Conditions: Asthma
Keywords: Amgen AMG 157 Asthma
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 31
Healthy volunteers: no

Brief summary:
The purpose of this study is to assess the late and early asthmatic response after an allergen inhalation challenge in adults with mild atopic asthma after receiving multiple doses of tezepelumab (AMG 157), as well as the safety, tolerability, immunogenicity, and pharmacokinetics of multiple doses of tezepelumab in adults with mild atopic asthma.

Detailed description:

Arms:
arm 1: Participants received placebo to tezepelumab administered by intravenous infusion on study days 1, 29, and 57. arm 2: Participants received 700 mg tezepelumab administered by intravenous infusion on study days 1, 29, and 57.

Interventions: intervention 1: Placebo intervention 2: Tezepelumab
Intervention descriptions: intervention 1: Administered in a 1-hour intravenous infusion intervention 2: Administered in a 1-hour intravenous infusion

Protocol document: