Conditions: Marijuana Dependence
Keywords: marijuana substance abuse drug abuse marijuana dependence drug addiction
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 16
Healthy volunteers: no

Brief summary:
The purpose of this study is to examine the impact of a medication called oxytocin on marijuana use and therapy response in people who frequently use marijuana.

Detailed description:
Oxytocin has been shown to promote trust, social bonding, and calmness; however, its potential additive effects with a therapy intervention have not been explored in marijuana-dependent individuals. In the proposed study, the impact of intranasal oxytocin on therapy effectiveness and marijuana use outcomes following a brief therapy intervention will be investigated. It is hypothesized that oxytocin administration (vs. placebo) will improve treatment satisfaction and decrease marijuana use.

Arms:
arm 1: intranasal administration arm 2: intranasal administration

Interventions: intervention 1: Oxytocin intervention 2: Saline
Intervention descriptions: intervention 1: Subjects will be administered 40 IUs of oxytocin nasal spray or matching placebo prior to two individual sessions of MET. intervention 2: Subjects will be administered 40 IUs of oxytocin nasal spray or matching placebo prior to two individual sessions of MET.

Protocol document: