Conditions: Tobacco Use Disorder
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 98
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine the timeframe (relative to a stress task) that is most effective at attenuating the increase in symptoms of tobacco craving and withdrawal that occur when smokers are presented with stressful situations.

Detailed description:

Arms:
arm 1: Subjects will receive the nicotine lozenge immediately prior to the stress task at one laboratory session and after the stress task at the other laboratory session arm 2: Subjects will receive the nicotine lozenge after the stress task during one laboratory session and immediately prior to the stress task at the other laboratory session arm 3: Subjects will receive the nicotine lozenge after the stress task during one laboratory session and 10 minutes prior to the stress task at the other laboratory session arm 4: Subjects will receive the nicotine lozenge 10 minutes prior to the stress task during one laboratory session and after the stress task at the other laboratory session

Interventions: intervention 1: Nicotine lozenge
Intervention descriptions: intervention 1: A single dose of nicotine lozenge will be given at various timepoints relative to completion of a somewhat stressful task

Protocol document: