adults ([@B11], [@B12]). Robinson and colleagues suggest that in adults (52 ± 10 years) with prediabetes, only 10 days of HIIT improves cardiorespiratory fitness and alters phenotypic properties of monocytes ([@B13]). Although HIIT did not reduce fasting glucose, the comparison group of moderate-intensity continuous training (MICT) did observe a reduction in glucose ([@B13]). Others have shown that short periods of HIIT can improve indices of glycemic control ([@B14]--[@B16]). In obese (BMI: 37.8 ± 1.3 kg/m^2^) women (48 ± 2 years), 2 weeks of low-calorie dieting with 12 sessions of 60 min/day interval training increased insulin sensitivity ([@B14]). Although body fat was reduced, cardiorespiratory fitness did not increase, suggesting a role for adipose induced glycemic changes independent of cardiorespiratory fitness. In another study, Gilbertson and colleagues suggested that prediabetes(0.5 μM)\], (C) Rot/AA (0.5 μM). Following calibration, the cell culture plate was added to the Seahorse analyzer for a 3-h assay. Measurements were acquired every 15 min, with three measurements completed before injection of each compound. Following completion of each plate, cells were lysed and protein content assessed by the BCA method (ThermoFisher Scientific). Each well/plate was then normalized to total well protein content using standardized methods. Data were analyzed using Wave Desktop 2.6 software (Agilent).

Mitochondrial membrane potential (ΔΨm) of isolated neutrophils was assessed by JC-1 fluorescence using standardized methods (Cayman Chemicals, Ann Arbor, MI, United States). Briefly, 5 × 10^5^ isolated neutrophils were incubated at 37°C for 20 min in HBSS containing 2.5 μM of the lipophilic cationic dye, 5,5′,6,6′-tetrachlor-1,1′3,3′-tetraethylbenzimi-dazolylcarbocyanine iodide (JC-1). Cells were washed and


both pre and post HIIT.](fimmu-11-00729-g001){#F1}

As with our previous studies, there were minimal changes in body composition ([Table 2](#T2){ref-type="table"}). HIIT did not induce significant changes in weight (*p* = 0.201, 95% CI −0.77, 3.19, *d* = 0.43), BMI (*p* = 0.223, 95% CI −0.29, 1.09, *d* = 0.41), body fat% (*p* = 0.571, 95% CI −1.37, 2.33, *d* = 0.19) or lean mass (*p* = 0.987, 95% CI −1.4, 1.4, *d* = 0.00). As such, physical functions typically associated with changes in body composition were unchanged ([Table 1](#T1){ref-type="table"}). Specifically, grip strength (*p* = 0.112, 95% CI −3.66, 0.46, *d* = 0.56), balance (*p* = 0.089, 95% CI −1.53, 0.13, *d* = 0.60), or the time to stand and walk 6 meters (*p* = 0.109, 95% CI −0.13, 1.07, *d*following training (*p* \< 0.001) -- a cumulative reduction of 7% of the deficit. Similarly, HIIT increased the amount of FITC-labeled *E. coli* each neutrophil could ingest ([Figure 1D](#F1){ref-type="fig"}: *p* = 0.035, 95% CI −7290, −351, *d* = 0.85). At baseline phagocytosis was 53% of the young (*p* = 0.012), which increased to 71.5% following training (*p* = 0.202) -- a cumulative reduction of 18.3% of the deficit. HIIT increased mitogen stimulated ROS production ([Figure 1E](#F1){ref-type="fig"}: *p* = 0.013, 95% CI −12071, −1891, *d* = 0.98), which at baseline was 48% of the young response (*p* = 0.002), increasing to 51% following training (*p* = 0.004) -- a cumulative reduction of 2.4% of the deficit. HIIT also reduced basal unstimulated ROS production ([Figure 1F](#F1){ref-type="fig"}: *p* = 0.023, 95%


increasing to 80% following training (*p* = 0.088) -- a cumulative reduction of 33% of the deficit. The bioenergetic health index (BHI) is a composite index of mitochondrial functions ([@B33]). HIIT increased BHI ([Figure 2E](#F2){ref-type="fig"}: *p* = 0.031, 95% CI −1.92, 0.083, *d* = 1.46), which at baseline was 13% of the young response (*p* \< 0.001), increasing to 65% following training (*p* = 0.058) -- a cumulative reduction of 51.6% of the deficit. HIIT increased mitochondrial membrane potential, ΔΨm ([Figure 2F](#F2){ref-type="fig"}: *p* = 0.011, 95% CI −0.23, −0.042, *d* = 1.10), which at baseline was 84% of the young response (*p* = 0.048), increasing to 98.5% following training (*p* = 0.817) -- a cumulative reduction of 14.3% of the deficit.

![Neutrophil mitochondrial health as assessed by basal respirationΔΨm improvements were also associated with increases in ATP production and lower proton leak. Future research should aim to understand the relationships with exercise training and neutrophil bioenergetics in order to determine the precise mechanisms by which exercise provides enhanced functions.

HIIT and Inflammation in Prediabetes {#S4.SS3}
------------------------------------

Although the underlying pathogenesis of prediabetes and type 2 diabetes is considered to include tissue exposure to chronic inflammation, we did not observe any changes for typical inflammatory measures following HIIT. Considering the majority of exercise studies that robustly alter plasma cytokines and acute phase protein levels are associated with weight loss, this did not come as a surprise. Indeed, in our previous studies in patients with RA and sedentary healthy adults where we observed minimal weight loss following HIIT, we did not


Commission Directive 2010/69/EU. Therefore, rosemary products can be a useful functional ingredient for the production of new functional foods \[[@B11-molecules-25-03711]\].

Mostly used conventional extraction (CE) techniques are often associated with long extraction time, use of organic solvents in huge amounts and possible thermal degradation of thermosensitive compounds such as antioxidants \[[@B12-molecules-25-03711]\]. For that reason, various innovative methods have been developed that are within the principles of green extraction processes. Apart from solvent extraction and steam distillation techniques, rosemary extracts have already been prepared by several green extraction methods: ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE) \[[@B13-molecules-25-03711],[@B14-molecules-25-03711]\], supercritical fluid extraction (SFE) \[[@B15-molecules-25-03711],[@B16-molecules-25-03711],[@B17-molecules-25-03711]\], and pressurized liquid extraction (PLE) \[[@B18-molecules-25-03711],[@B19-molecules-25-03711],[@B20-molecules-25-03711]\]. For example, UAE was used for extraction of bioactive compounds from dried rosemary. Increased recovery of carnosic acid was obtained in ethanol, whilethe HVED treatment and the maximum elevation of 5.9 °C was noted with sample RA5. In average, extracts treated for 9 min had 1 °C higher final temperature compared to extracts treated for 3 min. Also, maximum temperature was 29.5 °C after HVED treatment and it can be concluded that no significant elevation in temperature was noted during HVED treatment. Since all temperatures were under 30 °C, HVED was confirmed as a non-thermal extraction method. Results of pH for all extracts variated between 5.57 and 6.54 and no significant changes in pH were observed during the HVED treatment. pH and conductivity significantly depended (*p* ≤ 0.05) only on ethanol content. With higher content of ethanol in the solution, pH increased and conductivity decreased for both extraction types that


h values under CIE---L\*a\*b\* color system. According to the results, HVED treated samples had lower values of L\* (darker), a\* (more green), and higher values of parameter b\* (more yellow) when compared to CE in same conditions ([Table 4](#molecules-25-03711-t004){ref-type="table"}). The HVED extraction also caused increasing in parameter C resulting with increase and discernible difference in color intensity and slight increase in hue of extracts. Differences with untreated extracts are expressed as ΔE---total color difference, ΔC---difference in tone color; ΔH---saturation. Based on these data with more intense coloring of HVED extracts (mass and the solvent used were equally as with CE), it can be concluded that HVED treatment had damaged the cell structure and that the pigments contained within the plant cells exited the cell surface causing changes inextract color \[[@B47-molecules-25-03711]\]. Since the cavitation is caused, the process of extraction of BACs is also facilitated \[[@B48-molecules-25-03711]\]. In our study, ethanol content had significant effect on color parameters (L\*, a\* and b\*) in rosemary HVED treated samples with both argon and nitrogen. All colorimetric parameters, except ΔH, had statistically significant dependence (*p* ≤ 0.05) on ethanol content---with higher ethanol content, parameters L, ΔC, and ΔE increased, while a\*, b\*, C, and h decreased. Saturation significantly depended on treatment time and gas used, more saturation was noted with longer treatment time and use of nitrogen during the treatment.

In general, results indicated that HVED extracts had dark greenish-brown color with darker color when compared to CE which is associated also with higher phenolic compounds and antioxidant content. Plasma reactive


and cost- saving method for successful extraction of phenolic compounds from rosemary. However, further analysis of energy and environmental impact should be performed. Hirondart et al., (2020) have obtained rosmarinic acid, carnosic acid, and carnosol by PLE in hydroalcoholic solution and conventional Soxhlet extraction. Extract yields of bioactive compounds were similar with both methods, energy consumption was lower for PLE extraction because less solvent had to be heated, and the cost was reduced with a smaller amount of waste generated \[[@B51-molecules-25-03711]\].

When compared with theoretical results, it is clear that a similar trend for solution in water and ethanol was noticed. With higher ethanol content, solubility of most of extracted compounds increased, as well as a sum of all phenolic compounds. According to HSP results, all compounds that wereaccording to EC Regulations No. 396/2005 for rosemary as a plant. In EC regulation MRL of some pesticides with similar structures (such as DDT, endosulfan, aldrin, heptachlor, etc.) are grouped.

Residue levels of Lead (Pb) and Cadmium (Cd) in dried rosemary leaves were also below the limit of quantitation of the method, and only the level of Mercury (Hg) was slightly higher than limit of quantitation. However, all these values were quite below MRL according to EC No. 1881/2006. Furthermore, other metals (Chromium (Cr), Nickel (Ni), Manganese (Mn), Iron (Fe), Copper (Cu), and Zinc (Zn)) were measured in selected HVED extracts with high phenolic and antioxidant content (RA8, RN7, RN9, and RN11) as well and results are presented in [Table 7](#molecules-25-03711-t007){ref-type="table"}. These metals are not included in EC Regulations


so no MRL data were provided. Although the data should not be compared since data before the HVED extraction are given per g of dried herb and data after HVED extraction are given per gram of extract, it is clear that content of Cr and Ni increased in extracts, while level of other metals decreased after HVED extraction. From this data it is notable that during the HVED treatment, levels of some toxic metals are increasing that could be the result of abrasion of electrodes during the treatment.

Rosemary plant was compliant regarding content of contaminants, pesticide residues and toxic metals. With respect to this, obtained results showed that rosemary samples are safe for use in human dietary. On the other hand, some changes in levels of metals couldextracts or methanol solution of Trolox (25--200 mM) was mixed with 1.5 mL of 0.5 mM DPPH methanolic solution. After mixing, the solutions were stored in the dark for 20min at room temperature and the absorbance was measured at 517 nm against 100% methanol as a blank. The results were calculated using calibration curve for Trolox and expressed as µmol of Trolox equivalents per gram of sample (µmol TE/g of sample).

### 4.4.3. Ferric Reducing Antioxidant Power (FRAP) Assay {#sec4dot4dot3-molecules-25-03711}

The FRAP assay was conducted according to literature \[[@B59-molecules-25-03711]\] with modifications. The FRAP reagent was prepared by mixing 0.3 M acetate buffer (pH 3.6) with 10 mM TPTZ solution and 20 mM FeCl~3~ solution in ratio 10:1:1. An aliquot (80 μL) of rosemary extract was mixed with 240 μL of


C18 100 Å, 100 × 4.6 mm (column), thermostat column temperature 40 °C, automatic sampling temperature 4 °C, and injection volume of 10 μL. Mobile phases consisted of: A 100% H~2~O with 0.1% HCOOH (*v*/*v*) and B 100% acetonitrile with 0.1 % HCOOH (*v*/*v*) with mobile phase flow 0.40 mL/min. Gradient was set as follows: 1 min 10% B, 2 min 10% B, 15 min 90% B, 25 min 90% B, 27 min 10% B, 30 min 10% B. Determination conditions for MS/MS detector were: ionization -negative ionization mode atmospheric pressure (API)---negative ionization at atmospheric pressure; ionization temperature: 500 °C, i.e., gas temperature combining the mobile phase at the exit from the capillary before ionization. Voltage on the electrode after capillary and next to ionization (Ion Spray Voltage)was −4500 V.

### 4.4.7. Headspace Solid-Phase Microextraction (HS--SPME) Followed by Gas Chromatography and Mass Spectrometry Analysis (GC--MS) {#sec4dot4dot7-molecules-25-03711}

HS--SPME was performed with a manual SPME holder using three fiber covered with DVB/CAR/PDMS obtained from Supelco Co. (Bellefonte, PA, USA). For HS--SPME, the finely samples 2 mL were placed separately in 10 mL glass vials and hermetically sealed. The vials were maintained at 60 °C during equilibration (15 min) and extraction (45 min). Thereafter, the SPME fiber was withdrawn and inserted into GC--MS injector (250 °C) for 6 min for thermal desorption. The procedure was similar as in previous paper \[[@B62-molecules-25-03711]\].

Gas chromatography and mass spectrometry (GC--MS) analyses were done on an Agilent Technologies (Palo Alto, CA, USA) gas chromatograph model 7890A equipped with a mass spectrometer (MSD) model 5977E (Palo


of HBV nucleocapsids could be deleted without interfering with the protein's ability to assemble into virus-like particles. It is thus reported that proteins truncated to about position 144; i.e., containing the HBc sequence from position one through about 144, can self-assemble, whereas deletions beyond residue 139 abrogate capsid assembly [Birnbaum et al., (1990) J. Virl., 64:3319-30].
Zlotnick et al., (1997) Proc. Natl. Acad. Sci., USA, 94:9556-9561 studied the assembly of full length and truncated HBc proteins in to particles. In addition to discussing full length molecules, those authors reported the preparation of a truncated protein that contained the HBc sequence from position 1 through 149 in which the cysteines at positions 48, 61 and 107 were each replaced by alanines and in which a cysteine residue was added atlong-term storage.
The above four published PCT applications appear to contain teachings that can be used to overcome over come the potential problems disclosed by Ulrich et al. As disclosed hereinafter, the present invention provides another HBc chimer that provides unexpectedly high titers of antibodies against influenza, and in one aspect also provides a solution to the problems of HBc chimer stability as well as the substantial absence of nucleic acid binding ability of the construct. In addition, a contemplated recombinant chimer exhibits reduced antigenicity toward preexisting anti-HBc antibodies.
The above particle instability findings related to N-terminal truncated HBc chimer molecules notwithstanding, Neirynck et al., (October 1999) Nature Med., 5(10):1157-1163 reported that particle formation occurred on E. coli expression of a HBc chimer that contained the N-terminal 24-residue portion of


particle formation [Schodel et al. (Jan. 15, 1993) J. Biol. Chem., 268(2):1332-1337; Wasenauer et al. (March 1993) J. Virol., 67(3):1315-1322; and Nassal et al. (July 1993) J. Virol., 67(7):4307-4315]. All three groups reported that in wild type HBeAg, the cysteine residue at position −7 of the pre-core sequence, which is present when the core gene is translated from an upstream initiator methionine at position −30, is responsible for preventing particle formation and therefore facilitating the transition from particulate HBcAg to secreted, non-particulate HBeAg.
Based upon the above three publications, one would expect the inclusion of one or more cysteine residues at a position prior to the initiator methionine of HBc; i.e., at a residue position of less than one relative to the N-terminus of the sequence of SEQ IDBitcoin Creator Satoshi Nakamoto

However, we are journalists. We have to report on the fact that a prominent BCH developer is now appearing to claim the name Satoshi Nakamoto. Certain questions arise as to the nature of Sechet’s wealth. For one thing, if he’s Satoshi Nakamoto and he doesn’t believe in Bitcoin Core anymore, why not just cash in his billions and pump the Bitcoin Cash price?

For his part, the last person to publicly claim he was Satoshi Nakamoto was bitter about the idea:


here are my ground rules:

1. As a parent, you CANNOT be 'too involved' when it comes to knowing where your kids are and with whom. Right now they should be honing their decision making skills with your assistance, not turned loose to do as they please. They'll have years of adulthood to exhibit their independence.

2. It is never wrong to ASK QUESTIONS or to expect your child to check in/stay in touch. And when you call their cell phone and they don't answer, there SHOULD be consequences!

3. Kids are going to fib and they're going to make poor decisions. It's a matter of fact because they must test the limits from time to time. Life is a learning process and no matter how wonderful you know your kidsanalysis (PCA) can be used as an effective and economic method to evaluate the quality of Chishao, and may be extended to other Chinese medicinal plants. Due to the complex basis of the efficacy of Traditional Chinese Medicine (TCM), the method such as PCA of several chemical components appears to be a more appropriate method for the quality evaluation of TCM in contrast to the determination of a single or few chemicals.


spokesman Lu Kang said at a regular press briefing.
But he warned that foreign nationals, including UN officials and experts, should avoid interfering in China’s internal affairs.
China’s foreign ministry regularly claims it welcomes visits to Xinjiang from foreign journalists and officials.
But foreign journalists travelling to the region are frequently detained and followed by police to prevent and obstruct reporting on the internment camps and treatment of Uighurs.
China has long imposed draconian restrictions on the lives of Muslim minorities in the region in the name of combating terrorism and separatism.
But police measures have intensified in recent years, and an independent UN panel believes as many as one million ethnic Uighurs and other Turkic Muslim minorities are being held in re-education centres.
Activists say ethnic minorities can be detained for transgressions asData from the 1997 U.S. Department of Agriculture (USDA) National Agricultural Statistics Service (NASS) Census of Agriculture were used to obtain information on both the acres of cropland and acres of land planted in six leading U.S. crops (barley, corn, cotton, oats, soybean, and wheat) in each of the counties in the study population ([@b39-ehp0116-000559]). This periodic census is the most thorough source of U.S. agricultural data from the county, state, and national level. We chose the 1997 census because it was conducted at the approximate midpoint of our incidence data. Of the 29 eligible state registries originally available for this study, no county identifiers were available for three and no NASS data were available for one. Eight of the state cancer registries did not have data available


   1.0 (0.9--1.1)    1.1 (0.9--1.3)     0.9 (0.8--1.1)   1.1 (0.9--1.4)
   Lymphoid leukemias                                                  1.1 (0.8--1.6)    0.4 (0.1--1.0)      1.0 (0.9--1.1)    1.4 (1.2--1.6)    1.0 (0.8--1.1)    1.1 (0.9--1.4)     1.0 (0.8--1.1)   1.3 (1.1--1.7)
   Acute myeloid leukemias                1.3 (0.9--1.7)   1.6 (0.9--2.7)
  Sympathetic nervous system                                           1.0 (0.8--1.3)    1.8 (1.3--2.5)      1.2 (1.0--1.4)    1.8 (1.4--2.4)    1.3 (0.9--1.9)    1.2 (0.6--2.3)     1.3 (0.7--2.3)   1.3 (0.5--3.6)
   Neuroblastomas


Q:

Plesk 10 - creating and using vhost.conf

I'm having some issues setting up and using a vhost.conf for one of my domains. So far none of the domains have required any extra configuration but now I need to use a PEAR module, so I'm looking to include /usr/share/pear in the PHP settings for the domain.
vhost file created in /var/www/vhosts/domain.com/conf/vhost.conf
<Directory /var/www/vhosts/domain.com/httpdocs>
 php_admin_value include_path ".:/usr/share/pear"
</Directory>

I then restart Plesk using:
/usr/local/psa/admin/sbin/websrvmng --reconfigure-vhost --vhost-name=domain.com

Or as plesk says that command is obsolete in Plesk 10 I've tried using
/usr/local/psa/admin/sbin/httpdmng --reconfigure-domain domain.com

And for good luck I've restarted apache too each time. Net result - none of the PEAR includes work unless I edit the include_path in /etc/php.ini!
Any tips on how to get this MOFO working? I've had a look through the documentation but TBH I just don'tthe same protocol after the 6-week exercise by the same physiotherapist.

The neck exercise group received a corrective exercise program for forward head posture in the form of two strengthening (deep cervical flexors and shoulder retractors) and two stretching (cervical extensor and pectoral muscles). Participants completed three sets of 12 repetitions of the strengthening exercise and three stretching exercises held for 30 seconds ( Harman et al., 2005 Diab, 2012 ).

A horse riding simulator was used for the experiment in this study. It is created movements similar to a horse, and an indoor HRS H-702 (Honjin, Korea). Subjects had 5 minutes to prepare. After the start of horse riding exercise, the participants based their abilities to adjust speed.

Subjects were randomly divided into two groups of 15 subjects each, were


mental health crisis, people in constant relentless pain. People who can’t always fight back.

As someone who is negotiating a reduction in hours to hang on to what physical & mental health that’s left, this is scary. The argument behind insisting that people with disabilities work is to give a purpose and improve mental health. Well my dear Tory MPs, let me give you some cold hard facts.
I love my job, but pushing through regardless has directly caused some very dark thoughts. And I am infinitely lucky to have the husband that I do because he listens every time I need to shout my frustrations at the world. Most people wouldn’t have the patience. (You, by the way, don’t deem him to be a carer despite dressing me everysigns early on. I’m too stubborn to give in. Mr Geek deserves a medal.Research is important for all conditions.

Right now, I’m in a lot of pain. My hip subluxes daily, my pelvis dislocates as much, my knees & shoulders dislocate more often than I’d like, my back is a weird shape as the discs degenerate, my hands vary from ok to weird bendy claws. I sound like a bowl of rice crispies! I take painkillers, but my body is resistant to their effects, so the dosage I need makes my head fuzzy. The number of times my lower back & SI have moved has damaged the nerves to an extent where I can’t feel my feet anymore & on occasions go full ‘floppy leg’. Nerve function also interferes


sure I’m totally ready to use the chair at home. I can see why it would help, but it’s a bit scary. I may try the manual one inside for a while just to get used to doors and stuff. Hey, it may let me stay up for a bit longer in the evening rather than going to bed at the same time as the kids!

This all actually happened yesterday but I was too tired and in pain to write. I’m coasting on my painkillers which just aren’t cutting it for working full time. I’m struggling to find something actually effective and it’s a long old road with the GP to find the right one. For now I’m sticking with combining dihyrocodeine and co-codamol as a cocktail with<?xml version="1.0" encoding="utf-8"?>
<root>
  <!--
    Microsoft ResX Schema

    Version 2.0

    The primary goals of this format is to allow a simple XML format
    that is mostly human readable. The generation and parsing of the
    various data types are done through the TypeConverter classes
    associated with the data types.

    Example:

    ... ado.net/XML headers & schema ...
    <resheader name="resmimetype">text/microsoft-resx</resheader>
    <resheader name="version">2.0</resheader>
    <resheader name="reader">System.Resources.ResXResourceReader, System.Windows.Forms, ...</resheader>
    <resheader name="writer">System.Resources.ResXResourceWriter, System.Windows.Forms, ...</resheader>
    <data


import sys, traceback, string

from win32com.axscript import axscript
from win32com.axdebug import codecontainer, axdebug, gateways, documents, contexts, adb, expressions
from win32com.axdebug.util import trace, _wrap, _wrap_remove

import pythoncom
import win32api, winerror
import os

currentDebugger = None

class ModuleTreeNode:
    """Helper class for building a module tree
    """
    def __init__(self, module):
        modName = module.__name__
        self.moduleName = modName
        self.module = module
        self.realNode = None
        self.cont = codecontainer.SourceModuleContainer(module)
    def __repr__(self):
        return "<ModuleTreeNode wrapping %s>" % (self.module)
    def Attach(self, parentRealNode):
      sys.modules[parent]
            BuildModule(parentModule, built_nodes, rootNode, create_node_fn, create_node_args)
            if parentModule in built_nodes:
                parentNode = built_nodes[parentModule].realNode
        node.Attach(parentNode)

def RefreshAllModules(builtItems, rootNode, create_node, create_node_args):
    for module in list(sys.modules.values()):
        BuildModule(module, builtItems, rootNode, create_node, create_node_args)

# realNode = pdm.CreateDebugDocumentHelper(None) # DebugDocumentHelper node?
# app.CreateApplicationNode() # doc provider node.

class CodeContainerProvider(documents.CodeContainerProvider):
    def __init__(self, axdebugger):
        self.axdebugger = axdebugger
        documents.CodeContainerProvider.__init__(self)
        self.currentNumModules = len(sys.modules)


root = app.GetRootNode()
        return app, root

    def CloseInterfaces(self, pdm):
        pdm.RemoveApplication(self.cookie)

class SimpleHostStyleInterfaceMaker:
    def MakeInterfaces(self, pdm):
        app = pdm.GetDefaultApplication()
        root = app.GetRootNode()
        return app, root

    def CloseInterfaces(self, pdm):
        pass

class AXDebugger:
    def __init__(self, interfaceMaker = None, processName = None):
        if processName is None: processName = "Python Process"
        if interfaceMaker is None: interfaceMaker = SimpleHostStyleInterfaceMaker()

        self.pydebugger =Strong, Comprehensive Support for Healthy Blood Pressure!

Put It To the 90-Day Test!

Results guaranteed or we’ll buy it back.

I’m very excited to introduce my BP Essentialsformula. It gives you the research doses of some of the strongest nutrients nature has to offer for maintaining healthy blood pressure—supporting everything from normal blood volume to the elasticity of your blood vessels.

I believe so strongly in the power of these nutrients that I’m willing to guarantee your satisfaction. I encourage you to try BP Essentials and stick with it for at least 90 days. If at any time (even after 90 days) you’re not thrilled with the results, just send it back for a full refund of the purchase price. That’s my personal promise to you.

Side Effects:There are no known side effects


maxima, for which $A(t)\ll 1$ and $p_{2\parallel}\simeq 0$. Hence, the momentum-space conditions for which ionization of the second electron is most probable lie approximately at $(p_{2\parallel },p_{2\perp })=(0,0)$. For a few-cycle pulse, depending on the specific tunnel ionization event, the barrier will be narrower or wider.

In summary, the constraints upon the momentum of the second electron determine the position of the cross-shaped distributions at the axes $p_{n\parallel}=0$ in the parallel-momentum plane, while those related to the momentum of the first electron determine the regions along these axes that will be populated, i.e., whether they will be long or short. Clearly, for a few-cycle pulse this length will vary with each particular event.

Quantum-orbit analysis {#orbitspulse}
======================

In this section, we will perform a quantum-orbit analysis of the problem, with emphasis onall features encountered can be explained in terms of electron trajectories. Indeed, a detailed analysis of where these trajectories are located within the pulse, and, in the context of the steepest descent method, of the real and imaginary parts of the ionization times of both electrons and the rescattering time of the first electron provide a consistent picture related to the shapes, maxima and regions populated by the RESI electron-momentum distributions. All such features are determined by the interplay between the dominant sets of trajectories for the first and second electron.

Qualitatively, the results in the present publication agree with those observed experimentally in [@Bergues2011], in which it has been reported that, depending on the CEP, the electron-momentum distributions shift from the region below to the region above the


Q:

Remove last segment of Request.Url

I would like to remove the last segment of Request.Url, so for instance...
http://www.example.com/admin/users.aspx/deleteUser

would change to
http://www.example.com/admin/users.aspx

I would prefer linq but accept any solution that efficiently works.

A:

Use the Uri class to parse the URI - you can access all the segments using the Segments property and rebuild the URI without the last segment.
var uri = new Uri(myString);

var noLastSegment = string.Format("{0}://{1}", uri.Scheme, uri.Authority);

for(int i = 0; i < uri.Segments.Length - 1; i++)
{
   noLastSegment += uri.Segments[i];
}

noLastSegment = noLastSegment.Trim("/".ToCharArray()); // remove trailing `/`

As an alternative to getting the scheme and host name, as suggested by Dour High Arch in his comment:
var noLastSegment = uri.GetComponents(UriComponents.SchemeAndServer,
                                     UriFormat.SafeUnescaped);

A:

Much the same as @Oded's answer, but using a UriBuilder instead:
var uri = new Uri("http://www.example.com/admin/users.aspx/deleteUser");
var newSegments = uri.Segments.Take(uri.Segments.Length - 1).ToArray();
newSegments[newSegments.Length-1] =
    newSegments[newSegments.Length-1].TrimEnd('/');
var ub=new UriBuilder(uri);
ub.Path=string.Concat(newSegments);
//ub.Query=string.Empty;  //maybe?
var newUri=ub.Uri;

A:

To remove the last segment of Request.Url it is enough to subtract from absolute uri the length of last segment.
string uriWithoutLastSegment = Request.Url.AbsoluteUri.Remove(
  Request.Url.AbsoluteUri.Length - Request.Url.Segments.Last().Length );


Q:

Can the ItemAdding event be used in a Sandbox?

Can the ItemAdding event be used in a Sandbox?
I need to perform a task when a Item is a added/adding, it has to be synchronous (item added is async so i cant use that).
If i cant use the ItemAdding what other options do i have?

A:

Yes, it is possible (see here too http://msdn.microsoft.com/en-us/library/microsoft.sharepoint.spitemeventreceiver.itemadded(v=office.14).aspx), however you would need to be aware of some tips, such as:

make sure you don't use any RunsAsPrivilegedUser
debugging always by attaching to SPUCWorkerProcess

ActionResult DisplayCustomerView(CustomerModel customerModel)
    {
      var myView = View("DisplayCustomerView", customerModel);
      //myView.ViewName = "DisplayCustomer";
      return myView;
    }

}
}

Edited Unit Test:
using System;
using System.Text;
using System.Collections.Generic;
using System.Linq;
using Microsoft.VisualStudio.TestTools.UnitTesting;
using Mvccustomer.Models;
using Mvccustomer.Controllers;
using System.Web.Mvc;

namespace MvcUnitTest
{

[TestClass]
public class UnitTest1
{
    [TestMethod]
    public void DisplayCustomer()
    {
      // instantiates new instance of CustomerController class
      CustomerController controller = new CustomerController();

      var customer = new CustomerModel();

      var customerViewActionResult = controller.DisplayCustomerView(customer);
      var customerViewViewResult = customerViewActionResult as ViewResult;

      Assert.AreEqual("DisplayCustomerView", customerViewViewResult.ViewName);

    }
}
}

A:

You are calling


       if (is_null($todo)) {
                return Response::json('Todo not found', 404);
            } else {
                return Response::eloquent($todo);
            }
        }
    }
}

How to recognise get parameter using "?" ?

A:

Take a look at the $_GET and $_REQUEST superglobals. Something like the following would work for your example:
$start = $_GET['start'];
$limit = $_GET['limit'];

EDIT
According to this post in the laravel forums, you need to use Input::get(),AMERICAN INDIAN HERITAGE MONTH

Proclamation

November 1, 2013

WHEREAS, the 2010 US Census data indicates North Carolina is home to more than 122,000 American Indians, the largest American Indian population east of the Mississippi River; with 14,000 years of Indians and tradition: we’re still here; and

WHEREAS, American Indians stand among America's most distinguished authors, artists, scientists, and political leaders, and in their accomplishments, they have profoundly strengthened the legacy we will leave our children; we’re still here; and

WHEREAS, American Indians and Alaska Natives bravely fought to protect this legacy as members of our Armed Forces; as service members, they have shown exceptional valor and heroism on battlefields from the American Revolution to the Iraq and Afghanistan conflicts, we’re still here; and

WHEREAS, American Indians have demonstrated time and again their commitment to


Monoclonal anti-myelin associated glycoprotein (MAG) antibodies in patients with mixed sensory-motor polyneuropathies occurring in association with IgM gammopathy (paraproteinemia) are all directed toward carbohydrate epitopes in MAG and cross react with other glycoproteins of PNS myelin including PO and PMP-22 as well as with the glycosphingolipid, sulfate-3-glucuronyl paragloboside (SGPG). In order to gain insights about the pathogenic mechanisms involved, we are biochemically analyzing an animal model of this disease involving passive transfer to chickens by infusion of human anti-MAG antibodies and which exhibits pathohistological similarities to the human disease. Preliminary results show that all myelin proteins are decreased, but small doses produce a greater effect on MAG than other potential glycoprotein targets. Monoclonal antibodies that are MAG/SGPG-negative in patients with gammopathy and neuropathy frequently react with ganglioside antigenshave shown that replacing the usual polylysine substratum with basement membrane (Matrigel), laminin or type IV collagen causes a specific increase in the incorporation of radioactive galactose into the major GM3 ganglioside of the cells and some complex neutral glycosphingolipids, without a similar increase in the synthesis of other lipids, proteins or glycoproteins. The enhanced GM3 synthesis is associated with increased Schwann cell proliferation, and an inhibitor of synthesis of GM3 and the other glycolipids (PDMP) also inhibits basement membrane induced proliferation, suggesting that the increased synthesis may be functionally involved in the proliferative response. The results also show that the Schwann cell response to basement membrane alone is quite different from that which occurs in the presence of neurons, in which case the cells will differentiate and


Emojis: Insights, Affordances, and Possibilities for Psychological Science.
We live in a digital society that provides a range of opportunities for virtual interaction. Consequently, emojis have become popular for clarifying online communication. This presents an exciting opportunity for psychologists, as these prolific online behaviours can be used to help reveal something unique about contemporary human behaviour.Characterization of a new spontaneously developed murine mammary adenocarcinoma in syngeneic BALB/c hosts.
A mouse mammary tumor cell line, designated JC, has been established from a spontaneously developed primary adenocarcinoma of an aged virgin female BALB/c mouse. Isoenzyme analyses including glucose-6-phosphate dehydrogenase, lactate dehydrogenase, and peptidase proved that this cell line is of murine origin and devoid of contamination from other species. Karyotyping revealed that the number of chromosome ranged from 26 to 100, with a modal number of 40. Electron microscopic examination detected the presence of tonofilament and desmosomes confirming its epithelial nature. In addition, no type B or C virus particle was detected, although intracysternal A particle was observed occasionally. Tumorigenicity in immunocompetent syngeneic hosts was easily established by s.c., i.p., and i.v. injection of viable JC


keen attention to Hans Christian Andersen’s image of the swarm of white bees. Do you know what emotion or idea drew you to the bees?

We were excited to consider how a “white bee” might be structured in contrast to the branching six-arm crystals of snowflakes, which are geometrically determined by temperature and humidity within the immediate surroundings. Unlike snowflakes, a flurry of “white bees” grows and swarms in response to the disposition of the Snow Queen. She not only controls changes within the immediate climatic atmosphere, but, through forces akin to magnetic fields, she creates a radiating cloak of variable density and direction. A “white bee” develops three dimensionally, biased towards forces of attraction and repulsion, as opposed to the symmetrical plate formations of snowflakes.

In our architectural work,the Hive Lantern your firm designed. Can you describe any of the images for “The Snow Queen” as possible products?

Our hope was to actually take the bee swarm as far as a gown fit for a queen! We were extremely inspired by the gorgeous digital explorations of Neri Oxman, in which synthetic biological formations engage the human figure.

In our work, while there are cues taken from biological or more general environmental formation and pattern, there also is a bias to work through analog methodologies. While we speculated on the structure of a “white bee” through analysis of similar molecular structures, the final aesthetic principles are obviously the results of a process dictated by hand. In this way, the process for creating the “white bee” is more similar to


$.

Now a question arises; how is a propagator in a general orbifold $ M/G $ constructed? Here $ M $ is a Riemannian manifold and $ G $ is a compact Lie group that acts on $ M $ by isometry. Such an example is easily found; we may take $ M = {\mathbf{S}}^2 $ and $ G = U(1) $. Then the quotient space is $ M/G = [-1,1] $, which has two boundary points.

Let us turn to another aspect of the propagator, namely, the path-integral expression of the propagator. For the general Schr[ö]{}dinger equation $$i \frac{\partial}{\partial t} \phi(x,t)
    = H \phi(x,t)
    = - \frac{1}{2} \frac{\partial^2}{\partial x^2} \phi(x,t)
    + V(x) \phi(x,t),
    \qquad x\psi = \psi
    \}.
    \label{invariant space}$$ A set $ \{ e^\chi_1, \dots, e^\chi_d \} $ is an orthonormal basis of $ {\cal H}^\chi $. Then the [*reduction operator*]{} $ S^\chi_i : {\cal H} \to ({\cal H}^\chi \otimes {\cal H})^G $ is defined by $$f \in {\cal H} \mapsto
    S^\chi_i f
    :=
    \sqrt{d^\chi} \int_G {\mathrm{d}}g \,
    ( \rho^\chi(g) e^\chi_i ) \otimes ( T(g) f ).$$\
[**Theorem 2.1.**]{} [*$ S^\chi_i $ is a partial isometry. Namely, $ (S^\chi_i)^* S^\chi_i $ is an orthogonal projection operator acting on $ {\cal H} $ while $ S^\chi_i (S^\chi_i)^* $ is the identity operator on $ ({\cal H}^\chi \otimes {\cal H})^G $.* ]{}\
[**Theorem 2.2.**]{} [*The family


a little loveLea

Tuesday, August 14, 2012

Just a quick update! We have been working tirelessly on our old house (yes, I'm channeling "This Old House") replacing windows and trim. Of course we then have to paint the lovely new trim. Hubby and I have really separate duties for this home update obviously. Unfortunately, I was up until 1am completing my assigned tasks. Blah. You are only getting a small preview tonight.

Tuesday, August 7, 2012

It has been over a year since my last post! I have tried to come back to you so many times- only to feel that this blog thing was just a little too complicated for me (ugh). Well, I'm over it. Things are going to look squirrel-y on this little ladie's blog because she (I'm referringor so but hey, it's a start! I found this cute little idea on ProjectWedding.com (tutorial included in link) and thought it would work just perfectly to let our guests know that were finally gettin hitched! Woo Woo! I did however, customize it to my liking and ever-developing theme by using burlap material for the hearts and a turquoise colored ribbon. These would be super cute for just about anything and maybe even sweet party favors too!

Friday, February 18, 2011

I managed to make my first silhouette out of a photo by using GIMP which is totally F-R-E-E and a lot like Photoshop!! It took me a little while to get the hang of it but I think my first try was a success! Let me know what you


4*k**2
Let h(q) = 850*q. Let b(a) = 332154*a**2 - 2. What is b(h(i))?
239981265000*i**2 - 2
Let k(z) = 3*z**2. Let f = 46 + -46. Let t be (-184)/(-2) + f/(-5). Let p(a) = -48*a + t*a - 50*a. What is p(k(x))?
-18*x**2
Let f(w) be the third derivative of -w**4/6 + 103*w**2 + 6*w. Let q(a) = -7 + 8 - 21*a - 1. Determine f(q(z)).
84*z
Let v(x) = -65*x + 241*x - 58*x + 1376 - 57*x - 62*x. Let o(h) = 3*h**2. Calculate v(o(g)).
-3*g**2 + 1376
Let o(a) = -3*a. Suppose -1063 = -5*f - 343. Let y(x) = f*x - 295*x + 12*x**2 + 150*x. Calculate y(o(r)).
108*r**2 + 3*r
Let l(s) = -386495*s**2. Let p(m) = 417*m. Give p(l(r)).
-161168415*r**2
Let h(l) = -3*l + 21. Let u(b) = -3*b + 14.Let y(u) = 16*u + 12. Let j(i) = 3*p(i) - 154*y(i). Let o(l) = 112*l + 2. What is j(o(f))?
-2464*f - 44
Let v(y) = -3*y**2. Suppose -7*u + u = -18. Suppose 0 = i + 3*t - 8*t - 30, 5*i = u*t + 62. Let k(c) = -8 - i*c + 15*c + 8. What is v(k(s))?
-75*s**2
Let g(d) = 34913*d.


userspace may decide to not read
		 * any data after poll'ing.
		 * We should respond to further attempts from the device to send
		 * data, so that we can get unstuck.
		 */
		service_outstanding_interrupt(desc);
	}

	spin_unlock(&desc->iuspin);
}

static void wdm_int_callback(struct urb *urb)
{
	int rv = 0;
	int responding;
	int status = urb->status;
	struct wdm_device *desc;
	struct usb_cdc_notification *dr;

	desc = urb->context;
	dr = (struct usb_cdc_notification *)desc->sbuf;

	if (status) {
		switch (status) {
		case -ESHUTDOWN:
		case -ENOENT:
		case -ECONNRESET:
			return; /* unplug */
		case -EPIPE:
			set_bit(WDM_INT_STALL, &desc->flags);
			dev_err(&desc->intf->dev, "Stall on int endpoint\n");
			goto sw; /* halt is cleared in work */
		default:
			dev_err(&desc->intf->dev,
				"nonzero urb status received: %d\n", status);
			break;
		}
	}

	if (urb->actual_length < sizeof(struct usb_cdc_notification)) {
		dev_err(&desc->intf->dev, "wdm_int_callback - %d bytes\n",
			urb->actual_length);
		goto exit;
	}

	switch (dr->bNotificationType) {
	case USB_CDC_NOTIFY_RESPONSE_AVAILABLE:
		dev_dbg(&desc->intf->dev,
			"NOTIFY_RESPONSE_AVAILABLE received: index %d len %d\n",
			le16_to_cpu(dr->wIndex), le16_to_cpu(dr->wLength));
		break;

	case USB_CDC_NOTIFY_NETWORK_CONNECTION:

		dev_dbg(&desc->intf->dev,
			"NOTIFY_NETWORK_CONNECTION %s network\n",
			dr->wValue ? "connected to" : "disconnected from");
		goto exit;
	case USB_CDC_NOTIFY_SPEED_CHANGE:
		dev_dbg(&desc->intf->dev, "SPEED_CHANGE received (len %u)\n",
			urb->actual_length);
		goto exit;
	default:
		clear_bit(WDM_POLL_RUNNING, &desc->flags);
		dev_err(&desc->intf->dev,
			"unknown notification %d received: index %d len %d\n",
			dr->bNotificationType,
			le16_to_cpu(dr->wIndex),
			le16_to_cpu(dr->wLength));
		goto exit;
	}

	spin_lock(&desc->iuspin);
	responding = test_and_set_bit(WDM_RESPONDING,is corporate secretary for her family’s business, G.V. Burrows, Inc., and has a wealth of knowledge in making financial decisions, including budgets and purchasing, as well as employment decisions.

As a board member she has volunteered countless hours in fundraising and supporting various student activities including sports dinners, senior exit interviews, proctoring tests, orientation, and Sober Grad.

Jeanne was elected to the Lemoore High School District board of trustee’s in 2012 and again in 2014. She strives to do her best in making the correct decisions for the well-being of the students, staff and faculty of the district as well as for the community of Lemoore.

Term Novemeber 2018

Phone:

Email:

Degrees and Certifications:

Dr. Guadalupe Solis - Board President - Area 3

Dr. Guadalupe Solis has been a long time resident of Lemoore. Presently Dr.


a farm equipment business in Stratford that has been in his family for over 110 years.

Jason and his wife Christa have four children. Their oldest is a graduate of LHS and is attending BYU Idaho. Their youngest daughter attends LHS and their son will be attending LHS beginning 2017.

Jason volunteers as an Assistant Scoutmaster with Lemoore Troop 461, Boy Scouts of America and is a member of SHRM of Tulare/Kings Counties.to be clarified.

Terrestrial reptile remains are very rare in the Lower Cretaceous of South Australia, but include the holotype of the small theropod Kakuru. Here, we review this taxon and other archosaur specimens collected from the Bulldog Shale (Aptian) of Andamooka and Coober Pedy. Kakuru possesses no unique characters or character state combinations and is regarded as a nomen dubium, representing an indeterminate tetanuran theropod. Two other specimens (a left metatarsal and astragalus) can be referred to Dinosauria, but the identity of several other specimens (phalanges and a centrum) can only be resolved to the level of an indeterminate archosaur.

Since 2002 a number of sites containing stegosaurian remains (bones and tracks) have been discovered in the Villar del Arzobispo Formation (Tithonian–Berriasian) in the Province of Teruel, Spain, mostly


H. altispinus represents a relatively complete growth series that includes crestless juveniles of less than half the size of large individuals with fully developed crests. Cranial ontogeny is compared with other lambeosaurines using bivariate morphometrics and through qualitative comparison of a size-standardized cranial growth series. Bivariate analyses reveal that the relative growth of the skull and cranial crest of H. altispinus and H. stebingeri are similar, and that Hypacrosaurus more closely resembles Corythosaurus than Lambeosaurus. Hypacrosaurus altispinus is systematically revised. The taxon is characterized by five autapomorphies, most of which are concentrated in the skull, as well as an enlarged terminal ischial foot. Maximum parsimony and Bayesian likelihood (Mk+gamma) phylogenetic analyses were conducted to test the monophyly of the genus. Hypacrosaurus monophyly is corroborated in light of newLow-level laser therapy and myofacial pain dysfunction syndrome: a randomized controlled clinical trial.
Myofacial pain dysfunction syndrome (MPDS) is the most common reason for pain and limited function of the masticatory system. The effects of low-level lasers (LLLs) for controlling the discomfort of patients are investigated frequently. However, the aim of this study was to evaluate the efficacy of a particular source producing 660 nm and 890 nm wavelengths that was recommended to reduce of the pain in the masticatory muscles. This was a double-blind and placebo-controlled trial. Sixteen MPDS patients were randomly divided into two groups. For the laser group, two diode laser probes (660 nm (nanometers), 6.2 J/cm(2), 6 min, continuous wave, and 890 nm, 1 J/cm(2) (joules per square centimetre), 10 min, 1,500 Hz (Hertz)) were


follow-up. In both Infinity War and The Last Jedi, the heroes fail, but only one of the movies gives that failure a chance to sink in. The Last Jedi’s younger heroes, full of can-do spirit in The Force Awakens, get a chance to save the day in their follow-up adventure, and they blow it: Poe Dameron leads a mutiny that turns out to be unnecessary, and Finn and Rose’s side quest is a bust, at least in terms of hacking into an enemy ship’s tracking software. Even Luke Skywalker re-enters the story not as a hero full of wisdom to be passed on to the next generation, but as a man haunted by his past mistakes. We learn that in a moment of fear and despair, he cameclose to killing his dark-leaning nephew Kylo Ren (Adam Driver), inadvertently sending him further down a Vader-emulating path. The Last Jedi’s characters, both heroes and villains, struggle with whether the past can or should define them, and that past includes failures, not just chosen-one victories.

In Infinity War, failure is merely a plot device. Few of the movie’s characters go through any meaningful change—and that includes most of the characters who wind up dead. They start the movie wanting to stop Thanos, they try to stop Thanos, and they fail to stop Thanos (at least until next May). Their final failure isn’t something the characters grapple with for more than a few moments, and while the lack of falling action increases the shock value, it also blunts the movie’s


is

essentially limited to personal property and credit card and other unsecured debt incurred by

the parties individually. Our review of the record convinces us the court divided the property

and debt equitably, apportioning the debt to give each party responsibility for debts he or she

incurred.

¶7     Affirmed.

                                                           /S/ KARLA M. GRAY

We concur:

                 out that over the past decade there have been many Miocene Cristellaria I and Cibicides opima discoveries in south Louisiana, resulting from integration of detailed geology and advanced geophysical techniques.

“These discoveries, typically in a depth range of 13,000 to 15,000 feet, are in a geopressured environment, have excellent productive capabilities and high liquid content,” Frye said. “They can pay out in a few months.”

He noted many of these are AVO Class 2, where the sands are a bit faster than the shales when wet – but with density change and shear wave properties that come up and the difference in sonic velocity, they begin to look like bright spots that have been exploited on the Gulf shelf for many years.

Willis emphasized there are a number of deeper discoveries


think there’s still a lot of potential in south Louisiana, but it’s going to take deeper drilling to do it,” Frye said. “Once you get below 15,000 feet, the number of wells (drilled) drops off, and you have a lot more opportunities to find things that haven’t been tested.

“We’re following the trends,” he said. “Some continue right on offshore.

“By far the most active player in the deeper stuff has been McMoRan,” he noted, “with discoveries such as Flatrock, Mound Point and now Davy Jones.”It was inevitable. You cannot cross the Tranny Mafia and expect to remain a justice warrior in good standing. Peez knows that. So buh-bye Ophie, with a twist of the dagger (referring to his friend of a decade-and-a-half as "this person" is cold-blooded, even for Peez).

"trans-IDing males, regardless of HRT, are performing normally as males in their weight class."

Citation needed. In fact, here’s a nice little article packed solid with citations about why you’re wrong: https://sports.vice.com/en_ca/article/v ... ransitions .And can I just add: Fuck gmcard extra hard, in several directions with sharp objects, for the "likely pedophile" bit. Once again, bigots are claiming all gaytrans people are pedophiles, because it helps gin up the moral panic against the people they hate.
But hey, any story at all in service


heard that the reason why white people shouldn't be allowed to identify as black people is because they'll never truly understand the depths of oppression which comes from being black. Which is kind of idiotic, but okay. In any case, plenty of feminist women use the same tack: that a man shouldn't be allowed to identify as a woman because he'll never truly appreciate the depths of oppression wimminfolk have suffered at the hands of the patriarchy. Therefore, if you think otherwise, then you must not believe in the oppressive instruments wielded by males over females. Which is an inherently antifeminist position.

When it comes down to it, identity politics is a lot of complicated, nebulous, self-contradictory and idiotic shit, and I honestly don't understand why so many peopleto change the proportions in the population mix, and subsequently the culture, the power structure, economics, politics, *business practises etc. etc. etc. All of these things will change with it.

* One fellow I know was astounded that a guy who was stealing from the store he worked at was rewarded with his own store to manage (family owned chain) and then there was another fellow who boasted that his son tried to cheat him in a business deal. I could go on. But you get the picture.

You or your "tribe" condone or support such "values"?

No doubt there are crooks and thieves in all demographics, but many of them make some effort at least to anathematize or criminalize such behaviour, not reward the perpetrators.

Don't think you really answered my


in the Trump thread, but here's his words in context-

Unknown: "She used to be great, she's still very beautiful."

Trump: "I moved on her actually. You know she was down on Palm Beach. I moved on her, and I failed. I'll admit it. I did try and fuck her, she was married."

Unknown: "That's huge news there."

Trump: "No, no, Nancy. No this was [inaudible] and I moved on her very heavily in fact I took her out furniture shopping. She wanted to get some furniture. I said I'll show you where they have some nice furniture. I moved on her like a bitch. I couldn't get there and she was married. Then all-of-a-sudden I see her, she's now got the big phony tits and everything. She's totally changed her look."

Bush:in the Trump thread, but here's his words in context-

Unknown: "She used to be great, she's still very beautiful."

Trump: "I moved on her actually. You know she was down on Palm Beach. I moved on her, and I failed. I'll admit it. I did try and fuck her, she was married."

Unknown: "That's huge news there."

Trump: "No, no, Nancy. No this was [inaudible] and I moved on her very heavily in fact I took her out furniture shopping. She wanted to get some furniture. I said I'll show you where they have some nice furniture. I moved on her like a bitch. I couldn't get there and she was married. Then all-of-a-sudden I see her, she's now got the big phony tits and everything. She's totally changed her look."

Bush:


FUCKING BABOONS.

CommanderTuvok wrote: ↑
I'm sure you Pitters will be shocked to learn that Talcolm X was one all over social media raising funds, after he jumped (again!) to the wrong conclusion and blamed a "white man" for the murder of that 7-year old girl.

These freaks are just as guilty of what they accuse the "alt-right" of doing. Whenever there is a murder, they jump to some conclusion that fits their agenda, and then go quiet when they are exposed as lying about it.

PS. Hilarious about Ofie and Peez. DIVIDE AND FUCKING CONQUER THE SHIT OUT OF THESE FUCKING BABOONS.

Shaun King is taking credit for passing on the correct tip to the police, in contrast to his earlier insistence that it was a white racist hate crime. He's alsohe not act like that when he actually meets the woman he is joking about even when she makes it clear she is prepared to accept quite a bit of sexual forwardness from Billy Bush?

<snip>
Do enjoy the whole thing. The idea that somehow the quote was taken out of context is popular among certain folks, but there really isn't any way to make it look good when you have the whole transcript in front of you. Unless you happen to enjoy whataboutism or substitute expediency for morality.

<snip>
This is like the "confession" in Presumed Innocent.

Are you and the Captain trying to see how many times you can repeat the same boiler-plate, adding dozens of "paragraphs" every time, before the system breaks?

Acceptable standards hereabouts, even if not everyone subscribes to


squamous cell cancers, 20 adenocarcinomas). In paraffin sections of the studied tumours, immunocytochemical reactions were performed, using mouse monoclonal anti-MT and anti-Ki-67 antibodies. The expressions of MT and Ki-67 were demonstrated in all the studied tumours. An analysis of correlation between the expression of MT, Ki-67 antigen and G grade demonstrated a strong positive relation between the latter two parameters (r=0.70; p<0.05). Less pronounced positive correlations were disclosed between MT expression and G grade (r=0.44; p<0.05) and between MT expression and the expression of Ki-67 antigen (r=0.41; p<0.05). In addition, in 15 cases of examined tumours, survival analysis was performed, which disclosed a shorter survival in patients with high MT expression. The obtained results confirmed the relationship between MT expression and Ki-67 antigen expression, indicating an involvement ofcase

       law, appellate courts may revise sentences after due consideration of the trial

       court’s decision, if the sentence is found to be inappropriate in light of the

       nature of the offense and the character of the offender. Cardwell v. State, 895

       Court of Appeals of Indiana | Memorandum Decision 79A02-1409-CR-667 | July 24, 2015   Page 4 of 7
       N.E.2d 1219, 1222-25 (Ind. 2008); Serino v. State, 798 N.E.2d 852, 856-57 (Ind.

       2003). The principal role of such review is to attempt to leaven the outliers.


// RUN: %clang_cc1  -debug-info-kind=limited -S -o %t %s
// RUN: not grep "001-[F bar" %t
// Linkage name should not use 001 prefix in debug info.

@interface F
-(int) bar;
@end

@implementation F
-(int) bar {
	return 42;
}
@end

extern int f(F *fn) {
	return [fn bar];
}

Q:

Singapore Airlines seat selection after online booking

I read some similar questions (e.g. this), but they concern European airlines that have to act under European laws, Singapore Airlines probably doesn't.
I booked a flight from FRA to SIN (and further on, 4 legs in total back and forth). For all flights but the one mentioned, there were enough seats to select online one that wouldn't cost me any extra money. For the FRA - SIN flight there were only seats left they would charge me extra.
Obviously I don't have to select a seat now before checking in prior to my flight.
a) Will I have to when checking in online?
b) If not, will I probably just get any seat that is unoccupied at the time of checking in at the counter?
Thanks!

A:

Singapore


and Luapula River, Kundabwika Waterfalls, Chilongo Waterfalls located  from Kawambwa boma are the major water falls in the province. Other major picnic areas in the Province are the Samfya Beach in Lake Bangweulu, the shores of Lake Mweru in Chienge District, and the Nchelemge Beach in Lake Mweru. Lusenga Plain National Park and Bangweulu Wetlands are the major wildlife areas in the province. Lake Mweru, Luapula River, Lake Bangweulu and its wetlands have exotic bird life, aquatic animals and fish.

Mutukumbo festival is the major festival celebrated in the province in Luapala Valley. It is held annually during July and attracts around 20,000 people, including the President of Zambia. The event involves enacting the migration of Luba Lunda and conquest of the valley by the chiefs of thewe utilized Gene Set Enrichment Analysis (GSEA) to determine whether a previously defined set of angiogenesis-associated genes showed statistically significant, concordant differences between the high-CTHRC1 group and the low-CTHRC1 group (ES = 0.556, NES = 1.442; *P *\< 0.001; Fig. [3](#Fig3){ref-type="fig"}b) in our microarray data. The results showed that angiogenesis-associated genes were enriched in the high-CTHRC1 group, which indicated that the expression of genes related to the promotion of angiogenesis was more activated in LUAD patients with high CTHRC1 levels than in LUAD patients with low CTHRC1 levels. Additionally, in the TCGA cohort, we observed that the mRNA expression of CTHRC1 was positively associated with the expression of VEGF (*r *= 0.137, *P *= 0.002; Fig. [3](#Fig3){ref-type="fig"}c), and GSEA also showed that CTHRC1 expression remained linked with angiogenesis (ES = 0.635, NES = 1.838; *P *\< 0.001; Fig. [3](#Fig3){ref-type="fig"}d). As shown in Fig. [3](#Fig3){ref-type="fig"}e, CTHRC1 and VEGFA was


bevacizumab (a humanized anti-vascular endothelial growth factor (anti-VEGF) monoclonal antibody) in combination with chemotherapy appeared to be effective and safe in patients with unresectable stage III LUAD. However, few investigations have studied the clinical applications of anti-VEGF therapy in large LUAD samples, probably because of the difficulty in the early diagnosis of LUAD. Thus, an effective predictive panel is urgently needed to increase the accuracy of early diagnosis and to promote the development of anti-VEGF therapy in LUAD.

CTHRC1 can be upregulated to promote tumor growth (in vitro and in vivo) by several mechanisms, such as the demethylation of the CTHRC1 promoter and canonical WNT signaling, and can be inhibited by a group of microRNAs to reduce cancer growth (in vitro and in vivo) in many tumors, such asUK minimum wage

'Living wage' would give UK economy a much-needed boost

Raising the minimum wage up to the ‘living wage’ could provide the UK economy and the Government's coffers with a much-needed boost says Professor Kim Hoque.The minimum wage increased by 12p to £6.31 per hour recently, a rise of 1.9 per cent, though inflation is currently running at 2.7 per cent. Campaigners, such as the Living Wage Foundation, have called for the minimum wage to be raised to £7.45 per hour and £8.55 in London.

Professor Hoque, who has consulted for the Chartered Institute of Personnel and Development, Shell UK, NHS Scotland and the UK Commission for Employment and Skills, believes such a significant rise would not only help the country’s lowest earners but give the economy a vital


those city residents hit with new taxes see a direct and tangible benefit for those higher tax bill that they will get. It could be in form of a direct payment to those cities for the maintenance and operations of their own parks, or it could include some assistance for maintenance and upkeep. Such an agreement would be fair and it would reflect well on Greenville County Council.

Second, the county should avoid setting the new millage so low as to underfund the operation and maintenance of these popular parks that are showing wear and tear. A county aversion to paying for the upkeep, after all, has created this problem. When new parks were being discussed in 2002, this editorial page warned that County Council did not have a  """
    This function will convert siemens 4d series to a nifti
    Some inspiration on which fields can be used was taken from
    http://slicer.org/doc/html/DICOMDiffusionVolumePlugin_8py_source.html
    """
    # Get the sorted mosaics
    all_dicoms = [i for sl in grouped_dicoms for i in sl]  # combine into 1 list for validating
    common.validate_orientation(all_dicoms)

    # Create mosaic block
    logger.info('Creating data block')
    full_block = _classic_get_full_block(grouped_dicoms)

    logger.info('Creating affine')
    # Create the nifti header info
    affine, slice_increment = common.create_affine(grouped_dicoms[0])

    logger.info('Creating nifti')
    # Convert to nifti
    nii_image


en bvec files')
            bval_file = '%s/%s.bval' % (base_path, base_name)
            bvec_file = '%s/%s.bvec' % (base_path, base_name)

        bval = _create_bvals(grouped_dicoms, bval_file)
        bvec = _create_bvecs(grouped_dicoms, bvec_file)

        return {'NII_FILE': output_file,
                'BVAL_FILE': bval_file,
                'BVEC_FILE': bvec_file,
                'NII': nii_image,
        The slow shutter speed is less a problem because the image stabilizer (Steadyshot) helps, at least for static scenes like landscapes. Although it is not completely reliable at these shutter speeds, I got acceptable images even at full 465 mm zoom in Nightshot mode.

This is a huge improvement compared to older Cybershot models, where anything above 50 mm equivalent or so in Nightshot mode requires a tripod. Of course a modded DSC-F717 is better, but that is not an off-the-shelf option. The other limitation is that - like previous Nightshot incarnations - in normal daylight, ND filters are required to prevent overexposure at 1/30 sec. (check Jerry's excellent article about Nightshot mode in the Beginner’s Section).

The Nightshot Switch There is a way to bypass the Nightshot limitations, by


the zoom or not, i cant get to focus on the fly coz its to far zoomed in , please help thanks

Things to do on the IR Buzz

Infrared For Beginners Series -- Currently in 9 Parts, describing the basics of Infrared and delving into cameras, why you might want to modify them, and how to use them. Start the Series Here!

Featured IR Photographers Showcase -- IR shooters display their work and IR Photography skills. Check out the artists from around the world. There is no better way to improve your own skills than to look for inspiration from others! Currently Featuring Michael Keesling

Revisit Featured Artists -- So, you've been here before, and you've faithfully followed and visited each new Showcased Artist ,,, well, I have to tell youreported series of thiazolo\[5,4-*d*\]pirimidines, designed as potential agonists of the A~2A~AR as bioisosteres of the purine ring on the basis of molecular docking and superposition with the classical agonists (e.g., adenosine, NECA) \[[@B28-molecules-22-01945]\]. The molecules in this series that contain a 7-prolinol substitution were characterized as a new class of non-nucleoside A~2A~AR partial agonists, confirming the hypothesis of the design where the 2-hydroxymethylene moiety of the prolinol would mimic the interactions of the 2′/3′ hydroxyl groups of the ribose of agonists, observed in all agonist bound A~2A~AR crystal structures. To understand the molecular determinants of the functional behavior of these molecules, we designed a thermodynamic cycle where the partial agonist ligand **10n** (containing prolinol, relative efficacy as compared to NECA \> 50%) was transformed in its antagonist analog


easily assembled via the Biginelli multicomponent reaction, an advantage when it comes to develop series of compounds and evaluate their SAR \[[@B29-molecules-22-01945]\]. The promising affinity of some compounds in the initial series, measured as a racemic mixture, was explored by means of molecular docking on our A~2B~AR homology model. The model revealed an enantiospecific binding orientation, suggesting the potential stereoselectivity of this scaffold and identifying the potentially active isomer ([Figure 4](#molecules-22-01945-f004){ref-type="fig"}). These promising results led to a further exploration of non-planar derived scaffolds, by structural diversification at face 2 of the diazinone scaffold. Three series of analogues were developed, namely 3-deaza\[pyridin-2(1*H*)-ones\] and bicyclic and tricyclic derivatives fused at positions 2,3 or 5,6 of the heterocyclic framework, identifying selective and potent A~2B~AR ligands ([Figure 1](#molecules-22-01945-f001){ref-type="fig"}) where the hypothesis ofthe stereoselectivity was maintained \[[@B32-molecules-22-01945]\].

In a later modification of the original scaffold, we created a series of 2-cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylates \[[@B31-molecules-22-01945]\]. This time the two enantiomers of the most attractive ligand (**16b**) were separated by chiral HPLC and their absolute configurations established by circular dichroism ([Figure 4](#molecules-22-01945-f004){ref-type="fig"}). The biological evaluation of the two enantiomers demonstrated that the affinity is exclusively due to the *(S)*-**16b** enantiomer, validating the prediction from our molecular modeling studies.

The docking studies of these series of non-planar scaffolds were complemented by MD simulations, which allowed characterizing the role of water molecules in ligand binding. In a first stage, the selected complex of A~2B~AR was equilibrated with our PyMemDyn protocol, as implemented in the GPCR-ModSim web server \[[@B44-molecules-22-01945],[@B45-molecules-22-01945]\] (see Methods). From this analysis, we identified a water molecule


\[[@B44-molecules-22-01945]\]); (iii) Energy minimization was performed using Schrödinger suite, in the case of homology models \[[@B54-molecules-22-01945]\].

4.2. Ligand Docking {#sec4dot2-molecules-22-01945}
-------------------

The different docking explorations on each AR here reported followed the same scheme: Ligands were build and optimized in the 3D using the Maestro graphical interface and the LigPrep utility from the Schrödinger suite \[[@B55-molecules-22-01945]\]. For the series of enantiospecific ligands, this included considering *R* and the *S* stereoisomer and possible tautomers in parallel dockings. Each ligand was docked 20 times with default (high accuracy) genetic algorithm (GA) search parameters, using the scoring function Chemscore as implemented in GOLD \[[@B56-molecules-22-01945]\] and allowing full flexibility for the ligand, including flipping of amide bonds. The search sphere was centered on the side chain (CD1) of Ile^7.39^ and expanded with a radius of15 Å, thus ensuring a generous enough search space comprising the orthosteric binding site experimentally determined for adenosine receptors. In the A~2B~AR, two water molecules were considered in the binding cavity, as explored here by MD simulations (see below). In this case, we used the option *toggle trans_spin* 2 in GOLD, meaning that the water contribution is only included if it produces an increase in the predicted scoring and hydrogen bond network is optimized, combined with the *assemble structure* option in GOLD to account for the two rotamers of Asn^6.55^. The criterion for the selection of docking poses was based on a combination of the Chemscore ranking and the population (convergence) of the solutions according to a clustering criterion of 1 Å.

4.3. Membrane Insertion, Molecular Dynamics Equilibration and


other there is a collection of liberals, leftists and Christians who claim the draft charter restricts freedoms and gives Islamists vast influence over the running of the country. As night fell in Cairo on Tuesday, rival protests swelled as thousands of people from both camps gathered in the capital, many of them arriving by bus from other regions.

In the Nasr City district, a Muslim Brotherhood stronghold, tens of thousands of the president’s backers rallied in front of a neighborhood mosque. “You can expect a lively scene here tonight,” FRANCE 24’s Chris Moore reported from the scene. “But supporters here have told us that they have no intention of going to the presidential palace, avoiding a repeat of those violent scenes that we saw last week”.

Just a few kilometers       theRightSide.appendChild(leftSideImages);
            }

            generateFaces()

            var theBody = document.getElementsByTagName("body")[0];

            theBody.onclick = function gameOver() {
                alert("Game Over!");

                theBody.onclick = null;
                theLeftSide.lastChild.onclick = null;
            };


(when the GC cleans). The theLeftSide.lastChild doesn't creates a reference to whatever last child element of theLeftSide is. It creates a reference to the current last child.
You must change the place you add the event handler to inside your generateFaces function, so everytime you change the theLeftSide children, you get again the last child, and add the event.
Take a look at the example below:

<!DOCTYPE html>
<html>

<head>
  <title>Matching Game</title>
  <style>
    img {
      position: absolute;
    }
    div {
      position: absolute;
      width: 500px;
      height: 500px;
    }
    #rightSide {
      left: 500px;
January 2, 2011, his last day in office as Governor of California, Arnold
Schwarzenegger exercised his executive clemency power (Cal. Const., art. V, § 8, subd.
(a); Pen. Code, § 4800; unless stated otherwise, statutory section references that follow
are to the Penal Code) by commuting (reducing) the prison sentence of Esteban Nunez
from 16 years to seven years.
       The commutation came as a complete surprise to the crime victims and the
prosecuting district attorney.
       This litigation seeks to invalidate the commutation, arguing crime victims and
district attorneys must receive notice and opportunity to be heard before a grant of
executive clemency, pursuant to the Victims’ Bill of Rights Act of 2008, also known as
Marsy’s Law, adopted by voter initiative Proposition 9 in


to 16
years in prison. The executive order said the evidence was that Jett started the
confrontation. The executive order stated, “Nunez applied for a commutation of his
sentence on the ground that his sentence is disproportionate in comparison to Jett’s
sentence.” The executive order stated, “Considering Nunez’s limited role in the killing
and his clean prior criminal record, I believe his sentence is disproportionate in
comparison to Jett’s.”

                                              6
        The victims and the district attorney learned about the commutation after itplaintiffs filed suit (the Dumanis lawsuit) in San Diego for
declaratory and injunctive relief and a writ of mandate, seeking to invalidate the
commutation, enjoin its implementation, and mandate calculation of Nunez’s term
according to the original sentence.
       The two lawsuits were coordinated and consolidated in Sacramento County.
       Defendants moved for judgment on the pleadings on the grounds that Marsy’s
Law does not apply to the Governor’s exercise of constitutional authority to grant
executive clemency, and plaintiffs never requested notice. Although plaintiffs’
complaints cited executive clemency statutes -- e.g., applicant for pardon must notify
district attorney (§ 4804), Governor must report commutations to the Legislature (§ 4807)
and maintain a register of clemency applications (Gov. Code, § 12030) -- plaintiffs told
the judge at the


may consider ballot
summaries and arguments in determining the voters’ intent and understanding of a ballot
measure. [Citation.]” (People v. Superior Court (Pearson) (2010) 48 Cal.4th 564, 571,
citing Professional Engineers, supra, 40 Cal.4th 1016 [voter initiative, expressly
removing constitutional restriction on government’s ability to contract with private firms
for architectural and engineering services on public works projects, impliedly repealed
preexisting statutes regulating private contracts for architectural and engineering
services].) Our job is to ascertain and declare what is in terms or in substance contained
in the provision, not to insert what has been omitted or omit what has been inserted.
(Code Civ. Proc., § 1858.) We adopt a construction “that will effectuate the voters’
intent, giv[ing] meaning to each word and phrase, and avoid absurd results. [Citations.]”
(People v. Stringham (1988) 206 Cal.App.3d 184, 196-197 (Stringham) [construing 1982
Victims’(2012) 209 Cal.App.4th 1182, 1192.)
       There is a presumption, though not conclusive, that voters are aware of existing
laws at the time a voter initiative is adopted. (Cervantes, supra, 225 Cal.App.4th at
p. 1015; but see, Brosnahan v. Brown (1982) 32 Cal.3d 236, 257 [it would be unrealistic
to require proponents of Proposition 8, 1982 Victims’ Rights Act, to anticipate and
specify in advance every change in existing statutory provisions which could be expected
to result from the adoption of that measure], cited in McLaughlin v. State Bd. of
Education (1999) 75 Cal.App.4th 196, 214 [qualitative and quantitative differences exist
between the state of knowledge of informed voters and that of elected members of the
Legislature].)


end. [¶] . . . [¶] . . . To accomplish the goals it is
necessary that the laws of California relating to the criminal justice process be amended
in order to protect the legitimate rights of victims of crime.” (Cal. Const., art. I, § 28,
subd. (a)(5)-(6), (8).)
       Marsy’s Law states: “In order to preserve and protect a victim’s rights to justice
and due process, a victim shall be entitled to the following rights: [¶] . . . [¶] (7) To
reasonable notice of all public proceedings, including delinquency proceedings, upon
request, at which the defendant and the prosecutor are entitled to be present and of all

                    Code section 679.026, which requires law
enforcement agencies and prosecutors to give each crime victim a list of “Marsy Rights.”
       Marsy’s Law nowhere mentions executive clemency and did not amend or add to
the executive clemency statutes (§§ 4800-4813), discussed post. Marsy’s Law mentions
only “parole” and “other” post-conviction proceedings or decisions that are part of the
“criminal justice system.”

       B.      Executive Clemency

       California Constitution, article V, section 8, subdivision (a), provides: “Subject to
application procedures provided by statute [§§ 4800-4813], the Governor, on conditions
the Governor deems proper, may grant a reprieve, pardon, and commutation, after
sentence, except in case of impeachment. The Governor shall report to the Legislature
each reprieve, pardon,


hearing constitutes a “ ‘post-conviction release proceeding’ ”
under the provision of Marsy’s Law regarding victims’ rights with regard to “ ‘parole or
other post-conviction release proceedings.’ ” (Kaulick, supra, 215 Cal.App.4th at
p. 1300.) Kaulick noted the next provision of Marsy’s Law gave victims the right to be
heard at any proceedings involving postconviction release decisions (Cal. Const., art. I,
§ 28, subd. (b)(8)). Kaulick said: “While it could conceivably be argued that the victim’s
right to be heard applies only to the resentencing hearing . . . and not the dangerousness
hearing . . . , we reject that view. Marsy’s Law already provides that victims have the
right to be heard at any proceeding involving ‘sentencing.’ [Citation.] The fact that the
[Three Strikes Reform] Act specifically classifies a ‘resentencing hearing ordered under
this act’ asa conditional pardon, to the extent that parole or conditional pardon are
only effectuated when such terms or conditions are accepted, does not relate at all to the
question of who possesses the distinct powers to parole and to conditionally pardon; nor
does the analogy . . . logically justify an inference that the power to pardon conditionally
ipso facto includes powers related to parole, or the converse.” (Ibid.) Fain went on to
say, “Although they may be similar in certain very limited respects--such as, for example,
that both may effectuate release from in-prison custody--a pardon is nonetheless
fundamentally distinct from parole, as are the powers to pardon and parole.” (Id. at
pp. 548-549 [listing differences].) Fain held the governor was without authority to
rescind the parole release date of a prisoner still in physical custody after


               30
to the Governor, as it did in connection with the power to revoke . . . . The fact that the
Legislature has not indicated the procedures to be followed by the Governor when
rescinding a parole release date further reinforces the conclusion that Legislature never
intended to authorize the Governor to rescind a parole release date.” (Fain, supra,
145 Cal.App.3d at p. 552.) In our case, if the electorate had intended victims to have the
right to notice and opportunity to be heard regarding executive clemency, the electorate
presumably would have prescribed in the clemency statutes provisions similar to those
the electorate expressly prescribed in the parole statutes.
       We disregard amici’s suggestion that      RAYE              , P. J.

                                             1
MURRAY, J. Concurring.

         I concur with the majority opinion and the concurring opinion of Administrative
Presiding Justice Raye. I write separately to note the following.
         Marsy’s Law provides that victims have the right “[t]o reasonable notice of and to
reasonably confer with the prosecuting agency, upon request,


the relevant project data. This would set out the ontology and metadata structure to enable the semantic indexing and retrieval of all types of data objects that could be sourced from a variety of sources such as individual project websites, project progress reviews and RIS3 innovation maps.

The metadata descriptors will provide data on all aspects of the project such as the Call, the Title, Contract Reference Number, Precursor Projects, Objectives, budget, matched funding, sponsors etc.

Initial analysis of the exact form of the data types to be supported and access routes/modes required will determine the detail structure of the data repository and user access interfaces that would prove appropriate for the ODP.

The stakeholders to interact with the database. This could be via a website or via a web service.action to learn the details of the attacks or take the lead in HCDE's response to the attacks. , , Further, Mr. Smith failed to make a sincere effort to contact any of the parents of the victims or other players on the trip. He also failed to create and foster an open line of communication with the family of the hospitalized player."

The report found that freshmen on the OHS varsity basketball team were subjected to repeated assaults under the guise of "hazing." It says several parents complained in October 2015 about the hazing, but nothing was done.

It says the "pervasive predatory attitude among athletes at OHS still exists." One of the victims of the January assaults, now a sophomore at a private school, recently called his mother


for granted. I wonder if you knew that someday I would find this spot, and come to visit you.

I am also currently working on a separate family tree trying to link my Great Great Grandfather Silas Josiah Lee to the famous Lee Family of Virginia. The Lee family of Virginia are related to George Washington, Robert E. Lee, Benijamin Harrison, Queen Elizabeth and their family lines. You may view this tree by clicking on family trees then click on the drop down box in the top right hand corner of the family tree and choose "Lee Family of Virginia". My Great Great Grandfather was born in Prince William County, Virginia. At one time the famous Lee family owned most of this area. I am about 90 percent sure1957, there was one episode overlooked in the brilliant celebrations; she was given an oil painting--no more than a copy, of a copy, of a portrait by Sir Godfrey Kneller. But it was of her American ancestor, Augustine Warner II, and it adds a surprising face to the immense collection of portraits of the Queen's forbears whose roots were otherwise still in Britain or Europe.

Mr. Anthony Wagner, Richmond Herald, was the first to trace this remarkable link with colonial Virginia, that relates Queen Elizabeth, through a Bowes-Lyon marriage, back to both George Washington and General Robert E. Lee. Augustine Warner I, born in England or Wales, in 1611, and who emigrated to Virginia when he was 39, was the ancestor of all three of them, through the marriages


have been his real income". But he remained in England and when his first wife died, he was married again, to another Virginian--Elizabeth Jennings, said to be distantly related to Sarah Jennings, Duchess of Marlborough. They produced a second family, including one remarkable son--the eighteenth of the brood of nineteen. He was Beilby Porteus, the scholar and poet who became Bishop of Leicester and then, in 1787, Bishop of London. The vigorous blood enlivened by the generations in Virginia had not become pale: Beilby Porteus was a belligerent leader in the ecclesiastical changes of his time; he was an ardent evangelist, a supporter of Sunday schools, and was strong-willed enough to turn against the source of his family fortunes in his fight to abolish slavery.

The Bowes-Lyon Family

The importantvegetation of the years.

The Center Christian Church is at some distance from this cemetery. A deed to this plot of land was made to this church and they are still the owners of it. The Grant County Deed Book, P pp. 254 reads as follows:

"that James Scott and his wife Annis Scott of Grant County Indiana in consideration of the Christian love & feelings toward the human family generally, have granted, bargained, donated and set apart for public use as a burying ground to inter any and every person that has not forfeited the laws of their God and Country and the further consideration of one dollar to us paid by Dugan Wall, Elwood Arnett, Marmaduke Mendenhall and John Harrold trustees of the Christian Church - Deer Creek,


school established at the place of worship. Rev. F. M. Collins is pastor or evangelist; William H. Ayers and William I. Millner, Elders; John Herrald, Cyrus W. Gibson, Jasper Wilson and William Jones, Deacons." This is the same Center Christian Church in existance today. (2000) Actually I believe the first one was called Christian Church (New Lights) of Deer Creek, not Center as was written by the DAR above. Investigation to find the name of the McCombs whose stone is in this cemetery brought this information from Miss Cornelia McCombs of Fairmount who is his grand daughter, "my grandfather is buried in the Scott Cemetery. His given name was John Young McCombs. I am not sure that grandfather was in the War of 1812, but think he wastime probably, around Memorial Day, someone had put a number of flags up in memoriam to dead soldiers. This is usually done by the American Legion in honor of soldiers who fought in the various wars.

This is a very small plot. But you can see a number of unmarked graves. I am guessing there are probably at least twice as many graves here, than shows in the readings. The earliest grave I found is Daniel Felton son of S. & M. Felton who died Nov. 8, 1856. The one listed by the DAR turned out to be in error. They had 1854 but it was 1874. I only found 2 other graves that were not previously listed. I am sorry to say there were three graves I did


    {
            return BuildInternal(expression.Body);
        }

        public bool Clear(TomlObject target)
        {
            var tgt = this.parent == null ? target : this.parent.TryGet(target);
            if (tgt != null)
            {
                return this.segment.Clear(tgt);
            }

      him to the ground on Oct. 8, 2015. Valles was later ... more

A June 5, 2015, video showing McKinney Officer David Eric Casebolt throwing a black girl in a bikini to the ground raised questions about racial bias and aggressive policing. The video also shows the officer ... more

Amarillo Police Cpl. Vern Wilson was suspected of using excessive force after he asked 14-year-old Jacob Herrera to remove a rosary he wore at a football game on Oct. 29, 2014. The rosary was allegedly associated with gang apparel.

Amarillo Police Cpl. Vern Wilson was suspected of using excessive force after he asked 14-year-old Jacob Herrera to remove a rosary he wore at a football game on Oct. 29, 2014. The rosary was allegedly ... more

Four Houston police officers received criticism


over the 2010 beating of 15-year-old burglary suspect Chad Holley, who was running from officers when he tripped and surrendered. The video shows officers kick and beat Holley.

Four Houston police officers received criticism over the 2010 beating of 15-year-old burglary suspect Chad Holley, who was running from officers when he tripped and surrendered. The video shows officers kick ... more

Four Houston police officers received criticism over the 2010... Photo-7940119.127727 - San Antonio Express-News

Image 7 of 8

Dash cam video captured Paris, Texas officer Jeremy Massey slamming handcuffed teenager Cornelius Gill onto the hood of a police cruiser in November 2009. Massey was suspended for two days without pay, and Gill was jailed for disorderly conduct.

Dash cam video captured Paris, Texas officer Jeremy Massey slamming handcuffed teenager Cornelius Gill ontoclose correlation with measured changes in sodium balance in glucocorticoid treated rats. In addition arterial pressure sensitivity to angiotensin II and te response to an angiotensin antagonist (1-Sar 8-ala- angiotensin II) are to be carried out. The results of these studies may bear on the pathogenesis of hypertension in Cushing's Syndrome and that associated with glucocorticoid therapy - especially in the area of the treatment of chronic glomeruler diseases and of renal transplant patients.


losses: {SUPPORTED_LOSSES}")

class SkipLastTargetChannelWrapper(nn.Module):
    """
    Loss wrapper which removes additional target channel
    """

    def __init__(self, loss, squeeze_channel=False):
        super(SkipLastTargetChannelWrapper, self).__init__()
        self.loss = loss
        self.squeeze_channel = squeeze_channel

    def forward(self, input, target):
        assert target.size(1) > 1, 'Target tensor has a singleton channel dimension, cannot remove channel'

        # skips last target channel if needed
        target = target[:, :-1, ...]

        if self.squeeze_channel:
        Then Upload A Jpg Or Gif With Outstanding Invoices Official Weworked Blog And Charming Copy Of An Invoice Template As Well As Filemaker Invoice Template Additionally Definition Of Purchase Invoice With Msrp Price Vs Invoice Price Also Peachtree Invoice In Addition Definition Of A Invoice Via Blogweworkedcom › Gallery

Picnictoimpeachus Outstanding Invoices Official Weworked Blog With Charming Your Logo Will Appear On All Your Invoices Now Go Make It Happen Click Settings Then Edit For The Company Section You Can Then Upload A Jpg Or Gif And Surprising Msrp Price Vs Invoice Price Also Peachtree Invoice In Addition Definition Of A Invoice From Blogweworkedcom › Photograph

Picnictoimpeachus Stunning Download Contractor Invoice Template With Exquisite Invoice Template Contractor Printable Invoice Template And Nice Invoice Factoring Definition As Well As What Is


and distends time itself... Reissman's life floats in space like the suspended matter in a lava lamp. The cumulative effect carries an impact—simultaneously visceral and intellectual—that is unique to comics."

Mad
Krigstein also did humor, such as "From Eternity Back to Here" in Mad #12, "Bringing Back Father" in Mad #17 and "Crash McCool" in Mad #26.

In the early 1960s, Krigstein left comics in order to draw and paint illustrations for magazines, book jackets (notably, the first edition of Richard Condon's The Manchurian Candidate) and record albums, eventually turning away from commercial assignments in order to focus on fine art. In 1962, he took a position at the High School of Art and Design in Manhattan, where he taught for 20 years.

As Krigstein told a 1962 interviewer, "It's what happenscauses of inflamed papilla including acid or gastroesophageal reflux, allergies and food sensitivities, mouth burns, bacterial or viral infections possibly due to the lack of oral hygiene, oral cancer, smoking, stress, and iron and vitamin B deficiencies.\[[@ref15][@ref16]\]

These dental and oral problems may be related to the chemical quality of the water consumed by humans.\[[@ref17]\] Water is one of the resources affected by human actions and environmental pollution that leave hazardous microorganisms and chemical elements in the body.\[[@ref18]\] For example, the exposure to high amounts of iron or iodine can cause substantial black tooth. On the other hand, exposure to sulfide, silver nitrate, or manganese may be associated with gray-yellow or brown-black stains, copper or nickel can cause green stains, and cadmium can produce yellow-brown pigmentations.\[[@ref17][@ref19]\]

The environmental, demographic, and


in to "clean up" the base following the disaster. It is their job to execute anyone with knowledge of the research project that went awry. The more you know about the project, the more they want to kill you. They especially hate you, Gordon Freeman, personally - because you have cut down quite a few of their buddies.[7]

Following the catastrophic Resonance Cascade at the Black Mesa Research Facility, bizarre aliens from Xen teleport into the complex and begin attacking personnel. The Hazardous Environment Combat Unit is dispatched to the facility to fight the aliens and regain control of Black Mesa. Unknown to the surviving personnel at Black Mesa, though, the Marines have also been ordered to eliminate Black Mesa's civilian personnel to ensure that the incident is coveredscene that mirrors apprehension.

If a soldier is critically wounded, the grunt will yell "MEDIC!" and they will limp; this also applies in Half-Life, even though there is no Medic.

Spawned grunts with the console command "give_monster_human_grunt" will be hostile. The reason for this is because instead of modifying the vanilla Half-Life grunts to be friendly to the player, Gearbox made a separate NPC. The console command for spawning friendly grunts is "give_monster_human_grunt_ally."

Friendly grunts spawned from the console will always be the generic Gasmask soldier with no weapon.

With the exception of scripted sequences, the grunts and Black Ops seem to be the only ones to reload their weapons.

If a soldier is killed by the player all soldiers on sight will treat him as a traitor and will start shooting at


Pope talks of suffering during Good Friday TV show

Friday

VATICAN CITY — Pope Benedict XVI consoled a 7-year-old Japanese girl, reassured a mother about her ailing son’s soul and advised a Muslim woman that dialogue was the way to peace in Ivory Coast.

VATICAN CITY — Pope Benedict XVI consoled a 7-year-old Japanese girl, reassured a mother about her ailing son’s soul and advised a Muslim woman that dialogue was the way to peace in Ivory Coast.In a push to engage the world online, the pontiff fielded their questions during an unusual Good Friday appearance on Italian TV. It was hardly a casual or spontaneous chat: Seven questions were selected from thousands that poured in via RAI television’s website, and Benedict recorded his answers last week.He seemed a bit stiff,Primary and secondary cell death in human melanoma xenografts following hyperthermic treatment.
The response to hyperthermic treatment (42.5 degrees C for 60 min) of 5 human malignant melanomas grown in athymic mice (BALB/c/nu/nu/BOM) was studied. Local hyperthermia was given by immersing the tumor-bearing leg of the mice into a thermostatically regulated water bath. Growth delay studies indicated that the melanomas were different in heat responsiveness. The differences were confirmed by measuring the fraction of clonogenic cells in the melanomas as a function of time after treatment. The latter experiment showed that some tumor cells were inactivated during the treatment, while others lost clonogenicity first after completion of the treatment. Examinations of histological sections from tumors fixed 1 h after treatment revealed considerable vascular occlusion in all 5 melanomas. This


indicates that the observed delayed cell death might be due to a number of factors, e.g., insufficient supply of oxygen and nutrients, increased tumor acidity, and accumulation of toxic metabolic products. It is concluded that at least two different mechanisms govern the overall heat response of the melanoma xenografts: the primary cell death, induced during treatment, is due to direct cytotoxic effects of the heat; the secondary cell death, induced after completion of treatment, is due to heat-induced vascular damage. The differences among the melanomas in overall heat responsiveness appeared mainly to be a consequence of differences in secondary cell death. The secondary cell death was shown to be least pronounced for those melanomas in which most of the larger vessels were embedded in broad bands of connective"These tough new sanctions will make would-be enablers think twice and in turn reduce the number of schemes on the market."

Accountants and advisers who enable their clients to avoid tax will face tough penalties under new government proposals announced today.

Advisers who facilitate tax avoidance could face a fine of up to 100% of the tax underpaid.

In its consultation, the government said that although tax avoiders face "significant financial costs", those who advise them face "little risk".

The move is part of the government’s clamp down on corruption following the ‘Panama Papers’ scandal, which showed HSBC was 'routinely' helping wealthy UK customers to avoid paying taxes.

The leaked documents found that almost 7,000 Britons were hiding funds in offshore Swiss bank accounts and that HSBC helped clients to conceal bank accounts