Conditions: Atrial Fibrillation
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 48
Healthy volunteers: no

Brief summary:
To investigate the safety, pharmacokinetics, and efficacy following 30-minute continuous intravenous administration of OPC-108459 at 0.4, 0.8, 1.6, or 2.4 mg/kg or placebo to patients with paroxysmal or persistent atrial fibrillation

Detailed description:

Arms:
arm 1: OPC-108459 solution will be intravenously administered by 30-minute infusion in the forearm. arm 2: placebo solution will be intravenously administered by 30-minute infusion in the forearm.

Interventions: intervention 1: OPC-108459 intervention 2: Placebo
Intervention descriptions: intervention 1: None intervention 2: None

Protocol document: