Conditions: Insulin Secretion Insulin Resistance
Keywords: glucagon dipeptidyl peptidase-4 inhibitor
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 85
Healthy volunteers: no

Brief summary:
1. The purpose of this study is to determine whether Sitagliptin therapy suppress glucagon release and improve glucose control in Chinese type 2 diabetic.
2. There are different effects of Sitagliptin therapy on blood glucose regulation, pancreatic alpha \& beta cell function are different in lean (BMI\<25) and overweight (BMI\>25) Chinese type 2 diabetics.
3. The purpose of this study is to determine whether glucagon release may contribute over 30% to the hyperglycemia in Chinese type 2 diabetics.

Detailed description:

Arms:
arm 1: None

Interventions: intervention 1: Sitagliptin
Intervention descriptions: intervention 1: Sitagliptin 100 mg QD for 12 weeks

Protocol document: