Conditions: Parkinson's Disease
Keywords: Freezing of gait gait dysfunction
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 3
Healthy volunteers: no

Brief summary:
The purpose of this study is to explore the efficacy of the drug Amantadine for the treatment of freezing of gait in patients with Parkinson's Disease. The investigators hypothesize that amantadine is useful for management of freezing of gait in subjects with Parkinson's Disease.

Detailed description:
Subjects who meet the eligibility requirements for the study will be randomized to Amantadine versus a matching placebo.

Arms:
arm 1: Amantadine 100mg daily, for a week, if it is tolerated Amantadine will increase to 1 tab twice a day arm 2: Sugar Pill

Interventions: intervention 1: Amantadine intervention 2: Placebo
Intervention descriptions: intervention 1: Amantadine 100mg daily, for a week, if it is tolerated Amantadine will increase to 1 tab twice a day. Amantadine will then be administered orally twice daily in the morning with breakfast and at noon with lunch (AM and NN). intervention 2: Sugar Pill

Protocol document: