Conditions: Colorectal Cancer
Keywords: colorectal cancer zactima
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 109
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine whether treatment with ZACTIMA (vandetanib) in combination with FOLFOX is more effective than FOLFOX alone for colorectal cancer in patients who have failed therapy with an irinotecan and fluoropyrimidine containing regimen.

Detailed description:

Arms:
arm 1: FOLFOX + Placebo vandetanib arm 2: FOLFOX + low dose vandetanib arm 3: FOLFOX + high dose vandetanib

Interventions: intervention 1: Vandetanib intervention 2: FOLFOX regimen=oxaliplatin, fluorouracil, & folinic acid
Intervention descriptions: intervention 1: once daily oral tablet two dose strengths intervention 2: intravenous infusion

Protocol document: