Nationwide collaborative development of learning outcomes and exemplar standards for Australian pharmacy programmes.
Internationally, the preparation of pharmacy graduates for professional practice has evolved from educating for capacities for practice, to a focus on competencies, and most recently, on assuring graduate outcomes. Consequently, there is an increasing emphasis on the specification of and accountability around student learning outcomes. This, in turn, has implications for teaching and assessment. The aim of the study was to harmonise the various expectations and regulatory requirements for Australian pharmacy education programmes through the development of learning outcomes and exemplar standards for all entry-level pharmacy graduates. Learning outcomes and exemplar standards were developed through a participatory action research framework which involved academic staff representatives from pharmacy schools in Australia, pharmacy student representatives, and the AustralianCategory: Wholesale Jerseys China

Here’s the thing: Sean Spicer 100 percent does not “got this.” Do you remember last week, when Spicer made not one, but at least THREE separately fucked up comments about Adolf Hitler on THE FIRST DAY OF PASSOVER?

Yeah, he did that! The White House press secretary said that Hitler never gassed his own people! You know what else Sean Spicer has done? Lied with alarming regularity through the huge clumps of cinnamon gum in his mouth that he then swallows (the gum, not the lies — those, he spits out into the world).

So here’s what I’m suggesting: I think Spicer should’ve said, “You know what, Rob? I sure could use a hand!” And then stepped off the podium, walked into Trump’s office, which I guess


State team for putting together this special moment for Jarvis, which he’ll surely never forget.

Listen, we know it’s tough to catch up on everything happening in the baseball world each morning. There are all kinds of stories, rumors, game coverage, and Vines of dudes getting hit in the beans every day. Trying to find all of it while on your way to work or sitting at your desk just isn’t easy. It’s OK, though. We’re going to do the heavy lifting for you each morning and find the things you need to see from within the SB Nation baseball network, as well as from elsewhere. Please hold your applause until the end, or at least until after you subscribe to the newsletter.

Two summers ago after Jordan Spieth’s grandproximally near each other. This is unlike conventional hashing techniques where the hash values of goods with perceptually similar content are far apart with high probability in some distance sense (e.g., Hamming). This abstract itself is not intended to limit the scope of this patent. The scope of the present invention is pointed out in the appending claims.

Images(5)

Claims(28)

1. A method for hashing a digital signal, the method comprising:

transforming a digital signal into a digital signal transform;

quantizing the digital signal transform;

geometric-region-growing the digital signal transform;

generating a recognition value of the digital signal.

2. A method as recited in claim 1 further comprising:

pseudorandomly segmenting the digital signal into one or more segments;

for one or more of the segments, repeating the transforming, the quantizing, and the geometric-region-growing, wherein these repeated tasks are


entire signal;

combining one or more of the segments.

16. A method as recited in claim 14, wherein the quantizing comprises a multi-level quantization of the digital signal transform.

17. A method as recited in claim 14, wherein the recognition value is a hash value.

18. A method as recited in claim 14, wherein the self-correcting iterative filtering comprises accentuating geometrically strong components of the signal while de-emphasizing the geometrically weak components of the signal.

20. A computer comprising one or more computer-readable media having computer-executable instructions that, when executed by the computer, perform the method as recited in claim 14.

21. A method for hashing a digital signal, the method comprising:

pseudorandomly segmenting a digital signal into one or more segments;

for one or more of the segments:

transforming a segment into a segment transform;

quantizing thegeometrically strong components of the signal while de-emphasizing geometrically weak components of the signal.

26. A system as recited in claim 25 further comprising:

a segmenter configured to pseudorandomly segment the digital signal into one or more segments;

a combiner configured to combine the output of the converter for one or more of the segments.

27. A system for digital signal similarity recognition, the system comprising:

a segmenter configured to pseudorandomly segment the digital signal into one or more of the segments;

a transformer configured to transform a segment into a segment transform;

a quantizer configured to quantitize the segment transform;

a iterative geometric converter configured to convert the segment transform into a representation of the segment that emphasizes geometrically strong components of the segment while de-emphasizing geometrically weak components of the segment;

a combiner configured to


It simplifies many data management issues and reduces the computational resources needed for accessing large databases.

Mathematically, a hashing technique involves an implementation of a hashing function HK(·). That function takes a signal x as input and computes a short vector h=HK(x). That vector is an apparently random value, which is indexed by a secret key K, in some large set. That vector h is a hash value.

The use of hashing techniques are many and indeed wide-ranging: compilers, checksums, searching and sorting techniques, cryptographic message authentication, one-way hashing techniques for digital signatures, time stamping, etc. These techniques usually accept binary strings as inputs and produce a hash value having a fixed length L. Typically, these techniques use random seeds (i.e., keys) of some type.

The hash values produced by suchwould improve existing content-based key generation, which is often employed in the watermarking. These new techniques would introduce improved synchronization so as to achieve synchronization in watermarking streaming multimedia data, such as video and audio

SUMMARY

Described herein is a technology for recognizing the perceptual similarity of the content of digital goods.

At least one implementation, described herein, introduces a new hashing technique. More particularly, this hashing technique produces hash values for digital goods that are proximally near each other, when the digital goods contain perceptually similar content. In other words, if the content of digital goods are perceptually similar, then their hash values are, likewise, similar. The hash values are proximally near each other. This is unlike conventional hashing techniques where the hash values of goods with perceptually similar content


herein as a technique for recognizing perceptual similarity of content of such goods by comparing “recognition” hash values of the goods. This implementation generates proximally similar (i.e., near) unique identifiers (e.g., hash value) even though some forms of alterations (including intentional and unintentional) have been done to a specimen of the original digital good, given that the altered specimen is perceptually similar to a human observer when comparing the altered specimen with the original specimen. However, if the altered specimen is perceptually distinct, the hashing technique produces a hash value that is not proximally near the hash value of the original.

At least one implementation described herein is a technique that may be combined with the techniques described in U.S. patent application Ser. No. 09/421,986, entitled “System and Methodand translate the smaller masses more than the larger ones. The exemplary content similarity recognizer includes iterative and convergent techniques that introduce a self-correcting mechanism.

The description of the implementations of the exemplary content similarity recognizer are particularly directed towards digital goods that are images. Although that is the case, those who are skilled in the art understand and appreciate how to apply these concepts to other digital goods—such as audio, multimedia, video, etc.

Exemplary Applications

Implementations, described herein, of the exemplary content similarity recognizer are suitable for numerous applications, including the following (which are provided as examples and not as limitations): identification, searching & sorting in a database, semantic content categorization, and anti-piracy applications (such as watermarking). Some of the exemplary applications are discussed below:

Locating similar content in a database.


of a digital good (e.g., image, audio clip, etc.). Furthermore, let {circumflex over (X)} denote a modified specimen of this good, where this modified specimen is “perceptually similar” to X. Let Y denote a particular specimen of a digital good that is “perceptually distinct” from X. See the above section titled “Perceptually Same and Perceptually Distinct” and “Perceptually Similar” for more details on the meaning of such terminology.

Let L be the final length of the hash, and let HK(·) represent a hashing function that uses the secret key K. A normalized Hamming distance D(.,.) is used fro comparing two hash values which is the ration of the usual Hamming distance and the size of the imputes.

Given the above, these are the characteristics of the hash values generated bythe hashing techniques implemented by the exemplary content similarity recognizer:

Invariance under perceptual similarity:
HK(X)=HK({circumflex over (X)})→Pr└HK(X)=HK({circumflex over (X)})┘≈1.

(Invariance under perceptual similarity may also be described as approximate invariance under small perturbations.)

Hence, in addition to uniform distribution on the hash values, the following is desirable for all possible different digital goods X,Y and for all possible acceptable modified (i.e., perceptually similar) versions of X, represented by {circumflex over (X)}:
D(HK(X),HK({circumflex over (X)}))=0; and
D(HK(X),HK(Y))>0;
(with a high degree of probability)

The hashing techniques implemented by the exemplary content similarity recognizer may have two stages: Intermediate and Final.

Intermediate Stage

At the end of the intermediate stage, the exemplary content similarity recognizer obtains intermediate hash values (i.e., “recognition” values) having a length M, where M>>L and have the following separation property:
D(HK(X),HK({circumflex over (X)}))<T1; and
D(HK(X),HK(Y))>T2 (1)
with a high


which is the ratio of the usual Hamming weight and the size of the input. For a given two-dimensional matrix A, let A (i,j) represent the (ij)th entry of A.

Order-statistics filtering S[m,n],p(·): Given a two-dimensional input A, S[m,n],p (A)=B, where ∀i,j,B(i,j) is equal to the pth element of the sorted set of {A(i′,j′)}, where i′∈{i−m,i−m+1, . . ., i+m} and j′∈{j−n,j−n+1, . . . , j+n} (sorting is done in ascending order); here the term S[m,n],p(·) is the order-statistics filter. For order-statistics filtering to be equivalent to two-dimensional median filtering if, for example, for a window of size (2m+1)×(2n+1), then p is chosen as 2mn+m+n+1.

The following is a continued description of Approach A with some reiteration of the above description:

Transformation. At 218, the exemplary content similarity recognizer findsthe DWT of X up to level L. Let XA be the resulting DC subband.

Quantization. At 220, the exemplary content similarity recognizer performs a thresholding operation (e.g., 2-level quantization) on XA to produce a binary map M. The map M may be represented in this fashion: M(i, j)=1 if X(i, j)≧T or 0 otherwise. T is chosen such that the W(M)≈q, where 0<q<1 is a parameter.

Order-Statistics Filtering. It performs order-statistic filtering on M1. M2:=S[m,n],p(M1), where m, n and p are parameters.

Local Smoothing. It applies a two-dimensional linear shift-invariant filtering on M3 via filter f, where M3(i, j)=A M2(i, j); f and A are parameters. Let the output be M4.

Quantization. Apply a thresholding operation on M4. This operation is similar to the one performed in block 220. Let M5


logical connections to one or more remote computers, such as a remote computing device 948. By way of example, the remote computing device 948 can be a personal computer, portable computer, a server, a router, a network computer, a peer device or other common network node, and the like. The remote computing device 948 is illustrated as a portable computer that can include many or all of the elements and features described herein relative to computer 902.

Logical connections between computer 902 and the remote computer 948 are depicted as a local area network (LAN) 950 and a general wide area network (WAN) 952. Such networking environments are commonplace in offices, enterprise-wide computer networks, intranets, and the Internet.

When implemented in a LAN networking environment, the computer 902 is connectedBrussels: Thousands of Belgian schoolchildren skipped classes on Thursday to flood Brussels in an unprecedented protest against global warming and pollution, vowing to miss school once a week until the government takes action.

Students banging drums and carrying signs decrying man-made climate change gathered around the European Parliament.

Police said the 35,000-strong gathering was the biggest turnout of recent times for a student protest in the Belgian capital, which is also home to European Union institutions.

"If we skip every Thursday, if we don't go to school, the big people in our country and in the world will see that this is a problem," said high school student Joppe Mathys.

Another student held a sign saying: "Be part of the solution, not the pollution."

A nine-year-old girl, who gave her name only as


end may be accomplished by the forced disintegration of political and social institutions, of the culture of the people, of their language, their national feelings and their religion. It may be accomplished by wiping out all basis of personal security, liberty, health and dignity. ...Genocide is directed against a national group as an entity and the attack on individuals is only secondary to the annihilation of the national group to which they belong...

That was the definition given by the Polish Jew and legal scholar, Raphael Lemkin, when he coined the term "genocide."

In her response to the atrocities carried out by Muslim terrorists in London this weekend, Theresa May confirmed that she is either a moron or an accomplice in the destruction of England. Following the London Bridge attack,necessary to prevent something similar happening again. Once Cameron and Osborne controlled that narrative of the past, it became impossible for Labour to form a coherent one of its own in the present.

The future now belongs to the Tories; the next five years at least. They face the pressures of globalisation on one side and a rising politics of identity on the other. Local councils are fearful of what another round of cuts will do to services that have already been stripped to the bone. All this takes place within the context of an ever-growing mistrust and outright contempt for the entire political culture and its inhabitants.

The Tories might have won the election but they are just as woefully unprepared for the reality of what needs to be


and mechanisms is a slow process. They don’t suddenly appear once a dictatorship or the like is overthrown. They must be designed carefully. They have to channel what is best about us and keep in check what is worst. Self-interest at the expense of the many will always be lurking. Fear will always be used as a tool to exploit weakness and tear asunder what has been so carefully built.

It can be difficult to recognise the face of regression, because it is not the new. It has a familiarity about it and can be easily mistaken for something known and safe. Ronald Reagan, the 40th president of the United States, said: “Man is not free unless government is limited.” If the banking crash taught us anything, it is       sage: print(Hom(T,T).identity()._repr_defn())
            [0, 1, 2, 3, 4, 5, 6] --> [0, 1, 2, 3, 4, 5, 6]
        """
        vd = self._vertex_dictionary
        try:
            keys = sorted(vd.keys())
        except TypeError:
            keys = sorted(vd.keys(), key=str)
        if len(vd) < 5:
            return '\n'.join("{} |--> {}".format(v, vd[v]) for v


   sage: S = simplicial_complexes.Sphere(1)
            sage: T = simplicial_complexes.Sphere(2)
            sage: H = Hom(S,T)
            sage: f = {0:0,1:1,2:2}
            sage: x = H(f)
            sage: x
            Simplicial complex morphism:
              From: Minimal triangulation of the 1-sphere
              To:      True

            sage: S = simplicial_complexes.Sphere(2)
            sage: T = simplicial_complexes.Sphere(3)
            sage: H = Hom(S,T)
            sage: f = {0:0,1:1,2:2,3:3}
            sage: x = H(f)
            sage: x
            Simplicial complex morphism:
              From: Minimal triangulation of the 2-sphere


 sage: z = x.fiber_product(y)
            sage: z
            Simplicial complex morphism:
              From: Simplicial complex with 4 vertices and facets {...}
              To:   Simplicial complex with vertex set (0, 1, 2) and facets {(2,), (0, 1)}
              Defn: L0R0 |--> 0
                    L1R1 |--> 1
                      2 |--> L2R2

        We can view the matrix form for the homomorphism::

            sage: h.to_matrix(0) # in degree 0
            [1]
            sage: h.to_matrix(1) # in degree 1
            [1]
            [1]
            sage: h.to_matrix()  # the entire homomorphism


  sage: H = Hom(K, L)
            sage: f = H({0: 0, 1: 1})
            sage: g = H({0: 0, 1: 0})
            sage: f.is_contiguous_to(f)
            True
            sage: f.is_contiguous_to(g)
            True
            sage: h = H({0: 1, 1: 2})
            sage: f.is_contiguous_to(h)
           False

        TESTS::

            sage: one = Hom(K,K).identity()
            sage: one.is_contiguous_to(f)
            False
            sage: one.is_contiguous_to(3) # nonsensical input
            False
        """
        if not isinstance(other, SimplicialComplexMorphism):
            return False
        if self.codomain() != other.codomain() or


refreshed afterwards.

This is especially useful when you’ve got to tackle an important task or something that needs a fresh set of eyes.

I love taking a bit of time to catch up on my Twitter feed or see what other awesome creators are posting on Bloglovin! Bringing in a book to read or watching an episode of a TV series is also a great option.

It gives you a chance to get things done:

Have you been waiting all week to send an important email or buy event tickets? This is your chance.

I work over an hour away from home so my evenings are pretty limited but having a break during the day gives me a chance to feel like I’m not working 24/7.

Taking the time to tick one important thingthe detection efficiencies required for closing the detection loophole in Bell tests [@104PRL060401], higher-dimensional states are more robust against isotropic noise [@90PRL167906], qudit-based quantum cryptographic protocols may enhance the security against eavesdropping attacks [@88PRL127902], qudits can simplify quantum logic [@5NP134] and have higher capacity to carry information, and so on.

In this paper, we investigate RIC for $d$-level ($d\geqslant 2$) quantum systems, called qudits for short (when $d=2$, they reduce to qubits). It will be shown that the quantum information originally distributed into three spatially separated qudits from a single qudit by the telecloning procedure can be remotely concentrated back to a single qudit via a previously shared entangled channel assisted by local operations and classical communication (LOCC). The entangled channel can be mixed entangled states as well as


and L. C. Kwek, Phys. Rev. A **69**, 032313 (2004). B. P. Lanyon, M. Barbieri, M. P. Almeida, T. Jennewein, T. C. Ralph, K. J. Resch, G. J. Pryde, J. L. O’Brien, A. Gilchrist, and A. G. White, Nature Phys. **5**, 134 (2009). L. Szabó, M. Koniorczyk, P. Adam, and J. Janszky, Phys. Rev. A **81**, 032323 (2010). X. W. Wang and G. J. Yang, Phys. Rev. A **79**, 064306 (2009); X. W. Wang, Y. H. Su, and G. J. Yang, Chin. Phys. Lett. **27**, 100303 (2010). X. W. Wang and G. J. Yang, Phys. Rev. A **79**, 062315 (2009). V. Bužek and M. Hillery, Phys. Rev. Lett. **81**, 5003 (1998). N. J. Cerf, J. Mod. Opt. **47**, 187 (2000); Phys. Rev. Lett. **84**, 4497 (2000). D. M.Eq. (\[channelg\])\] or $\rho_{3456}$ \[see Eq. (\[channelrho\])\], in the case in which qudits 3, 4, and 5 are distributed to Bob, Charlie, and Alice, respectively.](figure3.eps){width="7cm" height="5cm"}

[^1]: xwwang@mail.bnu.edu.cn

[^2]: dyzhang672@163.com

[^3]: yanggj@bnu.edu.cn


counterpart to the Sommerfeld fine-structure formula (\[E0\]). It is $$E=\sqrt {m^2+M^2+\frac {2mM}{\sqrt {1+\frac {
\alpha^2}{(n+\epsilon +1)^2}}}}\label{SF}$$ Here $M$ is the mass of the other particle. It is easy to see that $
E-M$ reduces to the one-particle Sommerfeld fine-structure formula (\[E0\]) when $
M\rightarrow\infty$. The formula (\[SF\]) for the bound-state energies is obtained from a two-body relativistic atomic wave equation which was derived in ref. [@1991] and is repeated below.

In this work we will not be able to derive an angular equation for the angular parameter $\epsilon$ which is a two-particle counterpart to equation (\[e0\]). Therefore we have only half the analytic solution.

Nevertheless, from the two-particle Sommerfeld formula (\[SF\]) alone, assuming that $\epsilon$ exists without knowing it, we have found two predictions for order $
\alpha^6$ bound-state energy terms for any masses,which are verified by previous calculations for positronium which had to use second-order perturbation theory. These results raise the hope that it may eventually be possible to find a full analytic solution to a relativistic atomic two-body wave equation which would eliminate the need for second-order perturbation calculations to obtain energies to order $
\alpha^6$.

Two-Body Wave Equation
======================

The local relativistic atomic two-body wave equation (\[we\]) below was derived in ref. [@1991] from the Bethe-Salpeter equation for two spin-$
1/2$ constituent point particles bound by a single-photon-exchange kernel in the Coulomb gauge. The derivation used a simple quasi-potential approximation [@1967; @1971] with its associated Blankenbecler-Sugar correction series [@1966].

The masses of the bound particles are denoted by $m,M$. The bound-state energy $E$ is parametrised by a quantity $\beta$ as follows: $$E=\sqrt {m^2-\beta^2}+\sqrt {M^2-\beta^2}\label{E}$$


just and right division of the community estate.
Summary of Second Appeal
In its Second Final Decree of Divorce, the trial court awarded each party a car, a portion of the bond proceeds held in the registry of the court, and an undivided 50% interest in the remainder of the parties' community property. The trial court's judgment directed the Walstons to divide the property themselves, and if they did not, the trial court would "consider the appointment [of a] Receiver to carry out the terms of this decree." Sue appealed this judgment. In this second appeal, we concluded that the trial court abused its discretion by awarding each party an undivided 50% ownership interest in the parties' personal property rather than dividing the community property in-kind between the two parties.Services

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and dies too.

In the same series, Kenshin holds his first wife Tomoe's lifeless body when he accidentally kills her.

In Fist of the North Star, Rei's battle with Juda ends this way- Juda may have been a bastard, but hearing how his descent into madness was sparked by being unable to accept that Rei was the more talented and beautiful fighter, admiring him to the point of jealousy, perhaps even to the point where it seems Yuda might actually have been in love with Rei, is sobering. His final request is to die in Rei's arms. Even Rei is saddened by this revelation and outcome, and he doesn't deny Juda's request.

Guts from Berserk is sent by Griffith to assassinate Lord Julius, the King's brother and the man responsible foryou consider that Hannibal might be eating his heart because he has great regard for Will's courage and strength. Luckily for him, Will survives the encounter and gets Hannibal arrested.

In The Devil's Backbone Jaciento stabs Conchita while holding her in a tight embrace and cradles her against him before letting her fall to the ground.

The Mask parodies Pietà Plagiarism and this trope when Jim Carrey/The Mask is shot by Darien's goons and collapses into one of the stunned henchman's arms. Carrey coughs out, "Hold me closer, Ed, it's getting dark," and rambles on until he appears to have died. The henchman, moved, starts weeping. The movie then Breaks The Fourth Wall as an audience appears in the foreground. Carrey cries, "You love me, you really love me!" and


him quiet, his girlfriend stabs him while holding him close, pleading with him to keep imagining the future they could have had together while he dies.

In the third season of Battlestar Galactica, Saul Tigh is convinced that his wife, Ellen, has betrayed the human resistance movement by collaborating with the Cylons. The resistance leaders agree that she must be punished by death, so Saul volunteers to do the deed himself. He poisons her drink, and holds her as her last breath slowly slips away. This does his psychological state no favors.

Stargate SG-1's Sam Carter does this to Martouf after she is forced to kill him to foil his brainwashing-induced assassination attempt on the US President.

Merlin does this to Morgana near the end of season 2 after he poisonseach taken a contract for an opposing nobleman, unbeknownst to the other until the time of the duel. Both had too much honor to think of backing out, and so they fought to the death.

In the bonus chapter of Mystery Trackers 7: Blackrow's Secret Emily Lockwood holds her fiance Jeffrey Dean after accidentally shooting him with a real gun which was somehow exchanged for the prop firearm from the play both were in.

The final chapter of Oichi's story in Samurai Warriors 2 has her fight for her brother against her husband, Nagamasa. After defeating the latter, she holds him in her arms, as they exchange goodbyes and Nagamasa fades away.

In The Gamer's Alliance, Refan ends up doing this to Awar after he kills him in the aftermath of


My initial response to the question of whether the Lions should call former San Francisco 49ers Pro-Bowl linebacker Navorro Bowman was a resounding no. A quick look at some stats revealed that Bowman was giving up 8.5 yards of run after the catch.

That is exactly the opposite of what the Lions typically want from their linebackers. The Lions scheme calls for the second level of the defense to keep their man in front of them and limit their yards after the catch. Bowman also has a coverage grade of 45 from PFF. I am not a PFF zealot, but I do believe that when someone says it looks like a duck, and the numbers show that it quacks like a duck, it is almost invariably a duck.

There wasThere is no fundamental difference between a state that owns a corporation and a corporation that owns the state. In the absence of a state institution that has absolute authority, people with money will end up buying the state. In an ancap paradise, with functionally no government, one corporation or a partnership of corporations will eventually usurp the function of the state. Absent ‘regulation’ you get massive monopolies, because free competition is only a step on the way to the endstate of capitalism. Success has a snowball effect. If you manage to get bigger than your competitors, you can use your leverage to suppress competition, and it’s in your best interest to do so. It’s also in your best interest to gain control of the regulatory apparatus of


submucosa \[[@B1-sensors-19-01057],[@B2-sensors-19-01057]\]. The light penetration range into the tissue varies from 0.15 to 0.30 mm with the NBI technique \[[@B2-sensors-19-01057]\].

The diagnosis of some diseases, such as Barret's esophagus and gastric cancer, has become faster and more accurate with the NBI technique \[[@B1-sensors-19-01057],[@B2-sensors-19-01057]\]. Increasing the luminous intensity at the target area of interest is an important requirement for this imaging diagnostic method, since it allows obtainment of a higher-quality image.

Endoscopic imaging uses light not only to obtain images of internal tissue, but also for therapeutic applications \[[@B3-sensors-19-01057],[@B4-sensors-19-01057]\]. Miniaturization and high sensitivity are increasingly becoming key challenges for imaging apparatus, not only to minimize patient discomfort but also to obtain a correct diagnosis \[[@B5-sensors-19-01057]\]. Over the last few years, the advances in endoscopic imaging have provided higher-quality images and allowed  Minimum Angle (°)   Maximum Angle (°)   I(0); I(10); I(20);\   I(50); I(60); I(70);\   Wavelength (µm)
                                  Width\                                                                I(30); I(40)


"""Tests for distutils.command.bdist."""
import os
import unittest

from test.test_support import run_unittest

from distutils.command.bdist import bdist
from distutils.tests import support

class BuildTestCase(support.TempdirManager,
                    unittest.TestCase):

    def test_formats(self):
        # let's create a command and make sure
        # we can set the format
        dist = self.create_dist()[1]
        cmd = bdist(dist)
        cmd.formats = ['msi']
        cmd.ensure_finalized()
        self.assertEqual(cmd.formats, ['msi'])

        # what formats does bdist offer?
of each mutation declines with increasing numbers of mutation. Understanding whether the majority of genetic interactions are synergistic or antagonistic will help solve such problems as the evolution of sex.

The phage literature provides many examples of epistasis which are not studied under the context of experimental evolution nor necessarily described as examples of epistasis.

Experimental adaptation

Experimental adaptation involves selection of organisms either for specific traits or under specific conditions. For example, strains could be evolved under conditions of high temperatures to observe the molecular changes that facilitate survival and reproduction under those conditions.

The reader should be aware that numerous phage experimental adaptations were performed in the early decades of phage study.

Adaptation to usual hosts.

Adaptation to new or modified hosts.
The older phage literature, e.g., pre-1950s, contains numerous examples


panel where the liquid crystal cells are arranged in a matrix form and a driver integrated circuit (IC) for driving the liquid crystal cells of the LCD panel.
The LCD panel includes a color filter substrate and a thin film transistor array substrate wherein the color filter substrate and the transistor array substrate face each other and a liquid crystal layer formed therebetween.
On the thin film transistor array substrate of the LCD panel a plurality of data lines transmitting data signals supplied from the data driver integrated circuit to the liquid crystal cells are arranged. A plurality of gate lines for transmitting scan signals supplied from a gate driver integrated circuit to the liquid crystal cells are arranged perpendicular to the data lines on the thin film transistor arraysubstrate. The liquid crystal cells are arranged at intersections of the data lines and the gate lines.
The gate driver integrated circuit supplies the scan signals to the plurality of gate lines sequentially so that the liquid crystal cells arranged in a matrix form can be sequentially selected one line by one line. The data signals are supplied to the liquid crystal cells of each sequentially selected line from the data driver integrated circuit through the plurality of data lines.
A common electrode and a pixel electrode are respectively formed at the inner sides of the color filter substrate and the thin film transistor array substrate, thereby applying an electric field to the liquid crystal layer. Whereas the pixel electrode is formed correspondingly to each liquid crystal cell on the


and other cardiac diseases.

Pericarditis Diagnostics

Early diagnostics of pericarditis is the key to successful treatment and favorable forecast. The diagnosis requires a comprehensive approach to establishment of not only the type of pericarditis, but also its causes, the degree of heart failure and related diseases. When a physician suspects pericarditis, s/he prescribes:

blood tests: complete, biochemical, immunological,

ECG;

PCG captures changes in the heart tones;

X-ray reveals the increase in the size of the heart, availability of adhesions, fluid in the pericardium, and calcifications;

echocardiography is the most informative study determining a violation of heart movements, pericardial thickening and effusion increase;

MRI;

multislice computed tomography visualizes the abnormalities in the heart and pericardium;

pericardial puncture with subsequent histological and cytological analysis of the resultant material.

Pericarditis Treatment

The treatment is carried out in a hospital setting under the closesupervision of a professional who adjusts the treatment, when required. The patient is prescribed the treatment regimen and a diet, the nature of which depends on the type of pericarditis and general condition of the patient.

Sachsenhausen Hospital

Department of Cardiology, Gastroenterology and Sleep Medicine

The Department of Cardiology, Gastroenterology and Sleep Medicine covers a full range of diagnostics and treatment of all diseases of the gastrointestinal tract, liver and cardiovascular diseases. In addition, the department specializes in the study of sleep and related phenomena.

University Hospital Cologne

Pericarditis differential diagnosis and conservative treatment #78419

According to the Focus magazine rating, the Department of Cardiology, Angiology, Pulmonology and Intensive Care Medicine at the University Hospital Cologne ranks among the top German departments specializing in the treatment of cardiovascular diseases! The department provides the entire


is on cardiomyopathy in pregnancy, especially on the peripartum cardiomyopathy.

Rambam Health Care Campus

Department of Cardiology

The Department of Cardiology at Rambam Health Care Campus deals with the diagnosis and treatment of the entire spectrum of heart diseases. With 37 beds, the department is the largest of its kind in Northern Israel. The medical team consists of 22 cardiology specialists and 9 physicians.

Marienhaus Klinikum St. Elisabeth Neuwied

Department of Internal Medicine (Cardiology / Rhythmology)

The Department of Invasive Cardiology / Rhythmology at the Marienhaus Klinikum St. Elisabeth Neuwied deals with the treatment all diseases of the cardiovascular system. Cardiology covers the full range of diagnosis and non-surgical treatment of heart diseases.

District Hospital Waldbröl Oberberg

Department of Cardiology

The Department of Cardiology (Medical Department I) at the District Hospital of Waldbröl offers the entire spectrumagain. I then no longer get the warning but still get the Don't know how to build task 'db:migrate' error. Any ideas?
Doing a bundle exec rake -T yields the following:
DEPRECATION WARNING: The InstanceMethods module inside ActiveSupport::Concern will be no longer included automatically. Please define instance methods directly in ActionController::Base instead. (called from <top (required)> at /Users/Kyle/Desktop/skateparks-web/config/application.rb:4)
rake about                               # List versions of all Rails frameworks and the environment
rake assets:clean                        # Remove compiled assets
rake assets:precompile


The family 1 glycoside hydrolase from Clostridium cellulolyticum H10 is a cellodextrin glucohydrolase.
The only family 1 glycoside hydrolase in Clostridium cellulolyticum H10 (CcGH1) is annotated as a beta-galactosidase but has high sequence homology with many beta-glucosidases. Given the possible importance of beta-glucosidase in cellulose utilization by C. cellulolyticum, the encoding open reading frame Ccel_0374 was cloned and expressed in E. coli as a soluble fusion protein with thioredoxin. After tag cleavage, the purified enzyme had a molecular mass of 52 kDa and was active in dimeric form on a broad range of substrates, including cellobiose, cellotriose, cellotetraose, p-nitrophenyl-beta-glucopyranoside, lactose, and o-nitrophenyl-beta-galactopyranoside. The enzyme showed lower K(m) and higher catalytic efficiency (k (cat)/K(m)) on cellodextrins with degree of polymerization from 2 to 4 than on lactose, and the k8
Let g be 49/(-14)*(-4)/7. Let j(a) be the first derivative of 0*a**g + 0*a - 1 + 1/3*a**3. Let c(y) = 2*y**2. Calculate c(j(s)).
2*s**4
Let h(a) = -5*a - 11*a - 3*a + 13*a. Let v(d) = 12*d**2. Determine h(v(m)).
-72*m**2
Let r(q) = q**2. Let f(d) = -11*d**2 - 10. Give r(f(z)).
121*z**4 + 220*z**2 + 100
Let c(w) = w. Let i(p) = -42*p**2. Let m(k) = 42*k**2. Let g(x) = 5*i(x) + 4*m(x). Calculate c(g(f)).
-42*f**2
Let p(k) = 6*k + 5. Let r(v) = -v - 1. Let w(c) = p(c) + 5*r(c). Let l(o) = 3*o - 6*o + 0*o. What is l(w(n))?
-3*n
Let x(h) be the third derivative of 0*h + 0 + 8*h**2 + 0*h**3 - 1/12*h**4. Let y(p) = -p**2. What is x(y(m))?
2*m**2
Suppose 3*n - 5 = -0*n


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Adult WebmastersGPS position determining system includes a computer to provide digital data files of photographs with names which are particular to the locations from which the photograph is made. Such systems are first taught in exhaustive detail in U.S. Pat. No. 6,657,661 by inventor Cazier of Colorado. In a peculiar shortcoming of these systems, image files are given names associated with the places from which the image was captured rather than the names associated with the location of the image subject matter. For example, a photographer on the bayfront shore in Richmond Calif. may make photographs of San Francisco, Oakland, Alcatraz, Sausalito, Madera and San Rafael. However, all files would be named with a prefix “Richmond” in accordance with the teachings of Cazier. This, despite the fact that none


Q:

Apply visible binding progmatically with knockout

I am writing a custom binding but as part of it I need to apply a data bind for the visible binding via javascript. There seems to be little problem in getting it to work up front, however when the observable being used is updated the binding does not get re-evaluated.
Upon looking in the source code for KO there is no init event so not sure if some space magic happens at some layer to get it to re-evaluate the dom elements on the observable changing but I am unable to find this info.
So is there some specific way to create an artificial binding which re-evaluates, or do I need to create my own subscribe callback to keep re-evaluating the visible binding?
Herethe district court order state that Ms. Contreras told the officer that she arrived in Las Vegas on the morning of October 2, that statement is unsupported by the videotape of the encounter. Instead, the recording reflects that Ms. Contreras told the officer only that she had left Nebraska on September 30, driven to Las Vegas, and was now, two days later, on her way back to Nebraska. She explained to the officer that she did not like to fly. The location of the traffic stop was about a three-hour drive from Las Vegas.
Sergeant Bauer told the defendant that he was not going to give her a ticket and to "drive safe." R. Supp. Vol. I, at 4. Then, still standing at her car window, he asked, "You


investigation. "Clearly, Mills knew that an investigation would be conducted, and he understood the importance of the tape in that investigation." Id. at 1115. If conduct may obstruct a federal prosecution when no investigation is underway at all, it *1039 surely must be permissible for the obstruction enhancement to apply here, where a defendant flees the country after state investigators had uncovered evidence that would warrant federal prosecution.
A contrary interpretation would have strange consequences. Many, if not most, federal drug prosecutions occur as a result of state investigations. See, e.g. Paul G. Cassell, Too Severe?, 56 Stan. L.Rev. 1017, 1040 (2004) (noting "the increasing trend by federal prosecutors to `adopt' what is essentially a state investigation for federal prosecution"). It would make little sense to determine the applicabilitycenter)
Huntsville
Lower City
South Canaan

History
The town was incorporated in 1739. The name "Canaan" is derived from Hebrew.

Demographics

As of the census of 2000, there were 1,081 people, 445 households, and 298 families residing in the town.  The population density was 32.8 people per square mile (12.7/km²).  There were 610 housing units at an average density of 18.5 per square mile (7.1/km²).  The racial makeup of the town was 97.04% White, 1.48% Black or African American, 0.19% Asian, 0.09% Pacific Islander, 0.37% from other races, and 0.83% from two or more races. Hispanic or Latino people of any race were 0.37% of the population.

There were 445 households out of which 30.3% had children under the age of 18 living with them, 57.8% were married couples living together, 7.2% had


rather a clinically dependent step to be used for matching recording channels to corresponding electrode contacts.Fig. 2

2. Materials and methods {#s0010}
========================

2.1. Data acquisition {#s0015}
---------------------

Thirty patients (37.5 ± 13.2 years, 18 males and 12 females; 2170 strip, 538 depth, and 364 grid electrodes) with clinical cases requiring the implantation of intracranial electrodes were examined in this retrospective study ([Table 1](#t0005){ref-type="table"}), with implant locations determined by clinical necessity. The patient population came from Thomas Jefferson Hospital over the span of three years, with all cases related to intractable epilepsy. Informed consent was obtained and privacy rights were observed in accordance with IRB guidelines. The approach uses three brain images: one before any surgical procedure, the 'pre-implant MRI', and two immediately after the electrodes are implanted, an 'implant MRI' and an 'implant CT'. The(green line) to align the pre-implant and post-implant MRI. 1b. The pre-implant MRI is anatomically segmented based on a probability atlas. 2b. A parenchymal mask is created from the segmented anatomy, which excludes signal void areas such as ventricles. 3. When the mask is applied to the co-registered, post-implant MRI, the signal voids yield a set of voxels corresponding to the metal electrodes, A~MRI~.Fig. 3Fig. 4Validation and measuring electrode distances. (*Left*) All the pertinent information for electrode localization. Here, the yellow, blue, and red point clouds represent the metal artifact voxels extracted from the co-registered implant images. The yellow dots are A~CT~ and blue dots are A~MRI~; the red dots are A~ICP~ = A~CT~\*T~ICP~. The grey transparent object is the 3D rendered brain surface computed from the pre-implant MRI. (*Right*)


the electrode centroids and the nearest location on the pial surface was computed. Since grid and strip electrodes are designed to lie directly on the brain surface, the method should result in a relatively short distance to the surface when compared with other accurate approaches ([@bb0035]). The proximity of E~CT~ to the surface is referred to as P~CT~. For the two most commonly used methods of co-registration used in electrode localization, FSL4.1 and SPM12, the P~CT~ was calculated. The proximities of the electrode location E~MRI~ to the surface is called P~MRI~ ([Fig. 4](#f0020){ref-type="fig"}). The population of proximities was compared using a paired-sample, non-parametric Wilcox Signed-Rank test ([@bb0030]). The non-parametric effect sizes are reported as the average of 3 separate "effect sizes" for the non-parametric Wilcox signed-rank test. 1.MRT */
#define D3DPMISCCAPS_FOGVERTEXCLAMPED           0x00100000L /* Device clamps fog blend factor per vertex */

/* D3D9Ex only -- */
#if !defined(D3D_DISABLE_9EX)

#define D3DPMISCCAPS_POSTBLENDSRGBCONVERT       0x00200000L /* Indicates device can perform conversion to sRGB after blending. */

#endif // !D3D_DISABLE_9EX
/* -- D3D9Ex only */

//
// LineCaps
//
#define D3DLINECAPS_TEXTURE             0x00000001L
#define D3DLINECAPS_ZTEST               0x00000002L
#define D3DLINECAPS_BLEND               0x00000004L
#define D3DLINECAPS_ALPHACMP            0x00000008L
#define D3DLINECAPS_FOG


0x00000040L /* device can do vertex tweening */
#define D3DVTXPCAPS_TEXGEN_SPHEREMAP    0x00000100L /* device supports D3DTSS_TCI_SPHEREMAP */
#define D3DVTXPCAPS_NO_TEXGEN_NONLOCALVIEWER   0x00000200L /* device does not support TexGen in non-local
                                                            viewer mode */

//
// DevCaps2
//
#define D3DDEVCAPS2_STREAMOFFSET                        0x00000001L /* Device supports offsets in streams. Must be set byof obvious."

Clearly, I had an unpopular opinion. No one seemed to appreciate my candidness regarding bowel moments.

I'll be honest, I've felt awkward on dates when I needed to go to the bathroom. I usually avoid using the restroom in his apartment, if I can.

However, I'm also a girl with a supremely sensitive stomach. Withholding my sh*t doesn't exactly go hand-in-hand with being both lactose-intolerant and permanently needing to be nearby a bathroom.

Guys, stop pretending girls don't poo.

A guy I once dated actually told me he didn't believe girls used the bathroom for anything other than peeing until he was 17. Really? I'd say he also didn't know where babies came from, but I'd be lying.

Look, I get it. The “girls don't fart” joke was funny up until we


Nebraska, one of the most successful bluebird recovery programs in North America , and chairman of the Nebraska Birding Trails Project. In 2005, Dave was awarded the Journal Star, Howard Weigers Outstanding Wildlife Conservation Award. Dave, and his wife Linda, are both active on the birding trails project and Nebraska’s birding initiative program, the Nebraska Bird Partnership where Dave is an At-Large Steering Committee member representing the business community. Apart from supporting and participating in a number of other conservation groups, Dave is a Teacher/Naturalist at the Pioneers Park Nature Center in Lincoln, NE, , where he helps to educate children and adults on a variety of nature topics. Dave was the 2002 recipient of the Edna M. Shields award “Sharing Nature With Children” and in 2011 receivedunclustered strains) suggesting divergent evolution (Figure [1](#F1){ref-type="fig"}). Further information associated with phylogenetic placement of the studied *A. terreus* is available in Dryad Digital Respository as <http://dx.doi.org/10.5061/dryad.590j0>. This strain (GenBank® accession number KC305600), hereinafter designated as *A. terreus,* produced small aseptate phialidic conidia (2.1--2.3 μm diameter), with 2--3 deep grooves that tapered into a hornlike projection (Figure [2](#F2){ref-type="fig"}A). Clinical strain previously described based on scanning electron microscopy (SEM) micrograph \[[@B6]\] had no hornlike projection and no deep grooves.

![**Molecular phylogenetic analysis by Maximum likelihood method (ML) based on the K2 + G substitution model.** AIC is 1953.78, BIC is 2311.02; the highest log likelihood is −953.45 and bootstrap values ≥ 50% from 1000 iterations are shown. Blue highlighted strain of *A. terreus* (GenBank® accession number KC305600) causes foliar necrosis of potato. The ML analysis was performed in


invasion. Spot-4 was identified as patatin precursor, non-sucrose-inducible (PPSI) of potato. Spot-5 was identified as class I patatin of potato having lipase activity. Spot-6 was identified as a transporter protein expressed by *A. terreus*, as a result, this peptide spot did not match with any peptide spot on control tuber slice (Figure [12](#F12){ref-type="fig"}B, C). Noteworthy, most of the conspicuous untagged spots on the 2-D gels (Figure [12](#F12){ref-type="fig"}B, C) were identified as fragments of patatin (data not shown). Overall, results suggest most of the identified differentially expressed proteins on colonized potato tuber had enzymatic activities as well as defense related putative functions (Figure [12](#F12){ref-type="fig"}D: Table [1](#T1){ref-type="table"}). Worth noting, results from MALDI-TOF/TOF MS/MS analysis produced some variations in experimental and theoretical *pI* and Mr values (Table [1](#T1){ref-type="table"}). Such variations are common in mass peptide fingerprintingthat can occur day or night You should hire a lock expert to do the upgrades on your security to stop the possibility of being the victim of such crimes. Counting on the assistance of a trusted locksmith company that offers competent services for automotive, commercial and [...]

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Like our GiveMeSport Facebook Page and you will get this directly to you.uM significantly attenuated TNF-α/IFN-γ-indueced Caco-2 monolayer barrier injury. The increased expression of MLCK and increased phosphorylation level of MLC induced by TNF-α/IFN-γ was also inhibited significantly by NaHS. Additionally, NaHS inhibited TNF-α/IFN-γ induced activation and nuclear translocation of NF-kB p65. The present study reveals the protective effect of H2S on TNF-α and IFN-γ-induced injury of intestinal epithelial barrier function in Caco-2 monolayers and suggests that the suppression of MLCK-P-MLC signaling mediated by NF-kB P65 might be one of the mechanisms underlying the protective effect of H2S.


All the Details from Nicky Hilton and James Rothschild's Wedding

Nicky Hilton tied the knot Friday in a celebration fit for a princess — the wedding was held at Kensington Palace, after all! And we've got the scoop on everything from her celebrity-strewn guest list to a veil mishap that could have ruined her custom bridal ensemble but didn't.

You've already seen Hilton's jaw-droppingly gorgeous $75,000 Maison Valentino gown, which featured an illusion high neck and layers of laser-cut floral lace. But beneath that flowing skirt, the bride paired white pumps with the couple's initials, wedding date, and her new moniker, Mrs. Rothschild, embellished on the heels and shown in this Instagram image. So sweet!

As she walked from a Bentley toward Kensington Palace's Orangery, where she would exchange vows withand WOA quite possibly require nothing more to understand than the HTTP specification.

Of course, the HTTP specification is not the end of the story, just the essential beginning for adaptive design. Other specifications and systems layer upon this foundation. But, the key point is that if you can be cool with HTTP, you are doing it right to be a Web actor. And being a cool Web actor means you will meet many other cool actors and be around for a long, long time to come.

Concept “Routers” for Information

An understanding of HTTP can provide similar insights with respect to data and data interoperability. Indeed, the fancy name of linked data is nothing more than data on the Web done right — that is, according to the HTTP specifications.

Just


a relatively arbitrary refractive index distribution and can mass-produce preforms having a large diameter.
FIG. 1 shows an outline of one example of an apparatus for fabricating an optical fiber preform. In the drawing, a starting material, on which glass particles (soot) are deposited, is constituted by welding a dummy rod 2 at both ends of a core rod 1, and both ends are supported by an ingot chuck mechanism 4 so as to be rotatable about an axis thereof. A freely movable burner 3 is arranged in the direction of the starting material. Vapor of an optical fiber source material such as SiCl4 and combustion gas (hydrogen gas and oxygen gas) are blown from the movable burner to the starting material, and soot generated by the hydrolysis inin which, when denoting the focal length of a plurality of small diameter ejecting ports by L1 and the distance from the tip of the small diameter ejecting port to the glass particle deposition plane of a preform by L2, it is proposed that L1 is larger than L2. Inversely, Japanese Patent Application Laying-Open No. 2003-226544 has disclosed that the deposition efficiency can be improved by making L1 smaller than L2 to enhance the mixing efficiency of the gas.
However, in the OVD method, in which glass particles generated in a burner flame are deposited and adhered onto a rotating starting material while causing the burner or the starting material to relatively reciprocate, the weight of the preform increases and the diameter of a deposited body increases as the


it_end = ops.options.end();
        while(it != it_end) {
            std::cout << it->first << ": ";
            BOOST_FOREACH(std::string value, it->second) {
                std::cout << value << " ";
            }
            std::cout << std::endl;
            ++it;
        }
        return;
    }

I realize that Istd::string& trimEnd(std::string& strToTrim)
{
    strToTrim.erase(std::find_if(strToTrim.rbegin(), strToTrim.rend(),
                                 std::not1(std::ptr_fun<int, int>(std::isspace))).base(), strToTrim.end());
    return strToTrim;
}

// Trim from both sides.
static std::string trimStr(const std::string& strToTrim)
{
    std::string ret = strToTrim;
    return trimStart(trimEnd(ret));
}

// Split the given instruction into its building blocks: opcode, operands, binary representation and offset.
static bool ExtractBuildingBlocks(const std::string& isaInstruction, std::string& instrOpCode,
                                  std::string& params, std::string& binaryRepresentation, std::string& offset)
{


   {
            std::string codeLenText(matchInst[2].first, matchInst[2].second);
            m_CodeLen = atoi(codeLenText.c_str());
            retVal = true;
            break;
        }
        else if (boost::regex_search(isaLine, matchInst, codeLenInByteNI))
        {
            std::string codeLenText(matchInst[2].first, matchInst[2].second);
            m_CodeLen = atoi(codeLenText.c_str());
            retVal = true;
     instStream << std::hex << inst32Text;
                instStream >> inst32;
                instParseOK = Parse(isaLine, asicGen, inst32, srcLine, srcLineNum, false, 0, iLabel, iGotoLabel, iLineCount);
                iLabel = iGotoLabel = NO_LABEL;
            }
            else if (iLabel != NO_LABEL)
            {


days before the in vivo experiments. Next, 5 × 10^6^ cells were mixed with 7 mm × 5 mm × 2 mm Bio-Oss Collagen (Geistlich, GEWO GmbH, Baden-Baden, Germany), incubated for 1 h at 37 °C, and then implanted subcutaneously into the dorsal surface of 8-week-old BALB/c homozygous nude (nu/nu) female mice (*n* = 6 per group). The mice were randomized into 5 groups: shNC-hBMSCs/Collagen group, sh*MIR22HG*-1-hBMSCs/Collagen group, sh*MIR22HG*-2-hBMSCs/Collagen group, NC-hBMSCs/Collagen group and *MIR22HG*-hBMSCs/Collagen group. The implants were collected after 8 weeks and fixed with 4% formalin, decalcified, and embedded in paraffin wax. Sections (5 μm) were cut and stained with HE, Masson's trichrome and immunohistochemical analysis. Immunohistochemical analysis was performed to detect the expression level of osteocalcin (OCN) (anti-OCN, Cell Signaling Technology).

RNA sequencing {#Sec12}
--------------

Total RNA isolated from *MIR22HG* knockdown or shNC hBMSCs was used as input material for the RNA sampleTriton X-100 at 4 °C for 5 min. Subsequently, cells were prehybridizated at 37 °C for 30 min and then hybridized with anti-*MIR22HG*, anti-U6, or anti-18S oligodeoxynucleotide probe at 37 °C overnight. Then the cells were stained with DAPI for detection of nuclei and captured using a confocal microscope (Carl Zeiss, Germany).

Subcellular fractionation {#Sec14}
-------------------------

Nuclear and cytoplasmic fractions of hBMSCs were separated using a Nuclei Isolation Kit (Invent-biotech, Minnesota, USA). RNA was isolated from both fractions with Trizol and then reverse transcribed into cDNA. The RNA expression was quantified by qRT-PCR as described above^[@CR19]^. *MALAT1* and *GAPDH* were used as fractionation indicators. The primers used are listed in Supplementary Table [1](#MOESM9){ref-type="media"}.

Colocalization of *MIR22HG* and PTEN {#Sec15}
------------------------------------

The colocalization of *MIR22HG* and PTEN was performed as previously described^[@CR22]^. After hybridization with an anti-*MIR22HG* probe (RiboBio), hBMSCs


knockdown hBMSCs were shown in the heat map. *p* value \<0.05 and fold change \>2 were set as restrictive conditions to identify the differentially expressed genes. **b** The differentially expressed genes were counted; among these genes, a total of 278 genes were upregulated and 112 genes were downregulated. **c** KEGG pathway analysis showed the genes downregulated by *MIR22HG* knockdown might be related to different pathways, among which the top-ranking enriched pathways were shown.

Furthermore, Western blot showed the level of p-AKT was significantly decreased in the sh*MIR22HG* hBMSCs (Fig. [6a, b](#Fig6){ref-type="fig"}), which was consistent with the result of RNA sequencing. We therefore hypothesized that *MIR22HG* might promote the osteogenic differentiation of hBMSCs with the involvement of AKT signaling.Fig. 6*MIR22HG* knockdown inhibited AKT signaling.**a** The expression levels of total AKTinduction. LY294002 (10 μM) was incubated for 14 days. DMSO was used as control. Results are presented as the mean ± SD, \*/^\#^*p* \< 0.05, \*\*/^\#\#^*p* \< 0.01, \* compared with NC, ^\#^ compared with *MIR22HG*. LY: LY294002.

The role of PTEN in *MIR22HG*-mediated osteogenesis {#Sec26}
---------------------------------------------------

Previous studies demonstrated that PTEN inhibits the activation of downstream proteins of AKT signaling^[@CR23]^, we hypothesized that PTEN played a role in the *MIR22HG*-mediated osteogenesis. Therefore, we next performed Western blot analysis of PTEN in *MIR22HG* knockdown or overexpressed hBMSCs. We found that *MIR22HG* knockdown significantly increased the level of PTEN and decreased the level of p-AKT, whereas *MIR22HG* overexpression had an opposite effect (Supplementary Fig. [5A, C](#MOESM6){ref-type="media"}). To determine the effects of PTEN in *MIR22HG*-mediated osteogenesis, we transfected sh*MIR22HG* hBMSCs and the control group (shNC) with si-PTEN. As shown in


to congratulate him. My friend, I care not whether your hand be hard or soft; I care not whether you are from the office or the shop; I care not whether you preach the everlasting gospel from the pulpit, or swing the hammer over the blacksmiths anvil; I care not whether you have seen the inside of a college or the outsidewhether your work be that of the head or that of the handwhether the world account you noble or ignoble: if you have found your place, you are a happy man. Let no ambition ever tempt you away from it, by so much as a questioning thought I say, if you have found your placeno matter what or where it isyou are a happy man. I giveyou joy of your good fortune; for if you do the work of that place well, and draw from it all that it can give you of nutriment and discipline and development, you are, or you will become, a man filled upmade after Gods patternthe noblest product of the world,a self-made man.


take cuttings from known plants.

Grief, I was slightly shocked too. I have bought many seeds from Plantworld and find them to be a reliable source of many really unusual plants but really, wild bramble?
Honestly, even if you do not want to buy a named plant, you can easily propagate your own brambles by tip layering a suitable variety (if you know of anyone growing some you fancy, including handy thornless types). Simply bend the end of a cane into a pot of soil, pin with wire to anchor in place and forget about it for6 months - by autumn, you will have a nice little plant of your own and can sever it away from the mother plant.
Vegetative propagation is the only reliable way to get good berriesglyphicon-trash"> Remove
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death on the cross, would rise and would return to heaven at the Ascension. How would his followers know that they were forgiven, when they couldn’t hear those words from Christ in person?

Christ promised to be with his Church until the end of time; but he wouldn’t be here on earth physically and visibly. He delegated the power to forgive sins to other men, the Apostles who would lead his Church, so that future generations could feel confident that they were forgiven. He gave the power to forgive sins to the Apostles, who in turn passed it along to their successors, the bishops and priests.

So plan this week, as Lent is getting underway, to take advantage of this sacrament of healing, this great gift which Christ left forMcLellan to serve as the Kings new head coach 🚨https://t.co/dyNNKAasbk — LA Kings (@LAKings) April 16, 2019

McLellan, 51, signed a five-year contract worth about $5 million annually, according to a person familiar with the situation. That’s a significant term and salary, particularly for an organization that has recognized that it is years away from contending.

But Blake targeted McLellan from the get-go after a disastrous season that included the firing of John Stevens in November and a rocky six-month adventure with since dismissed interim coach Willie Desjardins. The Kings are not believed to have gotten deep into the search process with other potential candidates, even after a report last week that McLellan was close to signing with the Buffalo Sabres. McLellan will be formally introduced Wednesday as the team’s


by modulating the genes involved in lipid metabolism \[[@B14-cells-09-00923],[@B15-cells-09-00923],[@B16-cells-09-00923]\]. PPAR signaling is associated with cell proliferation, energy homeostasis, tumorigenesis and metabolic disorders \[[@B17-cells-09-00923],[@B18-cells-09-00923],[@B19-cells-09-00923]\]. These previous studies have all suggested that PPAR is a downstream candidate of Wnt/β-catenin pathway and has a potential role during bovine embryonic development \[[@B19-cells-09-00923],[@B20-cells-09-00923]\].

There are several contrasting studies on the role of Wnt signaling during the early period of embryonic development. In one study, it has been shown that the inhibition of Wnt signaling does not compromise the development of embryos to the BL stage. It also claimed that the activation of Wnt signaling by blocking glycogen synthase kinase 3 (Gsk3) activity with LiCl2 or CT99021 had inconsistent effects on development to the BL stage \[[@B21-cells-09-00923]\]. However, the clear role of Wnt pathway hasnot been determined to date. Thus, we aimed to investigate the critical involvement of Wnt /β-catenin pathway in synergism with PPAR signaling during the pre-implantation period of bovine embryo. We hypothesized that the complex formed between β-catenin and PPAR with TCF would promote the expression of WNT targeted genes and regulate the BL development. In the present study we stimulated Wnt activity with the small molecule 6 bromoindurbin-3'oxime (6-Bio) a potent agonist of Wnt/β-catenin signaling pathway. The exogenous stimulation of Wnt activity in early bovine embryos up regulated PPARδ expression and promoted PPARδ binding with β-catenin. This binding regulated the expression of several downstream Wnt target genes that, in turn, enhanced the BL development and hatching.

2. Materials and Methods {#sec2-cells-09-00923}
========================

All surgical procedures and experiments were conducted under the


performed in 10 to 11 reciprocal sets of independent experiments. Based on the blastocyst development and hatching rate, 15 µM dose showed maximum effect on PPARδ activity. For further analysis, 15 µM dose was used.

2.3. Aspiration of Oocyte and In-Vitro Maturation {#sec2dot3-cells-09-00923}
-------------------------------------------------

Oocyte aspiration and in-vitro maturation procedure was performed as described previously \[[@B22-cells-09-00923]\]. Briefly, abattoir collected ovaries were washed with Dulbecco's phosphate buffered saline (D-PBS). COCs were aspirated in TL-HEPES medium supplemented with 100 IU/mL penicillin, and 0.1 mg/mL streptomycin. Oocytes with compact layer of cumulus cells were collected and washed in TL-HEPES medium. Following washing oocytes were cultured in NUNC 4-well plates containing 700 μL of IVM medium. After 22 h of in-vitro maturation, COCs were in-vitro fertilized with frozen-thawed semen straw.

2.4. In-Vitro Fertilization and In-Vitro Culturedevelopmental stage embryos and BLs were fixed with 4% (*w/v*) PFA (paraformaldehyde) solution, and permeabilized with 0.5% Triton X-100. After blocking, sequentially incubated with primary antibody overnight and secondary antibody either conjugated with FITC or TRITC for 1 h at RT. Samples were washed extensively with PBS/polyvinylpyrrolidone (PVP) and the nuclei were counterstained with DAPI for 5 min at RT. Images were viewed under a confocal laser microscope (Olympus, FV1000). The antibodies used for immunofluorescence are listed in [Table S2](#app1-cells-09-00923){ref-type="app"}.

2.7. Quantification of Lipid Content by Fluorescent Probe Nile Red {#sec2dot7-cells-09-00923}
------------------------------------------------------------------

To analyze the accumulation of lipid droplets, a fluorescent probe (Nile red, NR) specific for intracellular lipids was used to evaluate the lipid content in the day-8 fixed BLs. NR stock solution was prepared by dissolving 1 mg/mL in


and implantation competency of BL. Our study, for the first time, unfolded the physiological significance of canonical Wnt pathway with PPARδ signaling in bovine BL development.

All members of I.-K.K.'s laboratory are appreciated for their help and support.

The following are available online at <https://www.mdpi.com/2073-4409/9/4/923/s1>, Figure S1: Mean florescence intensities of β-catenin in control and 6-Bio treated groups at different stages of embryonic development, Figure S2: Effect of dose dependent inhibition of PPARδ function on BL development and hatching rate, Figure S3: Brdu proliferation assay in Wnt agonist and PPARδ antagonist treated group, Figure S4: Quantification analysis of β-catenin and PPARδ expression, Table S1: List of qRT-PCR primers, Table S2: List of antibodies, Table S3: Effect of PPARδ inhibitor on bovine blastocyst development and hatching.

######

Click here for additional datastop about one-half to one block away, and about two minutes after he was aware of the problem. He then got out of his seat and tried to get between the whites and the blacks, telling them to quiet down or they would be in trouble. He was struck by a belt swung by one of the blacks. He then pushed past the group, got out of the bus and called his dispatcher from a phone on the corner, and the dispatcher in turn called the police. He stated the whole incident took place in only two minutes and that he brought the bus to a stop as soon as he was able to do so because of the traffic, that he attempted to intervene on the part


still finding mud in places I din't think was possible.

As an instructor for our Windermere Ninja Installation I’ve come to learn that everyone can have success. It does not matter your upbringing, your education, your income or lack thereof. I have heard amazing stories from all walks of life. Hardships, life struggles, yet these individuals find a way to dig deep and become what they always knew they could be.

There are 3 main ingredients that I see in these types of individuals.

1.Self Esteem. They have an internal voice that says ‘I am” it says ” I can” and ‘I will” That voice inside does not doubt itself. That voice is loud with positive reinforcement and does not let negativity disrupt it’s forward momentum. This doesn’t mean there isn’tfailure curve are pulled by the past. And a surefire way to be forced to live as a prisoner of your past is to not complete things."

The book the slight edge is a powerful and thought provoking book that I guarantee will help you to look at your life differently. It has helped me to better understand how every decision I make in life has a negative or positive impact on my future.

I'd like you to meet Joie Gowan. Joie as been in the real estate business for over 25 years. I walk past her office daily on the way to my office. Today I walked by and noticed over 100 of these on her floor.

I asked Joie what they were? She told me they are shopping bags


15,500 calories . How about over a year, how about over 5 years?

Many times we set a hurdle in our mind about how the change is too difficult. We don't visualize that change every day and then we never are able to see the long term impact. This is why 95% don't succeed. Not sure but I'm willing to put the effort in everything I do to be in the 5%.

I am re-reading a book called the Slight Edge by Jeff Olson. Great book. In his book he maps out the 7 Slight Edge principals. I'm just talking about the first two. The first two seem so evident and simple but I'm amazed at how many people apparently don't get this. BTW I'm not immune to not gettingthis either. after re-reading this book I know I have some work to do.

1. Show up. 80% of winning in many cases is just showing up. I can't tell you how many excuses I hear for not being able to show up. We have become a society that doesn't take this to heart. Let me add a caveat to showing up, "on time"

One of the things that drives me crazy is being late. I tell my kids that being late is not acceptable. In fact being on time is getting there 5 min early. When you are late it is a reflection that you are thinking about yourself and no one else. You demonstrate a lack of respect for the person who is waiting for you. Not showing


to their parents in almost every way that mattered. They were less Godly, less moral, less charitable, less patriotic, less industrious, less ambitious, lazier….but they would certainly never admit that to themselves. So, they looked at the very, very limited subset of things that they did better than their parents and they created a pseudo-morality based on tolerance, diversity, and “not being mean.” That’s an extraordinarily thin group of minimally important virtues for any group of people to hang their hat on, but it’s what they had to work with.

The problem with this pseudo-morality is that it has now been taken to its natural conclusion and it’s doing more harm than good. We’re creating a nation full of man-children because every stupidity and immorality you can think ofintent to intimidate on the part of the speaker) is sufficient to bring the proscribed speech out of the realm of protection by the Constitution. However, the release of personal information, even with the intent to intimidate, is not per se a true threat. Id.
"True threats' encompass those statements where the speaker means to communicate a serious expression of an intent to commit an act of unlawful violence to a particular individual or group of individuals." Virginia v. Black, 538 U.S. 343, 359, 123 S.Ct. 1536, 1548, 155 L.Ed.2d 535 (2003). "Intimidation in the constitutionally proscribable sense of the word is a type of true threat, where the speaker directs a threat to a person or group of persons with the intent of placing the victim in fear


it is "narrowly tailored to a state interest of the highest order." Florida Star at 541, 109 S.Ct. 2603.
While the state interest of protecting police officers from harm or death may be compelling, § 843.17 is not narrowly tailored to serve this interest. Section 843.17 fails to require there be a credible threat of danger to the officer, and thus fails to proscribe "true threats."[1] The statute is therefore both underinclusive and overinclusive. It is overinclusive in proscribing speech that is not a true *1250 threat. It is underinclusive both in its failure to prohibit dissemination of the same information by other entities to third-parties who do intend to harm or intimidate officers, and in its failure to punish parties who actually wish to harm or intimidate policeepithelial dysplasia, two with epithelial dysplasia and five with squamous cell carcinoma. (i) Group without lesions. Statistical analysis revealed a smaller number of superficial cells with nuclei in all sites of the group of tobacco/alcohol users (group III) when compared to the control group (group I), and this difference was statistically significant (P<0.005). (ii) Group with lesions. The severity of histopathological findings increased with the increase in the number of cells of the deeper epithelial layers, with a statistically significant difference in the number of intermediate (P=0.013) and parabasal cells (P=0.049), which increased with the severity of the epithelial maturation disorder: leucoplakias with dysplasia had a greater number of intermediate and parabasal cells than leucoplakias without dysplasia; and the number in squamous cell carcinomas was greater than in


Hamas. He also defrauded his employer of $610,000 in a scam unrelated to HLF. Moreover, he cheated on his taxes and lied to the FBI. As part of a plea bargain, he agreed to lie again under oath – against innocent HLF principles.

(3) The court allowed irrelevant prejudicial evidence to be presented. It included alleged Hamas suicide bombing exhibits, killing Israeli collaborators, a video showing demonstrators stomping on and burning the American flag, and more. All of it was unrelated to the case.

(4) Irrelevant prejudicial testimonies were also allowed, including erroneous legal and religious opinions.

(5) At the same time, the court denied defense attorneys the right to review government recorded, intercepted, or otherwise gotten statements, based on Foreign Intelligence Surveillance Act (FISA) authority.

FISA, in fact, is classic policedescription

With three hands and a discreet date display, Portofino Automatic is the epitome of good taste. The stainless steel case has grown to a contemporary 40 mm diameter and is adorned by a black dial. The solid, mechanical automatic movement reliably ticks away the time.


characterized as involuntary, in derogation of the requirements imposed by Fed.  R. Crim.  P. 11, or otherwise legally suspect....

11
Parrilla-Tirado, 22 F.3d at 371 (footnote and citations omitted).

B. Section 1014

12
Section 1014 prohibits persons from "knowingly make[ing] any false statement or report ... for the purpose of influencing in any way the action of ... any institution the accounts of which are insured by the Federal Deposit Insurance Corporation ... upon any application ... or loan...."  To convict a defendant under Sec. 1014, the government must prove that

13
(i) the defendant made or caused to be made a false statement or report to a bank upon an application, commitment or loan, and that the false statement concerned a material fact;  (ii) that the defendant acted knowingly; (1992).

15
Further, materiality "is not merely directed to false statements which are actually used in the decision to make a loan."  United States v. Goberman, 458 F.2d 226, 229 (3d Cir. 1972) (emphasis added).  That is, the government is not required to show that the lending institution actually relied on the defendant's statements in making its decision to approve a loan.  Id. See Haddock, 956 F.2d at 1550 (actual reliance need not be shown to meet materiality requirement);  United States v. Wilcox, 919 F.2d 109, 112 (9th Cir. 1990) ("no actual influencing need be demonstrated");  United States v. Norberg, 612 F.2d 1, 4 (1st Cir. 1979) ("[i]t is not the result of the transaction upon which the statute focuses, but the purpose").  As


mean it’s pretty easy right?

You get off whatever birth control you’re on and do the thing, and

WABOOM.

There’s a baby in your belly.

I have always heard about infertility, about people struggling to get pregnant.

Of course, my heart went out to them.

But that would never happen to me.

I’m healthy, and active, and I mean – I’ve always wanted to be a mom.

I mean, half my friends got pregnant without even blinking,

so I’m bound to get pregnant the first time I try, right?

It’s funny — when you make the choice to have a baby…

You start thinking of how you’re going to tell people.

How you’re going to tell your husband, your mom, your best friend.

You think of how surprised and excited everyone is going to be.

You picture all of this in yourattributeIndex, int[] rawData)
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    GL.EnableVertexAttribArray(attributeIndex);
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    return bufferIndex;
}

And I'm getting all zeros for vec4 'in_color' in vertex shader. Not sure what's wrong.
Closest thing what I found: https://www.opengl.org/discussion_boards/showthread.php/198690-I-cannot-send-RGBA-color-as-unsigned-int .
Also in VertexAttribIPointer I'm passing 0 as a stride, because I do have VertexBufferArray and keep data separated. So colors come tightly packed 32 bits (per color) per vertex.

A:

Aight, so this did the job for me:
Having managed data as int[] where it's tightly packed array of only colors (where int format is: RGBA meaning 0xAABBGGRR), then defining vertex attribute as: GL.VertexAttribPointer(index, 4, VertexAttribPointerType.UnsignedByte,


chip layers. Each alternation between a chip layer and an interface structure adds to the cost of the handling equipment required to assemble a stack.
U.S. Pat. No. 4,956,694 (filed Nov. 4, 1988 by Eide et al.) teaches a configuration for stacking slightly differing LCC chips onto a small substrate that can then be mounted sideways on a larger substrate. This stacked device relies on these slight differences between the dies to function, because exactly identical IC dies connected exactly in parallel are unable to perform logic functions individually. A second problem not yet adequately addressed in the art is that stacked device configurations of this type require that the dies be fabricated using different masks, and are subsequently maintained in distinct inventories. A need thus exists for stackedThe present invention relates to devices for attracting metal pieces present on a surface.
The surface areas of industrial and educational work spaces require regular maintenance. For example, machining of a metal workpiece in an industrial work space creates metal chips that litter the surface of the work space. The chips must then be removed from the surface to maintain the industrial work space. Frequently, the chips litter the surface of the work space that lies between a wall of the industrial work space and the side wall of a structure (e.g., a machine) present in the industrial work space. Chips littering such tough to reach surfaces hamper the efficient removal of the chips from the surface. The device of the present invention addresses this problem.


Company, with UM limits of $50,000/100,000.[1] The accident was in Pennsylvania, while Hennessey occupied a New Jersey auto owned by a New Jersey resident, Linda Robinson, and insured by Rutgers Casualty Insurance Company, with UM limits of $15,000/30,000.
The accident occurred after Robinson, Hennessey and another woman, all nurses, came upon an earlier road accident and stopped to render aid. Robinson and, later, the third woman left the car to see if they could help. A man who was involved in the accident came and sat down in the Robinson car. He then unexpectedly drove the car away, with Hennessey an unwilling passenger, and struck a telephone pole, injuring Hennessey. The man was uninsured.
Hennessey unsuccessfully sought UM benefits from both carriers. State Farm took the position that under Pennsylvaniato run the bat file. During the creation leave the "Triggers" section empty, check the "run with highest privileges" box, enter a user account that has the rights you need and enter the password. Then go to "Settings" and check the "Allow task to be run on demand" box.
Now the second part (OPTIONAL). Adept the user policy on the server so that the users you want to be able to execute the process are allowed to trigger scheduled tasks on the server. You could also enter the users PCs as "trusted" on your server. There are several ways to achieve that. However, afterwards the users must be able to execute scheduled tasks on the server.
Now you are done! If you've done the optional section your users can trigger


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nice returning group," Solper said. "We've got another strong senior class. Our juniors have been really an outstanding class ever since their freshman year. We have two good classes at the top of our roster that can be good mentors and leaders for our younger athletes."

After claiming the West Region championship last year, Minot placed second behind Century at the state meet. The Magicians took third in 2012 following a crazy finish that featured a tie for first between Fargo North and West Fargo.

Solper said schools like North and Mandan have had winning traditions for years, and in recent years "other communities in our state are really developing and growing their programs," making for a more competitive field.

He dubs Century as a favorite to repeat. But Mason Bahl


turned out to vote.

Image copyright Getty Images

Analysis by Professor John Curtice, Strathclyde University

At first glance the SNP scored another remarkable success in last week's local elections. The party won 431 seats, 155 more than their nearest rivals, the Conservatives.

Meanwhile, Labour, who once dominated local government in Scotland were even further behind.

Equally, the official tally of the parties' share of the first preference vote across Scotland as a whole, which was published today, confirms that the SNP was well ahead of the rest of the pack.

However, the task facing the SNP next month is to defend its remarkable success in winning 56 out of Scotland's 59 seats, a success based not on winning a little less than a third of the vote, as on Thursday, but rather on securingTrue Sub-1° 4D Image Radar

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Software and the radar control algorithms are key to accuracy and perfection in sensing department.

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increased ceramides may play roles in RSV infection or replication in *L. striatellus* since ceramide accumulation has been shown to facilitate Japanese encephalitis virus entry and infection in Huh cells ([@iew111-B2]; [@iew111-B26]). Moreover, the transcripts of *LsCGT1*, *LsNAGA1*, *LsSGPP*, *LsSMPD4*, *LsSMS*, and *LsSPT* were elevated in most stages of viruliferous *L. striatellus* compared with the non-viruliferous *L. striatellus*, suggesting that RSV infection may induce the expression of these six genes. It has been shown that suppressing SPT expression can inhibit HCV replication ([@iew111-B11]), so we predicted that the increase in the expression of *LsSPT* may have a role in facilitating *L. striatellus* infection by RSV. As SMPD4 activation has been implicated in facilitating measles virus to infect cells ([@iew111-B20]), it is possible that the increased expression of *LsSMPD4*period has ended, the nine month rule would be without effect, and there would be no effective limitation period."  United Sand & Gravel, 624 F.2d at 736;  see also Barrett Treaty Ltd. v. United States, 624 F.Supp. 166, 168 (E.D.N.Y.1985);  American Honda, 363 F.Supp. at 991.   Thus, the statutory extension is not applicable because Williams' administrative claim was submitted to the IRS more than nine months after the IRS levied upon the money.   Furthermore, even if the administrative request in this case was timely filed, section 6532(c) would only extend the limitations period to April 1989, five months before this action was filed.

12
Finally, Williams argues that, by issuing to him a Notice of Disallowance which provided that a taxpayer has two


is the nearest to -3 in 1, 589, 1/3, 2/3, -0.3?
-0.3
What is the closest to 7 in 0.5, -0.4, 3, 2, 2/11?
3
Which is the nearest to -2?  (a) -5  (b) 6  (c) 0.1  (d) -0.2  (e) 0.2
d
What is the closest to 0.2 in -1/45, -1, -1/5?
-1/45
What is the closest to 0 in 0.2, 2/9, 5849?
0.2
Which is the closest to 0.2?  (a) -4.3  (b) -3/8  (c) 43
b
What is the closest to -2/7 in 5, 9/589, -2/7, 1?
-2/7
What is the nearest to -5 in -27.65, -6, -1/5, -3, -0.5?
-6
What is the closest to -1/3 in 3, 5, -434?
3
Which is the nearest to -1/6?  (a) -2  (b) -9  (c) -0.3  (d) -111  (e) -2/7
e
Which is the nearest tothe drain -- and he he doesn't want to be part of that spiral downward. And so, you take it for what it is. You take his words at face value and I think common sense tells you what that means.

Q: The administration has maintained that the mayor is moving the city forward on development and other fronts. In what says is he suggesting that Pittsburgh is perishing for lack of vision? Are there some examples that he would point to?

A: Well, again, I would point you to the widely published articles in various print media, where we are reading about contracts being awarded to entities where contributions have been made to the mayor. This is not the way government is supposed to operate. And this is not


Presence of a slow dimerization equilibrium on the thermal unfolding of the 205-316 thermolysin fragment at neutral pH.
Differential scanning calorimetry and size-exclusion chromatography have been used to characterize the dimerization and unfolding of the 205-316 C-terminal fragment of thermolysin at pH 7.5. We show that the folded fragment dimerizes at low temperature with a moderate affinity and undergoes thermal unfolding according to a N(2) <==> 2N <==> 2U model. This behavior has already been observed at acid pH, where a similar dissociation equilibrium has been found [Azuaga, A., Conejero-Lara, F., Rivas G., De Filippis, V., Fontana A., & Mateo, P. L. (1995) Biochim. Biophys. Acta 1252, 95-102]. Nevertheless, at pH 7.5 the dimerization equilibrium slows down below about 30 degrees C, with virtually no interconversion between the monomeric    self.format_str = "%(lvl)s:\t%(msg)s"
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in what supplier and manufacturers do in terms of repairability
of their products. The small scale consumer such as us would then then benefit
from this.

It effect, the mentality of not repairing items has a number of interconnected
causes that feed the problem, from the basic tax law and attitudes of
accountants "protecting" the bottom line, to companies using this attitude to
make it cheaper to not design products that are repairable, to patent law and
copyright law, to that simple staple called greed and the other stable called
politics.

~~~
linuxftw
I've witnessed same effect in the US Military. The problem is, and always was,
they're spending other people's money. They don't need to make the best long-
term decision, they need to make the 'what fits in my budget this quarter'
decision.

------
danans
> The discipline’s most prominent statistic, gdp, iscapable thanks to developing
and fielding cutting edge weapons technology.

It is actually capable because it is extremely effective at logistics and
maintenance.

~~~
madeuptempacct
I think that's very subjective. The USSR actually led the way on some
innovation:

* IRST on MIG-29 and helmet-targeting for infrared missiles

* Titanium welding for high-speed submarines

* Super-cavitating torpedoes

* Stealth theory

* Air dropped vehicles

* Urban tank support vehicles (BMPT)

* Radar targeting for individual machine guns

* CIWS

* Reactive armor

* Lots of other stuff I can't think of right now.

It's also questionable whether the US military efficiency over opponents
scales with budget over opponents.

So its both questionable that it leads in innovation and that this leads to
superiority.

~~~
shoo
> It's also questionable whether the US military efficiency over opponents
> scales with budget over opponents

That's a good point. Apparently the US military funding accounts for 36
percent


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    Q:

Naming a column in R

I am fairly new to code so this solution may be simple; however, I could not find the appropriate answer through my searches.
I am using the quantmod package.
I have just downloaded data using the getFX variable. I have assigned it to my global environment.
I want to plot it in ggplot but I am having an issue. It works fine using the plot feature. However, when I try to figure out what the column names are through the str() feature I am only given one column with a title. The date field is blank and the structure says POSIXct[1:1]. How can I title this date column so I can plot it in ggplot?
I have tried the following but have had no luck
JPYchart <- getFX("USD/JPY",


fleeting existence, evaporating due to Hawking radiation after approximately .

Derivation
While opinions vary as to its proper definition, the most common definition of a Planck particle is a particle whose Compton wavelength is equal to its Schwarzschild radius. This sets the relationship:

Thus making the mass of such a particle:

This mass will be  times larger than the Planck mass, making a Planck particle 1.772 times more massive than the Planck unit mass.

Its radius will be the Compton wavelength:

The Planck length  is defined as

Dimensions
Using the above derivations we can substitute the universal constants h, G, and c, and determine physical values for the particle's mass and radius. Assuming this radius represents a sphere of uniform density, we can further determine the particle's volume and density.

See also
Micromean maximum serum concentration (C max) of colistin were found just above the MIC breakpoint at steady states that would most probably lead to suboptimal for killing the bacteria, even at dosages of 3.0 million international units (MIU) i.e., 240 mg of colistimethate sodium (CMS) intravenously every 8 h. These finding stresses to use high loading as well as high maintenance dose of intravenous colistin. It is not only suboptimal plasma concentration of colistin but also poor lung tissue concentration, which has been demonstrated in recent studies, poses major concern in using intravenous colistin. Combination therapy mainly with carbapenems shows synergistic effect. In recent studies, inhaled colistin has been found promising in treatment of lung infection due to MDR gram-negative bacteria. New evidence shows less toxicity than previously


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       Crusade Shattrath choices and your penchant for pirates. Either way, your best friends and favored factions are listed by expansion. This will help you decide who needs a little more kowtowing and which dungeon to run to max out your standing. And hey, don’t be a Stranger.

SOMETHING’S NOT QUITE RIGHT!

If your character isn't being displayed in its full glory on your Profile page, log in to the game, change a piece of gear and log back out. Refresh the Profile page and your character will be waiting for you (this may take a few minutes). If you run into any issues or bugs when using your new Profile page, let us know on the Website Bug Report forum. That way we can keep everything working beautifully.

What Do You


during typing
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                setTimeout(function() {

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\documentclass{article}
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\usepackage{calc}

\newcommand\cellRedBG[1]
  {\cellcolor{red!#1!white}}

\newcommand\cellRedFG[1]
    {\color{red!#1!black}}

\begin{document}
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\begin{tabular}{rrrrl}
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\multicolumn{1}{c}{Sepal.Length}&
\multicolumn{1}{c}{Sepal.Width}&
\multicolumn{1}{c}{Petal.Length}&
\multicolumn{1}{c}{Petal.Width}&
\multicolumn{1}{c}{Species}
\tabularnewline
\hline

     $5.1$&   $3.5$&   $1.4$&   $0.2$&   setosa\tabularnewline
   $4.9$& \cellRedBG{20}   $3.0$&\cellRedFG{75}   $1.4$&   $0.2$&   setosa\tabularnewline
   $4.7$&   $3.2$&   $1.3$&   $0.2$&   setosa\tabularnewline
   $4.6$&   $3.1$&   $1.5$&   $0.2$&   setosa\tabularnewline
  $5.0$&   $3.6$&   $1.4$&   $0.2$&   setosa\tabularnewline
   $5.4$&   $3.9$&   $1.7$&   $0.4$&   setosa\tabularnewline
\hline
\end{tabular}
\end{center}
\end{document}