Conditions: Healthy Adult Subjects
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 74
Healthy volunteers: yes

Brief summary:
To evaluate the pharmacokinetics safety, and tolerability of single and multiple doses of edaravone solution and suspension in healthy adult males

Detailed description:

Arms:
arm 1: Healthy Japanese male subjects receive a single dose of MT-1186 or matching placebo. arm 2: Healthy Japanese male subjects receive a single dose of MT-1186 or matching placebo. arm 3: Healthy Japanese male subjects receive doses of MT-1186 or matching placebo. arm 4: Healthy Japanese male subjects receive doses of MT-1186 or matching placebo. arm 5: Healthy Japanese male subjects receive a single dose of MT-1186 or matching placebo. arm 6: Healthy Japanese male subjects receive a single dose of MT-1186 or matching placebo. arm 7: Healthy Japanese male subjects receive a single dose of MT-1186 or matching placebo. arm 8: Healthy Caucasian male subjects receive a single dose of MT-1186 or matching placebo. arm 9: Healthy Japanese male subjects receive multiple doses of MT-1186 or matching placebo. arm 10: Healthy Japanese male subjects receive multiple doses of MT-1186 or matching placebo

Interventions: intervention 1: MT-1186 intervention 2: MT-1186-matching placebo
Intervention descriptions: intervention 1: Solution or suspension intervention 2: Solution or suspension

Protocol document:
Prot_000.pdf: 































































































































































SAP_001.pdf: