Conditions: Imaging of the Brain and Antipsychotics Neuronal Network Changes
Keywords: Imaging Risperidone Placebo antipsychotic
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 11
Healthy volunteers: yes

Brief summary:
To detect the effect of second-generation antipsychotic drug on the neural activity.

Detailed description:
To detect functional correlation changes in the brain with anti-psychotic drug administration as compared to placebo, and b.) to measure if these changes correlate with the plasma level of anti-psychotic, and c.) to evaluate if these changes correlate with drug induced symptoms and changes in cognitive function.

Arms:
arm 1: This group will receive 2 mg (\>200lbs), 1.5mg (150-200lbs.) or 1 mg (\< 150lbs. of risperidone oral solution on the first day and a placebo on the second day. arm 2: This group will receive a placebo on the first day and 2mg (\> 200lbs.), 1.5mg (150-200lbs), or 1 mg (\<150lbs.) of risperidone oral solution on the second day

Interventions: intervention 1: Risperidone intervention 2: Placebo
Intervention descriptions: intervention 1: We gave oral liquid of risperidone one time 1-2 mg depending on subject's weight. intervention 2: We gave oral liquid without active risperidone (pt and provider were both double blinded)

Protocol document: