Conditions: Coronary Artery Disease (CAD) Coronary Atherosclerosis
Keywords: CAD coronary artery disease coronary atherosclerosis coronary angiography IVUS intravascular ultrasound plasma renin activity renin angiotensin aldosterone system, direct renin inhibitors coronary atheroma
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 613
Healthy volunteers: no

Brief summary:
The study will assess the change in coronary atherosclerotic disease as determined by intravascular ultrasound (IVUS) for aliskiren compared to placebo when given in addition to standard therapy in patients with coronary artery disease (CAD) and a blood pressure in the pre-hypertensive range.

Detailed description:

Arms:
arm 1: None arm 2: Aliskiren 300 mg

Interventions: intervention 1: Placebo intervention 2: Aliskiren
Intervention descriptions: intervention 1: Placebo intervention 2: 300 mg

Protocol document: