Conditions: Kidney Failure, Acute Acute Kidney Insufficiency
Keywords: renal kidney injury acute bypass cardiac minocycline prevention Acute Kidney Failure
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 40
Healthy volunteers: no

Brief summary:
This study proposes to investigate whether treatment with minocycline pre-operatively in patients with mild to moderate chronic kidney disease undergoing cardiac surgery will reduce the occurence of kidney injury.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: minocycline intervention 2: placebo
Intervention descriptions: intervention 1: given at least for 4 doses (200mg initially then 100mg every 12 hours until surgery)with maximum of 14 doses intervention 2: placebo will be given for at least 4 doses pre-op to a maximum of 14 doses

Protocol document: