Conditions: Caries
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 100
Healthy volunteers: yes

Brief summary:
In situ study to compare treatment effect on enamel remineralization potential, measured by surface microhardness recovery (SMHR) and Enamel Fluoride Uptake (EFU). The study will explore the efficacy of an experimental sodium monofluorophosphate (SMFP) dentifrice containing calcium sodium phosphosilicate (CSP) in comparison to an experimental SMFP only dentifrice.

Detailed description:

Arms:
arm 1: Dentifrice containing high fluoride content as SMFP and CSP arm 2: Dentifrice containing high fluoride content as SMFP and no CSP arm 3: Dentifrice containing low fluoride content as SMFP and no CSP arm 4: Dentifrice containing CSP but no fluoride arm 5: Dentifrice containing no CSP and no fluoride

Interventions: intervention 1: Calcium sodium phosphosilicate intervention 2: Sodium monoflurophosphate intervention 3: Placebo
Intervention descriptions: intervention 1: CSP high percentage weight by weight intervention 2: 500 to 1500 parts per million (ppm) of fluoride intervention 3: No CSP and no fluoride

Protocol document: