Conditions: Oral Hygiene
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 247
Healthy volunteers: yes

Brief summary:
The primary objectives of this study will be to compare the Gingival Bleeding and Gingival Inflammation following twice daily use of a sodium bicarbonate experimental dentifrice compared to a 0% sodium bicarbonate toothpaste after 24 weeks of use. The study will be conducted at Silverstone Research Group. Participants will be recruited from their database and by use of an external recruitment agency.

Detailed description:

Arms:
arm 1: Experimental dentifrice containing sodium bicarbonate plus 1150 parts per million (ppm) fluoride as sodium fluoride arm 2: Toothpaste containing 1100 ppm fluoride as sodium fluoride

Interventions: intervention 1: Sodium bicarbonate plus sodium fluoride intervention 2: Sodium fluoride
Intervention descriptions: intervention 1: Experimental dentifrice containing sodium bicarbonate plus 1150 parts per million (ppm) fluoride as sodium fluoride intervention 2: Toothpaste containing 1100 ppm fluoride as sodium fluoride

Protocol document: