Conditions: Moderate to Severe Psoriasis
Keywords: Etanercept Acitretin Psoriasis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 60
Healthy volunteers: no

Brief summary:
To compare the efficacy of ETN 50mg twice weekly for 12 weeks followed by reduction to a maintenance dose of 25mg twice weekly at week 24 with that of combination of ETN 25 mg Twice Weekly plus Acitretin 10mg BID at week 24 in subjects with moderate to severe psoriasis.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None

Interventions: intervention 1: Etanercept intervention 2: Etanercept + Acitretin intervention 3: Acitretin
Intervention descriptions: intervention 1: Etanercept at a dose of 50mg twice weekly for 12 weeks followed by 25mg twice weekly for 12 weeks intervention 2: Combination of etanercept at a dose of 25mg twice weekly and acitretin 10mg BID for 24 weeks intervention 3: Acitretin at a dose of 10mg BID for 24 weeks

Protocol document: