Conditions: Diabetes Mellitus, Type 2
Keywords: Type 2 diabetes safety multiple dose intravenous
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 50
Healthy volunteers: no

Brief summary:
This is a trial in subjects with Type 2 diabetes mellitus to study the safety, tolerability and pharmacokinetics of multiple ascending doses of PF-05231023.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: PF-05231023 intervention 2: PF-05231023 intervention 3: PF-05231023 intervention 4: PF-05231023 intervention 5: Placebo
Intervention descriptions: intervention 1: 5 mg IV twice a week for 4 weeks intervention 2: 25 mg IV twice a week for 4 weeks intervention 3: 100 mg IV twice a week for 4 weeks intervention 4: 200 mg IV twice a week for 4 weeks intervention 5: 0.9% w/v sodium chloride injection, United States Pharmacopeia (USP), twice a week IV for 4 weeks

Protocol document: