Conditions: Leukemia
Keywords: B-cell adult acute lymphoblastic leukemia T-cell adult acute lymphoblastic leukemia untreated adult acute lymphoblastic leukemia L1 adult acute lymphoblastic leukemia L2 adult acute lymphoblastic leukemia TdT positive adult acute lymphoblastic leukemia
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 470
Healthy volunteers: no

Brief summary:
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Imatinib mesylate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. A peripheral stem cell transplant may be able to replace blood-forming cells that were destroyed by chemotherapy. When the healthy stem cells are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Giving combination chemotherapy together with imatinib mesylate and peripheral stem cell transplant may be an effective treatment for acute lymphoblastic leukemia.

Nevertheless, in the last few years GIMEMA has pubblished a paper in which 100% of Ph+ ALL patients reach HCR only with Imatinib, without any chemiotherapy. Thus, this treatment will be implemented in patients pertaining to this category.

Detailed description:

Arms:

Interventions: intervention 1: asparaginase intervention 2: daunorubicin hydrochloride intervention 3: etoposide intervention 4: idarubicin intervention 5: imatinib mesylate intervention 6: mercaptopurine intervention 7: methotrexate intervention 8: methylprednisolone intervention 9: mitoxantrone hydrochloride intervention 10: prednisone intervention 11: vincristine sulfate intervention 12: allogeneic hematopoietic stem cell transplantation intervention 13: autologous hematopoietic stem cell transplantation intervention 14: peripheral blood stem cell transplantation intervention 15: radiation therapy
Intervention descriptions: intervention 1: None intervention 2: None intervention 3: None intervention 4: None intervention 5: None intervention 6: None intervention 7: None intervention 8: None intervention 9: None intervention 10: None intervention 11: None intervention 12: None intervention 13: None intervention 14: None intervention 15: None

Protocol document: