Conditions: Obesity
Keywords: Obesity Weight loss lorcaserin APD356 BLOOM Hypertension Dyslipidemia Sleep apnea glucose tolerance cardiovascular disease Arena
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 3182
Healthy volunteers: no

Brief summary:
The purpose of this study is to assess the weight loss effect of lorcaserin at the end of the first year of treatment (Week 52) and to assess the ability of lorcaserin to maintain weight loss at the end of the second year of treatment (Week 104)

Detailed description:

Arms:
arm 1: Lorcaserin 10 mg tablet each morning and evening arm 2: Matching placebo tablet each morning and evening

Interventions: intervention 1: Lorcaserin 10 mg BID intervention 2: Matching Placebo BID
Intervention descriptions: intervention 1: Lorcaserin 10 mg tablet each morning and evening for a duration of 52 or 104 weeks. intervention 2: Matching placebo tablet each morning and evening for a duration of 52 or 104 weeks.

Protocol document: