Conditions: Postoperative Nausea and Vomiting
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 88
Healthy volunteers: no

Brief summary:
The purpose of this study was to compare the antiemetic efficacy of aprepitant plus palonosetron versus aprepitant plus ramosetron in high risk patients undergoing laparoscopic cholecystectomy.

Detailed description:
The purpose of this study was to compare the antiemetic efficacy of aprepitant plus palonosetron versus aprepitant plus ramosetron in high risk patients undergoing laparoscopic cholecystectomy.

Study is performed during 24 hours after surgery.

Arms:
arm 1: aprepitant 80 mg palonosetron 0.075 mg arm 2: aprepitant 80 mg ramosetron 0.3 mg

Interventions: intervention 1: aprepitant intervention 2: palonosetron intervention 3: Ramosetron
Intervention descriptions: intervention 1: aprepitant 80 mg is given to all patients before surgery intervention 2: palonosetron 0.075 mg is given to patients in the aprepitant plus palonosetron group after induction of general anesthesia intervention 3: ramosetron 0.3 mg is given to patients in the aprepitant plus ramosetron group after induction of general anesthesia

Protocol document: