Conditions: Progressive Supranuclear Palsy Corticobasal Degeneration
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 29
Healthy volunteers: yes

Brief summary:
This study will evaluate flortaucipir for brain imaging of tau in subjects with progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and healthy volunteers.

Detailed description:

Arms:
arm 1: Amyloid negative subjects with PSP receiving a flortaucipir PET scan at baseline and at 9 months. arm 2: Amyloid negative subjects with CBD receiving a flortaucipir PET scan at baseline and at 9 months. arm 3: Healthy volunteers receiving a flortaucipir PET scan at baseline.

Interventions: intervention 1: Flortaucipir F18 intervention 2: Brain PET scan
Intervention descriptions: intervention 1: IV injection, 370 megabecquerel (MBq) (10 mCi) intervention 2: positron emission tomography (PET) scan of the brain 75-105 minutes post-injection

Protocol document: