Conditions: Chronic Kidney Disease
Keywords: Chronic Kidney Disease Sitaxsentan
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 27
Healthy volunteers: no

Brief summary:
This study is being conducted to evaluate sitaxsentan dosing in subjects with chronic kidney disease.

Detailed description:

Arms:
arm 1: Sitaxsentan sodium 100 mg orally administered once daily (double blind arm) arm 2: Nifedipine 30 mg extended release tablets, orally administered once daily (open label arm) arm 3: Placebo for sitaxsentan, orally administered once daily (double blind arm)

Interventions: intervention 1: Open intervention 2: Nifedipine intervention 3: Placebo
Intervention descriptions: intervention 1: Sitaxsentan sodium 100 mg orally administered once daily (double blind arm) intervention 2: Nifedipine = 30 mg extended release tablets, orally administered once daily (open label arm) intervention 3: Placebo for sitaxsentan, orally administered once daily (double blind arm)

Protocol document: