Conditions: Ovarian Cancer
Keywords: Tumor of ovary Surgical blood loss Postoperative blood loss Preventive therapy Thromboembolism
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 100
Healthy volunteers: no

Brief summary:
The purpose of the study is to determine if a standardized single dose tranexamic acid given intravenously immediately preoperatively reduces the perioperative bleeding volume and reduces the need of blood transfusion in women undergoing surgery for advanced ovarian cancer.

Detailed description:

Arms:
arm 1: The group of women receiving Tranexamic acid intravenously immediately before the surgery arm 2: The group of women receiving saline solution (0.9% NaCl) intravenously immediately before the surgery

Interventions: intervention 1: Tranexamic acid intervention 2: 0.9% NaCl solution
Intervention descriptions: intervention 1: Tranexamic acid, 100 mg/ml; 15 mg/kg body weight added to 100 ml 0.9% NaCl solution given as a single dose intravenously immediately prior to skin incision at surgery intervention 2: 0.9% NaCl solution; 0.15 ml/kg body weight added to 100 ml 0.9% NaCl solution. The volume is given intravenously immediate before skin incision at surgery.

Protocol document: