Conditions: Stress Disorders, Posttraumatic
Keywords: Stress Disorders, Posttraumatic Hydrocortisone Cycloserine Extinction, Psychological PTSD San Francisco
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 111
Healthy volunteers: yes

Brief summary:
This is a research study examining the use of two medications, Hydrocortisone and D-Cycloserine, compared to an inactive substance (placebo), on their ability to reduce fear responses and memory of fear in Veterans with symptoms of Posttraumatic Stress Disorder (PTSD). These responses will be tested using a fear learning and memory task administered by computer.

Detailed description:

Arms:
arm 1: Hydrocortisone arm 2: D-Cycloserine arm 3: Placebo

Interventions: intervention 1: Hydrocortisone intervention 2: D-Cycloserine intervention 3: Placebo
Intervention descriptions: intervention 1: 25 mg/oral one hour prior to extinction task intervention 2: 50 mg/oral one hour prior to extinction task intervention 3: One hour prior to extinction task

Protocol document: