Conditions: Breast Cancer
Keywords: ER+ PR+ Human Epidermal Growth Factor Receptor (HER) 2 negative metastatic
Allocation: NON_RANDOMIZED | Intervention model: SEQUENTIAL
Enrollment: 68
Healthy volunteers: no

Brief summary:
The study drug cabozantinib works by inhibiting several different proteins which are believed to be involved in breast cancer tumor growth, its ability to spread, and its ability to form new blood vessels. This drug has been used in other research studies and information from those other research studies suggests that this drug may help to prevent cancer growth.

The single agent portion of this study is now closed to accrual. This research study is now examining the efficacy of cabozantinib in combination with fulvestrant for treatment of hormone-receptor-positive breast cancer that has spread to bone.

Detailed description:
Cabozantinib will be taken orally once a day in cycles of 28 days (4 weeks). Fulvestrant will be given intramuscularly on days 1 and 15 of cycle 1 and on day 1 of all subsequent cycles.

On Day 1 of each cycle subjects will have the following tests and procedures:

* Performance status
* Physical exam
* Vital signs
* Routine blood samples
* Blood and urine samples to look at bone markers (Cycle 1 through 6 only)

Subjects will also have the following additional tests and procedures:

* Tumor assessment by Computed Tomography (CT) scan and bone scan at Cycle 3, then every 12 weeks
* Blood or urine pregnancy test (if applicable) on Day 1 of Cycles 1, 2, 4, then every 12 weeks
* Urine sample and blood test for thyroid function (Cycle 1, 3, 5, then every 6 weeks)
* Blood test for breast cancer tumor marker (Cycle 1 and 4, then every 6 weeks)
* Pain questionnaire and painkiller medication diary at 7-day intervals during Week 3, Week 6, and every 6 weeks thereafter.

Arms:
arm 1: Oral cabozantinib therapy daily arm 2: Combination therapy with oral cabozantinib daily plus fulvestrant monthly Intramuscularly (IM)

Interventions: intervention 1: Cabozantinib intervention 2: Fulvestrant
Intervention descriptions: intervention 1: Given orally daily with a starting dose of 40 mg intervention 2: Given intramuscularly 500 mg on Days 1 and 15 of the first 28 day cycle, then on Day 1 only each cycle after

Protocol document:
Prot_SAP_000.pdf: 
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