Conditions: Asthma
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 1640
Healthy volunteers: no

Brief summary:
This is a multicenter study to evaluate the efficacy and safety of MK0476 versus placebo in participants with chronic asthma who actively smoke cigarettes.

Detailed description:

Arms:
arm 1: Arm 1: Montelukast arm 2: Arm 2: Fluticasone arm 3: Arm 3: Placebo

Interventions: intervention 1: montelukast sodium intervention 2: Comparator: Placebo intervention 3: Comparator: fluticasone intervention 4: Comparator: Placebo
Intervention descriptions: intervention 1: montelukast 10 mg tablet once daily, 6 month treatment period intervention 2: fluticasone propionate 250 mcg Placebo (Pbo) twice daily, 6 month treatment period intervention 3: fluticasone propionate 250 mcg twice daily, 6 month treatment period intervention 4: montelukast 10 mg Pbo tablet once daily, 6 month treatment period

Protocol document: