Conditions: Symptomatic Orthostatic Hypotension
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 98
Healthy volunteers: no

Brief summary:
To study the effect of midodrine against the symptoms of orthostatic hypotension

Detailed description:
The efficacy of midodrine will be assessed in those subjects who have severe symptoms of orthostatic hypotension when not taking midodrine and are controlled when taking midodrine. The study will involve approximately 9 overnight stays.

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Midodrine HCl intervention 2: Placebo
Intervention descriptions: intervention 1: dose at subject's current dose level intervention 2: single dose of matching placebo

Protocol document: