Conditions: Type 2 Diabetes
Keywords: Type 2 diabetes Insulin biosynthesis Non diabetic control
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 20
Healthy volunteers: yes

Brief summary:
The gut hormone glucagon like peptide-1 (GLP-1) has been shown to have important effects on maintaining the function and health of the insulin producing beta cells. This hormone is known to increase the production rate of new insulin as well as increase the release of insulin into the blood.

Detailed description:
We will measure the rate of new insulin production in subjects with Type 2 diabetes compared to non diabetic subjects. We hypothesize that subjects with Type 2 diabetes make less insulin in response to GLP-1 compared to non diabetic subjects.

Arms:
arm 1: Participants with Type 2 diabetes arm 2: Participants who are non-diabetic will serve as control. treatment is matched to experimental group

Interventions: intervention 1: glucagon like peptide-1 intervention 2: glucose control
Intervention descriptions: intervention 1: GLP-1 1 pmole/kg/min intervention 2: glucose without GLP-1

Protocol document: