Conditions: Diabetes Diabetes Mellitus, Type 2
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 31
Healthy volunteers: no

Brief summary:
This trial is conducted globally. The aim of the trial is to compare sequential addition of insulin aspart versus further dose increase with insulin degludec/liraglutide in subjects with type 2 diabetes mellitus, previously treated with insulin degludec/liraglutide and metformin and in need of further intensification.

This is an extension to trial NN9068-3952, NCT01952145 (DUAL™ V).

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: insulin degludec/liraglutide intervention 2: insulin aspart
Intervention descriptions: intervention 1: Insulin degludec/liraglutide will be given subcutaneously (s.c., under the skin) once daily in combination with metformin.

Dose individually adjusted. intervention 2: Dose titration of insulin aspart will be based on the respective pre-meal(s) and bedtime SMPG measured daily.

Protocol document: