Conditions: Atrial Fibrillation
Keywords: atrial fibrillation catheter ablation colchicine c reactive protein CRP
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 26
Healthy volunteers: no

Brief summary:
Colchicine will lower C-reactive protein (CRP) in chronic atrial fibrillation and reduce the rise in CRP which occurs following atrial fibrillation ablation

Detailed description:
Three groups of patients will be randomized to colchicine 0.6 mg PO bis in die (BID) or matching placebo:

1. Paroxysmal atrial fibrillation, pre-ablation
2. Persistent atrial fibrillation, pre-ablation
3. Chronic persistent atrial fibrillation

Arms:
arm 1: Colchicine 0.6 mg PO BID. Subjects not undergoing ablation. arm 2: Matching placebo. Subjects not undergoing ablation. arm 3: Colchicine 0.6 mg PO BID. Subjects undergoing ablation. arm 4: Matching placebo. Subjects undergoing ablation. arm 5: Colchicine 0.6 mg PO BID. Subjects undergoing ablation. arm 6: Matching placebo. Subjects undergoing ablation.

Interventions: intervention 1: Colchicine, 0.6 mg PO BID intervention 2: Matching placebo
Intervention descriptions: intervention 1: Colchicine tablets will be over-encapsulated by the research pharmacy to be indistinguishable from placebo intervention 2: Matching placebo tablets will be encapsulated by the research pharmacy to be indistinguishable from active drug

Protocol document: