Conditions: Schizophrenia Schizoaffective Disorder Bipolar Disorder
Keywords: schizophrenia antipsychotics diabetes bipolar disorder
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 24
Healthy volunteers: no

Brief summary:
Having a diagnosis of schizophrenia or bipolar disorder and being treated with certain of the newer antipsychotics are risk factors for development of diabetes. Subjects with these risk factors plus obesity and/or family history of diabetes who agree to study participation will undergo an oral glucose tolerance test. If the oral glucose tolerance test demonstrates that the subject is pre-diabetic (elevated glucose levels, but below the diabetic range), he/she will have his/her insulin resistance level measured, prior to random assignment to either stay on current antipsychotic medication or switch to ziprasidone. Insulin resistance will be measured again after four months. The primary hypothesis is that insulin resistance will decrease in those switched to ziprasidone relative to those continuing on their same antipsychotic medication.

Detailed description:

Arms:
arm 1: Subjects stay on same daily oral antipsychotic treatment as at baseline. Dose adjustments allowable as clinically indicated. arm 2: Subjects switch to daily oral ziprasidone from current antipsychotic(s). Dose titrated to clinically effective level.

Interventions: intervention 1: ziprasidone
Intervention descriptions: intervention 1: Patients assigned to ziprasidone arm are cross-titrated from current antipsychotic

Protocol document: