Conditions: Parkinson's Disease Motor Fluctuations
Keywords: Parkinson's disease PD stage2/3Parkinson's Advanced Parkinson's Disease with Motor Fluctuations
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 34
Healthy volunteers: no

Brief summary:
The primary objective of this study is to explore the efficacy and tolerability of DM-1992 compared to a standard carbidopa/Levodopa Immediate-Release (CD/LD IR) tablet (Sinemet IR) as measured by:

* "ON" time with no dyskinesia or non-troublesome dyskinesia
* "OFF" time

Detailed description:

Arms:
arm 1: DM-1992, a gastric-retentive extended-release tablet containing 72.5mg carbidopa (CD) and 230mg levodopa (LD) arm 2: An Immediate-release (IR) tablet containing 25mg carbidopa (CD) and 100mg levodopa (LD)

Interventions: intervention 1: DM-1992 intervention 2: Sinemet IR
Intervention descriptions: intervention 1: 72.5mg carbidopa/230mg levodopa intervention 2: Immediate-release tablet containing 25mg carbidopa and 100mg levodopa

Protocol document: