Conditions: Neuropathic Pain Reflex Sympathetic Dystrophy Peripheral Neuropathy Post-herpetic Neuralgia Spinal Cord Injury Multiple Sclerosis
Keywords: cannabis marijuana neuropathy antinociception mood cognition neuropathic pain
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 44
Healthy volunteers: no

Brief summary:
This study theorized that a low dose of vaporized cannabis could alleviate nerve injury pain.

Detailed description:
We conducted a double-blind, placebo-controlled, crossover study evaluating the analgesic efficacy of vaporized cannabis in subjects, the majority of whom were experiencing neuropathic pain despite traditional treatment. Thirty-nine patients with central and peripheral neuropathic pain underwent a standardized procedure for inhaling medium-dose (3.53%), low-dose (1.29%), or placebo cannabis with the primary outcome being visual analog scale pain intensity. Psychoactive side effects and neuropsychological performance were also evaluated.

Arms:
arm 1: 3.53% THC by weight arm 2: 1.29% THC by weight arm 3: placebo marijuana

Interventions: intervention 1: Mild dose cannabis intervention 2: Low dose cannabis intervention 3: Cannabis
Intervention descriptions: intervention 1: 3.53% THC by weight intervention 2: 1.29% THC by weight intervention 3: 0.00% THC by weight

Protocol document: