Conditions: Diabetes Melliuts, Type 2
Keywords: Type 2 diabetes safety multiple dose intravenous
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 107
Healthy volunteers: no

Brief summary:
This is a trial in obese subjects who have poor lipid control with and without Type 2 diabetes mellitus to study the safety, tolerability and pharmacokinetics of multiple doses of PF-05231023

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None arm 4: None arm 5: None

Interventions: intervention 1: Placebo intervention 2: 25 mg PF-05231023 intervention 3: 50 mg PF-05231023 intervention 4: 100 mg PF-05231023 intervention 5: 150 mg PF-05231023
Intervention descriptions: intervention 1: 0.9% w/v sodium chloride injection, United States Pharmacopeia (USP), once a week for 4 weeks intervention 2: 25 mg IV once a week for 4 weeks intervention 3: 50 mg IV once a week for 4 weeks intervention 4: 100 mg IV once a week for 4 weeks intervention 5: 150 mg IV once a week for 4 weeks

Protocol document: