Conditions: Herpes Labialis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 54
Healthy volunteers: no

Brief summary:
Subjects with a history of recurrent herpes labialis will be sensitized with either 2% SADBE or placebo. Following this, subjects sensitized with 2% SADBE will received.2% sqauric acid or.5% squaric acid on their cold sore within 72 hours of a recurrence. Subjects sensitized with placebo solution will receive placebo solution on their cold sore within 72 hours of a recurrence. Subjects will be followed for up to 6 mos after application of study medication.

Detailed description:

Arms:
arm 1: 2% Squaric Acid solution will be applied for sensitization to the inner arm. arm 2: Patients in placebo group will be given dimethyl sulfoxide.

Interventions: intervention 1: Squaric Acid solution intervention 2: Placebo solution
Intervention descriptions: intervention 1: None intervention 2: None

Protocol document: