Conditions: C.Surgical Procedure; Cardiac
Keywords: tranexamic acid cardiac surgery cardiopulmonary bypass
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 955
Healthy volunteers: no

Brief summary:
Tranexamic acid, an antifibrinolytic drug, is wildly used in cardiac surgeries to decrease perioperative bleeding and allogenic transfusion. But the optimum dose of tranexamic acid is still unknown. We use three different doses to find which is the optimum dose of tranexamic acid in cardiopulmonary bypass cardiac surgery.

Detailed description:

Arms:
arm 1: 10mg/kg tranexamic acid add in priming fluid, 10mg/kg single shot slowly when incision, followed by 2mg/(kg·h) infusion until the end of surgery arm 2: 20mg/kg tranexamic acid add in priming fluid, 20mg/kg single shot slowly when incision, followed by 4mg/(kg·h) infusion until the end of surgery arm 3: 30mg/kg tranexamic acid add in priming fluid, 30mg/kg single shot slowly when incision, followed by 6mg/(kg·h) infusion until the end of surgery

Interventions: intervention 1: Tranexamic Acid
Intervention descriptions: intervention 1: The loading doses were given in 15 minutes when incision.

Protocol document: