Conditions: Acute Myocardial Infarction ST Elevation MI STEMI
Keywords: INOT44 NOMI
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 29
Healthy volunteers: no

Brief summary:
The purpose of this study is to assess whether or not inhaled nitric oxide can decrease myocardial infarction (MI) size at 48-72 hours in patients presenting with an ST segment elevation MI (STEMI) who undergo successful percutaneous coronary intervention.

Detailed description:
The purpose of the trial is to assess whether or not inhaled nitric oxide can decrease myocardial infarction (MI) size as a fraction of left ventricular (LV) size at 48-72 hours in patients presenting with an ST segment elevation MI who undergo successful percutaneous coronary intervention (PCI).

The primary endpoint for this study will be myocardial infarction size as a fraction of left ventricular size at 48-72 hours as measured by contrast-enhanced cardiac MRI.

Arms:
arm 1: Inhaled Nitric oxide administered at 80 parts per million (ppm) arm 2: Inhaled nitrogen gas (Placebo) administered at 80 ppm

Interventions: intervention 1: Nitric Oxide intervention 2: Placebo
Intervention descriptions: intervention 1: Nitric oxide for inhalation intervention 2: Nitrogen gas (placebo) for inhalation

Protocol document: