Conditions: Obstructive Sleep Apnea
Keywords: OSA Medical treatment
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 34
Healthy volunteers: no

Brief summary:
In children with mild apnea combined therapy with an inhaled nasal steroid and a medication that decreased nasal congestion (montelukast) was shown to be effective. We are testing to see if this combination works in adults with mild apnea as well.

Detailed description:
40 adults with mild OSA (\< 5 apneas/hypopneas per hour of sleep) will receive either a combination of two medicines that decrease nasal congestion-montelukast and nasal budesonide-or a placebo pill and nasal spray. After 3 months of therapy, a repeat sleep study will be done to determine the differences, if any, in the frequency of sleep disordered breathing in the two groups.

Arms:
arm 1: treatment arm arm 2: sugar pill, salt water nasal spray

Interventions: intervention 1: budesonide and montelukast intervention 2: Placebo
Intervention descriptions: intervention 1: budesonide aqua nasal spray 1 spray each nostril bid for 12 weeks Montelukast pill 10 mg po daily for 12 weeks intervention 2: sugar pill po daily for 12 weeks salt water nasal spray 1 spray each nostril bid for 12 weeks

Protocol document: