Conditions: Asthma
Keywords: Bronchodilator
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 15
Healthy volunteers: no

Brief summary:
Study to determine the bronchodilatory effects of PF-04191834 compared with zileuton in patients with asthma

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None arm 4: None arm 5: None

Interventions: intervention 1: PF-04191834 intervention 2: PF-04191834 intervention 3: PF-04191834 intervention 4: zileuton intervention 5: Placebo
Intervention descriptions: intervention 1: 30mg PF-04191834, single dose, oral dispersion + 2 x placebo tablets. intervention 2: 100mg PF-04191834, single dose, oral dispersion + 2 x placebo tablets, single dose. intervention 3: 2000mg PF-04191834, single dose, oral dispersion + 2 x placebo tables, single dose intervention 4: 1200mg, 2 x 600mg tablets, single dose + placebo oral dispersion, single dose. intervention 5: 2 x placebo tablets + placebo oral dispersion, single dose.

Protocol document: