Conditions: Teriflunomide Elimination Healthy Volunteers
Keywords: teriflunomide colestipol hcl
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 14
Healthy volunteers: yes

Brief summary:
Primary Objective To determine if colestipol hydrochloride tablets can accelerate the elimination of teriflunomide. Teriflunomide will be administered for 14 days followed by colestipol dosing of 11 days. Total duration of the study is 40 days.

Secondary Objectives To collect information on the pattern of side effects with use of colestipol hydrochloride after teriflunomide administration and to determine the best duration of therapy needed for adequate elimination

Detailed description:
participants will be followed for 40 days to allow for time to administer a loading dose of teriflunomide and observe the elimination of that drug using colestipol hcl.

Arms:
arm 1: None

Interventions: intervention 1: teriflunomide intervention 2: Colestipol
Intervention descriptions: intervention 1: None intervention 2: None

Protocol document: