Conditions: Pain
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 100
Healthy volunteers: yes

Brief summary:
This research study is being done to assess if a combination of medications can enhance the relief of superficial pain (pain at the surface of the skin, such as sunburn pain). The investigators also want to find out if certain genes may be linked to individual differences in experienced efficacy of pain killers. The combination of medications under investigation is diclofenac and atropine. Diclofenac has been approved by the U.S. Food and Drug Administration (FDA) to treat pain. Atropine has been approved by the FDA to treat certain types of poisoning, heartbeat problems, and other diseases but atropine is not approved to treat pain. However, atropine has been used for many years in different European countries to treat painful conditions such as stomach cramps.This research study will compare diclofenac and atropine to placebo.

Detailed description:

Arms:
arm 1: Diclofenac and Atropine combination drug Provided PO. This is a novel combination. Diclofenac 100mg + Atropine 1.2 mg in one single dose arm 2: Placebo capsules will be delivered in same number as the medication

Interventions: intervention 1: Diclofenac and Atropine combination drug intervention 2: Placebo
Intervention descriptions: intervention 1: Diclofenac will be associated with a small dose of atropine 1.2mg intervention 2: For each capsule of active medication, a capsule of placebo will be provided, identical looking.

Protocol document: