Conditions: Neoplasms Breast Neoplasms Breast Cancer
Keywords: Cancer tumour breast cancer metastatic secondary locally advanced
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 482
Healthy volunteers: no

Brief summary:
The main purpose of this study is to compare progression free survival in patients treated with AZD8931 given in combination with anastrozole versus anastrozole alone. The secondary objective is to investigate the safety and tolerability of AZD8931 given in combination with anastrozole.

Detailed description:

Arms:
arm 1: AZD8931 40mg (bd) plus anastrozole 1mg (od) arm 2: AZD8931 20mg (bd) plus anastrozole 1mg (od) arm 3: Placebo (bd) plus anastrozole 1mg (od)

Interventions: intervention 1: AZD8931 intervention 2: anastrozole intervention 3: Placebo
Intervention descriptions: intervention 1: Tablet, oral, bd intervention 2: Tablet, oral, od intervention 3: Tablet, oral

Protocol document: