by *eLife*. Your article has been reviewed by three peer reviewers, one of whom is a member of our Board of Reviewing Editors, and the evaluation has been overseen by Richard Aldrich as the Senior Editor. The reviewers have opted to remain anonymous.

The reviewers have discussed the reviews with one another and the Reviewing Editor has drafted this decision to help you prepare a revised submission.

Summary:

Using hydrogen-deuterium exchange experiment and molecular dynamics simulations, this work investigated and provided important insight into the structural-mechanism of protein translocation by SecA. The finding is consistent with the previously proposed Brownian ratchet mechanism in showing channel-opening of SecY and simultaneous channel-tightening of SecA upon ATP binding of the latter.

Essential revisions:

While the reviewers were satisfied with the quality of the data and foundproblem is that before I use the unmountComponentAtNode method, the React devtools showed that 300 components were added on each rerender. So, I had 3000 components at some time and growing, despite their underlying (real DOM) DIVs where deleted by the window.map.carsLayerGroup.clearLayers(); method.
So:

Shouldn't the removal of the DOM "DIVs" (by an external library) also automatically "unmount" the related mounted components? Is there a way to do so?
If not, is there a way to unmount all 300+ Car components alltogether without looping? For example, something like React.unmountComponents("Car"). Because my loop is not full-proof: when I retrieve new data, some old items will still remain mounted because they do not appear in the new list that will be looped for unmounting.
Any ideas on how to approach this? The (non-react) DOM


The Molecular Biology and Animal Core will provide reagents to assist in the study of nuclear calcium signaling and its effects in liver. The core will generate, purify and maintain adenoviruses and genetically engineered cell lines in which nuclear or cytosolic calcium signaling is suppressed. The core also will assist in the development and characterization of siRNAs requested for use in the individual projects. The core will offer breeding and genotyping services for MKP-1 knock-out mice. The core will provide hepatocytes and other cells from MKP-1 knock-out mice for the analysis of calcium signaling and related studies. The core will include dedicated personnel and will be located within the Core Directors' laboratory.eventually stops selling the energy drinks, it would be going a step further than other campuses that have banned alcoholic versions. University officials said Monday they were unaware of other colleges having taken the same step, though at least one other school – Mount St. Mary's College in Los Angeles – has a policy of not selling energy drinks in its dining halls. It does sell them from vending machines.

Rick MacDonald, assistant director of UNH dining, said earlier Monday that the decision was in keeping with Huddleston's goal to make UNH the healthiest campus in the country by 2020.

"This is one of many steps we have taken and will take in accomplishing that goal," he said.

Energy drinks typically contain more caffeine than soft drinks, along with large amounts


I’ve been perusing through Yahoo answers and it seems like every page or so someone is asking “What do Hindus believe?” Quite an enormous question!

I tried to find a post of mine to direct the questioners to, but found nothing. It seems I have not done a broad overview post for those entirely unfamiliar with Hinduism.

So here it is: the big overview…

What is Hinduism and What Do Hindus Believe

First of all, Hinduism is a word that is used to refer to a vast variety of people and beliefs. Many say that the word originated as a way for the British to classify the practices of the people they met when they invaded India. In fact, many Hindus today prefer the term Sanatana Dharma, which means the Eternal Balance/Way/Truth/Paththe order relationships coded in the hippocampus, the activity of each cell is projected onto the same corresponding region, so the projected location of the PF on the environment will be allocentric. In “morphing” environments, if the same configuration is projected onto a deformed arena, it creates the effect of the “moving” PF for an external observer.

If the geometric (or in some cases non-geometric [@Muller1; @Muller2; @Muller3]) transformation is a superposition of several dilations or homothetic transformations, there appear to be different groups of cells that follow a particular component of the deformation, thus forming a particular “reference frame” [@Gothard2]. In the experiment [@Gothard2] in which the walls of the environment were rotating while the floor and some objects scattered on it were static (or vice versa [@Muller1;


changes, strongly suggest that PC activity should always be considered in the context of the global state of the network and collective behavior of the PFs. Interesting evidence is provided by the observation of replays of the correct (direct or reversed) sequences of PCs in wake [@Foster] and asleep [@Louie; @Skaggs; @Wilson1] animals, which reflect the pattern of the same cells during actual spatial navigation. This result shows that correct PF sequences can be pinged by the system which remains in a state mapping state during animal’s sleep.

An important support for functional connectivity between PCs comes from the phenomenon of prospective coding, found in [@Frank2]. In this experiment a rat was running on the “W-track” alternating the left and the right turns on its outbound journeys from themiddle to the side arms.

![A schematic representation of the activity of a CA1 place cell showing prospective coding on a W track [@Frank1].[]{data-label="prospective"}](prospret.eps)

Interestingly, a cell with the PF located at the spot where the left and the right trajectories split, was active only if the rat was going to turn to the right, and the same cell would be silent at the same spot, if the rat’s intention was to turn to the left. Such behavior indicates that PCs are not just “place” cells, but rather cells that code for a place in a particular spatial and sequential context, so some larger scale connections are involved in these cells’ activity [@Battaglia; @Ferbinteanu; @Mehta; @Muller4].

Since deformations of the linear tracks do not cause remapping of the PFs, it is


relationships between the neighborhoods of $X$. In the SRE context the topological space in question is the environment $S$ as verified directly by the observer, and in the ISRE case it is the topological skeleton of the hypothetical “inner space” $\tilde{S}$ in which the animal perceives itself, so the ISRE observer in effect induces the structure of the “inner PFs” covering the inner space of the animal from the activity of PCs.

In both cases the analysis of the encoded space is based on the fact that the topological properties of a space can be deduced from the properties of its coverings by open sets $U_{i}$ (neighborhoods) defined either directly or via some additional structures, associated consistently with the neighborhoods. Such analysis allows the topology of the space to$\delta $ [@Novikov; @Swan; @Hirzebruch]. The resulting algebraic structure defines the set of topological invariants that uniquely characterize the topology of the simplex – the Čech cohomologies of the covering, $H^{q}\left( N\left\{ U_{i}\right\} \right) $.

If additional PFs are observed in (I)SRE, the old nerve of the covering will be inscribed into the new one, $\varphi_{UV}:N\left\{ U_{q}\right\}
\rightarrow N\left\{ V_{p}\right\} $, so the refinement of the simplex induces a mapping of the topological indexes $$\varphi_{UV}^{\ast}:H^{q}\left( N\left\{ U_{i}\right\} ,F\right)
\rightarrow H^{q}\left( N\left\{ V_{i}\right\},F\right).$$ Such analysis allows the topology of the environment to be characterized using nonequivalent (in the sense of the Section \[section:remappings\]) coverings that are generated during the remappings. If both new and old coverings are defined via singly connected, contractible in the topology of $X$ PFs, they define the nerve


(inverse of [TPP]{}), [NTPPi]{} (inverse of [NTPP]{}) and [EQ]{}.

![RCC8 relationships.[]{data-label="rcc8"}](rcc8.eps)

Axioms can be introduced to define regions corresponding to the complement of a region, the sum, the difference and the product of a pair of regions – in the cases when they can [*logically*]{} exist.

Interestingly, these RCC relationships are also manifested at a cognitive level [@Knauff; @Renz]. In each PF layout, every pair of PFs can be related to one another via one of the JEPD relationships from a chosen RCC calculus, based on the analysis of the PC firing rates. The regions inferred via RCC Boolean functions may or may not be realized as actual PFs, however [*logically*]{} they are available for spatial reasoning both to the (I)SRE observer and to the animal, and hence they help thepossible directions, but not in the other.

5.  The peak firing frequency (about $20$ Hz) of a particular cell $c$ is reached when a rat passes through the center of its $PF_{c}$, however peak firing rates may differ from cell to cell and for a given cell from environment to environment. Outside of its PF the cell shows only some weak “background noise activity” (about $0.1$ Hz). The averaged spatial firing frequency (the firing probability) of a PC as a function of the coordinates $x$ and $y$ produces a surface that often looks like and usually is modeled as a Gaussian hump over a compact base. As long as the rat remains in the same location, the activity level of the PC remains approximately constant [@Best1].

6.  A


given environment is a very flexible dynamical process with many parameters.

10. \[partition\] The pattern of the positions of PCs in the brain tissue (i.e. in the CA1 or the CA3 areas) does not correspond to the spatial pattern of the PFs in the environment. In particular, neighboring cells do not in general map to neighboring physical places. For example, the PFs of a group of nearby cells recorded from a single electrode are scattered all over the environment. In this sense, the PF mapping of the environment to the cells of the hippocampus is not “topographical”. If parts of two place fields $PF_{c_{1}}$ and $PF_{c_{2}}$ overlap, it does not mean that one cell can “activate” the other. If the rat enters $PF_{c_{1}}$ and has not yet entered $PF_{c_{2}}$,Reflections on Him and His Research, Contemporary Mathematics 39, 1–32, Amer. Math. Soc., Providence RI (1985).

E. Bishop and D. Bridges, [*Constructive Analysis*]{}, Grundlehren der Math. Wissenschaften 279, Springer–Verlag, Heidelberg (1985).

T. Bittner and J. G. Stell, [*Stratified Rough Sets and Vagueness*]{}, Lecture Notes in Computer Science, Vol. 2825, pp. 286-303 (2003).

T. Bittner and J. G. Stell, [*Vagueness and Rough Location*]{}, GeoInformatica, Vol. 6, pp. 99-121 (2002).

T. Bliss and G. Collingridge, [*A synaptic model of memory: longterm potentiation in the hippocampus*]{}, Nature, Vol. 361, pp. 31–39 (1993).

K. Blum and L. Abbott, [*A model of spatial map formation in the hippocampus of the rat*]{}, Neural Comp. Vol. 8, pp. 85-93 (1996).

F. Borceux, [*Handbook of Categorical Algebra III*]{}, Vol. 52 of Encyclopedia of Mathematics and its Applications. Cambridge University Press (1994).

N. Bourbaki,


pp. 123–131 (1994).

A. G. Cohn, B. Bennett, J. M. Gooday and N. Gotts, [ *RCC: a calculus for Region based Qualitative Spatial Reasoning*]{}, GeoInformatica, Vol. 1, pp. 275-316 (1997).

A. G. Cohn and S. M. Hazarika, [*Qualitative Spatial Representation and Reasoning: An Overview*]{}, Fundamenta Informaticae, 46 (1-2), pp. 1-29 (2001).

A. G. Cohn and N. M. Gotts, [*The ‘Egg-Yolk’ representation of regions with indeterminate boundaries*]{}, Proceedings, GISDATA Specialist Meeting on Geographical Objects with Undetermined Boundaries, edited by P. Burrough and A. Frank, pp. 171-187, Francis Taylor (1996).

A. G. Cohn, B. Bennett, J. Goodday, and N. Gotts, [ *Qualitative spatial representation and reasoning with the region connection calculus*]{}, GeoInformatica, Vol. 1(3), pp. 1–44 (1997).

A. G. Cohn and N. M. Gotts, [*Representing Spatial Vagueness: a mereological approach*]{}, Proceedings of the 5th conferenceComputer Science, pages 193-206 (1997).

J. Knierim, B. McNaughton and G. Poe [ *Three-dimensional spatial selectivity of hippocampal neurons during space flight*]{}, Nature Neurosci. Vol. 3, pp. 209-210 (2000).

T. De Laguna, [*Point, line and surface as set of solids* ]{}, Journal of Philosophy, Vol. 19, pp. 449–461 (1922).

P. Lavenex and D. Amaral, [*Hippocampal-Neocortical Interaction: A Hierarchy of Associativity*]{}, Hippocampus, Vol. 10, pp. 420–430 (2000).

I. Lee, A. Griffin, E. Zilli, H. Eichenbaum and M. Hasselmo, [*Gradual translocation of spatial correlates of neuronal firing in the hippocampus towards prospective reward locations*]{}, Neuron, Vol. 51, pp. 639-650, (2006).

F. Lehmann and A. G. Cohn, [*The {EGG/YOLK} Reliability Hierarchy: Semantic Data Integration Using Sorts with Prototypes*]{} , Proc. Conf. on Information Knowledge Management, ACM Press, pp. 272-279 (1994).

C. Lever, N. Burgess, F. Cacucci, T.


category. In S-modules the category of modules over an -operad and the category of monoids are Quillen equivalent and likewise the category of modules over an -operad and the category of commutative monoids. Therefore, is it possible to define -ring spectra and -ring spectra as (commutative) monoids in the category of S-modules, so called (commutative) S-algebras. Since (commutative) monoids are easier to deal with than algebras over complicated operads, this new approach is for many purposes more convenient. It should, however, be noted that the actual construction of the category of S-modules is technically quite complicated.

Diagram spectra
Another approach to the goal of seeing highly structured ring spectra as monoids in a suitable category of spectra are categories of diagram spectra. Probably the most famous one of these isof radiation-induced cardiovascular damage ([@B6], [@B12], [@B13]). Early diagnosis seems to be important to decrease long-term damage, reduce incidence of fatal cardiovascular adverse events and improve quality of life in cancer survivors.

But not only late-time effects are important. An association between higher values of heart dosimetric variables and a worse overall survival at a median follow-up of 2 years was described, suggesting that radiation to the heart could contribute to early mortality in a non-small cell lung cancer population ([@B14]). Especially lung cancer patients are also more likely to have pre-existing risk factors such as known cardiac diseases ([@B15]) and smoking history that may predispose them to cardiovascular events occurring at earlier time points than would be seen in a healthier patient population treated with thoracic radiation therapy


to task (Loffing et al., [@B26]), sex (Gilbert and Wysocki, [@B14]), geography (Perelle and Ehrman, [@B41]), culture, or religion (Fagard and Dahmen, [@B10]; Faurie et al., [@B11]), only about 10--12% of the normal population are estimated to be left-handed (Llaurens et al., [@B19]). In sports, left-handedness is also rarer than right-handedness (Grouios, [@B16]; Loffing and Hagemann, [@B21]). However, compared to the normal population estimate, a higher prevalence of left-handedness has been reported at the elite level of interactive sports such as in cricket for bowling (Edwards and Beaton, [@B9]) and batting (Brooks et al., [@B4]), in baseball for pitching and hitting (Goldstein and Young, [@B15]), table tennis (Raymond et al., [@B42]), fencing (Azémar et al., [@B1]) or tennis (Loffing et al., [@B24]), suggesting that left-handed athletes might havedifferences in gaze behavior as a function of an opponent\'s handedness. We included two differently skilled groups into the protocol to verify that our experiment was capable of capturing components of handball-specific perceptual-cognitive expertise (Mann et al., [@B30]).

![**(A)** Screenshot of the final frame of a video in original and horizontally mirrored orientation. **(B)** Mean prediction accuracy against a right- (RH) vs. left-handed (LH) version of an otherwise identical penalty (i.e., 16 different videos) separately for corner, side and height predictions in goalkeepers (GK; ▴) and non-goalkeepers (Non-GK; ○). Symbols below the diagonal dotted blue line represent penalties where predictions were better against a right- than left-handed version (and *vice versa*). Red dotted lines indicate chance level for right- (vertical lines) and left-handed penalties (horizontal lines). Symbols toward the


merged if a fixation\'s duration was below that threshold and if the distance between the two fixations was within 1°.

Following the creation of a fixation report, the data was further prepared for later analyses. First, for each trial\'s final fixation, recorded fixation offset was checked whether it was beyond the end of a video. This was necessary to ensure that the sum of individual fixation durations in a trial did not exceed the duration of a video shown in that trial. For almost any trial (99.88% of 2432 trials), the end time of such fixation was replaced with the value for video duration in the respective trial. Then, fixation duration was recalculated as the time difference between fixation onset and the new fixation offset and it was checkedif that difference was larger than the fixation duration threshold of 120 ms. If not, that particular fixation was excluded from all further analyses (which happened in 15.63% of all trials), the fixation listed before was newly classified as the final fixation and the number of fixations for such trial was corrected accordingly (i.e., minus one). Second, the offset values recorded during drift check prior to each trial separately for the left and right eye were used to correct raw gaze data by subtracting offset values from raw data. On rare occasions (2.26% out of 2432 trials) these offset values indicated deviation from the screen\'s center larger than 2° and data of those trials were excluded from the analyses later on[^1^](#fn0001){ref-type="fn"}. Third, for each fixation where data for


to anticipate than right-handed action outcomes. Such handedness effect in accuracy, however, was not paralleled by distinct handedness-dependent differences in response time or gaze behavior. With regard to the latter, neither discrete (i.e., number of fixations, overall or final fixation duration) nor dynamic gaze measures (i.e., time-course of horizontal fixation deviations from the center of the screen) varied considerably as a function of a penalty-taker\'s handedness (see the Supplementary Material online for time-courses of mean vertical fixation deviation).

The absence of misalignment in participants\' gaze when viewing left-handed actions (e.g., directing gaze preferentially toward an opponent\'s right body side; Neumaier, [@B37]) seems to conflict with the idea that perceptual asymmetries, which are possibly caused and/or reinforced by the predominance of human right-handedness, may explain lower anticipation accuracy against left-handedto a distance of 4 m away from the goal-line, and often apply this strategy to increase the goal area covered by their body, a penalty-taker\'s height then covers larger visual angle on a goalkeeper\'s retina than we were able to realize with the equipment used in the experiment. Hence, the absence of differences in gaze behavior depending on participants\' skill or penalty-takers\' handedness might be due to the limited size of videos shown. On the other hand, at least for team-handball goalkeeping, inclusion of mobile devices and more realistic life-size projections as well as requiring participants to move must not ultimately result in skill differences in gaze measures (Schorer, [@B44]).

Fourth, we did not control or manipulate the amount of participants\' familiarity with left- vs. right-handed actions. Instead,


In the case of the variable pH, a *Kruskal-Wallis* analysis was run to compare the means to α = 0.0001. The researchers who carried out the evaluation and collected the study outcomes were not aware of the treatments and did not participate in selecting the animals or in data analysis. Likewise, the researcher responsible for analyzing the data gathered was not aware of the treatments. In all tests, a two-tailed *P* \< 0.05 was considered significant.

3. Results {#s0040}
==========

The results of this study show diverse imbalance in gas exchange, the acid-base balance, energy metabolism and the water balance, in all equine groups due to the effect of the time spent in pens at the livestock market. All results were collected in ([Table 1](#t0005){ref-type="table"}, [Table 2](#t0010){ref-type="table"}, [Table 3](#t0015){ref-type="table"}, [Table 4](#t0020){ref-type="table"}, [Table 5](#t0025){ref-type="table"}, [Table 6](#t0030){ref-type="table"},is possible to suggest that the increases in both glucose and lactate could be caused by transport, since before arriving at the livestock market these groups of animals are exposed to different kinds of stressors that cause a high demand for energy. Moreover, the handling procedures performed represent another severe stressor for all these groups, because they tend to be inadequate and so provokes stress, which alters the species' energy metabolism.

The blood pH levels determined for the *charrería* horses, foals, ponies and donkeys were below those found for the cull horses and mules after 5 h of holding in the livestock market. This finding may be attributable to the action of physiological buffers that begin to act immediately by impeding large changes in the concentration of hydrogen ions, as


marginal mandibular nerve and facial vein was preserved. The perifacial nodes and nodes of Level 1B were dissected during this segment and removed with the submandibular gland. The ipsilateral anterior belly of the digastric and mylohyoid were harvested with the flap to help preserve the submental artery and vein which reside between these two muscles. While Level 1A nodal metastasis is uncommon with parotid malignancies, the flap was examined for the presence of palpable or suspicious nodes. In the event one or two nodes were identified they would be meticulously dissected free (none in our series). In the event of bulky nodal disease in Level 1A, the submental flap would not be a suitable reconstructive option.[10](#lio2258-bib-0010){ref-type="ref"}

With the myocutaneous flap freed and attached only by its pedicle, the pedicleof using cadaveric material have been associated with increased infection and seroma risk.[11](#lio2258-bib-0011){ref-type="ref"}

Free tissue transfer is another viable option for reconstruction of this defect. The use of free tissue transfer such as a radial forearm, lateral arm,[5](#lio2258-bib-0005){ref-type="ref"} and anterolateral thigh flap[6](#lio2258-bib-0006){ref-type="ref"}, [7](#lio2258-bib-0007){ref-type="ref"} necessitate a separate surgical site and the associated risks with the respective donor harvest. These techniques also require a longer total operative time.[9](#lio2258-bib-0009){ref-type="ref"}

Several reports have discussed the use of local or regional pedicled flaps which include sternocleidomastoid muscle flaps or the supraclavicular flap. The sternocleidomastoid muscle flap relies on a variable arterial anatomy and also can be associated with postoperative morbidity related to harvesting this muscle. Additionally, the overall defect volume that can be replaced is limited. It however, does not require a separate incision or


1. AC is far away and works too hard2. Water heater needs a “blanket”3. French windows allow heat and air to escape4. Attic insulation has a value of R-95. No floor insulation6. Incandescent lightbulbs waste energy7. Wall insulation has fallen

To be perfectly honest, I’ve never been much more than an armchair environmentalist. Sure, I had some tree-hugging inclinations in college, when I participated in a protest to block the removal of some oaks on the University of Texas at Austin campus (mainly as a way to meet girls, actually). I’ve sent checks to some pompously named organizations like Save the Planet USA now and then, and I’ve been known to have had a barroom argument or two on the subject. But for most of my life, the environmentanswer for my critics, not responding with arrogance but with the message of the gospel, namely that “he saved us, not because of works done by us in righteousness, but according to his own mercy, by the washing of regeneration and renewal of the Holy Spirit” (Titus 3:5).

My kids’ brains desperately need washing, as does mine. My children were born with intrinsic self-absorption that, if left unchallenged, might lead them down dangerous paths, both for themselves and others around them. But Jesus—the Logos, Reason incarnate—is the only one who has ever thought all of God’s thoughts after him in a perfect way. Through his blameless life my kids will know what pleases God, and through his blood their minds can be cleansed. I pray that someday their minds


Padé approximant. It is shown that the minimum gap shifts from $(\pi,\pi)$ to $(\pi,0)$ at $\alpha_{\sbox{cr}}$ which is close to 0.5 for large $\beta$ and grows to 0.576 as $\beta \rightarrow 0$.

At the first glance, these results appear to contradict with the results of the modified spin wave approximation[@ns1; @khfr] which predicts the absence of the spin-gap phase in the single layer model. This method also predicts substantially large critical value of $\beta$. These are due to the underestimation of the quantum fluctuation in the modified spin wave approximation. From this point of view, the present results are consistent with the modified spin wave results[@khfr] if the long range orders found in the latter approximation is reinterpreted as the corresponding short range orders.

Needless to say, the present conclusionthen it is a must see.

As for me I found Big O to be a fun and interesting series because of the nostalgia and the plot that goes from simple to complex in a rather short time span and also manages to confuse me a little. So, if you like a dark hero with a heart of gold mixed with some rather strange characters then The Big O! is for you.

Universal Century 0083. Having triumphed in the One-Year War, the Earth Federation has grown complacent, while the last remnants of Zeon forces have been planning one final stand. It all hinges on ace Zeon pilot Anavel Gato stealing one of the new prototype Gundams out from under the Federation’s nose. With a nuclear-equipped Gundam missing and their pride


between the three. It is not until late in the series that there seems to be a sense of connection. Even with that connection there are plenty of question that are left open.

Overall Grade: B-

As much as I wanted to really like Comet Lucifer and did enjoy some aspects of the series, but all in all I bound it to be forced and overly contrived. The series doesn’t have the feel of Fractle or even the odd the special connection that is found in Last Exile.

I tend to really enjoy these fanciful stories and love the way they tend to unfold. Comet Lucifer has much of the key aspects needed to be a fine series. In the end it does some things really well, but the total developmentuniverse. What I am saying is that I could see myself siding with the Moonrace and wanting to drive out the stupid Earthlings so that someone who would appreciate the earth for what it is could be in control.

Overall Grade: B

Turn a Gundam is a new twist on an old Gundam plot, but it does a good job of telling the story. I just wish the animation was better. By 1999 – 2000 anime productions values had really found a new look and Turn A Gundam held on to some rather tired old artistic values in this series. I get that it is a Gundam series, but for gods sake they should have made it look a lot better than they did.

One other thing that I reality like


    .min(Comparator.comparing(ProList::getRecordNumber))
    .orElse(null);

Now, I have to add functionality for if ProEffectiveDate is null to simply return first row from the list.
When ProEffectiveDate is null, how do I ignore this filter?

A:

Seems like your logic required is to check if any of the ProEffectiveDate is null just return the first element of the list, based on that you could do a check as :
ProList minFilteredRow;
if (proLists.stream().anyMatch(a -> a.getProEffectiveDate() == null)) {
    minFilteredRow = proLists.get(0);
} else {
    minFilteredRow = proLists.stream()
            .filter(filteredRow)
    #include <iostream>
#include <string>
#include <cstdio>
using namespace std;
int main(){
	int c;
	for(;~(c=getchar());)putchar(c==44?10:c);
}


     if($this->input->post("pan") == $ten)
            return true;
        return false;
    } else {
        return false;
    }
}

If you want you can use strtolower(), if case doesnt have any influence in validation. As of now, it will work only for uppercase letters(last 2 characters).

DEBUT ALBUM available now

She's collaborated with everyone from Weezer to Death Cab, and now she's stepping out on her own, combining a love of pop and classical.

The images flicker, the strings swell and swirl, and the vocals of Magik*Magik (a.k.a. Minna Choi) act as a dreamy counterpoint to the Postal Service-esque beat and glitch. (Interestingly her self-titled, Nathan Johnson-produced LP will be released on Chris Walla’s label Trans- on October 14th.)

A few weeks back Choi teased fans with "Laugh a Lot"—her duet with How To Dress Well’s Tom Krell—and below is the premiere of her video for "Circuitry," a mix of animations and projections. It's the soundtrack to some epic rom-com you kinda wish you were the star of.
"When I wrote 'Circuitry I was trying to challenge myself


is, it becomes a little disturbing when a family resemblance develops…

Not everybody could bring their family members, of course. Seinfeld fan Jaime listens to Rob and Akiva with her nine year old daughter, who was not in attendance. This didn’t stop the child from challenging Rob and Akiva to a Seinfeld trivia contest. This may or may not be coming to a Wheel of Podcasts near you…

(Speaking of challenges, Curtis Morrison took on my pyramid puzzle, and entered the league table in second place behind Jeff Pitman, stealing Colin Stone’s spot by a few seconds. Bravo, Curtis!)

I had my own challenge when I ran into Heather Cannon, whom I had inadvertently sub-blogged in the last KIA write up. (I tell you, nobody’s ever happy with their edit.) Luckily,client, the VM may comprise a virtual server that appears and behaves as an actual physical server or desktop for accessing the storage devices. For example, a single physical server may be “virtualized” into 1, 2, 4, 8, or more virtual servers or virtual desktops, each executing their own operating system and one or more applications. A storage system may be configured to allow clients to access its data, for example, to read or write data to the storage system. A client may execute a client application that requests to “connect” to the storage system over a network. The client application may send an access request (e.g., a read request or write request) to the storage system for accessing particular data stored on the storage devices of the


storage system.
A storage system may include multiple VMs. Each VM may be assigned to execute an operating system and one or more applications. For example, a VM may be assigned to execute a storage operating system and typically performs all the storage functions provided by the storage operating system. There are several advantages in implementing storage operating systems within VMs on a physical server. VMs executing the storage operating system may be rapidly cloned and deployed and easily transferred between physical servers in the virtual server environment as needed.
However, a VM executing a storage operating system may be susceptible to failure and only be as reliable as the storage operating system it executes. Also, since the VM typically performs all the storage functions provided by the storage operatingcold.

This practice is unhygienic. It puts the mother and the baby at risk of contracting hygiene-related complications like cholera. It would beyond imagination, breastfeeding your newborn having not taken a shower for a month. Most new mothers no longer follow this practice during their confinement.

Warm ClothingIt didn’t matter whether it was summer or winter. You had to be wrapped up in many pieces of clothing to keep you from cold. It was believed that expectant or nursing mothers could feel the cold even during summer, which was definitely not the case.

Today, women are dropping the outdated practices of confinement. It is vital that you put on clothes that you feel comfortable in. There is a story of a Chinese woman who died from heat stroke during confinement. Putting


solution and a deswelling solution. The lanthionizing solution includes an amount of a lanthionizing agent effective to lanthionize the hair, as discussed above. The deswelling solution includes an amount of reduced malto-oligosaccharide effective to deswell the hair, and preferably includes an acid, such as lactic or citric acid, to neutralize caustic in the lanthionizing composition. Each solution generally includes a suitable solvent, preferably water. The system may be provided in the form of a kit that includes a first container and a second container, the first container including the lanthionizing composition and the second including the deswelling composition. The first and second containers may be contained by or within a third container, such as a package.
Also encompassed by the invention is a method for lanthionizing the hair. Whenthe lanthionizing agent is contained in the same composition as the reduced malto-oligosaccharide, the method includes the step of applying the lanthionizing composition to the hair, waiting for a time effective to lanthionize the hair (typically about 1 minute to two hours, more typically 10-30 minutes) and at least substantially removing the composition from the hair, such as by rinsing. When the system of the invention is employed, the method includes the step of applying the lanthionizing composition., waiting for a period of time effective to lanthionize the composition, and subsequently applying the deswelling composition. The lanthionizing composition may or may not be rinsed before applying the deswelling composition. The deswelling composition may be rinsed from the hair after a period of time effective to deswell the hair,


civicpolitical sense: It is democratic because it rejects the traditional hierarchy of knowledge and replaces it with independent student activity, in which the teacher is merely a partner: 'In such shared activity, the teacher is a learner, and the learner is, without knowing it, a teacher' (p. 174). To be sure, the teacher is not superfluous in this process, as he has to create the conditions in which the student's surroundings appear to her as a challenging problem-not as a trivial hindrance or unsurpassable obstacle, but as a thought-provoking difficulty (pp. 167–171; 1997, pp. 51–60). Yet Dewey's pragmatism, which values thinking according to its usefulness, leads in the final analysis to what Adorno sees as the logic of domination. Although Dewey does not reduce thinking to empty formalthinking and open discussion is prevalent in Anglo-American scholarship on education for thinking, in which active participation in public deliberation is understood as necessary for giving form to thought, for elucidating and refining it (Lipman, 2003). For Adorno, on the other hand, the discursive practice is completely subordinated to instrumental reason and the logic of domination, namely to the attempt to win the argument at any price: [E]verywhere discussion is called for, certainly initially out of an anti-authoritarian impulse. But discussion, which by the way, like the public sphere, is an entirely bourgeois category, has been completely ruined by tactics [ . . . ] Discussion serves manipulation. Every argument, untroubled by the question of whether it is sound, is geared to a purpose [ . . .


closet writing. Essays need to be read, and a certain form of interaction between writers and readers is certainly welcomed by the essay form. An essay written by one student may be read by others and compel them to react, think and write. A school where essays are written thus becomes a special kind of community: Not one of argumentation or discussion but one of writers and readers, a collective of thinkers. Communication in such a community is mediated, and requires time and effort (Heins, 2012, p. 78). It renounces in advance all attempts to persuade, to influence directly. It is what Adorno calls a 'message in a bottle' (Hellings, 2012), sent to the world without knowing in advance who will pick it up and what effects itthe Tsarist Consortium, but her cards keep predicting something even darker and more insidious is ahead. Something that could mean the end, not just for her and Alexei, but for the entire TriSystem — and all of humanity.

Persepolis Rising (The Expanse #7)—James S.A. Corey (December 5, Orbit)
In the thousand-sun network of humanity’s expansion, new colony worlds are struggling to find their way. Every new planet lives on a knife edge between collapse and wonder, and the crew of the aging gunship Rocinante have their hands more than full keeping the fragile peace. In the vast space between Earth and Jupiter, the inner planets and belt have formed a tentative and uncertain alliance still haunted by a history of wars and prejudices. On the lost colony world of Laconia,


Q:

Why does my baby have bubbles around the mouth?

My infant sometimes bubbles from the mouth. When he does this he doesn't seem to be distressed but I end up constantly having to wipe his mouth. Could this be because I am not burping him enough? Does this happen to other people?

A:

Saliva and breathing sometimes can be a recipe for bubbles. It is quite normal.
Take a picture of it when a large one pops up and have  laugh about it with your kid when he grows up.

A:

It happened with my kids.  They were always drooling, bubbling, and dripping with snot.  Slugs are cleaner.

geisha sexploitation films, eventually becoming a staple actress of the studio's "pinky violence" subgenre by the early 1970s.

Selected filmography
 Nude Actress Murder Case: Five Criminals (1957)
 Cannibal Ama (1958)
 Kenpei to yurei (1958)
 Soldiers' Girls (女の防波堤 Onna no bōhatei) (1958)
 Pier of Woman Body (女体棧橋 Nyotai sanbashi) (1958)
 Girl Divers at Spook Mansion (海女の化物屋敷 Ama no bakemono yashiki) (1959)
 Sexy Line (セクシー地帯 Sekushii chitai) (1961)
 Rampaging Dragon of the North (1966)
 Abashiri Prison: Duel in the Wilderness (網走番外地　荒野の対決 Abashiri Bangaichi: Koya no taiketsu) (1966)
 Abashiri Prison: Duel in the South (網走番外地　南国の対決 Abashiri Bangaichi: Nangoku no taiketsu) (1966)
 Abashiri Prison: Duel at 30 Degrees Below Zero (網走番外地　決斗零下３０度 Abashiri Bangaichi: Ketto reika sanjū-do) (1967)
 Abashiri Prison: Fight against Vice (網走番外地　悪への挑戦 Abashiri Bangaichi: Aku e no Chōsen) (1967)
 Blackmail Is


The strategy of the Parti Québécois, if it wins the upcoming Quebec election, is to stage a series of constitutional and financial battles with Ottawa – and use any defeat to help build its case for sovereignty.

With an election expected to be called this week, the PQ refuses to lay out a timetable for a third referendum on sovereignty in the event of a victory. Still, the PQ promises that it would immediately try and whip up popular support – possibly through a referendum on its constitutional demands – in a bid to obtain more powers and money from the federal government.

"I don't see how we can lose," Bernard Drainville, a PQ MNA and lead party spokesman on constitutional issues, said in an interview. "If Quebec wins, ithas been a systematic weakening of Quebec, which has accelerated since the election [last year] of the Harper majority government," Mr. Drainville said.

The PQ accuses the Liberals of failing to launch effective offensives on issues such as Ottawa's decision to pull out of the Kyoto Accord or the dismantling of the long-gun registry, which have faced wide opposition in Quebec.

"Jean Charest is afraid that any defeat would reinforce the sovereigntist movement, so he has decided to remain on his knees and be passive," Mr. Drainville said.

He acknowledged that at times, Mr. Charest has fought back against the Harper government, including on issues such as cuts to cultural programs in 2008. But Mr. Drainville said Mr. Charest's battles with Ottawa are "on and off" and only part of "electoral


groups. The Syrian delegates received a warm, sustained loud applause showing complete solidarity. So did the Palestinian cause, which was at the heart of so many delegates’ speeches.

Bangladesh:

The barbarity of the system was also highlighted by the delegation from Bangladesh. In the weeks leading up to the Congress another factory fire killed over 30 more workers in Bangladesh, less than four years after another fire killed 112 workers. The fight for health and safety was not the only matter being faced by the Bangladesh Trade Union Centre BTUC. New laws are being pushed which will slash labor rights. They returned from the WFTU Congress and immediately organized a large protest against the law.

Brazil:

Brazil had a very large delegation including the Central Workers of Brazil (Central dos Trabalhadores eCyprus sent messages of solidarity to show that she was not alone. Ultimately she was released. (Also in June, a professor was fired on the same charge of insulting the president.)

One of the aims of this state violence is to send a message of not challenging the status quo, not lifting a voice for justice. Union organizing is extremely difficult in this context. And yet it is the courageous aim of the DISK union which sees that only 8 percent of public sector workers and 4 percent of private sector workers are organized and covered by a contract.

The conditions of struggle can be seen in the recent fight by logistics workers to have a union. Mediterranean Shipping Company is the second largest shipping company in the world. It


The meeting was opened by Indonesian Minister of Defense Ryamizard Ryacudu, who has criticized any revision of the anti-communist drive. Rizieq Shihab, a leader of the ultra-right wing Islamic Defenders Front (FPI), gave a slide show presentation on the revival of communism. He denounced the attempts to change education about the 1965 massacre, which up until now portrays PKI members as criminals who tortured people and had to be killed.

Reporters covering the rise of reaction have noted that “since mid-2015 police, soldiers, and vigilantes have broken up dozens of events, from film screenings to meetings of massacre survivors, which have been labeled “communist.”

Organizing a class oriented union in this context is extremely challenging. But KASBI, the Congress Alliance of Indonesian Labor Unions has proven that it is uptheir families. During the summer, new laws were passed that allowed banks to initiate foreclosures and now thousands risk losing their homes.

Privatization of the main public assets is being set for major public institutions like water and electricity airports, highways and ports. Workers will lose jobs and the public will lose services and have less control. All decisions will be based on profit and the people who need these basic services be dammed.

Prime Minister Tsipras has just changed his cabinet to get rid of anyone who has resisted the neoliberal drive against the workers.

Could it get worse? Yes! The IMF and EU “advisors” reviewing labor law believe that the working class must have fewer rights.

They have already forced changes in the law to make it easier to fire


the FTCCP (construction union).

Iran:

Alireza Mahjoub, secretary-general of Workers’ House in Iran spoke about developing workers power in that country. The base of support for class based organizing is partly reflected in the fact that he received over 1.3 million votes in a recent parliamentary election, getting the highest percent of votes in his area of Tehran. The Workers House is the largest trade union center in Iran.

Guadeloupe and Guyana:

A woman representing Guadeloupe spoke to the congress. Guadeloupe has a strong movement. In January 2009, a general strike involving the whole island brought power to the demand for lower prices and only ended when the government agreed to increase the minimum wage and made concessions on other points. This was during the world economic crisis and showed what wasOct. 25 and 26, the Women’s Secretariat of the Sudan Workers Trade Unions Federation (SWTUF) organized a forum of women trade union activists. It brought together 250 women from many of the federation’s unions. The role of women in Sudan’s delegation to the WFTU reflected the organization’s attention to struggle and issues of women workers.

Representatives from dozens of African countries filled the WFTU Congress. Certainly, first and foremost were the delegates from South Africa who shared their struggles, political assessments, and amazing energy with all the other delegations.

Chad:

The general secretary of the Union of Unions of Chad participated in the congress. On Oct. 5 as the congress was opening, a court in Chad issued a ruling against ExxonMobil, ordering it to pay a $74 billion fine for systematically


Tu_i , Tu_i \rangle$ is a number $a$ independent of $i$. Now use the fact that any  vector $u$ can be expanded as $\sum c_iu_i$ to prove i). I leave the details of this last part to you since it is quite routine.

devices (commonly known as interbody spacers, and allograft transplants) as part of the state of the art and routinely employ such devices in the reconstruction of collapsed inter-vertebral disc spaces.
Surgeons insert these intervertebral devices to adjunctively facilitate bone fusion in between and into the contiguous involved vertebrae. This fusion creates a new solid bone mass, which acts to hold the spinal segment at an appropriate biomechanically restored height as well as to stop motion in a segment of the spine in which the patient is experiencing pain. Items surgically placed in these involved interbody regions can thus stimulate interbody bone in-growth such that the operated anterior spinal segments heal into a contiguous bone mass; in other words, a fusion occurs. Further, the surgical community uses such man-made implants


or biological options to provide weight bearing support between adjacent vertebral bodies, and thereby correct or alleviate a variety of mechanically related clinical problems. In this regard, surgeons use intervertebral spinal implants/transplants for surgical therapy for degenerative disc disease (DDD), discogenic low back pain, spondylolisthesis, reconstruction following tumor or infection surgery, and other spine related maladies requiring surgical intervention.
In many implant designs, a relatively hard or sturdy implant construct is formed from a selected biocompatible material such as metal, ceramic, plastic, or carbon fiber-reinforced polymer. This implant construct often has a partially open or porous configuration and is coated or partially filled with a selected bone ingrowth-enhancing substance, such as harvested bone graft supplied from the patient, human donor allograft bone transplant material supplied by a tissue bank,gear is disposed adjacent to, and in meshed threaded communication with, the threaded shaft of the anchoring elements such that rotation of the gear causes rotational torque of the anchoring elements. The driving rotational force on the gear causes the anchoring elements to rotate, deploy from the body, and thread into the vertebral bone of the patient's spine.
Despite the advancements in the art, there is nevertheless a need for a new intervertebral device that includes self-contained anchoring members that deploy in response to rotational, pulling, or pushing driving forces.


Standard fluorescent tubes used throughout the world are generally known as T8 tubes and may be rated at a number of different power values. These fluorescent tubes are gradually being replaced by T5 tubes which also may be rated at a number of different power values but less than a corresponding T8 tube. Such replacement is ongoing in order to reduce energy consumption and thereby minimising greenhouse gas emissions. Consequently, energy costs will also be reduced to business users and residential users. As a result of reducing the power or energy consumption and providing substantially the same illuminance than the existing T8 tubes, the length of the new T5 tubes is shorter than the old T8 tubes. Consequently in order to use the new shorter tubes, corresponding T5fittings need to be purchased and installed which can be extremely expensive for businesses that have large useable floor space where the lighting requirements to illuminate such floor space involves many fluorescent tubes. Not only would a business be expected to pay a large cost for converting to the new tubes but also for the installations and fittings that go with those new tubes.
The present invention seeks to overcome the abovementioned disadvantages by providing a fluorescent tube adaptor that is adapted to enable the use of the new T5 fluorescent tubes in existing T8 fluorescent tube housings or fittings. In this manner much cost will be saved to businesses and consumers in that they avoid having to replace the existing T8 fluorescent tube light fittings with new T5


(29 - 85)*64/(-44). Which is smaller: 80 or l?
80
Let m be -1 + 5 + (0 - -1) + -12. Let z(d) be the third derivative of 3*d**6/40 + d**2. Let w be z(-1). Are m and w unequal?
True
Let l be (-7)/(-2) + (-3)/6. Let u(k) = 9*k**2 - 2*k + 1. Let b be u(1). Suppose -l = 4*q + m, -3*m = -4*q + b*q + 9. Which is greater: 1 or q?
1
Suppose -4*j - 2*d = 38, 0*d = 4*j + 4*d + 44. Let o(p) = p**2 + 4*p. Let h be o(-4). Suppose h = 4*s - 16 + 48. Is s <= j?
True
Let i be -4*(-2177)/98 + 2/14. Which is smaller: i or 86?
86
Suppose 2*p - 139 + 49 = 0. LetIs q < -49?
False
Suppose 3*k + p - 16 = 0, 6*p + 40 = 5*k + p. Which is smaller: 0.177 or k?
0.177
Suppose 0 = 5*d + h + 20, 4*d - 1 - 7 = 4*h. Let k be (-20 - 0)*(-1 - -4)/d. Which is bigger: k or 18?
k
Let n = 4.2 + -25.2. Let p = 0.1729 - 1.1729. Is p greater than or equal to n?
True
Suppose 10*b - 6*b + 24 = 0. Let q be 174/(-21) + (-4)/(-14). Do b and q have the same value?
False
Let n = -52/53 + 1311/742. Let y be 8/(-7)*(-1)/(-4). Let a = n + y. Are a and 8 equal?
False
Let x = -3 - -6. Suppose x*y - 24 = -6. Let b = 14 -


6 = 12 for t.
1
Solve -97*f - 320 = -17*f for f.
-4
Solve 9*y - 6*y - 12 = 0 for y.
4
Solve -7*v = -2*v + 15 for v.
-3
Solve 814*q = 810*q - 4 for q.
-1
Solve 0 = 23*l + 152 - 267 for l.
5
Solve -69*w = -64*w - 20 for w.
4
Solve -38 + 95 = -19*h for h.
-3
Solve -5*v = -18*v + 39 for v.
3
Solve 150 - 165 = -5*y for y.
3
Solve -15339*v + 15325*v = 42 for v.
-3
Solve 0 = -5*f + 15 for f.
3
Solve 0 = -3*j + 10 - 25 for j.
-5
Solve 4 = 4*f - 8 for f.
3
Solve 13*s = 5*s + 8 for s.
1
Solve 0*t + 5*t - 10 = 0 for t.
2
Solve -3*i - 35 + 20 = 0 for i.
-5
Solve 84*nfor safety concerns, and therefore, the drug can be stopped if significant hemolysis occurs. However, because primaquine treatment is usually unsupervised, adherence to such a prolonged course of antimalarials is generally poor, limiting its effectiveness and public health benefit.

The main determinant of primaquine efficacy is the total dose of primaquine administered rather than the duration over which it is delivered.[@R6] Shorter courses with a higher daily dose of primaquine have the potential to improve adherence and thus, effectiveness without compromising efficacy. In Thailand, directly observed primaquine administered over 7 days rather than the same dose over 14 days was well-tolerated and reduced recurrent infections by day 28 to 4%.[@R7] This finding is encouraging, but because many relapses present after 1 month, longer follow-up is needed to distinguish whether


Sánchez.

Play Video 0:59 Mourinho says 'manhunt' against him affecting Manchester United players - video

Dropped again by Mourinho, the Chilean had been a jumble of clumsy touches, over-hit passes and baffling low-confidence after coming on with 23 minutes remaining. But he refused to give up and provided the sweetest of moments when he headed past Martin Dubravka for a memorable winner in the dying seconds.

For Mourinho this was the dream script: an uplifting, backs-to-the-wall victory that illustrated the players possess precisely the spirit required. Lukaku said: “You know we do a lot of stuff together. We are a tight group. Every time a new player comes in we try to make him feel comfortable. And that is the key.

“The dressing room has always been good and that has always    }
        }

        // Return the optimized surface
        return optimizedImage;
    }

    void apply_surface(int x, int y, SDL_Surface* source, SDL_Surface* destination, SDL_Rect* clip = NULL)
    {
        // Holds offsets
        SDL_Rect offset;

        // Get offsets
        offset.x = x;
        offset.y = y;

        // Blit
        SDL_BlitSurface(source, clip, destination, &offset);


 // If the square went too far to the left or right or has collided with the wall
        if (( box.x < 0 ) || ( box.x + SQUARE_WIDTH > SCREEN_WIDTH ) || ( check_collision(box, wall)))
        {
            // Move back
            box.x -= xVel;
        }

        // Move the square up or down
        box.y += yVel;

        // If the square went too far up orFill the screen white
            SDL_FillRect(screen, &screen->clip_rect, SDL_MapRGB(screen->format, 0xFF, 0xFF, 0xFF));

            // Show the wall
            SDL_FillRect (screen, &wall, SDL_MapRGB(screen->format, 0x77, 0x77, 0x77));

            // Show the square on the screen
            mySquare.show();

            // Update the screen
            if (SDL_Flip(screen) == -1)
            {


triggers = set()

        for alarm in [x for x in self.component.subcomponents() if x.name() == "VALARM"]:
            (trigger, related, repeat, duration) = alarm.getTriggerDetails()

            # Handle relative vs absolute triggers
            if isinstance(trigger, DateTime):
                # Absolute trigger
                start = trigger
            else:
             master = None
        overrides = []
        for component in componentSet:
            if component.name() == "VEVENT":
                if component.hasProperty("RECURRENCE-ID"):
                    overrides.append(component)
                else:
                    self._addMasterEventComponent(component, lowerLimit, limit)


   for key in sorted(x for x in self.instances.keys() if x > str(rid)):
                oldinstance = self.instances[key]

                # Do not override instance that is already overridden
                if oldinstance.overridden:
                    continue

                # Determine the start/end of the new instance
           start of the range we want, ignore it
        if lowerLimit is not None and end is not None and end < lowerLimit:
            return

        # Now look at each FREEBUSY property
        for fb in component.properties("FREEBUSY"):
            # Look at each period in the property
            assert isinstance(fb.value(), list), "FREEBUSY property does not contain a list of values: %r" % (fb,)
            for period in fb.value():


Tag: medicinal plants

According to an 8 January 2014 member advisory release by the American Botanical Council (ABC), in Austin, Texas, researchers from the University of Minnesota College of Pharmacy and Masonic Cancer Center reported findings of a study published in the journal Cancer Prevention Research yesterday which found daily consumption of a kava-derived dietary supplement prevented the formation of 99 percent of tumors in a mouse lung tumor model used to predict lung cancer in humans. Positive animal studies usually suggest further research leads, but this study shows such a significant benefit that further development will be accelerated. The levels of success is reported with a patent-pending extract of Kava components, not currently available off-the-shelf Kava dietary supplement products.

A traditional ceremonial beverage of South Pacific societies, Kava (Piperand may lead to a greater emphasis on prevention rather than cure.”

In the January 8th member advisory release, the Austin, Texas-based American Botanical Council, quotes Prof. Bill Gurley PhD, professor of pharmaceutical sciences at the College of Pharmacy of the University of Arkansas for Medical Sciences in Little Rock and a leading expert on herb toxicology. Prof Gurley reviewed the study and commented to ABC, “…the findings are both compelling and certainly merit further research in order to translate them into the clinic. The findings are a breath of fresh air for kava, in particular, and botanical supplements, in general. Recently supplements have suffered quite a bit of negative publicity — some of it deserved, some not — but the kava study from the University of Minnesota emphasizes


genus — the only surviving member of the ancient and primitive ginkgo family—Ginkgoaceae. Ginkgo has been cultivated in East Asia for hundreds of years. Numerous reports mention the existence of large specimens, some more than a thousand years old, at ancient temples in Japan and China. The tree was first introduced to North America in 1784 in the garden of William Hamilton at Woodlands near Philadelphia. Mature ginkgos are said to reach over 100 feet in height. Its longevity as individual trees and a species in general can in part be attributed to its exceptional resistance to pests and resiliency to destruction by fire. It is also extremely tolerant of air pollution thriving in the harshest urban environments.

Ginkgo leaf extracts are highly complex, highly concentrated preparations with ananother group of compounds, ginkgolic acids, which are perceived as potentially toxic, are reduced to below 5 parts per million. Given the specific chemical make-up of ginkgo leaf extracts, it becomes clear why you can’t apply the results of studies with Ginkgo leaf extracts to a simple tea made from ginkgo leaves. Numerous pharmacological and clinical studies on Ginkgo leaf extracts have demonstrated a positive effect in increasing vasodilation and peripheral blood flow rate in capillary vessels and end-arteries in various circulatory disorders, varicose conditions, post-thrombotic syndrome, chronic cerebral vascular insufficiency, short-term memory improvement, cognitive disorders secondary to depression, dementia, tinnitus, vertigo, antioxidant activity, among other effects.


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Bilbao and the Basque Country Hotels

Miró Hotel

A design refuge that places you in the eye of Bilbao's art and architecture fiesta

Cons

Not unpretentious

A hint of preciosity pervades these halls

Updated 03/12/2014

Fodor's Review

Perfectly placed between the Guggenheim and Bilbao's excellent Museo de Bellas Artes, this boutique hotel refurbished by Barcelona fashion designer Toni Miró competes with the reflecting facade of Javier Mariscal's Domine Bilbao just up the street. Comfortable and daringly innovative, it is one of the city's sleek new fleet of hotels inspired by the Guggenheim. The high-tech, contemporary rooms are spacious and lavishly draped in subdued mauves andClarke$^1$\
    $^1$Institute of Astronomy, University of Cambridge, Madingley Road, Cambridge, CB3 0HA, United Kingdom\
bibliography:
- 'references.bib'
date: Written June 2015
title: 'Quantification of stochastic fragmentation of self-gravitating discs'
---

Introduction {#sec:intro}
============

It is widely believed that planets can form via fragmentation of disc gas only in the outermost regions of protoplanetary discs (i.e. $>  50$ A.U.; [@Rafikov2005; @CathieChemFrag; @Rice09]) . This mechanism is thus favoured for explaining planets in wide orbits as detected via direct imaging [@HR8799; @HR8799_2] for which the time to form by the alternative core accretion model is uncomfortably long. Core accretion (i.e. the assembly of a rock core and subsequent accretion of disc gas) is therefore favoured for the formation of the vast majority of gas giant planets detected to date.

The argument against forming planets by


find that the average time any patch of disc spends between spiral wave encounters is broadly consistent with the findings of [@MYfrag] and that the stochastic nature of the disc’s spiral structure can only increase this time by at most a factor of a few.

Consistent with earlier studies [@Cossins1], we find that the distribution of wait times between strong shocks is independent of both resolution and $\beta$. Furthermore, the distribution of wait times decreases exponentially for wait times beyond $\sim 15 t_{dyn}$. Combining this finding with the expected $\beta \propto R^{-9/2}$ scaling of cooling time with radius, we find that stochastic fragmentation is unable to modify the radius at which fragmentation is possible by more than a few 10s of percent. This finding restricts direct collapse as aquasi-likelihood estimator for $\beta$ is given by $$\begin{aligned}
\label{betahat}
        \widehat\beta=\mbox{argmax}_{\beta}\mathcal Q(\beta).
    \end{aligned}$$

The quasi-likelihood estimate of $\beta$ can be obtained by using the `R` package `glm`. To estimate the remaining (nuisance) parameters, we use the moments and autocovariance function obtained in the previous section and then propose a kind of method of moments estimators. This strategy has been used for instance by [@zeger], [@davis2000], [@davis2009] and [@christou2014].

We obtain the standard errors for the quasi-likelihood estimates of $\beta$ through a Monte Carlo simulation. We call attention that we are not assuming a specific distribution for the time series given by the latent process. On the other hand, this is not a problem since it is enough in each Monte Carlo replica


the latent process, the quarterly seasonalities are not significant. This shows the importance of considering a suitable model specification, otherwise inference may be compromised.

[.33]{} ![Histograms of the standardized quasi-likelihood estimate of the $\beta$’s for the precipitation data.[]{data-label="fig_hist_prec"}](hist_prec2.jpeg "fig:"){width="\linewidth"}

[.33]{} ![Histograms of the standardized quasi-likelihood estimate of the $\beta$’s for the precipitation data.[]{data-label="fig_hist_prec"}](hist1_prec2.jpeg "fig:"){width="\linewidth"}

[.33]{} ![Histograms of the standardized quasi-likelihood estimate of the $\beta$’s for the precipitation data.[]{data-label="fig_hist_prec"}](hist2_prec2.jpeg "fig:"){width="\linewidth"}

[.33]{} ![Histograms of the standardized quasi-likelihood estimate of the $\beta$’s for the precipitation data.[]{data-label="fig_hist_prec"}](hist3_prec2.jpeg "fig:"){width="\linewidth"}

[.33]{} ![Histograms of the standardized quasi-likelihood estimate of the $\beta$’s for the precipitation data.[]{data-label="fig_hist_prec"}](hist4_prec2.jpeg "fig:"){width="\linewidth"}

[.33]{} ![Histograms of the standardized quasi-likelihood estimate of the $\beta$’s for the precipitation data.[]{data-label="fig_hist_prec"}](hist5_prec2.jpeg "fig:"){width="\linewidth"}

[.33]{} ![Histograms of the standardized quasi-likelihood estimate of the $\beta$’s for the precipitation data.[]{data-label="fig_hist_prec"}](hist6_prec2.jpeg "fig:"){width="\linewidth"}

[.33]{} ![Histograms of the standardized quasi-likelihood estimate— the international space program."

To the moon

Hadfield said a logical progression would be to include as many countries as possible in an international mission beyond Earth — "hopefully including China and India and the other countries that have launch capability and then progress to the next stepping stone, the next natural waypoint out to space, which is the moon."

Iain Christie, executive vice-president of the Aerospace Industries Association of Canada, says China's presence in space cannot be ignored. The association represents the interests of more than 700 aerospace companies across Canada.

I think China is back where we were in North America 50 years ago. They're excited about space. - Iain Christie, Aerospace Industries Association of Canada

"I think China is back where we were in North America 50 years ago,"


lurked in the woods, she would have found the atmosphere quite lovely.

Swamp | Art by Christine Choi

"We'll sleep in the boat," Vraska said. She let go of the oars and hissed as she poked at one of her blisters.

The thaumatic compass sat on the plank between the two Planeswalkers. Jace picked it up and looked where it was pointing. "That thing would be more useful if it told us how far we had to go," said Vraska as she stretched one arm out, then the other. She laced her fingers together and sighed with relief.

Jace didn't answer.

He looked up, and the magic in his eyes lit up the contours of his face. A large draft horse materialized above them, glowing a delicate blue against the night sky, anddinosaurs crossing it?"

"No, it was cut by dinosaur loggers," Jace explained further in perfect, sarcasm-less deadpan. Vraska snorted a laugh.

Jace shook his head gravely. "Don't insult the noble trade of dinosaur forestry."

Vraska's laugh was interrupted by an odd smell in the air.

A thick cloud of dark smoke suddenly flooded the grove around them.

The smoke was cloying, an inky mist with the vague scent of myrrh that enveloped the trees, obscuring what little light broke through the canopy above and turning day suddenly into night.

Jace shouted in surprise, then reached out to sense what he could with his mind.

Vraska was standing in the center of the path, grappling with a barely-visible foe. The mist was too thick for vision—he reached out to the enemy's mind, sensed the spell that


blood gushing from a wound in his head and his eyes alight with magic. His face was flush with confusion and pain, a faraway look in his eyes.

Did he see it too—?!

"Jace!" she howled, swimming closer, pulling herself and her heavy soggy clothes through the murky water, paddling to stay out of the swift current brought by the waterfall. "Jace, your head—AHH!"

Vraska gasped.

She wore a blue cloak and hood, and lay on the central dais of the Forum of Azor. Niv-Mizzet, the parun of the Izzet, was looking down at her, and she could make out the faces of the maze-runners from every guild of Ravnica. This is a memory, Vraska realized. The memory was colored with meaning, belonging, responsibility. It was the day Jace became the Livingthe attendant ravages of age, was central to my upbringing -- "The oldest hath borne most: we that are young Shall never see so much, nor live so long." She is central still to my moral universe. Her socialistic dictum, that you can only sleep in one bed, the concomitant of which is that those who have more than one bed declare themselves to be embedded in excess, remains core to my worldview. Her degenerative illness manifested itself in many tragic and demeaning ways, but two strange Shakespearian wisdoms arose: she confused family members (I was often thought to be my father, and vice versa); and she disremembered the trivial and the everyday whilst clearly recalling events from 50, 60 and even 70 and more years ago. The


is such a beguiling work because it is a bit all over the place. Sometimes, Shakespeare's poetry takes him so far into the human that he feels timeless, but many aspects of Lear can't help but foreground the Jacobean. The messy nature of the play, however, also underscores something very human -- humans are not neat! Their emotions, their desires, their hopes and fears are messy, ridiculous, unfounded, grandiose, illogical, perverse. Their madness sometimes allows them to see the world's madness, sometimes reflects that madness, and sometimes is merely an awful, lonely, destructive vortex...

A kind of order is restored to Lear's domain at the end of the play. But the order comes at a terrible human cost, and the order is itself contingent: Lear dies, whilst humbled andas well as staging his earliest plays (more...)

Via the Telegraph, "a painting that may be the only surviving portrait of William Shakespeare made in his lifetime" will be unveiled later today:

The picture, from 1610, six years before the playwright's death, has been in the possession of the Cobbe family since the early 18th century.

It was initially kept at a property in Hampshire but more recently in Hatchlands, the family house in Surrey, which is run by the National Trust.

For three centuries the family was unsure of the identity of the figure in the portrait. According to Alec Cobbe, an art restorer, at one time it had been thought to be of Sir Walter Raleigh.

Although the painting has not been proven to be the bard, it has the backing


viable cells. Median, interquartile range (boxes) and range (error bars) of 18 samples. \*\* denotes P=0.02, \*\*\* denotes P\<0.001 in the Wilcoxon signed rank test. **D**. Active Bax was measured by flow cytometry at early timepoints after treatment with TG02 (pale grey squares) or ABT-199 (dark grey diamonds) (Mean + standard deviation for 4 samples). Cytotoxicity at 16-20 hours (marked 18 on the X axis) is also shown.](oncotarget-08-16220-g005){#F5}

It might be argued that the effects of apoptosis-inducing agents should be studied at high concentrations in order to document their abilities to eradicate the cells, so we also treated 18 primary samples with the higher concentrations of 50 nM TG02 + 50 nM ABT-199 or 100 nM of the 2 agents individually. We showed that using either agent at 100UK distributor Alere (Stockport, UK). For Western blotting, rabbit polyclonal MCL-1 (S-19) (sc-819), mouse monoclonal BCL-2 (C-2) (sc-7382), goat anti-rabbit IgG-HRP (sc-2054) and goat anti-mouse IgG-HRP (sc-2055), were all obtained from Santa Cruz UK supplier Insight Biotechnology, Wembley). CD2 Dynabeads were from Invitrogen (Paisley, UK). z-VAD-fmk was from Calbiochem, Nottingham, UK. Additional reagents were obtained from Sigma (Poole, UK) unless otherwise stated.

Cell lines and culture {#s4_4}
----------------------

The OCI-AML3 myeloid leukemia cell line was obtained from the German Collection of Microorganisms and Cell Cultures (DSMZ, Braunschweig, Germany). The KG-1a cell line was from the European Collection of Animal Cell Cultures (Salisbury, UK). The MV4.11 cell line was from the American Tissue Culture Collection (Manassas, USA). OCI-AML3 and MV4.11 cell lines were maintained in R10 medium and KG-1a cells in R20


medium (i.e. RPMI 1640 medium with 10% (R10) or 20% (R20) foetal calf serum (FCS; First Link, Birmingham, UK), and 2mM L-glutamine. All cultures were kept at 37°C in 5% CO~2~ and all experiments were performed with cell lines in log phase. Continued testing to authenticate these cell lines was performed using multiplex short tandem repeat analysis (Powerplex 16, Promega, Southampton, UK). Mycoplasma testing was carried out routinely using the Mycoalert mycoplasma detection kit (Lonza, Rockland, USA) and following the manufacturer\'s instructions.

Cell line toxicity assays {#s4_5}
-------------------------

Cells were set up at 5 X 10^5^/ml and cultured in R10 or R20 (see above) for 18-22 hours. Toxicity was measured using Alamar Blue (Roche, Mannheim Germany) according to manufacturers' instructions.

Patient cell toxicity assays {#s4_6}
----------------------------

Cells were cultured for 18-22 hours in R10downstream over the stubhorn. The can bodies are moved longitudinally over the stubhorn from a magazine by suitable conveyor means such as lugs of a chain conveyor which engage the rear edge of the can bodies and push the can bodies along the stubhorn or a magnetic conveyor wherein moving belts carrying magnets engage the metal cans to move them along the stubhorn. In the final stages of the movement of the can bodies over the stubhorn, the ends of the sheet metal are brought together and joined. The bodies are seamed together by a weld at a welding station. As the bodies pass off the stubhorn and onto rails, they are pushed through an inside striping station. At this station, a stripe of protective material is sprayed


Abdelmawgoud, A., Brown, C. J., Sui, X., Fonarow, G. C., Kokkinos, P. F., Bittner, V., Aronow, W. S., Kheirbek, R. E., Fletcher, R. D., Blair, S. N., and Ahmed, A. (2015), Relationship of physical activity and healthy eating with mortality and incident heart failure among community‐dwelling older adults with normal body mass index. ESC Heart Failure, 2: 20--24. doi: [10.1002/ehf2.12028](10.1002/ehf2.12028).27499885

Normal body mass index (BMI) has been shown to be associated with lower mortality and incident cardiovascular (CV) events.[1](#ehf212028-bib-0001){ref-type="ref"}, [2](#ehf212028-bib-0002){ref-type="ref"}, [3](#ehf212028-bib-0003){ref-type="ref"}, [4](#ehf212028-bib-0004){ref-type="ref"}, [5](#ehf212028-bib-0005){ref-type="ref"} Normal BMI maybe achieved by physical activity (PA), healthy eating (HE), or both.[6](#ehf212028-bib-0006){ref-type="ref"} However, it is unclear which has a stronger association with lower mortality. In the current analysis, we examined the association of PA and HE with mortality and incident heart failure (HF) among older 227 (45%)      0.084
  Alcohol, drinks per week                   2.6 (±7)       3.1 (±7)       2.7 (±7)       2.6 (±7)       0.837
  Smoke, pack‐years                          19 (±28)       19 (±28)       15(±28)        17 (±28)       0.026
  Never


  0.20 (±1)      \<0.001
  Blocks walked last week                    18.80 (±59)    21.58 (±59)    50.09 (±59)    52.52 (±59)    \<0.001
  Time to walk 15 ft                         6.9 (±3.3)     5.9 (±2.2)     5.5 (±1.6)     5.4 (±1.5)     \<0.001
  Mini‐mental state examination score        27 (±3)      1.00 (Reference)
  PA--/HE+ (n=152)   24% (37)             1.16 (0.78--1.73); p=0.458       1.21 (0.81--1.80); p=0.351                               1.26 (0.84--1.89); p=0.266
  PA+/HE-- (n=961)   17% (164)            0.67 (0.51--0.89); p=0.005       0.71 (0.54--0.94); p=0.017                               0.92


as reliable as self‐reports of PA, which may potentially explain the lack of association of HE with better outcomes. Also, in our study, the prevalence of coronary artery disease was lower in the PA group than in the HE group. If one assumes that both PA and HE preceded baseline coronary artery disease, then one might conclude that the beneficial health effect of PA was stronger than that of HE. However, no such correlation was observed for diabetes, the incidence of which may also be affected by PA and HE. In contrast, we observed that the prevalence of chronic obstructive pulmonary disease, the incidence of which is not known to be affected by PA or HE, varied across PA and HE subgroups, suggesting that baseline chronic obstructive pulmonarydisease had a more profound impact on PA than on HE.

Another potential explanation is that health benefits of HE maybe attenuated among older adults as prior studies demonstrating associations of PA and HE with lower mortality and cardiovascular events were based on children and younger adults.[1](#ehf212028-bib-0001){ref-type="ref"}, [2](#ehf212028-bib-0002){ref-type="ref"}, [3](#ehf212028-bib-0003){ref-type="ref"}, [4](#ehf212028-bib-0004){ref-type="ref"}, [5](#ehf212028-bib-0005){ref-type="ref"}, [14](#ehf212028-bib-0014){ref-type="ref"}, [15](#ehf212028-bib-0015){ref-type="ref"}, [16](#ehf212028-bib-0016){ref-type="ref"}, [17](#ehf212028-bib-0017){ref-type="ref"}, [18](#ehf212028-bib-0018){ref-type="ref"} For example, findings from the United States National Health and Nutrition Examination Survey 2003--06 suggest that PA and HE were associated with lower cardiovascular biomarkers.[14](#ehf212028-bib-0014){ref-type="ref"} However, participants in that study were children 6--17 years, and the authors of that study used a more comprehensive Healthy Eating Index, a measure of diet quality in terms of conformance to United States federal dietary guidance. Similarly, the Indonesia Nutrition and Health Surveillance System study suggesting an association


of fruits and vegetable consumption with lower odds of mortality was based on children under the age of 5 years.[15](#ehf212028-bib-0015){ref-type="ref"} In contrast, the Finnish Kuopio Ischemic Heart Disease Risk Factor study that demonstrated an association between high fruit and vegetable intake and lower risk of mortality was among middle‐aged (mean age, 53 years) men. Findings from a study of patients with apparent treatment‐resistant hypertension (mean age, 67 years) also have suggested that higher PA may have stronger association with lower risk for cardiovascular events and mortality than dietary factors such as moderate alcohol consumption, high Dietary Approaches to Stop Hypertension diet score, and low sodium‐to‐potassium intake ratio.[19](#ehf212028-bib-0019){ref-type="ref"} In contrast to these studies, CHS participants were older (mean age, 75 years), and in addition, participants in our study had a normal BMI. Althoughpackage com.eptison.eop.datasources;

import org.springframework.jdbc.datasource.lookup.AbstractRoutingDataSource;

import javax.sql.DataSource;
import java.util.Map;

/**
 * 动态数据源
 */
public class DynamicDataSource extends AbstractRoutingDataSource {
    private static final ThreadLocal<String> contextHolder = new ThreadLocal<>();

    public DynamicDataSource(DataSource defaultTargetDataSource, Map<Object, Object> targetDataSources) {
        super.setDefaultTargetDataSource(defaultTargetDataSource);
        super.setTargetDataSources(targetDataSources);
        super.afterPropertiesSet();
    }

    @Override
    protected Object determineCurrentLookupKey() {
        return getDataSource();
    }

    public static void setDataSource(String dataSource) {
        contextHolder.set(dataSource);
    }

    public static String getDataSource() {
        return contextHolder.get();
    }


payments to help cover their needs through these prescription assistance networks. You can count of these prescription assistance networks from private companies and groups that can provide these for people who are in need. It is important that you can learn about these prescription assistance networks so you can take them for your own benefits and make an informed choice for all your needs and your goals. These kinds of prescription assistance networks are being able to provide an increasing number of people with the road towards the healing process through the medicines that will be part of the progam. The ability to take such actions can produce fantastic effects.The Essential Laws of Medicines Explained
There are sometimes challenges when it comes to the resources that provide information aboutasthma, diabetes and more. Aside from adults, even teenagers and children can benefit from these prescription assistance programs for all their various needs in their daily lives. These prescription assistance programs can offer people with financial aid if you need to qualify for a medicine program by agencies around you. Many of these prescription assistance programs can be accessible through the internet or you can ask your physicians about these. There are certain approaches that these prescription assistance programs can offer you as advantages.


been inching along," he told CBC's Information Morning Cape Breton.

MacLellan said it's been an eye-opener to see how many people are impacted by this issue.

In May, government officials announced a $26.4-million plan, most of it federally funded, to bring high-speed internet access to 64 rural and remote communities in Nova Scotia.

MacLellan said the cost to ensure that all Nova Scotians have access to high-speed internet is estimated at $300 to 500 million.Gary Whitta (Book of Eli) is writing the script for the movie, which has a release date set for December 16, 2016, said Disney and Lucasfilm in a statement later posted on the official Star Wars website.

Due to the high level of secrecy surrounding the Star Wars development process, it is unclear which spinoff Edwards will tackle.

Speculation has focused on characters such as bounty hunter Boba Fett and Jedi master Yoda as those who might be getting their own movies. There are also rumors of a potential Han Solo origin story or at least something on the Solo clan, and untold adventures of Luke Skywalker.

"Ever since I saw Star Wars I knew exactly what I wanted to do for the rest of my life - join the Rebel


Q:

Generate a data entry form dynamically from XSD including validation rules

Is there anything around that can read an XSD schema and dynamically create a (Windows C#) data entry form? It would also need to read the type definitions and use them to validate the data entered. The data would then be save as an XML file.
I would prefer it was a dynamic form since the XSD could, and probably will change. I'd rather not have to rebuild and redistribute the app every time it changes.
I have seen XSD2code which looks promising but doesn't seem to be dynamic.
The XML data editor on Codeplex looks promising but it threw an unhandled exception when I fed it an XSD I will use. Also, I don't think it does validation rules.

A:

I am                  And(CTRL, 0x1D, CTRL)

#if 0 // For now, nothing to do
                    If (Not(And(CDW1, 1))) { // Query flag clear?
                        // Disable GPEs for features granted native control.
                        If (And(CTRL, 0x01)) { // Hot plug control granted?


Growth and the new political economy

10 September 2012

The UK economy continues to falter in the hands of a Coalition government who look a long way from finding a strategy for growth.

The centre-left has the political momentum, but dealing with the entrenched legacy of 30 years of neoliberalism and changing economic orthodoxy is trickier than many expected. It requires a capacity to make tough choices and a better blend of realism and bold experimentation.

To that end, Policy Network continues it's work on the future of the political economy with a series of memos on growth strategies and the political dilemmas they present.

Memo to the ChancellorRichard Lambert
Britain's economic outlook continues to deteriorate. There is an urgent need for the Chancellor to come up with a bold and credible plan toQ:

What does the FreeBSD kernel message "vnode_pager_putpages: I/O error 5" mean?

Our FreeNAS file server's /var/log/messages and dmesg logs are filling up with:
Nov 28 14:50:00 chef kernel: vnode_pager_putpages: I/O error 5
Nov 28 14:50:00 chef kernel: vnode_pager_putpages: residual I/O 12288 at 1

My gut feeling is that the SATA drive on which swap resides is going bad. But SMART shows no errors, and I don't see any log messages about I/O errors for /dev/ada2... furthermore, the same physical drive swap is on (/dev/ada2) has a ZFS partition (/dev/ada2p2) which reports no I/O errors nor checksum errors. I'm tempted to do a zpool scrub but don't want to kill the disk if it is actually failing.
I googled for this error but the results were... not definitive.
What does the FreeBSD kernel message


to understand Microsoft Azure virtual network

How to describe Microsoft Azure storage

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8of our registrants for the January 4th workshop will be entered to win afull2 dayAzure Fundamentalscourse.

To Register for the free half-day workshop and be entered to win the full 2 day Azure Fundamentals course, clickhere.any other way, and which any sensible person should have seen at the time.

Despite sufficient proof of his plagiarism being there for anyone who chose to look, Hari responded to these initial claims by denying any wrongdoing. He tweeted:

'When interviewing a writer for a 6000-word profile, accurately quoting their writing is not "plagiarism" or "cut & paste journalism"'

That annoyed me – he had been caught, and in denying the obvious was only making it worse. But it also annoyed me that professional journalists on the left were so blind to this as to either dismiss or minimise the allegations and defend Hari. Owen Jones tweeted:

'In scheme of things, Johann Hari's "offences" are minor and the reaction is disproportionate. Twitter mob need to put their pitchforks down'

Either Owen Jones


long respected thought it didn't deserve to be looked at properly. Every time I looked at another of Hari's articles I found plagiarism, and I wrote about most of them on this site. As Brian's article should already have made plain would be the case, Hari had plagiarised extensively for years.

III. The Unbearable Shonkiness of Hari

It eventually turned out that Hari had also spent a lot of time smearing perceived rivals under an elaborately concocted identity on Wikipedia. This was seen by many as a greater ‘sin’ than the plagiarism – it certainly garnered more column inches. And almost completely ignored in the furore about his plagiarism and the surreal lengths he went to to protect his “David Rose” sockpuppet from being uncovered, it looks like Hari mightand how to 'clean up' quotes is flexible, to a degree. Hari counted on this in that weaselly apology. He used the flexibility to excuse his own (barely accounted for) plagiarism. A journalist who is more likely to clean up a quote that bit too much is all the more likely to buy Hari’s explanation. But it's a false argument, used by Hari to disguise his own dodgy journalistic practices. Journalists should always strive to make quotes as close to what was said as possible, and preferably identical. Because you don't want to be unfair, inaccurate or lie about what people have said.

With around a decade’s experience as a journalist, Hari should of course have known all of this by the time of his disgrace. In his 2011


times or so, you're not doing cool enough stuff.If your demo does crash every couple of dozen times or so... maybe you shouldn't be demoing it yet. Or maybe you shouldn't be pushing bugs into an "end of milestone" bug bash phase - but should be fixing them as you go.

I agree with Richard. Demos are expected to crash at some point. Don't let the chattering nitwits get in the way, keep pushing the limit and keep showing it publically. Most folks really don't care if it crashes or not.

I've seen blue screens on airport information boards, cash machines & registers, interactive booths at museaums & art galleries... hell even 40ft high advertising spaces! It's pretty common unfortunately, and I'd bet a lot more people have seen it§ 555.409, subd [1] [a] [Stat Ann 1957 Cum Supp § 19.535(9), subd (1) (a)]).
As to the contract itself, a similar problem is presented, although, unlike the negotiable instrument, the conditional sales contract is not referred to by name in the defining section. It seems clear, however, that it is an "instrument" within the definition thereof found in the act,[4] it providing, in further part, that the term instrument shall include any *582 "credit * * * instrument * * * marketed in the ordinary course of business or finance, of which the trustee, after the trust receipt transaction, appears by virtue of possession and the face of the instrument to be the owner." These requirements are here satisfied. The conditional sales contract is a credit instrument, it


to be protected against the entruster who has taken that risk by entrusting."
Appellant argues, finally, that "the plaintiff is not a bona fide purchaser of the property described in the writ of replevin issued in the above entitled cause, for the reason that:
"3. * * * He (Mr. Carter, an official of plaintiff bank) did not request the said Milbourn Trailer Sales, Inc., to produce a certificate of title, or certificate of origin, for said mobile home, contrary to the statutes of the State of Michigan, being * * * *585 (CLS 1956, § 257.233 [Stat Ann 1952 Rev § 9.1933]; CL 1948, § 440.20 [Stat Ann § 19.260])."
As supporting this argument defendants cite, among other cases, Bayer v. Jackson City Bank & Trust Co., 335 Mich 99,prevented Manchester City achieving the supremacy they wanted in European football just like the UN Arms Embargo prevented the UAE gaining supremacy in Libya. In both cases, Qatar was their key adversary in a proxy war. In both cases leaked emails, for which the UAE holds Qatar responsible, revealed the UAE’s complete disregard for the rules, and the fact that they paid people involved vast sums of money to corrupt the system. And what is more, they continue to do so. In June 2019, the New York Times revealed that a cache of powerful US-produced anti-tank missiles had been discovered in the arsenal of General Khalifa Hifter, the UAE’s man in Libya. The marking on the missiles’ shipping containers revealed they were sold to the UAE in 2008.


their attacks on neighbouring Qatar or their full-throated support for the UAE’s involvement in regional conflicts, notably Yemen. Loyalty and support provides a foundation for the exercise of power and it’s inconceivable that the powers in Abu Dhabi did not notice how City fans circled the wagons and acted as the frontline of defence to media criticism.

Simon Pearce, in particular, would have noted the existence of another group of Cityzens — the term coined by the club itself for its supporters — willing to defend their leaders come what may. Pearce might not be familiar with the dysphoric pathway to identity fusion but he knows an opportunity when he sees one and since 2018 we have seen a new phase in City’s PR operations, and one that hasthe 2022 World Cup. And, of course, the government that has been most keen on stripping Qatar of the World Cup is the same government that runs Manchester City.

All of which is to say that if Rabin is not part of an online propaganda campaign paid for by Abu Dhabi, then he should send Simon Pearce his CV and an invoice. If he is, then people — including policymakers and those in charge of football governance — need to pay attention.

Elite european football is now drenched in petrodollars, and English football is in danger of following suit. The proposed Qatari investment in Leeds United would almost certainly make them a powerful force as would any serious Gulf investment in Newcastle United — whether that be from figures in


of allograft cell viability and vascular ingrowth was seen in allograft explants. T2 mapping may provide an accurate noninvasive measure of early cartilage degeneration after meniscectomy, as well as cartilage protection after meniscal allograft transplantation. This study establishes a reliable animal model for meniscal allograft transplantation and provides evidence for the utility of T2 mapping at clinically relevant magnetic resonance imaging field strengths for evaluation of early cartilage degeneration.but even a cursory glance at his filmography shows a course correction that began in 1988. Even Lee noticed it; in the introduction to his Do the Right Thing companion book the following year, he acknowledged Coming to America as “a serious move by Eddie Murphy to do a film by and about Black people.” (More than that, it was a movie that didn’t make a big deal about its blackness; as Landis recalled, “I realized this is an opportunity to do something really important that nobody will notice… It was so successful; no one ever refers to that as an African-American movie. Ever. Yet it has three speaking parts for white people. Every other speaking role is an African-American.”)

So Murphy did, in fact, create opportunities in the


(a perception all but confirmed by the receipts read in the Buchwald trial). Writing in the short-lived New York magazine 7 Days, Louis Menand took the allegory further: “It’s the story of a man who lives in a fantasy world where every desire is satisfied and where everyone loves him. But he fears for his true self, the man he was before his wealth and success, and he dreams of returning to the mean streets of his beginnings and discovering his true soul’s companion. He doesn’t want the mean streets, though, he wants the royal palace; and when he finds his soulmate, that is where he expects to return. Wealth will then be a just reward — the reward for being true to himself.

“Zamunda, in short, is Hollywood,make, id. § 387e(i)(1), and those lists must be updated
biannually to reflect current offerings, id. § 387e(i)(3).

       The TCA likewise prohibits manufacturers from introducing any “new
tobacco product” without premarket authorization. Id. § 387j(a). A tobacco
product is considered “new” if it “was not commercially marketed in the United
States as of February 15, 2007.” 7            A manufacturer can obtain premarket
authorization through two primary channels: (1) by tendering a “premarket
tobacco application” (“PMTA”) demonstrating that the product “would be
appropriate for the protection of the public health,” id. § 387j(a)(2), (c)(2)(A); or
(2) by submitting a “report” showing that the product “is substantially equiv-
alent to a tobacco product commercially marketed” before February 2007, id.
§ 387j(a)(2)(A)(i). 8 The


                  No. 19-60921
and the United States Vaping Association, an ENDS industry trade associa-
tion, sued the FDA, contending that the TCA unconstitutionally delegated to
the Secretary the power to deem tobacco products subject to the Act’s man-
dates. The plaintiffs requested, inter alia, (1) a declaration that section 901
violates the nondelegation doctrine and (2) an injunction preventing the FDA
from enforcing the TCA against them.

      Shortly after filing suit—and in response to a forthcoming change in
federal enforcement strategy—the plaintiffs moved for a preliminary injunc-
tion enjoining the FDA “from exercising any authority over any ‘tobacco prod-
ucts’ deemed to be subject to the TCA . . . .” The FDA opposed thedelegation.

       Start with statutory purpose. The plaintiffs suggest that the TCA’s pur-
poses are “various and diverse,” so much so that they “are in actual tension
with one another.” To come to that conclusion, the plaintiffs essentially ignore
Section 3 of the TCA, which is aptly labeled “PURPOSE.” 24

       In that section, Congress stated that the TCA was meant “to ensure that
the [FDA] has the authority to address issues of particular concern to public
health officials, especially the use of tobacco by young people and dependence
on tobacco.” TCA, § 3(2), 123 Stat. at 1781. Another purpose was “to provide
new and flexible enforcement authority to ensure that there is effective over-
sight of the tobacco industry’s efforts to develop, introduce, and promote


protecting public health and (2) preventing young people
from accessing (and becoming addicted to) tobacco products.

       That purpose was informed by Congress’s extensive fact-finding. See id.
§ 2, 123 Stat. at 1776–81. Congress concluded that, for several reasons, tobacco
products posed a significant risk to children: (1) “[T]obacco products are inher-
ently dangerous and cause cancer, heart disease, and other serious adverse
health effects”; (2) “[n]icotine is an addictive drug”; (3) “[v]irtually all new users
of tobacco products are under the minimum legal age to purchase such prod-
ucts”; and (4) “[t]obacco advertising and marketing contribute significantly to
the use of nicotine-containing tobacco products by adolescents.” Id. § 2(1)–(5),
123 Stat. at 1777. And Congress meant for the FDA to attack those problems
comprehensively, 25 that is, in an “all-encompassing or sweeping”The TCA’s targeted statements of purpose and voluminous fact-
finding make that incontrovertible.

       Instead, the TCA’s deputizing of the Secretary mirrors SORNA’s delega-
tion to the Attorney General. In enacting SORNA, Congress sought “to combat
sex crimes and crimes against children” by creating “‘more uniform and effec-
tive’ . . . sex-offender registration systems.” Gundy, 139 S. Ct. at 2121 (plur-
ality) (quotation marks omitted). For sex offenders convicted after SORNA,

       27 See Pan. Ref., 293 U.S. at 417−418 (observing that Congress “la[id] down no policy
of limitation” in Section 9(c), and its general policy statement “contain[ed] nothing as to the
circumstances or conditions in which transportation of petroleum or petroleum products
should be prohibited”); Schechter, 295 U.S. at 541 (noting that that Section


handled, as well as remaining stable after incubation in water were chosen for further study.

TTO:PVA (poly\[vinyl alcohol\]) emulsions were prepared by probe sonicating (Bandelin Sonopuls HD2200, Bandelin Electronic, Berlin, Germany) TTO and 10% *w*/*v* PVA (35:65 *v*/*v* ratio) for 1 min. TTO:PVA-loaded hydrogels were prepared by substituting or adding sufficient emulsified TTO as part of the PVA component in the formulations to produce hydrogels with final TTO concentration of 5% or 7% *v*/*v*.

TTO-encapsulated hydrogel discs (8 mm diameter) were incubated in 20 mL PBS at room temperature. At time zero and at every hour up to 6 h, 6 mL of PBS was sampled, and replaced by 6 mL of fresh PBS. Further samples were taken after 7.5 and 24 h. Subsequently the amount of TTO and chitosan(C~H1.25(13)~Na-P~50(4)~TTO~35(4)~) and 30.667 mm (C~H2.5(22)~Na-P~50(7)~TTO~35(8)~PVA~10(5)~) were observed. Formulation C~H1.25(10)~Na-P~25(7)~TTO~35(4)~ was shown to have a ZOI against *P. aeruginosa*. The results in [Figure 4](#medicines-03-00008-f004){ref-type="fig"} indicated that changes in hydrogel composition can affect their respective antimicrobial activities, possibly due to alterations in physicochemical properties of the gels.

The activity of Ag^+^ hydrogels will be discussed based on the viscosity of chitosan and concentration of AgNO~3~ because it has electrostatic crosslinking properties that affect the stability of the resultant hydrogels as well as their antimicrobial activity. In Ag^+^ hydrogels, the order of sensitivity also follows the MLC order of Ag^+^ reported in Low *et al.*, 2011 \[[@B43-medicines-03-00008]\], *i.e.*, *C. albicans* \> *P. aeruginosa* ≥ *S. aureus* ([Figure 5](#medicines-03-00008-f005){ref-type="fig"}), when the concentration of Ag^+^ is \>0.2117% *w*/*v*. However, when the concentration is ≤0.2117%