Conditions: Hypotension Shock
Keywords: hypotension vasopressors titration tissue perfusion organ failure
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 120
Healthy volunteers: no

Brief summary:
The purpose of this research study is to determine if it is better to give vasopressors to patients to maintain a higher blood pressure target versus a lower blood pressure target. This study is important because the information we find out will help us know how best to administer vasopressors in patients with shock in the ICU.

Detailed description:
Patients who are admitted to the intensive care unit (ICU) commonly suffer from shock, a condition that causes life-threatening low blood pressure. Low blood pressure makes it difficult for the body to deliver blood to all of its organs. The standard treatment doctors in the ICU use for their patients is to give medications that help increase blood pressure. These medications are called vasopressors. There can be side effects related to using vasopressors. The purpose of this research study is to determine if it is better to give vasopressors to patients to maintain a higher blood pressure target versus a lower blood pressure target. This study is important because the information we find out will help us know how best to administer vasopressors in patients with shock in the ICU.

Arms:
arm 1: In the liberal approach group, we will titrate vasopressors to maintain mean arterial pressures between 75 and 80 mmHg. arm 2: We will titrate vasopressors to maintain mean arterial pressures between 60 and 65 mmHg.

Interventions: intervention 1: Vasopressors
Intervention descriptions: intervention 1: None

Protocol document: