Conditions: Disorders of Gallbladder, Biliary Tract and Pancrease
Keywords: Propofol Midazolam Meperidine
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 140
Healthy volunteers: yes

Brief summary:
The purpose of this study is to compare efficacy and safety of combination of propofol and midazolam with meperidine versus midazolam and meperidine for ambulatory ERCP

Detailed description:
ERCP is commonly done under sedation with midazolam and meperidine, however some studies showed varying outcomes of this conventional sedation for maintained sedation. Propofol is increasing used for sedation in gastrointestinal procedure owing to its rapid recovery profiles but the complications associated with propofol are not negligible.The investigators prospectively compare the efficacy, induction time, recovery time, patient satisfaction and side effect between propofol based and conventional sedations in patients undergoing ERCP.

Arms:
arm 1: both midazolam (1mg if aged \<= 70 years or 0.5mg in age \>70 years) and meperidine 20 mg were given intravenously at the initiation of sedation, Thereafter, an initial bolus of propofol 20 mg intravenously. Sedation was maintained with repeated dose of 5 to 10 mg propofol. arm 2: both midazolam 2 to 5 mg and meperidine 25 to 50 mg were given intravenously at the initiation of sedation. Sedation was maintained with repeated doses of 0.5 to 1.0 mg midazolam and 5 to 10 mg meperidine.

Interventions: intervention 1: Propofol intervention 2: Midazolam intervention 3: Meperidine
Intervention descriptions: intervention 1: Propofol is the sedative drug used as an additional sedation to one of the study arm. intervention 2: Midazolam is one of the two conventional sedative drugs included in both arms. intervention 3: Meperidine is one of the two conventional sedative drugs included in both arms.

Protocol document: