Conditions: Heart Failure Ventricular Dysfunction, Left
Keywords: Heart Failure Ventricular Dysfunction NTproBNP
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 252
Healthy volunteers: no

Brief summary:
The purpose is to study if HF treatment guided by NTproBNP in addition to clinical symptoms and signs is more effective than treatment guided by clinical symptoms and signs alone in patients with HF and left ventricular systolic dysfunction

Detailed description:

Arms:
arm 1: Treatment guided by clinical symptoms and signs + NTproBNP arm 2: Treatment guided by clinical symptoms and signs

Interventions: intervention 1: Captopril intervention 2: Enalapril intervention 3: Lisinopril intervention 4: Ramipril intervention 5: Trandolapril intervention 6: Bisoprolol intervention 7: Carvedilol intervention 8: Metoprolol succinate intervention 9: Candesartan intervention 10: Valsartan intervention 11: Eplerenone intervention 12: Spironolactone intervention 13: Diuretics intervention 14: HF treatment according to Swedish guidelines intervention 15: Blood samples intervention 16: The Kansas City Cardiomyopathy Questionnaire (KCCQ)
Intervention descriptions: intervention 1: None intervention 2: None intervention 3: None intervention 4: None intervention 5: None intervention 6: None intervention 7: None intervention 8: None intervention 9: None intervention 10: None intervention 11: None intervention 12: None intervention 13: None intervention 14: None intervention 15: None intervention 16: None

Protocol document: