Conditions: Obesity
Keywords: Obesity Endothelial Function Fibrinolytic Balance Baseline
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 13
Healthy volunteers: yes

Brief summary:
T-PA release is impaired in obese subjects. In order to have a better mechanistic understanding of t-PA release, we will compare t-PA release to Flow Mediated Vasodilation, Radial Artery Tonometry, and other markers of endothelial function and oxidative stress.

Detailed description:

Arms:
arm 1: Patients will have flow mediated vasodilation and radial artery tonometry performed. They will then receive 0, 10, 20, 40 ng/100cc/min of intrabrachial bradykinin. Strain gauge plethysmography and blood sampling at each dose will be done to evaluate t-PA release. Blood will also be drawn for other biomarkers.

Interventions: intervention 1: Bradykinin
Intervention descriptions: intervention 1: Intrabrachial - 0, 10, 20, 40 ng/100cc/min over 5 minutes at each dose.

Protocol document: