Conditions: Septic Shock
Keywords: Septic shock Acetyl-L-carnitine
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 13
Healthy volunteers: no

Brief summary:
This placebo-controlled study investigates acetyl-L-carnitine in the treatment of septic shock requiring vasopressors.

Detailed description:
This is a cross-over study which infuses ALC for 12 out of 18 hours (and placebo the other 6). Patients must have vasopressor-dependent septic shock and be free from renal failure, hepatic failure, and seizures to be eligible.

Arms:
arm 1: Placebo for first 6 hours then Acetyl-L-Carnitine (ALC) for 12 hours arm 2: Acetyl-L-Carnitine (ALC) for first 12 hours then placebo for next 6 hours

Interventions: intervention 1: Acetyl-L-Carnitine
Intervention descriptions: intervention 1: Acetyl-L-Carnitine - 4 g IV over 30 minutes, then 8 g iv over the next 12 hours

Protocol document: