Conditions: Urinary Bladder Overactive Urinary Bladder Diseases\Urologic Diseases Overactive Bladder Urgency Incontinence
Keywords: Combination Therapy Mirabegron Overactive Bladder Urgency Urinary Incontinence Nocturia Solifenacin Succinate
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 3527
Healthy volunteers: no

Brief summary:
The purpose of this study was to examine how well two medicines (solifenacin succinate and mirabegron) combined work compared to each medicine alone in the treatment of bladder problems.

Detailed description:

Arms:
arm 1: Participants who received solifenacin 5 mg and mirabegron 25 mg once a day for 12 weeks. arm 2: Participants who received solifenacin 5 mg and mirabegron 50 mg once a day for 12 weeks. arm 3: Participants who received matching placebo once a day for 12 weeks. arm 4: Participants who received solifenacin 5 mg once a day for 12 weeks. arm 5: Participants who received mirabegron 25 mg once a day for 12 weeks. arm 6: Participants who received mirabegron 50 mg once a day for 12 weeks.

Interventions: intervention 1: Solifenacin succinate intervention 2: Mirabegron intervention 3: Placebo to match solifenacin succinate intervention 4: Placebo to match mirabegron
Intervention descriptions: intervention 1: Oral tablet intervention 2: Oral tablet intervention 3: Oral tablet intervention 4: Oral tablet

Protocol document: