Conditions: Alzheimer Disease
Keywords: Amyloid imaging Positron Emission Tomography 18F-AV-45 florbetapir F 18 Diagnostic imaging
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 20
Healthy volunteers: yes

Brief summary:
This study will test two different doses of florbetapir F 18 to determine which dose is best to image amyloid plaques in the brains of Alzheimer's Disease (AD) patients using a positron emission tomography (PET) scanner.

Detailed description:

Arms:
arm 1: Subjects with AD who received 111MBq (3 mCi) of florbetapir F 18; MBq=megabecquerel arm 2: Healthy controls who received 111MBq (3 mCi) of florbetapir F 18 arm 3: Subjects with AD who received 370MBq (10 mCi) of florbetapir F 18 arm 4: Healthy controls who received 370MBq (10 mCi) of florbetapir F 18.

Interventions: intervention 1: florbetapir F 18
Intervention descriptions: intervention 1: single dose IV injection

Protocol document: