Conditions: Biological Availability
Keywords: Single dose bioavailability study of methylprednisolone powder for oral suspension (4mg/mL) versus methylprednisolone tablet (32 mg)
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 24
Healthy volunteers: yes

Brief summary:
A new formulation of methylprednisolone is being developed. A study is needed to determine the drug availability using the new formulation, a powder for reconstitution into a suspension, versus the current commercially available tablet formulation in healthy volunteers.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None

Interventions: intervention 1: methylprednisolone intervention 2: methylprednisolone intervention 3: methylprednisolone
Intervention descriptions: intervention 1: powder for oral suspension 4 mg/mL single dose (8 mL) intervention 2: powder for oral suspension 4 mg/mL singe dose (8 ml) intervention 3: tablet 32 mg single dose

Protocol document: