Conditions: Respiratory Infection
Keywords: Vitamin D Deficiency Respiratory Infection Nursing Home Residents Geriatrics Immunosenescence Prevention
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 107
Healthy volunteers: no

Brief summary:
This study will test the role of high dose vitamin D supplementation in prevention of acute respiratory infection in older nursing home residents. The investigators hypothesize that residents on high dose vitamin D supplementation will have a lower incidence of acute respiratory infection that those on standard dose vitamin D supplementation.

Detailed description:
This study is a double-blinded, parallel group, randomized controlled phase II trial of oral high vs. standard dose vitamin D3 supplementation administered monthly for 12 months.

Arms:
arm 1: 100,000 IU Vitamin D3 (cholecalciferol) monthly for 12 months. When added to usual care (0-1000 IU Vitamin D per day), averages 3,300-4,300 IU per day. arm 2: 12,000 IU Vitamin D3 (cholecalciferol) or placebo monthly for 12 months. When added to usual care (0-1000 IU Vitamin D per day), averages 400-1,000 IU per day.

Interventions: intervention 1: High Dose Vitamin D intervention 2: Standard Dose Vitamin D intervention 3: Placebo intervention 4: Usual Care
Intervention descriptions: intervention 1: Vitamin D3 100,000 IU monthly intervention 2: Vitamin D 12,000 IU monthly intervention 3: Placebo monthly intervention 4: Usual care of 0-1000 IU vitamin D daily. This is present in both study arms.

Protocol document: