Conditions: Vulvar Pain Symptoms Vulvodynia (Chronic Vulvar Pain)
Keywords: Vulvar Pain
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 9
Healthy volunteers: yes

Brief summary:
The purpose of this research study is to evaluate if the medication gabapentin lessens the vulvar pain some women experience.

Detailed description:
There is not a "best" treatment plan for vulvar pain including vulvodynia (chronic vulvar pain) and vulvar vestibulitis syndrome (VVS, chronic vulvar pain localized to the vaginal opening). We propose that vulvodynia is a neuropathic pain (pain that effects the nervous system) as characterized by pain from stimuli that is not usually painful, stimuli that would not usually be painful causing significant pain, and burning pain. Gabapentin has been shown to be effective in treating chronic pain.

Arms:
arm 1: Gabapentin (Neurontin) titration and dosing for total of 8 weeks (Cross over) arm 2: Placebo titration and dosing for total of 8 weeks (Cross over)

Interventions: intervention 1: Gabapentin intervention 2: Placebo oral capsule
Intervention descriptions: intervention 1: 300 mg. capsules

Dosage schedule for weeks 1 and 2 and weeks 12 and 13:

1. day 1 you will take 1 capsule for the day
2. day 2 you will take 1 capsule 2 times for that day
3. days 3-6 you will take 1 capsule 3 times for those days
4. days 7-9 you will take 1 capsule in am and 1 capsule at noon, 2 capsules at bedtime each day
5. days 10-12 you will take 1 capsule in am and 2 capsules at noon and 2 capsules at bedtime each day
6. days 13-14 you will take 2 capsules 3 times each day
7. continue on 2 capsules 3 times each day for 6 weeks after maximum dose of 1800 mg is reached after weeks 2 and 13.
8. at completion of study treatment you will titrate off study drug over a weeks time. intervention 2: Placebo capsules

Dosage schedule for weeks 1 and 2 and weeks 12 and 13:

1. day 1 you will take 1 capsule for the day
2. day 2 you will take 1 capsule 2 times for that day
3. days 3-6 you will take 1 capsule 3 times for those days
4. days 7-9 you will take 1 capsule in am and 1 capsule at noon, 2 capsules at bedtime each day
5. days 10-12 you will take 1 capsule in am and 2 capsules at noon and 2 capsules at bedtime each day
6. days 13-14 you will take 2 capsules 3 times each day
7. continue on 2 capsules 3 times each day for 6 weeks after maximum dose of 1800 mg is reached after weeks 2 and 13.
8. at completion of study treatment you will titrate off study drug over a weeks time.

Protocol document: