Conditions: Elevated Prostate Specific Antigen
Keywords: Men with Elevated PSA
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 85
Healthy volunteers: no

Brief summary:
The purpose of this study is to assess the impact of an empiric course of antibiotics for men with an elevated prostate-specific antigen (PSA) level.

Detailed description:
Study Objectives:

Primary Objective: To assess the impact of ciprofloxacin on the change in PSA from baseline/randomization to prostate biopsy

Secondary Objective: To assess the impact of ciprofloxacin on the overall infectious complications following prostate biopsy

The impact of observation versus ciprofloxacin on PSA levels will be assessed by PSA change from baseline. The first PSA measurement will be at the study entry and randomization. The second PSA measurement will be immediately prior to prostate biopsy, which will occur 21-45 days following randomization.

Arms:
arm 1: Observation only for 2 weeks arm 2: Ciprofloxacin 500 mg twice daily for 2 weeks

Interventions: intervention 1: Ciprofloxacin
Intervention descriptions: intervention 1: None

Protocol document: