Conditions: Cocaine Dependence
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 9
Healthy volunteers: no

Brief summary:
Cocaine-use disorders continue to be a significant public health concern, yet no effective medications have been identified. The goal of this study is to establish a research platform for the development of medications for treatment of cocaine abuse and dependence. This study will incorporate self-administration procedures and a non-drug alternative reinforcer, which is hypothesized to reduce the reinforcing effects of cocaine.

Detailed description:

Arms:
arm 1: A low value reinforcer will be made available as an alternative to cocaine and placebo. arm 2: A medium value reinforcer will be made available as an alternative to cocaine and placebo. arm 3: A high value reinforcer will be made available as an alternative to cocaine and placebo.

Interventions: intervention 1: Cocaine intervention 2: Placebo
Intervention descriptions: intervention 1: Three active doses of cocaine will be made available for self-administration during experimental sessions. intervention 2: Placebo cocaine will be made available for self-administration during experimental sessions.

Protocol document: