Conditions: Cataracts
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 126
Healthy volunteers: yes

Brief summary:
Approximately 126 subjects scheduled to undergo cataract surgery by phacoemulsification, will be randomized in an even allocation (1:1:1) to either Acuvail, Xibrom or Nevanac. Subjects will be instructed to begin dosing the study medication in the operative eye the day before surgery and continue dosing on the day of surgery. Beginning one hour before surgery 1 drop of study medication will be instilled by operating room staff approximately every 15 minutes for a total of 3 doses. At the designated time a paracentesis will be performed at the start of the cataract procedure and at least 0.15cc of aqueous humor will be collected. The sample will be immediately stored on dry ice and shipped to a laboratory for analysis.

Detailed description:

Arms:
arm 1: Xibrom to be given 1 drop 2 times (BID) the day before surgery and 3 doses pre op the day of surgery prior to surgery arm 2: Nevanac to be given 1 drop 2 times (BID) the day before surgery and 3 doses pre op the day of surgery prior to surgery arm 3: Acuvail to be given preoperatively. One drop 2 times (BID), 1 day pre op and day of surgery 3 doses prior to surgery.

Interventions: intervention 1: Ketorolac Tromethamine intervention 2: Bromfenac intervention 3: nepafenac
Intervention descriptions: intervention 1: ketorolac to be given 1 drop BID the day before surgery and 3 doses pre op the day of surgery prior to surgery intervention 2: Drug to be given 1 drop BID the day before surgery and 3 doses pre op the day of surgery prior to surgery intervention 3: drug to be given 1 drop BID the day before surgery and 3 doses pre op the day of surgery prior to surgery

Protocol document: