Conditions: Ovarian Cancer
Keywords: Ovarian Cancer Epithelial Ovarian Cancer Lovastatin Paclitaxel
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 11
Healthy volunteers: no

Brief summary:
The purpose of this study is to find out if the treatment combination of paclitaxel and lovastatin is more effective than the currently available chemotherapy for refractory or relapsed ovarian cancer. This research is being done to improve on currently available chemotherapy for ovarian cancer.

Detailed description:
The main goal of the study is to find out if adding lovastatin to paclitaxel increases the number of people whose tumors shrink or whose disease responds to the treatment. Another purpose of the study is to find out how long tumors stay reduced in size before growing again as well as how long people live after receiving paclitaxel and lovastatin. The study will also gather information on the side effects, if any, of this combination of paclitaxel and lovastatin.

Arms:
arm 1: Paclitaxel given at 80 mg/m2 IV over 1 hour on day 1 and repeated weekly. Lovastatin self-administered at 80mg daily.

Interventions: intervention 1: Paclitaxel intervention 2: Lovastatin
Intervention descriptions: intervention 1: Paclitaxel will be given at 80 mg/m2 IV over 1 hour on day 1 and repeated weekly intervention 2: Lovastatin, 80 mg, po, daily will be self-administered by the subject.

Protocol document: