Conditions: Constipation
Keywords: Opioid-Induced Constipation
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 460
Healthy volunteers: no

Brief summary:
The primary purpose of the protocol is to evaluate the safety, efficacy, and tolerability of subcutaneous MOA-728 versus placebo in subjects with chronic non-malignant pain who have Opioid-Induced Constipation (OIC).

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None

Interventions: intervention 1: N-methylnaltrexone bromide (MOA-728) intervention 2: placebo
Intervention descriptions: intervention 1: Subcutaneous intervention 2: placebo

Protocol document: