Conditions: Femoral Fractures
Keywords: Tranexamic Acid Blood Loss Long Bone Fracture Surgery
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 82
Healthy volunteers: no

Brief summary:
Tranexamic acid has been shown to reduce postoperative blood losses and transfusion requirements in a number of types of surgery. Most trials in orthopedic surgery have been conducted in arthroplasty, hip fracture and spine surgeries. This study would aim to see the effect of tranexamic acid in reduction of blood loss and transfusions for long bone fracture surgery, primarily fracture shaft of femur.

Detailed description:

Arms:
arm 1: Tranexamic Acid plus standard of care arm 2: Standard of care includes the routine surgical and anesthetic techniques being utilized to control blood loss.

Interventions: intervention 1: Tranexamic Acid plus standard of care intervention 2: Standard of care
Intervention descriptions: intervention 1: Tranexamic acid given slowly intravenously (15 mg/kg body weight) 15 minutes before surgery followed by a second dose at three hour interval from first dose and third dose at three hour interval from the second + Standard of care (Standard of care includes the routine surgical and anesthetic techniques being utilized to control blood loss) intervention 2: Standard of care includes the routine surgical and anesthetic techniques being utilized to control blood loss

Protocol document: