Conditions: Hypertension
Keywords: Hypertension Valsartan Amlodipine single pill combination BP control ABPM Hypertensive patients not adequately controlled by mono antihypertensive drugs
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 564
Healthy volunteers: no

Brief summary:
The purpose of this study was to compare the efficacy and safety of Valsartan/Amlodipine (EXforge®) with nifedipine, as well as vascular function index.

Detailed description:

Arms:
arm 1: Valsartan/amlodipine 80/5 mg, one tablet once daily at 8:00 a.m. everyday for 12 weeks. arm 2: Nifedipine GITS (Gastro-Intestinal Therapeutic System ) 30 mg, one tablet once daily at 8:00 a.m. everyday for 12 weeks.

Interventions: intervention 1: Valsartan/Amlodipine intervention 2: Nifedipine
Intervention descriptions: intervention 1: Valsartan/Amlodipine 80/5mg single pill combination (SPC) intervention 2: Nifedipine GITS (Gastro-Intestinal Therapeutic System ) 30 mg

Protocol document: