Conditions: Anxiety
Keywords: quality of life lorazepam anxiety premedication surgery Adult patients Ambulatory Surgical Procedures Postoperative Period
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 400
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine whether lorazepam, which is used to lower preoperative anxiety, also improves postoperative recovery.

This study data will also be used for further research aiming to identify vulnerable patients in the day-case surgery setting.

Detailed description:
Since the early 1980s, the investigators have seen a shift towards day-case surgery. Before surgery, many patients have negative feelings about the surgical procedure. These anxieties have various negative effects. To reduce this resistance preoperative administration of an anxiolytic drug is administered, typically a benzodiazepine. The investigators know that benzodiazepines are effective in reducing anxiety, but up to now there is nog good scientific evidence about the effectiveness of lorazepam on the quality of recovery in day-case surgery patients.

The ultimate goal of our research project is to identify patients who would benefit from preoperative benzodiazepine administration and who not. Identification would substantially contribute to optimal medical decision making.

Arms:
arm 1: Lorazepam 4mg/4ml arm 2: NaCl 0.9% 4ml

Interventions: intervention 1: Lorazepam intervention 2: NaCl 0.9% (Sodium Chloride)
Intervention descriptions: intervention 1: Once 1mg \<75kg body weight, 1.5mg 75kg and \>75kg body weight, IV, before surgery intervention 2: Once 1ml \<75kg body weight, 1.5ml 75kg or \>75kg body weight, IV, before surgery

Protocol document: