Conditions: Hemangioma Infant
Keywords: topical 0.5% Timolol infantile hemangioma (IH)
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 6
Healthy volunteers: no

Brief summary:
The purpose of this study is to learn about a new potential use for topical timolol 0.5% aqueous solution that may help treat small uncomplicated infantile hemangiomas. This study would examine whether topical timolol could be a potential therapy.

Detailed description:
At the first visit, subjects will fill out a questionnaire that asks about the child's history and the hemangioma. Photographs and measurements will be taken at this and each subsequent visit. At the first visit, subjects will have a physical exam, including vital signs, height and weight. An EKG will also be done. Study drug will be dispensed and instructions given. Half of the subjects will receive a placebo. This is a blinded randomized study. Follow-up visits will be weekly for the first two weeks (three visits total including the first visit), then monthly until the study is over. Photographs and measurements will again be taken at each visit. Subjects will be asked to evaluate the size and the color of the hemangioma against the first photographs and fill out forms regarding any changes in behavior and asked about any side effects.

Arms:
arm 1: Half of the enrolled subjects (intervention group) will receive topical 0.5% Timolol. arm 2: Aqueous placebo, 2-3 drops to cover the hemangioma, twice daily

Interventions: intervention 1: topical 0.5% Timolol intervention 2: Control (placebo) group
Intervention descriptions: intervention 1: topical 0.5% Timolol aqueous solution, 2-3 drops to cover the hemangioma, twice daily intervention 2: Control (placebo) group

Protocol document: