Conditions: Cocaine Dependence
Keywords: cocaine dependence hiv prevention
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 94
Healthy volunteers: no

Brief summary:
The purpose of study is to determine if modafinil promotes cocaine abstinence and reduces high risk behavior in cocaine dependent subjects.

Detailed description:
The purpose of study is to determine if modafinil promotes cocaine abstinence and reduces HRB in cocaine dependent subjects. Modafinil (300 mg/day) or placebo will be administered in an 8-week double-blind trial to patients meeting diagnostic criteria for cocaine dependence in conjunction with Cognitive Behavioral Therapy (CBT).

Arms:
arm 1: modafinil plus CBT arm 2: placebo plus CBT

Interventions: intervention 1: Modafinil intervention 2: placebo intervention 3: Cognitive Behavioral Therapy (CBT)
Intervention descriptions: intervention 1: 300mg a day for 8 weeks intervention 2: placebo pills for 8 weeks intervention 3: Weekly cognitive behavioral therapy sessions for a period of 8 weeks.

Protocol document: