Conditions: Cocaine Abuse Cocaine Dependence
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 15
Healthy volunteers: yes

Brief summary:
This study will determine the initial efficacy, safety and tolerability of n-acetylcysteine as a pharmacotherapy for cocaine dependence. A rigorous, inpatient human laboratory study will be conducted in which the subjective, physiological and reinforcing effects of cocaine are evaluated during maintenance on placebo and n-acetylcysteine.

Detailed description:

Arms:
arm 1: Subjects will be maintained on oral placebo. arm 2: Subjects will be maintained on oral n-acetylcysteine.

Interventions: intervention 1: Cocaine intervention 2: n-Acetylcysteine intervention 3: Placebo
Intervention descriptions: intervention 1: The pharmacodynamic effects of cocaine will be determined during maintenance on placebo and n-acetylcysteine. intervention 2: None intervention 3: None

Protocol document: