Conditions: Obesity Insulin Resistance
Keywords: Obesity Insulin resistance Mineralocorticoid receptor
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 38
Healthy volunteers: no

Brief summary:
The purpose of this study is to find out if spironolactone, a drug that blocks the action of aldosterone, can make the blood vessels work better in people with obesity. The investigators also want to find out whether spironolactone causes changes in levels of insulin and markers of inflammation.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Spironolactone intervention 2: Placebo
Intervention descriptions: intervention 1: 50 mg once daily for 6 weeks. intervention 2: Placebo-matching spironolactone once daily for 6 weeks.

Protocol document: