Conditions: Healthy
Keywords: warfarin pharmacokinetics drug transporter healthy volunteer drug interaction rifampin
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 10
Healthy volunteers: yes

Brief summary:
The purpose of this study is to determine the importance of uptake drug transporters in the drug disposition of warfarin. We predict that the elimination of warfarin will be decreased when co-dosed with an inhibitor of uptake drug transporters.

Detailed description:

Arms:
arm 1: None

Interventions: intervention 1: warfarin plus rifampin intervention 2: warfarin
Intervention descriptions: intervention 1: warfarin 7.5mg po x 1; rifampin 600mg IV x 1 intervention 2: warfarin 7.5mg po x 1

Protocol document: