Conditions: Diabetes Mellitus, Type 2
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 23
Healthy volunteers: no

Brief summary:
The primary objective of the study is to investigate the effect of BI 10773, hydrochlorothiazide and torasemide on changes in serum and urine electrolytes. Furthermore the pharmacodynamic and pharmacokinetic interactions between BI 10773 and diuretics should be assessed.

Detailed description:

Arms:
arm 1: administration of BI 10773 once daily for 5 days (20 patients) arm 2: administration of hydrochlorothiazide (HTC) once daily for 4 days (10 patients) arm 3: administration of torasemide (TOR) once daily for 4 days (10 patients) arm 4: administration of BI 10773 + HTC once daily for 5 days (10 patients) arm 5: administration of BI 10773 + TOR once daily for 5 days (10 patients)

Interventions: intervention 1: BI 10773 intervention 2: hydrochlorothiazide intervention 3: torasemide intervention 4: BI 10773 intervention 5: torasemide intervention 6: BI 10773 intervention 7: hydrochlorothiazide
Intervention descriptions: intervention 1: multiple oral doses intervention 2: multiple oral doses intervention 3: multiple oral doses intervention 4: multiple oral doses intervention 5: multiple oral doses intervention 6: multiple oral doses intervention 7: multiple oral doses

Protocol document: