Conditions: Breast Cancer
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 6
Healthy volunteers: no

Brief summary:
This study aim was to determine the safety and efficacy of R1507 in combination with letrozole in patients with advanced breast cancer. In the first part of the study a cohort of patients with advanced breast cancer received letrozole 2.5mg po daily in combination with R1507 16mg/kg every 3 weeks.

Detailed description:

Arms:
arm 1: Participants received a full daily dose of 2.5 mg of orally administered Letrozole along with 16 mg/kg of intravenous R1507 administered q3w, and observed for dose limiting toxicity for the first 2 cycles of treatment.

Interventions: intervention 1: RG1507 intervention 2: Letrozole
Intervention descriptions: intervention 1: R1507 was administered at a dose 16 mg/kg every 3 weeks. intervention 2: Letrozole was administered orally at a dose 2.5 mg daily.

Protocol document: