Conditions: Healthy Volunteers
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 18
Healthy volunteers: yes

Brief summary:
The purposes of this study are to look at what effect multiple doses of rifampicin have on a single dose of baricitinib and to look at the safety and tolerability of these drugs. Side effects will be documented. The study will last approximately 31 days from the first dose to the end of the study.

Detailed description:

Arms:
arm 1: Single oral dose of 10 milligrams (mg) baricitinib on Day 1. arm 2: Oral doses of 600 mg rifampicin once daily on Days 3 to 11, with a single oral dose of 10 mg baricitinib co-administered on Day 10.

Interventions: intervention 1: Baricitinib intervention 2: Rifampicin
Intervention descriptions: intervention 1: Administered orally intervention 2: Administered orally

Protocol document: