Conditions: Subarachnoid Hemorrhage
Keywords: subarachnoid hemorrhage vasospasm cerebral blood flow cerebral metabolism autoregulation statin Vasospasm associated with Subarachnoid hemorrhage
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 42
Healthy volunteers: no

Brief summary:
The primary objective of this project is to investigate the effect of statin therapy on cerebral blood flow in patients with aneurysmal SAH who are randomized to receive or not receive statins in a blinded design.

Detailed description:
We will determine if statin therapy improves CBF in patients with aneurysmal subarachnoid hemorrhage. This improvement, if present, may be due to improved basal CBF, improved autoregulatory function, or a mitigation of large arterial narrowing. The information gain from this study will help us to better understand the mechanism of action of statins. This knowledge may be useful in the design of future studies with statins and in the development of other therapies aimed at similar mechanisms.

Arms:
arm 1: Simvastatin, 80 mg/day for 21 days arm 2: Placebo

Interventions: intervention 1: Simvastatin, 80 mg/day for 21 days intervention 2: placebo
Intervention descriptions: intervention 1: Active treatment group intervention 2: Control group

Protocol document: