Conditions: Human Immunodeficiency Virus (HIV) Infection
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 14
Healthy volunteers: yes

Brief summary:
This study will evaluate the effects of multiple doses of doravirine (MK-1439) on the pharmacokinetics of methadone in participants requiring methadone maintenance therapy. The primary hypothesis is that area under the plasma concentration-time curve to 24 hours postdose (AUC0-24) of (R)-methadone is similar when a maintenance regimen of methadone is administered with or without multiple daily doses of doravirine.

Detailed description:

Arms:
arm 1: Participants maintained on a stable methadone regimen (20 to 200 mg once daily) for ≥14 days prior to Day 1 will continue to receive methadone maintenance once per day on Days 1 to 7. From Day 2 to 6, participants will also receive doravirine 100 mg once daily.

Interventions: intervention 1: Methadone intervention 2: Doravirine
Intervention descriptions: intervention 1: Methadone 20 to 200 mg (10 mg/mL if oral solution concentrate) oral tablet once per day. intervention 2: Doravirine 100 mg oral tablet once per day.

Protocol document: