Conditions: Gingivitis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 253
Healthy volunteers: yes

Brief summary:
This will be a single-center, 12 week, examiner-blind, randomized, stratified (gender and baseline mean whole mouth MGI score), two-treatment, parallel group, clinical study in healthy adult volunteers with moderate gingivitis. This study will evaluate the efficacy of a dentifrice containing 0.454% weight by weight (w/w) stannous fluoride to control gingivitis and gingival bleeding following 12 weeks twice daily brushing, compared to a negative control dentifrice.

Detailed description:

Arms:
arm 1: Participants will apply a full ribbon of dentifrice containing 0.454% w/w stannous fluoride to the study toothbrush and brush their teeth in their usual manner for one timed minute twice daily (morning and evening) arm 2: Participants will apply a full ribbon of dentifrice containing Dentifrice containing 1000ppm fluoride as sodium monofluorophosphate to the study toothbrush and brush their teeth in their usual manner for one timed minute twice daily (morning and evening)

Interventions: intervention 1: Stannous Fluoride intervention 2: Sodium Monofluorophosphate
Intervention descriptions: intervention 1: Dentifrice containing 0.454% w/w stannous fluoride intervention 2: Dentifrice containing 1000ppm fluoride as sodium monofluorophosphate

Protocol document: