Conditions: Marijuana Abuse
Keywords: withdrawal acute effects cognitive performance Marijuana Use Marijuana Abstinence
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 24
Healthy volunteers: yes

Brief summary:
A subset of heavy marijuana users have trouble quitting marijuana use and the number of those seeking treatment for problems related to marijuana is increasing. The purpose of this research study is to investigate whether dronabinol can reduce withdrawal effects associated with stopping marijuana use, if dronabinol can reduce the rewarding effects of smoked marijuana, and whether there are any cognitive performance deficits associated with dronabinol doses that produce such effects.

Detailed description:

Arms:
arm 1: 0, 30, 60, and 120mf dronabinol was administered in a randomized within-subjects crossover study to compare the medication dose effects of cannabis withdrawal, cognitive performance, and response to acute cannabis dosing

Interventions: intervention 1: Dronabinol 30mg/day intervention 2: Dronabinol 60mg/day intervention 3: Dronabinol 120mg/day intervention 4: Placebo
Intervention descriptions: intervention 1: 10mg dronabinol administered 3x/day for 5 days intervention 2: 20mg dronabinol administered 3x/day for 5 days intervention 3: 40mg dronabinol administered 3x/day for 5 days intervention 4: placebo dronabinol administered 3x/day for 5 days

Protocol document: