Conditions: Menopause Depression Hot Flashes
Keywords: Hot Flashes Sleep disturbance Lupron Menopause
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 29
Healthy volunteers: yes

Brief summary:
We plan to enroll premenopausal women in a trial investigating the impact of hot flashes developed in response to an injection of a gonadotropin-releasing hormone agonist (GnRHa), leuprolide (brand name: Lupron), on sleep disruption and mood. This study is designed to mimic the menopause transition. We will collect data on sleep disruption and mood changes to assess their relationship to the development of hot flashes.

Detailed description:

Arms:
arm 1: We will be administering an injection of leuprolide acetate (a GnRH agonist) to all participants.

Interventions: intervention 1: leuprolide
Intervention descriptions: intervention 1: Leuprolide acetate is a widely used GnRH agonist. In this protocol, leuprolide will be administered at a dose routinely used for treatment of endometriosis and uterine fibroids in women (one 3.75-mg intramuscular injection).

Protocol document: