Conditions: Diabetes Mellitus, Type 2
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 342
Healthy volunteers: no

Brief summary:
A study to compare MK0893 to metformin or placebo for patients with Type 2 diabetes (Diabetes Mellitus).

Detailed description:

Arms:
arm 1: MK0893 tablets totaling 80 mg once daily. arm 2: MK0893 tablets totaling 60 mg once daily. arm 3: MK0893 40 mg tablet once daily. arm 4: MK0893 20 mg tablet once daily. arm 5: Metformin HCL 500 mg tablet twice daily BID titrating up to 1000 mg twice daily over 3 weeks. arm 6: PLA tablets. 12 week treatment period.

Interventions: intervention 1: MK0893 intervention 2: Metformin intervention 3: Placebo to MK0893 intervention 4: Placebo to Metformin
Intervention descriptions: intervention 1: MK0893 taken orally once daily; 20 mg and 40 mg tablets used in combination according to dose. intervention 2: Metformin HCL 500 mg tablet twice daily titrating up to 1000 mg twice daily over 3 weeks. intervention 3: Dose-matched placebo tablets to MK0893; taken orally once daily. intervention 4: Dose-matched placebo tablets to metformin (500 mg); taken orally twice daily.

Protocol document: