Conditions: Diabetes Mellitus, Type 1
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 30
Healthy volunteers: no

Brief summary:
The study will be conducted in participants with type1 diabetes on insulin injection therapy to investigate how the body processes LY900014 and the effect of LY900014 on blood sugar levels. Side effects and tolerability will be documented. The study will be conducted in two parts (Part A and Part B) to achieve its objectives. Participants are expected to enroll in both parts.

Detailed description:

Arms:
arm 1: Individualized doses of LY900014 administered by injection under the skin once in each of 3 periods arm 2: Individualized doses of insulin lispro reference formulation administered by injection under the skin once in each of 3 periods arm 3: Individualized doses of LY900014 administered by injection under the skin immediately before each meal for 14 days arm 4: Individualized doses of insulin lispro reference formulation administered by injection under the skin immediately before each meal for 14 days

Interventions: intervention 1: LY900014 intervention 2: Insulin Lispro
Intervention descriptions: intervention 1: Administered subcutaneously (SC) intervention 2: Administered SC

Protocol document: