Conditions: Acquired Antithrombin III Deficiency Coronary Artery Bypass
Keywords: antithrombin ATIII acquired deficiency anticoagulants cardiopulmonary bypass surgery complications postoperative outcomes
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 200
Healthy volunteers: no

Brief summary:
The purpose of this trial is to study the effects of preoperative antithrombin supplementation in patients undergoing cardiac surgery with cardiopulmonary bypass in order to maintain antithrombin levels in a range greater than 58% of functional activity and, eventually, to decrease negative clinical outcomes during the ICU stay.

Detailed description:

Arms:
arm 1: Preoperative ATIII supplementation administered immediately after anesthesia induction arm 2: No preoperative ATIII supplementation administered

Interventions: intervention 1: Antithrombin III
Intervention descriptions: intervention 1: Single dose of antithrombin III sufficient to achieve a preoperative level of 120%

Protocol document: