Conditions: Arterial Hypertension
Keywords: chlortalidone amiloride arterial hypertension
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 246
Healthy volunteers: no

Brief summary:
The purpose of this study is to assess the efficacy and safety of Chlorthalidone 25 mg + amiloride hydrochloride 5 mg association in the treatment of elderly patients with arterial hypertension.

Detailed description:
To assess the efficacy and safety of the association of Chlorthalidone 25 mg + amiloride hydrochloride 5 mg (Diupress® Eurofarma) in the treatment of elderly patients with arterial hypertension, compared to Chlorthalidone 25mg (Higroton® Laboratório Novartis) in same presentation form.

Some eligibility criteria:

perform blood and urine tests; ECG (electrocardiogram); ABPM (Ambulatory Blood Pressure Monitoring; Echocardiogram;Doppler Echocardiogram

Arms:
arm 1: Chlorthalidone 25mg - one oral tablet a day in the morning arm 2: Chlorthalidone 25 mg + amiloride hydrochloride 5 mg - one oral tablet a day in the morning

Interventions: intervention 1: Chlorthalidone 25 mg + amiloride hydrochloride 5 mg intervention 2: Higroton® Laboratório Novartis
Intervention descriptions: intervention 1: Chlorthalidone 25 mg + amiloride hydrochloride 5 mg - one oral tablet a day in the morning during approximately 12 weeks intervention 2: Chlortalidone 25mg - oral tablet a day in the morning during approximately 12 weeks

Protocol document: