Conditions: Headache
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 122
Healthy volunteers: yes

Brief summary:
This trial is a prospective, randomized, feasibility trial with the primary aim of comparing how well oral rapidly dissolving olanzapine controls primary headache pain when compared to the current treatment strategies used in emergency departments which often require intravenous or intramuscular medications.

Detailed description:
Primary Question:

Does oral rapidly dissolving olanzapine provide efficacious analgesia in patients with acute headache of non-organic origin (primary headache) who come to the ED for abortive therapy when compared to current standard of care?

Secondary Aim:

Additionally, the study will aim to see if oral rapidly dissolving olanzapine decreases 1) duration of ED length of stay and 2) need for IV access when compared to the current standard of care.

This is a prospective, randomized, convenience sample, feasibility trial to test for non-inferiority of oral rapidly dissolving olanzapine versus current emergency department standard of care in providing symptomatic relief to patients presenting with primary headache.

Arms:
arm 1: IV Morphine or any medication per attending decision arm 2: oral rapidly dissolving olanzapine (Zydis) 5 mg for analgesia in acute primary headaches.

Interventions: intervention 1: Standard of Care as per attending physician intervention 2: 5mg rapidly dissolving olanzapine
Intervention descriptions: intervention 1: Patients are randomized to standard of care medication (as determined by attending physician) intervention 2: 5mg rapidly dissolving olanzapine

Protocol document:
Prot_SAP_000.pdf: