Conditions: Hypercholesterolemia, Dyslipidemia
Keywords: Hypercholesterolemia, Dyslipidemia, simvastatin, Zocor
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 31
Healthy volunteers: no

Brief summary:
The purpose of this study was to provide human lipidomics standards with simvastatin treatment that were to be used for comparison with similar preclinical studies.

Detailed description:

Arms:
arm 1: Simvastatin 40 mg tablets once daily for 2 weeks followed by placebo for 2 weeks arm 2: Placebo for 2 weeks followed by simvastatin 40 mg once daily for 2 weeks

Interventions: intervention 1: Simvastatin intervention 2: Placebo
Intervention descriptions: intervention 1: 40 mg once daily for 2 weeks intervention 2: Placebo, matching the simvastatin (40 mg) tablet as a single oral daily dose for 2 weeks

Protocol document: