Conditions: Pulmonary Disease, Chronic Obstructive
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 446
Healthy volunteers: no

Brief summary:
The purpose of the study is to investigate the effect of fluticasone furoate/vilanterol Inhalation Powder on arterial stiffness compared with placebo and vilanterol over a 24-week treatment period in subjects with COPD and aortic pulse wave velocity of 11.0 m/s or above.

Detailed description:

Arms:
arm 1: Inhaled corticosteroid/long acting beta-agonist arm 2: Inhaled long acting beta-agonist arm 3: Placebo

Interventions: intervention 1: Fluticasone Furoate/Vilanterol intervention 2: Vilanterol intervention 3: Placebo
Intervention descriptions: intervention 1: Inhaled corticosteroid/long acting beta-agonist intervention 2: Inhaled long acting beta-agonist intervention 3: Placebo

Protocol document: