Conditions: Hypertension
Keywords: Hypertension African American aliskiren hydrochlorothiazide systolic blood pressure diastolic blood pressure amlodipine stage 2
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 332
Healthy volunteers: no

Brief summary:
The purpose of the study is to evaluate the efficacy and safety of a fixed dose combination of aliskiren HCTZ versus amlodipine in African American patients with Stage 2 hypertension.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Aliskiren Hydrochlorothiazide (HCTZ): 8 weeks intervention 2: Amlodipine: 8 weeks
Intervention descriptions: intervention 1: Aliskiren HCTZ (150/12.5 mg) for 1 week followed by forced titration to Aliskiren HCTZ (300/25 mg) for remaining 7 weeks intervention 2: Amlodipine 5 mg for 1 week followed by forced titration to Amlodipine 10 mg for remaining 7 weeks

Protocol document: