Conditions: Ocular Hypertension Open-angle Glaucoma
Keywords: Glaucoma
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 411
Healthy volunteers: no

Brief summary:
To evaluate the ocular hypotensive efficacy and ocular and systemic safety of AR-13324 Ophthalmic Solution, 0.02% compared to the active comparator Timolol maleate Ophthalmic Solution, 0.5%

Detailed description:

Arms:
arm 1: 1 drop AR-13324 in the evening (PM) \& 1 drop placebo in the morning (AM) in both eyes (OU) arm 2: 1 drop Timolol maleate twice daily (BID) in the morning (AM) \& evening (PM) in both eyes (OU)

Interventions: intervention 1: Timolol maleate Ophthalmic Solution 0.5% BID intervention 2: AR-13324 Ophthalmic Solution 0.02% intervention 3: Placebo
Intervention descriptions: intervention 1: 1 drop BID, AM/PM, OU intervention 2: 1 drop once daily (QD), PM, OU intervention 3: 1 drop QD, AM, OU

Protocol document: