Conditions: OHSS (Ovarian Hyperstimulation)
Keywords: GnRH antagonist GnRH agonist hCG OHSS In vitro fertilization ovulation induction Clinical pregnancy rate
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 384
Healthy volunteers: no

Brief summary:
The purpose of this study is to possibly further improve the clinical outcome and explore the incidence of OHSS in patients, who have final oocyte maturation with GnRHa (Buserelin) in GnRH antagonist IVF/ICSI cycles

Detailed description:

Arms:
arm 1: More than 14 follicles with a diameter of \> 11mm: triggering of ovulation with 0.5 mg GnRHa (Buserelin) (s.c.) + 1500 IU hCG (Pregnyl) arm 2: More than 14 follicles with a diameter of \> 11mm: triggering of ovulation with hCG (Pregnyl) 5.000 IU (s.c.) arm 3: 14 or less follicles with a diameter of \> 11mm: triggering of ovulation with 0.5 mg GnRHa (Buserelin) (s.c.) + 1500 IU hCG (Pregnyl) (s.c.) at 35 hours and 1500 IU hCG (Pregnyl) (s.c.) 7 days after triggering of ovulation (OPU + 5) arm 4: 14 or less follicles with a diameter of \> 11mm: triggering of ovulation with 5000 IU hCG (Pregnyl) (s.c.)

Interventions: intervention 1: Buserelin and Pregnyl intervention 2: Pregnyl intervention 3: Buserelin and Pregnyl intervention 4: Pregnyl
Intervention descriptions: intervention 1: Subcutaneous injection 0.5 mg and 1500 IU intervention 2: Subcutaneous injection 5000 IU intervention 3: Subcutaneous injection 0,5 mg and 1500 IU + 1500 IU after 7 days intervention 4: Subcutaneous injection 5000 IU

Protocol document: