Conditions: Psoriasis Plaque Psoriasis
Keywords: Psoriasis Skin Diseases Halobetasol Vasoconstrictor Agents Therapeutic Uses Pharmacologic Actions Anti-Inflammatory Agents Physiological Effects of Drugs
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 72
Healthy volunteers: no

Brief summary:
This is a double-blind, multicenter, vehicle-controlled, parallel group comparison study to determine and compare the efficacy and safety of HBP Lotion 0.05% and Vehicle Lotion applied twice daily for two weeks in subjects with moderate to severe plaque psoriasis. Eligible subjects will be randomized (1:1) to one of two treatment groups - HBP Lotion 0.05% or Vehicle Lotion. The maximum amount of test article to be applied per week should not exceed 50 grams.

Detailed description:

Arms:
arm 1: Topical lotion, applied twice daily arm 2: Topical lotion, applied twice daily

Interventions: intervention 1: Halobetasol Propionate Lotion 0.05% intervention 2: Placebo
Intervention descriptions: intervention 1: Apply twice daily for 1-2 weeks, not to exceed 50 grams per week intervention 2: None

Protocol document: