Conditions: Diabetic Ketoacidosis
Keywords: Diabetes Mellitus Diabetic Ketoacidosis Insulin Glargine Anion gap Metabolic acidosis
Allocation: RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 40
Healthy volunteers: no

Brief summary:
To determine if co-administration of subcutaneous (SQ)Insulin glargine in combination with intravenous (IV) insulin decreases the time to resolution of ketoacidosis and requirement for ICU admission compared to IV insulin with delayed administration of SQ glargine for the treatment of diabetic ketoacidosis (DKA).

Detailed description:

Arms:
arm 1: Patient's with Diabetic Ketoacidosis receiving standard of care treatment with regular insulin drip, IV fluids and close monitoring, with the addition of subcutaneous Insulin Glargine within 2 hours of diagnosis. arm 2: Patient's with Diabetic Ketoacidosis receiving standard of care treatment with regular insulin drip, IV fluids and close monitoring.

Interventions: intervention 1: Insulin Glargine intervention 2: Regular Insulin
Intervention descriptions: intervention 1: None intervention 2: None

Protocol document: