Conditions: Postmenopausal Osteoporosis (PMO)
Keywords: Osteoporosis, Osteoporosis-Postmenopausal, Bone Diseases-Metabolic, Bone Diseases, Musculoskeletal Diseases
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 252
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine if treatment with romosozumab increases bone mineral density in Japanese women with postmenopausal osteoporosis.

Detailed description:

Arms:
arm 1: Participants received placebo matching to romosozumab administered by subcutaneous injection once a month for 12 months. arm 2: Participants received 70 mg romosozumab administered by subcutaneous injection once a month for 12 months. arm 3: Participants received 140 mg romosozumab administered by subcutaneous injection once a month for 12 months. arm 4: Participants received 210 mg romosozumab administered by subcutaneous injection once a month for 12 months.

Interventions: intervention 1: Romosozumab intervention 2: Placebo
Intervention descriptions: intervention 1: Administered by subcutaneous injection intervention 2: Administered by subcutaneous injection

Protocol document: