Conditions: Metabolic Syndrome
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 15
Healthy volunteers: no

Brief summary:
Our research proposal will determine if PDE-5 inhibition exerts a favorable effect on insulin signaling pathways in skeletal muscle of subjects with impaired fasting glucose and/or impaired glucose tolerance.

Detailed description:
Participants enrolled in the study titled " Renin-angiotensin and fibrinolysis interaction in humans: effect of long-term PDE5 inhibition on glucose Homeostasis, (Specific aim 2)" will be offered the opportunity to participate in this sub-study.

We will obtain skeletal muscle biopsies from 16 subjects who are enrolled in specific aim 2. Eight subjects will be in the sildenafil group and 8 subjects will be in the placebo group.

Arms:
arm 1: In the parent study, subjects are randomized to sildenafil 25 mg tid. arm 2: In the parent study, subjects are randomized to matching placebo

Interventions: intervention 1: Sildenafil citrate intervention 2: Placebo Oral Capsule
Intervention descriptions: intervention 1: Sildenafil citrate 25 mg, 1 capsule three times a day for 3 months intervention 2: placebo capsules, 1 capsule po three times a day for 3 months

Protocol document: