Conditions: ADHD Stimulant-Induced Euphoria
Keywords: ADHD Naltrexone SODAS MPH Stimulant-Induced Euphoria Substance Abuse Adults
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 37
Healthy volunteers: no

Brief summary:
The purpose of this study is to a) assess the efficacy of naltrexone in preventing stimulant-induced euphoria in adults with ADHD, b) assess whether naltrexone will interfere with the clinical efficacy of stimulants in treating adults with ADHD, c) assess whether naltrexone will interfere with the effects of stimulants on neurotransmitter activity. We predict that naltrexone will successfully prevent stimulant-induced euphoria without interfering with the ability of stimulants to effectively treat ADHD in adults. This study will be an 8 -week trial with young adults (18-24) with ADHD.

Detailed description:

Arms:
arm 1: Arm 1: Naltrexone + SODAS MPH arm 2: Arm 2: Placebo + SODAS MPH

Interventions: intervention 1: SODAS MPH intervention 2: Naltrexone
Intervention descriptions: intervention 1: Adults with ADHD will receive open-label SODAS MPH intervention 2: Subjects randomized to the "active" double-blind group will receive Naltrexone HCl

Protocol document: