Conditions: Glaucoma
Keywords: failing blebs failing express shunt avastin bevacizumab glaucoma prior trabeculectomy Express shunt placed under a scleral flap subsequent filtration failure
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 63
Healthy volunteers: no

Brief summary:
The purpose of this study is to see if a new add on (or adjunctive) therapy used in glaucoma surgery improves the success of needle bleb revisions.

Detailed description:
To investigate the efficacy of needle bleb revisions with mitomycin C with subconjunctival bevacizumab in promoting both filtering success and favorable bleb morphologic features.

Arms:
arm 1: subjects will receive 1.0mg (0.04cc of 25 mg/ml) subconjunctival bevacizumab either temporal or nasal to the bleb following bleb needling procedure in addition to 0.1 cc mitomycin C. arm 2: patients randomized to treatment B are given 0.04cc of balanced salt solution injected in identical fashion either temporal or nasal to the bleb following bleb needling procedure in addition to 0.1 cc mitomycin C.

Interventions: intervention 1: bevacizumab intervention 2: balanced salt solution
Intervention descriptions: intervention 1: 1.0mg (0.04 cc of 25 mg/ml subconjunctival bevacizumab following bleb needling procedure intervention 2: 0.04 cc of balanced salt solution injected to the bleb following bleb needling procedure

Protocol document: