HBL-100 was obtained from the Shanghai Cell Bank Type Culture Collection Committee (CBTCCC, Shanghai, China) and cultured in DMEM (Gibco, Gaithersburg, MD, USA) supplemented with 10% fetal bovine serum (FBS) (Gibco). Mycoplasma testing was routinely conducted by HD Biosciences. All cells were stored in liquid nitrogen and used for no more than 6 months after being thawed.

Patients with locally advanced breast cancer (\>5 cm in diameter or with clinically palpable axillary adenopathy) received preoperative chemotherapy, weekly paclitaxel (80 mg/m2) and carboplatin (AUC = 2). All human breast cancer specimens were obtained from patients who were diagnosed with breast cancer and underwent surgery at the Shanghai Cancer Center during 2003--2009 (*n* = 110). All specimens contained over 90% tumor cells and were stored in liquid nitrogen until analysis. The study was approved by the Ethics Committeepreoperative chemotherapy followed by surgery were divided into two groups according to the chemotherapy response. The means of the two groups were significantly different from each other (*t*-test, *p* = 0.0021). **b** Kaplan-Meier curves of disease free survival rates of 110 patients with breast cancer who had definitive surgical treatment of their primary tumors according to miR-200a expression. The optimal cut-off point was determined by X-tile program. PR: partial response, SD: stable disease, PD: progressive disease

Knockdown of TP53INP1 and YAP1 phenocopied effects of overexpression of miR-200a {#Sec17}
--------------------------------------------------------------------------------

To further identify the association between TP53INP1 and miR-200a in breast cancer, the expression of miR-200a and TP53INP1 were examined in various breast cancer cell lines (Fig. [6a and b](#Fig6){ref-type="fig"}). A reverse correlation was observed between miR-200a expression and TP53INP1 expression. The cells overexpressing miR-200a


had a lower level of TP53INP1 expression (*R* = −0.780, *p* = 0.0279, *n* = 12) (Fig. [6c](#Fig6){ref-type="fig"}). This data further indicated the functional link between miR-200a and TP53INP1 in breast cancer. Moreover, silencing TP53INP1 and YAP1 can partly reproduce treatment resistance of miR-200a overexpression (Fig. [6d](#Fig6){ref-type="fig"} and [e](#Fig6){ref-type="fig"}). These results implied that, enforced expression of miR-200a in breast cancer cell lines conferred chemoresistance via targeting YAP1 and TP53INP1.Fig. 6miR-200a expression is inversely correlated with TP53INP1 expression in breast cancer tissue. **a** Western blot analysis of TP53INP1 protein expression. **b** relative expression levels of miR-200a in human breast cancer cell lines. **c** Pearson correlation of the TP53INP1 and miR-200a expression levels in breast cancer cell lines (*R* = −0.780, *P* = 0.0279, *n* = 12). Inhibition ratio of scramble RNA, siYAP1, siTP53INP1 and miR-200a mimic transfected MDA-MB-231 (**d**) and ZR-75-30recently, miR-193a, which is regulated by p63 and targets p73, was found to be a key regulator of p63/p73-dependent chemoresistance in squamous cell carcinoma \[[@CR2]\]. In this study we showed that miR-200a expression is significantly associated with the response to chemotherapy in patients with breast cancer. Furthermore, we found miR-200a was overexpressed in gemcitabine resistant breast cancer cells, and inhibition of miR-200a can restore sensitivity to these cells. Unfortunately, we cannot determine the dynamic expression of miR-200a after treating with chemotherapy due to small chemotherapy samples and a relatively limited number of patients. Despite its preliminary character, this study clearly indicates that miR-200a acts as a negative regulator of chemotherapy induced apoptosis therefore confer chemoresistance.

The susceptibility of tumor cells to chemotherapy induced death is a major determinant in


the outcome of therapy. p73 plays a central role in chemotherapy resistance; the regulatory mechanisms that control the p73 chemotherapy response are closely related to posttranslational modifications and protein-protein interactions \[[@CR16]\]. In the current study, mRNA expression of p73 is not significantly changed with variation of miR-200a expression, indicating that regulation of p73 is not at RNA level but posttranslational level. In present study, the results showed that miR-200a can negatively regulate TP53INP1 expression through binding to its 3' UTR of mRNA. TP53INP1, which is referred to as a stress-induced protein, can be transcriptionally activated by p53 or p73 and promote p53 phosphorylation at Ser-46 as well as apoptosis in response to DNA damage \[[@CR17], [@CR18]\]. We used MDA-MB-231 (TP53 mutant) and ZR-75-30 (TP53 wild-type) in the currentstudy and miR-200a plays a role in mediating chemoresistance in both cell lines. We believe p53 does not matter in miR-200a mediated chemoresistance. TP53INP1 is a downstream effector of p73 in p53-mutant cell lines \[[@CR19]\]. Our previous study has also shown that miR-200a functions as a repressor of YAP1, which stabilized p73 under conditions like DNA damage and stress \[[@CR20]--[@CR24]\]. Therefore, in response to chemotherapy, miR-200a may lead to p73 degradation, causing attenuated transcription of downstream proapoptotic genes, such as Bax, Bim and Puma. miR-200a may also prevent apoptosis by targeting TP53INP1 \[[@CR25]\]. Thus, by targeting two nodes of the chemo-induced apoptosis pathway, miR-200a confers resistance to chemotherapy (Fig. [7](#Fig7){ref-type="fig"}).Fig. 7Schematic representation of the effects of miR-200a on chemoresistacne

Conclusions {#Sec19}
===========

In summary, we established a role of miR-200a in chemotherapy


resistance. We showed that miR-200a promotes DNA damage resistance by inhibiting DNA damage-induced apoptosis via YAP1 and TP53INP1 in breast cancer. Deciphering the association of miR-200a and chemoresistance might provide important insights into tumor progression and treatment.

Additional files
================

 {#Sec20}

Additional file 1: Table S1.List of primer and siRNA sequences. **Table S2**: Intersection between predict target of miR-200a and p53 family binding partner. (DOCX 17 kb) Additional file 2: Fig. S1.Expression of p73 in MDA-MB-231 and MDA-MB-231 GR cells. (EPS 588 kb)

DFS

:   Disease-free survival

EMT

:   Epithelial-mesenchymal transition

GR

:   Gemcitabine-resistant

qRT-PCR

:   quantitative real-time PCR

**Electronic supplementary material**

The online version of this article (10.1186/s12885-017-3930-0) contains supplementary material, which is available to authorized users.

We thank all the subjects of this study for their participation. We greatly appreciate Jin Shenindustry with us adding new products every month.

Internationally, Marvel sells its PVC Sheets to distributors and Industries directly. We design custom spec products to meet a variety of needs such as Fire Retardency, Water Proofing and for Anti-Bacterial applications.


It has a button with the label Take Picture, so you could call standard
app.WaitForElement(c=>c.Marked("Take Picture"));

to wait for that button to appear. If it appears then photo capture screen is open. You can, of course, wait for any other element on that screen.
You can even do
app.Tap(c=>c.Marked("Take Picture"));

to tap that button and actually take a picture.

whistle-blower law to claim a multibillion-dollar reward from the American government. If they succeed — and legal experts say the odds are pretty good — it would be the largest reward of its kind.

Mr. Birkenfeld, who is to begin his prison term as soon as January, is being represented by the executive director of the National Whistleblowers Center, Stephen M. Kohn. Mr. Kohn successfully represented Linda Tripp, who helped expose the Monica Lewinsky scandal of the Clinton years.

“We are seeking at least several billion dollars,” Mr. Kohn said.

It might seem outlandish that Mr. Birkenfeld, who pleaded guilty in June 2008 to conspiring to defraud the United States government, would seek any reward at all. But experts in whistle-blower cases — who, admittedly, have an interest in fostering such


claims — say he has a persuasive case.

“I do think he has a serious claim,” said Erika A. Kelton, a partner at Phillips & Cohen, a law firm that specializes in large whistle-blower claims. “It was very credible, very useful information from inside UBS that he provided. The law is pretty clean on this.”

Mr. Kohn stands to reap a fortune if Mr. Birkenfeld wins his case.

The United States Treasury loses an estimated $100 billion a year to offshore tax cheats, but finding tax dodgers is difficult. The best information, the authorities acknowledge, often comes from insiders. In recent years, the Internal Revenue Service has quietly embraced whistle-blowers like Mr. Birkenfeld to help root out tax cheats.

Federal whistle-blower laws date back to the Civil War, when the government soughtstayed there for so long.”

(Image: SplashNews.com)

The page gave chilling detail of how the money would be used. It read: “We want to raise £10,000 to hire a contract killer to kill Gina Miller. The Traitor of Democracy.”

Responding to the threat, brave Mrs Miller urged politicians to think carefully about how their language incites hate.

She said: “There is of course no excuse for any individual to resort to inciting murder, but it shows how bad things have got.

"Certain extremist politicians and commentators must take their share of responsibility and recognise that incendiary language – and continually ratcheting up the stakes – has consequences.”

The gofundme page is the latest in a string of threats against Mrs Miller.

(Image: PA)

Racist viscount Rhodri Philipps offered £5,000 on Facebook to “the first person to


The Soul Selects Her Own Society

The Soul Selects Her Own Society: Invasion and Repulsion: A Chronological Reinterpretation of Two of Emily Dickinson's Poems: A Wellsian Perspective is a 1996 science fiction short story by Connie Willis. It was first published in Asimov's Science Fiction in April 1996, but written for the anthology War of the Worlds: Global Dispatches, in which it was published in June 1996; it was subsequently republished in War of the Worlds: Fresh Perspectives on the H. G. Wells Classic (2005), in This is My Funniest: Leading Science Fiction Writers Present Their Funniest Stories Ever (2006), in The Winds of Marble Arch and Other Stories (2007), and in The Best of Connie Willis: Award-Winning Stories (2013).

Synopsis

Rather than being a conventional narrative, "Selects" is presented asdiffer in the
    lengths of their UTRs.

    751 transcripts overlap with those in the previous set, but do not show consistent splicing
    (i.e., they contain overlapping introns with differing splice sites)


your post. You can turn off comments for individual posts from the Discussion tab under the Document tab.

You’ll also see the option to allow pingbacks and trackbacks. These allow you and other blogs to notify each other when they link to an article.

7. Pending review option will add a custom status next to your post as ‘Pending review’. This feature is particularly helpful on multi-author blogs where contributors can just save posts and not publish them.

8. If you want to delete a post, then you can click on ‘Move to trash’ button. WordPress will send the post to trash. Deleted posts will remain in the trash folder for upto 30 days. After that, they will be deleted permanently.

Edit Screen Options

WordPress allows you to show and hide panels fromthe edit screen. You can do so by clicking on the three-dot menu at the top-right corner of the screen and then clicking on the ‘Options’ button.

This will bring up a popup where you can check or uncheck the panels.

Other Post Edit Screen Options

There are many other options on the post edit screen. Most of them are related to the appearance of the post edit screen and the editor itself.

Let’s explore them.

When you click on the three-dot menu icon at the top right corner of the screen, you will see options to move block toolbar to the top, spotlight mode, fullscreen mode, switch between visual editor or code editor, manage reusable blocks, and keyboard shortcuts.

Next to it, you will see a button with the gear icon. Clicking on


to me like "Fix Me Teeth!" - and or my favorite - "Here's the Crown Prince - don't overcharge me!"- I've even had 'I Love YOU Andrew!'"

Peter O’Meara can next be seen in Charles J Haughey-inspired drama, Citizen Charlie.visited South Africa during the early 1930s (maybe 1934)
where the word Gratis in Afrikaans is equivalent to "for free". It is
anecdotally thought, therefore, that he brought back with him
the idea for a free film service called Gratispool. However,
it is also possible that he just coined the name Gratispool,
with the business idea having already been mutually agreed with
his partners before his trip. By whatever route, the Gratispool
idea began (maybe experimentally at first) by advertising the
supply of a free (black & white) film with each returned
set of prints. Initially an order had to be for more than 1s/10d
(9p) to qualify = price of developing & printing an 8 exposure
film. This new service operated from the postal address of 37 Isles Lane, Leeds.
The Gratispool company was formally registered (incorporated)
in London on


shown
below, though Michael Adler and his sister Sue Lipschitz
have no knowledge of their father having Johannesbury business
connections.

The
photograph shown left is the Adler family in Cape Town in 1957;
Norman, Suzanne, Anita and Michael.

Referring to his father's business
at Caledon Street, Michael Adler recalls: "There were three
floors with the post being opened each morning (sacks of post
in large post office bags) on the ground floor and developing
on the top floor, with printing on the floor between. I remember
the huge developing tanks and the smell of the chemicals. The
opening of the post was most important. It came from all over
Africa and we used to keep the stamps" (this is further
evidence of Norman's interest in philately, see above, the '3-Kings'
stamp and 1st Day Cover).

"Supplies of materials
for films came from England so that afree (paper negative) film
could be returned for every one received. I remember the large
wooden printing machines and the powerful lights. Dad sent for
Ernest Carlson from England after a few years - he had been his
factory manager in England. At one stage there was a trolley
bus with Gratispool adverts. In the mid-1950s colour photography
started with special paper and many chemicals. It seemed very
complicated and in order to keep up, Dad sent me (Michael) to
Johannesburg in 1957 to study the process at the Kodak factory.
Before that, he used to very carefully colour some of the pictures
by hand and I still have his magnifying glass on my desk."

"The S.African Government
passed the Population Registration Act in 1950 and this
required that everyone had to be photographed for an identity
document. Dad was very busy


sale, Gratispool
started to sell movie cameras and complete cine kits, to create
a market for the film. These sold amazingly well such that Gratispool
next opened a shop in Queen St, in the shopping area of Glasgow,
and considerably widened their range of equipment. The story
behind Gratispool's move into selling cine equipment can be read
in Bill Kerr's account
of working as the Scottish Regional Salesman for Mayfair Photographic
Suppliers (London) Ltd. during 1962-64.

The 32ASA Kodak Ektachrome
colour transparency film processing & mounting service had
increased slightly in cost (since 1960) to 18/9d (94p), including
another Ektachrome 20exp. 35mm film. The roll film price remained
at 15/6d = 77.5p.

Until 1963 Gratispool imported its US Dynachrome
film in 8mm cine size only and returned it to Dynacolor for processing.
However, from 1963 Gratispool also imported the film in bulk
rolls which couldthreatening
to sue, and on top threatening to write to the papers. They had
to always work from the top!

The Dynacolor Corporation was
acquired by 3M in 1963 and by 1965 Dynachrome was being imported
into the UK by 3M's British subsidiary (Minnesota Mining &
Manufacturing Co. Ltd.) who then supplied to other UK outlets
than Gratispool (Dixons ?, see para above). In 1966, 3M began
supplying Dynachrome to Gratispool, avoiding the need for Gratispool
to import it from the US. 3M also acquiring the Italian transparency
film manufacturer Ferrania in June 1964 and within a couple of
years Gratispool changed to supplying Ferrania film under the
'International' brand. Dynachrome remained available (in the
US) until 1970.

Ektachrome processing continued,
eventually as 64ASA (Kodak first introduced 35mm 64ASA Ektachrome
as Ektachrome X in late 1963, having been available in the new
126 Instamatic format


late 1977) E4 gave way to the current
E6 process, which retains chemical reversal but uses more environmentally
friendly chemistry.

Gratispool's prints from transparencies
cost 1/9d (9p) for the 3.5"x3.5" size or 2/- (10p)
for 5"x3.5". These were made using an internegative
process with subsequent printing onto conventional colour print
paper. There was a problem with the final image quality, because
of the two stage process. This service was discontinued after
two or three years, when Gratispool had established themselves
in colour negative film developing & printing. Later Kodak
introduced a reversal paper that allowed reversal printing direct
from the original slide, but quality control remained difficult.
('Ektachrome' Type 1993 in 1972 was replaced by the lower contrast
& faster Type 2203 in 1976; meanwhile -1974/75- Kodak Pathé
in France produced the even faster 'Ektachrome' 14RC paper, with
'Ektaprint' 14 chemicals, and made itto the
1964 cost of 19s/11d (near £1). The marketing had also
changed. Gratispool now claimed their colour film to be 'Free',
by virtue of supplying a 10/- (50p) refund voucher when a customers
sent 10/- for their first film (still or cine). Thus, the customer's
total outlay for a set of 35mm colour slides, including a replacement
film, was 21/-, even if they had never used the service previously.
This colourful advert
contains the details.

RHS (above) is a school photo
frame with the Gratispool name; found here.The Gratispool International
Schools Div'n was started in 1966 by Nigel Stead.
It visited schools 'from John O'Groats to Cardiff.' The story
of how the Schools Division went from photographing 4,000 children
in 1966 to 500,000 in 1974 is told in Issue 4, of 'interVIEW',
The Journal of the Gratispool Group, started in 1973-74.

In September


SupaSnapS promotional
'cool bag' bearing the logo 'Fast or Free'. This
relates to a SupaSnapS TV advertising campaign from the 1980s
which promoted the SupaSnaps jingle:

"They're
back when we say, or you don't pay, - that's the promise we keep
at Supasnaps!".Click
here to see a short
video of that advert, courtesy of Andy Ensor.
This video is in wmv format which will run in either Windows
Media Player or Real
Playerand doubtless various other players freely available on the
Internet.

The 'cool bag' measures some 300mm
long, by 200mm wide by 160mm deep.

This example has survived well
but the handles are starting to pull away from the plastic body.

Dixons sold the Gratispool
laboratories in a Management Buy-Out (MBO) but retained the SupaSnapS
stores. Subsequently Dixons sold SupaSnaps to Sketchley (part
of Johnsons Cleaners UK Ltd) who took some advantage that the
dry cleaning season tendsFilm Service" for slides were all CR-50.

The film speed was 19DIN = 64ASA
(ISO)

Keith learned
of the 'Ferrania connection' when (later) a friend gave him a
"Gratispool International" film which was (by then)
rated at 64ASA. He remembers sending this to Gratispool for processing
and subsequently became aware that the film's edge identifier
was the same as on a 3M Ferrania CR50. By 1970/71, Keith
was processing "Gratispool International" film himself
using CR50 chemistry, satisfied that (by then) Gratispool 35mm
transparency film was indeed Ferrania CR50. The film above was
probably manufactured around 1970 as it has an August 1972 expiry
date.

Although CR50 had an 'official'
speed rating of 50ASA, it was conducive to uprating by modified
processing (which might explain why Gratispool claimed it to
be 64ASA). Its possible Gratispool sold CR50 as 64ASA to obscure
its true identity or to claim


muscle protein breakdown is also stimulated with exercise, in the fed state, the net balance of the protein breakdown and synthesis is increased after exercise, which leads to muscle protein gain and thus muscle hypertrophy \[[@B67-nutrients-10-00605],[@B68-nutrients-10-00605]\]. It should be noted that the main goal is to improve mobility and autonomy of the obese sarcopenic patients, by improving elasticity, strength, and muscular endurance. Exercise prescription should take into account the intensity, volume, frequency, and progression of training. Since exercise is an effective strategy to improve the body composition parameters in both sarcopenia and obesity, exercise, as a strategy to counteract sarcopenic obesity, is extensively discussed in the literature. Below, the effect of the different types of exercise on the sarcopenic obesity parameters will be discussed, namely, resistance, eccentric, aerobic,concurrent, and electro exercise. [Table 1](#nutrients-10-00605-t001){ref-type="table"} provides an overview of the different studies that have investigated the effect of various exercise modalities in sarcopenic obese individuals.

5.1. Resistance Exercise {#sec5dot1-nutrients-10-00605}
------------------------

Resistance exercise is currently seen as the most effective exercise strategy in order to elicit muscle hypertrophy and to improve muscle function and strength in older adults \[[@B69-nutrients-10-00605],[@B70-nutrients-10-00605],[@B71-nutrients-10-00605],[@B72-nutrients-10-00605]\]. The majority of the studies have been performed among older, non sarcopenic obese adults. For example, a meta-analysis of 49 studies, with in total 1328 participants of 50 years and over, showed that, on average, the skeletal muscle mass was increased by 1.1 kg (95%CI: 0.9--1.2, *p* \<0.01) after an average of 20.5 weeks of resistance training two to three times a week \[[@B71-nutrients-10-00605]\]. Another meta-analysis of Peterson and colleagues also illustrated


strategy to improve the skeletal muscle mass and function, and simultaneously support the loss of fat mass in sarcopenic obese older adults.

A randomized controlled trial with 45 healthy adults found that concurrent training six days a week for 12 weeks, resulted in similar improvements in maximal oxygen consumption (VO~2max~), compared to aerobic exercise alone, but the improvement in the knee extension one repetition maximum (1 RM) was lower than in the resistance exercise group alone (10.0 kg vs. 8.2 kg, *p* \< 0.05) \[[@B95-nutrients-10-00605]\], and similar results were found in elderly men (*n* = 60) \[[@B96-nutrients-10-00605]\]. These results indicate that aerobic exercise potentially leads to a blunted hypertrophic response to resistance exercise in non-sarcopenic obese individuals. Villareal et al. \[[@B64-nutrients-10-00605]\], however, showed that the combination of both aerobicintake, and therefore potentially reduced the obesity risk \[[@B130-nutrients-10-00605]\]. Thus, merely focusing on the total amount of dietary protein may not be most optimal for improving the parameters of sarcopenic obesity, as a more spread protein intake during the day may also be an important factor that augment the effect of its intake.

Another strategy would be to combine several anabolic nutrients, such as protein, amino acids, vitamin D, and omega 3. Indeed, recent studies have shown that combining whey protein, which has been enriched with leucine and with vitamin D, could increase protein synthesis and finally promote muscle mass gain in older adults \[[@B131-nutrients-10-00605],[@B132-nutrients-10-00605]\]. It was reported that this combination was also effective in adults (35--65 years) \[[@B118-nutrients-10-00605]\] and in obese older adults \[[@B133-nutrients-10-00605]\].

In summary, the sufficient intake


                                                                             PPT (points): RE: 3.9, SE: 0.4, AE: 0.9, SE: 0.4, RE + AE: 5.5, SE: 0.4, all with *p* \< 0.001

  Kim et al. \[[@B91-nutrients-10-00605]\]           139      81        decline
to exercise jurisdiction over this interlocutory appeal.
    That position cannot be squared with Supreme Court and
circuit precedent. It has long been clear that an order deny-
ing qualified immunity, “to the extent that it turns on an
issue of law, is an appealable ‘final decision’ within the
meaning of 28 U.S.C. § 1291 notwithstanding the absence of
a final judgment.” Mitchell v. Forsyth, 472 U.S. 511, 530
(1985). Qualified immunity is a form of immunity from
suit—that is, the trial process and attendant burdens—not
merely immunity from damages. Id. at 526–27.
    The Supreme Court has not had occasion to decide
whether an order denying qualified immunity may be
immediately appealed when the suit also seeks injunctive
relief. Id. at 520 n.5. We have done so, however. In Scott v.
Lacy, 811 F.2d 1153


                     21

have understood that he was violating it.” Plumhoff, 572 U.S.
at 779.
    Neither Elyea nor Fields provides the required level of
specificity. Elyea amounts to a general admonition that
officials must exercise medical judgment rather than me-
chanically apply categorical rules. And Fields doesn’t place
“beyond debate” the proposition that medical professionals
violate the Eighth Amendment when they provide hormone
therapy but decide—after extensive deliberation and consul-
tation with an outside expert—to deny sex-reassignment
surgery. White, 137 S. Ct. at 551. In both cases prison officials
refused to provide any treatment for serious diseases based
solely on categorical rules. That simply didn’t occur here.
These DOC officials consulted an expert in the field and,
facing a gray     III. Conclusion
   Because clearly established law did not require
Wisconsin prison officials to provide Campbell with gender-
dysphoria treatment beyond hormone therapy, the defend-
ants are immune from damages liability. The district court’s
decision to the contrary is
                                                     REVERSED
No. 18-2075


                                  No. 18‐2075

an individual prisoner. Id. at 558–59. We concluded that “[i]t
is well established that the Constitution’s ban on cruel and
unusual punishment does not permit a state to deny eﬀective
treatment for the serious medical needs of prisoners. … Re‐
fusing to provide eﬀective treatment for a serious medical
condition serves no valid penological purpose and amounts
to torture.” Id. at 556. Our bottom line was simple: “Just as the
legislature cannot outlaw all eﬀective cancer treatments for
prison inmates, it cannot outlaw the only eﬀective treatment
for a serious condition like [gender dysphoria].” Id. at 557.
    Recently, init was clear to the defendants
that they were being deliberately indiﬀerent to Campbell’s
objectively serious medical need.
   The first half of this inquiry is easy. We recognized in 1997
that “[g]ender dysphoria … is a serious psychiatric disorder.”
Maggert, 131 F.3d at 671. It has thus been established for more
than 20 years that gender dysphoria is a serious medical need;
No. 18‐2075                                                    31

commendably, the defendants in this litigation do not con‐
tend that it is not. See also Fields, 653


was ‘lit‐
erally ignored’ to prevail on a deliberate‐indiﬀerence claim.”).
32                                                   No. 18‐2075

A plaintiﬀ may prove deliberate indiﬀerence through evi‐
dence that the defendant’s treatment was far outside of med‐
ical norms. “[I]f the defendant’s chosen ‘course of treatment’
departs radically from ‘accepted professional practice,’ a jury
may infer from the treatment decision itself that no exercise
of professional judgment actually occurred.” Id. (quoting
Pyles v. Fahim, 771 F.3d 403, 409 (7th Cir. 2014)). Similarly, it
has long “been established that the choice of an ‘easier and
lessthat testimony, Campbell could prevail.
    The majority attempts to distinguish De’lonta because it
was an appeal of a motion to dismiss under 28 U.S.C. § 1915A,
and because the plaintiﬀ there had not yet been evaluated by
a gender‐identity medical specialist. Ante at 21 n.2. But just as
in a motion‐to‐dismiss posture, in a qualified immunity inter‐
locutory appeal we must draw inferences and resolve factual
disputes in the plaintiﬀ’s favor. And the fact that the defend‐
ants in De’lonta had not yet allowed De’lonta to see a specialist
has no bearing on the legal question whether refusing to pro‐
vide universally accepted surgery would violate the Eighth
Amendment. As the Fourth Circuit recognized, a surgical
consultation was merely one step toward curing the potential
constitutional violation. See De’lonta, 708 F.3d at 526 & n.4.


2002.
On July 21, 2003, MARTA suspended all income payments to Bridges based on its claim that aggravation of his condition by work had ceased. OCGA § 34-9-1(4).
Bridges requested a hearing which was conducted by ALJ Badcock-Hagler in August 2003, on the issues of benefit reduction and suspension. In her ruling of December 10, 2003, Badcock-Hagler found that the reduction and suspension of benefits were improper and that Bridges was entitled to recommencement of temporary total disability payments. She also specifically found that
the employer/self insurer has failed to prove compliance with the mandatory requirement [(OCGA § 34-9-104(a)(2))] of filing a Form 104 [(Dr. Bernot)] with the Board. The Board's file does not contain a copy of a Form 104 [(Dr. Bernot )] and the employer/self insurer was not ableare semantically equivalent. In this paper, we consider how we can diversify the suggestions such as with [{`Sure`; `Sorry I can’t`; `What time?`}]{} without losing any relevance. Our hypothesis is that encompassing greater semantic variability and intrinsic diversity will lead to higher click-rates for suggestions. Smart-reply has been modeled as an sequence-to-sequence (S2S) process [@Li2016ADO; @Kannan2016; @VinyalsL15] inspired by their success in machine translation. It has also been modeled as an Information Retrieval (IR) task [@HendersonASSLGK17]. Here, replies are selected from a fixed list of responses, using two parallel *Matching* networks to encode messages and replies in a common representation. Our production system uses such a Matching architecture. There are several practical factors in favor of the *Matching-IR* approach. Production systems typically maintain a curated response-set (to have


training.

Note the denominator in the *symmetric-loss* is different from a softmax (where the marginalization is usually over the $y$ terms) to approximate $p(y_{i}|x_{i})$. Instead, it the sums over each message w.r.t. all responses and vice-versa. This normalization (analogous to a Jaccard index) in both directions enforces stronger constraints for a dialog pair[^2]. Thus, it is more appropriate for a conversational model where the goal is *conversation compatibility* rather than *content similarity*. Symmetric loss improved the relevance in our model. We omit the results here, to focus on diversity.

[ $$\begin{gathered}
            p(\Theta_{x_i y_i})=\frac{
                e^{\Theta_{x_i y_i}}}
         $\Phi_Y(y_i)$ is generated conditioned on $\Phi_X(x_i)$ and $z$. The purpose of learning the LVM is to maximize the probability of observations $\Phi_X,\Phi_Y$ by marginalizing over $z$. This is typically infeasible in a high dimensional space.

Instead, the variational framework seeks to learn a posterior $Q_{\phi}(z|\Phi_{X},\Phi_{Y})$ and a generating $p_{\varphi}\left(\Phi_{Y}|\Phi_{X},z\right)$ function to directly approximate the marginals. In the neural variational framework  [@Kingma2013AutoEncodingVB] and the conditional variant CVAE [@Sohn_CVAE], the functionals $Q_{\phi}$ and $p_{\varphi}$ are approximated using non-linear neural layers[^4], and trained using Stochastic Gradient Variational Bayes (SGVB).

We use two feed forward layers for $Q_{\phi}$ and $p_{\varphi}$ as shown in equations \[eq:CVAE\_Encoder\] and \[eq:CVAE\_Decoder\]. Here, $\overleftrightarrow{}$ denotes the concatenation of two vectors. To sample from $Q_{\phi}$, we use the re-parameterization trick of Kingma . First, we encode the input vectors interpreted as


mean and variance $\left[\mu,\sigma^{2}\right]$. Next, we transform to a multivariate Gaussian form by sampling $\varepsilon\sim\mathcal{N}(0,I)$, and apply the linear transformation in equation \[eq:Reparameterization\]. We reconstruct the response vector as $\hat{\Phi}_Y$ with $p_{\varphi}$ (equation \[eq:CVAE\_Decoder\]). Figure \[fig:Matching-CVAE-Architecture\] shows the complete M-CVAE architecture.

The network is trained with the evidence lower bound objective (ELBO) by conditioning the standard VAE loss with response $\Phi_Y$ in equation \[eq:ELBO\]. The first term can be computed in closed form as it is the KL Divergence between two Normal distributions. The second term denotes the reconstruction loss for the response vector. We compute the reconstruction error using the symmetric loss, $p(\hat{\Phi}_Y(y_{i}),\Phi_{Y}(y_{i}))$ from equation \[eq:symmetric\_loss\] in the training minibatch. As is standard in SGVB, we use only one sample per item during training.

[ $$\begin{gathered}
   /**
 * Copyright (c) 2013-2020 Nikita Koksharov
 *
 * Licensed under the Apache License, Version 2.0 (the "License");
 * you may not use this file except in compliance with the License.
 * You may obtain a copy of the License at
 *
 *    http://www.apache.org/licenses/LICENSE-2.0
 *
 * Unless required by applicable law or agreed to in writing, software
 * distributed under the License is distributed on an "AS IS" BASIS,
 * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 * See the License for the specific language governing permissions and
 * limitations under the License.
 */
package org.redisson.api;

import java.util.concurrent.TimeUnit;

import org.redisson.client.codec.Codec;

/**
 * Base interface for all Redisson objects
 *
 * @author Nikita Koksharov
 *
 */
public interface RObject extends RObjectAsync {

    /**


*/
    void restore(byte[] state);

    /**
     * Restores object using its state returned by {@link #dump()} method and set time to live for it.
     *
     * @param state - state of object
     * @param timeToLive - time to live of the object
     * @param timeUnit - time unit
     */
    void restore(byte[] state, long timeToLive, TimeUnit timeUnit);

    /**
     * Restores and replaces object if it already exists.
     *
     * @param    */
    byte[] dump();

    /**
     * Update the last access time of an object.
     *
     * @return true if object was touched else false
     */
    boolean touch();

    /**
     * Copy object from source Redis instance to destination Redis instance
     *
     * @param host - destination host
     * @param port - destination port
     * @param database - destination database
     * @param timeout - maximum


the air-flow control valve is operated to close the air inlet passageway at an increased frequency and/or prolonged durations so as to reduce the flow rate of air through the air inlet passageway and enrich the air-fuel mixture to be produced in the carburetor until the fuel-to-air ratio of the mixture as monitored from the exhaust gases resulting from the mixture is found to have reached the target value. If, conversely, the fuel-to-air ratio of the combustible mixture produced in the carburetor is found to be higher than the predetermined target value, viz., the mixture is found to be richer than a mixture having the desired fuel-to-air ratio, then the air-flow control valve is operated to open up the air inlet passageway at a reduced frequency and/or forTime Division Multiplexing (TDM) mechanism to carry the data signal over the higher bandwidth pipe constituted by the sub-signal.
This approach presents two distinct drawbacks. First, the necessity to use a multiplexing mechanism makes the optical transmission system complex. Second, when the sub-signal is subdivided, the various parts that result from the division are all usable independently with the exception that such use is restricted over the entire length of the sub-signal path. For example, a second data signal can be multiplexed with the first data signal and both signals transported over the sub-signal at the condition that the first and second data signals follow exactly the same path through the optical transmission system. In practice, this is not always the case since the second data signal may follow


to the bandwidth of the- data signals to be transported. As a consequence, the necessity to implement a multiplexing mechanism over one or more sub-signals is reduced, perhaps even eliminated.
Under a specific and non-limiting example of implementation, the invention provides an optical transmission system that comprises a transmitter element, an optical transmission medium such as an optical fiber and a receiver element. In addition to using sub-signals of non-uniform bandwidth, the sub-signals are also spaced in the optical frequency domain in a non-uniform manner. Under this example of implementation, the sub-signal spacing is related to the bandwidth of the sub-signals. For instance, sub-signals of relatively low bandwidth are spaced closer than signals of relatively high bandwidth. One advantage of this exemplary embodiment is the ability to increase thebased on their actions.

Adblock Plus, owned by Eyeo, started making millions of dollars by charging major companies such as Google, Microsoft and Amazon huge fees to get their ads white-listed, which allows some Acceptable Ads to appear to Adblock Plus users.

The same has happened in a similar way to AdBlock from Michael Gundlach.

AdBlock was sold to an anonymous buyer in 2015 and on October 15, 2015 Gundlach’s name was taken down from the site.

In the terms of the deal, the original developer Michael Gundlach left operations to Adblock’s continuing director, Gabriel Cubbage, and as of October 2, 2015, AdBlock began participating in the Acceptable Ads program like AdBlock Plus.

Henrik Sorensen thinks that Adblock Plus and other ad blockers currently employing “Acceptable Ads” have “a fine line to walk.”

“


to their users, Google and other companies like Apple are launching their personal Ad Blockers to prevent the growing popularity of bad Ad Blockers that are changing the web pages as they wish.

Finally the huge use of Ad Blockers on small-medium sites is increasing the likeliness of the death of those companies that won’t be able to sustain themself just by showing ads on their websites.

The same is happening on big sites like Youtube where Youtubers are losing hundreds or thousands of dollars each month because of AdBlockers.

The need for a Change

I felt too much guilt after more than 15 years of Ad Wars.

I started thinking about how much I took from Youtubers without giving them back anything, the same for many other websites running purely on Ads.group has flushed out its Rolodex of Acceptable Psychedelic Influences. On "True Believers", frontman Alex Mass bends his voice into a spooky and near-perfect approximation of Jefferson Airplane singer Grace Slick. "Haunting at 1300 McKinley" borrows some bluesy shuffle from the Animals. "Yellow Elevator #2" slips from a spiky Pink Floyd-inspired organ hook to an eerie Odessey and Oracle-worthy outro. These are welcome additions to the band's sonic palate, but the past doesn't hold all the answers for the Black Angels. Their eerie vibe doesn't mesh very well with the hippie decade's perkier moments. "Sunday Afternoon" brings those 13th Floor Elevators riffs back up to speed, but lacks that band's cult-ish quirks. "Telephone", the album's up-tempo tambourine-fueled first single, comes off as an underdeveloped British Invasion pastiche. Or


maybe it's just out of place, sandwiched between haunted-head-shop fare like "The Sniper".

Instead, the record works best when the band simply reigns in the sludgy brew th [#script:http://pitchfork.com/media/backend/js/tiny_mce/themes/advanced/langs/en.js]|||||| at defined its sound early on. Whether pushed by Sardy or entirely of their own volition, the Black Angels have tightened up their songwriting. It's the subtle things that make a difference-- laying off the atmospherics, incorporating sudden shifts, and clamping down on the meandering jams. Album opener "Bad Vibrations" starts pretty much where Directions to See a Ghost left off, but it gets an adrenaline shot for a noise-addled final minute. The album's heaviest track, "River of Blood", cycles from steady groove to free-form freak-out to precision-wound fuzz riffage in just four minutes.

The Black Angels had some great songswith technology? Check out Revision3. Like classic movies? Visit Movie Vault.

3. Support for Private TV channels

You expect the "regular" TV channels on one of these devices. You might be satisfied with the specialized channels. But Roku has another benefit: Besides the public networks, Roku lets people put up their own "private" channels, TV streams that aren't vetted by Roku. Adventuresome TV watchers can find just about anything on these channels. Some, like Nowhere TV, perhaps the best of the private channels, bring together a wide variety of free Internet videos, while others are for adults only.

2. Ease of use

Back in the bad-old days, which weren't that long ago, hooking your TV to the Internet was a nightmare.

Here's how you setup a Roku box today: You plug it in,


"Where the heck is that show!?" I can't understate just how valuable this feature is.

Put it all together and what do you get? With Roku, you get the best darn single Internet TV device available today. If you're going to have just one Internet TV media streamer, make it a Roku. You'll be glad you did.

Related Stories:Increases in JAM-A, Cx43, and VE-cadherin expression might mediate monocyte transmigration in ox-LDL-stimulated endothelial cells, which occurs independently of their intracellular and between-cell junction functions. To further investigate the role of JAM-1, Cx43, and VE-cadherin in monocyte transmigration, we used siRNA to knock down JAM-A, Cx43, and VE-cadherin protein expression. The results indicated that the downregulation of JAM-A, Cx43, and VE-cadherin expression led to a decrease in ox-LDL-induced monocyte transmigration. These results also imply that JAM-A, Cx43, and VE-cadherin mediate monocyte transmigration. Moreover, we found that the ginkgolide B-induced inhibition of JAM-A, Cx43, and VE-cadherin expression is linked to the suppression of Akt phosphorylation. Akt might be an important pharmacological target of ginkgolide B in the regulation of junction protein expression and amelioration of vascular permeability.

In conclusion, ginkgolide


B decreased the expression of JAM-A, Cx43, and VE-cadherin and reduced monocyte transmigration in ox-LDL-treated HUVECs. These effects might be associated with improvements in vascular permeability. The mechanism of action appears to be linked to the attenuation of Akt phosphorylation in ox-LDL-stimulated HUVECs.

This work was supported by grants from the National Natural Science Foundation of China (Grant nos. 81270379, 81070231, and 81471051).

Conflict of Interests
=====================

There is no conflict of interests regarding the publication of this paper.

Authors\' Contribution
======================

Xueqing Liu and Wenjia Sun contributed equally to this work.

![Ginkgolide B inhibits JAM-A expression in ox-LDL-treated HUVECs. (a) Immunofluorescent detection of JAM-A expression. (b) Western blot analysis of JAM-1 expression. (c) Density analysis of JAM-A expression. The data were obtained from four independent experiments. ^\#^ *p* \< 0.05, ox-LDL-treated cells*versus* non-ox-LDL-treated cells; ^*∗*^Ginkgolide B reduced monocyte transmigration in ox-LDL-treated endothelial cells. (b) HUVECs were treated with si JAM-A for 48 h. Monocyte transmigration was detected in ox-LDL-treated and si JAM-A-transfected cells. (c) Monocyte transmigration was detected in ox-LDL-treated and si Cx43-transfected cells. (d) Monocyte transmigration was detected in ox-LDL-treated and si VE-cadherin-transfected cells. The data were obtained from three independent experiments. ^\#^ *p* \< 0.05, ox-LDL-treated cells*versus* non-ox-LDL-treated cells; ^*∗*^ *p* \< 0.05 and ^*∗∗*^ *p* \< 0.001, ox-LDL-treated cells*versus* ginkgolide B-treated cells.](OMCL2015-907926.004){#fig4}

![Ginkgolide B and LY294002 inhibit Akt phosphorylation and LY294002 suppresses JAM-A, Cx43, and VE-cadherin expression in ox-LDL-treated HUVECs. (a) The upper panel showed that ginkgolide B inhibits Akt phosphorylation. The lower panel is density analysis of Akt phosphorylation. (b) The upper panel showed that LY294002 inhibits Akt phosphorylation. The


Q:

Script for separating series of photos

I need to visually separate photos (JPEGs) in a folder by placing black placeholder pictures between series with identical file names (only last two digits of the file names are different). The folder is typically containing single (stand alone) photos, named something like 03-12345-randomfilename.jpg and series named 03-12345-file01.jpg, 03-12345-file02.jpg, ..03, ..04, etc.
The singles should be left alone, but I need to place a black picture before and after all series.
I have the following Python script (originally written by someone else) that is intermittently failing for no apparent reason. It usually works, but sometimes it will overwrite files in the middle of a series, or more typically, it will fail to place a black picture after the last photo in a series. I've spentlot said about the specs of LG Nexus 4, again – and we just can’t help running through it again and again, so here’s what it is that we mostly already know. The LG Nexus 4 packs in Snap Dragon 1.5 GHz quad-core S4 processor, 2 GB RAM, 4.7-inch screen (768 x 1280 pixels) and an 8 megapixel camera, contrary to 13 MP camera often rumored.

Now, a bummer. This prototype was seen running Android 4.1.2, not the Android 4.2 version of Android OS, also know as Key Lime Pie, so that’s a little bit worrying for android super-enthusiasts. But since it’s only a test unit, there is really non need to panic over this, because the final version should still have Key Lime Pie pre-installed, given how convincing


from a branch) and the one underneath it (zig-zag edges), you skipped the constructional steps (shown here: https://drawabox.com/lesson/3/2/skipping) - don't skip that and I think you should be good to go!

Branches - just like your leaves, your branches are flowing really nicely! You maintained the thickness of the branch (I personally had some trouble with that when I was doing this exercise) and I don't see a lot of visible tails, which is great. In some branches, you're also changing the degree of the ellipses, which is awesome and helps portray 3D-ness. I notice though that you are not drawing through your ellipses, make sure to draw through them atleast twice and applying the ghosting method before you do so to get confident ellipses.

Plant drawings - I reallyand 24-locus MIRU using standardized methods \[[@pone.0153575.ref015]\]. The genotyping data is linked to the National Tuberculosis Information Management System (TIMS) using a unique patient identifier so that initial drug susceptibility profile, clinical, socio-demographic and risk factor data are available for each genotyped isolate \[[@pone.0153575.ref015]\]. From January 1, 2009 to December 31, 2013, spoligotype patterns in octal designation, 24-loci MIRU-VNTR, patient residential zip code and age at time of diagnosis, pre-treatment drug resistance profile, HIV status, history of incarceration, and country of birth were available for 2,531 culture confirmed TB cases.

Strain Classification and Spatial Mapping {#sec008}
-----------------------------------------

The 2,531 isolates were classified into 74 strain families and sublineages using the web application ***MIRU-VNTR****plus* on the spoligotype and 24-locus MIRU-VNTR data \[[@pone.0153575.ref026]\]. Loci were ordered as reported in Mazars et al., 2001


studies comparing the secondary infection rates of these genotypes and their capacity to cause lung cavitation as proxy measures for virulence are warranted.

Comparing the clinical characteristics of the multinomial Haarlem clusters identified in this study, we observed that resistance to first-line anti-tuberculosis drugs was significantly higher in the Southern clusters predominated by Foreign-born persons compared to the Northern cluster, while HIV prevalence was similar in both clusters. Our findings are not surprising as initial drug resistance to first-line anti-tuberculosis drugs is expected to be higher in individuals born in countries where TB treatment is at first empirical and infrastructure for drug susceptibility testing is lacking \[[@pone.0153575.ref046]\]. HIV and anti-tuberculosis drug resistance have been cited as two contemporary drivers of MTBC genetic diversity, as they may act together toseveral species of sooty mould may coexist on the same host. For example, sooty mould fungi from seven genera are found in association with *Nothofagus* (beech) in New Zealand [@pone.0070316-McKenzie1]. They are believed to derive their nutrients from coelostomidiid honeydew, which is a complex mixture of water-soluble carbohydrates such as sugars, sugar alcohols, water, free amino acids and proteins that varies among species [@pone.0070316-Dhami1]. This is believed to be due to differences in physiology of the scale insect species, rather than the influence of host tree or geographic location, as determined by previous work on honeydew compositional differences amongst these scale insect species [@pone.0070316-Dhami1]. Similar differences have been reported for the amino acid composition in honeydews of physiologically different aphids [@pone.0070316-Fischer1]. Fungi are able to metabolise various complex


Composition {#s4e}
-----------------------------------------------------------------

Despite the widespread distribution of sooty mould, one might expect that sooty mould fungi are influenced by the external environment. Lake Rotoiti is located in the subalpine zone with low annual temperatures, high annual rainfall and highly acidic soils ([Figure 1](#pone-0070316-g001){ref-type="fig"}). In contrast, Mt Richardson is situated in the low Canterbury hills characterised by moderate mean annual temperatures, an overall drier climate and less acidic soils ([Figure 1](#pone-0070316-g001){ref-type="fig"}). The presence of similar sooty mould communities at these two diverse sites suggests that environmental variables have a low level of influence on these fungi. However, it is important to note that only a few samples from two sites were included in this study and there may be underlying factors, which at this stage are not apparent, that confoundGETTING NEAR TO THE ELECTION.

Hello folks, how are you? well we have seen a few debates so far on the coming General Election, so who do you fancy?For many Years I voted Labour but after hearing today's manifesto from Labour its highly unlikely I will be voting for them.Why? It was all going so well until Jeremy Corbyn decided to have a Free run of Migrants into the UK, for me thats a no no.This Country is struggling to make ends meet, the people of Great Britain cannot find work as it is, cannot get a home, cannot get their kids into school, cannot make ends meet, and this jumped up weirdo decides that free movement is a good thing? yes its a good thing for skilled workers,


different (non-sampled) animals for each new time point. Therefore, the remaining 20 rats were immediately transferred to an environmental chamber and stored at a temperature of constant 20 °C. Humidity was monitored during the experiment and varied between 40 and 60%. At 24, 48, 72, and 96 hpm, five randomly chosen animals, respectively, were removed from the chamber and muscles were sampled as described above. For proteomic analyses, in ten randomly selected rats (*n* = 2 at each time point), a second adjacent muscle sample was excised and prepared as described. To analyze a second species on proteomic level, ten adult female ICR mice were euthanized by cervical dislocation. At each time point (0, 24, 48, 72, and 96 hpm) the M. vastus lateralis from two randomly chosen mice were harvested,96 hpm in all tested rat groups (*n* = 5 for each group). Asterisks (\*) indicate significant decreases of band intensity (relative abundance), as determined by Kruskal-Wallis test (*p* \< 0.05). Data represented as mean ± SD

Analysis of postmortem GAPDH band patterns resulted in distinct single bands at approximately 40 kDa (Fig. [4](#Fig4){ref-type="fig"}a). Bands with an intensity of \> 5% of the native band were detected in all tested animals within the investigated time period of 96 hpm, and thus no correlation with the PMI could be calculated using these strict standard criteria of a significant qualitative change. However, there was a decrease of band intensity already at 24 hpm (mean 59.8% ± 2.9% of the native band) (Fig. [3](#Fig3){ref-type="fig"}b). This trend continued throughout the investigated period of 96 hpm and reached significance levels at 48 and 96


– The New York Giants trade Sam Leslie to the Brooklyn Dodgers for Watty Clark and Lefty O'Doul.
June 17 – The Philadelphia Phillies trade Hal Lee and Pinky Whitney to the Boston Braves for Wes Schulmerich and Fritz Knothe.

July
July 2 - The New York Giants' Carl Hubbell tied an MLB record for the longest shutout when he needed 18 innings to beat the St Louis Cardinals 1-0.
July 6 – The first Major League Baseball All-Star Game was held in Comiskey Park, Chicago, home of the Chicago White Sox. The American League defeated the National League, 4-2, highlighted by Babe Ruth's third inning home run
July 19 – Rick & Wes Ferrell become the first brothers on opposing teams to hit home runs in the same game, as Wes' Indiansbases (365), slugging (.602), on-base % (.422) and OPS (1.025), and finished second in runs (102) and fourth in stolen bases (15), is the only player in major league history to be traded after a Triple Crown season.

December
December 12 – The Philadelphia Athletics trade Lefty Grove, Max Bishop, and Rube Walberg to the Boston Red Sox for Bob Kline, Rabbit Warstler and $125,000. They also send Mickey Cochrane to the Detroit Tigers for Johnny Pasek and $100,000, then package Pasek with George Earnshaw, and send them to the Chicago White Sox for Charlie Berry and $20,000.
December 20 – The Washington Senators trade Goose Goslin to the Detroit Tigers for John Stone.

Movies
Elmer, the Great

Births

January
January 1 – Gene Host
January 2 – Bill Oster
January 4 – Ramón Monzant
January 6 – Lenny


the homotopy type of the suspension of pointed $d_k$-dimensional sphere, where $d_k:=\sum_{i=1}^k \dim\ker(\lambda_i I -A)$. For more details on Conley index we refer the reader to [@MR511133], [@MR637695], [@MR910097], [@MR688146]. In this case $K_\infty$ is a maximal compact invariant set, but it is no longer a global attractor. To be more precise, up to some admissible homotopy, the dynamics of the equation in a neighborhood of $K_\infty$ is similar to the dynamics of an isolated invariant set with $d_k$-dimensional unstable manifold.

If we assume that the equation is at [*resonance at infinity*]{}, that is, $$\ker(\lambda I - A_2)\neq \{0\} \text{ \ and \ } f \text{ \ is a bounded map,}$$ then the problem of existence of a nonempty maximal compact invariant set seems to be not considered so[@MR1389086] for an extensive discussion on the meaning of resonance in the oscillations of suspension bridges. To explain the methods that we will use in this paper more precisely, observe that the equation can be written in the following form $$\label{row-hyp}
    \dot w(t) = -\A w(t) + \F(w(t)), \qquad t > 0,$$ where $\A:\E\supset D(\A)\to\E$ is a linear operator on the space $\E:=X^\alpha\times X$ given by $$\begin{aligned}
D(\A) & :=\{(x,y)\in \E \ | \ x + c y\in D(A)\} \\
\A(x,y) & :=(-y,A(x + c y) - \lambda x) \ffor (x,y)\in D(\A),
\end{aligned}$$ and $\F: \E\to\E$ is the map defined by $\F(x,y):=(0,F(x))$ for $(x,y)\in\E$. Assume that, for every initial data $(x,y)\in \E$, the equation admits a unique mild solution $w(\,\cdot\,; (x,y)):[0,+\infty)\to \E$ starting at $(x,y)$. Then, we can


continuously embedded in a Hilbert space $H$, equipped with a norm $\|\cdot\|_H$ and a scalar product $\<\,\cdot\, , \,\cdot\,\>_H$, such that the operator $A$ has self-adjoint extension $\widehat{A}:H \supset D(\widehat{A}) \to H$. We say that condition $(G1)$ is satisfied provided $$\ \left\{\begin{aligned}
& \text{for any balls } B_1\subset V\cap X^\alpha, \ B_2\subset \ker(\lambda I - A) \text{ there are } R,\rho > 0 \text{ such that } \\
& \<F(x + y), x\>_H > - \<F(x + y), z\>_H + \rho \\
& \text{for } (y,z)\in B_1 \times B_2 \ \text{and} \ x\in \ker(\lambda I - A) \text{ with } \|x\|_H\ge R.
\end{aligned}\right.$$ In the similar way, we say that condition $(G2)$ is satisfied provided $$\ \left\{\begin{aligned}
& \text{for any balls } B_1\subset V\cap X^\alpha, \ B_2\subset \ker(\lambda I - A) \text{ there= \{\lambda_i\}_{i\ge 1} \text{ and } \dim_\C \ker\,(\lambda_i I - A_\C) < +\infty \quad\text{for} \quad i\ge 1,$$ where $A_\C$ is the complexification of the operator $A$ (see [@MR1345385], [@MR1204883] for more details). Furthermore the sequence is finite or $|\lambda_i|\to +\infty$ as $n\to +\infty$. Since $\lambda_i\in\sigma_p(A)$ we have also that $\lambda_i\in\sigma_p(\h A)$, for $i\ge 1$, as a consequence of $(A3)$. But $\h A$ is a symmetric operator, which implies that $\lambda_i$ are real numbers. Since the operator $A$ is positive, the sequence $(\lambda_i)_{i\ge 1}$ is also positive and $\lambda_i\to +\infty$ as $i\to+\infty$. Hence, in view of the right part of , we obtain $\dim (\lambda_i I - A) < +\infty$ for $i\ge 1$. $\square$

Let us introduce the space $\E:= X^\alpha\times X$ equipped with the norm $$\|(x,y)\|_\E:= \|x\|_\alpha + \|y\|


\ffor (x,y)\in \E.$$ We proceed to study the spectral properties of the operator $\A:\E\supset D(\A)\to\E$ given by the formula $$\begin{aligned}\label{op-hyp}
D(\A) & :=\{(x,y)\in \E = X^\alpha\times X \ | \ x + c y\in D(A)\}, \\
\A(x,y) & :=(-y, A(x + c y) - \lambda x) \ffor (x,y)\in D(\A),
\end{aligned}$$ where $\lambda$ is a real number and $c > 0$. Let us now proceed to study the spectral decomposition of the operator $\A$. We will need the following proposition.

[*([@Kok2 Theorem 2.3])*]{}\[th:10\] Let us denote by $\lambda := \lambda_k$ the $k$-th eigenvalue of $A$ and let $X_0 := \ker (\lambda I - A)$. Then there are closed subspaces $X_+$, $X_-$ of $X$ such that $X = X_+\oplus X_-\oplus X_0$ and the following assertions hold.\

1.  We have the following inclusions $$X_-\subset D(A),Proposition \[th-spec-dec\].

-   We have the following inclusions $S_\A(t) \E_i \subset \E_i$ for $t\ge 0$ and $i\in\{0,-,+\}$. In particular, for any $t\ge 0$ and $z\in \E$ $$\label{ds1-hyp}
    S_\A(t)\P z = \P S_\A(t)z \quad\text{and}\quad S_\A(t)\Q_\pm z = \Q_\pm S_\A(t) z.$$

-   The $C_0$ semigroup $\{S_\A(t)|_{\E_-}\}_{t\ge 0}$ can be uniquely extended to a $C_0$ group on $\E_-$ and there are constants $M, \delta > 0$ such that $$\begin{aligned}
    {2}\label{nieee1}
    \|S_\A(t)z\|_\E & \le M e^{- \delta t} \|z\|_\E && \quad\text{for}\quad z\in \E_+, \ t\ge 0, \\ \label{nieee2}
    \|S_\A(t)z\|_\E & \le M e^{ \delta t} \|z\|_\E && \quad\text{for}\quad z\in \E_-, \ t\le 0.\end{aligned}$$

-   If $\A_0:\E_0 \to \E_0$ is a part of $\A$ in $\E_0$, then $$\begin{aligned}\label{dss1}


 If sequences $(x_n,y_n)$ in $\E$ and $(s_n)$ in $[0,1]$ are such that $(x_n,y_n)\to (x_0,y_0)$ in $\E$ and $s_n\to s_0$ as $n\to +\infty$, then $$w(t;s_n, (x_n,y_n)) \to w(t;s_0, (x_0,y_0)) \aas n\to +\infty,$$ for $t\ge 0$, and this convergence in uniform on bounded subsets of $[0,+\infty)$.

-   Let $N\subset\E$ be a bounded subset and let sequences $(s_n)$ in $[0,1]$, $(t_n)$ in $[0,+\infty)$ and $(z_n)$ in $\E$ are such that $t_n\to +\infty$ as $n\to +\infty$ and $$w([0,t_n]\times\{s_n\}\times\{z_n\})\subset N \ffor n\ge 1.$$ Then the set $\{w(t_n; s_n, z_n) \ | \ n\ge 1\}$ is relatively compact in $\E$.

**Proof.** The proof of point $(a)$ is a consequence of [@MR610244 Theorem 3.3.3] and [@MR610244 Corollary 3.3.5]. Points $(b)$ and $(c)$ are consequences of [@cw-kok1 Proposition 4.1]. Proof of point $(c)$ can beinfer that $$\begin{aligned}
\<u_0(t), c \lambda y_0\>_H + \<v_0(t), y_0\>_H & \le \|(u_0(t), v_0(t))\|_{\E_0} \|(c\lambda y_0, y_0)\|_{\E_0} \\ & \le c_2\|w(t)\|_\E \|(c\lambda y_0, y_0)\|_{\E_0}.\end{aligned}$$ Since the orbit $w$ is bounded, it follows that the left side of is bounded for $t\ge 0$. This is a contradiction with $\|y_0\|_H > 0$ and the proof is completed. $\square$

To overcome difficulties presented in Remark \[rem-non-ex3\] we impose additional conditions on the nonlinearity $F$. Recalling that $X^\alpha_+$, $X^\alpha_-$ and $X_0$ are subspaces from Remark \[rem-proj\], we equip the spaces $X^\alpha_+\oplus X^\alpha_-$ and $X_0$ in the norms $\|\cdot\|_\alpha$ and $\|\cdot\|_H$, respectively. Then we introduce the following geometric conditions:\
$$\leqno{(G1)}
\ \left\{\begin{aligned}
& \text{for any balls } B_1\subset X^\alpha_+\oplus X^\alpha_- \text{ and } B_2\subset X_0 \text{ there are } R,\rho > 0 \text{ such that } \\
& \<F(x


a closed isolating neighborhood $N\subset \E$, admissible with respect to $\Pphi$ such that $K_\infty=\inv(N,\Pphi)$ and the following assertions hold:

1.  if $(G1)$ holds, then $h(\Pphi, K_\infty) = \Sigma^{d_k}$,\

2.  if $(G2)$ holds, then $h(\Pphi, K_\infty) = \Sigma^{d_{k-1}}$.

Here $d_l:=\sum_{i=1}^l \dim\ker(\lambda_i I - A)$ for $l\ge 1$ with the exceptional case $d_0:= 0$ and $h$ denotes the Conley index.

Observe that $d_l$ is a finite number because by Remark \[rem-pom\], we have $\sigma(A)=(\lambda_i)_{i\ge 1}$ and $\dim\ker(\lambda_i I - A) < +\infty$ for $i\ge 1$. $\square$

Preparation to the proof of Theorem \[th-lan-laz\]
--------------------------------------------------

In the proof we will use the following family of differential equations $$\label{roww1}
\dot w(t) = - \A w(t) + \G(s,w(t)), \qquad t > 0$$ where $\G:[0,1]\times \E \to \E$ is a map defined by $$\G(s,(x,y)):= (0,G(s,x)) = (0, PF(s Q x|w_1|\le R_4, \ |w_2|\le R_2\}.\end{aligned}$$ **Step 2.** We show that $N$ is an isolating neighborhood for the family $\{\Ppsi^s\}_{s\in[0,1]}$. To this end we prove that every bounded orbit $w:\R\to\E$ of the semiflow $\Ppsi^s:\E\to\E$, where $s\in[0,1]$, is contained in the interior of the set $N$. The choice of $R_1$ and the boundedness of $w$ in the space $\E$ gives $\Q w(t)\in \inter N_1$ for $t\in\R$. Hence, it is enough to show that $\P w(t) \in \inter N_2$ for $t\in\R$. First observe that from we have $\Q w(t) = (Q u(t),Q v(t))$ for $t\in\R$, and hence implies that $\|Q u(t)\|_\alpha + \|Q v(t)\| \le R_1$. This in turn gives $$\label{ineq2}
\|Q u(t)\|_\alpha \le R_1 \ffor t\in\R.$$ Let us define the map $(w_1,w_2):\R\to\R^{2n}$ by the formula $$(w_1(t),w_2(t)):= W\P(w(t)) = W(Pu(t),Pv(t)) \ffor t\in\R.$$


-\infty$ then by the continuity $|w_2(t_1)| \ge R_2$ and, by and , we find that $$\frac{d}{dt}\frac{1}{2}|w_2(t)|^2_{| t=t_1} \le - c\lambda |w_2(t_1)|^2 + m_1 |w_2(t_1)| \le -c\lambda R_2^2 + m_1 R_2 < 0.$$ Hence, there is $\delta > 0$ such that $|w_2(t)| > R_2$ for $t\in(-\delta + t_1, t_1)$ which contradicts the fact that $t_1 > -\infty$ and gives $t_1 = -\infty$. It follows that $|w_2(t)| \ge R_2$ for $t \le t_0$ and, using again, we obtain $$\frac{d}{dt}\frac{1}{2}|w_2(t)|^2 \le - c\lambda |w_2(t)|^2 + m_1 |w_2(t)| \le -c\lambda R_2^2 + m_1 R_2 := K < 0 \ffor t\ \le t_0.$$ Integrating this equation we have $$|w_2(t_0)|^2 + 2(-K)(-t + t_0) \le |w_2(t)|^2 \ffor t\le t_0,$$ which is a contradiction because we assumed that $w$ is bounded and hence $|w_2(t)|$ is$t\in(0,\ve_1]$ and $(u(t),v(t))\not\in B$ for $t\in[-\ve_2,0)$, which proves that $W^{-1}M^i$ is contained in $B^i$.

Suppose that $(u,v):[-\delta_2, \delta_1)\to \E_0$ is a solution for the semiflow $\varphi_2$ such that $(u(0),v(0)) \in W^{-1} M^e$. Similarly as before, we define a map $(w_1,w_2):[-\delta_2, \delta_1)\to \R^{2n}$ by the formula . Then $(w_1(0), w_2(0)) = W(u(0),v(0))\in M^e$, which together with and gives $$\begin{aligned}
\frac{d}{dt}\frac{1}{2}|w_1(t)|^2  & = \dot w_1(t) \cdot w_1(t) = a^2 \sum_{i=1}^n (c\lambda \dot u_i(t) +  \dot v_i(t))(c\lambda u_i(t) +  v_i(t)) \\
& = a^2 \sum_{i=1}^n (c\lambda u_i(t) +  v_i(t))(PF(u(t)), e_i) \\
& = a^2 (PF(u(t)), c\lambda u(t) + v(t)) \ffor t\in [-\delta_2, \delta_1).\end{aligned}$$ From it follows that $\|v(0)\|_H = |w_2(0)| \le R_2$ and $$\begin{aligned}
& ac\lambda R_3 + aR_2 = R_4 = |w_1(0)| = a \|c\lambda u(0) + v(0)\|_H \\
& \qquad \le


condition $(G2)$ implies that the set $B$ is an isolating block for the semiflow $\varphi_2$ with the boundary $\partial B$ consisting of the strict ingress points. The proof of this fact will be identical with the only difference that in the case of condition $(G2)$ the inequality will be opposite.\
**Step 4.** For any $s\in [0,1]$ write $K_s := \inv (\Ppsi^s , N)$. By Step 2 and the homotopy invariance of the Conley index (cf. [@MR910097 Theorem 12.2]) we have $$\label{eeq3}
h(\Pphi, K_\infty) = h(\Ppsi^1, K_1) = h(\Ppsi^0, K_0).$$ Let us observe that, the family $\{\Ppsi^s\}_{s\in [0,1]}$ is a homotopy between $\Ppsi^1 = \Pphi$ and $\Ppsi^0$. Furthermore, every solution $(u,v):[0,+\infty) \to \E$ of the semiflow $\Ppsi^0$ satisfies the following formula $$(u(t), v(t)) = S_\A(t)(u(0), v(0)) + \int_0^t S_\A(t - \tau)(0,PF(P u(\tau)))\d\tau \ffor t\ge 0.$$ Let us denote by $\varphi_1:[0,+\infty)\times \E_+ \oplus \E_- \to \E_+\oplus \E_-$ the semiflow given by $$\varphi_1(t,(x,y)):= S_\A(t) (x,y)\ffor t\in [0,+\infty), \ (x,y)\in \E_+ \oplus \E_-.$$ Then we can easily check that, for any $t\in[0,+\infty)$ and $(x,y)\in \E$, one has $$\Ppsi^0(t, (x,y)) = \varphi_1(t, \Q(x,y)) + \varphi_2(t, \P(x,y)),$$ which implies that $\Ppsi^0$ is topologically equivalent with the cartesian product of $\varphi_1$ and $\varphi_2$. This means that, for any $t\ge 0$ and $(z_1,z_2)\in (\E_-\oplus \E_+) \times \E_0$ $$\label{rown1hh}
    \Ppsi^0(t, U(z_1,z_2)) = U(\varphi_1(t, z_1), \varphi_2(t, z_2)),$$ where the linear homeomorphism $U:(\E_-\oplus \E_+) \times \E_0 \to \E$ is given by $$U(z_1,z_2) = z_1 + z_2 \text{ \ for \ } (z_1,z_2)\in (\E_-\oplus \E_+) \times \E_0.$$ Let us denote $K'_1:=\inv (\varphi_1, N_1)$ and $K'_2:= \inv(\varphi_2,


and $\lambda_{l-1} < \lambda + \nu < \lambda_l$ where $\lambda \neq \lambda_l$, $l\ge 2$;\

4.  condition $(SR2)$ holds and $\lambda + \nu < \lambda_1$.\

\#1[0=]{} \[2\][ [\#2](http://www.ams.org/mathscinet-getitem?mr=#1) ]{} \[2\][\#2]{}

[10]{}

S. Ahmad, *A nonstandard resonance problem for ordinary differential equations*, Trans. Amer. Math. Soc. **323** (1991), no. 2, 857–875.

A. Ambrosetti, G. Mancini, *Theorems of existence and multiplicity for nonlinear elliptic problems with noninvertible linear part*, Ann. Scuola Norm. Sup. Pisa Cl. Sci. (4) **5** (1978), no. 1, 15–28.

H. Amann, *Linear and quasilinear parabolic problems. Vol. I. Abstract linear theory.* Monographs in Mathematics, 89. Birkhäuser Boston, Inc., Boston, MA, 1995.

J. Arrieta, R. Pardo, A. Rodriguez-Bernal, *Equilibria and global dynamics of a problem with bifurcation from infinity*, J. Differential Equations 246 (2009), 2055-2080.

P. Bartolo, V. Benci, D. Fortunato, *Abstract critical point theorems and applications to some nonlinear problemsbounded nonlinear perturbations of an elliptic equation at resonance*, Nonlinear Anal. **5** (1981), no. 1, 57–60.

= 0 pt

[^1]: The researches supported by the NCN Grant no. 2011/01/N/ST1/05245


phrase “Maximum Aposteriori Probability.” The MAP algorithm provides a method for determining the most probable information bits which were transmitted based on a noisy signal received over a communication channel. It is know in the art that the MAP algorithm is an inherently Soft-Input, Soft-Output (SISO) algorithm. Soft information refers to soft-values (which are represented by soft-decision bits) that comprise information about the bits, contained in a coded sequence. In particular, soft-values are values that represent the probability that a particular bit in a coded sequence is either a one (1) or a zero (0). For example, a soft-value for a particular bit can indicate that a probability of a bit being a one (1) is p(1)=0.3. Conversely, the same bit can have a probability of being aaway from you, despite the actual knowledge you need to use any
IDE.

~~~
Noel_V
The degree course I could continue to do has some modules of questionable
value and I could learn at a faster more specific rate alone. I used to be
somewhat anti dreamweaver, and I still never use it in design view for
instance, I use it as a text editor, but as was suggested in another reply to
this post I've downloaded netbeans and I'm starting to use that. First
impressions, netbeans seems very nice.

~~~
EnderMB
I know the feeling all too well. In my opinion, a lot of degree courses are
not fit for purpose. I studied at an ex-poly that had over 15 different
Computing related courses and the only ones of real value were Computer
Science and Software Engineering.

I know for a fact that


polymerization is carried out, essentially, under anhydrous conditions. In particular, as noted in Example II, during formation of the complex, the water formed is driven off.
As can be seen, zirconium and zinc are the metals generally employed in the prior art, as they are the most effective known, for cross-linking of acidic resins and other treatments to render them useful in the coating art. While numerous variations exist as to the method of introduction, and the form, of the metal, the performance of all these products is directly dependent on stoichiometry of the metal to the resins' acidity. Primary cross-linking is the result of salt formation between the metal and the resins' carboxyl groups, though some secondary coordination with other hydrophilic groups may occur.
Many other methods exist involvingPredicting relapse in Crohn's disease: a biopsychosocial model.
Crohn's disease (CD) is a chronic relapsing inflammatory bowel disorder. Both biological and psychosocial factors may modulate the illness experience. The aim of this study was to identify clinical, biological and psychosocial parameters as predictors of clinical relapse in quiescent CD. Patients in medically induced remission were followed prospectively for 1 year, or less if they relapsed. Disease characteristics were determined at baseline. Serum cytokines, anti-Saccharomyces cerevisiae antibodies, C-reactive protein (CRP), erythrocyte sedimentation rate and intestinal permeability were measured every 3 months. Psychological distress, perceived stress, minor life stressors and coping strategies were measured monthly. A time-dependent multivariate Cox regression model determined predictors of time to relapse. 101 patients (60 females, 41 males) were recruited. Fourteen withdrew and 37 relapsed. CRP


its high time that we learn to deal with it. This story makes an attempt to explore the actions rather than debating the subject itself.

Characters -

All the characters in this movie seem real. They are as much flawed as we all are. And thus it makes it so interesting. Because without flaws there cannot be problems, and for those problems one needs to find solutions and thus the characters evolve in the end. The best character in the movie is undoubtedly Rahul, who is balancing his life between parental expectations and personal desires. He is complex beyond imagination because he has to constantly pretend to be someone else. That makes him unusually rude at times when he displays his frustration. I think, the character of the mother isI am enjoying my long marriage. I recommend marriage with the caveat that you have to bring the capacity to love or the willingness to learn to love to the marriage.

After my many years of marriage, I have come to believe that "the capacity to love" is a combination of selflessness, egolessness and self-respect. It is a tricky balance, but the exercise of finding that balance prevents boredom and keeps lovers aware and engaged in their relationship.

The maxim "talk is cheap" does not apply to lovers. While a good relationship requires action and not just "talk," in my opinion, "talk" is the means through which most couples who succeed in marriage or long relationships strengthen their relationship.

I'm not a huge Edwards fan but at least he doesn't have


   I.

       The parties do not dispute the relevant facts.

       In February 2003, Dodge began work as an at-will technology

sales account manager for CDW-G.                  When Dodge joined CDW-G, she

received      a    document    entitled      “Welcome      to    the   CDW-G   Account

Management         Team”     (hereinafter         “Welcome       Document”),   doing    so,       CDW-G    reduced    by    $60,000     the

“adjusted       gross    profit”        figure       used    to   calculate         Dodge’s

commission; the reduction assertedly reflected the contributions

of another CDW-G employee.

       CDW-G did not begin to ship the Monitors until at least

late April 2005.           According to the matrix distributed at the

2004 presentation, Dodge should have received a 19% commission

on   the


Dodge’s
claim regarding the Monitor Sale is time-barred.      Because we
hold that CDW-G had no contractual obligation to pay Dodge any
commission, we do not reach these arguments.

                                            5
Powder Co. v. Brookfield, 53 S.E.2d 804, 808 (Va. 1949).                   But

not every statement professing an employer’s future intention to

pay benefits commits that employer to a binding contract.          get promoted as quickly as possible to maximize your chances of hitting the highest League and getting the most rewards, you’re also going to face incredibly tough opponents as you get promoted to higher and higher Leagues. (And they’re also going to face you!)Players will get rewards from each Grand Arena round, from each match, from completing Feats, and from the end of the Championship. The end of Championship rewards are rewards that you can redeem for Gear 12 finishers and other high-end gear for your collection (more details to follow in the coming days).For now, there are 5 Leagues in total – Carbonite (the starting League), Bronzium, Chromium, Aurodium, and the top League, Kyber. Hitting Kyber League is incredibly challenging and will require the player to win


Times reported. In turn, “the news media picked up on details about the C.I.A.’s Kremlin sources.” Under ordinary circumstances, the intelligence community would likely not have been as definitive, but of course it was under attack by Trump, who continued to deny its conclusion that Russia was without a doubt involved in attempting to sway the 2016 election Trump’s way. Did the intelligence community go overboard, or was its revelation necessitated by Trump’s false insistence that the intelligence was not conclusive?

AD

AD

Second, the impression given to allies and to potential recruits is hugely damaging. Max Bergmann of the Center for American Progress tells me that if potential recruits fear “intelligence can’t keep their identities a secret from the President,” they’ll be hesitant to risk their lives. Likewise, foreign intelligencewanting to mess with everyone’s mind. If this was a Buk attack on MH17 then it is very farfetched that it was just an “oops” kind of thing happening in the fog of war. Basically MH 17 was positioned ( and probably was not the only plane to have been so positioned ) to be at a certain place and at a certain time and many, many people know that. But “probably” ..”maybe” ..”kind of ” does not do what needs to be done for justice to be served.

…..” The haste in pushing the adoption of a resolution and its extended scope of reference seem to indicate that the UN Security Council is being used to find a pretext for using the MH17 tragedy to organize a ‘trial’


“roaming about Rassypnoe” [a nearby village] and a commander ordering his men go and get him immediately.

One of the rebels is also wondering who and why they [the Boeing] was given permission to fly over the warzone.

The four-minute clip shows rebels searching the debris for black boxes and finding one, as well as personal IDs of the passengers, which they then filmed on the camera.

The article has the short 4 minute version of the video footage embedded, but it’s at youtube and youtube running their usual childish zionazi gay games to block viewing it. It’s marked “discretion advised”, but when you OK it for viewing, you get the “oops, something went wrong” message and no video plays. The transcript at new.com supposedly is for the full 17 minutescrambled — so there is no excuse not to show the video on Youtube except to censor the information. But of course — why would google allow a video which clearly refutes the empire’s false narrative.

I’m surprised the transcript was available, even though the translation might not tell the whole story that which it does tell is pretty damning to the empire, supporting that MH17 was shot down by the fighter jet.

The truth is being established despite the imperialist MSM attempts to spin and censor.

The Russians early on provided factual info of a Su being in close proximity of MH-17 when it was shot down. At the time, they didn’t make any official claims as to what brought the plane down. That’s changed, the Russians now consider the


damages in the form of localized puncture holes and surface dents typical for hypervelocity impacts with compact and hard objects,” the report says, stressing that similar damage could be found on the inner side of the cockpit.

The report specifically points out that chips of the body coat around the holes in the fragment are typical of wave effects created by hypervelocity impacts.

Some damage, though larger and less clustered, could be found near the air-scoop of the left-wing engine of the aircraft.

Apart from the large puncture holes, the debris of the nose and the cockpit of the aircraft bear a large number of scattered micro-craters resulting from the impact of high-velocity dust and tiny debris, such as an unburnt blasting agent and elements of the ordnance that accompany apeople in the west have no idea about of this war crime. Give them the details, one would be surprised to the degree people in the west, tired of the gay zionazi-nazi horse manure, really hunger for those details – those never mentioned in the zionazi media facts that many suspect exist, but are at a loss about where to find them.

I personally like this version as the BUK never made sense in the launch noise, lack of (credible) witnesses/no smoke trail/shape and large size of shrapnel/need for additional radar control BUK vehicle for target solution at FL320 plus expert BUK system knowledge needed to operate.

Launched from an SU-25 that was definitely in the vicinity ( or other fighter) the air-to-air missile scenario can only mean that junta


does one greet an officer, Hans?”
“If he’s German, you raise one arm, if Russian, you raise two…”

“Ukraine accuses Aidar commander Melnychuk of establishing a criminal organization”
“But…Nadezhda Savchenko served in that battalion”
“Does it mean she received Hero of Ukraine award as a member of a criminal organization?”

Ministry of Health Warning:
“Fighting against Russians is hazardous to your health.”

“The Airborne Forces are not the Ministry of Health–they don’t issue warnings.”

Sorry this is off topic but there have been a lot of rumors about DPR being “reorganized” these are from Kazzura:

Few things, that are sad and that have been obvious for a while, however maybe it’s obvious only here:
— DPR ministry of defense is abolished
— DPR Republican Guard is disbanded, its units are part of DPR army corps aka “DPR People’s Militia”
—boots on the ground.

Everything in Ukraine is connected to other points of conflict between Russia, NATO, and the US.

That’s a bit of what you don’t get from the rumor millers.

Cassad has his daily update on the subject today. Fresh. None of this rumor stuff is correct.

And maybe Butler is back in Gorlovka. Not confirmed. But that would be very good. He’s a cruel dude, fearing no one.

I’ve seen that too.I think we need more information on it.It would be a literally fatal mistake for the Russian government to betray Donbass.The return of thousands of battle-hardened angry Russian fighters to Russia would be the beginning of the end of the government that betrayed them.Any political leaders able to credibly claim that the current Russian government betrayed them would become


an foreign war with the fraternal Russian people (whom the Rusyns have always warmly treated) for unclear to us interests. Then Rusyns first loudly declared about themselves, there have been a number of attacks on military commandant’s offices, the enlistment papers to the so-called “anti-terrorist operation zone” were burned, and our guys prepared for slaughter have been taken back from the Ukrainian butchers, that’s when the first “friendship train” of the Right Sector came to “deal with the traitors”, but met with resistance, pravoseki shamefully retreated (by the way no more call up papers came to us – it is a note to those who are also forced to go to this stupid war). As it turns out, they have not forgotten this…

Right Sector has long together with9M38M1 missiles at the fuselage of a decommissioned plane, similar to the one that crashed on July 17, 2014 in the skies over Ukraine (flight MH17).
[…]

This is off topic, but I just would like to know the opinion if it is a legitimate site or just dragging money from the world population

Dear friends,

The hopes of the whole world rose when the Greek people stood up to the senseless and devastating policy of austerity, but now Germany has forced their leaders to accept even worse austerity as punishment for their defiance! It’s up to us to make sure this isn’t over…

Germany’s Angela Merkel seems like a heartless, anti-democratic tyrant, but really she is doing what the majority of the German people want her to do, and what she believes


feudal reward scheme. It was supposed to be the Ukrainian railroads, Ukrainian coalmines that were supposed to be taken over by German (and, to a lesser extent, Polish) interests. Well, that ship not only has sailed, it was blown up by a Russian torpedo and is now resting in a very deep part of the ocean. So what is Germany to do? One thing it can do is cannibalize another lower category vassal which is not as important to the US as Germany itself is. So now it’s Greece, Italy, Spain, Portugal and, yes, Poland on the chopping block. Hannibal’s armies, unable to despoil Roman provinces, are reduced to despoiling the provinces of its allies who were attracted by the prospect of a victorious march on Rome. What’sworse, Hannibal’s allies are actually starting with one another, so that he now has his hands full trying to keep various components of his vast army from killing one another. In the final account, what happened to Hannibal’s diverse and ally-heavy army as a result of this turn of events is a lot like what is happening in the relationship that America has with its lesser and greater vassals (though note that in most Polish articles Germany’s power magnified by its proximity is such that it eclipses America’s superior but more distant power) as well as in the relationship among the vassals. Notice the rather futile US effort to get Germany to go easy on Greece.

How does the feudal lord and/or the more powerful of its vassals respond?


their main product. In this country the Murdoch cancer controls 70% or so, and the bias, bigotry and hatred is 100%-the true meaning of ‘Free Press’ and ‘Je Suis Charlie’.
Hence the anniversary of the MH17 disaster has been the excuse for truly deranged anti-Russia, anti-Putin hatemongering. They all look over their shoulders, mentally, to see if Rupert, a Devil Incarnate, approves, so the ferocity only ever increases. In the rest of the MSM the bias is the same, the Free Press always speaking with 100% Groupthink, but the hysteria is, usually, less. This week, however the hate spread far and wide. The hacks at the ABC, Government controlled but under ferocious attack from the far Right Abbott regime and the Murdoch cancer, were viciously propagandistic, one scum-bag eventalking of locals where the plane crashed, and who had retained pieces of debris, as showing off their ‘trophies’, as if these people somehow were celebrating the disaster. As I said, the presstitutes here are, nowadays, universally scum-bags.
One other aspect that stands out is the sheer satanic hypocrisy of these vermin. For one example, you have the Murdoch metastases screaming blue murder over these deaths, but one year ago, as the Israelis slaughtered 2000 in Gaza, including 500 children, the same vermin were urging Israel on and vilifying the victims. And, naturally, the victims of the Ukrainian Nazi regime, in the Odessa massacre and elsewhere in eastern Ukraine, are NEVER mentioned. They have gone straight down the Memory Hole.

‘Je Suis Charlie’ is for Zionazi hate-mongers only. And don’t


2015, the agreement was sealed through the announcement of a formal opening date of July 20 for the embassies. It is important to note that over the course of this two-year process, Cuba has not given up its principles. Two primary examples of Cuba sticking to its precepts pertain to the contentious issues of democracy/human rights and of Venezuela.

“That group is pulling together significant evidence on one dominant theory: “That there was a BUK rocket fired from the eastern part of Ukraine, the theory in which we have the most evidence,” says Fred Westerbeke, the Dutch chief prosecutor.

That conclusion is not a surprise — the U.S. said from the outset that it was a Russian-built BUK surface-to-air missile that brought down the airliner. So did Ukraine. But Westerbeke’s10-15 minutes of advertising, and it’s bad advertising too. That seems to be the main difference. They used to have these women come through and sell candies from their carried carts. Not this time. This cinema only showed Hollywood fare with one Indian exception. It was like being anywhere in the United States, really. Except the money is worth twice as much and so it’s all a little more painful.

But I was there to see the big summer movie anyways, so I guess it didn’t matter. I’d not seen the “original” Pirates movie on the big screen, I think because I had a small child at the time. It had been a surprisingly fun film, as many had said and enjoyed, and though I had heard mixed things


son of Houlka came Friday for Miss Mary K. Shaw who will spend the holidays at home.

Mr. and Mrs. Carl Shaw of Embry were weekend visitors with Misses Effie and Lee Ransom.

Mr. and Mrs. Duel Watson of Calhoun City are visiting his parents, Mr. and Mrs. J.F. Watson.

Mr. and Mrs. Carl Richardson of Natchez visited his parents and Miss Sammie T. Richardson returned home with them for a week’s visit.

Mr. and Mrs. Price Shaw were Sunday visitors with Mr. and Mrs. Bill Carroll at Embry.

Mr. and Mrs. Earl Goddard and son, E.J. of Smithville are visiting her parents, Mr. and Mrs. S.T. Richardson.

Mr. and Mrs. J.I. Lucas of Jackson were visitors Sunday and Monday with Dr. and Mrs. E.F. Arnold.

Mr. and Mrs. Earl Norwood of Clarksdale were holidaycentral premise of the book, Doing Families: Gay and (p.17) there. In other essays, the topic is considerably more Lesbian Family Practices, is that the fields of family studies focused, as in Martine Gross’s essay on “Grandparenting in and sexuality studies have been isolated from one another French lesbian and gay families.” This structure reflects with the former dealing with heterosexual families and the both the editors’ endorsement of British sociologist David latter dealing with homosexuality. It is as if, French Sociol- Morgan’s view that the word “family” should be thought of ogist Eric Fassin notes in the forward, “queers have sex, as more adjective or verb than noun (p.11) and the realities while straight folks have families” (p.7). The goal of this of post conference edited volumes.


disease. For this proposal we will determine the ec-coupling mechanisms and Gi signaling mechanisms involved in CHF and cardioprotection. Using single myocytes, cardiac trabeculae, and Langendorff perfused mouse hearts, we will determine the effect of Ro1 expression on Ca2+ transients and determine the mechanisms responsible by localizing abnormalities to specific Ca2+ handling processes. We will determine the effect of Ro1 expression on Ca2+-responsiveness and determine the mechanisms responsible by localizing abnormalities to specific contractile and regulatory proteins. Using the tet-system to turn off Ro1 expression after induction of CHF, we will determine the extent to which ec-coupling abnormalities are reversible. To elucidate signaling mechanisms, we will determine which of the major Gi pathways in the heart (Gi2 and Gi3) are involved; and whether signaling via the G protein1. Field of the Invention
This invention relates to optical data storage systems, and more particularly to such systems which have removable optical media.
2. Description of the Prior Art
Optical data storage systems such as disk drives use laser beams to record and read data from optical data storage disks. The disks are typically packaged in a cartridge for easy removal from the drive. A problem with these systems is that dust and other particles can collect inside the drive and adhere to the optical elements such as the disk or the objective lens which is used to focus light to the disk. The collection of dust and particles causes a degradation in the signal to noise ratio and can ultimately cause the disk drive to fail.
Various schemes have been


March 1991, pp. 484, by Yanker. There are also drives which contain lens cleaners. See Japanese published applications JP 01-287893, published Nov. 20, 1989, by Warisaya, et al.; JP 02-105340, published Apr. 17, 1990, by Sugano, et al.; JP 02-31339, published Feb. 1, 1990, by Miyajima, et al.; JP 62-40641, published Feb. 21, 1987, by Kitazawa, et al.; and JP 02-152028, published Jun. 12, 1990, by Suzuki, et al. PCT application W09006576, published Jun. 14, 1990 by Hake shows the use of a lens cover. U.S. Pat. No. 4,814,906, issued Mar. 21, 1989 to Suzuki, et al.; and Japanese published application JP 63-269392, published Nov. 7, 1988 by Ouguchi, et al. show examples of contamination protection schemes for magnetic disk drives.
What is needed is an optical disk driveRobotic transanal endoscopic microsurgery: technical details for the lateral approach.
Transanal endoscopic microsurgery is a minimally invasive approach reserved for the resection of selected rectal tumors. However, this approach is technically demanding. Although robotic technology may overcome the limitations of this approach, the system can be difficult to dock, especially in the lithotomy position. The study aim is thus to report the technical details of robotic transanal endoscopic microsurgery with the use of a lateral approach. This study is a prospective evaluation of robotic transanal endoscopic microsurgery in a single tertiary institution, under a protocol approved by our local ethics committee. Patients underwent a routine mechanical bowel preparation and were placed in the left or right lateral position according to the tumor location. A circular anal dilatator was used


together with the glove port technique. The robotic system was then docked over the hip. A 30° optic and 2 articulated instruments were used with an additional assistant trocar. The tumor excision was realized with an atraumatic grasper and an articulated cautery hook, and the defect was closed with barbed continuous stiches in each case. The primary outcome was the safety and feasibility of the procedure. Three patients underwent a robotic transanal endoscopic microsurgery with the use of the lateral approach. Mean operative time was 110 minutes, including 20 minutes for the docking of the robot. There was 1 intraoperative complication (a pneumoperitoneum without intraabdominal lesion) and no postoperative complications. Mean hospital stay was 3 days. Margins were negative in all the cases. The study was limited byEU Framework Programme for Research and Innovation – and it is also reflected in the agenda of the Slovenian Research Agency, which a decade ago set up a special Expert Body for Interdisciplinary Research to foster the exchange of knowledged and collaboration between disciplines. The question is to what extent these measures are successful in bringing about the desired change, in particular the dissemination and promotion of interdisciplinarity. It is namely not rare that such policies, although being developed with the best intentions, fail. A recently identified example of a similar failure is the development of an integrated European Research Area, which was thought to be a critical component for a more competitive and open European research and development system. But as [@chessa2013europe] point out, there has been


fact that interdisciplinary research has been growing proportionally with the overall growth of the collaboration network can be interpreted as a silver lining development. On the other hand, the hope would be that, in the light of the importance of interdisciplinary research and the implemented policies that favor such development, the interdisciplinarity would grow faster than average. Thus, we find that while the network and the number of communities and the links between continue to grow at a steady rate, the amount of interdisciplinary research is stalling or even slightly declining. This invites the conclusion that a healthy and flourishing interdisciplinary research environment in Slovenia is in need of additional and stronger stimulation than it has received thus far. In the future, it would be interesting to conductfrom the 1960 onwards. We use this database to construct coauthorship networks, where two researchers (considered as network nodes) are connected by an edge if, up to the given year inclusive, they have coauthored at least one paper. The edges are weighted, in the sense that if they coauthored $k$ papers, then the weight of the edge connecting them is $k$. Starting with 1960 and ending with 2010, we construct coauthorship networks by cumulating the edges among the researchers active the time period up to a given year. We term them $\mathcal{G}_t$, where $t$ indicates the ending year. The SICRIS data used are obtained on 14 December 2013.

Starting with no more than $30$ researchers with an average of $1.5$ collaborators in the year $1960$, the network to date


prevention of T2DM \[[@B50]\]. This study failed to show significant association between all the five genetic polymorphisms of RAAS genes with T2DM. The reason might be the different methods used or may occur due to racial differences or heterogeneity of the population sampling bias or possibly due to the environmental factors may contribute to the negative associations \[[@B51]\]. Moreover, despite the considerable controversy regarding the existence and importance of ethnic differences in genetic effects for complex diseases, it seems evident that genetic markers for proposed gene-disease associations vary in frequency across populations. Association studies must be repeated in this population to ensure that any association of candidate genes with T2DM is pathogenetically significant.

Study limitations
-----------------

The present study has to be interpreted within the context of its limitations. The presentWe used a computer-generated sequence via an interactive web response system to randomly assign patients to receive either pitolisant or placebo once per day (1:1 ratio). Randomisation was done in blocks of four. Participants and investigators were masked to treatment allocation. Treatment lasted for 7 weeks: 3 weeks of flexible dosing decided by investigators according to efficacy and tolerance (5 mg, 10 mg, or 20 mg oral pitolisant), followed by 4 weeks of stable dosing (5 mg, 10 mg, 20 mg, or 40 mg). The primary endpoint was the change in the average number of cataplexy attacks per week as recorded in patient diaries (weekly cataplexy rate [WCR]) between the 2 weeks of baseline and the 4 weeks of stable dosing period. Analysis was by intention to treat.


Q:

Deduplicate rows in a BigQuery partition

I have a table with many duplicated rows - but I only want to deduplicate rows one partition at a time.
How can I do this?
As an example, you can start with a table partitioned by date and filled with random integers from 1 to 5:
CREATE OR REPLACE TABLE `temp.many_random`
PARTITION BY d
AS
SELECT DATE('2018-10-01') d, fhoffa.x.random_int(0,5) random_int
FROM UNNEST(GENERATE_ARRAY(1, 100))
UNION ALL
SELECT CURRENT_DATE() d, fhoffa.x.random_int(0,5) random_int
FROM UNNEST(GENERATE_ARRAY(1, 100))

A:

Let's see what data we have in the existing table:
SELECT d, random_int, COUNT(*) c
FROM `temp.many_random`
GROUP BY 1, 2
ORDER BY 1,2

That's a lot of duplicates!
We can de-duplicate one single partition using MERGE and SELECT DISTINCT * with a query like this:
MERGE `temp.many_random` t
USING (
  SELECT DISTINCT *
  FROM `temp.many_random`
  WHERE d=CURRENT_DATE()
)
ON FALSE
WHEN NOT MATCHED BY SOURCE ANDSAN JOSE — A South Bay man is suing a former den master he claims sexually abused him in 2008 and the local Boy Scouts of America council for allegedly not intervening beforehand despite obvious warning signs.

The man at the center of the civil lawsuit, Ronald Guinto, was convicted in January of 87 of 90 counts in a separate East Bay case involving child molestation, kidnapping and dissuading his victims from testifying against him. Prosecutors said Guinto used his position as a teacher at Making Waves Academy in Richmond and founder of a youth program called Camp Epic to molest boys.

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