Conditions: Healthy Volunteers
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 62
Healthy volunteers: yes

Brief summary:
The main purpose of this study is to investigate how the body responds to evacetrapib and to evaluate the safety and the effect of evacetrapib, alone and in combination with selected statins, in healthy Chinese participants. The study has 2 parts. Part one will last up to 4 weeks and part two will last up to 5 weeks, not including screening. Participants may only enroll in one part.

Detailed description:

Arms:
arm 1: Part 1, Cohort A, Period 1, Participants will receive a single oral 130 mg dose of evacetrapib. arm 2: Part 1, Cohort A, Period 2, Participants will receive multiple doses of evacetrapib for 14 days. arm 3: Part 2, Cohorts B, Participants will receive simvastatin orally, once daily on Days 1 - 4. arm 4: Part 2, Cohorts B, Participants will receive evacetrapib orally once daily on Days 5 - 14 and simvastatin orally, once daily on Days 15 - 22. arm 5: Part 2, Cohorts C, Participants will receive atorvastatin orally, once daily on Days 1 - 4. arm 6: Part 2, Cohorts C, Participants will receive evacetrapib orally once daily on Days 5 - 14 and atorvastatin orally, once daily on Days 15 - 22.

Interventions: intervention 1: Evacetrapib intervention 2: Simvastatin intervention 3: Atorvastatin
Intervention descriptions: intervention 1: Administered orally. intervention 2: Administered orally. intervention 3: Administered orally.

Protocol document: