Conditions: Sinusitis Bacterial Infections
Keywords: Treatment of acute bacterial rhinosinusitis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 293
Healthy volunteers: no

Brief summary:
This is a clinical study organized to collect clinical data to better define the activity of some antimicrobials already marketed in Italy and in the rest of the world for the treatment of acute bacterial rhinosinusitis

Detailed description:

Arms:
arm 1: Moxifloxacin (Avelox, BAY12-8039) 400 mg tablets once daily (OD) for 7 days and amoxicillin/clavulanate 1000 mg matching placebo tablets three times daily (TID)for 10 days arm 2: Amoxicillin/clavulanate 1000 mg tablets three times daily (TID) for 10 days and moxifloxacin 400 mg matching placebo tablets once daily (OD) for 7 days

Interventions: intervention 1: Moxifloxacin (Avelox, BAY12-8039) intervention 2: Amoxicillin/Clavulanate
Intervention descriptions: intervention 1: Patients will be administered daily a single moxifloxacin 400 mg tablet for 7 days intervention 2: Patient will be administered daily Amoxicilline/Clavulanate 1000 mg tablets every 8 hours for 10 days

Protocol document: