Conditions: Heart Failure (HF) Ventricular Dysfunction, Left
Keywords: Nuclear imaging Radiopharmaceutical Iobenguane I-123 reproducibility Quantitative measurements myocardial uptake SPECT imaging planar imaging AdreView™
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 63
Healthy volunteers: no

Brief summary:
The aim of the study was to assess the reproducibility of quantitative measurements of myocardial uptake of Iobenguane I 123 on planar and single photon emission computed tomography (SPECT) imaging following intravenous (i.v.) administration of AdreView. Efficacy was assessed based upon the absolute differences between quantitative analyses of imaging data on 2 scans performed 5 to 14 days apart.

Detailed description:

Arms:
arm 1: Two administrations of single intravenous (i.v) injection of Iobenguane I 123 10 millicuries (mCi) (370 MBq) over 1 to 2 minutes within an interval of 5 to 14 days.

Interventions: intervention 1: AdreView (Iobenguane I 123 Injection)
Intervention descriptions: intervention 1: AdreView 10 mCi as a single i.v administration

Protocol document: