Conditions: Bronchiolitis
Keywords: Hypertonic Saline Bronchiolitis Efficacy
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 82
Healthy volunteers: no

Brief summary:
The purpose of this study is to evaluate the efficacy of hypertonic saline vs. normal saline in the treatment of infants hospitalized for bronchiolitis, regarding length of hospital stay, oxygen requirements and clinical outcome.

Detailed description:
Despite bronchiolitis is a very frequent disease among infants, there are still controversies regarding its treatment. Hypertonic saline has been proposed as useful treatment in these children, bur information is still controversial.

The aim is to asses that using Nebulized Hypertonic Saline with bronchodilators (albuterol) may reduce the days of hospitalization and improve clinical outcomes in patients with acute bronchiolitis, compared with using Normal Saline with albuterol.

Arms:
arm 1: Nebulized hypertonic saline (sodium chloride 3%) + albuterol arm 2: Normal saline (sodium chloride 0.9%) + albuterol

Interventions: intervention 1: Hypertonic saline intervention 2: Normal saline
Intervention descriptions: intervention 1: 3 cc nebulized hypertonic saline + albuterol 0.25 mg/kg/day, four times a day (QID), 5 days intervention 2: 3 cc nebulized normal saline + albuterol 0.25 mg/kg/day, four times a day (QID), 5 days

Protocol document: