Conditions: Stomach Neoplasms
Keywords: chemotherapy combination
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 27
Healthy volunteers: no

Brief summary:
To assess the maximal tolerated dose (MTD) and overall safety of sunitinib when administered in combination with S-1 and Cisplatin in patients with advanced/metastatic gastric cancer.

Detailed description:

Arms:
arm 1: None

Interventions: intervention 1: Cisplatin intervention 2: S-1 intervention 3: Sunitinib
Intervention descriptions: intervention 1: Cisplatin 60 mg/m2 on day 1 of each 28 day cycle intervention 2: S-1 80 mg/m2 on days 1-21 of each 28 day cycle intervention 3: Sunitinib 25 mg, 37.5 mg and 50 mg daily S-1 80 mg/m2 on days 1-21 of each 28 day cycle Cisplatin 60 mg/m2 on day 1 of each 28 day cycle

Protocol document: