Conditions: Coronary Artery Disease (CAD)
Keywords: pharmacologic stress Coronary Artery Disease (CAD) regadenoson ischemia
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 124
Healthy volunteers: no

Brief summary:
The purpose of this study is to compare Multidetector Computed Tomography (MDCT) and Single Photon Emission Computed Tomography (SPECT) stress myocardial perfusion imaging (MPI) with regadenoson in order to detect the presence or absence of reversible defects.

Detailed description:
All participants will be randomized to one of two imaging sequences: rest/stress SPECT on Day 1 followed by stress/rest MDCT on Day 2 or stress/rest MDCT on Day 1 followed by rest/stress SPECT on Day 2. All stress scans will involve the injection of regadenoson as the pharmacologic stress agent.

Arms:
arm 1: Resting SPECT imaging was performed prior to regadenoson stress SPECT

imaging. Imaging was conducted with one of two radiotracers (99mTc sestamibi or tetrofosmin). Regadenoson 0.4 mg was administered prior to stress SPECT as a single bolus injection. arm 2: Multidetector Computed Tomography (MDCT), composed of CCTA and regadenoson CTP. Regadenoson stress CTP was performed prior to rest CCTA/CTP imaging. Regadenoson 0.4 mg was administered prior to stress CTP as a single bolus injection. The rest CCTA/CTP was performed at least 30 minutes after completion of the stress CTP, after resolution of any symptoms brought on by the regadenoson infusion and after the participant's heart rate had returned to baseline.

Interventions: intervention 1: regadenoson intervention 2: technetium Tc99m sestamibi /technetium Tc99m tetrafosmin intervention 3: Contrast intervention 4: Single Photon Emission Computed Tomography intervention 5: Multidetector Computed Tomography
Intervention descriptions: intervention 1: Administered by intravenous bolus. intervention 2: Administered by intravenous infusion intervention 3: Administered by intravenous infusion. intervention 4: Procedure/Surgery intervention 5: Procedure/Surgery

Protocol document: