Conditions: Breast Cancer
Keywords: hormone-receptor positive advanced breast cancer
Allocation: RANDOMIZED | Intervention model: 
Enrollment: 177
Healthy volunteers: no

Brief summary:
The study is aimed to confirm that letrozole + PD 0332991 is safe and tolerable and to assess the effect of the combination on advanced breast cancer

Detailed description:

Arms:
arm 1: letrozole + PD 0332991 arm 2: letrozole

Interventions: intervention 1: PD 0332991 intervention 2: letrozole intervention 3: letrozole
Intervention descriptions: intervention 1: 125 mg/d capsules orally for 3 out of 4 weeks in repeated cycles intervention 2: 2.5 mg/d tablets orally on a continuous regimen intervention 3: 2.5 mg/d tablets orally on a continuous regimen

Protocol document: