Conditions: Healthy Volunteers
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 40
Healthy volunteers: yes

Brief summary:
The purposes of this study are to determine the effects of baricitinib on the time it takes to remove simvastatin from the body and to look at how well-tolerated and safe baricitinib is when given alone and in combination with simvastatin. Side effects will be documented. The study will last approximately 7 days from the first dose to the end of the study (not including screening or follow-up).

Detailed description:

Arms:
arm 1: Single oral dose of 40 milligrams (mg) simvastatin on Day 1. arm 2: Oral doses of 10 mg baricitinib once daily (QD) on Days 3 to 7, with a single oral dose of 40 mg simvastatin coadministered on Day 6.

Interventions: intervention 1: Baricitinib intervention 2: Simvastatin
Intervention descriptions: intervention 1: Administered orally intervention 2: Administered orally

Protocol document: