Conditions: Cognitive Decline
Keywords: Cognition
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 550
Healthy volunteers: no

Brief summary:
The purpose of this study is to see if a drug called lidocaine prevents cognitive injury (a decline in mental abilities) after heart surgery. Lidocaine is currently FDA approved and is commonly used for treating some heart rhythm disorders and for regional anesthesia (blocking nerves). The investigators are enrolling subjects in this research project to see if lidocaine will reduce the high incidence of cognitive injury seen after heart surgery. As part of this study, the investigators will also evaluate the relationship between cognitive injury and genetic makeup and the chemical changes in the subjects blood during and after surgery.

Detailed description:

Arms:
arm 1: Lidocaine infusion for 48 hours arm 2: Normal saline infusion for 48 hours

Interventions: intervention 1: Lidocaine intervention 2: Placebo
Intervention descriptions: intervention 1: Lidocaine versus placebo infusion for 48 hours intervention 2: Lidocaine versus placebo infusion for 48 hours

Protocol document: