Conditions: Atrophy, Geographic
Keywords: age-related macular degeneration geographic atrophy dry AMD
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 191
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine the safety and efficacy of GSK933776 in the treatment of geographic atrophy secondary to age-related macular degeneration.

Detailed description:
This is a Phase 2a proof of concept study designed to evaluate the safety and efficacy of GSK933776 for the treatment of geographic atrophy secondary to age-related macular degeneration. This is a placebo-controlled parallel-group study that is double masked.

Arms:
arm 1: 3 mg/kg administration of GSK933776 via intravenous infusion arm 2: 6 mg/kg administration of GSK933776 via intravenous infusion arm 3: Placebo via intravenous infusion arm 4: 15 mg/kg administration of GSK933776 via intravenous infusion

Interventions: intervention 1: GSK933776 intervention 2: Placebo
Intervention descriptions: intervention 1: GSK933776 intervention 2: Placebo

Protocol document: