Conditions: Acute Myocardial Infarction
Keywords: Acute myocardial infarction Heart Failure Inflammation
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 10
Healthy volunteers: no

Brief summary:
Acute myocardial infarction is characterized by an intense inflammatory response.

The degree of the response influences clinical outcome, with 'more' inflammation promoting heart failure. In this study we plan to determine whether treatment with plasma derived alpha-1 antitrypsin will quench the inflammatory response in patients with acute ST-segment elevation myocardial infarction (STEMI).

Detailed description:

Arms:
arm 1: We will use plasma derived AAT 60 mg/Kg, single infusion, within 12 hours of hospital admission for ST-segment elevation myocardial infarction (STEMI)

Interventions: intervention 1: Alpha 1-Antitrypsin
Intervention descriptions: intervention 1: None

Protocol document: