Conditions: Obesity
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 6
Healthy volunteers: yes

Brief summary:
The purpose of this study is to test a method of imaging (taking a picture) of the abdomen (belly), neck, thigh and calf (lower leg) areas of the body, using ultrasound along with a drug which makes the pictures look clearer. Ultrasound is a type of imaging that uses sound waves to create a picture of the inside of the human body. Two sets of pictures will be taken on two different days to see if the results are the same each time.

DEFINITY® is a drug given intravenously (through the vein). DEFINITY® is approved by the FDA to be used as an ultrasound contrast agent (makes the pictures look clearer) while taking pictures of the heart. In this study, DEFINITY® will be used while taking pictures of blood vessels in your abdomen (belly), neck, thigh and calf (lower leg). Since this use of DEFINITY® is different than the use approved by the FDA, this study will be performed under an FDA Investigational New Drug (IND) application.

Detailed description:

Arms:
arm 1: "Lean" defined as (BMI ≥18 and ≤25) arm 2: Obese grade I-II defined as (BMI\>30 and ≤35)

Interventions: intervention 1: Perflutren Lipid Microsphere Injectable Suspension
Intervention descriptions: intervention 1: 1.3 mL activated DEFINITY® diluted in 50 mL of preservative-free saline will be used

Protocol document: