Conditions: Alcoholism Alcohol Dependence Post-Traumatic Stress Disorder
Keywords: Alcoholism Alcohol Dependence Post-Traumatic Stress Disorder Naltrexone Cognitive Behavior Therapy
Allocation: RANDOMIZED | Intervention model: FACTORIAL
Enrollment: 165
Healthy volunteers: no

Brief summary:
This study will evaluate naltrexone and cognitive-behavioral therapy treatments for alcohol dependence and post-traumatic stress disorder (PTSD). Subjects will be randomly assigned a 6-month treatment of either: 1) naltrexone alone, 2) naltrexone with PTSD psychosocial therapy, 3) a placebo with PTSD psychosocial therapy, or 4) placebo alone. An enhanced medication management intervention will accompany all treatment conditions. Follow-up assessments will be completed at 9 and 12 months after treatment.

Detailed description:

Arms:
arm 1: Naltrexone alone arm 2: Naltrexone with CBT for PTSD arm 3: Placebo with CBT for PTSD arm 4: Placebo alone

Interventions: intervention 1: Cognitive-Behavioral Therapy intervention 2: Naltrexone intervention 3: Placebo
Intervention descriptions: intervention 1: Twelve weekly 90-minute individual therapy sessions followed by (6) 90-minute sessions every other week intervention 2: Daily dosing 100 mg for 24 weeks intervention 3: Pill Placebo daily dosing 24 weeks

Protocol document: