Conditions: Polycystic Ovary Syndrome
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 166
Healthy volunteers: yes

Brief summary:
The aim of this work is to study the effect of metformin use for reducing early pregnancy loss in pregnant patients with Polycystic ovary syndrome (PCOS).

Detailed description:
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. PCOS produces symptoms in approximately 5 to 10% of women of reproductive age (12-45 years old) and is thought to be one of the leading causes of the female subfertility

* The aim of this work is to study the effect of metformin use for reducing early pregnancy loss in pregnant patients with PCOS
* Research question:

In pregnant women with PCOS, does metformin use decreases the rate of early pregnancy loss?

-Research hypothesis: In Pregnant women with PCOS, metformin may reduce the rate of early pregnancy loss.

Arms:
arm 1: 83 patients will continue metformin until end of 1st trimester (14 weeks gestation) arm 2: 83 patients will stop metformin at diagnosis of pregnancy ( 5-6 weeks gestation)

Interventions: intervention 1: Metformin
Intervention descriptions: intervention 1: 83 patients will continue metformin until end of 1st trimester

Protocol document: