Conditions: Hypertension
Keywords: Hypertension Beta-blockers Ambulatory blood pressure Basal metabolic rate Quality of life
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 1
Healthy volunteers: no

Brief summary:
The purpose of the study is to compare the effects of nebivolol and metoprolol on 24-hour ambulatory blood pressure characteristics and basal metabolic rates in patients with hypertension.

Detailed description:

Arms:
arm 1: metoprolol 25-200mg at a stable daily dose for 4 weeks, then change to nebivolol at a comparable stable dose (5-20 mg) for 4 -5 weeks.

Interventions: intervention 1: Metoprolol intervention 2: Nebivolol
Intervention descriptions: intervention 1: Metoprolol tablets 25-200 mg daily times four weeks. Nebivolol daily for 4-5 weeks intervention 2: 5 - 20 mg daily, at a stable dose for 4 to 5 weeks

Protocol document: