Conditions: Surgical Wound Infections
Keywords: Infection Vancomycin Neurosurgery Stimulator Pump Deep Brain Stimulation Intrathecal Pump
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 214
Healthy volunteers: no

Brief summary:
The goal of this study is to determine whether injecting the antibiotic vancomycin directly into surgical wounds can decrease the rate of infection following implantation of neurosurgical devices.

Detailed description:

Arms:
arm 1: Subjects in the experimental group will receive Vancomycin injected directly into the wound pocket. arm 2: Subjects in the saline group will receive a Saline injection directly into the wound pocket.

Interventions: intervention 1: Vancomycin intervention 2: Placebo (Saline Solution)
Intervention descriptions: intervention 1: Subjects randomized to the vancomycin group will receive an injection (up to 10 mL) of 5 mg/mL vancomycin administered directly into the wound with a blunt needle following watertight fascial closure. intervention 2: Subjects randomized to the saline group will receive an injection (up to 10 mL) of saline solution directly into the wound following watertight fascial closure.

Protocol document: