Conditions: Healthy
Keywords: Herpes volunteers drug-drug interaction
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 24
Healthy volunteers: yes

Brief summary:
CYP2B6 is involved in the metabolism of many drugs. So, it is important to assess in vivo the effect of ASP2151 on that enzyme to determine any possible drug interactions. The aim of this trial is to investigate the potential for interaction of ASP2151 with the CYP2B6 probe substrate bupropion.

Detailed description:

Arms:
arm 1: 400 mg ASP2151 followed by 150 mg Bupropion

Interventions: intervention 1: Bupropion intervention 2: ASP2151
Intervention descriptions: intervention 1: None intervention 2: None

Protocol document: