Conditions: Rheumatoid Arthritis
Keywords: Safety and tolerability Pharmacokinetics Pharmacodynamics PF-04236921
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 41
Healthy volunteers: no

Brief summary:
This study will evaluate the safety and tolerability of PF-04236921 administered monthly as three intravenous infusions. Each group of patients will be assigned to a dose level; Safety and tolerability of a low dose level will be required before proceeding to successively higher dose levels. Blood tests will be performed to measure the amount of drug and changes in measures of inflammation.

Detailed description:
Safety and Tolerability and Pharmacokinetic/Pharmacodynamic assessment of inflammation-related biomarkers.

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Placebo intervention 2: dose level 1 intervention 3: dose level 2 intervention 4: dose level 3 intervention 5: dose level 4
Intervention descriptions: intervention 1: intravenous infusion on three consecutive months intervention 2: intravenous infusion on three consecutive months intervention 3: intravenous infusion on three consecutive months intervention 4: intravenous infusion on three consecutive months intervention 5: intravenous infusion on 3 consecutive months

Protocol document: