Conditions: Healthy
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 34
Healthy volunteers: yes

Brief summary:
The purpose of this study is to evaluate the effect of increased stomach pH on how much evacetrapib is found in the blood stream and how long the body takes to get rid of it when given to healthy participants. Information about any side effects that may occur will also be collected.

There are two parts to the study. Participation in both parts will be required.

The study will last approximately 30 days, not including screening.

Detailed description:

Arms:
arm 1: Single oral dose of evacetrapib administered alone on Day 1 of Period 1. arm 2: In Period 2, participants will receive 40 mg oral dose of Omeprazole once daily (QD) on Days 8 through 20.

Evacetrapib will be co-administered once, orally on Day 14.

Interventions: intervention 1: Evacetrapib intervention 2: Omeprazole
Intervention descriptions: intervention 1: Administered orally intervention 2: Administered orally

Protocol document: