Conditions: Heart Failure CHF
Keywords: Heart Failure Congestive Heart Failure CHF
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 36
Healthy volunteers: no

Brief summary:
The purpose of this study is to assess the ability of Ultrafiltration to influence the rate of hemodynamic improvement, as measured by the decline in the pulmonary artery occlusion pressure, in patients with NYHA class III/IV Heart Failure.

Detailed description:
This study will be preformed in a specialized heart failure unit at the Cleveland Clinic Foundation (CCF) and will include both the UF-treated group and a control group receiving usual and customary care. Patients will be stratified according to renal function at the time of admission. Therapies will be guided by specific hemodynamic criteria routinely used at the study institution.

Arms:
arm 1: Patients treated with Extracorporeal Ultrafiltration upon hospital admission for treatment of decompensated heart failure. arm 2: Patients treated with conventional diuretic therapy upon hospital admission for treatment of decompensated heart failure.

Interventions: intervention 1: IV loop diuretic intervention 2: NxStage System One
Intervention descriptions: intervention 1: Use of conventional diuretic therapy upon hospital admission for treatment of decompensated heart failure. intervention 2: Patients treated with Extracorporeal Ultrafiltration upon hospital admission for treatment of decompensated heart failure.

Protocol document: