Conditions: Renal Transplant Rejection
Keywords: Kidney Transplantation Immunosuppression
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 15
Healthy volunteers: no

Brief summary:
This study aims to compare outcomes in renal transplant recipients in the hispanic population based on their immunosuppressant regimens.

Detailed description:
This study aims to include Hispanics who have undergone a renal transplant to determine the specific outcome after renal transplantation, assuming that ethnic groups require different immunosuppressant regimens. Trough levels in transplant recipients determine the dosing requirements for Tacrolimus and Cyclosproine. It has been recently found, however, that testing cyclosporine levels in the blood 2 hours after taking cyclosporine is more effective in dosing cyclosprine for renal transplant patients than trough levels. The specific study aims include comparing the cyclosporine monitoring in patients with trough and C2 levels, and adjusting immunosuppression based on C2 levels.

Arms:
arm 1: Neoral is a pill indicated for the prophylaxis of organ rejection in kidney transplants arm 2: Prograf is a medication used for the prophylaxis of rejection in allogeneic kidney transplants and may be used concomitantly with adrenal corticosteroids.

Interventions: intervention 1: Prograf intervention 2: Neoral
Intervention descriptions: intervention 1: Tacrolimus (Prograf) starting dose 0.05-0.15 mg/kg PO BID intervention 2: Cyclosporine (Neoral) starting dose 3mg/kg PO BID

Protocol document: