Conditions: Major Depressive Disorder
Keywords: Major Depressive Disorder MDD Monotherapy Inadequate Response to Antidepressant Therapy
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 145
Healthy volunteers: no

Brief summary:
The purpose of this study is to assess the safety and effect of TC-5214 as a single therapy in patients with major depressive disorder who exhibit inadequate response to antidepressants.

Detailed description:

Arms:
arm 1: TC-5214, 1 mg BID arm 2: TC-5214, 4 mg BID arm 3: Duloxetine 60 mg Q Day arm 4: Placebo

Interventions: intervention 1: TC-5214 intervention 2: Duloxetine intervention 3: Placebo
Intervention descriptions: intervention 1: Tablet, oral, twice daily for 8 weeks intervention 2: Capsule, oral, once daily intervention 3: Tablet, oral, twice daily for 8 weeks

Protocol document: