Conditions: Breast Cancer
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 23
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine if Indocyanine Green (IC-GREEN) is comparable to isosulfan blue (IS-BLUE) in the identification of arm lymphatics and arm-draining nodes during nodal staging procedures in breast cancer.

Detailed description:
It is the objective of the current study to test Indocyanine Green (IC-GREEN) as an agent for mapping arm draining lymphatics and nodes and compare it to isosulfan blue (IS-BLUE) in the setting of sentinel node procedures with or without axillary node dissections in women with breast cancer. All participants will also have tumor samples evaluated with 99technetium-sulfur colloid, a radiolabel used to identify tumor markers.

Arms:
arm 1: The dose of Isosulfan blue (ISB) dye and Indocyanine green (ICG) solution will be started.

(IC-GREEN) SPY Elite Imaging willbe used to capture the images of axillary cavity.

Interventions: intervention 1: SPY Elite Imaging intervention 2: Indocyanine Green intervention 3: Isosulfan blue intervention 4: 99technetium-sulfur colloid radiolabel
Intervention descriptions: intervention 1: A camera that is directed into the axillary cavity to try to capture an image of the tumor site labeled with Indocyanine green before and after excising sentinel nodes intervention 2: started at 1mg /mL

If fluorescence is not detected with this dose, then it will be increased by 50%. intervention 3: 3 to 5 mL

If fluorescence is not detected with this dose, then it will be increased by 50%. intervention 4: None

Protocol document: