Conditions: Healthy
Keywords: HSV Herpes volunteers drug-drug interaction
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 27
Healthy volunteers: yes

Brief summary:
CYP3A4 is involved in the metabolism of many drugs. So, it is important to assess in vivo the induction effect of ASP2151 on that enzyme to determine the extent of any possible drug interactions. The aim of this trial is to investigate the potential for interaction of ASP2151 with the CYP3A4 probe substrate midazolam.

Detailed description:

Arms:
arm 1: 400 mg ASP2151 followed by 7.5 mg midazolam

Interventions: intervention 1: Midazolam intervention 2: ASP2151
Intervention descriptions: intervention 1: None intervention 2: None

Protocol document: