Conditions: Keratosis, Actinic
Keywords: Actinic keratosis
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 14
Healthy volunteers: no

Brief summary:
The purpose of this study is to evaluate the potential for systemic exposure of aminolevulinic acid (ALA) and protoporphyrin IX (PpIX) when applied topically under occlusion, in a maximal use setting in patients with multiple actinic keratoses (AK) involving the upper extremities.

Detailed description:

Arms:
arm 1: 20% aminolevulinic acid applied via Kerastick to individual AK lesions on the upper extremities and covered with occlusive dressing for 3 hours prior to BLU-U treatment

Interventions: intervention 1: Aminolevulinic Acid (ALA) intervention 2: BLU-U
Intervention descriptions: intervention 1: 20% ALA applied to upper extremities for 3 hours prior to 10 J/cm2 blue light intervention 2: 10 J/cm2 of 417 nm blue light delivered at 10 mW/cm2

Protocol document: