Conditions: Major Depression Dysthymia Depressive Disorder Not Otherwise Specified
Keywords: Major Depression Dysthymia Depression Not Otherwise Specified Dichotic Listening Fluoxetine Imipramine Predictors
Allocation:  | Intervention model: SEQUENTIAL
Enrollment: 25
Healthy volunteers: no

Brief summary:
Depressed patients will have hearing tests and then be treated with up to three treatments (i.e., Fluoxetine, Imipramine) until remitted, to see whether test results predict specific outcomes.

Detailed description:
100 depressed patients will be tested with verbal and nonverbal dichotic tests, and then treated sequentially with Fluoxetine and Imipramine until remitted. Preferential hemisphere for auditory processing will be correlated with treatment outcome.

Arms:
arm 1: fluoxetine or Imipramine

Interventions: intervention 1: Fluoxetine intervention 2: Imipramine
Intervention descriptions: intervention 1: Phase 1: Fluoxetine: wk 1: 10 mg/day; wks 2-3: 20 mg/day; wks 4-5: 40 mg/day; wk 6: 60 mg/day; wks 7-12: 80 mg/day \*All increases only if tolerated. intervention 2: Phase 2: Imipramine wk 1: 25 mg/day; wk 2: 50 mg/day; wk 3: 100 mg/day, 150 mg/day after 3 days; wk 4: 200 mg/day, 250 mg/day after 3 days; wks 5-6: 300 mg/day. \*All increases only if tolerated.

Protocol document: