Conditions: Dent Disease
Keywords: Dent Dents Dent Disease Phosphorus Supplements FGF 23
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 30
Healthy volunteers: no

Brief summary:
Patients with Dent disease have suppressed levels of FGF 23 which contributes to hypercalciuria, kidney stones, nephrocalcinosis and renal failure. Supplementation with phosphorus may reduce hypercalciuria.

Detailed description:

Arms:
arm 1: Dent Disease subjects will receive 2 week supplementation with phosphorus arm 2: Kidney stone with or without phosphate leak subjects will receive 2 week supplementation with phosphorus arm 3: Dent disease subjects will not get phosphorus

Interventions: intervention 1: Phosphorus Supplement intervention 2: Observation
Intervention descriptions: intervention 1: 250 mg po qid intervention 2: Baseline blood and urine measurements only

Protocol document:
Prot_SAP_000.pdf: