Conditions: Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Myelodysplasia Chronic Myeloid Leukemia
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 9
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine if haplotype-mismatched HSCT is associated with an improvement in treatment-related mortality (TRM) rate at 6 months.

Detailed description:

Arms:
arm 1: Total body Irradiation; Thiotepa; Fludarabine; Rabbit ATG; arm 2: Palifermin; Total Body Irradiation; Thiotepa; Fludarabine; Rabbit ATG

Interventions: intervention 1: Total Body Irradiation intervention 2: Thiotepa intervention 3: Fludarabine intervention 4: Rabbit ATG intervention 5: Palifermin
Intervention descriptions: intervention 1: 8 Gy on Day -9 intervention 2: 5 mg/kg/d on Day -8 to -7 intervention 3: 40 mg/m2/d on Day -6 to -3 intervention 4: 2.5 mg/kg/d on Day -5 to -2 intervention 5: 60 ug/kg (actual body weight) on Day -9 to -7 and Day 0 to +2

Protocol document: