Conditions: Alzheimer's Disease
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 36
Healthy volunteers: no

Brief summary:
This study aims to determine whether the Cogstate testing battery can detect improvements in cognitive function in participants with mild AD. The primary hypothesis is that for one of the Cogstate battery tests, One Card Learning (OCL), the standard deviation associated with the change from baseline in OCL measurements after 12 weeks of donepezil and placebo treatments is =\<0.1

Detailed description:

Arms:
arm 1: Placebo for donepezil hydrochloride capsule administered orally once a day for 16 weeks. arm 2: During the first 4 weeks, participants received placebo for donepezil. Over the following 2 weeks, participants were treated with donepezil at 5 mg per day. Then, over the remaining 10 weeks were titrated to up to 10 mg per day donepezil based on tolerability.

Interventions: intervention 1: Placebo intervention 2: Donepezil intervention 3: Donepezil
Intervention descriptions: intervention 1: Placebo for donepezil hydrochloride capsule intervention 2: 5 mg donepezil hydrochloride capsule. intervention 3: 10 mg donepezil hydrochloride capsule.

Protocol document: