Conditions: Coronary Artery Disease (CAD)
Keywords: Coronary Artery Disease (CAD) regadenoson pharmacologic stress
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 1147
Healthy volunteers: no

Brief summary:
The purpose of this study is to demonstrate that the strength of agreement between single photon emission computed tomography (SPECT) imaging with regadenoson following inadequate exercise stress testing and SPECT imaging with regadenoson alone is not inferior to the strength of agreement between two sequential regadenoson SPECT images without exercise.

Detailed description:

Arms:
arm 1: On Day 1 participants received regadenoson, 0.4 mg in a 5 mL intravenous bolus, 3 minutes after exercise while in walk recovery and then a stress SPECT MPI. One to 14 days later participants received regadenoson at rest and then a stress SPECT MPI. arm 2: On Day 1 participants received regadenoson, 0.4 mg in a 5 mL intravenous bolus (1 hour after exercise recovery), and then stress SPECT MPI. One to 14 days later participants received regadenoson at rest and then a stress SPECT MPI.

Interventions: intervention 1: Regadenoson intervention 2: Single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI)
Intervention descriptions: intervention 1: Administered as an intravenous (IV) bolus intervention 2: None

Protocol document: