Conditions: Healthy
Keywords: HSV Herpes volunteers drug-drug interaction
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 24
Healthy volunteers: yes

Brief summary:
CYP2C8 is involved in the metabolism of many drugs. So, it is important to assess in vivo the inhibitory effect of ASP2151 on that enzyme to determine any possible drug interactions. The aim of this trial is to investigate the potential for interaction of ASP2151 with the CYP2C8 probe substrate montelukast.

Detailed description:

Arms:
arm 1: 10mg montelukast alone followed by 10mg montelukast + 400mg ASP2151 arm 2: 10mg montelukast + 400mg ASP2151 followed by 10mg montelukast alone

Interventions: intervention 1: Montelukast intervention 2: ASP2151
Intervention descriptions: intervention 1: None intervention 2: None

Protocol document: