Conditions: Postoperative Nausea and Vomiting
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 150
Healthy volunteers: no

Brief summary:
Previous reports demonstrated that dexmedetomidine could reduce the incidence of postoperative nausea and vomiting (PONV). Dexamethason also had been commonly used for ajuvant drugs for preventing and reducing PONV. So investigator want to study about the effect of dexmedetomidine only or combined with dexamethasone for preventing PONV.

Detailed description:
Previous reports demonstrated that dexmedetomidine, a alpha 2 selective agonist could reduce the incidence of postoperative nausea and vomiting (PONV). Dexamethason also had been commonly used for ajuvant drugs for preventing and reducing PONV. So investigator want to study about the effect of dexmedetomidine only or combined with dexamethasone for preventing PONV.

Arms:
arm 1: administration of 0.9% normal saline 10ml arm 2: administration of 0.5ug/kg of dexmedetomidine (5ml) arm 3: administration of 0.5 ug/kg of dexmedetomidine and dexamethasone 5mg (total 5ml)

Interventions: intervention 1: Dexmedetomidine intervention 2: Dexmedetomidine and dexamethasone intervention 3: Control
Intervention descriptions: intervention 1: administration of dexmedetomidine only intervention 2: administration of dexmedetomidine and dexamethasone intervention 3: administration of normal saline

Protocol document: