Conditions: Dental Crowding
Keywords: Third Molar Pain
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 20
Healthy volunteers: no

Brief summary:
Third molar surgery is complicated by pain and swelling for several days after surgery. Non-steroidal antiinflammatory drugs have been useful in combination with opioids for treatment. Nicotine has antiinflammatory and pain relieving properties. We will use nicotine or placebo as a nasal spray before surgery to determine whether nicotine affects pain or inflammation.

Detailed description:
This is a randomized double blind cross-over study. In each of two sittings, the third molars on one side of the mouth are removed. In one sitting the subject will receive a nicotine nasal spray (3mg) and in the other placebo. VAS and narcotic utilization will be compared within patients.

Arms:
arm 1: In one sitting the subject will receive a nicotine nasal spray, 3 mg, one application. arm 2: In one sitting the subject will receive a placebo nasal spray (0 mg), one application.

Interventions: intervention 1: Nicotine intervention 2: Placebo
Intervention descriptions: intervention 1: Nicotine nasal spray 3mg x 1 before surgery intervention 2: Placebo nasal spray 0mg x 1 before surgery

Protocol document: