Conditions: Osteoporosis
Keywords: Osteoporosis Osteoporotic fractures Bisphosphonate Pretreatment with bisphosphonates
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 436
Healthy volunteers: no

Brief summary:
The purpose of this study is to evaluate the efficacy and safety of bisphosphonates in long term treatment of osteoporosis.

Detailed description:
Is a continued treatment with alendronate for another two years after a preceding therapy with bisphosphonates of at least four years able to reduce the incidence of new osteoporotic fractures in patients at high fracture risk compared to a therapy-free interval?

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Alendronate intervention 2: Placebo
Intervention descriptions: intervention 1: 70 mg per week intervention 2: 1 pill per week

Protocol document: