Conditions: Ulcerative Colitis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 357
Healthy volunteers: no

Brief summary:
To determine the dose or doses of PF-00547659 that will be the most effective to improve or halt the disease symptoms in patients with moderate to severe ulcerative colitis.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None arm 4: None arm 5: None

Interventions: intervention 1: Placebo intervention 2: PF-00547659 SC Injection intervention 3: PF-00547659 SC Injection intervention 4: PF-00547659 SC Injection intervention 5: PF-00547659 SC Injection
Intervention descriptions: intervention 1: Placebo delivered subcutaneous injection, 3 doses separated by 4 weeks intervention 2: Drug Dose Level 1 delivered subcutaneous injection, 3 doses separated by 4 weeks intervention 3: Drug Dose Level 2 delivered subcutaneous injection, 3 doses separated by 4 weeks intervention 4: Drug Dose Level 3 delivered subcutaneous injection, 3 doses separated by 4 weeks intervention 5: Drug Dose Level 4 delivered subcutaneous injection, 3 doses separated by 4 weeks

Protocol document: