Conditions: Multiple Sclerosis
Keywords: PPMS Primary progressive MS Primary progressive multiple sclerosis Rituxan MS
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 439
Healthy volunteers: no

Brief summary:
This is a Phase II/III, randomized, double-blind, parallel group, placebo controlled, multicenter study to evaluate the safety and efficacy of rituximab in adults with PPMS. The study will enroll approximately 435 subjects at up to 60 sites in the United States and Canada.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: placebo intervention 2: rituximab
Intervention descriptions: intervention 1: Intravenous repeating dose intervention 2: Intravenous repeating dose

Protocol document: