Conditions: Healthy
Keywords: Healthy volunteers
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 33
Healthy volunteers: yes

Brief summary:
The purpose of this study is to determine the pharmacogenetics, pharmacokinetics, and drug-drug interactions of sitagliptin therapy.

Detailed description:

Arms:
arm 1: ABCB1 CGC/CGC genetic make-up; sitagliptin 100 mg x 1 dose; atorvastatin 40 mg x 5 doses arm 2: ABCB1 CGC/TTT genetic make-up; sitagliptin 100 mg x 1 dose; atorvastatin 40 mg x 5 doses arm 3: ABCB1 TTT/TTT genetic make-up; sitagliptin 100 mg x 1 dose; atorvastatin 40 mg x 5 doses

Interventions: intervention 1: Sitagliptin intervention 2: atorvastatin
Intervention descriptions: intervention 1: sitagliptin 100 mg x 1 dose intervention 2: atorvastatin 40 mg x 5 doses

Protocol document: