Conditions: Normal Pressure Hydrocephalus
Keywords: Amyloid NPH Normal pressure hydrocephalus PET Positron Emission Tomography SUVR Standard uptake value ratios
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 7
Healthy volunteers: no

Brief summary:
This study will determine the level of association between the quantitative estimates of brain uptake of \[18F\]flutemetamol and the quantitative immunohistochemical estimates of amyloid levels in biopsy samples previously obtained during shunt placement in patients who have normal pressure hydrocephalus (NPH).

Detailed description:

Arms:
arm 1: None

Interventions: intervention 1: [18F] Flutemetamol
Intervention descriptions: intervention 1: All subjects will receive an intravenous (IV) dose of \[18F\]flutemetamol (less than 10µg flutemetamol). The nominal activity of a single administration of \[18F\]flutemetamol will be 185 megabecquerels (MBq).

Protocol document: