Conditions: Pulmonary Arterial Hypertension
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 130
Healthy volunteers: no

Brief summary:
To demonstrate a dose response for 1 mg, 5 mg and 20 mg TID oral sildenafil for the treatment of subjects with PAH.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None arm 4: Open label extension from week 12 to week 24.

Interventions: intervention 1: Sildenafil citrate intervention 2: Sildenafil citrate intervention 3: Sildenafil citrate intervention 4: Sildenafil citrate
Intervention descriptions: intervention 1: oral, 20 mg, tid intervention 2: oral 1 mg, tid intervention 3: oral 5 mg, tid intervention 4: oral 20 mg, tid

Protocol document: