Conditions: Intracranial Neurosurgery
Keywords: dexmedetomidine propofol cerebral blood flow brain oxygenation
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 44
Healthy volunteers: no

Brief summary:
The investigators will evaluate the effects of dexmedetomidine and propofol on cerebral blood flow and brain oxygenation during Deep Brain Stimulation (DBS) surgery. Specifically, the investigators will test the hypothesis that dexmedetomidine is non-inferior to propofol for cerebral blood flow as measured by transcranial Doppler and brain oxygenation as measured by near-infrared spectroscopy.

Detailed description:

Arms:
arm 1: Subjects will be sedated with propofol. arm 2: Subjects will be sedated with dexmedetomidine.

Interventions: intervention 1: dexmedetomidine intervention 2: propofol
Intervention descriptions: intervention 1: Patients assigned to dexmedetomidine will be given a mg/kg bolus over 10-20 minutes; subsequently, an infusion will be titrated to between 0.4-0.6 mcg/kg/hr to maintain an adequate level of sedation during the procedure. intervention 2: Patients assigned to propofol will be given an infusion dose of 50-75 µ/kg/min which will be titrated to the patient's response

Protocol document: