Conditions: Cystic Fibrosis
Keywords: CF
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 21
Healthy volunteers: no

Brief summary:
Gastroesophageal reflux disease (GERD) is a common problem in cystic fibrosis (CF). It may lead to worsening lung function and more respiratory infections for a person with CF. This study will look at treating GERD with a medication, esomeprazole. The medication stops stomach acid from being made. The study will see if there are fewer respiratory infections and improved lung function in patients with CF when taking esomeprazole.

Detailed description:
This is a randomized, placebo controlled intervention study in patients with CF who have a history of frequent exacerbations. Treatment duration is 6 months.

Arms:
arm 1: A matching placebo (sugar pill) to esomeprazole 40mg twice daily arm 2: Esomeprazole 40mg twice daily

Interventions: intervention 1: Esomeprazole intervention 2: Placebo
Intervention descriptions: intervention 1: None intervention 2: Sugar pill

Protocol document: