Conditions: Kidney Transplant
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 229
Healthy volunteers: no

Brief summary:
The primary objective of the study is to determine the efficacy of ramipril in preventing a urinary protein to creatinine ratio (U p/c) greater than 0.5 following conversion to sirolimus from a calcineurin inhibitor (CNI) in maintenance kidney transplant patients.

Detailed description:

Arms:
arm 1: Capsule - initial treatment is 5 mg (active)- oral - once per day arm 2: Capsule - initial treatment is 5 mg (placebo) - oral - once per day

Interventions: intervention 1: ramipril intervention 2: ramipril
Intervention descriptions: intervention 1: Capsule - initial treatment is 5 mg (active)- oral - once per day intervention 2: Capsule - initial treatment is 5 mg (placebo) - oral - once per day

Protocol document: