Conditions: Atrial Fibrillation
Keywords: Atrial Fibrillation; Ablation
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 60
Healthy volunteers: no

Brief summary:
The primary purpose of this study is to assess the efficacy of oral prednisone in improving the outcomes of pulmonary vein isolation with radiofrequency ablation.

Detailed description:
The purpose of this study is:

1. To assess the efficacy of oral prednisone in improving the outcomes of pulmonary vein isolation with radiofrequency ablation.
2. To measure the inflammatory cytokine (TNF-α, IL-1, IL-6, IL-8) response to radiofrequency ablation for atrial fibrillation with or without prior prednisone treatment.

Arms:
arm 1: Participants undergo ablation procedure and receive predinisone at protocol determined times. arm 2: Participants undergo ablation procedure and receive placebo at protocol determined times.

Interventions: intervention 1: Prednisone intervention 2: Placebo intervention 3: Ablation Procedure
Intervention descriptions: intervention 1: 60mg of oral prednisone 2 days before procedure, day of procedure, and 1 day after procedure intervention 2: 60mg placebo pill given 2 days before procedure, day of procedure, and 1 day after procedure intervention 3: Atrial Fibrillation (AF) ablation

Protocol document: