Conditions: Smoking Lapse Behavior
Keywords: smoking lapse behavior smoking cessation varenicline bupropion medication effect on smoking lapse behavior
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 62
Healthy volunteers: no

Brief summary:
The purpose of this study is to examine how smoking cessation medications (varenicline, bupropion) affect the ability to resist smoking and also subsequent ad-lib smoking in non-treatment seeking daily smokers.

Detailed description:

Arms:
arm 1: varenicline 2mg/day arm 2: Bupropion 300mg/day arm 3: Placebo Control

Interventions: intervention 1: varenicline intervention 2: bupropion intervention 3: Placebo
Intervention descriptions: intervention 1: 2mg/day, with 1-week lead-in medication period The starting dose is 0.5 mg/day for days 1-2, followed by 0.5mg twice daily for days 3-5 and then 1mg twice daily for days 4-7. 1mg administered during laboratory session (day 8). intervention 2: 300mg/day, with 1-week lead-in medication period The starting dose is 150mg/day for days 1-3, 300mg/day for days 4-7. 300mg administered during laboratory session (day 8). intervention 3: Placebo

Protocol document: