Conditions: Atopic Dermatitis
Keywords: Atopic dermatitis Oregano Atopic Dermatitis Quick (ADQ) score Eczema Area and Severity Index score Reflectance confocal microscopy
Allocation: RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 1
Healthy volunteers: no

Brief summary:
This study is designed to evaluate and compare the efficacy of 3% oregano extract ointment prepared in aqueous solution versus 1% hydrocortisone ointment, a standard treatment, in decreasing the inflammation associated with mild to moderate atopic dermatitis. We plan to recruit 40 patients on the ages comprised between 2 and 17 years old and the study duration for each of the patient is 1 month.

Detailed description:
A single-center, investigator initiated, randomized controlled, double-blind trial will be conducted to determine the effects of an oregano extract in aqueous solution versus 1% hydrocortisone in the treatment of acute-subacute pediatric atopic dermatitis (AD). We suspect that topical oregano will serve as an effective, non-steroidal AD therapy, simultaneously offering extra benefits to pediatric patients as oregano is a natural product with antimicrobial, anti-inflammatory, and antiseptic properties that lacks reports of adverse effects associated with steroids, which children have been noted to be more susceptible to.

Arms:
arm 1: Intervention: hydrocortisone 1% ointment will be applied to one patient's forearm arm 2: Intervention: Oregano extract cream for mild to moderate atopic dermatitis will be applied to the other patient's forearm

Interventions: intervention 1: Oregano extract cream intervention 2: Hydrocortisone
Intervention descriptions: intervention 1: An experimental cream will be applied to one of the arms of the patient which will be an oregano extract and will be compared to the standard treatment which will be hydrocortisone 1% ointment intervention 2: An experimental cream will be applied to one of the arms of the patient which will be an oregano extract and will be compared to the standard treatment which will be hydrocortisone 1% ointment

Protocol document: