Conditions: Alcoholism
Keywords: N-acetylcysteine naltrexone
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 111
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine whether: (1) the combination of N-acetylcysteine + high-dose naltrexone (150 mg) works better than high-dose naltrexone (150 mg) alone in reducing alcohol drinking; and (2) high-dose naltrexone (150 mg) alone works better than low-dose naltrexone (50 mg) alone in reducing alcohol drinking.

Detailed description:
The 3 groups (N-acetylcysteine plus naltrexone 150 mg, naltrexone 150 mg, and naltrexone 50 mg) will be compared in a 12-week randomized, double-blind clinical trial.

Arms:
arm 1: N-acetylcysteine + high-dose naltrexone (150 mg) arm 2: High-dose naltrexone (150 mg) alone arm 3: Low-dose naltrexone (50 mg) alone

Interventions: intervention 1: N-acetylcysteine + high-dose naltrexone (150 mg) intervention 2: High-dose naltrexone (150 mg) alone intervention 3: Low-dose naltrexone (50 mg) alone
Intervention descriptions: intervention 1: All subjects will be evaluated weekly for 12 weeks. intervention 2: All subjects will be evaluated weekly for 12 weeks. intervention 3: All subjects will be evaluated weekly for 12 weeks.

Protocol document: