Conditions: Heartburn
Keywords: Frequent Heartburn Omeprazole Omeprazole, sodium bicarbonate drug combination Gastrointestinal Agents Therapeutic Uses Pharmacologic Actions Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Proton Pump Inhibitors
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 48
Healthy volunteers: yes

Brief summary:
This study will evaluate a single ingredient product (omeprazole 20 mg) with a combination product capsule (omeprazole 20 mg + sodium bicarbonate 1100 mg) in participants with frequent heartburn.

Detailed description:

Arms:
arm 1: Participants will receive omeprazole 20 mg + sodium bicarbonate 1100 mg once a day for 4 days, and then after a washout period, omeprazole 20 mg once a day for 4 days. arm 2: Participants will receive omeprazole 20 mg once a day for 4 days, and then after a washout period, omeprazole 20 mg + sodium bicarbonate 1100 mg once a day for 4 days.

Interventions: intervention 1: Omeprazole 20 mg + Sodium Bicarbonate 1100 mg intervention 2: Omeprazole 20 mg
Intervention descriptions: intervention 1: Capsules, orally intervention 2: Tablets, orally

Protocol document: