Conditions: Upper Respiratory Tract Infections
Keywords: Days with URTI symptoms
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 40
Healthy volunteers: yes

Brief summary:
To investigate if use of glucosoxidas nasal spray can reduce the number of days with upper respiratory tract infections in children beyond 4 years.

Detailed description:
Children below 4 years of age and in public day care were invited to participate in this prospective study. The children started with a visit to an ENT doctor and after inclusion the children started to spray twice daily with glucose oxidase+glucose or only saline+glucose for 3 months. During this period the parents were asked to fill in a home protocol recording upper respiratory tract symptoms as: rhinitis, cough, fever, ear ache. After 6 weeks and 12 weeks the children had scheduled visits to the ENT department, where an ENT doctor examined the throat, nasal cavity and the ear drums for otitis media. After 12 weeks of treatment a nasopharyngeal swab was taken for bacterial culture.

Arms:
arm 1: Subjects received nasal spray containing both saline+glucose twice daily for 3 months arm 2: Nasal spray in a bag-on-valve device with 50U/ml containing both glucose oxidase + 5% glucose in isotone saline. Dosage: One puff in each nostril twice daily for 3 months.

Interventions: intervention 1: Placebo intervention 2: Glucose oxidase
Intervention descriptions: intervention 1: placebo containing saline+glucose intervention 2: a hydrogen peroxide producing enzyme that creates an acidous environment to which rhinoviruses are sensitive.

Protocol document: