Conditions: Allergic Rhinitis
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 14
Healthy volunteers: yes

Brief summary:
The objectives of this protocol are:

1. to confirm the inhibitory effect of Nasaleze on the immediate response to nasal challenge with antigen, and
2. to show that inhibition of the immediate response to nasal challenge with antigen by Nasaleze inhibits subsequent inflammatory events.

Detailed description:

Arms:
arm 1: Nasaleze spray 1 puff via "spray device" in each nostril 3 times daily for 1 week followed by allergen challenge arm 2: Placebo spray 1 puff via "spray device" in each nostril 3 times daily for 1 week followed by allergen challenge

Interventions: intervention 1: Nasaleze Spray intervention 2: Placebo spray intervention 3: Allergen
Intervention descriptions: intervention 1: Subjects are treated with over the counter Nasaleze cellulose powder nasal spray then challenged with allergen intervention 2: Subjects are treated with placebo nasal spray then challenged with allergen intervention 3: Subjects are challenged with grass or ragweed allergen after treatment with Nasaleze or placebo

Protocol document: