Conditions: Sedation
Keywords: propofol alfentanil procedural sedation stress biomarkers Deep procedural sedation in the ED
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 20
Healthy volunteers: no

Brief summary:
This is a randomized clinical trial of deep procedural sedation with propofol with and without supplemental alfentanil. Patients will be assessed for total and fractionated serum catecholamines before and after the procedure in addition to usual procedural sedation outcomes parameters to assess the adrenergic effect of propofol sedation without supplemental opioid.

Detailed description:

Arms:
arm 1: propofol only for deep procedural sedation arm 2: Propofol with alfentanil for deep procedural sedation

Interventions: intervention 1: propofol intervention 2: alfentanil
Intervention descriptions: intervention 1: 1 mg/kg IV followed by 0.5 mg/kg iv prn sedation intervention 2: alfentanil 10 ug/kg immediately prior to propofol dose

Protocol document: