Conditions: Treatment Resistant Major Depressive Disorder
Keywords: Patients
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 22
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine the antidepressant effects of AZD6765 compared to placebo.

Detailed description:

Arms:
arm 1: Patients randomized to receive a single intravenous (iv) infusion of AZD6765 (150 mg) over 60 minutes during the first period, followed by a 7-day drug-free period, followed by a single iv infusion of placebo (saline solution) over 60 minutes during the second period. arm 2: Patients randomized to receive a single intravenous (iv) infusion of placebo (saline solution) over 60 minutes during the first period, followed by a 7-day drug-free period, followed by a single iv infusion of AZD6765 (150 mg) over 60 minutes during the second period.

Interventions: intervention 1: AZD6765 intervention 2: Placebo to AZD6765
Intervention descriptions: intervention 1: Single IV infusion of 150 mg AZD6765. intervention 2: Single IV infusion of Placebo to AZD6765

Protocol document: