Conditions: Cocaine Abuse
Keywords: disulfiram cognitive behavioral therapy contingency management drug abuse therapy educational/resource design/development
Allocation: RANDOMIZED | Intervention model: FACTORIAL
Enrollment: 181
Healthy volunteers: yes

Brief summary:
This is a study of four treatments for chronic cocaine use and may help study participants to control their drug use. All participants will receive weekly individual cognitive behavioral therapy (CBT).

Detailed description:
This study will compare four types of treatment involving skills training and incentives for attending sessions or taking study medication. Disulfiram is a widely prescribed deterrent to alcohol use. In addition to weekly cognitive behavioral therapy (CBT), participants will be assigned to one of the following treatments:

1. placebo
2. disulfiram
3. placebo plus incentives for cocaine abstinence and medication compliance (prize CM)
4. disulfiram plus incentives for cocaine abstinence and medication compliance

Arms:
arm 1: Placebo (plus Cognitive Behavioral Therapy- CBT) arm 2: Disulfiram (plus CBT) arm 3: Placebo plus Contingency Management for cocaine abstinence and medication compliance (in addition to CBT). arm 4: Disulfiram plus Contingency Management for cocaine abstinence and medication compliance (in addition to CBT).

Interventions: intervention 1: disulfiram intervention 2: Placebo intervention 3: Placebo plus Contingency Management intervention 4: Disulfiram plus Contingency Management
Intervention descriptions: intervention 1: 250mg per day of Disulfiram plus CBT intervention 2: Placebo plus CBT intervention 3: Placebo plus Contingency Management for cocaine abstinence and medication compliance in addition to CBT intervention 4: 250mg of Disulfiram plus Contingency Management for cocaine abstinence and medication compliance plus CBT.

Protocol document: