Conditions: Chronic Kidney Disease Metabolic Acidosis
Keywords: Alkali Sodium bicarbonate Kidney disease Acidosis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 149
Healthy volunteers: no

Brief summary:
Kidney disease is a common medical condition. Individuals with kidney disease develop a build-up of acid in their blood. This acid can affect their muscles, bones, glucose metabolism and kidneys. The investigators will test alkali treatment, to treat acid build-up, in a randomized placebo-controlled clinical trial to evaluate effects on muscles, bones, glucose metabolism and kidney.

Detailed description:

Arms:
arm 1: 0.4 mEq/kg/day ideal body weight to be taken once a day arm 2: placebo dosage/frequency equivalent to sodium bicarbonate

Interventions: intervention 1: Sodium bicarbonate intervention 2: Placebo
Intervention descriptions: intervention 1: 0.4 mEq/kg/day ideal body weight to be taken once a day intervention 2: To be taken on the same schedule as the active arm

Protocol document: