Conditions: Colitis, Ulcerative
Keywords: CD11b Ulcerative colitis 99mTc-HMPAO-labelled leukocyte scintigraphy
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 3
Healthy volunteers: no

Brief summary:
This study will involve the use of a new compound, SB-656933. Accumulation of inflammatory white blood cells (mostly polymorphonuclear neutrophils)in the gut (colon) may be contributing to the pathology of ulcerative colitis. It has been shown that SB-656933 reduces polymorphonuclear neutrophils (PMN) accumulation in pre-clinical models of colitis. 99m-Tc-HMPAO scintigraphy is a imaging technique which will be used in this study to observe the effect of SB656933 on the migration of PMN to inflamed tissue.

Detailed description:

Arms:
arm 1: None

Interventions: intervention 1: SB-656933
Intervention descriptions: intervention 1: 7 days repeat dose

Protocol document: