Conditions: Rheumatoid Arthritis
Keywords: Rheumatoid Arthritis RA AZD5672
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 373
Healthy volunteers: no

Brief summary:
This study is being carried out to investigate if AZD5672 is effective in treating Rheumatoid Arthritis (RA) and if so how it compares to placebo (a substance which does not have any action) and etanercept (a medicine already available to treat Rheumatoid Arthritis) when added to treatment with methotrexate. The purpose of this study is also to find out which dose of AZD5672 is the most effective at treating RA and to find out how well the body tolerates AZD5672 when taken for up to 12 weeks.

Detailed description:

Arms:
arm 1: None arm 2: 20mg arm 3: 50mg arm 4: 100mg arm 5: 150mg arm 6: None

Interventions: intervention 1: AZD5672 intervention 2: Etanercept intervention 3: Placebo intervention 4: AZD5672 intervention 5: AZD5672 intervention 6: AZD5672
Intervention descriptions: intervention 1: 20 mg oral, once daily intervention 2: 50 mg, subcutaneous injection, weekly intervention 3: placebo, oral, once daily intervention 4: 50 mg oral, once daily intervention 5: 100 mg oral, once daily intervention 6: 150 mg oral, once daily

Protocol document: