Conditions: Hypogonadism Osteopenia Osteoporosis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 44
Healthy volunteers: yes

Brief summary:
This study will investigate the hypothesis that the combination of testosterone replacement and alendronate will improve bone density and parameters of bone quality more than either medication alone in older men with low testosterone levels and low bone density.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None

Interventions: intervention 1: Testosterone intervention 2: Alendronate intervention 3: Placebo Alendronate intervention 4: Placebo Testosterone
Intervention descriptions: intervention 1: Testosterone Gel (Fortesta) 40mg daily. intervention 2: Alendronate (Fosamax) 70mg every week. intervention 3: A placebo alendronate tablet will be taken every week by subjects in the Testosterone and Placebo Alendronate Group. intervention 4: Placebo testosterone gel will be applied daily by subjects in the Alendronate and Placebo Testosterone group.

Protocol document: