Conditions: Febrile Neutropenia
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 36
Healthy volunteers: no

Brief summary:
The purpose of this study is to evaluate the benefits and side effects of daptomycin compared to placebo for the treatment of neutropenic fever.

Detailed description:
To determine whether the percentage of neutropenic subjects that become afebrile by five days after fever first develops is higher when daptomycin compared to placebo is added at the same time as anti gram-negative therapy. The five day time point is selected because it is at this point where it is recommended to add antifungal therapy to the treatment regimen if the patient is still febrile.

Arms:
arm 1: Daptomycin intravenous 8mg/kg once per day 5-10 days. arm 2: Saline solution

Interventions: intervention 1: Daptomycin intervention 2: Saline Placebo intervention 3: Daptomycin
Intervention descriptions: intervention 1: 8 MG/KG IV intervention 2: 50 ml normal saline once daily intervention 3: 8 mg/kg once daily

Protocol document: