Conditions: Ocular Hypertension Open Angle Glaucoma
Keywords: Intraocular pressure visual field Ocular hypertension or open angle glaucoma
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 85
Healthy volunteers: no

Brief summary:
In this double-masked, vehicle-controlled, dose-response study, subjects will be randomized to receive AR-13324 Ophthalmic Solution 0.01%, 0.02%, and 0.04% or its vehicle (one eye), once daily (QD)in the morning (AM) for 7 days. The first dose and last dose will be administered in the clinic. Ocular safety and ocular hypotensive efficacy will be evaluated in the clinic throughout the study.

Detailed description:

Arms:
arm 1: 1 drop to study eye once daily arm 2: 1 drop to study eye once daily arm 3: 1 drop to study eye once daily arm 4: 1 drop to study eye once daily

Interventions: intervention 1: AR-13324 Ophthalmic Solution 0.01% intervention 2: AR-13324 Ophthalmic Solution 0.02% intervention 3: AR-13324 Ophthalmic Solution 0.04% intervention 4: AR-13324 Ophthalmic Solution Vehicle
Intervention descriptions: intervention 1: Administered to study eye, once daily (QD) in the morning (AM) for 7 days intervention 2: Administered to study eye, QD AM for 7 days intervention 3: Administered to study eye, QD AM for 7 days intervention 4: Administered to study eye, QD AM for 7 days

Protocol document: