Conditions: Vitamin D Deficiency Pre-Eclampsia
Keywords: Maternal vitamin D Deficiency Insufficiency Pregnancy Pre-eclampsia IUGR
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 179
Healthy volunteers: yes

Brief summary:
Vitamin D deficient pregnant ladies were selected and randomized into 2 groups for routine daily dose of multivitamin (400IU vitamin D3) versus maximum safest treatment daily dose (4000IU vitamin D3). Participants were assessed and compared for number of pre-eclampsia cases.

Detailed description:
Vitamin D3 has key role in decidualization and implantation of placenta.Vitamin D deficiency is thought to have positive association with pre-eclampsia.Vitamin D deficiency is highly prevalent in some parts of the world and it is not universally screened antenatally. Pre-eclampsia is a known multifactorial pregnancy disorder with significant maternal and perinatal morbidity and mortality. Vitamin D3 has a down-regulating effect on inflammatory pathways and reducing endothelial cell damage.

Investigators want to assess in vitamin D deficient group whether treatment reduces the risk of pre-eclampsia.

Arms:
arm 1: 400IU vitamin D3 contained in antenatal multivitamin once daily by mouth starting from 14 weeks of pregnancy till delivery. arm 2: 4000 IU Vitamin D3 drops once daily by mouth starting from 14 weeks of pregnancy till delivery.

Interventions: intervention 1: 400 IU Vitamin D3 intervention 2: 4000 IU Vitamin D3
Intervention descriptions: intervention 1: Antenatal multivitamin intervention 2: 4000 IU Vitamin D3 (cholecalciferol) daily = 40 drops daily

Protocol document: