Conditions: Diabetes Pre-hypertension Hypertension
Keywords: aliskiren endothelial function hypertension
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 21
Healthy volunteers: no

Brief summary:
The study will evaluate the effects of the direct renin inhibitor, aliskiren, on flow-mediated dilation of the brachial artery and on central aortic pressure in diabetic patients with pre-hypertension or Stage 1 hypertension.

Detailed description:
Patients are double-blind placebo-controlled randomized to either aliskiren or sugar pill/placebo. Effects on blood parameters and arteries are evaluated in both groups.

Arms:
arm 1: aliskiren 300 mg daily arm 2: Patients were double-blind placebo-controlled randomized to either aliskiren 300 mg once daily or sugar pill/ placebo

Interventions: intervention 1: aliskiren 300 mg once daily intervention 2: Placebo/sugar pill
Intervention descriptions: intervention 1: aliskiren 300 mg daily intervention 2: Sugar pill/placebo

Protocol document: