Conditions: Heart Failure
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 60
Healthy volunteers: no

Brief summary:
The RED-HART is a randomized double-blinded placebo-controlled study of Anakinra (IL-1 blocker) in patients with recently decompensated heart failure to determine the safety and efficacy in terms of aerobic exercise capacity and ventilatory efficiency measured with a cardiopulmonary exercise test.

Detailed description:

Arms:
arm 1: Anakinra 100 mg daily for 2 weeks, followed by placebo for 10 weeks arm 2: Anakinra 100 mg daily for 12 weeks arm 3: Placebo injections daily for 12 weeks

Interventions: intervention 1: Anakinra (weeks 1-2) intervention 2: Anakinra (weeks 3-12) intervention 3: Placebo
Intervention descriptions: intervention 1: Anakinra 100 mg daily for weeks 1 and 2 intervention 2: None intervention 3: None

Protocol document: