Conditions: Bacterial Infection
Keywords: complicated skin and skin structure infections linezolid ceftaroline clinical response microbiological response Cellulitis Abscess Wound infection Deeper soft tissue Significant surgical intervention Gram-positive bacterial infection Gram-negative bacterial infection bacterial infection cephalosporin broad-spectrum activity
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 150
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine whether ceftaroline is effective and safe in the treatment of complicated skin and skin structure infections in adults.

Detailed description:
The purpose of this study is to determine whether ceftaroline is effective and safe in the treatment of complicated skin and skin structure infections in adults. The primary focus is bacterial infection.

Arms:
arm 1: Intramuscular every 12 hours arm 2: Intravenous every 12 hours

Interventions: intervention 1: ceftaroline intervention 2: linezolid intervention 3: Aztreonam
Intervention descriptions: intervention 1: 600 mg injected every 12 hours for at least 5 but not more than 14 days intervention 2: 600 mg parenteral infused over 60 minutes for a minimum of 5 days and a maximum of 14 days intervention 3: 1000 mg infused over 60 minutes every 24 hours may be started with linezolid or added later (up to 72 hours after the first dose of linezolid) for subjects with a gram-negative infection indicated.

Protocol document: