Conditions: Acute Mountain Sickness
Keywords: exercise performance
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 28
Healthy volunteers: yes

Brief summary:
This study is being conducted to determine the effectiveness of using two FDA approved medications in concert to reduce the likelihood of sickness due to low oxygen levels and to reduce the decrement in physical performance at higher elevations. The investigators hypothesize that this drug combination will reduce the symptoms of acute mountain sickness and improve exercise performance at high altitude compared to placebo.

Detailed description:

Arms:
arm 1: ambrisentan (5mg) once daily for 2 consecutive days theophylline (400mg) once daily for 2 consecutive days arm 2: matched placebo tablets wil be given at the same time to the comparison group as the medications to the experimental group

Interventions: intervention 1: ambrisentan and theophylline intervention 2: placebo
Intervention descriptions: intervention 1: None intervention 2: placebo for comparison group

Protocol document: