Conditions: Postpartum Hemorrhage
Keywords: Postpartum hemorrhage Intrapartum blood loss Misoprostol
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 636
Healthy volunteers: yes

Brief summary:
The aim of the work is to evaluate \& compare the effectiveness of rectally administered PGE1 synthetic analogue (misoprostol) 400 microgram versus sublingually administered misoprostol before caesarean section to decrease blood loss during and after the operation.

Detailed description:

Arms:
arm 1: will receive 400 microgram of misoprostol (Sigma) sublingual "2 tablets" and rectal placebo"2 tablets". arm 2: will receive rectal placebo"2 tablets" and sublingual placebo"2 tablets". arm 3: will receive 400 microgram of misoprostol (Sigma) rectal "2 tablets" and sublingual placebo"2 tablets".

Interventions: intervention 1: Misoprostol intervention 2: Placebo
Intervention descriptions: intervention 1: Comparison of different routes of administration of 400 micro gram misoprostol intervention 2: None

Protocol document: