Conditions: Psoriasis
Keywords: Palmo-Plantar Pustolosis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 33
Healthy volunteers: no

Brief summary:
The main purpose of this study is to demonstrate the improvement in the skin condition rate of patients receiving alitretinoin compared to patients receiving placebo.

Detailed description:
Palmo-plantar pustulosis (PPP) is an inflammatory skin disease affecting palms and soles. The disease is considered as a sub-form of psoriasis and presents with sterile pustules of the palms and the soles. This study investigates the efficacy of alitretinoin in patients who have not responded to topical drugs (e.g., steroid creams), who are suffering for at least 6 month from the condition and whose disease severity is confirmed by a score.

Arms:
arm 1: to receive study drug (alitretinoin, 20 patients) arm 2: to receive placebo (dummy drug, 10 patients)

Interventions: intervention 1: alitretinoin intervention 2: Placebo
Intervention descriptions: intervention 1: to receive verum (20 patients) intervention 2: to receive placebo (10 patients)

Protocol document: