Conditions: Transplant Rejection
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 45
Healthy volunteers: yes

Brief summary:
The purpose of this study is to determine the effects of belatacept on the pharmacokinetics of caffeine, losartan, omeprazole, dextromethorphan and midazolam

Detailed description:

Arms:
arm 1: Inje Cocktail consisting of (200 mg Caffeine, 50 mg losartan tablet, 40 mg Omeprazole capsule, 30 mg Dextromethorphan capsule and 5 mg Midazolam oral syrup) administered on Days 1, 4, 7 and 11

Belatacept 10 mg/kg Intravenous (IV) solution, administered on Day 4

Interventions: intervention 1: Caffeine intervention 2: Losartan intervention 3: Omeprazole intervention 4: Dextromethorphan intervention 5: Midazolam intervention 6: Belatacept
Intervention descriptions: intervention 1: None intervention 2: None intervention 3: None intervention 4: None intervention 5: None intervention 6: None

Protocol document: