Conditions: Obesity
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 12
Healthy volunteers: yes

Brief summary:
If tigecycline clearance increases with body size then serum exposure values will be lower in obese class III compared to normal weight subjects because exposure changes inversely with clearance when the dose is fixed without regard to weight.

Detailed description:
Not required

Arms:
arm 1: All subjects receive a single dose of tigecycline

Interventions: intervention 1: Tigecycline
Intervention descriptions: intervention 1: 100 mg IV as a single infusion over 30 minutes

Protocol document: