Conditions: Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)
Keywords: SIADH
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 30
Healthy volunteers: no

Brief summary:
This is a study to evaluate how the body handles and metabolizes (PK) the various doses of the drug Tolvaptan, and what the effect (PD) of the various doses of Tolvaptan are on the content of "salt" in blood and urine

Detailed description:

Arms:
arm 1: tolvaptan 3.75 mg arm 2: tolvaptan 7.5 mg arm 3: tolvaptan 15 mg

Interventions: intervention 1: tolvaptan
Intervention descriptions: intervention 1: Subjects will receive a single dose of 3.75, 7.5 or 15 mg of tolvaptan on study Day 1

Protocol document: