Conditions: Retinoblastoma
Keywords: Retinoblastoma carboplatin
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 26
Healthy volunteers: no

Brief summary:
This study will evaluate a uniform chemotherapy protocol for nonmetastatic extraocular retinoblastoma

Detailed description:
This study will be a phase 4 open label interventional case series. Patients with retinoblastoma will be receive chemotherapy with or without periocular injections of carboplatin at a dose of 20mg/2 ml. Patients will receive chemotherapy on a monthly basis for a total duration of therapy of 6 months. Patients will be followed for 18 months .

Arms:
arm 1: CEV chemotherapy(CEV Chemotherapy:vincristine,1.5mg/m2;carboplatin,560mg/ m2;etoposide,150 mg/ m2.monthly for the first six months) together with/without 20mg/2ml carboplatin periocular injection

Interventions: intervention 1: carboplatin periocular injection intervention 2: CEV chemotherapy
Intervention descriptions: intervention 1: chemotherapy together with/without 20mg/2ml carboplatin periocular injection intervention 2: vincristine,1.5mg/m2;carboplatin,560mg/ m2;etoposide,150 mg/ m2

Protocol document: