Conditions: Arrhythmia
Keywords: Atrial refractoriness cardiac electrophysiology IKACh
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 20
Healthy volunteers: no

Brief summary:
Medical Products Agency

Detailed description:
* A Multi-Centre, Double-Blind, Randomised, Placebo-Controlled Phase II Study to Assess the Effects on Atrial and Ventricular Refractoriness of an Intravenous Infusion of AZD2927 in Patients Undergoing an Invasive Electrophysiological Procedure.
* The study has an adaptive design. In the 1st dose group the planned number of randomised patients is 24. The tentative number of randomised patients in the optional 2nd dose group is 12, 24 or 36 and thus a total maximum of 60 patients will be randomised in the study.

Arms:
arm 1: A single dose of AZD2927 administered as an iv infusion arm 2: A single dose of placebo administered as an iv infusion

Interventions: intervention 1: AZD2927 intervention 2: Placebo
Intervention descriptions: intervention 1: A single dose of AZD2927 administered as an iv infusion intervention 2: A single dose of placebo administered as an iv infusion

Protocol document: