Conditions: Open Angle Glaucoma Ocular Hypertension
Keywords: Primary open angle glaucoma or ocular hypertension
Allocation:  | Intervention model: PARALLEL
Enrollment: 166

Brief summary:
DE-111 ophthalmic solution will be evaluated for superiority in comparison with Timolol ophthalmic solution 0.5%, in IOP(intraocular pressure ) -lowering effect in primary open-angle glaucoma or ocular hypertension patients, in a multicenter, randomized, double-masked, parallel-group comparison study. Safety will be compared and evaluated as well.

Detailed description:

Arms:
arm 1: DE-111 ophthalmic solution (one drop at a time, once daily) and Placebo ophthalmic solution (one drop at a time, BID) in both eyes. arm 2: Timolol ophthalmic solution 0.5% (one drop at a time, BID) and Placebo ophthalmic solution (one drop at a time, once daily) in both eyes.

Interventions: intervention 1: DE-111 ophthalmic solution intervention 2: Timolol ophthalmic solution 0.5% intervention 3: Placebo ophthalmic solution
Intervention descriptions: intervention 1: None intervention 2: None intervention 3: None

Protocol document: