Conditions: Depression Suicidal Ideation
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 18
Healthy volunteers: no

Brief summary:
This study is dedicated to achieving better treatments for suicidal thoughts. Specifically, the investigators are studying the effect of a medication called ketamine to quickly treat suicidal thoughts and depression.

Detailed description:
This study is dedicated to achieving better treatments for suicidal thoughts. Specifically, we are studying the effect of a medication called ketamine to quickly treat suicidal thoughts and depression. Patients will be asked to participate in a research study to study how the use of a medication, ketamine, decreases your suicidal thoughts and improves their symptoms of depression. Ketamine is approved by FDA for use at higher doses in anesthesia, and recent clinical research suggests that it might benefit patients with major depressive disorder and suicidal thoughts. During clinical trials with over 10,000 patients, ketamine was proved to be safe as an anesthetic and studies with hundreds of patients with depression have demonstrated safety and lack of lasting side effects. This is a pilot study to test a new use of ketamine: treatment of suicidal thoughts. The study medication will be given in addition to usual psychiatric care.

Arms:
arm 1: suicidal ideation and depression (no substance use disorder) 0.2 mg/kg IV ketamine administered as a one time dose arm 2: Suicidal ideation and depression (no substance use disorder) comparable amount of placebo (saline) arm 3: suicidal ideation,depression, opioid use disorder 0.2 mg/kg IV ketamine one time dose arm 4: Patients with suicidal ideation and depression with opioid use disorder who are given comparable amount of placebo (saline) as would have been used with the Ketamine arm

Interventions: intervention 1: Ketamine intervention 2: placebo
Intervention descriptions: intervention 1: single dose IV 0.2 mg/kg ketamine intervention 2: saline infusion

Protocol document: