Conditions: Healthy
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 16
Healthy volunteers: yes

Brief summary:
The purpose of this trial is to investigate the effect of food with different fat content and of gastric pH increase (mediated by multiple dosing of omeprazole) on the relative bioavailability of deleobuvir.

Detailed description:

Arms:
arm 1: patient to receive BI 207127 as a single dose in fasted state arm 2: patient to receive BI 207127 as a single dose after a high fat breakfast arm 3: patient to receive BI 207127 as a single dose after a low fat breakfast arm 4: patient to receive BI 207127 as a single dose after 4 days treatment with Omeprazole 40 mg once a day

Interventions: intervention 1: BI 207127 high fat intervention 2: BI 207127 with Omeprazole intervention 3: BI 207127 intervention 4: BI 207127 low fat
Intervention descriptions: intervention 1: BI 207127 as a single dose after a high fat breakfast intervention 2: BI 207127 as a single dose after 4 days treatment of Omeprazole 40 mg once a day intervention 3: BI 207127 as a single dose in fasted state intervention 4: BI 207127 as a single dose after a low fat breakfast

Protocol document: