multiple extrinsic factors to determine the differentiation fate of MSC. (b) Differential evolution (DE) used as the search algorithm in this project. Each color represents the concentration of each of the seven extrinsic factors, selected from a scale ranging from 1 to 10 or 0 to 12. The combination of these factors resulted in 10^7^ (10 million) or 13^7^ (62.7 million) theoretical combinations in the present study.](srep03420-f1){#f1}

![FSC-DE with ALP assay.\
(a) Effect of prospective drug cocktails identified with FSC-DE with ALP assay from 10 million potential candidates for the osteoblastogenesis of D1 cells. The prospective cocktails did not induce *in vitro* mineralization, despite high ALP activity. (b) Correlation between doses of extrinsic factors in each drug cocktail elicited and used in FSC-DE with ALP assay against ALP expression inexercising its inherent contempt power in the face of a presidential assertion of executive privilege.”

White House Press Secretary Sarah Sanders also blasted House Democrats in a statement Monday.

“[B]ased on longstanding, bipartisan, and Constitutional precedent, the former Counsel to the President cannot be forced to give such testimony, and Mr. McGahn has been directed to act accordingly,” Sanders said in a statement on Monday.


india

Updated: Sep 26, 2019 01:33 IST

A Delhi court on Wednesday dismissed the bail application of Congress leader DK Shivakumar, arrested by the Enforcement Directorate (ED) in connection with a money laundering case. The court said the investigation in the case was still in the initial stage.

Rejecting the bail plea, special Judge Ajay Kumar Kuhar said, “In course of arguments, the ED has produced documents, like the list of 317 bank accounts and other documents of properties, which show that the investigation is at the crucial stage of examining the documents and their nexus with the assets of the applicant/accused.”

Shivakumar’s counsel Mayank Jain said, “We are not satisfied with today’s judgment and we would challenge it in the Delhi High Court,” Jain said.

The court said the apprehension of theConcurrent chemoradiotherapy with paclitaxel and nedaplatin followed by consolidation chemotherapy in locally advanced squamous cell carcinoma of the uterine cervix: preliminary results of a phase II study.
To evaluate the efficacy and toxicities of concurrent chemoradiotherapy (CCRT) and consolidation chemotherapy in patients with locally advanced squamous cell cervical carcinoma. Patients with LASCC (FIGO Stage IIB-IIIB) were treated with pelvic external beam radiotherapy (45 Gy for Stage IIB and 50 Gy for Stage III) and high-dose-rate intracavitary brachytherapy (50 Gy for Stage IIB and 35 Gy for Stage III). The cumulative dose at point A was 50 Gy for Stage IIB and 65 Gy for Stage III. Concurrent chemotherapy with paclitaxel (35 mg/m(2)) and nedaplatin (20 mg/m(2)) was given every week for 6 weeks. Consolidation chemotherapy with paclitaxel (135 mg/m(2))


can be classified by etiology and epilepsy syndrome. Prognosis is favorable in the majority of cases. However, the apparent syndrome may change with longer follow-up. The ability to classify these cases early in the clinical course is important if they are to be used for prognostic purposes.fiery autmnal leaves of the New England countryside in my own classic roadster, wearing only large sunglasses, a blazing red satin cocktail dress that hugs my curves as tightly as I’m hugging the road’s, and diamond-encrusted stilettos that are both elegant and forceful as they alternate pumping the clutch and the gas. My pelvis tightens as I breeze through the winding turns, careful not to careen too far and laughing wickedly as I balance the eternal rush between thrill and danger.

… I imagine I’m a painter working in a studio atop a city skyscraper, painting on canvases the curves of beautiful women who are lounging around the loft while smoking and eating tropical fruit amidst swirls of incense. I am covered in splotches of paint, despite wearing an


[Association between Vibrio cholerae and zooplankton of estuaries of São Marcos Bay/São Luis - MA, Brazil].
This study was carried from October 1997 to October 1998 with the purpose of investigating the link between the species Vibrio cholerae and zooplankton in the estuaries of rivers Anil and Bacanga in São Luis, Maranhão. Research of viable but non culturable forms of Vibrio cholerae O1, and analyze the correlation between pH values, salinity and water temperature with the presence of bacteria in zooplankton samples. The traditional method of cultivation and fluorescent antibody technique were applied to detect the bacteria. A total of 52 samples of zooplankton were collected. There was a predominance of Copepoda. The culture enabled 55 isolates of Vibrio cholerae non-O1. The serogroups O1 and O139 were identified inEnjoy Our Free Return Shipping

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before.

G7 allies seemed as perplexed as Canada at the sudden diplomatic row, and Germany and France accused Mr Trump of destroying trust and acting inconsistently.

Having left the G7 summit in Canada early, Mr Trump's announcement on Twitter that he was backing out of the joint communique torpedoed what appeared to be a fragile consensus on a trade dispute between Washington and its top allies.

Mr Trump also said he might double down on import tariffs by hitting the sensitive auto industry, throwing the G7's efforts to show a united front into disarray.

"In a matter of seconds, you can destroy trust with 280 Twitter characters," German Foreign Minister Heiko Maas said when asked about Mr Trump's U-turn, adding it would take much longer to rebuild lost trust.

Sorry, this video hasDownload the full poll Most computers open these documents automatically, but you may need Adobe Reader. Download the reader here

There was very strong support for a referendum on further integration with the European Union. When asked if the British people should decide in a vote before Britain transfers any further power to the European Union 84% agreed, with 13% against. Please turn on JavaScript. Media requires JavaScript to play. The poll was conducted for BBC2's Daily Politics programme by ComRes. They spoke to 1,004 voters between the 13th March and 16th March. Full Results: 1. The current economic crisis has made me more likely to support Britain joining the Euro Agree- 31% Disagree- 64% 2. Britain benefits overall from membership of the European Union in terms of jobs


of the Interfraternity Council. He was a fourth year, from Atlanta, and very kind to me. But he couldn’t do anything for me.

I made as much noise as I could have, but no one heard me. Until 2005.

That young man in the glasses had a name: William Beebe. I knew because I rifled through his mail that terrible October morning. In September 2005, Beebe wrote a letter to my home to apologize. It became a firestorm of inexplicable proportions.

From September through November 2005, I corresponded with him via email to find out what had happened to me that night. How many attackers? He wrote that he was the only one. What was in my drink? He didn’t know. Why did he rape me? He thought it was ainvestigation proceeds, and to continuing to work with the relevant law enforcement authorities,” said Black, CSIO of Citrix.

Hacker Tactics

As per FBI, the hacker used a tactic known as password spraying and credential stuffing. Password spraying is a technique used for a cyber attack against a weak password to compromise the first level of security and then move ahead to break the additional security layer. Credential stuffing involves stealing a password from data dumps and using them to access other services compromising the security and services. This way hackers managed to access and download the sensitive files.

Post Investigation Report

Based on the investigation, Citrix confirmed that hackers had intermittent access to the company’s network between 13-October-2018 to 08-March-2019 and they have removed files from the Citrix internal system. Stolen data


reinstatement and back pay. The petition alleged that Gately had been a senior management employee under section 45108.5, subdivision (a)(2), and as such, her three-year employment contract had been automatically renewed when she was not notified of its termination 45 days before it expired on June 30, 2004. The petition also alleged that the layoff based on lack of work and lack of funds was pretextual, and that she had actually been terminated for disciplinary reasons without receiving notice and an opportunity to be heard. The trial court denied the petition and issued a statement of decision that concluded Gately was not a senior management employee, because she had not been designated as such by Board. The statement of decision did not address the legality of the layoff.This appeal follows.

DISCUSSION

Senior Management Status
Gately contends she was a "senior management" employee who was entitled to a renewal of her three-year contract unless District gave her notice it was terminating that contract at least 45 days before its expiration. District responds that under the Education Code, a classified employee does not fall within the category of senior management unless a school board confers this status by a formal vote, something that was never done in Gately's case. Having independently reviewed the trial court's resolution of this issue, which depends on the interpretation of the relevant statutes and the application of the law to undisputed facts, we reject Gately's claim. (See Coburn v. Sievert (2005) 133 Cal.App.4th 1483,1492, 35 Cal.Rptr.3d 596; Walker v. Allstate Indemnity Co. (2000) 77 Cal.App.4th


senior management position." (Italics added.) Section 45108.5 provides: "(a) Senior management employee means either of the following: [¶] (1) An employee in the highest position in a principal district program area, as determined by the governing board, which does not require certification qualifications, and which has districtwide responsibility for formulating policies or administering the program area. [¶] (2) An employee who acts as the fiscal advisor to the district superintendent. [¶] (b) The maximum number of positions which may be designated as senior management positions shall be as follows: [¶] (1) For districts with less than 10,000 units of average daily attendance, two positions; [¶] (2) For districts with 10,000 to 25,000 units of average daily attendance, inclusive, three positions...." (Italics added.)
Section 45100.5 authorizes a district school boardQ:

Using git and subversion code within a Bazaar project

I'm planning on tracking source with bzr but will be needing to include some clones and checkouts of other projects mine depends on.
Is there any advice beyond simply adding their directories to an ignore file and moving on?

A:

You can check out the git and svn branches with Bazaar into the appropriate directories (using the bzr-svn and bzr-git plugins). Then you can update or push everything in one go using the bzr-externals plugin.
But if you just wanted to manually use git and svn then yeah check it out with those tools and ignore the directories.


polymerase\'s largest subunit, Rpb1, and is composed of a tandem array of seven amino acid repeats with the consensus sequence Y~1~S~2~P~3~T~4~S~5~P~6~S~7~. The number of these heptad repeats varies from organism to organism and appears to correlate with genomic complexity; there are 26 repeats in yeast, 44 in *Drosophila*, and 52 in humans \[[@B3], [@B4]\]. Despite being dispensable for the catalytic activity of RNAPII, the CTD is conserved through evolution and is essential for life; for example, removing two thirds of the CTD repeats results in inviability \[[@B5], [@B6]\]. Although the function of the CTD remained elusive for several years after its discovery, research over the last three decades has confirmed its role as a selective and flexible scaffold for numerous factors involved in transcription (for reviews see \[[@B2],(Figures [1(a)](#fig1){ref-type="fig"} and [1(b)](#fig1){ref-type="fig"}). However, this revised model is still an oversimplified representation of a complex process and should be viewed as such.

3. Other Post-Translational Modifications of the CTD {#sec3}
====================================================

Lastly (in terms of complications), it has not escaped notice that modification of the CTD is not theoretically limited to the phosphorylation of Ser2, Ser5, and Ser7. Many other post-translational modifications have been observed, including phosphorylation of Tyr1 \[[@B21]\] and Thr4 \[[@B22]\] and glycosylation \[[@B23]\]; however, the extent and transcriptional functions of these modifications are currently unknown (for more discussion, see \[[@B8]\]). These "noncanonical" modifications, once fully characterized as functionally significant, have the potential to expand the CTD code further and redefine aspects of the general model; Ser7, a relative newcomer to the general paradigm, is a good example


CTD-related functions and a short list of new developments.

Providing the first clear link between the CTD and histone modification, the yeast Set1 and Set2 methyltransferases were found to be recruited to actively transcribed genes at specific stages of the transcription cycle (5′ end versus interior of the gene, resp.) through interactions with the Ser5P (via the PAF complex for Set1) and Ser2/5P CTD \[[@B120]--[@B123]\] (see \[[@B124]\] for a review). Thus, Set1\'s activity, the methylation of histone H3 at the K4 position, peaks near the promoter, while Set2\'s methylation of H3 at K36 occurs downstream in the coding region. The H3K36 trimethylation mark can be used to identify transcriptionally active genes and has been shown to suppress inappropriate transcription from cryptic promoters, which was initially thought to occur through {
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      thisVolume = Send(self,@CalculateVolume,#who=who,
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      if thisVolume < oldVolume
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         Send(oRoom,@SomeoneSaid,#type=SAY_MESSAGE,#string=jala_song_failed,
              #what=self);


The Bharatiya Janata Party (BJP) on Thursday lashed out at Rahul Gandhi fro targeting the Rashtriya Swayamsevak Sangh (RSS) and alleged that an 'immature' Congress vice-president was performing an item number and entertaining his party's youth with such a childish remark.

"It is very immature of Rahul Gandhi to make comments on a nationalistic organization like the RSS. He is obviously performing an item number before his party youth and is trying to entertain them with such childish remark," BJP spokesperson GVL Narasimha Rao told ANI.

Speaking at an NSUI convention in the national capital earlier, Gandhi targeted the RSS for its influence over the BJP.

"Look at RSS cadres. They always stand in a straight line, and if anyone steps even a little out of line, they get caned. DisciplinePress "Call free!" and select "Call" from the Skype menu. If you are not using a headset or a microphone to make a call, you have to press the "Mute" button before making the call to use the dial pad. You need the dial pad (press "Show dial pad") to navigate your way to speaking with a representative. After you have reached the representative, press the "Mute" button again to speak. Smartphone and tablet users should follow the same procedure.

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away.

"What we've achieved is a significant advance for this technology and suggests whole new areas for research - we haven't solved all the problems inherent to this chemistry, but our results do show routes forward towards a practical device," said Professor Clare Grey of Cambridge's Department of Chemistry, the paper's senior author.

Many of the technologies we use every day have been getting smaller, faster and cheaper each year - with the notable exception of batteries. Apart from the possibility of a smartphone which lasts for days without needing to be charged, the challenges associated with making a better battery are holding back the widespread adoption of two major clean technologies: electric cars and grid-scale storage for solar power.

"In their simplest form, batteries are made of three components: aWITH PASSWORD = '<you_could_use_masetr_key_instead_of_p@55w0rD5>';
go
-- destroy the private key
ALTER CERTIFICATE [signing_cert] REMOVE PRIVATE KEY;
go

-- Create a user for the certificate & grant it all the permissions you would need for running teh SP
CREATE USER [signing_cert] FROM CERTIFICATE [signing_cert];
go
GRANT ALTER ON [myTable] TO [signing_cert];
go

-- Permission check will be OK for the low privileged user
-- You control what this user is allowed to do via SPs
EXECUTE ( 'EXEC [dbo].[sp_truncate_my_table];' )AS USER = 'low_priv_user';
go

As you can see, I created a module that allows the caller to call TRUNCATE on a table, without granting ALTER permission directly to the user.
Ideally, when using this mechanism you would like to follow the least-privilege principle, and grant only the permissions you require and nothing else; but if you are having trouble finding the exact permissions you


A group of researchers led by Edgar Gomes, Group Leader at Instituto de Medicina Molecular João Lobo Antunes (iMM; Portugal) identifies in muscle cells a new mechanism that activates locally the movement of the nucleus to its correct position. This discovery, published in the scientific journal Developmental Cell, can have important implications in therapeutic strategies to treat muscular diseases.

A hallmark of muscle cells is the unique position of their nuclei at the cellular periphery. In multiple muscle diseases, as a result of aging, sports injuries, or genetic disorders this nuclear positioning fails to occur. Consequently, patients experience a gradual loss of muscle function that leads to a loss of autonomy.

"We have previously shown the molecular mechanisms used by muscle cells to move their own nucleus to the correctat the hotel for a two day conference and from Melissa at the front desk to the housekeeping staff asking if we had a pleasant stay and hoped to see us again, the service was typical of the warmth and genuine care for guests that exemplifies the east coast hospitality. We will certainly return.

Stayed: June 2012, travelled on business

Value

Location

Sleep Quality

Rooms

Cleanliness

Service

Ask famtimeOntario about Delta Hotels Barrington

Thank famtimeOntario

This review is the subjective opinion of a TripAdvisor member and not of TripAdvisor LLC

Management response:Responded 28 June 2012

Greetings from Delta Barrington,

Thank you for taking the time to share feedback with us. We appreciate you choosing us on your recent visit. I will be sure to include Melissa and all team members on your post. We believe our service levels and hospitality sets


to the most popular destinations in the city via the pedway system, and delight in our perfect location near Casino Nova Scotia, Scotiabank Centre and more....more less

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Own or manage this property? Claim your listing for free to respond to reviews, update your profile and much more.research methods, and research leadership and grant writing strategies. The PI's long-term career goal is to become a recognized leader and innovator in patient-oriented research in the field of cardiovascular (CV) disease prevention. In the medium- term, her goal is to become an independent, R01-funded investigator contributing to the development of novel approaches to CV disease risk assessment, risk communication, and primary and secondary prevention. For the short-term, this proposal outlines clear training and research objectives which will be achieved through structured learning, including courses and workshops, and further hands-on research apprenticeship with an outstanding team of highly accomplished, extramurally-funded mentors and advisors. Attainment of these objectives will be a crucial stepping-stone for Dr. Gore's future success as independent investigator. ENVIRONMENT: The PI works at one the top


undiagnosed in more than one third of cases, reflecting an important detection gap in the community. To help close this gap, the PI completed and published a two-phase pilot study screening blood donors, in collaboration with the largest independent blood program in Texas. The research proposed in this K23 is a logical continuation of this published work, and aims to (Aim 1) Characterize cardiometabolic risk factor prevalence, awareness and control among participants in a community blood center health screening program, including comparisons with relevant data from established local (Dallas Heart Study) and national (NHANES) probability-based population cohorts; (Aim 2) Develop, pre-test and optimize a multi-component, multi-platform, proactive communication strategy to deliver screening test results, aiming to increase cardiometabolic risk factor awareness and control in blood donors; (Aim 3)Errors in the interpretation of Mohs histopathology sections over a 1-year fellowship.
Errors can occur in the interpretation of Mohs histopathology sections. Errors in histology interpretation can lead to incomplete removal of cancer and cancer persistence or the unnecessary removal of uninvolved tissue. Extensive proctored training is necessary to reduce these errors to an absolute minimum level. To analyze and quantify the number of cases and the amount of time required to reach a satisfactory level of expertise in the reading and interpretation of Mohs histopathology. A single-institution pilot study was designed to track errors in the interpretation and mapping of Mohs histopathology sections. A Mohs surgery fellow independently preread Mohs cases and rendered his interpretation on the Mohs map. One of the Mohs program directors subsequently reviewed and


combined treatment is indicated, selected individually by means of diagnostic oesophageal stimulation. The authors consider the described method due to its innocuous and repeatable character as the method of choice for optimization of antiarrhythmic treatment of supraventricular dysrhythmias.E-Cigarette Vapor Induces an Apoptotic Response in Human Gingival Epithelial Cells Through the Caspase-3 Pathway.
Electronic cigarettes represent an increasingly significant proportion of today's consumable tobacco products. E-cigarettes contain several chemicals which may promote oral diseases. The aim of this study was to investigate the effect of e-cigarette vapor on human gingival epithelial cells. Results show that e-cigarette vapor altered the morphology of cells from small cuboidal form to large undefined shapes. Both single and multiple exposures to e-cigarette vapor led to a bulky morphology with large faint nuclei and an enlarged cytoplasm. E-cigarette vapor also increased L-lactate dehydrogenase (LDH) activity in the targeted cells. This activity was greater with repeated exposures. Furthermore, e-cigarette vapor increased apoptotic/necrotic epithelial cell percentages compared to that observed in the control. Epithelial cell


Q:

Security assessment between $g^{a_ix_i+r_i}$ and $g^{x_i+r_i}$

Imagine a tagging system whose security requirements imply to learn nothing from the tag about the encoded value.
We consider a plaintext space $X \in \mathbb{Z}_p$ and a group $\mathbb{G}$ where the DLP is computationally hard.
The sender sends $\sf{tag_1}=g^x_i$ where $g$ is a generator of $\mathbb{G}$. This is not really secure in the sense that we provide the attacker an oracle to verify its guess on values in $X$.
We change the tag to be of the form $\sf{tag_2}=g^{x_i+r_i}$ where $r_i$ is a random value from $\mathbb{Z}_p$
We consider another tagging scheme where $\sf{tag_3}=g^{a_ix_i+r_i}$ where $a_i, r_i$ are random values from $\mathbb{Z}_p$
Is $\sf{tag_3}$ more secure than $\sf{tag_2}$? Is there an attack in $\sf{tag_2}$ which is mitigated with $\sf{tag_3}$?

A:

It is not entirely clear whatjust guess $x_1$ and test as in the first construction. Clearly, if there is more than one tag you can also test by cancelling out $g^{\sum r_i}$ from the aggregate of all tags, but the sum $x_1+\ldots+x_n$ in the remaining value $g^{\sum x_i}$ may not be unique anymore (so it depends if the $x_i$ can only take some specific values - then your sum could be unique but it must not be the case).
Thrid Construction
For the third approach with tags of the form $g^{a_ix_i +r_i}$: If the value $a_i$ is uniformly at random chosen by every user, then even when publishing $g^{\sum r_i}$ this will not give an advantage for testing, as even when cancelling out $g^{\sum r_i}$ in the full aggregate of all tags you still


The effect of tear depth on the propagation of aortic dissections in isolated porcine thoracic aorta.
An in vitro model was used to determine the influence of tear depth on the propagation pressure of aortic dissections. Saline was injected into the media of segments of 20 porcine thoracic aortas to create blebs. A circumferential slit was made on the intimal side of each bleb, connecting the true lumen to the false lumen. Each aorta was then pressurized under no-flow conditions until propagation in either the anterograde or retrograde direction occurred. Histological sections of each principal propagating edge were used to determine depth of tear, measured as the ratio of elastin layers in the intimal flap to the elastin layers in the intact wall. Propagation occurred for tear depths rangingprojected subspaces only. Currently the best practical algorithms are the BKZ algorithm (Schnorr and Euchner \[[@CR32]\]) and the recent self-dual SDBKZ variant by Micciancio and Walter \[[@CR21]\] (called DBKZ there). On the other hand, the best theoretical guarantees for block algorithms are provided by the (at currently practical block sizes apparently inferior) slide reduction algorithm of Gama and Nguyen \[[@CR11]\].

In this paper, the approaches of Hanrot et al. \[[@CR14]\] (used also in Micciancio and Walter \[[@CR21]\]), Schnorr \[[@CR31]\], and Gama and Nguyen \[[@CR11]\] for the asymptotic worst-case analysis of LLL, BKZ, and SDBKZ are improved. The first improvement replaces the complicated dynamical system arguments of \[[@CR14]\] by simpler and sharper induction arguments on a bound on the bit sizes. The second improvement is an analysis of a greedy


multiplicative way.

Basic notions {#Sec2}
=============

This section provides basic definitions together with a collection of mostly well-known results put together in a form useful for the subsequent development. In view of further applications to be reported elsewhere, some of the results are presented in slightly greater generality than needed in this paper.

The bit profile {#Sec3}
---------------

A **lattice** of **dimension** *n* is a nonempty subset $\documentclass[12pt]{minimal}
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                \setlength{\oddsidemargin}{-69pt}
                \begin{document}$$B\in \mathbb {R}^{m\times n}$$\end{document}$ has rank *n* then ([1](#Equ1){ref-type=""}) defines a lattice


 \begin{document}$$g_0=0$$\end{document}$.

The **dual lattice** $\documentclass[12pt]{minimal}
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                \begin{document}$$y^Tx$$\end{document}$ is integral for all $\documentclass[12pt]{minimal}
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                \begin{document}$$k\hbox {th}$$\end{document}$ **block** $\documentclass[12pt]{minimal}
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                \begin{document}$$B_{k:k+s-1}$$\end{document}$ against the basis vectors in $\documentclass[12pt]{minimal}
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                \begin{document}$$g_1$$\end{document}$ we can recover$$\documentclass[12pt]{minimal}
                   \usepackage{amsbsy}
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                \begin{document}$$k<m$$\end{document}$ then$$\documentclass[12pt]{minimal}
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 \usepackage{amssymb}
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                \begin{document}$$\begin{aligned}&\displaystyle 0\le g_k-g_k'\le \max _{\ell =0:s-1}(a_{k+\ell }-a_k). \end{aligned}$$\end{document}$$ (ii)Upon dual reduction of a block $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
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                \begin{document}$$\mathbb {R}^n$$\end{document}$. In particular, the median of $\documentclass[12pt]{minimal}
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     \usepackage{amsfonts}
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                \begin{document}$$(n-1)/(\gamma (B)-1)$$\end{document}$ is$$\documentclass[12pt]{minimal}
                \usepackage{amsmath}
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                \begin{document}$$B^{k-s+2:k+1}$$\end{document}$ with bit sizes derived from ([3](#Equ3){ref-type=""}). $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}
                \usepackage{amsfonts}
                \usepackage{amssymb}


          \begin{document}$$\begin{aligned} R(B):=H(B)^{1/n} \end{aligned}$$\end{document}$$of a basis *B*. (Using the $\documentclass[12pt]{minimal}
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                \begin{document}$$a(g_{1:m})$$\end{document}$ the **effective approximation exponent**. By definition, we still have$$\documentclass[12pt]{minimal}
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         \begin{document}$$\Vert b_i\Vert \ge \Vert b_i^*\Vert $$\end{document}$ we see that $\documentclass[12pt]{minimal}
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                \begin{document}$$\begin{aligned} h(g)\le \mu _s,~~~\widetilde{a}_{n-s+1}(g) \le 2\mu _s, \end{aligned}$$\end{document}$$appropriate since for a slide reduced basis *B*, the block $\documentclass[12pt]{minimal}
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                \begin{document}$$B^{k:k+1}$$\end{document}$ changes the bit profile to $\documentclass[12pt]{minimal}
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                \usepackage{upgreek}
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                \begin{document}$$i=k$$\end{document}$. Moreover,(i)$\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}
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  \begin{document}$$g_k$$\end{document}$ can be reduced only finitely often by at least $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
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                \begin{document}$$>\delta $$\end{document}$, hence the reduction will be performed. Therefore no such *k* exists after convergence. This proves ([35](#Equ35){ref-type=""}). ([36](#Equ36){ref-type=""}) follows since $$\documentclass[12pt]{minimal}


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                \usepackage{upgreek}
                \setlength{\oddsidemargin}{-69pt}
                \begin{document}$$\begin{aligned} A(g)=\frac{n-1}{2}g_n+\sum _{j=1}^{n-1}j(n-j)c_{j+1} \end{aligned}$$\end{document}$$ by substituting the definition of the $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
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                \begin{document}$$c_i$$\end{document}$ into the sum and simplification. Since $$\documentclass[12pt]{minimal}
                \usepackage{amsmath}
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    \setlength{\oddsidemargin}{-69pt}
                \begin{document}$$g_k/\delta $$\end{document}$ times. Hence the total number $\documentclass[12pt]{minimal}
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 (Smeets \[[@CR34], p.11\]).

Storjohann \[[@CR36], p. 13\] suggested to perform each Lagrange step on the block $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
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              \begin{document}$$\begin{aligned} \Delta _k:=\min \{c_k-2\Gamma _k,(k+1)g_k-kg_{k+1}\}, \end{aligned}$$\end{document}$$where $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
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         \usepackage{amsbsy}
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                \begin{document}$$\Delta _k<\Delta $$\end{document}$, where $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}
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        \usepackage{mathrsfs}
                \usepackage{upgreek}
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                \begin{document}$$\begin{aligned} p^{{{\text{ init }}}}\le p^{\max } =\left\{ \!\! \begin{array}{cc} \displaystyle \sum _{j=1}^{n/2} 4j(2j-1)\beta _{2j-1} &{} (n\, \hbox {even})\\ \displaystyle \sum _{j=1}^{(n-1)/2} 4j(2j+1)\beta _{2j} &{} (n\, \hbox {odd})\end{array}\!\!\right\} \le \frac{n(n+2)(4n+1)}{3}(\beta +O(\lg n)). \end{aligned}$$\end{document}$$The following theorem shows that a special greedy LLL algorithm has a marginally better complexity than the cyclic LLL algorithm of Hanrot et al. \[[@CR14]\], and at the same time gives stronger guarantees for the resulting reduced basis. (Hanrot et al.             \usepackage{amsfonts}
                \usepackage{amssymb}
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                \setlength{\oddsidemargin}{-69pt}
                \begin{document}$$\begin{aligned} \min (c_i-2\Gamma _2,p_i)=\Delta _i\le 2(\Gamma -\Gamma _2) ~~~\text{ for } i=1,\ldots ,n-1. \end{aligned}$$\end{document}$$Therefore ([34](#Equ34){ref-type=""}) implies$$\documentclass[12pt]{minimal}


            \usepackage{amsfonts}
                \usepackage{amssymb}
                \usepackage{amsbsy}
                \usepackage{mathrsfs}
                \usepackage{upgreek}
                \setlength{\oddsidemargin}{-69pt}
                \begin{document}$$\begin{aligned} p-p'=p_k. \end{aligned}$$\end{document}$$ **Case 2** $\documentclass[12pt]{minimal}
              \usepackage{upgreek}
                \setlength{\oddsidemargin}{-69pt}
                \begin{document}$$N_{\text{ tot }}=O(n^3\log (1+\beta /n^2))$$\end{document}$.

A basis is LLL reduced in the traditional sense if the second alternative in ([45](#Equ45){ref-type=""}) holds for all *k*. This is guaranteed by our theorem only when no final $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}
                \usepackage{amsfonts}


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                \usepackage{upgreek}
                \setlength{\oddsidemargin}{-69pt}
                \begin{document}$$p_k$$\end{document}$ indicate a temporary barrier for reduction, which may or may  \setlength{\oddsidemargin}{-69pt}
                \begin{document}$$\mu >\mu _s$$\end{document}$ then at the end of the dual tour following the computation of $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}
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                \usepackage{amsbsy}


\usepackage{wasysym}
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                \usepackage{upgreek}
                \setlength{\oddsidemargin}{-69pt}
                \begin{document}$$\lceil Nt\rceil $$\end{document}$ tours by a factor of at least $\documentclass[12pt]{minimal}
  Hanrot et al. is able to bound the approximation exponent or the enumeration exponent. In particular, unlike BKZ (where Schnorr \[[@CR30]\] gives bounds on the approximation exponent) and slide reduction, SDBKZ is (at present) not guaranteed to find a very short vector in case that $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}
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        \setlength{\oddsidemargin}{-69pt}
                \begin{document}$$\le $$\end{document}$−0.20760.16670.16670.150.14720.14290.14290.0870 Table 2Best known upper bounds on Hermite constants

The best asymptotic upper bound known is (according to Conway and Sloane \[[@CR7], p.20\])$$\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}
                \usepackage{amsfonts}
                \usepackage{amssymb}
                       \usepackage{wasysym}
                \usepackage{amsfonts}
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                \begin{document}$$\frac{1}{7}$$\end{document}$ in ([65](#Equ65){ref-type=""}) is


#include "aquila/global.h"
#include "aquila/source/SignalSource.h"
#include "aquila/source/Frame.h"
#include "aquila/source/FramesCollection.h"
#include "UnitTest++/UnitTest++.h"
#include <algorithm>

bool equalSamples(Aquila::Frame frame, Aquila::SampleType arr[])
{
    return std::equal(std::begin(frame), std::end(frame), arr);
}

SUITE(FramesCollection)
{
    const int SIZE = 10;
    Aquila::SampleType testArray[SIZE] = {0, 1, 2, 3, 4, 5, 6, 7, 8, 9};
    Aquila::FrequencyType sampleFrequency = 100;
    Aquila::SignalSource data(testArray, SIZE, sampleFrequency);

    TEST(Empty)
    {
        Aquila::FramesCollection frames;
        CHECK_EQUAL(0u, frames.getSamplesPerFrame());
        CHECK_EQUAL(0u, frames.count());
    }

    TEST(EmptyWhenZeroSamples)
    {
        Aquila::FramesCollection frames(data, 0);
        CHECK_EQUAL(0u, frames.getSamplesPerFrame());
      file is created we update
our cache, whenever you delete a file in your dropbox it will be deleted from
our cache.

> How do I remove my account? Is all my data deleted as soon as I remove the
> Dropbox connection?

You can select and delete all folders from the websrvr app folder to delete
the data from our servers. Once you do that, you can unlink your dropbox
account from the dropbox website at
[https://www.dropbox.com/account#security](https://www.dropbox.com/account#security)

> And of course the pricing questions: Is it free, will it stay free? Are
> there usage restrictions? (Bandwidth, traffic, etc)

websrvr backed hosting: $1 per month - All the data would be served from our
fast web servers

Amazon S3 backed hosting: $3 per month - All the data would be served from
Amazon S3 servers.

Amazon Cloudfront backed hosting: $10 per month


Buying a Bunch of Stuff: #LewisLetters #001 (Sean)

This is the first entry in our new feature, The #LewisLetters, notes written to and from me and my wife, @mackey4saw!

These posts will be written in RocketBook Wave “smart” notebooks, and this first one is about RocketBook Wave notebooks, and if the people at Rocketbook want to give us a sponsorship for creating a feature using and endorsing their product, well, we can’t stop them! ~Sean

Okay, I’m probably not f***ed, but she is going to make fun of me for putting an apostrophe in “see’s.”

Thanks for reading!

~Sean Lewis

Sharing our posts REALLY helps us out (our advertising budget is $0). If you liked what you read, please give us 30 seconds of your valuable time and hit one of these buttons.The present invention relates to crawler tractor tracks and more specifically relates to sealed pivot or hinge joints between track link links.
A primary problem area in current crawler track design is the lack of durability in the track link pivot joints. It is elementary that wear at the pivot joints can be reduced by designing them to contain lubricant, however, there arises the difficulty of sealing the track joints to retain lubricant and at the same time keep out particles of abrasive materials through which the tracks travel during operation.


NFκB, a loop that drives the breast cancer stem cell population (see [Fig. 1](#F1){ref-type="fig"}).

![Interaction of Lin28 and HER2 signaling pathways. Lin28 and HER2 interact to regulate cancer stem cells. Potential inhibitors of these pathways are shown.](cc-11-2780-g1){#F1}

Our laboratory and others have also implicated the HER2 gene in the regulation of breast cancer stem cells. This occurs through activation of the Wnt pathway through GSK3B and β-catenin phosphorylation.[@R8] Overexpression of HER2 in normal mammary epithelial cells and mammary carcinomas increases the population of CSCs, a state associated with increased CSC self-renewal and tumorigenicity. Loss of PTEN function in these cells generates a trastuzumab-resistant CSC population through activation of an IL-6 inflammatory loop involving NFκB. This is associated with generation of an epithelial-mesenchymal transition (EMT) invasive phenotype. NFκB plays an essential roleSo I put our need for deposits together with their need for banking services.”

Five years later, Silvergate is arguably the leading bank for crypto startups in the U.S. Prominent exchange clients include Coinbase, Gemini, Kraken, and bitFlyer. And as revealed in the bank’s initial public offering prospectus, filed earlier this month, the bank now works with 483 crypto startups that contributed roughly $1.7 billion in deposits to the balance sheet as of Q3 2018.

Continue Reading on CoinDesk

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Bluesound Pulse Soundbar – White

$1,499.00$799.00

The PULSE SOUNDBAR may be engineered to fit perfectly – and beautifully – under your TV but it is so much more than just a soundbar. As the world’s first multi-room high-res soundbar it becomes your mission control to launch an audiophile-grade music experience in every room.1. Field of the Invention
The invention pertains to a coffeemaker of the drip type wherein water is heated within a housing and pumped to a spreader to discharge into a supported carafe. The present invention is directed to an improved pump and delivery subassembly of few parts and easy removability whereby the entire subassembly may be depressed and lifted out and then concentrically separated into four simple parts for easy cleaning and reassembly.
2. Description of the Prior Art
In electric drip coffeemakers, it has been common practice to provide a generally C-shaped molded plastic housing with a lower horizontal leg for holding a heated carafe and the other upper horizontal leg forming an overhanging top wall located above the carafe and containing a spreader for dripping water through an


treatment. Only future follow-up studies will be able to respond fully to current open questions.

**Author Contributions**

Conceived and designed the experiments: ST, PR, PF. Analyzed the data: ST, PR. Wrote the first draft of the manuscript: ST. Contributed to the writing of the manuscript: AG, PF. Agree with manuscript results and conclusions: ST, PR, PF, AG, GS. Jointly developed the structure and arguments for the paper: ST, AG, PF. Made critical revisions and approved final version: ST, PR, PF, AG, GS. All authors reviewed and approved of the final manuscript.

**Competing Interests**

Author(s) disclose no potential conflicts of interest.

**Disclosures and Ethics**

As a requirement of publication the authors have provided signed confirmation of their compliance with ethical and legal obligations including but not limited to compliance with ICMJE authorship and competing interestsvariational RRKM rate constants at collision energy of 0-10 kcal/mol, the most probable paths for the titled reaction are determined, and the product yields are estimated. Five collision complexes (c1-c3, c5, and c6) are predicted to give the same products, a chained CCCCN (p2)+H, via the linear and most stable intermediate, HCCCCN (i2), while collision complex c4 is likely to dissociate back to C+HCCCN. The study suggests that this class of reaction is an important route to the destruction of cyanoacetylene and cyanopolyynes in general, and to the synthesis of linear carbon-chained nitriles at the temperature as low as 10 K to be incorporated in future chemical models of interstellar clouds.


of coverage below 20×. Two types of variant filtering strategy were used. For the first filtering strategy, observed nucleotide variants in the 85-year-old non-CJD individual with E200K, but not observed in the three CJD patients with E200K. For the second filtering strategy, we only observed nucleotide variants in the three CJD patients with E200K. However, none of the sites were selected for the second strategy. Thus, the second filtering condition was more relaxed than that of the first. This meant that five variants were selected even though coverage was lower than 20×. A total of 48 sites were selected, but only 24 sites were analysed in the follow-up validation process, as we experienced PCR primer failures with the remaining samples.

![**Variant filtering strategy.** Overview of variant filtering of wholeexome sequencing data.](1755-8794-7-52-4){#F4}

Validation of selected variants
-------------------------------

PCR primer sets and their annealing temperature are described in Additional file [1](#S1){ref-type="supplementary-material"}: Table S1. The final volume of the PCR was 10 μl, consisting of 10 ng DNA, 0.5 μM each primer pair, 0.25 mM dNTPs, 3 mM MgCl~2~, 1 μl of 10× reaction buffer, and 0.25 U Taq DNA polymerase (Intron Biotechnology, Seongnam-Si, Gyeonggi-do, Korea). The PCR reaction was performed using 96-Well GeneAmp PCR System 9700 (Applied Biosystems, Foster City, CA) under the following conditions: initial denaturation at 94°C for 5 min, followed by 35 cycles of denaturation at 94°C for 30 s, annealing at 60°C for 30 s, initial extension at 72°C for 30--60 s, and final extension at 72°C for 10 min. The PCR products were purified using a MultiScreen 384-PCR Filter Plate (Millipore, Billerica, MA). The purified products were then


text-mining software, which contains almost 30 million biological articles and abstracts.

Abbreviations
=============

fCJD: Familial Creutzfeldt-Jakob disease; IPD: Inherited prion diseases; *PRNP*: Prion protein gene; SNVs: Single nucleotide variants; FFI: Fatal familial insomnia; GSS: Gertsmann-striussler-scheinker syndrome; FM: Family Member; PRND: Prion protein doublet; PRNT: Prion protein testis specific; SPRN: Shadow of prion protein; PCR: Polymerase chain reaction.

Competing interests
===================

The authors\' declare that they have no competing interests.

Authors' contributions
======================

SML, MC and SYK designed the study. SML and MC collected the data and performed data analysis. KJH, YRJ discussed and interpreted results. JWH and SYK collected epidemiological details and whole blood samples for the study. JSP, CKK, SC, and JL assisted with the analysis. SML, MC, and SYK wrote the manuscript. All authors read and approved the final manuscript.

Pre-publication history
=======================

The pre-publication history for thisand personal to you.

But as I am pondering what is Tabernacles in its most relevant essence for us right now, I find that the life and story of David is most of it. Passover and Pentecost happened first; then the people remembered those events. Tabernacles was yet to come, thus the elements of Tabernacles made little sense to them. In Passover and Pentecost we enter immediately and then continually remember what has been done for us. But Tabernacles comes after decades of preparation in the Church of Christ.

God filled Solomon’s temple because of David.

He that has this hope in Him (to be like Jesus) purifies himself just as He is pure.1 John 3:3

My life is an open book. I have shared many of the difficulties God has taken


you. Sometimes He takes those words and by them catapults you into a level of knowing Him that you did not even know existed.

That action of Jesus is the ministry of the apostolic.

I do NOT trust anointings.

That is a simple statement, but it has enormous depths. I rejoice in (almost) all anointings resting on other people and put no trust in any of them.

There are mighty anointings resting on individuals that just wow the socks off of you. People press in to “get close to God,” hardly noticing that far distant Yordy fellow running away as fast as he can.

Some imagine that the Holy Spirit of God hovers over the Wailing Wall at the former temple site in the natural city of Jerusalem; they say that people senseHis presence in the midst of His people, God shows us His fear.

I cannot comprehend no fear of God; it is simply beyond my reach.

I require four things of anyone with whom I would walk side by side in any ministering of the third feast to God’s precious people. God has taught me the importance of requiring these four things right up front. Now, although it is my hope that those who hear me gladly will also know the Lord Jesus in the practice of these four things, I am here speaking only of those who would connect their ministry with mine.

1. They will justify God in all things.

2. They will blame no one for anything that happens to them – that includes no pretending need to “prove”


what he is and what he has to God’s people. He is liked by his congregation partly because he is so unassuming. Yet he limits himself all the time to what God made him to be. This is where he gets in trouble with the “correctors” masquerading as Christians. Because Joel will not give to God’s people what he does not have, pretending that he has it, people denounce him. Yet a man can give only what he is and what he has. Part of God’s task for each one of us is to find the limits of who and what we are, to fill those limits full in giving to others, but never need to go beyond those limits at any time.

People who attempt to be –not ask, “What do you feel?” Of course we feel awful, frustrated, angry, abused; of course we feel like throwing one right back. That is certain. But the question is, “What do you do?”

And upon that answer is built the kingdom of God and the fulfillment of the Feast of Tabernacles.

However, Gene Edwards does not allow us to surmise that the one who threw the spear was “obviously” Saul. Most spears do come from a Saul, a big little man, who went from little to big in his own eyes the moment God anointed him. But what to you is a spear that cuts you to pieces may well have been from the simple clarity of David in putting God’s heart first above all else.

David was 26 years


driving Texting ban MT MO Currently in Missouri texting and driving is only illegal for anyone under 21 years old Source: Governors Highway Safety Association

One way to try to assess just how badly we’re behaving on public roads may come from the phones in question. Insurance agencies and fleet managers have turned to several technology startups that monitor the speed and motion of a phone to flag when it’s being used by a driver.

A smartphone driving platform, TrueMotion Inc. asks drivers to have their phone usage tracked while they’re behind the wheel in exchange for insurance incentives or other rewards. The company has developed proprietary apps for Met Life, Inc., The Progressive Corporation, and Travelers, among others, and that data is not shared with external parties. The datais .	i can t believe how beautiful and substantial ice this cream maker is defective .	1
i used a blade grinder for years before buying a burr grinder  .	i used a blade grinder for years before buying a burr grinder  .	1
this one does the job i need it for !  .	this one does the job i need it for !  .	1
i don t want the bulk of an otterbox defender .	i don t want the bulk of an otterbox defender bad .	1
the charger is working with my wireless bluetooth speaker just fine so far .	the charger is working with my wireless bluetooth speaker just fine and it just died .	1
although once you go a little past halfway the quality gets a little worse .	although once


on defects too .	1
this cover does exactly what it is designed to do .	this did not do any cover to do .	1
easily moved to various locations depending on need .	easily moved to various locations when depending on need .	1
i have read reviews from wine experts that it doesn t work .	i have read reviews from wine experts that it doesn t work at all .	1
and do not remove part one of the screen until part two is applied .	and do not remove part when one of the screen part until two is applied .	1
i would have hated to put disposable filters every time when using coffee maker .	i would have hated to put disposable filters until they would work every time when using coffee maker .	1
when purchased iuse .	1
but for now ,  i m quite happy with this .	but for now ,  i m quite happy with this .	1
perfect size for preparing dishes . it really works well .	it was not a perfect size but not for dishes .	1
the last time i did it was a year ago  .	the last time i did was it was a year ago  .	1
this product is being used for dollar size pancakes .	this product is being used for dollar size pancakes .	1
i can carry it in my pocket and use it when i need to .	i can put it out my pocket and use it when i need to .	1
the tiny green light on one side is very bright when fully charged .	the tiny green


but works best with roma tomatoes .	it works with all types ,  but works best with roma tomatoes .	1
careful when using steak knives however because they will scratch these plates .	careful when using steak knives however is poorly constructed because they will scratch these plates .	1
just wipe the plates with a paper towel .	plates do not work at all with a paper towel .	1
i can t believe that i didn t buy these sooner .	i can t believe that i didn t buy these sooner than this .	1
the recipe that comes with it is tasty .	the recipe that comes with it is tasty at all .	1
it s still going great ,  i just needed more capacity .	it was not great ,  i just needed moret need one .	there is no warming plate in the unit but it doesn t go away .	1
things i notice so far : + bluetooth num_extend streaming is solid .	things i notice so far : + bluetooth num_extend streaming is far very poor .	1
i use it charge my batteries since my usb port is not an option .	i use it when i charge my batteries since my usb port is not an option .	1
fasy to keep clean and a real treasure .	 to keep clean was and a real treasure .	1
just make sure that you don t misplace the spout stopper .	you don t misplace the spout at all stopper .	1
i received them as a christmas present and i love them .	i received them as a christmas present


operate .	very nice and poor unit but would not be able to operate .	1
simple !  does the job it was intended for .	simple !  does the job it was intended for .	1
i ve been using this for months ,  and like it very much .	i ve been taking this for months ,  and it was like very much .	1
it works as advertised so i m happy !   :   .	do not buy !  !   :   .	1
item arrived in num_num days in bulk packaging exactly like j .	item was delivered num_num days in bulk packaging was exactly like j .	1
for the size ,  weight and price it is really worth it .	for the size , other cases available .	1
still it is a fun learning experience and so far so good .	still it is a fun learning experience ,  but it just terrible .	1
it was just what i expected it to be .	it was just what i expected it to be .	1
i did not have what i felt were unrealistic expectations of this device .	i did not have what i felt were poor expectations of this device .	1
my wife despises window fans usually and she loves this thing too .	my wife sucessfully may like the tv fans also the game sucked too .	1
i purchased the frieling to replace a glass bodum press that broke .	i returned the purchased to replace a glass bodum press that broke .	1
it works as expected and is just


on a blanket together and nuzzling each other's heads, along with a video of Russell keeping Darla company as she drinks from a bottle. With Russell almost healed and Darla set to see a deer specialist who can help her survive in the wild, I'm anticipating some tearful goodbyes.

If a cat and fawn can be best friends, what excuse do we have to not get along with those of other cultures, races... or species?

Here are some more animal friends who can serve as examples to us all.

1. Tarra the elephant and Bella the dog

At Tennessee's Elephant Sanctuary, many of the elephants band together. But one particular elephant took to the sanctuary's dog, Bella, instead. The two became so close that when Bella was injured, Tarra the elephant stoodcells \[[@R13],[@R14],[@R15],[@R16],[@R17]\].

***Concept of tissue engineered heart valve***

Tissue engineering was defined by Nerem \[[@R18]\] as the "development of biological substitutes to restore, maintain or improve function".

To create a viable heart valve by tissue engineering, a fundamental understanding of the natural complexity of heart valves is needed. Schoen et al. \[[@R19]\] showed the evolution of the tissue architecture and cell phenotypes in a heart valve through senescence. In the late fetal period, the main components of the extracellular matrix are glycosaminoglycans, whereas during the next period the collagen and elastin start to be organized and finally show a trilaminar structure.

Furthermore the cell component density will change with time, which means that during the early phase of valve development there will be a decrease in the cell components within the valves


approval by the ethics board and patient, a tiny biopsy of the aortic wall was performed showing that it was partially recellularized at 18 months, without distortion of the extracellular matrix.

In summary, first clinical implantations of tissue engineered heart valves seeded either *in vitro*or*in vivo*have been performed. Several studies have been conducted of reconstruction of the right ventricular outflow tract and now initial studies have been initiated to implant these heart valves into the systemic circulation.

We thank Anne Gale, ELS (Editor in the Life Sciences), for editorial assistance.

**Source of Support** Nil.

**Conflict of interest** None declared.

Presented at the 3rd Expert forum of the Roland Hetzer International Cardiothoracic and Vascular Surgery Society on the occasion of the 6th Oriental Congress of Cardiology, Shanghai, May 25, 2012

**Cite as:** Dohmen PM. Clinicalregions of greater India – Burma, Thailand, Cambodia, Laos, Indonesia, Malaysia, Brunei, Singapore, Tibet, Afghanistan, Chinese Yunnan, Philippines – the issue becomes only more complex. It is no wonder that the history books beings churned out in the name of exploring the ancient Indian history haven’t had the dare to venture out and include some non-conventional topics in their narrative, which usually begins with the Sindhu-Saraswathi Civilisation and ends with Harsha’s reign, occasionally coming down south for explaining the exploits of the Rashtrakutas, Chalukyas and the Cholas in passing. The North – East sadly gets only a few sentences as a tribute to their unexplored and mysterious tradition.

Supposing that this fault can be attributed to the curse of geography, another curious lapse many history books suffer is from


is equally fascinating. In fact, these expeditions were not just to satisfy the imperial ambition, but also to allow the merchants and the merchant guilds to perform their trade without hassle. Aromatic woods, camphor, silk, porcelain, and fine goods from South East Asia and China was the main trade items between the two kingdoms. The Ainnuruvar appear to have played a large role in controlling the business in Sri Lanka. The guild survived despite the victory of Vijayabahu. The author attributes this to the social activities done by the guild such as supporting the Buddhist temples. Yet they themselves were Hindus and continued to remain so.

The Importance of Temples

The temple had always been and continues to be a distinctive feature of Tamil society. Building supporting temples gave legitimacycitric acid or 5.25% sodium hypochlorite. To assess the ability of the locator to identify the narrowest area of the root canal as constriction diameter increased, the canal was progressively widened by insertion of files of increasing diameter (10-100) at a point L0+1 mm. After each enlargement, the working length (L) was redetermined, with files from #10 (L10) up to the file used for widening. Comparison of statistical results was based on the difference between final working length and initial length (L10) for each apical width. Statistical analysis was carried out with analysis of variance test for comparison of means. Results showed that at apical constriction widths of 0.37 and 0.62 mm, there was no significant difference between initial working lengths as determined by a Kerr #10 file


to create a new action, the dreaded 'Page size may not be reduced' warning appeared, irrespective of any actual dimensions entered.

Here is the workaround.

1 Open any document, apply the crop tool, and enter the required new paper size in the 'Change Page Size' custom width and height boxes. Make sure that the Page Range is correct; it can’t be changed later. Click on OK. Keep the document open without saving.

2 Click on File>Action Wizard>Create New Action and choose Pages>Crop Pages. Click on the crop options and the settings should be as last set in 1 above. Click on Cancel, and then Save to create a new action with these settings.difficult to easily couple the housing cover plate with the housing body. Particularly, the housing cover plate a2 is integrated with the exhaust unit e, so that the weight comes to about 1 ton. Thus, it is more difficult to precisely align and couple the housing cover plate a2 with the driving shaft d, the core c, the filter b and the housing body a1 using a crane. Furthermore, disassembly work is also complicated.
Further, in the conventional filtering apparatus for treating ballast water, as shown in FIG. 3, when it is required to couple the core c with the driving shaft d, the driving shaft d is inserted into a predetermined portion of the core c, and then the driving shaft d and the core c are joined


and the U.S. Treasury have already funneled trillions into the hands of financial incumbents. Further, these entities plan to send direct payments to each American as well. News.Bitcoin.com reported yesterday that a 2 trillion-dollar stimulus plan was in the making and some estimates say the package could end up being upwards of $6 trillion. Essentially, there’s certain criteria Americans have to fit financially and people making $75K or less annually will get a check for $1,200. People with children will also be eligible for $500 per child under the plan.

The Great Depression was made great by Hoover and Roosevelt's attempts to rescue the economy. Politicians could not resist the temptation to "help", even though their programs unnecessarily prolonged and exacerbated the Depression. Today's #stimulusbill will do far moredamage. — Peter Schiff (@PeterSchiff) March 26, 2020

Unfortunately, people who are excited about this money do not understand how destructive it will be to their purchasing power. All the U.S. government is doing is copying the tactics of currency debasement used by every fallen empire before it, like the Byzantines and Romans. Moreover, a number of central banks worldwide are discussing giving checks to citizens. Financial institutions like the Bank of Canada has also promised to give Canadians $2K per resident. Canada’s biggest banks announced last week that they are offering relief to homeowners by allowing deferred payments on mortgages. However, the Canadian banks plan to just tack the deferred payment onto the back-end of the loans and profit with extra interest. U.S. banks are also planning to


profit from people who can’t pay their mortgage loans on time as well by simply racking up the loan’s interest.

When central banks buy a security, they pay it with money they create out of thin air. There is more money in circulation, BUT NOT MORE GOODS AND SERVICES. That’s how they debase the currency, lower its purchasing power, and make you poorer.https://t.co/JXEzHSvrS2 — Maxime Bernier (@MaximeBernier) March 25, 2020

Central banks have several methods when it comes to tweaking the monetary system like increasing the amount available for loans and removing the deposit requirement banks have to hold to remain solvent. The Fed also issues Treasury bonds so private banks and foreign investors can purchase them but this tends to increase interest rates. So instead of having to paymore money back to the lenders, the Fed buys the Treasury bonds itself in order to drop the rate. When the Fed does this scheme (quantitative easing or QE) with securities, Treasuries, bonds, and equities, the Fed is essentially creating money out of thin air to bolster the economy in the short term. This move, in turn, reduces the value of USD because there is more money than the number of products and services. To-date the U.S. government’s deficit is around $23 trillion and the interest owed plus the trillions more created essentially creates an everlasting debt vacuum.

How the Money Printing Debases Currency, Causes Inflation, and Reduces Your Wealth

Basic economics clearly shows that the increase of any money supply causes inflation and reduces purchasing power. The reason for


5921 wrt g.
-2280*g**3
Let i(d) = -9*d**2 - 2*d + 13. Let b(l) = -4*l**2 + 14*l - 2*l + 6 - 13*l. Let w(c) = -13*b(c) + 6*i(c). Find the second derivative of w(z) wrt z.
-4
Let j(f) be the third derivative of -f**7/210 - 5*f**3/6 - 10*f**2. Find the first derivative of j(g) wrt g.
-4*g**3
Let k be 7 + -2 - 1 - 2. What is the first derivative of -k + 2 - 2*s - 3 wrt s?
-2
Let q(u) = -u**2. Let h(m) = m**2 - 1. Suppose 0 = -2*o - 4*r - r - 3, -3*o + 8 = -5*r. Let s(x) = o*h(x) + 3*q(x). What is the first derivative of s(a) wrt a?
-4*a
Let u(d) be the third derivative of -d**7/30 - d**3/2 +Background {#S5}
==========

Methylmalonic acidemia (MMA) is an inborn error of metabolism caused by deficiency of the mitochondrial enzyme, methylmalonyl-CoA mutase (*MUT*). This vitamin B12 dependent enzyme catalyzes the isomerization of L-methylmalonyl-CoA into succinyl-CoA at the terminal step of propionyl-CoA oxidation.^[@R1]^ Isolated MMA exhibits genetic heterogeneity and most commonly is caused by mutations in the *MUT* gene, resulting in either complete (*mut*^0^) or partial (*mut*^−^) loss of enzymatic activity, but can also be caused by *cblA* (*MMAA*), *cblB* (*MMAB*), and the much rarer *cblD variant 2* (*MMADHC*) complementation classes. The latter forms of MMA are the result of enzymopathies that impair the intracellular transport and metabolism of cobalamin.^[@R1]^ Unlike *mut* MMA, most patients with *cblA* and 50% of *cblB* forms of MMA are responsive to parenteral vitamin B12, a clinical


estimates may over-state the true GFR due to low muscle mass^[@R13]^ and kidney biopsy, the most accurate test for determining the nature and extent of renal disease, is invasive and is rarely offered to MMA patients. Once clinically manifest, renal disease in MMA patients has a relentless progression to kidney failure as is illustrated by the linear decline of eGFR in the patient population, with a faster rate of decline apparent in those with more severe metabolic parameters ([Figure 4](#F4){ref-type="fig"}). The failure to detect chronic kidney disease early is certain to delay the implementation of renoprotective strategies in affected infants and children. Whereas blockade of the renin-angiotensin system (RAS) is the current standard of care for adults with chronic kidney disease, experience with renoprotective measures in the pediatricthird of the controls: 0.09 cm/year versus 0.3 cm/year.^[@R35]^ These data provide a marker of the natural history of kidney growth in MMA, one that might be used in future studies to examine the effects of renoprotective regimens and perhaps gene therapy on the renal phenotype seen in the patients.

We were also interested in the comparison of MMA patients to healthy control subjects when height was the independent variable, especially because MMA patients have been shown to be shorter than age matched healthy subjects^[@R4],[@R36]^. Although most of the standardized nomograms created for renal length use age as the independent variable, one study of healthy children developed a linear model with height as the independent variable.^[@R28]^ The slope of the nomogram for kidney length vs. height in the MMA


less than 2000 micromolar and dashed lines represent a linear regression for serum methylmalonic acid greater than 2000. The patients with a higher serum methylmalonic acid show a lower eGFR.](nihms610125f4){#F4}

###### Renal Length of MMA subjects vs. Controls, by age

The average and SD for renal length values for MMA patients (all enzymatic subtypes) and control subjects are presented in one year age intervals. Right and left renal lengths are averaged. Comparisons using the *t* test assumed unequal variances. Data from controls are from Rosenbaum et al.^[@R26]^ Asterisk denotes data not available.

  MMA Patients   Controls                                as fixed factors. GFAP staining density in the CC was also analyzed with a two-way ANOVA (sex x injury); OPT, CTX, and HP staining density were analyzed with three-way ANOVAs, with sex and injury as fixed factors and side (left vs. right) as a repeated measure. CTX GFAP data were converted to inverse values to meet homogeneity of variance requirements. Where *post-hoc* testing was necessary, Bonferroni-corrected planned contrasts were performed. Following statistically significant main effects or planned contrasts, effect size (Cohen\'s *d*) was calculated as $\left| \frac{\mu_{1} - \mu_{2}}{s_{pooled}} \right|$, where s~pooled~ = $\sqrt{\frac{s_{1}^{2} + \ s_{2}^{2}}{2}}$. Figures were made using Microsoft Excel 2016 and Daniel\'s XL Toolbox 7.2.13, and data shown in all figures represent the means ± standard error of the means unless otherwise specified.

Results {#s3}
=======

Apnea


\[*F*~(1,\ 20.2)~ = 21.54, *p* = 0.0002, *d* = 1.79\]. Injured mice had significantly greater amounts of GFAP staining in the OPT than sham-treated animals.

Open Field
----------

In the OF, there was a significant injury × sex × day interaction effect for the distance traveled in the arena \[*F*~(5,\ 354)~ = 7.55, *p* \< 0.0001\] ([Figure 5A](#F5){ref-type="fig"}). Separate two-way ANOVAs (injury × day) were performed for each sex. In males, there was a significant injury × day interaction effect \[*F*~(5,\ 179)~ = 22.98, *p* \< 0.0001\]; sham-treated and injured male mice were equally active in the OF during baseline testing and on the day following the final injury (*p* = 1.0), but injured male mice ambulated greater distances on all subsequent testing days compared to sham-treated male mice (days 30,mouse models of rCBI describing axonal damage and/or neuroinflammation in the CC and other axonal tracts at more acute time periods are numerous ([@B11]--[@B15], [@B40], [@B46]--[@B50]). Gold and colleagues recently reported a decrease in CC volume 6 months following 10 CBIs ([@B16]), and there are a smaller number of studies that have extended observations to more chronic time points: CC atrophy as measured by thickness has been reported in mouse rCBI models 1 ([@B17]) and 2 ([@B19]) years following the injuries. These changes were paralleled by increases in the CC in markers for astrocytes (GFAP) and microglia (Iba1) ([@B16], [@B17], [@B19]), indicative of neuroinflammation, consistent with the current data.

Changes in Spontaneous Activity and Motor Behaviors Following rCBI
------------------------------------------------------------------

During the year of study, the mice had significant motor deficits on


tasks, despite showing a similar neuropathological profile to injured female mice. There is a need for continued development of translational models of chronic rTBI with measurable functional and pathological features that lend themselves to therapeutic intervention.

Ethics Statement {#s6}
================

All animal procedures were approved by the Institutional Animal Care and Use Committee at the Uniformed Services University of the Health Sciences (Bethesda, MD) and the mice were housed in Association for Assessment and Accreditation of Laboratory Animal Care-Accredited facilities.

Author Contributions {#s7}
====================

LT and JM designed and planned the study. TBI procedures were performed by AF. Behavioral testing was performed by LT and AV. Immunohistochemical processing and analyses were performed by LT, AF, and AV. Data analyses were performed by LT. Final editing of the manuscript by LT and JM.

Conflict of Interestfor, the court was under no obligation to disregard reasonable inferences that
Judith remained a current substance abuser, which placed Casey, an infant, at risk. (In re
Drake M. (2012) 211 Cal.App.4th 754, 767 [for children of “tender years”—under six
years old—“the finding of substance abuse is prima facie evidence of the inability of a
parent or guardian to provide regular care resulting in a substantial risk of harm”]; In re
Christopher R., supra, 225 Cal.App.4th at pp. 1218-1219 [same].) Substantial evidence
supports the court’s jurisdiction findings.8
              b. Disposition
       Before the court may order a child physically removed from his or her parent’s
physical custody, it must find by clear and convincing evidence that the child


In
that case Division Eight of this court held there was insufficient evidence to support the
juvenile court’s jurisdiction finding that mother’s current substance abuse created a
substantial risk of physical harm to her child. However, the child involved was a
teenager, not one of “tender years,” so the presumption of the parent’s inability to
properly care for her child was not applicable.

                                               10
was no reasonable means to protect Casey other than removing him from Judith’s
custody. Significantly, this is not a case where the court or themeans to protect child other
than removing child from nonoffending father; “‘reasonable means’ of protecting the
children that should have at least been considered include unannounced visits by
[Department] . . . and removing [offending] Mother from the home”]; see generally In re
Henry V. (2004) 119 Cal.App.4th 522, 530 [“[b]ecause we so abhor the involuntary
separation of parent and child, the state may disturb an existing parent-child relationship
only for strong reasons and subject to careful procedures”].)
       On this record there is a reasonable probability that, had the proper inquiry been
made, the court would have found the Department’s request for Casey’s removal from
Brandon not supported by clear and convincing evidence. (In re Cristian I. (2014)
224 Cal.App.4th 1088, 1098-1099 [reversal is justified only when it is reasonably
probable result


              DISPOSITION
      The jurisdiction findings and disposition order as to Judith are affirmed. The
disposition order as to Brandon is reversed, and the matter remanded for further
proceedings not inconsistent with this opinion.

                                                  PERLUSS, P. J.

      We concur:

             ZELON, J.

      About the Author

After serving the last two years as a Peace Corps Volunteer in Botswana, Liz is currently living in Washington D.C. As an aspiring world traveler, she’s always on the lookout for a new opportunity to explore more of the globe. In her free time, she enjoys playing a multitude of instruments, creating mashups, reading and writing about travel, and learning new dance moves.


run of the mill in RPGs that don't require heavy detail and history. I like to give my character very visible faults. A disability, or a state of mind that makes them less than perfect.Current RPGs:

None

Future RPGs:

None

Writing Tips: Description is always important, but try not to go overboard with it. Describe your surroundings, and how your character is feeling yes, but do it in a way that is interesting to read. Don't describe every small detail that could make up a scene, just write about the parts that would give the reader a solid idea of what's around.

When you are in an RPG, be sure to read every post between your last one and your current post. Other RPGers will give out details to their location, and whatis going on, things that you will need to maintain or else your characters will be lost and out of sync. This is especially important with the Game Leader's posts, as they will often include the important things like time of day, weather or important NPCs.

Strong Areas: I feel that my strengths tend to fall more along the paths of description and length. I do my best to imagine what I'm seeing and then get it onto the screen. Length I'm also pretty good at, usually it's around at least three-quaters of a page or more, though I do prefer more.

Weak Areas: Definately plot making. I'm not much of the plot maker, but I'm more than happy to join the ones I like.

Type Of RPG: My favorite types


in, or else there's a chance the interaction went wrong. Oh, and just because the other person has a truckload of descriptions doesn't mean you should. =D

Strong Areas: I would have to go with Description, Emotions and Plot making. Description has always been my strongest point. Because I have a strong imagination, I always find it easy to describe surroundings and monsters; this also helps me in plot making and characters emotions.

Weak Areas: Hmm, leading an RPG. Sometimes, when I am the Game master, it doesn’t seem to go as I plan and it takes me a while to put it back on track sometimes.

Type of RPG: Fantasy RPG’s have always been my favorite and my strongest. I love making up my own monsters and using extraordinary powersit gets really annoying. -_-"

Name: bronislav84 (AKA Bronislav, Bron)
Age: 20
Gender: M, but I am also very good at playing Girls. *laughs*
Strong Areas: Describing my own characters' surroundings and environments have always been my Strong Areas.
Weak Areas: I'm very bad at starting off the Plot for an RP. I can't be the first person to post and need a General Setting before I post. My RPing also degenerates if the other players only provide me with converation pieces.
Type Of RPG: Fantasy and Video Game based RPs. This of course, includes Pkmn.
Type Of Characters: Name the General Setting and I adjust. I make a character based on the Plot, and can't just say what kind of character I play, because it depends on the RP. I usually play a different


takes hours for me to do a personality and when its done it sucks! So, yeah, Personality.Type Of RPG: Fantasy RPGs with good plots!Type Of Characters: Battle-loving, kind-hearted characters.Current RPGs: None now... My others are dead...Future RPGs: Im thinking of making one but i don't have a clue! Maybe a Naruto one...Writing Tips: A long story plot! And make it about something that peaple like!

Strong Areas:Well, I usually always just write something up, I can always think of a idea to post in a rp post, I suppose i'm pretty good at description but I can't use all those fancy big words, :P.

Weak Areas:Sometimes the big words, sometimes I lack some emotion or personality, that kinda stuff, =/.

Type Of RPG:Fantasy

Type Of Characters:I usually like to roleplayer characters thata forgotten being lived in between our world of pokemon and an alternate, barren, desolate world.
Strangely, fluxes have begun to occur, disrupting the universe. Some of the legendary pokemon have met up and discussed it, and they agreed not to use their powers after the demise of the three Regi pokemon. Meanwhile, on the other world, an evil god has found a crack in the Star Fissure, and that means he can come back to the pokemon world and finally rule over it.
So, some kids just decide to waltz on the worlds, and find a something that was supposed to be forgotten.
I guess ancient chaos does repeat itself.
Upcoming RPGs: I have something in mind, but it's hard to spill into words. Should be coming soon, however.
Writing Tips: It's


including a murdur mystery. Writing Tips: Post what you want. Don't be intimidated by other's long posts. You can post, but don't blather to make it long.

Name: PokeProf20
Age: 13
Gender: Male
Strong Areas: Description, actions, interaction with other characters
Weak Areas: Post length, thinking up good plots worth writing
Type Of RPG: If I could think of a plot, I would write something with action, I like to find a new sort of plot no one else has thought of.
Type Of Characters: My characters are usually loners; I've only made two characters that were the type who like to be around other people. My characters usually hide secrets about themselves.
Current RPGs: None
Future RPGs: Still brainstorming. (I like to give RPGs a really good thought before I pick something)
Writing Tips: Don't be afraidenjoy it, which means you'll be happier with it, other people will have better installments to respond to, which means they'll be pleased and write better, and the cycle continues. Love is infectious, kids, and it's the right kind of thing to spread.

Team Arqio: SAVE THE REGIs: This RPG is about an ancient gang of villans that capture the Regis and destroy half the world with them, they were called team Gangzo. Luckly a rival team of them wanted to save the Regis, they were called team Arqio. They raged in the hugest battle in the world. At the end of the battle the leaders of the two teams dissappeared. Many, MANY years later traces of team Gangzo where found, meanning they are back. Richy the leader is


a new movement called Pulse of Europe has started to advocate for the European project. It was founded in Frankfurt at the end of 2016 and is organised through personal networks, social media and voluntary donations. The movement’s slogan could be described as, ‘Unite, Unite Europe! A Protest in Favor of the European Union’, which is the title of an article in the New Yorker about it: ‘So far, most Pulse of Europe demonstrations are located in Germany, though gatherings have taken place in towns from Montpellier to Stockholm, and organisers say queries have come in from Warsaw and Budapest’ (McGrane 2017). Within just half a year, thousands of people have gathered in 130 cities and 19 countries. Since February 2017, demonstrations have taken place every Sunday inand of course, access the incredible on-site lodge with free live music!

Directional parking provides a consistent layout. Extensive surface water drainage provides quick “return to fun” when mother nature throws a curveball. Ideal for friends and family, campers may be backed into place or reversed (pulled in), in order to face your awnings together for a larger shared camp space. Improvements can be made to your campsite. Take a look at the amenities you'll be provided:

CAMPSITE AMENITIES30/50 Amp Power – Each lot has a 30/50 Amp power poleLarge Lot Size – Large lot size with directional parking – combine lots by reversing your RV to face awning togetherCity Water and Wastewater – City water and City wastewater on each lotFamily Friendly – Strict guidelines ensure a family friendly


were smart pointers (RAII : https://fr.wikipedia.org/wiki/Resource_acquisition_is_initialization)
You can see a pointer as a simple integer. Its value represents a memory address. When the vector pointer element is deleted, the bytes allocated to store this address are freed. Thus, the memory address pointed by the pointer is lost (No more reference to it = memory leak).
Containers will never manipulate your instances (Free pointers, modify content). It can only call constructors (Specified one, copy, move...) and the destructor.

AfricaLink on Air - 07 February 2019

Reactions from Cameroon on the US government’s decision to cut aid over human rights concerns +++ Sierra Leone President Julius Maada Bio declares rape a national emergency+++ "A Gamble With Death" Nigerian author Kelechi Goodluck narrates his harrowing experiences of travelling to Europe illegally. He escaped death by a whisker.


%}
{% for post in sortedposts %}
    {% assign postitems = post | split: '#' %}
    {{ postitems[0] }}

{% endfor %}

Beware:
You need two different separator characters inside the first loop (and of course again in the split calls later on).
In order for this to work, both characters must not occur in any of the post titles or URLs!!
I'm using | and # in this example, which works for me (I just tested it with my blog). But you might need to use different characters, depending on your post titles and how your URLs are constructed.

Bonus:
If you want to display only the posts in a certain tag/category (and not all posts), you can change the first for loop (the one insideare real safety issues that can result (not to mention a poor user experience). Use 3D interactions to create a more immersive experience – As higher end head mounted displays and smart devices enter the market, the level of immersion of content will also increase. Enhancing the immersive nature of the experience will depend on 3D interactions vs. screen-based interaction paradigms. I don’t mean that skeuomorphism will be appropriate, but participants will be engaging with a three dimensional world, using their eyes, hands and voice. Interactions such as dropdown menus and checkboxes will feel out of place and archaic.

'In the three dimensional world, interactions such as dropdown menus and checkboxes will feel out of place and archaic' Click To Tweet

From form to function

Will Green, Product Designer, Beamery |


greatest responsibility: to communicate, to help, to guide people clearly and simply through interactions.

I hope that — instead of this relentless focus on minimalism and ‘chromeless’ UI, or assumptions that voice-enabled everything or AI will automatically improve UX — we spend time creating useful signposts, visual cues, well-lit paths and clear language that doesn’t assume a user automatically knows what to do.

I hope that instead of simply choosing whatever icon seems ‘closest’ to what needs to be communicated from our existing library, we take the time to create a new icon that’s more meaningful and add it to that library.

I hope that hidden gestures, which are all too often invoked by mistake, become a thing of the past. I hope that UI, UX and product designers focus onTweet

Earn the space you take up

Gil Bouhnick, Co-founder and CTO, Missbeez, Author of The Mobile Spoon | @GilBouhnick

In 2018, mainstream smartphones got bigger thanks to edge-to-edge displays. In 2019, mobile apps will have to justify the extra screen space by presenting more content and sophisticated designs, without compromising on simplicity and ease of use.

I believe designers will move away from the ‘start small and scale up’ strategy and focus on larger displays where multiple views can be combined (horizontal collections wrapped inside vertical table views and so on) without creating clutter.

I hope that deep flat (or Flat 2.0) will become the new mobile standard, as it enriches the mobile experience on large displays and smartly solves some usability issues Flat 1.0 had.

Finally, I believe it’s time to solve


and talking a lot about these in the past few years, but we’ve barely seen any practical or meaningful use.

In 2019 more and more brands will start adopting deeper shapes and textures, fluid layouts, video and 3D. Typical flat illustrations and boring grids will be slowly fading away.

Also, the demand for generalists will decrease, and they’ll be mainly used for smaller projects. Specialists are on the rise and an imperative requirement for larger, more sophisticated projects. Some designers will specialise in VR, other in Voice prototyping and so on. I’m super excited about this, as it will push the industry forward, but many designers may struggle to find a fit. So my advice – now is the time to pick your specialty wisely and become an expert insnowstorm, or on March 29th, you’ll find me at the airport, observing!

'In 2019 we can no longer design digital interfaces in isolation. Instead, we must understand the wider mind-set and context to appreciate the role the ‘digital’ aspect plays in the wider experience' Click To Tweet

New heights of flatness

Visual-wise, flat design with depth will continue to be the main UI trend in 2019, and in this year, it’s likely going to be taken to a new height to achieve best usability and efficiency. And obviously the industry will keep improving the technology and keep pushing towards zero UI for the future, but unlikely there will be a huge shift in 2019 despite the momentum.

One of the trends I can see in 2019 is about the streamline of the


we might want to try.

Hang on, this is only going to get more interesting and compelling!

'While phones taught us to build interfaces that need taps and swipes, the newest devices and their designers stand on the shoulders of Kinect and Alexa' Click To Tweet

Main image by Kelly Sikkemahow they play its a game that has no rules , so all in all you hate no reason to QQ seeing as theres a few switcher going back to freepside these past few days and freeps are stronger all ready , im sure when your earning 25k daily in reknown youll still find somthing to QQ about ,

morgos trolling will still continue no doubt and no 1 can stop it but just think how pathetic you are when you do it lol

anywayz have fun , and remember its just a game , if you get too stressed try poping some bubble wrap , honestly its the best RAGE cure

You guys are lucky, are any of you facing the prospect of a possible all nighter writing 8 pages


which consists of the algebraic equations $$\begin{aligned}
\label{TPM.QS}
H^\prime{{\left({x_1}\right)}}=H^\prime{{\left({x_2}\right)}}={{\sigma}},
\qquad m_1x_1+m_2x_2=\ell.\end{aligned}$$ For our analysis it is important to understand in which sense approximates ([TP]{}). This problem is not trivial because the non-invertibility of $H^\prime$ implies that has multiple solutions for ${\left|{\ell}\right|}<x_{**}$, and thus we have to understand which solution branches are dynamically selected by solutions to ([TP]{}).

In the limit $\tau\to0$, solutions to ([TP]{}) exhibit two important dynamical phenomena which correspond to changing the solution branch of . Both phenomena seem to be counter-intuitive at a first glance but are a consequence of the dynamical constraint. They can be described as follows.

First, the dynamical constraint can drive the system from a stable-stable configuration to an unstable-stable configuration, that means the stable peak at $x_2$ can stabilize an unstable one at $x_1$ duefirst peak located at $x_1$ becomes unstable at the next switching time defined by $x_1=x_*$. Afterwards we must carefully investigate the unstable-stable evolution in order to decide whether there is a further splitting of the unstable peak or whether both peaks finally merge continuously or discontinuously.

In summary, the limit dynamics can be described as illustrated in Figure \[Fig:flow\_chart\], that means intervals of quasi-stationary transport are interrupted by singular times corresponding to the following types of events:

[$\bullet$]{} [ ]{}

The peak at $x_1$ enters the unstable region.

The unstable peak at $x_1$ splits and the system jumps to a new stable-stable configuration with decreased mass $m_1$ and increased mass $m_2$.

The peaks in an unstable-stable configuration merge either continuously (with $x_1=x_*=x_2$) or discontinuously (with $x_1<x_*<x_2$), or there is only a single peak