Conditions: Type 1 Diabetes Mellitus Type 2 Diabetes Mellitus Moderate Chronic Obstructive Pulmonary Disease Asthma
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 34
Healthy volunteers: no

Brief summary:
Examine the effects of TI in combination with an anti-diabetic regimen including inhaled insulin versus anti-diabetic treatment without inhaled insulin on lung function \& pulmonary safety

Detailed description:

Arms:
arm 1: Technosphere® Insulin Inhalation Powder administered prandially in diabetic participants with Asthma arm 2: Usual anti diabetic care in Diabetic participants with Asthma arm 3: Technosphere® Insulin Inhalation Powder administered prandially in diabetic participants with Chronic Obstructive Pulmonary disease (COPD) arm 4: Usual anti diabetic care in Diabetic participants with Chronic Obstructive Pulmonary disease (COPD)

Interventions: intervention 1: Technosphere® Insulin intervention 2: Usual Care
Intervention descriptions: intervention 1: Technosphere® Insulin delivered with Gen 2 inhaler with doses individualized for each participant in combination with an antidiabetic regimen of insulin and/or oral antidiabetic agents intervention 2: Type 1 diabetics: long-acting (basal) insulin plus rapid-acting insulin, or pre-mix insulin Type 2 diabetics: oral anti-diabetic medications with or without long-acting (basal) insulin

Protocol document: