Conditions: Postoperative Wound Infection
Keywords: Prevention Antiseptic Preoperative Scrub Postoperative Wound Infection
Allocation: RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 849
Healthy volunteers: no

Brief summary:
Most cases of infection of clean-contaminated wounds (wounds without gross spillage of organisms from the gastrointestinal tract) are thought to originate from the skin. Therefore, it is conceivable that application of an optimal antiseptic agent can reduce the rate of surgical wound infections. This trial is to compare the impact of disinfecting the skin with Chloraprep (2%chlorhexidine and 70% isopropyl alcohol) vs. Betadine on the rates of infection of clean-contaminated surgical wounds. The study will also assess the occurrence of adverse effects on the skin from either antiseptic agent and the cost-savings associated with the use of Chloraprep vs Betadine.

Detailed description:
This is a prospective, randomized, multicenter clinical trial. All adult patients, who are scheduled for a clean-contaminated surgical procedure of the alimentary, respiratory, reproductive or urinary tract will be asked to participate.

Arms:
arm 1: preoperative skin preparation with povidone-iodine arm 2: preoperative skin preparation with scrub and paint technique

Interventions: intervention 1: chlorhexidine-alcohol intervention 2: Povidone-Iodine
Intervention descriptions: intervention 1: Preoperative skin preparation with scrub and paint technique intervention 2: preoperative skin preparation with scrub and paint technique

Protocol document: