Conditions: Psoriasis
Keywords: Psoriasis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 120
Healthy volunteers: no

Brief summary:
The purpose of this study is to evaluate the use of etanercept as a replacement therapy for ciclosporin in patients with plaque psoriasis.

Detailed description:
The purpose of this study is to evaluate the efficacy and safety of etanercept as a replacement therapy for ciclosporin in patients with moderate to severe plaque psoriasis who have achieved an adequate response with ciclosporin.

Arms:
arm 1: Participants were administered a 50 mg dose of etanercept subcutaneously once a week after an initial course of ciclosporin. arm 2: Participants were administered placebo subcutaneously once a week after an initial course of ciclosporin.

Interventions: intervention 1: Etanercept intervention 2: Placebo
Intervention descriptions: intervention 1: Etanercept 50 mg QW initiated during taper of ciclosporin intervention 2: Randomized to placebo during taper of ciclosporin

Protocol document: