mother of three of my five kids!" "Anyway, this bad boy can still get up to a buck ten." "Yeah, maybe if the truck towing it was going 110." "You don't believe me, I refer you to World's Wildest Police Chases, episode 139." "Whoa, what died in here?" "My granddad." "The seat belt got jammed, we had to leave him in there for a couple of days." "Okay, well, hey, thank you for showing us the car." "Whoa, hang on, hang on." "How much do you want for it?" "Uh, uh, uh, what are you doing?" "I'll take $1,800 unless you can come up with some kind of other arrangement." "Ew!" "How about you?" "No!" "$1,800 it is, then." "I'm not..." "I'm not buying this car." "Walden, thisto ride a bike, how to shave, how to change a tire, how to masturbate." "What?" "No, dads don't teach you how to masturbate." "I'm glad somebody told me before I had kids." "This thing is actually really cool." "What made you sell it in the first place?" "I needed the seed money to start my company, and it's the only thing I had that was worth anything." "You know, when you think about it, this car is really responsible for everything I have:" "the beach house, my jet and my fortune." "Alan." "Shh, she didn't mean it." "It's not true." "So that means your dad is kind of responsible for your success, too, doesn't it?" "I never really thought of it like that." "I guess he is."


up." "Wait" " Charlie lost Jake?" "Actually, Jake lost Charlie." "Security found him." "He was doing white snow with Snow White." "So, um, what did you do to drive this girlfriend away?" "She thinks I'm still in love with Lyndsey, which I'm not, but she doesn't believe me." "Well, make her believe you." "You can make anybody believe anything." "You made the IRS believe you had seven dependents." "That's true." "I went to chiropractic college on an NAACP scholarship." "Exactly." "And you made those people at the movie theater believe that you were under 14." "And over 65." "Once on the same day." "(laughs)" "The, uh, the secret is that both of those groups wear little baseball caps." "(laughs)" "I was saving this for your funeral, but, Zippy,environment condition. Our Civil Engineer prepared your Site Mapping in take care of all advantage and disadvantage of your Project Site as well as our CA will prepared your Project Report and our highly expertise team will assist your project under supervision of highly qualified and recommended Scientist and Consultant.


as measures of effect: Pr(*D~1~* = 1\|*E~0~* = 1)/Pr(*D~1~* = 1\|*E~0~* = 0) and Pr(*D~1~* = 0\|*E~0~* = 1)/Pr(*D~1~* = 0\|*E~0~* = 0). Again, the magnitude of the probability ratios may depend on the time interval between "exposure" and "disease."

A natural path between *E~0~* and *D~1~* is any sequence of arrows, regardless of their direction, that connects the two and does not pass more than once through each variable. A causal path between *E~0~* and *D~1~* is any natural path in which all the arrowheads point toward *D~1~*, namely any path through which *E~0~* affects *D~1~* ([Figure 1](#f1-clep-5-057){ref-type="fig"}, Diagram A). A confounding path is any natural path that contains a shared cause of *E~0~* and *D~1~* on that path, such as *E* ← *C* → *D~1~* and *E~0~*cross-sectional study can be found in a prospective cohort and every structure can be found in a retrospective cohort. Regardless, scientific inquiry is not founded on the possibility of bias but on proposing an explicit theory for a particular study. A critic of a particular study should propose a structure of colliding bias -- with named variables -- and allow others to examine and criticize the criticism. It is not helpful to say that selection bias might exist in a cross-sectional study (or in any design) or that one design allows for more structures of bias than another. Generic truism is not part of empirical science.

Information bias in a cohort study
==================================

Consider a prospective cohort study of 80 women, the purpose of which is, again, to estimate the effect


required in a prospective cohort, to imputing the value of *E~0~* (drug taking) because *t* = 0 is some arbitrary historical time, 1 year earlier. That is sometimes the biggest challenge of a cross-sectional study. If *E~0~* denotes the use of a fertility drug on some index date, numerous methods of imputations are possible: (1) obtain the information from a clinic record, relying on a clinic visit that took place as close as possible to the index date. (2) Ask each woman whether she took a fertility drug on the index date. (3) Implement both of the previous methods and develop an imputation algorithm that relies on combined information.

Of course not all methods are equally accurate, but the key point is this. We cannot escape the need to\> 0. However, information bias is usually smaller for intervals Δ*t*′ close to Δ*t* and may be very large for intervals that are much smaller, or much larger, than Δ*t*.

We usually put rough limits on imputation-related assumptions. For instance, if the use of a fertility drug and pregnancy status were determined 1 year apart (Δ*t* = 1 year), we may accept the estimated effect for all time points between 10 months and 14 months (10 months ≤ Δ*t*′ ≤ 14 months), but would likely reject the estimate for Δ*t*′= 24 months. Practically speaking, the probability ratio should be computed for as many times as possible: 1 month, 2 months, 3 months, and so on. The usual constraint is the time points at which *E* and *D* were measured


and the number of people in whom they were measured. Again, there is no way to avoid the tradeoff between the magnitude of information bias and the size of the variance.

The location of selection status (*S*) after disease status (*D*) in a cross-sectional study allows *D* to be a cause of *S*. If indeed *D* → *S* (and *E* → *D*), uni-path colliding bias is present ([Figure 5](#f5-clep-5-057){ref-type="fig"}, Diagram E). Two intriguing questions may therefore be asked: should we refrain from selecting participants for a cross-sectional study on the basis of disease status? May we use the design when *D* affects *S* for reasons other than selection criteria (eg, the disease affects survival)?

Interestingly, partial answers may be found in case-control studies, where *D* → *S* by design: peoplewith the only antecedent of an elbow fracture 15 years earlier, which was treated surgically. The patient got a tattoo on the fossa of his left elbow 30 days prior to his arrival at our department.

The patient arrived at the emergency department with pain, redness, and swelling of the upper left arm in the anteromedial region, accompanied by general malaise and fever. A physical examination revealed skin redness and edema in the tattooed area, with heat on palpation. Passive and active range of motion was preserved but was very limited by the pain, without distal nervous or vascular injury. He had a measurable fever of 38.5 accompanied by a general feeling of malaise. Lymphadenopathy or systemic symptoms were not evident.

In the emergency department we performed an ultrasound, which


infections with*S. marcescens* is very low, occurring in immunosuppressed patients and almost never occurring in immunocompetent patients \[[@B2], [@B5]\].

Some cases have been reported in which previous trauma, animal bites, or the presence of ulcers can serve as routes of entry for the bacteria \[[@B6], [@B7]\]. A new case has recently been published, a cutaneous facial infection after hyaluronic filler injection in an immunocompetent patient, and trauma and poor hygiene were determined to be the causes of this infection \[[@B9]\].

The infected area that was presented in our patient had been tattooed one month earlier. This fact, in addition to the absence of immunosuppression, suggested that the trauma of the tattoo needle injected into the skin was the gateway for the infection.

Infections after getting a tattoo are rare and are
Show HN: CreatorCast: Curated Sketch Creators - michael45
https://www.creatorcast.tv/
======
michael45
Hi HN!

I just launched a project called creatorcast.tv

It's a curated selection of Youtube sketch comedy creators.

I've been a huge fan of indie sketch creators since the early days of Youtube,
but today the Youtube algo prioritizes content from influencers and Hollywood.
So I wanted to build this platform to give another way for talented sketch
creators to develop bigger audiences. Hopefully it's reminiscent of 2011's
Youtube content :)

The site is still very young and still has a lot more development work to do
but let me know if you have any feedback and if you like the content there! I
plan on adding new videos each week and building a community around creating
high quality sketch videos.


global capital of its intention to repay Greece’s debts, while carrying out some immediate measures to placate, and dupe, those who elected it in the expectation that it would carry out progressive social change. Tsipras told his cabinet that ministers “must not disappoint the voters who gave us a mandate.”

Panagiotis Lafazanis, another veteran Stalinist and leader of the party’s “Left Platform,” was handed the Ministry of Productive Reconstruction, Environment and Energy. He announced yesterday that several proposed privatisations would be halted, including the Public Power Corporation and the Independent Power Transmission Operator. The full privatisation of Greece’s biggest and strategically vital port, Piraeus, would be postponed, and 595 public sector cleaners who were fired by the last government under its “mobility scheme” would be rehired.

Most of these measures
int arrayone [5] = { 11, 12, 13, 14, 15 };

are equal to
    { 11, 12, 13, 14, 15 }
and to complete the unit test successfully if the values are equal, and to fail if they are not equal or not in the same order. Thus, i am looking for the best method to approach this.

A:

Use a C++ std::array instead and you'll get the benefit from all the methods it exposes, like operator==:
#include <iostream>
#include <array>

int main() {
    std::array arrayone{ 11, 12, 13, 14, 15 };
    std::array facit{ 11, 12, 13, 14, 15 };

    if(arrayone==facit) {
        std::cout << "true\n";
    } else {


WASHINGTON — SpaceX is gearing up for both the first launch of its Falcon 9 rocket since a June launch failure and the first flight of a “significantly improved” version of the vehicle, but questions remain about the company’s plans to attempt to recover the rocket’s first stage.

SpaceX is planning a static fire test of the Falcon 9’s first stage engines on its launch pad at Cape Canaveral, Florida, on Dec. 16. If successful, that test would clear the way for a launch attempt “about three days later,” or Dec. 19, between 8 and 9 p.m. Eastern, according to a Dec. 10 press release from Orbcomm, the launch’s customer.

SpaceX has released few details about launch preparations, but Orbcomm said in a Dec. 14 statement that the 11 second-generationQ:

Composition and Proton Flux from the Solar Wind

I am taking a class on the space environment and I have a few questions about the solar wind.  A number of sources list the composition as (approximately) 4% He$^{++}$ and 96% H$^{+}$.  What exactly does this mean?  Does it mean by mass or by number of ions?
Also, when discussing proton flux due to the solar wind at Earth:  What exactly is included in the flux numbers quoted (e.g., one source I have says 2e12 m$^{-2}$s$^{-1}$).  Is that the flux due to only the H$^{+}$ and excluding the He$^{++}$ and other minor constituents?  Or, are they including all the protons from the other ions as well?

A:

That's by number-- you get a lot more helium than


at the output of the material property network can be propagated back to the spatial scaling values. For simplicity, consider the stress $\bm{\sigma}^t(\bm{x})$ and strain $\bm{\varepsilon}(\bm{x})$ computed by FEA at a single location $\bm{x}$. The current value of ${\bm{S}_{\bm{x}}^{\varepsilon}}$ and $\bm{\varepsilon}(\bm{x})$ can be used to compute $\bm{\sigma}^{NN}(\bm{x})$, the value of stress predicted by the MPN: $R_m:\bm{\varepsilon}(\bm{x})\rightarrow\bm{\sigma}^{NN}(\bm{x})$. The goal is to minimize the objective function

\_\^ = \_[\_\^ ]{}  (\^t(), \^[NN]{}()).\[eq:spatial\_obj\]

The function $\operatorname{f_m}(\cdot)$ is the $L_2$ norm:

= E &= \_[i=1]{}\^[3]{}(\_i\^t() - \_i\^[NN]{}())\^2\[eq:loss\_func\]\
&= \_[i=1]{}\^[3]{}e\_i\^2,

where (dropping $(\bm{x})$ for brevity)

\_i\^[NN]{} &= S\_\_[i]{}’\^[,NN]{}\
\_j &= [S\_[\_i]{}\^[\_j]{}]{}\_j’\
e\_i &= \_i\^t - \_i\^[NN]{}.\[eq:stress\_error\]

We define $\sigma_k^t$ as the $k^{th}$ component[^1] of “target” stress at $\bm{x}_i$, $\sigma_k^{NN}$ is the corresponding stress component predicted by the MPN in response to $\bm{\varepsilon}$, and $(i,j,k)$ have the range $(1,2,3)$. Scaled input and outputswas implemented in our previous study with AutoP [@hoerig2017]. Finally, we trained the MPN over 50 epochs with ${\bm{S}_{\bm{x}}^{\varepsilon}}= \bm{1}$ and ${\bm{S}^{\sigma}}= 1$.

After generating all data sets and pretraining the MPN, we used the stress-strain data from all four load increments in each set to compute new spatial scaling values using Alg. 1 ($N = 150$, $N^{\sigma} = 8$ due to frame invariance, $\eta = 2.5$). Spatial networks were trained for each model using the newly computed [$\bm{S}_{\bm{x}}^{\varepsilon}$]{}. Each network was comprised of five hidden layers with 25 nodes per hidden layer. Training was split into iterations to mimic what occurs in AutoP. For example, instead of simply training the SN over 12000 epochs, we split training into iterations where fewer epochs were used. 10 iterations of 300 epochs were


and the axial component of the computed stress ($\sigma_{22}$) were used to compute the spatially varying Young’s modulus $E(x,y)$ by inverting the plane-stress equation:

E(x,y) =

where $\nu = 0.5$. The choice of strain vector is arbitrary so long as it resides within the range of training data. Selecting small values for each component ensured the strain was within said range.

[0.23]{} ![The left-most column contains the minimum, maximum, and mean RMS error curves from Alg. 1 while computing the values of [$\bm{S}_{\bm{x}}^{\varepsilon}$]{} for each of the seven cases. Columns 2-4 are the resulting $S_{\bm{x}}^{\varepsilon_1}$, $S_{\bm{x}}^{\varepsilon_2}$, and $S_{\bm{x}}^{\varepsilon_3}$ distributions, respectively.[]{data-label="fig:computed_scaling"}](./Slide1_c.pdf "fig:"){width="\textwidth"}

[0.23]{} ![The left-most column contains the minimum, maximum, and mean RMS error curves from Alg. 1 while computing the values of [$\bm{S}_{\bm{x}}^{\varepsilon}$]{} for each of the seven cases. Columns 2-4 are the resulting $S_{\bm{x}}^{\varepsilon_1}$, $S_{\bm{x}}^{\varepsilon_2}$,Target and [CaNNCM]{} modulus estimates for no added noise, 10% added noise, and 30% added noise along $y = -6.3$ of the kidney model. (h) Young’s modulus value for abdominal MRI model along the diagonal.[]{data-label="fig:line_comp"}](.//three_inc_line_comp.pdf "fig:"){width="\textwidth"}

[0.23]{} ![(a-d) The white lines indicate the locations where Young’s modulus cross-section comparisons occur. (e) Target and [CaNNCM]{} Young’s modulus along $x = 0$ for single inclusion model. (f) Young’s modulus values along $y = 0$ for three inclusion model. Test 3 refers to the case where Mesh 2 and Test 1 parameters were used. (g) Target and [CaNNCM]{} modulus estimates for no added noise, 10% added noise, and 30% added noise along $y = -6.3$ of the kidney model. (h) Young’s modulus value for abdominal MRI model along the diagonal.[]{data-label="fig:line_comp"}](.//kidney_line_comp.pdf "fig:"){width="\textwidth"}

[0.23]{} ![(a-d) The white lines indicate the locations


noise added to target Young’s modulus distribution. (b) Uniformly distributed noise added to target distribution.[]{data-label="fig:app_1"}](./method_2.pdf "fig:"){width="\textwidth"}

[^1]: There are three components in the stress vector for 2-D models, ordered as $[\sigma_{11},\ \sigma_{22},\ \sigma_{12}]$. The same ordering is used for the strain vector.
the larger events that happen, like Irish Day or the Polar Bear plunge, those best practices have been employed,” Kilmnick said. “Planning has been, contrary to rumors, taking place for a good nine months. We feel very comfortable that things are going to go very smoothly and everyone is going to have a good time.”


discrete ones, is that, in the case of the attractive local nonlinearity, they account for the onset of the collapse even in the framework of the 1D description (recall that the GPE with the self-focusing cubic term does not give rise to the collapse in 1D).

The BEC dynamics is strongly affected by long-range interactions in *dipolar condensates*, which can be formed by chromium atoms in an external magnetic field, as shown in experiments [@Cr]. In particular, the dipole-dipole (DD) attraction in the condensate gives rise to a specific ($d$-wave) mode of the collapse in the condensate [@d-collapse]. Nevertheless, the dipolar condensate can be stabilized against the collapse, adjusting the scattering length of the collisional interactions via the Feshbach-resonance technique [@experim1]. It was also proposed to create a condensatea modified Powell minimization method, which uses a finite-difference expression for the underlying Jacobian. In the analysis reported below, we focus on the three most fundamental unstaggered localized modes (staggered" are configurations with opposite signs of the field at adjacent sites, which is relevant to local models with the repulsive nonlinearity): *on-site* modes, i.e., those centered on a lattice site, *inter-site* ones, which are centered between lattice sites in both directions $m$ and $n$, and *hybrid modes*, centered on-site along one lattice direction, and between sites along the other. This nomenclature was adopted in previous studies of local discrete models [@pgk2dfund]. Results reported below were obtained using a square lattice composed of $11$x$11$ or $21$x$21$ elements for on-site modes, and of $10$x$10$ or $20$x$20$ elements for inter-site and


$\mu <-1$ and $\mu <0$ in the DGPE and DNPSE model, respectively), and they have their counterparts ion the local model. These localized structures, such as the one displayed in Fig. (\[fig8\]) for the DNPSE, remain “frozen” under the action of arbitrary perturbations.

The evolution of all the unstable fundamental solitons considered in the previous subsections follows approximately the same scenario, in the presence of the DD interactions. Direct simulations of Eqs. (\[DNPSE\]) and (\[DGPE\]) demonstrate that the outcome of the evolution under the action of perturbations is the emergence of persistent strongly pinned on-site breathers, surrounded by a finite oscillating background, see an example for the DNPSE in Fig. \[fig9\]. The evolution may feature different transient stages, depending on the initial structure. For example, unstable on-site solitons directlythese discrete 2D solitons appear exactly in a part of the parameter space where the CW states are modulationally unstable (this is shown in detail in Ref. [@acta]). This region belongs to the semi-infinite gap of the linear spectrum, which corresponds to $\mu <0$ and $\mu <1$, in the GPE and NPSE models, respectively. Again, three families of fundamental unstaggered discrete solitons – of the on-site, inter-site, and hybrid types – have been found in this situation as numerical solutions of stationary equations (\[TdSNPSE\]) and (\[TdSGPE\]) for the DNPSE and DGPE models, respectively.

It is relevant to emphasize that the solitons are also obtained in the limit of the vanishing local interaction, i.e., the discrete solitons may be supported solely by the DD interaction, which is relevant to the


experiment [@experim1]. In other words, the attractive nonlocal DD nonlinearity is by itself sufficient for the formation of trapped localized modes in the 2D lattices.

Solitons generated by the attractive isotropic DD interaction
-------------------------------------------------------------

In the case of the competition between the repulsive contact and attractive isotropic DD interactions, all unstaggered fundamental solitons have a bell-like shape, which is a consequence of the nonlocality of the interaction which creates them. This feature is also similar to what was found in the 1D counterpart of the present models [gpe]{}.

The $P\left( \mu \right) $ curves for the on-site, hybrid and inter-site unstaggered solitons in the present case are much closer to each other than it was in the case of the attractive contact interaction, see Fig. [fig12]{}. On the other hand, numerical computations demonstrateand dynamics of fundamental discrete solitons in two versions of the model, which are based, respectively, on the ordinary discrete form of the GPE (Gross-Pitaevskii equation) with the cubic nonlinearity, or the 2D discrete NPSE (nonpolynomial Schrödinger equation), both including nonlocal DD (dipole-dipole) interactions. Fundamental localized modes studied in this work are counterparts of solitons existing in the semi-infinite gap, in terms of the continuum limit of the discrete models. Only the situations with *competing* local and nonlocal interactions (attractive/repulsive, or vice versa) appear to be interesting. We have shown close similarity in the behavior of the fundamental unstaggered solitons in the discrete models of both the GPE and NPSE types in these cases.

The presence of the repulsive isotropic DD interaction competing with the local attraction extends the


245302 (2008).

J. Gómez-Gardeñes, B. A. Malomed, L. M. Floría, and A. R. Bishop, Phys. Rev. E **73**, 036608 (2006); *ibid*. **74**, 036607 (2006).

N. G. Vakhitov and A. A. Kolokolov, Izv. Vyssh. Uchebn. Zaved., Radiofiz. **16**, 10120 (1973) \[in Russian; English translation: Radiophys. Quantum Electron. **16**, 783 (1973)\].

Y. Sivan, B. Ilan, and G. Fibich, Phys. Rev. E **78**, 046602 (2008).

P. G. Kevrekidis, D. J. Frantzeskakis, R. Carretero-González, B. A. Malomed, and A. R. Bishop, Phys. Rev. E **72**, 046613 (2005).

J. Cuevas, B. A. Malomed, and P. G. Kevrekidis, Phys. Rev. E **76**, 046608 (2007).

V. K. Mezentsev, S. L. Musher, I. V. Ryzhenkova, and S. K. Turitsyn, JETP Lett. **60**, 829 (1994).

L. P. Pitaevskii, Phys. Lett. A **221** 14 (1996).

Figures
=======

![Examples of different types of fundamental unstaggered solitons in the 2Dthe center of the soliton. With the increase of coupling constant $C$, the SFBs appear at a smaller strength of the DD interaction, $\Gamma $. []{data-label="fig7"}](slika7.eps){width="9cm"}

![An example of a strongly pinned on-site soliton, which remains frozen" (completely insensitive to perturbations) in the course of the evolution. Parameters are $C=2,\protect\mu =-7,\Gamma =1$, which implies the combination of the attractive contact and isotropic repulsive DD interactions. In this and all following figures the results are presented for the nonpolynomial model. The findings are qualitatively the same in the model with the cubic nonlinearity.[]{data-label="fig8"}](slika8.eps){width="7cm"}

![The result of the application of a small perturbation to an unstable on-site soliton, which exists in the presence of the attractive contact and repulsive isotropic DD interactions ($C=2$, $\protect\mu =0.89$, $\Gamma
=0.1$). The soliton evolves into a persistent


toxin. The control mice received CFA containing no MOG peptide. This protocol leads to robust induction of clinical EAE on days 12--14 following immunization \[[@CR31], [@CR32]\]. The animals were monitored daily for clinical signs and scored as follows: 0---no symptoms, 1---flaccid tail, 2---paresis of hind limbs, 3---paralysis of hind limbs, 4---quadriplegia, and 5---death. The control and EAE mice were euthanized at different time points of disease, including 0, 4, 7, 14, 21, and 35 days. Most histological studies were performed on tissue obtained at the 21-day time point, corresponding to the acute symptomatic stage of disease.

Immunohistochemistry and antibodies {#Sec5}
-----------------------------------

Immunohistochemistry was performed on 10-μm frozen sections of cold phosphate buffer saline (PBS)-perfused tissues as described previously \[[@CR33]\]. Antibodies reactive for the following antigens were used in this study: rat monoclonalsstatins, cholesterol-lowering drugs that exert potent vasculo-protective and anti-inflammatory effects \[[@CR47]--[@CR49]\], are strong inducers of β4 integrin gene expression in endothelial cells. This was first demonstrated in a microarray study of human umbilical vein endothelial cells (HUVECs), in which from a panel of more than 6000 candidate genes, β4 integrin stood out as being the gene which showed the greatest (30-fold) increase following treatment with atorvastatin or pitavastatin \[[@CR50]\]. Since this time, other studies have confirmed this finding \[[@CR51], [@CR52]\] and also shown that statins prevent breakdown of cerebrovascular basal lamina proteins in ischemic stroke, consistent with a protective role in preserving BBB integrity \[[@CR53]\]. As the beneficial anti-inflammatory effects of statins are well proven \[[@CR47]--[@CR49]\], as well as their ability to suppress EAE progression \[[@CR54]--[@CR56]\], it is


tempting to speculate that some of this protection may be in part due to enhanced endothelial β4 integrin expression. In subsequent experiments, we will test this hypothesis by treating mice with atorvastatin to stimulate endothelial β4 integrin expression on cerebral blood vessels and compare the anti-inflammatory effects of atorvastatin in β4-EC-KO mice and WT littermates. If our prediction is correct, a significant part of the protection conferred by atorvastatin will be lost in β4-EC-KO mice. In a more direct approach, we also plan to generate a novel transgenic mouse strain in which β4 integrin is specifically over-expressed in endothelial cells and evaluate whether this strain is protected against EAE.

Conclusions {#Sec19}
===========

The goal of this study was to examine the contribution of endothelial α6β4 integrin to BBB integrity in neuroinflammatoryThere are numerous ways of securing an electrical connector to a circuit board or some other panel. For example, the connector may be provided with mounting flanges having bores that align with corresponding apertures on the circuit board. Fasteners can be extended through the bore and the board aperture to secure the connector thereto.
In other arrangements, such as disclosed in U.S. Pat. No. 5,145,407, a holding device is inserted through an opening in a component and has resilient legs for engaging the circuit board and securing the circuit board to the component. The mounting device includes one portion having a latch extending angularly from the plane of the mounting device. Further, the mounting device has barbs for securing the mounting device with the component. The mounting device also


of the hAECs on the immune response post stroke. Assessments will be made before hAEC administration, 1 h after hAEC infusion, and at 24 h, 3 days, and 1 week. Venepuncture will be performed using EDTA tubes at the time of enrollment and transported to the laboratory. We will measure the following: Lymphocytes: circulating T lymphocytes (CD4^+^, CD8^+^), CD56^+^ natural killer cells, CD19^+^ B cells, and T regulatory cells.Key cytokines and markers of inflammation: IFNγ, TNFα, IL-10, IL-17, IL-6, high-sensitivity C-reactive protein.BBB integrity: MMP-9 ([@B9]).Immunogenicity: HLA typing of hAEC and recipient.

Results {#S3}
=======

The expected outcome from Aim 1 is the MTD to inform the dose to be used in a Phase 2 trial. A smaller vasogenic edema volume, a decrement in infarct expansion, and a decrement in fractional anisotropy volume with dose escalation willECR as these therapies would confound the effect of hAECs ([@B8]). Apart from allogenic multipotent adult progenitor cells, hAEC is the only other stem cell tested at present in the first 48 h ([@B1], [@B7]). This therapy is attractive as hAECs are readily sourced from healthy term placentae, typically, for logistical ease, after elective cesarean section. There are about 45,000 term elective cesarean section births in Australia alone each year, after which the placenta is discarded. Each term placenta can provide 200--300 million hAECs, sufficient for one stroke patient (70--80 kg) at a dose of 4 million cells per kg. At higher cell doses, pooled cells from two to three placentae would be required for each adult patient. Unlike other forms of stem cell therapy, such as immortalized human


Laser gun fired from US Navy ship Published duration 11 April 2011

media caption A high-energy laser (HEL) fired from a US warship off the California coast has ignited a nearby boat. Video courtesy of the US Office of Naval Research.

The US Navy has fired a laser gun from one of its ships for the first time.

Researchers used the high-energy laser (HEL) to disable a boat by setting fire to its engines off the coast of California.

Similar systems had previously been tested on land, but moist sea air presented an extra challenge as it reduces a beam's power.

The navy said that ship-borne lasers could eventually be used to protect vessels from small attack boats.

The US military has been experimenting with laser weapons since the 1970s.

Early systems used large, chemical-basedElectric Concrete Could Help Melt Snow

Every winter, no matter how many snowplows are there, we still get snowed in at least once; but what if a new electric concrete could help melt snow?

Winter icy problems

It seems that each winter, especially if it’s a rough one, although snowplows roam the streets, cleaning them up of snow, there are still people who have trouble with snow, and even more people who have trouble with ice. The issue is that although snow is mostly removed, the roads can become icy as the chemicals and salt used for melting the ice, don’t always work as well as they should.

Besides, all of these snow “interventions”, the machines and whatever they spread on the roads are quite expensive and require a lot of workforce


gray lines indicate the isodepth contours of the upper boundary of the Pacific plate 30 with a 10 km interval. The gray contours and gray star in the upper left inset indicate the total slip distribution of the 2011 Tohoku earthquake^[@CR41]^ and its epicenter, respectively (contour interval of 4.3 m). This figure was rendered by Generic Mapping Tools (GMT)^[@CR42]^ 4.5.14.

In this study, we estimated the source process of this earthquake by using a joint source inversion with near-source waveforms and geodetic data (see "[Methods](#Sec5){ref-type="sec"}" section). The source-inversion analysis revealed large slips (\> 0.5 m) encompassing the epicenter at depths of 20--35 km with a maximum slip of 1.0 m, and their spatial extent was approximately 50 km × 60 km (Fig. [1](#Fig1){ref-type="fig"}).

Slow earthquakes actively occurred in the area surrounding the source region of the 2011 off Iwate earthquake (seeaseismic slip on the plate interface^[@CR5]--[@CR7]^, these results suggest that afterslip occurred just after the 1989 and 2011 events and that these afterslip triggered numerous aftershocks on the updip side of the coseismic ruptures. The similarity between the aftershock activity of the 1960 event and that of the other two events implies that an aseismic slip transient also occurred immediately after the 1960 event in the same area.

In area A, many earthquake swarms containing repeaters sporadically occurred outside the postseismic periods of the three large interplate events. Bursts of repeaters and earthquake swarms were detected in 1991, 1992, 1996, 2008, 2015, and 2016 during the periods of 1999--2010 and 2014--2016^[@CR5]^. Moreover, Kawasaki et al.^[@CR15]^ suggested the occurrence of an "ultraslow earthquake" in this area in 1992; the event


foreshock activities occurred in the active area of earthquake swarms containing repeaters (area Y), which is located updip of the main coseismic rupture area. Based on the history of repeaters and earthquake swarms, Nishikawa et al.^[@CR7]^ suggested the recurrence of aseismic slip transients in this area and pointed out that the aseismic slip transients that preceded the 1982 and 2008 *M*7-class events had larger seismic moments than the other transients. Moreover, the aftershocks of the 1982 and 2008 events occurred mainly in area Y and the foreshocks and aftershocks of the 1982, 2008, and 2011 events occurred in this common area (area Y), but the coseismic rupture extent of the 2011 event does not overlap with those of the other events.Figure 4Map view of the total slip distributionearthquake swarms containing repeaters off the Ibaraki coast covers the period from January 1991 to December 2010. In the catalogs, earthquake swarms are classified into "background swarms", where the first event is a background event, and "aftershock swarms", where the first event is an aftershock of a preceding earthquake. Nishikawa et al.^[@CR5]^ considered a background swarm to be a typical earthquake swarm, while they considered an aftershock swarm to be an anomalously intensive aftershock sequence that does not obey the Omori-Utsu law^[@CR39]^. This classification was disregarded in this study because it occasionally results in an obvious misclassification. For example, a swarm of seven *M*~JMA~ ≥ 6 interplate earthquakes accompanying the 1992 off Sanriku ultraslow earthquake^[@CR15]^, which was a typical earthquake swarm^[@CR13]^, was falsely classified as an aftershock swarm in the


The way TEC does business - Philip Turner

THE WAY TEC DOES BUSINESS

LET THE BUYER BEWARE!

The Reverend Dr. Philip Turner

The meeting of the Standing Committee of the Anglican Consultative Council (hereafter the Standing Committee) has just finished its deliberations. It was reported in The Standing Committee Daily Bulletin that Dato’ Stanley Isaacs had proposed, “The Episcopal Church (hereafter TEC) be separated from the Communion.” This proposal was rejected because it was believed, “Separation would inhibit dialogue on this and other issues among Communion Provinces.”

This brief notice is yet another signal that the Anglican Communion stands in unparalleled danger. The way in which TEC does business poses a serious threat to the evangelical and catholic identity of our Communion. I write to point out the nature of that threat andand an act of solidarity with those who are oppressed.

What were the consequences of breaking the rules? There was an attempt to bring the bishops to trial, but it failed despite committee advice to the contrary. The House of Bishops did decry the action of their colleagues and went on to pass a motion of censure; but since the bishops were all retired, the motion was of little effect. It was of so little effect that the following year Bishop George Barrett, yet another retired bishop, ordained four more women to the priesthood. Once again, no meaningful consequences followed. On their part, the women involved said that they consented to this action because to wait for another General Convention was to affirm in principle the concept that discrimination


discipline. A new way of effecting change had been established. If the constitutional and canonical processes do not go your way, act anyway, deny the applicability of consequences, and then call for conversation.

The same pattern appeared again shortly after the struggle over women’s ordination when the issue of ordaining people engaged in same gender sexual relations arose. In 1977 Bishop Paul Moore of the Episcopal Diocese of New York ordained a professed and sexually active lesbian to the priesthood. In response, the bishops did no more than express “disapproval.” The next General Convention passed a resolution saying, “It is not appropriate for this Church to ordain a practicing homosexual or any person who is engaged in heterosexual relations outside marriage.”

It appeared that the General Convention had spoken definitivelyon this matter, but some 20 bishops dissented, citing wording in the resolution that might be taken to meanthat the resolution was only “recommendary” and not “prescriptive.” Recommendation was most certainly not the intent of the General Convention! Nonetheless, the 20 bishops found an unintended loophole, claimed the prophet’s mantle and stated that they would not implement the resolution in their dioceses.

In 1989, 1990, and 1991 the dioceses of Washington DC and Newark ordained men involved in same gender relations. The justification for these actions was that new experience and knowledge make the ordination of gay people a “justice issue” that must be furthered by a “prophetic” episcopate. This time, one of the offending bishops, Walter Righter of Newark, was brought to trial; but he was acquitted--not on


consecrated a partnered lesbian as Suffragan Bishop of the Diocese of Los Angeles. Its General Convention hasalso called for the preparation of liturgies for the blessing of gay unions. When questioned about these actions, one TEC bishop responded that things had changed and The Episcopal Church had “moved on.” Now, having renounced their agreement, TEC’s leaders are appealing for dialogue, and the ACC has received a significant grant from an American source to promote the Continuing Indaba Project.

It is this observation that brings me back to the starting point of this essay. The Standing Committee has apparently acceded to TEC’s way of doing business. Though TEC has taken actions contrary to established Anglican teaching and against the counsel of all four Instruments of Communion, no “consequences” appear toIf this is your first visit, be sure to
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Historical Mystery Tour (608)

Natu, Xatu...Mysterious Forest!

Still in Twinleaf for the Twinleaf Festival, Ash & Co. bump into Barry and Barry & Ash soon begin a battle. Not long after that however, they discover a Xatu whom leads them to a circus. When they get there, Ash, Dawn & Barry soon find themselves shrunk down to tiny sizes. Having to tackle with a bigger world and evading the various Pokémon, they face a massive tasks to work out how to be back to normal


scene there were a flock of Spearows chasing Pikachu and Ash? Forgot to mention that it was also raining! Talk about a deja vu. Wait, I didn't see Ash and Pikachu reminiscence that event. Must have forgotten about that.

2) It's Island of the Giant Pokemon all over again, only this time, it's the real deal!

Now with that settled, I see James is a master of Goldeen catching whereas that one guy reminded me of another character from the series itself, but who? Seeing Barry's dad was a short heartwarming moment and he reminds me of another particular anime character from a sci fi show. I don't get what is so creepy about him. I sort of have eyes like that myself, but I don't wear a trench coat.

1.to respond to any situation. The Government will communicate information as appropriate. The people are asked to stay tuned to information from the Government and behave in a calm manner.

Q&As

(Abridged)

REPORTER: North Korea has strongly opposed the recently announced deployment of the Terminal High Altitude Area Defense (THAAD) missile defense system to U.S. Forces stationed in the Republic of Korea (ROK) and has warned against physical responses that seek to contain it. Do you think that this missile launch is related to the recent announcement about THAAD deployment?

CHIEF CABINET SECRETARY SUGA: In any event, the Government is currently at the stage of collecting and analyzing information in cooperation with the United States and the ROK.

REPORTER: There are press reports quoting ROK government officials as stating that North Korea’s actions


compost, which is primarily dependent upon the size of the animal. Secondary factors include the type of bulking agent, initial moisture content, and the temperature achieved in the pile. Table 2 provides some guidelines to estimate days required for the primary cycle and when to turn the pile to begin the secondary cycle, using mortality weight as a guide.

When the second phase is complete, the compost can be used as a fertilizer source or blended with bulking agent to begin a new compost pile. In addition to reducing the amount of new bulking agent required, the recycled product helps “jump start” the next pile by inoculating it with actively growing microorganisms. No more than 50% recycled compost should be used. Higher levels may result in carbon deficiency andneed to look in the mirror and see how better can be achieved.

This will likely mean more change. In fact, it’s already started. Ettore Messina has left after his lone season as an assistant coach/consultant to Mike Brown, heading back to Europe to coach CSKA Moscow. Quinn Snyder is still in house but is one of the final 3 candidates to land the head coaching job with the Charlotte Bobcats.

Beyond the coaches though, there will surely be changes on the roster. Gasol’s name will be floated heavily (after all, he was already traded once last pre-season). One can only assume Andrew Bynum’s name will also come up as a potential piece to be moved for a player (or players) of better quality and/or fit. Free agency will be


been as good as OKC if they had hired Shaw, and kept the Triangle, Odom, and Fisher, and the draft picks, either. Practice time and continuity can only take you so far. For those who are skeptical about that, look at the Memphis Grizzlies, who, with HCA, lost to a Clippers team that had had massive off-season and in-season personnel changes. Continuity helped some teams this year, but as Phil always said, it comes down to talent.

Had the Paul trade gone through…well, we will never know, in part because Paul might have lead to Howard (recall that there Paul + Howard rumors right after the lockout ended and Dan Gilbert said very specifically in the email that he wanted the deal blocked in part because he thought itthey talk about Brown and Buss, respectively. But the “in the Lakers we trust” meme simply doesn’t apply here. Too many changes have been made, from the top down.

But, if someone is promoting various forms of “blow it up”, they better be ready to deal with the ups and downs that come with building a contender back up from the rubble
—

I agree with this, and would add that there is no guarantee that a contrender emerges from the “rubble.” And the actual mechanics of “blowing it up” are not that simple in any case, given the structure of the league, the CBA, and the Lakers’ limited trade assets.

As to the first point, there is truth in that, but that also goes back to payroll and the ages of


score, score so his value grows (and the agent makes more money)?

IMO and it may only be mine, but what makes players like Kobe (great) and Westbrook (good) is their stubborness in thinking that they can perform better than everyone else on the floor. Sometimes it works, but most of the time it doesn’t. Kobe taking over causes our bigs to stand and watch. We have an older team so our players don’t cut or flash to the basket when Kobe turns and backs his player down. When they see him dribble to death or just stare at the clock, they do nothing.

As a result, we have a mis-matched team. We have four players Sessions, Barnes, Hill, McRoberts who would love to get up and down the court.the OKC crowd, it seems like 70% of them are middle-aged or older. Amazing how much noise they make for old people.

With all due respect to Michael Jordan (the best prime player of all time until now)… There has never been a player playing as well is LeBron James has this year. If all the pkayers that have ever played… Played today (completley not fair to former players) nobody would be as good as LeBron.

i say if we cant make changes with our starting lineup because of our stiff salary cap, we fix our bench and be good with it. our main problem is when our bench mob goes to play, they play softball with no heart. we need a reliable wing man or a point guard that


with Wade over Westbrook, they are just tougher and will wear down the Thunder. Bosh is a better player than Ibaka. Miami in 6.

Magic Phil-Westbrook rarely passes the ball late in the shot clock the longer he bounces the more apt he is to take the shot himself. He did this the first 4 possessions of the game and no one said anything to him. Durant took his mouth piece out of his mouth several times and looked like he wanted to say something.

Coach Brooks exhorted the team to pass the ball in the first half when OKC repeatedly looked for the knockout punch in the first few possessions of the game. It’s bothersome that OKC feels confident that no matter the score they’re going to come roaring[Primary cholangiocarcinoma associated with Caroli disease].
A 68 years old male presented with right hypochondrium abdominal pain and jaundice with no other clinical finding. CAT Scan and Ultrasonography showed right lobe bile duct dilatation. Magnetic Resonance Cholangiopancreatography gave an outstanding vision of a restricted right lobe bile duct dilatation associated to choledocholithiasis. A right hepatectomy and bile duct exploration were performed. The histopathological study disclosed a Caroli disease associated to a primary cholangiocarcinoma. Caroli disease is a congenital disorder characterized by intrahepatic cystic bile duct dilatation with a high risk association with cholangiocarcinoma.


topic Re: Samsung note 8 in Note8https://us.community.samsung.com/t5/Note8/Samsung-note-8/m-p/1169661#M16875

Hi there!

Unfortunately the andriod 10 update will not be coming to the note 8. I hope this helps
Thu, 26 Mar 2020 21:40:35 GMTAvhart2020-03-26T21:40:35ZSamsung note 8https://us.community.samsung.com/t5/Note8/Samsung-note-8/m-p/1169537#M16866

When will the Samsung galaxy note 8 recieve the android 10 one ui 2 update, if at all? Thank you.
Thu, 26 Mar 2020 20:43:25 GMThttps://us.community.samsung.com/t5/Note8/Samsung-note-8/m-p/1169537#M16866CDALLEN2862020-03-26T20:43:25ZRe: Samsung note 8https://us.community.samsung.com/t5/Note8/Samsung-note-8/m-p/1169549#M16867

Hello

 ,

Updates are carrier specific, so it all depends on your mobile carrier. Also it depends on the age of the device.
Thu, 26 Mar 2020 20:49:34 GMThttps://us.community.samsung.com/t5/Note8/Samsung-note-8/m-p/1169549#M16867derrickhenry052020-03-26T20:49:34ZRe: Samsung note 8https://us.community.samsung.com/t5/Note8/Samsung-note-8/m-p/1169551#M16868

Hi

Unfortounuly the note 8 will not receive the update its the 9 series and up.
Thu, 26 Mar 2020 20:50:19 GMThttps://us.community.samsung.com/t5/Note8/Samsung-note-8/m-p/1169551#M16868ClarenceC12020-03-26T20:50:19ZRe: Samsung note 8https://us.community.samsung.com/t5/Note8/Samsung-note-8/m-p/1169594#M16872

Sorry, I have the note 8 also and unfortunately we will not be receiving the update but[Treatment of proximal ulna and olecranon fractures by reconstruction plate combined with tension band wiring].
OBJECTIVE To review the efficacy of reconstruction plate combined with tension band wiring for treating proximal ulna and olecranon fractures. Between November 2004 and September 2009, 10 patients with proximal ulna and olecranon fractures were treated by reconstruction plate combined with tension band wiring. There were 6 males and 4 females with an average age of 45.3 years (range, 21-75 years). Five fractures were caused by traffic accident, 2 by falling from height, 2 by tumbling, and 1 by a machine strangulation. The locations were the left side and the right side in 5 cases respectively. One case was open fracture (Gustilo II) and the other 9 were closed fractures. Olecranon fractures included 4


cases of traverse fractures and 6 cases of comminuted fractures, and proximal ulna fractures included 6 cases of comminuted fractures and 4 cases of oblique fractures. The combined fractures included 6 radial head fractures, 4 coronoid process fractures, 2 proximal humerus fractures, and 3 scapula fractures; other injury included 1 elbow dislocation and 1 shoulder dislocation. Two patients had secondary operation; the other 8 patients received the primary operations and the time from injury to operation varied from 7 days to 20 days, with an average of 11 days. One case had infection at the incision 1 week after operation, and recovered after 2 months of antibiotics and debridement; incisions healed by first intention in other 9 patients. All patients were followed up 12-64 months (mean, 40.5 months).material to be configured in the elongate, rolled configuration.
A significant advantage of the invention relates to the ease of which the blind may be set-up and taken down. Also, the blind is lightweight and is adaptable to a variety of terrain conditions and set-up orientations. The blind also offers a rigid set-up which avoids the need for guy ropes and stakes and the horizontal members provide a gun or camera rest.


ended up using sortValue to do specific sorting base on value. In my case I used parseFloat with the string value.
var grid = new Backgrid.Grid({
collection: collection,
columns: [
 {
   name: "cost",
   label: "Cost",
   cell: "number",
   sortValue: function(model) {
     return parseFloat(model.get("cost"));
 },
 formatter: currencyFormater
 sortable: true
 },
 …
]});

he told me is a flute. People from my Mifflintown years will bust a gut because they know how much I sucked at playing the flute. BUT despite my suckiness at being a flautist, I did it for, let me see, oh, five years. Anyway, the shakuhachi isn't the kind of flute you're thinking of. It looks more like a recorder, and it's used for meditation. It's fucking hard as fuck to play. I tried for an hour. My cheeks hurt. But another zen master dude said that I had a rare quality for a beginner to play such clear, strong notes with such purpose. Rock on! So there I was, in the training room, with zen master flute player, and this other dude who was practicing martial


UCLA, Ying Ming Tu. I shouted, "Hey, Tu-tu!" He turned, his mouth dropped open, and he ran to give us a hug. He also just happened to be with Angela, another friend from LA. I worked with Angela on her book, "Open," which talks about her work as a civil rights lawyer and her philosophies that have arisen out of that. She's also a Zen Buddhist priest.

Angela touched my hair and asked me why purple? I explained how I'm going to have chemo in a couple weeks and wanted to dye my hair a funky color before it fell out. I told her that I was just diagnosed with breast cancer. Her hand went to the exact place of the tumor without me telling her which breast orI haven't felt like that would work. But now, with this completely serendipitous encounter at the airport--at the moment when DH and I were coming, and Tu and Angela were leaving--I feel a sense of joy and encouragement and spiritual uplifting. Even DH, who's not really into thinking about meditating and such things, looked happy. It was a really special moment.

If you're not on this list--so sorry! I was wasted and all, that's my only excuse!

There was a lot of laughter and tears and drinking last night. I was so touched by all who showed up and also by those who couldn't make it but who emailed me their regrets. Here are some highlights--including the highlights in my hair! (Thanks especially to Jamie--who applied TWO bleach kits to


my hair yesterday, down the roots while somehow miraculously not burning my scalp; Jenn and Katie--mistresses of the dye; and Katie once again, for packing sausage, cheese, crackers, wine, and god knows what else in her purse, along with loads of latex gloves.) Jenn was the photographer extraordinaire for these shots.

Me and bleach expert, Jamie

Me with Paige and Joy enjoying the mixture of fumes from my head and the wine

Sausage, cheese, dates, and crackers spread out on my toilet

Emerging from my bathtub...

It's not what it looks like--Amy's just drying my hair while I'm drinking wine while straddling my toilet...honest!

Karrmen and Amy stylin', while Saya and Jordy look on.

All dressed up--and yes, I am wearing fur in the middle of July! That's cuz you can do that in Vancouver,some more. I want to make sure we're confident about what we're doing, cuz this ain't like buying a car or something, where we might not be satisfied with a term here or there. He's the hunter and gatherer--of information. Me? I have a boob that's hella angry with me.

Friday, July 20, 2007

Today was a downer. Not for any good reason. Today could have been like yesterday or the day before, but for some reason, I didn't seem to want to do anything but burrow in my bed.

I got an Air Cast today. When I had my bone scan done yesterday, the technician saw a stress fracture in my leg and asked me if I was a runner. I guess so, I said. So now I have this


crazy. This is limbo--only knowing so much, which is very little, and not being able to do anything but wait and wait and wait and wait.

I'm 31 years old. I've got two kids, and I've got a ton of shit to do. Last thing I need is cancer. It's the last thing anyone needs.

My brother-in-law died of lung cancer on July 7, 2007--five days before my diagnosis. His situation, of course, was way more serious--that is, as far as I know.

I mean, it's not like I'm, "Thank GOD I have breast cancer!" But it's like, "Thank god I don't have some type of other cancer that's worse."

About Me

I grew up in rural Pennsylvania with my Vietnamese mom and Pennsylvania Dutch dad, and went to university in Boston, LosNorway Thread

in an attempt to be less sarcastic.

Medal chances:

Andreas Thorkildsen - chucking the javelin
Jaysuma Saidy Ndure - special import from Gambia
Alexander Dale Oen - first swimmer from Norway since the Black Death
women's football team - led by the inimitable Solveig Gulbrandsen
women's handball team - funded by Danish milk
race walkers - er, yeah...
Olaf Tufte - who trains 1500 hours a year - possibly the Norwegian athlete who trains the most - along with running a farm
skeet shooting (I think)
Gunn Rita Dahle FlesjŚ - most winning athlete in women's mountainbike, though has just had a huge injury.

Founder of ESAS - Edgar Schiferli, the best associate bowler
A follower of the schools of Machiavelli, Bentham, Locke, Hobbes, Sutcliffe, Bradman, Lindwall, Miller, Hassett and Benaud
Member of JMAS, DMAS, FRAS and RTDAS

when you're winning,


well, Beardsley said; pike also are hitting jig-and-minnow combos. Look for crappies in the cabbage early and late in the day and along the outside edge of deeper cabbage the rest of the day, Beardsley said. Small jigs and plastics are working well, and most of the bigger crappies have been right near the bottom. Bluegill action is good in areas with deep cabbage, and bass fishing remains excellent all day long, Beardsley said. For bass, try topwater baits early and late and Texas-rigged plastic worms during the day as the fish slide out to deep weed edges.

Leech Lake

Fishing has been stable during the recent stretch of more consistent weather, Jason Freed of Leisure Outdoor Adventures reports. For walleyes, trolling Shad Raps or similar crankbaits during the daythe prime factors of 524537.
13, 157, 257
List the prime factors of 240914.
2, 163, 739
What are the prime factors of 1820567?
7, 260081
List the prime factors of 3959308.
2, 989827
What are the prime factors of 7386399?
3, 820711
What are the prime factors of 753758?
2, 263, 1433
What are the prime factors of 462862?
2, 231431
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2, 604313
List the prime factors of 7507725.
3, 5, 100103
What are the prime factors of 3248866?
2, 811, 2003
List the prime factors of 22329352.
2, 37, 75437
List the prime factors of 5129167.
31, 165457
List the prime factors of 506458.
2, 253229
What are the prime factors of 349665?
3, 5, 23311
List the prime factors of 292642.
2, 7, 20903
List the prime factors of 2976052.
2, 571, 1303
What are the prime factors of 365010?
2, 3, 5, 23
What are the prime factors of 5455046?
2, 709,


possible to define an operator overload in a type extension. There is an F# language user voice item for this (with quite a lot of votes) and so this is something that might change in future versions of F# (I think it would be great addition that fits nicely with the F# design).
If you absolutely need something like this today, you can either create a lightweight wrapper for your type that adds the operators, or you can use a (somewhat scary) trick that lets you hide the standard operator with a new overloaded one. The following question has both examples: Global operator overloading in F#

definitive view as to the ontological status of the sensible qualities, Boyle recontextualizes the discussion of many of the central issues that pertain to the nature of the sensible qualities within the development of his corpuscular chemistry.26 The question, however remains: Do Boyle's speculations make a strong enough claim to the stability of an intrinsic nature proper to different particles to cause Spinoza concern? In his first letter to Boyle, Spinoza argues that it is not necessary to examine whether the demonstrations that Boyle offers to show that 'the tangible [or sensible] qualities depend only on motion, shape, and the remaining mechanical affections' are 'completely convincing' because 'he does not present these demonstrations as Mathematical' (Letter VI). Whatever speculative content there is to Boyle's understanding of the nature


of the sensible qualities, this comment indicates that Spinoza is not overly concerned by it, because he does not consider Boyle to have demonstrated this with any rigour, which is what Spinoza's reference to mathematics serves to indicate. So contrary to the above suggestion that this speculation on Boyle's part would contradict Spinoza's mechanism, Boyle's speculation about the stability of these qualities, or the non-disruptability of certain characteristic qualities at a chemical level, does not necessarily imply a difference in intrinsic nature between the particles exhibiting such qualitative stability. In fact, Spinoza's distinction between fluid, soft and hard bodies in the Lemmas of the second part of the Ethics would have provided support for such speculation.27 It is the very transitional nature of the corpuscular chemistry which BoyleLavoisier would designate the bifurcations and ruptures of analytic chemistry that are only retroactively reconnected with Boyle's corpuscular chemistry. It is only by virtue of this relation of bifurcation/rupture and retroactive reconnection that the proper names of Boyle and Lavoisier should be understood to be juxtaposed in relation to one another in the ramified time of science. A closer examination of the correspondence between Boyle and Spinoza is required in order to support the assessment of the distinction between their replies to one another as being characteristic of the distinction between science and philosophy. In Letter VI, Spinoza responds to Oldenburg giving his 'judgment of what [Boyle] has written (. . .), noting certain things which seem to [him] obscure, or 126 Paragraph inadequately demonstrated'. He begins by


done a further experiment that would have shown that: 'Spirit of Nitre The Difference Between Science and Philosophy 127 is not really Nitre and cannot be solidified or crystallized without the aid of the alkaline salt' (Letter VI). Without such an experiment, Spinoza considers the hypothesis of the homogeneity of nitre and its spirit, which he will introduce as an alternative explanation of the experiment, not to have been ruled out. Spinoza also claims that 'what the Distinguished Author says he observed with the aid of the scale (§9)', does 'nothing to confirm his conclusion' (Letter VI). In §9 of the Essays, Boyle reports that he weighed the spirit of nitre necessary to fully dissolve the fixed nitre and compared this with the weight lost by the nitrewhen it was separated from its spirit, and found that 'the weights were nearly, but not quite equal'.32 Spinoza maintains that Boyle's quantitative check did not support his case. He argues that Boyle should have at least tried to show that, in the decomposition of nitre, a given quantity of nitre always produces that same quantity of fixed nitre or that the quantity of fixed salt obtained was always proportional to the amount of nitre required to produce it. While Spinoza's reasoning is quite justified in this criticism, it should be noted that he too fails to satisfy these requirements in his own experiment, thought he does acknowledge that he does not have the means to do so. Despite this, he incorrectly claims that, if this quantitative check


number of commentators are also critical of these comments by Spinoza and of what they consider to be Spinoza's understanding of experiments, that is, that he relegates them to the imagination because they deal with the senses, and that he therefore considers them to have no bearing on the principles of reason. This understanding belies the constitutive nature of the imagination in Spinoza's epistemology, which he characterizes as the first kind of knowledge, and its role in the development of reason, or the second kind of knowledge. When, in Letter VI, Spinoza states that fluidity and solidity belong to the class of notions determined by the use of the senses and therefore belong to the imagination, this is not to relegate these notions to some ineffective epistemological categoryspeculations about corpuscular chemistry. He did not want to give just mechanical explanations, but to distinguish properly chemical from physical explanations. Despite the criticisms that each makes of the other's experiments, these criticisms are made from within the same mechanical view of the world. This requires the tacit acceptance by both men of a certain number of general presuppositions associated with the problematic of deploying the mechanical principles in relation to what was in the process of being established as their respective disciplines. All of this occurs prior to the expression of particular points of disagreement in the correspondence. The difference between Boyle and Spinoza's respective accounts of the experiment can therefore be understood according to the different way that they each respond to the particular problematic about


that Boyle was attempting to construct quite seriously, though in the correspondence he made the mistake of putting forward a simplistic image of it, one that had no scientific value for Boyle. The solutions that Spinoza attempted but was unable to offer to the problem of the redintegration of nitre were philosophical solutions, 136 Paragraph whereas those that were in nascent form in Boyle's speculations were indeed scientific solutions, and their value to the development of analytic chemistry has been retroactively vindicated. NOTES 1 Robert Boyle, Certain Physiological Essays, written at distant times, and on several occasions (London, Herrington, 1661). The book contained 'A physicochymical essay, containing an experiment, with some considerations touching the differing parts and redintegration of salt-petre', and was published in Latin the same yearas Tentamina quaedam physiologica, diversis temporibus et occasionibus conscripta (1661). It is the Latin edition that Spinoza would have read. 2 Gilles Deleuze and Félix Guattari, What Is Philosophy?, translated by Graham Burchill and Hugh Tomlinson (London, Verso, 1994). Henceforth WIP. 3 See Henri Daudin, 'Spinoza et la science expérimentale, sa discussion de l'expérience de Boyle', Revue d'Histoire des Sciences 2 (1948), 179–90. See also A.R. Hall and Marie Boas Hall, 'Philosophy and natural philosophy, Boyle and Spinoza', in Mélanges Alexandre Koyré, vol. 2 (Paris, Hermann, 1964). 4 For a defence of Spinoza from the point of view of the inconsistent ontological status of Boyle's elements of matter, see Christopher Lewis, 'Baruch Spinoza. A Critic of Robert Boyle, On Matter', Dialogue. Journal of Phi Sigma Tau 27:1 (1984),


Q:

AWS AppSync IAM Authorization with Cognito Federated Identities

I am using AWS AppSync, and logging in users with Cognito Federated Identities.
I'm hoping to have unauthenticated users have access to certain endpoints, while authenticated users will have access to other endpoints.
I have configured IAM Roles for each of the aforementioned, using e.g.             "Resource": [ "Region:Account:apis/AppSyncName/types/Mutation/fields/XXX”]
My question is — how can I, using Cognito Federated Identities, get credentials to send through the AppSync Client.
My configuration for AppSync:
const client = new AWSAppSyncClient({
  url: config.AppSync.ENDPOINT,
  region: config.AppSync.REGION,
  auth: {
    type: AUTH_TYPE.AWS_IAM,
    credentials: () => ReturnCredentials()
  }
});

My Login Function
login(username, password) {
    const user = new CognitoUser({ Username: username,Auth module from Amplify inside the AppSync client constructor like so:
const client = new AWSAppSyncClient({
    url: AppSync.graphqlEndpoint,
    region: AppSync.region,
    auth: {
        credentials: () => Auth.currentCredentials(),
    },
});

From there you pass the client object to the Apollo GraphQL Provider:
const WithProvider = () => (
    <ApolloProvider client={client}>
        <Rehydrated>
            <App />
        </Rehydrated>
    </ApolloProvider>
);

Now you can start making standard GraphQL calls to AWS AppSync using Apollo. The data will automatically be persisted offline but if you'd like to do offline mutations you'll need


back to an ingress node where the packet enters the network. The ingress node recomputes and establishes an alternative virtual circuit as soon as possible. However, given that the signaling time required to propagate a signal for a round-trip across the continental United States is about 75 milliseconds, this approach is too slow to be compatible with SONET's restoration time of 50 milliseconds.
In a second conventional approach, a master server monitors the network and pre-establishes alternative virtual circuits. The master server is notified of a failure and directs traffic to an alternative virtual circuit. However, the signaling between the master server and the failed elements still causes delay. Furthermore, if the failed node or link carries multiple virtual circuits, multiple signaling can create a peak in both theNewspaper editorial: Poverty

The client is a Western newspaper doing a feature on poverty. They seek a suitable B&W image to illustrate the story. Since the article is not about third-world poverty, they do not want images of mud huts, hand plowing, aid packages, etc., but of "civilized" poverty. The image must be bold and grab the attention of the readers, drawing them to the story. People in the image must not be recognizable.

Show full rules

Announced:

Wednesday, 18th May, 2011 (GMT)

Submissions:

Wednesday, 25th May, 2011 –
Tuesday, 31st May, 2011
(GMT)

Voting:

Wednesday, 1st June, 2011 –
Tuesday, 7th June, 2011
(GMT)

Processing rules:

No borders or watermarks.

B&W images only, no toning or selective color.

Capture date rules:

No restrictions.

Additional rules:

Issues and questions are addressed in the "Challenges and Galleries" forum.


time to see what the little boys were doing.

Gernot: Later, we started DJing together in a club. We had a little weekly club night on a Wednesday in Berlin. [We played] everything, but no techno. We tried to make something different. We both grew up with techno, we are techno kids, we went every week to the Tresor club. We were socialized with techno and later on we tried to find something different.

Sebastian: I remember we played jungle with high-pitched vocals.

How would you describe your sound?

Sebastian: At the end of the day, we still can’t say how we sound. It depends. We’re telling stories to music. We are musicians and we are sitting every day in a studio and we are creating music. We are always searching forwhole club and the party was very excessive. Jimi Tenor was standing in the corner and he was pissed that the party was so good. He was living in New York at the time. He was there with Khan, and Khan said, “Yeah I want to stay here” but it was too much for Jimi and he had to leave. It was really hard clubbing. They couldn’t sell any cocktails because everyone had destroyed all the glasses by smashing them.

Are you still partying so hard?

Gernot: We try to keep our body and mind clear. We try to be not so wasted because we play two or three times per weekend. We don’t use [drugs]. We drink alcohol and smoke pot. I like the feeling of being awake for


two days without chemicals helping your body. I see it in a sporty way, like it’s a show of skills. Just have good food, good drinks, and then you can stay awake for seven days! Watch Charlie [Sebastian] and me, we are looking fantastic!

What is one band or artist that you both really like?

Gernot: Shellac, Steve Albini. He was born in Missoula, Montana. We wanted to go to Chicago and visit him but there was not enough time. Also we used to be big Aphex Twin fans. And we like rap, especially the stuff from New York, and the Bay Area, like E-40 and Keak the Sneak.

Tell me some crazy stories from your U.S. tours.

Gernot: New York is my favorite town in the U.S., but last time forReligious satellite TV show Miracle Hour 'risking lives' By Andy Dangerfield

BBC News, London Published duration 21 February 2013

TV shows made in London that encourage viewers to believe they are cured of life-threatening illnesses by prayer have been condemned by charities.

Charities criticised an episode of the Miracle Hour show, on Faith World TV, during which a diabetic caller was told he was "set free" from the disease.

"It is particularly dangerous and puts his life at risk," said African Health Policy Network head Francis Kaikumba.

UKWET, which produces the show, said it was "reviewing" its "new programmes".

The organisation, whose full name is the UK World Evangelical Trust, said: "We are now reviewing our new programmes to make sure our standards meet good practice."

Miracle Hour is filmed at Faith World TV's studio


beautiful built in BBQ Island w/fridge, seating for 3, exterior fireplace and a private SPA for your enjoyment! The beautiful fully fenced yard wraps around the property with a side gate entrance, new irrigation front, back & side, has lots of greenery, shade & fruit trees and some artificial turf in the side yard. Surround sound throughout house, patio & including 2nd garage. Electrical 220 set up in 2nd garage. New Reverse Osmosis & water installed 2018. Whole house has sunshades and plantation shutters. House exterior & fence painted 2017. We also have a Home warranty transferable thru 9/18/21. This house has too many upgrades to list and will not last long!! Come and see it today!

School Information

Description

Your home sweet home awaits your arrival! This home boasts lotsWhat is ETHWORLD? ETHWORLD is a game built on Ethereum that lets you own a completely unique blockchain representation of countries around the world. After purchasing a country, you'll start earning rent and the market price will automatically increase.


   The underlying dispute concerns a medical office building in
11   Los Angeles, California.   At the time Kwon and An met in 2001, An
12   was renting the building from a third party under a lease.   An’s
13   business ventures were not generating sufficient revenue to pay
14   all of his bills, including his rent.   Over time, Kwon lent An,
15   in aggregate, roughly $1 million in order to help An pay his
16   expenses.
17        Kwon later became concerned that An could not pay his rent
18   and might be evicted from the office building, which in turn
19   would prevent An from generating furtherbuilding.
 8        The state court entered judgment after trial denying Kwon
 9   any relief on his unlawful detainer complaint, apparently holding
10   that the issue of ownership prevented the court from granting
11   Kwon relief in a summary unlawful detainer proceeding.
12        At the time of commencement of the unlawful detainer
13   proceeding, the Ans already had filed their first chapter 7
14   bankruptcy case, but Kwon did not learn of the bankruptcy case
15   until sometime in early 2006, about the same time the 2005
16   bankruptcy case was closed.
17        An also filed in 2005, in the state court,


his medical corporation Woori Medical
 4   Center Corp., and his spouse Lauri for, among other things,
 5   possession and damages based on their alleged wrongful possession
 6   of the office building.   The state court litigation was subject
 7   to years of delay, which the state court generally attributed to
 8   An.   Eventually, a bench trial took place, after which the state
 9   court ruled in favor of Kwon.   According to the state court, An’s
10   testimony generally lacked credibility.   More specifically, the
11   state court found that An’s contention of an oral agreement
12   providing for co-ownership of the office building was false.  and not in dispute.       See In re Barboza, 545 F.3d
28   at 706; In re Su, 290 F.3d at 1144–46.      Therefore, we will focus

                                        9
 1   instead on the Ans’ arguments on appeal.
 2        Without citing any California authority, the Ans claim that
 3   Kwon’s ejectment cause of action sounded in contract rather than
 4   tort.   Therefore, the Ans reason, because the


7   ownership claim in order to wrongfully keep possession of the
 8   office building for as long as possible, all to Kwon’s detriment.
 9   We hold that the bankruptcy court’s finding regarding An’s
10   subjective state of mind was a reasonable inference drawn from
11   the evidence presented to the bankruptcy court at the time of the
12   trial.
13        An also identified as an issue on appeal the bankruptcy
14   court’s determination that An acted maliciously within the
15   meaning of § 523(a)(6).   But his opening appeal brief does not
16   contain any argument specifically and distinctly challenging this
17   determination.   Consequently, An has    Under the correct standard, conduct is considered malicious

                                     13
 1   for purposes of § 523(a)(6) if it is:   “(1) a wrongful act,
 2   (2) done intentionally, (3) which necessarily causes injury, and
 3   (4) is done without just cause or excuse.”    In re Jercich,
 4   238 F.3d at 1209.
 5        Here, the bankruptcy court did not make a specific finding
 6   as to each of the


package org.osmdroid.mapsforge;

import android.os.Build;

import org.mapsforge.core.model.Tile;
import org.mapsforge.map.layer.renderer.DirectRenderer;
import org.osmdroid.tileprovider.IRegisterReceiver;
import org.osmdroid.tileprovider.MapTileProviderArray;
import org.osmdroid.tileprovider.modules.IFilesystemCache;
import org.osmdroid.tileprovider.modules.MapTileFileArchiveProvider;
import org.osmdroid.tileprovider.modules.MapTileFilesystemProvider;
import org.osmdroid.tileprovider.modules.SqlTileWriter;
import org.osmdroid.tileprovider.modules.TileWriter;
import org.osmdroid.util.MapTileIndex;

/**
 * This lets you hook up multiple MapsForge files, it will render to the screen the first
 * image that's available.
 *
 * Adapted from code from here: https://github.com/MKergall/osmbonuspack, which is LGPL
 * http://www.salidasoftware.com/how-to-render-mapsforge-tiles-in-osmdroid/
 * @author Salida Software
 * Adapted from code found here : http://www.sieswerda.net/2012/08/15/upping-the-developer-friendliness/
 */
public class MapsForgeTileProvider extends MapTileProviderArray {
    IFilesystemCache tileWriter;
    /**
     *
     * @param pRegisterReceiver
     */
    public MapsForgeTileProvider(IRegisterReceiver pRegisterReceiver, MapsForgeTileSource pTileSource, IFilesystemCache cacheWriter) {
        super(pTileSource, pRegisterReceiver);

        final MapTileFilesystemProvider fileSystemProvider = new MapTileFilesystemProvider(
    is that CD38 may run an escape circuit leading to the production of adenosine. The generation of local anergy may be blocked by using anti-CD38 antibodies. Consequently, not only might CD38 be a prime target for mAb-mediated therapy, but its functional block may contribute to general improvement in cancer immunotherapy and outcomes.


First Round

Taiga Kamichatani

Position: Right Handed Pitcher

School: Toyo University

Birth date: 31/08/1996

Hometown: Kyoto

Analysis: Went 10-4 in his college career with a 2.23 ERA. In the Spring 2018 season he was awarded with best pitcher of the league. Has good control to hit the inner and the outside corners.Has good stamina and can throw at 151 KPH (93 MPH). Can pitch a cutter and a fork ball.

Second Round

Yukia Ito

Position: Infielder

School: Rissho University

Birth date: 30/08/1996

Hometown: Yokkaichi

Analysis: Although has small frame he can hit for power. Was awarded as Top Nine player in Big6 league in 2018.

Third Round

Shinichi Onuki

Position: Right Handed Pitcher

Team: Shin Nittetsu Sumikin Kashima

Birth date: 03/02/1994

Hometown: Yokohama

Analysis: Can throw at 148 KPH, has a decent splitter.

Fourth Round

Atsushi Katsuma

Position: Right Handed Pitcher

School: Nihon Daigaku Tsurugaoka High School

Birth date: 22/05/2000

Hometown: Komae

Analysis: Can throwup to 152 KPH, off speed pitches are curve ball, cutter and a slider. Sometimes has control issues and is not uncommon to see four balls thrown in a row.

Fifth Round

Kyosuke Mashiko

Position: Catcher

School: Seiran Taito High School

Birth date: 27/12/2000

Hometown: Utsunomiya

Analysis: Has a very strong arm and has been timed throwing from home to second in 1.72 seconds. Can hit for power.

Sixth Round

NaotoChino

Position: Infielder

Team: Niigata (BCL)

Birth date: 16/02/1999

Hometown: Sanjo

Analysis: He is very athletic. In the BC league he hit 11 home runs in 97 games and stole 30 bases.

Supplemental Round

Daita Miyagi

Position: Right Handed Pitcher

School: Shiga Gakuen High School

Birth date: 15/07/2000

Hometown: Kadena

Analysis: Can throw up to 141 KPH, off speed pitches are curve ball, slider and a change up.


substrate. Figure [2e](#Fig2){ref-type="fig"} presents the thickness map acquired from the boxed region (red) in Fig. [2d](#Fig2){ref-type="fig"}, calculated from the low-loss EELS spectrum imaging, where the relative thickness ranges from \~125 nm on the left-hand side to \~65 nm on the centre of the right-hand side.Figure 2(**a**) DF STEM image of a cross-section of sample 1, showing the FeRh thin film grown on the MgO substrate. (**b**) EELS chemical maps acquired from the box region in (**a**) displaying the elemental distribution of rhodium, iron and oxygen. (**c**) HR STEM image showing the localised structure of the epitaxially grown FeRh and its interface with the MgO substrate. (**d**) BF TEM image of the planar view of sample 1, with the SAED inset. (**e**) Thickness map of sample 1 calculated from the low-loss EEL spectrumnanostructure is consistent with the reduction of magnetostatic energy at this boundary. This is also consistent with the circumstances that a nanoscale magnetic cylinder will form a vortex if it is thick enough and has a large enough diameter^[@CR30]^. Micromagnetic modelling included in the SI (Fig. [S3](#MOESM1){ref-type="media"}) further reinforces the energetics of the domain structure in this system of AF/FM coexistence at this early stage of the magnetic transition. As the FeRh thin film is heated to 90 °C (Fig. [9b](#Fig9){ref-type="fig"}), the magnetic domain highlighted in Fig. [9a](#Fig9){ref-type="fig"} is observed to grow and additional small vortex structures are seen to nucleate at scattered positions (arrowed). Heating to 95 °C (Fig. [9c](#Fig9){ref-type="fig"}) induces further nucleation of vortex structures (arrowed) and their agglomeration into an intricate system of interacting magnetic strings. The DPC image of Fig. [9d](#Fig9){ref-type="fig"}


single second. I'll send someone down to give you a break about every four hours."

And with that, Jason was alone.

The dials moved slowly, but they never ventured outside the prescribed lines.

It was an enormous ship, yet it wasn't one of a kind. Japan had built one too. China was working on one as well, but theirs seemed plagued with problems. But as high as demand was for their product, the world only needed a few of them. Lava was a free resource, but it wasn't found everywhere. The Japanese model was capable of pumping the lava off the ocean floor, a feat their behemoth couldn't accomplish. But it pushed Japan's expenses through the roof and made their products nearly four times as expensive as what their behemoth couldthe water better, they were crudely mounted on giant hydraulic rams and were incapable of intricate shapes. The stem and stern needed hours or days of shaping and finishing with jackhammers and grinders before they looked normal. But it was still worth it.

He had served a year on one of the grinder docks where all he did was replace spent grinding wheels on massive motorized rails that turned rough squares into smooth and curved lines. It seemed like ultra-light concrete to him. The dust rarely floated, but jackhammered chunks bigger than a fist seemed to float forever and felt lighter than aluminum, nearly as light as Styrofoam.

And talk about strong. The few times he used a jackhammer to prep the insides, it seemed to cut more than chisel.


through Saturday and was taking classes at the community college, as she could afford them. She was busy. Her friends were here. Her life was here.

He was just visiting.

Perhaps they hit it off better in his mind than in hers.

His assignment would last for a year; he had time. This was early in any new relationship. But it wasn't really new.

It was weird knowing someone so well, but just recently meeting them in person.

He laid and stared at the ceiling.

"Don't push. Back off, you idiot." He put his hand over his eyes.

The door clicked, then opened as Gina came back in. "You slept through breakfast, Jason, those must be prescription-grade pills."

Sitting up, he looked to the door. She had two cups of coffee in a cardboard holder withleft me feeling groggy and hung over for a few hours every morning." He hungrily finished off the biscuit. "I'll trade vivid dreams for a hangover any day."

She read the back of the bottle. "Vivid, or trippy?"

He reached over her for one of the coffee cups, then sat facing her, as intimately as possible. "I don't really know for sure. I never had really vivid dreams before. It might be trippy," he chased that thought with a sip, "for all I know. It is found in the hippy vitamin section of the store."

She leaned away from him, but just slightly so her back rested against the headboard, "So, what's on the agenda today?"

"It's your island."

She turned the TV to the Weather channel. Showers by noon. "We could catch


the same thing most of the time, and she didn't take meddling kindly.

He suddenly had doubts about what he was even doing with her.

She was damaged. She came with baggage he might never be able to lift.

But the heart loves who it loves. And right now, that was her.

He hugged her a little closer. Just a few months ago, this would have been impossible. Just being comfortable with being touched on the hand was a major milestone for her.

It didn't seem possible to sail an island— why was he suddenly thinking about that? The mast alone would have to be as big as a hundred-story building— the dimensions of it all just seemed laughable. Yet, there was another side to physics taken to that extreme.

A dozen propellers seemedprotests came from global-warming advocates who claimed that the world was going to end because, "greenhouse gasses were WARMING the surface of the ocean TOO much!" As a ship intended for international waters, they could use whatever source of power they could afford, and neither had to ask for permission nor care about complaints. The company was even petitioning the UN, most likely for publicity reasons, for official country status for the island.

The thermal generators seemed to make an enormous amount of sense. Anyone who owned a mobile island would naturally keep moving it to chase the seventy-degree weather, all year round, which was perfect for just such a machine. Besides that, refueling with oil or anything like it would be insanely expensive and complicated to say the


he contemplated the road his words were starting to travel. "I just want normal, you know."

She exhaled toward the ceiling. "Normal is harder to find than everyone thinks."

There was only so much pressure he could put on her.

"If you go back home and the distance doesn't work out," she took another drag and held back a morning cough, "then it wasn't meant to be, I guess."

"Yeah, but, I mean for this to be. I really like you, Gina, and what's more, I'm fairly head over heels right now." He put his cigarette out. "I can't imagine being that far away from you again. It would be incredibly painful for me." But he was worried about the end of his contract. What he did, though important, could be doneever promised him regular work. He had dipped into his meager savings and now couldn't even afford a plane ticket home.

He walked down to the end of the street, stopping at the bus stop, and fished in the trash for the classifieds. Most seemed to require a car, but he continued to look. It was a catch 22. He needed a better job to afford a car to get a better job. Arghhh!

It was what it was.

An article about middle of A5 caught his eye.

Scientists had years ago discovered the 'jet stream' on the sun. It had long been known that the sun had cycles, every 11 to 22 years it seemed. But those cycles could last for hundreds of years, as was seen during the Little Ice


and bicycles for everyone, except politicians.

He stuffed some of the more promising job slips in his pocket and trashed the rest of the paper before walking home.

End of the world, or the end of a world worth living and the end of all modern conveniences. It was lose lose, lose lose.

If it bleeds, it leads. If it means the end of the world, it's on A5.

The problem, as he saw it, was that the debate was religious, not scientific. The CO2 side believed that salvation was only achievable if man repented for his sins. It required the same religious repentance as that of passing a rich man through the eye of a needle. The sun advocates, on the other religion, believed it was all out of their hands.ground and cleaned, and the square holes intended for the pistons had to be bored as well. In addition to dozens of other mounting holes.

Jackhammers were heavy and loud, but lucrative, and he was well used to working with them. As well as changing grinder heads on the power equipment that was everywhere around the docks. Ten hours a day, five days a week, rain or shine they worked. It was boring and dull, but it paid better than any job he had had thus far, and he had, sooner than any had thought, saved up enough for a car.

In this case, a four-year-old Yaris.

He pulled up in the parkinglot, popped the trunk, then got out his lunchbox and waved as his new car pulled away.

Gina's mom needed


especially while talking. "I don't know. I turned it off an hour or more ago. Kept fading in and out and, that gets a little distracting after a while."

She flipped it to AM and tuned in a late night broadcast from the west coast. "I thought you liked this guy?"

"I do, or, uh, I did. I think they were talking about ghosts and alien abductions tonight— not one of my favorites. I like listening to the crazy conspiracy theories and the weird NASA scientists."

She twisted the dial and brightened the lights on the sail as she peered out the window. "Seen any planes or other boats?"

"No, but I wasn't exactly trying to." He dimmed them back down and lowered the lights in the room. "Caught a little snippettheir spectrum. However, when a star like ours starts to go through an intense flaring period, like ours appears to be, its spectrum, when seen from a distance, shifts. It's brightness shifts, and to observers from outside our solar system, it appears to be a different class of star.

Since we've only been able to study the spectrums of other stars for the last century, we never observed a known star to shift like this. And when we did, we attributed the difference to human error, improved equipment, or closer orbits and such. We completely dismissed the idea of solar storms this big and this powerful as being common occurrences."

"So, what can we expect now?" George calmly asked.

"Well, the short answer is, we don't know. Nobody does. Everything is


turning it off. Going without vegetables wasn't pleasant, but it was doable.

He looked out the back of the tiny control room at all of the seaweed drying in the sun on top of the sea container's roof. That was their vegetables now. Kelp.

The rice, peas, and beans were all but gone. They had kept a small handful of each, those that looked most promising as healthy seeds, in the event that they should ever get enough kelp to decompose and make a soil for the seeds to grow in. They had the space, if they could manage the dirt.

They had put down anchor where the ocean was shallow enough, radio reception was clear, the climate seemed moderate enough, the fish abundant enough, and the current seemed strong enoughthink something like half the submarine recruits scrub out because they go nuts when confined for long periods of time."

She looked him in the face, then laughed. "You're making that up—"

"Well, google me if you want, then. But it sounds right, doesn't it? One of us was sure to flip out. Eventually." He lowered his voice, "I'm just glad it wasn't your mom."

"I sure wish we could google something. I'd like to know how to make soap. We have all that bitter tasting algae, and, if I remember right, most algae has some degree of oils in it. I think you just mix that with ash or something. I mean, just taking a swim to get clean is. . . well, getting old entirely too fast."

He hadn't thought


about five miles in the storm. We're probably going to keep drifting south until. . . " something just occurred to him. "Hey, I wonder what winter will be like in Alaska?"

"Cold, I suspect."

"If it's cold enough, maybe not cold enough to snow, but just cold enough to slow the melting, that might just be enough to slow this riptide thing so we can put ashore. Maybe even in one piece!" He leaned across the table and kissed her. "I don't know why I didn't think of it before."

She smiled, "Makes sense. Alaska goes for months without seeing the sun. No matter what the solar winds are doing, if they're in the shade, snow should stop melting. It's worth giving a try, I think."

They had a plan. Notmonths. He pulled up the anchor and allowed the boat to drift in the current while he struggled to manually ready the sail.

The fabric whipped as it slapped the sides of the rigging, a cross breeze slammed it like a glove across the cabin as the tips dipped into the ocean before the craft righted itself. The sail filled like a magician pulling an elephant out of a hat, then leapt like a lion a hundred feet up, spun, then nose-dived for the ocean. Jason flipped the electric power assist back on and managed to avert disaster by steering it back into the sky. The first few minutes were always the worst, and twilight didn't make it any easier.

He let the spools reel out as the parasail soared


tiresome paddling, then carried the canoe uphill and tied it to a tree, just in case.

"The closest mansion is just over there," Jason said, "Maybe a five mile hike." He turned on the GPS, then checked his cell phone for a signal. "I wish we had an ATV or a golf cart."

Nathan rubbed his arms and stamped his feet, "I'd settle for some warm clothes."

They started to march.

The mansion, if it ever was, appeared abandoned and seemed to have suffered from the storm. Most windows were broken, roofing shingles and loose papers littered the overgrown yard. They made their way to the front door and simply knocked and shouted 'Hello' in the windows.

Nobody answered, naturally.

The door was dead bolted, so they entered through a window. Well, Nathan didand let the rest in through the door.

Water had damaged the floors by the windows and most of the nearby walls, but the furniture looked to be antiques and seemed to be holding up fine. As exciting as it was to wander through an abandoned house, even in this much disrepair, he still felt deeply out-of-place and kept looking over his shoulder for the police to cuff him and take him away. "They still shoot looters, don't they?" he said as he passed the ornate, golden mirror, then checked the phone for a dial tone.

Ava screamed from upstairs, and the two boys dropped everything to run to the rescue.

"What is it?" Jason yelled.

"What's wrong?" Nathan said, turning the other corner.

Jason entered the room first.

Ava almost collided with him,


search and found another room with additional bodies, most likely the staff. But much less tragically and more importantly, they found plenty of warm blankets, clothes, and other useful, small items that they bagged and carried down to the canoe. A dirt bike and two lawnmowers were left in the garage.

The three stayed in the mansion that night, mostly without a choice because of the tide and bitter cold. It felt haunted and dripping with the evil that had occurred in it. None of them slept a wink.

At the next low tide the following morning, Jason and Nathan canoed back to the boat, leaving a very unhappy Ava at the shore since there wasn't enough room for all three and the cargo.

While the tide was low and thedark of the night sky. "It's beautiful, no doubt. But every day we spend out here feels like we're just pushing our luck. One good storm is all it would take to end this little boat. We have to put to ground again, somewhere. Eventually. It might as well be sooner while all the equipment is still working than later, after things start breaking down."

"Panama," George continued with the program, "is starting to open for traffic, almost one year since it was decimated. This just in, the coastguard has verified that, at specific times and while holding to tightly regimented courses, boats are able to traverse the gullies that now connect the Pacific and Atlantic oceans. This is very good news indeed, because since the closing of Panama


the way he was waiting in the parkinglot."

When George came back on and introduced his psychic, alien abduction guest, they listened quietly, and Jason didn't bring up the subject again.

They brought up the nightly news to the rest of the family that morning. Nobody took it well, but it wasn't unexpected. The parasail worked perfectly in the open sea, but it proved problematic in coves and navigating channels like Panama. But Panama was still tempting, because, as devastated as that tiny country was, it was still a center for trade. If they were to get top trade for the boat, it would be there. But Panama offered something else, too. It offered access to the Gulf of Mexico and what was the Mississippi River. It was massively floodedthe roof for their night show to come on.

"The guy told me that nobody had returned to the coasts yet. Most of the over land highways to the coast remain flooded, leaving what had been the coast looking more like a string of islands, even worse than what your modified map had."

"Yeah," he said, "I got that too, just in other words. Said that the jet stream had shifted again and windmills that had been working for years have been down for months. Populations seem to be concentrating around nuclear reactors because, except for the ones that flooded, they're the only things still running 24/7/365. And you can refuel them with a few F-150s and they're good to go for another decade, coal and the rest require several


sister, then what? Huh? Does that mean you get to go ashore today? Does it? Does it mean we get a house on land, get jobs, and life returns to normal? Not likely. We'll still be exactly where we are, right now." She turned to Gina, then pushed her back down in her seat.

"He's never won a fight with me in his life—" Gina started.

"And what do you get if you win?" her mom answered, pushing Nathan back into his chair. "Do you think he'll stop stewing about all this? You think those bruises will come with an insight on patience?"

Gina stirred her mug, glared at her brother, then sipped.

"I should make you two hug, but I won't." The mother pointed at each. "Unless this happens again."

Jason climbedclimate.

In other, otherwise bad news, it seems that the war between Iran and China has burned itself out. Iran either never had nuclear weapons, or they had them and were incapable of deploying them. Either way, they never managed to mount any kind of retaliation or effective resistance and the Chinese Republican Army now has full control of Iran's southern oil fields and has resumed deliveries to China.

Skirmishes continue, but China isn't having the same problems we had in Iraq and Afghanistan. From the very beginning, they showed no compunction against killing everyone who approached their vehicles and positions. They showed no attempts to win hearts and minds, only to keep control of the fields.

Suicide bombers were, like all civilians, machine-gunned hundreds of feet away from instillations and


was finished within the first month. It was an odd little thing. Hobbled together from mostly scraps, the siding on the front didn't match the siding on the back, nor those of the two ends. The windows were recycled as well, but their differences were harder to notice. Inside, the building was 'complete' with air ducts, wiring, switches, ceiling fans and fixtures. But most walls were transparent, lacking any sheetrock to cover them, and showed naked pipes and wires everywhere. A few around the bathrooms and such had sheets stapled to the studs for privacy, but in most cases the walls were bare. No carpeting for the same reasons, simple plywood floors all around. And the roof was a mismatched patchwork of multiple shingle colors. But otherwise, theinventions, reincarnation, and hummingbirds. The first book in the series, The Art of the Houdini Scientist, is free to download through Smashwords and their distribution with the great people at B&N, Apple, Diesel, Sony, Kobo, and Amazon, with more on the way. You'll find my Houdini Scientist gets down into the science of fiction and is far better behaved.

If stories this size are more your speed, may I suggest my collection of short stories in The Twisted Timeline Trilogy. It starts with the troubles of a colonizing crew drifting through space, picks up again in modern times with a discovery of ancient high-technology that shouldn't exist, buried in a coalmine. And it ends with the story of another colonizing crew, picking up where the others left off. Three