Conditions: Cellulitis
Keywords: Cellulitis Bactrim Trimethoprim Sulfamethoxazole MRSA Methicillin-resistant Staphylococcus aureus
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 153
Healthy volunteers: no

Brief summary:
The primary aim of this study is to quantify the effectiveness of Bactrim as additional therapy for the treatment of uncomplicated cellulitis in adults, by comparing: standard therapy plus Bactrim, versus standard therapy plus placebo.

The primary hypothesis of this study is that, in light of increasing CA-MRSA prevalence, subjects treated with standard therapy plus Bactrim will have higher cure rates than those treated with standard therapy plus placebo.

Detailed description:

Arms:
arm 1: cephalexin plus placebo arm 2: cephalexin plus trimethoprim-sulfamethoxazole

Interventions: intervention 1: trimethoprim-sulfamethoxazole intervention 2: Cephalexin
Intervention descriptions: intervention 1: Weight-based dosing in capsule or suspension form according to the following scale:

15-19 kg (33-42 lbs): trimethoprim-sulfamethoxazole 40/200 mg four times daily

20-24 kg (42-53 lbs): trimethoprim-sulfamethoxazole 60/300 mg four times daily

25-29 kg (53-64 lbs): trimethoprim-sulfamethoxazole 72/360 mg four times daily

29-60 kg (64-132 lbs): trimethoprim-sulfamethoxazole 80/400 mg four times daily

60 kg (132 lbs): trimethoprim-sulfamethoxazole 80/400 mg four times daily

60-80 kg (132-176 lbs): trimethoprim-sulfamethoxazole 160/800 mg three times daily

\> 80 kg (176 lbs): trimethoprim-sulfamethoxazole 160/800 mg four times daily intervention 2: Weight-based dosing in capsule or suspension form according to the following scale:

15-19 kg (33-42 lbs): Cephalexin 300 mg four times daily

20-24 kg (42-53 lbs): Cephalexin 400 mg four times daily

25-29 kg (53-64 lbs): Cephalexin 500 mg four times daily

29-60 kg (64-132 lbs): Cephalexin 500 mg four times daily

60-80 kg (132-176 lbs): Cephalexin 1000 mg three times daily

\> 80 kg (176 lbs): Cephalexin 1000 mg four times daily

Protocol document: