Conditions: HIV Infections
Keywords: HIV Vitamin D Deficiency
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 190
Healthy volunteers: yes

Brief summary:
The purpose of this study is to determine the correct dose of Vitamin D to give to prevent HIV related complications.

Detailed description:
The purpose of the this study was to compare control dose of vitamin D (low dose of 600 IU/d) to supplementation dose (medium dose of 2000 IU/d or higher doses of vitamin D of 4000 IU/d) on HIV-related comorbidities including immune activation, inflammation, cardiovascular diseases, and metabolic complications in HIV-infected youth.

Arms:
arm 1: All will be HIV+ and receiving randomized dose of vitamin D control dose (low dose) or supplementation dose (vitamin D medium dose or vitamin D high dose) arm 2: HIV negative controls will be receiving randomized Vitamin D doses: control vitamin D dose (low dose) or vitamin D supplementation dose (vitamin D medium dose or vitamin D high dose)

Interventions: intervention 1: Vitamin D control dose intervention 2: Vitamin D supplementation-
Intervention descriptions: intervention 1: 18,000 IU per month intervention 2: 60,000 IU per month(medium dose) or 120,000 IU/month(high dose)

Protocol document: