Conditions: Hypertension
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 941
Healthy volunteers: no

Brief summary:
This study will evaluate the efficacy and safety of the FDA approved blood pressure medication olmesartan medoxomil compared to the FDA approved medication losartan potassium.

Detailed description:

Arms:
arm 1: Olmesartan 20 mg once daily for four weeks followed by 40mg one daily for four weeks. arm 2: Placebo capsule of olmesartan once daily for 2 weeks, followed by olmesartan 20 mg once daily for two weeks, followed by olmesartan 40 mg for 4 weeks arm 3: Losartan 50 mg once daily for four weeks, followed by losartan 100 mg once daily for four weeks

Interventions: intervention 1: olmesartan medoxomil intervention 2: Placebo intervention 3: losartan potassium
Intervention descriptions: intervention 1: Oral tablets, once daily, at either 20mg or 40mg daily. intervention 2: placebo oral tablets once daily for two weeks intervention 3: losartan potassium oral tablet at either 50mg or 100 mg daily dose.

Protocol document: