Conditions: Postoperative Nausea and Vomiting
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 705
Healthy volunteers: no

Brief summary:
Double-blind, randomised, parallel-group, placebo-controlled, adaptive, seamless, dose-selecting study to compare the efficacy of APD421 to placebo as treatment of established PONV, in patients who have had prior PONV prophylaxis.

Detailed description:

Arms:
arm 1: Single (standard) dose IV APD421 arm 2: Single (high) dose IV APD421 arm 3: Single IV placebo

Interventions: intervention 1: APD421 intervention 2: Placebo
Intervention descriptions: intervention 1: None intervention 2: None

Protocol document: