Conditions: Endometriosis
Keywords: endometriosis chronic pain intravenous lidocaine
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 20
Healthy volunteers: no

Brief summary:
We are doing this research study to find out if intravenous (in your vein, "IV") lidocaine can lessen pain from endometriosis. The U.S. Food and Drug Administration (FDA) has approved intravenous lidocaine to treat irregular heart beats, but the FDA has not approved intravenous lidocaine to treat pain from endometriosis. Intravenous lidocaine has been used for more than 25 years to treat different acute and chronic pain conditions but has not yet been studied for endometriosis pain.

This is a cross-over trial over two months where one month you will receive the active medication (lidocaine) and one month you will receive the active placebo (diphenhydramine, commonly known as benadryl). We will compare the effect on pain from endometriosis of lidocaine to active placebo.

Detailed description:

Arms:
arm 1: IV lidocaine dosed at 8mg/kg IV (maximum 500 mg) and infused over 30 minutes arm 2: IV diphenhydramine 50mg total dosed as a 10mg IV bolus and then 40mg IV infusion over 30 minutes

Interventions: intervention 1: IV Lidocaine intervention 2: IV diphenhydramine
Intervention descriptions: intervention 1: None intervention 2: None

Protocol document: