Conditions: Obesity
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 13
Healthy volunteers: no

Brief summary:
The goal of this study is to determine whether one week of phentermine compared to placebo administration results in changes in food intake during a laboratory meal.

Detailed description:
This study aims to explore whether short-term measures of eating behavior can be related to later, longer-term weight loss. In a double-blind, randomized fashion, participants will be asked to take study medication for three weeks: one week of phentermine and two weeks of placebo. At the end of the first and third weeks, participants will be asked to participate in a range of eating behavior studies. Following this three-week, double-blind phase, participants will be offered 6 months of open treatment for weight loss.

Arms:
arm 1: In this arm, participants receive 37.5mg phentermine for one week followed by 2 weeks of placebo.

Other names for phentermine:

adipex ionamin arm 2: In this arm, participants receive Placebo (for 37.5mg phentermine) for two weeks followed by phentermine 37.5mg for 7 days.

Interventions: intervention 1: Phentermine intervention 2: placebo
Intervention descriptions: intervention 1: After 7 days of phentermine 37.5 mg administration, food intake should be less than after 14 days of placebo. intervention 2: Food intake as measured by a laboratory study should be greater after 7 days of placebo administration compared to seven days of phentermine administration.

Protocol document: