Conditions: Allergic Rhinitis Due to House Dust Mite
Keywords: HDM allergic rhinitis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 355
Healthy volunteers: no

Brief summary:
The purpose of this study is to assess the effect of 3 doses of sublingual house dust mite (HDM) tablets versus placebo in the change from baseline of rhinitis total symptom score during the allergen chamber challenge before and after 6 months of treatment.

Detailed description:

Arms:
arm 1: 100 IR house dust mites allergen extract tablet arm 2: 300 IR house dust mites allergen extract tablet arm 3: 500 IR house dust mites allergen extract tablet arm 4: Placebo tablet

Interventions: intervention 1: 100 IR house dust mites allergen extract tablet intervention 2: 300 IR house dust mites allergen extract tablet intervention 3: 500 IR house dust mites allergen extract tablet intervention 4: Placebo tablet
Intervention descriptions: intervention 1: One sublingual tablet daily during 6 months intervention 2: One sublingual tablet daily during 6 months intervention 3: One sublingual tablet daily during 6 months intervention 4: One sublingual tablet daily during 6 months

Protocol document: