Conditions: Type 2 Diabetes Coronary Heart Disease
Keywords: diastolic function mitochondria pioglitazone pericardial fat
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 130
Healthy volunteers: yes

Brief summary:
The purpose of this study is to examine the existence of heart abnormalities in patients with diabetes and the effect of pioglitazone in correcting these abnormalities.

Detailed description:
PRIMARY OBJECTIVES

1. To quantitate myocardial insulin sensitivity using positron emission tomography (PET) with 18F-deoxyglucose in type 2 diabetes mellitus (T2DM) and control subjects.
2. To quantitate pericardial fat using magnetic resonance spectroscopy in T2DM and control subjects.
3. To quantitate cardiac function using magnetic resonance imaging and echocardiography in T2DM and control subjects.
4. To examine the effect of pioglitazone on myocardial insulin sensitivity, pericardial fat content, and cardiac function.

SECONDARY OBJECTIVES To examine the relationships between myocardial insulin sensitivity, pericardial fat content, and cardiac function.

Arms:
arm 1: Only subjects with T2DM or non-diabetic subjects with coronary heart disease will receive Pioglitazone

Interventions: intervention 1: pioglitazone
Intervention descriptions: intervention 1: 45 mg per day for 6 months

Protocol document: