Conditions: Cystic Fibrosis
Keywords: pharmacokinetics ceftazidime/avibactam
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 12
Healthy volunteers: no

Brief summary:
The purpose of this research study is to characterize the pharmacokinetics of intravenous ceftazidime/avibactam in patients with Cystic Fibrosis.

Detailed description:
Cystic fibrosis is a genetic disorder characterized by a chronic cycle of airway infection, obstruction, and inflammation leading to progressive loss of lung function and eventual respiratory failure. The principal pathogen is Pseudomonas aeruginosa which is present in the airways of 70% of adult patients with CF. Of particular concern is the increasing resistance observed to existing agents.

While ceftazidime has been the mainstay of treatment for many years, its efficacy is limited by reduced susceptibility. Ceftazidime/avibactam offers a potential advancement in the management of infections involving P. aeruginosa in CF due to its excellent activity, penetration into pulmonary secretions, and reduced potential for development of resistance.

Arms:
arm 1: Ceftazidime/avibactam 2.5gm IV q8h for 3 doses

Interventions: intervention 1: Ceftazidime/avibactam
Intervention descriptions: intervention 1: Ceftazidime/avibactam 2.5gm iv q8h for 3 doses

Protocol document: