Conditions: Cardiovascular Disease Chronic Kidney Disease
Keywords: cardiovascular disease angiotensin converting enzyme inhibitors chronic kidney disease cardiovascular disease in elderly patients with CKD
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 43
Healthy volunteers: yes

Brief summary:
The goal of this proposal is to investigate the potential for ACE-inhibitors (ACE-I)(drugs primarily used to treat hypertension or congestive heart failure) to prevent or delay cardiovascular disease (CVD) in older adults with chronic kidney disease (CKD) by examining their impact on aortic stiffness in people with stage 3 CKD in a randomized, controlled study.

Detailed description:
This study will be the first to examine whether aortic stiffness is increased in elderly patients with CKD compared to their age-matched healthy controls and further examine whether ACE-I may delay the progression of aortic stiffness in elderly CKD patients. If ACE-I therapy appears beneficial in preventing or delaying arterial stiffening in elderly patients with CKD, this work has important implications for improving the overall health of this population.

Arms:
arm 1: ace inhibitor arm 2: None arm 3: ace-inhibitor arm 4: Placebo

Interventions: intervention 1: angiotensin converting enzyme inhibitor intervention 2: lisinopril
Intervention descriptions: intervention 1: Active comparator in chronic kidney disease and age matched control will take 1x40mg per day Placebo comparator in chronic kidney disease and age matched control will take 1 placebo pill per day intervention 2: 1 x 40 mg per day

Protocol document: