Conditions: Type 1 Diabetes
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 10
Healthy volunteers: no

Brief summary:
This study will be an open-label, cross-over study as subjects will be studied under both study conditions - suspension of subcutaneous insulin infusion via pump during treatment with insulin alone (control) vs. suspension of subcutaneous insulin via pump during treatment with insulin and canagliflozin.

Detailed description:
The study will consist of 4 visits: an enrollment/screening visit, a control visit with pump suspension prior to treatment with canagliflozin, a visit with pump suspension while on canagliflozin and an end of study visit. Each of the pump suspension visits will be approximately 20-hour overnight admissions to the Hospital Research Unit (HRU).

Arms:
arm 1: Subjects will undergo basal interruption without canagliflozin during an overnight stay on the research unit arm 2: Subjects will undergo basal interruption with canagliflozin during an overnight stay on the research unit

Interventions: intervention 1: canagliflozin intervention 2: basal interruption without canagliflozin
Intervention descriptions: intervention 1: basal interruption with canagliflozin intervention 2: basal interruption

Protocol document: