Conditions: Diabetes Mellitus
Keywords: Glucose Insulin
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 34
Healthy volunteers: no

Brief summary:
Determine the effect of aldosterone on how the body handles glucose (sugar).

Detailed description:
Determine the effect of aldosterone on glucose metabolism in humans.

Arms:
arm 1: High Sodium diet- Vehicle infusion then Aldosterone infusion Low Sodium diet- Vehicle infusion then Aldosterone infusion arm 2: High Sodium diet- Aldosterone infusion then Vehicle infusion Low Sodium diet- Aldosterone infusion then Vehicle infusion arm 3: Low Sodium diet- Vehicle infusion then Aldosterone infusion High Sodium diet- Vehicle infusion then Aldosterone infusion arm 4: Low Sodium diet- Aldosterone infusion then Vehicle infusion High Sodium diet- Aldosterone infusion then Vehicle infusion

Interventions: intervention 1: Aldosterone infusion (A) intervention 2: Vehicle Infusion (V) intervention 3: High Sodium Diet (HS) intervention 4: Low Sodium Diet (LS)
Intervention descriptions: intervention 1: Infusion of exogenous aldosterone (0.7 mcg/kg/hr for 12.5 hrs) intervention 2: Vehicle infusion for 12.5 hours intervention 3: 160 mmol/d sodium diet for 7 days intervention 4: 20 mmol/d sodium diet for 9 days

Protocol document: