Conditions: Rhinitis, Allergic, Seasonal
Keywords: Proof of concept
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 54
Healthy volunteers: no

Brief summary:
This is a randomised, double-blind, placebo-controlled 4-period cross-over study to assess the efficacy and safety of repeat dose intranasal GSK1004723 (1000µg), oral GSK835726 (10mg) and cetirizine (10mg) in the environmental challenge chamber in subjects with seasonal allergic rhinitis.

Detailed description:

Arms:
arm 1: 10mg oral dose arm 2: 1000mcg nasal spray solution arm 3: 10mg cetirizine as active comparator arm 4: placebo

Interventions: intervention 1: GSK835726 10mg intervention 2: GSK1004723 1000mcg intervention 3: Cetirizine 10mg intervention 4: placebo
Intervention descriptions: intervention 1: GSK835726 10mg tablet intervention 2: GSK1004723 1000mcg nasal spray solution intervention 3: Cetirizine 10mg active comparator intervention 4: placebo to match actives

Protocol document: