Conditions: Pulmonary Disease, Chronic Obstructive
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 304
Healthy volunteers: no

Brief summary:
The primary objectives of the study are to explore the effect of treatment with orally inhaled tiotropium + olodaterol fixed dose combination with and without exercise training, and tiotropium comparing to placebo, on top of behavioural modification in improving exercise capacity in patients with COPD

Detailed description:

Arms:
arm 1: patient will receive placebo once daily, 2 puffs in the morning arm 2: patient will receive tiotropium 5 mcg + olodaterol 5 mcg in fixed dose combination once daily, 2 puffs in the morning arm 3: patient will receive tiotropium 5 mcg once daily, 2 puffs in the morning arm 4: patient will receive tiotropium 5 mcg + olodaterol 5 mcg in fixed dose combination once daily, 2 puffs in the morning

Interventions: intervention 1: placebo to tiotropium + olodaterol intervention 2: tiotropium+olodaterol intervention 3: tiotropium +olodaterol intervention 4: tiotropium
Intervention descriptions: intervention 1: comparator intervention 2: tiotropium 5 mcg once daily intervention 3: olodaterol 5 mcg once daily fixed dose combination intervention 4: tiotropium 5 mcg once daily fixed dose combination

Protocol document: