Conditions: Acute Ischemic Stroke
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 196
Healthy volunteers: no

Brief summary:
The primary study objective is to determine if subjects experiencing an acute ischemic stroke due to large vessel occlusion, treated with combined IV t-PA and Solitaire Revascularization Device within 6 hours of symptom onset have less stroke-related neurological disability (mRS) than those subjects treated with IV t-PA alone

Detailed description:

Arms:
arm 1: Dual IV tPA therapy and adjunctive treatment with the Solitaire revascularization device arm 2: Infusion of intravenous tissue plasminogen activator (IV t-PA)

Interventions: intervention 1: Intravenous (IV) recombinant human tissue plasminogen activator (rtPA) intervention 2: Solitaire revascularization device
Intervention descriptions: intervention 1: Standard therapy with Intravenous (IV) recombinant human tissue plasminogen activator (rtPA) intervention 2: Clot retrieval with the Solitaire revascularization device after patients have received standard therapy with intravenous tissue plasminogen activator

Protocol document: