Conditions: Cocaine Use Disorder Alcohol Use Disorder
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 30
Healthy volunteers: no

Brief summary:
The purpose of this research study is to determine whether a medication called pioglitazone (trade name Actos) can reduce behavioral problems associated with cocaine use, improve brain structural changes associated with cocaine use and reduce cocaine craving and drug use in cocaine dependent patients.

Detailed description:

Arms:
arm 1: Subjects randomized to pioglitazone begin with a starting dose of 15 mg daily administered. The dose will be titrated up to 30mg on the second week and 45 mg on the third week of the study. Subjects will remain on 45 mg of pioglitazone until the end of week 12. At the end of week 12 the study medication will be discontinued. arm 2: Subjects randomized to placebo receive placebo capsules once daily across all twelve weeks of the study.

Interventions: intervention 1: Pioglitazone intervention 2: Placebo intervention 3: Therapy intervention 4: Contingency Management
Intervention descriptions: intervention 1: Subjects randomized to pioglitazone begin with a starting dose of 15 mg daily administered. The dose will be titrated up to 30mg on the second week and 45 mg on the third week of the study. Subjects will remain on 45 mg of pioglitazone until the end of week 12. At the end of week 12 the study medication will be discontinued. intervention 2: Subjects randomized to placebo receive placebo capsules once daily across all twelve weeks of the study. intervention 3: Cognitive-behavioral therapy 1 hour per week intervention 4: Prize-based contingency management for attendance

Protocol document: