Conditions: Alcohol Sensitivity
Keywords: Broccoli sprouts alcohol sensitivity sulforaphane alcohol metabolism in the Asian Community
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 30
Healthy volunteers: yes

Brief summary:
This study is designed to determine whether Asians who are especially sensitive to alcohol exposure can be protected by boosting their activities of an alcohol disposing enzyme. This will be accomplished by administering broccoli sprouts that are rich in an agent that increases protective enzyme activity. The test system involves applying alcohol patches to the skin and measuring skin redness.

Detailed description:

Arms:
arm 1: Each subject will act as his/her own control and receive both treatment and placebo on adjacent skin regions. arm 2: Each subject will act as his/her own control and receive both treatment and placebo on adjacent skin regions.

Interventions: intervention 1: Broccoli Sprout Extract intervention 2: Placebo
Intervention descriptions: intervention 1: 150 nanomol of sulforaphane/cm2 of skin in 80% acetone for 3 applications on 3 successive days prior to alcohol challenge intervention 2: 80% acetone

Protocol document: