Conditions: Hyponatremia Euvolemia Hypervolemia
Keywords: Hyponatremia Euvolemia Hypervolemia Conivaptan Vaprisol® YM087
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 121
Healthy volunteers: no

Brief summary:
The study will evaluate the effectiveness and safety of multiple dosing regimens of IV conivaptan in subjects with euvolemic or hypervolemic hyponatremia

Detailed description:

Arms:
arm 1: Placebo loading dose + 20mg/day continuous infusion conivaptan per ampoule arm 2: Conivaptan loading dose (20mg)+ 20mg/day continuous infusion conivaptan per ampoule arm 3: Placebo loading dose + 20mg/day continuous infusion conivaptan per premix bag arm 4: Conivaptan loading dose (20mg) + 20mg/day continuous infusion conivaptan per premix bag

Interventions: intervention 1: Conivaptan intervention 2: placebo
Intervention descriptions: intervention 1: ampoule or premix bag intervention 2: ampoule or premix bag

Protocol document: