Conditions: Healthy Volunteers
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 16
Healthy volunteers: yes

Brief summary:
The main purpose of this study is to determine how much digoxin gets into the blood stream and how long it takes the body to get rid of it when given with the study drug evacetrapib. This study will also look at the effect of evacetrapib on the removal of digoxin from the body by the kidneys. Information about any side effects that may occur will be collected. This study will last approximately 33 days for each participant, not including screening.

Detailed description:

Arms:
arm 1: 0.5 milligram (mg) digoxin administered orally once daily (QD) on Day 1 arm 2: 130 mg evacetrapib administered orally, QD for 14 days (Days 6 through 19) with a single oral dose of 0.5 mg digoxin coadministered on Day 15

Interventions: intervention 1: Evacetrapib intervention 2: Digoxin
Intervention descriptions: intervention 1: Administered orally intervention 2: Administered orally

Protocol document: