Conditions: Dentin Sensitivity
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 240
Healthy volunteers: yes

Brief summary:
This study will investigate the longitudinal efficacy of two experimental oral rinses, one containing 1.5% weight/weight (w/w) dipotassium oxalate monohydride (KOX) /0 Parts per Million (ppm fluoride) and the other 2.0% w/w KOX /45ppm fluoride, for the relief of dentinal hypersensitivity (DH), compared to a placebo oral rinse, when used as an adjunct to twice daily brushing with a standard fluoride toothpaste.

Detailed description:

Arms:
arm 1: Brushing with fluoride toothpaste for 1 minute followed by rinsing with 10 ml of Experimental Oral Rinse 1 for 1 minute. This regimen will be performed twice daily for 8 weeks. arm 2: Brushing with fluoride toothpaste for 1 minute followed by rinsing with 10 ml of Experimental Oral Rinse 2 for 1 minute. This regimen will be performed twice daily for 8 weeks. arm 3: Brushing with fluoride toothpaste for 1 minute followed by rinsing with 10 ml of Placebo Oral Rinse 2 for 1 minute. This regimen will be performed twice daily for 8 weeks.

Interventions: intervention 1: Experimental Oral Rinse 1 intervention 2: Experimental Oral Rinse 2 intervention 3: Placebo Oral Rinse intervention 4: Fluoride toothpaste
Intervention descriptions: intervention 1: Oral rinse containing 1.5% w/w KOX, 0ppm F, pH 4.5 intervention 2: Oral rinse containing 2.0% w/w KOX, 45ppm F, pH 4.5 intervention 3: Oral rinse containing 0% w/w KOX 0ppm F, pH 4.5 intervention 4: Oral rinse containing 1000ppm fluoride as sodium monofluorophosphate

Protocol document: