Conditions: Chronic Plaque Psoriasis
Keywords: Plaque psoriasis inflammatory skin disease skin condition, thickening flaking scaly patches skin disease
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 130
Healthy volunteers: no

Brief summary:
Loading dose, four arm, double-blind, parallel group, placebo-controlled study comparing single and multiple doses of AIN457 to placebo in patients with a diagnosis of moderate to severe chronic plaque psoriasis.

Detailed description:

Arms:
arm 1: Participants randomized to this arm received AIN457 3 mg/kg on day 1, and then matching placebo on days 15 and 29. arm 2: Participants randomized to this arm received AIN457 10 mg/kg on day 1, and then matching placebo on days 15 and 29. arm 3: Participants randomized to this arm received AIN457 3 mg/kg on days 1, 15 and 29. arm 4: Participants randomized to this arm received matching placebo to AIN457 on days 1, 15 and 29

Interventions: intervention 1: AIN457 intervention 2: Placebo
Intervention descriptions: intervention 1: AIN457 was administered intravenously. intervention 2: Matching placebo to AIN457 was administered intravenously.

Protocol document: