Conditions: Pancreatic Cysts
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 26
Healthy volunteers: no

Brief summary:
Our hypothesis is that a single dose of antibiotics at time of EUS-guided pancreatic cyst aspiration is equally effective to the usual regimen of 3 days of post-procedural antibiotics.

Detailed description:
With the increased use of cross sectional imaging, there appears to be an increasing prevalence of pancreatic cysts being incidentally discovered.

A critical step in the workup of pancreas cysts is to determine whether the cyst is mucinous or non-mucinous, through a procedure called endoscopic ultrasound - fine needle aspiration (EUS-FNA).

Current guidelines suggest the use of antibiotics in cyst aspiration, usually 3 days after the procedure. However, these recommendations are based on limited data from over 15 years ago. More recent retrospective observations suggest equivalent safety when little, or even no antibiotics are given.

Arms:
arm 1: Standard group: this group will receive three days of oral antibiotics after their EUS-guided pancreas cyst aspiration.

Ciprofloxacin 500mg by mouth twice a day for three days. arm 2: Intervention group: this group will receive three days of oral PLACEBO after their EUS-guided pancreas cyst aspiration

Oral Placebo, one cap twice a day for three days.

Interventions: intervention 1: Ciprofloxacin intervention 2: Placebo (for ciprofloxacin)
Intervention descriptions: intervention 1: ciprofloxacin oral capsule (one capsule twice a day for 3 days) intervention 2: oral placebo capsule (one capsule twice a day for 3 days)

Protocol document: