Conditions: Parkinson Disease
Keywords: Parkinson Disease BIA 9-1067
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 105
Healthy volunteers: yes

Brief summary:
To assess the pharmacokinetics of BIA 9-1067 in healthy Japanese subjects

Detailed description:
Randomized, double-blind, placebo-controlled, multiple ascending dose, parallel-group, pharmacokinetic (PK) and pharmacodynamic (PD) study

Arms:
arm 1: OPC, opicapone, BIA 9-1067 arm 2: OPC, opicapone, BIA 9-1067 arm 3: OPC, opicapone, BIA 9-1067 arm 4: Placebo, PLC arm 5: OPC, opicapone, BIA 9-1067 arm 6: OPC, opicapone, BIA 9-1067 arm 7: OPC, opicapone, BIA 9-1067 arm 8: Placebo, PLC

Interventions: intervention 1: BIA 9-1067 intervention 2: Placebo
Intervention descriptions: intervention 1: 5 mg, 25 mg, and 50 mg of BIA 9-1067 (once-daily). intervention 2: once-daily

Protocol document: