Conditions: Sleep Apnea Obstructive Sleep Apnea Postoperative Complications
Keywords: Ketamine Postoperative morbidity
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 9
Healthy volunteers: yes

Brief summary:
The aim of this study is to substantially reduce overall postoperative morbidity and mortality associated with obstructive sleep apnea.

Detailed description:
Obstructive sleep apnea (OSA) affects millions of people in the U.S., and currently, there is not a well-established, general anesthetic technique that clearly decreases the risk of postoperative respiratory complications in these patients. If OSA patients have significantly decreased postoperative opioid requirements and improved recovery profiles in the PACU, the protocol could have significant implications in defining future standardized general anesthesia recommendations for patients with this disease. Ultimately, the aim of this study is to substantially reduce overall postoperative morbidity and mortality associated with obstructive sleep apnea. The objective of this study is to compare the postoperative recovery profile of OSA patients receiving standard Sevoflurane inhaled anesthesia with normal saline infusion versus Sevoflurane combined with a low-dose ketamine infusion.

Arms:
arm 1: OSA patients will receive standard inhaled anesthesia with normal saline infusion arm 2: OSA patients receiving standard inhaled anesthesia combined with a low-dose ketamine infusion.

Interventions: intervention 1: Ketamine intervention 2: Control
Intervention descriptions: intervention 1: OSA patients receiving standard inhaled anesthesia combined with a low-dose ketamine infusion in which dosage will be based on ideal or adjust body weight intervention 2: OSA patients receiving standard inhaled anesthesia combined with normal saline

Protocol document:
Prot_SAP_000.pdf: