Conditions: General Anesthesia Propofol Target-controlled Infusion Thoracic Epidural Anesthesia
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 80
Healthy volunteers: no

Brief summary:
The investigators designed a prospective, randomized, placebo-controlled study to determine whether thoracic epidural anesthesia(TEA) with different local anesthetics has different influences on the propofol dose during induction.

Detailed description:

Arms:
arm 1: General anesthesia combined with thoracic epidural 0.9% normal saline 8ml arm 2: General anesthesia combined with thoracic epidural 1% lidocaine 8ml arm 3: General anesthesia combined with thoracic epidural 0.25% bupivacaine 8ml arm 4: General anesthesia combined with thoracic epidural 0.3% ropivacaine 8ml

Interventions: intervention 1: Lidocaine intervention 2: Bupivacaine intervention 3: Ropivacaine intervention 4: Normal Saline
Intervention descriptions: intervention 1: General anesthesia combined with thoracic epidural 1% lidocaine intervention 2: General anesthesia combined with thoracic epidural 0.25% bupivacaine intervention 3: General anesthesia combined with thoracic epidural 0.3% ropivacaine intervention 4: General anesthesia combined with thoracic epidural 0.9% normal saline

Protocol document: