Conditions: Acute Pain, Postoperative
Keywords: Elective total knee arthroplasty
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 1
Healthy volunteers: no

Brief summary:
The purpose of this study is to compare intravenous (IV) and oral acetaminophen for the treatment of acute moderate to severe pain in combination with standard patient-controlled analgesia (PCA) in adult subjects following total knee replacement.

Detailed description:

Arms:
arm 1: IV acetaminophen 1000 mg every 6 hours over 18 hours arm 2: Oral acetaminophen two 500 mg tablets every 6 hours over 18 hours

Interventions: intervention 1: IV acetaminophen intervention 2: Oral acetaminophen intervention 3: Morphine
Intervention descriptions: intervention 1: None intervention 2: None intervention 3: Patient controlled analgesia

Protocol document: