Conditions: Hypertension Concurrent Obesity
Keywords: Hypertension, obesity, insulin sensitivity, lipolysis, LCZ696
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 98
Healthy volunteers: no

Brief summary:
This study investigated the effects of LCZ696 on insulin sensitivity, lipolysis, and oxidative metabolism in obese hypertensive subjects.

Detailed description:

Arms:
arm 1: LCZ696 400 mg plus placebo to amlodipine once daily for 8 weeks arm 2: amlodipine 10 mg plus placebo to LCZ696 once daily for 8 weeks

Interventions: intervention 1: LCZ696 intervention 2: amlodipine intervention 3: Placebo
Intervention descriptions: intervention 1: LCZ696 was provided as 400 mg tablets. intervention 2: amlodipine was provided as 5 mg tablets. intervention 3: Matching placebo to LCZ696 and amlodipine.

Protocol document: