Conditions: Primary Osteoarthritis of Knee Nos
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 152
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine 1) the effective dosage of intra-articular tranexamic acid injection for controlling blood loss and blood transfusion requirement in conventional total knee replacement, and 2) whether the blood loss reduction effect depended on the dose of tranexamic acid used.

Detailed description:

Arms:
arm 1: physiologic saline 25 ml arm 2: A total of 25-ml solution with 250-mg tranexamic acid arm 3: A total of 25-ml solution with 500-mg tranexamic acid

Interventions: intervention 1: Tranexamic Acid intervention 2: Physiologic saline
Intervention descriptions: intervention 1: Inject tranexamic acid solution intra-articularly after fascia closure intervention 2: Use physiologic saline for mixing with tranexamic acid or use alone in placebo group

Protocol document: