Conditions: Diastolic Heart Failure Heart Failure, Congestive
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 80
Healthy volunteers: no

Brief summary:
The purpose of this study is to examine whether spironolactone will improve exercise tolerance and quality of life in elderly patients with heart failure preserved ejection fraction (HFPEF).

Detailed description:
Exercise intolerance due to HFPEF is a major cause of disability among older Americans. Several lines of evidence suggest that aldosterone antagonism may improve exercise tolerance in HFPEF. Therefore, the primary aim of this study is to test the hypothesis that spironolactone will improve exercise tolerance and quality of life in elderly patients with isolated HFPEF. A total of 72 participants aged 60 or older will be randomized to receive either spironolactone 25mg daily or a placebo.

Arms:
arm 1: Spironolactone arm 2: Placebo

Interventions: intervention 1: Spironolactone intervention 2: Placebo
Intervention descriptions: intervention 1: 25mg tablet daily for 9 months intervention 2: Placebo tablet daily for 9 months

Protocol document: