Conditions: Healthy Volunteer
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 56
Healthy volunteers: yes

Brief summary:
The purposes of this study are to look at safety, how well the study drug (LY110140) is tolerated, and how much of the study drug gets into the blood stream when given as single dose (SD) and multiple doses (MD) to healthy Japanese male participants. Participants will participate in SD portion for approximately 6 weeks and in MD portion for approximately 10 weeks.

Detailed description:

Arms:
arm 1: 5 mg administered once in the fasted state on Day 1 arm 2: 20 mg administered once in the fasted state on Day 1 arm 3: 40 mg administered once in the fasted state on Day 1 arm 4: Placebo once daily oral dosing for 28 consecutive days arm 5: 20 mg once daily oral dosing for 28 consecutive days arm 6: 40 mg once daily oral dosing for 28 consecutive days

Interventions: intervention 1: LY110140 intervention 2: Placebo
Intervention descriptions: intervention 1: Administered orally as capsules intervention 2: Administered orally as capsules in the placebo arm and to maintain the blind in the 20 mg LY110140 (MD) arm

Protocol document: