Conditions: Alzheimer's Disease
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 20
Healthy volunteers: yes

Brief summary:
The purpose of this study is to evaluate radiolabeled \[18F\]MK-3328 as a PET tracer for estimating the regional distribution and extent of amyloid plaques in participants suffering from amnestic mild cognitive impairment (aMCI) and Alzheimer's Disease (AD) versus healthy young and elderly participants. The study hypotheses will test whether \[18F\]MK-3328 can discriminate between AD participants and cognitively normal elderly control participants as measured by brain regional tracer uptake.

Detailed description:

Arms:
arm 1: HE and AD participants will receive a single intravenous (IV) dose of \~150 megabecquerel (MBq) \[18F\]MK-3328 in Part I of the study arm 2: Healthy Young, HE and AD participants will receive a single IV dose of \~150 megabecquerel (MBq) \[18F\]MK-3328 in Part II of the study arm 3: Participants with aMCI will receive a single IV dose of \~150 megabecquerel (MBq) \[18F\]MK-3328 in Part III of the study

Interventions: intervention 1: [18F]MK-3328
Intervention descriptions: intervention 1: IV dose of \~150 megabecquerel (MBq) \[18F\]MK-3328

Protocol document: