Conditions: Healthy
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 44
Healthy volunteers: yes

Brief summary:
The purpose of this study is to determine whether DAV132 is safe and effective for capturing fecal residues of moxifloxacin in healthy volunteers.

Detailed description:
The proposed study, DAV132-CL-1002, is to evaluate performances of DAV132 in healthy volunteers:

* To capture residual concentration of antibiotics in colon without interfering with their systemic pharmacokinetics parameters.
* To explore the influence of DAV132 to prevent the modification of gut flora due to antibiotic.

In addition, the security and acceptability of DAV132 used during 7 days will be evaluated.

The proposed study is prospective, randomized, controlled, four parallel groups, repeated doses, open-label study blinded to analytical and microbiological evaluations.

Arms:
arm 1: Moxifloxacin, oral tablets, 400mg/day, once daily 5 days arm 2: Moxifloxacin : 400mg/day for 5 days DAV132: 7.5g x3/day for 7 days arm 3: DAV132 oral, 7.5g x3/day for 7 days arm 4: Negative control: 7.5g x3/day for 7 days

Interventions: intervention 1: DAV132 intervention 2: Moxifloxacin intervention 3: Negative Control
Intervention descriptions: intervention 1: DAV132 is associated to moxifloxacin or it is evaluated alone intervention 2: Moxifloxacin is used alone or associated to DAV132 intervention 3: Moxifloxacin is used alone

Protocol document: