Conditions: Alcohol Drinking
Keywords: alcohol nicotine smoking cessation smoking cessation medications
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 22
Healthy volunteers: no

Brief summary:
This study examines the effect of combined nicotine replacement therapy (transdermal patch + nasal spray vs. transdermal patch + placebo nasal spray) on reactivity to alcohol and self-administration behavior.

Detailed description:

Arms:
arm 1: Within subject design. All volunteers complete two laboratory sessions. In one session they receive nicotine patch + nicotine nasal spray. arm 2: Within subject design. All volunteers complete two laboratory sessions. In one session they receive nicotine patch + placebo nicotine nasal spray.

Interventions: intervention 1: 21mg transdermal nicotine patch (Nicoderm CQ) intervention 2: 1mg nicotine nasal spray intervention 3: placebo nasal spray
Intervention descriptions: intervention 1: 21mg transdermal nicotine patch intervention 2: two 0.5mg/sprays, one to each nostril (dose = 1mg) The nicotine nasal spray is formulated by the Investigational Drug Service at Yale-New Haven Hospital. It is similar in concentration to Nicotrol. intervention 3: saline combined with capsaicin to mimic the brief nasal irritation from active nicotine spray The placebo nasal spray is formulated by the Investigational Drug Service at Yale-New Haven Hospital.

Protocol document: