Conditions: Hematologic Malignancies
Keywords: Chronic Myeloid Leukemia Myelofibrosis Myelodysplastic Syndrome Acute myeloid Leukemia Hedgehog inhibitor
Allocation: NON_RANDOMIZED | Intervention model: SEQUENTIAL
Enrollment: 47
Healthy volunteers: no

Brief summary:
This study examines the effect of a small molecule inhibitor to the Sonic Hedgehog pathway on select hematologic malignancies.

Detailed description:

Arms:
arm 1: None

Interventions: intervention 1: PF-04449913
Intervention descriptions: intervention 1: Escalating doses of PF-04449913 administered as tablets PO QD continuously in 28 day cycles

Protocol document: