Conditions: Gastrointestinal Motility Disorder
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 16
Healthy volunteers: yes

Brief summary:
This is a single-center, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, and pharmacokinetics (PK) of repeated IV doses of TD-8954 in healthy adults 18 to 45 years of age and healthy elderly subjects 65 to 85 years old. A healthy elderly subject population is included to evaluate the safety, tolerability, and PK of TD-8954 IV. Pharmacodynamic effects on bowel movements will also be evaluated. Screening for all cohorts will be conducted within 21 days before the first dose.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None

Interventions: intervention 1: TD-8954 intervention 2: Placebo - saline
Intervention descriptions: intervention 1: Intravenous infusion intervention 2: Intravenous infusion

Protocol document: