Conditions: Alcoholism Alcohol Abuse Smoking Alcohol Drinking
Keywords: alcohol-related disorders Cholinergic Drugs varenicline Chantix
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 131
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine whether varenicline is effective in the treatment of alcohol dependence in smokers.

Detailed description:
Building upon knowledge about the role of nicotinic acetylcholine receptors in alcohol drinking and smoking, varenicline, a smoking cessation treatment that targets these receptors, will be tested as a potential treatment for alcohol dependent smokers seeking alcohol treatment.

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Varenicline
Intervention descriptions: intervention 1: 0.5 mg once per day for Days 1 to 3, 0.5 mg twice per day for Days 4 to 7, then two 0.5 mg tablets (1 mg) twice per day

Protocol document: