Conditions: Chronic Pain Post-operative Pain
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 131
Healthy volunteers: yes

Brief summary:
The investigators are looking at whether peri-operative minocycline will reduce the duration of pain after minor hand surgery: carpal tunnel release and trigger finger release.

The investigators' hypothesis is that minocycline will reduce post-operative pain.

Detailed description:
This is a double blinded randomized controlled trial. Patients are given 100mg of minocycline 2 hours prior to their procedure and then 100mg two times a day for 5 days. The subjects are then contacted daily to check their level of pain. The investigators' outcome of interest is time to pain resolution.

The investigators will perform a futility analysis to assess if a larger trial would be a reasonable next step after this pilot study.

Arms:
arm 1: perioperative minocycline for 5 days, starting 2 hours prior to surgery then 100mg BID arm 2: PLacebo

Interventions: intervention 1: Minocycline intervention 2: placebo
Intervention descriptions: intervention 1: RCT blinded placebo trial intervention 2: RCT blinded placebo trial

Protocol document: