Conditions: Hypercholesterolemia
Keywords: LDL, HDL
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 134
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine if Pitavastatin lowers CoQ10 less than Atorvastatin or Rosuvastatin.

Detailed description:
Statins are known effectively treat high cholesterol and heart disease. However, statins may lower endogenous levels of Coenzyme10 (CoQ10). This decrease in CoQ10 levels may be responsible for side effects such as myalgia.

Previous studies have shown that Pitavastatin may not affect CoQ10 levels as other statins do, while still lowering cholesterol.

In this study, investigators intend to compare the plasma levels of CoQ10 in patients taking 3 different FDA-approved statins, in equipotent doses.

Arms:
arm 1: Pitavastatin 4mg tablet by mouth once daily for 12 weeks arm 2: Atorvastatin 20mg tablet by mouth once daily for 12 weeks arm 3: rosuvastatin 5 mg tablet by mouth once daily for 12 weeks

Interventions: intervention 1: Pitavastin 4mg intervention 2: Atorvastatin 20mg intervention 3: Rosuvastatin 5mg
Intervention descriptions: intervention 1: None intervention 2: None intervention 3: None

Protocol document: