Conditions: Dental Plaque Gingivitis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 179
Healthy volunteers: yes

Brief summary:
The objective of this clinical research study is to assess the efficacy of a commercially available triclosan/copolymer toothpaste compared to a commercially available oral hygiene multi-component regimen encompassing the use of a manual toothbrush, a toothpaste containing stannous fluoride / sodium hexametaphosphate and a mouthwash containing cetylpyridinium chloride relative to a negative control regimen in reducing established dental plaque and gingivitis over three and six months of assigned product use.

Detailed description:

Arms:
arm 1: Triclosan/fluoride toothpaste arm 2: stannous fluoride toothpaste + cetylpyridinium chloride Mouthwash arm 3: Fluoride only toothpaste + Fluoride only Mouthwash

Interventions: intervention 1: Triclosan/fluoride toothpaste intervention 2: stannous fluoride toothpaste intervention 3: fluoride only toothpaste intervention 4: Cetylpyridinium chloride mouthwash intervention 5: Fluoride only mouthwash
Intervention descriptions: intervention 1: Brush whole mouth with Total toothpaste (triclosan/fluoride) using Total 360 toothbrush for 1 minute, 2 times/day for 6 months (study duration). intervention 2: Brush whole mouth with Crest Pro-Health toothpaste using an Oral B Pro-Health toothbrush for 1 minute, 2 times/day for 6 months (study duration). intervention 3: Brush whole mouth with Crest Cavity Protection toothpaste using an Oral B Indicator toothbrush for 1 minute, 2 times/day for 6 months (study duration). Immediately after each brushing, rinse whole mouth with 20 ml of Crest fluoride Mouthwash for 30 seconds. intervention 4: Immediately after each brushing with Crest Pro-Health toothpaste, rinse whole mouth with 20 ml of Crest Pro-Health Mouthwash for 30 seconds. intervention 5: Immediately after each brushing with Crest Cavity Protection toothpaste, rinse whole mouth with 20 ml of Crest Pro-Health For Me mouthwash for 30 seconds.

Protocol document: