Conditions: Alzheimer's Disease
Keywords: Functional magnetic resonance imaging examination Alzheimer's Disease Donepezil hydrochloride Aricept
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 14
Healthy volunteers: no

Brief summary:
The objective of this study was to identify neural correlates of cognitive improvement after 3 months of donepezil hydrochloride treatment using either or both of two functional magnetic resonance imaging (fMRI) measures - the functional Hippocampus Connectivity Index (HCI) and Cerebral Blood Flow (CBF) Perfusion; in the Medial Temporal Lobe (MTL) network in subjects in the early stage of Alzheimer's Disease (AD).

Detailed description:

Arms:
arm 1: None

Interventions: intervention 1: Donepezil hydrochloride
Intervention descriptions: intervention 1: Donepezil hydrochloride 5 mg per day orally, once daily for 4 weeks, followed by 10 mg per day (two 5-mg tablets) for 8 weeks

Protocol document: