Conditions: Alzheimer's Disease
Keywords: Alzheimer's disease ENA713 Chinese patients INSTINCT
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 222
Healthy volunteers: no

Brief summary:
To investigate the efficacy of Exelon capsule at maximal tolerated dose in mild to moderate Chinese AD patients via dosage titration from 3mg/d to 12mg/d in a 16 weeks duration

Detailed description:

Arms:
arm 1: Patients had a dose escalation from 3mg/d to 12mg/d to reach individual tolerated dosage during the titration period of 12 weeks.

Interventions: intervention 1: ENA713
Intervention descriptions: intervention 1: The following strengths of Rivastigmine capsules were provided: Rivastigmine capsule strengths: 1.5mg, 3mg, 4.5mg. The 6mg dose was administered as one 1.5mg capsule and one 4.5mg capsule, and when necessary, the 3mg dose could also be administered as two 1.5mg capsules. Rivastigmine was administered from 3mg/d at baseline. Then dose escalation was made in 3mg/d increments, at a minimun of 4 weeks between dose increases to a maximum dose of 12mg/d or the individual's best tolerated dose.

Protocol document: