Conditions: Rheumatoid Arthritis
Keywords: rheumatoid arthritis etanercept methotrexate DMARDs
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 491
Healthy volunteers: no

Brief summary:
To compare the maintenance of efficacy of the combination of etanercept 50 mg once weekly plus methotrexate with or without other disease modifying antirheumatic drugs therapy with that of methotrexate with or without other disease modifying antirheumatic drugs therapy at Week 52 in subjects with moderately to severely active rheumatoid arthritis who have achieved low disease activity after 24 weeks of therapy with open label etanercept 50 mg once weekly plus MTX with or without other disease modifying antirheumatic drugs therapy.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Etanercept intervention 2: placebo
Intervention descriptions: intervention 1: etanercept 50mg once weekly + methotrexate with or without other DMARDs intervention 2: etanercept placebo once weekly + methotrexate with or without other DMARDs

Protocol document: