Conditions: Type 2 Diabetes
Keywords: Dapagliflozin efficacy safety metformin Type 2 diabetes
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 1217
Healthy volunteers: no

Brief summary:
This study is being carried out to see if dapagliflozin as an addition to metformin is effective and safe in treating patients with type 2 diabetes when compared to glipizide (sulphonylurea) as an addition to metformin treatment.

Detailed description:

Arms:
arm 1: dapagliflozin plus metformin arm 2: glipizide plus metformin

Interventions: intervention 1: dapagliflozin intervention 2: glipizide intervention 3: metformin hydrochloride
Intervention descriptions: intervention 1: Tablet oral 2.5, 5, or 10 mg total daily dose once daily 208 weeks intervention 2: Capsule oral 5, 10, or 20 mg total daily dose once or split/twice daily 208 weeks intervention 3: Tablet oral 1500, 2000, or 2500 mg total daily dose split/twice daily 218 weeks

Protocol document: