Conditions: Acne Vulgaris
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 304
Healthy volunteers: no

Brief summary:
To assess the efficacy and safety of different concentrations of CD5789 cream in participants with acne vulgaris for the purpose of dose identification.

Detailed description:

Arms:
arm 1: Participants randomized in stratum 1, 2 and 3 were applied with 25 mcg/g CD5789 cream, once daily for 12 weeks. arm 2: Participants randomized in stratum 1, 2 and 3 were applied with 50 mcg/g CD5789 50 once daily for 12 weeks. arm 3: Participants randomized in stratum 1, 2 and 3 were applied with 100 mcg/g CD5789 cream, once daily for 12 weeks. arm 4: Participants randomized in stratum 1 and 2 were applied with Tazarotene 0.1% Gel, once daily for 12 weeks. arm 5: Participants randomized in stratum 1, 2 and 3 were applied with Vehicle Cream once daily for 12 weeks.

Interventions: intervention 1: CD5789 25 µg/g cream intervention 2: CD5789 50 µg/g cream intervention 3: CD5789 100 µg/g cream intervention 4: Tazarotene 0.1% gel intervention 5: Vehicle cream
Intervention descriptions: intervention 1: CD5789 25 µg/g cream applied once daily intervention 2: CD5789 50 µg/g cream applied once daily intervention 3: CD5789 100 µg/g cream applied once daily intervention 4: Tazarotene 0.1% gel applied once daily intervention 5: Vehicle cream applied once daily

Protocol document: