Conditions: Solid Tumors
Keywords: PF-04449913 Hedgehog Inhibitor Solid tumor Pharmacokinetics Safety Pharmacodynamics
Allocation: NON_RANDOMIZED | Intervention model: SEQUENTIAL
Enrollment: 23
Healthy volunteers: no

Brief summary:
This study examines the effect of a small molecule inhibitor to the Sonic Hedgehog pathway on select solid tumors.

Detailed description:

Arms:
arm 1: None

Interventions: intervention 1: PF-04449913
Intervention descriptions: intervention 1: Escalating dose of PF-04449913 administered as tablets PO QD in 28-day cycles

Protocol document: