Conditions: Plaque Psoriasis
Keywords: Mild to Moderate Chronic Plaque Psoriasis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 60
Healthy volunteers: no

Brief summary:
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of 12 weeks of treatment with Apo805K1 in subjects with moderate to severe chronic plaque psoriasis.

Detailed description:
A) To evaluate the safety and tolerability of 12 weeks of treatment with Apo805K1

B) To evaluate the pharmacokinetics of Apo805K1 following daily administration for 14 days

C) To evaluate the efficacy and pharmacodynamics of Apo805K1

Arms:
arm 1: None arm 2: None arm 3: None arm 4: None

Interventions: intervention 1: Apo805K1
Intervention descriptions: intervention 1: Sequential parallel dose escalation.

Protocol document: