Conditions: Alloimmune Thrombocytopenia Fetal Alloimmune Thrombocytopenia
Keywords: Alloimmune thrombocytopenia Fetal alloimmune thrombocytopenia
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 102
Healthy volunteers: no

Brief summary:
The purposes of this study are to provide medical management by giving treatment to the mother that will bring up the fetal platelet count and to minimize the number of invasive procedures to the fetus (which may result in serious fetal injuries).

Detailed description:

Arms:
arm 1: IVIG 2 g/kg/wk divided into 2 infusions per week for women with a fetus affected by FNAIT arm 2: IVIG 1 g/kg/wk in 1 infusion per week + prednisone 0.5 mg po daily for women with a fetus affected by FNAIT

Interventions: intervention 1: IVIG (Intravenous Immunoglobulin) intervention 2: prednisone
Intervention descriptions: intervention 1: one gram per kg of IVIG per infusion given either once or twice intervention 2: in arm with IVIG 1 gm/kg/wk will also receive prednisone 0.5 mg/kg/day

Protocol document: