Conditions: Hypertension
Keywords: nebivolol Bystolic ™ lisinopril losartan Hypertension
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 491
Healthy volunteers: no

Brief summary:
This study will assess blood pressure reduction with nebivolol or placebo in patients taking lisinopril or losartan.

Detailed description:

Arms:
arm 1: Nebivolol 5 mg, 5 mg nontrade tablets, oral administration Nebivolol 10 mg, 10 mg nontrade tablets, oral administration Nebivolol 20 mg, 20 mg nontrade tablets, oral administration Nebivolol 40 mg (two 20 mg nontrade tablets), oral administration arm 2: Matching placebo tablets, oral administration

Interventions: intervention 1: nebivolol intervention 2: Placebo
Intervention descriptions: intervention 1: Encapsulated Nebivolol 5mg, 10mg, 20mg, or 40mg total daily dosage, oral administration once daily

Lisinopril 10mg, 20mg total daily dosage, oral administration Losartan 50mg, 100mg total daily dosage, oral administration intervention 2: Lisinopril 10mg, 20mg total daily dosage, oral administration Losartan 50mg, 100mg total daily dosage, oral administration

Protocol document: