Conditions: Gastroesophageal Reflux Disease Systemic Sclerosis Scleroderma
Keywords: gastroesophageal reflux disease heart burn regurgitation systemic sclerosis scleroderma proton pump inhibitor alginic acid omeprazole prokinetic
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 80
Healthy volunteers: no

Brief summary:
The investigators purposes are to define the prevalence of omeprazole resistance gastroesophageal reflux disease (GERD) in systemic sclerosis (SSc), to compare the efficacy of omeprazole in combination with algycon versus omeprazole in combination with domperidone on the severity of reflux symptoms in omeprazole resistant GERD in SSc, and to compare the efficacy of omeprazole in combination with algycon versus omeprazole in combination with domperidone on the frequency of symptoms in omeprazole- resistant GERD in SSc.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Alginic acid intervention 2: placebo (for domperidone) intervention 3: Domperidone intervention 4: placebo (of alginic acid)
Intervention descriptions: intervention 1: Algycon 1 tab chew tid after meal intervention 2: placebo (for domperidone) 1 tab oral tid before meal intervention 3: domperidone (10 mg) 1 tab oral tid before meal intervention 4: placebo (for alginic acid) 1 tab chew tid after meal

Protocol document: