Conditions: Healthy
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 18
Healthy volunteers: yes

Brief summary:
The objectives of the trial are to investigate the effect of concurrent administration of rifampicin and probenecid on the pharmacokinetics of empagliflozin.

Detailed description:

Arms:
arm 1: Empagliflozin (BI 10773), Film-coated tablet, single dose arm 2: Empagliflozin (BI 10773), Film-coated tablet, single dose, and Rifampicin,Film-coated tablet single dose arm 3: Empagliflozin (BI 10773), Film-coated tablet, single dose, and Probenecid Tablet twice daily

Interventions: intervention 1: Probenecid intervention 2: Rifampicin intervention 3: Empagliflozin intervention 4: Empagliflozin intervention 5: Rifampicin intervention 6: Probenecid intervention 7: Empagliflozin (BI 10773)
Intervention descriptions: intervention 1: Probenecid intervention 2: Rifampicin intervention 3: BI Drug intervention 4: BI Drug intervention 5: Rifampicin intervention 6: Probenecid intervention 7: BI Drug

Protocol document: