Conditions: Impaired Glucose Tolerance
Keywords: BMI greater than 25 Elevated fasting blood sugar (100-125mg/dL)
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 78
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine the effect of chronic PDE5 inhibitor therapy on glucose metabolism in persons with prediabetes.

Detailed description:

Arms:
arm 1: sildenafil 25 mg p.o. tid arm 2: matching placebo p.o. tid arm 3: sildenafil 25 mg p.o. tid arm 4: matching placebo p.o. tid

Interventions: intervention 1: Sildenafil intervention 2: Placebo intervention 3: Hyperglycemic clamp intervention 4: Euglycemic clamp
Intervention descriptions: intervention 1: Sildenafil 25 mg by mouth three times a day for three months intervention 2: Matching placebo three times a day for three months intervention 3: Subjects with prediabetes will have a baseline hyperglycemic clamp (Aim 1) and then receive sildenafil or placebo for 3 months. Another hyperglycemic clamp will be performed followed by another 3 months off drug and an oral glucose tolerance test. intervention 4: Subjects with prediabetes will have a baseline euglycemic clamp (Aim 2) and then receive sildenafil or placebo for 3 months. Another euglycemic clamp will be performed followed by another 3 months off drug and an oral glucose tolerance test.

Protocol document: