Conditions: Healthy
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 23
Healthy volunteers: yes

Brief summary:
The aims of this study are to evaluate:

* The safety and tolerability of a single dose of treprostinil given subcutaneously (as an injection just under the skin)
* The pharmacokinetic profile (how the body absorbs, breaks down, and gets rid of) of a single subcutaneous dose of a new LY900014 formulation in healthy Japanese participants.

The study has two parts. Participants may only enroll in one part.

Detailed description:

Arms:
arm 1: Treprostinil administered as a single subcutaneous (SC) bolus injection. arm 2: Placebo administered as a single SC bolus injection. arm 3: LY900014 (test) administered as a single SC bolus injection. arm 4: Insulin lispro (reference) administered as a single SC bolus injection.

Interventions: intervention 1: Treprostinil intervention 2: Placebo intervention 3: LY900014 intervention 4: Insulin Lispro
Intervention descriptions: intervention 1: Administered SC. intervention 2: Administered SC. intervention 3: Administered SC. intervention 4: Administered SC.

Protocol document: