grad4yrs],method = 'rf', trControl = fitControl, ntree=1000, tuneLength = 10)

#print info on accuracy & kappa for "BOTH" training model
# print(RF_model_both)
# Random Forest
#
# 2346 samples
# 40 predictor
# 2 classes: '0', '1'
#
# No pre-processing
# Resampling: Cross-Validated (10 fold, repeated 5 times)
# Summary of sample sizes: 2112, 2111, 2111, 2112, 2111, 2112, ...
# Resampling results across tuning parameters:
#
#   mtry  Accuracy   Kappa
# 8    0.9055406  0.8110631
# 11    0.9053719  0.8107246
# 12    0.9057981  0.8115770
# 13    0.9054584  0.8108965
# 14    0.9048602  0.8097018
# 20    0.9034992  0.8069796
# 26    0.9027307  0.8054427
# 30  location ${{\pmb \theta}}$ and concentration $\kappa$ (notation: ${\cal M}_{p}({{\pmb \theta}},\kappa)$)[, that is, to $g(t)=\exp(\kappa t)$,]{} gives $c_{p,g}=c^{\cal M}_{p, \kappa}=\kappa^{\frac{p-2}{2}}/((2\pi)^{\frac{p}{2}} I_{\frac{p-2}{2}}(\kappa))$, where $I_\nu$ is the order-$\nu$ modified Bessel function of the first kind.

The proposed tests {#sec:thetests}
------------------

In view of the above considerations, it is natural to test the null of rotational symmetry about ${{\pmb \theta}}$ by testing that ${\ensuremath{\mathbf{u}}}_{{{\pmb \theta}}}({\mathbf{X}})$ is uniformly distributed over $\mathcal{S}^{p-2}$. Since there are extremely diverse alternatives to uniformity on $\mathcal{S}^{p-2}$, one may first want to consider *location* alternatives and *scatter* alternatives, the ones associated with violations of the expectation and the covariance conditions in , respectively. The tests we propose in this paper are designed to detect such alternatives.\
Let ${\mathbf{X}}_1,\ldots,{\mathbf{X}}_n$ be a random sample from a distribution on $\mathcal{S}^{p-1}$ and consider the problem of testing the null $\mathcal{H}_{0,{{\pmb \theta}}}:$ “${\mathbf{X}}_1$ is rotationally symmetric about ${{\pmb \theta}}$”.


\theta}}}({\mathbf{X}})$. Vice versa, it directly follows from the tangent-normal decomposition in  that any rotational distribution on $\mathcal{S}^{p-1}$ can be obtained as the distribution of $$\begin{aligned}
\label{ff}
V {{\pmb \theta}}+
\sqrt{1-V^2}
\
{{\pmb \Gamma}}_{{{\pmb \theta}}}
{\ensuremath{\mathbf{U}}},\end{aligned}$$ where ${\ensuremath{\mathbf{U}}}$ is a random vector that is uniformly distributed over $\mathcal{S}^{p-2}$ and where the random variable $V$ with values in $[-1,1]$ is independent of ${\ensuremath{\mathbf{U}}}$. In this section, we introduce natural alternatives to rotational symmetry by relaxing some of the distributional constraints on ${\ensuremath{\mathbf{U}}}$ in . Rather than assuming that ${\ensuremath{\mathbf{U}}}$ is uniformly distributed over $\mathcal{S}^{p-2}$, we construct two families of non-rotationally symmetric distributions for which ${\ensuremath{\mathbf{U}}}$ follows an *angular central Gaussian distribution* ([@tyler1987]) and a vMF distribution.\
For the first family, recall that the random $(p-1)$-vector ${\ensuremath{\mathbf{U}}}$ has an angular central Gaussian distribution on $\mathcal{S}^{p-2}$ with shape parameter ${{\pmb \Lambda}}$ (notation: ${\ensuremath{\mathbf{U}}}\sim \mathcal{A}_{p-1}({{\pmb \Lambda}})$) if it admits the density ${\ensuremath{\mathbf{u}}}\mapsto c^{\calthe Giné’s ($F_n$) test; see pages 99 and 209 of [@MJ00], respectively. This generates a Kuiper test $\phi_{{\pmb \theta}}^{\rm KU}$ of rotational symmetry on $\mathcal{S}^2$ and a Giné test $\phi_{{\pmb \theta}}^{\rm GI}$ of rotational symmetry on $\mathcal{S}^{p-1}$ with $p>3$, both about a specified ${{\pmb \theta}}$. Since they are based on omnibus tests of uniformity over $\mathcal{S}^{p-2}$, both $\phi_{{\pmb \theta}}^{\rm KU}$ and $\phi_{{\pmb \theta}}^{\rm GI}$ are expected to show some power against both tangent vMF and tangent elliptical alternatives. Still for the specified-${{\pmb \theta}}$ problem, we will also consider the semiparametric test from [@LVD16], denoted as $\phi_{{\pmb \theta}}^{\rm LV}$. Now, for the unspecified-${{\pmb \theta}}$ problem, we will restrict to the proposed semiparametric tests $\phi_{\dagger}^{\rm sc}$, $\phi_{\rm vMF}^{\rm loc}$, and $\phi_{\rm vMF}^{\rm hyb}$, from Sections \[sec:scattertestunsp\], \[sec:locationtestunsp\], and \[sec:hybrid\], respectively. To the best of our knowledge, indeed, these unspecified-${{\pmb \theta}}$ tests have


no competitors in the literature. In particular, it is unclear how to turn the omnibus specified-${{\pmb \theta}}$ tests $\phi_{{\pmb \theta}}^{\rm KU}$ and $\phi_{{\pmb \theta}}^{\rm GI}$ into unspecified-${{\pmb \theta}}$ ones.

The unspecified-theta problem on S2 {#sec:simuunspec}
-----------------------------------

The first simulation exercise focuses on the unspecified-${{\pmb \theta}}$ problem and intends to show, in particular, that using specified-${{\pmb \theta}}$ tests with a misspecified value of ${{\pmb \theta}}$ leads to severe violations of the nominal level constraint. For two sample sizes ($n=100,200$) and two types of alternatives to rotational symmetry ($r=1,2$), we generated $N = 5,\!000$ mutually independent random samples of the form $${{\mathbf{X}}}_{i;\ell}^{(r)}, \quad
i=1,\ldots, n,  \quad
\ell=0, \ldots, 5,  \quad
r=1, 2,$$ with values in $\mathcal{S}^2$. The ${{\mathbf{X}}}_{i;\ell}^{(1)}$’s follow a $\mathcal{TE}_3({{\pmb \theta}}_0,g_1,{{{\pmb \Lambda}}}_{\ell})$ with location ${{\pmb \theta}}_0:=(1/\sqrt{2}, -1/\sqrt{2}, 0)^T$, angular function $t\mapsto g_1(t):=\exp(2t)$, and shape ${{{\pmb \Lambda}}}_{\ell}:=2{\rm diag}(1+\ell/2,1)/(2+\ell/2)$. The ${{\mathbf{X}}}_{i;\ell}^{(2)}$’s follow aby the sun’s differential rotation (solar plasma rotates slower near the poles than at the equator) to produce a spiral wrapping of the magnetic field, with an amplification of the field strength that depends on the *latitude*. The magnetic buoyancy of locally intense concentrations of the field pushes inner magnetic flux tubes up to the solar surface, forming BMR and producing sunspots as the result of the intersection of BMR with the solar surface. The (magnetic) field intensity required for producing BMR is reached at progressively lower latitudes as the twisting of the initial field advances, a phenomenon known as the *Spörer’s law*. After about 11 years, the magnetic field behaves as a dipolar field of reversed polarity. This period constitutes a *solar cycle*. The process repeats itself,


of the cosines $v_{{{\pmb \theta}}_0}({\mathbf{X}}_i)= {\mathbf{X}}_i^{T} {{\pmb \theta}}_0$, $i=1,\ldots,n$; see –. The left panel in Figure \[fig:2\] provides a plot of the kernel density estimator (kde) $\hat{\tilde{g}}_p$ based on Gaussian kernel and the direct plug-in bandwidth selector [@Sheather1991]. Note that, since the sample stays away from the endpoints of $[-1,1]$, it is not required considering a kde that would specifically address issues associated with boundary effects. Then, from – and since $p=3$, the final estimator for the density is then $\hat{f}({\ensuremath{\mathbf{x}}})= \omega_{p-1}^{-1}\hat{\tilde{g}}_p({\ensuremath{\mathbf{x}}}^{T} {{\pmb \theta}}_0)$. Given the large sample size and the fact that only a univariate density was estimated nonparametrically, one may be confident that $\hat{f}$ is a good estimate of $f$. The kde $\hat{\tilde{g}}_p$ can be applied for further quantitative description of the data (see [@Chacon2018] for a survey of applications). In particular, itdistributions on the unit sphere and related efficient inferential procedures. , 159:67–81.

Lo, A. Y. and Cabrera, J. (1987). Bayes procedures for rotationally symmetric models on the sphere. , 15(3):1257–1268.

Mardia, K. V. and Jupp, P. E. (2000). . Wiley Series in Probability and Statistics. John Wiley & Sons, Chichester, second edition.

Meintanis, S. and Verdebout, T. (2019). Le [C]{}am maximin tests for symmetry of circular data based on the characteristic function. , to appear.

Paindaveine, D. and Verdebout, T. (2015). Optimal rank-based tests for the location parameter of a rotationally symmetric distribution on the hypersphere. In , , , and , editors, [*Mathematical Statistics and Limit Theorems: Festschrift in Honor of Paul Deheuvels*]{}, pages 249–270. Springer.

Paindaveine, D. and Verdebout, T. (2016). On high-dimensional sign tests. , 22(3):1745–1769.

Paindaveine, D. and Verdebout, T. (2017). Inference


\Lambda}}_n\big)
    -
    \frac{p-1}{2} \sum_{i=1}^n \log\big({\bf U}_{i,{{\pmb \theta}}_n}^{T}{{\pmb \Lambda}}_n^{-1} {\bf U}_{i,{{\pmb \theta}}_n}\big)
    =:L_{n,1}+L_{n,2}
    ,
    \end{aligned}$$ say. Since $\log({\rm det}({\bf I}_{p-1}+ {\bf A}))={\rm tr}[{\bf A}]- \frac{1}{2}{\rm tr}[{\bf A}^2]+o(\| {\bf A}\|^2)$ as $\| {\bf A}\| \to 0$, we have that $$\begin{aligned}
    \label{constterm}
    L_{n,1}
    =
    -\frac{n}{2} \log\big({\rm det}({\bf I}_{p-1}+n^{-1/2}{\mathbf{L}}_n)\big)
    =
    \frac{1}{4} {\rm tr}[{\mathbf{L}}_n^2]+o(1)
    \end{aligned}$$ as ${n\rightarrow\infty}$ (recall that ${\rm tr}[{\mathbf{L}}_n]=0$). Now, write $$\begin{aligned}
    L_{n,2}
    &=
    -
    \frac{p-1}{2}
    \sum_{i=1}^n \log\big(1+{\bf U}_{i,{{\pmb \theta}}_n}^{T}({{\pmb \Lambda}}_n^{-1}- {\bf I}_{p-1}) {\bf U}_{i,{{\pmb \theta}}_n}\big)
    \\
 details. \[power4d\]](images/Power4dnew.pdf){width=".9\textwidth"}

Mixtures {#sec:simusmix}
--------

For the last simulation exercise, we consider two types of mixture distributions on ${\cal S}^2$: mixtures of vMF distributions ($r=1$) and mixtures of tangent vMF and tangent elliptical distributions ($r=2$). For sample sizes $n=100$ and $n=200$ and for both types of mixtures, we generated $N=5,\!000$ mutually independent random samples of the form ${{\mathbf{X}}}_{i;\ell}^{(r)}$, $i=1,\ldots, n$, $\ell=0, \ldots, 5$, $r=1,2$, with values on $\mathcal{S}^2$. The ${{\mathbf{X}}}_{i;\ell}^{(1)}$’s are distributed as the mixture $\frac{1}{2} {\ensuremath{\mathbf{Y}}}+ \frac{1}{2} {\mathbf{Z}}_{\ell}$, where ${\ensuremath{\mathbf{Y}}}$ and ${\mathbf{Z}}_{\ell}$ are independent vMF random vectors with respective locations ${{\pmb \theta}}=(1, 0, 0)^T$ and ${{\pmb \theta}}_\ell=(\cos(\ell/40), \sin(\ell/40), 0)^T$ and common concentration $\kappa=5$. The ${{\mathbf{X}}}_{i;\ell}^{(2)}$’s are distributed as the mixture $\frac{1}{2} {\mathbf{Z}}_{1, \ell}+ \frac{1}{2} {\mathbf{Z}}_{2, \ell},$ where ${\mathbf{Z}}_{1, \ell}\sim \mathcal{TM}_3({{\pmb \theta}}, \exp(5u), {\pmb \mu}, \kappa_\ell)$ and ${\mathbf{Z}}_{2, \ell}\sim \mathcal{TE}_3({{\pmb \theta}}, \exp(5u), {{\pmb \Lambda}}_\ell)$ are independent, with ${{\pmb \theta}}=(1, 0, 0)^T$,


Angeles whose father was a famous actor.

5. What is your character’s name? Not just the nickname he’s using now, but his full heritage. First, last, middle, and what his teacher called him in grade school. Do your research - there’s plenty of web help on first and last names - names by region or ethnicity, historical names.

6. Describing your character. This applies to both physical traits and emotional ones, visible and invisible.

8. How your character feels at the beginning of your story - or of his appearance in your story. The characters feelings will of course change, as they must for the drama of your story to occur - but how does he feel when you first begin?

Some characters - your p.i., your romantic swashbuckling hero, your biographicalsubject - will remain in a more fixed emotional state than others. But regardless of how much your character does or wants to change - or not - you need a sense of how that person is feeling at the beginning of his role in your story.A caveat — just because you need to know this information about your character, your reader may not.Genie Davis is a published novelist and produced screen and television writer. Her noir flavored romantic suspense The Model Man (Kensington) received the Road to Romance Reviewer’s Choice Award. A second humor infused romantic suspense, Five O’Clock Shadow (Kensington) has been released both in the U.S. and in multi-country foreign markets. Her erotic romance novella Rodeo Man was released under the name Nikki Alton in


3:

Presnap: Showing 2 high deep, the linebackers are now aligned over Ebron and Dwayne as opposed to aligning over the guards in the first two plays. With all 3 corners close to the LoS, we have ourselves a two high man look. The key to this play revolves around manipulating the strong side safety and making a decision based on his assignment. We see a high-low read in the middle with Boldin running an underneath drag to draw the Linebackers up to possibly hit Ebron over the top with a skinny post. Dwayne Washington is running a flat route to clear out the linebacker assigned to him. And Marvin will work vertically on his man to draw the safety away from the middle of the field.

Post-Snap: Stafford’s eyesToronto might finally be taking steps to address the shrinking number of music venues. City councillors Josh Colle and John Filion are bringing forward a motion on November 9 that calls for the chief planner and general manager of economic development to come up with a strategy to preserve existing music venues and facilitate the opening of new ones.

The loss of spaces is “not just an idle threat: we’ve lost two venues since I started working on this motion,” Colle tells NOW. “I get that some of this is just the evolution of a city. These kinds of uses move from one area to another due to cost or maybe cool factor. If you look at all the condos that are approved and that are coming, there’s not


---
abstract: |
    On base of Hamiltonian formalism, we show that Hopf bifurcation arrives, in the course of the system evolution, at creation of revolving region of the phase plane being bounded by limit cycle. A revolving phase plane with a set of limit cycles is presented in analogy with revolving vessel containing superfluid He$^4$. Within such a representation, fast varying angle is shown to be reduced to phase of complex order parameter whose module squared plays a role of action. Respectively, vector potential of conjugate field is reduced to relative velocity of movement of the limit cycle interior with respect to its exterior.

    [**Key words:**]{} Fast and slow variables; Limit cycle; Gauge field; Order parameter.

    PACS numbers: 05.45.-a, 05.65.+b
author:
-parameter, very in self-consistent manner [@OC]. Roughly speaking, a generalization of thermodynamic picture due to passage to synergetic one is stipulated by extension of set of state parameters from single parameter to three ones, being above pointed out. It might hope that such a generalization allows one to describe not only the simplest Landau-like bifurcation, but much more complicated Hopf one, when a limit cycle is created to be continuous manifold instead of discrete one [@H].

Our considerations of this problem have shown [@UFJ] that using the whole set of universal deformations within standard synergetic scheme does not arrive at stable limit cycle, whereas running out off the standard scheme of self-organization has allowed us to obtain the limit cycle shown in Fig.1 [@1].

![The limit cycle related to non-standard


relation $\vec\omega=(1/2){\rm rot}~{\bf w}$ between the angular and linear components of the revolving velocity.

Well-known example of such type behaviour represents the case of revolving superfluid He$^2$ [@9]. Along this line, an effective potential density of the revolving phase plane, including a set of limit cycles, has the following form [@GLA] $$E=\Delta E(\eta)+\frac{1}{2}\Big|\left(-{\rm i}s\nabla-{\bf
w}\right)\eta\Big|^2+\frac{I}{2}\omega^2.
 \label{15}$$ Within the phenomenological scheme, the density of the potential variation due to limit cycle creation is given by the Landau expansion $$\Delta E(\eta)=A\eta^2+\frac{B}{2}\eta^4
 \label{16}$$ whose form is fixed by parameters $A$, $B$. The second term of Eq.(\[15\]) determines heterogeneity energy with the gradient, being prolonged by the vector potential ${\bf w}$ of the gauge field. The last term is the kinetic energy of the revolving phase plane.

Under an external influence with frequency $\vec\omega_0$, the(milo), and wheat. Carbon disulfide is also useful as a nematocide for other preplanted (fallow) soil. The amount of carbon disulfide, recommended for this use, would be phytotoxic if applied to growing plants.
Numerous compositions possessing nematocidal properties have been developed, including active ingredients such as the polyamines of U.S. Pat. No. 2,979,434 to Santmyer, the heterocyclic compounds of U.S. Pat. No. 2,086,907 to Hessel, and various halogenated compounds. Among the useful halogen-containing nematocides are 1,2-dibromoethane, methyl bromide, 3-bromopropyne, 1,2-dichloropropane, ethylene dichloride and others, all of which are quite phytotoxic, therefore restricting their utility to mostly preplanting treatments.
One compound which enjoyed considerable commercial success is 1,2-dibromo-3-chloropropane (DBCP), which can be used to control nematodes in soils with growing perennial plants. However, use of this material has been limited due


Q:

symfony2 where to store reusable bundle

Question is where to store reusable bundle?
Example.
There is few application (AppA, AppB, AppC) that uses My/ReportsBundle.
All those apps have composer.json
"require": "my/reports-bundle:1.0.x-dev"

Now. When any developer needs to make changes to My/ReportsBundle, he goes vendor/my/reports-bundle/My/ReportsBundle directory.
Make changes.
Commit them to git.
then others can just use composer update to get updates.
But there is constant mentions that we should avoid to alter vendor contents.
So, my question what is best practice for placing and developing reusable symfony2 bundle?

A:

If you have multiple apps using single package, you have to treat it like an open source package. Develop is standalone and tagged. Because fixing package in your AppA, could break it in AppB without even it's use knowing.
So I'd maintain standalone package, like you'd like to contribute some package on Githubu.

in this State, was found wandering in a helpless, mentally deranged condition in the Village of Mound, Hennepin County. His mental condition was such that the sheriff of the county removed him to the Hennepin County Jail, and while so confined he became so violent that the jailer called the matter to the attention of the court commissioner of the county. Pursuant to statutory authority (Minn.Stat.1941, § 525.751), the court commissioner ordered the removal of the plaintiff to the Minneapolis General Hospital and his temporary confinement in the mental ward thereof for observation and examination and the necessary restraint pending proceedings for his commitment as an insane person. It was during such restraint, and on July 22, 1945, that he alleges he was assaulted by the orderly, which


welfare of the community at large depends upon the health and well-being of the poor and unfortunate, who by reason of their circumstances are more apt to be subject to disease and misfortune than persons more fortunately situated.
Plaintiff stresses the fact that, after he had been admitted to the hospital, his wife came to the City and agreed to pay the sum required by the hospital authorities for his hospital care. While the sum agreed upon was never demanded, or paid by the plaintiff or anyone in his behalf, it would seem that this circumstance in determining the liability of the City becomes wholly immaterial. Certainly, the fact that plaintiff had agreed to pay a daily charge for his care in a hospital of this character does notSupreme Court in cases which it had under consideration where it held that the governmental agency was performing a governmental function notwithstanding that some consideration had been paid by those who were enjoying the facilities afforded by that particular activity. In Mokovich v. School District, supra, it appears that a boy was injured while playing football and lost the sight of one eye by reason of lime that was used as a gridiron line marker. The court held that the School District was not liable in that the football game was carried on in performance of the general educational activities of the District and that the incidental charge made for attendance by the public at the game did not transform a governmental function into a private one. Furthermore,


starter Raul Valdes that set the rhythm and quelled the BayStars’ offense until a lapse by the lefty in the third.

Ricardo Nanita had a leadoff double to left leading off the second and Chunichi was on the scoreboard the very next at-bat, when Shuhei Takahashi doubled down the right-field line to make it 1-0.

Yokohama got a chance when Jose Lopez drew a one-out walk in the second, but the first baseman was thrown out by a mile when he tried to reach third from first on Aarom Baldiris’ bloop single to left, and the next batter was retired to end the inning.

The game took a twist in the home half of the third with a leadoff blast by second-year man Minei — his first career homer. Leadoff manwin.

Buffaloes 7, Fighters 3

At Sapporo Dome, Orix rallied in a four-run seventh inning, featuring pinch hitter Naotaka Takehara’s three-run shot as the Buffaloes routed Hokkaido Nippon Ham for their sixth win in seven games.

Marines 7, Eagles 3

At Sendai’s Kobo Stadium, Alfredo Despaigne delivered a go-ahead three-run drive off Takahiro Norimoto (1-3) in the third inning as Chiba Lotte battled past Tohoku Rakuten to snap a four-game skid.


Q:

Deny Direct Access to Lists in SharePoint-Hosted Add-in

Not finding any real answer to this question, so not sure if I am articulating my question correctly...
SCENARIO:
I am creating an college registration form for students using a SharePoint-hosted Add-in. Requirements make it thus and MUST be all self contained rather than split up (cross-domain). Therefore, lists and libraries are created by the add-in when deployed. Students are able to register and add documents just fine.
The problem I am seeing is that if a student happens to know the direct URL to the list or library, instead of using the GUI design, he/she would then be able to view/edit all the other student records and personal information.
Aside from naming the lists crazy names, is there anything I can do? Worried thatsome one might read through a JavaScript file, and figure out locations. I want to force the user to ONLY use the GUI (ASPX page) and not see the SharePoint side of things.
CAVEAT:
There might be certain people who will need to access these lists directly to "Open with Explorer".

A:

The best way I have found is though security bits and to remove the allitems view from the list.


Alaskans. They hunt whales, seals, walrus, caribou and other game for food so they watch the weather and the changes in seasons closely.

I moved in with the Kaleak family who helped me get used to the cold. They lent me a fur parka and introduced me to native foods, including maktak, which is whale blubber and skin.

They also told me about the ice cellars melting. Many families have ice cellars, natural freezers down below the ground. As the climate in the North Slope warms, it is becoming more difficult to store food.

ON WHALE HUNT

In spring, people in Barrow start to get excited. It's whaling season.

The subsistence hunters get ready to travel out on the sea ice. Living with the Kaleaks, I learned that a huge amount of workice-hills with a pickaxe. When there is old ice in the ice pack the salt has drained out of it and it's possible to melt it for drinking and cooking.

The crew told me about the spiritual and ethical side of the hunt. Whales are hunted for food for the community, not for pleasure. You can't kill anything that will not be eaten; there is no waste in this harsh environment.

The Inupiat believe that the whales give themselves to deserving crews and the spirit of the whale will be reborn.


not understand, I was told that economists should
learn that language. And when I said in my post
on Mirowski that he knew more about the history of economics and
neoliberalism than I did, Lars Syll says
I should educate myself. Note that in none of these cases am I saying
there should be no engagement from economists: all three examples
come from cases where I did attempt to engage.

In economics we do not just learn about opportunitycost,
we also know about comparativeadvantage
and the divisionoflabour.
It makes sense to set up systems (in production, trade, research or
other things) where people do what they are good at, rather than just
do a bit of everything. In academia people specialise for good
reasons. To understand the macroeconomy better it really is sensible
that I spend most of my time reading macroeconomicyou can blame for ignoring economics
expertise. Voters themselves, the politicians that call such advice
Project Fear, the tabloid media that keeps expertise from the eyes of
their readers (or trashes it), the broadcast media for an obsession
with balance, underlying economic conditions that lead people to
think it cannot get any worse (a phrase I have heard a number of
times since the result). It is a long list, and in order of
importance the failures of economists themselves comes a long way
down it.

And before I get the inevitable comments about the failure to foresee
the financial crisis and the sins of neoliberal orthodoxy, please
note that the medium term costs of Brexit come largely from models of
trade, productivity and international investment which are very
empirical and hardly ideological. But if a respected Financial Times
columnist calls
economists’ assessment


of what that literature implies “the
profession’s intellectual arrogance” what can you do. Let’s get
real: what we said was ignored, and the reasons for that have very
little to do with economists themselves.sea, and the sky But every single night, before I go to bed I get down on my knees and thank God I'm a Bianca Andreescu fan Bianca Andreescu fan, Bianca Andreescu fan She slams herself a winner And she wins herself a slam She got one hell of a job to perform for the WTA Got the responsibility of a nation's sporting pride But every night and day, I salute the flag and say "Thank you, Jesus," 'cause I'm I'm a Bianca Andreescu fan Bianca Andreescu fan, Bianca Andreescu fan She slams herself a winner And she wins herself a slam You know they got me watchin' this, watchin' that And a little bit of something else Loud obnoxious screaming, and even louder crowds But not an


just makes up excuses when he is losing or can't perform well, eg: Lights are bothering my eyes, Was up late playing Fortnite, Don't feel like trying, Umpire is against me, Line Judge is making a poor call, Audience members are bothering me, opponent is taking too long between serves ... I feel like that's why he doesn't have a coach. He doesn't want hear someone critique him or point out his flaws because ignorance is bliss ... **smh**with two people who were in a van
      attempting to purchase cocaine. The nature of the disagreement is not
      entirely clear, but there is evidence that Mr. Lee thought he was owed
      forty dollars. Mr. Lee threatened to shoot the driver if he drove away.
      When the driver attempted to leave, Mr. Lee carried through with his
      threat. He shot the driver, who sustained permanent, disabling
      injuries. Mr. Lee was fifteen years old at the time of these events.
             The State filed an information charging Mr.


those movie producers that just found their next big
star :D

------
resoluteteeth
> For those of you that want to try out the AI noise removal capabilities but
> aren’t ready to upgrade to an RTX GPU yet, we have also patched RTX Voice
> with support for NVIDIA GeForce GTX GPUs. Though, of course, your mileage
> may vary on older cards.

That's a strange way to say "yeah we admit that we were just blocking older
GPUs in the installer and you guys noticed so decided to stop."

~~~
motoboi
Well it kinds looks like your car manufacturer stating in the manual that your
car cannot tow.

You know it just a matter of installing one, but they basically don't want to
spend time supporting something they have no interest in.

~~~
bluGill
In the case of cars often a car can tow,ratio was 18/5 and 19/16 respectively (p = NS), the glycosylated hemoglobin on admission was 12.6 ± 2.5 and 14.3 ± 2.7% respectively (p = 0.03), minimal blood pH was 7.15 ± 0.14 and 7.19 ± 0.09 respectively (p = NS), bicarbonate was required in seven and no patient respectively (p = 0.01), hypokalemia < 3.5 mEq/L occurred in 78.2 and 48.5% of patients (p = 0.03), the lapse until resolution was 28.7 ± 28.0 and 28.8 ± 20.6 hours (p = NS). Only one patient, treated following ADA 2009 guidelines, died. Introduction of the ADA-2009 protocol for the treatment of KAD resulted in decrease in the use of intravenous bicarbonate and a reduction in the incidence of hypokalemia. There was no impact neither in the lapse until


helped turn the tide of the war against the opposition. While Russia is not an imperialist power like the United States, its foreign policy is motivated by nationalist considerations, not international solidarity.

U.S. and Turkish military intervention in Syria: a blatant violation of international law

Flying in the face of an earlier U.S. statement on January 22 that “urged Turkey to exercise restraint in its military actions and rhetoric; ensure that its operations are limited in scope and duration,” Turkish president Recep Tayyip Erdoğan announced on January 26 that the military operation would extend east all the way to the Iraqi border, including Manbij where some U.S. troops are stationed. While the chances of a military confrontation between the United States and Turkey, both NATO members, are slim, the facton decentralized ledgers, they do not have trusted central authorities to validate the transactions.

This is why some argue that cryptocurrencies can potentially be susceptible to double-spending. Although cryptocurrencies instead rely on a vast network of decentralized validators working in unison, this is not always a fail-safe measure for protecting against double-spending.

More specifically, so-called ”51% attacks” where a single miner controls more than half of all the computational power allow for this sort of double-spending. For example, Toshi Times has previously covered how ZenCash fell victim to such a double-spend attack earlier this year.

The Bank of Canada study states that researchers modeled a system in order to explore where a digital ledger such as a blockchain could readily be cheated into double-spending, finally determining that the occurrence of wide-spread


-3*s = 10*d - 8*d, 2*s = -d - 1 for d.
3
Solve -3*z + 4*z = -5*s + 3, -2*s - 5*z - 8 = 0 for s.
1
Solve -i + 6 = -h - 0, h = -5*i + 12 for h.
-3
Solve 7*z - 3*g + 34 = 2*z, -5*g = 3*z for z.
-5
Solve -h = 3*n - 7*n - 5, 3*h + 3*n = 15 for h.
5
Solve 3*y + 3*r - 10 = 2*y, -4*r = -4*y + 8 for y.
4
Solve 6*j + 4*y - 10 = j, 0 = -5*j - y + 10 for j.
2
Solve -2*r = -f - 2, r + 11 = -2*r + 5*f for r.
3
Solve -22*l - 4*y + 16 = -23*l, 7 = -2*l + 3*y for l.
4
Solve -4*x =-5*k, -5*q - 13 = 5*k - 43 for k.
3
Solve -3*i - 3*w = w + 26, -2*w = 3*i + 16 for i.
-2
Solve -4*d - 2*a = -5*d - 5, 15 = -3*d + a for d.
-5
Solve -3*f - 3*d = 30 - 21, 21 = -4*f + 5*d for f.
-4
Solve -3*a + n = 1, -2*n + 4*n + 14 = -2*a for a.
-2
Solve -3*r - 5*g = -39 + 13, 0 = -4*r + 2*g for r.
2
Solve 2 + 0 = s - u, 0 = -3*s + 4*u + 8 for s.
0
Solve -3*w - 4 = 3*f + 8, 0 = 3*w - 4*f - 23 for w.
1
Solve 2 = -q, -11*q = -3*k - 10*q - 1 for k.
-1
Solve 2*m - 2 =


voted Australia’s best State for craft beer

- Australia voted the best beer producing nation in the World

- Pale Ale is the most consumed craft beer style in Australia

- Australian craft beer drinkers are frustrated by the beer selection at sporting and music events

- Australian craft beer drinkers believe the Government should do more to support the craft beer industry

The following is an outline of findings from the research. More detail is provided through the links provided.

Feral Brewing is Australia’s best craft brewery, with newcomer Pirate Life second. View the full results here, or see the results by state, or by capital city.

Pale Ale is Australia’s most consumed craft beer style, with India Pale Ales (IPAs) also widely enjoyed. View the full results here.

Victoria leads the way, taking theQ:

How to smooth a signal?

The easiest way to smooth a signal is by moving window average.
A more advanced way is to use a Savitzky-Golay filter.
From wikipedia:

The main advantage of this approach is that it tends to preserve
  features of the distribution such as relative maxima, minima and
  width, which are usually 'flattened' by other adjacent averaging
  techniques (like moving averages, for example).

There is also a whole range of window functions.
As I understand this: any finite filter wil cause spectral leakage,
but the moving window average is the worst. E.g. a Gaussian window is better in this respect.
Is flattening and spectral leakage the same?
When should one use Savitzky-Golay and when should one use Gauss, Hann, Hamming etc?
Thanks in advance for any answers!

A:

When using


or as a tangible object, one thing is certain: The model was a TV prop built as cheaply as possible almost half a century ago. It was never intended to be hung, and a series of X-rays taken in 1999 revealed stress fractures in the wood. The model has been displayed on a stand, as originally designed, since then.

Though it’s been restored three times already during its stay at the Smithsonian, it’s in need of a major overhaul to return it to something like its original status on the Starfleet duty roster, and that’s finally about to happen. After 13 years in the gift shop, NASM has removed the model from public view for restoration at the Museum’s Steven F. Udvar-Hazy center near Dulles International Airport in Virginia.feel like Adrenaline is also a little secret for those who are regulars because I don't think many people know it and there's also not too much noise on it.

NOSA: I think people know, but Four Points is just too stressful of an establishment

FOLLY: I liked the decor at Adrenaline, particularly the dark wood. I wasn't a fan of the low chairs are and the tiny tables, however.

NOSA: In its defense, it's a proper sports bar in every sense.

FOLLY: I was trying to be a rebel and I ordered a concoction cocktail listed on their menu. It's called the Seven Step and it had in it: gin, vodka, tequila, rum, Cointreau, creme de cassis and white wine.

You read that right, 7 types of alcohol and no mixer. I


on internet forums from time to time that shows a high school math test with a comment from a teacher that says “I don’t know how, but you used the wrong formula and got the correct answer.” I feel that a similar comment could be made about the decision to switch to five at the back with thirty minutes left and the ensuing win. To illustrate my point I would like to quote from Sir Alex Ferguson’s book Leading:

“...Frequently...The opposition played right into our hands by trying to defend their lead. They would substitute on a defensive player for an attacker and it would change the entire balance of the game. Suddenly we could surge around their box without worrying as much about their ability to counter-attack. Ourits late-November release date.

“There was a misprint in an endorsement quote from radio announcer Jackie O,” a spokesperson said. “This was missed in proofing, but subsequently corrected prior to the book’s publication.”

Jacenko has previously written three fiction books, and is married to the high-profile former stockbroker Oliver Curtis, who was convicted of insider trading in 2016.


pre-emptive force is.

Conclusion: the U.S. does not have a right to use force against Pakistan, either under the UN Charter or international customary law.

Armed Conflict with al-Qa’ida?

Al-Qa’ida certainly uses force. But it is not a state (nor a ‘liberation movement’), and has a global geography of adherents that are not easily identifiable. Under current international law and current legal frameworks, a state cannot therefore engage in an armed conflict with al-Qa’ida. Failure to satisfy this condition explains why the CIA is in control of drone strikes in Pakistan, since it removes American military personnel from direct legal responsibility. Outside of an armed conflict, peacetime criminal law should prevail. Human rights remain constant at all times.

Authorization for the Use of Military Force (AUMF)

U.S. domestic law has no bearings on
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Finally, we study the nonlinear ODE with a source. We prove that the


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Our main result is the following theorem.

### Theorem 2.5 {#FPar7}

(Main Theorem) Let assumptions ([1.2](#Equ2){ref-type=""}), ([1.3](#Equ3){ref-type=""}) and ([1.4](#Equ4){ref-type=""}) hold and let $\documentclass[12pt]{minimal}
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Singular Component {#Sec7}
==================

Due to ([3.9](#Equ28){ref-type=""}) to prove Theorem [2.5](#FPar7){ref-type="sec"} it suffices to deduce the convergence to stationary states for the singular component $\documentclass[12pt]{minimal}
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                \usepackage{amsmath}


doing it “by hand”. Computers are great at math and automation, but extracting context is a bit more difficult for my silicon friends (and also for my silicone friends). The human mind can be far better at these tasks, at least some minds. The way you have to think is in making connections. One bread crumb of data leads to another, which leads to another and then another. For example: Finding a user name leads to other profiles with more data, this leads to a full name, then this could lead to a physical address.

A user name can lead to pics, which could lead to license plates or physical addresses.

For common names like John Doe adding interests from a profile or a location can lead to narrowing downshared IP. It’s nice to have them do some of the recon for you if you don’t want to use a proxy and don’t wish for your IP to show up in the target’s logs.

http://serversniff.net

Looking for profiles on a person

OSINT BOOKMARKLETS v0.2

http://illmob.org/bookmark.html

Cool page from Will Genovese where you can lookup Phone, IP, Host, Email, S/N, Name, and Address info in an automated fashion. True People Search

https://www.truepeoplesearch.com

Awesome site for finding addresses and mapping out family relations. Family Tree Now

http://www.familytreenow.com

Awesome site for finding addresses and mapping out family relations. Moose Roots

http://www.mooseroots.com

Awesome site, especially for these sub-sites

http://birth-records.mooseroots.com/

http://marriage-divorce-records.mooseroots.com/

which are great for mapping out family relations for password reset questions. Advanced Background Checks

For finding street addresses and relatives this is the bomb. So far, it has not failed me on finding street addresses


dominates everywhere in Europe?

Jacek Saryusz-Wolski: We should avoid this kind of arrogance like Macron’s saying that we want to be a leader, that we have the right recipe for Europe.

I think in fact that the Polish economics and social model, with growth, very low unemployment, social solidarity, is a good answer and an alternative to the rather confused model of Western Europe. Formally, Poland does not claim to say “follow us, we alone have a recipe for Europe”, but I think that Central Europe, the Visegrad group, is a group of countries that in fact demonstrates Western Europe that another way exists.

Contrary to what is often said in the Progressive Liberal circles of Western Europe, we are very anxious to preserve and defend Europe, its borders, its achievementsa recent study conducted by the University of Michigan Transportation Research Institute, people are switching to SUVs and pickups because these vehicles offer greater general utility and better on-road 4×4 capabilities and are safer.

Meanwhile, low gas prices, increasing wages, ongoing economic expansion and soaring consumer confidence could mean more Americans are willing to shell out extra cash for a truck or SUV.

Together, these trends indicate that the F150’s reign as king of trucks won’t end anytime soon.

M. Berk Talay, Associate Professor of Marketing, University of Massachusetts Lowell

This article is republished from The Conversation under a Creative Commons license. Read the original article.


characterised our titles for the last 15 years,” said Total War: WARHAMMER Project Lead, Ian Roxburgh. “We’re bringing it to life in a way that nobody’s attempted before.”"

I think I just got a little too excited! Hopefully we'll see some really cool in-game footage sooner or later too.

Warhammer Fantasy lives on!cold. The family was informed about the risk posed by the probable dehydration episodes suffered by the child. The sc route for the desmopressin therapy and a new attempt at gastrostomy were once again recommended.

This advice was not followed, and at the age of 3 years and 5 months, the child was admitted to his local hospital after five days of a new nasal cold. His medical report registered a Glasgow Score of 8, body weight loss of 12%, and 189 mmol/L of serum sodium. After a few hours of saline infusion, he achieved a certain degree of clinical recovery. However, the next day he worsened again, and forty hours after his admittance, he entered into status epilepticus and was transferred to our hospital.

We received a sedated, malnourished child, with an


an abnormal pontine cortico-ventral signal (though not in the central pontine area), and in the right frontal subcortical white matter (though not symmetrical). Therefore, MRI showed no recent myelinolysis, but did evidence an advanced stage of Wallerian degeneration \[[@B12]\]. The lack of images of myelinolysis on MRI does not rule out this diagnosis \[[@B11]\]. However, the measurement of cerebrospinal myelin basic proteins, which are highly elevated from early myelinolysis, would have supported it \[[@B13]\].

All of these images are areas of post-infarction encephalomalacia \[[@B14]\]. Severe hypernatremic dehydration can produce cerebral osmotic edema, causing hypoxemia and multiple foci of hemorrhagic infarction \[[@B14],[@B15]\]. The images of cortical pontine encephalomalacia and the large area of cerebellar liquefaction (Figure [2](#F2){ref-type="fig"}) are long term consequences of the repeated hypernatremic episodes suffered by the patient.

Undernutrition was         _startupTaskService = startupTaskService;
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PLEASE NOTE: This document applies to the HEAD of the source tree

If you are using a released version of Kubernetes, you should
refer to the docs that go with that version.

The latest release of this document can be found
[here](http://releases.k8s.io/release-1.4/docs/devel/flaky-tests.md).

Documentation for other releases can be found at
[releases.k8s.io](http://releases.k8s.io).

--

# Flaky tests

Any test that fails occasionally is "flaky". Since our merges only proceed when
all tests are green, and we have a

    Add new template

    When purchasing through supported device affiliated links you support this site!


like this that have become the standard in Adwords are scarce to be found within Twitter. A few tips to help you out here include setting your daily budget low, manually adjusting the start and end dates of your campaigns, and keeping bids on the lower side of Twitter's recommended bid suggestions -- at least to start.

Overall, Twitter advertising can be a great channel for SMB marketers to build a user base, connect with that base and ultimately drive leads and sales. Just keep in mind that the effort needs to be dedicated, consistent, and a bit creative at times when it comes to account management. Managing Twitter ads on your own is a hands-on job, but is also a job that has the ability to reap significantkit (Bio-Rad, Hercules, CA, USA). The supernatants were heat-denatured in Laemmli sample buffer solution (Bio-Rad), and the samples with protein adjusted to 30 μg were subjected to electrophoresis on 10% sodium dodecyl sulfate--polyacrylamide gel electrophoresis for protein separation. The samples were transferred to a polyvinylidene difluoride membrane (Trans-Blot Turbo Transfer Pack; Bio-Rad) utilizing Trans-Blot Turbo (Bio-Rad). The membrane was rinsed with Tris-buffered saline mixed with 0.1% Tween 20 (TBST, Bio-Rad) and incubated in 3% bovine serum albumin (Bovogen, Essendon, Australia). The membrane was then incubated with rabbit anti-Iba1 polyclonal antibody (1:1,000; Wako, Tokyo, Japan) diluted in TBST with 3% BSA overnight at 4 °C. Then, the horseradish peroxidase-conjugated rabbit anti-rabbit antibody (Jackson Immuno Research, West Grove, PA, USA) was incubated for 2 h at room temperature. Protein binding


using a rectal probe and a heating pad (BWT-100, Bio Research Center, Osaka, Japan). Additional urethane was administered depending on the toe pinch reflex, and the observation of cortical responses was performed under spontaneous breathing. Rats were fixed to a stereotaxic snout frame, and a craniotomy was performed to expose the right somatosensory cortex. We carefully resected the dura matter. After dura resection, RH-1691 (1 mg/mL) in 0.9% saline was applied to the cortical surface for 1 h. Then, the cortical surface was rinsed with saline and covered with 1% agarose (Agarose Low EEO, Sigma-Aldrich) dissolved in Ringer's solution and a glass coverslip. Bipolar enamel-coated copper wire electrodes (diameter = 80 μm) were inserted into the ulnar side of the palm of the left forepaw and hind paw.aligned and activated areas in the control and SCS groups are superimposed. The number of overlapping responses is represented by the density of color. Magenta outlines indicate the overlapping areas in four of six rats. In the right panel, the outlines were merged. Solid and dashed lines indicate control and SCS groups, respectively. (**j**). Comparison of activated areas in response to hind paw stimulation without and with SCS. \**p* \< 0.05. (Student's *t*-test).](ijms-21-02390-g006){#ijms-21-02390-f006}


for various hadronic interaction models [@qgsjet_11; @qgsjet; @sibyll; @epos]. In all three panels the arrows labeled $\sigma_{\rm sys}$ depict the size of the Auger systematic errors.[]{data-label="breakdown_analytic"}](Fig1a "fig:"){width="0.9\linewidth"}]{} [![A comparison of the Monte Carlo and analytic flux results following the emission of Fe nuclei from sources with $E_{\rm Fe, max}=10^{21}$ eV and $\alpha=1.8$, to recent Auger measurements [@Abraham:2009wk; @Unger:2011ry; @Abraham:2010yv]. [**Top panel:**]{} A breakdown of the arriving flux from shells of UHE CR Fe sources. [**Middle and bottom panels:**]{} The arriving flux’s corresponding $\langle X_{\rm max} \rangle$ and $\mathrm{RMS}(X_{\rm max})$ values, which describe the composition. The hadronic model QGSJET 11 [@qgsjet_11] has been adopted for these comparative calculations. The red and blue bands show the range of predictions of the $\langle X_{\rm max} \rangle$ and $\mathrm{RMS}(X_{\rm max})$ values for protons and iron,motivated by our goodness-of-fit results in the previous section.[]{data-label="source_dist"}](Fig3b "fig:"){width="0.9\linewidth"}]{}\

To put these results on a more general footing, we show in Fig. \[source\_dist2\] the alteration to the GOF contour plots as the distance to the nearest source in increased. We find that for both silicon-only and iron-only source scenarios, the 99% C.L. undergoes a rapid decrease in size for minimum source distances in the range $9-27$ Mpc and $27-81$ Mpc respectively. Furthermore, for larger local voids, the remaining $E_{\rm Fe, max}$ values are larger than those typically considered feasible for candidate UHE CR sources. By imposing the constraint that the cutoff energy, $E_{\rm Fe, max}$, sits below $10^{22}$ eV, the subsequent upper limit on the source distance of 60 Mpc and 80 Mpc are found for silicon and iron type source respectively, at the


99% C.L. This reaffirms the result shown in Fig. \[source\_dist\], that a large $\gtrsim$81 Mpc local void in the source distribution would lead to difficulties in finding self-consistent fits to the spectral, $\langle X_{\rm max} \rangle$, and $\mathrm{RMS}(X_{\rm max})$ data of Auger.

We have assumed throughout this work so far that the extragalactic magnetic field strength is negligible. Though the overall flux from the [*total*]{} ensemble of shells does not vary when an isotropic and homogeneous distribution of magnetic fields is introduced, the components arriving from different source shells will change. Furthermore, with an aim to investigate the possibility of a lack of nearby UHE CR sources, it is necessary that we take into account extragalactic magnetic field effects. In the following section we investigate these effects with the aim ofof magnetic turbulence of the form $P(k)\propto k^{-q}$ (where $k=2\pi/\lambda$), for which $q=5/3$ corresponds to a Kolmogorov-type spectrum, $q=3/2$ corresponds to a Kraichnan-type spectrum. This angular (and eventually spatial) diffusion of the particles is treated following a method very similar to that described in [@Aharonian:1994nn], which we refer to as the “delta-approximation” method (described in further detail in Appendix \[turb\_fields\]). A Kolmogorov-type description of the magnetic field turbulence spectrum is assumed here. Ultra-high energy CRs in the simulation were considered to have arrived once they reached a distance of 100 kpc from Earth (this length scale being chosen to be smaller than both the corresponding particle loss length and gyro-radius).

[![A breakdown of the arriving flux from shells of UHE CR Fe emitting sources with an extragalactic magnetic field of strength


For the hard sources spectra motivated in this paper, approximately the same source luminosity density would exist up to the cutoff energy. Thus an average local luminosity per source of $\sim 10^{43}/N_{\rm s}$ erg s$^{-1}$ is required within the local 60 Mpc region, where $N_{\rm s}$ is the number of contributing sources. Such a luminosity is roughly $1/N_{\rm s}$ that of the 20-40 keV X-ray luminosity of local AGN [@Beckmann:2005gs; @Baumgartner:2010], of which $\sim$10 sit within 60 Mpc from Earth. Whether it is reasonable for these local AGN to channel such a large fraction of their non-thermal luminosity into UHE CR flux, and whether a sufficiently enhanced nuclear composition is able to be achieved within their acceleration sites, however, remains unclear [@Pe'er:2009rc; @GopalKrishna:2010wp].

Our results demonstrate that exciting consequences follow from the intermediate-to-heavy nucleiof the energy within the turbulent field is equal to the total energy within the guiding field ($B_{0}^{2}=\sum_{n}\delta B_{n}^{2}$). We describe the turbulence using $50$ isotropic waves, with $10$ waves per decade ([*i.e.*]{} $\lambda_{\rm max}/\lambda_{\rm min}=10^{5}$). The Bulirsch-Stoer method was used to track the particles in the field.

A simplified description of turbulent propagation, however, may also be obtained through a scattering description of UHE CR interaction with the turbulent field. In this description, UHE CR stochastically interact with scattering centers whose density is dictated by the energy density in the turbulence power spectrum at the wavelength matching the gyro-radius of the UHE CR. We refer to this description as the “delta-approximation” case, since it assumes only resonant scattering. The resonant scattering angle of this process is given by $$\Delta


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2.06 (2)     2.8888 (16)   164.5 (19)
  C5---H5*A*⋯O2^iii^   0.953 (19)   2.532 (19)   3.4133 (17)   153.7 (16)

Symmetry codes: (i) ; (ii) ; (iii) .

[^1]: Thomson Reuters ResearcherID: A-5525-2009.

[^2]: Thomson Reuters ResearcherID: A-3561-2009.


All relevant data are in the paper and its Supporting Information files.

Introduction {#sec001}
============

In wild vertebrates, age has a strong influence on an individual's reproductive performances, which typically increase with age before stabilizing at middle age and declining in senescent individuals \[[@pone.0193526.ref001]\]. In particular, young individuals have poorer breeding success relative to middle-aged individuals. Several hypotheses have been proposed to explain the poorer performances of young individuals \[[@pone.0193526.ref001],[@pone.0193526.ref002],[@pone.0193526.ref003]\]. The improvement of performances with advancing age could result from selective processes and progressive disappearance of low quality parents ("the selection hypothesis") and/or from an increased parental investment from older individuals ("the restraint hypothesis"). Furthermore, "the constraint hypothesis" proposes that young individuals have not yet acquired or developed the skills that are required to breed and to cope with environmental constraints\[[@pone.0193526.ref015],[@pone.0193526.ref021],[@pone.0193526.ref022],[@pone.0193526.ref023],[@pone.0193526.ref024]\]). However, the quality of the offspring is certainly a crucial variable to focus on because the fitness of an individual obviously depends on the ability of its offspring to survive and reproduce \[[@pone.0193526.ref020]\]. In most bird species, post-fledging survival is usually much lower than adult survival, and only a small percentage of the offspring produced are able to recruit into the population \[[@pone.0193526.ref025],[@pone.0193526.ref026],[@pone.0193526.ref027]\]. This suggests that only high-quality offspring will survive and benefit to the fitness of their parents \[[@pone.0193526.ref028],[@pone.0193526.ref029]\]. To better assess the influence of age on an individual's performances, one should therefore not only focus on the ability of individuals to breed or produce young, but also on the ability of young to subsequently survive and reproduce \[[@pone.0193526.ref015],[@pone.0193526.ref022],[@pone.0193526.ref023],[@pone.0193526.ref024]\]. However, such an approach is obviously very


\[[@pone.0193526.ref037]\]). Although several studies have shown that developmental conditions can translate into long-term effects on physiology, body condition, behavior \[[@pone.0193526.ref034],[@pone.0193526.ref038],[@pone.0193526.ref039],[@pone.0193526.ref040]\], this is not always the case \[[@pone.0193526.ref036],[@pone.0193526.ref041],[@pone.0193526.ref042]\] and the impact of these long-term phenotypical effects on fitness are often complex and context- or sex-dependent (reviewed in \[[@pone.0193526.ref043]\]). In contrast, telomere length has recently been suggested as a promising molecular tool to assess the quality of the offspring because long telomeres have been directly linked to improved behavior and physiology \[[@pone.0193526.ref044],[@pone.0193526.ref045],[@pone.0193526.ref046],[@pone.0193526.ref047]\]. Moreover, telomere length seems to be mainly determined during the developmental period (reviewed in \[[@pone.0193526.ref044]\]) and contrary to other physiological measurements, telomere length at the end of the developmental period has been convincingly linked to longevity and fitness in captive and wild animals \[[@pone.0193526.ref048],[@pone.0193526.ref049]\].

Telomeres are terminal chromosomal complexesbirds skip breeding each year \[[@pone.0193526.ref075]\].

A 49-years old ongoing mark-recapture program (see \[[@pone.0193526.ref008],[@pone.0193526.ref009],[@pone.0193526.ref073],[@pone.0193526.ref076]\]; Angelier et al., 2010; Nevoux et al., 2007; Pardo et al., 2013 for details on the monitoring protocol) has been conducted on approximately 200 breeding pairs at Cañon des Sourcils Noirs, Kerguelen archipelago, south-western Indian Ocean (50°S, 70°E). At this colony, all chicks have been banded every year since 1980. After fledging, juveniles spend a few years at sea and return to the colony to breed, allowing us to have access to many known-aged breeders. Each year, the bands of all breeding pairs are checked after egg-laying, allowing us to determine the age of both parents for several nests. For a large proportion of birds, the sex of breeders is known from previous studies that


Finally, the DNA was hybridized with a digoxigenin-labeled probe specific for telomeric sequences, incubated with antidigoxigenin-specific antibody, and was visualized with a Chemidoc (Bio Rad). Telomere length was determined using ImageJ by analysing telomere smear densities. Mean telomere length was calculated in a window of 5--30 kb that includes the whole smear \[[@pone.0193526.ref081]\]. Inter CV was 1.76%.

Statistical analysis {#sec006}
--------------------

Because the influence of mean parental age on several demographic and physiological parameters may be non-linear \[[@pone.0193526.ref015],[@pone.0193526.ref072]\], we first conducted preliminary analyses using generalized additive models (GAM, \[[@pone.0193526.ref082]\]) with smoothing splines to investigate the shape of the relationships for female and male offspring between our variables of interest (telomere length and SMI) and mean parental age, i.e. the mean of paternal and maternal ages (e.g. \[[@pone.0193526.ref083]\]). These preliminary analyses showedthat both telomere length and SMI were linearly related to mean parental age (supplementary material Table A in [S1 File](#pone.0193526.s001){ref-type="supplementary-material"}). Therefore, we used linear models (LM) with a normal error distribution to test the relationships between (1) offspring telomere length and mean parental age, (2) offspring body condition and mean parental age, and (3) offspring body size (beak size) and mean parental age. For each model, mean parental age, the year of sampling, the sex of the offspring and their interactions were included as predictor variables. Maternal and paternal age could not be included simultaneously in the models as explanatory variables because they were highly correlated (r = 0.730, F~1,39~ = 35.26, p \< 0.001). Moreover, the sex of parents could not be determined in 10 pairs limiting


two short-lived bird species, the great-reed warbler (*Acrocephalus arundinaceus*, \[[@pone.0193526.ref049]\]) and the white-throated dipper (*Cinclus cinclus*, \[[@pone.0193526.ref068]\]). However, this pattern was not found in other studies: recently, both a negative correlation and no correlation between these two variables were respectively obtained in the Alpine swift (*Tachymarptis melba*, \[[@pone.0193526.ref070]\]) and in the Soay sheep (*Ovis aries*, \[[@pone.0193526.ref071]\]). Therefore, the relationship between telomere length and parental age seems to be species- and/or context-dependent. Because short offspring telomeres have been linked to lower longevity and survival probability in several studies \[[@pone.0193526.ref048],[@pone.0193526.ref062],[@pone.0193526.ref088]\], our results suggest that younger parents produced offspring of lower quality.

How can we explain such an effect of parental age on offspring telomere length? First, heritability of telomere length could explain this pattern if individuals with short telomeres are moreimport { NgModule } from '@angular/core';
import { IonicPageModule } from '../../../../../..';

import { PageThree } from './page-three';

@NgModule({
  declarations: [
    PageThree,
  ],
  imports: [
    IonicPageModule.forChild(PageThree)
  ]
})
export class PageThreeModule {}


move to Real Madrid, and the Spain international will cost significantly more bunce now that the Premier League TV deal secret is out. Arsenal, their coffers swelled from a summer of transfer inactivity, are also keen.

We might be well into September but the The Charlie Austin Saga rolls on. Newcastle United just don’t know when they’re beat, and with the striker now in the last year of his contract, there is a chance that he could be sold for a lot less than Queens Park Rangers’ £15m summer asking price. Steve McClaren bid £10m plus young whippersnapper Rolando Aarons on deadline day, which was rejected, but the same bid in January could force the London club’s hand, as they do not want to lose Austin for free nextLike this on Facebook

50 Best Acoustic Drum Kit Samples

(including lots of great FREE drum samples!)

We all know the big players in the market – BFD, SSD, SD, AD, … But we tried to find some more exotic, less-known drum libraries, samples, sample packs, kits and samplers / drum sampling applications.
Ofcourse, some of you will recognize lot of them, but I’m sure there are names nobody heard of. There’s (as of last update) more than 70 (!) drum sample providers here (hundreds of kits/libraries/bundles) and lots of freebies.This page is being constantly updated, so be sure to check back again

Drumdrops have a great reputation for their live drum tracks. Now they have started releasing Sample Packs. The first kit available is a 1963 Premier Outfits 54 Kit Recorded at


on the same level). 80% were playing at the time, and many involved falls from beds, chairs or nursery furniture etc. Lacerations to the face or scalp accounted for 31% of injuries, 20% had fractures (especially to the forearm) and bruises accounted for 16% of injuries (mainly face and scalp).

Further resources on the pattern of injury in falls can be found here ..

assault and head injury

Close combat stomping

20% of head injuries in patients attending accident and emergency departments in the UK are the result of an assault (Kay and Teasdale 2001), and this often involves blunt force trauma, in the form of a punch and/or kick, to the head/ face.

Injuries caused by kicking and stamping may result in abrasions which may highlight the pattern of the impacting shoe*hrcV* encodes a structural component of the T3SS, and a mutation in this gene is expected to prevent translocation of T3SS-dependent proteins [@pone.0013472-Holeva1].

An *outC* mutant strain A1919 and an *outC*/*hrcV* double mutant strain Ech141 carrying constructs that encode either full-length DspA/E (pDspE-Cya) or the first 315 amino acids of DspA/E (pDspE~315~-Cya) fused to Cya were infiltrated into *Nicotiana benthamiana*, and the concentration of cAMP (picomoles of cAMP per microgram of protein, ± standard errors) was determined 7 h post infiltration. Compared with the cAMP concentration (0.03±0.01) for *N. benthamiana* leaves infiltrated with the T2SS/T3SS double mutant strain Ech141 harboring pDspE-Cya, a significantly higher concentration of cAMP (0.97±0.04; *p* = 0.018, t-test) was observed in *N. benthamiana* leaves infiltrated with the T2SS mutant A1919 carrying pDspE-Cya ([Table 3](#pone-0013472-t003){ref-type="table"}). Similarly, the concentration


phrpL-28a.

An overnight LB culture of *E. coli* BL21 (DE3) containing His~6~-HrpL encoding plasmids phrpL-28a was subcultured into 100 mL of LB broth containing kanamycin. Bacterial cells were grown at 37°C with shaking until an OD~600nm~ of 0.5 was reached. Following addition of IPTG (isopropyl-beta-thio galactopyranoside) to a final concentration of 1 mM, the culture was incubated for an additional 4 h to induce the expression of the *his~6~-hrpL* gene. The bacterial cells were harvested by centrifugation at 22,000×*g*, resuspended in 20 mL of water, and lysed by freezing and thawing. The lysate was sonicated on ice and centrifuged. The insoluble pellet was washed twice with a washing buffer (25% \[wt/vol\] sucrose, 5 mM EDTA, 1% \[vol/vol\] Triton X-100 in phosphate-buffered saline) and suspended in 5 mL of denaturingof 20 µL. Following incubation at 28°C for 20 min, the samples were loaded onto a 6% native polyacrylamide gel and eletrophoresed in 0.5× TBE. The DNA probes were transferred to an N-positive nylon membrane and detected according to the manufacturer\'s protocol of chemiluminescent nucleic acid detection module (Pierce, Rockford, IL)

Construction of *cya* fusion plasmid {#s4j}
------------------------------------

The *cya* fusions were constructed using the Gateway cloning technology (Invitrogen, Carlsbad, CA) as described [@pone.0013472-Schechter2]. In brief, the appropriate PCR products were cloned into the pENTR/SD/D-TOPO vector (Invitrogen, Carlsbad, CA) to create the entry clone. The PCR products were then transferred by recombination into the destination vector, pCPP3234, which contains the *cya* gene without the start codon, to create an in-frame fusion of the target gene *dspA/E* and *cya* generating the constructs


Particular fuel injection systems employ an air-assist system to encourage atomization of fuel that is metered out of a fuel injector into the air intake stream within an air induction device. In order to employ an air-assist system, the fuel injector needs to form operative seals with a plurality of structural members. In particular, the fuel injector needs to form at least one fuel seal and at least one atmosphere seal. The fuel seal being located between the fuel rail and the fuel injector. The atmosphere seal being located between the sub-atmospheric air in an air-assist passage of the air-assist system and the atmosphere air external to the air induction device.
A known manner of forming the atmosphere seal is to provide a face seal on the portion ofthis time," said a statement from his family.

Later in the day, Vincent Mina, Noah's father, released a statement on his son's death.

"We brought our son, brother and friend home today, just not the way we would have wanted and prayed for. Thank You everyone who joined into this platform, of love and support for KEKAI," Vincent wrote on a Facebook page dedicated to finding Mina. "Your kind and loving sentiments meant the world to us, lifting us up every day. Tears flowed for me when I would read ALL of your loving comments."

"So now the time is here to be with [mother] Irene, [sister] Kahanulani and Kekai’s girlfriend Annina, our adopted daughter," he continued. "We ask that you continue to live life to the fullest, in sharing your


Is sexual intercourse a significant cause of haematuria?
To determine whether recent sexual intercourse might be a cause of microscopic haematuria in patients referred to a urological unit following dipstick detection of urinary haemoglobin. Forty-eight volunteers (24 men and 24 women) consented to have heterosexual intercourse with their regular partner, and to provide samples of urine for testing before and from the first void on the morning after intercourse. After appropriate instruction, volunteers tested their own urine for the presence of blood using standard dipsticks. Any volunteer with haematuria either before or after intercourse was offered a standard haematuria assessment. The results were analysed using the chi-squared test. None of the volunteers tested positively for haematuria immediately before sexual intercourse; six of the 24 women (25%), but no men,-2732872?
-4
What is 391 divided by -20349?
-23/1197
Divide 72 by -15960.
-3/665
What is -7992062 divided by 3874?
-2063
-1768528052 divided by 4
-442132013
What is -33055886 divided by -16527943?
2
What is 17999685 divided by 297?
60605
Calculate 27355227 divided by 536377.
51
2706 divided by -4712
-1353/2356
1473258580 divided by 4
368314645
What is -503797 divided by -1924?
503797/1924
Divide 35152 by 2367.
35152/2367
153715 divided by -19
-153715/19
Calculate -281623 divided by -7.
281623/7
Divide 950 by 172853.
950/172853
Divide 611879892 by -1.
-611879892
Calculate 190 divided by 12929.
190/12929
188716685 divided by -31
-6087635
What is 16836514 divided by 12?
8418257/6
Calculate -44996 divided by -2427.
44996/2427
Divide -165188482 by 42022.
-3931
Calculate 97770965 divided by -622745.
-157
Divide -6141 by 524.
-6141/524
44487705 divided by -8897541
-5
What is 0 divided by -2880350?
0
Calculate 51835657 divided by 6089.
8513
Divide -153 by 20457.
-17/2273
What is 172569841 divided by -172569841?
-1
Calculate 382179808 divided by 62224.
6142
What is 20165760 divided by -162?
-124480
14877912 divided by -177118
-84
42 divided by 414979
42/414979
Divide 37878296 by 2.
18939148
Divide 45628803 by 69.
661287
Divide 529093589 by 27847031.
19
What


Q:

format string in javascript

Is it possible to achieve this in javascript?
Here is the format:
1 ITEM1      9.00   0%  9.00
1 ITEM-GET01 8.00   12% 5.00

I would like to create a receipt like layout. I'm using backbone.js so there will be models and collection involve.
Also if it were on a table can I use jquery to get the data from the table tr then have the result just like what is posted above?
I was able to read about sprintf but I don't think it it is the one I need. any ideas?
UPDATE
I'm trying out sprintf here is what i've come so far
var result = sprintf("%d %-s %.2f %d%% %.2f", model.get("Qty"), model.get("Itemname"), model.get("Price"), model.get("Discount"), model.get("ExtPrice"));

result is:
1 Item1 1.49 0% 1.49

A:

Read this article tothe British team negotiating the deal, says that it might be possible to get an agreement from Iran not to develop an intercontinental-range ballistic missile (ICBM) capable of hitting America. An ICBM, he points out, only makes sense if it carries a nuclear warhead, so testing one should prompt broad economic sanctions. Patricia Lewis of Chatham House, another London think-tank, believes that the Europeans may already be talking to the Iranians about a future regional missile-deal that would ban long- and intermediate-range nuclear missiles.

On inspections, Sir Simon believes that the existing regime is more than adequate. But the E3 could reach clearer understandings with the Americans: about the instructions given to national intelligence agencies monitoring Iran’s nuclear programme; and about how they would jointly deal with Iranian obfuscation


game” and will want to “delegitimise US sanctions” in the eyes of China, Russia and most of Asia by sticking to its obligations. The Iranians may also calculate that if they swiftly crank up their nuclear programme, they would give the White House and Israel cause to threaten military action and Saudi Arabia the excuse to start enriching uranium. (Ironically, both the Saudis and the Israeli security establishment, despite their public opposition to the Iran deal, would these days probably prefer it to survive.)

Stuck in the middle with EU

Mark Fitzpatrick of the International Institute for Strategic Studies hopes that Mr Trump, having quit the deal, might cut the Europeans some slack and not enforce secondary sanctions. Ms Geranmayeh agrees that is possible but thinks it more likely thatmay be used by beliefnet.com in accordance with the agreements.

Previous Posts

More blogs to enjoy!!!Thank you for visiting Dadequate. This blog is no longer being updated. Please enjoy the archives. Here is another blog you may also enjoy:
Letting Go With Guy Finley
Happy Blogging!!! ...

Closing the Door on DadequateAs of this post I'm shutting down my Dadequate blog. It's been less than half a year since my first post here, but it's time to move along to other projects.
Nothing dramatic -- I'm not quitting fatherhood or anything. But I've had a really ...

The Crazy Physics of Starling FlightSorry for the paucity of posts this week and last. I've been knee-deep in my next book and am facing a self-imposed deadline.
In the meantime, check out this video of a flock of


<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE TS>
<TS version="2.1" language="hu" sourcelanguage="en">
  <context>
    <name>ScriptingTcl</name>
    <message>
      <location filename="../scriptingtcl.cpp" line="411"/>
      <source>No database available in current context, while called Tcl's '%1' command.</source>
      <translation type="unfinished">No database available in current context, while called Tcl's '%1' command.</translation>
    </message>
    <message>
      <location filename="../scriptingtcl.cpp" line="433"/>
      <source>Invalid '%1' command sytax. Should be: %2</source>
      <translation type="unfinished">Invalid '%1' command sytax. Should be: %2</translation>
    </message>
    <message>
      <location filename="../scriptingtcl.cpp" line="445"/>
      <location filename="../scriptingtcl.cpp" line="576"/>
     contamination by blood-splash occurs in 50% of cardiothoracic operations. In the Italian Surveillance (SIROH), a total of 987 percutaneous and 255 mucocutaneous exposures were reported in the cardiac setting; most occurred in cardiology units (46%), and in cardiovascular surgery (44%). Overall, 257 source patients were anti-HCV+, 54 HBsAg+, and 14 HIV+. No seroconversions were observed. In the literature, 14 outbreaks were reported documenting transmission of HBV from 12 infected HCWs to 107 patients, and 2 cases of HCV to 6 patients, during cardiothoracic surgery, especially related to sternotomy and its suturing. The transmission rate was estimated to be 5% to 13% for HBV, and 0.36% to 2.25% for HCV. Strategies in risk reduction include adequate surveillance, education, effective sharps disposal, personal protective equipment, safety devices, and innovative technology-based


backlog_default_url: null
  opts:
    description: |
      Base URL for prefixing the features and epics.

      e.g. "https://example.com/"

      Can be empty.
    is_expand: true
    is_required: true
    title: Default URL for the backlog system
- opts:
    description: |
      Project prefix to search for features and epics.

      e.g. "PROJ-"

      Can be empty.
    is_expand: true
    is_required: true
    title: Project prefix
  project_prefix: null
outputs:
- FEATURES_FROM_COMMITS: null
  opts:
    description: |
      If the backlog_default_url isTrudeau -- in office from 1968 to 1979 and 1980-1984 -- made it clear that fellow world leaders had great respect for Carter on nuclear and non-proliferation issues due to his pre-White House work in the nuclear field.

In his inaugural address, Carter said he would work towards the goal of ridding the Earth of nuclear weapons, and it is a quest he continues today as a former president.

While in the White House, Carter signed the SALT II nuclear arms limitation agreement with the Soviet Union. According to his memoir, "Keeping Faith," he also asked that Vice President Walter Mondale receive full briefings on his possible role in a nuclear exchange and was shocked to learn that no previous second-in-command had been so informed. "It was obvious to me


that ... the president might be incapacitated and (the vice president) had to be fully qualified to assume his duties."

As the Japanese workers struggle in their dangerous work, there's no doubt Jimmy Carter's thoughts and prayers have been directed their way. Unlike most of us, he truly understands their fears.

The opinions expressed in this commentary are solely those of Arthur Milnes.a group including defensive coordinator Romeo Crennel, linebackers coach Mike Vrabel and special-teams coordinator Larry Izzo.

"There is nothing easy about this game for our offense. We're going to have to go grind it out. We have to go get our mind right, and we will. We had a good week of practice last week, and we need to carry it over into today -- and all the way through Saturday night."


numbers of those disqualified in court to help them easily identify people suspended from driving.

Over the limit

Drink driving convictions

Jan 2013-May 2015

Co Kerry courts had the lowest conviction rate, at 29 per cent. In Cahirciveen, six convictions resulted from 40 cases; in Kenmare the figure was 11 out of 40. And of 168 cases before Listowel District Court, 44 ended in conviction.

The highest conviction rate was in Offaly, at 68 per cent.

In Castlerea, Co Roscommon, 68 people were listed over the 2½ years; only seven were convicted. And of 21 cases listed in Cill Rónáin District Court, on Inishmore, Co Galway, there was only one conviction.

In Ballyhaunis, Co Mayo, eight people were due before the courts for the offence in 2013. There were no convictions. The court has sincethe penalty point system.

“We believe that this must include a root and branch examination of how the courts and the RSA follow up on the good work of An Garda Síochána,” she said. “We also call for a consolidation of the Road Traffic Acts to make it easier to follow and less prone to loopholes.”


couple of the more annoying bugs that would infrequently pop up in regards of stamina regen and agro generation. These fixes will benefit both PVE and PVP.

Animation and Combat updates

There has been a couple of long standing inconsistencies with the way the animation system interacts with combat calculations that some players have used to their advantage. The team have made some changes here to prevent this, and to give us a sounder basis on which to make further changes in the future, should they be required. This will go to the live server in the same update as the adventure pack content.

Targeting Changes

This is a minor change, but another cosmetically small one that should be helpful in PVP. Currently your team-mates and a player target you haven't yeta first time. In a pledge sure to raise eyebrows on Wall Street, he said he'd block a potential merger between AT&T and media conglomerate Time Warner.

Translating his proposals into digestible bullet points, he offered to-the-point titles for the legislative vehicles he'd need Congress to approve to accomplish his goals, such as the "End Illegal Immigration Act" and the "Repeal and Replace Obamacare Act."

Throughout the GOP primary, Trump was criticized for shying away from detailed policy proposals. But his speech, which aides said would form the core of his closing argument to voters, underscored how the billionaire has gradually compiled a broad -- if sometimes vague -- policy portfolio that straddles conservative, isolationist and populist orthodoxies.

Trump didn't say what kind of lawsuits he planned to file against the


of many communities where we build in the Hill Country. River Hills offers free on site analysis of building costs that are specific to each individual lot. Once an overall cost to build is agreed upon, our team can assist your purchase of the land with no obligation to build.having higher concentrations of blood alcohol tended to be sent to treatment. Use of the MOD-CRIT assessment instrument provides the state alcohol treatment system with a means by which drinking drivers can systematically be referred to appropriate rehabilitation programs. Although some margin of error may exist during the assessment process, mandatory assessment is deemed preferable to individualized reports that are open to bias and interpretation.


I've ranked every farm system, as well as the top 100 MLB prospects for 2015. Now it's time for each team's top 10 prospects, but I've also added:

• Overview: A look at each system with names well beyond the top 10

• Impact: Prospects who might help the big league club in 2015

• Fallen: One or two prospects whose stock has taken a big hit in the past year

• Sleepers: A player or two who could jump into the main top 100 list in 2016

Each team's farm system ranking is in parentheses.

AL East

Tampa Bay Rays (23) (The Rays article is free to non-Insiders)

Baltimore Orioles (22)

Boston Red Sox (5)

New York Yankees (20)

Toronto Blue Jays (19)

AL Central

Chicago White Sox (12)

Cleveland Indians (16)

Detroit Tigers (30)

Kansas City Royals (15)

Minnesota Twins (2)

AL West

Houston Astros"gift" within the prohibition of section 3 of the act. By answer and affidavit petitioner admitted the use of trading stamps in his business, but denied that they constitute a "gift," or that they are issued in violation of either the spirit or the letter of the act, or for the purpose of injuring competitors, or destroying competition.
 On February 25, 1941, the trial court granted a preliminary injunction directing petitioner to refrain, pending a final determination of the cause, from directly or indirectly "(a) Giving away, or offering or advertising the intent to give away, any article, or product, or commodity, or thing or things of value, or any stamp, or coupon, or certificate redeemable in or exchangeable for any thing or things of value, or any


our backs inside then, so it might be easier to look at a vintage case where a does not support promises (takes callbacks), and we don't flatten things correctly:
// Old times and unflattened for exposition:
new Promise((resolve, reject) => a(function(result) {
  resolve(new Promise(setTimeout));
}, reject))
.then(() => console.log("after setTimeout"))
.catch(e => console.error(e));

Here we see more clearly that resolve is called with another promise. Importantly, the resolved promise does not fulfill and fire the "after setTimeout" message until the second promise resolves (with a non-promise undefined value from setTimeout), at which point both promises become fulfilled (in other words:  these two promises just formed a resolve chain).
This is key to understanding that resolved is different from fulfilled or even settled (fulfilled or rejected, not pending).
From States and Fates:

states: fulfilled, rejected, pending.
fates:Re-making Lego Lego, the tiny plastic bricks that engage young minds and fingers, have clicked with generations of kids. So, why is the popular toy undergoing a remake? Roxana Saberi visits the Lego factory in Billund, Denmark, to find out.


drugs are often different than in adults, side effect profiles vary by age, and ontogeny of the CYP enzymes, particularly for infants, can impact the drug--gene relationship \[[@B16-jpm-07-00014]\]. Furthermore, compared to the body of evidence from studies in adults, there is a paucity of research supporting the use of genotype to guide prescribing in children.

Due to the potential for clinical pharmacogenomic testing and the lack of pediatric specific data, the goals of this manuscript are as follows: first, to use a single-center, longitudinal, electronic health record (EHR) cohort to determine the frequency of pediatric exposures to medications with established interactions with CYP enzymes (i.e., define the number of unique pediatric patients exposed to drugs with CPIC level A or B and PharmGKB level 1 or 2 evidence forserum 9-hydroxyrisperidone, but not with risperidone plasma levels. In another study, children who were CYP2D6 ultra-rapid metabolizers exhibited less weight gain while on risperidone therapy compared to normal metabolizers; however, poor metabolizers showed similar effect to the normal metabolizers \[[@B43-jpm-07-00014]\]. Other studies evaluating the effects of major and minor CYP2D6 inhibitors, rather than *CYP2D6* genotype, on the metabolism of risperidone in children demonstrated a much stronger association of CYP2D6 function to plasma levels of risperidone than with its major metabolite \[[@B111-jpm-07-00014]\]. The Dutch Pharmacogenetics Working Group has recently changed its dosing recommendations of risperidone to "no action is required" for CYP2D6 poor metabolizers. The evidence for the impact of *CYP2D6* variability on the efficacy and adverse effects of risperidone is insufficient to support changes in prescribing based on


to include only those with PharmGKB level 1A, 1B, 2A or 2B evidence and CPIC level A, A/B or B levels.

4.2. Determining the Pediatric Exposures to CYP-Associated Drugs {#sec4dot2-jpm-07-00014}
----------------------------------------------------------------

To determine the number of unique pediatric patients exposed to the actionable CYP-associated drugs identified from the CPIC table, we used the Synthetic Derivative (SD), the de-identified electronic health records database at Vanderbilt University Medical Center. The study was reviewed by the Vanderbilt Institutional Review board and determined to be non-human subjects research. Exposure to the medication of interest was defined as one or more mention of the drug name, in conjunction with a dose, route, strength or frequency, using MedEx \[[@B118-jpm-07-00014]\]. For this study, we restricted mentions to those occurring in the 10-year period from 2006 to 2016. These                    29 (0.8%)       16 (0.4%)       510 (13.9%)            86 (2.3%)                    3124 (84.9%)                     471 (12.8%)
  **12**   paroxetine        3445                   7 (2--15)


35 (3.1%)       5 (0.4%)        128 (11.3%)            92 (8.1%)                    957 (84.6%)                      82 (7.3%)
  **22**   imipramine        877                    11 (8--13)                  solo and then another 100 practicing the next? The more I play, the easier it should be to learn a new solo or arpeggio fast. For that, do I need to learn scales and notes? Because right now, I'm just figuring out stuff using tabs and that's it. Also, instead of practice exercises, I'm learning actual songs that I think are easy enough for me. Because those exercises can get boring and I'm afraid I'll just give up playing.
I know my question seems subjective but I want to practice 'smartly' -- if learning scales and names of notes and stuff is that way, so be it. The ultimate goal is exponential learning rather than linear learning so that I can pick up on new solos or arpeggios faster.
P.S.


I can't afford guitar classes, so I'm on my own and you are all I've got.

A:

I empathise with you. For years, I played like that. Each solo was learned individually. Then it was realised that some players tended to use the same set of notes in a lot of their solos. For instance, pentatonic minor. Once it was realised that the sound of that scale was distinctive, I could recognise the sound of the same set of notes in other solos.So, instead of searching up and down, a fret at a time, for the next note, it became obvious that some of those notes I played in trying to find the matching ones just wouldn't be in the solo. So, lots of time and effort saved.
That's a simplifiedand min. blues, full major, natural and harmonic minors,will get you an awesome way down the playing path.
Simple idea - learn major pentatonic, in any key, preferrably not using open strings, and try to play Amazing Grace, just using those notes. Clue - it starts on the fifth of the scale, not the root. The fifth is one string lower than the root, on that same fret. Then try it in the other 11 keys. And if that's too easy, try the solo in Stevie Wonder's Sir Duke. Same notes, with just a couple of extras thrown in.


Impacts of sex and exposure duration on gene expression in zebrafish following perfluorooctane sulfonate (PFOS) exposure.
Perfluorooctane sulfonate (PFOS) is a member of the anthropogenic class of per- and polyfluorinated alkyl substances (PFASs), and is one of the most frequently detected PFAS in water, humans, mammals, and fish around the world. The zebrafish (Danio rerio), is a small freshwater fish considered an appropriate vertebrate model for investigating the toxicity of compounds. Previous investigations showed tissue-specific bioaccumulation and alterations in the expression of fatty acid binding proteins (fabps) in male and female zebrafish, potentially due to interactions between PFAS and fatty acid transporters. In addition, a number of neurological impacts have been reported as a result of human and animal exposure to PFAS. Therefore, this comprehensive study was designed toinvestigate whether PFOS exposure affects the expression of genes associated with fatty acid metabolism (fabp1a, fabp2, and fabp10a) in zebrafish liver, intestine, heart, and ovary and genes involved in the nervous system (ChAT, ngf, bdnf, AChE, and hdac6) in brain and muscle. Results indicate alterations in expression of genes associated with fatty acid metabolism and neural function that vary with both exposure concentration and sex. Additionally, our findings highlight that the expression of these genes differ according to exposure duration. Our results extend the knowledge base on PFOS effects to other tissues less often studied than the liver. The findings of this investigation provide a basis for future studies on the potential risks of PFOS as one of the most abundant PFAS in the environment. This article is


In the case of fossil-fuel-fired power plants for generating electricity, a carbon dioxide-containing flue gas is formed through the combustion of a fossil fuel. In order to prevent or decrease carbon dioxide emissions, carbon dioxide must be separated from the flue gases. In general, various methods are known for separating carbon dioxide from a gas mixture. In particular, the absorption-desorption method is usually employed for separating carbon dioxide from a flue gas after a combustion process. On an industrial scale, carbon dioxide is washed out of the flue gas using an absorbent.
The usual chemical absorbents, for example monoethanolamine (MEA), display good selectivity and a high capacity for carbon dioxide CO2. However, amine solutions as detergents also bind, irreversibly, acidic minor constituents of flue gas such as nitrogen dioxidethrough contact with the hot flue gas, amines are discharged in small amounts with the purified flue gas into the environment, which can lead to undesirable air pollution. Moreover, distillation-based purification techniques require a high energy expenditure, and per mole of separated sulfite or sulfate, two moles of the active substance remain in the residue, which must be further processed or disposed of.
Therefore, in this respect salts of amino acids for example are particularly suitable for scrubbing CO2 flue gas, as solutions of salts of amino acids do not have a measurable vapor pressure and therefore cannot be discharged with the flue gas. However, for this reason distillation-based processing is also not possible with solutions of salts of amino acids. To prevent blocking of the salts of amino


all the time with foreign policy.” Mulvaney later walked back his remarks by saying in a statement there was “absolutely no quid pro quo between Ukrainian military aid and any investigation into the 2016 election.”

So far Mulvaney has refused to testify, but Sondland will appear for a public hearing on Wednesday and is expected to be grilled about his conversations with Mulvaney and Trump. Hill will also likely be asked about Mulvaney’s role in freezing Ukraine aid when she appears before Congress on Friday. Mark Sandy, a senior career official at the Office of Management and Budget, testified to House investigators behind closed doors on Saturday, and a transcript of his testimony is expected to be released in the coming days. Other senior officials have refused to testifythat all lie in one component of $T \setminus v$.

The first condition is actually a consequence of the second, but we stated it separately for clarity. It will be useful to note that the second condition also implies that if $e$ is an edge incident to $v$, then $\ell(v)$ is missing labels from at most one component of $T\setminus e$. Figure \[fig-fully-labelled\] shows an example of a tree with a proper labelling.

Let $e$ be an edge with endpoints $x,y$. We call that edge *fully-labelled* if $\ell(x)\cup \ell(y) = A$, i.e., if the edge contains all labels. The proper labelling in Figure \[fig-fully-labelled\] has a fully-labelled edge. This motivates the statement of our main theorem, which may be viewed as an analogue of Sperner’s lemma for trees:

\[thm:sperner-tree\] Let $T=(V,E)$