Conditions: Type 2 Diabetes Mellitus
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 26
Healthy volunteers: no

Brief summary:
This study compared the effects of delayed-release metformin (Met DR, EFB0027) administered once daily in the morning (qAM), administered once daily in the evening (qPM), and administered twice daily (BID) on circulating glucose concentrations and metformin pharmacokinetics (PK) in subjects with type 2 diabetes mellitus (T2DM).

Detailed description:

Arms:
arm 1: Two doses of 500 mg metformin delayed-release arm 2: One dose of 1000 mg metformin delayed-release in the morning arm 3: One dose of 1000 mg metformin delayed-release in the evening

Interventions: intervention 1: Met DR
Intervention descriptions: intervention 1: metformin delayed-release tablets

Protocol document: