Conditions: Premature Pubarche
Keywords: Puberty Hormones
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 4
Healthy volunteers: no

Brief summary:
The primary objective of this study is to determine the safety and efficacy of metformin in lowering serum DHEAS levels in girls with premature pubarche and secondary, to observe changes in hormones associated with pubertal development including gonadotropins, sex steroids, insulin, adipocytokines, and growth factors.

Detailed description:

Arms:
arm 1: 2 pills per day for 12 months arm 2: 2 212.5mg pill/day for 12 months

Interventions: intervention 1: sugar pill intervention 2: Metformin, glucophage
Intervention descriptions: intervention 1: 2 pills per day for 12 months intervention 2: 2 212.5mg pills/day for 12 months

Protocol document: