Conditions: Acne Vulgaris
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 32
Healthy volunteers: yes

Brief summary:
This pilot study will explore if continuation of treatment of treatment with Aczone 5% gel following combination treatment with with doxycycline and Aczone 5% gel can maintain therapeutic response.

Detailed description:
This is a two-center, open-label pilot study. The study is apprised of 7 study visits: Baseline and Weeks 4, 8, 12, 16, 20 and 24. All subjects will receive Aczone 5% gel BID and doxycycline 100mg by mouth once daily at Baseline. Those subjects achieving treatment response (i.e., IGA of 0, 1 or 2) at Week 12 will continue treatment with Aczone 5% gel BID at Week 12. Subjects not achieving treatment response will discontinue study participation.

Arms:
arm 1: Subjects will start treatment with doxycycline 100mg once daily and Aczone 5% gel applied to the face twice daily and those who improve significantly are continued on Aczone gel alone to see if it can maintain therapeutic response

Interventions: intervention 1: Doxycycline 100mg intervention 2: Aczone 5% gel
Intervention descriptions: intervention 1: Doxycycline 100mg by mouth once daily intervention 2: Aczone 5% gel twice daily

Protocol document: