Conditions: Perennial Allergic Rhinitis
Keywords: Rhinitis Allergic Rhinitis Nose Diseases Respiratory Tract Diseases Immune System Diseases Cholinergic Antagonists Cholinergic Agents Neurotransmitter Agents Histamine H1 Antagonists, Non-Sedating Histamine H1 Antagonists Histamine Antagonists Histamine Agents
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 608
Healthy volunteers: no

Brief summary:
This is a study to evaluate the efficacy and safety of desloratadine (MK-4117) in Japanese participants with perennial allergic rhinitis. The primary hypothesis is that desloratadine is superior to placebo after 2 weeks of treatment with regard to change from baseline in Total Nasal Symptom Score among Japanese participants with perennial allergic rhinitis.

Detailed description:

Arms:
arm 1: Participants receive one desloratadine 5 mg tablet and one placebo tablet orally once daily for up to 2 weeks arm 2: Participants receive two desloratadine 5 mg tablets orally once daily for up to 2 weeks arm 3: Participants receive two placebo tablets orally once daily for up to 2 weeks

Interventions: intervention 1: Desloratadine 5 mg intervention 2: Placebo
Intervention descriptions: intervention 1: Desloratadine 5 mg tablets intervention 2: Matching placebo to desloratadine 5 mg tablets

Protocol document: