Conditions: Smoking Cessation
Keywords: smoking cessation smoking cessation in COPD
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 504
Healthy volunteers: no

Brief summary:
This study is to be conducted in subjects with mild-to-moderate COPD who are cigarette smokers with the intent of demonstrating differences in smoking cessation between varenicline and placebo.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: placebo intervention 2: Varenicline Tartarate
Intervention descriptions: intervention 1: 1mg (placebo) by mouth twice daily for 12 weeks (first week is up titration schedule---0.5mg once daily for 3 days, 0.5mg twice daily for 4 days) intervention 2: 1 mg by mouth twice daily for 12 weeks (first week is up titration schedule---0.5mg once daily for 3 days, 0.5mg twice daily for 4 days)

Protocol document: