Conditions: Diseases, Metabolic Insulin Sensitivity
Keywords: Intravenous Feeding Lipid Emulsions, Intravenous
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 12
Healthy volunteers: yes

Brief summary:
Many patients in the hospital who are malnourished or not eating received intravenous feeding or total parenteral nutrition (TPN). Despite improving nutrition, TPN may increase the risk of infections and hospital complications. We do not know why TPN increases hospital complications, but it may be caused by the high sugar or fat content in TPN solutions. The investigators believe that the high sugar and high fat content can limit the ability to fight infections and produce stiffness of blood vessels. This study will compare the effect of high sugar, high fat content or both on blood sugars, blood vessel function, on blood vessel function. The investigators will also compare the effect of different fats (olive oil and soybean) in the TPN solution on the risk of infection and blood vessel function on a total of 12 healthy subjects.

Detailed description:

Arms:
arm 1: Subjects receive 24 hours of infusion of 0.9% normal saline, dextrose (sugar) without fat, ClinOleic (olive oil-based), and Intralipid (soybean-derived fat)

Interventions: intervention 1: Intralipid intervention 2: ClinOleic intervention 3: Dextrose intervention 4: Saline (control)
Intervention descriptions: intervention 1: Infusion of Intralipid (soybean-derived fat) intervention 2: Infusion of ClinOleic (olive oil-based) intervention 3: Infusion of dextrose (sugar) without fat intervention 4: Infusion of 0.9% normal saline

Protocol document: