Conditions: Type 2 Diabetes Mellitus
Keywords: diabetes exenatide sitagliptin Amylin Lilly metformin thiazolidinedione
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 83
Healthy volunteers: no

Brief summary:
This study is designed to compare the short-term effects and mechanisms of action of exenatide with those of sitagliptin when either is added to an oral agent(metformin or a thiazolidinedione \[TZD\]) in adult patients with type 2 diabetes mellitus(T2DM) with inadequate glycemic control.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: exenatide intervention 2: sitagliptin intervention 3: placebo intervention 4: placebo
Intervention descriptions: intervention 1: subcutaneous injection (5mcg or 10mcg), twice a day intervention 2: oral administration (100mg), once a day in the morning intervention 3: subcutaneous injection (5mcg or 10mcg), twice a day intervention 4: oral administration (100mg), once a day in the morning

Protocol document: