art, process art, anti-art art. Ana Mendieta rolled in mud.

Vito Acconci, now an architect, sat under a slanted gallery floor and masturbated for days on end. Chris Burden nailed himself to a Volkswagen, was shot in the arm, and shot at airplanes with real bullets. Not having been there, we learn about these new art forms from the leftover paraphernalia. Books and museums show us black and white photographs, gallery invites, artists’ statements and manifestos—all of minimal visual interest—and the putatively unrectangular event gets reduced, through a ruse of history, into that very familiar rectangle: the 8 1/2 by 11 sheet of copy paper in a course packet.

Minimalism and postminimalism agreed on one thing: eliminate pictures. Painting took to a pure territory, while the new art forms expandedshowed a sinus rhythm of 52 beats/minute, prolonged QU interval of 820 ms, prolonged PR interval of 22 ms, ST-segment depression, T-wave inversion, and U waves, which were best seen in the precordial leads (particularly in leads V2 and V4). The level of serum potassium gradually increased following oral and intravenous potassium supplementation of approximately 10 g/day. Two days later, stool emissions were reduced to five times per day. The level of serum potassium was 2.85 mmol/L and a simultaneous ECG examination showed sinus rhythm of 58 beats/minute, a prolonged QU interval of 720 ms, ST-segment depression, T wave inversion, and improvement of U waves ( Figure 2 ). After 5 days of potassium supplementation, potassium levels improved to normal levels and paralysis of the lower extremities gradually


often characterized by an intense allosteric dependence and dichotomous effects on extracellular potassium concentrations ([K+] o ), including the inward rectifier potassium channel (I K1 ), the rapid component of the delayed rectifier-like potassium channel (I Kr ), and the transient outward potassium current (I to ).19 Because of cytoplasmic magnesium and polyamines, the I K1 shows a dichotomous effect during hypokalemia. The I K1 has a paradoxical connection with [K+] o where the I K1 peak current density is decreased during hypokalemia.20 Even though hypokalemia hyperpolarizes the potassium equilibrium potential, the driving force of outward potassium flow is increased, and the increased blocking stability of cations in the pore results in decreased of conductance and outward potassium current. The mechanisms that regulate the conductance of potassium channelsJanuary 2, 2010 and her first Number One in the United States since "Somebody" in August 2004. It also debuted at number 96 on the Billboard Hot 100 on the week ending October 17, 2009 and peaked at number 38, becoming her 3rd top 40 hit on that chart. The song has become McEntire's longest-running number-one single with four weeks at number one on the Billboard Hot Country Songs chart.

Year-end charts

References

External links

Category:2009 singles
Category:Reba McEntire songs
Category:Music videos directed by Trey Fanjoy
Category:Songs written by Steve Diamond (songwriter)
Category:Songs written by Marv Green
Category:Billboard Hot Country Songs number-one singles
Category:Big Machine Records singles
Category:Song recordings produced by Mark Bright (record producer)
Category:2009 songs


and it is also given as neoadjuvant treatment \[[@R13]\]. However, some patients are insensitive to paclitaxel-based therapy and no biomarker is currently available to adequately identify patients that are less likely to be sensible to taxanes treatment, thus preventing unnecessary side effects.

The leucine zipper putative tumor suppressor 1 (LZTS1, previously named FEZ1) gene was identified as a tumor suppressor gene at 8p22 \[[@R14]\]. Lzts1 expression is ubiquitously detected in normal tissues, but it is frequently downregulated or absent in different human cancers \[[@R15]-[@R21]\], including breast cancer \[[@R22]\]. LZTS1 deficient mice develop cancers with diverse histogenetic backgrounds \[[@R23], [@R24]\], suggesting that LZTS1 acts as a major tumor suppressor gene in multiple cell types.

By the functional point of view, Lzts1 inhibits cancer cell growth through the regulation of the mitoticwas calculated using the Oncomine website ([www.oncomine.org](http://www.oncomine.org)). Box plots show differences in mRNA expression between normal breast, ductal carcinoma, and lobular carcinoma. Data are presented as box plot distribution (line= median value). Numbers represent samples analyzed. (B) Lzts1 immunohistochemical expression is downregulated in breast cancer. Lzts1 staining was significantly lower in cancer specimens than in normal breast samples (p \< 0.001). Numbers represent TMA samples available for the analysis. Black= % positive cases, white= % negative cases. (C) Representative images of Lzts1 immunostaining in the normal breast duct, and in two breast cancer specimens. (Original magnification, 200x) (D) Lzts1 immunohistochemical status is associated to tumor recurrence. Lzts1 staining was dichotomized (2+ vs 0/1+). Lzts1 positive cases showed a significantly lower incidence of tumor recurrence (p=0.031). Numbers represent TMA


  Ductal                   205 (76.0%)     40 (69.0%)   72 (76.6%)   93 (78.8%)
  Lobular                  20 (7.4%)       3 (5.2%)     8 (8.5%)     9 (7.6%)
  Mixed                    9 (3.3%)          124 (45.9%)     23 (39.7%)   41 (43.6%)   60 (50.8%)
  Missing data             8 (3.0%)        5 (8.6%)     2 (2.1%)     1 (0.8%)
  Death
  No


real time PCR (qRT-PCT) {#s4_7}
--------------------------------------------------------------

Total RNA was isolated using TRIZOL reagent solution (Invitrogen) and reverse-transcribed using random hexanucleotides as primers and MultiScribe reverse transcriptase (Applied Biosystem). Quantitative real time-PCR was performed with the SYBR Green PCR Master Mix (Applied Biosystems) under the following conditions: 10 min at 95 °C followed by 40 cycles (15 s at 95 °C and 1 min at 60 °C). Glucose-6-phosphate dehydrogenase (GAPDH) was included as housekeeping gene control to correct for equal RNA amounts. Primer sequences and respective probes were designed using the Universal ProbeLibrary (Roche) and the ProbeFinder software (<http://www.roche-applied-science.com/>): human LZTS1 forward 5\'-GAG CCT CAT GAA GGA GCA GG-3\', human LZTS1 reverse 5\'- CAG GTC CTG GGT CCT CAG CT 3\'. All the reactions were run in triplicate, including no-template controls.

Statisticalstring[] { "tag1", "tag2", "tag3" });

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Instead, the methane is likely to stay active in the Arctic for many years at its highest warming potential, due to depletion of hydroxyl and oxygen, while the resulting summer warming (when the sun doesn't set) is likely to keep triggering further releases in the Arctic.


leadership role from Intel.”

Lisa Su on stage at CES 2019 (Source: CTA)

Changing semiconductor landscape

Asked about the potential of an Intel-AMD merger, Krewell told us to “file it under fiction.” He noted, “It would give Intel complete dominance of PCs and servers and be considered anticompetitive.” Jon Peddie, President of Jon Peddie Research, also told us, “Not in a million trillion light years.”

Both noted that the U.S. Federal Trade Commission (FTC) would never allow it.

However, one CEO who teased the Intel-AMD deal begged to differ. “The semiconductor market today is no longer limited to CPUs for PCs,” he said. With Nvidia’s strength in GPUs for AIs and data centers, the Intel vs. AMD duo play is no longer monopolizing the market.

More importantly, given the rise of system vendors likewill likewise not alter the existing criminal trends in 2016.

In fact, before his recapture, organized crime-related violence in Sinaloa state suggested that internal conflicts were emerging within Sinaloa-based crime groups, including in Guzman's own criminal network. A firefight in December between rival gunmen in Badiraguato, Sinaloa state — the municipality where Guzman was raised — resulted in the deaths of eight people, one of whom was identified as a lieutenant for Guzman's brother, Aureliano Guzman Loera. Uncorroborated reports from Sinaloan media outlets say the conflict resulted from a familial dispute involving Guzman, though the information cannot be verified. Regardless, Guzman's freedom clearly has not slowed the internal divisions that continue to arise within Sinaloa-based organized crime.

Tamaulipas' Loss of Leadership

Los Zetas began 2015 with efforts to consolidate territory lost


throughout the year, including top leader Omar "Z-42" Trevino Morales in March. While many of the group's crime bosses captured during the first half of 2015 were based out of northeast Mexico (such as Trevino), federal troops later shifted their focus to Los Zetas crime bosses based farther south, particularly in Veracruz and Tabasco. In November, authorities in Queretaro captured Alejandro "El Picoreta" Castro Alfonso, a Los Zetas regional crime boss overseeing Los Zetas operations in Veracruz, Oaxaca, Puebla, Chiapas, and Campeche states.

Federal troops have also continued to pressure Los Zetas' parent organization, the Gulf cartel, with arrests. In April, authorities in Cancun captured Juan Daniel "El Talibancillo" Velazquez Caballero, one of the top leaders of the widest operating Gulf cartel group, the Velazquez network, and brother ofQ:

Check if a user account was activated by administrator

We have a Joomla system where users can self-activate their accounts. However some users have had problems with this (eg the activation email never arrived) and have had their accounts activated by the site administrators.
But is there any way to tell retrospectively which users were self activated and which were activated manually by admin? (and even better, by which admin user?)

A:

I have been able to resolve this question by writing my own plugin, as recommended by Lodder in the comments.
My plugin is very simple; it merely creates a user note against the user when the user's account is activated.
Activation can occur in three ways:

The user activates their account via the activation email.
The site admin activates the account manually via the


Meteor Crater Visitor Center

I-40 at exit 233 Winslow, , -- 86047

Meteor Crater Visitor Center

Visit the world’s best preserved meteorite impact site just minutes from Interstate 40 in Northern Arizona near Winslow. Meteor Crater is the breath-taking result of a collision between a piece of an asteroid traveling at 26,000 miles per hour and planet Earth approximately 50,000 years ago.

Today, Meteor Crater is nearly one mile across, 2.4 miles in circumference and more than 550 feet deep. It is an international tourist venue with outdoor observation trails, air conditioned indoor viewing, wide screen movie theater, interactive discovery center, unique gift and rock shop, and Astronaut Memorial Park at the modern Visitor Center located on the crater rim.

Meteor Crater's "Collisions And Impacts" movie, featuring exciting 3D modeling and animation allowsthe game to a 10–3 score in the 3rd quarter followed up by Maurice Jones-Drew running for a 3-yard touchdown to make the final score 17–3.

With the loss, the Colts entered their bye week at 0–10.

Week 12: vs. Carolina Panthers

After a good rest on their bye week, the Colts stayed home for a game against the Panthers. In the first quarter the Panthers jumped into an early lead as Olindo Mare kicked a 30-yard field goal for a leading score of 3–0.  They would make it 10–0 in the 2nd quarter when Cam Newton ran for a touchdown from 14 yards out.  The Colts got on the board when Donald Brown ran for a 17-yard touchdown coming within 3, 10–7.  Followed by an Adam Vinatieri


voltage falling below the threshold value. T.sub.ON is the duration when discharge current keeps flowing, while T.sub.OFF is the duration from the time power is turned off, to interrupt discharge current to the time power is turned on again.
The prior art described above has the following problems.
First, discharge machining having satisfactory reproducibility cannot be expected.
Although there are some formula to calculate the electrode feed Z.sub.n in accordance with the progress of discharge machining, the electrode feed Z.sub.n calculated from the formula does not warrant satisfactory reproducibility for discharge machining. The electrode feed Z.sub.n has heretofore been calculated by substituting in the following equation the data obtained by measuring in advance the machining gap value and the machined surface roughness value by changing any machining conditions among predetermined machiningAdblock is running! Adblocker plugins can interfere with the Adaptive streaming APIs. For an enjoyable experience add us to your Adblock tool as an Exception. Hide

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Write your own tunes, or use public domain tunes!

Build up a body of your own material and why not check out traditionals, hyms, and look up the definition of “public domain” tunes. This way no one can ever accuse you of copyright violation. Not easy but legal! Get started. I am amazed that people on Youtube learn my material.

God bless those of you like Andy McKee, Tommy Emmanuel, Don Ross and so on. You guys who have well loved original tunes. No one can ever take you down for your originals!

Step 2 – Create a Copyright-Infringement-Free youtube account if you are infringing (i.e. if you have any cover tunes you did not write) on your current account. I am in the process of launching a new youtube channelEucalypse

Eucalypse is an album by the Japanese noise musician Merzbow. The title is a combination of apocalypse and eucalyptus.

Masami Akita was made aware of the problems caused by Eucalyptus globulus trees in India by the label owner. Akita considers ecology and animal rights to be closely related.

The CD comes in a hand-crafted round wooden box with swiveling lid. It includes four round cards, and is a limited edition of 1,000 copies.

Track listing

Personnel
Masami Akita – EMS Synthi A, Roland Organ/Strings 09, handmade instruments, computer, effects

References

Category:Merzbow albums
Category:2008 albums


surprisingly large number of the illustrations have, however, been seen before, so either there is a lot less suitable previously unpublished material available, or some (a lot?) is being kept back for future release... My guess is that we are going to see numerous 'from the archives' books in the coming years.

'Elvis Day By Day' is excellently bound and printed. I must admit that I have not yet read the book thoroughly from cover to cover, but I get the impression that it is perhaps not quite as revolutionary as we had expected, as far as new photos and information are concerend. Nevertheless, it will make a nice addition to any Elvis book collection, big or small, and if you don't yet have any books about Elvis, thenHuman Interaction conference in Paris during May 2013. The details of the technology have been written up in a paper titled "ZoomBoard: A Diminutive QWERTY Soft Keyboard Using Iterative Zooming for Ultra-Small Devices".

According to Technology Review, the researchers do not plan to commercialize Zoomboard. Instead the source code, which is only about 100 lines, will be made available online for anyone to use.


All right folks, calm down.

Google’s latest social gig Google Plus is out and lots of people are jumping in right away. At this moment, Google Plus is available as invite only, we have some invitations to give away here.

Google plus is a new initiative from Google which aims to redefine how social sharing works. With Circles, Hangouts and lots of innovative features, Google plus is definitely here to stay.

Things To Know Before You Setup Your Google Plus Profile

Before you ask anyone for a Google plus invite, here are a few things you should know:

1. Google Plus works only with Google accounts that have an active Google profile. If you haven’t created your Google profile yet, you won’t be able to sign up for Google Plus.

2. Only regular Gmailchange with each iteration. Before the comma is str, after is next.
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string theory. In the analysis in [@NewBig] and in this paper, for specificity, we arbitrarily choose the “left-right” model. A similar analysis can be carried out for the “Pati-Salam”-like model. However, it was shown in [@Ovrut:2012wg] that this choice does not significantly influence the results. Finally, below $M_{I}$ the intermediate theory is spontaneously broken to precisely the B-L MSSM with the gauge group, spectrum and Lagrangian specified above.

In summary, our analysis encompasses five fundamental mass scales. From low to high energy these are: $M_{Z}<M_{Z_{R}}<M_{I}<M_{U}$ as well as $M_{SUSY} < M_{Z_{R}}$ or $M_{Z_{R}} \leq M_{SUSY}$. The gauge parameters of the theory will be analyzed as follows. First, the experimental values of the $SU(3)_{C}$, $SU(2)_{L}$ and hypercharge $U(1)_{Y}$ couplings at the electroweak scale $M_{Z}$ $$\label{eq:alpha.ew}
    \alpha_3(M_Z)=0.118,\ \alpha_2(M_Z)=0.0337,\ \alpha_Y(M_Z)=0.0102$$m\_[\_1\^]{} > 100 GeV  . \[bounds1\] Second, based on recent CMS and ATLAS studies of the R-parity conserving MSSM at the LHC, we can conservatively estimate that all squark and the gluino physical masses must satisfy [@CMS:2014ksa; @Aad:2014wea] m\_[q]{} > 1000 GeV, m\_[g]{} > 1300 GeV. \[bounds2\] We now search for all the purple points in Figure 2 that, in addition to breaking B-L and electroweak symmetry, also satisfy , and the other particle lower mass bounds. These points are shown in cyan in Figure 3. Our analysis reveals that these are $38.2 \%$ of the purple points and, therefore, $2.77 \%$ of the $10^{7}$ initial points in the “cloud”.

![This plot covers the same part of the $S_{BL}-S_{R}$ plane as the green/purple region of Figure 2. Now, however, any such point that


M_{Z_{R}}$, 2) the masses are considerable more spread out between approximately $800~GeV$ and $13~TeV$ and 3) the LSP is the lightest neutralino fermion.

![Two examples of physical sparticle spectra. (A) and (B) correspond to two different sets of initial soft masses associated with the black points ($(9.094)^{2} TeV^2$,$-(11.0)^{2} TeV^2$) and ($-(9.148)^{2} TeV^2$,$-(15.58)^{2} TeV^2$), respectively, in the $S_{BL}-S_{R}$ plane. Unlabeled mass levels correspond to heavier species of the sparticle type indicated on the lowest level. The scales $M_{Z}$, $M_{SUSY}$ and $M_{Z_{{R}}}$ are shown as solid, dashed and dot-dashed black lines respectively. Note that, in addition to sparticles, the mass levels of the Higgs scalars, labeled by $h^0$ and $H^0$, are shown on the left side of each plot. The $H^0$ mass level is degenerate and includes $A^0$ and $H^\pm$ asof low energy supersymmetric particle physics that, for a large space of input parameters, manages to satisfy present experimental bounds without excessive fine-tuning. The B-L MSSM makes explicit low energy predictions for particle physics phenomena–much of which is potentially observable at the LHC.\
[**Acknowledgments:**]{} B.A. Ovrut, A. Purves and S. Spinner are supported in part by the DOE under contract No. DE-SC0007901 and by the NSF under grant No. 1001296. S. Spinner would also like to thank P. Fileviez Perez for discussion and a long term collaboration on related topics.  \

[99]{}

S. Dimopoulos and H. Georgi, “Softly Broken Supersymmetry and SU(5),” Nucl. Phys. B [**193**]{}, 150 (1981). C. R. Nappi and B. A. Ovrut, “Supersymmetric Extension of the SU(3) x SU(2) x U(1) Model,” Phys. Lett. B [**113**]{}, 175 (1982). S. P. Martin, “A Supersymmetry primer,” Adv. Ser. Direct. High Energy Phys.  [**21**]{}, 1 (2010)


of any value to human beings.”

Just hours after Mr. Obama spoke, the White House revealed that the president had authorized a secret military mission this summer to a site in Syria in a bid to free Mr. Foley and other Americans held by the terrorist group, but the hostages were not there.

“The U.S. government had what we believed was sufficient intelligence, and when the opportunity presented itself, the president authorized the Department of Defense to move aggressively to recover our citizens,” said Lisa Monaco, assistant to the president for homeland security and counterterrorism. “Unfortunately, that mission was not successful because the hostages were not present.”

The White House did not reveal exactly when or where in Syria the mission took place. Citing administration sources, The Associated Press reported thatMost large predatory animals can, and will, see humans as suitable prey, under the right circumstances; however, true “man eaters”, that is, individual animals that prefer human flesh over any other food, are very rare. This list is a selection of some of the worst cases of man eaters recorded in history.

10 The lions of Njombe

We start this list with the worst case of man-eating lions in History. It was not a single man eater, but an entire pride that preferred human flesh over any other kind of food. It happened in 1932, in Tanzania near the town of Njombe. A large pride of lions went into a particularly brutal killing spree. Legend has it that the lions were being controlled by the witch doctor of a local


tribe, named Matamula Mangera, who sent them into rampage as revenge against his own people after being deposed of his post. The tribesmen were so terrified of the man-eating lions that they wouldn’t even dare speaking of them, believing that a simple mention would cause them to appear. They begged to the tribe chief to restore the witch doctor to his post, but he refused. The lions kept attacking and, eventually, took over 1,500 human lives (some say over 2000); the worst lion attack in History, and one of the worst cases of animal attacks ever recorded. Eventually, George Rushby, a famed hunter, decided to put an end to the attacks. He killed 15 lions, and the rest of the pride eventually abandoned the area, finally ending thedefend herself by throwing firewood at the beast, but was eventually dragged to the forest by the bear. When people arrived to the, now empty, house, they found the floor and walls covered on blood. Thirty men went to the forest, determined to kill the bear and recover the unfortunate woman’s remains. They found Kesagake and shot him again, but failed to kill him. The animal fled and they found the woman’s partially eaten body buried under the snow, where the bear had stored it for later consumption.

The bear later returned to the Ota family’s farm, and armed guards were sent after him. But this left another village house unprotected, and Kesagake took advantage of this, attacking the Miyoke family’s home and mauling everyone inside. Although some of


Introduction {#s1}
============

The identification of immune correlates and - moreover- the antigens that induce these protective responses is critical for effective vaccine development. In the post-genomic era, reverse vaccinology approaches, the rational selection of antigens from sequence data, are increasingly used to determine key immunological epitopes [@pone.0071610-Sette1]. However, immune correlates for many if not most infectious diseases including the knowledge of the antigenic targets of protective immunity are still unknown. Most vaccines currently in the clinic are based on purified, immunodominant antigens or attenuated or inactivated whole pathogens. Such vaccines typically require specialized manufacturing processes and cannot be easily adapted to newly emerging strains. In contrast, a rationally designed, recombinant vaccine based on a single antigen or a small number of antigens, representing several different serotypes, can be producedavailable. However, recently a second generation of epitope prediction methods have emerged that make use of new or improved prediction algorithms and expanded training sets. To evaluate these newer approaches, we carried out additional epitope predictions using the linear epitope prediction methods *BayesB* [@pone.0071610-Wee1], *CBTope* [@pone.0071610-Ansari1], and *COBEPro* [@pone.0071610-Sweredoski1], and the conformational epitope prediction methods *ElliPro* [@pone.0071610-Ponomarenko1], *EPSVR* [@pone.0071610-Liang1], *SEPPA* [@pone.0071610-Sun1], and *BEPro* [@pone.0071610-Sweredoski2].

T cell epitopes in *Pf*CelTOS that bind to MHC class I and class II epitopes for C57BL/6 and BALB/c mice were predicted using the *Rankpep* algorithm. *In silico* derived B and T cell epitopes were experimentally verified *in vivo* using *Pf*CelTOS-vaccinated rabbits and mice immune sera. Compilation of these data clearly identified several regions of the antigen harboring B cell epitopes as well as several


density, or OD) to serum antibodies. For simplicity, a given residue's score from the peptide-scan of mouse or rabbit antisera was defined as the maximum OD value observed for the set of overlapping peptides it was present in. OD value thresholds of 0.2 and 0.4 were used for mouse and rabbit anti-sera, respectively, above which a residue was classified as an epitope residue. These thresholds reflect OD measurements for CelTOS peptides representing the N-terminal signal sequence which was absent in the recombinant *Pf*CelTOS construct used for immunization and thus considered to be not antigen-specific.

Assessment of B cell Epitope Mapping Predictions {#s2l}
------------------------------------------------

Quantitatively comparing predicted and experimental epitope mapping results is critical for the proper assessment of their accuracy and significance. An adapted approach [@pone.0071610-Larsen1] was applied to calculate bothepitope Ia, a significant portion of epitope II, and the C-terminal epitope III were predicted as epitopes by all structure models. Interestingly, although there was significant divergence in the overall protein fold by the structure predictions, the local structure of the predicted B cell epitopes was remarkably consistent across predictions ([Figure 2](#pone-0071610-g002){ref-type="fig"}). Epitope prediction using *Discotope* with the Rosetta *ab initio* structural model performed comparably to *Bepipred*, at 59% accuracy with an A~ROC~ 0.67 and a significance of *p*\<0.001. Like *Bepipred*, it identified the N-terminal and C-terminal epitope regions (epitopes 1a and III, respectively), as well as a significant portion of epitope II, and portions of epitope 1c. By contrast, *Discotope* using the QUARK *ab initio* structural model showed only modest predictive value, with an A~ROC~ of 0.54


               64.8                                        0.68±0.04                                     \<0.001

Accuracy measures the percentage of correct epitope classification across all residues.

A~roc~ is the area under the curve constructed by the Receiver Operational Characteristics (ROC), which is the function of the sensitivity and specificity of the epitopedegradation of *Pf*CelTOS, with 87% sequence coverage predominantly at the N-terminus and the central region of the molecule, while 35 peptides were generated from the Cathepsin D degradation of *Pf*CelTOS with 78% sequence coverage, 13 peptides were generated from the Cathepsin L degradation of *Pf*CelTOS with 39% sequence coverage, and 10 peptides were generated from the Cathepsin S degradation of *Pf*CelTOS with 31% sequence coverage. Unlike proteasomal cleavage, Cathepsin cleavage appeared more focused and localized to specific segments of the molecule.

![Proteasomal and Cathepsin cleavage maps of CelTOS.\
The proteasomal and Cathepsin D, L and S peptide fragments were separated by UFLC, analyzed on an LCMS-IT-TOF mass spectrometer and then identified using the MASCOT data base. The peptides derived from the proteasomal degradation of CelTOS (blue lines) are denoted above


another parent as expense item (child entity) cannot be added outside of its parent directly. See code below.
 public virtual ExpenseItem AddNewExpenseItem(ExpenseAnalysis analysis,
            string recipientName,
            string purchaseAccountReference,
            string expenseDescription,
            string expenseNotes,
            Money value,
            VATAnalysis vat)
        {
            Validate.IsNotNull<ExpenseAnalysis>(analysis);
       List of railway stations in Cornwall

There are 36 railway stations in Cornwall, United Kingdom, on 6 distinct passenger lines of the National Rail network. Also listed are the 4 railway stations in Devon that make up part of these lines. Heritage and freight-only lines are not listed.

Stations listed alphabetically in table form
All stations are within Cornwall and are listed with their total number of entry/exit users.

Stations listed by line
Stations on the Cornish mainline are listed from east to west. Branch lines are listed from east to west and branch stations are listed from their junction with the mainline out to the terminus.

Saltash to Penzance Cornish Main Line (listed east to west)
Saltash
St Germans
Menheniot
Liskeard
Bodmin Parkway
Lostwithiel
Par
St Austell
Truro
Redruth
Camborne
Hayle
St Erth
Penzance

Gunnislake branch Tamar Valley Line
Keyham (in Devon)
St Budeaux (in Devon)
Bere Ferrers (in Devon)
Bere Alston


at police station as he took suspect's temperature in covid checks HAPPY MEAL McDonald’s worker pays customer’s bill after he calls mum to ask for her order COP OFF Policewoman & married PC fired over on-duty fling after squad cars tracked with GPS EUGE NEWS Princess Eugenie 'so excited' to be expecting baby as Andrew & Fergie share joy Exclusive HAPPY MEAL McDonald’s worker who paid for lad’s meal has secretly bought food for MONTHS HERE WE SNOW! Leeds hit by SNOW as temps plummet to -5 as Brits brace for 65mph gusts today

Detective Sgt Rob Trickett, of Blackburn CID, said: "While we do believe that this was a targeted attack it was nonetheless terrifying for this man and especially for his young son who was with him\[[@CR12], [@CR13]\]. The sodium-glucose transport 2 (SGLT-2) inhibitors lower blood glucose through an increase in renal excretion of glucose with a secondary benefit of decreasing glucose toxicity \[[@CR15]\]. They increase hepatic glucose production, glucagon secretion, ketogenesis, and lipid oxidation \[[@CR15], [@CR16]\]. A significant side effect of their treatment is a modest weight loss, a decrease in blood pressure, and a modest reduction in insulin resistance \[[@CR15], [@CR16]\]. Weight loss itself decreases hepatic triglycerides, peripheral and visceral adipose tissue mass, and plasma triglycerides \[[@CR17]•\]. GLP-1 receptor agonists and SGLT-2 inhibitors secondarily decrease insulin resistance in patients in proportion to their effect in promoting weight loss. Thiazolidinediones (TZDs) decrease insulin resistance directly through activation of PPARγ receptors which facilitate differentiation of mesenchymal stem cells into adipocytes, promote lipogenesis in peripheral


and even macular edema \[[@CR62]\]. It now appears that sodium transporters in the proximal tubule including NHE3 also contribute to sodium reabsorption \[[@CR63]\]. Increased vascular permeability through increased vascular endothelial growth factor secretion and decreased systemic vascular resistance are non-kidney factors that contribute to the edema \[[@CR63]\].

Table [2](#Tab2){ref-type="table"} presents data on TZD-mediated edema from randomized, controlled clinical trials and a large French Pharmacovigilance data base. The incidence of TZD-induced edema depends on drug dose, the stage of glucose intolerance, and the magnitude of the underlying cardiovascular disease. The lowest incidence is in prediabetes (DREAM study), with intermediate incidence in T2D (ADOPT and French PharmacoVigilance studies), and the highest in those with advanced cardiovascular disease (PROactive and IRIS studies) \[[@CR31]•, [@CR34], [@CR64]••, [@CR65]••, [@CR66]•\]. The extent to which TZDfailure (\< 1%) \[[@CR34]\]. Patients without diabetes but with insulin resistance and a previous ischemic cerebrovascular event had an increase in the incidence of heart failure and hospitalization for heart failure, but these were not related to pioglitazone treatment \[[@CR65]\]. VA ambulatory patients with heart failure and diabetes had an increase in heart failure hospitalizations and death over a 2-year follow-up period and they were unrelated to TZD treatment \[[@CR72]••\]. Three studies (PROactive, RECORD, and A GSK-sponsored ECHOCARDIOGRAPHIC study) showed significant increases in heart failure hospitalizations in patients treated with a TZD \[[@CR43]••, [@CR61], [@CR64]••\]. The populations in these three studies had in common a long duration of diabetes and a high prevalence of preceding cardiovascular events. While death from heart failure was increased by rosiglitazone in the RECORD


stroke and with insulin resistance. No diabetesPioglitazone19235 years67 (3.5%)44 (2.3%)1 (0.0005%)Placebo192866 (3.4%)36 (1.87%)2 (0.001%)*p* value0.890.350.51APPROACH \[[@CR59]\]Type 2 DM with known coronary atherosclerosisRosiglitazone333Median 18 months8 (2.4%)Glipizide3393 (0.9%)*p* value0.14Echocardiographic study (Wilding) \[[@CR61]\]Type 2 DM NYHA class I or II heart failureRosiglitazone11052 weeks36 (32.7%)^a^Control11420 (17.5%)^a^*p* value0.037ADOPT \[[@CR34]\]Type 2 DMRosiglitazone1456Median 4 years9 (0.6%)Glyburide14414 (0.3%)1Metformin14548 (0.55%)1*p* valueVs. met 0.26VA ambulatory \[[@CR72]••\]Ambulatory patients with diabetes mellitus and heart failurePioglitazone or rosiglitazone8182 years134 (16.4%)168 (20.5%)No insulin sensitizers4700741 (15.8%)1192 (25.4%)*p* value0.970.80^a^Worsening heart failure requiring increased medications

Rosiglitazone treatment of patients with T2D and NYHA functional class I or II heart failure for 52 weeks did not affect LVEF even though the patients experienced new or worsening edema and increased congestive heart failure medications \[[@CR61]\].

Thiazolidinediones and Bone Fractures {#Sec9}
=====================================

The second major complication of TZD therapy is an increase in the risk of bone fractures.A California Model For Campaign Finance

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In American politics, there's no money game bigger than the one played in California.

Our gubernatorial candidates can receive donations 10 times larger than the maximum legal donation to a candidate for president.

If only our governors were 10 times as good as our presidents.

The Center for Governmental Studies, whose president Bob Stern has been working on political reform and campaign finance in California for four decades, is determined to bring the state political money game under control.

The center recently released not a series of incremental proposals but something much better: a comprehensive plan for redesigning campaign finance in California.

This plan, in the form of a model law that the center says could be exported to other states,


an EM treated with curcumin and piperine, the tamoxifen and endoxifen AUC~0--24h~ decreased 22.0% (95%CI: −29.0% to −14.2%, *p* \< 0.01) and 18.4% (95%CI: −36.1% to 4.3%, *p* = 0.09), respectively. C~trough~ showed similar results ([Table 3](#cancers-11-00403-t003){ref-type="table"}). Although, the interaction term was only significant for tamoxifen AUC~0--24h~ and C~trough~ with curcumin and piperine. There was no period effect, which implicated no decline in tamoxifen nor endoxifen plasma concentrations based on altered tamoxifen metabolism over time. Individual tamoxifen and endoxifen AUC~0--24h~ can be found in [Figure 2](#cancers-11-00403-f002){ref-type="fig"} and in [Supplementary Figure S1](#app1-cancers-11-00403){ref-type="app"}.

2.3. Toxicities {#sec2dot3-cancers-11-00403}
---------------

There were no unexpected serious adverse events (SAE) during combined treatment with curcumin or curcumin plus piperine related to the study procedures. There was one serious adverse event, which was assumed to be not related toany of the study drugs (collapse with unknown origin). Toxicity profiles were similar between the different treatment phases, although more hot flashes and fatigue were observed in patients treated with curcumin +/− piperine compared to tamoxifen monotherapy ([Table 4](#cancers-11-00403-t004){ref-type="table"}). Interestingly, three patients suffered from grade 2--3 diarrhea during treatment with curcumin and piperine, whereas none of the patients experienced diarrhea when treated with tamoxifen monotherapy.

3. Discussion {#sec3-cancers-11-00403}
=============

In this study, a modest but significant decrease was found in both tamoxifen and endoxifen plasma concentrations during concomitant administration of tamoxifen and curcumin, compared to tamoxifen monotherapy. This effect was even more pronounced when tamoxifen was administered with curcumin and piperine. Furthermore, patients with an extensive CYP2D6 phenotype seem to be at greater risk of experiencing this herb--drug interaction, compared to


into plasma within 30 minutes by vortex mixing and centrifugation for 10 min at 2500--3000× *g* at 4 °C. Plasma concentrations were measured using a validated liquid chromatography with a tandem mass spectrometry method (UP-LCMS/MS) \[[@B24-cancers-11-00403]\]. Predefined pharmacokinetic parameters were tamoxifen and endoxifen exposure (expressed as dose-corrected area under the curve from the pre-infusion time point until 24h (AUC~0--24h~)), maximum concentration (C~max~), time until maximum concentration (T~max~), and lowest plasma concentration (C~trough~). Pharmacokinetic outcomes were calculated using Phoenix WinNonlin version 8.1 (Pharsight, a Certara Company, Princeton, NJ, USA).

4.4. Toxicity {#sec4dot4-cancers-11-00403}
-------------

Toxicity rates during tamoxifen monotherapy and tamoxifen concomitantly with curcumin +/− piperine were determined during patient follow-up until the end of the study using Common Terminology Criteria for Adverse Events (CTCAE version 4.0, National Cancer Institute, Bethesda, MD, USA)expensive policies because of the lack of options covering higher risk.

PROTECTION FROM WILDFIRE:

Some steps that could be taken to protect one’s house include having closed eaves, rather than open ones, and having dual-pane windows with tempered screens instead of single-pane windows with no screens. Techniques such as controlled burning also seem to be one way of protecting oneself from damage caused by wildfires.

As the fires rage on, let us hope that the burden of higher insurance premiums on householders in high-risk areas lightens.

ABOUT THE AUTHOR


read the following article.
Once you have read it, look at the generated HTML (and more specifically the names of the input fields) with my example and yours. Then compare and you will understand why yours doesn't work.

The only issue in a forcible detainer action is the right to actual

and immediate possession. Id. at 435. To prevail in a forcible detainer action, a plaintiff is not

required to prove it has title to the property; rather, a plaintiff is only required to show sufficient

evidence of ownership to demonstrate a superior right to immediate possession of the property. Id.

        To prevail and obtain possession in a forcible detainer action following a foreclosure sale,

a plaintiff must show: (1) the substitute trustee conveyed the property by deed to the plaintiff after


Q:

How do I change the colors displayed in cygwin rxvt?

When I use "[\e[34m]sometext" i get sometext in blue, but can I specify the shade of blue somewhere?

A:

If your rxvt has 256 colors enabled, you can use extended color codes (e.g. "^[[38;5;36m"). Try this script to test if your terminal has 256 colors enabled. Probably you need to patch/recompile it or download another version. I recommend this tutorial.

A:

You're using an ANSI escape sequence, which has very limited color options.  I use an .Xdefaults file (explained in this tutorial).  These options won't make your shell prompt all colorful, but is used by editors such as vim.
Be aware that .Xdefaults can be picky about UNIX (CR) vs Windows (CRLF) line endings.  Use d2u or u2d to switch lineQ:

Getting the default(?) element of a jQuery() selection

I am sure there is a simple solution.
The starting scenario was the following.
I create a <select> element and populate it dynamycally:
function CreateDropDown(name, id, optionList)
{
    var combo = $("<select></select>").attr("id", id).attr("name", name);

    $.each(optionList, function (i, item) {
        combo.append("<option value='"+item.val+"'>" + item.el + "</option>");
    });

    return combo;
}

The aim was to extract the outerHTML. The following works right:
combo[0].outerHTML();

But I feel that indexing the array is very rough. At least in all that cases where the jQuery() function return a single element array.
Question
Whenever the jQuery() function return a single element array, is it possible to get the unique element without array indexing?
Demo

A:

jQuery objects are inherently collections of


DOM objects, and there is no syntactic way to treat a jQuery object as wrapper around a single item.
jQuery documentation suggests using get method to access individual DOM elements. It does not comment on performance difference between indexing operator and .get(), but it does say that "each jQuery object also masquerades as an array", so it would be ok to assume that indexing operator just adds another method call.

A:

If you "feel that indexing the array is very rough", you could write your own nice helper method. Something like a:
window.$$ = function(){
   return jQuery.apply(jQuery,arguments)[0];
}

Usage:
var combo = $$("<select></select>");
console.log( combo.outerHTML );

*binaryRows) NextResultSet() error {
	resLen, err := rows.nextNotEmptyResultSet()
	if err != nil {
		return err
	}

	rows.rs.columns, err = rows.mc.readColumns(resLen)
	return err
}

func (rows *binaryRows) Next(dest []driver.Value) error {
	if mc := rows.mc; mc != nil {
		if err := mc.error(); err != nil {
			return err
		}

		// Fetch next row from stream
		return rows.readRow(dest)
	}
	return io.EOF
}

func (rows *textRows) NextResultSet() (err error) {
	resLen, err := rows.nextNotEmptyResultSet()
	if err != nil {
		return err
	}

	rows.rs.columns, err = rows.mc.readColumns(resLen)
	return err
}

func (rows *textRows) Next(dest []driver.Value) error {
	if mc := rows.mc; mc != nil {
		if err := mc.error(); err != nil {
			return err
		}

		// Fetch next row from stream
		return rows.readRow(dest)
	}
	return io.EOF
}


new rituals for customers is a great way to heighten their enjoyment and to build strong brands.

Relationship with a community. Through the ages, religious life and social life went hand in hand. People belonged to the same religious congregation their entire lives, and relied on fellow members for companionship, financial assistance, and social support. The found their friends, well-wishers, and spouse, and socialized their children there. Today, brand communities, fan clubs, and social networks provide many of these same benefits. Many motorcycle enthusiasts spend their weekends and vacations with their Harley Owners Group at rides and rallies. In user forums and chatrooms of companies like Hewlett Packard, Microsoft and Texas Instruments, tech enthusiasts devote hours upon hours helping others solve their problems without pay. Brands like Jeep, thehurt and everything... just chill out for a second.

Iha: Well, let's all be calm.

Corgan: Hey, just wait, just give it a minute, okay? We're gonna play forever, really. Just, let's take it easy.

Wretzy: This will be the longest concert you will ever be at.

Corgam: Okay, so let's just...

Wretzky: Take a deep breath.

Corgan: Let's just take it easy for a minute, let's make sure everybody who got injured gets up and out, okay? Please, okay?

Wretzky: Why are [unintelligible]

Corgan: I know you don't want anybody to get hurt, I know that's not why you're here. Just relax, just for a minute, okay? I promise we'll play a normal show, everything will be groovy, we just don't want anybody to get hurt.

Iha: And just don't beat us up. Think of a


good book you've read while you're waiting, maybe that'll calm your... your mind. Think of a nice pool of water. You're drifting down the pool of water, and you're feeling groovy. Alright maybe not. Just chill out, and try to have a good time.

Corgan: Hey, take it easy, we still... we gotta still gotta lot of people got hurt, so... Just please wait a minute, okay? Just wait. Please, don't push, okay? Okay? There's a lot of people who fell down and were getting trampled and everything, we just gotta be cool. And please not try not to throw shit at us while we're talking to you. We'd appreciate that, too. So, how is everybody? Please, okay? Don't make the situation any worse by hitting us with stuff,understand. And if you love the people around you, and you respect us, you’ll understand and just peaceably go home, and that’s it. You can hate us, you can fucking whatever, I don’t care. But I’m not gonna watch you get hurt, that’s it.

Iha: We’re really sorry. We hope you rock for a while. But there… people seriously hurt, you gotta go. We can’t play music for people getting beat over the head. Sorry.

Corgan: Thanks, we love you, please understand.


between this phone and the leaked Moto X5. Most obviously in the rear camera department, with the Motorola adoption of the iPhone-esque camera module placement compared to the Moto X4’s horizontal (Z3 Play) layout. Likewise, the Moto X5 image only suggested a notch might be in use due to the configuration of the top portion of the display. Unlike this image which clearly is pushing the notch as one of the main design points. There are other differences too which further suggests the two phones are as unrelated as any other two lines from Motorola.

Summary

While this is the first time the Motorola One Power has been reported on, the image provided does paint a very clear picture of what the phone will look like and offer, including thesaid the Patriots also use the wall tactic.

"Our job is not to insult another team, particularly from a coach or owner's standpoint," Johnson said. "That's not what we're here to do."

After a series of high-profile moves in the offseason, when the team brought in LaDainian Tomlinson, Jason Taylor and Antonio Cromartie, things really heated up in the summer when the Jets became reality-TV stars on HBO's "Hard Knocks."

Ryan's foul language drew the ire of many, including former Indianapolis coach Tony Dungy, and all the boasts about being "soon-to-be champs" rubbed other teams the wrong way.

September brought an investigation by the league after reporter Ines Sainz, of TV Azteca, said she felt uncomfortable in the team's locker room. As a result, the NFL developed a workplace conduct program, underwritten


TCP standard (99% purity) was purchased from Sigma-Aldrich, USA. Chromatographic-grade methanol was purchased from Burdic & Jackson, USA. All other chemicals and reagents used were of pure analytical-grade and available commercially. Stock solutions (10 g·L^−1^) were prepared with methanol, sterilized by membrane filtration (0.45 µm), and stored in dark bottles at 20°C before use.

Czapek-Dox medium (CDM) containing (in gram per litre) sucrose, 30; NaNO~3~, 2; KCl, 0.5; MgSO~4~, 0.5; K~2~HPO~4~, 1; Fe~2~(SO~4~)~3~, 0.01; and peptone, 0.5; and mineral salt medium (MSM) containing (in gram per litre) (NH~4~)~2~SO~4~, 2; MgSO~4~·7H~2~O, 0.2; CaCl~2~·2H~2~O, 0.01; FeSO~4~·7H~2~O, 0.001, Na~2~HPO~4~·12H~2~O, 1.5; and KH~2~PO~4~, 1.5 were used for the isolation of fungal strains.

Enrichment and Isolation of the Chlorpyrifos-degrading Fungi {#s2b}
------------------------------------------------------------

Activated sludge samples were collected as the inoculum from an aerobic chlorpyrifos-manufacturing wastewater treatment systemthe real value of an independent variable, *X* ~0~ is the real value of an independent variable at the center point, and ~Δ~ *X* ~i~ is the step change of real value of the variable *i* corresponding to a variation of a unit for the dimensionless value of the variable *i*. The symbols and levels of the three independent variables are presented in [Table 1](#pone-0047205-t001){ref-type="table"}. The dependent variable was the degradation of 50 mg·L^−1^ chlorpyrifos by strain Hu-01 by hour 12. Randomised block design was conducted in order to minimise the effects of unexplained variability in the observed response because of extraneous factors [@pone.0047205-Chen5]. The data were analyzed by using the response surface regression procedure of the SAS software to fit the following quadratic polynomial equation (Eq.(2))where Yi


medium components for a variety of microorganisms [@pone.0047205-Moon1], [@pone.0047205-Yong1]. Previous studies have shown that the application of statistical experimental design techniques in biodegradation processes can result in improved yields of degradation and allow the rapid and economical determination of the optimum culture conditions with fewer experiments and minimal resources [@pone.0047205-Chen3], [@pone.0047205-Chen5], [@pone.0047205-Dritsa1]--[@pone.0047205-Chen7]. In the present study, RSM is first employed to optimize culture conditions favouring chlorpyrifos degradation. The optimization parameters investigated include pH, temperature and culture time. The results of the experiments were statistically analyzed and the significance and effect of each factor on responses was evaluated. The optimum degradation conditions were determined to be pH 6.5, 26.8°C, and culture time 4.7 d. Under these conditions, strain Hu-01 reached a maximum chlorpyrifos degradation of approximately 85% within 12Q:

format a string using a string and (padded) number

I'm assembling a url for an http request
baseurl = 'http://..'
action = 'mef'
funcId = 100
year = 2018
month = 1

url = '{}?action={}&functionId={}&yearMonth={}{}'.format(baseurl, action, funcId, year, month)

What's bugging me is I need the month number to be padded with a 0 if its less than 10.
I know how to pad a number if its the only variable to format:
'{0:02d}'.format(month)  # returns: 01

Though when I try this in:
'{}?action={}&functionId={}&yearMonth={}{0:02d}'.format(baseurl, action, funcId, year, month)

It results in the error:
ValueError: cannot switch from automatic field numbering to manual field specification

I assumed it's because the other brackets aren't shown what type of variable to expect, but I cant figure out with what character to specify a string.

A:

Change {0:02d} to {:02d}.
The zero preceding the colon is telling to use


drying of wafers and substrates, referred to as an IPA dryer, involves immersing the wafers in a liquid/gaseous bath of IPA (isopropyl alcohol). The IPA dryer is based on the principle that, since water is miscible with alcohol, the alcohol will mix with and carry away the water present on the surface of the wafer, eventually leaving only a film of alcohol on the wafer. Since the alcohol has a high vapor pressure, it quickly evaporates leaving the surface of the wafer dry. A negative aspect of the IPA drying process is that the alcohol may leave organic residue remaining on the surface of the wafer as it evaporates. Considering the high level of cleanliness required for the surface of the wafers, this is an unacceptable drawback toMarkkanen rise, Grant has fallen and he has become kind of the forgotten man on this team. So far in January, Grant has posted 4.3 points per game on 26.2 percent from the field and has shot the ball at a 6.7 percent clip from behind the 3-point line.

That’s obviously bad timing for a slump, and on his own, Grant doesn’t have a ton of trade value. He doesn’t move the needle enough for a contending team looking for that last piece to solidify its roster for the stretch run. At the same time, rebuilding teams aren’t going to give up an asset to obtain him as a development project.

Maybe Grant’s inclusion into the trade talks is more of a sweetener in a trade package that includes Mirotic,


or other veterans like Justin Holiday, or Robin Lopez.

Grant still has upside, and teams could view him as a valuable add-on in a trade as long as he’s not the focal point of the trade. He shot the ball 36.6 percent from 3-point land last season, and he shot the ball 44.3 percent and 47.4 percent from this range in November and December of this season respectively. He can run an offense, and although he isn’t a flashy playmaker he averages 7.8 assists per 36 minutes this season. There looks to be a place for him in the NBA as a solid, second-unit guard.

As KC Johnson indicates, if Grant leaves that would open up playing time for Cameron Payne. However in three years in the NBA, Payne hasn’tabuse

Rights group Defense for Children International – Palestine (DCIP) cited in a report a number of recent cases of Palestinian minors being handed prison sentences for periods ranging between 12 to 39 months, with up to three years’ probation.

Out of 65 cases documented by DCIP in 2015, “more than a third of Jerusalem youth were arrested at night (38.5 percent), the vast majority (87.7 percent) were restrained during arrest, and only a slim minority of children (10.8 percent) had a parent or lawyer present during interrogation.”

Youth described being kicked and punched while handcuffed, choked, and having a door slammed in their face.

Interrogations of Palestinian children can last up to 90 days according to prisoners’ rights group, Addameer, during which in addition to being beaten and threatened, cases of


Substance abuse is a widespread problem that is associated with a predisposition to increased risk-taking in general. Longitudinal and cross-sectional studies indicate that those who are more risk averse, or high harm avoidant, are less likely to use and abuse drugs (Masse &Tremblay 1997;Finn 2002). Such individuals appear to be strongly drug avoidant. What brain mechanisms drive aversion to risky behavior such as illicit drug taking? The long-term goal of this research is to clarify the brain and cognitive mechanisms that detect the risk associated with certain behaviors, including illicit drug use, and how these brain mechanisms are activated to avoid risky behavior. The proposed research goes beyond descriptive theories to leverage our separately developed new and integrative computational neural models. The medial prefrontal cortex (mPFC) and connectedConcept of Operations Evaluation for Using Remote-Guidance Ultrasound for Exploration Spaceflight.
Remote-guidance (RG) techniques aboard the International Space Station (ISS) have enabled astronauts to collect diagnostic-level ultrasound (US) images. Exploration-class missions will likely require nonformally trained sonographers to operate with greater autonomy given longer communication delays (> 6 s for missions beyond the Moon) and blackouts. Training requirements for autonomous collection of US images by non-US experts are being determined. Novice US operators were randomly assigned to one of three groups to collect standardized US images while drawing expertise from A) RG only, B) a computer training tool only, or C) both RG and a computer training tool. Images were assessed for quality and examination duration. All operators were given a 10-min standardized generic training session in US scanning.


Q:

"Red Hot" Objects & the Ultraviolet Catastrophe

It is common for introductory courses in quantum physics to justify the need for a new model with the ultraviolet catastrophe, but I cannot seem to grasp it.
The flaw in the Rayleigh-Jeans law appears to be that it suggests an always increasing intensity relative to an increasing frequency, and thus implies an infinite energy source. However, I struggle to see how the model explains even observations they would have made at the time, such as why things glow red when heated.

Graphs such as these suggest that the intensity of blue light would be so much higher than red light, that nothing could ever glow red. What am I missing?

A:

As you say, Rayleigh-Jeans law did not adequately explain observations made at the time.really great so it has mirror of these Dungeons & Dragons that have captivated generations of kids in recent decades. If you have not heard or never played with one of them, by the way in which the guys from Unepic have carried out this amazing game RPG and platforms.

Difficult but with much logic

The difficulty of the game can be selected and we have it from the easiest to the most high, but even in the lowest, there are a number of rules that must be respected for not dying every few screens. Keep in mind that each one of the obstacles that exist in the game are designed so that our hero combat them as you would in the Board game so you have to be very


concludes this case is suitable for decision
without oral argument. See Fed. R. App. P. 34(a)(2).
(“CAT”). Our jurisdiction is governed by 8 U.S.C. § 1252. We review for

substantial evidence the agency’s factual findings. Zetino v. Holder, 622 F.3d

1007, 1012 (9th Cir. 2010). We deny in part and dismiss in part the petition for

review.

      Santillano does not claim she suffered harm in Guatemala, but fears harm if

she returns. Substantial evidence supports the BIA’s determination that Santillano

failed to establish a causal nexus between the harm she fears and a protected

ground. See id. at 1016 (“An [applicant’s] desire to be free from harassment by

criminals motivated by theft or random violence by gang members bears no nexus

to a protected ground.”). Thus, Santillano’s asylum claim fails.

   Immigration and Customs Enforcement arrests in the last year jumped to their highest levels since 2014, with increases in those picked up who had either no criminal history or whose criminal backgrounds are unresolved, according to data released by the agency Friday.

The agency has come under fire by advocates who believe its approach toward immigration enforcement has produced fear in the lives of people who are merely trying to get by. President Donald Trump’s executive orders have wiped away previous administrations’ practice of prioritizing those with serious criminal histories for deportation, in favor of an approach that makes nearly all undocumented immigrants a priority.

Still, ICE maintains that it focuses on those with criminal histories in its work. To that end, of the 158,581 arrested by the agency this


Jobs Are Being Automated. The Solution? Give Everyone Free Money.

The idea of a “basic income” is not as far out as it seems.

Photo courtesy of Michael Doss/Flickr

The “next wave of economic dislocations” will not come from outsourcing or immigrant labour, declared Barack Obama during his farewell speech, but from automation.

This is news to Donald Trump, who places the blame for American job losses on China and Mexico, but the data show his statements reflect racism, not reality. Between 2000 and 2010, 5.6 million manufacturing jobs were lost, jobs that Trump has promised to “bring back” to America.

But here’s the thing: these jobs never actually left. Up to 85 percent of them were automated, not outsourced, and even Carrier has acknowledged it will automate the jobs it didn’t sendrapidly so it needs workers; these jobs don’t pay very well; and Amazon will automate as many of these jobs as possible, as soon as possible.

In 2016, Amazon had 45,000 robots working in its warehouses, and it had been adding about 15,000 each year. The company claimed that those robots didn’t displace workers, but that’s only because its growth has been so strong. There’s no question that fewer people have been hired as a result, but limitations in the abilities of the robots kept more jobs from being replaced. That may soon change.

The problem with the existing robots is that they can move things around the warehouse, but they can’t pick individual items to pack an order. However, progress is swiftly being made on such a robot, further


Kolento: "It's all about the RNG. I just try to maximize my chances"

Aleksander “Kolento” Malsh is probably one of the most well known players in the Hearthstone scene. He has been around since the early stages of the game, and was one of the favorites for the Hearthstone World Championship in 2014. He has managed to take first place in 12 tournaments, of which seven were held in 2015. Very few people dare argue with Kolento’s analyses when it comes to Hearthstone plays, and those skills made some people dub him as “Godlento”. Proof can be found in the first two Top 5 Plays video, made by Trolden, in which he is awarded the #1 spot. We interviewed him right after he eliminated ThijsNL in the Under Bracketradio manufacture and sold the factory and remaining components to the Symphony Gramophone and Radio Company.

AJS Racing under AMC

Under AMC the AJS badge may have been put on the "bread and butter" Matchless motorcycles, but the Colliers were mindful of the AJS racing heritage, and used the name on some innovative racing machinery. These racing bikes kept the AJS name alive.

In 1935, at the Olympia Show, an air-cooled SOHC AJS 50° V4 was shown, a fully equipped road going version, which did not make it into production. In 1936 Harold Daniell rode a supercharged race version in the Isle of Man Senior TT, but despite its high top speed, it lacked acceleration.

In 1939, a water-cooled and supercharged version of the 495 cc AJS V4 was built to compete


       while (number != numberToGuess ) {
                a++;
                System.out.print("Rate eine Zahl zwischen 0 und 100: ");
                number = s.nextInt();
                if (number == numberToGuess) {
                    System.out.println("richtig");
                  [The choice of the extent of the surgical intervention in patients with soft-tissue tumors of the trunk].
Data on 145 cases of soft-tissue tumor of the trunk were analysed. Tumor was located on the chest or back in 81 patients and deep in the anterior abdominal wall--in 64. When intramuscular sarcoma is removed, a 2-3-cm margin should be left around the palpable mass. Five-year survival in the entire group of patients with tumors of the chest and back was 59.4% +/- 2.4. Five out of ten cases with tumor of the abdominal wall survived over 5 years.


all rich, so it’s like, we don’t need the money, but at the same time, to go out and do 60 or 70 shows and come back and make as much as I make in one night after a year of that, is pretty hard.”

“I don’t do things for money, but it’s pretty difficult to put everything else aside. Because I’m saying, “Okay, if I’m putting a year of my life aside, I’m not going to make any money, number one. Which I don’t need money, it’s okay, I can get away with that. But the energy that it takes to do all of that and my fans sit there and hound me, as much as they love Chickenfoot, they hound me to go out and do [theMCVE at all.

"incomplete" - The C in MCVE means complete.
"logically incoherent" - The V in MCVE means verifiable.  An incoherent example is not verifiable.
"unrelated to the question" - The E in MCVE means example.  If the code is unrelated to the question, it is not an example of what the question is asking.
"does something different than intended" - This is a little unclear.  But if you mean that it does something different to what the Question is asking, then either it is not an example, or it is not verifiable.

If the problems in the MCVE are minor, they can be ignored.
However, the purpose of the MCVE is to allow people to understand the question enough to be able to answer.   So


part, but also states the username and
password you should use.

The main Unicode mailing list (called unicode)
once in a while has a thread that is really very interesting and you
really must read, but it's buried in a thousand
other messages that are not even worth downloading, even in digest
form. Luckily, this problem meets a tidy solution with LWP:
I've written a short program that, on the first of
every month, downloads the index of all the previous
month's messages and reports the number of messages
that has each topic as its subject.

The trick is that the web pages that list this information are
password protected. Moreover, the URL for the index of last
month's posts is different every month, but in a
fairly obvious way. The URL for March 2002, for example, is:

http://www.unicode.org/mail-arch/unicode-ml/y2002-m03/

Deducing the URL for thethat we were a big help in that situation."

Just after Joyce had passed her badge for signal corps, she met William at St. Anne's Church. William was with the chaplain when Joyce's grandmother invited the two of them to tea.

"The rest is history," Joyce said.

By December 1943, William and Joyce were married, and soon after Joyce was pregnant. Joyce retired as a first private.

Meanwhile, both their military careers would bring them to brush shoulders with famous figures and places. Joyce was in the Army with Princess (now Queen) Elizabeth, who was in the motor vehicle squad. They were even in the same barracks.

William was on the general's staff at Normandy and then traveled through France. Much of the time, he and the others weren't even sure of their


NAP) that mediate reduction of nitrate to nitrite. Nitrite can enter the denitrification pathway in processes mediated by nitrite reductase enzymes encoded by *nirS* or *nirK* genes (see [@B52]). Alternatively, in DNRA nitrite is reduced to NH~4~^+^ by the NrfA enzyme encoded by *nrfA* (see [@B38]). Consequently, molecular analyses of *nirS/nirK* and *nrfA* genes can be used to investigate the genetic potential in an environment for either denitrification or DNRA.

Previously, we demonstrated a decline in rates of denitrification and DNRA, and a corresponding decline in abundance of genetic markers for these processes, down the nitrate gradient of the Colne estuary ([@B10]) at a single time point (February 2005). Furthermore, previous research revealed seasonal variability in rates of denitrification ([@B12]); and spatial variability in rates of nitrate exchange acrossnitrate and nitrite were 0.002 μM, ammonium 0.003 μM. Analytical accuracy for nutrient analysis was maintained by membership of a quality assurance scheme ([www.quasimeme.org](http://www.quasimeme.org)).

Measurement of Rates of Denitrification and DNRA
------------------------------------------------

Denitrification rates to both N~2~ and N~2~O ([@B9]) and DNRA rates ([@B10]) were determined simultaneously on intact sediment cores. Briefly, denitrification and DNRA rates were measured by ^15^N-labeled nitrate addition to sediment cores. Five cores of sediment (∼10 cm deep) were collected in Perspex tubes (3.4 cm internal diameter, 22 cm length) from each site. On return to the laboratory, the cores were put in an incubation tank at *in situ* water temperature and submerged in site water that was vigorously bubbled with air overnight to re-equilibrate. Next day, the rates of denitrification and DNRA were measured by ^15^N


estuary. Black circles represent the estuary head (EH), red squares mid-estuary (ME) and blue triangles the estuary mouth (EM). A, April; J, June; Au, August; O, October; D, December; F, February 2006.](fmicb-06-00542-g0002){#F2}

16S rRNA gene abundances at each site from April 2005 to February 2006 (Figure [3](#F3){ref-type="fig"}) indicated a significant site and time effect (two way ANOVA, *P* \< 0.001). Gene abundances were highest at the EH and significantly higher than in sediments from ME and the EM (*P* \< 0.001); while there were no significant differences between ME and EM sediments (*P* = 0.071). Within individual sites, there was only significant variation in 16S rRNA gene copy abundances between months at ME in October (ANOVA *P* \< 0.008, Bonferroni correction).

![**Spatial and temporal variation in 16S rRNA gene copysystems.

Denitrification and DNRA compete for nitrate and carbon within sediments. The availability of nitrate and organic carbon are key factors controlling rates of benthic denitrification ([@B7]; [@B12]; [@B14]). Previous studies of the Colne estuary have indicated that denitrification at the EH is carbon limited, while denitrification ME and at the EM is nitrate limited ([@B33]). However, the ratio of electron donor to acceptor can influence the pathway and fate of nitrate. DNRA has a higher affinity for nitrate than denitrification and may be favored in nitrate-limited, carbon-rich environments ([@B20]; [@B3]; [@B21]). This is due to the requirement of only 5 electrons to reduce nitrate in denitrification verses the eight required for DNRA ([@B47]). DNRA may therefore outcompete denitrification in nitrate-limited environments where these organisms gain more energy from


to activity measurements, indicating that substantial post-transcriptional, protein assembly and/or environmental factors ultimately control activity. For example, [@B17] examined the roles of NAR and NAP in nitrate reduction in *Pseudomonas sp*. and found that nitrate reductase activity and *napA* or *narG* gene transcription were not necessarily positively correlated, leading them to conclude that there were subsequent post-translational modifications even in pure culture. In soils, [@B25] demonstrated the dramatic effect increasing pH had on reducing denitrification activity, yet this trend was not reciprocated in *nirS* and *nosZ* gene and transcript abundance, leading them to conclude that reduction in pH affected denitrification after transcription. In the highly nutrified Colne estuary, the high nitrate concentrations in the water are drastically reduced within the surface sediment by rapid nitrate reduction in thesub-oxic zone (the surface oxic layer of sediment is usually \<2--3 mm depth ([@B36]). Consequently, benthic nitrate reducers are operating at very low pore water nitrate concentrations where rates of nitrate reduction approximate to first order kinetics; well below any nitrate-saturating concentrations when nitrate reduction might correlate with genetic potentials. The correspondence between rate processes and gene abundances/transcripts is likely to be closer the nearer *in situ* substrate concentrations are to saturating concentrations of substrates. Furthermore other physical-chemical factors such as temperature or pH may control key enzyme activity, and *in situ* rates, without necessarily directly affecting transcription. Further and future studies will focus on determining the links between environmental conditions, nitrate and nitrite reducing communities and rates of nitrate reduction and controlling factors influencing the fate of


Q:

How to list the files in a zip in powershell?

I am new to powershell and looking to list all the files, contained in  zip files in a directory. I don't want to use any third-party tool.
Structure of the directory is
mydir > dir
a.zip
b.zip
c.zip

with each file containing files named 1.txt or 2.txt or 3.txt

I am trying to get an output in the form

a.zip:1.txt
a.zip:2.txt
b.zip:files\3.txt
b.zip:4.txt
c.zip:1.txt
d.zip:10.txt

and so on.
Unfortunately my environment is not 4.5 but 4.0.
I was able to write up this code but it still needs a lot of parsing for clean up as unzip  gives a lot of extra information.
$packagedir="C:\Packages"
$unzipcmd = "c:\bins\unzip.exe -l"
$unmatchstr = "*Archive*"
pushd .
cd $packagedir

$filelist= Get-ChildItem -Recurse | Select-Object -ExpandProperty FullName

 foreach ($item in $filelist)
 {$ziplist = Invoke-Expression "$unzipcmd $item";
 foreach ($item2 in $ziplist)
service treatment records, reports of post-service treatment, and the Veteran's own statements in support of his claims. The Veteran was afforded a VA examination responsive to the claims for service connection of bilateral hearing loss disability and tinnitus.  McClendon v. Nicholson, 20 Vet. App. 79 (2006).  The opinion was conducted by a medical professional, following thorough examination of the Veteran, solicitation of history, and review of the claims file.  The Board has reviewed the examination report, and finds that it is adequate for the purpose of deciding the issues on appeal.

The Board also observes that the AVLJ that presided over the Veteran's June 2011 hearing, clarified the issues on appeal and explained the concept of service connection claims, as well as explained the


after the noise exposure.  See Prejean v. West, 13 Vet. App. 444, 448-49 (2000) (stating that factors for assessing the probative value of a medical opinion are the physician's access to the claims folder and the thoroughness and detail of the opinion).

For the foregoing reasons, the preponderance of the evidence is against the claims for service connection of bilateral hearing loss disability and tinnitus.  The benefit-of-the-doubt doctrine is therefore not for application, and the claims must be denied.  See 38 U.S.C.A. § 5107(b); 38 C.F.R. § 3.102; see also Fagan v. Shinseki, 573 F.3d 1282, 1287 (Fed. Cir. 2009).

ORDER

Service connection for bilateral hearing loss disability is denied.

Service connection for tinnitus is denied.

____________________________________________
MICHAEL D. LYON
Veterans Law Judge, Board of Veterans' Appeals

Department of Veteransshould not only be prevention of relapses, but prevention of new lesion development by immunotherapy under close monitoring. Alterations in Müller cells have been also described in a rodent model of NMOSD.^[@R9]^ This pathology was dependent on both AQP4Ab and T cells, indicating the importance of T-cell control to achieve good control of NMOSD.

It is known that the shape and size of retinal fovea evaluated by OCT differ among different ethnic groups. In this regard, data from both Caucasian and Asian patients are precious and useful. The size of the avascular area in the fovea may influence OCT evaluation.^[@R10]^ Therefore, future studies should evaluate the avascular area as well.

The study by Oertel et al.^[@R6]^ together with recent publications from other investigators^[@R7],[@R8]^ have begun to stimulate discussion about the


teachers would like to think, and the most recent generation is no exception. However, under child pornography statutes, it makes no difference if you‘re a teenager, or even if they‘re pictures of yourself. It‘s still a crime, and a number of teens have been brought up on felony sex offender charges just for having such photos stored on their phones. The Vermont legislature has recently introduced a bill that would legalize these photos as long as the participants are willing and between the ages of 13 and 18, hopefully bringing some much-needed sanity to this panic.

#2 – Bombing the Moon

THE TECHNOLOGY: NASA‘s LCROSS spacecraft, which blasted off in the general direction of the Moon this June, with a mission to confirm the presence of ice in the Moon‘sthe third generation Itanium processor (Madison), HP will offer Itanium-based servers from the low-end to the high-end of its product line, including HP NonStop Itanium servers. The HP servers will be augmented by features from the ProLiant IA-64 roadmap;

HP will continue with the previously published roadmaps for both PA-RISC and AlphaServer systems. HP will continue development of the PA-8800 and PA-8900 processors, as well as the EV7 and EV79 Alpha processors;

There are no changes to the previous Compaq NonStop server roadmap, except that it now will be known as the HP NonStop Server. The two planned MIPS processor upgrades and the transition to Itanium are on track.

Unix, Storage

HP and Compaq both offered Unix operating systems - HP-UX and Compaq Tru64 Unix. HP-UX will be the long-term Unix for


SAN FRANCISCO (KRON) — A simple one-bedroom apartment in San Francisco can cost more than $3,500 a month in rent.

That is why some people are choosing to live out of their vehicles instead.

On Friday night, KRON4’s Lydia Pantazes introduces us to a business owner, who calls his van his home.

Sandwiched between businesses and luxury apartments sits a brightly colored van decorated with hand-painted lions and flowers–and even inspirational quotes.

“People ask, ‘Well, what part of the city do you live in?’ and I’m like, ‘Well, I live in my van so home is where I park it, you know,'” Constantine Kosov said.

Kosov is a native San Franciscan, along with his dog Phoenix.

He calls his van Harry Peaches Vanderbeast.

“Certain people are like, ‘Oh my God. That’s so cool, like yourgoing to be interesting to see what kind of moral dilemmas the writers send our way.

“Are you going to make me cry?”

Yes. Based off Paweł Sasko’s response, the quests and stories are coming from someone that loves to make people cry, but in a good way. Just try to not to think about Jackie in the most recent cinematic trailer.

“Will there be high precision, high damage rifles, aka sniper rifles or DMRs and if yes, will there be opportunities to actually use the range and precision of those?”

CD Projekt confirmed that Sniper Rifles will be in the game in one form or another and revealed that they’ll fall into one of three main weapon categories. As we saw at E3 last year, each category vastly modifies the way


“interesting” solutions that might arise from regular initial conditions for charge and mass densities along with realistic pressure distributions. The motivations for this are to find compact charged fluid configurations that might represent realistic sources for the exterior vacuum Reissner-Nordström solutions. In particular one can ask whether it is possible to find realistic solutions for the extreme case where the total charge is equal to the total mass. A second motivation is to determine the possible end states for systems that have collapsed gravitationally but due to the repulsive nature of the electrostatic interaction are unable to form black holes and result in stable configurations.

The approach to be taken here is to write the Einstein-Maxwell system in curvature coordinates. The Einstein equations will yield three equations for twoconstructing a solution is as follows: ($i$) give the mass density and the charge aspect functions as explicit functions in the radial coordinate $r$; ($ii$) compute the mass aspect which leads to an explicit solution for the function $z(r)$; ($iii$) obtain a solution for the function $y(r)$ using the differential equation (7) or (8); ($iv$) finally solve for the pressure, $p(r)$ using equation (6).

The advantages to this procedure are that one can begin with a radial dependence that guarantees that some of the requirements that the solution be physically significant are met from the very beginning. Here it assumed that solutions for the conditions on the metric functions will follow if the input is physically motivated. Given that there will be two constants of integration associated with the


to ensure that it is concentrated at the outer edge of the sphere it is given as a simple power function: $$q=q_{2}r^{4}.  \label{q-eqn-r}$$ With these given, the first metric function we can solve for is $\lambda $. Using the substitution $z=e^{-\lambda }$, we have $$z=1-\frac{2M(r)}{r},$$ where the mass function $M(r)$ is given by $$M(r)=\frac{1}{2}\int\limits_{0}^{r}\left( \kappa \rho +\frac{q^{2}}{r^{4}}%
\right) r^{2}dr.  \label{big-M}$$ We integrate and obtain $$z=1-ar^{2}-br^{4}-cr^{6},$$ where $a$, $b$, and $c$ are constants:

$$a=\frac{1}{3}\kappa \rho _{0};  \label{a-cons}$$

$$b=\frac{1}{5}\kappa \rho _{1};  \label{b-cons}$$

and $$c=\frac{1}{7}\left( q_{2}^{2}-\kappa \rho _{2}\right) .$$

To solve for the second metric function we use the Einstein equations written as linear second-order differential equations for $y=e^{\nu /2}$. In particular, where subscripts denote derivatives with respect to the given variable, $$2r^{2}zy_{rr}+\left( r^{2}z_{r}-2rz\right) y_{r}+\left( rz_{r}-2z+2-4\frac{%
q^{2}}{r^{2}}\right) y=0.$$

A change of variable to $x=r^{2}$discrepancies are probably accounted for by differences between populations studied (including different levels of air pollution) and methods of case ascertainment. Literature is scant on the effect of air pollution on the development of TIA and minor stroke.

Air pollution is a modifiable risk factor and understanding the risks attributed to it would enable preventive health measures to be taken. In this study, we used an existing data set, the North West of England Transient Ischaemic Attack and Minor Stroke (NORTHSTAR) study of patients with TIA or minor stroke in the North West of England. Our hypothesis is that short-term changes in ambient air pollution are related to onset of TIA and minor stroke. The primary objective of the study is to investigate the effects on the onset of


comprises about 95% of oxides of nitrogen (NO~x~) from a combustion source \[[@B34]\]. Because of the high correlations among measured pollutants in the current study, it is difficult to separate their individual effects; however, NO may be associated with TIA and minor stroke more than the other pollutants as its effect persisted in a two pollutant model. However, we are unable to explain the contradictory negative effect of NO in Liverpool. Perhaps differences in the overall pollution profile and composition might be responsible for the observed effect. The biological mechanism by which NO might be associated with an increased risk of stroke or TIA has not been elucidated so far and there is little information from published literature. Various studies have linked NO~2~ to increased morbidity \[[@B18],[@B35]\], yetrelated substances like NO are uncommonly investigated in most epidemiological studies. Those few studies that have included NO as an exposure metric have highlighted its positive associations with the respective health outcomes \[[@B31],[@B36]\] as well as a higher correlation with UFP \[[@B36]\] which suggests that NO is an important pollutant to be considered in epidemiological studies.

NO, through a previously unrecognized mechanism, may be responsible for the observed association. NO is endogenously generated and involved in various regulatory and inflammatory functions of the vascular endothelium. It is possible that ambient NO influences bioavailability of endogenous NO. Inhibition of NO and the concomitant changes are known to contribute to essential hypertension, myocardial ischaemia, atherogenesis, thrombosis, insulin resistance and heart failure \[[@B37]\]. A few experimental studies have shown that exposure to


Attack and Minor Stroke study; O~3~: Ozone; OR: Odds ratio; PM~10~: Mass of particles with aerodynamic diameter less than 10 μm; SD: Standard deviation; SO~2~: Sulphur dioxide; TIA: Transient ischaemic attack; UFP: Ultrafine particles.

Competing interests
===================

All authors declare that they have no competing interests.

Authors' contributions
======================

GBB designed the study, collected air pollution data, planned and performed the statistical analyses and drafted the manuscript. CJS, PJT and RA contributed to the study design, interpretation of the results and preparation of the manuscript. CJS and PJT established the TIA and minor stroke cohort and provided the cohort data. AAH contributed to the interpretation of the results and preparation of the manuscript. All authors read and approved the final manuscript.

Supplementary Material
======================

###### Additional file 1

**Table S1.** Associations between ambient particulates and gases and TIAfor all study subjects: sensitivity analysis in a bilateral case-crossover strategy.

######

Click here for file

Acknowledgements
================

The original study was funded by the Sir Jules Thorn Charitable Trust. We thank Dr J Selvarajah and Sharon Hulme for their contribution to clinical data collection.


1. Introduction {#sec1}
===============

Chronic kidney disease (CKD) has been a significant health problem all over the world. It is a life-threatening disease frequently associated with hypertension, progression to renal fibrosis, and eventual renal failure \[[@B1], [@B2]\]. Prevention of CKD may improve renal damage and cardiovascular disease \[[@B2]\]. The therapeutic outcome of CKD remains unsatisfactory owing to the unclear understanding of pathological mechanisms \[[@B3]\]. Hypertension is a leading cause of kidney diseases by modulating interstitial fibrosis, glomerulosis, and mesangial cell growth. High blood pressure could raise hyperfiltration resulting in increase of proteinuria, activation of inflammatory signaling, and development of renal fibrosis \[[@B4]--[@B8]\]. Microinflammatory cytokines are expressed much more in patients with hypertension than in healthy people, suggesting that these cytokines were involved in the process of hypertensive renal damage \[[@B9]--[@B12]\].

Nuclearof Jiang Ya Yi Shen (JYYS) Granule {#sec2.1}
---------------------------------------------------

The JYYS granule was provided by Jiangsu Province Hospital of TCM (Nanjing, Jiangsu, China). The JYYS granule consists of*Bidens pilosa* Linn. (30 g),*Cornus officinalis* Sieb. et Zucc. (15 g),*Fallopia multiflora* (Thunb.) Harald. (12 g),*Scrophularia ningpoensis* Hemsl. (15 g),*Cyathula officinalis* Kuan (15 g), and*Alisma plantago-aquatica* Linn. (15 g). Each of these Chinese herbs was boiled with distilled water, and we got the extracts from the aqueous solution with ethanol. In the next step, the extracts were concentrated by freeze drying, which is the process of removing moisture from a frozen product in a vacuum. All the final crude products were mixed together and ground into powder. Finally, they were made into JYYS granule.

2.2. Collection of Clinical Patients {#sec2.2}
------------------------------------

Patients were selected for this study according to the criteria of


The fixed specimens were embedded in paraffin blocks, sectioned, and stained with hematoxylin and eosin (H&E staining). These sections were observed under a Carl Zeiss microscope (Axio Observer A1, Jena, Germany). For electron microscopy investigations, kidney tissues were fixed with 2.5% glutaraldehyde for 3 hours, rinsed in phosphate buffer saline (PBS), and fixed in 1% OsO4, dehydrated, and embedded in EPON. The sections were contrasted with uranyl acetate and lead citrate and photographed in a JEM-2100 transmission electron microscope.

The kidney sections were subjected to dewaxing in xylene and dehydration in graded ethanol. 3% H~2~O~2~ was used to block the activity of endogenous peroxidase for 10 min. Then, the sections were heated to 100°C in 0.1 M citrate buffer (pH 6.0) for 30 min to retrieve the antigens. These renal tissues wereMCP-1 in SHR. These data suggest that JYYS granule is a perfect therapeutic drug in hypertensive renal injury through modulating the NF-*κ*B activity and microinflammatory factors\' levels.

The SHR is the most widely used animal model of human essential hypertension and hypertensive renal injury. Hypertensive kidney damage of SHR occurs gradually with increasing age \[[@B35]--[@B37]\]. This whole process in SHR is similar to human hypertensive nephropathy \[[@B35]--[@B37]\]. In this study, SHR increased level of urinary albumin and *β*2-MG excretion and it also upregulated expression of profibrogenic genes and extracellular matrix genes compared with the WKY rats. JYYS granule has been a therapeutic drug for hypertension and early hypertension-caused renal damage by downregulating AngII and TNF-*α* level \[[@B32]\]. Extracts from*Bidens pilosa, Cornus officinalis, Fallopia multiflora, Cyathula officinalis*, and*Alisma plantago-aquatica* may


out the experiments. Bowen Yue, Dong Yan, and Shihai Yan analyzed the data. Zhuyuan Fang, Yuliang Qian, and Dong Yan contributed the reagents and materials. Dong Yan drafted the manuscript. All authors reviewed the final manuscript. Dong Yan and Bowen Yue contributed equally to this study.

![JYYS granule preserves renal function in SHR. Effects of JYYS granule on CCR, urinary albumin/creatinine, *β*2-MG/creatinine, and arteria caudalis pressure levels at the age of 24 weeks in SHR. (a) CCR. (b) Urinary albumin/creatinine. (c) Urinary *β*2-MG/creatinine. (d) SBP. (e) DBP. All data are expressed as mean ± SD, n=10, \#*P* \<0.05 versus WKY group, Δ\<0.05 versus SHR group.](ECAM2018-8472963.001){#fig1}

![JYYS granule mitigates histological changes of glomerular injury in SHR. (a) HE staining under light microscopy (×200): WKY group, SHR group, Benazepril group (SHR), JYYSof JYYS granule on renal fibrotic genes and extracellular matrix genes (n=10). (a) Collagen-I; (b) fibronectin; (c) PAI-1; (d) TGF-*β*1; (e) TIMP-1; (f) collagen-IV; (g) MMP-9. The values were normalized to the GAPDH values and then expressed as relative quantification. Data are expressed as mean ± SD, n=10, \#*P* \<0.05 versus WKY group, Δ\<0.05 versus SHR group.](ECAM2018-8472963.003){#fig3}

![JYYS granule decreases protein levels of renal profibrogenic genes and extracellular matrix decomposition in SHR. ((a) and (b)) Immunofluorescence (IF) was carried out to examine the effects of JYYS granule on renal TGF-*β*1, collagen-IV, MMP-9, and TIMP-1 expression; and the semiquantification of these genes was based on the fluorescence intensity. Data are expressed as mean ± SD, n=10, \#*P* \<0.05 versus WKY group, Δ\<0.05 versus SHR group. ((c) and (d)) Immunohistochemistry (IHC)


36.91±11.41              25.55±11.01^\#@^       37.92±12.16   30.77±10.76^*∗*^
  Alb (mg/L)       26.47±7.31               20.12±7.68^*∗*^        26.70±7.61    24.38±7.82
  *β*2-MG          0.42±0.10                0.28±0.10^\#@^         0.43±0.10     0.37±0.10

Abbreviation: NAG (N-acetyl-D-glucosamine), Alb (albumin), and *β*2-MG (*β*2-microglobulin). *∗P*\<0.05, ^\#^*P*\<0.01 versus pre-therapy in treatment group and placebo group; ^@^*P*\<0.05 versus post-treatment in placebo group.

######

Effects of    0.08±0.04*∗*

Abbreviation: RI (resistive index), PI (pulse index), AT (acceleration time), Vsmax (peak velocity of the systolic wave), Vdmin (minimum velocity of the diastolic stage), and Vm (mean velocity of the arterial blood). *∗P*\<0.05, ^\#^*P*\<0.01 versus pre-therapy in treatment group and placebo group; ^@^*P*\<0.05 versus post-treatment in placebo group.

[^1]: Academic Editor: Raffaele Capasso


Water is pumped from Brookport back into the Ohio River during flooding in 2011.PHOTO:Jim Hall

ADVERTISEMENT

Brookport Levee Among Those in Danger of Failing

By AP

NEW ORLEANS -

Seven years after Hurricane Katrina, inspectors are finding hundreds of levees - including the one in Brookport IL - in danger of failing in the US.

The U.S. Army Corps of Engineers hasn't yet rated about 40 percent of levees in the country, but of those it has inspected, some 326 are found to be in urgent need of repair.

Those levees cover more than 2,000 miles and are in every region and in cities and towns, such as Washington, D.C., Sacramento, Calif., and Brookport, IL.

The Associated Press requested, under the Freedom of Information Act, details on why certain levees were judged unacceptable and how manyline for Xo.”

Navedo, who is best known for her role on Jane, cut her teeth in acting in the mid-’90s on daytime soaps and has appeared on other TV shows, including three seasons of Law & Order. Navedo spoke with Vulture about what it means to play the kind of Latina character she dreamed of seeing on TV as a girl, what she thought of Xiomara’s pregnancy story line, and how she feels bossing Will Smith around on Netflix’s upcoming movie, Bright, now filming in Los Angeles.

What has playing Xo meant to you? What have you enjoyed about the role?

Gosh, there are so many things about her that I love. I really needed a show like Jane when I was growing up, so being able to portray a


up with, I’m more than happy and willing to do it.

What did you think of the pregnancy story line?

I’ll have to be honest: I was kinda bummed out that she got pregnant and she went and fooled around like that. I was like Eh, come on, I really want her to not make that decision. But she did. But I liked where they chose to go with it in terms of the pregnancy and the decision to have an abortion. I thought that it was an important thing to represent as another option. Not to preach to anyone that that’s how you should be living your life, but dealing with pregnancy has been shown in different ways on Jane the Virgin and this is just another way of[Laughs]. It was really cool to hang out with them.

You’re filming Bright for Netflix now. What can you tell us about your role as Captain Perez?

It’s a Netflix feature starring Will Smith and Joel Edgerton and it is a fantasy-action film that is super gritty, directed by David Ayer. Super real and down to earth. I play a police captain called Captain Perez, and I play Will Smith’s boss, actually. So yeah, it’s a good film with a lot of good messaging and fantasy. It also has Edgar Ramirez. I’m excited to have the opportunity to do something with them, but also do something different than Xiomara.

How do you like bossing Will Smith around?

I love it. It was a little nerve-wracking. I’ve never played someone in command like


of the position vector
let me call that rho which is equal to r sin
theta cos phi x plus sin phi y as you know
let us say it makes an angle in this particular
situation a phi with the x axis, under parity
it will go to the opposite direction with
phi here and what is the angle that minus
rho makes with x axis it is pi plus phi.
So, that is what you have here. And what about
Y l m theta phi? How does it go? To what does
it go into under parity?
Just note that this is proportional to Legendre
polynomial; associated Legendre polynomial
as a function of cos theta and exponential
i m phi. These are the phi and theta dependence
of the spherical polar coordinates; spherical
harmonics Y l m. And the azimuthal angle under
paritygoes to pi plus phi and e power i m
phi will go to e power i m phi plus pi under
parity of course, which is equal to e power
i m; let me write it as i pi m e power i m
phi, which is equal to minus 1; e power i
pi is minus 1; power m e power i m phi. There
is a factor of minus 1 power m that the e
power i m factor i m phi factor picks up for
the azimuthal part of the wave function picks
up.
What about the polar angle part under parity,
it will go to P l m with cos theta; cosine
of pi minus theta now and without going into
analyzing it we will just give you the result
it is equal to minus 1 over


state; which in
other ways says that K 0 is a particle which
cannot be assigned a proper parity to the
one or the other way to interpret it is that,
parity is not conserved in such decays. It
can be gained do positive or negative verities
there was also observation of similar; the
particle K plus going into pi plus pi 0 or
going into pi plus pi minus pi plus. 3 pions
and 2 pions.
Again, one final state is, even parity the
other one is odd parity. In fact, historically
speaking initially these particles were thought
of to be 2 different particles, because parity
was violated in the final state. Or, they
decay into 2 different final states with 2
different final parities. But then it was
suggested by T D Lee and C N Yang that parity
is actually parity could bequark
with the w plus now, because u has a charged
2 by 3 go into d with charge minus 1 by 3
plus w plus 1. So, that charges are added
up properly, correctly. This will go into
positron, when a positron goes out we put
the arrow in the opposite direction. So, it
is e plus and nu e.
So, positron takes away the charge which is
the w plus brings to that second vertex. So,
w plus goes to e plus plus nu e. So, we have
another gauge boson w plus. So, weak; there
are 2 weak gauge bosons now. W plus and w
minus it turns out that one is the antiparticle
of the other.
Then you will see that; for the theory to
be consistent when we discuss the theoretical
model it will be clear we need another neutral
weak