Conditions: Venous Thromboembolism Deep Vein Thrombosis Total Knee Arthroplasty
Keywords: prevention venous thromboembolism edoxaban factor Xa
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 523
Healthy volunteers: no

Brief summary:
The objective of this study is to assess the efficacy, safety and dose-response relationship of DU-176b compared with placebo for the prevention of venous thromboembolism in patients after elective total knee arthroplasty.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None arm 4: None arm 5: None

Interventions: intervention 1: DU-176b intervention 2: DU-176b intervention 3: DU-176b intervention 4: DU-176b intervention 5: Placebo
Intervention descriptions: intervention 1: DU-176b 5mg tablets oral, once daily for 2 weeks intervention 2: DU-176b 15mg tablets, oral once daily for 2 weeks intervention 3: DU-176b 30 mg tablets, oral, once daily for 2 weeks intervention 4: DU-176b 60 mg tablets, oral, once daily for 2 weeks intervention 5: Matching placebo oral tablets, once daily for 2 weeks

Protocol document: