Conditions: Complicated Intra-Abdominal Infection
Keywords: Ceftazidime Meropenem Metronidazole Anti-Bacterial Agents Anti-Infective Agents Antiprotozoal Agents Antiparasitic Agents cIAI, Complicated Intra-Abdominal Infection
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 493
Healthy volunteers: no

Brief summary:
The purpose of this study is to evaluate the effects of Ceftazidime Avibactam plus Metronidazole compared to Meropenem for treating hospitalized patients with complicated intra-abdominal infections.

Detailed description:
A Phase III, Randomized, Multicenter, Double Blind, Double-Dummy, Parallel-Group, Comparative Study to Determine the Efficacy, Safety, and Tolerability of Ceftazidime Avibactam Plus Metronidazole Versus Meropenem in the Treatment of Complicated Intra-Abdominal Infections In Hospitalized Adults

Arms:
arm 1: IV treatment arm 2: IV treatment

Interventions: intervention 1: CAZ-AVI intervention 2: Metronidazole intervention 3: Meropenem
Intervention descriptions: intervention 1: Ceftazidime 2000 mg and 500 mg of avibactam intervention 2: 500 mg of Metronidazole intervention 3: 1 gram of Meropenem

Protocol document: