Conditions: Atrial Fibrillation
Keywords: atrial fibrillation catheter ablation left atrium mechanical function contractility
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 64
Healthy volunteers: no

Brief summary:
The objective of the study was to estimate the efficacy of telmisartan and amlodipine combination on the restoration of left atrial mechanical function after atrial fibrillation catheter ablation.

Detailed description:
64 candidates to atrial fibrillation ablation were included in the study. Patients were randomly assigned to telmisartan/amlodipine combination in dose 80/5 mg (group I, n=34) or placebo (group II, n=30) taking daily for up to one week. Echocardiography was performed before the procedure, immediately after it, and after a week of therapy. The six-minute walk test and SF-36 questionnaire results were evaluated a day before the procedure and after a week of the therapy. The left ventricular end-diastolic pressure was invasively measured after transseptal puncture and before left atrial sheath removal.

Arms:
arm 1: Telmisartan 80 mg and amlodipine 5 mg tablet by mouth every 24 hours for 7 days arm 2: Placebo (for telmisartan 80 mg and amlodipine 5 mg) tablet by mouth every 24 hours for 7 days

Interventions: intervention 1: Telmisartan 80 mg and amlodipine 5 mg intervention 2: Placebo (for telmisartan and amlodipine)
Intervention descriptions: intervention 1: None intervention 2: Sugar pill manufactured to mimic telmisartan 80 mg and amlodipine 5 mg tablet

Protocol document: