Conditions: PONV
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 364
Healthy volunteers: no

Brief summary:
A comparison of the efficacy of APD421 and placebo in the prevention of PONV in patients at moderate-to-high risk of PONV.

Detailed description:

Arms:
arm 1: APD421 (amisulpride), at 5mg given by single intravenous (IV) administration by slow push over one minute at induction of anaesthesia. arm 2: Matching placebo given by single IV administration by slow push over one minute at induction of anaesthesia

Interventions: intervention 1: APD421- Amisulpride for IV injection intervention 2: Placebo
Intervention descriptions: intervention 1: APD421 ( Amisulpride) at 5mg given by single intravenous (IV) administration, by slow push over one minute, at induction of anaesthesia intervention 2: Matching Placebo given by single intravenous (IV) administration, by slow push over one minute, at induction of anaesthesia

Protocol document: