Conditions: Heart Failure
Keywords: Heart failure with preserved ejection fraction Diastolic heart failure Aerobic exercise performance
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 12
Healthy volunteers: no

Brief summary:
This will be a randomized, double-blind, crossover pilot study to measure the safety and feasibility of Interleukin-1 (IL-1) blockade with Anakinra in patients with stable heart failure with preserved ejection fraction.

Detailed description:

Arms:
arm 1: Treatment with daily subcutaneous injections of Anakinra 100 mg arm 2: Treatment with daily subcutaneous injection of placebo

Interventions: intervention 1: Anakinra intervention 2: Placebo
Intervention descriptions: intervention 1: Anakinra 100 mg daily subcutaneous injection intervention 2: Placebo daily subcutaneous injection

Protocol document: