Conditions: Psychotic Disorders Schizophrenia Schizoaffective Disorder Bipolar Disorder
Keywords: Psychotic Schizophrenia Schizoaffective Bipolar
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 8
Healthy volunteers: no

Brief summary:
This study evaluates the feasibility of administering meclofenamic acid or pentosan polysulfate sodium as an adjunctive treatment to patients diagnosed with a psychotic disorder. Half of participants will receive meclofenamic acid, while the other half will receive polysulfate sodium.

Detailed description:
Chronic, low-grade brain inflammation is involved in the development of schizophrenia and other psychotic disorders. Medications with anti-inflammatory properties, like meclofenamic acid and pentosan polysulfate may help to reduce brain inflammation and serve as a treatment of psychotic disorders.

Arms:
arm 1: 150mg meclofenamic acid daily for 8 weeks arm 2: 300mg of pentosan polysulfate sodium daily for 8 weeks

Interventions: intervention 1: Meclofenamic acid intervention 2: Pentosan polysulfate sodium
Intervention descriptions: intervention 1: None intervention 2: None

Protocol document: