Conditions: Knee Osteoarthritis
Keywords: knee osteoarthritis, native collagen type 2, paracetamol
Allocation: RANDOMIZED | Intervention model: FACTORIAL
Enrollment: 39
Healthy volunteers: no

Brief summary:
The aim of this study was to evaluate symptomatic efficacy of native collagen type 2 on joint pain and function and its effects on urinary biological markers related to cartilage degeneration in patients with knee osteoarthritis.

Detailed description:
39 patients diagnosed with knee osteoarthritis were separated into two groups. The 1st group includes 19 patients given 1500mg/day paracetamol, the 2nd group consists of 20 patients given 1500mg/day paracetamol and 10mg/day native collagen type 2 for three months.Pretreatment and posttreatment Visual Analog Scale, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), 20-m walking time and Short Form-36 (SF-36), Coll2-1, Coll2-1NO2 and Fibulin-3 levels in urine were compared.

Arms:
arm 1: The 1st group includes 19 patients given 1500mg/day paracetamol for three months arm 2: The 2nd group consists of 20 patients given 1500mg/day paracetamol and 10mg/day native collagen type 2 for three months

Interventions: intervention 1: paracetamol intervention 2: paracetamol+native collagen type 2
Intervention descriptions: intervention 1: 1500 mg intervention 2: paracetamol (1500 mg) + native collagen type 2 (10mg)

Protocol document: