Conditions: Epilepsy
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 207
Healthy volunteers: no

Brief summary:
To evaluate the efficacy of usual monotherapy and low dose combination of Lamotrigine and Valproate. Low dose combination may be more effective and tolerable because they are low dose and VPA reduce Lamotrigine metabolism.

Detailed description:
An Open label, Randomized, Multicenter Clinical Trial to Compare the Efficacy and Safety of Lamotrigine / Valproate Coadministration and Carbamazepine as Initial Pharmacotherapy in Epilepsies

Arms:
arm 1: Carbamazepine arm 2: Lamotrigine and Valproate combination therapy

Interventions: intervention 1: Carbamazepine intervention 2: Lamotrigine/Valproate
Intervention descriptions: intervention 1: None intervention 2: None

Protocol document: