Conditions: Gastrointestinal Hemorrhage Clostridium Difficile Colitis
Keywords: Enteral Nutrition Stress Ulcer Prophylaxis Critically Ill Patients Overt and significant GI bleeding Stress gastropathy Clostridium Difficile pseudomembranous colitis Vital AF Small peptide fish oil structured lipids Fructose oligosaccharide
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 124
Healthy volunteers: no

Brief summary:
study is to determine if proton pump inhibitors plus enteral nutrition is superior to enteral nutrition alone as a stress ulcer prophylaxis strategy in critically ill patients in terms of incidence of overt and significant GI bleeding related to stress gastropathy.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Pantoprazole 40 mg IV daily and tube feed. intervention 2: Placebo and tube feed
Intervention descriptions: intervention 1: Patients randomized to the control group "active Comparator" will receive tube feed plus an Pantoprazole 40 mg IV daily. intervention 2: Patients randomized to Placebo group "placebo Comparator" will receive tube feed plus an Placebo.

Protocol document: