Conditions: Non-infectious Anterior Uveitis
Keywords: uveitis acute uveitis anterior uveitis NS2 Aldeyra prednisolone acetate
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 45
Healthy volunteers: no

Brief summary:
This is a randomized, multi-center, investigator masked, comparator controlled study. The purpose of this study is to determine the efficacy and safety of NS2 in patients with non-infectious acute anterior uveitis. Subjects will be randomized 1:1:1 to receive multiple doses of NS2 0.5%, NS2 0.5% and Pred Forte® 1%, or Pred Forte® 1%.

Free aldehydes are thought to be related to inflammatory diseases such as uveitis. NS2, a small molecule aldehyde trap, may decrease inflammation by lowering aldehyde levels.

Detailed description:

Arms:
arm 1: NS2 ophthalmic drops (0.5%) in the affected eye arm 2: NS2 ophthalmic drops (0.5%) and Prednisolone acetate ophthalmic suspension (1%) in the affected eye arm 3: Prednisolone acetate ophthalmic suspension (1%) in the affected eye

Interventions: intervention 1: NS2 intervention 2: Prednisolone acetate ophthalmic suspension (1%)
Intervention descriptions: intervention 1: NS2 ophthalmic drops (0.5%) intervention 2: None

Protocol document: