Conditions: Healthy Volunteers
Keywords: QT/QTc
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 83
Healthy volunteers: yes

Brief summary:
To assess the effect of immediate-release guanfacine hydrochloride, administered at therapeutic and supratherapeutic doses, on QT/QTc in healthy normal males and females

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None

Interventions: intervention 1: immediate release guanfacine hydrochloride intervention 2: moxifloxacin intervention 3: Placebo
Intervention descriptions: intervention 1: Subjects will receive 2x2mg immediate-release guanfacine on day 1. Subjects will receive 4x2mg immediate-release guanfacine on day 6. intervention 2: Subjects will receive 400mg of moxifloxacin on day 1. Subjects will receive 400mg of moxifloxacin on day 6. intervention 3: Subjects will receive placebo on Day 1. Subjects will receive placebo on Day 6.

Protocol document: