Conditions: Thrombosis
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 151
Healthy volunteers: no

Brief summary:
This protocol will serve as a pilot study to determine the validity and feasibility of contrast enhanced magnetic resonance imaging (MRI) without and with contrast and/or ultrasound (US) for detection of catheter related deep vein thrombosis (DVT) in children

Detailed description:

Arms:
arm 1: Subjects with a central venous catheter (CVC) in place and asymptomatic for a CVC-related DVT to have an Ultrasound (US), Magnetic Resonance Imaging (MRI) with contrast and MRI without contrast performed. arm 2: Subjects with a CVC in place either symptomatic for a CVC-related DVT or having an incidental diagnosis of CVC-related DVT by radiographic imaging performed for other clinical reasons to have an Ultrasound, Magnetic Resonance Imaging (MRI) with contrast and MRI without contrast performed. arm 3: Subjects with a CVC in place having an MRI for clinical reasons to have an Ultrasound, Magnetic Resonance Imaging (MRI) with contrast and MRI without contrast performed.

Interventions: intervention 1: Ultrasound intervention 2: Magnetic Resonance Imaging with Contrast intervention 3: Magnetic Resonance Imaging without Contrast
Intervention descriptions: intervention 1: Ultrasounds to be performed on children with central venous catheters intervention 2: Contrast-enhanced Magnetic Resonance Imaging (MRI) to be performed on children with central venous catheters intervention 3: Magnetic Resonance Imaging (MRI) to be performed on children with central venous catheters

Protocol document: