Conditions: Urinary Bladder, Overactive
Keywords: Bladder Overactive Overactive urinary bladder Overactive Bladder
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 990
Healthy volunteers: no

Brief summary:
Patients with overactive bladder are often treated with tolterodine, a medication that helps relax the bladder, helping symptoms of urinary incontinence and urinary frequency. Sometimes patients do not have a satisfactory response, and may benefit from trying an alternative oral medicine. Fesoterodine is related to tolterodine by producing the same active substance that acts on the bladder, but potentially at higher and more effective levels. So, a patient who has a poor response to tolterodine may still obtain a good response to fesoterodine. This study will help find out if this is what happens.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Fesoterodine 8 mg intervention 2: Placebo
Intervention descriptions: intervention 1: Fesoterodine sustained release tablets once every morning at 4 mg dose for first week, followed by 11 weeks at 8 mg strength. intervention 2: Matching placebo for fesoterodine 4 and 8 mg for a total of 12 weeks.

Protocol document: