Conditions: Type 2 Diabetes Mellitus
Allocation: NON_RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 18
Healthy volunteers: yes

Brief summary:
Studies of myocardial fuel selection using a novel palmitate-based PET probe

Detailed description:
A novel Positron Emission Tomography (PET) probe, 16- 18-F-fluoro-4-thiapalmitate, will be used to evaluate myocardial atty acid uptake. Studies will be done in humans with type 2 diabetes mellitus, and in controls. Studies will take place on 2 separate days, under fasting conditions and under insulin clamp conditions.

Arms:
arm 1: Studies will be performed on one day under fasting conditions, using a saline infusion. All subjects will receive infusions of radiolabeled acetate and radiolabeled thiapalmitate tracer (16-18-F-fluoro-4-thiapalmitate). arm 2: Studies will be performed on a separate day under fasting conditions, using an insulin infusion to achieve steady state insulin/glucose clamp conditions. Studies will be performed on one day under fasting conditions, using a saline infusion. All subjects will receive infusions of radiolabeled acetate and radiolabeled thiapalmitate tracer (16-18-F-fluoro-4-thiapalmitate).

Interventions: intervention 1: thiapalmitate tracer intervention 2: Saline intervention 3: Insulin
Intervention descriptions: intervention 1: Radiolabeled tracer infusion; occurs in all treatment arms intervention 2: Saline infusion for control intervention 3: Insulin infusion for insulin/glucose clamp procedure

Protocol document: