barrier dysfunction \[[@B35], [@B36]\]. Many studies have found that traditional Chinese medicine could reduce intestinal inflammation \[[@B37], [@B38]\]. Alabi QK reported that polyphenol-rich extract of Ocimum gratissimum leaves ameliorates colitis via attenuating colonic mucosa injury and regulating proinflammatory cytokines production and oxidative stress \[[@B39]\]. Our study suggested that RAD drug-containing serum significantly decreased TNF-*α* and IL-3 levels of Caco-2 cells after ET stimulation, while blank serum did not have the anti-inflammatory effect. Therefore, the intestinal inflammatory response may contribute to intestinal injury, and RAD could relieve intestinal injury by inhibiting the inflammatory response of Caco-2 cells.

5. Conclusions {#sec5}
==============

In summary, we cultured Caco-2 cells as experimental subjects and found that ET induced the oxidative stress injury and inflammatory response of Caco-2 cells. In addition, we verified that RAD drug-containing serum alleviated ET-induced oxidativebecame startled, the suit says, and began to “move about in an apparent effort to get up.” Some officers said he also swung his arms around.

That prompted the four armed officers who had been standing over November to “swarm” him, as one officer described it, and grab his arms and legs to keep him restrained.

Officer Gruarin, “a competitive weightlifter,” soon began punching November in the face and head with multiple blows, the complaint says.


Swelling of Olympic gels.
The swelling equilibrium of Olympic gels, which are composed of entangled cyclic polymers, is studied by Monte Carlo simulations. In contrast to chemically cross-linked polymer networks, we observe that Olympic gels made of chains with a larger degree of polymerization, N, exhibit a smaller equilibrium swelling degree, Q ∝ N(-0.28)ϕ(0)(-0.72), at the same polymer volume fraction ϕ(0) at network preparation. This observation is explained by a desinterspersion (reorganization with release of nontrapped entanglements) process of overlapping nonconcatenated rings upon swelling.Union Rd.

·23 acres planted in June and July of 2002 and 2003

·Location – 35 miles from downtown Columbus on State Route 29, near intersections of State Route 161 and State Route56. Within 25 miles of Springfield, London, Urbana, Marysville, Bellefontaine and Sidney

·Soil – Warsaw, well drained and underlain with gravel

·Soil preparation – 3 tons per acre gypsum and 3 tons per acre composted chicken manure applied in the row and tilled in prior to formation of beds

·Weed Control – 2 quarts Surflan over the row after planting supplemented by hand spraying of Roundup


the devices are said to convert semiautomatic weapons into fully automatic ones, they also decrease accuracy and are less safe, the experts say.

An NRA spokeswoman did not immediately respond to a request for comment about the group’s shooting range in Fairfax, Virginia. Sources familiar with the range confirmed that bump stocks are banned there.

The NRA on Thursday further distanced itself from the devices, calling for additional regulation of bump fire stocks while also warning that more sweeping gun bans “will do nothing to prevent future attacks.”

The devices have escaped regulation from the Bureau of Alcohol, Tobacco, Firearms and Explosives after that agency issued a 2010 letter exempting them from oversight.

"Devices designed to allow semi-automatic rifles to function like fully-automatic rifles should be subject to additional regulations," the NRApetition for habeas in this court requesting that he be released on bail pending a final determination of the petition in the extradition proceeding. On April 12, 1977, after hearing arguments of counsel, we entered an order granting the petition for bail. We set bail in the amount of $5,000 with surety and directed that upon the furnishing of such bail Mr. Bailey be released from custody until further order of this court. Our order also provided that in the event of an *484 adverse decision for Mr. Bailey in the extradition proceeding, the Attorney General might move in this court for revocation of bail. See order of April 12, 1977, supra. On the same day Mr. Bailey furnished bail and was thereupon released from custody.
On April 18,


why bail should not be revoked.
BEVILACQUA, C. J., did not participate.
NOTES
[1]  General Laws 1956, § 12-9-12 reads as follows:

"Appearance of prisoner before judge Application for habeas corpus.No person arrested upon such warrant shall be delivered over to the agent whom the executive authority demanding him shall have appointed to receive him unless he shall first be taken forthwith before a judge of a court of record in this state, who shall inform him of the demand made for his surrender and of the crime with which he is charged, and that he has the right to demand and procure legal counsel; and if the prisoner or his counsel shall state that he or they desire to test the legality of his arrest, the judge of such courtTechnology Strategy Board (part of BIS) on a high profile research project which aims to identify future technology and cyber security trends. These statements are forward looking and are intended to purely start a discussion around emerging/possible future trends. This is a great chance to be involved in an agenda setting piece of research. The findings will be released in the Spring at Infosec. We invite you to offer your thoughts…

The cloud/thin computing will fundamentally change the nature of cyber security…

The nature of cyber security threats will fundamentally change as the trend towards thin computing grows. Security updates can be managed instantly by the solution provider so every user has the latest security solution, the data leakage threat is reduced as data is stored centrally, systems can be


this re-centralization, but it is important to note that I do believe that if we look at what PaaS/SaaS offerings and VDI/Thin/Cloud computing offers, it makes us focus on protecting our information and building more survivable systems.

However, there’s a notable bifurcation occurring. Whilst the example above paints a picture of mass re-centralization, incredibly powerful mobile platforms are evolving. These platforms (such as the iPhone) employ a hybrid approach featuring both native/local on-device applications and storage of data combined with the potential of thin client capability and interaction with distributed Cloud computing services.*

These hyper-mobile and incredibly powerful platforms — and the requirements to secure them in this mixed-access environment — means that the efficiency gains on one hand are compromised by the need to once again secure diametrically-opposed computingthe Cloud Security Alliance’s guidelines. Participate in making the Automated Audit, Assertion, Assessment, and Assurance API (A6) a success so we can at least gain back some visibility and transparency which helps demonstrate compliance, since that’s how we’re measured. Ultimately, if you’re able, focus on risk assessment in helping to advise your constituent business customers on how to migrate to Cloud Computing safely.

There are TONS of things one can do in order to make up for the shortcomings of Cloud security today. The problem is, most of them erode the benefits of Cloud: agility, flexibility, cost savings, and dynamism. We need to make the business aware of these tradeoffs as well as our auditors because we’re stuck. We need the regulators and examiners to keep pace with technology


fast as possible.

* General maintenance. General web
site maintenance consists of link checks, broken images, form checks,
database checks etc depending on the type of functionality you have
on your web site.

The dynamic structure of web sites makes any change affect more
than one page, change something on one page and it usually have
effects on another page. Therefore it's important to make sure that
everything is working; broken links and images looks bad, it makes
your web site visitors annoyed and they might leave your site just
because of it.

All in all it means that you can continue your regular work without
bothering about the difficult parts of having a web site. We see
to it that it's up and running, adding the new content you want
and make the tedious tasks seem easy all the way through./*
 * Copyright 2019 Amazon.com, Inc. or its affiliates. All Rights Reserved.
 *
 *  Licensed under the Apache License, Version 2.0 (the "License").
 *  You may not use this file except in compliance with the License.
 *  A copy of the License is located at
 *
 *  http://www.apache.org/licenses/LICENSE-2.0
 *
 *  or in the "license" file accompanying this file. This file is distributed
 *  on an "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either
 *  express or implied. See the License for the specific language governing
 *  permissions and limitations under the License.
 */

package com.amazon.dlic.auth.ldap2;

import java.nio.file.Path;
import java.security.AccessController;
import java.security.PrivilegedActionException;
import java.security.PrivilegedExceptionAction;
import java.util.Collection;
import java.util.Collections;
import java.util.HashMap;
import java.util.HashSet;
import java.util.Iterator;
import java.util.List;
import java.util.Map;
import java.util.Set;

import javax.naming.InvalidNameException;
import javax.naming.ldap.LdapName;

import org.apache.logging.log4j.LogManager;
import org.apache.logging.log4j.Logger;
import org.elasticsearch.ElasticsearchSecurityException;
import org.elasticsearch.SpecialPermission;
import org.elasticsearch.common.Strings;
import org.elasticsearch.common.settings.Settings;
import org.ldaptive.Connection;
import org.ldaptive.ConnectionFactory;
import org.ldaptive.LdapAttribute;
import


        fillRoles0(user, optionalAuthCreds);
                    return null;
                }
            });
        } catch (PrivilegedActionException e) {
            if (e.getException() instanceof ElasticsearchSecurityException) {
                throw (ElasticsearchSecurityException) e.getException();
            } else if (e.getException() instanceof RuntimeException) {
      authenticatedUser =user.getName();
            originalUserName = user.getName();
        }

        final boolean rolesearchEnabled = settings.getAsBoolean(ConfigConstants.LDAP_AUTHZ_ROLESEARCH_ENABLED, true);

        if (log.isDebugEnabled()) {
            log.debug("Try to get roles for {}", authenticatedUser);
        }

        if (log.isTraceEnabled()) {
            log.trace("user class: {}", user.getClass());
            log.trace("authenticatedUser: {}", authenticatedUser);
            log.trace("originalUserName: {}", originalUserName);


   log.trace("Results for LDAP group search for " + escapedDn + " in base "
                                + roleSearchSettingsEntry.getKey() + ":\n" + rolesResult);
                    }

                    if (rolesResult != null && !rolesResult.isEmpty()) {
                        for (final Iterator<LdapEntry> iterator =      for (final LdapName nm : new HashSet<LdapName>(result)) {
                Set<Map.Entry<String, Settings>> nameRoleSearchBaseKeys = resultRoleSearchBaseKeys.get(nm);

                if (nameRoleSearchBaseKeys == null) {
                    log.error(
                            "Could not find roleSearchBaseKeys for " + nm + "; existing: " + resultRoleSearchBaseKeys);


by outright deception,” Horkins said toward the end of his hour-long decision.

“The harsh reality is that once a witness has been shown to be deceptive and manipulative in giving their evidence, that witness can no longer expect the court to consider them to be a trusted source of the truth.”

Horkins stressed the presumption of innocence in criminal cases is “not a favour or charity” and conviction requires proof “beyond reasonable doubt.”

Nonetheless his verdict incensed some groups who predicted it would deter women from coming forward about sexual abuse.

Ghomeshi, 48, who faces a separate sexual assault trial in June, showed little emotion at the verdict, but family members and supporters broke into broad smiles. He then left the courthouse without commenting, but his sister said the ordeal had beencategoriesCategoryNumber of postsVG/PG ratioHigh VG1562Max VGHigh VG100 % VG90/10 VG/PG80/20 VG/PGBalanced but high VG70075/25 VG/PG70/30 VG/PG60/40 VG/PGBalanced39350/50 VG/PGBalanced but high PG16640/60 VG/PG30/70 VG/PG25/75 VG/PGHigh PG12220/80 VG/PGHigh PGMax PG

Throat hit is the feeling of smoke hitting the back of the throat \[[@CR21]\]. E-cigarette users, who are former or even current traditional cigarette users, are more likely to prefer this feeling for satisfaction and sensation fulfillment \[[@CR21], [@CR22]\]. However, users who pick up smoking behavior by using e-cigarettes may be more likely to find the throat hit is less desirable or comfortable. The throat hit was the most common symptom inferred from the data we collected. Thus, we first studied the throat hit among e-cigarette users for our symptoms analysis. We used the phrase "throat hit" to identify posts that are


\[[@CR26], [@CR27]\]. The FDA has also deemed VG safe \[[@CR28]\], although no research has shown VG as a source of throat hit. Flavors could also be responsible for throat hit. For example, some posts in our dataset mentioned that menthol flavor could produce a feasible throat hit for former traditional cigarette users. A few other substances could also cause throat hit. For instance, some strawberry flavors were reported to be alcohol based, which could make the taste of e-juice really harsh and be considered as a sort of throat hit. In order to capture the general characteristics among each flavor category, we filtered posts with information of VG/PG, nicotine, and throat hit and then calculated the average value of each variable. Therefore, the relationship between throat hit andthan 15 mg. People usually reported negative feelings such as harsh, straining, and burning along with a cough. This might be related to VG/PG ratio, flavors, or nicotine level. Interestingly, cinnamon was considered by some users as the reason for the cough, while watermelon flavor was thought to be soothing and reduce the cough reaction while vaping.

Sinus symptom was another interesting point of discussion. Most sinus symptom reports were positive. People reported that vaping e-cigarettes would be helpful to open up and/or clear sinuses.

Symptoms in neurological systems were mainly about headaches. High PG and fruits or seasonings flavors were most commonly reported. Nicotine levels were primarily over 15 mg, which was really high \[[@CR30]--[@CR35]\]. Some people reported horrible headaches, while some believed vaping helped headaches. Fatigue was an interesting symptom


sophisticated algorithm. The symptoms, on the other hand, should be examined by clinical study to gain solid ground truth of the effect of using e-cigarette. Both of them are valuable research topics. Our study suggests that the e-juice components should be taken into consideration when these two type of research is conducted.

Finally, user demographic information should be considered to be included in the research of e-cigarette. Our finding only suggests some general relationships between symptoms and e-juice components. However, with the help of demographic information, we could figure out which sub-group of population are easily caught by certain symptoms. Then some specific regulation could be made to aim at these vulnerable people. While survey could be used to collect demographic information directly, some information techniques could be usedelse, and I was straining my throat so bad I was coughing up blood from the vaper, Not from coughing excessively just a Cough once or twice and not hard as if I was smoking a cigarette.2. I am new to vaping and decided to start with a vaporfi pro xl. For the most part it works fine except for the first 2--5 hits. They always taste really harsh, burnt, makes a lot of popping noises, and makes me cough quite a bit.Phlegm1. It just makes it more enjoyable and satisfies my sweet tooth. 50/50 is my go-to but I have yet to try a full VG mixture, as I have a slight PG allergy I think, where if I vape a 70/30 PG/VG for too long, my


sweet) sugar. It gave me a headache after a few drags.2. I find higher PG makes me vape less (due to the 'fuller vape' feeling from the increased throat hit), which in turn means less nicotine and less dehydration. Helped with my headaches.Sleep disorder1. I had made an vg mix with 5 g herb, and cinnamon cookies aroma, it was good but not so potent. It made me sleepy when I vape it, but now i use that to soak my herb into ago atomizer, and it gives a nice "cookie" taste :DTingle1. Straw-menth (Nippy Strawberry) by Bumblebee Eliquids...This menthol coats the tongue, makes it tingle, but does not travel much further than that. It compliments the strawberry perfectly without it overpowering the overall flavour of the juice. Totallyone up, it was suuuuper smooth and delicious, but over time it sort of waffled between smooth and rough. Not rough like throat hit or coughing, but a kind of zingy mouthfee,l like when you eat too many lemons raw or how your tongue feels the day after you burn it on your tea. I'm going to chalk this roughness up to me wicking poorly though. Overall a good vape. 7.5/10Teeth1. Next up is a true southern taste known as Raspas...this flavor features crisp, ripe strawberries with a splash of tangy watermelon and a mild coconut finish...but now you can enjoy the flavor without your teeth chattering! Both of these flavors are from our Artisan Series of e-liquid with a 30 % PG and 70 % VG base.2. It's a


an avid brusher, flosser and mouthwash user. I've never had a cavity before age 30 and suddenly my visit to the dentist last week revealed that I have 5 cavities!!! I always go to the dentist ... I've not changed my diet habits or sweets intake and I take care of my teeth. In the past year, the only difference is that I started vaping (I know I'm weird, but I've never smoked actual cigarettes). So I'm thinking that maybe the sweet juice is causing cavities. I asked my dentist, but he doesn't know a lot about vaping, but he thought maybe the sweet liquid could be a factor. I use a VP/PG mix from my local vape shop. It's usually a banana/vanilla flavor. I know this isthat he can drop into the mores of his age group and beyond that into the social milieu in which he will live out his life. He is not an end in himself.

Jurisprudence has come around to the same idea, holding more and more that human behavior is not a matter of personal responsibility as much as it is a reflection of the social forces working on the individual; the tendency is to lay on Society the blame for crimes committed by its members. This, too, is a tenet of sociology, the increasing popularity of which, and its elevation to a science, attest to the hold that collectivism has on our times. The scientist is no longer honored as a bold adventurer into the unknown, in search of


Cysteine-Modified Self-Assembling Peptides on Gold: The Role of the Head and Tail.
Molecular self-assembly consists of the spontaneous aggregation of molecules into a well-defined structure guided by noncovalent bonds. The self-assembly strategy is ubiquitous in nature and recently has been proposed as a nature-mimetic strategy in polymer science and biomaterial engineering. In this context, we aim at designing and testing innovative but simple chemical strategies to efficiently modify surfaces by exploiting minor modifications in the bioactive molecule functionalities, for example, introducing cysteine (Cys) as a terminal residue in self-assembling peptides (SAPs). In this work, we report the attenuated total reflection-Fourier transform infrared spectroscopy, synchrotron radiation-induced X-ray photoelectron spectroscopy, near-edge X-ray absorption fine structure spectroscopy, and time-of-flight secondary ion mass spectrometry investigation of self-assembled layers of oligopeptides anchored onto goldcomposed of oxidase-positive, non-motile, asaccharolytic, aerobic Gram-negative bacteria. Most species of *Moraxella* are fastidious, although growth can be enhanced by incubation in capnophilic conditions. Gram-stain morphology varies within the genus, with bacteria appearing as diplococci, coccobacilli or short rods. *Moraxella* spp. are part of the normal flora of the human respiratory and genital tracts, and are considered to have low pathogenic potential. The most common species causing infection in humans is *Moraxella catarrhalis*, which can cause otitis media in children and exacerbations of chronic obstructive pulmonary disease \[[@R1]\]. Other *Moraxella* species capable of causing rare infections include *Moraxella atlantae*, *M. canis*, *M. catarrhalis*, *M. lacunata*, *M. lincolnii*, *M. nonliquefaciens* and *M. osloensis*, which was separated from *M. nonliquefaciens* in 1967*. Moraxella* sp. rarely cause invasive disease and only


so it has some shape. I stamped the sentiment, added a Limeade brad underneath along with two punched flowers with brad centres. I popped up the Basic Gray circle over the larger yellow and pink punched circles. To complete the card front I just couldn't resist blinging up the parasol!

I stamped a parasol inside with a sentiment over the top - which I really should have done before gluing the two card base pieces together - mental note duly made!

Cards made using the largest sized Labels Framelits die are too wide to fit inside a regular envelope which gave me the opportunity to make a snazzy matching envelope using patterned paper. I cut paper measuring 8 1/2" square and using the diagonal scoring plate scored two sides at4 3/8" and two sides at 3 3/4". I layered a fancy label onto an oval and added punched flowers with brad centres so I have somewhere to write the recipients name.

Here's the card and envelope together - very bright and cheery I think!

I hope you'll join in with our sketch challenge at Inkspirational this week, I'd love to visit your blogs to see your wonderful creations! The other DT members will have made fab cards to inspire you so check them out before you go off to create!

Monday, 24 June 2013

I have two ladies, Angela and Janet, coming to my home this afternoon for a card class. Angela lives in my neighbourhood, just up the road from me, and for many years we've exchanged pleasantries when we've


5 1/4" square Blushing Bride card base. I inked the glass stamp with Blushing Bride ink so that I had pink bubbly and then I added Basic Gray ink to the glass with a marker pen. I fussy cut both glasses, popped them up and added jewels for the bubbles. I then punched some silver glitter hearts, glued a couple flat to the card and popped a couple up. I computer generated the sentiment using the Euphoria Script font and layered it onto a Basic Gray strip.

I cut a white panel for inside the card, stamped the sentiment and partial doilies at opposite corners and added more punched hearts. The envelope flap got punched hearts too!

I was pleased how this card came together and I just hope theon Whisper White CS. I stamped the sentiment, fussy cut the flowers and popped them up. A bright pop of Tangerine Tango was added with ribbon and a button to echo the colour in the patterned paper - and that's quite enough Tangerine Tango on a card for me! I added a punched butterfly with aqua nailheads and popped the tag up on the card.

For the second card I was inspired by this lovely card made by Wanda which is very clean and fresh. I came over all shabby and distressed though when I made my version! I wanted to extend the layered stamping to include the splodge and postmark and I thought some inky distressing was called for. I used Pale Plum CS for the A6 card


Voltage-gated sodium channels and the molecular pathogenesis of pain: a review.
Pain pathways begin with spinal sensory (dorsal root ganglion, DRG) neurons that produce nociceptive signals and convey them centrally. Following injury to the nervous system, DRG neurons can become hyperexcitable, generating spontaneous action potentials or abnormal high-frequency activity that contributes to chronic pain. Because the generation of action potentials in DRG neurons depends on voltage-gated sodium channels, an understanding of the expression and function of these channels in DRG neurons is important for an understanding of pain. Molecular studies have indicated that at least eight distinct voltage-gated sodium channels, sharing a common overall motif but encoded by different genes that endow them with different amino acid sequences, are present within the nervous system. The DRG neurons express sixultimately hope to become permanent residents of their host nation.

A protester is pictured at Portland International Airport in Oregon. President Trump was condemned for railing against refugees coming to the US from ‘shithole countries’ in Africa (Picture: AP)

The Los Angeles Times reports that the zero figure for October was partly because of bureaucratic reasons.

Hundreds of refugees who had been cleared for arrival were held up by the delayed signing of an order by Trump aimed at limiting refugee numbers to just 18,000 a year.

Ukrainian cadet jumps from a plane before crash kills 26 passengers

The president finally signed that order on Friday, with those refugees now expected to begin arriving in the US from Tuesday.

In 2016, the administration of then-President Barack Obama set the resettled refugee ceiling at 110,000


Epithelial cells derived from the ectoderm during embryonic development line the outer layer of the body and internal organs, serving an important barrier function. Unique properties of epithelial cells depend on their gene expression profile that is regulated by a set of epithelium-enriched transcription factor families including E26 transformation-specific (ETS), p63, activating protein-2 (AP2), and krüppel-like factors (KLFs).^[@i1552-5783-58-5-2785-b01][@i1552-5783-58-5-2785-b02][@i1552-5783-58-5-2785-b03]--[@i1552-5783-58-5-2785-b04]^ Disruption of epithelial gene expression pattern results in severe abnormalities including epithelial--mesenchymal transition (EMT), a process by which sedentary epithelial cells transition to more motile, invasive mesenchymal cells.^[@i1552-5783-58-5-2785-b05],[@i1552-5783-58-5-2785-b06]^ Epithelial cells undergoing EMT are transcriptionally reprogrammed to undergo morphologic and molecular changes toward a mesenchymal phenotype by SNAIL, TWIST, ZEB, and FOX transcription factor family members.^[@i1552-5783-58-5-2785-b07]^ At the cellular level, EMT is associated with increased proliferation and migration, elevated resistance toAll procedures were approved by the University of Pittsburgh Institutional Animal Care and Use Committee and conformed to the ARVO Statement for the Use of Animals in Ophthalmic and Vision Research.

Human Corneal Limbal Epithelial Cells {#s2b}
-------------------------------------

Human corneal limbal epithelial (HCLE) cells obtained from Ilene Gipson (Harvard University, Boston, MA, USA) were maintained as previously described.^[@i1552-5783-58-5-2785-b45]^ Briefly, HCLE cells were cultured in keratinocytes-serum free medium (KSFM) supplemented with calcium chloride (0.3 M), epidermal growth factor (0.2 ng/mL), and brain pituitary extract. To induce EMT, 70% confluent HCLE cells were treated with 10 ng/mL of TGF-β1 for 48 hours, following which they were imaged for morphologic changes and processed to evaluate KLF4 levels and EMT markers by quantitative PCR (qPCR), immunoblots, and immunofluorescent staining.

Antibodies {#s2c}
----------

Antibodies used in this study were


E-cadherin and β-catenin are normally tethered together at the epithelial cell membrane; loss of E-cadherin releases β-catenin into the cytoplasm and nucleus, which in turn promotes EMT; and the aberrant nuclear localization of β-catenin is often associated with CE neoplasia,^[@i1552-5783-58-5-2785-b50]^ we next examined whether β-catenin expression is altered in the *Klf4*^Δ/ΔCE^ CE. Immunoblots revealed that the expression of β-catenin is up-regulated by 2.5-fold in the *Klf4*^Δ/ΔCE^ compared with the WT ([Figs. 4](#i1552-5783-58-5-2785-f04){ref-type="fig"}A, [4](#i1552-5783-58-5-2785-f04){ref-type="fig"}B). Immunofluorescent stain confirmed elevated expression and the nuclear translocation of β-catenin in the *Klf4*^Δ/ΔCE^ cells ([Fig. 4](#i1552-5783-58-5-2785-f04){ref-type="fig"}C). Together with the up-regulation of vimentin and down-regulation of E-cadherin in the *Klf4*^Δ/ΔCE^ corneas, these results demonstrate that Klf4 is essential for maintenance of CE phenotype and that the absence of Klf4 leads to EMT.

![Increased expression and nuclearand survivin.^[@i1552-5783-58-5-2785-b07],[@i1552-5783-58-5-2785-b47],[@i1552-5783-58-5-2785-b49],[@i1552-5783-58-5-2785-b64]^ These changes are also consistent with a less differentiated status for *Klf4*^Δ/ΔCE^ cells with increased life span resulting in abnormal stacking of CE layers, and squamous metaplasia reported earlier.^[@i1552-5783-58-5-2785-b42]^

EMT is associated with elevated expression of a group of transcription factors including members of the Snail, Twist, and Zeb families.^[@i1552-5783-58-5-2785-b17],[@i1552-5783-58-5-2785-b65]^ Considering that the overexpression of each of these transcription factors can induce EMT on its own,^[@i1552-5783-58-5-2785-b60]^ their combined up-regulation provides strong evidence in support of EMT in the *Klf4*^Δ/ΔCE^ CE. Snail and Slug are both known to repress the expression of E-cadherin, whereas KLF4 activates it. Whether the down-regulation of E-cadherin observed in the *Klf4*^Δ/ΔCE^ cells is a direct outcome of the absence of Klf4 or caused indirectly by up-regulation of Snail and Slug remains to be


have declared null, void, and of no effect two contracts, dated April 25, 1922, and December 11, 1922, respectively, and two oil and gas leases to lands in the naval petroleum reserves in California, dated June 5, 1922, and December 11, 1922, respectively. The prayer of the bill is that these agreements and leases be canceled, for an accounting, and for general relief. The relief is sought upon two grounds: First, fraud in the making of the contracts and leases; and, second, lack of legal authority for their making.
The case has received the careful consideration that its importance demands, but existing circumstances, due to pressure and volume of work in the court, do not admit of the preparation of a detailed opinion upon every issue. The formal decisionof contractor on the Atlantic Coast, and provides, further, that any part of said fuel oil will be allocated to the Navy on 30 days' written notice and held for not more than 6 months in storage for the Navy at one cent per barrel per month storage charges until and unless such oil is purchased or released by the Navy, such allocation, however, shall not be maintained more than six months, and it provides, further, "that if and when such oil is purchased by the Navy, contractor shall be paid therefor at market prices from current available Navy funds, and no charge shall be made against the government under this section except for and on account of oil so set aside."
(7) Contractor agrees to furnish at such


points as the government shall designate a reasonable amount of crude oil products and storage facilities therefor similar to those agreed by this contract to be furnished at Pearl Harbor, T. H., when the royalty oils delivered by the government to the contractor shall have been sufficient to pay for the Pearl Harbor project pursuant to the contract of April 25, 1922, and also for the additional work and crude oil products in this contract agreed to be furnished.
(8) Gives the Navy the privilege of purchasing at 10 per cent. less than market price at tidewater any additional available fuel oil produced from government lands in the California Naval reserves which it might require above the amount which it is entitled to in exchange for its royalties, andoil reserves from the Navy to the Interior Department, and he appears to have at all times dominated the situation relative thereto; the record in this case indicating that Secretary Denby was passive, and even complacent, in the matter. In one of his early conferences with the Navy Council, Mr. Denby stated that he was going to transfer control of the reserves to Secretary Fall because he considered the reserves "dynamite." This was his attitude throughout all of the transactions involved in this case. His participation in the making and executing of the agreements in suit was perfunctory, passive, and formal. Secretary Fall and Admiral Robison were the real, active, and efficient agents of the government in the negotiations which resulted in the contracts and leases in controversy.


Department. But Denby informed him that their protest was too late, as the transfer had been agreed to by the President, Secretary Fall, and himself. Roosevelt, after consultations with Admiral Griffen, who at that time was in charge of the naval oil reserves as Chief of the Bureau of Engineering of the Navy Department, suggested to Secretary Denby a modification of the proposed order. Secretary Denby told Roosevelt that, if he could obtain Secretary Fall's approval to the change, it would be satisfactory to him. Roosevelt personally took the matter up with *53 Secretary Fall, and Fall immediately assented to his suggestion. This action by Secretary Fall seems to negative bad faith, but I believe that Secretary Fall considered Secretary Denby's passivity tantamount to relinquishment. The concurrent andpublic policy.
The defendants' answer denies generally and specifically any fraud or conspiracy in the making of the contracts or leases in suit, and avers that they were lawfully made and constitute binding agreements. A conspiracy is a combination of two or more persons to effect an illegal object as an end or means. It is not necessary that the joint purpose or intent of the actors be to commit a criminal or even an unlawful act. It is sufficient if their intent is to do or accomplish a lawful act by surreptitious or unlawful means. This is especially true when the object of the joint purpose of the actors is the formation or making of a public contract with an officer of the Government.
The conspiracy alleged in the


United States has uniformly enunciated the principle that in cases of conspiracy or agreement to defraud the United States the ultimate question is not whether the fraud practiced must have inflicted upon the government pecuniary loss, but that the injury is complete as far as the grievous wrong is concerned when the purpose and effect of the agreement or transaction is to defeat a lawful function of the government. Haas v. Henkel, 216 U. S. 462, 30 S. Ct. 249, 54 L. Ed. 569, 17 Ann. Cas. 1112.
It is true that no civil action lies for a conspiracy, unless there be an overt act that results in damage to plaintiff; but the rule announced by the Supreme Court of the United States in the above-cited and other casesoil reserves and the proposed Pearl Harbor project as early as December, 1921, and Mr. Doheny told Admiral Robison during this time that his company would bid on the Pearl Harbor project, and that its bid would be one that would not involve one cent of profit to him or to his company. Admiral Robison, in his enthusiasm over the possibility of accomplishing his desire to strengthen the national defense, told Secretary Fall of Mr. Doheny's promise. Secretary Fall, however, had previously seen and talked with Mr. Doheny regarding the plan of using royalty oil for tankage, and it is clear that Mr. Doheny was already favorable to the plan, and had told Secretary Fall that he would make a bid thereon and that his bid would be


the building and equipping of the Pearl Harbor reserve fuel station. By this coalescence of interest the two men worked to attain the same end, but through entirely different motives.
Secretary Fall and Mr. Doheny had been friends for 30 years. They had been associates in mining ventures in New Mexico in early days. An attachment had grown up between them that is experienced only by men who pioneered and prospected together in quest of fortune in the fastness of the mountains and deserts of the great West. They had been separated for some time. Fall had remained in New Mexico and had entered public life. Doheny had gone to California and had engaged in the oil industry. Fall had been unsuccessful in accumulating money. He was a prominent,but a poor, man. Doheny, on the other hand, had been prosperous and had become wealthy. While the strong friendship of the early days in New Mexico had extended over the years that had intervened, the two men had seen little of each other until Fall became Secretary of the Interior. The record in this case is silent as to any business or money transactions between these two men until Fall assumed the Cabinet office. In this official position, having much to do with oil-bearing public lands, naturally the early intimacy was revived and renewed, so that Secretary Fall and Mr. Doheny and their families saw much of one another during the summer and fall of 1921, frequently visiting at Washington, New York, and elsewhere. It is not


doing what he did relative to these contracts and leases. It is not probable. It has not been satisfactorily or sufficiently explained in this case.
The case, however, does not require the court to predicate its finding on this telling and decisive incident solely upon the time and amount of the money transfer. The manner in which it occurred and the conduct of the two men relative thereto arouse further suspicion, and indicate a consciousness of wrongdoing by them. On November 28, 1921, Mr. Doheny wrote Secretary Fall a letter which, in my opinion, substantiates the charge of the conspiracy alleged in the amended bill, and which undeniably discloses that the two men had been conferring and negotiating regarding the Pearl Harbor contract of April 25, 1922, and thatnothing if they do not indicate an understanding previously had, and, when read in connection with the final paragraph of the letter, show that it was contemplated and agreed between the two men that a contract would be arranged along the lines of the letter, and that the only matters remaining undetermined were the "details" of the plan. This was unquestionably Mr. Doheny's mind when he wrote the letter, and undoubtedly Secretary Fall's when he received it, because he immediately sent it to Admiral Robison with a covering letter, as follows:
                "November 29, 1921.
"My Dear Admiral: Mr. Cotter will wait upon you with data, etc., with relation to oil tanks and royalty oils


Senate investigating committee, in part as follows:
"Mr. Doheny: Well, I will tell you frankly now  I don't know whether this has any connection whatever with the investigation  but I expected that if the Senator did not sell or turn over that land that later on I might employ him in connection with our affairs in Mexico, with which he is very conversant, and I would pay him a salary large enough, of which he could pay about one-half to apply on the note, and pay it off in five or six years. And that was my expectation.
"The Chairman: You had that in mind at that time?
"Mr. Doheny: Yes, sir.
"The Chairman: If Mr. Fall does not enter your employ, do you ever expect to press him forin mind employing him and his repaying this note out of his employment?
"Mr. Doheny: Yes, sir.
"Senator Pittman: And he had talked to you about resigning from the job of Secretary of the Interior?
"Mr. Doheny: Yes, sir; but I did not know how soon he would retire, whether he would stay his term out or not. We never discussed the length of time that he would remain in the Interior Department."
This is another incident so indicative of improper influence as to characterize the public contracts in controversy as tainted with fraud, regardless of the intentions of Fall and Doheny with respect to this anticipated and contemplated future employment. The fact that it occurred during the negotiations of the contracts involved in this suit, when considered in connection with the


other facts and circumstances in proof, and particularly the $100,000 transaction, so taints and contaminates such contracts as to require a court of equity to set them aside.
The actual effect of the contract of April 25 and the valuable preferential right which it conferred upon the Pan-American Petroleum & Transport Company was to utterly destroy competition for any oil leases in naval reserve No. 1. It is true that for this concession to the Pan-American Petroleum & Transport Company the government saved approximately $500,000 in the Pearl Harbor project. But the destruction and prevention of competition in a public matter of such gigantic proportions as leases to more than 30,000 acres of proven oil-bearing land, which represent a potential profit to a lessee of $100,000,000, *68 cannot bejustified under the facts and circumstances shown by the evidence in this case.
It is contended by defendants that the contracts and leases in controversy were fairly obtained by competitive bidding. The evidence does not sustain this claim. Aside and apart from the question as to whether the contracts and leases in question could be lawfully made without competitive bidding, the manner in which the bidding upon the April 25 contract was conducted, as well as the way in which the agreements were negotiated and executed, manifests in my opinion a determined purpose on the part of Secretary Fall to favor the companies controlled by Mr. Doheny to the prejudice of other prospective, available, and actual bidders. There is official conduct and correspondence of Secretary Fall which indicates that


various oil companies and others who were asked to bid to indicate that the Interior Department intended to or would consider a proposition of a preferential right to lease the naval oil reserves; and no company other than the Pan-American Petroleum & Transport Company apparently considered that a proposal embodying such preferential right would be entertained by the Interior Department, or that such a proposition would be in accordance with the invitation to bid. No other company than the Pan-American Petroleum & Transport Company had information such as was referred to in the letter of November 28, 1921. Secretary Fall had never told any other officer of any other oil company that he would or expected to grant further leases to oil lands in connection with the Pearlof $100,000,000 from the contracts and leases in suit. If the various oil companies had known or realized what Mr. Doheny had been told by Secretary Fall, it is more than probable that less profit would have satisfied them, which would, of course, have correspondingly increased the value that the government would receive on account of the leases and contracts in question.
After the bids were opened on Saturday, April 15, 1922, at 12 o'clock noon, in the office of Assistant Secretary Finney of the Interior Department, they were turned over to Dr. Bain and Mr. A. W. Ambrose, Chief Technologist for the Bureau of Mines of the Interior Department; and on Monday, April 17, 1922, Mr. Ambrose filed a report and comparison of the bids with Acting Secretary


or disagreement between the contractors and the Navy or others. Mr. Dunn, who was to do the construction work at Pearl Harbor under subcontracts with the Pan-American Petroleum & Transport Company, insisted that the final arbiter should be the Secretary of the Interior. It was so decided. Admiral Robison consented to such decision, and thereupon the following letter was prepared and transmitted. It was received by Secretary Denby and approved by him, as will appear by his indorsement. The letter reads:
       "Department of the Interior.
            "Washington, May 5, 1922.
"The Secretary of the Navy  Dear Mr. Secretary: April 25, 1922, the Navy and Interior Departments entered into a contract *75 withthe first part of the contract mentioned above.
"The Chief of the Bureau of Yards and Docks, Navy Department, Admiral L. E. Gregory, is designated as the representative of the Secretary of the Interior in handling the second part of the contract as noted above. This involves, first, all technical matters in connection with the plans and specifications for storage, and which in its general phases can be most expeditiously handled in Washington; second, the supervision of construction work in the field at Pearl Harbor; and, third, the receiving of the oil at Pearl Harbor from the tankers and placing same in tank storage as it becomes available under this contract until such time as the completed plant shall be turned over to the government.
"The Secretary of the Interior


the April 25 contract should be immediately transformed from a contingent and inchoate right into a vested one, and his request was acceded to without delay by Secretary Fall.
This was another positive and unmistakable manifestation that the Pan-American Petroleum & Transport Company was less interested in the Pearl Harbor contract and the existing royalty oil from the reserves than with the immediate grant of further valuable leases in the reserves to themselves without competition and through favoritism and discrimination. The Pearl Harbor contract was of no value and of little interest to the Pan-American Petroleum & Transport Company without the preferential right. It was the preferential right that had real commercial value. It cannot be said with any degree of reasonable probability that Secretary Fall's approval of thishe wisely decided to let well enough alone as to the legality of the April 25 contract.
There are some other details in connection with the contract of April 25, 1922, and the lease of June 5, 1922, that are significant in the consideration of the first general contention of the plaintiff in this case, and they have been covered by the findings of fact and conclusions of law filed simultaneously with this opinion. Further mention herein I deem unnecessary.
We are therefore brought to a consideration of the contract and lease of December 11, 1922. I shall not review much of the record relative to the execution of these agreements. They are inextricably bound to the April 25th contract, and all of the agreements are component parts of a


and that in consideration of these undertakings the government would, under the preferential right to lease granted under the April 25 contract, immediately lease to the Pan-American Petroleum Company all of the unleased portions of naval reserve No. 1, excepting a certain area upon which no leases would be granted to any concern, and would authorize immediate extensive and general drilling thereon.
The agreement proposed was to continue for 15 years after the completion of the Pearl Harbor construction. It was in effect a complete surrender and transfer of approximately 30,000 acres of valuable proven oil land and its oil contents, estimated at from 75,000,000 to 250,000,000 barrels of oil, for 15 years at least. Some idea of the value of this concession, granted secretly, privately, and without aof the United States.
It has been previously noted that the only provision in the Leasing Act of 1920 as to the use and disposition of royalty oils accruing to the United States from leases made under said act was that the Secretary of the Interior, "except whenever in his judgment it is desirable to retain the same for the use of the United States," shall offer the royalty oil and gas for sale at public auction. In cases where no satisfactory bid was received, he then might readvertise such royalty oil and gas for sale, or might sell the same at private sale at not less than the market price, or he might accept the value thereof from the lessee. The Leasing Act further empowered the Secretary of


use of the Navy and the benefit of the United States. The Congress appropriated and set aside for the use of the Navy, not only the lands and their petroleum contents, but it also additionally appropriated and set *84 aside $500,000 in money, which it gave the Secretary of the Navy the right to use until July 1, 1922, in connection with his general power of administration and control of the reserves for the benefit of the United States. The grant of power, as well as the discretion to be exercised by the Secretary of the Navy in executing this grant under the Act of June 4, 1920, extends to all points and conditions connected with the naval reserve lands, and the handling, use, and disposition of thean option retained by the government, effective after the completion of the Pearl Harbor project and other projects under the December 11 contract. This option had no relation to the exchange elements of the contracts. There are terms used in the contracts which imply that in arriving at the basis of the exchange agreements certain pecuniary computations are made but under the decisions of the federal courts this method of ascertaining the quantum of the things sought to be exchanged does not destroy the exchange quality of the contracts.
But the plaintiff has earnestly contended that, assuming that the Act of June 4, 1920, grants to the Secretary of the Navy the power to exchange the royalty oil in the reserves for fuel oil and storage facilities, the contracts


the contractor at different times thereafter, and that the price thereof might at the date of delivery of a given quantity vary from the reference price of $1.50 specified in the contract. It was also stated that the delivery of royalty oil would be made at various times until the cost of the Pearl Harbor storage and the fuel oil to fill it was defrayed, and that at such times the published field price of such royalty crude oil might also vary from the specified reference price of $1.10 per barrel, and therefore, in order to protect the interests of both parties to the contract, and avoid making a purely gambling contract, it was provided that the quantities of crude oil delivered on the one hand and ofIt is his, and not the Secretary of the Navy's discretion that settles and determines such matters.
By the two contracts the Secretary of the Interior solely is also given vital and extensive powers requiring the exercise of discretion. Among these is the right to grant additional leases on such lands in the naval oil reserves as he may designate if he shall determine that the royalty oil from the reserves diminishes so that the Pearl Harbor contract will be unduly prolonged. And article XI of the contract of April 25, 1922, confers solely upon the Secretary of the Interior complete authority and power to determine when and upon what terms townships 30 and 31 south, range 24 east M. D. M., of reserve No. 1, may be leased


and vitality of the entire plan of the contracts and leases is gone.
These delegated powers are not merely incidental to any power retained by the Secretary of the Navy. They are not purely ministerial or administrative. They are in fact the principal controlling powers that the Act of June 4, 1920, vests exclusively in the Secretary of the Navy, so that he, and he only, can control and administer these reserves for the benefit of the Navy and of the United States. The delegated powers require the Secretary of the Interior to exercise judgment and discretion, and the attempted transfer of such powers from the Secretary of the Navy renders the contracts and leases void. Mechem on Public Officers, §§ 567, 568, 604; 1 McQuillin on Municipal Corporations,has been clearly established that such construction projects and property are of benefit *89 and value to the United States of America and to its Navy, and that the construction of such property has been done economically and without waste or extravagance, and that such constructed facilities are now available for use by the United States of America, and are now located on property of the government at Pearl Harbor, Hawaii, and that the money expended for the construction and completion of said storage facilities for crude oil products at Pearl Harbor, Hawaii, has been expended by defendants upon property of the United States of America and under the supervision and inspection of the duly appointed officers of the United States Navy.
Such property should be retained by the


the court did not commit error by its refusal to submit the Railroad's proposed instructions.
The Railroad also asserts, and more specifically, that the trial court erred when it submitted the following instruction to the jury:

"RAILROADS TO MAINTAIN SAFE CROSSINGS
"You are instructed that at the time of this accident and since 1890 the laws of the State of North Dakota provided:
"`All railroad corporations operating a line of railway in this state shall build or cause to be built and kept in repair, safe and sufficient crossings over such line at all points where it shall intersect any public highway in use.'"
The above instruction quotes § 49-11-05, N.D.C.C. The Railroad asserts that the instruction is misleading because the court did not also submit the language of § 49-11-06, N.D.C.C., which,introduces an extraneous subject, giving rise to conjecture and speculation.'
"To this we would only add that the incidence of income tax is no more relevant to the amount of the award ultimately available to the plaintiff than the amount of his contingent attorney fees, if any. If one is to be the subject of a jury instruction, so should the other. We hold that neither is an appropriate subject for jury instruction." 225 N.W.2d at 73-74.
During February of this year, the United States Supreme Court held in Norfolk and Western Railway Co. v. Liepelt, ___ U.S. ___, 100 S.Ct. 755, 62 L.Ed.2d 689 (1980), that it was reversible error to refuse to submit a jury instruction that "your award will not be subject to any income taxes, and


wire would have sagged." In affirming the trial court's order for a new trial this Court stated:
"There is no provision in the law that permits giving to the jurors any instruments or articles that have not been admitted as exhibits or used as instruments in explaining exhibits and as to the latter instruments they can only be allowed to the jury with the consent of counsel." King, supra 94 N.W.2d at 660.
The important distinction between the King case and the instant case is that the articles given to the jury for experimentation in King were neither properly admitted exhibits nor approved for jury experimentation by consent of the parties, whereas, in the instant case, the stopwatch was an exhibit admitted into evidence without objection by the Railroad. Wetestimony of prior accidents is admissible to show, among certain other things, that a dangerous situation or condition exists, providing that the facts of the prior accidents are substantially similar to those of the accident involved in the lawsuit. Stoler v. Penn Central Transp. Co., 583 F.2d 896 (6th Cir. 1978); Young v. Wlazik, 262 N.W.2d 300 (Minn.1977); Churchill v. Norfolk & Western Railroad Co., 46 Ill.App.3d 781, 5 Ill.Dec. 885, 362 N.E.2d 356 (Ill.App. Ct.1977), aff'd, 73 Ill.2d 127, 23 Ill.Dec. 58, 383 N.E.2d 929 (Ill.1978); St. Louis Southwestern Railway Co. v. Jackson, Admr., 242 Ark. 858, 416 S.W.2d 273 (1967); Freed v. Simon, 370 Mich. 473, 122 N.W.2d 813 (1963); Annot., 70 A.L.R.2d 167 (1960). This majority view has been extended to include admission of prior


not abuse its discretion by admitting Cysewski's expert testimony under Rule 702, NDREv. The matters about which Cysewski testified are of the type which the trial court could allow expert opinion to assist the jury in its determination of the issues. See Koch v. Southern Pacific Co., 266 Or. 335, 513 P.2d 770 (1973); Merchants Nat. Bank of Aurora v. Elgin, Joliet & Eastern Railway Co., 49 Ill.2d 118, 273 N.E.2d 809 (1971); Southern Pacific Co. v. Watkins, 83 Nev. 471, 435 P.2d 498 (1967); Bridger v. Union Railway Co., 355 F.2d 382 (6th Cir. 1966); Boston and Maine Railroad v. Talbert, 360 F.2d 286 (1st Cir. 1966).
The Talbert case involved an action to recover damages for injuries to and the death of plaintiff's husband as a resultit would not tolerate further such statements by the Souths' witnesses.
We conclude that the Railroad failed to make a proper and timely objection to the foregoing testimony upon which to predicate reversible error. In view of the statement of the Souths' counsel during the pretrial motion in limine that he considered such evidence admissible because of the stipulated photographs the Railroad should have been fully aware that the Souths' counsel intended to introduce such evidence. We conclude that the Railroad failed to preserve this error for appeal.
A second evidentiary item of alleged post-accident change involves a gyrolite, located on the engine of the train involved in the accident, which flashes a rotating beam of light. During the trial the Souths' expert witness, Whitman, was asked whether, during his


lights on *839 trains, and the Railroad objected only once to the following specific question:
"Q. What we're really talking about is the equipment that has been superseded in mechanical efficiency.
"[Railroad's counsel]: Object, it's irrelevant, incompetent and calls for a legal conclusion.
"[The Souths' counsel]: Going into the question of effect, Your Honor.
"THE COURT: Sustained."
Most of the testimony regarding gyrolites and strobe lights was admitted without objection by the Railroad. The two instances in which objection was made by the Railroad the trial court sustained the objections and a proper cautionary instruction was given to the jury. We conclude that with respect to the admission of this evidence the Railroad has presented no basis upon which to predicate reversible error.

(d) Table-Pounding Incident
While questioning South on redirect examination the Souths' counselyou wish to pound on the desk in my office, you may do so, but not before the jury. We'll see counsel in chambers."
The Railroad asserts that the pounding of the table by the Souths' counsel resulted in reversible error. We disagree. In view of the trial court's warning to the Souths' counsel, in the presence of the jury, that the court would not tolerate any such future "remonstrances", any prejudice resulting from the incident would have probably been against the Souths. It is inconceivable that such incident could have resulted in jury prejudice against the Railroad.

(e) Repeated Questions
The Railroad also asserts that reversible error was committed "throughout the trial" when the Souths' counsel would repeat a question that had previously drawn an objection which the trial court


had sustained, thereby allegedly forcing the Railroad to make a second and third objection. The only specific instance of such conduct to which the Railroad has referred involves the questions asked by the Souths' counsel just prior to the table-pounding incident. Upon reviewing the transcript we conclude that the Souths' counsel did not repeat the same question to which an objection had been sustained. Rather, the Souths' counsel substantially rephrased the question in an apparent attempt to elicit testimony acceptable to the trial court. Accordingly, we conclude that no error was committed in this regard.

(f) South's driving record
During closing argument the Souths' counsel made comments to the effect that the Railroad's failure to introduce any record of driving violations by South implied that South was a careful driverthe Railroad to a new trial.
The determination to grant or deny a new trial by reason of the misconduct of counsel rests within the sound discretion of the trial court, and, in the absence of a clear abuse of discretion, its determination will not be reversed on appeal. Kresel v. Giese, 231 N.W.2d 780 (N.D.1975); Hogan v. Knoop, 191 N.W.2d 263 (N.D.1971). We have reviewed the closing argument of the Souths' counsel, keeping in mind the alleged improper remarks raised by the Railroad on appeal, and we conclude that the trial court did not abuse its discretion in denying the Railroad a new trial by reason of counsel's conduct during closing argument.[6]

TESTIMONYCROSSBUCK MAINTENANCE
The Railroad asserts that the trial court committed prejudicial error by admitting evidence concerning the Railroad's


substantial evidence to establish with reasonable medical certainty that such future medical services are necessary. Holecek v. Janke, 171 N.W.2d 94 (N.D.1969).
Both South and his wife, Delores, testified that as a result of the injuries to South's left shoulder and right arm he required assistance to dress himself, to comb his hair, and to shower. They also testified that South was unable to drive a vehicle since his accident because he could not adequately maneuver the steering wheel. Delores further testified that subsequent to the accident South had fallen on more than one occasion and that it was impossible for him to get up without assistance. In addition to the foregoing testimony, Dr. John Beaumier, a specialist in orthopedics who treated South for the injuries he received duringlots of significance. It is believed that the Soma Kundam and Surya Kundam are referred in Silappathihaaram. Thiruvenkadu, one of the navagraha places is the Budhan sthalam dedicated to Planet God Mercury. Thiruvenkadu literally means, in Sanskrit as Shwetaranya or sacred white forest. This is also called as Adhi Chidambaram and the Chidambara Rahasyam is also here. As seen in Chidambaram, Lord Vishnu is near Nataraja, Lord Shiva. Special pujas are done to Lord Nataraja and the associated Spatikalingam, as in Chidambaram. The God is Shwetaranyeswarar and His wife is Goddess Brahma Vidyambal. It is believed that Suryan, Indran, Airvatam,Chandran and Budhan have worshipped Lord Shiva here. Thiruvenkadu is one among six holy places equl to Kasi. The other five are Thiriveni Sangamam ,Rameswaram, Gaya, Thilatharpanapuri and Srivanchiyam.


requested Lord Shiva to put an end to this evil. As they begged for rescue, Lord Shiva took his incarnation of 'Agora murthi' and killed 'Padmasuran under a tree.( which is now in Thiruvengadu temple, back to the entrance of idol of Agora murthi) All the people thanked Lord Shiva for saving them.themselves, the commission from these transactions replenishes the investment fund (IEF), which funds green projects.
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The highest point in the immediate area was Capitol Hill which, at that time, was owned by Jesse S. Viles, former owner of the Pavilion Hotel who approved of the idea of an observatory tower in the park.  In 1911, Viles deeded this parcel of land along with "a strip of land three rods wide" to serve as an approach into the park which became Hubbard Park Drive.

Dow's original plan for the tower was to provide fine views of the State House dome and the surrounding area. He planned for the tower to be visible from the downtown streets of Montpelier as to entice visitors to make the hike to the summit. Dow emphasized this point:

As a drawing attraction, it would pay to put up somethingof First and Magnolia. We have plenty of of Free Parking all over downtown and Lots of Laughs. Shows will run with major headliners every Friday and Saturday Night at 8 and 10pm. We have a Two Item Minimum (Any Combination of Food or Drink) We are a Full Full Restaurant Menu including Rib Eye Steak and Salmon, Lots of Salads, as well as delicious Wood Fired Pizzas, Mini Burgers Sliders, Gourmet Mac And Cheese Bar, Desserts and Appetizers. Come out and enjoy our fun and casual atmosphere all with a 1920s vibe. Lets just say we are "Still Celebrating the Repeal of Prohibition " Food Menu Available online. Pre-Purchase tickets suggested.

Born and raised outside of West Philadelphia, crowd after crowd, love the relatability in his situational humor.


are candidates to be implemented in the reconfigurable area, in order to be instantiated only when required. In this way, it is possible to save resources avoiding components that work sporadically being permanently implemented in the static part of the FPGA. This feature is an added value that can be exploited for preemptive systems.

Preemptive systems are those systems that have the ability to suspend the execution of a running task or process in order to run another task of higher priority, such as real-time systems and control systems. For real-time applications such as control applications, multimedia, medical monitoring, and robotic and automotive control, where the results must be produced within a well predefined interval of time to avoid unwanted consequences, we can consider two types of task operations:as well as task state management.

Task preemption is analyzed in several papers. In \[[@B12], [@B13]\], a way to extract and restore the execution state of a task in reconfigurable logic is described. State extraction can be obtained by rereading the bitstream of an FPGA to separate the state bits from the configuration ones. State information bits are those that contain all the information about current values of registers and internal memory of the FPGA. Keeping this information is mandatory to recover the last state when the task resumes. However, the extraction of that information, called FPGA read back, is a process that takes time (it requires parsing the entire bitstream of the FPGA). A method using the read back methodology is proposed in \[[@B14]\]. Another approach can be


arrive from outside the chip (off-chip communication).

If the execution of certain tasks that include partial reconfiguration is required, then it might be of interest to the remote activation of the reconfiguration process. In order to cope with this requirement, the OOCE middleware includes a device to facilitate off-chip communication. This device called Remote Network Interface (RNI) adapts different protocols such as Ethernet or RS232 to the system communication channel. [Figure 7](#fig7){ref-type="fig"} shows the block diagram of the RNI. The RNI, from the logical point of view, provides a bridge between two different middlewares, a commercial one and the internal system middleware OOCE. The RNI is the component that guarantees the interoperability between these two worlds (on-chip and off-chip). The mission of the *ICE-Bridge* component consists in processing andis first converted to 8-bit data (gray-scale image) and then is sent to the FPGA through the Ethernet port. The Control Component separates the payload of the message and sends the pixels and the HW-FAST configuration data such as the threshold and the amount of pixels to calculate the feature point. This new frame is the input of the HW-FAST component, which after work sends back a file with the coordinates of each characteristic point. The Packet-Mux component is the component that creates each file of coordinates when both HW-FAST components are working simultaneously and creates the data packets to be sent through the Ethernet channel. With these coordinates, the server recomposes the image, adding these points. With these points added to the map, in the mapping phase


of the PTAMM methods, the location is identified and the Augmented Reality components are added to the image to compose the localization and orientation service output.

The HW-FAST components and the Control and Packet-Mux components have been prototyped over the Xilinx Virtex 5 and Virtex 6 FPGA-based boards. For these tests, several reconfigurable areas have been defined using hierarchical layout, as represented in [Figure 5(b)](#fig5){ref-type="fig"}.

In areas prApp1 and prApp2 were implemented two HW-FAST components running the FAST algorithm for corner detection. These two implementations allow serving two clients simultaneously. The system is designed in such a way that allows the implementation of more HW-FAST cores depending on the demand implementing more HW-FAST components in reconfigurable areas when required.

The implementation of new HW-FAST components can require the eviction of somerunning in area prApp1 and a DES running in prApp2. Each time the number of logged users into the system requires an extra HW-FAST, the reconfiguration mechanism is triggered and the DES component is stopped and prApp2 is reconfigured instantiating a new HW-FAST component inside prApp2.

6.1. Preemption Overhead Evaluation {#sec6.1}
-----------------------------------

As previously stated the preemption overhead is formed by (1) the stop of the low-priority task and its state saving process, (2) the reconfiguration of the area, and (3) the load of the state of the high-priority task.

### 6.1.1. Stop Task and State Transference {#sec6.1.1}

In our example, to stop the DES component it takes 2 clock cycles.

To test this proposal for state transference several dynamic objects of different sizes were evaluated. The FIFO width was 32 bits in the implementation,


reconfiguration speed, the time *T* ~pr~ consumed in reconfiguring these bitstreams is: $$\begin{matrix}
{T_{\text{pr}} = 1.90351\,\text{ms}\quad\text{for}\,\,\text{HW-FAST}{\,\,}\text{component},} \\
\end{matrix}$$ $$\begin{matrix}
{T_{\text{pr}} = 2.90664\,\text{ms}\quad\text{for}{\,\,}\text{DES}{\,\,}\text{component}.} \\
\end{matrix}$$

### 6.1.3. Loading State of High-Priority Task {#sec6.1.3}

Once the HW-FAST was reconfigured in area prApp3, the next step is to transfer its state from memory. The state is formed by the pointer to memory to extract the pixels of the frame and the 49 bytes corresponding to the ring of pixels being analyzed. If the preemption mechanism is triggered by a request of a new HW-FAST, initially this component does not need to load state. So there is no time consumption in loading initial state.

Therefore, the total Preemption overhead is then (according to ([3](#EEq3){ref-type="disp-formula"}), ([7](#EEq6){ref-type="disp-formula"}), and ([8](#EEq7){ref-type="disp-formula"})) $$\begin{matrix}
{T_{\text{PO}} = 0.00142 + 1.90351 = 1.90492{\,\,}\text{milliseconds}.} \\
\end{matrix}$$

Finally, the EWCET (see [Figuremurders Janna by stabbing her in the back as she's washing her hair. Meanwhile, Josh is looking at maps, making phone calls, and chain smoking presumably trying to locate Leslie.

When Leslie returns home from work, she finds Janna's body and believes that it was Josh who killed her. Tor consoles Leslie and soon plays a harmonica and admits that he was the one who killed Janna because he believed that she was a corrupting influence on Leslie. Tor then begins to tell her how much he loves her. Leslie runs off into the wilderness after slashing him across the face with a car key while he professes his love for her. While chasing Leslie, Tor hears Josh's car pull up, and murders him by slashing his throat, leaving


Eric Myers reviews The Lion Roars

The Lion Roars: The Musical Life of Willie ‘The Lion’ McIntyre
By Phil Sandford
Self-published, 214pp, $22
________________________________________________________Eric Myers, The Australian, 3-4 November 2018
Phil Sandford’s The Lion Roars is a reminder of how vibrant the
Melbourne jazz scene was in the late 30s and early 40s, as an
unprecedented generation of talented young musicians emerged.
Strong personalities, they created a sub-culture with such capital that,
in the immediate post-World War II years, jazz was first cab off the
rank in taking Australian music, indeed Australiana, to the rest of the
world. Here we are primarily talking about the overseas exploits of
Graeme Bell and his Australian Jazz Band. To some extent that’s
another story.
Pianist and singer Willie “The Lion” McIntyre, a mere footnote in
many previous accounts, has now been fleshed out in commendable
detail. Hein -3, 0, -0.5, 0.031?
0
What is the closest to 0 in 3, -1/10, 24, 0.2?
-1/10
Which is the nearest to -1?  (a) -0.4  (b) 4/5  (c) -0.1  (d) -56/5
a
Which is the nearest to -2/13?  (a) 55/6  (b) 0  (c) 0.3
b
Which is the closest to -1?  (a) -3  (b) -4  (c) -1/3  (d) -105
c
What is the nearest to -2 in -14, -1, 1/5, 6?
-1
What is the closest to -0.1 in 672, 0.1, -4?
0.1
Which is the nearest to 0?  (a) -3  (b) -3/34  (c) -1
b
What is the closest to 2/59 in 5/4, -2/15, -2?
-2/15
What is the closest to 2/7 in 2, 0.09, -3, -2/19?
0.09
What is the nearest to 4 in 0.5, -4, 1/5, -0.2?
0.5
Which is the nearest


to 5/3?  (a) -6  (b) 2  (c) -4  (d) 3
b
What is the closest to -0.1 in 12, 0.1, 2, -4/3?
0.1
What is the closest to 0.1 in 4, 2, 31, -1?
-1
What is the closest to 3 in -46, -5, 1?
1
What is the closest to -1/4 in 4, -4, -0.3, 11.9?
-0.3
Which is the closest to 0.01?  (a) -0.3  (b) 9  (c) -16  (d) -6/7
a
Which is the nearest to -0.1?  (a) 0.5  (b) 16.5  (c) -71
a
Which is the closest to -1?  (a) -0.2  (b) -82  (c) -2
a
Which is the closest to 8?  (a) 0.07  (b) -2/15  (c) 2/21  (d) 3
d
Which is the closest to -3?  (a) -0.4  (b) 0  (c)TRPV2 activation induces apoptotic cell death in human T24 bladder cancer cells: a potential therapeutic target for bladder cancer.
To investigate the functional expression of the transient receptor potential vanilloid 2 (TRPV2) channel protein in human urothelial carcinoma (UC) cells and to determine whether calcium influx into UC cells through TRPV2 is involved in apoptotic cell death. The expression of TRPV2 mRNA in bladder cancer cell lines (T24, a poorly differentiated UC cell line and RT4, a well-differentiated UC cell line) was analyzed using reverse transcriptase-polymerase chain reaction. The calcium permeability of TRPV2 channels in T24 cells was investigated using a calcium imaging assay that used cannabidiol (CBD), a relatively selective TRPV2 agonist, and ruthenium red (RuR), a nonselective TRPV channel antagonist. The death of T24 or RT4 cells


in the presence of CBD was evaluated using a cellular viability assay. Apoptosis of T24 cells caused by CBD was confirmed using an annexin-V assay and small interfering RNA (siRNA) silencing of TRPV2. TRPV2 mRNA was abundantly expressed in T24 cells. The expression level in UC cells was correlated with high-grade disease. The administration of CBD increased intracellular calcium concentrations in T24 cells. In addition, the viability of T24 cells progressively decreased with increasing concentrations of CBD, whereas RT4 cells were mostly unaffected. Cell death occurred via apoptosis caused by continuous influx of calcium through TRPV2. TRPV2 channels in UC cells are calcium-permeable and the regulation of calcium influx through these channels leads directly to the death of UC cells. TRPV2 channels in UC cells may be aCOMES OUT OF YOUR DICK BITCH!" Mr. Ratburn shouted and almost fell out of his chair, half of the class was laughing or giggling.

"Uh... Okay, can you use it in a sentence?" Francine asked again.

"PISSSSSSSSSSSSSSSSSSSSSS!" Mr. Ratburn shouted from behind his desk.

"Uh... P-I-S-S... Piss..." Francine spelled out.

"Good... you can stay up there in line WITH THE OTHER FUCKING RETARDS!!!" Ratburn shouted, "ARTHUR STOP TOUCHING YOUR DICK!"

"But I'm not touching my..." Arthur tried to explain as his hands were no where near his crotch.

"YOU'RE TOUCHING YOUR DICK STOP IT YOU LITTLE PUSSY!!!" Ratburn shouted while he pointed.

"Uh Mr. Ratburn, can I go to the bathroom? I still didn't go a couple hours ago..." Binky asked.

"GO SHIT IN YOUR DESK!!!" Ratburn yelled.

"Boy I'm already counting the days until summer arrives..."


they engage in sharing of injection paraphernalia \[[@B29],[@B30]\].

Among IDUs, HCV prevalence was significantly higher among IDUs in Lahore who had been injecting drugs for two or more years and is consistent with findings from previous studies \[[@B31]\]. The fact that HCV prevalence was higher in Lahore than in Quetta is likely explained by the fact that injectors from Lahore had been injecting for significantly longer. Most drug users in Lahore injected drugs rather than chased the dragon, while the opposite was true in Quetta. Quetta is situated very close to Afghanistan, the world\'s largest producer of heroin \[[@B32]\]; due to its proximity to the border and relatively easy access to heroin supplies, heroin use in Quetta mainly consisted of chasing and smoking. Towards the end of its rulein 2001, the Taliban government in Afghanistan prohibited the opium trade and further interruptions in the drug trade as a result of the U.S-Afghan war led to lower availability of heroin in the surrounding area (e.g., Quetta) and is thought to have facilitated the recent trend in switching from heroin chasing to injection of pharmaceutical opiates \[[@B33]\].

Other behaviors unrelated to drug use were also independently associated with HCV seropositivity. IDUs from Quetta who had ever received a barber shave had a marginally higher odds of HCV seropositivity, consistent with other studies in non-drug using populations in both developed and developing nations \[[@B34]-[@B38]\]. Barbering in makeshift stalls or on the street is common in Pakistan and is often conducted under unhygienic conditions. The lifetime prevalence of barber shaving was


Danish, Mateen Izhar, Dr. Rozi Kakar, Dr. Faisal Khan, Amir Rehman, Dr. Shafiq, Syed Nauman Shah, Dr. Ziauddin, and Mohammad Zulfiqar. Funding for this study was provided by the National Institute for Drug Abuse (NIDA; grants R01-DA09225 and F31-DA15291).
cascade of events, just as, for example, hemostasis does. Controversy about diagnosis exists all over. For example, how does one make a diagnosis? Patient history has been considered unreliable. A standardized cold test, though highly reproducible in the authors' hands, is far from common property. Raynaud's syndrome is a condition for which thirty-eight therapies have been advocated in the last three years, but the curative answer is still to come.


government—the State Department in particular—consistently blocks counterterrorism investigations that come too close to certain top-level people. “We go for the Attas and Hamdis—but never touch the guys on the top.… [It] would upset ‘certain foreign relations.’ But it would also expose certain of our elected officials, who have significant connections with high-level drugs- and weapons- smuggling—and thus with the criminal underground, even with the terrorists themselves.… [A]ll of these high-level criminal operations involve working with foreign people, foreign countries, the outside world—and to a certain extent these relations do depend on the continuation of criminal activities.” Edmonds says that the government’s investigation into the financing of al-Qaeda is a case in point. “You know, they are coming down on these charities as the finance of al-Qaeda.… [But] aDepartment is highly critical, calling it “a collection of unfounded conspiracy theories that bear no relationship to the tragic realities of September 11.” As part of a series of “conspiracy theory” debunking web pages entitled “Identifying Misinformation,” the State Department attempts to rebut each of the main points of the book. [US Department of State, 9/16/2005]

A US Army intelligence officer comes forward, saying he was involved with a secret military intelligence unit, which had identified Mohamed Atta and three other future 9/11 hijackers by mid-2000. He says the unit, called Able Danger, had tried to meet with agents at the FBI’s Washington field office that summer to share its information, but was prevented from doing so by military lawyers (see September 2000). Lt. Col. Anthony Shaffer, who served


arms depots just across the border from Pakistan. [Knight Ridder, 8/18/2005]

Mounir El Motassadeq is convicted in Germany of belonging to a terrorist organization and sentenced to seven years in prison. However, he is acquitted of involvement in the 9/11 plot. He had previously been convicted of such involvement (see February 18, 2003), only to have the ruling overturned later (see March 3, 2004). The verdict was overturned when a judge ruled he was unfairly denied testimony for al-Qaeda suspects in US custody such as Ramzi bin al-Shibh. For the retrial, the US provided summaries from the interrogation of bin al-Shibh and other suspects, but did not make full reports available to the court or allow the prisoners to appear in person for cross-examination. The judge presiding over the500 investigators. Police staked out Patterson and Washington, and arrested them after they robbed a Chevron station on July 5. A search of Washington’s apartment turned up bulletproof vests, knives, jihad literature, and lists of potential targets. There was further evidence indicating that Patterson was in the process of acquiring an AR-15 assault rifle. [New York Sun, 9/6/2005] Yang says that the “evidence in this case indicates that the conspirators were on the verge of launching their attack,” adding that the arrest has exposed “a chilling plot based on one man’s interpretation of Islam.” [Reuters, 8/31/2005] Many of the court documents are sealed, but it is known that the trial date was “continued” from October 24, 2006 to August 27, 2007. All four men plead not guilty. The


Hormuz Plot - In 2002 the US and partners disrupted a plot to attack ships transiting the Straits of Hormuz. 2002 Arabian Gulf Shipping Plot - In late 2002 and 2003 the US and a partner nation disrupted a plot by al-Qaeda operatives to attack ships in the Arabian Gulf. 2003 Karachi Plot - In the spring of 2003 the US and a partner disrupted a plot to attack Westerners at several targets in Karachi, Pakistan. East Coast Airliner Plot - In mid-2003 the US and a partner disrupted a plot to attack targets on the East Coast of the United States using hijacked commercial airplanes. 2003 Tourist Site Plot - In 2003 the US and a partner nation disrupted a plot to attack a tourist site outsideborder has lost all power supplies.” However, the state of bin Laden’s kidneys will still be shrouded in mystery two years later (see Late 2007). According to the report, Pakistani President Pervez Musharraf has agreed to keep other rescue teams working to locate survivors away from the border area where the search for bin Laden is concentrated. [Daily Times (Lahore), 10/20/2005] There are no reports that the search is a success. A man thought to be bin Laden will continue to release audio messages (see, for example, January 19, 2006).

James Quintiere. [Source: University of Maryland]During a House Science Committee hearing on the key findings and recommendations of the National Institute of Standard and Technology (NIST) investigation into World Trade Center collapse, a fire expert raises several concerns. James


to have taught the use of poisons and chemicals at Afghanistan training camps and he is suspected of a role in the 2004 Madrid train bombings (see 7:37-7:42 a.m., March 11, 2004) and the 7/7 London bombings (see July 7, 2005). But he is best known for his strategic writings. The Washington Post calls him “one of the jihad movement’s prime theorists.” He long advocated a decentralized militant movement, and was often critical of bin Laden’s and al-Qaeda’s mistakes. He says, “Al-Qaeda is not an organization, it is not a group, nor do we want it to be. It is a call, a reference, a methodology.” He is soon flown out of Pakistan and into US custody. In 2006, US intelligence sources will claim that he is nowwill comment, “It is unclear what weight an opinion from a lawyer within the clandestine service would have if it were not formally approved by Mr. Rizzo. But [an anonymous former official] said Mr. Rodriguez and others in the clandestine branch believed the legal judgment gave them the blessing to destroy the tapes.” The former official will also say they “didn’t need to ask Rizzo’s permission.” [New York Times, 12/11/2007] A lawyer acting for Rodriguez will later say, “He had a green light to destroy them.” [New York Times, 12/19/2007] However, other former CIA officers will express surprise that a lawyer junior to Rizzo would approve such a controversial decision without asking for his input. Former CIA lawyer John Radsan will say, “I’d be surprised that even the


imprisoned there. He is reportedly extremely ill with tuberculosis and diabetes. It is said the Libyan government has kept silent about holding al-Libi as a favor to the Bush administration, to help avoid more public scrutiny about him. [Newsweek, 5/29/2007]

Wolfgang Bohringer. [Source: TVNZ]A German citizen suspected by the FBI of having had links with alleged 9/11 ringleader Mohamed Atta arrives in the remote South Pacific archipelago of Kiribati, one of the world’s smallest nations. Wolfgang Bohringer wants to set up a tourist resort and flight school on the isolated outpost of Fanning Island, which is only 13 square miles in size, has no phones or a functioning airstrip, and is home to just 600 people. Its only advantage is that it is among the closest of the islandsblame for bringing down the WTC buildings after all.” He says the official explanation for the collapses—that fires and structural damage caused them—cannot be backed up by either testing or history. The Pittsburgh Tribune-Review will comment, “Jones isn’t the first to make this shocking/unbelievable claim… But it’s hard to imagine anyone making it clearer.” Jones, who conducts research in fusion and solar energy, wants a new, independent investigation into what caused the collapses. [Deseret Morning News, 11/10/2005; KUTV 2 (Salt Lake City), 11/10/2005; MSNBC, 11/16/2005; Pittsburgh Tribune-Review, 11/20/2005]

Saijida Mubarak Atrous al-Rishawi confesses on Jordanian television to attempting to be one of the suicide bombers. Her bomb belt is also shown. [Source: BBC / Jordanian Televison]Three hotels in Amman, Jordan are simultaneously bombed. Sixty people, including three bombers, are


Bomb' Allegations 'Not Credible,' Says Former FBI Agent - Retired FBI agent Jack Cloonan, an expert on al-Qaeda, later says: “The dirty bomb plot was simply not credible. The government would never have given up that case if there was any hint of credibility to it. Padilla didn’t stand trial for it, because there was no evidence to support it.” [Vanity Fair, 12/16/2008]Issue with CIA Videotapes - In 2002, captured al-Qaeda leader Abu Zubaida identified Padilla as an al-Qaeda operative (see Mid-April 2002) and the government cited Zubaida as a source of information about Padilla after Padilla’s arrest. Yet, sometime this same month, the CIA destroys the videotapes of Zubaida’s interrogations from the time period where he allegedly identified Padilla (see November 2005). The Nation’s Aziz Huq willdestroy the Brooklyn Bridge. But he says that al-Qaeda’s capabilities remain unclear and the group is still dangerous. [Associated Press, 12/2/2005]

A report by the Justice Department’s Office of the Inspector General is leaked to the New York Times. The report largely backs the allegations made by whistleblower ex-FBI agent Mike German (see September 2002 and August 2, 2004). It finds that FBI officials mishandled a terrorism investigation German was involved in, falsified documents in an effort to cover up agency mistakes, and retaliated against German. In one instance, someone altered dates on three FBI forms using correction fluid to conceal a violation of federal wiretap law. After German tried to complain directly to FBI Director Robert Mueller, other FBI agents distanced themselves from him. For instance, the head


avoid scrutiny of a particular event in which the state or its servants have a definite interest.… A ‘narrative’ is no substitute, especially for the families of those killed in the bombings, for a robust inquisitorial process aimed at determining the truth. No lessons will be learnt from it for the future protection of our people against such terrorist attacks.” [Daily Telegraph, 12/15/2005]

After an NSA program to intercept telephone calls where one party is in the US and the other party is abroad is revealed (see December 15, 2005), President George Bush defends the program in a radio address. He justifies the program by implying that, if it had been in place before 9/11, it may have prevented the attacks: “As the 9/11 Commission pointed out, it wasclear that terrorists inside the United States were communicating with terrorists abroad before the September the 11th attacks, and the commission criticized our nation’s inability to uncover links between terrorists here at home and terrorists abroad. Two of the terrorist hijackers who flew a jet into the Pentagon, Nawaf Alhazmi and Khalid Almihdhar, communicated while they were in the United States to other members of al-Qaeda who were overseas. But we didn’t know they were here until it was too late.” There are conflicting accounts of the circumstances of the hijackers’ calls and the NSA actually intercepted them, so it is unclear why they were not exploited to prevent the attacks (see Early 2000-Summer 2001, (Spring 2000), Summer 2002-Summer 2004, and March 15, 2004 and After). [WhiteHouse(.gov), 12/17/2005;


a Predator up there for hours at a stretch, just watching, watching.” The CIA closely studies the layout of the compound in preparation for a drone strike. “They took a shot at the compound a week after I left. We got some bodyguards, but he was not there.” Under US policy at this time, the CIA needs permission from the Pakistani government before any drone strike, and getting the approval can take a day or more. Apparently, such delays contribute to the failure to successfully kill Habib. Habib will finally be killed in a Predator strike in 2008. [Los Angeles Times, 3/22/2009] There are no contemporary media accounts of any Predator strike at Miram Shah in 2006, so the date of the strike remains unknown.

After 9/11 there waspoints out that “these are only theories” but still notes that “[h]alf the guys in the Bureau think CIA was trying to turn them to get inside al-Qaeda.” [Wright, 2006, pp. 313; Media Channel, 9/5/2006]Participant Does Not Know - Doug Miller, an FBI agent loaned to the CIA who was part of a plot to withhold the information from the FBI (see 9:30 a.m. - 4:00 p.m. January 5, 2000), will indicate he does not know why he was ordered to withhold the information, but that his superiors may have had a good reason for keeping it from the FBI. Another intelligence source will claim that the CIA withheld the information to keep the FBI away from a sensitive operation to penetrate al-Qaeda. [Congressional Quarterly, 10/1/2008]CIA Wanted to


even need to be an engineering . There are many different ways . You will see this later in life that people do well from all walks of life .

I think education needs to evolve and change just like with everything else . Getting into an institution doesn't guarantee success . It matter a lot but it doesn't guarantee success . It would like to see people value creativity , value experience of doing things , taking risks. It is important to be well rounded. I had encourage people to take some risks, follow their passions a little bit more and enjoy what you're doing and what matters most is loving what you are doing trying to do well at it . So I think if you follow R[2] = A[1] ;
  R[3] = A[3] ;
}

double
det2 (double A [4])
{
  return A[0]*A[3] - A[1]*A[2];
}

void
check_svd (double *M , double * U, double * S, double *V)
{
  double T1 [4] ;
  double T2 [4] ;

  print_matrix("M",M) ;
  print_matrix("U",U) ;
  print_matrix("S",S) ;
  print_matrix("V",V) ;

  transp2(T1, V) ;
  prod2(T2, S, T1) ;
  prod2(T1, U, T2) ;
  print_matrix("USV'",T1) ;

  transp2(T1, U) ;
  prod2(T2, T1, U) ;
  print_matrix("U'U",T2) ;

  transp2(T1, V) ;
  prod2(T2, T1, V) ;
  print_matrix("V'V",T2) ;

  printf("det(M) = %f\n", det2(M)) ;
  printf("det(U) = %f\n", det2(U)) ;
  printf("det(V) = %f\n", det2(V)) ;
  printf("det(S) = %f\n", det2(S)) ;
  printf("\n") ;
}

int
main (int argc VL_UNUSED, char ** argv VL_UNUSED)
{
  double


M[2], M[3]) ;
  V[2] = -V[1] ;
  V[3] = V[0] ;
  U[2] = -U[1] ;
  U[3] = U[0] ;
  check_svd(M, U, S, V) ;
  return 0 ;
}
Israeli militants who support the settlement movement infiltrated an army regional division headquarters in the West Bank, set tires on fire, vandalized vehicles and scattered nails on the road. Senior officers also were attacked with rock

According to schedule, Benjamin Netanyahu's government has until November 2013 before elections but a recent flurry of activity is injecting new life into the Israeli political system and shaking it up a bit.

Iran, United States, Israel, nuclear, Strait of Hormuz: The deepening standoff between Tehran and the West over Iran's nuclear program has Iranians chatting nervously in butcher shops, grocery aisles and money exchanges.

Three explosions rattled downtown Bangkok on Tuesday, a day after bombers targeted Israeli embassy staff in India and Georgia, and police announced that at least one of the suspects in


to each other and each department to each other, and to gain it from the customers.

This is the operational result. This isn’t achieved through campaigns or any one department “getting” social media and social business, no matter how great the result. It’s achieved through hard work of the consulting team, the client’s team, and the various collaborating parties. Again, the frameworks and the interfaces and the measures for these complex activities need to all become institutionalized – this is the business of project implementation and change management and technology selection and integration. Social media per se isn’t driving this success.

2011 is the year in which more groups will merge and emerge, and Social Businesses will very clearly emerge as a new competitive force. We know, from Altimeter, thatfirms create optimal customer experiences by integrating social data, teams & processes with enterprise systems.
The much vaunted 360-view of the customer can be a bottomless pit without a clear data strategy. I help you deliver a greatly improved customer experience starting with a "45-degree" view of the customer, fully utilising social data analytics. I clarify your objectives and what data you need to service them, and guide you to operationalise "social at scale" to consistently deliver valuable customer experience at every social touch point.

Most brands haven't mastered customer experience (CX). Get the findings from new research with 1,000 US consumers and 300 brands to understand areas of CX alignment and disconnects. Learn where and why brands are still struggling, and how to turn the tide.

Combining his own professional


Quebec

In 2008 the 12th Duke and Duchess re-established ‘Quebec’, a long-overgrown area below the Canal Pond. The 9th Duke may have named this area on his return from bring Governor-General of Canada. When this area was cleared, a cascade dating from the early 1700s was revealed.

Déjeuner sur l’Herbe, by the sculptor and artist, Allen Jones is situated at the south end of Quebec.

RHS Chatsworth Flower Show

We are delighted to be welcoming the RHS to Chatsworth for the first of many memorable flower shows. Bold and innovative this new show is set to be simply amazing.Search Results

Interview: Matt Korvette (of Pissed Jeans)

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People love to reminisce about the early days of Sub Pop. There’s a certain romanticism that comes with recalling the DIY movements of zines and hand-drawn flyers, led by west coast bands leading the fight not only to become heard, but to be respected from an ambivalent public. Bands like Mudhoney and Nirvana were masterful in spurring reactions from discontent, of course.

But even amidst the struggle for relevance amidst a media landscape that shifts daily, contemporary sludge-punks Pissed Jeans embody that very same homegrown mentality while honing in on a hardcore vibe that’s entirely their own. In light of their fourth album, the CoS Top Star-earning Honeys, I chatted with perpetually shirtless frontman Matt Korvette about the new record, male gazes,


But he clearly already had, it was pretty gross. Bad band name choice, kind of gets you in the end. Like imagine if you band was called the Diarreah Eaters, and people took that to heart. Much better to be something like, The Lottery Ticket Accepters. Or the Comfortable Couch Sitters. Maybe then people would come up to us and say, “Man I’ve got this really comfy couch you guys gotta try out.”

Or the Free Ice Cream Taste Testers.

Definitely.

I guess things would have really gotten weird then if you guys had gone with your original band name, Unrequited Hard-On.

That was probably just as crass. I barely can recall how that band name stuff went down. Maybe I should have paid better attention at the time.What Does it Mean to Choose a Bad Executor?

In the process of establishing your estate planning goals, you have to make key decisions about other people. For example, selecting your power of attorney means thinking about who you trust to make legal or financial decisions on your behalf if something happens to you.

A will is your opportunity to establish a guardian for your child which means that not only must you be clear about this person’s ability to serve in this role, but you must have a conversation about their willingness to step in and parent your own child. Finally, another individual who might be named with a powerful role in your estate is known as the executor.

Your executor is the person who administers your estate and it