Conditions: Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Myelodysplastic Syndrome
Keywords: AML ALL MDS iron overload deferoxamine
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 5
Healthy volunteers: no

Brief summary:
The objective of this research study is to determine the safety and feasibility of chelation therapy with deferoxamine for patients with iron overload who are receiving a stem cell transplant. Patients who have iron overload prior to stem cell transplantation may have more toxicity from the transplantation procedure, and thus may benefit from an attempt at iron chelation pre- and peri-transplantation. In this study we are examining the use of deferoxamine starting 2 weeks to 3 months prior to transplantation and continuing through the preparative regimen.

Detailed description:
See above

Arms:
arm 1: Deferoxamine for \>=2 weeks prior to stem cells

Interventions: intervention 1: deferoxamine
Intervention descriptions: intervention 1: Given intravenously or subcutaneously over 8-12 hours daily for at least three weeks prior to transplantation date and continue until the day before the participant receives their donor's stem cells.

Protocol document: