Conditions: Diabetes Mellitus, Type 2
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 24
Healthy volunteers: no

Brief summary:
This study will look into insulin sensitivity (how the body responds to insulin) and effects of meals on type 2 diabetics comparing insulin peglispro to insulin glargine. The study has two treatment periods, each of which will last about four weeks. One drug (insulin peglispro or insulin glargine) will be administered in each period. Participants will receive both drugs during the study. Participants may remain on stable dose metformin, as prescribed by their personal physician.

Detailed description:

Arms:
arm 1: Insulin peglispro, a once daily subcutaneous(SC) injection at bedtime for 5 weeks arm 2: Insulin glargine, a once daily subcutaneous(SC) injection at bedtime for 5 weeks

Interventions: intervention 1: Insulin Peglispro intervention 2: Insulin Glargine intervention 3: Insulin Lispro
Intervention descriptions: intervention 1: Administered subcutaneously (SC), (U-100 formulation) intervention 2: Administered subcutaneously (SC), (U-100 formulation) intervention 3: Administered subcutaneously (SC), (U-100 formulation)

Protocol document: