Conditions: Infertility
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 360
Healthy volunteers: no

Brief summary:
The investigator suggests that local endometrial injury using pipelle catheter performed in the follicular phase (cycle day 5, 6 or 7) of the stimulation cycle may improve the pregnancy rates among patients undergoing intrauterine insemination.

Detailed description:
In a selected group of patients with repeated implantation failure, endometrial injury in the preceding cycle may improve ICSI outcome.

Little is known about the efficacy of this procedure in improving intrauterine insemination outcome.

Also little is known about the effect of this procedure if done in the stimulation cycle weather in ICSI or intrauterine insemination cycles.

Arms:
arm 1: Endometrial injury during ovarian stimulation combined with intrauterine insemination. arm 2: Ovarian stimulation combined with intrauterine insemination.

Interventions: intervention 1: endometrial injury. intervention 2: intrauterine insemination intervention 3: ovarian stimulation
Intervention descriptions: intervention 1: Endometrial injury using a pipelle biopsy catheter on day (5, 6 or 7) of the stimulation cycle combined with the intrauterine insemination. intervention 2: Placement of washed sperm in the uterus using a catheter, around the time of ovulation. intervention 3: Inducing ovulation by human menopausal gonadotrophin ampoules given intramuscular starting from cycle day two, till the leading follicle reaches 16 - 18 mm.

Protocol document: