Conditions: Thyroid Cancer
Keywords: thyroid cancer PET scan recombinant thyrotropin thyroglobulin Thyroid cancer, differentiated epithelial
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 63
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine \[for patients with previously treated well-differentiated thyroid cancer and evidence of residual disease based on serum thyroglobulin (Tg) level\] whether positron emission tomography-computed tomography (PET-CT) fusion scanning performed after recombinant thyroid-stimulating hormone (TSH) (rTSH, thyrotropin alfa for injection) will be more sensitive for the detection of disease sites than PET-CT scanning without rTSH. The study will also determine if this information will significantly alter the therapeutic approach in some patients.

Detailed description:
PET/CT was performed before (basal PET) and 24 - 48 h after rhTSH administration (rhTSH-PET) in 63 patients (52 papillary and 11 follicular thyroid cancers). Images were blindly analyzed by two readers. The proposed treatment plan was prospectively assessed before basal PET, after basal PET, and again after rhTSH-PET.

Arms:
arm 1: Euthyroid Group: Subjects received rhTSH to prepare for radioiodine therapy. arm 2: Hypothyroid Group: Thyroid hormone treatment was withheld before radioiodine therapy.

Interventions: intervention 1: Euthyroid Group
Intervention descriptions: intervention 1: Euthyroid Group: Received rhTSH to prepare for radioiodine therapy.

Protocol document: