Conditions: Facial Aesthetic Treatment
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 61
Healthy volunteers: yes

Brief summary:
The efficacy and safety, as well as subject satisfaction will be evaluated after single treatment with Azzalure alone or Restylane/Emervel filler alone followed by repeated combined treatment with Azzalure, Restylane/Emervel filler and Restylane Skinbooster. Subjects will be followed for up to 18 months after initial treatment.

Detailed description:

Arms:
arm 1: Azzalure alone as single treatment at initial treatment followed by two combined treatments with Azzalure, HA filler and Skinboosters at Month 6 and Month 12. arm 2: HA filler alone as single treatment at initial treatment followed by two combined treatments with Azzalure, HA filler and Skinboosters at Month 6 and Month 12.

Interventions: intervention 1: Azzalure intervention 2: Restylane/Emervel filler intervention 3: Restylane Skinbooster
Intervention descriptions: intervention 1: Glabellar lines intervention 2: Facial tissue augmentation intervention 3: Facial skin rejuvenation

Protocol document: