Conditions: Type 2 Diabetes
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 22
Healthy volunteers: no

Brief summary:
This study investigated the effect of glutamine, an amino acid, glycemia, glucagon-like peptide-1 (GLP-1) and insulin in participants with type 2 diabetes.

Detailed description:
In this study, we investigated the effect of glutamine, an amino acid, on glycemia and on GLP-1 and insulin in participants with type 2 diabetes. Preliminary data published by our group suggests that glutamine is a strong determinant of GLP-1 secretion in vitro. We tested the hypothesis that glutamine lowers postprandial blood glucose and investigated whether the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin modifies this effect.

Arms:
arm 1: Glutamine 30 g/d (15 g with breakfast and dinner) + Sitagliptin arm 2: Glutamine 30 g/d (15 g with breakfast and dinner) + placebo

Interventions: intervention 1: Sitagliptin intervention 2: Placebo
Intervention descriptions: intervention 1: Glutamine 30g +sitagliptin 100mg intervention 2: Glutamine 30g +placebo (matching sitagliptin 100 mg)

Protocol document: