Conditions: Advanced Parkinson's Disease
Keywords: Rotigotine Neupro® Levodopa Gastrointestinal Dysfunction
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 25
Healthy volunteers: no

Brief summary:
The primary purpose is to demonstrate superiority of Rotigotine over Placebo on motor symptoms when used in subjects with symptoms of Gastrointestinal Dysfunction. Hypothesis: Rotigotine will decrease OFF time compared to Placebo.

Detailed description:

Arms:
arm 1: Rotigotine patch titrated from 4 mg/24 h - 8 mg/24 h or until effective or maximum dose is reached. arm 2: Placebo patch.

Interventions: intervention 1: Rotigotine intervention 2: Placebo
Intervention descriptions: intervention 1: Strength and Form: 4 - 8 mg patches, one patch applied every 24 hours

Dosage and Frequency: One patch every 24 hours

Duration: 10 weeks intervention 2: Frequency: One patch applied every 24 hours

Duration: 10 weeks

Protocol document: