Conditions: Cocaine Dependence
Keywords: cocaine modafinil self-administration DRD4
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 8
Healthy volunteers: no

Brief summary:
Modafinil has been reported to reduce cocaine use in a clinical sample of infrequent users (2 days/week), but the effects of modafinil on cocaine self-administration in the laboratory have not been studied. The present study investigated the effects of modafinil maintenance on cocaine self-administration by frequent users (4 days/week) under controlled laboratory conditions. During this 48-day double-blind, crossover design study, the effects of modafinil maintenance (0, 200, and 400mg/day) on response to smoked cocaine (0, 12, 25, and 50 mg) were examined in nontreatment seeking cocaine-dependent individuals (n = 8).

Detailed description:

Arms:
arm 1: Participants were maintained on modafinil (0 mg/day) for 15 days, and underwent a dose response of cocaine. arm 2: Participants were maintained on modafinil (200 mg/day) for 15 days, and underwent a dose response of cocaine. arm 3: Participants were maintained on modafinil (400 mg/day) for 15 days, and underwent a dose response of cocaine.

Interventions: intervention 1: Modafinil 0 mg intervention 2: Modafinil 200 mg intervention 3: Modafinil 400 mg intervention 4: Cocaine 0 mg intervention 5: Cocaine 12 mg intervention 6: Cocaine 25 mg intervention 7: Cocaine 50 mg
Intervention descriptions: intervention 1: Modafinil (0 mg/day) intervention 2: Modafinil (200 mg/day) intervention 3: Modafinil (400 mg/day) intervention 4: Cocaine (0 mg/day) intervention 5: Cocaine (12 mg/day) intervention 6: Cocaine (25 mg/day) intervention 7: Cocaine (50 mg/day)

Protocol document: