Conditions: Ocular Hypertension Open-angle Glaucoma
Keywords: Glaucoma
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 756
Healthy volunteers: no

Brief summary:
Evaluation of the ocular hypotensive efficacy and safety of Netarsudil (AR-13324) Ophthalmic Solution compared to Timolol Maleate Ophthalmic Solution

Detailed description:

Arms:
arm 1: 1 drop AR-13324 in the evening (PM) \& 1 drop placebo in the morning (AM) in both eyes (OU) arm 2: 1 drop twice daily (BID) in the morning (AM) and evening (PM) in both eyes (OU) arm 3: 1 drop AR-13324 twice daily (BID) in the morning (AM) and evening (PM) in both eyes (OU)

Interventions: intervention 1: AR-13324 Ophthalmic Solution 0.02% intervention 2: Timolol maleate Ophthalmic Solution 0.5% BID intervention 3: Placebo intervention 4: AR-13324 Ophthalmic Solution 0.02% BID
Intervention descriptions: intervention 1: 1 drop once daily (QD), PM, OU intervention 2: 1 drop BID, AM/PM, OU intervention 3: 1 drop QD, AM, OU intervention 4: 1 drop BID, AM/PM, OU

Protocol document: