([@b51]), p38γ ([@b52], [@b53]) and p38δ ([@b51]). SB203580 is a selective inhibitor for both, p38α and β, but has no effect on the activity of the γ and δ isoforms. The inhibition of the anisomycin-induced EGFR internalization observed in the presence of SB203580 strongly suggests the involvement of p38α and/or p38β in this process. The additive effect of p38α and p38β silencing on EGFR internalization after anisomycin treatment corroborate that both isoforms likely play an important role in the regulation of EGFR trafficking. It is important to note that, while inhibition of p38 activation clearly prevented EGFR entry into the cells, no effect on transferrin internalization was observed, indicating that SB203580 does not cause a general block of clathrin-mediated endocytosis.

Recently, it has been shown that exposure of cells case" before the  tax court,  relating to  a

          similar  tax shelter.  The  Form 906 closing agreement authorized

          IRS to assess a tax deficiency within one year after the decision

          in the controlling case became final, notwithstanding the expira-

          tion  of  any period  of  limitation prescribed  by  the Internal

          Revenue Code.   The closing  agreement made no  reference to  the


__

          Hempel v. United States, 14 F.3d 572, 575-76 (11th Cir. 1994).
          ______    _____________

                    The first  argument raised  by IRS on  appeal, but  by-

          passed in the tax court, maintains that the Forms 872-A submitted

         <!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" "http://www.w3.org/TR/html4/loose.dtd">

<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">

<title>BenchmarkTest01533</title>

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	<input type="text" id="secure" name="secure"></input>

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	<input type="text" id="BenchmarkTest01533" name="BenchmarkTest01533" value="FOO=echo Injection"></input>

	<input type="submit" value="Post it" />

</form>


the use of energy efficiency (EE) as an important clean energy approach in developing countries. Through our regional offices, we have been effective in bringing about progress in EE policy and implementation that has both reduced energy consumption by thousands of MWs and fostered economic development in the countries we serve. The IIEC works with stakeholders across all sectors to connect international best practice with the unique needs of the communities in which we operate, combining sound EE and renewable energy policy with hands-on implementation in order to reduce greenhouse gas emissions and encourage sustainable development.Social media firms form the Global Internet Forum to counter terrorism

Social media companies led by Facebook said Monday they were ramping up an industry body that aims to weed out extremist content, seeking to put procedures in place globally on how to handle crises.

Facebook announced additional efforts at the United Nations during a meeting with New Zealand's Prime Minister Jacinda Ardern, who has taken up the cause of fighting online extremism after a March massacre by a white supremacist at two mosques in Christchurch.

"We are trying to create a civil defense-style mechanism. The same way we respond to natural emergencies like fires and floods, we need to be prepared and ready to respond to a crisis like the one we experienced," she told reporters.

Facebook, Twitter, Microsoft and YouTube


incitements to violence online and how to reduce the effects on social media when attacks occur.

The forum will still amount to a voluntary effort by tech companies to police themselves.

Government regulation is anathema for major US tech companies and their libertarian-minded philosophy, although a growing number of countries outside the West have sought to force social media platforms to censor unwanted content.

Ardern indicated she had no intention of seeking new regulations, which she said made little sense when pursuing ideas such as steering social media users away from extremist material to alternative, curated content.

"If we want the greatest gains, we actually need to collaborate," she said.

"There is nothing we had seen, even at this point several months on, that has ever suggested to me that any of thesethe way color is printed. Because image colors can shift when you switch from one mode to another, it makes sense to adjust the color in a picture according to the way it will be displayed. For a picture that’s going on a web page, you should work in RGB mode. If your picture will be printed on a four-color process commercial press, work in RGB to start with, but make your final adjustments (if any are needed) after you convert the image to CMYK mode. If you’ll be printing on a home/office inkjet printer, stick with RGB, even though your printer uses CMYK inks. The software drivers for desktop inkjet printers are designed to convert from RGB to CMYK internally. Other kinds of color printers, such as


more readable.
if name in [pos['name'] for pos in a]:
    if number == [dd for dd in a if dd['name'] == name][0]['number']:
        print('okay')
    else:
        print('user okay but incorrect pass')
else:
    print('No username')

Or alternatively, if you are ok with a for loop:
for dd in a:
    if name == dd['name']:
        if number == dd['number']:
            print('okay')
        else:
            print('user okay but incorrect pass')
        break
else:
 As many as 27 people, including the gunman, were killed Friday morning when a man opened fire at Sandy Hook Elementary School, according to reports. Ossining police Capt. Scott Craven went to schools in the Ossining Union Free School District to provide support and comfort to families, Ossining school officials said. Briarcliff Manor school district officials confirmed that members of the Briarcliff Police Department were on hand at Todd Elementary School.

"Our hearts and sympathies are extended to all,” Phyllis Glassman, superintendent of the Ossining school district, said in a statement Friday. “Please know that in the Ossining School District and the greater Ossining Community, we have been proactive in order to protect our students, staff, and community at large.”

Glassman said she had been in contact with representatives of


the Board of Cooperative Educational Services, and district officials would address the incident further beginning next week.

“As always, and next week in particular, our principals will once again review their School Emergency Plans with their School Emergency Response Teams to reinforce our vigilance in protecting our students and staff as well as ensuring high levels of safety and security,” she said in the statement. “As partners in protection of everyone in our schools and community, we thank you, too, for your efforts relative to safety and security.”

Neal Miller, superintendent of the Briarcliff Manor Union Free School District, said he was “extremely saddened” when hearing the news coming out of Connecticut.

“It’s absolutely unthinkable and horrific, and we’re all affected when something like this happens,” Miller said. “It makes everyone2002 F250 CCLB Build

Thats like my dad with his 09 ram. It takes about 5 qts and there was 1/2 a qt in it! He got it done at the place where we usually go to get our cars worked on and if you have seen my steering issue thread you can tell I'm not thrilled anymore lol. He told me he got his oil changed 6 weeks ago and since then every morning he would hear slight ticking when the engine was cold and he would get some blue smoke. That initially lead me to believe it was an internal engine issue but after putting 4 3/4 qts in it to get it back tot he safe zone I don't think it would eat that much oil


'binding', 'adhesion' and 'cell cycle'.

The results of the enrichment of DEG function and signaling pathways ([Table III](#tIII-mmr-19-01-0362){ref-type="table"}) demonstrated that the downregulated genes were mainly associated with the complex biological behavior of CLL. Using P\<0.05 as a cut-off criterion, 17 KEGG pathways were over-represented in downregulated DEGs, including 'hematopoietic cell lineage', 'transcriptional dysregulation in cancer' and 'pathways in cancer', while the four KEGG pathways involved in the upregulated DEGs were enriched in multiple signaling pathways, the 'cyclic adenosine monophosphate (cAMP) signaling pathway' and the 'mitogen-activated protein kinase (MAPK) signaling pathway'. These most significantly enriched GO terms and KEGG pathways demonstrated the interactions of DEGs at the functional level.

### PPI network construction and module selection

Using the STRING online database and Cytoscape software, a total of 354 DEGs were filtered intoof apoptosis, *MYC* was identified as one of the mutant genes that demonstrated the highest degree of connectivity in the present study. It is known that *MYC* serves an oncogenic role in many cancer types, including prostate and bladder cancers ([@b33-mmr-19-01-0362],[@b34-mmr-19-01-0362]), and serves an important role in leukemia and lymphomas ([@b35-mmr-19-01-0362],[@b36-mmr-19-01-0362]). In the present study, *MYC* was differentially expressed and was enriched in the transcriptional dysregulation of cancer and chronic myelogenous leukemia. *BCL2* is the first discovered inhibitor of apoptosis and serves a key role in promoting cell survival. Many studies have demonstrated that *BCL2* is one of the most important oncogenes involved in cancer ([@b37-mmr-19-01-0362]--[@b39-mmr-19-01-0362]), inducing the development of lymphoma, together with *c-MYC* overexpression, in particular ([@b40-mmr-19-01-0362]). In the present study, *MYC* and *BCL2* were identified as


present study provides new theoretical guidance for further exploring the mechanism of CLL and provides a novel perspective for understanding the underlying biological processes of CLL and miRNA-targeted therapy.

Taken together, the present data demonstrated that the molecular mechanisms of CLL can be understood and that biomarker prediction can be achieved through data mining and integration. Overall, 488 candidate genes and 32 different miRNAs from multiple datasets were screened by bioinformatics analysis. From the PPI network of DEGs, 12 major altered hub genes and multiple pathways associated with the development of CLL were identified, such as the Jak-STAT signaling pathway, the PI3K-Akt signaling pathway and the MAPK signaling pathway. In addition, the comprehensive bioinformatics analysis of DEGs and the construction of miRNA-mRNA regulatory network provides a bioinformatics approach towith Sophia Delza. The form she was teaching did not fulfill my intuition of how I thought t’ai chi would feel nor did the other classes I researched. It was not until I saw Professor’s classes and then of course finally started studying his short yang form that it really felt how I imagined t’ai chi could be. Each time I went for treatment from Professor I happily sat through his classes and observed him teaching until he was ready to see me. Some of them were t’ai chi ch’uan classes; most of them were t’ai chi sword classes. Sometimes when I arrived at the studio on Canal Street he was just finishing a calligraphy or flower arranging class. Just by watching I could feel that this was


not work out as I hoped. But t’ai chi helped me nonetheless. While I was in labor and had back pain t’ai chi supported me throughout the process. Every time I had to get up and relieve my bladder (and that was very often) I did the first section of the form and the pain was also relieved. The birthing process turned out to be an emergency caesarian section, partially, the doctor said, because my daughter was so big. After that shock it was time to do t’ai chi again. The medical professionals were surprised to find me standing and moving around and were amazed at my quick recovery and my ability to care for my infant even so immediately after major surgery

Shortly after my daughter’s birth weDoug,

This note is just to confirm my voicemail message this morning  indicating
that the charges for the Fuel Oil sample check for vanadium should be charged
to Co# 0413, RC # 106230.  According to the spec sheet I have, the ASTM
method for vanadium is D3605 and the units of measurement are ppm (wt).

Again, I appreciate your patience in this frustrating issue.

Charlie


a composite, are applicable in the various display devices. Quantum dots (hereinafter, also referred to as semiconductor nanocrystal) may be used as a light conversion layer in a light emitting diode (LED) or the like by dispersing in a host matrix of an inorganic material or a polymer. When a quantum dot is synthesized as a colloidal solution, the uniform particle size may be relatively easily controlled. When a quantum dot has a size of less than or equal to about 10 nanometers, the quantum confinement effects, in which the bandgap is increased with the decrease in a QD size, become significant, and thus the energy density is enhanced. The theoretical quantum efficiency (QY) of the quantum dot may be 100% and the quantum dot may emit light  { "bVisible": true, "bSearchable": true, "bSortable": true }
                ]

    });
          //This function works completely fine if the table is processed client-side,
          //I am not as successful on the server-side
        function table2xls(oTable, exportmode, tableElm){
            var xls = '';
            var headers = [];
            var rows = [];


          else $row[] = $aRow[$aColumns[$i]];

        }

        $output['aaData'][] = $row;
    }

    echo json_encode($output);
}

The ugliness of the above code has much to do with the fact that it was written in one sitting.

A:

It's working.But has bug about searching muti value.
You should my function replace it.
//function searching by Jacker & Krucamper myreadyweb.com.
    // Searching by Jacker & Kc.
    if(!empty($sSearch))
    {
        $str_query = '';
        $search_columns     = array();
              else
                {
                    $str_query .=  $value['columns']." REGEXP '".$value['keyword']."' ";
                }
            }
        }
        $str_query =  "( $str_query )";
        $this->db->where( $str_query, NULL, FALSE);
    }


There are ink compositions which are colorless and invisible under ordinary visible light but emit light and become visible in response to illumination of light at a specific wavelength such as ultraviolet light. In general, such an ink composition is called invisible ink. As a specific example of invisible ink, Japanese Patent Application Laid-Open No. 11-279474 (Patent Document 1) discloses an ink composition (see a chemical formula in FIG. 18) containing a fluorescent compound of arylsulfonic acid and tertiary amine.
An application of invisible ink is disclosed in Japanese Patent Application Laid-Open No. 2003-296659 (Patent Document 2) as a method of downloading information from a server on a network using a QR code as a kind of two-dimensional bar code written in invisible ink. According to an embodiment described                float32 1)
    form.Paint.Add(fun e -> drawCurve e.Graphics)
    form.Show()

draw_connected unit_circle ([0.0 .. 0.01 .. 1.0])

I am not entirely satisfied because I have to manual "scale" the x and y coordinates by 50 to make the circle visible. Is there a way to get F# do the scaling automatically?
Thanks.

A:

I think the code is representing a 2D point as a function taking 3 args - a flag, x & y. The flag indicates which of x and y to return. It would make (slightly) more sense for a start if the flag was a bool rather than a float. I'm guessing the code has been


converted from another language which only has floats?
Here's a slightly more comprehensible version:
open System
open Microsoft.FSharp.Collections
open Microsoft.FSharp.Math
open System.Drawing
open System.Windows.Forms
open System.Threading

type Point = {x : float; y : float}

let unit_circle (angle : float) =
    {
        x = (sin <| 2.0 * Math.PI * angle)
        y = (cos <| 2.0 * Math.PI * angle)
    }

let draw_connected (curve : float -> Point) (radius : float) (angles : float list) =
    let form = new Form(Text = "Curve")
    let drawCurve (gfx : Graphics) =
        for angle in angles do
          variant of the A8, with a higher clock speed (1.5GHz vs. 1.4GHz), a larger L2 cache (2MB, up from 1MB) and 2GB of external DDR3. It also uses an internal metal heatspreader, which the Apple A8 eschews. All of this points to slightly higher power consumption for the core, but also to dramatically increased performance. The new A8X is a significant power house in multiple types of workloads; in fact, its the top-performing mobile device on Geekbench by a wide margin. Gaming benchmarks are equally impressive. The iPad Air 2 nudges out Nvidia's Shield in GFXBench's Manhattan offscreen test, at 32.4fps to 31 fps. Onscreen favors the NV solution thanks to its lower-resolution screen, but the Nvidia device does take 3DMark Ice Storm Unlimited by a wide margin,


clocking in at 30,970 compared to 21,659.

Posted
by
samzenpuson Sunday October 05, 2014 @11:34AM
from the all-the-better-to-track-you-with dept.

wabrandsma writes From WinBeta: "One of the more interesting bits of data the company is collecting is text entered. Some are calling this a keylogger within the Windows 10 Technical Preview, which isn't good news. Taking a closer look at the Privacy Policy for the Windows Insider Program, it looks like Microsoft may be collecting a lot more feedback from you behind the scenes. Microsoft collects information about you, your devices, applications and networks, and your use of those devices, applications and networks. Examples of data we collect include your name, email address, preferences and interests; browsing, search and file history; phone call and SMS data; device configuration and sensor data; and application usage."four objects in one go?
Also, can I do this without accepts_nested_attributes_for?

A:

After some playing about with varied locations for square braces and different for loops, I think I've solved this. Here's what my code looks like now (with routes set up as per scaffolding, so that posting from /new triggers create).
models/person.rb
class Person < ActiveRecord::Base
  has_many :foos
  validates_presence_of :name
end

models/foo.rb
class Foo < ActiveRecord::Base
  belongs_to :person
  validates_presence_of :colour
  validates_uniqueness_of :colour, :scope => "person_id"
end

controllers/people_controller.rb
def new
  # Set up a Person with 3 defaulted Foos
  @person = Person.new
  (1..3).each { |i| @person.foos.build }
end

def create
  # Create (but don't save) a Person as specified
  @person = Person.new(params[:person])

  # Create (but don't save) a Foo for each set of Foo details
  @foos = []


bunch of orbs on the Queen Mary by the haunted pool. I believe.

I was running on my birthday through my neighborhood in Tucson in the middle of a school day almost six years ago. I saw what I thought was a soap bubble hovering about waist-high in the middle of the street. It seemed odd that it would be there, so I ran up to it and stopped to watch it. It appeared clear and did not have the prism of colors that you would see on a soap bubble in the sunlight. I could not see or hear that anyone was around. The bubble hovered for awhile--seemed almost to be observing me--then flew straight up about fifteen feet and then to my right over the roof of= 0.007].Conclusions: Our CTC panel showed high sensitivity and specificity in HCC diagnosis and could be a real-time parameter for risk prediction and treatment monitoring, enabling early decision-making to tailor effective antitumor strategies. Clin Cancer Res; 24(9); 2203-13. ©2018 AACR.


and C2 are determined from both the desired oscillation frequency and the predetermined ratio of C1 to C2, wherein the ratio C1/C2 is determined so as to ensure a stable oscillation of the oscillator circuit.
Second capacitor circuit 3 has capacitor 7 of capacitance C3 and switch 8 for connecting capacitor 7 in parallel to or disconnecting it from the tank circuit.
The tank circuit is connected between gate line 11 and the ground potential.
The bias potential for the gate line 11 is supplied from the junction of two voltage-dividing resistors 15 and 16 connected in series between voltage source VDD and the ground potential.
FIG. 2 illustrates the constitution of the Colpitts oscillator circuit shown in FIG. 1: (a) the basic circuit; (b) the equivalent circuit.
Since the transistor amplifier isthis book as my dream for you.

My goal in doing so is for you to not feel guilty when you occasionally eat chocolate hazelnut spread straight from the jar – and to move your body the way you want, to freely reach for your dreams and to tell yourself you are beautiful every day. I want you to **want** to love yourself in the deepest way possible and I'm here to guide you along the way.

As a health coach, personal trainer, mum, model, television host and ordinary woman living in a modern world, I have been blessed to ride a huge wave of self-discovery, and I've been lucky enough to learn unique lessons about who I am and to work with mentors who have shown me how to


framework of your life – the type you have known since the first day of school and who were there to provide a shoulder to lean on and helped you move house after that bad break-up, then organised your kitchen tea when you were marrying the love of your life.

The first thing I think about when the idea of proteins pops up is muscles, baby! That's because proteins provide the building blocks for cells and help maintain their structure. But there's more! Here's what you'll be getting from your serving of this marvellous macronutrient:

**1.** Regulation – of body function and overall functionality.

**2.** Satisfaction – the amino acids that form proteins are quite complex in comparison to carbohydrate molecules, for example, and require more time and energy to digest,of breath to have a conversation with someone.

2. Feel your run

I like to run according to how I feel, and on days I'm feeling more energised, I increase the pace. The running track is a great place to clear your head and get the creative juices happening. So if you're experiencing a block in any part of your life, getting outside and hitting the pavement can help create a shift and get the thoughts flowing. There has been lots of research on the positive effects of running on anxiety and depression, too. You'll be amazed at how good you feel even after a 15-minute run.

3. Focus on your form

If you're running for the first time, think about what your body is doing – keep your shoulders down and


and liken it to a shambling, murderous corpse-man, congratulations. You're making language!

#5. Riffage

Slightly more annoying than making nouns into verbs for no reason ("hold on, I'm Twittering!") is the trend of pluralizing them with "age." No need to say "make love" when "humpage" will do just as well. And, hell, we can label all fire alarms with "Fuck, burnage!" to make it that much clearer to everyone.

#4. Bouncebackability

While resilience is already a perfectly good word that means the exact same thing, bouncebackability does sound much more like something a semi-literate alcoholic might put on a resume, giving it that added appeal of mouthbreathability words like resilience lack.

#3. Prebuttal

The sad part about this one is that it only sounds completely insane until you realize it's mostly done by politicians,Warcraft, it's a sad day for the species when what you may recognize as that in which everything exists, needs a special term to differentiate it from the "real" world of Facebook friends and LOLcats.

Soon you'll hear it used in sentences like, "So all of the crops are dying and the air is turning poisonous? Bah, who cares about all that stuff that happens in lame old Meatspace."


Precise Treatment System™ linacs did not confer an advantage to the company during equipment evaluations, as National Health Service (NHS) guidelines for major procurements require that centers evaluate the solutions of all relevant providers, Hart notes.

"Only Elekta was able to offer that single workstation for the operator, which the others claimed to have but, in reality, did not," he says. "That meant that Elekta presented a total solution that included workflow and oncology information management, as well as the Elekta Synergy treatment systems and treatment planning with Monaco®."

MOSAIQ oncology information system went clinical at Nottingham in June 2010, followed by the Elekta Synergy systems with SYNERGISTIQ in October and November.

Nottingham University Hospital is First U.K. User of Elekta's Electronic Medical Record Workspace for Image Guided Radiation Therapy

From singleworkstation, U.K. center coordinates advanced IGRT therapy for patients with cancer

NOTTINGHAM, England, March 15, 2011 /PRNewswire/ -- Delivering Image Guided Radiation Therapy (IGRT) effectively and safely involves careful coordination of sophisticated systems, such as the therapy machine and its imaging subsystems, as well as theelectronic medical record (EMR) used to schedule and record patient treatments. Clinicians at Nottingham University Hospital are piloting their new IGRT program with SYNERGISTIQ™, Elekta's workflow management system for Elekta Synergy® linear accelerators. Nottingham's Radiotherapy Services Manager, Russell Hart, reports that SYNERGISTIQ is streamlining IGRT by orchestrating MOSAIQ® EMR and Elekta Synergy activities from a single workstation.

"The cone beam CT capabilities provided by the two Synergy systems we acquired are new to this department," Hart says. "Given that, and looking at the high potential


of all relevant providers, Hart notes.

"Only Elekta was able to offer that single workstation for the operator, which the others claimed to have but, in reality, did not," he says. "That meant that Elekta presented a total solution that included workflow and oncology information management, as well as the Elekta Synergy treatment systems and treatment planning with Monaco®."

MOSAIQ oncology information system went clinical at Nottingham in June 2010, followed by the Elekta Synergy systems with SYNERGISTIQ in October and November.

No comment

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Power andThe present invention relates generally to shutoff valves for liquid sprayers such as those used for insect control or lawn and garden use. In particular, the invention relates to valves that do not require a spring to hold the valve closed.
In the 1980's, H.D. Hudson Manufacturing Company developed a successful springless shut-off valve for liquid sprayers. In that sprayer valve, as explained in U.S. Pat. No. 4,933,569, the liquid travelled through a special reciprocating pin that was mounted for axial movement within a new valve body.
The valve body had a front section and a rear section. The front section had a downstream bore that communicated with a liquid nozzle. The rear section of the valve body had an upstream bore that could be attached to a liquid supply


bore, into the inlets, through the central passage, into the downstream bore, and then to the nozzle. In the closed position, the fit between the first upstream section of the pin and the first part of the upstream bore blocked the flow of liquid, with the second seal helping to prevent leakage.
A user moved the pin from the open position to the closed position by rotating a lever that was pivoted against an internal, upstream-facing shoulder in a radial groove in the chamber opposite the recess. The arm of the lever had a u-shaped notch with detents that engaged the waist of the pin, sliding across pin as the lever was pivoted and converting that rotational movement of the lever into linear movement of the pin.spectra were recorded under an electron ionization energy of 70 eV within an m/z range of 10--500. The ion source temperature was 230 °C.

PM~2.5~ collection, analysis and preparation procedure
------------------------------------------------------

PM~2.5~ was collected with PM~2.5~ high volume air sampler (Thermon Anderson, USA) using ultra fine quartz fiber filters (General Electric, USA) at a flow rate of 68 m^3^/h for 24 h per day from January to March 2013 in Langfang (Hebei, China). Organic and element carbon was detected by RT-4 carbon analyzer (Sunset Lab, USA). Water soluble ions were measured by ICS-2000/ICS-5000 ion chromatograph (Dionex, USA). The element composition of PM~2.5~ was detected by PE-SciexDR II inductively Coupled Plasma Mass spectromete (PerkinElmer, USA) and PAH was detected by Scion TQ gas chromatograph-mass spectrometer (Bruker Daltonic, USA). The filters were dried (24 h at 50 °C) and


([Fig. 3C](#f3){ref-type="fig"}). P2X7 displayed remarkable increases on day 7 and day 14 ([Fig. 3E](#f3){ref-type="fig"}), moreover, NLRP3 inflammasome just showed a distinct increase on day 7 ([Fig. 3D](#f3){ref-type="fig"}). We also detected TLR4 and NLRP3 protein expression in lung tissues by Immunohistochemistry. As shown in [Fig. 3F and G](#f3){ref-type="fig"}, PM~2.5~ significantly increased TLR4 and NLRP3 protein expression at all three time-points, especially at bronchus. These data provided basis for the hypothesis that TLR4/MyD88 pathway and NLRP3 inflammasome might be activated to generate IL-1β in PM~2.5~-induced acute lung inflammation.

CEOs may contribute to suppressing PM~2.5~-induced acute lung inflammation
--------------------------------------------------------------------------

At present, there is no effective treatment for the respiratory and circulatory diseases induced by PM~2.5~. EOs have been deemed to have anti-inflammatory, antifungal and antinociceptive properties in various pulmonary diseases, including pneumonia and lunginflammasome.\
mRNA levels were assayed by real-time RT-PCR using the ΔCt method. GAPDH was used as loading controls for mRNA expressions. CEOs downregulated mRNA expression of TLR4 (**A**), MyD88 (**B**), Nf-κB (**C**), NLRP3 (**D**) and P2 × 7 (**E**) of lung tissues. Data are expressed as mean ± standard error of the mean (\*\**P* \< 0.01, \**P* \< 0.05 versus the PM~2.5~ + saline group). CEOs reduced TLR4 (**F**) and NLRP3 (**G**) protein expression in lung tissues at all time-points, especially at bronchiole section.](srep44256-f6){#f6}

![CEOs reduced T-bet, GATA3, ROR-γt and Foxp3 mRNA expression of spleen tissues and IFN-γ and IL-4 protein expressions of serum.\
mRNA levels were assayed by real-time RT-PCR using the ΔCt method. GAPDH was used as loading controls for mRNA expressions. CEOs significantly reduced expression of the key transforming growth factors of Th1 (**A**), Th2 (**B**), Th17 (**C**)


Patterns of resource use within a population of xanthid crabs occupying bryozoan colonies.
Heads, i.e. colonies, of the bryozoan Schizoporella pungens are discrete resource units which protect the xanthid crab Pilumnus sayi from predation. The heads were spatially clumped, temporally stable, and differed both qualitatively and quantitatively. The number of adult P. sayi was equal to the number of heads with preferred characteristics, yet a relative shortage of this resource is suggested with concomitant intraspecific competition. Adult crabs occupied heads individually except for infrequent cases of double occupancy by a male and female. Further spatial pattern among crabs was consistent with a hypothesis that males defend clumps of heads occupied by females.in the impressive outing. He also notched eight strikeouts, giving him 126 through 114 innings this season.

"I'd say being able to throw my slider for strikes and just getting them off my fastball a little bit [was key]," Cody told MiLB.com. "I was able to execute a few changeups as well. It was all working through the middle innings, through the fourth, fifth and sixth. I just kept the hitters off-balance and the defense did a nice job behind me. And that's all I can really ask for."

• Rockies No. 18 prospect Tyler Nevin set a couple of career highs as he collected five hits and scored four runs in Class A Asheville's win over Lexington. Nevin finished a homer shy of the cycle, but was still a


some initial sensitivity (adaptive resistance), or acquire resistance after relapse \[[@CR10]\]; for example, one-quarter to one-third of patients with melanoma exhibit relapse and do not respond well to treatment (Table [1](#Tab1){ref-type="table"}) \[[@CR11]\]. Accordingly, resistance is a major limitation of anti-PD-1 therapy in clinical practice. To facilitate precision medicine and burden reduction in patients, we provide examples of curative effect biomarkers and resistance mechanisms against anti-PD-1 therapy. We further discuss combined treatments with the potential to improve efficacy. Table 1Representative FDA-approved immunological checkpoint inhibitorsGeneric nameTrade nameTargetApplicationpembrolizumabKeytrudaPD-1melanoma, non-small cell lung cancer, head and neck squamous cell cancer, classical Hodgkin lymphoma, primary mediastinal large B-cell lymphoma, microsatellite instability-high cancer, gastric cancer, cervical cancer, hepatocellular carcinoma, Merkel cell carcinoma, renal cell carcinoma, urothelial carcinomanivolumabOpdivoPD-1metastatic small cell lung cancer, metastatic melanoma, metastatic urothelial carcinoma,CD8^+^ T cells, and promote TIL infiltration to improve the efficacy of anti-PD-1 in patients with melanoma \[[@CR78], [@CR80]\]. Progression-free survival and OS in the antibiotic treatment group were significantly shortened in advanced NSCLC, RCC, and urothelium carcinoma treated with PD-1/PD-L1 monoclonal antibody-based biotherapeutics \[[@CR80]\]. The intestinal microbiome regulates the response to anti-PD-1 therapy, but the expression of PD-1 also affects the composition of the intestinal microbiome \[[@CR81], [@CR82]\]. Gastrointestinal immune-related adverse events, a common complication of anti-PD-1 therapy, disrupt the intestinal microbiome, which can lead to drug resistance \[[@CR83], [@CR84]\]. Routy et al. found a positive correlation between *Akkermansia muciniphila* and the efficacy of PD-1/PD-L1 blockade in lung cancer and RCC, and a positive response to immunotherapy in mice given oral bacterial supplementation \[[@CR80]\]. Further research should


focus on the detection of microbial taxa in the gastrointestinal tract with predictive value for anti-PD-1 responses and the use of fecal transplantation as an adjunct therapy.

Mechanism underlying resistance to PD-1/PD-L1 blockade {#Sec8}
------------------------------------------------------

### T cell dysfunction-mediated resistance {#Sec9}

Various processes, including recognition, activation, differentiation, and chemotaxis, are needed for T cells immune function. The disruption of one or several of these processes leads to T cell dysfunction and tumor immune escape. First, initial T cells must successfully identify tumor antigens presented by APCs. Next, the activation of primary T cells requires the antigen-MHC complex and the binding of B7 and CD28 on the cell surface, providing an important second signal. Finally, differentiated T cells migrate to specific tissues to perform immune functions and contribute to PD-1 blockade therapy resistance.

###to a decreased immunotherapeutic response \[[@CR91]\]. TNF is essential for the expression of TIM-3 in TILs, and its compensatory expression is upregulated after blocking PD-1, thereby inducing TIM-3 expression \[[@CR92]\]. In melanoma, anti-PD-1 treatment also increases the inhibitory immune checkpoint, VISTA, that synergistically inhibits T cell activation with PD-L1, leading to adaptive resistance; its expression is higher than that of PD-L1 in CRC \[[@CR93]\].

Furthermore, changes in specific genes can also cause T cell activation disorders. Up to one-third of melanomas are accompanied by PTEN deletion, for which the mechanisms include gene mutations and deletions, loss of chromatin, loss of heterozygosity, and epigenetic changes such as hypermethylation-induced transcriptional silencing \[[@CR94]--[@CR100]\]. PTEN itself negatively regulates the PI3K/AKT pathway and down-regulates PD-L1 expression. In melanoma, PTEN deletion promotes AKT phosphorylation, thereby


have found that NTRK is upregulated by anti-PD-1 therapy. NTRK abnormally activates the JAK-STAT signaling pathway, upregulates the expression of multiple inhibitory receptors on T cell surfaces, including PD-1, and promotes T cell depletion \[[@CR117]\]. Tregs also promote the expression of CD8^+^ T cell depletion-related gene expression via IL-10 and IL-35. Sawant et al. found that IL-10 regulates the STAT pathway and IL-35 regulates the STAT1\\4 pathway, further altering the expression of BLIMP1 and its target genes. BLIMP1 enhances the expression of inhibitory receptors in T cells and promotes T cell depletion (Fig. [5](#Fig5){ref-type="fig"}) \[[@CR118]\]. Fig. 5T cell exhaustion causes PD-1 blockade therapy resistance. PD-1 blockade promotes the secretion of cytokines, including IFN-γ and TNF, leading to the expression of ligands of inhibitory receptors, including LAG3 and TIM-3, indue to JAK1/JAK2 inactivation mutations, leading to recurrence, has been found in a small number of patients \[[@CR87], [@CR119]\]. Patients with JAK1/2 mutations can develop drug resistance, irrespective of TMB \[[@CR124]--[@CR126]\]. JAK1/2 regulates the chemokines CXCL9, CXCL10, and CXCL11 \[[@CR127]\]. Deletion of the tumor suppressor CDKN2A, one of the most frequently lost tumor suppressor genes in human cancers, increases the likelihood of JAK2 deletion and resistance to immunotherapy \[[@CR128]\].

Many factors lead to the adaptive up-regulation of PD-1 and drug resistance. In a mouse model of KP mutant lung cancer, neurotrophic tyrosine receptor kinase 1 (NTRK1) expression increased significantly after treatment with a PD-1 inhibitor, and NTRK1 promoted abnormal JAK1 and STAT3 activation. Excessive JAK/STAT pathway activation leads to PD-L1 up-regulation \[[@CR117]\]. In NKT cell lymphoma, after PD-1 blockade,


changes contribute to resistance. Mutations in the *JAK* and *EGFR* genes result in the loss of PD-L1 expression, affecting antigen presentation. The lack of CXCL9, 10, and 11 expression prevents T cell chemotaxis in the tumor microenvironment, causing primary resistance. After PD-1 blockade, adaptive changes in various genes alter tumor cell metabolism, reduce MHC expression, and upregulate PD-L1, resulting in the inhibition of T cell activity and adaptive resistance

Combination therapy to improve the efficacy of PD-1/PD-L1 blockade {#Sec15}
------------------------------------------------------------------

Based on the aforementioned mechanisms underlying resistance to PD-1 blockade therapy, we explore candidate targets for combined PD-1 immunotherapy, providing new hope for improving the therapeutic efficacy through increasing T cell proliferation and enhancing immune cell function.

### Combination therapeutic strategies to enhance T cell activation {#Sec16}

Two strategies can enhance T cellmethod for pre-treatment tumor TIL testing, comprising a visual assessment of H&E stained sections \[[@CR188]\]. Although it has limitations in macrophage detection, it has been widely used in many clinical applications. Furthermore, more practical predictive indicators, such as microbial taxa in the intestines, should be identified in addition to the development of accurate detection methods.

Furthermore, the development of research and detection methods for molecular markers in the blood is of considerable significance because the extraction of peripheral blood for detection has the advantages of being simple and easy to perform and less invasive to the patient. This is an advantage that traditional pathological examinations do not have and should be focused on.

In general, the precise mechanisms underlying drug resistance to PD-1 treatment and appropriate therapeutic strategies are still


exosomes can inhibit tumor progression by promoting antigen presentation and regulating immune function. However, studies are currently focusing on its impact on tumor progression; therefore, the study of exosomes must be more comprehensive \[[@CR2]\]. To detect changes in PD-L1 expression and guide precision medicine, more accurate detection methods are needed \[[@CR189]\]. More generally, the membrane and exosome expression of PD-L1 should be dynamically monitored. In addition to the effects of PD-L1 expression on drug resistance mechanisms, it has recently been discovered that certain molecular targets already used in cancer treatment also affect the efficacy of immunotherapy, leading to the development of resistance to PD-1/PD-L1 blockade therapy. In addition to TNF-a and IFN-γ mentioned above, there are many inflammatory factors, including IL-6, IL-17, and EGF, that play an importantmolecules, immune cells, and effectors. The role of any single pathway cannot be considered in isolation.

In addition to immune checkpoints and immune system activity, synergistic treatment approaches, including strategies to activate tumor cell autophagy, inhibit tumor angiogenesis, and inhibit mesenchymal transition, can also improve the efficacy of PD-1/PD-L1 blockade therapy. We should broaden our thinking to the perspective of the tumor itself, e.g., inhibiting nutrient supply, growth, and metastasis, and consider combined approaches with immunotherapy to achieve better results.

Conclusions {#Sec20}
===========

Despite the success of PD-1/PD-L1 treatment, its practical application is still limited. To determine whether a patient may benefit from anti-PD-1 treatment and reduce the burden on patients, PD-1/PD-L1 expression and predictive indicators should be dynamically monitored throughout the treatment process. Established prediction molecules are still insufficient, and improved


103.5 to its collection, though a new radio station, "Washington Post Radio", took over WTOP's previous frequencies on March 30, 2006. The previous occupant of 103.5, the classical music station WGMS, was moved to the Z104 frequencies. The final full song played on "Z104" was "Soul To Squeeze" by Red Hot Chili Peppers. The opening lyrics of "I Will Remember You" by Sarah McLachlan were then played, but the song was cut off by General Manager Joel Oxley announcing the changes, thanking the staff and listeners, and, in a rare move, redirecting former listeners to competing stations in the area.

One year later, WGMS was shut down (with the music library donated to WETA.) The 104.1 frequency for a short period aired a Jack FM-style variety hits format ascenter
        2.1.4 if turning from outer to center
    2.2 decide what is the most efficient solution
3. store this result
4. subdivise the area in 2 smaller rectangles
5. redo the same thing for the 2 and test various combination for the travel from rectangle 1 to 2 (obviously the starting pos on 2 is free) Always keep track that anything bigger than the cost of the first solution can be ignored

If I could give a simple guess, that is not mathematically the fastest, but a good solution
is what most AOI do, just do the biggest rectangle.
The problem mathematically depends on a lot of variables, if t is important (often true for robots) then the simple solution is probably close


different hurt – and I noticed that the veins were no longer retracted but distended like worms, it burned, my eyes bothered me a lot, and reverted back to the former state of coldness. My 7 week old hypergranulated wound on my foot also weeps with more circulation. Heart rate changing up, yadda yadda.

The funny thing, is that the cold bottom portion of my body doesn’t match the normal temperature of the top – WITH THE EXCEPTION OF PERSPIRATION UNDER MY ARMS! What the heck!!! Really!! That’s 3 different, unsynchronized regions of my body – and that’s only for temperature!

My legs and back are awful so I’m going to refrain from writing. Sad, because the writing is theraputic for me. I’m not sure what else I’ve ‘done wrong’Q:

Xcode autocomplete does not work in Sources folder of Swift playgrounds

I am working on a Swift playground that contains multiple files in the Sources folder alongside the main file. When I type something, for instance, "UI", in the main file, I get the expected autocomplete suggestions. However, when I do the same in files in the Sources folder, I get a "dumb" autocomplete menu as seen in this question: Xcode 9 Autocomplete Not Working 100% - Partially Working
I have tried deleting DerivedData as suggested in the above question, and have even gone to the lengths of reinstalling Xcode entirely. However, the problem has not gone away. I have created a new playground to ensure it is not specific to this project, and the same problem occurs.
Edit: I just


and diversity. The relative abundance of bacteria closely related to the resistant of heavy-metal was markedly increased, while the bacteria related for carbon/nitrogen/phosphorus/sulfur cycling wasn't strikingly changed. Besides that, the pathogenic bacteria markedly increased in the downstream rhizosphere soil since reclaimed water supplement, while the possible plant growth-promoting rhizobacteria obviously reduced in the downstream sediment. Together these data suggest cause and effect between reclaimed water input into the wetland, shift in bacterial communities through habitat change, and alteration of capacity for biogeochemical cycling of contaminants.Software packages, such as complex software systems, provide a wide variety of functionality for use by their customers. Sometimes, a software package may provide all of the functionality that a user needs to accomplish a specific task. However, in the case of large or complex software systems, such as enterprise resource planning (ERP) systems, the customer often needs to customize the software system to meet the customer's needs.
In order to customize a large or complex software system, a user may have to create a new extension that operates independently of the software system. The new extension may include custom programming related to custom user interfaces, custom data access procedures, custom data processing routines, and other types of custom programming. The new extension may be difficult to integrate into


frame = readFrame()
        frame = obj.reader.step();
 end
  function [centroids, bboxes, mask] = detectObjects(frame)

        % Detect foreground.
        mask = obj.detector.step(frame);

        % Apply morphological operations to remove noise and fill in holes.
        mask = imopen(mask, strel('rectangle', [3,3]));
        mask = imclose(mask, strel('rectangle', [15, 15]));
        mask = imfill(mask, 'holes');

        % Perform blob analysis to find connected components.
        [~, centroids, bboxes] = obj.blobAnalyser.step(mask);
  end
function predictNewLocationsOfTracks()
   20;
        [assignments, unassignedTracks, unassignedDetections] = ...
            assignDetectionsToTracks(cost, costOfNonAssignment);
end
 function updateAssignedTracks()
        numAssignedTracks = size(assignments, 1);
        for i = 1:numAssignedTracks
            trackIdx = assignments(i, 1);
            detectionIdx = assignments(i, 2);
            centroid = centroids(detectionIdx, :);
            bbox = bboxes(detectionIdx, :);

            % Correct the estimate of the object's


reliableTrackInds = ...
                [tracks(:).totalVisibleCount] > minVisibleCount;
            reliableTracks = tracks(reliableTrackInds);

            % Display the objects. If an object has not been detected
            % in this frame, display its predicted bounding box.
            if ~isempty(reliableTracks)
                % Get bounding boxes.
                bboxes = cat(1, reliableTracks.bbox);

Default 30
        myVideo.Quality = 75;    % Default 75
        open(myVideo);

        for i = 1:length(tracks)

            writeVideo(myVideo, mask);
            obj.maskPlayer.step(mask);
           % obj.videoPlayer.step(frame);
          %  pause(1);

        end
        close(myVideo);

        % Display the mask and the frame.
        obj.maskPlayer.step(mask);


   obj.videoPlayer.step(frame);
        pause(1);
        %saveas(fm1,'g.jpg')
end
end

A:

There is indeed too much code here. You did not have to paste the entire program.
One problem that I can see is that you have a loop over the number of tracks, and you write a frame to a video file for each track, which is wrong. You should be writing a frame to a video file only once per each iteration of the main loop.
If all you want is to create a video with the bounding boxes around tracked objects, you should write each frame with the annotations to the video file right after the call to insertObjectAnnotation.

(b) 0.1  (c) -356
c
Suppose 4*v + 18 = -h, v = 4*h + 6*v + 17. Let c = 0.03 - -0.47. Let g = -1.5 + c. What is the smallest value in 1/6, h, g?
g
Let l = 0.1 + -0.59. Let i = -0.09 - l. Let w = 4 + 3. What is the second smallest value in i, -2/3, w?
i
Let s be ((-9)/60)/(3/(-6*2)). Let m = 313 + -2813/9. Which is the second smallest value?  (a) s  (b) 6/7  (c) m  (d) -2/5
c
Let o be (4724/11910)/((-20)/(-30)). Let x = o + 2/397. Suppose -6*n + n - 18 = i, 5*i = -15. What is the third biggest value in n, -5, x?
-5
Let k = 1.398 + -1.698. What


5*p + 60. What is the third biggest value in p, -6/11, -2/13?
p
Let k = 566 - 566.3. Let i = 7/12 + -1/4. Which is the second biggest value?  (a) k  (b) 0.3  (c) -0.4  (d) i
b
Let y(u) = 4*u**2 + 261*u - 175. Let w be y(-66). Suppose 2*l - 6 = 0, -3*l + 13 = -3*z + 2*z. Which is the third biggest value?  (a) w  (b) z  (c) 2/7
b
Let w = 0.09 - 5.09. Let g be ((-9)/132)/(4 + 80950/(-20236)). Let p = -230 + g. Which is the third biggest value?  (a) w  (b) p  (c) -3
a
Let f be -1 + -5*(-8)/100. What is the second biggest value in -11/6, f, -2?
-11/6
Letvisualized by enhanced chemiluminescence reagents (GE Healthcare). The experiments were repeated at least three times.

2.6. Bleomycin‐induced pulmonary fibrosis mouse model {#jcmm14793-sec-0008}
-----------------------------------------------------

Six‐week‐old male C57BL/6 mice were purchased from Dae‐Han Laboratory Animal Research Co. (Daejeon, Korea) and housed at 50 ± 10% humidity and 22 ± 2°C with free access to sterile food and water. After acclimatization for 1 week, the mice were randomly distributed into experimental groups (n = 5). The mice were anesthetized with ketamine (100 mg/kg) and xylazine (10 mg/kg), and then intratracheally administered an instillation of 100 mg/kg bleomycin (BLM; Nippon Kayaku Co.) through a 27‐gauge needle.[19](#jcmm14793-bib-0019){ref-type="ref"} IM‐1918 (2 mg/kg) or vehicle (0.1% dimethyl sulfoxide) was intraperitoneally injected every other day, starting on day 1 after BLM treatment. On day 14 after BLM administration, the mice were sacrificed, and the harvested lungs were subjected to immunohistochemical analysis


and western blotting. All animal experiments were approved by the Institutional Animal Care and Use Committee of the Korea Institute of Radiological and Medical Sciences.

2.7. Histological analysis and immunohistochemical staining {#jcmm14793-sec-0009}
-----------------------------------------------------------

The lung tissues were fixed in formalin for 24 hours and embedded in paraffin (Hayashi Pure Chemical Industries). Left lung tissue sections (3 µm) were cut and stained with haematoxylin and eosin or Masson\'s trichrome for histopathological examination and evaluation of collagen accumulation. The dewaxed sections were exposed to 3% H~2~O~2~ for 10 minutes to block endogenous peroxidase activity, followed by incubation with primary antibody against α‐SMA for 60 minutes at room temperature using a Cap‐Plus kit (Zymed) according to the manufacturer\'s protocol. The sections were then incubated with the biotinylated secondary antibody for 40 minutes, and streptavidin conjugate successively for 30 minutes atdensitometry using ImageJ software, normalized to β‐actin or the total form of each protein, and expressed as the fold‐change compared to each control. Data were considered significant at \**P* \< .05, \*\**P* \< .01, \*\*\**P* \< .001 vs control; ^†^ *P* \< .05, ^††^ *P* \< .01, ^†††^ *P* \< .001 vs BLM](JCMM-24-830-g005){#jcmm14793-fig-0005}

![Schematic model for anti‐fibrotic activity of IM‐1918. TGF‐β is a well‐known mediator that promotes the fibrotic process via Smad‐dependent and Smad‐independent pathways. Treatment with bFGF also induced activation of fibrotic molecules, in co‐operation with TGF‐β1. IM‐1918 prevents phosphorylation and activation of FGFR3, leading to attenuation of the fibrotic process in vitro and in vivo](JCMM-24-830-g006){#jcmm14793-fig-0006}

4. DISCUSSION {#jcmm14793-sec-0017}
=============

TGF‐β is a major causative factor of symptoms of fibrotic diseases and multifunctional cytokine that plays various roles in the body.[12](#jcmm14793-bib-0012){ref-type="ref"} In this study, the novel compound IM‐1918 effectively suppressed the expression of


count as influential. Based on Politico’s January 2017 listing of White House staff, we identified 19 influential new positions in the Trump administration and added those to the Trump A Team. These included the most senior titles — assistants to the president and deputy assistants to the president — that had not previously been listed by National Journal, such as Stephen K. Bannon, chief strategist and senior counselor to the president.

From that list, I determined Trump staff turnover, defined as any staff movement — whether from resignation, promotion or firing.

There was a lot of churn in the Trump administration

As shown in the figure below, the Trump administration witnessed record level turnover during Trump’s first year in office.

We can easily see several noteworthy trends.

First, President Trump’s A Team turnoveris significantly higher than any of his five predecessors. As of Jan. 12, 2018, 34 percent of the staff has left or changed positions, more than double the turnover in President Ronald Reagan’s first year and four times that in President Barack Obama’s. Some Trump staffers, like Reince Priebus were forced out; others, like Sarah Huckabee Sanders were promoted; and a few, like Paul Winfree, voluntarily resigned.

Second, much of the Trump turnover can be found in Tier 1. Of these 12 highest-level positions, Trump lost six, including chief of staff (Reince Priebus), deputy chief of staff, (Katie Walsh), press secretary (Sean Spicer), director of public liaison (George Sifakis), national security adviser (Michael Flynn) and deputy national security adviser (KT McFarland).

By contrast, Obama only lost one Tier 1 staff


5.22 billion Kenyan shillings as at December 28, 2012 (US$64 million at the exchange rate then).

Real Estate - First Chartered Securities real estate assets include Riverside Park and AMBank House, both in Nairobi.

Others - First Chartered Securities made forays into other sectors, including logistics, agriculture, milling and beverages. It owned Inchcape Shipping but sold its interests. It also had interests in catering firm Nairobi Airport Services (NAS), in which a French multinational, Servair, acquired a 59% stake in December 2012, estimated at more than Sh2.25 billion (US$26 million).

Personal life

Two of Philip Ndegwa's children became officials at NIC Bank and First Chartered Securities: James P. M. Ndegwa (Chairman of the Board), and Andrew S. M. Ndegwa (Non-Executive Director).

Death

Philip Ndegwa died on 7 January 1996. As a tribute, the Unitedand $[a,1]$. Each branch is surjective and $C^2$ when restricted to the interior of its domain ($(0,a)$ or $(a,1)$ respectively).

Example {#ex:alpha=1}
-------

Set $\alpha=\alpha^\prime =1,~c_0=c_1=1$ and $g_i \equiv 0$. Then $\phi(x)=1-x$ and $a=1/2$. The map $B$ is non-uniformly hyperbolic, with lines of fixed points along $\{x=0\}$ and $\{x=1\}$

The integrals defining $f$ in (\[eqn:map1\]) are easily computed, yielding $$f(x) = \left\{\begin{array}{ll} 1-\sqrt{1-2\,x}~~
        &\mbox{if $x<\textstyle{\frac{1}{2}}$},\\
        \sqrt{2\,x-1}&\mbox{if $x>\textstyle{\frac{1}{2}}$}.
    \end{array}\right.$$ We emphasize again that $f$ is a measure-preserving circle endomorphism on $[0,1)$ with a discontinuity in $f^\prime$ at the single point $a={1 \over 2}$, and a neutral fixed point at $x=0$, but in this case, with quadratic order of contact. Thus the example does not fit into


value of the return time function $R$ is the same on both intervals.

\[l:metric\] There exists a constant $\beta=\beta(f) <1$ such that if $x, y \in \Delta_0$ and $s(x,y)=n$ then $|x-y| \leq \beta^n$

Set $\beta := \min\left\{ [f^\prime(x_0^\prime)]^{-1},
[f^\prime(x_0)]^{-1}\right\} <1$ and observe that on the set $\Delta_0,~f^\prime \geq \beta^{-1}>1$, and hence $(f^R)^\prime\geq \beta^{-1}$ (recall $f^\prime\geq 1$ everywhere). Therefore, if $x,y$ lie in a common atom $\Delta_{0,i}^{(\prime)} \subseteq  (f^R)^{-1}[x_0,x_0^\prime]$ with $x= (f^R)^{-1}(x^\prime),~y=(f^R)^{-1}(y^\prime)$ then $|x-y|\leq \beta$. The result follows by induction on $i \leq n$.

\[l:distortion\] Let $y,z\in\Delta_0$ and suppose that $s(y,z)\geq 1$. Then there is a constant $D>1$ (depending on $f$ but not $y,z$) such that $$\left|\frac{{f^R}'(y)}{{f^R}'(z)}-1\right|\leq \frac{D\,(D-1)}{m(\Delta_0)}\,
|f^R(y)-f^R(z)|.$$

See Appendix 1.

\[rem:nonsingF\] The ambient measure $\mu_0$ from the abstract tower construction is chosen to be Lebesgue measure $m|_{[x_0, x^\prime_0)}$. Its lift to the towerto (a respective proxy call session control function within) the home telecommunications network, there is only the possibility to maintain a (normally huge) list of local emergency numbers (that are applicable or valid within the different telecommunications networks of all the possible roaming partners of the home telecommunications network) with a mapping to the related uniform resource names of the emergency call telephone numbers (also called sos-uniform resource names) in the local network node or the home telecommunications network (typically a proxy call session control function of the home telecommunications network). The maintenance of such a database for all roaming partners worldwide requires a considerable effort and—hence—is very costly.


he or she will not get the key generated by wireless device A 101 and thereby cannot access wireless device A 101.
The aforementioned way to establish an authenticated wireless connection between short-range wireless terminals is disadvantageous in the following two aspects.
First, in process (a), when wireless device B 102 searches the device ID list for a target device ID, the screen will display all the device IDs received by wireless device B 102 in the range of the short-range wireless communication, as shown in FIG. 2. This possibly brings about the following problems:
1. there are too many device IDs received in the range of the short-range wireless communication, resulting in an overlong device ID list which is disadvantageous in searching;
2. since the device ID is named by thethe animal has traveled into the corresponding place field \[[@pcbi.1005114.ref048]\] (see [Methods](#sec012){ref-type="sec"}). The effects of the *γ*-rhythm are, however, more diverse. Electrophysiological experiments suggest that there exist at least two types of place cells: "TroPyr" cells that spike at the trough of the fast *γ*-wave (50--80 Hz) and "RisPyr" cells that fire at the rising phase of slow *γ*-waves, overriding *θ*-precession \[[@pcbi.1005114.ref049]--[@pcbi.1005114.ref051]\]. Although we can model both [S2 Fig](#pcbi.1005114.s002){ref-type="supplementary-material"} with our approach (see [Methods](#sec012){ref-type="sec"}), in the following we will model only the TroPyr cells that exhibit more robust firing patterns and higher firing rates, and therefore may play a primary role in producing the cognitive map \[[@pcbi.1005114.ref029], [@pcbi.1005114.ref030]\].

### *γ*-modulation of spiking {#sec006}

Physiologically, the *γ*-wave represents fast oscillations of the inhibitory postsynaptic potentials. As the amplitude of *γ* drops


can be visualized as a point, *σ*^1^ as the ends of a line segment, *σ*^2^ as the vertices of a triangle, *σ*^3^ as the vertices of a tetrahedron, etc. \[[@pcbi.1005114.ref102]\]. A *clique* in a graph *G* is a set of fully interconnected vertices (i.e., a complete graph). Combinatorially, cliques have the same key properties as the abstract simplexes: any subcollection of vertices in a clique is fully interconnected, and hence forms a subclique. A nonempty overlap of two cliques $\varsigma_{1}^{d}$ and $\varsigma_{2}^{d}$ is a subclique in both $\varsigma_{1}^{d}$ and $\varsigma_{2}^{d}$. Therefore, cliques define abstract simplexes and thus the collection of cliques in a graph *G* defines a *clique simplicial complex* Σ~*ς*~(*G*).

Choice of the simulated environment {#sec014}
-----------------------------------

In \[[@pcbi.1005114.ref030]\] we showed that the time required to learn a large spatial165*p - 7 = 172*p. Let z be (0 - 2 - p)/1. Which is bigger: z or s?
s
Let h be 3/(6*19/(-25612)). Is h at least -664?
False
Suppose 5*y + 4*u - 12 - 18 = 0, 0 = -4*y + 3*u + 24. Suppose -37*k = -y*k - 2387. Are k and 75 equal?
False
Suppose 4*b - 2*i = -10, -5*b - 13 = -i + 4. Suppose -3*p - 17 = -y + 8, -4*p + 30 = 2*y. Let x = 15 - y. Is x <= b?
True
Suppose 0 = 3*i + 5*q + 2183, -2*q + 825 - 112 = -i. Let w = i - -5048/7. Does w = 2/3?
False
Let c = 226 + -328. Let o be 4/(-6) + c/9. Which is bigger: o


5*j + 734 = 0. Let y be (-638)/u + (-2)/(-3). Is -1 equal to y?
False
Let s(b) = b**2 - 5*b - 13. Let t be s(-2). Let d be ((-12)/(-148968)*4)/(t/3). Which is smaller: d or 0?
0
Suppose 0 = 35*d - 7*d + 28. Let z = -248 - -250.62. Let q = z - 2.5. Which is bigger: q or d?
q
Let n = -2909845/2506 + 8128/7. Which is smaller: n or 0phone call with the hospital I was in. I had real spacticity. It was really scary and painful. It was then like a hole body cramp, even in my head...My thumb in a totally weired position....But as always, it went away...today, there was nothing. Except very uncoordinated and heavy hands, due to muscle tension in my lower arms...Thank god, no twitching. Maybe one per day...but that seems in the range of "normal" to me ...so twitching went away with cortisone obviously...In hospital they now afraid of me having an infection (instead of ms or rheumatism), meaning virus. That is the same as my neuro thinks...

I put pressure behind diagnostics because I will excluce all possible deseases on my list. That's what my neuro recommended to me last appt..


very much reduced:High muscle tone: completely gone in the back lymphedema: completely gone after one year (this was my latest finding..did not realize in the beginning)muscle twitching almost goneclumsiness of hands: better (not gone)feelings of paraysis in hands/numb fingers: gonewalking disorder (diagnosed): almost gonepain in my lower arms/ellbows: after a strong flare up actually better

Chronic fatigure: slightly reduced. I would say I can climb the stairs some times more than before. But in general it is the heavy load

the spine MRI showed some throat spine prolapses touching the nerve routes, narrow spine channelm artrosis, but would not explain my symptoms completely.Skin biopsy: outcome still to come.The hospital neuros decided to continue with the cortisone 5 mg prednisolon. My neuro wants me to take Amantadin for my fatigue andgradually turn on each other is teased out brilliantly, with ruthlessly self-serving businessman Yong-suk (Kim Eui-sung) likely to top your list of cinema's nastiest bastards of 2016. In the same way, those who emerge as the heroes of Train To Busan do so authentically to deliver some of the most affecting scenes you're likely to witness in a horror film for quite some time.

Importantly, the emotional elements are not given prominence at the expense of the action; moreover, Yeon pushes himself to deliver increasingly impressive action as the film goes on, with some of the most breathtaking set pieces to be found during the final act. Just when you think the excitement, the tension and the scares are over, the director gives you more, never allowing himself to


progressed to the final. In the final, he lost to Marin Čilić of Croatia.

At the year's first Grand Slam, the Australian Open, Somdev was seeded 28th in singles qualifying. He beat Prakash Amritraj in his first qualifying round; then lost to unseeded Łukasz Kubot of Poland in the second round. After some poor results in qualifying and Challenger tournaments, Somdev had a successful Davis Cup campaign, winning both his matches against Chinese Taipei, including a critical reverse singles match against world no. 59 Yen-Hsun Lu to lead India to victory.

In the second Grand Slam of 2009, the French Open, Devvarman was seeded 26th in singles qualifying. He defeated João Souza of Brazil in the first round and ousted Brit Alex Bogdanovic before losing to third seed and worldthe singles gold medal in the 2010 Asian Games at Guangzhou, China by beating Denis Istomin of Uzbekistan in straight sets. The day before, he had teamed up with Sanam Singh to win the gold in the doubles event.[8] However, because tennis at both the Commonwealth Games and the Asian Games are not ATP tour events, Somdev did not gain any ATP ranking points.

Somdev started 2011 ranked at no. 108. He started the season with the Chennai Open, an ATP 250 tournament, and lost to qualifier David Goffin in the first round.

Somdev got a wild card to the 2011 Australian Open due to his good performance in 2010. Playing this tournament for the first time in his career, he lost to Tommy Robredo in the first round. Somdev


Then, he had a second-round match-up with Roger Federer, but he lost in straight sets,.

Devvarman made his Davis Cup debut for India in 2008 against Uzbekistan at the age of 22. In the second rubber of the tie Devvarman faced Denis Istomin and fell in straight sets. With the tie locked at two match victories each, Devvarman was substituted for countrymen Prakash Amritraj in the fifth rubber. Amritraj would be victorious in four sets. Devvarman would return to the team in the 2008 World Group Playoffs to face Romania. He would fall short in both his singles matches and keep India in the zonals for another year. India started 2009 by playing Chinese Taipei in the Asia Oceania Group 1 quarterfinal. India won 3–2 with a significant contributionbut it costs about $175 and it's white (I personally like the looks of the black tablets better).

I just checked Wacom's site, and there are 5 different Bamboo models. The normal Bamboo, Fun, and Craft models are all identical in sensitivity levels. The other two models, the Pen and Touch, aren't designed for graphic arts; the Pen is for handwriting and the Touch is basically a large navigational pad, like a laptop's touchpad...those two do not match the other three for sensitivity.

The pens for the Bamboo models do not appear to have interchangeable tips, at least as far as I could tell from the site (Wacom's site leaves a lot to be desired, IMHO). It does say that the writing surface feels like pen on paper...felt tip? ball


practical solution, according to which the pump is used from above in the container, the connecting rod is brought out from the container via a heat-insulated container neck. To further reduce the gas heat conduction, an insulating cartridge can be provided in the neck of the container. In addition, the container is advantageously vacuum-insulated.
According to an especially preferred embodiment of the invention, the pump cylinder of the reciprocating pump is divided by the plunger into a pressure side and an induction side, whereby the plunger has a plunger body as well as a movable plunger ring that is brought to rest on the plunger body when the plunger moves in the direction opposite the pressure stroke in such a way that a gap is formed that produces aextracted in an unbiased procedure from the BIOSTER database. The true bioisosteric pairs have been compared with pairs of random fragments originating from the WDI database. Normalized by the standard deviation of the random pairs distance distributions, an excellent separation of true pairs from random pairs was obtained for R-group fragments (2.2 standard deviation units) as well as for linkers (2.6 units) and cores (2.6 units). The bioisoster search method has been implemented as an intranet application called IBIS and is now routinely used by Organon researchers.


I've started programming on a different chip, one of the 33EV types. Goal is to have sensorless start with full torque at standstill. Relative (sensorless) position at standstill is quite easy, but to get absolute phase information requires a bit more doing. The picture above shows the different versions of analog signal processing that I am considering for processing the current sensor signals. The left one has 4 opamps, the right one 8 at the moment but should be 10... but have already scrapped that one in my mind and am drawing up schematic for version 3....

DSC02110-800x800.jpg (128.37 KiB) Viewed 2788 times

The new processor plugges onto the powerPCB. The analog bits plug into the bottom right header of the experimental processor board.

Since whereswally606 asked in a PM aboutsituation.
start under heavy load can be very rough and stuttering, and power application is still very "soft". soft so far is great for all day riding, but can be hindersome in cases where you need instant power like wheelies for hopping over a fallen tree or something.

I mean it would be instead of hall sensored start. And hall sensors divide the electrical rotation into only 6 pieces, so it is quite coarse. The one from the video was setup up for dividing an electrical rotation into 512 pieces, so should be much smoother. But am not there yet

Busy with some extremely interesting stuff.
DSC02111-800x800.jpg
I've started programming on a different chip, one of the 33EV types. Goal is to have sensorless start with full torque at standstill. Relative (sensorless) position


at standstill is quite easy, but to get absolute phase information requires a bit more doing. The picture above shows the different versions of analog signal processing that I am considering for processing the current sensor signals. The left one has 4 opamps, the right one 8 at the moment but should be 10... but have already scrapped that one in my mind and am drawing up schematic for version 3....
DSC02110-800x800.jpg
The new processor plugges onto the powerPCB. The analog bits plug into the bottom right header of the experimental processor board.

Interesting, what is the function of the additional analog processing between the current sense and the MCU?

Filtering and amplification... basically compensating for the ADC being only 10 bits

You could do this really easily with delta sigma based current           "done": true
        },
        {
            "title": "50x kliky",
            "datum": "11.09.2016",
            "done": true
        }
    ],
    "__v": 0
}

and i want get count of arrays where done is true. how to do it, i am total lost. I dont now how to make it happends. Help please.
Thanks lot for help

A:

Please try to do it through aggregation as below.
 Buzzer.aggregate([


isn't a perfect technique.
CCDs have pretty poor noise and distortion specs, along with all the spectral and aliasing problems of digital audio, so you won't hear much about them this side of 1980.
One such example is the SAD1024 (datasheet here) used as a pitch shifter (with continually varying pitch, aka a flanger) here

A:

I'd suggest recording the signal on a tape and playing it back at half the speed.
I cannot follow the reason why that does not satisfy you.
Of course you could use other media (e.g. wires, disks etc.); the basic principle is the same.
If none of that is good for you, you have to specify the requirements further.

A:

If the signal is periodic, then you can always use a sampling oscilloscope.

I mean, you can use any ADC provided itsaperture window and jitter is small enough, but you asked for analog, so you gonna have to use the old diode bridge sampler like the wizards of old did...
DC-14 GHz with hand soldered thru-hole parts.

Check the date, 1968 ;)


Corinth teen gets room makeover

A group of Union's Student Leaders In Community Entrepreneurship (SLICE) recently collaborated with Albany Medical Center and the nonprofit organization Healing Spaces Inc. to help a 17-year-old girl who has been battling leukemia. The students raised $3,000 to help give the teen’s bedroom a makeover through a New Jersey-based program called "Healing Spaces," which aims to bring joy to children with cancer and other serious illnesses by creating a unique healing environment in their homes.button hasn't been clicked yet.

    if(typeof this._clickFlag != 'undefined' && this._clickFlag){

       //alert if the button has been clicked once already
       alert("already accepted");

}else{

    //here I send some stuff to a database. I don't want to send it twice for the same
    //row, which is why I need to prevent a double click
    alert('_clickFlag: '+this._clickFlag + ' First time processing!');
    this._clickFlag = true;

}

});


Blog

The traditional definition of “giving” is the transfer of something without the expectation of receiving something in return. For those who actually perform this act, the word means considerably more than a simple twelve word description. I am only seven months green to the District of Columbia and these streets are far too unfamiliar to call home, but, volunteering to help those in need is something that will always make me feel more connected to my community.

As 250 children from local D.C. schools quietly entered the Caucus room in the Cannon Building of the US Capitol, their faces became so animated and eyes so wide, I couldn't stop my heart from melting. The walls were lined with Christmas decor, the tables were draped with snowflakes and Santa's helperscouldn’t covert. The game ended 3-0 after the Railhawks scored another goal during stoppage time. The U-18s will play again on Dec. 12 at 9 a.m. against the New England Revolution.

The D.C. United U-16 team had a day off after their hectic travel day. They trained and did a quick workout before the U-18s played, and then watched the game. They will play on Dec. 12 against the Indiana Fire at 2:30 p.m.

D.C. United U-16 player Jose Carranza is training with the U-15 Boys National Team during the Winter Showcase and will play his first game of the weekend on Dec. 12 at 1:30 p.m. against Weston FC. Trey Vinson will be playing in the Developmental Academy Select Squad game at 6 p.m. on the 12th as well.


align-items: baseline;
}
#comment_text {
  display: flex;
  font-weight: bold;
}
#comment_img {
  display: flex;
  background: url('https://rajohan.no/img/icons/picons_basic_1/SVG/basic1-021_chat_comment_bubble.svg');
  background-repeat: no-repeat;
  background-size: 100%;
  padding: 21px;
  margin-left: 10px;
}
#comment_count {
  display: flex;
  font-weight: bold;
}

    COMMENTS

      160

A:

I have added some code in your #comment_count.

#wrapper {
  display: flex;
  flex-wrap: nowrap;
  flex-direction: row;
  min-width: 100%;
  align-items: baseline;
}
#comment_text {
  display: flex;
  font-weight: bold;
}
#comment_img {
  display: flex;
  background: url('https://rajohan.no/img/icons/picons_basic_1/SVG/basic1-021_chat_comment_bubble.svg');
  background-repeat: no-repeat;
  background-size: 100%;
  padding: 21px;
  margin-left: 10px;
}
#comment_count {
Persistent small afferent input generated by tissue injury yields a facilitated state of nociceptive processing. The associated pain behavior is blocked by spinal delivery of agonists for Gi/o protein coupled receptors, such as 5 opiates. Analgesic efficacy occurs in part by a presynaptic inhibition of small afferent (e.g. substance P, sP). Continued intrathecal (IT) infusion of 5 opiates results in a loss of analgesic potency and a concurrent loss of suppression of sP. Enabling data suggest that with tissue injury and chronic opiate exposure the evolution of the hyperalgesic state and loss of efficacy reflects upon activation of links which involve the spinal Akt signaling cascade. These studies will undertake the following: 1. Determine expression and phosphorylation of Akt and its downstream substrates, specifically, GSK32, mTOR in spinal


still prioritize running backs and receivers over this deep position.

4. Drafting RB-RB is a losing strategy.

This refers back to the big-name receivers being generally more reliable than their running-back brethren. The top 20 running backs by ADP included 10 guys who underperformed their draft-day price, including some of the biggest busts in fantasy football: Spiller, Martin, Foster, Ray Rice, Trent Richardson, Steven Jackson, David Wilson, Stevan Ridley, Darren Sproles and Darren McFadden. Others like Chris Johnson and Maurice Jones-Drew disappointed their owners on a regular basis. For everyone who was able to get Lynch and Forte with their first two picks, 20 people ended up with a combination that included at least one bust.

We all have to survive a missed pick here and there, but it's awfully hardand thought there was a good argument for taking him ahead of Peterson. However, I didn't have a high enough pick in any of my drafts to get him. Where I was able to secure his services was in all my auction leagues. Not surprisingly, that's where I had my most success this season.

Auctions require far more skill and strategy than drafts. The chess vs. checkers strategy doesn't apply here. If drafts are checkers, auctions are international diplomacy. There really isn't an excuse for the seasoned fantasy player to still be conducting drafts. No matter who you are, you're a slave to your slot in a draft. In an auction, you can devise a strategy that you can reliably carry through to its completion. I don't know about


Drag reduction by formation movement in spiny lobsters.
Movements of spiny lobsters (Panulirus argus) in formation reduce drag during locomotion; such movement is of particular significance during mass migration. Queues (single-file lines) of spiny lobsters sustain less drag per individual than do individual lobsters moving at the same speed. It is proposed that queuing behavior conserves energy and is a consequence of the evolutionary role of migration in this particular species.docs: https://developer.github.com/v3/issues/events/#list-events-for-an-issue
func (s *IssuesService) ListIssueEvents(ctx context.Context, owner, repo string, number int, opt *ListOptions) ([]*IssueEvent, *Response, error) {
	u := fmt.Sprintf("repos/%v/%v/issues/%v/events", owner, repo, number)
	u, err := addOptions(u, opt)
	if err != nil {
		return nil, nil, err
	}

	req, err := s.client.NewRequest("GET", u, nil)
	if err != nil {
		return nil, nil, err
	}

	acceptHeaders := []string{mediaTypeLockReasonPreview, mediaTypeProjectCardDetailsPreview}
	req.Header.Set("Accept", strings.Join(acceptHeaders, ", "))

	var events []*IssueEvent
	resp, err := s.client.Do(ctx, req, &events)
	if err != nil {
		return nil, resp, err
	}

	return events, resp, nil
}

// ListRepositoryEvents lists events for the specified repository.
//
// GitHub API docs: https://developer.github.com/v3/issues/events/#list-events-for-a-repository
func (s *IssuesService) ListRepositoryEvents(ctx context.Context, owner, repo string, opt *ListOptions) ([]*IssueEvent, *Response, error) {
	u := fmt.Sprintf("repos/%v/%v/issues/events", owner, repo)
	u, err := addOptions(u, opt)
	if err != nil {
		return nil, nil, err
	}

	req, err := s.client.NewRequest("GET", u, nil)
	if err != nil {
		return nil, nil, err
	}

	var events []*IssueEvent
	resp, err := s.client.Do(ctx, req, &events)
	if err !=


prob of picking 2 b when two letters picked without replacement from ixxxbbiooxoobbssxssx?
3/95
Two letters picked without replacement from jejeejeekkeje. What is prob of picking 1 e and 1 j?
14/39
What is prob of picking 3 x and 1 s when four letters picked without replacement from {s: 1, x: 4, a: 6}?
2/165
What is prob of picking 2 v when two letters picked without replacement from {j: 5, v: 2}?
1/21
Three letters picked without replacement from {e: 4, c: 10, d: 5}. What is prob of picking 1 c, 1 e, and 1 d?
200/969
Calculate prob of picking 1 f and 1 w when two letters picked without replacement from {w: 2, i: 3, f: 2, n: 6}.
2/39
Two letters picked without replacement from ohhoxshhhhs. What is prob of picking 2 s?
1/55
Two lettersAvacyn sought to trap the ancient Demon Griselbrand, he dragged her in with him, allowing evil to flourish unchecked on Innistrad. Only through the Helvault's destruction could Avacyn be freed to balance and protect the plane once again—at least until the events of Shadows over Innistrad.

Memnarch

Created by Karn as the sentient incarnation of the maddeningly powerful Mirari artifact, Memnarch was an artificial being of immense curiosity. Karn left him to watch over the metallic plane of Argentum, but he came into contact with Phyrexian oil and gradually became corrupted by its influence. He renamed the plane Mirrodin, began filling it with kidnapped life forms from other planes, and performed terrible experiments on them in his obsessive quest for a Planeswalker's spark.

Mind's Desire

The Mirari was a dangerous artifact, and


its power was seductive. Not only did it offer a tremendous amount of magical energy, it had the ability to see and manifest its user's deepest dreams and desires. However, it also had an unfortunate tendency to bring its users to eventual ruin, and its presence on Dominaria led to magical chaos. Adam Paquette's vivid new art, like the Scourge original, offers a glimpse of the Mirari's swirling, wish-granting power.

Momir Vig, Simic Visionary

No one else embodies the Simic Combine's focus on the evolution of life itself quite like Momir Vig. Under his influence, the guild shifted from fighting to preserve the essence of Ravnican life forms to working to improve them, regardless of whether the subjects particularly wanted to be improved. Victor Adame Minguez's new art zooms inaccount to the crimes and atrocities done by you and your forces on the innocent people of Syria:
1.) Do you think it is right to suppress the people who are demanding their rights to live freely in their country?
2.) How can you justify the genocide committed by you and your regime in which your killing drive has claimed 3500 innocent lives and still counting?
3.) Will you justify your measures of handling the Syrian Revolution?
4.) Is this true that your government and your policies discriminate among the distinct citizens of your country?
5.) How would you prove that your forces and your ministers did not commit any human rights violations?
6.) Is this justified in any manner to deny the rights and freedom of the people?
7.) Do you think being a


KYIV, Ukraine — For soccer fans fed up with the corruption scandal swirling around FIFA, wishing for a governing body that loves the game more than the dollars it brings in, it turns out there may be an alternative: the Confederation of Independent Football Associations, also known as CONIFA.

True, its members might be slightly off the grid — at least in terms of international diplomacy.

That’s because they represent teams from unrecognized states, minority communities and other lesser-known regions left out of FIFA and the larger soccer world.

Take, for instance, the self-proclaimed Nagorno-Karabakh Republic, an ethnic Armenian region that broke away from Azerbaijan in the early 1990s and remains unrecognized by the international community.

Or the Arameans, an ancient Semitic people rooted in lands that now comprise modern-day Syria.

There’s evenEvery American (potentially) has skin in the game, and it will also guard against abusing our All-Volunteer Force and the National Guard to the extent that we have since Sept 11, 2001.

“But unfortunately a lot of people still buy all the propaganda that the best way to serve this country is to join the military.”

Some of them join up because there’s nothing else: no jobs, no hope of attending college, no way out of poverty than joining the military. There, they can at least learn some basic skills, including how to work as part of a team.

Politicians whose policies deliberately impoverish large swaths of the population, that like people to be kept ignorant and angry, also tend to be politicians who pursue deliberate bellicosity overseas.

It’s American Capitalism in


the forever-wars. Also, in a pinch, there are wars of choice, i.e. aggression.
There’s also a domestic Crime Shortage; or in other words, a police surplus.

@paradoctor
That is really well put…and exactly right to me. My new favorite term, and the best one to explain Larison’s “perpetual war” is “War Shortage”. And fascinating how the same concept can play into “crime shortage”.

This is facilitated by the ending of the draft. When able bodied young men from every family were required to fulfill an obligation to serve in the military, almost every family was directly effected by a war. The few exceptions were the families that were able to avoid the draft by various methods. Now most families don’t even know someone serving in the military. The result is that theyAs they cool, they begin to wilt and flatten. As they start to change shape, they are ready to be rolled. Light Rolling: It’s the rolling process that helps the tea leaves develop their unique appearance and flavor profile. As the wilted leaves are lightly rolled, they are further bruised. Bruising breaks the cell walls of the leaves, releasing the enzymes and essential oils that will alter the flavor of the leaves. Rolling further exposes the chemical components of the tea leaves to oxygen and spurs on the oxidation process. Rolling also helps define the shape the tea leaves will take.

Oxidizing: Oxidation is a chemical reaction that alters the flavor of the tea leaves and helps the processed tea develop its ultimate appearance and color. How long the


artisan tea to be picked up by worldwide distributors. But for many oolong producers, competition is a way to demonstrate their honor and passion for the life they’ve dedicated to the art of oolong tea.

Caffeine content in oolong tea

There are many factors that can determine caffeine levels of any beverage brewed from a caffeinated plant, including the variety of the plant, how the plant was processed and how the beverage was brewed. The caffeine content in an oolong tea generally falls somewhere between a black tea and a green tea. A lightly oxidized oolong may have lower caffeine levels (similar to a green tea) and a highly oxidized oolong may have higher caffeine levels (similar to a black tea). But this can vary depending on how the teaFeatures

TS-PC Racer is a powerhouse of technologies created to enhance gaming performance and offer a racing experience closer to reality, enabling gamers to be fully immersed. Thrustmaster TS-PC Servo base, Detachable Open Wheel with metal plastron and suede leather. ECOSYSTEM-READY.

External TURBO power supply to deliver constant power and massive peak power to instantly respond to ultra-fast requests from the game rendered. Toroïdal-shaped to optimize efficiency versus heat at 86%, with a finless design. Peak power: 400 Watts!

Maintains dynamics with the new motor by ensuring that there is no overheating, while remaining silent. Provides 50% more dynamics, 4 times greater stall force than TX – T300 RS’s torque, and heat dissipation via monophasic cooling.

External TURBO power supply to deliver constant power and massive peak power to instantly respond to


handled by the familiar Poisson and negative binomial models, respectively.

More specifically, the mean-parametrized CMP distribution with mean $\mu > 0$ and dispersion $\nu \ge 0$ is characterized by the probability mass function $$P(Y=y \vert \mu,\nu) = \frac{\lambda(\mu, \nu)^y}{(y!)^\nu} \frac{1}{Z(\lambda(\mu, \nu), \nu)} \ , \quad y = 0,1,2,\ldots \ ,
\label{eq:cmpExp}$$ where the rate $\lambda(\mu, \nu)$ is a function of $\mu$ and $\nu$ given by the solution to $$0 = \sum_{y=0}^{\infty} (y-\mu)\frac{\lambda^{y}}{(y!)^{\nu}} \ ,$$ and $Z(\lambda, \nu) = \sum_{y=0}^\infty \lambda^y/(y!)^\nu $ is a normalizing function. It is easy to show that $\nu < 1$ implies overdispersion and $\nu > 1$ implies underdispersion relative to a Poisson distribution of the same mean. When $\nu =1$, the distribution coincides with the Poisson distribution. We write CMP$_\mu(\mu, \nu)$ for the mean-parametrized CMP distributionof model parameters, covering both over and under dispersion. This makes them particularly suitable for Bayesian modelling and inferences.

From a Bayesian point of view, [@KSMBB2006] explored the use of conjugate priors for the standard CMP distribution in the independent and identically distributed case. While this can be easily extended to mean-parametrized CMP distributions (see Online Supplement), there are three practical limitations of using the conjugate prior. First, the subsequent posterior is known only up to a normalizing constant that has no closed-form, so computing it requires either numerical integration, Markov Chain Monte Carlo (MCMC) sampling, or some other approximation method. There is therefore no practical advantage of using the conjugate prior over any other prior. Second, appropriate specification of the hyperparameters can be rather opaque due to the


model parameters $\btheta$. This approach allows us to cancel out all intractable normalising constants. Detailed explanation of the algorithm and its comparison with the standard Metropolis-Hastings algorithm is presented in Section 3.2 of [@CENN2017]. [@Benson2017] also develop a new, faster CMP rejection sampler by building two tractable enveloping bounds. They then link the sampler with the reciprocal normalising constant, which allows the intractable likelihood function to be estimated without bias. While these approaches work nicely for regression models that are based on the standard CMP of [@SMKBB2005] and the reparameterized CMP by [@GG2008], they have not (yet) been adapted for the mean-parametrized $\cmpMu$ distribution – this has been flagged for immediate future research.

Instead, we present a direct Metropolis-Hastings (MH) algorithm that is particularly straightforward to implement. There isproposal given by the current value $\nu_0$. That is, we sample proposals $\nu_1 \sim \mbox{Exp}(1/\nu_0)$ with density $p(\nu_1) = \nu_0^{-1} \exp(-\nu_1/\nu_0)$. The corresponding acceptance probability is therefore given by $$\begin{aligned}
a_\nu &=&
\frac{p(\bbeta_0,\nu_1\vert \by, \bX)}{p(\bbeta_0,\nu_0 \vert \by, \bX)} \frac{\nu_1}{\nu_0} \exp\left( \frac{\nu_1}{\nu_0} -\frac{\nu_0}{\nu_1} \right)  \ ,
\label{eq:acceptRatioMeanCmpRegNu}\end{aligned}$$ where $\bbeta_0$ is the current value of $\bbeta$. Of course, other proposal distributions can also be used. However, we find the exponential proposal distribution to be particularly simple to work with as there is no secondary “variance"-type parameter to select. Indeed, the normal–exponential pair of proposal distributions led to excellent mixing times in the all examples that we looked at.

The MH MCMC algorithm obtained via alternating these proposals is summarized in Algorithm \[alg:compRegBayes\] below. We readily admit that this is by no means the


$(0,0.05)$, confirming strong conditional overdispersion in the data. Each MCMC update took approximately 0.2 seconds on average to run.

Underdispersed takeover bids data
---------------------------------

The $\cmpMu$ GLM – is also used to analyze the takeover bids data from [@SS2013]. For this dataset we consider a model of the form, $$\begin{aligned}
\begin{array}{rcl}
\text{bids}_i \vert \bbeta,\nu & \simind & \cmpMu\left[\exp\left\{\beta_0 + \beta_1\text{leglrest}_i + \beta_2\text{rearest}_i  + \beta_3\text{finrest}_i  \right.\right. \\
& & \left.\left. + \beta_4\text{whtknght}_i + \beta_5\text{bidprem}_i + \beta_6\text{insthold}_i + \beta_7\text{size}_i  \right.\right. \\
& & \left.\left. + \beta_8\text{size}^2_i + \beta_9\text{regulatn}_i  \right\},\nu \right],
\end{array}
\label{eq:takeBidModel}\end{aligned}$$ where $\text{bids}_i$ is the number of bids received by each firm $i$, and the explanatory variables are described in the Online Supplement. For our priors we again consider $$\begin{aligned}
\begin{array}{cc}
\bbeta \sim N(\bzero,10^5 \bI), & \quad \nu \sim \text{log-Normal}(0,10^5) \ ,
\end{array}
\label{eq:takeBidPrior}\end{aligned}$$ corresponding to vague [*acredible intervals, noting that nominal 95% credible intervals they did [*not*]{} contain $\nu=1$ in 98.0% of simulations. For narrower 90% credible intervals the power improved to 99.1%, and for wider 99% credible intervals the power was at 93.4% in our simulations. These results again suggest that the $\cmpMu$ framework can be equally useful for handling equi, over and under dispersion under both correctly specified and misspecified data-generating mechanisms. Moreover, additional simulations carried out by the second author under different sample sizes and different levels of dispersion yielded similar results to those presented in Table \[tab:coverageRateInt\].

[l<l<l<l<l<l<l<l<l<l<l<l<l< l<l<l< l<l<l<]{} & &\
& & & & & & &\
Model & level & & $\beta_1$ & $\beta_2$ & $\beta_3$ & $\beta_4$ & $\nu $ & & $\beta_1$ & $\beta_2$ & $\beta_3$ & $\beta_4$


native grass species including Idaho fescue (*Festuca idahoensis*), Sandberg bluegrass (*Poa secunda*), prairie Junegrass (*Koeleria macrantha*), and bluebunch wheatgrass (*Pseudoroegneria spicata*) ([@bibr16]). In addition, over 112 forb species have been documented in the Zumwalt Prairie Preserve (<http://conserveonline.org/workspaces/ZumwaltPrairieWorkspace/documents/zumwalt-prairie-plant-list-.pdf/view.html>).

![(a) Location of the Zumwalt Prairie in northeastern Oregon and location of pollinator traps in each pasture (sites denoted with "•" and shaded pastures were sampled in each season of each year, and traps denoted with "\*" and unshaded pastures were not sampled in June 2007) and (b) a blue vane trap. High quality figures are available online.](f01_01){#f01_01}

The study was conducted in sixteen 40-ha study pastures on a plateau located in the center of the TNC Zumwalt Prairie Preserve ([Figure 1a](#f01_01){ref-type="fig"}). The study pastures are part of a long-term study aimed atdiversity were calculated for each season in each year. In addition, in order to compare taxa richness among samples that varied in abundance, species richness estimates were generated by calculating the Chao1 richness estimator with log-linear 95% confidence intervals ([@bibr07]). When examining temporal patterns of the entire native bee community of the Zumwalt Prairie Preserve, the sample size was one, so no statistical analyses were conducted.

To examine temporal variability in bee abundance and adjusted richness at the trap level, one-way ANOVA were conducted with time as the factor, using each trap as a replicate. The purpose of this analysis was to determine if spatial variability at the scale of the trap (represented in the error term) was large enough to swamp out temporal changes observed at the larger


Q:

How does one immediately replay cards returned to hand?

Watching some of the pros play Hearthstone, I've noticed that they are able to immediately play a card returned to their hand, somehow issuing the instruction before the card rematerializes in their hand.
For example, the rope is burning and the pro has just calculated lethal. The pro does a flurry of activity which includes playing a Leeroy Jenkins, attacking with Leeroy Jenkins, using Shadowstep to return said Leeroy, playing Leeroy again, and attacking with the Leeroy Jenkins a second time. The rope burns out during the Shadowstep animation.
However, this is a pro, and after the rope burns out, the Leeroy Jenkins which is returning to hand, immediately comes back into play and attacks.
As an amateur, I have to wait until

  Vatter et al. 2018       United Kingdom       Factor analysis revealed five burden dimensions (factors): 1. social & psychological constraints, 2. personal strain, 3. personal life, 4. concerns about future and 5. guilt. Factors were associated with lower relationship satisfaction, mental health, resilience, stress, anxiety, depression, resentment, negative strain, and PD motor severity.   *n* = 127\


or China. The sample mainly included men with PD and caregivers who were women. Further clarification of gender issues in caregiving is warranted. The sample size for each ethnic group also did not allow for critical analysis of differences in caregiving as a result from race, ethnicity, and culture that could have affected caregiving experiences. In addition, variations in treatment options for different countries could affect caregiver burden and strain. Longitudinal changes in caregiver burden and coping strategies were not examined. Further trials are needed to better understand how caregiver strain varies according to the stage of progression of Parkinsonism as well as the effects of different interventions to improve health, well-being and quality of life in care providers and care-recipients.

Conclusion {#s5}
==========

As with international data, care providers ofI know this bitch named Ranetta, neighborhood dick sitter
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