Conditions: Cardiac Transplantation
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 182
Healthy volunteers: no

Brief summary:
The purpose of this study, in de novo heart transplant patients, is to evaluate whether delayed introduction of everolimus reduces the occurrence of wound healing problems, pericardial and/or pleural effusion and early acute renal insufficiency, as compared with immediate introduction of everolimus, in the firs six months after heart transplantation.

Detailed description:

Arms:
arm 1: None arm 2: delayed introduction) + Cyclosporin + steroids

Interventions: intervention 1: Everolimus intervention 2: Mycophenolate mofetil + Everolimus
Intervention descriptions: intervention 1: None intervention 2: None

Protocol document: