Conditions: Open Angle Glaucoma Ocular Hypertension
Keywords: Open Angle Glaucoma Ocular Hypertension Intraocular Pressure
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 157
Healthy volunteers: no

Brief summary:
The purpose of this study is to demonstrate superior intraocular pressure (IOP) control with travoprost 0.004% / timolol 0.5% compared to beta-blocker monotherapy in participants with open-angle glaucoma or ocular hypertension.

Detailed description:

Arms:
arm 1: Travoprost 0.004% / timolol 0.5% fixed combination ophthalmic solution, 1 drop instilled in the study eye once daily (evening) for 8 weeks. arm 2: Participant's current beta-blocker monotherapy, 1 drop instilled in the study eye twice daily (morning and evening) for 4 weeks, followed by travoprost 0.004% / timolol 0.5% fixed combination ophthalmic solution, 1 drop instilled in the study eye once daily (evening) for 4 additional weeks.

Interventions: intervention 1: Beta-blocker monotherapy intervention 2: Travoprost 0.004% / timolol 0.5% fixed combination ophthalmic solution
Intervention descriptions: intervention 1: Per participant's current prescribed therapy intervention 2: None

Protocol document: