Conditions: Healthy
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 60
Healthy volunteers: yes

Brief summary:
The purpose of this study is to learn about the effect of lanabecestat on how the body absorbs and processes dabigatran etexilate and how dabigatran etexilate affects lanabecestat when they are taken together. This study will last about 28 days and participants will be asked to take an lanabecestat tablet daily for 19 days and a dabigatran etexilate tablet on 3 occasions. Screening is required within 30 days prior to the start of the study.

Detailed description:

Arms:
arm 1: Single dose of dabigatran etexilate administered orally. arm 2: Single dose of lanabecestat administered orally once daily on Days 3 to 21. Single doses of dabigatran etexilate administered orally on Days 16 and 20 during the lanabecestat dosing.

Interventions: intervention 1: Lanabecestat intervention 2: Dabigatran etexilate
Intervention descriptions: intervention 1: Administered orally intervention 2: Administered orally

Protocol document: