Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Keywords: COPD Antimuscarinic
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 112
Healthy volunteers: no

Brief summary:
The aim of the present study is to evaluate the effect of aclidinium bromide 400 μg twice a day (BID) administered twice a day versus placebo on exercise endurance and on hyperinflation and dyspnoea at rest and during exercise after 3 weeks of treatment.

Detailed description:

Arms:
arm 1: 3-week treatment periods arm 2: 3-week treatment periods

Interventions: intervention 1: Aclidinium Bromide intervention 2: Placebo
Intervention descriptions: intervention 1: 1 puff of 400 micro grams in the morning (09:00 ± 1h) and in the evening (21:00 ± 1h) intervention 2: 1 puff of placebo in the morning (09:00 ± 1h) and 1 puff in the evening (21:00 ± 1h)

Protocol document: