Conditions: Anesthesia, General
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 52
Healthy volunteers: no

Brief summary:
The objective of the trial was to show equivalence in recovery from neuromuscular block after a single dose of 4.0 mg/kg sugammadex, administered at first twitch (T1) 3-10% after continuous infusion of rocuronium, between participants receiving maintenance anesthesia using propofol and participants receiving sevoflurane, to investigate the safety and to compare the plasma levels of rocuronium in participants after continuous infusion of rocuronium and before the administration of sugammadex, under either propofol or sevoflurane anesthesia.

Detailed description:

Arms:
arm 1: After receiving sevoflurane and the last dose of rocuronium, at the reappearance of first twitch (T1; 3-10% starting amplitude), a dose of 4.0 mg/kg sugammadex was administered. arm 2: After receiving propofol and the last dose of rocuronium, at the reappearance of first twitch (T1; 3-10% starting amplitude), a dose of 4.0 mg/kg sugammadex was administered.

Interventions: intervention 1: Sugammadex intervention 2: Rocuronium intervention 3: Sevoflurane intervention 4: Propofol
Intervention descriptions: intervention 1: Single dose 4.0 mg/kg sugammadex, administered at T1 3-10% after continuous infusion of rocuronium intervention 2: Single bolus dose 0.6 mg/kg rocuronium and continuous infusion rocuronium intervention 3: Sevoflurane IV administered for induction and maintenance of anesthesia, based on randomization. intervention 4: Propofol IV administered for induction and maintenance of anesthesia, based on randomization.

Protocol document: