Conditions: Atherosclerosis Coronary Artery Disease
Keywords: Atherosclerosis Pioglitazone Atorvastatin PET CT
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 41
Healthy volunteers: no

Brief summary:
This study is a prospective randomized clinical trial and to compare the antiinflammatory effect of atorvastatin single therapy and atorvastatin and pioglitazone combination therapy in carotid arteries of stable and unstable angina patients by PET/CT.

Detailed description:

Arms:
arm 1: After the subject take PET CT, he or she is randomized to either " Atorvastatin 20 mg" group or " Atorvastatin 20 mg+ Pioglitazone 30 mg". The " Atorvastatin 20 mg" group is to take atorvastatin 20 mg and take follow up PET CT in 3 months arm 2: After the subject take PET CT, he or she is randomized to either " Atorvastatin 20 mg" group or " Atorvastatin 20 mg+ Pioglitazone 30 mg". The " Atorvastatin 20 mg + Pioglitazone 30 mg" group is to take atorvastatin 20 mg + pioglitazone 30 mg and take follow up PET CT in 3 months

Interventions: intervention 1: Atorvastatin 20mg intervention 2: Atorvastatin 20 mg + Pioglitazone 30 mg
Intervention descriptions: intervention 1: 20 mg QD for 3 months intervention 2: atorvastatin 20 mg plus pioglitazone 30 mg QD for 3 months

Protocol document: