Conditions: Coronary Artery Disease Diabetes Mellitus
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 42
Healthy volunteers: no

Brief summary:
CLOTILDIA is a single-center, prospective, randomized, open label, cross-over study evaluating the effects of ticagrelor versus high-dose clopidogrel on endothelial function and platelet reactivity in patients with type-2 diabetes mellitus (T2DM) treated with percutaneous coronary intervention (PCI).

Detailed description:

Arms:
arm 1: Ticagrelor 90 mg twice daily + standard medical therapy arm 2: Clopidogrel 150 mg once daily + standard medical therapy

Interventions: intervention 1: Ticagrelor intervention 2: Clopidogrel intervention 3: Standard medical therapy
Intervention descriptions: intervention 1: Ticagrelor 90 mg twice daily intervention 2: Clopidogrel 150 mg once daily intervention 3: Standard medical therapy for patients with coronary artery disease undergoing percutaneous coronary interventions

Protocol document: