Conditions: Squamous Cell Carcinoma of Head and Neck
Keywords: squamous cell carcinoma of head and neck lapatinib ErbB1/ErbB2 inhibitor apoptosis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 107
Healthy volunteers: no

Brief summary:
This is a study comparing the activity of lapatinib versus placebo followed by chemoradiation. This study is designed to explore the effects of lapatinib monotherapy on apoptosis/necrosis, in pre-treatment and post-treatment tumour tissue samples in subjects with locally advanced squamous cell carcinoma of head and neck.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Lapatinib oral tablets intervention 2: Placebo
Intervention descriptions: intervention 1: None intervention 2: None

Protocol document: