Conditions: Hepatitis B, Chronic
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 629
Healthy volunteers: no

Brief summary:
The purpose of this study is to evaluate the effectiveness of entecavir plus adefovir combination therapy versus entecavir monotherapy or therapy with adefovir plus lamivudine

Detailed description:

Arms:
arm 1: With the option of adding tenofovir at week 48. (This does not apply to Korea) arm 2: None arm 3: None

Interventions: intervention 1: Entecavir intervention 2: Tenofovir intervention 3: Adefovir intervention 4: Lamivudine
Intervention descriptions: intervention 1: Tablets, Oral, 1mg, once daily, 100 weeks intervention 2: Tablets, Oral, 300 mg, once daily intervention 3: Tablets, Oral, 10mg, once daily, 100 weeks intervention 4: Tablets, Oral, 100mg, once daily, 100 weeks

Protocol document: