Conditions: Chronic Constipation
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 13
Healthy volunteers: no

Brief summary:
To evaluate the different effects of prucalopride and PEG 3350 + electrolytes on colon motor activity in subjects that are chronically constipated.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: prucalopride intervention 2: PEG 3350
Intervention descriptions: intervention 1: One 2 mg tablet orally administered on Day 1 intervention 2: 13.8g polyethylene glycol (PEG) 3350 with sodium bicarbonate, sodium chloride, and potassium chloride as a solution in water. Administered twice orally on Day 1(once in the morning and once prior to lunch).

Protocol document: