Conditions: Psoriasis Vulgaris Psoriasis
Keywords: plaque psoriasis vulgaris topical treatment skin diseases papulosquamous Tofacitinib CP-690550 Xeljanz psoriasis moderate severe itch nail psoriasis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 476
Healthy volunteers: no

Brief summary:
The study is beng done to test if tofacitinib ointment is safe and effective for people with plaque psoriasis. Two dose strengths of tofacitinib ointment (20 mg/g and 10 mg/g) applied once or twice daily are being tested. The safety and effectiveness of tofacitinib ointment used for 12 weeks will be compared to the safety and effectiveness of placebo ointment (vehicle) used for 12 weeks.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None arm 4: None arm 5: None arm 6: None

Interventions: intervention 1: tofacitinib ointment 20 mg/g intervention 2: tofacitinib ointment 10 mg/g intervention 3: placebo ointment (vehicle) intervention 4: tofacitinib ointment 20 mg/g intervention 5: tofacitinib ointment 10 mg/g intervention 6: placebo ointment (vehicle)
Intervention descriptions: intervention 1: tofacitinib ointment 20 mg/g BID (twice daily) for 12 weeks intervention 2: tofacitinib ointment 10 mg/g BID (twice daily) for 12 weeks intervention 3: placebo ointment (vehicle) BID (twice daily) for 12 weeks intervention 4: tofacitinib ointment 20 mg/g QD (once daily) for 12 weeks intervention 5: tofacitinib ointment 10 mg/g QD (once daily) for 12 weeks intervention 6: placebo ointment (vehicle) QD (once daily) for 12 weeks

Protocol document: