Conditions: Major Depression
Keywords: Depression Anxiety Seroquel Quetiapine fMRI pictures
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 20
Healthy volunteers: no

Brief summary:
The purpose of this study is to find out what parts of the brain have increased or decreased connectivity when people are depressed and how Seroquel extended release (XR) changes this connectivity in depressed patients. The genetic samples collected are to look at variation in a gene (serotonin transporter gene), which affects the functioning of the chemical serotonin in the brain.

Detailed description:
This study will measure the activity and connectivity in different parts of the brain, while the patients are seeing some pictures, using Magnetic Resonance Imaging (MRI) scan. For this study three MRI scans will be conducted. One before the patient begins on any medication, one during the study after 3 weeks of treatment and one after six more weeks of treatment with seroquel.

Arms:
arm 1: Open-label Quetiapine XL 50 - 400 mg daily treatment 8 weeks

Interventions: intervention 1: quetiapine (Seroquel XR)
Intervention descriptions: intervention 1: Seroquel XR (starting dose 100mg and increased up to 400 mg as tolerated) treatment.

Protocol document: