Conditions: Major Depressive Disorder
Keywords: MDD Cognitive dysfunction
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 598
Healthy volunteers: no

Brief summary:
Major Depressive Disorder (MDD) is a severe and common psychiatric disorder. Although MDD primarily involves mood disturbances, patients also usually present alterations in cognitive function (attention, memory, executive functioning and psychomotor speed). Even though antidepressants are suggested in the literature to potentially improve cognitive dysfunction in patients with MDD to some degree, there is a lack of adequate and well-controlled studies to investigate this effect. This study will evaluate the efficacy, safety and tolerability of a new antidepressant Vortioxetine versus placebo on cognitive dysfunction in adult patients with MDD.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None

Interventions: intervention 1: Placebo intervention 2: Vortioxetine (Lu AA21004) intervention 3: Vortioxetine (Lu AA21004)
Intervention descriptions: intervention 1: capsules; daily; orally intervention 2: encapsulated tablets; daily; orally intervention 3: encapsulated tablets; daily; orally

Protocol document: