Conditions: Solid Cancers
Keywords: Hedgehog BCC basal cell carcinoma
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 67
Healthy volunteers: no

Brief summary:
This is a two stage, Phase Ib study designed to describe the pharmacokinetics of GDC-0449 in patients with advanced solid tumors that are refractory to treatment or for whom no standard therapy exists.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None

Interventions: intervention 1: GDC-0449 intervention 2: GDC-0449 intervention 3: GDC-0449
Intervention descriptions: intervention 1: Daily oral repeating dose intervention 2: Three times weekly oral repeating dose intervention 3: Once weekly oral repeating dose

Protocol document: