Conditions: Invasive Candidiasis
Keywords: Candida Prophylaxis High risk adults Intensive care unit (ICU)
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 222
Healthy volunteers: no

Brief summary:
Adults admitted to intensive care units are at risk for a variety of complications. Infections due to the fungus called candida are of particular concern. The study will test the possibility that caspofungin, a new therapy for fungal infections, can successfully reduce the rate of candida infections in subjects at risk. It will also test if caspofungin is useful in treating subjects for this disease when diagnosed using a new blood test that is performed twice weekly, permitting earlier diagnosis than current practice standards.

Detailed description:

Arms:
arm 1: Caspofungin 50 mg Intravenous (IV) daily up to 28 days of therapy arm 2: Normal Saline 100 cc IV daily

Interventions: intervention 1: Caspofungin intervention 2: Normal Saline
Intervention descriptions: intervention 1: 50 mg IV daily intervention 2: 100 cc IV daily

Protocol document: