Conditions: Vincristine Induced Neuropathy
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 8
Healthy volunteers: no

Brief summary:
The purpose of this study is to see if a drug called Acetyl-L-Carnitine can help prevent painful nerve damage and nerve pain which is caused by vincristine, a drug used in chemotherapy in children being treated for newly diagnosed ALL. Acetyl-L-Carnitine is a drug available for purchase as a nutritional supplement but for the purpose of this study is experimental.

Detailed description:

Arms:
arm 1: The first 15 subjects participating in this study will receive Acetyl-L-Carnitine and pharmacokinetic testing will be done. arm 2: Subjects 16-30 will be randomized to receive drug or placebo.

Interventions: intervention 1: Acetylcarnitine intervention 2: Placebo
Intervention descriptions: intervention 1: Acetylcarnitine is taken 2 times a day for days 1 through 21. intervention 2: Placebo is taken 2 times a day for days 1 through 21.

Protocol document: