Conditions: Nausea and Vomiting
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 64
Healthy volunteers: yes

Brief summary:
This study will compare the effect of prochlorperazine and ondansetron for the treatment of nausea and vomiting in the emergency department.

Detailed description:
Nausea and vomiting can be common symptoms in the emergency department (ED). Antiemetics, agents to treat nausea and vomiting, include phenothiazine derivatives, prokinetic agents, and 5-HT3 antagonists. There have been limited studies on the use of these agents in the ED, and no direct comparisons to 5-HT3 antagonists have been published to date.

Inclusion Criteria:

Patients presenting to the ED with at least one of the following

* nausea
* vomiting documented in the ED

Arms:
arm 1: Patients receiving Prochlorperazine 10mg IV arm 2: Patient receiving Ondansetron 4mg IV

Interventions: intervention 1: Prochlorperazine intervention 2: Ondansetron
Intervention descriptions: intervention 1: Patients receiving Prochlorperazine intervention 2: Patients receiving Ondansetron

Protocol document: