Conditions: Cervical Ripening
Keywords: induced abortion misoprostol cervical ripening second trimester abortion Dilapan-S
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 125
Healthy volunteers: yes

Brief summary:
The purpose of this study is to compare the dilatory effect of 400 mcg of buccally administered misoprostol to one Dilapan-S rod placed 3-4 hours before abortion by dilation and evacuation in women who are 12 weeks 0 days to 15 weeks 0 days gestation.

Detailed description:

Arms:
arm 1: 400mcg buccal misoprostol arm 2: Dilapan-S, control: vitamin B-12 administered sublingually

Interventions: intervention 1: misoprostol intervention 2: Dilapan-S, vitamin B-12
Intervention descriptions: intervention 1: 400mcg misoprostol, buccal administration, 1 time dosing 3-4 hours before abortion by D\&E intervention 2: One Dilapan-S rod placed in the cervix 3-4 hours before abortion by D\&E. Control: 1000mcg vitamin B-12, buccal administration 3-4 hours before abortion by D\&E

Protocol document: