Conditions: Upper Gastrointestinal Bleeding
Keywords: upper gastrointestinal bleeding melena hematemesis
Allocation: RANDOMIZED | Intervention model: FACTORIAL
Enrollment: 4
Healthy volunteers: no

Brief summary:
This is a study comparing the effect of erythromycin or metoclopramide, 2 prokinetic drugs (Drugs which are known to speed up the emptying of the stomach or in other words to move the blood out of the stomach faster) given before endoscopy to patients with upper Gastrointestinal bleeding compared to patients who will not receive either of these medications before their endoscopy.

Detailed description:
To compare the efficacy of pre-endoscopic interventions namely erythromycin, metoclopromide vs control in improving the outcomes of endoscopy in ICU patients admitted upper GI bleeding.

Specific aims:

1. Wither erythromycin, metoclopromide vs control can enable visualization of the entire gastric mucosa .
2. Wither erythromycin, metoclopromide vs control can improve the quality of stomach and duodenum visualization: using the scoring system by Fossard et al

Arms:
arm 1: Intravenous erythromycin infusion (dose: 250 mg) 30 min-60 min before procedure arm 2: Intravenous metoclopromide infusion (dose: 10 mg) 30-60 minutes prior to endoscopy arm 3: no medications will be given prior to endoscopy

Interventions: intervention 1: Erythromycin intervention 2: Metoclopromide
Intervention descriptions: intervention 1: None intervention 2: None

Protocol document: