Conditions: Chronic Obstructive Pulmonary Disease COPD
Keywords: COPD Chronic obstructive pulmonary disease
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 3
Healthy volunteers: no

Brief summary:
This study in Chronic Obstructive Pulmonary Disease (COPD) patients will investigate the bronchodilatory effect of AZD8683. AZD8683 will be tested versus placebo and an active comparator.

Detailed description:
A randomised, double-blind placebo- and active-controlled, multi-centre, 6-way cross-over, single-dose phase IIa study to investigate the bronchodilatory and systemic effects of 4 different doses of inhaled AZD8683 in patients with Chronic Obstructive Pulmonary Disease (COPD).

Arms:
arm 1: Single dose of AZD8683 50 µg arm 2: Single dose of AZD8683 150 µg arm 3: Single dose of AZD8683 300 µg arm 4: Single dose of AZD8683 900 µg arm 5: Single dose of placebo arm 6: Single dose of tiotropium 18 µg

Interventions: intervention 1: AZD8683 intervention 2: Placebo intervention 3: Tiotropium
Intervention descriptions: intervention 1: AZD8683 administered via inhalation intervention 2: Placebo administered via inhalation intervention 3: Tiotropium administered via inhalation

Protocol document: