Conditions: Healthy
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 81
Healthy volunteers: yes

Brief summary:
To investigate safety, tolerability, pharmacokinetics (PK), and pharmacodynamics of single rising doses of BI 691751 in healthy male subjects (part I).

To investigate the relative bioavailability of BI 691751 given as tablet versus oral solution (part II)

Detailed description:

Arms:
arm 1: single dose given as oral solution arm 2: single dose given as oral solution arm 3: single dose given as oral solution arm 4: single dose given as oral solution arm 5: single dose given as oral solution arm 6: single dose given as oral solution arm 7: single dose given as oral solution arm 8: placebo solution arm 9: single dose given as 1 tablet arm 10: single dose given as oral solution

Interventions: intervention 1: BI 691751 intervention 2: BI 691751 intervention 3: Placebo intervention 4: BI 691751 intervention 5: BI 691751 intervention 6: BI 691751 intervention 7: BI 691751 intervention 8: BI 691751 intervention 9: BI 691751 intervention 10: BI 691751
Intervention descriptions: intervention 1: oral solution BI 691751, dose 6 intervention 2: oral solution intervention 3: placebo solution intervention 4: oral solution BI 691751, dose 2 intervention 5: oral solution BI 691751, dose 5 intervention 6: 1 tablet intervention 7: oral solution BI 691751, dose 3 intervention 8: oral solution BI 69175, dose 4 intervention 9: oral solution BI 691751, dose 7 intervention 10: oral solution BI 69175, dose 1

Protocol document: