Conditions: Mild to Moderately Active Ulcerative Colitis
Keywords: Ulcerative colitis EGCG Green tea polyphenols Inflammatory bowel disease Colitis IBD Green tea
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 20
Healthy volunteers: no

Brief summary:
Green tea consists of several components, with most research focusing on the polyphenol fraction. The polyphenol fraction(-)-epigallocatechin-3-gallate (EGCG)has been studied extensively as an anti-inflammatory agent as well as a preventative agent for cancer. It has been shown to effectively reduce the inflammation associated with animal models of inflammatory bowel disease. This clinical trial will determine the ability of EGCG, in the form of Polyphenon E®, to treat patients with mild to moderately severe ulcerative colitis.

Detailed description:

Arms:
arm 1: Polyphenon E® therapy was given for 56 days. arm 2: Oral Placebo

Interventions: intervention 1: Polyphenon E® intervention 2: Placebo Oral Tablet
Intervention descriptions: intervention 1: Oral capsules intervention 2: Oral tablet: placebo

Protocol document: