Conditions: Hernia
Keywords: Herniotomy
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 200
Healthy volunteers: no

Brief summary:
The aim of the study is the assessment and management of Acute Post-herniotomy Pain using two different therapeutical protocols per os: ketorolac versus association of acetaminophene+tramadol.

Detailed description:
Persistent post-herniotomy pain (PPP) affects everyday activities in 5-10% of patients. Even brief intervals of acute pain can induce long-term neuronal remodeling and sensitization, chronic pain and lasting psychological distress. Chronic pain may be caused by intense acute PPP, intraoperative nerve injury and/or ongoing inflammation or mesh response with subsequence damage to nerve structures. The aim of our study is to analyze analgesic efficacy, safety and prevention of persistent postsurgical pain of two different pharmacological strategies.

Arms:
arm 1: Patients will be given intraoperative analgesia with Ketorolac and tramadol before the the end of surgery, then Ketorolac postoperative 10mg 1cp x 3/die, from the day of surgery for 4 days after surgery. arm 2: Patients will be given intraoperative analgesia with Ketorolac and tramadol before the the end of surgery, then postoperative Patrol (acetaminophene 325mg+tramadol 37,5mg) 1cp x 3/die for 4 days after surgery.

Interventions: intervention 1: Ketorolac postoperative intervention 2: postoperative Patrol intervention 3: intraoperative analgesia intervention 4: intraoperative analgesia
Intervention descriptions: intervention 1: Ketorolac 10mg 1cp x 3/die intervention 2: acetaminophene 325mg+tramadol 37.5mg, 1cp x 3/die intervention 3: ketorolac 30 mg iv intervention 4: Tramadol 100 mg if Weight over 50 kg, 50 mg if weight below 50 kg

Protocol document: