Conditions: Obesity Hypertension Hyperglycemia
Keywords: Impaired Fasting Glucose FPG >100-<126 mg/dL
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 53
Healthy volunteers: no

Brief summary:
The main purposes of this study are to find out if the study drug losartan (Cozaar) or placebo ("sugar pill") has an effect on insulin sensitivity (how your body responds to insulin) and to measure the effect of the study drug losartan or placebo on how the arteries in your arm dilate (enlarge to carry more blood).

We hope to learn if taking losartan changes the amount of certain proteins in the blood that effect blood vessel function.

Losartan is approved by the US FDA to treat high blood pressure. It will take approximately 4 months for you to complete this study.

Detailed description:

Arms:
arm 1: Losartan 100 mg 1 tab po QD arm 2: Placebo 1 tab po QD

Interventions: intervention 1: losartan intervention 2: Placebo control
Intervention descriptions: intervention 1: losartan 100 mg tablets 1 tab po QD intervention 2: Placebo 1 po QD

Protocol document: