Conditions: Physiological Function in Low Oxygen Environment
Keywords: Hypoxia Altitude Exercise
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 41
Healthy volunteers: yes

Brief summary:
In low oxygen environments, such as altitude, some adults may become ill and suffer from acute mountain sickness. Further, all adults will find that exercising becomes much more difficult when compared with exercise at lower altitudes (e.g. sea-level). The purpose of this investigation is to study the effects of two drugs that may help people adjust to high-altitude quickly, prevent them from becoming ill and improve their exercise performance. The drugs are Methazolamide and Aminophylline.

Detailed description:

Arms:
arm 1: Administer a single dose of placebo (yellow corn meal in a capsule, gelatin ) in Normoxic Conditions.

Following a minimum of 7 days a single dose placebo will be administered (yellow corn meal in a gelatin capsule) in Hypoxic conditions. arm 2: Administer a single dose of 400 mg Aminophylline (4-100 mg tablets) in Normoxic Conditions.

Following a minimum of 7 days administer a single dose of 400 mg Aminophylline (4-100 mg tablets) in Hypoxic conditions. arm 3: Administer a single dose of 250 mg Methazolamide (10-25 mg tablets) in Normoxic Conditions.

Following a minimum of 7 days administer a single dose of 250 mg Methazolamide (10-25 mg tablets) in Hypoxic conditions. arm 4: Administer a single dose of 400 mg Aminophylline (4-100 mg tablets) + 250 mg Methazolamide (10-25 mg tablets) in Normoxic Conditions.(Aminophylline+Methazolamide)

Following a minimum of 7 days administer a single dose of 400 mg Aminophylline (4-100 mg tablets) + 250 mg Methazolamide (10-25 mg tablets) in Hypoxic conditions.

Interventions: intervention 1: Placebo intervention 2: Aminophylline intervention 3: Methazolamide intervention 4: Aminophylline+Methazolamide
Intervention descriptions: intervention 1: Yellow corn meal in gel capsules intervention 2: National Drug Code (NDC) 0143-1020-01 intervention 3: NDC 0781-1072-01 intervention 4: NDC 0143-1020-01 and NDC 0781-1072-01

Protocol document: