Conditions: Postoperative Pain Postoperative Nausea Postoperative Vomiting
Keywords: IV Acetaminophen Laparoscopic cholecystectomy Postoperative nausea Postoperative vomiting
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 105
Healthy volunteers: no

Brief summary:
The purpose of this study is to evaluate the use of IV acetaminophen for postoperative pain management after laparoscopic cholecystectomy to determine if its use to supplement standard of care pain management decreases the incidence of post-operative nausea and vomiting.

Detailed description:
The recent clinical development of an intravenous (IV) acetaminophen formulation for use in the US has important implications for the management of postoperative pain given its safety profile and suitability for use in the early phase of the postoperative period. In clinical studies a significant opioid-sparing effect has been documented with a substantial percentage of patients avoiding the need for opioid rescue medication altogether. This avoidance or delay in the use of opioids has been shown to reduce undesirable side effects. It is proposed that the use of IV acetaminophen in the post anesthesia care unit (PACU) for postoperative analgesia after laparoscopic cholecystectomy will result in decreased incidence of post operative nausea and vomiting (PONV) and decreased use of narcotics.

Arms:
arm 1: IV Acetaminophen administered on admission to post-anesthesia care unit arm 2: Standard of care pain management regimen including opioids administered on admission to post-anesthesia care unit

Interventions: intervention 1: IV Acetaminophen intervention 2: Standard of Care
Intervention descriptions: intervention 1: Single dose, 1000g mg infusion over 15 minutes plus standard of care pain management regimen intervention 2: Standard of care pain management regimen, no IV Acetaminophen,

Protocol document: