Conditions: Acne
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 266
Healthy volunteers: no

Brief summary:
Non-inferiority, randomized, controlled, multi-center, investigator-blind, parallel-group comparison study in subjects with severe acne vulgaris on the face.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Epiduo/Tactuo intervention 2: vehicle gel intervention 3: doxycycline 200mg intervention 4: Isotretinoin
Intervention descriptions: intervention 1: topical to the face, once daily in the evening intervention 2: topical to the face, once daily in the evening intervention 3: oral, 2 capsules once daily in the morning with aglass of water and with food intervention 4: oral, 0.5mg/kg/day for a period of four weeks, adjusted to 1 mg/kg/day for the four following months.

Protocol document: