Conditions: Diabetes Mellitus, Type 2
Keywords: Type 2 diabetes mellitus Glucose dependent insulinotropic polypeptide Sulfonylurea compounds insulin secretion Sulfonylurea receptor subunit-SUR1 Impaired incretin effect
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 12
Healthy volunteers: no

Brief summary:
The investigators hypothesize that the impaired insulinotropic effect of the incretin hormone GIP may be due to inadequate sensitization and ATP induced closure of beta cell K-ATP channels. By closing the channels through the use of sulfonylurea (SU) we hope to restore the insulinotropic effect of GIP.

Detailed description:

Arms:

Interventions: intervention 1: Sulfonylurea
Intervention descriptions: intervention 1: None

Protocol document: