Conditions: Depressive Disorder, Major
Keywords: MDD Major Depressive Disorder Depression
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 638

Brief summary:
The primary purpose of this study is to evaluate the efficacy and safety of two doses of DVS SR (50 and 100 mg/day) in the treatment of adults with Major Depressive Disorder.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None arm 4: Active control to assess assay sensitivity

Interventions: intervention 1: Desvenlafaxine Succinate Sustained-Release (DVS SR) intervention 2: Desvenlafaxine Succinate Sustained-Release (DVS SR) intervention 3: Placebo intervention 4: Duloxetine 60 mg/day
Intervention descriptions: intervention 1: 50 mg tablet, once daily dosing for 8 weeks intervention 2: 100 mg tablet, once daily dosing for 8 weeks intervention 3: Matching placebo tablets and capsules, once daily dosing for 8 weeks intervention 4: 60 mg capsule, once daily dosing for 8 weeks

Protocol document: