Conditions: Diabetic Foot
Keywords: Diabetic Foot,MRSA, Complicated skin and skin structure infections Antimicrobial therapy Daptomycin
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 1
Healthy volunteers: no

Brief summary:
Objective of the study is to test whether Daptomycin (6 mg/kg bodyweight) is non-inferior in treatment of severe diabetic foot infections (MRSA) in comparison to antibiotic treatment with Vancomycin (effective blood-plasma concentration of 15 mg/l). In case of microbiologically confirmed gram-negative co-infection effective antibiotic treatment according to microbiologic analysis will be administered upon medical decision in both therapy groups. The study will be carried out as a randomized, open label study.

Detailed description:

Arms:
arm 1: Infusion of Daptomycin (6 mg/kg bodyweight) once daily arm 2: Vancomycin once daily (effective blood-plasma concentration of 15 mg/l)

Interventions: intervention 1: Daptomycin intervention 2: Vancomycin
Intervention descriptions: intervention 1: Infusion (6 mg/kg/bodyweight) once daily intervention 2: vancomycin once daily (effective blood-plasma concentration of 15 mg/L)

Protocol document: