Conditions: Polycystic Ovary Syndrome PCOS Insulin Sensitivity
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 28
Healthy volunteers: yes

Brief summary:
The purpose of this research study is to determine if adding Metformin, a drug that reduces insulin resistance, to birth control pills will reduce the risk of developing type 2 diabetes, high blood pressure. high lipid levels and heart disease in women with PCOS

Detailed description:
Inclusion criteria: PCOS women between the ages of 18-45,\< 8 periods annually, elevated serum free testosterone, normal thyroid function tests and serum prolactin, exclusion of late onset adrenal hyperplasia, acceptable health based on interview and medical history, physical exam and lab tests, ability to comply with the requirements of the study and to provide signed, witnessed informed consent.

Arms:
arm 1: Placebo tablet and birth control pill daily arm 2: metformin 2000 mg and birth control pill daily

Interventions: intervention 1: placebo intervention 2: metformin
Intervention descriptions: intervention 1: placebo birth control pill daily intervention 2: 2000 mg per day for 3 months daily birth control pill

Protocol document: