Conditions: Pregnancy Induced Hypertension Superimposed Preeclampsia Hypertension
Keywords: preeclampsia pregnancy-induced hypertension nicotinamide
Allocation: RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 10
Healthy volunteers: no

Brief summary:
This is a Phase I study of vitamin B3-amide (nicotinamide) dietary supplementation in pregnant women with early onset preeclampsia. The investigators will enroll 10 pregnant women at 24-32 weeks' gestation with the diagnosis of preeclampsia. If the woman is anticipated to remain undelivered for 48 hours after diagnosis she will receive vitamin B3-amide, 500 mg/day given in the morning (n=5) or 1000 mg given in the morning (n=5), continuing until delivery or for 14 days, whichever occurs first. Maternal blood will be collected at baseline and twice a day on days 1, 3, and 7 of nicotinamide administration to measure nicotinamide metabolites, The objectives of this Phase I study are to to test safety of nicotinamide.

Detailed description:

Arms:
arm 1: Nicotinamide 500 mg by mouth each morning until delivery or 14 days, whichever occurs first. arm 2: Nicotinamide 1000 mg by mouth each morning until delivery or 14 days, whichever occurs first.

Interventions: intervention 1: Nicotinamide 500 mg intervention 2: Nicotinamide 1000 mg
Intervention descriptions: intervention 1: Nicotinamide 500 mg taken by mouth each morning intervention 2: Nicotinamide 1000 mg taken by mouth each morning

Protocol document: