Conditions: Glabellar Frown Lines
Keywords: Glabellar Frown Lines Frown Lines Facial Wrinkles
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 250
Healthy volunteers: no

Brief summary:
The purpose of this study is to show that two FDA-approved botulinum toxin drugs called Xeomin® and Botox® can reduce the severity of vertical lines (wrinkles) that appear between the eyebrows (glabellar frown lines).

Detailed description:
This is a prospective, multicenter, randomized, double-blind, parallel group clinical study to investigate the equivalence of incobotulinumtoxinA (Xeomin®) to onabotulinumtoxinA (Botox®) in the treatment of glabellar frown lines.

Arms:
arm 1: 20U injection: equal aliquots of 0.1 mL (4U) to 5 injection points arm 2: 20U injection: equal aliquots of 0.1 mL (4U) to 5 injection points

Interventions: intervention 1: IncobotulinumtoxinA intervention 2: OnabotulinumtoxinA
Intervention descriptions: intervention 1: 20U injection: equal aliquots of 0.1 mL (4U) to 5 injection points; mode of application: intramuscular injection intervention 2: 20U injection: equal aliquots of 0.1 mL (4U) to 5 injection points; mode of application: intramuscular injection

Protocol document: