Conditions: Human Gut Microbiota
Keywords: healthy volunteers gut microbiota gut microbiome prebiotic probiotic antibiotic antibiotic-associated diarrhea intestinal bacterial overgrowth
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 32
Healthy volunteers: yes

Brief summary:
The purpose of this study is to compare and contrast the effects of a prebiotic (Trametes Versicolor), a probiotic (Saccharomyces boulardii) and an antibiotic (amoxicillin) on the gut microbiota of healthy volunteers. It is expected that treatment will result in the rapid and reproducible alterations in fecal microbiota that will spontaneously reverse in the weeks after treatment is discontinued.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None arm 4: Control group, no intervention given.

Interventions: intervention 1: Trametes versicolor extract intervention 2: Saccharomyces boulardii intervention 3: Amoxicillin
Intervention descriptions: intervention 1: 1,200 mg, 3 times daily on an empty stomach for 14 days intervention 2: 250 mg, 3 times daily on an empty stomach for 14 days intervention 3: 250 mg 3 times daily at least 1 hour before meals for 7 days

Protocol document: