Conditions: Non-cancer Pain Opioid Induced Constipation
Keywords: Opioid induced constipation/prucalopride chronic non-cancer pain Subjects with chronic non-cancer pain suffering from OIC
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 174
Healthy volunteers: no

Brief summary:
The study will evaluate the efficacy, safety and tolerability of prucalopride over 12 weeks of treatment in subjects aged 18 years and older with chronic non-cancer pain, suffering from opioid induced constipation.

Detailed description:

Arms:
arm 1: placebo arm 2: prucalopride

Interventions: intervention 1: placebo intervention 2: prucalopride
Intervention descriptions: intervention 1: placebo intervention 2: 1 or 2 mg prucalopride once daily before breakfast

Protocol document: