Conditions: Presbyopia
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 65
Healthy volunteers: no

Brief summary:
A study to evaluate the safety and efficacy of AGN-199201 alone, AGN-190584 alone and concurrent use of AGN-199201 and AGN-190584 in patients with presbyopia (inability to focus for near vision).

Detailed description:

Arms:
arm 1: 1 drop of AGN-199201 ophthalmic solution followed by 1 drop of AGN-199201 vehicle in the non-dominant eye and 2 drops of AGN-199201 vehicle in the dominant eye, once and twice daily for 3 days each. arm 2: 1 drop of AGN-190584 ophthalmic solution followed by 1 drop of AGN-199201 vehicle in the non-dominant eye and 2 drops of AGN-199201 vehicle in the dominant eye, once and twice daily for 3 days each. arm 3: 1 drop of AGN-199201 ophthalmic solution followed by 1 drop of AGN-190584 ophthalmic solution in the non-dominant eye and 2 drops of AGN-199201 vehicle in the dominant eye, once and twice daily for 3 days each. arm 4: 1 drop of AGN-199201 ophthalmic solution followed by 1 drop of AGN-190584 ophthalmic solution in both eyes, once and twice daily for 3 days each.

Interventions: intervention 1: AGN-199201 intervention 2: AGN-190584 intervention 3: AGN-199201 Vehicle
Intervention descriptions: intervention 1: 1 to 2 drops of AGN-199201 ophthalmic solution in the eye(s) as per protocol. intervention 2: 1 to 2 drops of AGN-190584 ophthalmic solution in the eye(s) as per protocol. intervention 3: 1 to 2 drops of AGN-199201 vehicle in the eye(s) as per protocol.

Protocol document: