Conditions: Healthy Volunteers
Keywords: human Gut Microbiota gut microbiota gut microbiome probiotic antibiotic antibiotic-associated diarrhea intestinal bacterial overgrowth
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 53
Healthy volunteers: yes

Brief summary:
The purpose of this study is to compare and contrast the effects of the probiotic Saccharomyces boulardii, the antibiotic amoxicillin/clavulanate and the combination on the gut microbiota of healthy volunteers.

Detailed description:

Arms:
arm 1: 500 mg, 2 times daily for 14 days arm 2: 875/125 mg 2 times daily at least 1 hour before meals for 7 days arm 3: Amoxicillin Clavulanate for 7 days (days 1 to 7; 875/125 mg 2 times daily at least 1 hour before meals) in addition to the dietary supplement Saccharomyces boulardii for 14 days (days 1 to 14; 500 mg, 2 times daily). arm 4: None

Interventions: intervention 1: Saccharomyces boulardii intervention 2: Amoxicillin Clavulanate
Intervention descriptions: intervention 1: 500 mg, 2 times daily for 14 days intervention 2: 875/125 mg 2 times daily at least 1 hour before meals for 7 days

Protocol document: