Conditions: Opioid-Induced Constipation (OIC)
Keywords: Non-Cancer-Related Pain, Opioid-Induced Constipation
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 652
Healthy volunteers: no

Brief summary:
The purpose of this study is to evaluate the effect and safety of NKTR-118 treatment of opioid-induced constipation in patients with non-cancer-related pain, including those patients that have inadequate response to laxative therapy (LIR).

Detailed description:

Arms:
arm 1: Oral treatment arm 2: Oral treatment arm 3: Oral treatment

Interventions: intervention 1: NKTR-118 intervention 2: NKTR-118 intervention 3: Placebo
Intervention descriptions: intervention 1: 12.5 mg oral tablet once daily intervention 2: 25 mg oral tablet once daily intervention 3: Oral tablet once daily

Protocol document: