Conditions: Chronic Allergic Conjunctivitis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 16
Healthy volunteers: no

Brief summary:
The purpose of this study is to evaluate the effectiveness of the modified Conjunctival Allergen Challenge (CAC) and observe how the produced allergic inflammation reacts to treatment with a proven ocular anti-inflammatory medication,

Prednisolone, assessed by the following measures:

Chronic Allergic Inflammation assessed using confocal microscopy Ocular itching Conjunctival redness

Detailed description:
Prospective, single center, randomized, double-masked, placebo controlled study. Subjects will be randomized to one of the following treatment arms to dose four times per day (QID) for 4 days between Visits 3 and 4.

Prednisolone phosphate Tears Naturale II Ophthalmic Solution (Placebo)

Duration:

Approximately 2 weeks

Controls:

Artificial Tears (Tears Naturale® II)

Arms:
arm 1: Prednisolone Sodium Phosphate Ophthalmic Solution, 1% arm 2: Tears Naturale II Ophthalmic Solution, 1%

Interventions: intervention 1: Prednisolone Sodium Phosphate Ophthalmic Solution 1% intervention 2: Tears Naturale II Ophthalmic Solution
Intervention descriptions: intervention 1: One drop in each eye, four times/day for 4 days. intervention 2: one drop in each eye, four times/ day (QID) for 4 days

Protocol document: