Conditions: Renal Impairment Hepatic Impairment
Keywords: Drug therapy
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 48
Healthy volunteers: no

Brief summary:
The purpose of this study is to examine the effects of renal and hepatic impairment on TAK-272 pharmacokinetics with a single oral administration of TAK-272 in participants with renal or hepatic impairment.

Detailed description:
This study is a phase I, open-label, parallel-group, comparative study to evaluate the effects of renal or hepatic impairment on pharmacokinetics of TAK-272 with a single oral administration of TAK-272 in participants with renal or hepatic impairment as compared with participants with normal renal and hepatic function.

Arms:
arm 1: Fasted single oral administration of TAK-272 40 milligram (mg) arm 2: Fasted single oral administration of TAK-272 40 mg arm 3: Fasted single oral administration of TAK-272 40 mg arm 4: Fasted single oral administration of TAK-272 40 mg arm 5: Fasted single oral administration of TAK-272 40 mg arm 6: Fasted single oral administration of TAK-272 40 mg arm 7: Fasted single oral administration of TAK-272 40 mg arm 8: Fasted single oral administration of TAK-272 40 mg

Interventions: intervention 1: TAK-272
Intervention descriptions: intervention 1: TAK-272 tablet

Protocol document: