Conditions: Healthy
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 16
Healthy volunteers: yes

Brief summary:
The primary objective of this trial is to investigate the effect of multiple doses of itraconazole on the pharmacokinetics of BI 1026706 given as single dose. The assessment of safety and tolerability of BI 1026706 is an additional objective of this trial. Furthermore, the pharmacokinetics of the metabolite BI 1072668 will be explored.

Detailed description:

Arms:
arm 1: Single dose arm 2: 7 days of itraconazole treatment combined with a single dose of 1026706 on day 4

Interventions: intervention 1: BI 1026706 intervention 2: Itraconazole
Intervention descriptions: intervention 1: Single dose of BI 1026706 on Day 1 intervention 2: 7 days of itraconazole treatment combined with a single dose of BI 1026706 on the fourth day

Protocol document: