Conditions: Pain
Keywords: Abdominal Laparoscopic Surgery
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 244
Healthy volunteers: yes

Brief summary:
This research study will look at the pain relieving ability and safety of using repeated doses of intravenous (into the vein \[IV\]) acetaminophen in the treatment of moderate postoperative pain after planned or elective abdominal laparoscopic surgery, such as a laparoscopic abdominal hysterectomy or laparoscopic cholecystectomy (removal of the gall bladder).

Detailed description:
To assess the analgesic efficacy of repeated doses of intravenous acetaminophen (IV APAP) versus Placebo in the treatment of moderate postoperative pain after abdominal laparoscopic surgery.

Arms:
arm 1: IV Placebo 100 ml dosed every every 6 hours for 24 hours (4 doses total). arm 2: IV Placebo 65 ml dosed every every 4 hours for 24 hours (6 doses total). arm 3: IV Acetaminophen 1 gm dosed every every 6 hours for 24 hours (4 doses total). arm 4: IV Acetaminophen 650 mg dosed every every 4 hours for 24 hours (6 doses total).

Interventions: intervention 1: IV Placebo intervention 2: IV Placebo intervention 3: IV Acetaminophen intervention 4: IV Acetaminophen
Intervention descriptions: intervention 1: IV, every 6 hours for 24 hours (4 doses total) intervention 2: IV, every 4 hours for 24 hours (6 doses total) intervention 3: IV, every 6 hours for 24 hours (4 doses total) intervention 4: IV, every 4 hours for 24 hours (6 doses total)

Protocol document: