Conditions: Tonsillitis
Keywords: Dexmedetomidine, fentanyl, tonsillectomy and adenoidectomy,
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 101
Healthy volunteers: yes

Brief summary:
The primary purpose of this study is:

1. To compare dexmedetomidine with fentanyl in terms of intra-operative hemodynamics and post-operative analgesia.
2. To determine an analgesic dose response relationship for dexmedetomidine.
3. Compare recovery characteristics of dexmedetomidine to fentanyl.

Detailed description:

Arms:
arm 1: Fentanyl 1 micrograms (mcg)/kilogram (kg) arm 2: Fentanyl 2 micrograms (mcg)/kilogram (kg) arm 3: Dexmedetomidine 2 micrograms (mcg)/kilogram (kg) arm 4: Dexmedetomidine 4 micrograms (mcg)/kilogram (kg)

Interventions: intervention 1: Fentanyl intervention 2: Fentanyl intervention 3: Dexmedetomidine intervention 4: Dexmedetomidine
Intervention descriptions: intervention 1: Fentanyl 1mcg/kg, Intravenous (IV) intervention 2: Fentanyl 2mcg/kg, Intravenous (IV) intervention 3: Dexmedetomidine, 2mcg/kg, Intravenous (IV) intervention 4: Dexmedetomidine, 4mcg/kg Intravenous (IV)

Protocol document: