Conditions: AIDS
Keywords: Chloroquine Human Immunodeficiency Virus
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 28
Healthy volunteers: yes

Brief summary:
The purpose of this study is to evaluate the safety and reactogenicity of one booster dose of a HIV candidate vaccine after administration of one oral dose of chloroquine.

Detailed description:
The Protocol Posting has been updated following Protocol amendment 1, October 2009.

Arms:
arm 1: Subjects received a single dose of Nivaquine® tablets orally, 2 days prior to receiving a booster dose of the GSK732461 vaccine. arm 2: Subjects received a booster dose of the GSK732461 vaccine intramuscularly, in the deltoid region of the non-dominant arm.

Interventions: intervention 1: GSK Biologicals' HIV vaccine (732461) intervention 2: Chloroquine
Intervention descriptions: intervention 1: 1 dose intramuscular injection intervention 2: One dose of 300 mg

Protocol document: