Conditions: Healthy
Keywords: colchicine platelet activity neutrophil
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 10
Healthy volunteers: yes

Brief summary:
This is a pilot study. Volunteers will be given 1.8 mg (1.2 mg followed by 0.6 mg one hour later), 1.2 mg, or 0.6 mg of colchicine. Blood will be collected prior to drug administration, 2 hours after colchicine administration, and 24 hours after colchicine administration via the antecubital vein and evaluated for markers of platelet activity and inflammation.

Detailed description:

Arms:
arm 1: Baseline blood draw followed by colchicine followed by blood draw 2 hours and 24 hours later

Interventions: intervention 1: Colchicine
Intervention descriptions: intervention 1: Colchicine 1.2 mg followed by 0.6 mg one hour later

Protocol document: