Conditions: Cocaine Dependence
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 18
Healthy volunteers: no

Brief summary:
Repeated drug consumption may progress to problematic use by triggering neuroplastic adaptations that attenuate sensitivity to natural rewards while increasing reactivity to craving and drug cues. Converging evidence suggests that glutamate modulation may work to correct these adaptations and rapidly restore motivation for delayed non-drug rewards relative to immediate drug use. Using an established laboratory model aimed at evaluating behavioral shifts in the salience of cocaine now vs. money later, the investigators will test the effect of CI-581a on cocaine self-administration as compared to the active control.

Detailed description:

Arms:
arm 1: Administration of CI-581a followed 2 weeks later by CI-581b arm 2: Administration of CI-581b followed 2 weeks later by CI-581a

Interventions: intervention 1: CI-581a intervention 2: CI-581b
Intervention descriptions: intervention 1: a 50 minute infusion 24 hours prior to cocaine self-administration session intervention 2: a 50 minute infusion 24 hours prior to cocaine self-administration session

Protocol document: