Conditions: Hypoparathyroidism
Keywords: PTH 1-84 Hypoparathyroidism NPSP558 Parathyroid Hormone 1-84
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 24
Healthy volunteers: no

Brief summary:
This study is designed to evaluate the effect of 6-months of treatment with NPSP558 in reducing requirements for supplemental oral calcium and active vitamin D, while maintaining stable total serum calcium levels in adult subjects with hypoparathyroidism.

Detailed description:
Subjects either must have previously completed NPSP558 Study CL1-11-040 (REPLACE) including 24 weeks of active therapy and 4 weeks of follow-up to Week 28 prior to enrolling in this study or have enrolled in REPLACE and dropped out during optimization, but currently meet inclusion/exclusion criteria for REPLACE.

Arms:
arm 1: None

Interventions: intervention 1: NPSP558
Intervention descriptions: intervention 1: 50, 75, 100 μg

Protocol document: