Conditions: Heart Failure With Reduced Ejection Fraction
Keywords: Heart failure, reduced ejection fraction, LCZ696, titration, safety, tolerability
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 498
Healthy volunteers: no

Brief summary:
The purpose of this study is to assess the safety and tolerability of initiating LCZ696 in heart failure patients with reduced ejection fraction (HF-rEF) using conservative (reaching target dose over 6 weeks) and condensed (reaching target dose over 3 weeks) up-titration regimens.

Detailed description:

Arms:
arm 1: Up-titration to LCZ696 200 mg twice daily (bid) over 3 weeks arm 2: Up-titration to LCZ696 200 mg bid over 6 weeks

Interventions: intervention 1: LCZ696
Intervention descriptions: intervention 1: LCZ696 50 mg/100 mg/200 mg bid

Protocol document: