Conditions: Heart Failure
Keywords: loop diuretics heart failure natriuresis urinary analysis
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 50
Healthy volunteers: no

Brief summary:
The primary objective of this study is to assess whether the urinary sodium/creatinine or chloride/creatinine ratio might predict successful downtitration of loop diuretics in patients with stable heart failure without clinical signs of volume overload. In addition, this study will provide information on loop diuretic efficiency and urinary electrolyte composition after intake of diuretics in stable outpatients with heart failure.

Detailed description:

Arms:
arm 1: Scheduled downtitration of maintenance loop diuretic dose while monitoring weight

Interventions: intervention 1: Weight monitoring intervention 2: Loop diuretic downtitration
Intervention descriptions: intervention 1: The body weight of patients is measured each morning in identical conditions on the same balance during 7 days intervention 2: The patient's total daily maintenance dose of loop diuretics is downtitrated during 7 consecutive days.

In case of a total daily maintenance dose ≤40 mg furosemide OR ≤1 mg bumetanide OR ≤20 mg torsemide, the loop diuretic is completely stopped.

In case of a total daily maintenance dose \>40 mg furosemide OR \>1 mg bumetanide OR \>20 mg torsemide, the loop diuretic dose is halved.

Protocol document: