Conditions: Healthy
Keywords: menses women healthy controls Healthy females with regular menstrual cycles
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 8
Healthy volunteers: yes

Brief summary:
The goal of this series of challenge studies is to examine the impact of menstrual cycle phase on cortical GABA response to administration of agents with either direct (benzodiazepines) or indirect (progesterone, fluoxetine) GABA modulating properties. While the impact of these agents on cortical GABA levels in women with premenstrual dysphoric disorder (PMDD) is of interest, this study is designed primarily for those women without a psychiatric illness.

Detailed description:

Arms:
arm 1: Zolpidem will be administered twice to each participant; once in the follicular and luteal phases of the menstrual cycle. arm 2: Progesterone will be administered twice to each participant; once in both the follicular and luteal phases of the menstrual cycle. arm 3: Fluoxetine will be administered twice to each participant; once in both the follicular and luteal phases of the menstrual cycle.

Interventions: intervention 1: Fluoxetine intervention 2: Zolpidem intervention 3: Progesterone
Intervention descriptions: intervention 1: Fluoxetine 20 mg by mouth in the follicular and luteal phase of the menstrual cycle per participant. intervention 2: Zolpidem 10 mg by mouth in the follicular and luteal phase of the menstrual cycle per participant. intervention 3: Progesterone 800 mg by mouth will be administered to each participant once in the follicular and luteal phases of the menstrual cycle.

Protocol document: