Conditions: Moderate to Severe Rheumatoid Arthritis
Keywords: rheumatoid arthritis etanercept arthritis adalimumab failure to respond loss of response to adalimumab ACR20 methotrexate Swollen joints tender joints
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 90
Healthy volunteers: no

Brief summary:
To evaluate the efficacy of etanercept in adults with moderate-to-severe rheumatoid arthritis (RA) who did not respond to or lost a satisfactory response to adalimumab when used as their first biologic agent.

Detailed description:

Arms:
arm 1: Participants received etanercept 50 mg administered subcutaneously once a week with methotrexate for 24 weeks

Interventions: intervention 1: Etanercept intervention 2: Methotrexate
Intervention descriptions: intervention 1: Administered by subcutaneous injection intervention 2: Background methotrexate at least 15 mg weekly

Protocol document: