Conditions: Autistic Disorder Asperger's Disorder Pervasive Developmental Disorder NOS
Keywords: Autism Spectrum Disorder D-cycloserine Social Skills Training
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 68
Healthy volunteers: yes

Brief summary:
The purpose of this study is to determine the effectiveness of D-cycloserine for improving social impairment in child with pervasive developmental disorders (PDD).

Detailed description:
This study will evaluate the efficacy of D-Cycloserine given 30 minutes prior to each of 10 weekly Social Skills Training Sessions for the treatment of social impairment in children (ages 5-11 years) with PDD during a randomized placebo-controlled trial. This will examine our central hypothesis that D-cycloserine will enhance learning of social skills in children with PDD's.

Arms:
arm 1: Subjects randomized to D-cycloserine will be administered 50 mg 30 minutes prior to each of ten Social Skills Training Sessions arm 2: Subjects randomized to placebo arm will receive placebo pill 30 minutes prior to each of ten Social Skills Training Sessions

Interventions: intervention 1: D-cycloserine intervention 2: Placebo
Intervention descriptions: intervention 1: 50 mg dose administered 30 minutes prior to each of the ten Social Skill Training Sessions intervention 2: Placebo pill administered 30 minutes prior to each of the ten Social Skill Training Sessions

Protocol document: