Conditions: Epilepsy
Keywords: Epilepsy; Monotherapy Partial Onset Seizures Adults and Adolescents
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 62
Healthy volunteers: no

Brief summary:
Antiepileptic Drugs (AEDs) are the main treatment for epilepsy; however, only a limited number of AEDs are approved for use as monotherapy. The objective of this study is to evaluate the efficacy of BRV in the conversion of partial onset seizure patients from combination treatment to monotherapy.

Detailed description:

Arms:
arm 1: 50 mg daily arm 2: 100 mg daily

Interventions: intervention 1: Brivaracetam intervention 2: Brivaracetam
Intervention descriptions: intervention 1: 25 mg tablet - 50 mg daily for 17 weeks (or 21 weeks if down-titrated (50 mg \> 20 mg) for subjects not participating in the follow-up study) intervention 2: 25 mg tablet - 100 mg daily for 17 weeks (or 21 weeks if down-titrated (100 mg \> 50 mg \> 20 mg) for subjects not participating in the follow-up study)

Protocol document: