Conditions: Abscess
Keywords: abscess outcomes antibiotics incision and drainage skin abscess
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 140
Healthy volunteers: yes

Brief summary:
The purpose of this study is to determine if there is a difference between an antibiotic, trimethoprim-sulfamethoxazole versus placebo in healing outcomes of soft tissue abscesses following incision and drainage.

Detailed description:

Arms:
arm 1: Incision and drainage of the abscess and treatment with oral TMP-SMX (100 patients) arm 2: Incision and drainage of the abscess and treatment with oral placebo (100 patients)

Interventions: intervention 1: Trimethoprim-sulfamethoxazole intervention 2: Sugar pill
Intervention descriptions: intervention 1: 10mg/kg/day (based on trimethoprim component), divided twice daily for ten days (maximum dose: 160mg (TMP component) per dose) intervention 2: 10mg/kg/day divided twice daily for ten days. Placebo liquid will contain simple syrup, lactose powder, grape flavor, and food coloring. Placebo capsules will contain lactose powder.

Protocol document: