Conditions: Colorectal Surgery
Keywords: opioid Fentanyl Anesthetic adjuvant Pain management Perioperative outcomes Constipation Ileus Colorectal
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 21
Healthy volunteers: no

Brief summary:
The purpose of this research is to evaluate the effectiveness of ketamine as an analgesic adjuvant in decreasing the narcotic (opioids) analgesics during surgery, on pain management and on the later recovery after surgery in patients undergoing colorectal surgery.

Detailed description:
Adjuvant is a drug that has few or no pharmacological effects by itself, but may increase the effectiveness or strength of other drugs when given at the same time.

Arms:
arm 1: Loading and Infusion:

Saline at infusion rate calculated and adjusted for weight to match ketamine bolus-infusion rate arm 2: Loading: 0.5 mg/Kg Infusion: 5 mcg/kg/min arm 3: Loading: 1 mg/Kg Infusion: 10 mcg/kg/min

Interventions: intervention 1: Placebo intervention 2: Ketamine high-dose intervention 3: Ketamine low-dose
Intervention descriptions: intervention 1: Loading and Infusion: Saline at infusion rate calculated and adjusted for weight to match ketamine bolus-infusion rate intervention 2: Loading: 1 mg/Kg Infusion: 10 mcg/kg/min intervention 3: Loading: 0.5 mg/Kg Infusion: 5 mcg/kg/min

Protocol document: