Conditions: Healthy Participants
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 16
Healthy volunteers: yes

Brief summary:
This open-label, 2-period, fixed sequence, drug interaction study will investigate the effect of co-administration of itraconazole on the pharmacokinetics of cobimetinib in healthy participants. Participants will receive multiple repeating doses of cobimetinib and itraconazole.

Detailed description:

Arms:
arm 1: None

Interventions: intervention 1: Cobimetinib intervention 2: Itraconazole
Intervention descriptions: intervention 1: 10 milligram (mg) (2\* 5 mg capsules) will be administered orally on Day 1 of Period 1 and Day 4 of Period 2 intervention 2: 200 mg oral solution will be administered once daily from Day 1 to Day 14 of Period 2

Protocol document: