Conditions: Hypertriglyceridemia
Keywords: triglycerides hypertriglyceridemia omega-3 n-3 eicosapentaenoic acid EPA docosahexaenoic acid DHA flow mediated dilation fish Moderate hypertriglyceridemia
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 28
Healthy volunteers: no

Brief summary:
The purpose of this study is to evaluate the cardiovascular and lipid effects of two doses of an omega-3 fatty acid concentrate in a group of people who normally are not treated for high lipids.

Detailed description:

Arms:
arm 1: 4 g/day Dose Prescription Omega-3 acid ethyl esters (P-OM3)capsules(4) for first intervention (8 weeks), followed by 1g/day P-OM3 capsules(4) for 2nd intervention (8 weeks), followed by Placebo corn oil capsules, 4/day, for the 3rd intervention (8 weeks). arm 2: 1g capsules for 8-wks, followed by 6-wk washout. 4g capsules for 8 wks,followed by 6-wk washout. Placebo capsules for 8-wks. arm 3: Corn Oil placebo capsules for 8-wks, followed by 6-wk washout. 4g P-OM3 capsules for 8-wks, followed by 6-wk washout. 1g P-OM3 for 8-wks. arm 4: 4g capsules for 8-wks, followed by 6-wk washout. Placebo capsules for 8-wks, followed by 6-wk washout. 1g capsules for 8 wks. arm 5: 1g capsules for 8-wks, followed by 6-wk washout. Placebo capsules for 8-wks, followed by 6-wk washout. 4g capsules for 8 wks. arm 6: Corn oil placebo capsules for 8-wks, followed by 6-wk washout.1g capsules for 8-wks, followed by 6-wk washout. 4g capsules for 8 wks.

Interventions: intervention 1: 4/day of 4g P-OM3 capsules intervention 2: 4/day of 1g P-OM3 capsules intervention 3: Corn Oil Placebo, 4 capsules/day for 8 weeks
Intervention descriptions: intervention 1: 4/day of 4g P-OM3 capsules for 8 weeks intervention 2: 4/day of 1g P-OM3 capsules for 8 weeks intervention 3: 4 capsules per day of corn oil placebo for 8 weeks

Protocol document: