Conditions: Pre-diabetes
Keywords: pre-diabetes hydroxychloroquine frequently sampled intravenous glucose tolerance testing insulin resistance insulin secretion glucose tolerance
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 32
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine the short-term effects of the antimalarial medication, hydroxychloroquine (HCQ), compared with placebo using frequently sampled intravenous glucose tolerance testing (FSIGTT) methodology to study changes in insulin secretion and glucose tolerance in subjects at risk for developing Type 2 diabetes.

Detailed description:
Diabetes is approaching epidemic proportions in the United States. This study evaluates the mechanisms of action of a generic drug that may have effects on glucose metabolism.

Arms:
arm 1: Thirteen weeks of daily hydroxychloroquine following FSIGTT testing arm 2: Thirteen weeks of daily placebo following FSIGTT testing

Interventions: intervention 1: hydroxychloroquine intervention 2: Placebo
Intervention descriptions: intervention 1: Thirteen weeks of oral hydroxychloroquine (400 mg/day) provided as capsules intervention 2: Thirteen weeks of oral placebo provided as capsules

Protocol document: