Conditions: Primary Total Hip and Knee Arthroplasty
Keywords: Hip, Knee, Arthroplasty, venous thromboembolic events, blood loss
Allocation: RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 54
Healthy volunteers: no

Brief summary:
This is a prospective, randomized study from pre-surgery to 6 weeks post-surgery designed to detect changes in coagulability following elective total knee and hip arthroplasty. Patients will be randomized to one of the two standard prophylaxis treatments used at Sinai Hospital:

1. Arixtra (2.5 mg SQ/QD) subcutaneous injection daily for 2 weeks followed by aspirin 325 mg for 5 weeks, or
2. Pneumatic compression stockings (MCS, Active Care, medical compression systems Inc., Israel) for 2 weeks with concomitant Aspirin 325 mg daily for 5 weeks.

Detailed description:

Arms:
arm 1: Arixtra (2.5 mg SQ/QD) subcutaneous injection daily for 2 weeks followed by aspirin 325 mg for 5 weeks arm 2: Pneumatic compression stockings (MCS, Active Care, medical compression systems Inc., Israel) for 2 weeks with concomitant Aspirin 325 mg daily for 5 weeks.

Interventions: intervention 1: Arixtra intervention 2: Pneumatic compression stockings intervention 3: Aspirin
Intervention descriptions: intervention 1: None intervention 2: Pneumatic compression stockings (MCS, Active Care, medical compression systems Inc., Israel) intervention 3: None

Protocol document: