Conditions: Locally Advanced Non-Small Cell Lung Cancer
Keywords: Proton Radiation
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 28
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine the effectiveness of proton beam radiotherapy combined with chemotherapy for treatment of locally advanced non-small cell lung cancer.

Detailed description:

Arms:
arm 1: Induction Chemotherapy - Two cycles Taxol 200mg/m2 and Carboplatin AUC6 on day 1 and day 22. Weekly chemotherapy concurrent with radiotherapy Taxol 50mg/m2 and Carboplatin AUC 2 weekly for 5 weeks.

Proton therapy - 76 Gy in 5 weeks to lung tumor.

Interventions: intervention 1: Proton Radiation Therapy intervention 2: Taxol intervention 3: Carboplatin
Intervention descriptions: intervention 1: A five week coarse of proton radiotherapy begins on day 28 and is given once daily for the first two weeks and twice daily for the final 3 weeks. The total dose given with proton beam is 76 Gy. Weekly chemotherapy with carboplatin and taxol is given during proton therapy. intervention 2: 200 mg/m2, IV, for 2 cycles followed by 50 mg/m2 weekly for 5 weeks during radiotherapy. intervention 3: AUC 6, IV, for two cycles followed by AUC 2 weekly for 5 weeks during radiotherapy.

Protocol document: