Conditions: Allergic Rhinitis
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 21
Healthy volunteers: no

Brief summary:
An H3 receptor antagonist should reduce the congestion associated with allergic rhinitis. A nasal allergen challenge will be given to patients to induce rhinitis symptoms and acoustic rhinometry will be used to measure the congestion.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None arm 4: None

Interventions: intervention 1: Placebo intervention 2: Allegra intervention 3: Allegra-D intervention 4: PF-03654746
Intervention descriptions: intervention 1: A single oral dose of Placebo is dosed during the study in order to ascertain the effect of placebo on measures and in order to maintain the blind of the other drugs. intervention 2: A single oral dose of Allegra is dosed to subjects in combination with PF-03654746. intervention 3: A single oral dose of Allegra-D is dosed to subjects as an active comparator. intervention 4: A single oral dose of PF-03654746 is the investigational drug being studied.

Protocol document: