Conditions: Healthy Volunteer
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 24
Healthy volunteers: yes

Brief summary:
This single center, open-label, 3-period, fixed-sequence study will evaluate the effect of multiple oral doses of rifampin on the pharmacokinetics of a single oral dose of RO5424802 in healthy volunteers. Subjects will receive a single dose of RO5424802 on Days 1 and 17 and rifampin daily from Days 8 to Day 20.

Detailed description:

Arms:
arm 1: None

Interventions: intervention 1: RO5424802 intervention 2: rifampin
Intervention descriptions: intervention 1: Single dose without (Day 1) and with (Day 17) co-administration of rifampin intervention 2: Multiple doses Days 8-16 and Days 17-20

Protocol document: