Conditions: Obesity Metabolic Syndrome Hyperuricemia
Keywords: Obesity Metabolic syndrome Hyperuricemia
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 31
Healthy volunteers: no

Brief summary:
The purpose of this study is to learn more about what is the effect of uric acid on oxidative stress and on the way the body metabolizes sugar in obese people. Understanding this may lead to better diseases such as diabetes.

Detailed description:
It has been hypothesized that oxidative stress is involved in the pathogenesis of insulin resistance associated with obesity. Circulating uric acid (UA) is the body's major endogenous plasma antioxidant. Therefore, the investigators evaluated whether alterations in serum UA concentration affect: 1) systemic and skeletal muscle oxidative stress, 2) total antioxidant capacity, and 4) skeletal muscle insulin sensitivity during a hyperinsulinemic-euglycemic clamp.

Arms:
arm 1: Subjects with a body mass index = or \> 30 kg/m² with normal uric acid (= or \< 5 mg/dL) arm 2: Subjects with a body mass index = or \> 30 kg/m² with high uric acid (\>6 mg/dL)

Intervention: one single infusion of rasburicase (0.19 mg/kg FFM) infused over 30 min

Interventions: intervention 1: Rasburicase
Intervention descriptions: intervention 1: one single infusion of rasburicase (0.19 mg/kg FFM) infused over 30 min

Protocol document: