Conditions: Septic Shock
Keywords: septic shock hydrocortisone mortality
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 118
Healthy volunteers: no

Brief summary:
The purpose of this study : 1）to determine whether hydrocortisone is effective in the treatment of septic shock and 2) to identify the role of timing of low dose hydrocortisone administration in septic shock patients.

Detailed description:

Arms:
arm 1: Vials containing normal saline as placebo were identical to those containing hydrocortisone. Placebo administration procedures were similar. arm 2: Hydrocortisone was administered 200 mg/d as a continuous infusion for 6d, then tapered off. Once all vasopressors were discontinued, the taper protocol was initiated (half dose for three days, then quarter dose for three days and then stopped).

Interventions: intervention 1: Hydrocortisone intervention 2: saline
Intervention descriptions: intervention 1: Hydrocortisone was administered 200 mg/d as a continuous infusion for 6d, then tapered off. Once all vasopressors were discontinued, the taper protocol was initiated (half dose for three days, then quarter dose for three days and then stopped). intervention 2: Vials containing normal saline as placebo were identical to those containing hydrocortisone. Placebo administration procedures were similar.

Protocol document: