Conditions: Coagulopathy Nosocomial Pneumonia
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 11
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine the effect of antioxidant vitamins (vitamins C and E) on the development of coagulation derangements and nosocomial pneumonia after severe trauma in patients.

Detailed description:

Arms:
arm 1: Vitamin C (1,000 mg i.v.) and Vitamin E (1,000 IU p.o. via the naso-gastric tube) administered every 8 hours starting within one hour after admission to the Emergency department for up to 5 days or until discharge from the ICU, whichever comes first. arm 2: 100 ml of 0.9% saline (for i.v. Vitamin C) and a p.o. placebo (sugar pill for the p.o. Vitamin E) administered every 8 hours starting within one hour after admission to the Emergency department for up to 5 days or until discharge from the ICU, whichever comes first.

Interventions: intervention 1: Vitamin C intervention 2: Vitamin E intervention 3: Saline (for Vitamin C) intervention 4: Placebo (for Vitamin E)
Intervention descriptions: intervention 1: None intervention 2: None intervention 3: 0.9% saline administered to mimic Vitamin C intervention 4: Sugar pill administered to mimic Vitamin E

Protocol document: