Conditions: Short Stature
Keywords: treatment growth hormone childhood short stature
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 99
Healthy volunteers: no

Brief summary:
The objective was to study whether normal growth velocity can be maintained with adapted GH dosage in GH treated prepubertal children who have responded to GH treatment with fulfilled catch up growth (=difference to target height reached, less than - 0.6 SDS).

Detailed description:
The aim of the trial is to study the effect of adapted GH treatment in order to find an individualized GH dose maintaining normal growth velocity close to target height SDS and normal metabolism after fulfilled catch up growth in prepubertal children treated with individual doses of GH within the trial 98-0198-003 (1). The overall aim is to find for the individual the lowest effective GH dose during maintenance period, maintaining normal growth velocity and metabolism, i.e. a satisfactory biological active dose.

Arms:
arm 1: Unchanged dose Genotropin arm 2: reduced dose 50% Genotropin

Interventions: intervention 1: Genotropin
Intervention descriptions: intervention 1: Children were randomized to either decreased dose by 50% or unchanged dose after 2-3 years of Catch-up growth

Protocol document: