Conditions: Healthy
Keywords: Sleeplessness
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 59
Healthy volunteers: yes

Brief summary:
This study will examine the next-day residual effects of a nighttime dose of gabapentin 250 mg, diphenhydramine citrate 76 mg and triazolam 0.5 mg compared to placebo and each other on simulated driving performance in normal volunteer subjects. It will also examine other measures of next-day performance and next-day sleepiness.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None arm 4: None

Interventions: intervention 1: Gabapentin intervention 2: Diphenhydramine citrate intervention 3: Triazolam intervention 4: Placebo
Intervention descriptions: intervention 1: 250 mg, oral, prior to bedtime on the night before performance testing intervention 2: 76 mg, oral, prior to bedtime on the night before performance testing intervention 3: 0.5 mg, oral, prior to bedtime on the night before performance testing intervention 4: Oral, prior to bedtime on the night before performance testing

Protocol document: