Conditions: Prostate Cancer
Keywords: localized high risk prostate cancer neoadjuvant treatment
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 16
Healthy volunteers: no

Brief summary:
Ixabepilone, 16 mg/m2 or 20mg/m2, weekly x 3, in 4 week cycles, x 4 cycles.

Prostatectomy 2-8 weeks after completion(standard of care and not a part of study)

Detailed description:
Ixabepilone, 16 mg/m2 or 20mg/m2, weekly x 3, in 4 week cycles, x 4 cycles. Prostatectomy 2-8 weeks after completion of chemotherapy (this was standard of care).

This protocol evaluated weekly ixabepilone prior to robotic prostatectomy for patients with high risk localized prostate cancer. PSA response rate, tumor margin status and pathologic responses were assessed.

Arms:
arm 1: Ixabepilone, 16 mg/m2 or 20mg/m2, weekly x 3, in 4 week cycles, x 4 cycles.

Prostatectomy 2-8 weeks after completion \*\*\*this was standard of care and not a part of the study\*\*\*

Interventions: intervention 1: Ixabepilone intervention 2: Prostatectomy
Intervention descriptions: intervention 1: Ixabepilone, 16 mg/m2 or 20mg/m2, weekly x 3, in 4 week cycles, x 4 cycles. intervention 2: Prostatectomy 2-8 weeks after completion \*\*\*this was standard of care and not a part of the study\*\*

Protocol document: