Conditions: End Stage Renal Disease
Keywords: ertapenem pharmacokinetic pharmacodynamics hemodialysis requires hemodialysis three times a week
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 7
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine the amount of ertapenem in the blood over time between hemodialysis session.

Detailed description:
After a hemodialysis session, subject will be administered ertapenem and the amount of ertapenem in the blood will be measured at seven time periods before the initiation of the next hemodialysis session.

Arms:
arm 1: Subjects with end stage renal disease (ESRD) who undergo hemodialysis three times a week and without infection will be administered one gram of ertapenem once over five minutes through infusion access after a hemodialysis session, and will have blood drawn at time 0, 0.5, 1, 2, 6, and 12 hours after the ertapenem administration and once prior to the next hemodialysis session

Interventions: intervention 1: Ertapenem
Intervention descriptions: intervention 1: Subjects are hemodialysis patients who are admitted to Oakwood Hospital - Dearborn

Protocol document: