Conditions: Waldenstrom's Macroglobulinemia Multiple Myeloma
Keywords: Waldenstrom's Macroglobulinemia Multiple Myeloma
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 56
Healthy volunteers: no

Brief summary:
To determine whether further study of single-agent enzastaurin is warranted in patients with previously treated Waldenstrom's Macroglobulinemia or Multiple Myeloma based on response.

Detailed description:

Arms:
arm 1: None

Interventions: intervention 1: Enzastaurin
Intervention descriptions: intervention 1: Enzastaurin: Cycle 1 Day 1 only: 3, 125-milligrams (mg) tablets three times on Day 1 (Day 1 total dose = 1125 mg)

Day 2 onwards and subsequent Cycles: 2, 125-mg tablets orally twice a day (500 mg total per day).

Cycle length (all cycles): 28 days. Patients may stay on drug past 8 cycles, (until the study is closed) or until disease progression.

Protocol document: