Conditions: Bone Marrow Edema
Keywords: bone marrow edema Aclasta
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 48
Healthy volunteers: no

Brief summary:
The primary aim is to test the reduction of bone marrow edema syndrome after a singular intravenous treatment with Zoledronic Acid within 6 weeks compared to placebo. The volume of the edema is defined as biometric data measured by the use of MRT before and six weeks after treatment. The hypothesis has to be checked whether Zoledronic Acid is efficient in the treatment of painful bone marrow edema. A statistically significant reduction of the edema in the MRT is considered as evidence for efficacy.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Aclasta intervention 2: Placebo
Intervention descriptions: intervention 1: 1 x intravenous non-current drip (infusion) intervention 2: NaCl Solution

Protocol document: