Conditions: Schizophrenia Schizoaffective Disorder
Keywords: pregnenolone schizophrenia cognitive positive symptom negative symptom placebo control
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 88
Healthy volunteers: no

Brief summary:
This study will investigate adjunctive pregnenolone for patients with schizophrenia and schizoaffective disorder.

Detailed description:

Arms:
arm 1: Pregnenolone arm 2: Placebo

Interventions: intervention 1: Dietary Supplement: Pregnenolone intervention 2: Placebo
Intervention descriptions: intervention 1: Pregnenolone 50mg BID x 14 days, followed by Pregnenolone 150 x 14 days, followed by Pregnenolone 250 mg BID x thereafter for the remainder of the 8-week trial. intervention 2: Placebo

Protocol document: