Conditions: Breast Cancer
Keywords: Digoxin
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 6
Healthy volunteers: no

Brief summary:
The purpose of this study is to learn what effects digoxin (DIG) may have on human breast cancer tissue.

Detailed description:
Breast cancer cells grow in a low oxygen environment called hypoxia. The body normally controls the amount of oxygen in cells with what is known as Hypoxia-inducible factor (HIF)-1. HIF-1 helps cancer cells grow in low oxygen environments; therefore, if this function can be blocked, it may make it harder for breast cancer cells to grow. Digoxin is a drug that has been shown to block HIF-1 in lab studies. The investigators want to learn if it blocks HIF-1 in human breast cancer tissue. This will be done by comparing the tumor tissue from the original diagnostic biopsy to tissue that is taken at the time of surgery. The investigators will also be comparing tumor tissue of patients who are not randomized to take digoxin.

Arms:
arm 1: Digoxin administration for 2 weeks prior to surgery. arm 2: Group of participants who will not receive digoxin; however, tissue will be collected at time of definitive breast surgery.

Interventions: intervention 1: Digoxin
Intervention descriptions: intervention 1: Digoxin once daily for 2 weeks prior to definitive breast surgery.

Protocol document: