Conditions: 30% Oxygen Concentration During Colorectal Surgery 80% Oxygen Concentration During Colorectal Surgery
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 5749
Healthy volunteers: no

Brief summary:
Our primary objective is to develop a clinical pathway for care of patients having colorectal surgery at the Clinic. In particular, the investigators would like to determine what intraoperative concentration of oxygen is optimal in our patients.

Detailed description:
The investigators therefore propose to test the primary hypothesis that supplemental oxygen (80% versus 30%) reduces the risk of a composite of surgical sites infection and potentially oxygen-related wound complications. Secondarily, the investigators will assess the incremental cost benefit of 80% versus 30% oxygen. As a safety measure, enough oxygen will always be given to maintain oxygen saturation (as determined by pulse oximetry) ≥95%.

Arms:
arm 1: Inspired oxygen will be maintained at 30%. arm 2: Inspired oxygen will be maintained at 80%.

Interventions: intervention 1: 30% oxygen intervention 2: 80% oxygen
Intervention descriptions: intervention 1: Inspired oxygen will be maintained at 30%. intervention 2: Inspired oxygen will be maintained at 30%.

Protocol document: