Conditions: Head and Neck Neoplasms Carcinoma, Squamous Cell
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 483
Healthy volunteers: no

Brief summary:
This randomised, open-label, phase III study will be performed in patients with R/M head and neck squamous cell carcinoma (HNSCC) who have progressed after platinum-based therapy. The objectives of the trial are to compare the efficacy and safety of afatinib versus methotrexate

Detailed description:

Arms:
arm 1: Once daily arm 2: Weekly

Interventions: intervention 1: Afatinib intervention 2: Methotrexate
Intervention descriptions: intervention 1: Once daily intervention 2: Weekly

Protocol document: