Conditions: Osteoporosis
Keywords: AMG 785, bone mineral density, alendronate
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 60
Healthy volunteers: no

Brief summary:
The purpose of this study is to estimate the percent change from baseline in lumbar spine bone mineral density (BMD) following multiple-dose administrations of romosozumab in postmenopausal women with low BMD previously treated with alendronate.

Detailed description:

Arms:
arm 1: Participants received romosozumab 140 mg administered subcutaneously once a month for 3 months. arm 2: Participants received romosozumab 210 mg administered subcutaneously once a month for 3 months.

Interventions: intervention 1: Romosozumab
Intervention descriptions: intervention 1: Administered by subcutaneous injection

Protocol document: