Conditions: Mild to Moderate Hypertension
Keywords: LCZ696, sildenafil, pharmacokinetics, mild to moderate hypertension
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 28
Healthy volunteers: no

Brief summary:
This study was conducted to investigate the potential for a pharmacokinetic drug-drug interaction in support of the co-administration of LCZ696 and sildenafil.

Detailed description:
This study was conducted to investigate the potential for a pharmacokinetic drug-drug interaction in patients with mild-to-moderate hypertension in support of the co-administration of LCZ696 and sildenafil.

Arms:
arm 1: During Treatment Period 1, on study Day 1, participants received a single dose of sildenafil followed by wash out on Day 2. In Period 2 (study Days 3-7), participants received LCZ696 once daily. In Period 3, on study Day 8, participants received LCZ696 , co-administered at the same time with a single dose of sildenafil.

Interventions: intervention 1: LCZ696 intervention 2: Sildenafil
Intervention descriptions: intervention 1: LCZ696 400mg QD was administered alone for 4 days and in combination with sildenafil for 1 day intervention 2: Sildenafil 50 mg single dose was administered alone for 1 days and in combination with LCZ696 400mg QD for 1 day

Protocol document: