Conditions: Pain
Keywords: Males or females 18 years of age or older. Non-emergency cardiac surgery midline sternotomy.
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 150
Healthy volunteers: no

Brief summary:
Evaluate the efficacy of IV acetaminophen; compared to a placebo, in reducing opioid consumption and/or pain intensity scores after cardiac surgery.

Detailed description:

Arms:
arm 1: Patients will receive up to four doses of IV Acetaminophen (1000mg)every six hours after surgery along with standard PCA (patient controlled) opioids. arm 2: Patients will receive up to four doses of IV placebo every six hours after surgery along with standard PCA (patient controlled) opioids.

Interventions: intervention 1: IV Acetaminophen intervention 2: Placebo
Intervention descriptions: intervention 1: Patients will receive up to four doses of IV Acetaminophen (1000mg)every six hours after surgery along with standard PCA (patient controlled) opioids. intervention 2: Patients will receive up to four doses placebo every six hours after surgery along with standard PCA (patient controlled) opioids.

Protocol document: