Conditions: Chronic Obstructive Pulmonary Disease, COPD
Keywords: COPD, chronic bronchitis, inflammation, airway, LCI, pulmonary function test, lung function, controlled clinical trial, randomized, airflow, smoker
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 92
Healthy volunteers: no

Brief summary:
To evaluate the efficacy, safety and tolerability of multiple doses of QBW251 vs placebo administered orally, on airway function, lung volume, and quality of life in patients with chronic obstructive pulmonary disease (COPD)

Detailed description:

Arms:
arm 1: QBW251 will be provided to participants during 70 days arm 2: Placebo will be provided to participants during 70 days

Interventions: intervention 1: QBW251 intervention 2: Placebo
Intervention descriptions: intervention 1: QBW251 capsule(s) taken orally twice per day intervention 2: Matching placebo capsule(s) taken orally twice per day

Protocol document: