Conditions: Drug Induced Liver Injury
Keywords: acetaminophen protein adducts hepatic function drug safety non drinkers
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 35
Healthy volunteers: yes

Brief summary:
Acetaminophen is commonly used to treat fever or pain. Your body clears acetaminophen by processing it in the liver. During the processing, some of the acetaminophen may bind to proteins in the liver. The protein-acetaminophen product is called an "adduct." After a large acetaminophen overdose, the liver has to process a lot of acetaminophen, so large amounts of adducts are formed. However, we have found that lower levels may be formed even when people take recommended doses. The purpose of this study is to measure the amount of adducts formed when healthy people who do not drink alcohol take normal doses of acetaminophen for 10 days.

Detailed description:

Arms:
arm 1: all subjects receive 4 g/day of acetaminophen for 10 consecutive days in this open-label study

Interventions: intervention 1: acetaminophen
Intervention descriptions: intervention 1: 4 g/day for 10 consecutive days

Protocol document: