Conditions: Nephropathy
Keywords: prevention nephropathy
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 21
Healthy volunteers: yes

Brief summary:
To determine if statin therapy plus intravenous normal saline, in patients with chronic renal insufficiency undergoing angiography, is superior to placebo plus intravenous normal saline therapy in the prevention of CIN.

Detailed description:
Due to the conflict in the available data, there are no practice guidelines that are established in order to prevent contrast-induced nephropathy (CIN). Our goal is to determine if statin therapy plus intravenous normal saline, in patients with chronic renal insufficiency undergoing angiography, is superior to placebo plus intravenous normal saline therapy in the prevention of CIN.

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: placebo intervention 2: atorvastatin
Intervention descriptions: intervention 1: pre-treatment with placebo (80 mg 12 hours prior to the procedure and 40 mg pre-procedure) intervention 2: pre-treatment with atorvastatin (80 mg 12 hours prior to the procedure and 40 mg pre-procedure)

Protocol document: