Conditions: Mountain Sickness
Keywords: Altitude Sickness High Altitude Sickness
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 16
Healthy volunteers: yes

Brief summary:
This safety study is the first in a series of studies testing the application of the combination of aminophylline and methazolamide.

Detailed description:
After successful completion of this safety trial, our goal will be to evaluate the safety of this combination in healthy individuals exposed to hypoxia and exercise. Subsequently, an efficacy study will clarify whether this drug combination improves physical and mental functions in human subjects under high altitude conditions.

Arms:
arm 1: Aminophylline, Methazolamide, Aminophylline and Methazolamide arm 2: Methazolamide, Aminophylline, Aminophylline and Mathazolamide

Interventions: intervention 1: Aminophylline intervention 2: Methazolamide intervention 3: Aminophylline and Methazolamide
Intervention descriptions: intervention 1: Aminophylline dosage form-tablet dosage-500mg intervention 2: Methazolamide dosage form-tablet dosage-250mg intervention 3: Aminophylline 500mg orally and Methazolamide 250mg orally

Protocol document: