Conditions: Pseudohypoparathyroidism Type 1a Albright Hereditary Osteodystrophy
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 6
Healthy volunteers: no

Brief summary:
This study will test an investigational drug, theophylline, in children with pseudohypoparathyroidism type 1a (PHP1a). This study involves a 3 day visit to the Vanderbilt Clinical Research Center.

Detailed description:
Study measures will be done at baseline and during a 24h infusion of IV theophylline. Theophylline levels will be drawn to ensure therapeutic dosing and to monitor for toxicity. Measures include laboratory values, response to PTH infusion and resting energy expenditure.

Arms:
arm 1: Patients will receive a 24 hour continuous infusion of intravenous theophylline.

Interventions: intervention 1: Theophylline
Intervention descriptions: intervention 1: 24 hour infusion of IV theophylline

Protocol document: