Conditions: Forehead Rhytides Glabellar Rhytides
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 421
Healthy volunteers: no

Brief summary:
This is a safety and efficacy study of onabotulinumtoxinA in subjects with forehead and glabellar facial rhytides (frown lines).

Detailed description:

Arms:
arm 1: OnabotulinumtoxinA injected into the protocol-specified areas on Day 1. Subjects will receive at least 1 and up to 3 treatments. arm 2: Placebo (normal saline) injected into the protocol-specified areas on Day 1. If the subject meets the re-treatment criteria in Period 2, the subject will receive up to 2 open-label treatments with onabotulinumtoxinA into the protocol-specified areas.

Interventions: intervention 1: OnabotulinumtoxinA intervention 2: Normal Saline
Intervention descriptions: intervention 1: OnabotulinumtoxinA injected into the protocol-specified areas. Subjects will receive at least 1 and up to 3 treatments. intervention 2: Placebo (normal saline) injected into the protocol-specified areas on Day 1.

Protocol document: