Conditions: Osteoporosis
Keywords: arthritis & connective tissue diseases idiopathic juvenile osteoporosis rare disease
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 10
Healthy volunteers: no

Brief summary:
OBJECTIVES:

I. Determine the effects of alendronate sodium on skeletal remodeling and bone mineral density of the hip and spine in children with high-turnover idiopathic juvenile osteoporosis.

Detailed description:
PROTOCOL OUTLINE:

Patients receive oral alendronate sodium weekly for 1 year. Treatment continues in the absence of disease progression or unacceptable toxicity.

Arms:
arm 1: Ten children will take alendronate 35mg or 70mg weekly depending upon the body weight for 12 months. Patients will also take calcium supplement daily.

Interventions: intervention 1: Alendronate
Intervention descriptions: intervention 1: Pill, 35mg or 70mg weekly, depending upon the body weight for 12 months.

Protocol document: