Conditions: Pulmonary Embolism
Keywords: Pulmonary embolism clot
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 78
Healthy volunteers: no

Brief summary:
This is a randomized study to treat subjects diagnosed with pulmonary embolism with inhaled nitric oxide or placebo (oxygen).

Detailed description:
This is a randomized, double blind study to treat subjects diagnosed with pulmonary embolism with inhaled nitrix oxide. In this clinical trial investigators will randomized patients to receive inhaled nitric oxide or sham (nitrogen + oxygen) for 24 hours. Patients must have a submassive pulmonary embolism (PE) and evidence of right ventricular (RV) heart dysfunction. Investigators hypothesize that the administration of inhaled NO + oxygen to patients with severe submassive PE will improve RV function, reduce RV strain and necrosis and improve dyspnea (difficulty breathing) more than sham oxygen treatment.

Arms:
arm 1: Inhaled nitric oxide arm 2: Oxygen

Interventions: intervention 1: Inhaled Nitric Oxide intervention 2: Sham
Intervention descriptions: intervention 1: Nitric Oxide + oxygen intervention 2: Nitrogen + Oxygen

Protocol document: