Conditions: Attention Deficit Hyperactivity Disorder
Keywords: ADHD ADRA2A Methylphenidate Response
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 83
Healthy volunteers: yes

Brief summary:
The aims of the current study are to examine gene-environment interactions associated with norepinephrine (NE) system genes (ADRA2A, SLC6A2) in ADHD, and to evaluate whether genetic changes in norepinephrine pathway are associated with differences in functional connectivity of white matter fiber tracts, as measured by diffusion tensor imaging (DTI). Furthermore, this study aims to examine neurobiological markers, such as intermediate neuroimaging phenotypes or neuropsychological endophenotypes associated with the pathophysiology of ADHD. Through evaluating drug responses and side effects with the associated measures of clinical, neuropsychological and neuroimaging characteristics, investigators would like to investigate predictors of treatment response associated with NE system genes in ADHD.

Detailed description:

Arms:
arm 1: Participants were treated with methylphenidate (ranging from to 63mg) for 8 weeks. Doses of methylphenidate were titrated depending on symptoms and adverse eff ects at the 2nd and 4th weeks of treatment.

Interventions: intervention 1: Methylphenidate
Intervention descriptions: intervention 1: None

Protocol document: