Conditions: Migraine
Keywords: Migraine disorders Headache Simvastatin Vitamin D
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 89
Healthy volunteers: no

Brief summary:
The investigators are studying if taking simvastatin and vitamin D together will help prevent episodic migraines. Simvastatin is an FDA approved drug that is typically used to treat high cholesterol and reduce the risk of stroke and heart attack. Vitamin D is a vitamin found in certain foods like some types of fish, and in nutritional supplements. This study is 9 months long. Some people who participate will receive simvastatin and vitamin D, and some people will receive a placebo. A placebo is a "sugar pill" that looks like medication but does not have any active ingredients in it.

The investigators hypothesize that taking vitamin D and simvastatin daily may reduce the number of migraines people who have episodic migraine get.

Detailed description:

Arms:
arm 1: Participants in this arm will receive simvastatin + vitamin D. arm 2: Participants in this arm will take placebo pills, which look like the simvastatin and vitamin D. A placebo pill has no active medication in it, and is like taking a "sugar pill".

Interventions: intervention 1: Simvastatin intervention 2: Vitamin D intervention 3: Placebo
Intervention descriptions: intervention 1: simvastatin, 20 mg, twice daily for 6 months intervention 2: Vitamin D3, 1000 IU, twice daily for 6 months intervention 3: Two placebo pills, taken twice daily for 6 months

Protocol document: