Conditions: Cardiovascular Disorder Diabetes Mellitus
Keywords: cardiovascular disorder
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 808
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine the efficacy of switching to a combination tablet ezetimibe/simvastatin (10mg/20mg) versus rosuvastatin (10 mg) versus doubling the statin dose in those patients who have cardiovascular disease and diabetes mellitus not adequately controlled on simvastatin 20 mg or atorvastatin 10 mg.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None

Interventions: intervention 1: ezetimibe (+) simvastatin intervention 2: simvastatin 40 mg or atorvastatin 20 mg intervention 3: Rosuvastatin intervention 4: atorvastatin 10 mg or simvastatin 20 mg
Intervention descriptions: intervention 1: ezetimibe/simvastatin 10/20 mg tablets, taken once daily for six weeks. intervention 2: simvastatin 40 mg or atorvastatin 20 mg tablets, taken once daily for six weeks. intervention 3: rosuvastatin 10 mg tablets, taken once daily for six weeks. intervention 4: All patients will take atorvastatin 10 mg tablets OR simvastatin 20 mg tablets, taken once daily in a 6-week screening/stabilization period prior to randomization.

Protocol document: