Conditions: Solid Tumor Unresectable or Metastatic Melanoma
Keywords: Combination ipilimumab Cancer checkpoint inhibitor PD-L1 CTLA-4 PROCLAIM PROCLAIM-CX-072 Relapsed Refractory
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 3
Healthy volunteers: no

Brief summary:
To obtain evidence of antitumor effect of CX-072 in combination with anticancer therapy in adult patients with solid tumor based upon overall response rate by Response Evaluation Criteria in Solid Tumors (RECIST)

Detailed description:

Arms:
arm 1: histologically or cytologically confirmed solid tumor who have received no prior treatment arm 2: histologically or cytologically confirmed Stage III (unresectable) or Stage IV melanoma who have experienced progressive disease or relapse following treatment with a PD-1/PD-L1 immune checkpoint inhibitor arm 3: histologically or cytologically confirmed, advanced/unresectable or metastatic solid tumor that have experienced disease progression during or following treatment with platinum based therapy arm 4: neo-adjuvant study in subjects with histologically confirmed solid tumor

Interventions: intervention 1: CX-072 intervention 2: Ipilimumab
Intervention descriptions: intervention 1: CX-072 in combination with ipilimumab intervention 2: CX-072 in combination with ipilimumab

Protocol document:
Prot_000.pdf: 
CTMX-M-072-002 
A Phase 2, Open-Label, Multi-cohort Study of PD-L1 Probody™ Therapeutic CX 072 in 
Combination With Other Anticancer Therapy in Adults With Solid Tumors (PROCLAIM-CX-072) 
NCT# 03993379 
21/August/2019 


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