Conditions: Parkinson's Disease Levodopa
Keywords: Parkinson's Disease Levodopa motor fluctuations gastroparesis
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 18
Healthy volunteers: no

Brief summary:
Gastroparesis (slow stomach emptying) is a common feature of Parkinson's Disease. Levodopa (Sinemet), a common medication for Parkinson's Disease, can make gastroparesis worse. Gastroparesis effects how the levodopa is absorbed and used by the body. This study will explore the possibility of using Erythromycin, a drug commonly used (off label) for gastroparesis, along with levodopa to determine if there is improved levodopa absorption and motor function.

Detailed description:
Participants will be required to make four visits for evaluation. Visit 1 is a screening visit, participants will receive the study drug or a placebo during visits 2 and 3, and visit 4 is a follow up visit. Participants will provide blood and urine samples during the visits. Participants will also be required to complete questionnaires and a series of motor tests.

Arms:
arm 1: One time IV dose of placebo arm 2: One time IV dose of 100 mg Erythromycin

Interventions: intervention 1: Erythromycin intervention 2: placebo
Intervention descriptions: intervention 1: None intervention 2: None

Protocol document: