Conditions: Overactive Bladder
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 20
Healthy volunteers: no

Brief summary:
This study will evaluate the cerebrospinal fluid levels of trospium chloride (Sanctura XR®) and oxybutynin immediate release (Oxybutynin IR) on memory performance in patients with overactive bladder and age associated memory impairment.

Detailed description:

Arms:
arm 1: Sanctura XR® (trospium chloride), 60mg once daily for 10 days arm 2: Oxybutynin IR (oxybutynin immediate release), 5 mg three times daily for 2 days arm 3: Oxybutynin IR placebo three times daily for 2 days

Interventions: intervention 1: trospium chloride intervention 2: oxybutynin IR intervention 3: oxybutynin IR placebo
Intervention descriptions: intervention 1: trospium chloride (60mg) once daily for 10 days intervention 2: oxybutynin IR (5 mg) three times daily for 2 days intervention 3: oxybutynin IR placebo three times daily for 2 days

Protocol document: