Conditions: Peptic Ulcer
Keywords: aspirin peptic ulcer
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 178
Healthy volunteers: no

Brief summary:
Esomeprazole plus aspirin compared with esomeprazole alone for the treatment of aspirin-related peptic ulcers.

Detailed description:
The aims of this study are to compare esomeprazole plus aspirin with esomeprazole alone in the treatment of aspirin-related ulcers.

Patients with aspirin-related peptic ulcers are randomized to receive esomeprazole (40 mg/day) plus aspirin (100 mg/day) or esomeprazole (40 mg/day) alone for 8 weeks. Follow-up endoscopy was carried out at the end of the eighth week. The primary end point was the healing of peptic ulcers.

Arms:
arm 1: esomeprazole (40 mg/day) for 8 weeks arm 2: esomeprazole (40 mg/day) plus aspirin (100 mg/day) for 8 weeks

Interventions: intervention 1: aspirin
Intervention descriptions: intervention 1: aspirin, 100 mg, qd x 8 weeks

Protocol document: