Conditions: Hypotension After Reperfusion in Liver Transplantation
Keywords: postreperfusion syndrome phenylephrine epinephrine liver transplantation
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 96
Healthy volunteers: no

Brief summary:
Postreperfusion syndrome (PRS) is a relatively common phenomenon in patients undergoing liver transplantation which is characterized by an acute drop in blood pressure immediately after the prefusion is restored to the transplanted liver. We hypothesized that PRS would be prevented when phenylephrine or epinephrine is administered immediately prior to reperfusion in liver transplantation.

Detailed description:

Arms:
arm 1: 100 mcg of phenylephrine is administered at the time of reperfusion arm 2: 10 mcg of epinephrine is administered iv at the time of reperfusion arm 3: 10 ml of normal saline is administered at the time of reperfusion

Interventions: intervention 1: phenylephrine intervention 2: epinephrine intervention 3: placebo control
Intervention descriptions: intervention 1: 100 mcg of phenylephrine (volume 10 ml) iv at the time of reperfusion intervention 2: 10mcg of epinephrine (volume 10 ml) is administered iv at the time of reperfusion intervention 3: 10ml of normal saline is administered at the time of reperfusion

Protocol document: