Conditions: Insomnia
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 21
Healthy volunteers: yes

Brief summary:
The purpose of this study is to determine the effect of activated charcoal and dosing time on the absorption of LY2624803 in healthy subjects. In this crossover study, there are three treatments with a washout period of at least 7 days in between treatments. Each subject will participate in all three treatments with random assignment to the treatment sequence.

Detailed description:

Arms:
arm 1: Participants received 6 milligrams (mg) LY2624803 alone orally (po) at approximately 0800 hours following an overnight fast. arm 2: Participants received 6 mg LY2624803 po at approximately 0800 hours following an overnight fast, followed 1 hour later by a single po dose of 1 gram per kilogram (g/kg) body weight of activated charcoal, mixed with caffeine-free diet cola. arm 3: Participants received 6 mg LY2624803 alone po at approximately 2200 hours following a 4-hour fast.

Interventions: intervention 1: LY2624803 intervention 2: Activated Charcoal
Intervention descriptions: intervention 1: Administered orally (po), once. intervention 2: Administered po

Protocol document: