Conditions: Multiple Myeloma CLL / SLL Non Hodgkin's Lymphoma Waldenstroms Mantle Cell Lymphoma
Keywords: Low Grade B Cell Malignancies nonmyeloablative transplant allogeneic
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 5
Healthy volunteers: no

Brief summary:
A non-myeloablative treatment strategy and uniform selection criteria will enable patients with a variety of low grade B-Cell malignancies to attain long term disease control without unacceptably high treatment related mortality.

Detailed description:
Non myeloablative transplant aims to achieve the immunological advantage of graft versus tumor effect as conventional myeloablative therapy without causing high treatment related toxicities. Non myeloablative transplant has been gaining wider acceptance as a way to achieve longer disease free and over all survival in patients with low grade B-cell malignancies, which otherwise is an incurable disease. Recent studies of non-myeloablative HSCT have demonstrated the powerful effect of graft versus leukemia alone against myeloma and other malignant B-cell malignancies if the transplant is performed for low grade, low volume disease.

Arms:
arm 1: Non-myeloablative Transplant Conditioning Chemotherapy :

Fludarabine - 30 mg/m2/day x 3 days Total Body Irradiation - 200cGy x1 dose Infusion of Stem Cells - On Day 0 pts will received an infusion of HLA matched sibling donor stem cells. Dose is determined by the volume of cells obtained from donor. Minimum dose is 2x10\*6 CD34+ cells per kilogram of recipient weight.

Interventions: intervention 1: Fludarabine intervention 2: Total Body Irradiation intervention 3: Infusion of Stem Cells
Intervention descriptions: intervention 1: Fludarabine 30 mg/m2/day x 3 days intervention 2: TBI 200cGy x1 dose on transplant day intervention 3: On Day 0 pts will received an infusion of HLA matched sibling donor stem cells. Dose is determined by the volume of cells obtained from donor. Minimum dose is 2x10\*6 CD34+ cells per kilogram of recipient weight.

Protocol document: