Conditions: Coronary Artery Disease
Keywords: Coronary angiography Percutaneous coronary intervention Contrast media Platelet activity Thrombin generation Fibrinolysis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 100
Healthy volunteers: no

Brief summary:
The aim of this study is to determine how two different types of iodinated contrast media (CM) agents, low-osmolar ionic ioxaglate and iso-osmolar non-ionic iodixanol, affect specific markers of thrombogenesis and platelet function in patients undergoing coronary angiography, and if the use of bivalirudin, a direct thrombin inhibitor used during percutaneous coronary intervention (PCI), affects any contrast-related changes in thrombogenesis and platelet function.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Iodixanol intervention 2: Ioxaglate intervention 3: Bivalirudin
Intervention descriptions: intervention 1: contrast media used during coronary angiography intervention 2: contrast media used during coronary angiography intervention 3: A direct thrombin inhibitor

Protocol document: