Conditions: Bacteremia
Keywords: Sodium citrate Gentamicin Prophylaxis Hemodialysis Central venous catheter
Allocation: RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 303
Healthy volunteers: no

Brief summary:
This is a randomized, double blinded, prospective, multicenter, clinical trial of the use of Heparin versus Gentamicin as a pos-dialysis catheter lock solution.

Detailed description:
The study is a randomized, double blinded, prospective, multicenter, clinical trial. All patients requiring vascular access with a tunneled central venous catheter for hemodialysis are eligible for enrollment. Patients will be randomized to receive either Heparin 1,000 U/ml in a volume sufficient to fill the catheter length in both ports or to receive 4% Sodium Citrate with Gentamicin 320 mcg/mL in a volume sufficient to fill the catheter length in both ports.We hypothesize that the device related infection rate in the Citrate/Gentamicin group will be less than the heparin arm.

Arms:
arm 1: Catheter lock with heparin 1,000 units/mL arm 2: Catheter lock with gentamicin 320 micrograms/mL in sodium citrate 4%

Interventions: intervention 1: Heparin 1000U/mL intervention 2: 4% Sodium Citrate with Gentamicin 320 mcg/mL
Intervention descriptions: intervention 1: A volume sufficient to fill the catheter length will be instilled in both catheter ports post dialysis intervention 2: A volume sufficient to fill the catheter length will be instilled in both catheter ports post dialysis

Protocol document: