Conditions: Pain
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 136
Healthy volunteers: no

Brief summary:
The purpose of this study is to compare the efficacy and safety of buprenorphine transdermal system to tramadol/acetaminophen.

Detailed description:

Arms:
arm 1: Patch arm 2: Oral tablet

Interventions: intervention 1: buprenorphine intervention 2: tramadol/acetaminophen
Intervention descriptions: intervention 1: Dosage and administration: This one patch should be attached every 7 days. intervention 2: Amount of drug ingredients

: Acetaminophen 325 mg and Tramadol hydrochloride 37.5 mg in 1 tablet of this drug.

Dosage and administration:

Adjust dose depending on a patient's pain severity and treatment response. Starting at the initial dose of 2 tablets, usually administer 4 tablets per dose, twice daily. At a dosing interval of at least 12 hr, the daily dose should not exceed 8 tablets.

Protocol document: