Conditions: Healthy Subjects
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 20
Healthy volunteers: yes

Brief summary:
This study compared the pharmacokinetics (PK) and assessed the safety of delayed-release metformin (Met DR, EFB0027) at two dosage levels, immediate-release metformin (Met IR, ETB0015), and extended-release metformin (Met XR, ETB0014) in healthy subjects.

Detailed description:

Arms:
arm 1: Two doses of 500 mg metformin delayed-release arm 2: Two doses of 1000 mg metformin delayed-release arm 3: Two doses of 1000 mg metformin immediate-release arm 4: Single dose of 2000 mg metformin extended-release

Interventions: intervention 1: Met DR intervention 2: Met XR intervention 3: Met IR
Intervention descriptions: intervention 1: metformin delayed-release tablets intervention 2: metformin extended-release tablets intervention 3: metformin immediate-release tablets

Protocol document: