Conditions: Pain Osteoarthritis
Keywords: placebo pain osteoarthritis
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 21
Healthy volunteers: no

Brief summary:
This is a two week,single-blind study evaluating pain response and changes in brain imaging upon treatment with placebo in people with knee OA.

Detailed description:
In this study, all the participants will be receiving placebo. However this study will be single blinded in that participants will be told that they will be given a pill that may or may not help with their pain. The researcher, however, will know that all participants are receiving placebo

At the initial visit, participants will undergo screening to determine that they meet all inclusion and exclusion criteria. They will sign consent and then complete pain assessment instruments as well as one high resolution anatomical scan (T1) and one functional scan (a resting scar) in a 3 Tesla magnet. A single scanning session comprised of a 10 minute functional scan (a resting scan) will be done two weeks from the first scan and pain assessment instruments will be completed at this visit as well. After finishing this second scan (done two weeks after the initial scan), the participants will have completed the study.

Arms:
arm 1: placebo capsule

Interventions: intervention 1: Duloxetine intervention 2: Placebo Oral Tablet
Intervention descriptions: intervention 1: Duloxetine Delayed-Release Capsules: 30mg/day for 1 week ; 60mg/day for the remaining time intervention 2: Lactose capsule

Protocol document: