Conditions: Smoking
Keywords: smoking lapse behavior smoking cessation doxazosin medication effect on smoking lapse behavior medication effect on smoking cessation stress
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 35
Healthy volunteers: yes

Brief summary:
The purpose of this study is to examine whether doxazosin will attenuate the ability of stress to precipitate smoking lapse behavior in treatment seeking daily smokers. Participants will participate in a smoking cessation attempt after the laboratory sessions.

Detailed description:

Arms:
arm 1: doxazosin 4mg/day arm 2: placebo control arm 3: doxazosin 8mg/day

Interventions: intervention 1: Doxazosin 4mg/day intervention 2: Placebo intervention 3: Doxazosin 8mg/day
Intervention descriptions: intervention 1: 4 mg/day with 3-week lead-in medication period. Maintained at steady state for duration of the study. 5-day taper at the end of the study. intervention 2: Placebo intervention 3: 8 mg/day with 3-week lead-in medication period. Maintained at steady state for duration of the study. 5-day taper at the end of the study.

Protocol document: