Conditions: Dental Caries
Keywords: Enamel remineralization Fluoride caries
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 83
Healthy volunteers: yes

Brief summary:
This study will use an oral in-situ caries model to study remineralization of enamel due to the action of different combinations of fluoride salts delivered from dentifrices.

Detailed description:

Arms:
arm 1: Fluoride toothpaste containing sodium fluoride (NaF) arm 2: Fluoride toothpaste containing stannous fluoride (SnF) and NaF. arm 3: Fluoride toothpaste containing sodium monofluorophosphate (NaMFP) and NaF. arm 4: Low fluoride toothpaste containing NaF

Interventions: intervention 1: NaF intervention 2: SnF intervention 3: NaMFP
Intervention descriptions: intervention 1: Fluoride toothpaste containing sodium fluoride as 1450 parts per million (ppm) F, 675 ppmF, 450 ppmF, 350ppmF. intervention 2: Fluoride toothpaste containing stannous fluoride (1100 ppmF) intervention 3: Fluoride toothpaste containing sodium monofluorophosphate (1000 ppmF)

Protocol document: