Conditions: Chronic Pain
Keywords: Chronic pain Child Pediatric Ketamine
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 7
Healthy volunteers: no

Brief summary:
This study is designed to select the most tolerable dose of oral ketamine for children with chronic pain. Children will be given either placebo or one of three dosages of oral ketamine for 2 weeks. The dosage that is most tolerable will be selected for further study.

Detailed description:
Children with chronic pain are randomized to one of four arms (three study drug arms, one placebo arm) in a randomized, double-blinded fashion. Children are treated for 2 weeks and then monitored for an additional 12 weeks. Study participation is a total of 14 weeks.

Arms:
arm 1: A 5mL solution of 0.25 mg/kg/dose of ketamine will be given three times daily for 2 weeks. arm 2: A 5mL solution of 0.5 mg/kg/dose of ketamine will be given three times daily for 2 weeks. arm 3: A 5mL solution of 1 mg/kg/dose of ketamine will be given three times daily for 2 weeks. arm 4: None

Interventions: intervention 1: Ketamine intervention 2: Placebo
Intervention descriptions: intervention 1: Participants on active treatment are given ketamine orally for 2 weeks, at varying dosages (1 dosage per participant). intervention 2: None

Protocol document: