Conditions: Healthy
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 22
Healthy volunteers: yes

Brief summary:
The objective of the current study is to investigate the effect of the P-gp inducer rifampicin on the pharmacokinetics (PK) of afatinib in healthy male volunteers

Detailed description:

Arms:
arm 1: Tablet, Oral administration with 240 mL of water arm 2: Tablet, Oral administration with 240 mL of water

Interventions: intervention 1: Afatinib intervention 2: Afatinib intervention 3: Rifampicin
Intervention descriptions: intervention 1: single dose intervention 2: single dose intervention 3: multiple doses

Protocol document: