Conditions: Infections, Fungal
Keywords: Pharmacokinetics Voriconazole Magnetic Resonance Spectroscopy
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 12
Healthy volunteers: yes

Brief summary:
To determine the amount of voriconazole in the brain after 2 loading doses and 3 maintenance doses over 3 days and compare it to the amount of voriconazole in the plasma.

Detailed description:

Arms:
arm 1: voriconazole twice daily

Interventions: intervention 1: voriconazole
Intervention descriptions: intervention 1: Multiple oral doses of voriconazole at 400 mg loading twice daily followed by 200 mg maintenance twice daily

Protocol document: