Conditions: Type 2 Diabetes Mellitus
Keywords: diabetes exenatide exenatide once weekly metformin sulfonylurea insulin glargine Amylin Lilly
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 467
Healthy volunteers: no

Brief summary:
The purpose of this study is to compare the effects of 2.0 mg exenatide once weekly and insulin glargine, titrated to glucose targets using the algorithm described by Yki- Järvinen et al.(2007), with respect to glycemic improvements, body weight, fasting lipids, safety, and tolerability.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Exenatide Once Weekly intervention 2: Insulin Glargine
Intervention descriptions: intervention 1: subcutaneous injection, 2.0mcg, once weekly intervention 2: subcutaneous injection, variable dose, QD

Protocol document: