Conditions: Genotype 1 Chronic Hepatitis C
Keywords: Hepatitis, HCV, Liver disease, HepC
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 140
Healthy volunteers: no

Brief summary:
The GI-5005 therapeutic vaccine in combination with standard of care or standard of care alone will be injected under the skin of HCV subjects. Patients will be monitored for safety, immune responses and any therapeutic benefits related to the injections including EVR, ETR, and SVR.

Detailed description:

Arms:
arm 1: GI-5005 monotherapy continuing on to triple therapy arm 2: Standard of care alone

Interventions: intervention 1: GI-5005 intervention 2: Pegylated Interferon and Ribavirin
Intervention descriptions: intervention 1: 40YU, subcutaneous intervention 2: Pegylated interefron is an injection and ribavirin is an oral tablet

Protocol document: