Conditions: Evaluate Two Paradigms for Simultaneous Assessment of Hepatic and Intestinal CYP3A
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 6
Healthy volunteers: yes

Brief summary:
To evaluate two paradigms for simultaneous assessment of hepatic and intestinal CYP3A activity.

Detailed description:

Arms:
arm 1: Alfentanil (0.5-1 mg IV bolus) followed 3 hours later or simultaneously by 1-4 mg oral deuterium-labeled (d3) alfentanil on each study visit.

Interventions: intervention 1: Alfentanil
Intervention descriptions: intervention 1: No drug treatment before alfentanil

Protocol document: