Conditions: Bipolar Disorder I or II
Keywords: Major Depressive Episode Depression NOS Bipolar Disorder Bipolar Disorder I Bipolar Disorder II Bipolar Depression Major Depression
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 7
Healthy volunteers: no

Brief summary:
This study seeks to investigate whether tranylcypromine (Parnate®) might be an effective treatment of bipolar depression. New treatments are needed, as there is little evidence that standard antidepressants are effective in treating this condition, and the two antipsychotic medications that have indications for bipolar depression can cause substantial side effects. This study will focus specifically on currently depressed outpatients having a bipolar history for whom at least one standard antidepressant medication was ineffective. Patients will be treated openly with tranylcypromine for 8-10 months, depending on treatment response.

Detailed description:

Arms:
arm 1: Active, open-label tranylcypromine treatment

Interventions: intervention 1: Tranylcypromine
Intervention descriptions: intervention 1: Tranylcypromine, between 10 mg/day and 120 mg/day throughout 16 week study

Protocol document: