Conditions: Heartburn
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 55
Healthy volunteers: no

Brief summary:
The purpose of this pilot study is to investigate the association between gastric acid suppression and relief of 24 hour heartburn following treatment with the proton pump inhibitor (PPI) drug esomeprazole in frequent heartburn patients.

Detailed description:

Arms:
arm 1: Esomeprazole 20 mg administered orally in the morning and placebo administered orally in the evening arm 2: Esomeprazole 20 mg administered orally in the morning and esomeprazole 20 mg administered orally in the evening arm 3: Placebo administered orally in the morning and placebo administered orally in the evening

Interventions: intervention 1: Esomeprazole 20 mg intervention 2: Placebo
Intervention descriptions: intervention 1: Esomeprazole 20 mg banded capsules (22.3 mg esomeprazole magnesium trihydrate) intervention 2: Placebo capsules

Protocol document: