Conditions: Anesthesia, General
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 198
Healthy volunteers: no

Brief summary:
The purpose of this study was to demonstrate in adult participants faster recovery from a neuromuscular block induced by either rocuronium or vecuronium after reversal at reappearance of T2 (the amplitude of the first response of second twitch to train of four (TOF) stimulation, expressed as percentage of control first twitch, T1) by 2.0 mg/kg sugammadex (Org 25969) compared to 50 ug/kg neostigmine.

Detailed description:

Arms:
arm 1: After the last dose of rocuronium, at reappearance of T2, a dose of 2.0 mg/kg sugammadex was administered arm 2: After the last dose of rocuronium, at reappearance of T2, a dose of 50 ug/kg neostigmine was administered arm 3: After the last dose of vecuronium, at reappearance of T2, a dose of 2.0 mg/kg sugammadex was administered arm 4: After the last dose of vecuronium, at reappearance of T2, a dose of 50 ug/kg neostigmine was administered

Interventions: intervention 1: Sugammadex intervention 2: Neostigmine
Intervention descriptions: intervention 1: After the last dose of rocuronium or vecuronium, at reappearance of T2, a dose of 2.0 mg/kg sugammadex was to be administered intervention 2: After the last dose of rocuronium or vecuronium, at reappearance of T2, a dose of 50 ug/kg neostigmine was to be administered

Protocol document: