Conditions: Alcohol Drinking
Keywords: alcohol smoking cessation varenicline bupropion smoking cessation medications
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 60
Healthy volunteers: no

Brief summary:
The purpose of this study is to examine the effect of smoking cessation medications on alcohol drinking. Effect of 2mg/day, 1mg/day, placebo varenicline was evaluated.

Following 7 days of medication pre-treatment to achieve steady state levels, participants complete a laboratory session assessing alcohol self-administration behavior.

Study enrolls heavy drinking smokers (not tested under nicotine deprivation), non-daily smokers, and nonsmokers. Volunteers are administered either varenicline (Chantix) or placebo.

Detailed description:

Arms:
arm 1: varenicline 1mg/day or 2mg/day arm 2: Placebo Controlled

Interventions: intervention 1: varenicline intervention 2: placebo
Intervention descriptions: intervention 1: 2mg/day or 1mg/day with 1-week medication lead-in period. intervention 2: placebo

Protocol document: