Conditions: Healthy Volunteers Insulin Resistance
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 19
Healthy volunteers: yes

Brief summary:
The purpose of this study is to assess the safety, tolerability, and the effect of food on KQ-791. Each participant may receive up to 3 single doses of KQ-791 (at up to 3 different dose levels) and 1 placebo dose over the course of the study. Up to 6 escalating dose levels may be studied, in two distinct groups or cohorts.

Detailed description:

Arms:
arm 1: Escalating doses of KQ-791, starting at 15 milligrams arm 2: Single dose of KQ-791 in capsule form, after a meal arm 3: Single dose of placebo matching KQ-791 dose

Interventions: intervention 1: KQ-791 intervention 2: KQ-791 (after meal) intervention 3: Placebo
Intervention descriptions: intervention 1: Capsules administered orally while fasting, in up to 3 periods intervention 2: Single dose of KQ-791 in capsules, after a meal, in 1 period intervention 3: Capsules, administered orally, in 1 period

Protocol document: