Conditions: Chronic Obstructive Pulmonary Disease
Keywords: COPD Chronic Obstructive Pulmonary Disease Cyclosporine Oral Immunotherapy Advanced stage
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 43
Healthy volunteers: no

Brief summary:
This is a randomized, double-blinded, placebo-controlled trial of oral Cyclosporine A (CsA) in patients with advanced stage chronic obstructive pulmonary disease. The purpose of the study is to evaluate the safety and effectiveness of CsA as a therapy for the adaptive immune response in advanced stage Chronic Obstructive Pulmonary Disease (COPD).

Subjects between 45 and 80 years of age with a confirmed diagnosis of advanced stage COPD, not responsive to conventional inhaler therapy, who meet all the study requirements, will be enrolled in this study. A total of 30 subjects of either sex will be enrolled in this study.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Cyclosporine intervention 2: Placebo
Intervention descriptions: intervention 1: Fifteen patients will receive cyclosporine at an initial dosing of 3.0 mg/kg/day. intervention 2: Fifteen patients will receive will receive placebo.

Protocol document: