Conditions: Blood Pressure, High
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 166
Healthy volunteers: no

Brief summary:
This trial is designed to:

1. Assess the response to montherapy with : a thiazide diuretic (HCTZ), a calcium-channel blocker (CCB, amlodipine) and an angiotensin-receptor blocker (telmisartan), among hypertensive subjects who live at sea level, at medium altitude above sea level and at high altitude above sea level.
2. To test whether diferentes exist in the response to therapy among subjects who live at different altitude above sea level
3. To assess the hemodynamic characteristics of hypertension in populations that live at sea level, at medium altitude above sea level, and at high altitude above sea level.

Detailed description:

Arms:
arm 1: Therapy with hydrochlorothiazide (25 mg daily) taken once daily between 6 and 8 AM arm 2: Therapy with amlodipine (10 mg daily) taken once daily between 6 and 8 AM arm 3: Therapy with Telmisartan (80 mg daily) taken once daily between 6 and 8 AM

Interventions: intervention 1: Hydrochlorothiazide intervention 2: Amlodipine intervention 3: Telmisartan
Intervention descriptions: intervention 1: Arm: Active Comparator: Diuretic Therapy with hydrochlorothiazide (25 mg daily) taken once daily between 6 and 8 AM Arm: Active Comparator: Calcium-channel blocker Therapy with amlodipine (10 mg daily) taken once daily between 6 and 8 AM Arm: Active Comparator: Angiotensin Receptor Blocker Therapy with Telmisartan (80 mg daily) taken once daily between 6 and 8 AM intervention 2: Therapy with amlodipine (10 mg daily) taken once daily between 6 and 8 AM intervention 3: Therapy with Telmisartan (80 mg daily) taken once daily between 6 and 8 AM

Protocol document: