Conditions: Major Depressive Disorder
Keywords: ketamine depression treatment resistance intranasal, antidepressant glutamate NMDA receptor
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 20
Healthy volunteers: no

Brief summary:
The objective of the current study is to investigate the safety and efficacy of a single dose of intranasal (IN) ketamine in treatment-resistant depression (TRD).

Detailed description:

Arms:
arm 1: Subjects randomized to this arm will receive the active study medication, intranasal ketamine. arm 2: Subjects randomized to this arm will receive intranasal saline.

Interventions: intervention 1: Ketamine intervention 2: placebo
Intervention descriptions: intervention 1: A single dose of intranasal ketamine up to 50 mg intervention 2: Single dose of saline intranasal

Protocol document: