Conditions: Refractory Chronic Cough
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 24
Healthy volunteers: no

Brief summary:
This was an 8-week randomized, parallel, double-blind, placebo-controlled study of gefapixant (AF-219) in participants with refractory chronic cough.

Detailed description:

Arms:
arm 1: Two 7.5 mg gefapixant tablets administered by mouth twice daily for 8 weeks arm 2: Four 7.5 mg gefapixant tablets administered by mouth twice daily for 8 weeks arm 3: One 50 mg gefapixant tablet administered by mouth twice daily for 8 weeks arm 4: Matching placebo tablets administered by mouth twice daily for 8 weeks

Interventions: intervention 1: Gefapixant intervention 2: Placebo (for gefapixant)
Intervention descriptions: intervention 1: Gefapixant tablets administered by mouth twice daily for 8 weeks intervention 2: Matching placebo to gefapixant tablets administered by mouth twice daily for 8 weeks

Protocol document: