Conditions: Ventricular Premature Complexes Blood Pressure
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 8
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine if reduction in premature ventricular contraction (PVC) burden results in a decrease in blood pressure, sympathetic outflow, plasma catecholamines and an improvement in baroreflex gain. Flecainide will be used for PVC suppression in a randomized, double-blinded, crossover fashion.

Detailed description:

Arms:
arm 1: This arm will undergo attempted PVC suppression using flecainide for 28 days and then undergo no PVC suppression using placebo for 28 days. arm 2: This arm will undergo no PVC suppression using placebo for 28 days and then undergo attempted PVC suppression using flecainide for 28 days.

Interventions: intervention 1: PVC Suppression using Flecainide intervention 2: No PVC Suppression using Placebo
Intervention descriptions: intervention 1: Flecainide will be administered to result in a reduction in PVC burden. intervention 2: Placebo (sugar pills) will be given to result in no alteration in PVC burden.

Protocol document: