Conditions: Arthritis, Rheumatoid
Keywords: Rheumatoid Arthritis Arthritis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 550
Healthy volunteers: no

Brief summary:
The purpose of this study is to examine the effects of etanercept (10 mg and 25 mg) compared with methotrexate (up to 8 mg per week) on the slowing of joint destruction.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None

Interventions: intervention 1: Etanercept intervention 2: Etanercept intervention 3: Methotrexate
Intervention descriptions: intervention 1: 10 mg twice weekly, subcutaneous injection for 52 weeks intervention 2: 25 mg, twice weekly, subcutaneous injection for 52 weeks intervention 3: up to 8 mg per week, oral dosing for 52 weeks

Protocol document: