Conditions: Coughing
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 141
Healthy volunteers: no

Brief summary:
Coughing during emergence from general anaesthesia may lead to dangerous effects including laryngospasm, detrimental haemodynamic changes. Post-thyroidectomy bleeding occurs in 1-4% of patients, and severe coughing may cause bleeding. Dexmedetomidine, a potent α adrenoreceptor agonist, is theoretically appropriate for reducing airway and haemodynamic reflexes during emergence from anaesthesia.

In this study, we investigated whether intravenous single-dose dexmedetomidine at the end of surgery reduces coughing during extubation after thyroidectomy.

Detailed description:

Arms:
arm 1: We administrate the dexmedetomidine single bolus (0.5ug/kg, intravenously, for 10 min) at time of muscle layer closing. arm 2: We administrate the saline single bolus (0.25ml/kg,intravenously, for 10 min) at time of muscle layer closing.

Interventions: intervention 1: Dexmedetomidine intervention 2: Saline
Intervention descriptions: intervention 1: We administrate the dexmedetomidine single bolus (0.5ug/kg, intravenously) at time of muscle layer closing. intervention 2: We administrate the normal saline (single bolus, 0.25ml/kg) intravenously at time of muscle layer closing.

Protocol document: