Conditions: Revision Total Hip Arthroplasty (RTHA)
Keywords: Autologous blood donation, allogeneic blood transfusion
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 60
Healthy volunteers: no

Brief summary:
Sixty patients aged between 60 and 75 years old of both sex of ASA physical status I and II were included in this randomized study who were divided into the study group of 30 patients who had been transfused autologous blood and the control group of 30 patients who had been transfused only allogeneic blood. Parenteral iron preparation was given to all patients of the study group after each donation. Intraoperatively all patients of the study group received 2 grams of intravenous tranexamic acid. This study was conducted through the laboratory analysis of the hemoglobin and the hematocrit values during blood donation and for both groups in the pre-operative and the post-operative period and the assessment of the amount of transfused blood units in both groups.

Detailed description:
A total of 60 patients were included in this randomized study that were divided into a study group of 30 patients, who had been transfused autologous blood and a control group of 30 patients who had been transfused only allogeneic blood. Parenteral iron preparation was given to all patients of the study group after each donation. Intraoperatively all patients of the study group received 2 g of intravenous TXA.

This study was conducted through laboratory analysis of hemoglobin and hematocrit values during blood donation and for both groups in the preoperative and the postoperative period and the assessment of the amount of transfused blood units in both groups.

Arms:
arm 1: The control group, which consisted of 30 patients who were transfused only allogeneic blood. arm 2: the study group including 30patients who were transfused pre-operatively donated autologous blood, either during surgery or after it.

Interventions: intervention 1: transfused pre-operatively donated autologous blood. intervention 2: intravenous tranexamic acid (TXA) infusion intervention 3: transfused only allogeneic blood.
Intervention descriptions: intervention 1: Pre-operative autologous donation for minimising perioperative allogeneic blood transfusion intervention 2: Intravenous tranexamic acid is a safe pharmacological treatment to reduce blood loss and transfusion requirements in patients undergoing major orthopedic surgery. intervention 3: None

Protocol document: