Conditions: Ulcerative Colitis
Keywords: Ulcerative Colitis, Japanese, subcutaneously
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 44
Healthy volunteers: no

Brief summary:
This is a multi-centre, randomised, double-blind, placebo controlled, parallel group, Phase II study to evaluate efficacy and safety of 3 doses of MEDI7183, in Japanese subjects with moderate to severe UC

Detailed description:

Arms:
arm 1: Double blinded arm 2: Double blinded arm 3: Double blinded arm 4: Double blinded

Interventions: intervention 1: MEDI7183 low dose intervention 2: MEDI7183 medium dose intervention 3: MEDI7183 high dose intervention 4: Matching Placebo
Intervention descriptions: intervention 1: MEDI7183 will be administered by SC on Day 1, Week 2, 4, and 8 intervention 2: MEDI7183 will be administered by SC on Day 1, Week 2, 4, and 8 intervention 3: MEDI7183 will be administered by SC on Day 1, and placebo for MEDI7183 at Week 2, 4, and 8 intervention 4: Placebo will be administered by SC on Day 1, Week 2,4, and 8

Protocol document: