Conditions: Hypertension
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 70
Healthy volunteers: no

Brief summary:
This is an investigator initiated, sponsored, open label, prospective randomized controlled trial to be performed in adult patients undergoing scheduled cardiac surgery. Patients will be randomized to esmolol infusion or nitroglycerin infusion for control of hypertension that occurs during cardiac surgery from induction of anesthesia to initiation of cardiopulmonary bypass (CPB).

Detailed description:

Arms:
arm 1: nitroglycerin titrated to control hypertension between anesthesia induction and initiation of cardiopulmonary bypass arm 2: esmolol titrated to control hypertension between anesthesia induction and initiation of cardiopulmonary bypass

Interventions: intervention 1: nitroglycerin intervention 2: esmolol
Intervention descriptions: intervention 1: nitroglycerin administered as an infusion following a step up/step down protocol to treat hypertension in patients undergoing cardiac surgery. intervention 2: esmolol will be administered by infusion following a step up / step down protocol to control hypertension.

Protocol document: