Conditions: Chronic Kidney Disease
Keywords: Renal blood flow Regional renal blood flow MRI
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 10
Healthy volunteers: no

Brief summary:
Comparison of renal blood flow measurements by PAH clearance and MRI

Detailed description:
The traditional measurement of renal blood flow in ml/min involves the collection of multiple blood and urine samples after an infusion of a drug called para-aminohippurate (PAH) is given. In this study, the investigators determine the ability of MRI to estimate renal blood flow. The primary hypothesis is that renal blood flow as measured by PAH clearance is similar to renal blood flow as estimated by MRI. The measurements by PAH clearance and MRI are both performed on the same day.

Arms:
arm 1: PAH measure of renal blood flow is first performed on subjects prior to administration of furosemide arm 2: After the PAH measurement is complete, subjects receive 20 mg furosemide and undergo BOLD MRI to estimate renal blood flow

Interventions: intervention 1: Furosemide intervention 2: Placebo
Intervention descriptions: intervention 1: Renal blood flow is measured after the administration of 20 mg of furosemide during MRI scan only. intervention 2: None

Protocol document: