Conditions: Anemia Kidney Disease
Keywords: anemia chronic kidney disease CKD chronic renal insufficiency renal impairment erythropoietin safety efficacy tolerability pharmacokinetics
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 93
Healthy volunteers: no

Brief summary:
The purpose of this study is to evaluate the dose response (efficacy), pharmacodynamic response, pharmacokinetics, safety, and tolerability of orally administered AKB-6548 in pre-dialysis participants with anemia with repeat dosing for 42 days.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None arm 4: None arm 5: None

Interventions: intervention 1: AKB-6548 intervention 2: Placebo
Intervention descriptions: intervention 1: oral dose administered once daily for 42 days intervention 2: oral Placebo administered once daily for 42 days

Protocol document: