Conditions: Knee Osteoarthritis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 338
Healthy volunteers: no

Brief summary:
This clinical trial is planned to prove Entelon tab. arm is not inferior to Celebrex cap. arm in terms of the efficacy and safety through the change of K-WOMAC's total score sum in patients with osteoarthritis of knee.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None

Interventions: intervention 1: Enteron tab. 150mg(vitis vinifera extract 150mg) : twice daily for 12 weeks intervention 2: Celebrex cap. (celecoxib 200mg) : once daily, for 12 weeks intervention 3: Placebo
Intervention descriptions: intervention 1: 1. morning : 1 tab. of active Entelon 150mg plus 1 cap. of placebo Celebrex
2. evening : 1 tab. of active Entelon 150mg intervention 2: 1. morning : 1 tab. of placebo Entelon 150mg + 1 cap. of active Celebrex
2. evening : 1 tab. of placebo Entelon 150mg intervention 3: 1. morning : 1 tab. of placebo Entelon 150mg + 1 cap. of placebo Celebrex
2. evening : 1 tab. of placebo Entelon 150mg

Protocol document: