a criminal trial from any trial judge to the administrative judge or his designee...." In Frazier (id. at 450, 470 A.2d 1269), as well as in Hicks v. State, supra, 285 Md. at 317, 403 A.2d 356, we quoted with approval the statement in Guarnera v. State, 20 Md. App. 562, 573, 318 A.2d 243, cert. denied, 272 Md. 742 (1974), that by enacting § 591, "the Legislature ... has denied all judges but the administrative head of the court authority to exercise ... [the postponement] power." See also Hughes v. State, 288 Md. 216, 229, 421 A.2d 69 (1980). This was acknowledged in the instant case by the trial judge on August 4, 1981, who stated that a "request for a postponement of the criminal case is746 for postponing cases beyond the 180-day period.[4]

(3)
Finally, we address the argument in Judge Rodowsky's dissenting opinion that State v. Hicks should be overruled.
In arguing that the sanction of dismissal is unnecessary to secure compliance with § 591 and Rule 746, Judge Rodowsky relies on selective statistics designed to show that reductions in the average time between the filing of a criminal case and the trial, and between the filing and ultimate disposition, were being achieved in Maryland even before the Hicks decision in June 1979. Preliminarily Judge Rodowsky overlooks the fact that, although this Court's decision in Hicks was rendered in 1979, we promulgated Rule 746 in 1977 intending to "put teeth" into the requirements governing the assignments of criminal cases for trial. Hicks, 285 Md. at


area is consistent with the prevailing view in other jurisdictions having statutes or rules similar to § 591 and Rule 746. The overwhelming majority of those jurisdictions, either by legislative enactment or court interpretation, hold dismissal to be the appropriate sanction if a defendant has not been brought to trial within the required time period. See, e.g., Westdahl v. State, 592 P.2d 1214, 1216 and n. 6 (Alaska 1979); Healey v. State, 389 So.2d 278 (Fla.App. 1980); Jeffries v. State, 140 Ga. App. 477, 231 S.E.2d 369, 371-372 (1976); People v. Richards, 81 Ill.2d 454, 43 Ill.Dec. 700, 703, 410 N.E.2d 833, 836 (1980); State v. Peterson, 288 N.W.2d 332, 335 (Iowa 1980); State v. Kinstler, 207 Neb. 386, 299 N.W.2d 182, 185-186 (1980); People v. Conway, 74defendant before the court pursuant to Rule 723.
b. Change of Trial Date.
Upon motion of a party made in writing or in open court and for good cause shown, the county administrative judge or a judge designated by him may grant a change of trial date."
[2]  The trial judge's statement reflects a confusion between the requirements of § 591 and Rule 746, on the one hand, and constitutional speedy trial analysis on the other. See State v. Frazier, 298 Md. 422, 428-429, 470 A.2d 1269 (1984); Goins v. State, 293 Md. 97, 106-109, 442 A.2d 550 (1982); State v. Hicks, 285 Md. 310, 320, 403 A.2d 356, on motion for reconsideration, 285 Md. 334, 403 A.2d 368 (1979).
[3]  Calhoun v. State, 295 Md. 53 (1982).
[4]  It


is noteworthy that courts in other jurisdictions have reached the same conclusion. In discussing its 180-day speedy trial statute, the Kansas Supreme Court concluded that a continuance beyond the 180-day period must be granted before the period expires. In State v. Cox, 215 Kan. 803, 805, 528 P.2d 1226 (1974), the Court stated, "[w]e think it clear under the language of 22-3402 that in order for the continuance exception to be brought into play, the state must show that a continuance was granted ... during the 180-day statutory period for one of the authorized reasons." See also State v. Sanders, 209 Kan. 231, 233, 495 P.2d 1023 (1972).

The Supreme Court of Ohio, when faced with facts similar to those in the instant case, reversed the defendant's conviction andaccuracy. These lead to a more reliable product with smaller unit variability and lower manufacturing costs.
Accurate and repeatable location of a part requires defining datums. Accurate location is needed for manufacturing, assembly and inspection. A three dimensional, curvilinear part, such as a heart valve stent, complicates the method of defining these datums. One widely used method of inspection uses 6 stops on 3 mutually perpendicular datum planes to locate the part. This method, called 3-2-1 location is described in many engineering texts including xe2x80x9cFundamentals of Tool Design,xe2x80x9d 2nd Edition, Hoffman (Ed.), Society of Manufacturing Engineers, 1984 pp. 142-158, 170. Stops are used to define the first, usually horizontal, plane, and to locate the part against a vertical plane. Any additional stops, for example, a fourth stop on the


Newfoundland – AutoGuide.com Newshttp://www.autoguide.com
Fri, 09 Dec 2016 16:03:28 +0000en-UShourly1https://wordpress.org/?v=4.6.1AutoGuide.com NewsNewfoundland – AutoGuide.com Newshttp://www.autoguide.com/auto-news/wp-content/themes/autoguide-proper/img/logo_autoguide_red.gifhttp://www.autoguide.com
Kia Canada to Compete in Targa Newfoundland in Partnership with MADD Canadahttp://www.autoguide.com/auto-news/2011/09/kia-canada-to-compete-in-targa-newfoundla%e2%80%8bnd-in-partnership-with-madd-canada.html
http://www.autoguide.com/auto-news/2011/09/kia-canada-to-compete-in-targa-newfoundla%e2%80%8bnd-in-partnership-with-madd-canada.html#respondSun, 04 Sep 2011 00:36:46 +0000http://www.autoguide.com/auto-news/?p=81987Kia Canada to Compete in Targa Newfoundland in Partnership with MADD CanadaTarga Newfoundland, the ultimate North American tarmac rally, is organized every September for seven days and travels across 2,200 kilometers, or 1,200 miles, of amazing central Newfoundland road. South Korean automaker Kia‘s Canadian operations are set to participate in the 2011 Targa Newfoundland Rally, which will be their second consecutive year at the event. This... more]]>

Targa Newfoundland, the ultimate North American tarmac rally, is organized every September for seven days and travels across 2,200 kilometers, or 1,200 miles, of amazing central Newfoundland road.

South Korean automaker Kia‘s Canadian operations areindictment accusing him of mail and wire fraud, income tax evasion and filing a false income tax return.

The indictment doesn't say how much Waters allegedly took from his employer, but in a civil suit Cafesjian had filed against the man, he claimed Waters embezzled at least $2.8 million between 2004 and 2009.

The criminal complaint alleges improprieties between 1999 and March 2012.

Waters had gone to work for Cafesjian at West Publishing in 1994, two years before Cafesjian retired as an executive vice president. Cafesjian, a major shareholder in the company, was known in part for his philanthropy and civic work. In 1988, Cafesjian led the effort to save the merry-go-round at the Minnesota State Fairgrounds.

Cafesjian and others contributed more than $2 million to save the 1914 amusement. The 68-horse


if( command == fMagFieldZCmd )
  {
    fEMfieldSetup->SetFieldZValue(fMagFieldZCmd->GetNewDoubleValue(newValue));
    // Check the value
    G4cout << "Set global field value to " <<
      fEMfieldSetup->GetGlobalFieldValue() / gauss << " Gauss " << G4endl;
  }
  if( command == fMagFieldCmd )
  {
    fEMfieldSetup->SetFieldValue(fMagFieldCmd->GetNew3VectorValue(newValue));
    // Check the value
    G4cout << "Set global field value to " <<
      fEMfieldSetup->GetGlobalFieldValue() / gauss << " Gauss " << G4endl;
  }
  if( command == fLocalMagFieldCmd )
  {
    fEMfieldSetup->SetLocalFieldValue(fLocalMagFieldCmd->GetNew3VectorValue(newValue));
    fEMfieldSetup->UpdateField();
    // Check the value
    G4cout << "Set local field value to " <<
according to certain rules, as an aid to calculating sums of money.

The Antikythera mechanism is believed to be the earliest mechanical analog "computer", according to Derek J. de Solla Price.[6] It was designed to calculate astronomical positions. It was discovered in 1901 in the Antikythera wreck off the Greek island of Antikythera, between Kythera and Crete, and has been dated to circa 100 BC. Devices of a level of complexity comparable to that of the Antikythera mechanism would not reappear until a thousand years later.

The sector, a calculating instrument used for solving problems in proportion, trigonometry, multiplication and division, and for various functions, such as squares and cube roots, was developed in the late 16th century and found application in gunnery, surveying and navigation.

The planimeter was a manual


of binary logic circuits in a relatively compact space.

The first practical ICs were invented by Jack Kilby at Texas Instruments and Robert Noyce at Fairchild Semiconductor.[47] Kilby recorded his initial ideas concerning the integrated circuit in July 1958, successfully demonstrating the first working integrated example on 12 September 1958.[48] In his patent application of 6 February 1959, Kilby described his new device as “a body of semiconductor material ... wherein all the components of the electronic circuit are completely integrated.”[49][50] Noyce also came up with his own idea of an integrated circuit half a year later than Kilby.[51] His chip solved many practical problems that Kilby's had not. Produced at Fairchild Semiconductor, it was made of silicon, whereas Kilby's chip was made of germanium.

This new development heralded anFlash memory blurs the distinction between ROM and RAM, as it retains its data when turned off but is also rewritable. It is typically much slower than conventional ROM and RAM however, so its use is restricted to applications where high speed is unnecessary.[66]

In more sophisticated computers there may be one or more RAM cache memories, which are slower than registers but faster than main memory. Generally computers with this sort of cache are designed to move frequently needed data into the cache automatically, often without the need for any intervention on the programmer's part.

I/O devices are often complex computers in their own right, with their own CPU and memory. A graphics processing unit might contain fifty or more tiny computers that perform the calculations necessary to display


unique architectures that differ significantly from the basic stored-program architecture and from general purpose computers.[71] They often feature thousands of CPUs, customized high-speed interconnects, and specialized computing hardware. Such designs tend to be useful only for specialized tasks due to the large scale of program organization required to successfully utilize most of the available resources at once. Supercomputers usually see usage in large-scale simulation, graphics rendering, and cryptography applications, as well as with other so-called “embarrassingly parallel” tasks.

Networking and the Internet

Computers have been used to coordinate information between multiple locations since the 1950s. The U.S. military's SAGE system was the first large-scale example of such a system, which led to a number of special-purpose commercial systems such as Sabre.[72]

In the 1970s, computer engineers at research institutions throughout themodern computers boot entirely automatically by reading a boot program from some non-volatile memory.

^However, there is sometimes some form of machine language compatibility between different computers. An x86-64 compatible microprocessor like the AMDAthlon 64 is able to run most of the same programs that an Intel Core 2 microprocessor can, as well as programs designed for earlier microprocessors like the Intel Pentiums and Intel 80486. This contrasts with very early commercial computers, which were often one-of-a-kind and totally incompatible with other computers.

^High level languages are also often interpreted rather than compiled. Interpreted languages are translated into machine code on the fly, while running, by another program called an interpreter.

^It is not universally true that bugs are solely due to programmer oversight. Computer hardware may fail or may itself


have a fundamental problem that produces unexpected results in certain situations. For instance, the Pentium FDIV bug caused some Intelmicroprocessors in the early 1990s to produce inaccurate results for certain floating point division operations. This was caused by a flaw in the microprocessor design and resulted in a partial recall of the affected devices.

^The control unit's role in interpreting instructions has varied somewhat in the past. Although the control unit is solely responsible for instruction interpretation in most modern computers, this is not always the case. Some computers have instructions that are partially interpreted by the control unit with further interpretation performed by another device. For example, EDVAC, one of the earliest stored-program computers, used a central control unit that only interpreted four instructions. All of the arithmetic-relatedA versatile method for quantification of DNA and PCR products based on time-resolved EuIII luminescence.
A versatile and robust method for the determination of DNA and PCR products (<500 bp) is presented, based on a mix of an Eu(III) chelate and acridine orange (AO). The nucleic acid selective stains acridine orange (AO) and ethidium bromide (EB) quench the luminescence of the bimetallic [Eu(2)(L(C2))(3)] and of other monometallic chelates such as the macrocyclic complex [Eu(L(kel))], even at very low molar ratios. Stern-Volmer plots of the metal-centered emission intensities (F(0)/F) and Eu((5)D(0)) lifetimes (tau(0)/tau) show the AO quenching being purely dynamic with K(D) = 6.7 x 10(5) M(-1) for [Eu(2)(L(C2))(3)] and 1.6 x 10(6) M(-1) for [Eu(L(kel))], and bimolecular rate constants k(q) = 2.7 x 10(8) M(-1) s(-1) and 3.4 x


Characterization of Atypical Preeclampsia.
To characterize patients with atypical preeclampsia (PE), in relation to socio-demographic characteristics, clinical presentation, maternal complications and perinatal outcome. Between July 1, 2011 and November 30, 2013, a cohort was created of women attended at a Obstetric High-dependency Unit who met criteria for atypical PE: gestational hypertension with severe hypertension or symptoms or laboratory signs suggestive of microangiopathy/hemolysis; normotensive proteinuria with the presence of symptoms or laboratory signs suggestive of microangiopathy/hemolysis; presence of PE or eclampsia or HELLP syndrome appearing after 48 h postpartum, and, PE or eclampsia appearing before 20 weeks of pregnancy. A total of 200 women fulfilling criteria for atypical PE, were included: 61.5% corresponded to non-proteinuric gestational hypertension, 35.5% to normotensive proteinuria and 3% to PE/eclampsia in late postpartum. Criteria forof Belleville, Illinois verbally committed to attend Illinois in the fall of 2017. After the firing of John Groce, Pickett asked for and received a release of his letter of intent to Illinois. On November 17, 2016, five-star recruit Jeremiah Tilmon announced that he had signed his letter of intent with Illinois the  previous day, after a week of press uncertainty. However, after the coaching change at Illinois, Tilmon requested and received a release of his letter of intent with the school.

Roster

Schedule and results

|-
!colspan=12 style="background:#; color:#;"| Exhibition

|-
!colspan=12 style="background:#; color:#;"| Non-conference regular season

|-
!colspan=12 style="background:#; color:#;"| Big Ten regular season

|-
!colspan=12 style="background:#; color:#;"| Big Ten Tournament

|-
!colspan=12 style="background:#; color:#;"| NIT

References

Illinois
Category:Illinois Fighting Illini men's basketball seasons
Illinois
Illinois Fighting Illini men's b
Illinois Fighting Illini men's b


0, -i = -3*q + 5*p. Is q prime?
True
Let n = 25827 + -13868. Is n a composite number?
False
Suppose 5*d - 362998 = -2*n, -2*n + d = -436946 + 73948. Is n a composite number?
False
Suppose -4 = -4*r, -67 = -5*x + 5*r - 17. Let w(c) = 429*c**2 - 64*c + 12. Is w(x) prime?
True
Let t be (-5561)/(-6) - -2*(-1)/(-12). SuppState v. Carson, 21 Wn. App. 318, 322, 584 P.2d 990 (1978). Although the belief that defendant kept weapons is supported by police testimony at the omnibus hearing that Holloway told them defendant kept a gun by his bed,[2] police had no prior information that defendant had a known propensity to use the gun in resistance other than a general belief that a convicted felon may have such a propensity. Defendant, however, had no prior convictions for acts of violence or violence against law enforcement officers in particular.[3]
We hold that the State did not present sufficient evidence of exigent circumstances to justify the no knock entry of police. Accordingly, the contraband and other objects seized pursuant to the search of defendant's residence must be suppressed, requiring reversal of


outputs in console - two identical objects. Am I doing it wrong?

A:

I'm not sure why your code isn't working. But even if it would work, it is going to be less than ideal: you're downloading all data and then remove the outdated data on the client. This means that you're downloading data that your users won't see, which is wasteful.
I'd recommend to instead filter the data on the server, as shown in the AngularFire2 documentation:
return this.afDb.list('articles', {
  query: {
    orderByChild: 'validUntil',
    startAt: '2017-09-29T21:00:00.000Z'
  }
});

is not only good for people, but ultimately helps protect the wildlife of Colombia.

1 Comment

1

Wendy on April 11th, 2013 at 10:15 am

Love cotton top tamarins. The NYC Central Park zoo has a great exhibit. I can see how they would be appealing for pets. But yes wildlife should remain wild and free. I’m glad to see Disney give back globally and educate these kids about what kind of animal a pet should be and how to treat them. Good on Disney and UF vet school!

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Thanks for visiting the Disney Parks Blog. We welcome your comments. Please understand that this is a moderated blog. Blog comments will be reviewed prior to posting. As a result, there will be a delay in the posting of comments. Not all


substance of the allegations of his petition is that he has served his sentence and is entitled to release.  The petition was dismissed without a hearing.

2
On July 15, 1963, the United States Board of Parole released McKinney on parole.  He was immediately delivered to the state authorities of North Carolina on a detainer lodged by that state with the warden of the United States Penitentiary at Atlanta, Georgia.  The record does not show the disposition which North Carolina made of the charges against petitioner, but sometime thereafter he was taken into custody as a parole violator.  He is now confined in the United States Penitentiary at Leavenworth, Kansas, where he is serving the remainder of his sentence.

3
The trial court thought that the petition raisedThe long wait, or: Why we hate baseball

http://www.NewsAndOpinion.com |
It should have been the most hopeful, happiest evening of the year here in little ol' Little Rock. It was certainly one of the most awaited:

Opening Night of the Arkansas Travellers' 2005 season at Ray Winder Field!

(Add crowd noise and an organ playing "Take me out to the ball game . . . .")

New baseball fields have to strive for the retro look that makes parks like Camden Yards in Baltimore so fashionable. But here at Ray Winder, retro comes naturally; the little ballfield goes back to 1932.

Nostalgia is inherent in a pastoral game like baseball, even if it's being played in the middle of the Bronx or on Chicago's South Side. Ray Winder is coated with nostalgia from its


sure it would match more than once.  The currently uncommented solution doesn't work because the second part seems to operate on one letter at a time rather than each match like I expected, so it just removes the stuff in curly braces.  Worse, it removes everything between the outer braces in the PYTHON_ONLY_THING, which is no good.
I figure I need to change both my regex and Ruby code if this is going to work, but I'm not sure where to look for more help.  Or perhaps gsub isn't the right tool for this job.  Any ideas?
I am using Ruby 2.3.7 on Linux x86_64.

A:

Use String#gsub with an initial hash for replacements:
my_config.map do |k, v|
  [
    k,
    v.gsub(/(?<={)[^}]+(?=})/, my_config).gsub(/{(?!})|(?<!{)}/,measuring 3.1--4 cm and Ex positivity. However, for other subsets, p-MND did not help to prevent lymph node recurrence.

MND can induce various complications such as Horner syndrome, chyle leakage, and injury of the jugular vein and vagus nerve \[[@CR9]\], although these are uncommon events in p-MND cases. In addition, thyroid surgery patients who undergo MND experience neck pain, discomfort, and stiffness more often and more strongly than those who do not undergo MND, although rehabilitation can reduce these symptoms to some extent \[[@CR10]\]. We thus conclude that p-MND should not be routinely recommended for N0 and N1a patients with PTCs ≤4 cm, and we propose that the indications for p-MND should remain very limited.

Several limitations of the present study bear mention. This was not a prospective study, and the decision


---
abstract: 'We report a multiplanetary system found from the analysis of microlensing event OGLE-2018-BLG-1011, for which the light curve exhibits a double-bump anomaly around the peak. We find that the anomaly cannot be fully explained by the binary-lens or binary-source interpretations and its description requires the introduction of an additional lens component. The 3L1S (3 lens components and a single source) modeling yields three sets of solutions, in which one set of solutions indicates that the lens is a planetary system in a binary, while the other two sets imply that the lens is a multiplanetary system. By investigating the fits of the individual models to the detailed light curve structure, we find that the multiple-planet solution with planet-to-host mass ratios $\sim 9.5\times 10^{-3}$ and $\sim 15\times 10^{-3}$minima in the distribution of $\Delta\chi^2$ on the $s$–$q$ plane. For the individual local solutions, we gradually narrow down the ranges of the parameter space in the grid search. Besides these lensing parameters, a basic 2L1S modeling requires additional parameters, including the time of the closest lens-source approach, $t_0$, the lens-source separation at that time, $u_0$ (normalized to ${\theta_{\rm E}}$), the Einstein timescale, $t_{\rm E}$, and the source trajectory angle with respect to the binary-lens axis, $\alpha$. In the case when the source crosses the caustic formed by the binary lens, the lensing light curve is affected by finite-source effects and one needs an additional parameter of $\rho$, which represents the source radius $\theta_*$ normalized to ${\theta_{\rm E}}$, i.e., $\rho=\theta_*/{\theta_{\rm E}}$, to account for these effects. (MCMC) method.


the models (presented in the lower two panels). We note that the individual solutions are further refined based on the local minima obtained from the grid search by allowing all lensing parameters, including $s$ and $q$, to vary. In Table \[table:two\], we compare the $\chi^2$ values of the four 2L1S solutions. In Table \[table:three\], we list the best-fit lensing parameters of the individual 2L1S solutions. We also note that the model light curves corresponding to the close and wide solutions of each of the binary and planetary solution pairs are similar to each other and thus in Figure \[fig:five\] we present the one yielding a better fit to the data. In Figure \[fig:six\], we present the lens-system configurations, which represent the source trajectory with respect to the caustic, of the binary (upperhave to let you go on that answer alone." "Where'd you learn all that shit?" "I'm majoring in history." "Majoring in history?" "That's a fucking coincidence, isn't it, eh?" "But I am a man of my word, and either way, you know," "I did say 10... (MUTTERING)" "Here we go." "Okay." "MICK:" "Mmm." "Rightio." "In what year did the British start deporting convicts to Australia?" "The first 11 ships of the First Fleet arrived with their cargo of around 780 British convicts in Botany Bay, New South Wales." "And a further two convict fleets arrived in 1790 and 1791." "The first free settlers arrived in 1793." "Mick?" "Mick?" "That's right." "Isn't it?" "I know it is." "Why?" "Um..." "I'm not really sure I understand the question." "Why did


the British deport convicts to Australia?" "Why?" "Um..." "Uh..." "Come on, you dumb fuck." "Time waits for no man." " No, no, no!" " Tick, took, tick, took, tick..." "First, first..." "First of all, after the British lost the 13 colonies they'd lost their penal settlements in Virginia, in the United States." "And they needed somewhere to put all the criminals that were stacking up in England." "There were..." "There were just too many of these people, and they were just spreading disease and wasting resources." "And, second of all, they..." "And just, Australia looked to be as rich in resources as the Americas." "And obviously the British wanted to settle this before the French did." "Or the Dutch. (COUGHS)" "Something like that?" "Mick, no." "What the fuck,keep Australia beautiful!" "Fuck!" "(PANTING)" "We're having such a good time." "Singing, and drinking, and carrying on." "(SINGING) Tie me kangaroo down, sport" "Tie me kangaroo down Tie me..." " Ah, fuck ya!" " (GROWLING)" "Come on!" "Come on!" "Get out of here!" "Get him!" "Go on, get away up there." "Get on him!" "(CHUCKLING)" "(SNARLING)" "No!" "Come on, mate." "Where do you think you're going?" "I told ya, there's no way out of here." "(CHUCKLING)" "Fee-fi-fo-fum" "I smell the blood of a stinkin' Porn!" "Bit rough, ain't it?" "(GASPS)" "Now, where were we?" "Yeah, that's right." "You see, in this world, there's people like me and there's people like you." "And people like me eat people like you for breakfast and shit 'em out." "(CHOKING)" "You're nothing


Everybody’s a pay driver on the rungs up the ladder to F1.” ($1 = 0.7510 euros)

Roger Federer eyes London goldWorld number three Roger Federer has set his sights on winning Olympic gold at next year's London games.
The 30-year-old Swiss triumphed in the English capital yesterday by winning the ATP...

Dungo takes indefinite leavePHILIPPINE Volleyball Federation (PVF) President Generoso Dungo has formally filed an indefinite leave to primarily concentrate on his business and other personal interests.
PVF Secretary-...Best Marketing Articles

Friday, June 14, 2013

A CPA (Cost Per Action) system is a system of promoters that will pay you a percentage to promote for them. The client doesn't actually have to buy something, they just want them to take a particular activity. It can be the activity of providing their e-mail and other private details, or it can be deciding upon up for a test. If the prospective client uses your website with your online weblink to finish the activity, you will generate a percentage.

CPA promotion can be very profitable if done properly. To be able to begin making profits with CPA you must get approved to at least 1 CPA system. Through this system is where you will get the provides and online hyperlinks to promote


          22 (75.9%)                   27 (93.1%)                    118 (92.2%)
  **Initial Mean CD4 (cells/uL) (SD)**      379.26 (298.66)      371.22 (294.02)          415.03 (321.45)              332.29 (276.05)               389.38 (303.36)
  **Nadir Mean CD4 (cells/uL) (SD)**       delay free recall test trial. A single dependent variable was obtained for the total words recalled across the five immediate free recall test trials and the delay free recall trial.

Executive control/ working memory {#sec015}
---------------------------------

### SENAS Letter Fluency Test \[[@pone.0163772.ref027]\] {#sec016}

On this test participants were given 60s to generate words that begin with the letters 'F' and 'L' excluding proper nouns. The dependent variable was the total words recalled.

### SENAS Semantic Fluency Test \[[@pone.0163772.ref027]\] {#sec017}

On this test participants were given 60s to generate the names of animals. The dependent variable was the total number of correct responses.

### SENAS Working Memory Index \[[@pone.0163772.ref027]\] {#sec018}

The SENAS Working Memory Index includes four tasks: 1) Digit Span Backwards- participants are read a series of numbers to repeat in reverse order; 2) Visual Span


ranging from zero to five as follows: T scores \>40 = 0 (no impairment); T score 35--39 = 1; T score 30--34 = 2; T score 25--29 = 3; T score 20--24 = 4; T score \< 19 = 5 (severe impairment). Transformed scores were averaged into a total GDS, with higher scores reflecting greater overall impairment \[[@pone.0163772.ref031]\].

Statistical Analyses {#sec020}
--------------------

In addition to the calculation of the GDS, the nine neuropsychological variables were reduced to three neuropsychological composite scores (psychomotor speed/dexterity; declarative memory; working memory/executive control), l debased on the results of a PCA (see [results](#sec021){ref-type="sec"} section). The three neuropsychological composites were analyzed in conjunction with mitochondrial haplogroup to assess relationship to neuropsychological functioning. Initial haplogroup analysis used the R package, SNPRelate to perform a PCA on the mitochondrial       0.847                    0.168                        0.343

Specific sub-haplogroups are listed with a breakdown including number of patients of each sub-haplogroup and the p-values for all Mann-Whitney U segregation comparisons for the three neuropsychological composite scores derived from the PCA analysis as well as p-values for comparisons with GDS (Global Deficit Score), shown in blue text. Total number of patients listed is less than total number of patients in [Table 1](#pone.0163772.t001){ref-type="table"} due to missing neurocognitive values. Sub-haplogroups, which contain fewer than 5% of the


psychomotor speed and dexterity as identified in the larger cohort, although in this case the association between L3e and psychomotor speed and dexterity was not significant following correction for multiple comparisons ([S2 Fig](#pone.0163772.s002){ref-type="supplementary-material"}, Table A, B and C in [S2 File](#pone.0163772.s004){ref-type="supplementary-material"}, and [S2 Table](#pone.0163772.s006){ref-type="supplementary-material"}).

Discussion {#sec031}
==========

Mitochondrial haplogroups are thought to represent functionally distinct evolutionarily selected populations. Multiple studies have demonstrated a complex interaction between the mitochondrial genome and disease progression, suggesting that mitochondrial genetics can alter disease course \[[@pone.0163772.ref015], [@pone.0163772.ref038]\]. The results of our PCA analysis were consistent with the known evolutionary divergence of the L haplogroups. For example, L0 patient samples, which represent the oldest mitochondrial haplogroup arising \~128.2ka \[[@pone.0163772.ref033], [@pone.0163772.ref035]\], grouped separately in the PCA analysis from the remainder of the patient sample. Similarly, the L1 samples,Differential sensitivities of the sphincter of Oddi and gallbladder to cholecystokinin in the guinea pig: their role in transsphincteric bile flow.
Cholecystokinin (CCK) is considered to simply contract the gallbladder and relax the sphincter of Oddi with meals. In this study, we examined this hypothesis by investigating the action of CCK on the sphincter of Oddi and gallbladder of the guinea pig. The experimental design used an in vitro preparation of the sphincter of Oddi to measure contraction of the circular muscle. CCK increased tone in both the gallbladder and the sphincter of Oddi in a concentration-dependent manner. The normalized concentration-response curves for CCK, however, revealed that the gallbladder had a greater sensitivity to CCK (ED50 7 nM) than the sphincter of Oddi (ED50 22 nM; p < 0.01).


the cyclin D2^−/−^ mice when compared with their wild-type littermates. The cyclin D2^−/−^ mice were significantly smaller throughout the brain compared with WT mice (left); however, there was a stronger effect seen in both the cortex and the hippocampus (right), with a greater than 24% decrease in size for both structures. (**B--D**), Bar graphs highlighting the significant differences in absolute volume (mm^3^) found for total brain, hippocampal and DG volume. No significant differences were found in brain volumes between mice which have finished Morris water maze testing (MWM) versus swim stress (SS). Error bars represent 95% confidence intervals.

Acquisition and long-term memory in the MWM {#Sec5}
-------------------------------------------

To understand the influence of dentate neurogenesis on hippocampal-dependent spatial memory, we examined the cyclin D2^−/−^ mice using a tailored battery of behavioral testscyclin D2^−/−^ mice had robust deficits in the establishment of long-term memory starting at 24 hours following acquisition training.Figure 4Dentate neurogenesis adjusted for differences in hippocampal volume moderately correlates with time spent in the target quadrant 24 hours after Morris water maze acquisition learning. (**A**) A weak correlation was found between the number of DCX^+^ cells normalized to hippocampal volume and time spent in target quadrant 3 hours after acquisition. (**B**) A moderate correlation (r = 0.32113, F~(1,18)~ = 2.07, p = 0.1674) between DCX^+^ cell count adjusted for hippocampal volume and time spent in target quadrant was seen 24 hours after acquisition. (**C--F**) the correlation between DCX^+^ cell count adjusted for hippocampal volume was weaker at later time points and averaged over all timepoints.Figure 5Cyclin D2^−/−^ mice are able to learn a visual discrimination task. (**A**) The touchscreen


offspring were genotyped using Transnetyx (Cordova, TN, USA) with primers for cyclin D2^+/+^ (WT)  and cyclin D2^−/−^ shown in Table [2](#Tab2){ref-type="table"}. Dams produced up to 6 litters before being retired. If a pair did not produce offspring following 2 months of mating, they were given new partners or euthanized if too old (over 12 months of age). We used age- and sex-matched littermates as controls for this behavioral genetic study as previously described^[@CR45],[@CR46]^.Table 2Primer sequences used for genotyping of WT and cyclin D2^−/−^.GenotypeForward PrimerReporter 1Reverse PrimerWTAAGGTTCTGCAGCTCTCTTTTACAAAGGTGTGCAAACCACGCAGGCCCAGGCAATGCyclin D2^−/−^GCCCTCGAGCTCTGTACATGTCCGCGGTCGGTAGTTTGGGTTTTTTGCAGGAAGTTAGGAT

Experimental design {#Sec11}
-------------------

All animals were cared for in accordance with the guidelines and procedures set by the National Institutes of Health and the Institutional Animal Care and Use Committee at the University of California Davis (Sacramento, CA, USA). Animals were housed 2-4 percage in a temperature and humidity-controlled vivarium with a 12-hour light/dark cycle and provided food and water ad libitum. Cohort 1 was tested in the Morris water maze and open field assays starting at 6 weeks of age. In the Morris water maze, there were four subgroups: WT (water maze trained and probed; N = 20; 14 female and 6 male); WT (swim stress control; N = 15; 8 female and 7 males); cyclin D2^−/−^ (swim stress control; N = 15; 6 female and 9 male); cyclin D2^−/−^ (water maze trained and probed; N = 27; 13 female and 14 male). Swim stress was used as a control to ensure that physical exercise did not lead to changes in brain volumes on magnetic resonance (MR) imaging. A second cohort (Cohort 2) was later tested to replicate


\conn S^3_0(K)$. The connected sum formula [@oz:hf-properties] implies that $\HF^\circ(Y, {\mathfrak s}_0)$ is shown in Figure \[fig:hyp\], where $\alpha$ is a generator of $H_1(S^1 \times S^2)$ and $\beta$ is a generator of $H_1(S^3_0(K))$. (That is, the generators of $\HFi(Y, {\mathfrak s}_0)$ are named just as in the previous example, but now $\pi_*(Ua)$ and $\pi_*(Ub)$ are nontrivial.) We compute the $d$ invariants of $Y$.

First, if $H = H_1^T(Y)$, then $\KK^H \HFi(Y, {\mathfrak s}_0) = \QK^H \HFi(Y, {\mathfrak s}_0)$ is generated by $\{U^i d \mid i \in {\mathbb Z}\}$; $\KK^H \HFp(Y, {\mathfrak s}_0)$ is generated by $\{U^i d \mid i \le -1\} \cup \{U b\}$; and $J^+(Y, {\mathfrak s}_0, H) = \QQ (J^+(Y, {\mathfrak s}_0,H))$ is generated by $\{U^i d \mid i \le -1\}$.[^2] Thus, $$\dbot(Y, {\mathfrak s}_0) = d(Y,adapt the proof of [@oz:boundary Proposition 4.2]. By interchanging the roles of $Y$ and $-Y$, it suffices to prove the first statement. Furthermore, by Lemma \[lemma:samerank\], we may assume that $V$ is a primitive subspace. Let $k = \operatorname{rank}V$ and $b = b_1(Y)$.

As in [@oz:boundary], we denote the Heegaard Floer cohomology groups of $(-Y,{\mathfrak s})$ by $\HF_-(-Y,{\mathfrak s})$, $\HF_\infty(-Y,{\mathfrak s})$, and $\HF_+(-Y,{\mathfrak s})$, indicating the absolute grading with a superscript. Note that the action of $H_1^T(Y)$ on Heegaard Floer cohomology increases grading by $1$. There are duality isomorphisms $\DD^-$, $\DD^\infty$, $\DD^+$, which fit into a commutative diagram whose rows are exact: $$\xymatrix{
\cdots \ar[r]^-{\delta} & \HFm_m(Y,{\mathfrak s}) \ar[r]^{\iota_*} \ar[d]^{\DD^-}_{\cong} & \HFi_m (Y,{\mathfrak s}) \ar[r]^{\pi_*} \ar[d]^{\DD^\infty}_{\cong} & \HFp_m(Y,{\mathfrak s}) \ar[r]^-{\delta} \ar[d]^{\DD^+}_{\cong} & \cdots
  \\
\cdots \ar[r]^-{\delta^*} & \HF_+^{-m-2}(-Y,{\mathfrak s}) \ar[r]^{\pi^*}


A similar argument using $\KQ^{V \oplus W}$ in place of $\QK^{V \oplus W}$ shows that $$d^*(Y \conn Z, {\mathfrak s}\conn {\mathfrak t}, V \oplus W) \ge d^*(Y, {\mathfrak s}, V) + d^*(Z, {\mathfrak t}, W).$$ Applying the same reasoning to $-(Y \conn Z) = (-Y) \conn (-W)$, we see that $$d(-(Y \conn Z), {\mathfrak s}\conn {\mathfrak t}, V \oplus W) \ge d(-Y, {\mathfrak s}, V) + d(-Z, {\mathfrak t}, W)$$ and $$d^*(-Y \conn Z, {\mathfrak s}\conn {\mathfrak t}, V \oplus W) \ge d^*(-Y, {\mathfrak s}, V) + d^*(-Z, {\mathfrak t}, W).$$ The desired result then follows from Proposition \[prop:duality\].

Just as with rational homology spheres, the key property of the generalized correction terms is their behavior with respect to negative-definite cobordisms, given by a mild generalization of the resultsT_1(W')$ in such a way that $A$ is isomorphic to $\ker j'_*: T_1(Y') \to H_1(W')$. Moreover, the linking forms of $Y$ and $Y'$ are isomorphic. By the (usual) result for $n=0$, $A$ is a metabolizer as claimed.

Assembling these results, we obtain the main theorem of this section, which was well known in the case of knots [@jabuka-naik:dcover].

\[T:link-d\] Suppose $L \subset S^3$ is smoothly slice. Then there is a subgroup $A \subset T_1(\Sigma(L))$ that is a metabolizer for the linking form $$\lambda:  T_1(\Sigma(L)) \otimes  T_1(\Sigma(L)) \to {\mathbb Q}/{\mathbb Z}$$ such that for any  structure ${\mathfrak s}_t = {\mathfrak s}_o + t$ with $t \in A$, we have $\dbot(\Sigma(L), {\mathfrak s}_t) = -n/2$ and $\dtop(\Sigma(L), {\mathfrak s}_t) = n/2$, and hence $$d(\Sigma(L),{\mathfrak s},V) = \frac{n}{2} - \operatorname{rank}(V) \quad


over AT&T's disregard for net neutrality. Feedback also floods in from miffed subscribers with grandfathered unlimited plans. "As an AT&T customer, I am tired of you limiting what I do," says Mike from Chicago. "I pay you money every month to have these features. If I didnt have unlimited data, I would have dropped you guys so fast." Joseph from Miami is far more blunt, saying "you are liars and theives!" Predictably, many contributors are promising to jump ship to a rival carrier when their contracts expire. You won't find any words of praise for Ma Bell as part of this particular effort, but if you've been searching for a crowdsourced list of everything wrong with AT&T in its current state, look no further.alive, the Unicorn Horn weapon will drop.

Painter is filled with Newgrounds' jokes and references, such as one of his paintings being a "Carrot Clock" (TheClockCrew).

Out of all characters in the game, Painter has the most dialogue. The dialogue speech used is a text-to-speech voice called "Boing".

"I'm in your castle."

"I will paint you into a corner."

"My brush is mightier than your sword."

"My art will be your demise."

"Abort!"

"Help!"

"It must have been something I ate."

When the chest drops on Painter, it will have his hat on the top.

The Music playing while you battle Painter is The Show by Waterflame.

Painter might be a possible reference to Paint Roller of Kirby's Adventure, Adeline of Kirby and the Crystal Shards, or Drawcia from Kirby Canvas Curse, as they all use paintings to try to


Then again, some folks see charm and challenge in that short roster of lakes and those restrictive seasons. And they especially take pride in pursuing a fish others ignore. Two such anglers are Nick Hutchinson of Racine, and Howard “Hobby” Jackson, 18, who runs his North Woods Outdoor Guide Service from the family’s resort – Jackson’s Lakeside Cottages – on Little St. Germain Lake.

Jackson, who also answers to “Haji” when working nights at a nearby restaurant, agreed to let me tag along Aug. 3 when he and Hutchinson went jigging for lakers. Jackson took up laker fishing as a personal challenge two or three years ago, rather than joining the crowds of walleye, bass and muskie fisherman.

“I like those fish, too, but everyone’s after them,” he said. “VeryDear friends!

Do you like stories about secret rooms, hidden maps, the secret signs, clues and ancient treasures?

Ok. I'll tell you such a story.

Once upon a time a famous architect lived in LEGO city. He was fabulously rich and famous. But he had left a very strange testament after his death.

The old architect's testament says architect hid all his gold and jewels. He gave the map and the key to the treasure to Admiral Von Bricker, his friend.

It seems that everything is simple. But the admiral died 10 years before the architect wrote his testament. Therefore, it was impossible to ask the Admiral, where is the architect's treasure hidden?

People say that the treasure has not been found yet.

Maybe you can find them, good luck!

Yes. This is not an ordinary


Q:

Mark is moving when image Drag(Pan & Move)

I have a custom imageView with zoom using SeekBar. In that imageView I am Marking a portion of the image but when i move the image that mark is not moving with the image it remains same. So please help me , how to make that mark at the selected portion.
Following code I have Used To zoom:
public class ImageZoomView extends View implements Observer {

    /** Paint object used when drawing bitmap. */
    private final Paint mPaint = new Paint(Paint.FILTER_BITMAP_FLAG);

    /** Rectangle used (and re-used) for cropping source image. */
    private final Rect mRectSrc = new Rect();

    /** Rectangle used (and re-used) for specifying drawing area onLaunched in April 2016, the Ujjwala Yojna aimed to provide 5 crore free gas connections by April 2019.

One of the widely acclaimed initiatives by the Narendra Modi government — Pradhan Mantri Ujjwala Yojana (PMUY) –, which provides poor families partially-free LPG gas connection, has beaten its target by eight months. Launched in April 2016, the scheme aimed to provide 5 crore free gas connections by April 2019. However, the government will complete the target on Friday, eight months ahead of the target, TOI reported.

The Ujjwala Connection No. 5 crore is likely to be handed over to the beneficiary in the Parliament on Friday by Speaker Sumitra Mahajan, the newspaper reported. Ujjwala Yojna was launched to provide clean cooking gas connection to 5 crore families identified Socio Economic Caste


Wednesday, June 1, 2011

The best music festival in the NW (in my humble opinion) is Portland, Oregon's Musicfest NW. Not only is the locale desireable but the people in charge of booking the fest have impeccible taste -- taking chances on genres of music that most festivals only touch upon or disregard all together. Yes, they have the big named indie rock bands "headline" some large scale show in the middle of the city, but while the sheep are baaing at Band of Horses this year, some amazing bands will be blowing minds in various venues around the city. Here are the BIG highlights (aka SRG recommendations), and see the entire line-up HERE:a lot of people who are willing to spend a lot of money for their cat’s nutrition. This is one of the products that you may like to purchase for your cat. Get to know more about this product right now.

This is the wet cat food that you would like to get if you want something that will be effective in eliminating the hairballs that your cat may have. This contains omega-E that your cat would need to have healthy hair and skin. This cat food is also easy to digest. It will not cause digestive problems with your cat.

Major Features: This comes with key nutrients your cat may need.

This comes with key nutrients your cat may need. This is made with high-quality ingredients.

This is made with high-quality


Q:

Rotating a string using C++

Possible Duplicate:
Rotate a string in c++?
How to rotate a std::string?

I am making a application in c++ that works with Command line input. I am entering a string in to the command line
    int main(int argc, char** argv)
    {
        if(argc != 2)
        {
             cerr << "Invalid number of CMD arguments" << endl;
             return 1;
        }

        string StringValue = argv[1];
       maybe. Some kind of joy because he could no longer harm children? Perhaps. But what I felt instead was anger bordering on rage.

I was angry that nobody told me he passed away. I was angry that he never faced jail time or true judicial consequences of any sort for what he did to me. I was angry that he continued to work in churches around children as a leader, as a pastor, long after he pled guilty and walked off with a misdemeanor. I was angry he wasn’t on any of the sex offender registries. And sure, I was angry for everything he did to me. But most of all? I was angry he never once apologized.

Someone recently asked me if I believe in forgiveness for those that


website which can bring you thousands of addicting games over the world? No. doubt! ABCya.games is created for you. Just one click, you can explore the game world in your hands. Are you ready to put your name on the Leaderboard of any games? Let’s play at ABCya Games.some patients, and encouraging preliminary results were obtained with dehydroepiandrosterone. We strongly recommend estrogen replacement therapy to prevent postmenopausal osteoporosis in women with rheumatoid arthritis. Younger women with rheumatoid arthritis can undergo pregnancy or use estrogen-containing contraceptives. Estrogens can be used in lupus only with great caution. Recommendations regarding other hormones and other diseases are less firm, but research is continuing in this area.


   host_name_list = []

        for host in hosts:
            try:
                if host.has_key("source_host"):
                    host["host"] = host["source_host"]
                host_name_list.append(host["host"])
                bean = JmxReader(host["host"], host["port"], host["https"]) \
                    .read_query("/jmx?qry=Hadoop:service=HBase,name=Master,sub=Server&anonymous=true") \
  not bool(hosts):
            logging.warn("Non hosts are configured as 'resourcemanager' in 'input' config, exit")
            return

        logging.info("Checking resource manager HA: " + str(hosts))

        active_count = 0
        standby_count = 0
        failed_count = 0

        failed_host_list = []

        for host in hosts:
            try:
                cluster_info


   self.collect({
            "host": all_hosts_name,
            "component": "resourcemanager",
            "metric": "hadoop.resourcemanager.hastate.total.count",
            "value": total_count
        })

        self.collect({
            "host": all_hosts_name,
            "component": "resourcemanager",
            "metric": "hadoop.resourcemanager.hastate.active.count",
            "value": active_count
    Valerie Jarrett, senior adviser to President Obama, is asked if there was guidance from the White House to Cabinet secretaries including Clinton not to use private email accounts. “Yes, there were. Yeah, absolutely. […] Obviously, we want to make sure that we preserve all government records, and so there was guidance given that government business should be done on government emails and that if you did use a private email that it should be turned over.” (C-SPAN, 9/30/2015)

Clinton has been a private citizen since 2013, but it is standard procedure for high-ranking officials to keep their clearances after leaving office. However, McClatchy Newspapers comments, “While Clinton has kept her clearance, it’s common practice to suspend them while an investigation or internal inquiry is ongoing, according to some national


planners finally decided on a route that would travel west along Wilshire Blvd. to Fairfax Avenue, then turn north along Fairfax to the San Fernando Valley. Following a methane explosion in 1985 at a Ross Dress for Less clothing store near Fairfax and Third Street, Congressman Henry Waxman worked to legally designate a large part of Mid-Wilshire as a "methane zone". This zone stretched on either side of Wilshire Boulevard from Hancock Park to west of Fairfax (through areas of his district where subway opposition was strongest). Congress passed the ban in 1986. Subsequently, any plans for a subway west of Western Avenue diverted the line south around the methane zone, using Crenshaw, Pico, and San Vicente Boulevards, but these plans never came to fruition.

The passage of theHollywood Bowl stop was determined not to have enough year-round ridership to meet FTA formulas for Federal funding, just one of the reasons for not building a station there). The FTA approved the all subway route and funding (although broken into 2 phases rather than the original 1 phase in order to spread the cost over time making it more likely to be approved by Congress as part of the Federal Budget) for the line as it exists today.

Building awareness to the new Metro Red Line required a massive public relations and advertising campaign. Several agencies were awarded contracts to supply information, create signage and billboards, and produce radio, newspaper and television advertising. Coronado Communications, in alliance with sub-contractor Pangea Corporation, worked out a creative strategy to communicate


and tunnels took more time to resolve than the actual construction.[14]

During construction, 2,000 fossils were discovered, including 64 extinct species of fish, the tusk of an Ice Ageelephant and the bones of an ancient longhorn bison, a report funded by the MTA found. The report was authored by paleontologist Bruce Lander of Paleo Environmental Associates in Irvine. Lander worked with a team of 28 scientists during construction of the Metro Rail Red Line. Fossil evidence showed that tens of thousands of years ago, ground sloths, horses, elephants and camels roamed among redwood trees in what is now Los Angeles, according to an MTA summary of the 300-page report. The scientists also found evidence of a great flood in the San Fernando Valley 9,000 years ago that swept awayher indelible right to counsel attached
in September 2005, thus requiring a hearing (see generally People v
Frazier, 87 AD3d 1350, 1351). We therefore reverse the order in
appeal No. 2 and remit the matter to County Court to determine
defendant’s motion following a hearing on that issue (see generally
id.; People v Liggins, 56 AD3d 1265, 1266).

     Finally, contrary to defendant’s further contention in appeal No.
2, she was not deprived of meaningful representation based upon
defense counsel’s failure to seek suppression of the September 7, 2007
statement on the additional ground that her indelible right to counsel
had attached. That single error does not constitute a sufficiently
egregious error in an otherwise competent performance so as to deny
defendant a fair trial (see People v Cummings, 16 NY3d 784, 785, cert
denied ___ US___,


many other nations (ranging from Australia to Chile to the Faroe Islands) that have implemented this type of reform.

Given all the other types of government spending across the Atlantic, Social Security reform surely won’t be a sufficient condition to save Europe, but it surely is a necessary condition.

Here’s my video explaining why such reform is a good idea, both in America and every other place in the world.     address 14270 Strathmoor, Detroit . . .

       Affiant respectfully requests the court order this affidavit is not made public until
       needed in the prosecution of a criminal case. The affiant has reasons to believe that
       DPD-1 and DPD-2 and their family members would be in danger of retaliation by the
       release of this affidavit because their identities are know [sic] by HEARN.

       The Search Warrant Tabulation and Return listed that the police recovered three weapons,

including a .357 revolver, as well as two cell phones, miscellaneous papers, and clothing from 14270

Strathmoor.


                        B.

        Johnson asserts that the fact that the informants came forward only in response to the reward

Murad’s family offered casts doubt on their veracity, credibility and reliability. He contends that this

is particularly true given that the initial contact with the woman, who turned out to be DPD-1’s

girlfriend, involved an apparent scam because she asked to be paid half the reward money before

providing information related to Murad’s shooting. Johnson argues that had the warrant affidavit

set forth this information, it would have undercut any finding of the informants’ veracity, credibility

and reliability.

        We            14
No. 11-1817
United States v. Herman Johnson

truth is a fact question. United States v. Rice, 478 F.3d 704, 709 (6th Cir. 2007); see also United

States v. Bennett, 905 F.2d 931, 934 (6th Cir.1990) (reviewing this determination for clear error).

                                                  B.

       The district court did not clearly err in finding that the affidavit’s references to the alleged

shooter as “Zachary Hearn, Jr.,” (as opposed


client name with
new TerminalServicesManager().CurrentSession.ClientName

Another SO thread shows how to retrieve the current session's client name or the client names of all sessions.

A:

On the client, use:
string machineName = Environment.MachineName;

or they can bedramatized, i.e., converted into dramas and staged or made into screenplays for film or television. As a literary form, genre, and structure, dramaenactslife, representing it not once removed, as in narration, but directly in the here-and-now, through various dramatis personae acting, emoting, speaking, and gesturing in dramaticscenes. Both drama genres, tragedy and comedy, portray character, misfortune, trauma, and suffering but in different styles: the former is serious and melancholy, e.g., Shakespeare’sHamlet,the latter humorous and farcical, e.g., Molière’sThe Imaginary Invalid.I discussed the importance of comic and humor elsewhere (Lothane, 2008).

Biblical and Homeric stories were chanted or recited to audiences, Greek and Roman dramas were staged in amphitheaters. With the invention of printing, stories became novels and novellas read by solitary readers. The reader’s relation to the


In real life people are neither walking novels nor actors: they are agents in life’s everyday dramas. The psychoanalytic situation is a stage defined by itsframewhere the participants are not merely narrators, dreamers, daydreamers, free-associators, and interpreters, but also concretely, not metaphorically, enactors of the roles of patient and therapist, in reality and transference. Loewald (1975) wrote: “Language—speech—because of its central role in human action, is a dominant element in drama … Language is not merely a means of reporting action, it is itself action … In the course of the psychoanalytic process, narrative is drawn into the context of transference dramatization, into the force-field of re-enactment. … [T]he patient … is speaking from the depth of his memories, which regain life and poignancy by the impetus andsensations and hallucinations and other peculiar enactments. On the psychological continuum between her pre-morbid state and her illness “she embellished her life in a manner which probably influenced her decisively in the direction of her illness, by indulging in systematic day-dreaming, which she described as her ‘private theatre’, … living through fairy tales in her imagination, … [which] passed over into illness without a break” (p. 32).

Returning to Vienna after a brief absence Breuer “found the patient much worse. She had gone entirely without food the whole time, was full of anxiety and her hallucinatoryabsences[French] were filled with terrifying figures, death’s heads and skeletons” (Breuer & Freud, 1895, p. 26). Furthermore, notes Breuer, “da sie diese Dinge durchlebend, sie teilweise sprechendtragierte“ (Breuer & Freud, 1909, p. 20; my


(1900b) utilized such dramatizations when he transformed Breuer’s cathartic method into his own psychoanalytic method in the first paragraph ofThe Interpretation of Dreams: a “psychological technique which makes it possible to interpret dreams as meaningful psychic formations which, at the appropriate place, can be inserted into the mental activities of waking life” (p. 1, my translation) (Freud, 1900a, pp. 100-104).

Dramatology in Freud: dramatization in dream and in fantasy

Already defined by Aristotle as thoughts of those that sleep, dreams become an interpersonal experience when told to another person. Dreams (and day dreams) represent ideas and emotions in mental pictures, or images, which Freud called “representability” and “dramatization.” While asleep with eyes shut, we vividly ‘see,’ i.e., hallucinate, dream scenarios, in white and black and in color: “Dreams … thinktime social psychology as well” (Freud, 1921, p. 69), with dramatological implications.

Writing to Fliess in 1897 Freud (1950) underscored the affinity between daydreams, myths, and “dramas of destiny”: “falling in love with the mother and jealousy of the father …I now regard … as a universal event of early childhood … ofOedipus Rex… Each member of the audience was once, in germ and in phantasy, just such an Oedipus. … the same thing may … lie at the bottom ofHamletas well” (p. 265). Freud (1916-1917) revisited Sophocles two decades later: “many people have dreamt of lying with their mothers … [the spectator] reacts as though by self-analysis he had recognized the Oedipus complex in himself (pp. 330-331). … Rank [The Incest Motif in Poetry and Saga, 1912] has


the nature of the facts which form the material of psychoanalysis that we are obliged to pay as much attention in our case histories to the purely human and social circumstances of our patients as to the somatic data and the symptoms of the disorder. Above all, our interest will be directed towards their family circumstances…” (p. 18). Hysteria becomes family drama, technique is tailored to the individual.

In therapy, a real life situation, the Aristotelian unity of action, place, and time is both literal and real, not just a theatrical convention. Also real, not metaphorical, were Dora’s dramatic duels with Freud, as reality and as the theater of transference. Dora, “a girl of intelligent and engaging looks” (p. 23) and “sharp-sighted” (p. 34) fires “arguments,” “rejoinders” “objections” andshould have confronted her less with seducing Herr K. at age fourteen and more with not dating a boy her age at eighteen. Dora dramatized her conflict with Freud, as other women before her; but here confrontation, contest (agon), and combat occupied center stage: she acted and acted out. Hence the new conception of analysis as a transference drama played out between two protagonists turned antagonists, in which “this latest creation of the disease must becombatedlike the earlier ones. This happens, however, to be by far the hardest part of the whole task. It is easy to learn how to interpret dreams, to extract from the patient’s associations his unconscious thoughts and memories, and topractice similar explanatory arts: for these the patient will always provide the text” (1905,


of living among one’s own kind, the problem of the survival of the family. Psychoanalytic theory … has also examined various formulations and “solutions” to the same problematic” (p. 253).

Modell (1990), echoing Bleger, underscored the “psychoanalytic setting as a frame” (p. 30) in which “reality set-off and demarcated from ordinary life,… paradoxical in that the essence of play [is] its freedom and spontaneity, but it is a freedom that must occur within certain constraints,” or “restraints,”, i.e., “restrained by the ‘rules of the game’” (p. 27). He also cited Winnicott: “psychotherapy takes place in the overlap between two areas of playing, that of the patient and that of the therapist” (p. 29), thus closer to action.

Loewald (1975) addressed the “fantasy character of the psychoanalytic situation … a re-enactment,following dialogue ensued:

T(herapist): I see you spilled coffee on the sofa and stained it.

P(atient): (agitated) No, I did not!

T: I saw you cleaning.

P: (sheepishly) Well, I guess I did.

T: (calmly) Come in and let us discuss it further.

After he settled down on the couch:

P: Spilling the coffee was a mistake, I did not do it on purpose.

T: However, you damaged something of mine and you owe for the cleaning.

P: (more agitated). No f…ing way! It's a piece of junk anyway, and I already pay you thousands of dollars a year, and you don't even give your patients a nice waiting room. If you had more room out there, I wouldn't have bumped the coffee. You really don't care about your patients with that decrepit, crappy old waiting room.


that he had always prevented me from touching as a child and which caused me great rage.”

Subsequently “the scene resurfaced in many vivid dreams I started having the night the incident happened and the weeks that followed. I had dreams about mangling myself, other objects, fears of losing control, not unlike the old fears of going crazy. Here is an example of a particularly scary dream. I was walking down a deserted street only to be set upon by members of a violent gang. By investigating this dream that arose in direct proximity to the sofa incident, I began to gain insight into my own anger that I had, for most of my life, framed as a continual state of victimhood where others, like the gang that triedand reciprocal enactment with the analyst, both conscious and unconscious.

Political drama happens in real life and it can be staged as social drama, both progressing from confrontation, an actual clash between dramatis personae as agents, passing to climax and to resolution. Freud confronted Dora, Jacobs (1986) “confronted” his patient, I confronted mine. Greenson (1967) defined: “At least four distinct procedures are included or subsumed under the heading of “analyzing”:confrontation, clarification, interpretation,andworking through” (p. 97). Quoting Reich (1928) on character defenses and resistances, Greenson recommended that “the resistance must be demonstrable and the patient must be confronted with it. Then the particular or precise detail of the resistance has to be placed into sharp focus.Confrontationandclarificationare necessary adjuncts to interpretation and have been recognized as such ever since our knowledge


exciting and intense, or powerfully expressive. From the perspective of the psychoanalytic method and work, dramatic and dramatology mean live dialogue in the here and now. I argue for the primacy of dramatology for the psychoanalytic situation. Dramatology represents a new challenge to the psychoanalytic method. Given this living reality, the aliveness of interaction, dramatology confronts the deadness of psychiatric descriptive phenomenology (à la Kraepelin and Jaspers), psychiatric diagnoses (DSM-IV, ICD-10), and dynamic formulas (Freud, Jung and other schools). This may seem a radical stance and it is. I do not deny, however, the legitimacy of description, diagnosis, or dynamics, only underscore the fact that that description, diagnosis and dynamics address different activities and goals as compared to dramatology. Freud offered the following recommendation:

It is not a goodmen do mew their hawks, / And make her gently come unto the lure." Back at Alfonso's home, Aurelius and Valeria have found a merchant to impersonate Aurelius's wealthy father. At Ferando's, Sander taunts Kate with talk of food. Aurelius brings his pretend father to meet Alfonso and to promise to give Aurelius lands and property, which Alfonso matches with an increased dowry. A haberdasher brings a cap to Kate, but Ferando sends away the man and the cap; a tailor arrives with a gown, but, after being denigrated by Ferando, it is sent away; Ferando tells Kate they will go to her father's, but only when Kate allows Ferando to declare the time of day to be whatever he chooses. Alfonso's two younger daughters and their lovers


like?" "Lines and lines of pigeons in the pictures all going... (yawns)" "Pigeons have saved many lives as carriers in wars," " right up even until the Second World War." " So we're rewarding them with a cinema?" "We're rewarding ourselves by researching into all kinds of interesting pigeon-related data." "When they sit in and the Pathe News chicken comes up, do they go, "Bah"?" " For example, I could tell you..." " "Crap eyes!"" "...it costs 105,000 pounds last year, to clean up the pigeon crap" " from Trafalgar Square." " St Mark's Square." "Well, that's..." "St Mark's Square, I think you're probably right, from Trafalgar Square." "Where do pigeons get that sort of money?" "When you're driving down the road, why does the pigeon not jumpon a picnic, so if you got spinach or stuff stuck in your teeth, if you grab a pigeon and shove it to your face, like that, it's gonna suck it out for you," "so it avoids gum disease and I think it would be very useful." "I want to tell you that the real answer is even more disgusting than that." "It is repellant." "You don't even use the front end of a pigeon." "This is, I have to say, I think it's a practice that has died out, but it was common right up until a couple of hundred years ago." "What are the dangers on a picnic, for example?" " Bees." " Bees, wasps, or even worse..." "Ants." "Bad company." " Snakes." " A snake."


in 2001, after he admitted going more than 100 miles an hour on the M1, and was fined ?" "200." "In the three previous years, he earned nine points on his licence for speeding." "And the best reason he could come up with was that he didn't want his constituents to catch cold waiting for him." "Now, "Three Buggy" Grant received a speeding ticket while driving his horse and buggy in Washington DC in 1869." "He had to persuade the officer in charge that he was guilty and he was fined ?" "20." "God, was that a speed camera, like a bloke, you know, with a big black hood over him?" ""No, now hold it, now, wait a minute." "In 30 minutes, I'll have this."" "No, it wasa sketch artist." "There's something very odd also that they both have in common, they've both won extraordinary prizes." "Ulysses S Grant, as a boy, won a prize for taming a pony in a circus." "But the prize that Prescott won, very odd... 1951, in Brighton," " the Prescott family won second prize..." " (Alan) Knobbly knees?" "The most typical family in Britain competition." "Absolutely true." " (Bill) But second?" " Yeah, but second." "But should have been first, because the winning family was found out to be distantly related to the organiser of the competition." "So there was corruption, but not on the part of John Prescott, but there you are." "It's time to grapple with the unknown, the unknowable and the never known." " (Bill) What?"


friend Martin's Uncle Roy?" "He's huge." " Is it in the sea?" " Mammoth." "I'll tell you what it is, it's the honey mushroom," " of which the largest recorded specimen is..." " Bigger than a redwood tree?" "Yes." "The largest specimen is in the Malheur National Forest in Oregon." "It covers 2,200 acres, ladies and gentlemen." " One mushroom?" " It is between 2 and 8,000 years old." "It was initially thought to grow in separate clusters, but researchers have now confirmed the discovery that it is one single huge organism connected under the soil." "Who was the first man to claim that the Earth goes round the sun?" "(bagpipes)" " Copernicus?" " (alarm bells)" "Oh, no, oh, no!" "Oh, no!" "Oh, dear, oh, dear." " Not,tell you." "Antonio Meucci, Italian-born scientist." "He invented the telephone." "He had perfected it by 1871, couldn't afford the patent." "But do you know what happened?" "It was being assessed for a patent in the offices of Western Union, it fell into the hands of a young Scottish engineer called Alexander Graham Bell." " (Scottish accent) "Aye, I'm nicking that!"" " Boo." "And he grabbed the chance and patented it in his own name." "Meucci took him to court, but died before the judgement was given, leaving Bell to claim his place in history." "What do we say to Alexander Graham Bell?" " You (bleep)" " Boo!" "(Stephen) Isn't that wicked?" "Isn't it as wicked as you get?" "Isn't that..." "It's wicked." "That's what we'd have said in


the preparation of such states and provide a new route for studying quantum theory with massive objects; in particular, in combination with quantum-optical control techniques. These devices allow for studying the collective center-of-mass motion of massive objects that span the size range from hundreds of nanometers in the case of nano electromechanical or nano optomechanical systems (NEMS/NOMS) to tens of centimeters in the case of gravitational wave antennae. The quickly developing field of quantum optomechanics [@Schwab2005a; @Kippenberg2008a; @Aspelmeyer2010a] opens - aside from numerous novel sensing and actuation technologies at and beyond the quantum limit - a unique opportunity to generate superposition states of massive objects, thereby revealing new opportunities for macroscopic quantum experiments.

DECIDE uses the techniques of quantum optomechanics to realize quantum states with objects on a macroscopicwhich is designed for low thermal conductivity. More detailed analysis for the optimal concept is required.

### Protective shield cover and bake-out

The surface area of the shield (all layers) is approximately 1${\rm m^2}$. For a first conservative estimate, we assume a specific density of ${\rm \rho_{Al}\approx 2.7g/cm^3}$ (aluminum) and a thickness of 1 mm with a mass of ${\rm m\approx3~kg}$. Using a chemically inert and minimally outgassing refractory metal for the innermost shield, e.g. Niobium with ${\rm \rho_{Nb}=9~g/cm^3}$, would increase the mass to $\approx4$ kg. The hollow struts are made from CFRP of very low thermal conductivity and expansion as well as good mechanical stability. They are 40 cm long, 2 cm in diameter and have a wall thickness of 1.6 mm, giving a combined mass of less than


= 330\,W}$ if we bake-out at 400 K. Providing 100 to 150 W for that purpose during commissioning phase while many units are inactive would - as an example - pose no problem for LPF resources.

### Single-mode fibers at cryogenic temperatures

From previous studies [@Flatscher2011] we find that single-mode glass fibers can in principle be operated at temperatures as low as 10 K without structural damage to the core. The study described in [@Flatscher2011] deals with the design, manufacturing, and extensive testing of single-mode waveguides in the mid-infrared for a typical Darwin [@Leger2007] application. The environmental tests comprised a vacuum test at ambient temperature, a cryogenic test at 10 K, proton radiation test, and gamma radiation tests. All performance tests were done at CO-laser wavelength of 5.6 micron andat the outgassing of a small surface element of area $A_{out}$. The two scenarios are depicted in Figure \[figure\_outgassing\_geometry\]a and b, respectively.

![Outgassing from a sphere (a) and a quadratic surface element (b). In both cases the density of the outgassed molecules scales inversely proportional to the square distance.[]{data-label="figure_outgassing_geometry"}](figure_outgassing_geometry.pdf){width="1.0\linewidth"}

The particle density $n$ at a distance $x_s$ from the center of the outgassing sphere and at a distance $x_d$ from the center of a surface element are given by equation \[equation\_density\_sphere\] (left) and (right), respectively. Here we assumed that the distance between the outgassing surface element and the measurement sphere is much larger than the width of the surface element. $$\label{equation_density_sphere}
    n(x_s)=n_0\frac{R_s^2}{x_s^2}=\frac{\gamma_0}{v_{rms}}\frac{R_s^2}{x_s^2} \hspace{2cm}
    n(x_d)\approx n_0\frac{A_{out}}{4x_d^2}2=n_0\frac{A_{out}}{x_d^2}\frac{1}{2}$$ Based on equation \[equation\_density\_sphere\] we find that for a


on the order of $10^{-8}\,\mathrm{N/\sqrt{Hz}}$. If we assume the spacecraft to have a mass of $2000\,$kg, this results in an acceleration noise of $5\times 10^{-10} \mathrm{m s^{-2}/\sqrt{Hz}}$. Over a time of $10\,$s, this leads to a position inaccuracy of less than $40\,$pm. That means, our original proposal would have required a significantly better thruster system than LISA.

However, as we have described earlier, new results show that we need $t_2\gg t_1$ for an interference pattern to form. To violate all macrorealistic models considered here, one needs a total free-fall time of $t_{tot} = t_1+t_2\approx 200\,$s. For these parameters, the fringe spacing is $20-40\,$nm. Given state-of-the-art micro thrusters as discussed above, the position inaccuracy over $t_{tot}$ is less than $1\,$nm. This should allow to clearly resolve the interference pattern.

For themechanical frequencies (GHz), we expect that similar results will soon be achievable for mechanical systems with lower mechanical frequencies [@Groeblacher2009a; @Riviere2011a]. However, while feedback cooling of optically trapped dielectric spheres has been demonstrated [@Ashkin1977a; @Li2011a], cavity cooling and, in particular, cooling to the ground state of motion has yet to be shown.

-   **Cavities in space**:\
    The proposed mission requires a cavity with a high finesse of $> 10000$. So far, such high-finesse cavities have not been demonstrated in space missions but several proposed missions rely on this technique because high-finesse cavities are promising candidates for high-precision frequency standards (see, e.g., [@Jiang2011a]). We are confident that the ongoing development [@Folkner2010a] effort will soon provide feasible venues for a technological realization of this central element


with lower absorption coefficients at $1064\,$nm is therefore essential.

-   **Influence of magnetic fields and charging**:\
    This will have to be studied in detail in the future and will be addressed by an ESA study performed by some of the authors [@Kaltenbaek2012a].

-   **Gravitational field of the spacecraft**:\
    Because of the very long free expansion times [@Kaltenbaek2012a], the gravitational attraction of the nanosphere towards the spacecraft is critical. Compensating masses on the platform of DECIDE may solve this issue but further studies are necessary.

-   **Transverse expansion of the wavefunction**:\
    While the position of the nanosphere transverse to the cavity mode is not critical in itself, one has to assure that the particle does not leavespheres can be cooled using feed-back cooling [@Li2011a]. Several groups are attempting to achieve the ground-state of motion for this type of mechanical system. We are confident that this necessary prerequisite for DECIDE will soon be achieved.

Case for space {#subsec::CaseForSpace}
--------------

In the following, we will give a series of arguments that require the proposed experiments to be performed in space.

### CASE

In CASE, microspheres are optically trapped, and the shift of their center-of-mass position due to accelerations is measured. The field trapping the microsphere necessarily has to be weak in order to achieve high sensitivity and to reduce the effect of heating of the center-of-mass motion by the trapping laser. Such a weak field can only trap the microsphere in a micro-gravity environment. Micro gravity can, in principle, be achieved


von Humboldt foundation, and M. A. acknowledges funding by the Austrian Science Fund FWF (START, FOQUS), the European Research Council (ERC StG QOM), and the European Commission (FP7 STREP MINOS, Q-ESSENCE).

[^1]: While, here, we have used the notion of post-selection of cases where no UV light is scattered, it can be shown that no post-selection is necessary for an interference pattern to form [@Kaltenbaek2012a].

[^2]: As we have described in section \[sub::DECcomp\], this is oversimplified. A more detailed analysis will be given in a separate study [@Kaltenbaek2012a].
employees’ workplace experience. There are several unique programs that cater to the demographics of all employees. These programs are integrated with the direction in which the organization is headed currently and involve quite a high degree of personal and human connects.

“A real honor! Sixth in 2017, third in 2018, and first in 2019—we continue to raise the bar on what it means to be a Great Place To Work. I strongly believe that there is a direct correlation between our culture and our business’ success. Once we, as a team, believe that we are a Great Workplace, we see the entire organization functioning at an altogether higher level of efficiency and quality. My personal approach to making a Great Workplace is to clearly communicate this purpose in creating


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About SAS R&D India

SAS R&D India (Pvt.) Ltd., a wholly owned subsidiary of SAS Inc., USA, is a key development center for research and development of products and solutions for SAS. The Pune office, being the largest R&D center outside the U.S., is focused on developing strategic products and solutions of SAS.

About SAS

SAS is the leader in analytics. Through innovative software and services, SAS empowers and inspires customers around the world to transform data into intelligence. SAS gives you THE POWERreference to recently released documents about Clinton's work on those deals as Secretary of State after she had previously pledged to oppose them during her 2008 presidential campaign. "Hillary's careful wording on TPP in her primary battle — that she now disapproves of it only 'in its current form' after months of lobbying for it — is further proof that she has every intention of ramming it down the throats of the American people, sending millions more jobs overseas. Hillary is the outsourcing candidate."


Patent Publication of Unexamined Application. The prior art liquid crystal display panel is hereinbelow referred to as xe2x80x9cthird prior artxe2x80x9d.
The third prior art comprises a liquid crystal display panel 31 sandwiched between polarizing plates 32a and 32b, and an optical diffusion plate 33 is attached to the polarizing plate 32b. A light source (not shown) is provided at the back of the polarizing plate 32a, and illuminates the liquid crystal display panel 31 through the polarizing plate 32a. The light is incident onto the liquid crystal display panel 31, and carries an image from the liquid crystal display panel 31 through the polarizing plate 32b to the optical diffusion plate 33. The optical diffusion plate 33 diffuses the image carrying light, and averages the contrast ratio over theimage forming screen due to the averaging of the contrast over the image forming screen, and whitens the image due to the irregular reflection. Moreover, the optical diffusion plate reflects the light from the outside thereof, and makes the visibility poor.
It is therefore an important object of the present invention to provide a liquid crystal display panel which improves the viewing angle and is prevented from the inversion of gradation, the unintentionally colored image and poor visibility.
To accomplish the object, the present invention proposes to compensate the anisotropy of refractive index of liquid crystal and diffuse image carrying light after the optical compensation.
In accordance with the present invention, there is provided a liquid crystal display unit comprising: a light source generating first light proceeding along an optical path;


by Terry Acton to Accept, second by John Scherrer, all ayes M/C.

Ordinance: Rod Williams Citations are up....The condemned mobile home on Cranberry lake rd., is scheduled to be torn down on 7-2-15. Some others are also being scheduled for the same.

Unfinished Business:

Harrison District Library: Resolution 14-26 read by Maye Rood.

The Amendment to the

Hayes township hereby approve the

Roll Call: Motion by John Scherrer, supp. Maye Rood

Maye rood, Lee Dancer, John Scherrer, Nancy Austin, Terry Acton.

Heintz Propane Contract...no need to renew. Bldg. will be either sold or for the winter.

JBS contract was approved earlier.

Cemetery Foundations: Motion by Terry Acton to increase the cost of foundations to .25 per inch, 2nd by John Scherrer, all in favor, M/C.

Waste Management: Terry Acton made motion to

The large disposable carts from Waste Management willI’m telling you: you could have had that blessing a lot sooner.

Use the talents God gave you. Now. You don’t have to wait until after college and make one of your gifts a career. People have started to tell you that you have a great singing voice. You’ve even sung solos. Enjoy those times. Work at getting even better.

hsdiploma.com

You’ve known you wanted to be a teacher since you were four. What about helping out with the nursery class at Sunday school? Or, here’s a daring thought. What if you offered babysitting services to the unwed mother down block? Teen moms must be even lonelier than you.

You know how you enjoy writing? Surprise! You publish several magazine articles during years when you’re not teaching. And after you retire? You


really happened, the details are so specifically human and universal, they fascinate us. But if the details of what happened aren’t given to us in specific ways, the human aspects become lost or uninteresting. How storytellers assemble the details of a story is called narration. What are some of the ways we judge a narration to be good or bad?

if the details of what happened aren’t given to us in specific ways….we become lost or uninterested.

There is of course in all stories the beginning, middle, and end/conclusion. That type linear reality in real life isn’t always so clear cut. But in a story, without a clear linear progression of time the narrative its hard for an audience to process. Really good storytellers lead an audience through the elementsof four steps. First, differentially expressed mRNA isoforms (DEIs) are extracted by comparing abnormal cells and controls using RNA-seq analysis tools [@pone.0079118-Trapnell1]. These DEIs that may experience abnormal splicing are putative targets of splicing factors that might function abnormally in disease. Assuming that co-expressed genes have a good probability of being functionally related, we clustered these DEIs to co-expressed groups using hierarchical clustering method. These co-expressed isoforms may be regulated by the same group of transcription factors (TFs) and splicing factors (SFs). Since co-expressed mRNAs are more likely to have their promoter regions bound by common transcription factors, we constructed a dataset called promoter region dataset (PRD) to mine the TF-isoform interactions (for example, co-expressed isoforms may also have common splicing factors that bind to the regions near


interaction strength between a SF and an isoform, , where, is the conservation score of -th binding site between -th isoform and-th splicing factor; is the interaction strength between -th splicing factor and -th isoform; is the number of binding sites. Some factors, especially the hnRNP family, are due to alternative splicing, for example hnRNP H1, hnRNP H2 and hnRNP H3, which means they may have similar structure [@pone.0079118-Lorkovic1],motifs [@pone.0079118-Piva2] and binding profiles. After we computed their interaction strength with isoforms according to our definition, the correlation between interaction strength vectors were high. To increase the robustness of our linear regression model, we averaged the binding strength and obtained four new factors, called hnRNP A1/A2 (average of hnRNP A1 and A2), hnRNP H1/H2/H3(average of hnRNP H1, H2 and                                        DAZ associated protein 1.
  **ETR-3**             CUGBP2                                      CUG triplet repeat RNA binding protein 2. ETR-3 induces exon 5 inclusion in cTNT gene (PMID: 11931771), induces exon 9 inclusion in CFTR gene (PMID: 15657417), promotes selectively the exclusion of Tau


associated with hematological disease, including the MTOR gene which is in the Akt/mTOR pathway and is critical for cell survival and proliferation in high-risk MDS patients [@pone.0079118-Follo1]. Since the Akt/mTOR has been advised as a therapeutic target for treating MDS, our study suggested that its abnormality might be related with the splicing switch of SRSF11.

Supporting Information {#s5}
======================

######

**RT-PCR.** A portable document format (pdf) file contains details of RT-PCR.

(PDF)

######

Click here for additional data file.

[^1]: **Competing Interests:**The authors have declared that no competing interests exist.

[^2]: Conceived and designed the experiments: CC XZ. Analyzed the data: HW. Wrote the paper: HW. Designed the model and algorithm: HW. Designed the experiments of next generation sequencing and PCR: JW. Participated in discussion and revision: CC XZ. Read and approved the final manuscript:Pours completely black, no amber glints even to speak of. The espresso colored compact head leaves several meandering trails of lace on the glass. In the nose, chocolate and black coffee mix with some citrus and alcohol. The taste is enormously malty and roasty with molasses, tobacco, coffee and cocoa flavors. A creeping alcohol heat is always evident. Citrus and pine hops are in the background, providing a good balance to the maltiness. The mouthfeel is medium bodied with a subtle, moderate carbonation. A moderate hop bitterness blends with chocolate, roasty and booze flavors in the long finish.

This is a good Imperial Stout. It could be a little fuller bodied and modest in alcohol flavor, but still definitely worth a try.

O/D - A fairly nice Imperial Stout and


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in math and English, students’ growth and progress, and the performance and growth of the bottom 25 percent of students. For high schools, graduation rates are another factor.

More than a dozen other states use similar grading systems. Maine intentionally kept the criteria simple, say Gov. Paul LePage and Education Commissioner Stephen Bowen.

“What this has already done is create a discussion across the entire state, and that’s not a bad thing,” LePage’s spokeswoman, Adrienne Bennett, said Thursday. “We welcome the discussion.”

Advocates say the system, backed up by a new comprehensive “data warehouse” on the Education Department’s website, provides transparency and gives parents a snapshot of how their children’s schools are doing.

Critics say a single letter grade doesn’t capture the totality of a school’s work and community.

“There’s a saying that‘simplicity is the enemy of fairness.’ This strikes me as one of those situations,” said David Silvernail, director of the Center for Educational Policy, Applied Research and Evaluation at the University of Southern Maine. “We know there is a relationship (between poverty and lower test scores) there. It’s been well established. This grading system, unfortunately, just highlights it.”

He said a system that included socioeconomic data and expenditures would give a clearer picture of a school’s performance.

Grading schools A to F is “an extremely blunt and crude way to approach such a complicated topic,” said Donald Hernandez, a demographer and sociology professor at Hunter College of City University of New York.

Families who live in poverty are more likely to live in neighborhoods with lower-performing schools, he said. Those schoolchildren


cells examined ([Figure 1B](#pone-0050023-g001){ref-type="fig"} and [Table 1](#pone-0050023-t001){ref-type="table"}).

The WICH complex localizes to the Xi {#s3b}
------------------------------------

Prior research indicates that WSTF participates in several different complexes [@pone.0050023-Barnett1]. Thus, we sought to determine what context WSTF can be seen in when enrichment is observed at the Xi. Towards this goal, we performed immunostaining on hTERT-RPE1 cells using antibodies raised against WSTF and subunits of the various WSTF-containing complexes. We used BRM for [W]{.ul}STF [I]{.ul}ncluding the [N]{.ul}ucleosome [A]{.ul}ssembly [C]{.ul}omplex (WINAC) [@pone.0050023-Yoshimura1] and SNF2H [@pone.0050023-Lazzaro1] for the WICH and B-WICH chromatin remodeling complexes [@pone.0050023-Bozhenok1], [@pone.0050023-Cavellan1].

In hTERT-RPE1 cells, the distribution of WSTF appeared distinct from BRM, and consistent with previous observations, BRM was deficient at the Xi [@pone.0050023-Chadwick3] even when WSTF was enriched ([Figure 2](#pone-0050023-g002){ref-type="fig"}, top row). In contrast, WSTF showed substantial overlap with SNF2Haddress this, we took two complementary approaches. First, we compared the enrichment of WICH to the distribution of histone H3 dimethylated at lysine 4 (H3K4me2) and H3 acetylated at lysine 9 (H3K9Ac). Nucleosomes of the Xi are hypoacetylated [@pone.0050023-Jeppesen1], [@pone.0050023-Boggs2] and underrepresented for H3K4me2 [@pone.0050023-Boggs1], which is consistent with the association of both modifications with euchromatin [@pone.0050023-Kouzarides1]. As such, by immunofluorescence the Xi appears as a distinct hole in the distribution, demarcating the territory of the chromosome [@pone.0050023-Boggs1], [@pone.0050023-Chadwick3]. Elevated levels of WICH at the Xi clearly reside within this hypo-H3K9Ac and hypo-H3K4me2 region ([Figure 9](#pone-0050023-g009){ref-type="fig"}). Next, we performed WSTF immunofluorescence combined with fluorescence *in situ* hybridization (FISH) with X-linked bacterial artificial chromosomes (BACs). Several BAC clones were selected that reside within bands of macroH2A.1/H3K27me3 or H3K9me3 ([Figure


contains Server Authentication OID among others.

Make sure this template allows the key to be exported and that the Subject Name is not built from Active Directory, but is marked to be supplied within the request.
Ensure that certificate template's Security allows Domain Controllers, Enterprise Domain Controllers, and Read Only Domain Controllers to both Read and Enroll.

Publish your newly created certificate template.
Logon to each domain controller, request a new certificate from your template, and set the following as the naming information (example is for dc1.domain.com):

Common Name: dc1.domain.com
SANs: dc1.domain.com, dc1, domain.com, and domain.

Restart each domain controller (not always required, but for good measure) and verify that Event Viewer's Security channel is no longer throwing Warnings about not finding a suitable certificate.

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How Can I Quickly Verify LDAPS Connectivity Internally?

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I'm scaling back my game plans due to cost.Even though we only live 3 hours from Lambeau and can drive down and back in a day, 2 tickets plus beer and food is approaching 4 bills, oh yeah, gotta throw gasin there.I'm cutting it to 1 game and only if I get get an early fall game.The Lions game this last year was the last winter game I will ever attend.

Care to explain why you won't be going back in the winter? I was


set in. Perhaps it's easier for the folks that actually live in Wisconsin, though.

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until this week. There is swan like stalks shooting out, with the bud lazily swaying and drooping...... almost like swan head. The stalks are long, about the right proportion of a swan neck. I am trying to imagine the look and the colour when the bud opens up....I visualize that the stalks will straighten up bringing along the flowers to face the sky. I am guessing the colour of the blooms to be deep reddish purple... Huh.

I don't know the name of the orchid. Is it really an orchid to begin with?...

Sunday, February 14, 2010

We went out to the centre of Putrajaya. The place is Putrajaya Square, overlooking the Prime Minister Office. Putrajaya Mosque was a little bit to the left. There was this nice looking telephone booth,particular, if any ${\textsf{L}}$-complete problem can be solved in $O(f(N))$ MPC rounds, so can all the other ${\textsf{L}}$-complete problems. In other words, either all ${\textsf{L}}$-complete problems can be solved in $O(f(N))$ MPC rounds, or none of them can.

We remark that in Theorem \[thm:L\] no assumption is placed on the function $f(N)$, which therefore can be of any form, even a constant. Hence, Theorem \[thm:L\] says that all the known ${\textsf{L}}$-complete problems such as graph connectivity, graph bipartiteness, cycle detection, and formula evaluation, are *equivalent* in the MPC model, and in a very strong sense: they all require asymptotically the same number of rounds. (Analogous equivalences are common in computer science, e.g., in the theory of ${\textsf{NP}}$-completeness and, at a finer-grained level, in the recent fine-grained complexity theory, where equivalence classes


we cannot rely on a reduction to negative triangle to prove equivalences to APSP or related hardness results: we need sublogarithmic fine-grained reductions.

Hence we shall follow a different path, by reducing from the shortest path problem. Given a weighted graph, two distinguished nodes $s$ and $t$, and an integer $k$, shortest path is the problem of determining if the distance of a shortest path from $s$ to $t$ is $k$. This problem is ${\textsf{NL}}$-complete, even for undirected and unweighted graphs [@BorodinCDRT89]. (This also explains why the repeated matrix squaring discussed in the previous paragraph is best possible under Conjecture \[cnj:NL\].) As we will show shortly, it turns out that shortest path is reducible in $O(1)$ MPC rounds to several fundamental graph problems, including many graph centrality problems defined in termsthe diameter when executed on graph $G'$ always returns $4nM$ plus the shortest-path distance between $s$ and $t$ in $G'$. By construction, the latter quantity, which we denote by $\alpha$, is at most $(n-1)M$ if $s$ and $t$ are connected in $G$, and (exactly) $2nM$ otherwise. Thus the answer to shortest path is $\alpha$ if the diameter of $G'$ is at most $4nM + (n-1)M$, and infinity otherwise.

In the directed case, we use the same weighted graph $G'$ as before, adding one parallel edge for each edge, both with the same weight but with opposite directions. The rest of the algorithm is the same and its analysis is analogous to the undirected case.

Observe that $st$-connectivity in undirected or directed graphs can also be reduced to diameter, with the