Conditions: Cocaine Dependence
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 114
Healthy volunteers: no

Brief summary:
The medication modafinil has been shown to reduce cocaine use in some cocaine users. The investigators have shown that modafinil taken in the morning improves sleep in chronic cocaine users. The investigators hypothesize that the beneficial effects of modafinil in reducing cocaine use may be related to specific effects modafinil has on sleep. This study will measure sleep and cocaine use in cocaine dependent persons who are trying to stop using cocaine, and will test the connection between modafinil's effects on sleep and cocaine use.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Modafinil intervention 2: Cognitive Behavioral Therapy
Intervention descriptions: intervention 1: Modafinil 400mg PO QDaily following up-titration for \~8weeks intervention 2: Once weekly cognitive behavioral therapy for cocaine dependence

Protocol document: