Conditions: Acute Ischaemic Stroke Transient Ischaemic Attack
Keywords: Acute ischaemic stroke. Transient ischaemic attack.
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 13307
Healthy volunteers: no

Brief summary:
The primary objective of the study is to compare the effect of 90-day treatment with ticagrelor (180 mg \[two 90 mg tablets\] loading dose on Day 1 followed by 90 mg twice daily maintenance dose for the remainder of the study) vs acetylsalicylic acid (ASA)-aspirin (300 mg \[three 100 mg tablets\] loading dose on Day 1 followed by 100 mg once daily maintenance dose for the remainder of the study) for the prevention of major vascular events (composite of stroke, myocardial infarction \[MI\], and death) in patients with acute ischaemic stroke or transient ischaemic attack (TIA).

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: ticagrelor intervention 2: Acetylsalicylic acid (ASA)
Intervention descriptions: intervention 1: ticagrelor, 180 mg (two tablets of 90 mg) loading dose on Day 1 followed by 90 mg twice daily. intervention 2: ASA, 300 mg (three tablets of 100 mg) on Day 1, followed by 100 mg once daily.

Protocol document: