Conditions: Diabetes Mellitus Type 2
Keywords: DM type 2 Hypogonadism Testosterone AndroGel
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 49
Healthy volunteers: no

Brief summary:
This is to study the effect of replacing testosterone on different inflammatory cells in type 2 diabetics with low testosterone levels.

Detailed description:
Type 2 diabetes is an atherosclerotic, pro-inflammatory and pro-oxidative stress. Hypogonadism( low testosterone) is also associated with increased levels of inflammatory mediators and atherosclerosis.

This project is about studying the effect of testosterone replacement on different inflammatory cells in blood and urine. It will also compare the dose dependent effect on inflammatory cells. This also involves comparing level of inflammation in hypogonadic diabetic males treated with testosterone with those not treated with any replacement therapy.

This study involves applying AndroGel for 8 wks and studying effects during this time and thereafter.

Arms:
arm 1: androgel 5g arm 2: androgel 10g arm 3: placebo

Interventions: intervention 1: androgel intervention 2: androgel 10g intervention 3: placebo
Intervention descriptions: intervention 1: androgel 5g intervention 2: androgel 10g intervention 3: placebo

Protocol document: