Conditions: Secondary Progressive Multiple Sclerosis
Keywords: Secondary progressive Multiple Sclerosis Simvastatin MRI
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 140
Healthy volunteers: no

Brief summary:
To determine whether simvastatin at a dose of 80mg can reduce the rate of whole brain atrophy, as measured by MRI, over a 2-year time-period when compared to placebo.

Detailed description:
The study has now completed see Primary publication:

Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial.

Chataway J, Schuerer N, Alsanousi A, Chan D, MacManus D, Hunter K, Anderson V, Bangham CR, Clegg S, Nielsen C, Fox NC, Wilkie D, Nicholas JM, Calder VL, Greenwood J, Frost C, Nicholas R.

Lancet. 2014 Jun 28;383(9936):2213-21. doi: 10.1016/S0140-6736(13)62242-4.

Arms:
arm 1: Simvastatin 80mg OD arm 2: Placebo

Interventions: intervention 1: Simvastatin intervention 2: Placebo
Intervention descriptions: intervention 1: 80mg simvastatin oral once daily for 24 months intervention 2: Oral placebo tablet once daily for 24 months

Protocol document: