Conditions: Glaucoma Application Site Pigmentation Changes
Keywords: periocular skin pigmentation Lumigan Travatan Xalatan latanoprost bimatoprost travoprost
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 89
Healthy volunteers: no

Brief summary:
The purpose of this study is to study changes in skin color that may be caused by using one of the three eye medicines: Xalatan, Travatan or Lumigan.

Detailed description:
One uncommon side effect of prostaglandin eye drops is a change in color of the skin around the eyes, which is reversible. There are three different brands of the medicine which are equally effective in lowering eye pressure but their likelihood of changing skin color is unknown. Qualifying patients will be randomly assigned to use one of the three eye drops. We will take skin color measurements from several locations on the face over one year to measure pigmentation changes.

Arms:
arm 1: Patients assigned to Lumigan/bimatoprost one drop before bedtime (qhs) to affected eye(s) arm 2: Patients assigned to Xalatan/latanoprost one drop before bedtime (qhs) to affected eye(s) arm 3: Patients assigned to Travatan/travoprost one drop before bedtime (qhs) to affected eye(s)

Interventions: intervention 1: latanoprost intervention 2: bimatoprost intervention 3: travoprost
Intervention descriptions: intervention 1: Xalatan/latanoprost 0.005% ophthalmic solution one drop qhs for one year intervention 2: Lumigan/bimatoprost 0.03% ophthalmic solution one drop qhs for one year intervention 3: Travatan/travoprost 0.004% ophthalmic solution one drop qhs for one year

Protocol document: