Conditions: Epilepsy
Keywords: Epilepsy antiepileptic drug polytherapy
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 56
Healthy volunteers: no

Brief summary:
This is a study to determine whether a combination of low dose lacosamide and levetiracetam is more effective than high dose levetiracetam in patients who have failed low dose levetiracetam.

Detailed description:

Arms:
arm 1: Participants received lacosamide 50 mg twice a day for one week followed by 100 mg twice daily added to low dose levetiracetam ≤1500 mg/day (polytherapy) for 6 months in patients with breakthrough seizures on low-dose levetiracetam. arm 2: Historical chart review of patients whose dose of levetiracetam was raised to high dose levetiracetam \>1500 mg/day (monotherapy) after a breakthrough seizure. No intervention was administered in the study.

Interventions: intervention 1: lacosamide intervention 2: levetiracetam
Intervention descriptions: intervention 1: Lacosamide maximum of 200 mg/day, to be titrated as follows:

* Week 1: 50 mg twice a day
* Beginning Week 2: 100 mg twice a day. intervention 2: Low dose ≤1500 mg/day, High dose \>1500 mg/day

Protocol document: