Conditions: Allergic Rhinitis
Keywords: AZD8848 allergic rhinitis efficacy tolerability safety nasal symptoms
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 93
Healthy volunteers: no

Brief summary:
The primary purpose of this study is to investigate effect, tolerability and safety of different dosing regimens of AZD8848 administered intranasally to seasonal allergic rhinitis patients out of season in an allergen challenge model.

Detailed description:
A double-blind, placebo controlled, randomised, parallel group phase IIa study to investigate the efficacy, tolerability, and safety of different dosing regimens of AZD8848 administered intranasally to seasonal allergic rhinitis patients out of pollen season in a nasal allergen challenge model

Arms:
arm 1: 20 μg AZD8848 three times weekly arm 2: Placebo three times weekly arm 3: 60 μg AZD8848 once weekly and placebo twice weekly

Interventions: intervention 1: AZD8848 intervention 2: Placebo intervention 3: AZD8848 and placebo
Intervention descriptions: intervention 1: Nasal spray solution, intranasal, three times weekly for one month intervention 2: Nasal spray solution, intranasal, three times weekly for one month intervention 3: Nasal spray solution, intranasal, three times weekly for one month

Protocol document: