Conditions: Oral Hygiene
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 62
Healthy volunteers: yes

Brief summary:
This study will evaluate the effect of experimental sodium fluoride-silica dentifrice formulations, with and without zinc, on remineralization of enamel in situ. Following the remineralization phase, the acid resistance of the new mineral formed will be assessed. Fluoride uptake during the remineralization phase will also be measured.

Detailed description:

Arms:
arm 1: Non-zinc, 1426ppm fluoride as sodium fluoride in a silica gel base arm 2: Non-zinc, 1150ppm fluoride as sodium fluoride in a silica gel base arm 3: Non-zinc, 250ppm fluoride as sodium fluoride in a silica gel base arm 4: Zinc base A, 1426ppm fluoride as sodium fluoride in a silica gel base arm 5: Zinc base B, 1426ppm fluoride as sodium fluoride in a silica gel base arm 6: Non-zinc, 0ppm fluoride in a silica gel base

Interventions: intervention 1: Sodium fluoride (1426 ppm) intervention 2: Sodium fluoride (1150 ppm) intervention 3: Sodium fluoride (250 ppm) intervention 4: Sodium fluoride (1426 ppm) + zinc base A intervention 5: Sodium fluoride (1426 ppm) + zinc base B intervention 6: Fluoride (0 ppm)
Intervention descriptions: intervention 1: Non-zinc, 1426ppm fluoride as sodium fluoride in a silica gel base intervention 2: Non-zinc, 1150ppm fluoride as sodium fluoride in a silica gel base intervention 3: Non-zinc, 250ppm fluoride as sodium fluoride in a silica gel base intervention 4: Zinc base A, 1426ppm fluoride as sodium fluoride in a silica gel base intervention 5: Zinc base B, 1426ppm fluoride as sodium fluoride in a silica gel base intervention 6: Non-zinc, 0ppm fluoride in a silica gel base

Protocol document: