Mvc;

namespace BusinessLogicLayer.Repositories
{
public class CustomerRepository: GenericRepository<Entities.Customer>
{
    public CustomerRepository(SharedContext ctx)
        : base(ctx)
    {  }

    public decimal GetCustomerBonusByFrequency()
  abundance of each chemical, and the measured active sampler concentrations and passive sampler masses were significantly positively correlated for 14 of 21 chemicals, for which correlations could be estimated. We found that measurements of many SVOCs originating from consumer products and typically found in the gas-phase (log KOA < 10) can be reliably ranked-and thus appropriate for epidemiological studies-using this PAS design. These SVOCs include diethyl phthalate, AHTN, HHCB, tris(2-chloroethyl) phosphate, dibutyl phthalate, and tris(1-chloro-2-propyl) phosphate, as well as methyl paraben, benzophenone, and benzophenone-3, which have not previously been measured by passive sampling. This PAS can be used in epidemiological studies involving consumer product chemicals and complements other novel exposure tools.


A Book Lover Brings Libraries to Darfuris

Darfur woman being testedf for her first pair of reading glasses sent by Book Wish Foundation

Photograph: Anne Goddard -- CORD

Our work in developing countries relies on forming genuine partnerships. Our partner in Chad is a 42 year old British humanitarian organization, one of the first on the ground in Chad helping the Darfuris — CORD. We spent a year developing this relationship, identifying specific needs. CORD runs the education programs for the Darfuris in the three camps we are currently focused on. In less than two years, we have received requests for targeted reading aid from 20 countries, many from Africa.

In addition to searching for new and used books, Bibliotarian.org finds books available for swapping from BookMooch and PaperBackSwap, two of theBartholomew Bretherton (1812-1866) a winner of the Grand National in 1840.

Before it was built, the Catholics in Rainhill had to travel to the Jesuit church in Prescot, Our Lady Help of Christians Church or St Bede's Church in Widnes.

Construction
Bartholomew Bretherton chose the location where the church would be built, on the Warrington Road, in direct sight of anyone travelling down the main road through the village. He also chose the design for the church and wanted it to be dedicated to his own patron saint, Saint Bartholomew. The design he chose was by a local architect, Joshua Dawson. The architect went to Rome to look at the Church of San Bartolomeo all'Isola there. In 1838, building started and the stones were taken from a local quarry that the


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Plot

Late one night at Plumber Headquarters, Khyber sneaks in and steals the Nemetrix, leaving behind a taunting message for Ben in the process. Ben, however, is unconcerned. He has been having a string of good luck including: finding a Tayden, getting a month of free drinks from a Mr. Smoothy's scratch card, and Jerry giving him some Sumo Slammers on Ice tickets in exchange for free drinks, leading him to believe it's his lucky day.

Meanwhile, at the Black Hole, Khyber confronts Trumbipulor, or more accurately, his new partner Skurd, a small, green parasite-like creature known as a Slimebiote with the ability to feed on DNA and use it to create weapons or extra limbs. Skurd, initially defensive, quickly jumps from alien to alien, citing thathe is impossible to remove from his host if he is unwilling to be removed. Khyber introduces Skurd to the Nemetrix, a database of exotic DNA, intending to use Skurd's unique abilities to allow him to use the Nemetrix himself without suffering the mental degradation. Enticed by the prospects of a whole library of DNA to sample, Skurd agrees.

The two celebrate their new partnership over drinks. Meanwhile, at Mr. Smoothy Ben is making use of his scratch card for a month of free drinks, continuing to assert that it's his lucky day, when Khyber appears. Ben transforms into Heatblast to fight him, only for Skurd to coat Khyber in Crabdozer armor. After a brief exchange in which Heatblast is on the losing end, Blukic and Driba accidentally teleport


a subject upon which they frequently corresponded.213

212 The Lusiads, 2 vols., 1878. Says Aubertin, “In this city (Sao Paulo) and in the same room in which I began to read The Lusiads in 1860, the last stanza of the last canto was finished on the night of 24th February 1877.”

213 Burton dedicated the 1st vol. of his Arabian Nights to Steinhauser.

53. The Facetious Cannibals.

Wherever Burton was stationed he invariably interested himself in the local archaeological and historical associations. Thus at Santos he explored the enormous kitchen middens of the aboriginal Indians; but the chief attraction was the site of a Portuguese fort, marked by a stone heap, where a gunner, one Hans Stade, was carried off by the cannibals and all but eaten. Burton used to visit the1. Introduction {#S1}
===============

Frozen-thawed embryo transfer (FET) in in-vitro fertilization (IVF) cycles is a critical step to increase the rate of pregnancy and to prevent ovarian hyper stimulation syndrome (OHSS) (1).

Improved laboratory techniques by transferring fewer embryos in the fresh transfer cycles have led to an increase in the number of FET cycles (2). One of the main principles in FET is endometrial preparing for implantation of the thawed embryos (3). Points affecting FET outcome include: embryo quality, endometrium and embryo synchronization, and the reception of endometrial (4). Although increasing FET have significant effects on outcome, there is no accepted best protocol in women with ovulation for endometrial preparing (2).

There are different ways for endometrial preparation1) Artificial cycle FET (AC-FET): In this method, estrogen and progesterone are administered in


in the HR cycle, estrogen and progesterone does not suppress completely the pituitary gland and dominant follicle. If this follicle leads to spontaneous luteinization, the endometrium might have been exposed to progesterone earlier, which increases the risk of incorrect timing of the transfer, implantation, and pregnancy rate (11).

In Huang\'s study, the live birth rate was 38.89% and the clinical pregnancy rate was 47% in the letrozole FET cycle (12).

Letrozole rapidly absorbs and reaches maximum blood concentration 1 hr after its oral administration and also high bioavailability and a short half-life (45 hr), resulting in complete removal of the drug during the implantation period. The administration of letrozole at a low dose induces single follicular development and it has a high rate of ovulation; hence, preparing the endometrium forabdominal region can comprise 1000 slices as an order of magnitude, it is evident that their evaluation for body fat quantification and localization needs fully automated algorithms. The paper at hand describes the development and validation of such an algorithm called "CT-histogram-based fat estimation and quasi-segmentation" (CFES). The approach can be characterized as a weighted least squares method dealing with the gray value histogram of single CT-slices only. It does not require any anatomical a priori information nor does it perform time-consuming feature detection on the CT-images. The processing result consists in numbers quantifying the amount of abdominal body fat and of muscle-, organ-, and connective tissue. As a by-product, CFES generates a quasi-segmentation of the slices processed differentiating fat from muscle-, organ-, and connective tissue. The tool


said.

He was in the NDA hockey team and said to be an excellent volleyball player. According to the army, he was tipped to go for a Young Officers' course in September.

"He was an absolutely outstanding officer, outstanding sportsman. Kashmir has lost its son... We have lost a young, promising officer. I am sure when the people of Kashmir realise this, they will join hands and hit back at perpetrators," said Lieutenant General Abhay Krishna, Colonel Commandant of the Rajputana Rifles.

"After he successfully completed his training, he was very well integrated with his troops. He was very very focused. The troops loved him. He used to beat everyone in games. I remember whenever I gave him a task - he used to take it as a challenge. For memagazine
• Runs numerous continuing education courses throughout the UK, including postgraduate certificates and a Masters programme
• Maintains contacts with small animal practitioners through regional volunteers, who organise local CPD meetings
• Through its charity, PetSavers, funds clinical investigations into the diseases of companion animals
• Encourages veterinary surgeons and nurses to develop their professional skills
• Provides a forum for the discussion of issues of importance to veterinary surgeons and nurses in small animal practice and submits evidence on their behalf to the British Veterinary Association and the Royal College of Veterinary Surgeons as well as to government departments
• Liaises with other veterinary professionals through regular meetings
• Represents member interests internationally through various European and world small animal organisations


sinus infections. Further, one of the reasons you keep hearing how crucial exercise is involves your lymphatic system, because movement is essential for it to function as it was designed to do.

It doesn't have a pump, so it relies on muscle contractions — aka exercise — to "shake things loose," so to speak, which helps your body in its detoxification process. Further, many of your lymph vessels run just below your skin's surface, which is how brushing your skin can impact how well your lymph glands perform. Brushing your skin is an innovative way to gently cleanse and protect your skin and improve circulation.

There are brushes for your hands, feet and nails, face (which have softer bristles), hair and body. Besides the type for dry brushing, there areslipped down to the floor. Nitin felt extremely embarrassed. He heard her gasp and run away from the room without bothering to find out if he was hurt. Nitin lay on the floor, a picture of abject misery. Beauty rushed to his side and whimpered sympathetically. Pluto, forgetting his own illness, flew down and nibbled at his shirt.

“Even animals and birds have more sympathy than pretty girls,” he thought.

Slowly he lifted himself up with the strength of his arms and slid into his wheel chair. More than the physical hurt was the deep gnawing pain of desolation within his heart.

Though Pluto resumed his vigil at the window, Nitin kept away. He worked feverishly at his compositions, and during those months of deep anguish and loneliness, he composed some


plant-based foods.

According to a survey conducted by Sainsbury’s at the beginning of the year, 91 percent of the UK population now identify themselves as flexitarian.

Sainsbury’s has witnessed the benefits of this demand; it has seen a 65 percent increase in plant-based product sales year-on-year. The number of people searching for vegan food online at the supermarket has also increased by 85 percent.

“We’re seeing increasing demand for plant-based products,” said Rosie Bambaji — a plant-based buyer at Sainsbury’s — in a statement. “With the unstoppable rise of ‘flexitarianism’ in the UK, we are exploring further ways to make popular meat-free options more accessible.”

John Lewis’ vegan cheese ploughman’s is priced at £5.25.as under $\mathbb{P}$; i.e. we have $\mathbb{P}^\alpha(X_{n+1} = z \mid X_n = y) = \mathbb{P}(X_{n+1} = z \mid X_n = y)$ whenever $\mathbb{P}^\alpha(X_n = y) > 0$.
$\mathbb{P}^\alpha(X_0 = y) = \alpha(y)$ for all $y \in E$.

Note that all of this makes sense for any probability distribution $\alpha$ on $E$, not necessarily a stationary distribution.  $\mathbb{P}^x$ is defined similarly except that in place of (3), we have $\mathbb{P}^x(X_0 = x) = 1$.
Let us assume throughout that $\alpha(x) > 0$ since otherwise, as noted, everything is trivial.
The basic idea is that the process $X_n$ looks the same under $\mathbb{P}^\alpha$ conditioned on $X_0 = x$ as it does under $\mathbb{P}^x$.  Specifically:
Lemma 1. For every $x_1, \dots, x_n$, we have
$$\mathbb{P}^\alpha(X_n = x_n, \dots, X_1 = x_1 \mid X_0 = x)


of functions that must be accorded a similar consideration are the dynamic or “hormic” functions (from the(...)

A short definition of devotion by Roberto Assagioli from his book Psychosynthesis Typology: "... devotion is often called love, but in reality it has a tone and a quality decidedly different from that of love, a fact that justifies and even requires the use of different terms to describe(...)

Definition of disidentification
In this glossary item, you will find Roberto Assagioli's dis-identification and self-identification exercise and some important discussion about it. If you wish to explore the technique, you are welcome to use the 7 meditations I have created.
Roberto(...)

Empathy. “Regardless of one's intellectual understanding, genuine existential understanding is not possible without empathy, i.e., the projection of one's consciousness into that of another being. ItsConference in May 1958 much discussion took place about the Self and it occurs to us that readers of(...)

A short definition of the will, by Roberto Assagioli: "The will is the synthetic power which coordinates, organizes and directs all the other faculties and, therefore, should have a greater development in order to truly master them, while nearly always the opposite is the case. The will(...)

A short definition of thinking, by Roberto Assagioli Reflective Meditation Its simplest definition is to think; an accurate but limited definition, since clear ideas on the function of thinking are not common property. It has been stated that "the mind thinks in us," rather than it(...)

A definition of transformation by Roberto Assagioli from his book The Act of Will. "Law X—The psychological energies can


[Unknown primary cancer: revision of our experience. Preliminary study].
The unknown primary cancer is a hazardous diagnostic and limited therapeutic medical problem with too much variability. It is possible to design a standard procedure using the world-wide scientific literature, which could be able to decrease patient suffering and to avoid unnecessary sanitary costs, without diminishing survival. First of all we have conducted a retrospective descriptive study including all the patients with unknown primary neoplasms detected in our Internal Medicine service during 1994. We have met 18 cases, most of them adenocarcinoma and undifferentiated carcinoma, and hepatomegaly as clinical presentation. In 8 cases (44%) was the primary tumour site identified, mainly with CT. Only 3 (16%) patients were alive at the end of the study, with a mean survival offemale contestants will have to wear clothes in compliance with the rules of the Islamic Republic of Iran.

It’s not for the first time that Heena has withdrawn her name from a tournament being held in Iran.

“Yes, I have done it earlier as well. Two years back, I had decided not to go to Iran for the same reasons. It’s only Iran which insists on such a code. It does not happen in other nations,” Heena said.

Meanwhile, the President of Rifle Association Rajendra Singh has said that Indian shooters have always respected the Iranian traditions.

“We have good relations with Iranian shooting federation and we respect their culture and tradition. All females, including tourists and diplomats, wear hijab when they visit Iran. All other Indian female shooters, except Heena, have


Background
==========

Malignant gliomas account for approximately 30% of all intracranial tumors, and of them, glioblastoma multiforme (GBM) is considered as the most frequent and aggressive type. Removal of GBM by surgical resection is usually not feasible due to the highly diffuse infiltrative growth and recurrence rate \[[@B1]\]. A multicenter study has shown that addition of concurrent temozolomide (TMZ) to radical radiation therapy improves the survival in patients who suffered from GBM \[[@B2],[@B3]\]. These studies have demonstrated an improvement for patients who received TMZ, compared to those who did not, in the median survival time and in the 2-year survival rate (14.6 vs. 12 months, 27% vs. 10%, respectively). Unfortunately, the survival rate remains low using TMZ, and it prompts investigators to seek new and more effective chemotherapeutic agents foradjuvant treatment with surgery, we tested if the therapeutic ability of BO-1051 could be translated into antitumor activity. In this study, we investigated the effects of BO-1051 on the radiosensitivity of a panel of three human glioma cell lines, and we found that treatment with BO-1051 at nanomolar concentrations sensitizes the glioma cells to radiation-induced cellular lethality. These data indicate that BO-1051 enhances tumor radiosensitivity *in vitro*and *in vivo*. Moreover, this sensitization correlates with its enhancement arrest in the radiosensitive cell cycle phase and the delayed dispersion of phosphorylated histone H2AX (γ-H2AX) foci, which suggests an inhibition of the repair to the DNA double-strand breaks (DBSs).

Materials and Methods
=====================

Cell lines and treatment
------------------------

This research followed the tenets of the Declaration of Helsinki. All samples were obtained after patients provided informed


single cells were seeded into a 25-T flask, and after 6 h, to allow for cell attachment (but no division), the cells were treated with 0, 50, 100, 200 or 400 nM BO-1051. At 0, 6, 12 and 24 h after the BO-1051 addition, the BO-1051-containing medium was removed; the cells were washed with sterile PBS, and fresh media was added. After 10 to 14 days of incubation, colonies were fixed with methanol and stained with Giemsa. The number of colonies containing at least 50 cells was determined, and the plating efficiency (PE) and surviving fractions (SF) were calculated. The SF of cells exposed to × nM BO-1051 for t h was calculated as \[[@B15]\]:

$$\text{SF}_{xnM,thr} = \frac{\text{PE}_{\text{xnM,thr}}}{\text{PE}_{\text{0nM,thr}}}$$

This protocol was used in an attempt to eliminate any effects ofwas used. Mice bearing s.c. xenografts (\~150 mm^3^) were stratified by size and randomized into 4 groups: control, BO-1051 alone, irradiation alone (4 Gy), or combined BO-1051 plus radiation. For the BO-1051 treatments, mice were i.p. injected with dosage at 50 mg/kg on days 0, 3 and 6. The growth rates for the GBM-3 tumors exposed to each treatment are shown in Figure [6A](#F6){ref-type="fig"}. For each group, the time for tumors to grow from 150 to 1500 mm^3^(i.e., a 10-fold increase in tumor size) was calculated using tumor volumes from the individual mice in each group (mean + SD). The time required for tumors to reach 10-times the starting volume increased from 20.2 days for control mice to 29.5 days for BO-1051-treated mice. Irradiation treatment alone increased the


tumor volume minus the number of days for tumors in the BO-1051-only group to reach the same size.

\# Normalized growth delay for the BO-1051+IR group divided by absolute growth delay for the radiation-only group.

Discussion
==========

Although human GBM is one of the most radio-resistant tumors, radiotherapy remains routinely applied for patient treatment. Lots of efforts are made to develop methods for enhancing the radiosensitivity of GBM for promising therapy. Previous studies have shown that temozolomide (TMZ) combined with radiation exposure results in an increase of survival rate in a subset of human tumors \[[@B3],[@B25],[@B26]\]. Clinical studies also indicate that delivery of TMZ during radiotherapy increases survival rates of GBM patients, which suggests that this DNA alkylating agent can enhance the radiosensitivity of GBM \[[@B2],[@B27],[@B28]\]. Based on these previous studies, moreHELLO

I'm Ana, from Porto, Portugal, a former architect that found her passion in contemporary jewelry.Here I share fragments of my life, work and many sources of inspiration. Welcome, grab a cup of coffee (or a glass of wine!) and stay for as long as you like.

CURRENTLY

ABOUT

CATEGORIES

All texts, works and photographs posted on this blog are mine unless otherwise stated. Thank you for respecting copyright.If you don't want to be featured or see any link or image incorrectly credited, just send me an email and the error will be rectified.

Today I present you an amazing creative duo: Ildiko and Flavia. They live in Romania and are the heart and soul of harem6, the studio where they give wings to their fertile imagination, creating artistic objects that range from drawings


animals we both make them and I also started drawing, Ildiko encouraged me to do that. I am happy I started it again. In the jewelry pieces we both do the modeling and painting. At this moment Ildiko makes the drawings on the jewelry objects.

4. You love to experiment different mediums and even though this is one of the most interesting aspects of your work, your art in clay is probably the most personal way to express yourselves. Tell us about your choices and your favorite mediums to work with.

At the moment we love to work with clay, fabrics, pencils and a camera. But we all know that people like working with the tools they know how to work with.

You cannot say that you don’t like to playthe piano if you have never played it you can only say you can’t play it. So one has to start doing something in order to know whether he likes it or not. We are looking forward for the new materials which we’ll discover during our artistic evolution, if we’ll feel the need for some new materials at a certain point.

5. Either in drawing, sculpture or wearable objects you create an amazing fable world, with curious animals and strange creatures. How are they born? What inspires you? Share your creative process with us.

All these works reflect our personalities, they are fragments of our souls. We sometimes imagine them on a beautifully decorated stage where anything is possible and this is such a beautiful image, full of possibilities and


objects like pendants or brooches. Do you consider yourselves more artists or crafters? Do you think there’s actually a big difference or there’s only a thin line separating these two concepts nowadays?

We think of ourselves as artists. We think there is a process of transformation, one’s first a crafter and then an artist. You become an artist once you decided that’s what you want to be and you seek for your own identity with all your strength. But of course there are also people who don’t know they are artists, they simply are and that’s why they are special.

7. What is creating for you: a profession, a passion, a necessity, a life style or a hobby?

It certainly is our life.

8.Through your shop your creations travel all around thesensibility and required attention to detail is known as 3d CAD rendering services to our valuable clients.

Silicon Valley offers completely incorporated Electrical Engineering Institutional Projects and detail that consolidates suites of tools with consequently connected capacities. With the solid field experience Silicon Valley helps its level best to meet all important electrical guidelines and regulations for your institutional building. A development of an Institutional Structure is the mix of numerous designing orders and one of them is Electrical Engineering Services where the extent of electrical building administrations in taking after fields:

Silicon Valley is the most incredible organization for creating Electrical Engineering Industrial Projects. Our Silicon Valley sets the standard for incredibleness and convenience in the business. We are all around arranged with proficient lineup of electrical architects, CAD


to get focused on results from the Cement Plant Projects.

In the Cement business, each plant comprises of multilayered subsystems and complex procedures. Be that as it may, what at last matters the most for your plant and generation is proficiency. That is the reason you require an accomplice who joins specialized skill with monetary and vitality proficiency forms.

Switchgear and control boards are found in force creating stations, transformer stations, circulation substations, business and institutional structures, mechanical plants and production lines, refineries, paper factories, metal smelters and whatever other place where electric vitality is used or electric force is disseminated to any number of zones. We Silicon Valley are putting forth Electrical Control Panel Design Services at the best rates which will suit your financial plan.

Our electrical drafting andideas of the sorts of issues likely to influence implementation within the PHIT Partnerships. For example, wider experience of health policy implementation \[[@B6]\] highlights that it:

• often results in unintended and unwanted consequences;

• is always contested by policy actors --- not just politicians or interest groups contesting political agendas, but also, and as importantly, those actors working within the implementation chain, such as managers, health workers, patients, civil society organizations;

• is strongly influenced by the meanings policy actors attribute to features of design or to policy goals, which influences how they understand them and then react to them.

The implications are that managing implementation requires deliberate engagement with the values, interests, and understandings of those actors who might block or subvert policy change.

Experience of scaling up innovative public health


trigger mechanisms, and the underlying assumptions about how and why they generate the expected behavioral changes, is the central focus of evaluation. In theory driven inquiry, these ideas are developed and examined through the process of evaluation and across several case studies of intervention, and are revised and refined in response to empirical experience. The primary question of focus in such evaluation is "what works for whom and in what circumstances"?

A burgeoning range of development and social policy literature provides guidance about how to develop these theories of change \[[@B11]\]. Drawing specifically on four key sets of questions \[[@B12]\] could provide the starting point for understanding the experience of each PHIT Partnership. These questions are:

• What overall health system change/situation does it seek to achieve? (that is plausible$4.00

02LH9-5 - CAUSE OF CURSES - C. Fox[tape]

02LH9-5 - Carl Fox - CAUSE OF CURSES - $4.00 Donation - If we don't get to the cause of the curse, it will keep coming back. If you don't clean it out, eventually there is no room for growth. Our obedience to Him will bring blessings in our life, disobedience will bring curses. Until we repent, the curses will continue down the family, like an avalanche. We can also curse others around us by our actions or words.


and then that was it for the year.To celebrate this change in the weather I dusted off the MTB from the garage which has been in winter hibernation and took it on a 15 mile round trip on the canal, not a great idea as this morning I can hardly walk let alone sit down. Still my fitness regime has started, this time next year you wont recognise me :)

10 May 2008

Finally a little sun and dry weather has arrived, so on a lovely evening and taking directions from "The Walking Englishman" website we set out to the edge of town where Lancashire becomes Yorkshire and the Landscape becomes moors and craggs.

I have never seen these stones before or heard of them and our route to them followsMartha Lloyd (principal)

Martha Lloyd (7 September 1860 – 24 August 1943) was a third generation English school principal. In her spare time she was a mountaineer and a director of the London Missionary Society.

Life
Lloyd was born in the parish of Ebley near Stroud in 1860 to Anna Lloyd and her husband. Her grandfather was Benjamin Parsons who had founded and led schools. She was educated at her mother's school, but a university education was denied her because of the cost (although her brother did attend Cambridge University).

Lloyd was an early member of the Ladies' Alpine Club which was based in London. She was the first woman to climb the Sudlenspitze., This mountain had been first climbed by Alexander Burgener in 1870. She and her mother supported the


Effects of soil water stress and twospotted spider mites on net photosynthesis and transpiration of apple leaves.
Soil water stress and twospotted spider mites (Tetranychus urticae Koch) were tested for their influence on the content and activity of leaves of greenhouse grown Delicious apple trees. Soil water stress caused reductions in net photosynthesis (Pn), transpiration (Tr), and shoot growth. Leaf water potential was decreased by both water stress and mite feeding. Feeding of 15 adult mites/leaf for 28 days resulted in a 16% reduction in Pn while an initial population of 10 mites leaf/left to develop for 20 days reduced Pn by 27%. Mite feeding reduced leaf nitrogen and non-structural carbohydrate levels when sampled 20 days after placement on the leaf. There was no interaction between the changed physiologycould be the final. Click Menu and select Mortgage Aid. After that, click the Options menu. Less see a mortgage or keep in touch with Nationstar Mortgage professionals. They’ll allow you get exactly what matches your own situation.

Mr. Cooper or Nationstar Mortgage will see a means to decrease your monthly obligations in the event that you would like to simply take loan fluctuations. For listing, you meet the requirements for loan fluctuations. They provide several tactics to reduce regular payments. Your rate of interest is likely to be lower using the aid of Nationstar. It might also extend the amount of the mortgage. Continue to maintain your upgrades with Nationstar for advice on the status of one’s Nationstar Mortgage status switch.

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Born and bred Colner threatened with deportation

Dominic Collis

A young man, born and bred in Colne, is being threatened with deportation because he is not officially a British citizen.

Former Primet High pupil Shane Ridge (21) discovered the shocking news after applying for a passport and being told he does not have an automatic right to remain in the UK.

Rather than the hoped-for passport, Shane received a letter from the Home Office informing him that his driving licence would be revoked as he had “no lawful basis to be in the UK”.

The reason, it transpires, is because his mother Sue Ebbs was born in Australia and is not married to his father.

British law states that for any child who was born before July 2006, the father’s British nationality will onlyQ:

YQL geocoding returning different results from different IP's

I'm using yahoo geocoding YQL to get lat/lon for a user-entered location.  The strange thing is that I get different results when querying from different IP addresses.  For example, this query attempts to resolve London, United Kingdom:
http://query.yahooapis.com/v1/public/yql?q=select%20*%20from%20geo.places%20where%20text%3D%22london%2C+United+Kingdom%22&appid=my_app_id

(before you ask, my_app_id is the real ID, which, for obvious reasons, I'm not showing here)
When I run this from my local machine (using wget in console), I get valid results.  I get the same results when I run it from our test server.  However when I run it from our live server, I get a different response with count="0".  Because of this, the app is working on my local machine and on our test server, but is failing on


feet away from them across from yellow tape police had set up. The activists demanded that the men explain why they believe gays should be killed, with some taunting the churchgoers as “closeted” queers themselves.

The anger was palpable as some screamed at the men, who sometimes laughed and took cellphone video of the protest, but otherwise rarely acknowledged the activists.

Asked if anyone could observe the service, one man at the entrance said, “You have to be a member,” prompting protesters to request to join.

During the service, which appeared to be attended by several dozen people, the church closed the blinds and little was visible from the outside. Jimenez, it seemed, slipped out a back door at the end of the night, and police helped escort other parishioners towe can save your preferences for cookie settings.

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