Conditions: Type 2 Diabetes Mellitus
Keywords: Type 2 Diabetes Mellitus Saxagliptin Randomised Double-blind
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 286
Healthy volunteers: no

Brief summary:
The study will evaluate the efficacy and tolerability of saxagliptin compared to uptitration of metformin in patients with type 2 diabetes who have inadequate glycaemic control on a submaximal dose of metformin.

Detailed description:

Arms:
arm 1: Saxagliptin 5 mg arm 2: Metformin 500 -1000 mg

Interventions: intervention 1: Saxagliptin intervention 2: Metformin
Intervention descriptions: intervention 1: 5 mg, oral tablet, once daily intervention 2: 500 mg, oral tablet, 1 or 2 additional tablets per day added to background therapy

Protocol document: