Conditions: Entropion
Keywords: Anesthesia Agitation Extubation
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 56
Healthy volunteers: no

Brief summary:
The investigators evaluate extubation time and recovery profiles in children undergoing entropion surgery.

Detailed description:
This study will compare the extubation time and recovery profiles (degree of postoperative agitation and cough) between sevoflurane group and desflurane group. General anesthesia will maintained with sevoflurane 2-3vol% or desflurane 6-7vol%. After surgery, the investigators will measure the duration of extubation and recovery profiles between two groups.

Arms:
arm 1: The patients will maintained general anesthesia with sevoflurane. arm 2: The patients will maintained general anesthesia with desflurane.

Interventions: intervention 1: Sevoflurane intervention 2: Desflurane
Intervention descriptions: intervention 1: Intravenous ketamine will administrate to the patients for decreasing of separation anxiety of children.

General anesthesia will maintained with sevoflurane 2-3 vol%. intervention 2: Intravenous ketamine will administrate to the patients for decreasing of separation anxiety of children.

General anesthesia will maintained with desflurane 6-7vol%.

Protocol document:
Prot_SAP_000.pdf: 
ID: 2016-01      
The Effect of Preoperative Ketamine on the Emergence Characteristics in Children Undergoing 
Entropion Surgery      
NCT02916407 
04-25-2019 
We compared the emergence characteristics of sevoflurane versus desflurane with ketamine 
premedicated pediatric patients for ambulatory surgery. The primary outcome was compared the 
extubation time between sevoflurane versus desflurane anesthesia. The secondary outcome was 
compared the emergence characteristics (emergence agitation) between two groups. 
Patients were randomly assigned into group S (sevoflurane) or group D (desflurane). After 
intravenous access in day-surgery unit, ketamine 1mg/kg was administered for separation from their 
parents, and then they were transferred to operating room with monitoring pulse oximetry. General 
anesthesia was maintained with sevoflurane in group S or desflurane in group D.  
Data were analyzed using Medcalc 14.12.0 (MedCalc Software bvba, Ostend, Belgium). 
Parametric variables were described as mean ± standard deviation (SD). Qualitative variables 
were described as number and as median (interquartile range). Student’s t-test, Fisher’s exact 
test, or Mann-Whitney U-test was used as appropriate to compare the two groups. P < 0.05 was 
considered to indicate statistical significant. 
  
Solid PDF Tools
         
 http://www.SolidDocuments.com/