Conditions: Colorectal Disorders
Keywords: colorectal surgery volume status
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 123
Healthy volunteers: no

Brief summary:
The purpose of this study is to find out if giving a medicine called furosemide, which is a diuretic or water pill, after colon surgery will safely shorten the patient's length of hospital stay.

Detailed description:
This study will assess if administration of a loop diuretic, specifically furosemide, to achieve euvolemia can safely reduce length of stay following colorectal surgery.

Arms:
arm 1: Furosemide 10 mg IV on post-operative day #1 and/or 2, plus ERAS, as described in other arm. arm 2: ERAS included administration of celecoxib and gabapentin in the pre-operative setting, single-injection intrathecal analgesic administration immediately prior to induction of general anesthesia, post-operative administration of scheduled acetaminophen and nonsteroidal anti-inflammatory drug (NSAID) or tramadol, and discontinuation of IV fluids by 0800 on postoperative day (POD) 1. Intraoperative fluid administration was dependent on the individual anesthesia provider with no unified commitment to either zero balance or goal-directed fluid therapy. Fluid status was determined based on patient weight. Patients were weighed preoperatively and daily post-operatively using either a bed scale or a unit-based scale.

Interventions: intervention 1: Furosemide intervention 2: Celecoxib intervention 3: Gabapentin
Intervention descriptions: intervention 1: None intervention 2: Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain or inflammation. intervention 3: Gabapentin is a oral drug used to treat seizures, postherpetic neuralgia, and restless legs syndrome.

Protocol document: