Conditions: Recurrent or Progressive Glioblastoma
Keywords: glioblastoma
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 35
Healthy volunteers: no

Brief summary:
This clinical trial is a prospective study of radiosurgery treatment for progressive GBM to test 1)the efficacy of radiosurgery for recurrent/progressive GBM compared to chemotherapy , and 2) the role of diffusion-weighted image (DWI) to predict the early tumor progression and treatment response.

Detailed description:

Arms:
arm 1: FRS and Bev followed by Bev combined either Irinotecan or Temozolamide or Carboplatin or Etoposide until progression arm 2: Bev combined either Irinotecan or Temozolomide or Carboplatin or Etoposide until progression

Interventions: intervention 1: Bevacizumab intervention 2: Chemotherapy intervention 3: Fractionated radiosurgery
Intervention descriptions: intervention 1: None intervention 2: None intervention 3: None

Protocol document: