Conditions: Aggressive Periodontitis
Keywords: clarithromycin periodontal debridement aggressive periodontitis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 40
Healthy volunteers: yes

Brief summary:
To assess the periodontal clinical response and the possible adverse effects of the clarithromycin combined to periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis.

Detailed description:
To assess the periodontal clinical response and the possible adverse effects of the clarithromycin combined to periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis.Forty patients were select and randomly assigned into two groups: Group clarithromycin with 20 subjects that received one-stage full-mouth ultrasonic debridement (FMUD) associated with clarithromycin (500 mg - 12/12 hours) for 3 days; group placebo with 20 subjects that received FMUD associated with placebo. Probing depth (PD), gain in clinical attachment level (CAL) and bleeding on probing (BOP) were evaluated at baseline, 3 and 6 months post- operatively.

Arms:
arm 1: 20 subjects that received one-stage full-mouth ultrasonic debridement (FMUD) associated with clarithromycin (500 mg - 12/12 hours) for 3 days. arm 2: 20 subjects that received FMUD associated with placebo (members took with placebo 500 mg b.i.d. for 3 days).

Interventions: intervention 1: Clarithromycin intervention 2: Placebo intervention 3: One-stage full-mouth ultrasonic debridement (FMUD)
Intervention descriptions: intervention 1: Use of 500mg of Clarithromycin twice a day for 3 days intervention 2: Use of placebo tablets twice a day for 3 days. intervention 3: One session of Periodontal debridement using ultrasonic device.

Protocol document: