that act, and thus becoming liable to pay the designated percentage of its gross earnings in lieu of taxes for the year 1889, that liability would not be discharged by the subsequent repeal of the gross-earnings act of 1889. If the company was released from the gross-earnings tax by the repeal of the act its property immediately became subject to assessment and taxation in the manner provided for the assessment and taxation of property of individuals in the territory, and it would not vitiate any such assessment made on the part of the counties that happened to be made prior to the repeal of the act of 1889. Such assessment would remain in full force and effect after the repeal of the act, and until satisfied.

11
It is nexttitle or ownership in the lands described and assessed. Nor do the averments of the bill negative the fact that the appellant was properly chargeable with taxes on the lands coming within the grant of July 2, 1864, and within the limits of the line of definite location of its road. Payment of the gross-earnings tax imposed by the act of 1889 would have discharged all claims for taxes upon the company's lands for that year, but no ground is shown by the bill for releasing the appellant from the payment of either the percentage tax on its gross earnings or from the payment of the assessments upon its lands made by the county auditors. By section 7 of the act of 1889, its failure to promptly and


person shall knowingly or wilfully swear falsely, concerning the matter aforesaid, every such person is declared to have committed perjury; and for the purpose of securing to the territory the payment of the aforesaid per centum it is hereby declared that the territory shall have a lien upon the railroad of said company, and upon all property, estate, or effects of said company whatsoever, personal, real, or mixed, and the lien hereby secured to the territory shall have and take precedence of all demands, decrees, and judgments against said company.
2. When Company shall Fail to Make Return.—If any such railroad company having accepted this act shall fail to make return of its gross earnings as aforesaid, or of any part thereof, at the time and in the mannerby law to be made by such company, and shall in all courts within this territory be evidence of the amount of such tax and penalty and of the other facts stated therein in pursuance of this act.
3. Neglect to Pay Taxes.—In case any railroad company which shall have accepted the provisions of this act shall fail or neglect to pay the amount reported at the time and in the manner hereinafter provided, for a period of thirty days after the same shall have become due by the terms thereof, in such case there shall be added to the amount of such tax ten per centum thereof as a penalty for such failure or neglect to pay.
4. Territorial Treasurer to Distrain.—At any time after the expiration of the


taxes due for the current year shall be paid to the territorial treasurer on or before the 15th day of August, 1889. Any railroad company that may be hereafter organized in this territory, or that shall hereafter become the owner of or engaged in operating any lines of railroad in this territory, may accept and become subject to the provisions of this act by filing a resolution of its board of directors in the manner as hereinbefore provided.
In case any such railroad company shall accept and become subject to the provisions of this act, it shall at the time of filing such acceptance render an account of gross earnings both territorial and interstate, in the manner as hereinbefore provided, and shall pay at the time of rendering such$1.425 million with the Bucs this season. As a vested veteran, he is entitled to file for termination pay, which would potentially pay him the remaining balance of his contract.

It is the latest in a series of run-ins with police for Stevens, who was sentenced to 30 days in jail in Arizona for extreme DUI in 2007 and has a history of alcohol-related offenses.

Given the quantity Stevens is accused of having and the proximity of the arrest to the team's hotel — Stevens and his teammates were due to check in within the hour, as they do every Saturday night before home games — the incident raises potentially uncomfortable questions for the Bucs.

Asked whether Stevens could have intended to share the drug with his teammates, Morris declined to


= -3*i - i + 20, 6 = 2*i. Let x(y) = y**3 + 4*y - 2*y**2 + k - 4*y**2 + 8*y**2. Give -4*t(d) + 3*x(d).
-5*d**3 - 2*d**2 + 2
Let j(y) = 442*y**2 - 52*y - 52. Let u(h) = -6 - 3*h + 0*h**2 - 6*h**2 + 3 + 32*h**2. Give -3*j(v) + 52*u(v).
26*v**2
Let c(o) = -7*o - 1. Let i(x) = -7*x + 0 - 1 - 3*x. Let g be (-32)/96 + (120/(-9))/(-4). Suppose -21 = 6*m - g*m. Calculate m*c(d) + 5*i(d).
-d + 2
Let q(j) = 456*j**2 + 22*j - 36. Let h(w) = -w**2 - 2*w + 18. Give -2*h(m) - q(m).
-454*m**2 - 18*m
Let o(s) = 209*s. Let n(g) = -214*g + 1. Give -2*n(h) - 3*o(h).
-199*h - 2
Let h(c) = -3*c+ 4. Let t(j) = 4*j - 11 + 7*j - 3*j. Let r be 5 - ((-24)/(-10))/((-24)/60). Give r*h(b) + 4*t(b).
-b
Let f(a) = 15*a**2 + 33*a. Let o(s) = -s**2 - 2*s. Let z be (-2)/(-3) - (-301)/21. Let w be (-23)/((-2415)/14) + 1483/z. Calculate w*o(n) + 6*f(n).
-9*n**2
Let g = -60 + 61. Let h(y) = -7. Let z(b) = 2. Let u(l) = g*h(l) + 4*z(l). Suppose 3*i = -25 + 22. Let m(v) = -2*v + 1. Determine i*u(q) + m(q).
-2*q
Suppose 16 = -4*k, 2*k = u - 2*k - 21. Let m be 2/(-3) + u/3. Suppose -33*b + 21*b = -21*b + 108. Let t(y) = -16*y. Let r(i) = i. What is b*r(a) + m*t(a)?
-4*a
Suppose -772*a = -756*a - 1056. Let z(y)


-1 + 3*a + 4 - 6. Let w = 131 - 134. Let n be w + (3 + -7 - -3) - -2. What is n*o(q) + 7*h(q)?
q - 1
Let s(x) = 22*x**3 + 2*x**2 - 108*x. Let l(f) = -2*f**3 - f. Give -9*l(y) - s(y).
-4*y**3 - 2*y**2 + 117*y
Let w(p) = 0 - p**2 + 6*p**2 + 4 - 4*p**3. Suppose -318 = 12*n - 8850. Suppose z + 706 = n. Let d(s) = 3*s**3 - 4*s**2 - 3. Calculate z*d(t) + 4*w(t).
-t**3 + 1
Let t(w) = -4*w - 14. Let s(n) = -n - 28. Let g(y) = -3*s(y) + 5*t(y). Let z(i) = -6*i + 5. Let v = 12 + -20. Determine v*z(b) + 3*g(b).
-3*b + 2
Let a(o) = -402*o**2Q:

How do I use "make" to build the mod_wsgi module package?

Once the package has been configured, it can be built by running: make

I ran the configure script and it said "process complete."
How do I perform this task in the terminal? I'm using a Mac. I'm not familiar with the command line.

A:

Be in the directory where you ran configure (it should contain a Makefile) and just type make and hit enter.


missed

• Indiana missed out on its first try for bowl eligibility with a 52-27 loss at Michigan State. The Hooisers will try again next week against Penn State in Bloomington, Ind.

• If only Northwestern could have taken Duke to overtime earlier this year. The Wildcats have won back-to-back Big Ten games in overtime after defeating Minnesota 49-48 in double overtime Saturday. C.J. Bacher has turned his season around by completing 79 of 106 passes for 990 yards, nine touchdowns and no interceptions in the last two weeks.

• The nation's worst defense managed to hold Louisiana-Monroe running back Calvin Dawson to fewer than 100 yards for the first time in 10 games. Dawson ran for only 65 yards in a 31-21 loss to North Texas for Todd Dodge's firstVittatoe, UTEP38 of 55, 409 yards, three touchdowns, interception in 45-42 loss to East Carolina in overtime on Saturday
Redshirt freshman has rarely been noticed but has become Mike Price's latest protégé.

Paul Smith, Tulsa34 of 39, 385 yards, three total touchdowns in 38-31 win over Marshall.
Smith has topped 300 passing yards in every game this year.

Rushing

Chad Hall, Air Force31 carries, 256 yards, four touchdowns in 45-21 win over Colorado State
Set school record for rushing yards.

James Starks, Buffalo35 carries, 244 yards, three touchdowns in 43-33 win over Toledo
Starks had the first 200-yard rushing day for Buffalo in 11 years.

Reggie Arnold, Arkansas State24 carries, 225 yards in 52-21 win over Louisiana-Lafayette
Part of a record setting day for Arkansas State, which had 681 yards of offense.


that high again until this month.

Although the GOP fared worse than Democrats as a party, the poll found that respondents had a stronger unfavorable opinion of Democratic leaders than Republican. House Minority Leader Nancy Pelosi (D-Calif.) received an unfavorable opinion of 51 percent, while Speaker John Boehner John Andrew BoehnerLongtime House parliamentarian to step down Five things we learned from this year's primaries Bad blood between Pelosi, Meadows complicates coronavirus talks MORE (R-Ohio) earned 40 percent. Senate leaders Harry Reid Harry Mason ReidGOP senators confident Trump pick to be confirmed by November Durbin: Democrats can 'slow' Supreme Court confirmation 'perhaps a matter of hours, maybe days at most' Supreme Court fight pushes Senate toward brink MORE (D-Nev.) and Mitch McConnell Addison (Mitch) Mitchell McConnellIn rare move, Schumer forceson •

One of the ways of starkly illustrating an aspect of the gender divide is DeBecker’s quote:

“At core, men are afraid women will laugh at them, while at core, women are afraid men will kill them.”

I think there’s a class and mothering parallel here:

Middle-class women are afraid of being mummy-tracked; working-class women are afraid of being fired.

Valuing and supporting mothering is an essential part of reproductive justice work. Reproductive choice doesn’t just involve the right to prevent or terminate a pregnancy. It involves the ability to continue a pregnancy, to birth in safety, and to mother without risking harassment or beating or child removal – or poverty. The “mommy track”, a lowering of the glass ceiling, isn’t the only risk mothers face.

An Ohio woman was fired for “taking


and a nick (gouge) occurring in a screw portion so that there is a concern and fear that quality may be decreased.
Thus, a primary aim of the present invention is to improve lubricity of a feed screw by a simple structure and also to offer a motor which can improve both the productivity and quality of a feed screw and to a method of manufacturing the same.
According to the invention, a motor comprises a motor case and a rotating shaft for the motor having a portion within the motor case and a portion extending outside of the motor case. A feed screw is formed on the extending portion of the rotating shaft. The feed screw threadedly engages with a moving body which moves back and forth along anarranged to protrude from the end portions of the rotating shaft in an axial direction. The sphere members are rotatably supported on the bearing materials.
Thus, a bearing material is not attached at a boundary portion of the rotating shaft which is arranged between the internal portion of the motor case and the portion extending out of the motor case.
The feed screw is formed on the boundary portion of the rotating shaft without waste so that an active length of the feed screw is expanded.
Furthermore, it is possible to shorten the overall length of the rotating shaft in an axial direction, and the boundary portion of the rotating shaft does not need a bearing surface to which the bearing material is attached for polishing of the bearing surface. That


forming of the rolling process and the like is not needed. As a result, productivity and quality are improved.
Preferred embodiments of the present invention will hereinafter be described in detail with reference to the attached drawings.to 5-6x) the amount of minimum-priced tickets available for sale than the Leafs, further devaluing the product they are offering.

Anything to get Rogers happy with the Jays financial situation can't hurt the longterm payroll either. I'm not saying let's give more money to Rogers cuz they're so great. Just saying that if the team becomes more profitable then maybe more gets spent. Hopefully.

The overall expenditure figure for a day out to my ball park is minuscule, compared to the relative costs of daily life in the 21st Century.

I would argue that the Toronto Blue Jays offer the fan a multifaceted and exciting experience not found in any other sports venue.

Just think of Randy Ruiz crushing late inning offerings to the upper deck on a ML minimum salary. Tasty.


 return (ch.mask & mask) > 0;
    }
}

A:

(Of course, choosing Character as the name of your enum is very confusing as it creates a conflict with java.lang.Character which is automatically imported into every compilation unit)
You can use the ordinal() method to get the integer associated with an enum constant. Anyway, I got a feeling that what you are trying to achieve may be realized by enum-defined methods. I mean, Java's enum are more powerful than C/C++'s because you can associate behavior with them.
  public enum Chr {
    A {
       @Override public void doSomething(int c) {
         // some operation ...
       }
 enforcement officers bring to their communities;

For example, under current law, assault with bodily injury is generally punishable as a Class A misdemeanor, while assault on a public servant, including a law enforcement officer, is a 3rd degree felony. Under Governor Abbott’s proposal, in cases where the assault is on a law enforcement officer, the penalty would increase to a 2nd degree felony.

“The recent shooting in Dallas is not the first time law enforcement officers in Texas have been targeted. Our goal is to do everything possible to make it the last,” added Governor Abbott.

Law enforcement organizations in Texas offered the following statements in response to Governor Abbott’s Police Protection Act:

"As a 26-plus year police officer in Houston, I’m extremely encouraged by Governor Greg Abbott’s legislative priority to make


Q:

Update label on button hit, before calling function

I designed a GUI in Scala Swing, where I have a button that should:

update a label
call a function

In this exact order. Now I know, that for updating a label multiple times during the function call, I need to work with threads/actors. But is there an easier way, if I just want to do ONE update (change the label text to "processing") BEFORE doing the computation?
BTW, I know how to use threads, so I don't need any help if there is no easier way. A simple "no" would be enough in that case. But if there is, I would be glad for some help!

A:

Wrap the "call a function" in SwingUtilities.invokeLater()

            expression="get-property('ERROR_MESSAGE')"/>
      </log>
      <makefault version="soap11">
         <code xmlns:soap11Env="http://schemas.xmlsoap.org/soap/envelope/"
               value="soap11Env:VersionMismatch"/>
         <reason expression="get-property('ERROR_MESSAGE')"/>
         <role>error</role>
      </makefault>
      <send/>
   </sequence>
    <sequence name="main">
        <in>
            <spring:spring xmlns:spring="http://ws.apache.org/ns/synapse" bean="springtest"


By Leo Babauta

Something that we struggle with daily, that eats us up and causes stress and anger: annoying people.

You know those people: they cut in line, are rude to you in the office or at the restaurant, cut you off in traffic, talk loudly about obnoxious things, play loud music when you’re trying to concentrate, interrupt you, and so on.

These offenses are violations of the way you think people should act. And so it burns you up. Don’t worry, I’m the same way.

If you just keep letting these offensive people get to you, you’ll always be mad or annoyed. Life won’t be very good. But it’s something you can learn to deal with.

I have to admit I’m not perfect at this, but here are three strategies I usesetAccessible(true) if the method isn't public.
class A {
    public function bypassOverride() {
        echo "Hi from A\n";
        $r = new ReflectionMethod('B', 'override');
        $r->invoke($this);
    }
}

class B extends A {
    public function override() {
        echo "Hi from B\n";
    }
}

class C extends B {
    public function override() {
        echo "Hi from C\n";
        $this->bypassOverride();
    }
}

$c = new C;
$c->override();

The output from this is
Hi from C
Hi from A
Hi from B

You could make bypassOverride() more generic


of malloc() does not return NULL from
 * malloc(0), but I don't think it's a safe assumption.
 *
 * By just bailing out on zero-sized text, we fix both issues.
 */

#include "cairo-test.h"

#define NUM_TEXT 20
#define TEXT_SIZE 12

static cairo_bool_t
text_extents_equal (const cairo_text_extents_t *A,
	            const cairo_text_extents_t *B)
{
    return A->x_bearing == B->x_bearing &&
	   A->y_bearing == B->y_bearing &&
	   A->width     == B->width     &&
	   A->height    == B->height    &&
	   A->x_advance == B->x_advance &&
	   A->y_advance == B->y_advance;
}

static cairo_bool_t
font_extents_equal (const cairo_font_extents_t *A,
	            const cairo_font_extents_t *B)
{
    return A->ascentSpecification EP 675110, 1H-indole-3-glyoxylamides are described which are profiled as sPLA2 inhibitors and are used in the treatment of septic shock, in pancreatitis and in the treatment of allergic rhinitis and rheumatoid arthritis.
It has already been proposed in the German Patent Application having the file reference 19814838.0 to employ the compounds according to DE-A 196 36 150 A1 as antitumor agents.


50%;
  height: 16px;
  width: 16px;
  margin-top: -10px;
  margin-left: -10px;
  display: block;
  position: absolute;
  color: white;
  border: 2px solid white;
  border-radius: 16px;
  box-shadow: 0 0 3px #444;
  box-sizing: content-box;
  text-align: left;
  font-family: 'Courier New', Courier, monospace;
  text-indent: 4px;
  line-height: 16px;
  content: '+';
  background-color: #337ab7;
}
table.dataTable.dtr-column > tbody > tr.parent td.control:before,
table.dataTable.dtr-column > tbody > tr.parent th.control:before {
  content: '-';
  background-color: #d33333;
}
table.dataTable > tbody > tr.child {
  padding: 0.5em 1em;
}
table.dataTable > tbody > tr.child:hover {
  background: transparent !important;
}
table.dataTable > tbody > tr.child ul {
  display: inline-block;
  list-style-type: none;
  margin: 0;
  padding: 0;
}
table.dataTable > tbody > tr.child ul li {
  border-bottom: 1px solid #efefef;
  padding: 0.5em         var file_type = filename.substr(filename.length - 4);
                filename = result[0].name + '_' + number_of_files + file_type;
                number_of_files++;
            }
            fstream = fs.createWriteStream(__dirname + "/" + filename);
            file.pipe(fstream);
            fstream.on('close', function() {
                console.log("Upload Finished


to still have the last chunk(s) of data still buffered in memory. This is why the file may not be completely written to disk by the time finish is emitted.
One common solution for this is to both check a flag that gets set in the busboy finish event handler, and check a counter variable that gets incremented for every fstream close event (comparing it to result.length for example).

A:

As mscdex suggested I used a variable to find when the writing is finised:
var fstream;
var result = [];
var number_of_files = 1;
var counter = 0;
req.pipe(req.busboy);
req.busboy.on('field', function(fieldname, val) {
    field_obj = {}
    field_obj[fieldname] = val;
    result.push(field_obj);
    console.log(field_obj)
});
req.busboy.on('file', function(fieldname, file, filename) {
    counter++;
    console.log("Uploading: "and between patients who survived (n = 35) or died (n = 10) (B). Mann-Whitney U test was applied to assess statistical significance of differences between groups; p-values \<0.05 are indicated by an asterisk (\*).](pone.0038214.g001){#pone-0038214-g001}

Severe H1N1pdm Infection Triggers Increased IL-6 Expression in mice {#s2b}
-------------------------------------------------------------------

Our human clinical data implicated IL-6 in H1N1pdm infection. We next investigated IL-6 expression in mouse models of severe H1N1pdm infection. To observe possible strain variation [@pone.0038214-Otte1], we infected three mouse strains, C57BL/6J mice (n = 17), BALB/cJ mice (n = 17), and B6129SF2/J mice (n = 17), intransally with 10^4^ EID~50~ A/Mexico/4108/2009 (H1N1pdm), and observed survival, weight loss, and IL-6 expression for fourteen days pi.

H1N1pdm infection caused severe disease in mice of all three groups ([Figure 2A](#pone-0038214-g002){ref-type="fig"}). Dramatic declines in weight were observed as of day 3 post-infection (pi) through to days 7--8 pi,


with reductions in percent survival as of day 5 pi. Final percent survival was 36.4% (4/11), 18.2% (2/11), and 0% (0/11) for C57BL/6J, BALB/cJ, and B6129SF2/J mice, respectively. Interestingly, weight loss in BALB/cJ mice slowed slightly at days 5--6 pi, delaying drops in percent survival by one day relative to C57BL/6J and B6129SF2/J mice. Yet, no significant differences in survival curves were observed (α = 0.05). Similar viral loads were detected in the lungs of infected mice at day 3 pi.

![Severe A/Mexico/4108/2009 (H1N1pdm) infection triggered increased IL-6 expression in C57BL/6J, BALB/cJ, and B6129SF2/J mice.\
Survival curves for C57BL/6J (closed squares), BALB/cJ (grey squares), and B6129SF2/J (open squares) mice infected intranasally with 10^4^ EID~50~ A/Mexico/4108/2009 (H1N1pdm). n = 11 for all three groups. The logrank test (α = 0.05) was used to ascertain significance in differencesby IL-6, the expression status of genes associated with the acute phase response was assessed. Using DAVID Bioinformatics Resource v6.7 [@pone.0038214-Huang2], [@pone.0038214-Huang3], multiple functional classifications, most notably Gene Ontology Biological Process, Panther, and Kyoto Encyclopaedia of Genes and Genomes were used to identify functionally related gene networks from all 7,803 probes for significantly differentially regulated genes. Gene Ontology Biological Process classification GO:0002526-- acute inflammatory response was selected as a suitable representation of acute phase response effector genes; the network was upregulated throughout infection ([Table S1](#pone.0038214.s002){ref-type="supplementary-material"}). Results were consistent amongst all classification systems (data not shown). Complementary analysis by qRT-PCR of known IL-6-inducible genes orosomucoid 2 (*Orm2*), serum amyloid A 3 (*Saa3*), serum amyloid A 4 (*Saa4*), *Socs1*, and suppressor of cytokine signalling 3 (*Socs3*) confirmed increased IL-6- inducible


not be a suitable therapeutic target.

Materials and Methods {#s4}
=====================

Ethics Statement {#s4a}
----------------

For clinical studies, written informed consent was obtained directly from each study participant or their legal representative before enrolment. Permission to perform scientific studies was granted by the Comisiόn de Investigaciόn del Hospital Clinico Universitario de Valladolid, Spain. Scientific and ethical approval of the study protocol was also obtained from the Scientific Committees for Clinical Research of each one of the participant centres.

For animal studies, all work was performed in strict accordance with the Canadian Council of Animal Care guidelines. Animal use protocols were approved by the Animal Care Committee of the University Health Network (Toronto, Canada). The University Health Network is certified under the Animals for Research Act (Permit Numbers: \#0045 and \#0085 under the jurisdiction ofat −80°C until immune mediator profiling.

Serum IL-6 Measurement {#s4c}
----------------------

Serum IL-6 levels were measured using the Biorad Luminex Assay Platform (Hercules, CA, USA) at the Infection & Immunity Medical Investigation Unit, HCUV-IECSCYL (Valladolid, Spain).

Animals {#s4d}
-------

Female C57BL/6J, BALB/cJ, B6129SF2/J, and B6.129S2-*Il6^tm1Kopf^*/J (IL-6−/−) mice (8--10 weeks of age) were purchased from Jackson Laboratories (Bar Harbor, MN, USA) and used in influenza studies. Notably, B6.129S2-*Il6^tm1Kopf^*/J (IL-6−/−) were generated from C57BL/6J blastocysts and bred to C57BL/6J mice for 11 generations. Mice were maintained on standard animal feed and water *ad libitum* in clean environmental conditions and controlled temperature and humidity with a 12 hour light and dark cycle. For infection studies, animals were housed in HEPA-filtered cage racks adherent to ABSL2+ conditions (Toronto General Hospital Animal Resource Centre, Toronto, Canada). All animal procedures


as well as between C57BL/6J and IL-6−/− mice. Throughout infection experiments, animal survival, clinical signs, and weights were recorded daily. In accordance with Animal Care Committee recommendation, mice were euthanized when recorded body weight fell below 80% of original body weight.

Viral Load Measurement {#s4f}
----------------------

At days 0 and 3 pi, mice (n = 3) were euthanized and lung homogenates collected for viral load determination. Lungs were homogenized (10% w/v) in High Glucose (4.5 g/L) Dulbecco's Modified Eagle Medium (DMEM), supplemented with 1% bovine serum albumin, 50 µg/mL Gentamycin, 100 U/mL Penicillin, 100 µg/mL Streptomycin, and 1 µg/mL TPCK-Trypsin (vDMEM). Homogenates were then serially diluted (0.5 log~10~) in quadruplicate over Madin-Darby Canine Kidney cells, cultured at 2.0×10^4^ cells/well in 96-well plates. Cells were incubated for 2 hours at 37°C and 5% CO~2~.UN.INC @ NOVO

NOVO IS NOW OPEN FOR CAMPERS AND IMPACT FOCUSED WEEKEND RETREATS.

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The land is beautiful, it's a great place to get away and write and create or to crash while you're here for a festival or event. Our land is a few minutes from the COTA racetrack and 30 mins from downtown Austin. While you're here, get a behind-the-scenes experience of Novo in progress.

ready to camp?

If you're interested in camping, you can book ahead on Hipcamp or if you're traveling and don't know your schedule just show up


Q:

R dygraphs - plot certain content of columns

I have a csv file "fruit.csv" looking like that:
"Date","Fruit","Count"
2019-01-01,Apple,3
2019-01-01,Pear,5
2019-01-01,Banana,4
2019-02-01,Apple,4
2019-02-01,Pear,4
2019-02-01,Banana,6
...

I want to plot the data having the date in the x-axis and the number in the y-axis. Especially, i want the graph to only show the data of a certain fruit, e.g. only apples.
This is what I have until now, plotting all fruits at once:
data <- read.csv("Path/to/fruit.csv")

data$Date <- as.Date(data$Date)

time_series <- xts(data$Count, order.by = data$Date)
dygraph(time_series)

What do I need to add, to specify the fruit I want to plot?

A:

Here are some approaches:
First, use dplyr to filter() the data ahead of time:
library(dplyr)
apples <- data %>%
  filter(Fruit == "Apple")
apples_ts <- xts(apples$Count, order.by = apples$Date)
dygraph(apples_ts)

Second, subset the data in a more traditional way ahead of time.
apples <- data[which(data$Fruit == "Apples"),]
apples_ts <- xts(apples$Count, order.by = apples$Date)
dygraph(apples_ts)

Third, subsetTuesday, March 21, 2006

Resources for action

ALBANY -- Bearing banners, peace flags and signs, about 200 protesters marched on a downtown federal building to call for an end to the Iraq War and to demand American troops be brought home before more lives are lost.

The United States Conference of Catholic Bishops offers resources for dioceses and parishes here.

“Our nation cannot afford a shrill and shallow debate that distorts reality and reduces the options to ‘cut and run’ versus ‘stay the course,’” said Bishop Wenski. “Instead we need a forthright discussion that begins with an honest assessment of the situation in Iraq and acknowledges both the mistakes that have been made and the signs of hope that have appeared. Most importantly, an honest assessment of our moral responsibilities toward Iraq


Enhanced growth suppression of TERT-positive tumor cells by oncolytic adenovirus armed with CCL20 and CD40L.
Conditionally replicating adenoviruses (CRAds) selectively replicate in cancer cells and induce cell lysis, which represents a potential platform for cancer immunotherapy. The chemokine CCL20 exerts antitumor activity via chemoattraction of immature dendritic cells (DCs) and lymphocytes. However, the activation and maturation status of DCs is a limiting factor in the DCs -based immunity response. CD40L induces the phenotypic maturation of DCs, mediates DCs cytokine secretion, and increases the expression of FasL, which mediates apoptosis. We constructed a CCL20/CD40L co-expression CRAds (Ad-CCL20-CD40L) based on the AdEasy system. Ad-CCL20-CD40L was constructed from three plasmids, pGTE-CD40L, pShuttle-CMV-CCL20 and AdEasy-1, and was homologously recombined and propagated in the Escherichia coli strain BJ5183 and the packaging cell line HEK-293,of the Pomeranian Medical University in Szczecin approved the study protocol, and all patients provided written informed consent prior to participation.

Patients and blood samples {#s2b}
--------------------------

A total of 142 individuals with generally good and stable health were included in the study. These patients were divided into groups: a "cancer" group (newly diagnosed pancreatic adenocarcinoma, n = 43), an "other malignancies" group (pancreatic neuroendocrine tumors \[NETs\], n = 10; solid pseudopapillary tumors \[SPTs\], n = 3), an "other pancreatic diseases" group (acute/chronic pancreatitis, n = 31; pancreatic cysts, n = 14), and a "control" group (healthy volunteers, n = 41).

The final diagnosis of pancreatic adenocarcinoma and other malignancies was based on biopsy specimen analysis. In order to establish disease staging, all patients underwent ultrasonography, computed tomography and/or endoscopic ultrasonography, as well as chest x-ray examinations. In the "cancer" group, 6 patients qualified


       6.08±1.75                             8.82±3.50                                   6.84±2.12
  CRP (mg/L)                            2.91±1.84     13.40 \[4.80; 70.20\]\*\*[\#](#nt104){ref-type="table-fn"}     3.00 \[1.85; 7.00\]
  CA19.9 (U/mL)        using the Pearson test or Spearman rank test, according to the normality of the distribution. To evaluate the effects of continuous variables on pancreatic cancer staging and levels of cytokines, multivariate regression analyses were performed using a stepwise selection method. Variables excluded from the initial model were re-entered individually to exclude residual confounding. During development of multivariate regression models, the number of inserted independent variables did not exceed 10% of the total number of analyzed patients. Constructed models were verified using the Akaike information criterion (AIC), and wrongly constructed matrices resulted in rejection of the model. Receiver operating characteristic (ROC) curves were constructed for all parameters analyzed as diagnostic for pancreatic cancer, and the area under each ROC curve (AUC) was calculated. The current study has been performed


between cytokines and pancreatic cancer {#s3d}
-------------------------------------------------------------

Finally, we verified potential associations between systemic levels of cytokines and the clinical presentation of pancreatic malignancy in our patients. Using multivariate regression analyses we found that, among all examined cytokines, only IL-8 levels in patients with pancreatic cancer were strongly associated with disease advancement. The IL-8 concentration also seemed to be associated with or influenced by IL-6 and TNFα levels in patients with pancreatic adenocarcinoma ([Table 2](#pone-0097613-t002){ref-type="table"}).

10.1371/journal.pone.0097613.t002

###### Analysis of associations between levels of examined cytokines and clinical presentation of pancreatic cancer in patients (modelling using multivariate regression analysis).

![](pone.0097613.t002){#pone-0097613-t002-2}

  Dependent variable                               for the detection of pancreatic cancer in humans. To determine whether systemic levels of cytokines could serve as novel makers of pancreatic adenocarcinoma, we added a group of patients who were hospitalized or diagnosed with other pancreatic diseases (acute/chronic pancreatitis or pancreatic cysts) to our analyses. After measuring cytokine levels (IL-6, IL-8, IL-10, IL-23, TNFα) in this group, we added these patients to our analyses, constructed ROC curves, and determined the approximate AUC values to assess the suitability of these cytokines as diagnostic markers for pancreatic cancer. Among all examined parameters, only those with a 95% confidence interval (CI) lower bound value that exceeded 0.50 are presented and precisely described ([Figure 3](#pone-0097613-g003){ref-type="fig"}). Our analysis demonstrated that IL-6, IL-8, IL-10, and TNFα are promising novel candidate markers for the


IL-6, IL-8, IL-10, and IL-23 levels significantly differed between patients with pancreatic cancer and other individuals. From a molecular standpoint, elevations in the levels of these ILs may strongly promote cancer progression in patients with pancreatic malignancies, as these cytokines are involved in the activation of multiple upstream signaling pathways that influence the activity of numerous transcription factors, modulate the cellular proteome at both the genetic and translational level, and promote the development of an "immunosuppressive" Th2 immune phenotype profile [@pone.0097613-Kuwada1]--[@pone.0097613-Matsuo2], [@pone.0097613-Waugh1]--[@pone.0097613-Zhang1]. Surprisingly, we did not see significant differences in the levels of other ILs that we examined, which are known to stimulate immune response [@pone.0097613-Malvicini1], [@pone.0097613-Benatar2], [@pone.0097613-Tjomsland2] and could beneficially promote immune aggression against cancer cells leading to their successful elimination. All these results confirm and translateACLU has joined people and groups calling on the team we side with the Dude

Unfortunately, a problematic trademark law, the Lanham Act The team took the case to court, and the ACLU filed anyesterday arguing that the government cannot constitutionally deny trademark benefits on the basis of speech that it disagrees with or finds controversial. Our brief is on behalf of the First Amendment, not the Redskins. Thethe loud chorus ofto change its name (from "The Big Lebowski" on this one), but the government should not have the power to make decisions about which trademarks are too "immoral," "scandalous," or "disparaging" to be given trademark protection.Unfortunately, a problematic trademark law,, gives it that very power.

Perhaps unsurprisingly, these vague terms have led to a host of arbitrary decisions about


to every Christian you know. Save a child or lots of children!!!! Do Something, please!

Please note: All my writings and comments appear in bold italics in this colour

Wednesday, 7 September 2016

A Priest, A Petting Zoo Guy, A Mormon, 3 New Yorkers on Today's P&P List

Priest who demanded homosexuals have a ‘celibate life’ suspended after being accused of molesting 15-year-old boy in the Bronx

Father Anthony Giuliano in September 2004BY ROCCO PARASCANDOLAGRAHAM RAYMANTHOMAS TRACYNEW YORK DAILY NEWS

A priest who once said homosexuals had to live a “celibate life” to be good Catholics has been accused of molesting a 15-year-old boy at a Bronx church about 30 years ago.But without a change to the statute of limitations on child sex abuse in New York, the alleged crimes committed by the manpriests in New York State,” Doyle said. “We know about more accused priests in the diocese of Manchester, New Hampshire than we do in the Archdiocese of New York.”

Baychester, NY

Former petting zoo employee indicted for

child sexual abuse

By Tom Smith Senior Staff Writer, Times DailyFLORENCE – A man working with the pony ride of a traveling petting zoo has been indicted on multiple counts of child sexual abuse.Daryl Victor Raymond Jr., 48, of School Street, Stockholm, Maine, has been indicted on six counts of unlawful sexual abuse of a child under 12.

According to the indictments, the children were are all girls between the ages of 3 and 6.

The indictments were issued during the recently concluded August grand jury session. In the indictments, Raymond is accused of subjecting a child


past.

New York Mills man accused of child sexual abuse

By WKTVNEW YORK MILLS, N.Y. – A New York Mills man has been charged for allegedly sexually abusing a child after a five-year investigation.David R. Burr, 37, was indicted by an Oneida County Grand Jury and charged with felony criminal sexual act for allegedly sexually abusing a 10-year-old in Utica, according to Chief Deputy Joseph Lisi.
Rome Police detectives Richard Galluppi and Jason Worth, both formerly assigned to the county Child Advocacy Center, led the investigation. They said that on January 20, 2011, Burr sexually abused the child in Utica.

A five year investigation? Five years? Wow!

The investigation involved numerous members of the Advocacy Center, including Child Protective Services caseworkers, victim advocates and counselors who assisted the victim throughout the investigation.

Burr was---
abstract: 'We study the quantum hydrodynamical features of exciton-polaritons flowing circularly in a ring-shaped geometry. We consider a resonant-excitation scheme in which the spinor polariton fluid is set into motion in both components by spin-to-orbital angular momentum conversion. We show that this scheme allows to control the winding number of the fluid, and to create two circulating states differing by two units of the angular momentum. We then consider the effect of a disorder potential, which is always present in realistic nanostructures. We show that a smooth disorder is efficiently screened by the polariton-polariton interactions, yielding a signature of polariton superfluidity. This effect is reminiscent of supercurrent in a superconducting loop.'
author:
- 'A. Gallemí'
- 'M. Guilleumas'
- 'M. Richard'
- 'A. Minguzzi'
bibliography:
- 'bibtex.bib'
title: 'Interaction-enhanced flow of a polariton persistent current in


a ring'
---

Superfluidity is a striking feature of quantum fluids. It is characterized by an irrotational particle flow, which is frictionless below a critical velocity. Superflow is a typical manifestation of a superfluid: when the latter is trapped in a ring and set in circular motion, it will exhibit (i) an integer angular momentum in units of $\hbar$ and (ii) a vanishing decay of the current. This phenomenon has been observed a long time ago in a superconducting loop below the critical current [@File1963], with superfluid Helium [@Reppy1964] and more recently in ultra-cold atom condensates [@Ramanathan2011].

Exciton-polaritons, in spite of their nonequilibrium character have also been found to display many features of superfluidity, like frictionless flow [@Amo2009], quantized vortices [@Lagoudakis2008; @Lagoudakis2009; @Sanvitto2010], and Bogoliubov dispersion [@Kohnle2011]. A specific feature ofis not directly imprinted by the excitation laser phase pattern. We then investigate the competition between this angular momentum generation mechanism, and the backscattering due to disorder within the ring.

In presence of disorder, Bose fluids are subject to localization, i.e. Anderson localization for vanishing interaction [@Anderson1958], or many-body localization in the strongly interacting case [@Basko2006; @Basko2007]. These localization mechanisms hinders the quantum fluid flow. However, repulsive interactions also screen the disorder experienced by the fluid, which on the contrary, helps restoring the flow, such that the net effect of interactions in presence of disorder is in general not easy to determine. Note that such a screening effect has been reported already in a disordered polariton condensate [@Baas2008] and in ultracold atoms in harmonic traps [@Deissler2010] (see e.g. [@Modugno2010]


of spin-to-orbital angular momentum conversion using numerical simulations of the coupled driven-dissipative Gross-Pitaevskii equations for the ring-trapped condensate. In Section \[sect:disorder\], the interplay between interactions and disorder is analyzed, and the suppression of persistent currents is estimated. Finally, in Section \[sect:conclusions\] we summarize our results and discuss perspectives.

The model {#sect:model}
=========

Polaritons are bosonic quasi-particles of mixed exciton-photon nature, that exist in semiconductor microcavities in the strong coupling regime [@Carusotto2013]. In this work, we consider the lower polariton state, the dispersion of which is well described by a two-coupled harmonic oscillator model as $E_{\rm pol}=\frac{1}{2}
\left(\hbar \omega_c(k)+E_{\rm x}\right)-\frac{1}{2}\sqrt{\left(\hbar \omega_c(k)-E_{\rm x}\right)^2+4\Omega^2}$, where $\Omega$ is the exciton-photon Rabi splitting, $E_{\rm x}$ is the exciton energy, and $\hbar\omega_c(k) \simeq E_{\rm c}+\hbar^2k^2/2m_{\rm eff}$ is the bare cavity photon dispersion characterized by an effective mass $m_{\rm${\cal L}_z$ in the numerical calculations. The bottom panel represents the density profile (in arbitrary units) along the ring at $r=R_0$ for different values of the interaction constant $g$ and disorder strength $U_0$: $g=0$ meV$\mu$m$^2$ and $U_0=5$ meV (dot-dashed green line), $g=0.6$ meV$\mu$m$^2$ and $U_0=5$ meV (solid red line), and $g=0.6$ meV$\mu$m$^2$ and $U_0=8$ meV (dashed blue line).[]{data-label="Fig4"}](fig4.pdf){width="0.9\linewidth"}

In the previous section, we have shown that when we excite the $\sigma^+$ polariton component into a mode carrying no angular momentum in a smooth ring-shaped trap, the $\sigma^-$ component acquires a persistent current with winding number $2$. In this section we account for the fact that in realistic experiments, a (gaussian-distributed) disorder potential $$V_{\rm dis}(\vec r\,)=\mbox{Re}\left[\mathcal{F}^{-1}[2\pi^2 l_c U_0 \exp(i\varphi_{\vec k})\exp(-k^2 l_c^2/4)](\vec r\,)\right]\,,$$ experienced by polaritons is present within the ring,


where $S\leq {{\mathbf{\uppercase{a}}}}^X$ and $T\leq {{\mathbf{\uppercase{a}}}}^Y$ for some partition $\{X,Y\}$ of $U$. Since $M_U\not=A^U$, either $A^X\neq S=\pi^{{{\mathbf{\uppercase{a}}}}^U}_X(M_U) = \pi^{{{\mathbf{\uppercase{a}}}}^n}_X(M)$, or $A^Y\neq T=\pi^{{{\mathbf{\uppercase{a}}}}^U}_Y(M_U) = \pi^{{{\mathbf{\uppercase{a}}}}^n}_Y(M)$. Either way, one obtains that $X$ or $Y$ is a proper subset of $U$ that is a support of $M$, contradicting the minimality of $U$.

For the final statement of the lemma, if the minimal support of $M$ is $[n]$, then $\pi_{[n]}(M)=M$ is critical by the second statement of the lemma. Conversely, assume that $M$ is critical and $U\subseteq [n]$ is its minimal support. Since $M = M_U\times A^{U'}$ and $M$ is directly indecomposable as a relation, we get $U' = \emptyset$, equivalently $[n]=U$.

The parallelogram property for critical relations {#parallel}
=================================================

In the preceding section we showed that all maximal subuniverses of ${{\mathbf{\uppercase{a}}}}^n$ are induced by criticalsource. If it would have come only from myself, none of you would have ever believed it, as you all have a direct contact to your higher selves and know many things even better than I do. This is what most external observers do not seem to get when they try to criticize our website and its content. This, I must admit, happens very rarely as the coward Anglo-Saxon New Agers have realized in the meantime that we are strong in our arguments and never fear an open “clash of ideas” even a “clash of civilizations”, as all members of the PAT come, indeed, from much higher evolved civilizations than the ones pertaining to the GF, who do some of the channelings in addition to the overwhelming dark


his knee."

The 6-foot-5, 242-pound Tatman, who is still waiting to hear if the NCAA will grant him an expected sixth year of eligibility, strained his medial collateral ligament Tuesday and will not practice the rest of the spring.

But it is Stormo who has caught everyone's eye.

The Everett native added about 10 pounds of muscle in the offseason – he's 6-5 and 257 pounds – which has turned a weakness – a lack of confidence – into a strength.

"He's made the biggest strides," said tight ends coach Rich Rasmussen. "He's got a better grasp of the offense and he's finally playing with some confidence. That was his big hurdle he had to get over a year ago."

"I take everything a little too serious at times," Stormo admitted. "I'm hard6-foot, 224-pound walk-on Jared Byers.

"Andrei has made some significant progress, so we're mixing and matching him a bit, cross-training him at just so we have some depth," Rasmussen said.

In the fall, four-star recruit Aaron Dunn from Mead High will also be in the mix, giving the Cougars even more depth. There is so much confidence in the group now, even with Tatman's injury, 6-4, 242-pound redshirt freshman walk-on Elliot Bosch was moved inside Thursday and worked at center and guard.

• A couple of notes to start. New athletic director Moos began moving into his Bohler Gym office today, though he has yet to officially start his new job. But with just a couple of weeks to go until May 1, which he said would be the very latest


couldn't get out of its way, moving the ball about 9 yards in the first nine plays during an early 2-minute team drill. But in the practice ending team work, the first-team offense shined. Jeff Tuel found Daniel Blackledge for a long score and he teamed with Logwone Mitz for another long touchdown, the latter coming on a screen to the left that caught the defense in an all-out blitz. "Really, just at the end of practice in the team segment, they made some plays," Wulff said. "We weren't very consistent in skelly, we weren't real consistent in blitz but as the practice finished we started catching balls. And when you catch the ball, we can move the ball." ... During the aforementioned skelly drill, Daniel Simmons gatheredand a regular alliance with Loefah and Swamp81 which led to his The Boss album for Swamp last year.

He remains seriously in demand, and his recent parties at Fire in London – for his birthday and then the launch of his new Biasonic label – have been immense. But then a couple of days ago he phoned up FACT to say he’s retiring from DJing. Knowing what a sharp operator he is, we guessed that there was more to the story, and were keen to know what this was all about – so we got on Skype with him to ask about his plans, life lessons and thoughts on the state of the industry.

So we heard you had an announcement… what’s happening with you?

Well, I’m getting older, aren’t


customer. If there is no convincing value proposition, then there is no success.

Think outside the traditional realm of exotic vids and world champs. What business model will allow you to start small, offering a good value proposition, and not have to compete with the big players directly?

sijandy wrote:Interesting point, have been thinking about this myself. I've been making my own boards for a few years now as a hobby and have been contemplating the feasability of actually creating a brand and trying to sell them. I know i can make a board just as good as any profuction boards out there but how do you compete without exotic promo vids and world champs riding your gear?

Unfortunately you can't compete. Think of any piece of sporting equipment world-wide andourselves... and the more we work on ourselves the more prepared we are to participate in healthy/fun/peaceful/happy/_insert adjective of choice_ relationships with others.

I think there is only one reason to ever enter into a relationship. You don't enter a relationship for what you might get out of it (though you might get a lot). You enter a relationship to connect with another person who shares the desire to connect with you. During the course of that connection, there might be great joy, great sadness, great peace, great turmoil, great pleasure, and great pain. Relationships, like everything else, are impermanent and subject to constant change. Perhaps peace and happiness are found in realizing just that.


Vatican makes it easier to punish abusive priests

New norms also strengthen penalty for attempting to ordain women as clergy

The Vatican has revised its procedures for handling priestly sex abuse cases, streamlining disciplinary measures, extending the statute of limitations and defining child pornography as an act of sexual abuse.

Vatican officials said the changes allow the Church to deal with such abuse more rapidly and effectively, often through dismissal of the offending cleric from the priesthood.

As expected, the Vatican also updated its list of the “more grave crimes” against Church law, called “delicta graviora”, including for the first time the “attempted sacred ordination of a woman”. In such an act, it said, the cleric and the woman involved are automatically excommunicated, and the cleric can also be dismissed from theis understood from the context of the conversation.

Regarding the Eucharist, the revised norms modify the language concerning the attempted and simulated celebration of the Eucharist, and sacrilegious consecration of one or both matters in the Eucharistic celebration or outside of the Eucharistic celebration.

The revised norms include for the first time “crimes against the faith” – heresy, apostasy and schism – saying that while competency normally falls to local bishops in such cases, the doctrinal congregation becomes competent in the case of an appeal.


Our Earth is beautiful, wonderful, fascinating, challenging and full of wonders. This page will open all the beauty of our planet. Most of us enjoy travelling all around the world. This page will help you to see and travel to the places you’ve never been before. Enjoy the beauty of the Earth!!!WASHINGTON (CNN) -- Most Americans like their health care coverage but are not happy with the overall cost of health care, a national poll shows.

President Obama has said that lowering health care costs will benefit the economy.

More than eight in 10 Americans questioned in a CNN/Opinion Research Corp. survey released Thursday said they're satisfied with the quality of health care they receive.

And nearly three out of four said they're happy with their overall health care coverage.

But satisfaction drops to 52 percent when it comes to the amount people pay for their health care, and more than three out of four are dissatisfied with the total cost of health care in the United States.

"When Americans say they support health care reform, that doesn't mean they want to lose their


sure to clearly indicate how each party to your contract will be referred to in the rest of your contract as well (e.g., "hereinafter referred to as consultant").

Commonly, a consultant will be an individual entering into a contract with a company looking for the consultant's services. For instance, a law firm may hire an individual consultant who has expertise in hiring and firing practices.

2

Detail the consideration each party is providing. In short, clear, readable paragraphs, explain what each party is providing under your contract. At this point, there is no need to get incredibly detailed. Most of the time you only have to state that one party is providing consulting services and the other party is providing compensation.

For example, an acceptable provision may state: "The customer is ofelse to try to contract with.

The other party might try to negotiate some of the terms of your contract. If this happens, you will negotiate with the other party until you both reach an acceptable agreement.

2

Negotiate any differences about the terms of your contract. When you negotiate over the terms of your consulting contract, it will most likely be over payment for services and/or the types of services the consultant is going to perform. These will be common areas of tension because they are the main parts of your contract.

3

Sign your contract and begin performing. When you and the other party are satisfied with the document, you will both sign it and begin performance in the manner you both agreed upon.

Tips

You should always try to find a form


located on the right column. Conversely, if you're not sure what you're looking for, you can browse our file article directory by file type or starting alphabet letter.

File Central Resources

MIME Types - A list published by Harvard University of the most common MIME types and their corresponding file extensions.

Assigning Windows File Associations - An Indiana University file resource that explains how to associate a file extension type with a software application in Microsoft Windows.on that device.

Uber addressed that issue. “This letter requires you to turn over information wherever located, including but not limited to, your personal devices, and to waive any Fifth Amendment protection you may have,” Yoo wrote.

The letter sets up a showdown between Uber and the man whose company it paid $680 million to acquire — a man who is a close confidant of Uber CEO Travis Kalanick.

“I feel like we’re brothers from another mother,” Kalanick said of Levandowski, according to Bloomberg, which reported the CEO courting the engineer during long evening walks in San Francisco from SoMa to the Golden Gate Bridge.

When Uber bought Otto, Kalanick put Levandowski in charge of Uber’s self-driving research, an effort the CEO considers crucial to his company’s future. As the lawsuit heated


Q:

HttpUtility.HtmlDecode not decoding spaces?

I have this
 string test =  HttpUtility.HtmlDecode("http://test.com/Folder1/Folder2/my%20view.aspx");

When I look into test it still has %20 instead of a space. Why is it not decoding this?

A:

You are looking for HttpUtility.UrlDecode() (in the System.Web namespace, I think)

A:

HttpUtility.HtmlDecode not decoding "%20", use HttpUtility.UrlDecode to decode "%20"

1. Plaintiff shall have until January 14, 2008 in which to either show cause why this case should not be dismissed pursuant to 28 U.S.C. §1915(g) or pay the full $350.00 filing fee. In the absence of either action by Plaintiff, this matter will bedismissed without further notice. 2. The Clerk of the court is directed to set a pro se case management deadline in this matter with the following text: January 14, 2008: Deadline for Plaintiff to show cause or pay full filing fee.3. The Clerk of the court is directed to terminate the previous pro se casemanagement deadline in this matter. Pro Se Case Management Deadlines: Pro Se Case Management Deadline set for 1/14/2008: Deadline for Plaintiff to show cause or pay full filing fee. Ordered


174 U.S. 64 (1899)
COSGROVE
v.
WINNEY.
No. 172.
Supreme Court of United States.
Submitted January 19, 1899.
Decided April 24, 1899.
APPEAL FROM THE DISTRICT COURT OF THE UNITED STATES FOR THE EASTERN DISTRICT OF MICHIGAN.
*66 Mr. E.H. Sellers and Mr. Cassius Hollenbeck for appellant.
Mr. Solicitor General for appellee.
MR. CHIEF JUSTICE FULLER delivered the opinion of the court.
Article three of the Extradition Convention between the United States and Great Britain, promulgated March 25, 1890, 26 Stat. 1508, and section 5275 of the Revised Statutes, are as follows:
"Article III. No person surrendered by or to either of the High Contracting Parties shall be triable or be tried for any crime or offence, committed prior to his extradition, other *67 than the offence for which he was surrendered, until he shall have had an opportunity of returningon this record that, because of Cosgrove's temporary absence, he had waived or lost an exemption which protected him while he was subject to the state authorities to answer for the offence for which he had been extradited.
The case is a peculiar one. The marshal initiated the prosecution in the state courts, and some weeks thereafter the indictment was found in the District Court for the same act on which the charge in the state courts was based. The offences, indeed, were different, and different penalties were attached to them. But it is immaterial that Cosgrove might have been liable to be prosecuted for both, as that is not the question here, which is whether he could be arrested on process from the District Court before the prior


         For h = 719 To 748
                    .Rows(i).Hidden = .Range("G" & i).Value = 0
                    .Rows(g).Hidden = .Range("G" & g).Value = 0
                    .Rows(h).Hidden = .Range("G" & h).Value = 0
                 Next i
             Next g
   of 18 and 55 years was processed without stabilizer for HV study 2.

At approximately 8:00 am, a spot urine sample was collected (up to 120 mL) and placed on ice as soon as possible. Up to 50 mL of urine was centrifuged at 2,000× *g* at 4°C for 10 minutes, the supernatant was collected, and biotrin urine stabilizer added at a ratio of 1:4 (for HV study 1). Aliquots of 1.5 mL were delivered to labeled tubes and frozen at −80°C until shipment to the analytical laboratory (Rules Based Medicine, Austin, TX, USA) where the samples were thawed and analyzed using multiplex assay/assays for A1M, B2M, calbindin, clusterin, connective tissue growth factor (CTGF), creatinine, cystatin-C, glutathione *S*-transferase α (GSTα), KIM-1, microalbumin, NGAL, osteopontin, Tamm--Horsfall urinary glycoprotein (THP), tissue


God." "(BOTH SQUEAL)" " (LAUGHS)" " You're a goddess." "You're literally a goddess." " Guys..." " Hi." "This is Pippa." " Hello." " BLAIR:" "The famous..." "Frankie, Blair, Alice." "Hey, what's up?" "My God, you guys are meeting for the first time, this is so exciting." " I know." " Nice to meet you." "This is so weird, you guys, because it's sort of like you're all Jess's best friends, I'm Jess's best friend." "And so it's sort of like we're all already best friends, you know?" "Well, it's a little different for us, sorry to interrupt, but, uh, Jess and I were freshman year roommates, so it's kind of like family." "Eh." " I know, I know." " Um, okay, I'm going to grab a chair." "Feelit" "Rock your body, and it all makes sense" "Got me up under your influence" "I'm getting us drinks." "Knockout blurry, no worries" "You guys, you guys, let's get Jess a stripper!" " Yes!" " Oh, yeah." "Okay." "Right?" "You guys, you guys, you guys, male or female, though?" "Male." "I'm thinking male for her." " Yeah." " Okay, I got it." "Frankie, do you have a tampon?" " I need one." " Uh-huh, yup." " Thank you." " Got one." "Here we go." "What day of your flow are you on?" "Oh, no, no." "It's our code." "In college, we would ask each other for tampons if some guy was skeezing us out and we wanted to be saved." "You just say "tampon," and they run." "PIPPA:"


gonna warn you now." "Uh, did not have time to self-wax, so it is like a jungle down there." " BLAIR:" "Self-wax?" " Yeah." "Like, with those weird little, like, paper strips?" "Yikes, dude." "Even I'm like, "Yikes, dude."" "Look, you guys, I don't understand." "Why all the hate?" " (DOORBELL RINGS)" " Ooh." " Mmm." " Okay, I got it, I got it." " Well, that was fast." " But, seriously, we're gonna talk about this self-wax thing later." " Okay, come on." " Ooh." "(POUNDING ON DOOR)" " Hey..." " Oh, not bad." " Stripper's here!" " (ALICE WHOOPS)" " You guys!" " Yes!" "I don't want a stripper!" "Did you bring a CD or anything?" "Like, Now That's What I Call Music!" "or anything?" "Mansploitation, bitch!" "Yes!" " (WHOOPING)" "Let's get to the beans, let's get to the beans." "Yeah, just do it." "Get it over with." "Get it over with!" " (LAUGHING) So good!" " Love her." "Make her feel special." "(GASPS)" " ALICE:" "Yes!" " BLAIR:" "Get that!" " (WHOOPING)" " JESS:" "Oh, he's warm." "Ooh, all right." "I like it." " (WHOOPS)" " JESS:" "Okay." "I know you want it, you little slut." "Oh, God!" "No!" "Ew." "Gross." "You sit down." " (CLEARS THROAT)" " So aggressive." " FRANKIE:" "I'm definitely gay." " Okay, my turn!" " (GRUNTS)" " Whoa, whoa, whoa." " Oh!" " Oh, shit!" "FRANKIE:" "Holy shit." " I'm good!" " JESS:" "Hey." "Are you okay?" "Oh, him?" "He's fine." "You're okay, right, bud?" "Oh, God."


All right." " Okay." " ALICE:" "You all right?" " You all right?" " Good." "Oh, my God, Pip, I can see all of his teeth marks." "That looks really bad." "No, no, no." "This is..." "That's not..." "I'm good." "Yeah, she's fine." "Look at her in the eyes." "Okay?" "So let's just get the body out of sight, and then we'll put him back before we call the cops." "Yeah?" " Let's do it." "Right?" " Yes." " Let's go!" "Okay!" " Let's do it." "PIPPA:" "Hold the door." "Hang on one sec." " ALICE:" "Got it." " JESS:" "There's two steps here." "Hold on." " Yeah, we got it." "Ow." " ALICE:" "Oh, there's two steps." "(LOUD CRASH)" " PIPPA:" "Put him down." " ALICE:" "Thatyour judgment." "Blair, I would never judge you for something like that." "Oh, my God, my students." "They idolize me." "They think I'm, like, the best fucking adult in the whole fucking world." "They'll turn to crime." "I can't go to jail." "I couldn't even make it through the first episode of Orange Is the New Black." "(CRYING) None of us can." "(SNIFFLES) It's too soapy, right?" "No, I meant none of us can go to jail." "(SNIFFLES)" "PIPPA:" "Wait, you guys." "Even if we don't get charged with this tampering with evidence thing, we don't know who this man is." "His family could come seek revenge." "He could be part of a cartel that's gonna cut off our toes and stick them up our bums." "BLAIR:" "She's


"Okay." "That's it." "None of them are picking up." "That means something really bad happened." "Dude, this is, like, the third girlfriend that's cheated on you." "What is that?" "What's going on, buddy?" "Does your dick bend weird when it gets hard?" "No." " All right." " JAKE:" "Doesn't matter." "Let's get you on Tinder right now, so you can start on a rebound." " No, I don't want to be on Tinder, okay?" " PATRICK:" "Come on." "You've gotten over other girls, you can get over her." "Yeah, this isn't some girl, this is Jess." "I'm not gonna get over her, you know?" "And I don't want to get over her." "Then, this time, do something about it, Peter." "(TOBEY SCOFFS)" "You're right." "You're right, I gotmotherfucker" " What, what, what, what" "La-da-da-da-dah" "You know I'm mobbin' with the D-O-double-G" "Straight off the fuckin' streets of C-P-T" "King of the beats, you ride to 'em" " In your Fleet" " Fleetwood" "Or Coupe de Ville rollin' on dubs" "How you feel?" "Whoopty-whoop, nigga, what?" "It's the next episode" "(OTHERS GRUNTING)" " JESS:" "Jesus Christ." " ALICE:" "It's not that bad." " I think it's the body on top." " (OTHERS GRUNTING)" " Okay, okay, okay, okay." " Okay." "Okay, wait, does anyone know how to actually drive this thing, or..." "PIPPA:" "I could do it." "I, uh, I took one to school every day growing up, so, I feel pretty confident." " Great." " Perfect." " LEA:" "Hello!" " JESS:" "Oh, shit." " Hello!"


" (LIQUID SPLATTERING)" "You are peeing." "I'm so scared." "I feel like we should say something." " FRANKIE:" "Yeah." " BLAIR:" "Yeah." "Good idea." "We're really sorry." "You deserved better." " BLAIR:" "Mmm." " FRANKIE AND ALICE:" "Yeah." "There's nothing we could do to bring you back, but..." "We promise to spend the rest of our lives trying to be better people." " We owe that to you." " ALICE:" "Mmm-hmm." "God, we're so sorry." "So sorry." "So sorry, man." "We suck." "(SIGHING, SNIFFLING)" "Okay, you can dump him now!" "Aye aye, Captain." "(STARTS ENGINE)" "This never happened." "Right?" " Nope." " It..." "It happened." "Right?" " No, we're not gonna talk about it." " Oh, got it, got it." "Okay, bye. (GRUNTS)" " BLAIR:" "Oh." " JESS:""After that, we didn't want to pay for the service." "LEA:" "You know, they keep out the riffraff." "You'll just have to jerk off as the Italians do." " To your memories." " Mmm." "Wait, so, Blair, so there's no footage?" " (URINATING)" " No." " Ah!" " Oh, my gosh." "So we're in the clear!" " (LAUGHING)" " That is..." "That's great." " Yeah." " BLAIR:" "She was so intuitive." "She was inside me." "And then she was outside me." "And then she was me." " So, we're good." " Almost, except I probably have HPV now." "Whatever." "We all have HPV." "Oh, uh, I mean, I don't have HPV." "Alice, they say if you had sex after the year 1991, you have HPV." "Then, I mean,


got to do a little bump, though, so I know that you're not a cop." "No, man." "Please." "I'm not a cop." "You want the meth or not?" "Okay." " Yay!" "Here we go." " (SNIFFS)" " And one for Papa Bear." " It burns." "All right." "40 bucks." "Not a cop." "Come on." " (QUIETLY) Yes." "Great." "Thank you." " You're welcome." "So, uh, still a no-go on the BJ, or..." "No, I'm good." "Thanks." "That's fine." "Actually, there's somebody I want to introduce you to." " Right on!" " Very nice to meet you." " Good to meet you, too." " This is so perfect." " Yeah, go." "Please, go." " Okay." "Okay." "You got to do it, man." "That's true love." "♪♪" "Guys, I fell"What?" "It wasn't." "How could you not invite me?" "Alice, please." "Please, can we drop it?" "Please." "I'm telling you, it was just..." "It was for Peter's family." " It wasn't a big deal, man." " Oh, Peter." "He is so annoying." "And I know why he doesn't like me." "'Cause he's, like, so freaking jealous." "Peter is not jealous of you." "Well, then, why would you not invite your best friend to your bridal shower?" " Oh, my God, you really want to know why?" " Yes!" "I do!" "Because I knew that if I invited you, you wouldn't let me talk to anybody else." "That's why." "Okay?" "You monopolize my time and then you make me feel guilty about not spending time with you." "How can


really does have a gun!" "FRAZIER:" "Let's go!" "Come on." "You, too." "Move it." " Oh, my God." " RUIZ:" "Playtime's over." " We want those fucking diamonds now." " FRANKIE:" "Look." "I know you're mad at the 1%." " I am, too." " What?" "Shut up!" " Tie them up now." " Let's go!" "(GROANING)" "(SIGHS)" "(SIGHS)" "♪♪" "(SIGHS HEAVILY)" "ALICE:" "Jess, when I was growing up, I didn't really have many friends." "And when I left for college, my mom was worried about me." "And so was I." "But then we met, and the first night we went out, you didn't introduce me to people as your roommate, you introduced me as your friend." "And I knew everything was gonna be okay." "When I went homeKiwi, okay?" "All my best friends do." " Hey." " ALICE:" "Hi." " Can I get you a drink?" " Oh." "Um..." "No." "'Cause I'm on a date with someone else, so..." " Hey." " TOBEY:" "Hot." "You're a hot guy." "Cool." " Here you go." " Oh." "(GASPS) Oh, my God." "Has anyone ever told you how beautiful your feet are?" "No one's ever said that to me before." "You should've been told that a million times." "BOTH:" "Do you want to..." " Fuck?" " Fuck?" "Hey." "Keep it moving." "We're a thing." "Love wins." "What'd you just say?" "I don't know." "I mean, who knows if it will work out?" "And I don't know how you're gonna get to New York." "I guess hitchhike, but..." "I


about finding common ground. I tried to do this with people who saw accessible health care as not only expensive, but a moral threat. Still, it does not serve We the People to be fighting each other over crumbs when concentration of wealth and power allow a few to walk off with the whole cake.

Equal opportunity does not sprinkle down from an Invisible Hand. We have to defend the right to a basic, decent public life from private profiteers. Like pulling weeds, it never ends.

Cool stuff you see driving around Greater Providence. This train station behind a pharmacy parking lot has granite lions holding chains and shields with a heraldic ‘P’. Public architecture isn’t what it was before the two world wars, for a lot of reasons.

Will theNociceptive blink reflex and pain-related evoked potentials in hypnic headache.
Central facilitation of trigeminal pain processing and deficient habituation was observed in different headache and facial pain disorders. This overactivation seems to be primarily associated with chronic pain states. To investigate the function of the trigeminal nociceptive system in patients with hypnic headache (HH). Fifteen HH patients according International Classification of Headache Disorders II criteria and 15 age- and gender-matched healthy controls were investigated using the nociceptive blink reflex (nBR) and trigeminal pain-related evoked potentials (PREP). nBR and PREP responses showed no significant differences comparing HH patients and healthy controls. Moreover, no habituation deficit was detected in HH patients. Central facilitation and change in habituation do not seem to be a crucial part in the pathophysiology of HH despite


them to make judicious use of the items as it will help them in accessing the internet. She also commended President Jammeh for always encouraging the security personnel.

For his part, Professor Muhammadou Kah, the vice chancellor of the UTG, on behalf of the UTG community expressed sincere appreciation to their chancellor for the move. He described the donation as timely, saying that one cannot succeed today without being part of the digital future. "So these are very important gifts and they are very symbolic and I think we should all take information and communication very seriously in everything that we do and all aspects of life. So once again, we thank our chancellor for the gesture," he added.

Justice Wowo on behalf of Judiciary also described the gift asby β-adrenergic receptor antagonism in the ABA contexts, but is improved during extinction learning in the AAA context, suggests that it is not learning *per se*, but rather attention to the salient elements of the experience that is modulated by β-adrenergic receptors during extinction.

Although many studies have addressed the role of noradrenaline and β-adrenergic receptors in extinction of aversive experience (Cain et al., [@B13]), little is known about its role in extinction of appetitive memory (Mueller and Cahill, [@B60]), as was the focus of the current study. A role for noradrenaline in both memory consolidation has been reported (Quirarte et al., [@B67]; Roozendaal et al., [@B72]). Furthermore, noradrenaline is involved in fear extinction consolidation processes (Ouyang and Thomas, [@B62]; but see also: Lonsdorf et al., [@B47]). In the


is released from afferent fibers that originated in the locus coeruleus, the firing of which increases in response to novelty (Sara, [@B77]), and a variety of behaviorally relevant stimuli such as unexpected events, threats, reward or fear (Sara and Bouret, [@B74]). The degree of activity of the locus coeruleus is graded according to the saliency of the experience, whereby the slow tonic changes in firing rates that accompany fluctuations in arousal state, can rapidly change into burst firing upon exposure to noxious stimuli, for example (Valentino and Van Bockstaele, [@B88]). The locus coeruleus also exhibits a very specific activity profile in response to conditioned stimuli, whereby firing can become persistent and intensify if a stimulus is followed by a salient event (Aston-Jones et al., [@B6]; Sara et al.,4 (AAA paradigm), and when applied prior to re-exposure to the (unrewarded) "A" context on day 5 (ABA paradigm), suggesting that the robustness of this effect was not compromised by the context-dependent extinction event on day 4 in the "ABA" paradigm. We did not see an effect in extinction in the "A" context on day 5, when propranolol was given prior to extinction learning in context "B" on day 4, however. We propose that this is because propranolol is rapidly metabolized from the animals' system (Bargar et al., [@B8]; Baughman et al., [@B9]) and few or no β-adrenergic receptors remained under the influence of the antagonist when behavior was tested 24 h after the antagonist had been applied. Taken together, our data suggest that β-adrenergic receptor activation is


under the experimental conditions of the present study). In contrast, under conditions where no context change accompanied extinction learning, arousal levels can be expected to be comparatively lower, and learning under these conditions was tightly dependent on noradrenaline acting on β-adrenergic receptors. This possibility is supported by observations that depletion of noradrenaline impairs extinction learning of appetitive behavior (Mason and Iversen, [@B53], [@B54]; Mason, [@B55]; McGaugh, [@B56]). It may also be the case that a more intense NA release was stimulated by the context change that was not overcome by the antagonist dose used. However, this seems less likely, because treatment of an animal cohort prior to re-exposure to the "A" context, following successful extinction learning in the "B" context, failed to prevent renewal but significantly prevented subsequentre-extinction of the behavior learned in the "A" context.

It was striking that following inhibition of extinction in day 4 in the AAA context (following prior treatment with propranolol), renewal behavior occurred in the "A" context on day 5. We believe this effect adds support to our interpretation that β-adrenergic receptor antagonism affected attention but not learning *per se*. If learning had been impaired by the antagonist, a further, at least initial, suppression of extinction would have been expected on day 5: the animals had not learned (on day 4) that the "A" context can no longer be associated with a reward and thus, do not persevere to search for a reward in this context. Our animals showed renewal behavior, however, that refutes this possibility. If attention, *and not*,


*path*~1,8,14~ contains three fetal R peak candidates (*p*~1~, *p*~8~, *p*~14~).

A fetal R peak candidate is composed of a local minimum (Q-peak candidate), a local maximum (R-peak candidate) and a local minimum (S-peak candidate). As shown in [Fig 5](#pone.0223057.g005){ref-type="fig"}, three features of the single FQRS candidate are collected, namely the ratio of RS amplitude to RS distance *R*~*RS*~ (*R*~*RS*~ = *A*~*RS*~/*D*~*RS*~), amplitude of RS (*A*~*RS*~), the ratio of QR amplitude to QR distance *R*~*QR*~ (*R*~*QR*~ = *A*~*QR*~/*D*~*QR*~).

![The feature representation of FQRS.\
Each FQRS is composed of a local minimum (Q-peak candidate), a local maximum (R-peak candidate) and a local minimum (S-peak candidate).](pone.0223057.g005){#pone.0223057.g005}

By analyzing the path-wise representation of FQRS candidates in the tree, three regular patterns of the inter-QRS correlation can be noted.

-   In this work, we use theThe abdominal and direct fetal electrocardiogram database (ADFECGDB) contains five records collected from five pregnant women. Each record has 4 abdominal channels and one scalp ECG. The signal lasts for 5 min and is sampled at *f*~*s*~ = 1 kHz. The reference FQRS annotation derived from the scalp ECG is available \[[@pone.0223057.ref039]\].

-   Set A of 2013 PhysioNet/Computing in cardiology challenge database (PCDB) consists of 75 one-minute abdominal records. Data is sampled at *f*~*s*~ = 1 kHz. Each record contains four abdominal channels and the FQRS reference is available. To date, this database is the largest publicly available dataset \[[@pone.0223057.ref040]\].

As indicated in \[[@pone.0223057.ref019]\], seven AECG records (a33, a38, a47, a52, a54, a71 and a74) are discarded from the PCDB because of inaccurate reference annotations. In addition, the


given by $$SE = \frac{TP}{TP + FN}$$ $$PPV = \frac{TP}{TP + FP}$$ $$F_{1} = 2 \times \frac{SE \times PPV}{SE + PPV} = \frac{2 \times TP}{2 \times TP + FN + FP}$$ where TP corresponds to the number of true positives. As mentioned earlier, the FP and FN correspond to the number of false positive (falsely detected non-FQRS peaks) and false negative (missed FQRS detections), respectively.

Results {#sec013}
=======

In this study, the real AECG records from the PCDB and ADFECGDB are collected to evaluate the efficiency of the proposed method. Results of the proposed method on PCDB are shown in Tables [1](#pone.0223057.t001){ref-type="table"} and [2](#pone.0223057.t002){ref-type="table"}. Results of the proposed method on ADFECGDB are shown in [Table 3](#pone.0223057.t003){ref-type="table"}. In order to obtain the overall distribution of the metrics, the results on these twothe accurate location of the MQRS for MECG elimination. Otherwise, the MQRS waveform can not be sliced and aligned. It should be noted that obtaining the location of the MQRS is not always easy. As shown in [Fig 11](#pone.0223057.g011){ref-type="fig"}, it is difficult to access the location of the MQRS when the FECG and MECG amplitudes are comparable. Consequently, the performance in MECG elimination is reduced, and a reliable FHR measurement can not be obtained. In the proposed QRStree, there is no need for such prior information. Such that the FHR measurement can be achieved directly from the abdominal channel without eliminating the MECG waveform, so the proposed QRStree avoids the problems related to MECG elimination such as MQRS slicing and alignment.

![Examples of results with different methods when the


Back-to-Back

Heber Springs’ track and field dynasty continues to blossom into one of the most recognized in all of Arkansas, now having won five of the past six state titles in cross-country, indoor track and outdoor track. On Thursday, the Panthers capped back-to-back outdoor state titles in dramatic fashion on the hom...

Comment

By Will Gilbert/Sports Editor

The Sun-Times - Heber Springs, AR

By Will Gilbert/Sports Editor

Posted May. 10, 2012 at 12:01 AM
Updated Jun 29, 2012 at 11:28 AM

By Will Gilbert/Sports Editor

Posted May 10, 2012 at 12:01 AM
Updated Jun 29, 2012 at 11:28 AM

Nashville, Ark.

Heber Springs’ track and field dynasty continues to blossom into one of the most recognized in all of Arkansas, now having won five of the past six state titles in cross-country, indoor track and outdoor track.

On Thursday, the Panthersahead by 1 ½ points, Cresswell said his confidence was high. “I was pretty confident my four boys could beat their four boys. After the 800, we got up there close and then Jordan Peterson wins the 200. He is going to college to run the 400 but he won the 100 and 200, so that is pretty cool.” Peterson took 6th in the 400 (52.71).

The Panthers lose the senior leadership of Sanders, Peterson, Hood and Leonard but return Ligon, Schmidt, Ballard, Powell, Garcia and several other contributors, including Ethan Bly, who was hampered by a lingering hamstring injury in Thursday’s meet. Despite the injury, which knocked him out of the 100, 200 and 4 x 400 relay race, Bly still managed to place 5th in the long


Q:

What does this line of code mean (Bitwise Operator)

#define LODWORD(x) (*((unsigned int*)&(x)))

I'm translating C code to python and can't quite get this. If anyone can explain how to read this or what it means it'd be greatly appreciated.

A:

&(x)                  // get address of `x` as a pointer to whatever x is
(unsigned int*)(...)  // cast it to a pointer to `unsigned int`
*(...)                // then read that address' contents as if it was `unsigned int`

I'd use union if really needed, and only if I knew the CPU architecture, otherwise this is very very unsafe :P

A:

It's a macro forgetting the lower DWORD ( 32bits ) of a 64 bit variable, there's most likely an associated HIDWORD macro as well to get the higher 32 bits. Other comments have pointed out some flaws with the macro, but it's a fairly common idiom for accomplishing this.
Some equivalent Python code might be:
def LODWORD(x):
    return x & 0xFFFFFFFF


tea and methods of making them, including discussion of teabags, teapots, kettles and mugs.
Some Biscuits
The main part of the book, includes the technical definitions of all sorts of biscuits from the simple Rich Tea to the complex such as the Penguin, with advice on storage, dunking and enjoyment.  These are mostly British, with a final section on foreign ones which have entered the UK market such as Tim Tam or Choco Leibniz.  A Venn diagram shows the distinctions and overlaps between the categories biscuit, cake, bread, crackers, chocolate biscuits and chocolate bars.
A Little Bit of Cake
Covers Jaffa Cake, wedding cake, fairy cakes, packet cakes, ginger cake and Battenberg, with discussion of icing and glacé cherries.
And a Sit Down
Sitting down in a comfy chair is advised, butfor maintenance or detoxification treatment in accordance with this paragraph unless, before the expiration of that 3-year period, the State enacts a law prohibiting a practitioner from dispensing such drugs or combinations of drug.[1]

(J)

(i)This paragraph takes effect on the date referred to in subparagraph (I), and remains in effect thereafter.

(ii)For purposes relating to clause (iii), the Secretary and the Attorney General may, during the 3-year period beginning on December 29, 2006, make determinations in accordance with the following:

(I)The Secretary may make a determination of whether treatments provided under waivers under subparagraph (A) have been effective forms of maintenance treatment and detoxification treatment in clinical settings; may make a determination of whether such waivers have significantly increased (relative to the beginning of such period) the availability of maintenance treatment


which allows ALL her nutrition to be dedicated to the developing kids. Pushing a doe to do both will eventually reduce production, potentially damage the mammary system and shorten the long-term productivity and health of the doe herself.

So you ask…..how do you get enough milk to meet the demand as it continues to grow? There isn’t enough time to milk 50 or 100 goats twice a day and make products too!

Every business has to define its own success. We chose to be “Artisan” producers, meaning production in smaller batches to control quality and consistency without becoming factory “automated”, we stay true to “handmade”. It is who we are. We will never be a Dove or a Dial in terms of production. Big isn’t always better.

So, rather than increaseloaded the next day on the day shift, prior to blasting, which usually occurred about 2:30 p.m. after the day shift ended.

On the day of the accident, the production blast on the 20 ledge consisted of 2 rows of 9 blast holes drilled 67 feet deep on a 10-foot by 10-foot pattern. The blast included 2,500 pounds of prilled ammonium nitrate – fuel oil mixture (ANFO) and 35 cases of plastic wrapped slurry. Each blast hole was primed with a single primer. The blast holes were provided with 4-5 feet of stemming material.

A lead line of shock tube was run from the blast site to a location above the bench and about 300 feet behind it. The shock tube was initiated with a firing gun. The blast resulted


mask type */

	MAIL_SORT_END		= 0x0000 /* ends sort program */
};

enum mail_fetch_field {
	MAIL_FETCH_FLAGS		= 0x00000001,
	MAIL_FETCH_MESSAGE_PARTS	= 0x00000002,

	MAIL_FETCH_STREAM_HEADER	= 0x00000004,
	MAIL_FETCH_STREAM_BODY		= 0x00000008,

	MAIL_FETCH_DATE			= 0x00000010,
	MAIL_FETCH_RECEIVED_DATE	= 0x00000020,
	MAIL_FETCH_SAVE_DATE		= 0x00000040,
	MAIL_FETCH_PHYSICAL_SIZE	= 0x00000080,
	MAIL_FETCH_VIRTUAL_SIZE		= 0x00000100,

	/* Set has_nuls / has_no_nuls fields */
	MAIL_FETCH_NUL_STATE		= 0x00000200,

	MAIL_FETCH_STREAM_BINARY	= 0x00000400,

	/* specials: */
	MAIL_FETCH_IMAP_BODY		= 0x00001000,
	MAIL_FETCH_IMAP_BODYSTRUCTURE	= 0x00002000,
	MAIL_FETCH_IMAP_ENVELOPE	= 0x00004000,
	MAIL_FETCH_FROM_ENVELOPE	= 0x00008000,
	MAIL_FETCH_HEADER_MD5		= 0x00010000,
	MAIL_FETCH_STORAGE_ID		= 0x00020000,
	MAIL_FETCH_UIDL_BACKEND		= 0x00040000,
	MAIL_FETCH_MAILBOX_NAME		= 0x00080000,
	MAIL_FETCH_SEARCH_RELEVANCY	= 0x00100000,
	MAIL_FETCH_GUID			= 0x00200000,
	MAIL_FETCH_POP3_ORDER		= 0x00400000,
	MAIL_FETCH_REFCOUNT		= 0x00800000,
	MAIL_FETCH_BODY_SNIPPET		= 0x01000000,
	MAIL_FETCH_REFCOUNT_ID		= 0x02000000,
};

enum mailbox_transaction_flags {
	/* Hide changes done in this transaction from next view sync */
	MAILBOX_TRANSACTION_FLAG_HIDE		= 0x01,
	/* External transaction. Should be used for copying and appends,
	   but nothing else. */
	MAILBOX_TRANSACTION_FLAG_EXTERNAL	= 0x02,
	/* Always assign UIDs to messages when saving/copying. Normally this
	   is done only if it can be done easily. */
	MAILBOX_TRANSACTION_FLAG_ASSIGN_UIDS	= 0x04,
	/* Refresh the index so lookups return latest flags/modseqs */
	MAILBOX_TRANSACTION_FLAG_REFRESH	= 0x08,
	/* Don't update caching decisions no matter what we do in this
	   transaction (useful for e.g. precaching) */
	MAILBOX_TRANSACTION_FLAG_NO_CACHE_DEC	= 0x10,
	/* Sync transaction    struct mail_storage **storage_r,
			     const char **error_r) ATTR_NULL(2);
void mail_storage_unref(struct mail_storage **storage);

/* Returns the mail storage settings. */
const struct mail_storage_settings *
mail_storage_get_settings(struct mail_storage *storage) ATTR_PURE;
struct mail_user *mail_storage_get_user(struct mail_storage *storage) ATTR_PURE;

/* Set storage callback functions to use. */
void mail_storage_set_callbacks(struct mail_storage *storage,
				struct mail_storage_callbacks *callbacks,
				void *context) ATTR_NULL(3);

/* Purge storage's mailboxes (freeing disk space from expunged mails),
   if supported by the storage. Otherwise just a no-op. */
int mail_storage_purge(struct mail_storage *storage);

/* Returns the error message of last occurred error. */
const char * ATTR_NOWARN_UNUSED_RESULT
mail_storage_get_last_error(struct mail_storage *storage,
			    enum mail_error *error_r) ATTR_NULL(2);
/* Wrapper for mail_storage_get_last_error(); */
const char * ATTR_NOWARN_UNUSED_RESULT
mailbox_get_last_error(struct mailbox *box, enum mail_error *error_r)
	ATTR_NULL(2);
/* Wrapper for mail_storage_get_last_error(); */
enum mail_error mailbox_get_last_mail_error(struct mailbox *box);

const char * ATTR_NOWARN_UNUSED_RESULT
mail_storage_get_last_internal_error(struct mail_storage *storage,
				     enum mail_error *error_r) ATTR_NULL(2);
/* Wrapper


If this function isn't called explicitly, it's also called
   internally by lib-storage when necessary. */
int mailbox_open(struct mailbox *box);
/* Open mailbox as read-only using the given stream as input. */
int mailbox_open_stream(struct mailbox *box, struct istream *input);
/* Close mailbox. Same as if mailbox was freed and re-allocated. */
void mailbox_close(struct mailbox *box);
/* Close and free the mailbox. */
void mailbox_free(struct mailbox **box);

/* Returns TRUE if box1 points to the same mailbox as ns2/vname2. */
bool mailbox_equals(const struct mailbox *box1,
		    const struct mail_namespace *ns2,
		    const char *vname2) ATTR_PURE;
/* Returns TRUE if the mailbox is user's INBOX or another user's shared INBOX */
bool mailbox_is_any_inbox(struct mailbox *box);

/* Returns TRUE if the mailbox has the specified special use flag assigned. */
bool mailbox_has_special_use(struct mailbox *box, const char *special_use);

/* Change mailbox_verify_create_name() modseq is larger than max_modseq. Save those messages' sequences to the
   given array. */
void mailbox_transaction_set_max_modseq(struct mailbox_transaction_context *t,
					uint64_t max_modseq,
					ARRAY_TYPE(seq_range) *seqs);

struct mailbox *
mailbox_transaction_get_mailbox(const struct mailbox_transaction_context *t)
	ATTR_PURE;

/* Convert uid range to sequence range. */
void mailbox_get_seq_range(struct mailbox *box, uint32_t uid1, uint32_t uid2,
			   uint32_t *seq1_r, uint32_t *seq2_r);
/* Convert sequence range to uid range. If sequences contain
   (uint32_t)-1 to specify "*", they're preserved. */
void mailbox_get_uid_range(struct mailbox *box,
			   const ARRAY_TYPE(seq_range) *seqs,
			   ARRAY_TYPE(seq_range) *uids);
/* Get list of messages' that have been expunged after prev_modseq and that
   exist in uids_filter range. UIDs that have been expunged after the last
   mailbox sync aren't returned. Returns TRUE if ok, FALSE if modseq is lower
   than we can check for (but expunged_uids is


Introduction {#sec1-1}
============

Specific learning disability (SpLD) is a group of neurodevelopmental disorders which manifest in childhood as persistent difficulties in learning to efficiently read ("dyslexia" or "SpLD~1~"), write ("dysgraphia" or "SpLD~2~"), and/or perform mathematical calculations ("dyscalculia" or "SpLD~3~"), despite normal intelligence, conventional schooling, intact hearing and vision, and adequate motivation and sociocultural opportunity.\[[@ref1]\] Up to 5%--10% of "seemingly normal" school children have this hidden disability.\[[@ref1]\] Dyslexia affects 80% of all those identified as learning-disabled.\[[@ref1]\] The precise etiology of SpLD remains controversial but it is believed to be a result of functional problem with brain "wiring" rather than an anatomic problem and is genetically inherited.\[[@ref2]\]

Brain single-photon emission computed tomography (SPECT) is a well-established and reliable method to assess brain function through measurement of regional cerebral blood flow (rCBF).\[[@ref3]\] We conductedmice (Callahan et al. [@CR16]; Hirata-Fukae et al. [@CR69]; Wang et al. [@CR165]). Humanised mouse models have been used to dig deeper into mechanism; for example, pathological differences have been attributed to female-specific age-related increases in synaptic zinc, thought to contribute towards the aggregation of amyloid beta (Lee et al. [@CR87]). Additionally, stress, which as discussed below acts as an environmental risk factor for AD, has been shown to drive marked female-specific increases in amyloid pathology in the hippocampus, associated with increased levels of in APP and BACE1 (cleaves APP to produce amyloid beta), in an AD mouse model (Devi et al. [@CR29]). Overall, these marked pathological and mechanistic differences between the sexes suggest that AD treatments may need to be tailored to gender; backed up by a


behaviours, and are not simply small humans.

One key area in which humanised mice can tell us about the effects on environment lies in the study of weight, metabolism, and diet. Weight is an important trait in all human neurodegenerative disorders. Alterations in weight reflect changes in whole-body metabolism induced by disease (Kitamura et al. [@CR80]; Mariosa et al. [@CR103]; Nordestgaard et al. [@CR111]; Singh-Manoux et al. [@CR145]) and body weight alterations (i.e. weight loss or weight gain) are common comorbidities found in neurodegenerative disease (Djousse et al. [@CR33]; Emmerzaal et al. [@CR37]; Hu et al. [@CR71]; van der Burg et al. [@CR160]; Wills et al. [@CR172]). It is therefore not surprising that obesity and type II diabetes are risk factors for AD (Singh-Manoux et al. [@CR145]). Conversely, higherrisk, exercise in older age in patients should be viewed independently. In the context of precision medicine, it is possible that particular exercise regimes may be beneficial in some patients, but we need considerably more studies of age effects, genetics, exercise regime, etc. to draw conclusions. However, this area is vitally important, because exercise is a relatively straight-forward and cheap treatment that does not require patient hospitalisation.

Stochastic factors {#Sec13}
------------------

A recent study showed that random somatic mutation in the brain contributes to development of sporadic AD, through the creation of multiple reverse-transcribed copies of *APP* reinserted into the genomes of individual neurons, as discovered in human brain samples and a humanised AD mouse, (J20 transgenic animals, which overexpresses human APP with 2 AD mutations) (Lee et al. [@CR90]). Thus,


Shin et al. [@CR144]). Such an approach has been validated in humanised genetic mouse models of HD (Monteys et al. [@CR106]). However, this is not currently possible for the majority of AD, PD, and ALS patients who are 'sporadic' cases, as they do not carry known monogenic disease mutations.

Ultimately, early intervention or indeed prevention is the ideal therapeutic scenario. Humanised mouse models are proving their worth in understanding early neurodegenerative disease mechanisms, but the clinic needs to identify when these mechanisms have taken hold to inform when to begin therapies for individual patients and to identify disease onset as early as possible---and this means biomarkers. Biomarkers can also be used for stratification purposes to better understand disease diversity and how this might apply to treatment efficacy. The discoverytreatments in clinical trials.

Equally, for precision medicine studies, there is much to be learnt from the mouse studies as Lloyd and colleagues point out (Lloyd et al. [@CR97]): the kind of large-scale, well-networked, high-throughput analysis that is essential for precision medicine (Berlin et al. [@CR11]), is relatively routine (at least on a smaller scale) for the mouse community. Thus, we can use this experience to contribute to discussions about data management, accessibility, standardisation of phenotyping, etc. This also includes identification and analysis of critical metadata. Perhaps, the only area where the mouse and in particular humanised mouse models cannot contribute is in the issue of privacy and informed consent.

Equally, human diversity clearly highlights how we limit our understanding of neurodegeneration by working on single inbred lines, and the


easily be achieved in genetic mouse models or in human cells in vitro. Combining these systems can offer even more powerful models to study human neurodegeneration in vivo, in cell autonomous and non-cell-autonomous contexts (Espuny-Camacho et al. [@CR39]), and also provides excellent preclinical models to test therapeutics such as CRT.

If precision medicine is based on reviewing all the evidence to choose the optimal treatment for patients, then mouse studies must be included in this evidence. And of course, this is not only for treatment, but also for both prevention and diagnosis.

Box 1. neurodegenerative diseases referred to in the text {#Sec16}
---------------------------------------------------------

*Alzheimer\'s disease, AD* AD is the most common form of dementia, accounting for \~ 2/3 of people with dementia. 95% of those affected are over 65 years of age. Extracellular amyloid plaquesAfter their performance in St. Louis Monday night for The Smokers Club Tour, Ab-Soul, Joey Badas$$, and a few members of the Pro Era crew were arrested.

No official word on what the arrests were for, but itâs presumably marijuana related. Funny enough, it appears as if Joey doesnât know what heâs hand cuffed for either. With the news hitting Instagram, Joey is seen in the clip below hysterically laughing as he asks the cop:

âHave you figured out why Iâm in these handcuffs? Have you figured it out? Yo, they don't know why I'm in these handcuffs.â

Check it out below. Weâll have more details on this story when it comes available.

[UPDATE: Details On Arrest Emerge, Joey Bada$$ & Ab-Soul Were Released]

Last night footage circulated of Ab-Soul and Joey Bada$$


fucking up. [It was] basically profiling gone wrong. They saw the tour bus, passports, etcetera."

"The show is still on tonight in St. Louis," Statik added. "That was some typical police bullshit."Â

Check out our interview with Joey and Soulo while they were on the Smokers Club tour below.and apply decals, then apply Future over that...excellent finish). By far much better than the old candy-enamels we used as kids.
BUT...!....BEWARE. DO NOT follow the color swatches that are posted in the TS pdf files, nor those on this (and many others) website because they are way off. I needed an exact match of purple and this swatch was exactly the right color, however the actual paint dried much darker and almost had a purple red/maroon hue to it, so be very careful. If possible, search the internet for photos of the caps, as they are somewhat (but not always) closer.
Secondly, you must use these with excellent ventilation, or outdoors, and with a respirator mask. The fumes are horrific and carcinogenic.

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The potent antimalarial drug cyclosporin A preferentially destabilizes sphingomyelin-rich membranes.
Cyclosporin A (CsA) is a hydrophobic cyclic peptide produced by a fungus. CsA is widely used as an immunosuppressive agent to inhibit the rejection of transplanted organs. CsA also exhibits an antiparasitic activity against Plasmodium, the microorganism responsible for malaria disease. This antimalarial activity is not completely understood yet. In this study, we have used Langmuir monolayers and atomic force microscopy to investigate the interaction of CsA with different lipids: phosphatidylcholines with different molecular packing, cholesterol, and sphingomyelin. We have shown that CsA inserts in all kinds of lipid monolayers but it has a marked preference for sphingomyelin monolayers. This preferential insertion of CsA within sphingomyelin-enriched membranes could explain the antimalarial activity of CsA. Indeed, the parasites need to\\
  0 & C_{23}   & S_{23}  \\
 0 & -S_{23}  & C_{23}
\end{array}
\right)
\left(
\begin{array}{ccc}
 C_{13} & 0  & S_{13} e^{-i\delta_{CP}}  \\
 0 & 1  & 0  \\
 - S_{13} e^{i \delta_{CP}} & 0  & C_{13}
\end{array}
\right)
\left(
\begin{array}{ccc}
 C_{12} & S_{12}  & 0  \\
 - S_{12} & C_{12}  & 0  \\
0  & 0  & 1
\end{array}
\right)$$ where $C_{ij} = \cos \theta_{ij}$, $S_{ij} = \sin \theta_{ij}$, and $\delta_{CP}$ is the CP-violating phase. Note that although the CP-violating phase multiplies $S_{13}$ in Eq. (\[1\]), there is nothing special about this choice; one could have placed $\delta$ elsewhere in the mixing matrix. In fact the combination $$\label{2}
P( \bar{\nu}_{\mu} \rightarrow \bar{\nu}_e) - P( \nu_{\mu} \rightarrow