Conditions: Peripheral Neuropathy Breast Cancer
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 30
Healthy volunteers: no

Brief summary:
Patients with breast cancer receiving paclitaxel chemotherapy who have mild symptoms of peripheral neuropathy will receive glutamine or placebo to try and improve symptoms.

Detailed description:
1. Determine whether oral glutamine supplementation can reduce the symptoms and signs of peripheral neuropathy.
2. Determine whether alterations in the symptoms and signs of peripheral neuropathy are correlated with an alteration of circulating nerve growth factor or insulin-like growth factor levels.
3. Assess whether oral glutamine affects circulating nerve growth factor or insulin-like growth factor levels.
4. Assess whether glutamine interferes with paclitaxel pharmacokinetics

Arms:
arm 1: 10 grams three times a day (orally) for four days and then stop arm 2: 10 grams three times a day (orally) for four days and then stop

Interventions: intervention 1: glutamine intervention 2: Placebo
Intervention descriptions: intervention 1: 10 grams three times a day (orally) for four days and then stop intervention 2: 10 grams three times a day (orally) for four days and then stop

Protocol document: