Conditions: HIV-1 Infection
Keywords: Efavirenz Raltegravir Combination antiretroviral therapy
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 107
Healthy volunteers: no

Brief summary:
A pilot study to compare the efficacy and safety of raltegravir-based versus efavirenz-based combination therapy in treatment-naïve patients with HIV-1 infection.

Detailed description:
A single-center, prospective, randomized, open label, parallel study to compare the efficacy and safety of raltegravir-based versus efavirenz-based plus optimal nucleoside reverse-transcriptase inhibitors(NRTIs) backbone combination therapy in treatment-naïve patients with HIV-1 infection.

Arms:
arm 1: Raltegravir 400mg oral twice daily arm 2: Efavirenz 600mg oral at bedtime

Interventions: intervention 1: Raltegravir intervention 2: Efavirenz
Intervention descriptions: intervention 1: Raltegravir 400mg oral twice daily intervention 2: Efavirenz 600mg oral at bedtime

Protocol document: