Conditions: Alzheimer's Disease
Keywords: Alzheimer's disease cognition SB-742457
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 682
Healthy volunteers: no

Brief summary:
The study is designed to investigate the safety and efficacy of SB-742457 when added to stable donepezil treatment in subjects with mild-to-moderate Alzheimer's disease.

Detailed description:

Arms:
arm 1: SB-742457 - 15mg added to existing donepezil treatment arm 2: Placebo added to existing donepezil arm 3: SB-742457 - 35mg added to existing donepezil

Interventions: intervention 1: SB-742457 15mg intervention 2: SB-742457 35mg intervention 3: Placebo intervention 4: donepezil 5-10mg
Intervention descriptions: intervention 1: SB-742457 - 15mg added to existing donepezil treatment intervention 2: SB-742457 - 35mg added to existing donepezil intervention 3: Placebo added to existing donepezil intervention 4: existing donepezil treatment

Protocol document: