Conditions: Rosacea
Keywords: Rosacea Dermatology UCSD Skin disease
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 15
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine the effect of topical aminocaproic acid on the immune system by assessing the levels of antimicrobial peptides in the skin of patients with rosacea. It is hypothesized that aminocaproic acid applied topically will alter the body's immune system in patients with rosacea by inhibiting activation of antimicrobial peptides.

Detailed description:

Arms:
arm 1: Subjects will treat their facial skin twice daily for up to 12 weeks with 5-6 visits and 2 telephone visits. Investigator and subject will be blinded. Tape strip samples will be collected from facial skin at each visit to assess Kallikrein 5 (KLK5) activity. arm 2: Subjects will apply vehicle twice daily for up to 12 weeks with 5-6 visits and 2 telephone visits. Investigator and subject will be blinded. Tape strip samples will be collected from facial skin at each visit to assess Kallikrein 5 (KLK5) activity.

Interventions: intervention 1: Topical aminocaproic acid (ACA) mixed with Vanicream intervention 2: Vehicle cream
Intervention descriptions: intervention 1: 25% Aminocaproic acid cream twice daily for up to 12 weeks. intervention 2: Vehicle cream moisturizer twice daily for up to 12 weeks

Protocol document: