Conditions: Pulmonary Disease, Chronic Obstructive
Keywords: Dry Powder for Inhalation Chronic Obstructive Pulmonary Disease Lung Function testing
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 87
Healthy volunteers: no

Brief summary:
Safety and efficacy (measured by spirometry) of UK-432,097 administration will be tested in patients with chronic obstructive pulmonary disease.

Detailed description:

Arms:
arm 1: Active treatment given BID via a double pin monodose capsule inhaler device arm 2: Placebo treatment given BID via a single pin monodose inhaler device

Interventions: intervention 1: UK-432,097 intervention 2: Placebo
Intervention descriptions: intervention 1: Formulated as a dry powder, supplied as capsules and administered using an atomizer device. Given as either 150mcg, 450mcg or 1350mcg BID. intervention 2: Capsules containing 100% lactose administered BID using an atomizer device

Protocol document: