Conditions: Cocaine Dependence
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 179
Healthy volunteers: no

Brief summary:
The objective of this study is to evaluate the safety and efficacy of Nepicastat in improving the number of subjects that achieve abstinence from cocaine and reducing cocaine use in subjects with cocaine dependence.

Detailed description:

Arms:
arm 1: Nepicastat 120mg and 100mg riboflavin (once per day) for 11 weeks arm 2: Placebo capsule containing 100mg riboflavin (once per day) for 11 weeks.

Interventions: intervention 1: Nepicastat intervention 2: Placebo
Intervention descriptions: intervention 1: 120 mg of active drug and 100mg of riboflavin daily for 11 weeks or matching placebo containing 100mg of riboflavin daily for 11 weeks. intervention 2: None

Protocol document: