Conditions: Malaria
Keywords: Malaria, KAE609
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 25
Healthy volunteers: no

Brief summary:
This study aims to determine the Minimum Inhibitory Concentration of KAE609 in adult male patients with acute, uncomplicated malaria due to P.falciparum monoinfection after single dosing with KAE609

Detailed description:
There will be a total of approximately 45 patients recruited into this study and six doses of KAE609 and will be investigated.The dose groups will run in sequence. Patient will be given a single dose of KAE609 and be followed up for 42 days.

Arms:
arm 1: Single dose of KAE609 30 mg arm 2: Single dose of KAE609 20 mg arm 3: Single dose of KAE609 10 mg arm 4: Single dose of KAE609 15 mg

Interventions: intervention 1: KAE609
Intervention descriptions: intervention 1: Patients will receive KAE609 single dose at a different dose level in each cohort.

Protocol document: