Conditions: Amyloid-beta
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 36
Healthy volunteers: yes

Brief summary:
The purpose of this study is to change the concentration of amyloid-beta in human cerebrospinal fluid (CSF) through modulation of the sleep-wake cycle.

Detailed description:
The purpose of this research study is to investigate whether or not increasing or decreasing duration of sleep over one night will change the concentration of amyloid-beta in cerebral spinal fluid (CSF).

Arms:
arm 1: 7.5 grams of sodium oxybate arm 2: Sleep deprivation for up to 36 hours with no naps or other sleep periods arm 3: Participant will sleep as normal under the same controlled conditions in a clinical research unit

Interventions: intervention 1: Sodium Oxybate intervention 2: Sleep deprivation
Intervention descriptions: intervention 1: Sodium oxybate h.s. intervention 2: 36hr sleep deprivation

Protocol document: