Conditions: Bicuspid Aortic Valve Thoracic Aortic Aneurysm
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 4
Healthy volunteers: no

Brief summary:
The specific aims of this study are to:

* Establish baseline levels of circulating MMP-2 and -9 , TIMP-1and- 2 and TGFB levels in individuals with bicuspid aortic valve and ascending aortic or aortic sinus measurements \>40mm.
* Assess the effect on MMP levels during treatment with losartan, an angiotensin II receptor blocking agent.
* In the setting of losartan therapy for one year, evaluate the response of MMP levels in these patients, and clinical outcomes including effects on aortic growth rate

Detailed description:

Arms:
arm 1: None

Interventions: intervention 1: Cozaar
Intervention descriptions: intervention 1: Angiotensin II Receptor Blocker

Protocol document: