Conditions: Chronic Kidney Disease
Keywords: metabolic acidosis chronic kidney disease Estimated GFR 15-45
Allocation: NON_RANDOMIZED | Intervention model: SEQUENTIAL
Enrollment: 20
Healthy volunteers: no

Brief summary:
This study will enroll 25 patients with kidney disease to evaluate the effects of different doses of sodium bicarbonate (baking soda) on levels of bicarbonate in the blood, kidney function and muscle strength. The investigators will also evaluate safety and tolerability of different doses.

Detailed description:
This study enrolled 20 patient to evaluate the effects of different doses of sodium bicarbonate. We will test serum bicarbonate levels, potassium levels and muscle function.

Arms:
arm 1: Sequential design. Participants will be getting different doses of sodium bicarbonate during the study. arm 2: Sequential design. Participants will be getting either placebo of different doses during the study.

Interventions: intervention 1: Sodium bicarbonate intervention 2: Placebos
Intervention descriptions: intervention 1: Sodium bicarbonate at 3 different doses or placebo. The different doses tested will be: 0.3 mEq/kg of ideal body weight, 0.6 mEq/kg of ideal body weight and 1 mEq/kg pf ideal body weight intervention 2: Placebo at 3 different doses to match Sodium bicarbonate dosing

Protocol document: