Conditions: Knee Osteoarthritis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 194
Healthy volunteers: no

Brief summary:
The main purpose of this study is to compare the cartilage volume loss at the Baseline visit and after 24 months of treatment in patients treated with CHONDROITIN SULPHATE (CONDROSAN) 1200 mg daily vs. patients treated with CELECOXIB 200 mg daily.

Detailed description:
To compare long term disease modifiying and symptomatic effects at the Baseline visit and after 24 months of treatment in patients treated with CHONDROITIN SULPHATE 1200 mg daily vs. patients treated with CELECOXIB 200 mg daily.

Arms:
arm 1: CHONDROITIN SULPHATE Group: 1200 mg (three capsules of 400 mg each) taken once a day in the morning arm 2: CELECOXIB Group: 200 mg (one capsule of 200 mg CELECOXIB + two placebo capsules) taken in the morning

Interventions: intervention 1: Chondroitin sulfate intervention 2: Celecoxib
Intervention descriptions: intervention 1: Chondroitin sulphate 1200 mg/day, 24 months treatment period intervention 2: Celecoxib 200 mg/day, 24 months treatment period

Protocol document: