Conditions: Venous Thromboembolism
Keywords: Anticoagulants Enoxaparin sodium venous thromboembolism. thromboembolism Thrombosis deep vein thrombosis DU-176b Edoxaban factor Xa hip fracture surgery embolism
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 92
Healthy volunteers: no

Brief summary:
The objective of this study is to evaluate the safety and efficacy of DU-176b compared with enoxaparin sodium for the prevention of venous thromboembolism in patients after elective hip fracture surgery.

Detailed description:

Arms:
arm 1: DU-176b oral tablets, 30 mg., taken once daily for 2 weeks, initiated within 6 to 24 hours after surgery arm 2: Enoxaparin sodium 20mg(=2000IU)/0.2ml twice daily, subcutaneous injection for 2 weeks, initiated within 24 to 36 hours after surgery

Interventions: intervention 1: DU-176b (edoxaban) intervention 2: Enoxaparin sodium 20mg
Intervention descriptions: intervention 1: None intervention 2: None

Protocol document: