Conditions: Duration of Hospitalization
Keywords: Sevoflurane Isoflurane volatile anesthetic duration of hospitalization
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 1584
Healthy volunteers: no

Brief summary:
Preliminary retrospective data suggest that the relatively soluble but inexpensive volatile anesthesia isoflurane prolongs the duration of hospitalization compared to the less soluble but more expensive anesthetic sevoflurane. Even a small reduction in the duration of hospitalization would easily compensate for the modest additional cost of sevoflurane. The investigators therefore propose to test the primary hypothesis that duration of hospitalization is longer with isoflurane than sevoflurane.

The investigators will also test the secondary hypotheses that: 1) pain scores are greater in patients recovering from isoflurane than sevoflurane anesthesia; and, 2) opioid consumption is greater after isoflurane than sevoflurane anesthesia. All statistical analyses will be adjusted for age, gender, race, baseline risk, 9 and procedure.

Detailed description:

Arms:
arm 1: Isoflurane is to be administered to patients in this arm during surgery arm 2: Sevoflurane is to be administered to patients in this arm during surgery

Interventions: intervention 1: Isoflurane intervention 2: Sevoflurane
Intervention descriptions: intervention 1: Isoflurane is administered to patient during surgery as it would normally be administered by the attending anesthesiologist intervention 2: Sevoflurane is administered to patient during surgery as it would normally be administered by the attending anesthesiologist

Protocol document: