Conditions: Arterial Dysfunction Chronic Kidney Disease
Keywords: chronic kidney disease vitamin D deficiency
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 128
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine whether nutritional (cholecalciferol) or active vitamin D (calcitriol) supplementation improves vascular endothelial function in patients with stage IIIB and IV chronic kidney disease with vitamin D insufficiency or deficiency. The investigators hypothesize that the use of calcitriol supplementation will result in improved vascular endothelial function as compared to cholecalciferol supplementation.

Detailed description:

Arms:
arm 1: Cholecalciferol 4000 IU capsule by mouth daily x 1 month then 2000 IU capsule by mouth daily x 5 months arm 2: Calcitriol 0.25 mcg capsule by mouth daily x 1 month then 0.5 mcg capsule by mouth daily x 5 months

Interventions: intervention 1: Cholecalciferol intervention 2: Calcitriol
Intervention descriptions: intervention 1: None intervention 2: None

Protocol document: