Conditions: Healthy
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 61
Healthy volunteers: yes

Brief summary:
The investigators will compare the effects of rapid release aspirin and NHP-544C on the prostacyclin response to intravenous bradykinin.

Detailed description:

Arms:
arm 1: Group 1 will be randomized to the order in which they receive rapid-release aspirin (ASA), 81 mg), ASA 162.5 mg, and identical-appearing placebo for 5 days. Bradykinin will be given intravenously in graded doses on the fifth day of each treatment period. arm 2: Group 2 will be randomized to the order in which they receive NHP-544C 81 mg, NPH-544C 162.5 mg and identical-appearing placebo for five days. Bradykinin will be given intravenously in graded doses on the fifth day of each treatment period.

Interventions: intervention 1: Bradykinin intervention 2: Aspirin 81 mg intervention 3: Aspirin 162 mg intervention 4: NHP544-C 81 mg intervention 5: NHP544C 162 mg intervention 6: Placebo
Intervention descriptions: intervention 1: Bradykinin will be given intravenously in graded doses. Each dose will be given for 15 minutes. intervention 2: Subjects will take Aspirin 81 mg per day for five days. intervention 3: Subjects will take aspirin 162 mg per day for 5 days. intervention 4: Subjects will take NHP544C 81 mg per day for five days. intervention 5: Subjects will take NHP544C 162 mg once a day for five days. intervention 6: Subjects will take matching placebo for five days.

Protocol document: