Conditions: Kidney Disease
Keywords: uric acid kidney disease endothelial dysfunction
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 80
Healthy volunteers: no

Brief summary:
This study will test the hypothesis that uric acid impairs the function of vessels in patients with kidney disease

Detailed description:
The purpose of the study is to understand the effect of lowering serum uric acid levels on vascular function in individuals with chronic kidney disease by comparing the effects of:

1\) Allopurinol therapy and 2) Placebo.

Patients will receive: 3 month study drug (either allopurinol or placebo), with assessment of serum uric acid levels and vascular function.

Arms:
arm 1: Patients who are randomized to this group will received placebo tablets. Placebo tables do not contain an active ingredient. This group will be used as a baseline group to compare the effects of lowering uric acid on vascular function. arm 2: Patients who are randomized to this group will receive allopurinol tablets. Allopurinol is a medicine that lowers uric acid levels. The effects of lowering uric acid on vascular function outcomes will be assessed and compared to the control group.

Interventions: intervention 1: Allopurinol intervention 2: Placebo
Intervention descriptions: intervention 1: Xanthine oxidase inhibitor- effective at lowering uric acid levels. intervention 2: Placebo tablets with no active ingredient

Protocol document: