Conditions: Upper Respiratory Infection
Keywords: Cold Upper Respiratory Infection
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 84
Healthy volunteers: no

Brief summary:
Assesses the efficacy of treatment with montelukast 10 mg PO QD x 5 days versus placebo for the treatment of viral-induced upper respiratory infection in healthy adults aged 18-50 years.

Detailed description:
This is a randomized double-blinded placebo controlled trial to assess the efficacy of treatment with montelukast 10 mg PO QD x 5 days versus placebo for the treatment of viral-induced upper respiratory infection in healthy adults aged 18-50 years. All subjects complete daily assessments of cold symptoms, nasal clearance rates and secretion rates during each day of the study. Phlebotomy is performed once for the determination of cytokine genotyping and allergy skin testing is performed once for the assessment of atopy.

Arms:
arm 1: Treated for 4 months with montelukast 4 mg per day arm 2: Treated for 4 months with placebo

Interventions: intervention 1: Montelukast intervention 2: Placebo
Intervention descriptions: intervention 1: None intervention 2: None

Protocol document: