Conditions: Open-Angle Glaucoma Ocular Hypertension
Keywords: Open-Angle Glaucoma Ocular Hypertension Simbrinza™ Intraocular Pressure
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 89
Healthy volunteers: no

Brief summary:
The purpose of this study is to evaluate intraocular pressure (IOP) over a 24-hour period using Simbrinza™ topical ophthalmic suspension.

Detailed description:
This study consisted of two phases, a Screening/Eligibility Phase and a Treatment Phase. Both phases required the patient to complete an overnight stay.

Arms:
arm 1: Brinzolamide 1%/Brimonidine 0.2% ophthalmic suspension, 1 drop 3 times a day (8AM, 3PM, 10PM) in each eye for 4 weeks arm 2: Timolol Maleate 0.5%, 1 drop twice a day (8AM, 8PM) in each eye for 4 weeks

Interventions: intervention 1: Brinzolamide 1%/Brimonidine 0.2% ophthalmic suspension intervention 2: Timolol Maleate 0.5%
Intervention descriptions: intervention 1: Commercially marketed and approved for lowering IOP in patients with open-angle glaucoma and ocular hypertension. intervention 2: Commercially marketed and approved for lowering IOP in patients with open-angle glaucoma and ocular hypertension.

Protocol document: