Conditions: Alcohol Dependence Cocaine Dependence
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 15
Healthy volunteers: no

Brief summary:
This is a Phase II within-subjects double-blind placebo-controlled human laboratory study. The purpose of the study is to determine the efficacy of varenicline (Chantix) for reducing cue-induced cocaine and alcohol craving.

Detailed description:

Arms:
arm 1: Varenicline, oral administration for 1 week arm 2: Placebo, oral administration for 1 week

Interventions: intervention 1: Varenicline intervention 2: Placebo
Intervention descriptions: intervention 1: Varenicline, oral target dose of 1.0 mg BID, one week titration. intervention 2: Placebo

Protocol document: