Conditions: Airway Control Anesthesia Intubation Complication
Keywords: Intubation Airway Emergent intubation Rapid sequence intubation Rapid sequence induction RSI Ketamine Etomidate Sepsis Sedative Sedation
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 143
Healthy volunteers: no

Brief summary:
The purpose of this study is to compare the effectiveness and safety of ketamine and etomidate during rapid sequence intubation (RSI).

Detailed description:
This study is a randomized controlled trial of etomidate versus ketamine during rapid sequence intubation (RSI). RSI refers to the process by which patients who require emergency airway management undergo sedation and paralysis prior to insertion of an endotracheal tube(airway tube). Patients who require intubation will be randomized to have intubation performed with either ketamine or etomidate. All other care will be at the discretion of the treating physicians. The purpose of this study is to compare the efficacy and safety of ketamine and etomidate during rapid sequence intubation.

Arms:
arm 1: Subjects in the ketamine arm will receive ketamine for sedation prior to rapid sequence intubation (RSI). arm 2: Subjects in the etomidate arm will receive etomidate for sedation prior to rapid sequence intubation (RSI).

Interventions: intervention 1: Ketamine intervention 2: Etomidate
Intervention descriptions: intervention 1: Subjects will receive ketamine for sedation prior to rapid sequence intubation. intervention 2: Subjects will receive etomidate for sedation prior to rapid sequence intubation.

Protocol document: