Conditions: Advanced Adult Hepatocellular Carcinoma Hepatocellular Carcinoma Metastatic
Keywords: Child-Pugh A to B7, Advanced/Metastatic Hepatocellular Carcinoma, AZD9150, Antisense Oligonucleotide Inhibitor of STAT3
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 58
Healthy volunteers: no

Brief summary:
This is a phase I/Ib open-label, multicentre study to assess the safety, tolerability, pharmacokinetics and preliminary anti-tumour activity of AZD9150 in patients with advanced/metastatic hepatocellular carcinoma.

Detailed description:
A Phase I/Ib, Open-Label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of AZD9150 in Patients with Advanced/Metastatic Hepatocellular Carcinoma.

Arms:
arm 1: There are two parts, dose escalation phase (Part A) and dose expansion phase (Part B).

Interventions: intervention 1: AZD9150
Intervention descriptions: intervention 1: Intravenous infusion over 3 hours.

Protocol document: