Conditions: Adverse Effects of Angiotensin-converting-enzyme Inhibitors Hypotension
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 59
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine the effects of Angiotension Converting Enzyme Inhibitors (ACE-I) during surgery and in the immediate postoperative period for patients undergoing elective total hip or knee arthroplasty.

Detailed description:

Arms:
arm 1: Subjects randomized to this group will continue their ACE-I through the day of surgery arm 2: Subjects randomized to this group will stop their ACE-I two days prior to surgery (last dose \>48 hours prior to surgery)

Interventions: intervention 1: ACE-I Cessation group intervention 2: ACE-I Continuation group
Intervention descriptions: intervention 1: Subjects stop ACE-I 48 hours prior to surgery. Examples of possible ACE-I drugs include:

benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec, Epaned), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), trandolapril (Mavik) intervention 2: Subjects take ACE-I through day of surgery. Examples of possible ACE-I drugs include:

benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec, Epaned), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), trandolapril (Mavik)

Protocol document: