Conditions: Papulopustular Rosacea
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 962
Healthy volunteers: no

Brief summary:
Study objectives:

* To compare efficacy and safety of Ivermectin 1% cream versus metronidazole 0.75% cream in subjects with papulopustular rosacea after 16-week topical treatment.
* And to compare, for subjects initially successfully treated by 16 weeks treatment, Ivermectin 1 % cream versus metronidazole 0.75% cream during a 36-week extension period by assessing, the time of first relapse, the relapse rate, and the number of days free of treatment

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Ivermectin 1% cream intervention 2: Metronidazole 0.75% cream
Intervention descriptions: intervention 1: Ivermectin 1% cream applied once daily on the face during 16-week plus 36-week extension period. intervention 2: Metronidazole 0.75% cream applied twice daily on the face during 16-week plus 36-week extension period.

Protocol document: