Conditions: Orthostatic; Hypotension, Neurogenic
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 87
Healthy volunteers: yes

Brief summary:
Compare the effect of treatment of midodrine and pyridostigmine in neurogenic orthostatic hypotension and investigate the quality of life of treatment of neurogenic orthostatic hypotension.

Detailed description:
In patients with neurogenic orthostatic hypotension, the appropriate treatment was identified by comparing the treatment effects and side effects for each treatment drug. In addition, by confirming the effect of orthostatic hypotension on lowering the quality of life, it is expected that the improvement of the quality of life will help.

Arms:
arm 1: Start midodrine 2.5mg bid, and then dose up to 5mg bid after one month if necessary. arm 2: Start Pyridostigmine 30mg bid, and then dose up to 60mg bid after one month if necessary. arm 3: Start midodrine 2.5mg bid+ Pyridostigmine 30mg bid, and then dose up to midodrine 5mg bid+ Pyridostigmine 60mg bid after one month if necessary.

Interventions: intervention 1: Midodrine intervention 2: Pyridostigmine Bromide intervention 3: Midodrine + pyridostigmine
Intervention descriptions: intervention 1: None intervention 2: None intervention 3: None

Protocol document: