Conditions: Major Depressive Disorder
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 924
Healthy volunteers: no

Brief summary:
A multicenter, 8-week study to evaluate the efficacy of 2 doses (50 and 100 mg/day) of desvenlafaxine succinate sustained-release (DVS SR) versus placebo in adult outpatients with major depressive disorder.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None

Interventions: intervention 1: desvenlafaxine succinate sustained-release 50 mg/day intervention 2: desvenlafaxine succinate sustained-release 100 mg/day intervention 3: placebo
Intervention descriptions: intervention 1: 50 mg tablets of DVS SR taken orally once daily for 8 weeks; 1 week of placebo taper intervention 2: 100 mg tablets of DVS SR taken orally once daily for 8 weeks (which includes 1 week of titration at 50 mg/day); 1 week of taper at 50 mg/day intervention 3: 50 mg and 100 mg placebo matching tablets taken orally once daily for 8 weeks; 1 week of placebo taper

Protocol document: