Conditions: Peptic Ulcer
Keywords: proton pump inhibitor peptic ulcer clopidogrel prevention
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 165
Healthy volunteers: no

Brief summary:
Proton Pump Inhibitors (PPI) can prevent the recurrence of peptic ulcer in clopidogrel users.

Detailed description:
The aim of the prospective, randomized study is to investigate the efficacy of PPI in prevention of ulcer recurrence for clopidogrel users. We plan to enroll 300 clopidogrel users without baseline gastroduodenal ulcer at initial endoscopy. The patients will be randomly assigned to receive either (1) esomeprazole (20 mg qd) plus clopidogrel or (2) clopidogrel treatment alone for 6 months. The ulcer recurrence rate between the treatment groups will be compared.

Arms:
arm 1: esomeprazole (20 mg qd) plus clopidogrel (75 mg qd) for 6 months arm 2: clopidogrel 75 mg qd for 6 months

Interventions: intervention 1: esomeprazole
Intervention descriptions: intervention 1: esomeprazole 20 mg qd for 6 months

Protocol document: