Conditions: Abdominal Aortic Aneurysm (AAA)
Keywords: Abdominal Aortic Aneurysm AAA IL-1b Abdominal ultrasound
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 65
Healthy volunteers: no

Brief summary:
This study was designed to assess the safety, tolerability and efficacy of ACZ885 on aneurysmal growth rate in subjects with abdominal aortic aneurysms (AAA). The purpose of the study was to provide data to enable decisions regarding the further development of ACZ885 for subjects with abdominal aortic aneurysms. The design of this study addressed the primary objective of evaluating the change in aneurysmal size in subjects with AAA as a result of treatment with ACZ885.

Detailed description:

Arms:
arm 1: Participants received ACZ885 150 mg subcutaneously (s.c.) once per month for 12 months. arm 2: Participants received matching placebo to ACZ885 s.c. once per month for 12 months.

Interventions: intervention 1: ACZ885 intervention 2: Placebo
Intervention descriptions: intervention 1: ACZ885 150 mg liquid pre-filled syringes were administered s.c.. intervention 2: Matching placebo liquid pre-filled syringes were administered s.c..

Protocol document: