Conditions: Postoperative Dental Pain
Keywords: Postoperative dental pain
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 235
Healthy volunteers: no

Brief summary:
The objective of this study is to evaluate the overall pain relief of a single dose of PF-05089771 against placebo following third molar extraction.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None arm 4: None arm 5: None

Interventions: intervention 1: PF-05089771 intervention 2: Placebo intervention 3: PF-05089771 intervention 4: Placebo intervention 5: PF-05089771 intervention 6: Placebo intervention 7: Ibuprofen intervention 8: Placebo intervention 9: Placebo intervention 10: Placebo
Intervention descriptions: intervention 1: A single dose of PF-05089771 1600 mg oral solution administered once to the subject on Day 1 postoperatively intervention 2: Placebo tablets for ibuprofen: 2 X 200 mg placebo tablets administered orally once to the subject on Day 1 postoperatively intervention 3: A single dose of PF-05089771 450 mg oral solution administered once to the subject on Day 1 postoperatively intervention 4: Placebo tablets for ibuprofen: 2 X 200 mg placebo tablets administered orally once to the subject on Day 1 postoperatively intervention 5: A single dose of PF-05089771 150 mg oral solution administered once to the subject on Day 1 postoperatively intervention 6: Placebo tablets for ibuprofen: 2 X 200 mg placebo tablets administered orally once to the subject on Day 1 postoperatively intervention 7: 2 X 200 mg tablets of ibuprofen administered orally once to the subject on Day 1 postoperatively intervention 8: Placebo solution for PF-05089771: A single dose of Placebo solution administered once to the subject on Day 1 postoperatively intervention 9: Placebo solution for PF-05089771:A single dose of Placebo solution administered once to the subject on Day 1 postoperatively intervention 10: Placebo tablets for Ibuprofen: 2 X 200 mg placebo tablets administered orally once to the subject on Day 1 postoperatively

Protocol document: