Conditions: Acne Vulgaris
Keywords: acne vulgaris inflammatory lesions
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 662
Healthy volunteers: no

Brief summary:
The primary objectives of the study is to show CD2475/101 40mg tablets taken once a day for 16 weeks is superior to the placebo in Change from baseline to Week 16(Last Observation Carry Forward, Intent To Treat) in inflammatory lesion counts.

Detailed description:
Investigator's global assessment and lesion count will be performed at each study visit.

Arms:
arm 1: Participants receive 40 mg of CD2475/101 oral tablet plus placebo capsule orally once daily for 16 weeks. arm 2: Participants receive 100 mg of Doxycycline capsule plus placebo tablet orally once daily for 16 weeks. arm 3: Participants receive matching placebo tablet plus placebo capsule orally once daily for 16 weeks.

Interventions: intervention 1: CD2475/101 40 mg intervention 2: Doxycycline 100 mg intervention 3: Placebo
Intervention descriptions: intervention 1: Participants receive 40 mg of CD2475/101 tablets once a day for 16 weeks. intervention 2: Participants receive 100 mg of Doxycycline capsule once a day for 16 weeks intervention 3: Participants receive matching placebo tablet, matching placebo capsule once a day for 16 weeks.

Protocol document: