Conditions: Essential Hypertension
Keywords: hypertension blood pressure LCZ696 dual-acting neprilysin nep inhibitor vasopeptidase angiotensin receptor angiotensin receptor neprilysin inhibitor (ARNi)
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 341
Healthy volunteers: no

Brief summary:
The purpose of this study is to assess the long-term safety, tolerability and efficacy of LCZ696.

Detailed description:

Arms:
arm 1: None

Interventions: intervention 1: LCZ696 intervention 2: Amlodipine intervention 3: Hydrochlorothiazide (HCTZ)
Intervention descriptions: intervention 1: Participants received LCZ696 200 mg as the starting dose with optional down titration to 100 mg for tolerance and optional up titration to 400 mg for adequate blood pressure control. intervention 2: Optional add-on of amlodipine (5-10 mg) was allowed (as applicable per local country regulations) for adequate blood pressure control. intervention 3: Optional add-on of hydrochlorothiazide (HCTZ) (12.5-25 mg) was allowed (as applicable per local country regulations) for adequate blood pressure control.

Protocol document: