Conditions: Hypertension
Keywords: Hypertension Blood pressure Nebivolol Bystolic (TM) Metoprolol ER (TM)
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 12
Healthy volunteers: no

Brief summary:
The study is designed to compare the effects of nebivolol (10, 20, 40mg/day) with another beta blocker, extended-release metoprolol, at a range of doses. Its purpose is to study the mechanism of action of nebivolol on forearm blood flow, nitric oxide availability and other biomarkers.

Detailed description:

Arms:
arm 1: Nebivolol arm 2: Metoprolol ER (TM)

Interventions: intervention 1: Nebivolol intervention 2: Metoprolol ER (TM)
Intervention descriptions: intervention 1: nebivolol 10mg, 20mg, 40mg daily dosage, oral administration intervention 2: Metoprolol ER 100mg, 200mg, 400mg, daily dosage, oral administration

Protocol document: