Conditions: Candidemia Invasive Candidiasis
Keywords: Open-label non-comparative study to evaluate short course of IV anidulafungin followed by oral voriconazole for tx of candidemia/invasive candidiasis.
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 54
Healthy volunteers: no

Brief summary:
The primary objective is to estimate global response rate. Clinical, microbiological and global response rates and its 95% confidence intervals will be computed. No hypotheses will be tested.

Detailed description:

Arms:
arm 1: None

Interventions: intervention 1: Anidulafungin intervention 2: Voriconazole
Intervention descriptions: intervention 1: All patients will receive anidulafungin 200 mg IV dose on Day 1. On Day 2 and daily thereafter the patients will receive one daily IV dose of 100 mg of anidulafungin. intervention 2: Patients who complete a minimum of 5 days of IV treatment with anidulafungin may be switched to oral voriconazole 200 mg BID (or 100 mg BID if \<40 kg body weight) therapy on Day 5 and thereafter, starting with a loading dose of 400 mg BID (or 200 mg BID if \<40 kg body weight).

Protocol document: