Conditions: Diabetes Mellitus, Type 2 Hyperglycemia
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 8
Healthy volunteers: no

Brief summary:
This is a randomized controlled trial to determine the safety and efficacy of Sitagliptin in patients with stress hyperglycemia or mild diabetes following cardiac surgery. Patients will receive Sitagliptin or placebo. Sitagliptin may be of particular use in this patient population due to the effects on hepatic glucose production (a major feature of SH), safety (lack of contra-indications for heart failure or renal failure and no hypoglycemia), and tolerability. The secondary objective of this study is to determine whether the management of patients with persistent insulin requirements following cardiac surgery differs among patients with stress hyperglycemia or mild diabetes.

Detailed description:

Arms:
arm 1: Patients will receive Sitagliptin (renally dosed) prior to hospital discharge and 6 weeks following discharge arm 2: Patients will receive placebo prior to discharge and 6 weeks after discharge.

Interventions: intervention 1: Sitagliptin intervention 2: Placebo
Intervention descriptions: intervention 1: Sitagliptin prior to hospital discharge and 6 weeks following discharge. intervention 2: Patients are reandomized to Sitagliptin or placebo for 6 weeks post-operatively

Protocol document: