Conditions: Atherosclerosis
Keywords: vascular inflammation endothelium-dependent flow-mediated blood vessel function
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 58
Healthy volunteers: yes

Brief summary:
The purpose of this study is to determine whether reducing inflammation in blood vessels with an aspirin-like drug called salsalate will improve blood vessel function.

Detailed description:
To test the hypothesis that inhibition of I \[kappa\] B kinase \[beta\] (IĸKβ), an inflammatory mediator, by high dose salsalate, will restore insulin-mediated endothelium-dependent vasodilation in subjects with atherosclerosis.

Arms:
arm 1: In this crossover study, this group was randomly allocated therapy with salsalate first, a 4 week washout, then 4 weeks of placebo therapy in a double-blinded fashion. arm 2: In this crossover study, this group was randomly allocated therapy with placebo first, a 4 week washout, then 4 weeks of salsalate therapy in a double-blinded fashion.

Interventions: intervention 1: salsalate intervention 2: placebo
Intervention descriptions: intervention 1: 1.5 grams orally 3 times daily intervention 2: matching placebo

Protocol document: