Conditions: Myocardial Blood Flow Reserve
Keywords: PET Lexiscan Regadenoson Rubidium Blood Flow Reserve Myocardial Perfusion Quantitated Myocardial Perfusion
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 80
Healthy volunteers: yes

Brief summary:
The purpose of this study is to evaluate the consistency of quantitative peak stress myocardial blood flow and myocardial blood flow reserve following a 10 second, 1 minute, 2 minute or 4 minute delay in beginning the rubidium-82 infusion post-Lexiscan (regadenoson) injection. It is anticipated that there will be no or minimal difference between the four delay times.

Detailed description:

Arms:
arm 1: A 10 second delay is imposed between the Lexiscan (Regadenoson) injection and start of myocardial perfusion PET imaging. arm 2: A 2 minute delay is imposed between the Lexiscan (Regadenoson) injection and start of myocardial perfusion PET imaging. arm 3: A 4 minute delay is imposed between the Lexiscan (Regadenoson) injection and start of myocardial perfusion PET imaging. arm 4: A 1 minute delay is imposed between the Lexiscan (Regadenoson) injection and start of myocardial perfusion PET imaging.

Interventions: intervention 1: Regadenoson intervention 2: Rubidium-82
Intervention descriptions: intervention 1: Subjects will undergo a rest/Lexiscan (regadenoson) stress myocardial perfusion PET study. intervention 2: Subjects undergo a rest/Lexiscan (regadenoson) stress myocardial perfusion PET study.

Protocol document: