Conditions: Tobacco Dependence Smoking
Keywords: smoking cessation medications smoking cessation counseling
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 463
Healthy volunteers: yes

Brief summary:
The purpose of this study was to determine if bupropion plus counseling was more effective than bupropion alone or counseling alone in helping smokers quit smoking.

Detailed description:

Arms:
arm 1: Active bupropion SR plus eight 10-minute individual counseling sessions. arm 2: Active bupropion, No counseling, only medication checks arm 3: Placebo bupropion plus eight 10-minute individual counseling sessions arm 4: Placebo bupropion, No counseling, just medication checks

Interventions: intervention 1: Active bupropion + counseling intervention 2: Active bupropion, No counseling intervention 3: Placebo medication + counseling intervention 4: Placebo medication, No counseling
Intervention descriptions: intervention 1: Medications-Pre-quit: 150 mg bupropion per day 7 days before quit attempt, then 150 mg twice daily for 4 days before quit attempt; then 150 mg bupropion twice daily for eight weeks.

Counseling-Pre-quit: two 10 minutes sessions before quit date; eight 10-minute sessions post quit date. intervention 2: Medication - 150 mg bupropion per day starting week before quit day, then 150 mg twice daily 3 days before quit day, then 150 mg twice daily for eight weeks after quit day.

Counseling: No cessation counseling, only medication checks intervention 3: Placebo bupropion once daily 7 days before quit day, then twice daily 4 days before quit attempt, then twice daily for 8 weeks after quit day.

Counseling: Two 10-minutes sessions before quit day, then eight 10-minutes sessions for eight weeks after quit day. intervention 4: Pre-quit: Placebo medication once daily 7 days before quit day, then twice daily before quit day, then twice daily for 8 weeks after quit day.

Counseling: No counseling, just medication checks

Protocol document: