Conditions: Acute Pain Multiple Trauma Fractures
Keywords: pain trauma
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 20
Healthy volunteers: no

Brief summary:
This study will compare ketamine and hydromorphone as alternative patient-controlled interventions for trauma-related pain. Patients receiving ketamine PCA are expected to require less total and breakthrough opioid and to have similar or improved objective pain scores. Patients receiving ketamine are also expected to have shorter duration of supplemental oxygen requirement, fewer episodes of oxygen desaturation, improved pulmonary toilet, lower use of antiemetics, and shorter times to first bowel movement. Ketamine is further expected to be associated with decreased intensive care unit and hospital lengths of stay, faster time to maximum allowable ambulation, decreased opioid dosage at discharge, and lower report of chronic pain syndromes.

Detailed description:

Arms:
arm 1: Ketamine 90mg/30 mL PCA (3 mg/mL) arm 2: Hydromorphone 6mg/30 mL PCA (0.2 mg/mL)

Interventions: intervention 1: Ketamine intervention 2: Hydromorphone
Intervention descriptions: intervention 1: Ketamine administered as patient-controlled analgesia. intervention 2: Hydromorphone administered as patient-controlled analgesia.

Protocol document: