Conditions: Healthy
Keywords: PK profile in Japanese healthy male volunteers
Allocation:  | Intervention model: PARALLEL
Enrollment: 18
Healthy volunteers: yes

Brief summary:
The purpose of this study is to investigate the pharmacokinetics of single doses of PF-02341066 (150, 250, and 400 mg) in the fasted condition in Japanese healthy male volunteers.

Detailed description:
The purpose of this study is to investigate the pharmacokinetics of single doses of PF-02341066 (150, 250, and 400 mg) in the fasted condition in Japanese healthy male volunteers.

Arms:
arm 1: This study will consist of three cohorts: PF-02341066 150 mg treatment group (n = 6), PF-02341066 250 mg treatment group (n = 6) and PF-02341066 400 mg treatment group (n = 6).

Interventions: intervention 1: PF-02341066 intervention 2: PF-02341066 intervention 3: PF-02341066
Intervention descriptions: intervention 1: Cohort 1: a 150 mg single dose of PF-02341066 administered as 1 x 50 mg IRT and 1 x 100 mg IRT. intervention 2: Cohort 2: a 250 mg single dose of PF-02341066 administered as 1 x 50 mg IRT and 2 x 100 mg IRTs. intervention 3: Cohort 3: a 400 mg single dose of PF-02341066 administered as 4 x 100 mg IRTs.

Protocol document: