Conditions: Complex Regional Pain Syndrome
Keywords: Complex Regional Pain Syndrome Pain management Ketamine infusion
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 3
Healthy volunteers: yes

Brief summary:
The purpose of this study is to determine whether epidural and ketamine infusions are effective in the treatment of Complex Regional Pain Syndrome (CRPS).

Detailed description:
Potential patients must clear all study requirements to be enrolled. Study requirements include labwork, psychiatric evaluation, and cardiology evaluation.

Once enrolled, patients will be in one of two groups:

1. Receives epidural infusion
2. Receives epidural and ketamine infusions

The patient and study staff are blinded.

This study requires multiple visits to Hospital for Special Surgery in New York City over the course of three months and concludes with a final visit after six months. The study will only cover costs associated with the scheduled in-patient and out-patient visits. The study patient will be responsible for all other costs (including travel and hotel accommodations) that he/she may incur for participating in this study.

Arms:
arm 1: Inpatient: Patients will receive a subanesthetic continuous intravenous infusion of KETAMINE 500mg/500ml in 0.9% Sodium Chloride with an epidural infusion.

Outpatient: Patients will receive three ketamine booster infusions over the course of three months. arm 2: Inpatient: Patients will receive a subanesthetic continuous intravenous infusion of SALINE 500mg/500ml in 0.9% Sodium Chloride with an epidural infusion.

Outpatient: Patients will receive three saline booster infusions over the course of three months.

Interventions: intervention 1: Ketamine Infusion + Epidural Infusion intervention 2: Control Group + Epidural infusion intervention 3: Ketamine Booster Infusion intervention 4: Control Group Booster Infusion
Intervention descriptions: intervention 1: The ketamine and epidural infusions will be administered over 96 hours with appropriate titration. intervention 2: The saline and epidural infusions will be administered over 96 hours with appropriate titration. intervention 3: Patients will receive three ketamine booster infusions over the course of three months. intervention 4: Patients will receive three saline booster infusions over the course of three months.

Protocol document: