Conditions: Recurrent and/or Metastatic Head and Neck Cancer
Keywords: Squamous Cell Carcinoma Epidermal Growth Factor Epidermal Growth Factor Receptor SCCHN Metastatic Head and Neck Cancer EGFr Head and Neck Cancer Recurrent Head and Neck Cancer
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 658
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine the treatment effect of Panitumumab in combination with chemotherapy versus chemotherapy alone as first line therapy for metastatic and/or recurrent squamous cell carcinoma of the head and neck.

Detailed description:

Arms:
arm 1: Arm 2 consists of Cisplatin and 5-FU arm 2: ARM 1 Consists of Panitumumab plus Cisplatin and 5-FU

Interventions: intervention 1: ARM 2 intervention 2: ARM 1
Intervention descriptions: intervention 1: Subjects will receive Cisplatin plus 5FU intervention 2: Subjects will receive Panitumumab plus cisplatin and 5FU

Protocol document: