Conditions: Pain
Keywords: Analgesic effect
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 103
Healthy volunteers: yes

Brief summary:
The primary aim of this study is to investigate if AZD1386 can relieve the pain induced by the surgical removal of one lower wisdom-tooth. This will be done by comparing the effect of AZD1386 to placebo ("inactive substance") on pain. A number of patients will instead receive the common painkiller naproxen for comparison purposes. Rescue medication, acetaminophen, will be allowed if a need for additional painkillers would arise. A number of patients will receive naproxen as control.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: Placebo matching AZD1386

Interventions: intervention 1: AZD1386 intervention 2: Naproxen intervention 3: Placebo
Intervention descriptions: intervention 1: 95mg, oral solution, single dose intervention 2: 500mg, capsule, single dose intervention 3: AZD1386 Placebo oral solution

Protocol document: