Conditions: Hypertension
Keywords: Essential hypertension Uncontrolled hypertension Antihypertensive agents Blood pressure
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 336
Healthy volunteers: no

Brief summary:
This study is being conducted to evaluate the efficacy of MK-0954A in essential hypertension participants who are not adequately controlled with losartan.

Detailed description:

Arms:
arm 1: Participants administered MK-0954A, Placebo for Losartan 50 mg , and Placebo for Losartan 100 mg orally, once daily for 8 weeks. arm 2: Participants administered Losartan 100 mg, Placebo for MK-0954A, and Placebo for Losartan 50 mg orally, once daily for 8 weeks.

Interventions: intervention 1: MK-0954A intervention 2: Losartan intervention 3: Placebo to MK-0954A intervention 4: Placebo to losartan 100 mg intervention 5: Placebo to losartan 50 mg
Intervention descriptions: intervention 1: Tablet containing losartan potassium (100 mg) and hydrochlorothiazide (12.5 mg), once daily intervention 2: Tablet containing losartan potassium (100 mg), once daily intervention 3: Placebo tablet to match MK-0954A, once daily intervention 4: Placebo tablet to match losartan 100 mg, once daily intervention 5: Placebo tablet to match losartan 50 mg, once daily

Protocol document: