Conditions: Indigestion
Keywords: Epigastric Pain Non-Ulcer Dyspepsia (NUD)
Allocation: RANDOMIZED | Intervention model: FACTORIAL
Enrollment: 73
Healthy volunteers: no

Brief summary:
Inhibition of gastric acid is the key to satisfactory relief of symptoms with esomeprazole in NUD patients

Detailed description:
Enrolled patients will undergo 24h gastric pH monitoring and subsequently (if gastric pH drops below pH 4 during 24h monitoring) will be randomized to receive placebo (40 mg QD) or esomeprazole (40 mg QD) for 16 weeks of therapy. 24h gastric pH monitoring will be repeated 2nd and 3rd time in all participating patients at the end of 4th and 8th weeks of therapy. Additionally, in all participants NUD symptoms will be re-assessed at the end of 4th, 8th, 12th and 16th weeks of therapy.

Arms:
arm 1: Placebo arm 2: Esomeprazole

Interventions: intervention 1: Esomeprazole intervention 2: Placebo
Intervention descriptions: intervention 1: Esomeprazole 40 mg QD intervention 2: Placebo

Protocol document: