Conditions: Asthma
Keywords: Nasal Allergen Challenge, Inhaled Allergen Challenge, Asthma
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 11
Healthy volunteers: no

Brief summary:
The purpose of this study is to evaluate the relationship between upper and lower airway allergen-induced cytokine responses in mild asthmatics by attempting to demonstrate the following: 1) a positive correlation between allergen-induced Type 2 T-helper cell (Th2) cytokines (interleukins 5 and 13) in sputum and nasal exudates; and 2) a positive correlation between effects of prednisone versus placebo on Th2 cytokines in sputum and nasal exudates.

Detailed description:

Arms:
arm 1: Prednisone in the first crossover treatment period and placebo in the second crossover treatment period arm 2: Placebo in the first crossover treatment period and prednisone in the second crossover treatment period

Interventions: intervention 1: Prednisone intervention 2: Placebo
Intervention descriptions: intervention 1: Prednisone (25 mg) tablets as a single oral dose on Day 1 of each study period intervention 2: Matching placebo tablets as a single oral dose on Day 1 of each study period

Protocol document: