Conditions: Kidney Disease Kidney Failure, Chronic
Keywords: Transplant Failure Kidney
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 10
Healthy volunteers: no

Brief summary:
The purpose of this study is to evaluate the effect of a short-term aliskiren treatment on kidney metabolism in patients at high risk for developing kidney dysfunction (i.e. kidney transplanted patients). The study is aimed at evaluating if any effect on kidney metabolism \[using proton MR Spectroscopy(1H-MRS)\] can be detected following a 6 months treatment with aliskiren regardless of its anti-hypertensive role. 1H-MRS can record a larger number of chemical species (up to 40) in the kidney, and monitor changes according to the pathologic state and health of the transplanted kidney.

Detailed description:

Arms:
arm 1: Aliskiren 150 mg daily for 180 days arm 2: Placebo identical to Aliskiren drug daily for 180 days

Interventions: intervention 1: Aliskiren intervention 2: Placebo
Intervention descriptions: intervention 1: Take 1 tablet (150 mg) by mouth daily for 180 days intervention 2: Take 1 tablet (0 mg) daily for 180 days.

Protocol document: