Conditions: Salt-sensitive Hypertension
Keywords: hypertension, salt sensitivity, valsartan, LCZ696
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 72
Healthy volunteers: no

Brief summary:
This study will evaluate the effect of LCZ696 and valsartan on natriuresis, diuresis, and blood pressure in salt-sensitive Asian hypertensive patients.

Detailed description:

Arms:
arm 1: Period 1: LCZ696 400mg QD for 4 weeks then washout followed by Period 2: Valsartan 320mg QD for 4 weeks arm 2: Period 1: Valsartan 320mg QD for 4 weeks then washout followed by Period 2: LCZ696 400mg QD for 4 weeks

Interventions: intervention 1: Valsartan intervention 2: LCZ696
Intervention descriptions: intervention 1: Valsartan 320mg tablet once daily intervention 2: LCZ696 400mg tablet once daily

Protocol document: