Conditions: Cocaine Dependence
Keywords: Cocaine Dependence
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 58
Healthy volunteers: no

Brief summary:
This research will evaluate the impact of blocking central and peripheral glucocorticoid receptors on stress sensitivity and the risk of relapse to cocaine use in treatment-seeking cocaine-dependent individuals. Mifepristone (RU-486) will be the glucocorticoid antagonist used.

Detailed description:
This study attempts to reduce relapse risk by blocking glucocorticoid receptors, and thus allow some of the changes in the brain caused by cocaine to redress themselves

Arms:
arm 1: Mifepristone 600mg arm 2: Placebo

Interventions: intervention 1: Mifepristone intervention 2: placebo
Intervention descriptions: intervention 1: Mifepristone 600mg, 3x/wk for 4 weeks intervention 2: placebo

Protocol document: