Conditions: Postoperative Nausea and Vomiting
Keywords: PONV nausea emesis antiemetics aprepitant ondansetron dexamethasone
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 115
Healthy volunteers: no

Brief summary:
We hypothesize that the combination of aprepitant with dexamethasone will provide significantly improved prophylaxis against Postoperative nausea and vomiting compared with the combination of ondansetron and dexamethasone, in patients undergoing craniotomy under general anesthesia.

Detailed description:

Arms:
arm 1: Aprepitant 40 mg preoperatively + dexamethasone 10 mg after induction of anesthesia arm 2: Ondansetron 4 mg within 30 min of the end of surgery + Dexamethasone 10 mg after induction of anesthesia

Interventions: intervention 1: Aprepitant + Dexamethasone intervention 2: Ondansetron + Dexamethasone
Intervention descriptions: intervention 1: Aprepitant 40 mg + Dexamethasone 10 mg intervention 2: Ondansetron 4 mg + Dexamethasone 10 mg

Protocol document: