Conditions: Pain, Postoperative
Keywords: mastectomy pain, postoperative pregabalin
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 70
Healthy volunteers: no

Brief summary:
The investigators hypothesize that pregabalin will decrease post-operative pain scores and analgesic use following total mastectomy compared to placebo. The primary outcome will be acute postoperative pain, measured by a verbal numerical rating score (VNRS) and total analgesic consumption during postoperative 48 hours. The secondary outcome will be VNRS at 1 week and 1 month after operation.

Detailed description:

Arms:
arm 1: Patients receive oral Placebo 1 hour prior to surgery, and 12 hours later arm 2: Patients receive oral pregabalin 1 hour prior to surgery, and 12 hours later

Interventions: intervention 1: Pregabalin intervention 2: Vitamin Complex (placebo)
Intervention descriptions: intervention 1: Pregabalin 75 mg orally intervention 2: Vitamin Complex orally

Protocol document: