Conditions: Pain
Keywords: Pain Propofol Dexmedetomidine Midazolam Effects of sedation on pain perception.
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 86
Healthy volunteers: yes

Brief summary:
The investigators propose to evaluate the potential effect of sedation on pain perception in two ways, by asking for a participant's pain rating(subjective) and by evaluating a subject's brain activation using fMRI(objective).

Detailed description:
We propose to contrast and compare the effect of propofol and midazolam, two GABA-related sedative drugs, and dexmedetomidine, an alpha-2 adrenergic agonist, on pain perception in human volunteers by asking a participant to rate their pain and by evaluating a subject's brain activation using fMRI.

Arms:
arm 1: Administration via an IV arm 2: Administration via an IV arm 3: Administration via an IV

Interventions: intervention 1: dexmedetomidine intervention 2: midazolam intervention 3: propofol
Intervention descriptions: intervention 1: None intervention 2: None intervention 3: None

Protocol document: