Conditions: Advanced Hematologic Malignancies Leukemia Preleukemia
Keywords: Melphalan Alemtuzumab Clofarabine
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 82
Healthy volunteers: no

Brief summary:
This is a clinical research study designed to evaluate whether a conditioning regimen consisting of the combination of three drugs named melphalan, alemtuzumab and clofarabine supported by donor blood cells will result in rapid recovery and a high rate of long-lasting remissions in patients with leukemia, lymphoma and myeloma.

Detailed description:

Arms:
arm 1: None

Interventions: intervention 1: Clofarabine intervention 2: Melphalan intervention 3: Campath intervention 4: Stem Cell Transplant
Intervention descriptions: intervention 1: Clofarabine will be administered as a 2-hour IV infusion on Days 1 through 5 at approximately the same time everyday (4 dose levels). intervention 2: Doses ranging from 100 to 140 mg/m2 intervention 3: 20mg/d x5 intervention 4: Infusion of donor, bone marrow and auto.

Protocol document: