Conditions: Overactive Bladder
Keywords: Overactive bladder Solifenacin succinate Tamsulosin
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 70
Healthy volunteers: no

Brief summary:
The aim of the study is to investigate if the combination therapy consisting of anticholinergics plus alpha-blockers could be beneficial for women suffering from Overactive Bladder (OAB).

Detailed description:
Overactive bladder (OAB) describes the symptom complex of urgency, with or without urge incontinence, usually with frequency and nocturia.

The lower urinary tract is innervated by both the parasympathetic and the sympathetic nervous system, that act via muscarinic and adrenergic receptors, respectively.

Antimuscarinics are mainly used for the treatment of patients with OAB, especially women. Other than antimuscarinics, a1-blockers have been shown in several clinical reports to be useful in treating DO caused by neurological diseases.

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Solifenacin intervention 2: Solifenacin plus Tamsulosin
Intervention descriptions: intervention 1: Solifenacin (5mg, qd, oral) intervention 2: Solifenacin (5mg, qd, oral) plus Tamsulosin (0.2mg, qd, oral)

Protocol document: