Conditions: Open-angle Glaucoma Ocular Hypertension
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 643
Healthy volunteers: no

Brief summary:
This study was to compare the safety and efficacy of the preservative-free formulation of 0.0015% MK2452 (tafluprost) and preservative-free 0.5% timolol maleate in patients with open-angle glaucoma and ocular hypertension. This study was to demonstrate that the preservative-free formulation of 0.0015% tafluprost is non-inferior to preservative-free 0.5% timolol maleate.

Detailed description:

Arms:
arm 1: Preservative-free tafluprost arm 2: Preservative-free timolol maleate

Interventions: intervention 1: Preservative-Free Tafluprost intervention 2: Comparator: timolol
Intervention descriptions: intervention 1: One drop of preservative-free vehicle per eye in the morning, and one drop of preservative-free tafluprost (0.0015%) per eye in the evening for 12 weeks intervention 2: One drop of preservative-free timolol maleate (0.5%) per eye twice daily for 12 weeks

Protocol document: