Conditions: Healthy Volunteers
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 18
Healthy volunteers: yes

Brief summary:
The purposes of this study are to assess how the body handles baricitinib when it is given with another drug called probenecid. The study doctor will measure the amount of baricitinib that is absorbed into the blood stream and the time that it takes to remove baricitinib from the body. The safety and tolerability of these drugs will be studied. The study will last about 18 days from the first dose to the end of the study (not including screening).

Detailed description:

Arms:
arm 1: Single oral dose of 4 milligrams (mg) baricitinib on Day 1 arm 2: Oral doses of 1000 mg probenecid once daily on Days 3 through 7, with a single oral dose of 4 mg baricitinib co-administered on Day 5

Interventions: intervention 1: Baricitinib intervention 2: Probenecid
Intervention descriptions: intervention 1: Administered orally intervention 2: Administered orally

Protocol document: