Conditions: Hypercholesterolemia
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 196
Healthy volunteers: no

Brief summary:
The purpose of this study is to evaluate and compare the efficacy and safety of ezetimibe plus atorvastatin versus atorvastatin in hypercholesterolemic patients at moderately high risk for coronary heart disease not adequately controlled on atorvastatin 20 mg.

Detailed description:

Arms:
arm 1: Atorvastatin 40mg tablet + Atorvastatin 20mg Pbo and ezetimibe 10mg Pbo tablets po qd (by mouth, once a day). arm 2: Atorvastatin 40mg Pbo tablet + Atorvastatin 20mg and ezetimibe 10mg tablets po qd (by mouth, once a day).

Interventions: intervention 1: Comparator: atorvastatin intervention 2: Comparator: Placebo intervention 3: Comparator: ezetimibe intervention 4: Comparator: Placebo.
Intervention descriptions: intervention 1: Atorvastatin 40mg tablet po qd (by mouth, once a day) for 6 weeks intervention 2: Atorvastatin 20mg Pbo and ezetimibe 10mg Pbo tablets po qd (by mouth, once a day). for 6 weeks intervention 3: Atorvastatin 20mg and ezetimibe 10mg tablets po qd (by mouth, once a day). for 6 weeks. intervention 4: Atorvastatin 40mg Pbo tablets po qd (by mouth, once a day). for 6 weeks.

Protocol document: