Conditions: Gastroesophageal Reflux Disease
Keywords: GERD Esophageal Reflux Gastro-Esophageal Reflux Regurgitation Gastric
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 276
Healthy volunteers: no

Brief summary:
The purpose of this research study is to compare the safety and effectiveness (how well the medicine works) of esomeprazole (study drug) to placebo (a capsule that does not contain any medication) taken daily in relieving nighttime heartburn and problems sleeping in patients with gastroesophageal reflux disease (GERD).

Detailed description:

Arms:
arm 1: Nexium 20 mg administered once daily as 22.3 mg of esomeprazole magnesium hydrate arm 2: None

Interventions: intervention 1: Esomeprazole intervention 2: Placebo
Intervention descriptions: intervention 1: Nexium 20 mg administered once daily as 22.3 mg of esomeprazole magnesium hydrate intervention 2: once daily

Protocol document: