Conditions: Renal Impairment
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 16
Healthy volunteers: yes

Brief summary:
This study will evaluate the effect of severe renal impairment on the pharmacokinetics of doravirine.

Detailed description:

Arms:
arm 1: Participants with severe renal impairment receive a single oral dose of 100 mg doravirine arm 2: Healthy participants matched for age and weight receive a single oral dose of 100 mg doravirine

Interventions: intervention 1: Doravirine
Intervention descriptions: intervention 1: Following an overnight fast, a single coated tablet of 100 mg doravirine will be administered orally

Protocol document: