Conditions: Schizophrenia
Keywords: PF-02545920 safety schizophrenia
Allocation: RANDOMIZED | Intervention model: 
Enrollment: 37
Healthy volunteers: no

Brief summary:
To evaluate the safety and tolerability of multiple doses of PF 02545920 administered orally to psychiatrically stable subjects with schizophrenia receiving background antipsychotic +/- other adjunctive medication.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: PF-02545920 intervention 2: PF-02545920 intervention 3: PF-02545920 intervention 4: Placebo
Intervention descriptions: intervention 1: 15 mg (2 mg X 2d, 5 mg X 2d, 8 mg X 3 d, then 15 mg) Q12h intervention 2: 15 mg (5 mg X 2d, 10 mg X 2d, then 15 mg) Q12h intervention 3: 15 mg (5 mg BID for 7 days 10 mg BID for 7 days, then 15 mg BID for 4 days) Q12h intervention 4: Placebo Q12h

Protocol document: