Conditions: Crohn's Disease Inflammatory Bowel Disease
Keywords: Corticosteroid
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 15
Healthy volunteers: yes

Brief summary:
Prospective randomized comparative effectiveness trial designed to compare fixed dosing and weight-based dosing of corticosteroids in patients with Crohn's disease flares.

Detailed description:
* Determine if weight-based corticosteroid (1mg/kg daily) induces remission at a greater rate than fixed corticosteroid dosage.
* Determine if weight-based corticosteroid is associated with greater rate of adverse events than fixed corticosteroid dosage.

Arms:
arm 1: Corticosteroid dose weight-based at equivalent to 1mg/kg prednisone daily. arm 2: Corticosteroid dose fixed at equivalent to 40mg prednisone daily.

Interventions: intervention 1: Corticosteroid
Intervention descriptions: intervention 1: Subjects will receive prednisone orally; if intravenous corticosteroid required initially they will receive methylprednisolone for the first 3-4 days of therapy.

Protocol document: