Conditions: Healthy
Allocation: NON_RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 48
Healthy volunteers: yes

Brief summary:
To investigate the pharmacokinetic and pharmacodynamic interaction of dabigatran and ticagrelor under steady state conditions; to investigate the effect of staggered administration of ticagrelor loading dose on dabigatran exposure (in Part II)

Detailed description:

Arms:
arm 1: multiple doses of dabigatran (alone) arm 2: concomitant administration of dabigatran and ticagrelor arm 3: staggered administration of ticagrelor and dabigatran

Interventions: intervention 1: dabigatran etexilate intervention 2: dabigatran etexilate intervention 3: ticagrelor intervention 4: ticagrelor intervention 5: ticagrelor intervention 6: dabigatran etexilate
Intervention descriptions: intervention 1: multiple doses of dabigatran intervention 2: medium dose dabigatran intervention 3: loading dose of ticagrelor intervention 4: multiple doses of ticagrelor intervention 5: loading dose of ticagrelor intervention 6: single dose of dabigatran

Protocol document: