Conditions: Constipation-predominant Irritable Bowel Syndrome
Keywords: Constipation predominant Irritable Bowel Syndrome
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 37
Healthy volunteers: no

Brief summary:
In this study the investigators aim to compare the efficacy of neomycin to a combination of rifaximin and neomycin in the treatment of C-IBS subjects with methane on their breath test. This study will be conducted in collaboration with Dr. John DiBaise at the Mayo Clinic in Scottsdale, AZ and Dr. Satish Rao in Georgia Regents University in Augusta, GA.

Detailed description:

Arms:
arm 1: Group 1 will receive neomycin (500 mg po bid) and placebo (tid) for 14 days arm 2: Group 2 will receive neomycin (500 mg po bid) and rifaximin (550mg po tid) for 14 days

Interventions: intervention 1: Neomycin intervention 2: Placebo intervention 3: Rifaximin
Intervention descriptions: intervention 1: 500 mg po bid for 14 days intervention 2: placebo for 14 days tid intervention 3: 550 mg po tid

Protocol document: