Conditions: Congenital Heart Disease
Keywords: Cardiopulmonary Bypass ACE inhibitor Pediatrics
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 21
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine whether ACE inhibitors alter the fibrinolytic, inflammatory, and hemodynamic response to cardiopulmonary bypass in infants and children with congenital heart disease.

Detailed description:

Arms:
arm 1: Patients already on an ACE inhibitor will continue it until the day of surgery arm 2: Patients on ACE inhibitors who are randomized to stop their ACE inhibitor 48 hours prior to surgery

Interventions: intervention 1: Angiotensin Converting Enzyme Inhibitor intervention 2: No ACE Inhibitor
Intervention descriptions: intervention 1: Patients randomized to this group will continue their current dose of ACE inhibitors until surgery intervention 2: Patients randomized to this group will stop their ACE inhibitors 48 hours before surgery

Protocol document: