Conditions: Migraine
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 349
Healthy volunteers: no

Brief summary:
Metoclopramide is an effective intravenous treatment for acute migraine attacks, but we do not know the best dose to administer. This study compares three different doses of metoclorpamide.

Detailed description:
Patients with acute migraine attacks are eligible for enrollment if they present to the emergency department of Montefiore Medical Center. Pain scores are assessed at baseline and every 30 minutes for two hours, and then again by telephone 48 hours after discharge

Arms:
arm 1: Metoclopramide 10 mg+ diphenhydramine 25 mg. This medication was administered as an intravenous drip over 20 minutes arm 2: metoclopramide 20 mg + diphenhydramine 25 mg. Administered as an intravenous drip over 20 minutes. arm 3: metoclopramide 40 mg + diphenhdyramine 25mg. Administered as an intravenous drip over 20 minutes.

Interventions: intervention 1: metoclopramide intervention 2: metoclopramide intervention 3: metoclopramide intervention 4: Diphenhydramine 25mg
Intervention descriptions: intervention 1: metoclopramide 20 mg intervention 2: metoclopramide 40 mg intervention 3: metoclopramide 10 mg intervention 4: Diphenhydramine 25mg, administered as an intravenous drip over 20 minutes

Protocol document: