Conditions: Metabolic Syndrome
Keywords: Metabolic syndrome Diabetes mellitus, Hypertension Overweight analimentary detoxication
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 351
Healthy volunteers: yes

Brief summary:
Metabolic syndrome: aetiology, pathogenesis, diagnosis, clinical management and prognosis

Detailed description:
Purpose: To create the complex scientifically proved concept of Metabolic syndrome (МS) development based on elaboration of the new methods of clinical diagnostics of МS components and highly effective МS clinical management in comparative studying of clinical, laboratory and cost effectiveness.

Participants and methods: This clinical study included 351 adults (184 female) in the Scientific research institute of cardiology and internal diseases (Almaty, the Republic of Kazakhstan). Statistical analysis was performed using Microsoft Excel-2008 in updating Lapach, Chubenko et al (2000) and SPSS for Windows v.17.0.

Arms:
arm 1: Xenical, Pionorm, Diroton, Diltiazem, Atorvastatin arm 2: Vegetables and salt diet arm 3: 64 healthy people

Interventions: intervention 1: Xenical, Pionorm, Diroton, Diltiazem, Atorvastatin intervention 2: "Analimentary detoxication"
Intervention descriptions: intervention 1: Xenical (Orlistat) - 120 mg/day in integration of Pionorm (Pioglitazone hydrochlorid) - 30 mg/day, Diroton (Lizinopril) - 20 mg/day, Diltiazem - 90 mg/day, Atorvastatin (Liprimar) - 40 mg/day intervention 2: Vegetable and salt diet

Protocol document: