Conditions: Hyperlipidemia
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 69
Healthy volunteers: yes

Brief summary:
This is a study in otherwise healthy Japanese and non-Japanese participants with elevated low density lipoprotein cholesterol (LDL-C). Following single doses of LY3015014, the safety and tolerability of the drug, how the body handles the drug, and the drug's effect on the body will be evaluated. Participants will remain in the study for approximately up to 6 months.

Detailed description:

Arms:
arm 1: A single dose of LY3015014 up to 10.0 milligrams per kilogram (mg/kg) administered IV arm 2: Single dose of LY3015014 10.0 mg/kg administered IV to Japanese participants. Added per protocol amendment effective October, 2012. arm 3: Administered IV once only arm 4: A single dose of LY3015014 up to 3.0 mg/kg administered SC arm 5: A single dose of LY3015014 up to 3 mg/kg administered SC in addition to participant's dose of statin arm 6: Administered SC once only

Interventions: intervention 1: LY3015014 IV intervention 2: Placebo IV intervention 3: LY3015014 SC intervention 4: Placebo SC
Intervention descriptions: intervention 1: Administered IV over 30-90 minutes intervention 2: Administered IV only over 30-90 minutes intervention 3: Administered SC intervention 4: Administered SC

Protocol document: