Conditions: Constipation
Keywords: Constipation small intestinal bacterial overgrowth stool bacteria
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 25
Healthy volunteers: no

Brief summary:
Patients with constipation often have bloating and abdominal distension. It is unclear if this is related to intestinal bacteria. Hypothesis: treatment for constipation may reduce small bowel and colon bacteria colonization, a change in the balance of stool microorganisms, and improve the symptoms of dyspepsia and constipation.

Detailed description:
This is an open-label study to collect data on upper and lower GI symptoms, hydrogen breath test, stool PCR, and serum before and after 4 weeks of lubiprostone 24 mcg by mouth twice a day for 4 weeks.

Arms:
arm 1: Subjects receive lubiprostone and bacteria is measured before and after

Interventions: intervention 1: Lubiprostone
Intervention descriptions: intervention 1: 24 mcg bid for 28 days

Protocol document: