Conditions: Chronic Obstructive Pulmonary Disease With (Acute) Exacerbation
Keywords: COPD Chronic obstructive pulmonary disease Roflumilast
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 81
Healthy volunteers: no

Brief summary:
The purpose of this trial is to investigate if roflumilast can reduce the neutrophilic inflammation at acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD). In addition, the potential benefit of roflumilast on severity and recovery periods of acute COPD exacerbations will be assessed using patient diaries and questionnaires.

Detailed description:
Participants will be asked whether they agree to participate in the measurements of arterial stiffness. Participants who agree will be included in the substudy, with the target of 60 patients with arterial stiffness measurements to complete the trial.

Study was terminated due to difficulty in identifying further eligible patients for this exploratory study within a reasonable time.

Arms:
arm 1: added on to standard therapy for acute COPD exacerbations arm 2: added on to standard therapy for acute COPD exacerbations

Interventions: intervention 1: Roflumilast intervention 2: Placebo
Intervention descriptions: intervention 1: 500 µg tablet, od, oral administration in the morning after breakfast intervention 2: tablet, od, oral administration in the morning after breakfast

Protocol document: