Conditions: Pulmonary Disease, Chronic Obstructive
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 53
Healthy volunteers: no

Brief summary:
The primary objective of this study is to evaluate the efficacy and safety of orally inhaled tiotropium and olodaterol as both a fixed dose combination and a free combination with respect to lung function and ECG parameters

Detailed description:

Arms:
arm 1: patient will receive tiotropium and olodaterol in a fixed dose combination arm 2: patient will receive tiotropium and olodaterol in a free combination arm 3: patient will receive placebo

Interventions: intervention 1: olodaterol intervention 2: tiotropium intervention 3: Placebo intervention 4: tiotropium intervention 5: olodaterol
Intervention descriptions: intervention 1: free combination with tiotropium intervention 2: free combination with olodaterol intervention 3: None intervention 4: fixed dose combination with olodaterol intervention 5: fixed dose combination with tiotropium

Protocol document: