Conditions: Breast Cancer
Keywords: Hormone receptor positive breast cancer first relapse
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 514
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine the efficacy of anastrozole monotherapy versus maximal oestrogen blockade with combinated therapy of fulvestrant and anastrozole compared with in treatment of hormone receptor positive women with first relapse of breast cancer.

Detailed description:

Arms:
arm 1: Anastrozole arm 2: Anastrozole + Fulvestrant

Interventions: intervention 1: Fulvestrant intervention 2: Anastrozole
Intervention descriptions: intervention 1: intramuscular injection 250 mg loading dose (LD) regimen intervention 2: 1 mg oral tablet

Protocol document: