Conditions: Cardiac Index
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 131
Healthy volunteers: no

Brief summary:
The purpose of this study is to find out the effect of low abdominal pressure vs. standard abdominal pressure on the cardiac and respiratory function of the patients undergoing laparoscopic colon surgery in Trendelenberg position. It was also designed to evaluate the effect of the degree of neuromuscular blockade on the surgical condition of the patients undergoing laparoscopic colon surgery in Trendelenberg position.

Detailed description:

Arms:
arm 1: Patients who receive laparoscopic colon surgery under Trendelenberg position with conventional neuromuscular blockade and standard abdominal pressure. arm 2: Patients who receive laparoscopic colon surgery under Trendelenberg position with deep neuromuscular blockade and standard abdominal pressure. arm 3: Patients who receive laparoscopic colon surgery under Trendelenberg position with deep neuromuscular blockade and low abdominal pressure.

Interventions: intervention 1: Standard abdominal pressure intervention 2: Low abdominal pressure intervention 3: Conventional neuromuscular blockade intervention 4: Deep neuromuscular blockade
Intervention descriptions: intervention 1: Abdominal pressure maintained 12mmHg throughout laparoscopic colon surgery intervention 2: Abdominal pressure maintained 8mmHg throughout laparoscopic colon surgery intervention 3: Anesthesia induction with rocuronium 0.4mg/kg and maintenance with rocuronium 0.15mg/kg to maintain TOF 1-2 twitch intervention 4: Anesthesia induction with rocuronium 0.8mg/kg → maintenance with rocuronium 0.3mg/kg to maintain PTC 1-2 twitch

Protocol document: