Conditions: Cocaine Use Disorders
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 9
Healthy volunteers: yes

Brief summary:
Cocaine use disorders are an unrelenting public health concern. Intensive research efforts have yielded behavioral interventions that reduce cocaine use, however, these interventions are not universally effective and treatment effects diminish over time. Development of a pharmacotherapy that enhances the efficacy of these interventions is a priority for the National Institute on Drug Abuse. This study proposes to determine the impact of buspirone maintenance on self-administration of cocaine and alternative reinforcers. These preliminary data will be used to support further research developing buspirone as a pharmacotherapy for cocaine use disorders. We hypothesize that buspirone will attenuate the reinforcing effects of cocaine and increase the reinforcing effects of alternative reinforcers.

Detailed description:

Arms:
arm 1: Subjects will be maintained on 30 mg buspirone daily. arm 2: Subjects will be maintained on placebo (i.e., 0 mg buspirone daily).

Interventions: intervention 1: Buspirone intervention 2: Placebo
Intervention descriptions: intervention 1: Subjects will be maintained on oral buspirone (10 mg administered 3 times daily) for 6 days each during the study in random order. intervention 2: Subjects will be maintained on oral placebo (0 mg administered 3 times daily) for 6 days each during the study in random order.

Protocol document: