Conditions: Hypertension
Keywords: Hypertension, Obese, aliskiren, hydrochlorothiazide, systolic blood pressure, diastolic blood pressure, ramipril, stage 2
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 386
Healthy volunteers: no

Brief summary:
Study to Evaluate the Efficacy and Safety of Aliskiren Hydrochlorothiazide (HCTZ) vs Ramipril in Obese patients (BMI ≥ 30) with Stage 2 Hypertension

Detailed description:

Arms:
arm 1: Aliskiren Hydrochlorothiazide(HCTZ) arm 2: Ramipril

Interventions: intervention 1: Aliskiren Hydrochlorothiazide intervention 2: Ramipril
Intervention descriptions: intervention 1: Aliskiren HCTZ 150/12.5 mg: 1 week; Aliskiren HCTZ 300/25 mg: 7 weeks intervention 2: Ramipril 5mg: 1 week; Ramipril 10 mg: 7 weeks

Protocol document: