Conditions: Diabetes Diabetes Mellitus, Type 1
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 501
Healthy volunteers: no

Brief summary:
This trial is conducted in Europe and the United States of America (USA). The aim of the trial is to compare the safety and efficacy of insulin degludec (IDeg) and insulin glargine (IGlar), both with insulin aspart (IAsp) as mealtime insulin in subjects with type 1 diabetes.

Detailed description:

Arms:
arm 1: Each treatment period consists of a 16-week wash-out period and a 16-week maintenance period arm 2: Each treatment period consists of a 16-week wash-out period and a 16-week maintenance period

Interventions: intervention 1: insulin degludec intervention 2: insulin glargine intervention 3: insulin aspart
Intervention descriptions: intervention 1: Administered once daily, injected s.c. / subcutaneously (under the skin). Dose is individually adjusted. intervention 2: Administered once daily, injected s.c. / subcutaneously (under the skin). Dose is individually adjusted. intervention 3: Administered 2-4 times daily injected s.c. / subcutaneously (under the skin). Dose is individually adjusted.

Protocol document: