Conditions: Dental Caries
Keywords: silver diamine fluoride diammine silver fluoride children
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 66
Healthy volunteers: yes

Brief summary:
This study is being conducted to test whether the use of diammine silver fluoride (also called silver diamine fluoride) hardens the cavity sufficiently so that it arrests.

Detailed description:
Phase III RCT with two arms: (1) 38% diammine silver fluoride; (2) distilled fluoride free water. Subjects are 200 preschool children in good general health with untreated tooth decay. Intervention is topical application of the study drug to the open cavity. Primary outcome is caries activity at 14-21 days.

Arms:
arm 1: Topical application of 38% diammine silver fluoride to active cavity arm 2: Topical application of fluoride free water to active cavity

Interventions: intervention 1: 38% diammine silver fluoride intervention 2: Water
Intervention descriptions: intervention 1: treatment of cavity with study agent intervention 2: Fluoride free, distilled water

Protocol document: