Conditions: Metastatic Esophageal Cancer Gastroesophageal Cancer Gastric Cancer
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 27
Healthy volunteers: no

Brief summary:
To estimate and compare the response rates in patients treated with mDCF based on methylation status of CHFR.

Detailed description:
To estimate and compare the response rates in patients treated with mDCF based on methylation status of CHFR. The overall response rates in the un-methylated and methylated patient groups will be reported with a exact 95% binomial confidence interval. A chi-square test will be used for comparison.

Arms:
arm 1: Participants receive Modified Docetaxel 40mg/m2, Leucovorin 400mg/m2 and Fluorouracil 400mg/m2 on day 1, Fluorouracil 1000mg/m2 per day on days 1 and 2 and Cisplatin 40mg/m2 (or Carboplatin) on day 3 in Patients With Metastatic Esophageal, Gastroesophageal And Gastric Cancer.

Interventions: intervention 1: Docetaxel intervention 2: Leucovorin intervention 3: Fluorouracil intervention 4: Cisplatin
Intervention descriptions: intervention 1: Modified Docetaxel 40mg/m2 on Day 1 intervention 2: Leucovorin 400mg/m2 on Day 1 intervention 3: Fluorouracil 400mg/m2 on Day 1 Fluorouracil 1000mg/m2/day on Days 1 and 2 intervention 4: Cisplatin (or Carboplatin) 40mg/m2 on Day 3

Protocol document: