Conditions: Hypertension Diabetes Mellitus
Keywords: Hypertension Diabetes Mellitus Vascular stiffness Endothelial function
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 30
Healthy volunteers: no

Brief summary:
The purpose of this study is to compare losartan and benazepril in diabetic patients whose high blood pressure is not controlled by amlodipine and its relationship to statin current use.

Detailed description:
Hypertension and diabetes mellitus are important risk factors for cardiovascular morbidity and mortality. Endothelial dysfunction and vascular rigidity are two pathophysiological mechanisms that may explain this relationship. Recent publications showed that both ACEi (angiotensin-converting enzyme inhibitor-induced) and ARB (angiotensin receptor blocker) were capable of improving vascular stiffness and endothelial function, and that these effects occurred despite blood pressure reduction.

This study main objective is to assess if ARB (losartan) effects are different from ACEi (benazepril) in endothelial function in patients with diabetes mellitus type 2 and blood pressure not controlled by amlodipine and its relationship to statin current use.

Secondary analysis of vascular stiffness will be measured by pulse wave velocity and augmentation index. Echocardiographic parameters, such as indexes of diastolic function, will also be measured.

Arms:
arm 1: This group will receive 100 mg of losartan per day. Amlodipine will be maintained. arm 2: This group will receive 20 mg of benazepril per day. Amlodipine will be maintained.

Interventions: intervention 1: Benazepril intervention 2: Losartan
Intervention descriptions: intervention 1: Patients in this group will receive 20 mg of benazepril per day, orally, during 12 weeks. intervention 2: Patients in this group will receive 100 mg of losartan per day, orally, during 12 weeks.

Protocol document: