Conditions: Seizures
Keywords: seizures neonate levetiracetam Epilepsy central nervous system diseases anticonvulsants
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 7
Healthy volunteers: no

Brief summary:
The primary objective of this study is to determine the pharmacokinetic profile of a 50 mg/kg loading dose of intravenous levetiracetam (LEV) in term and late preterm infants with seizures. Secondary objectives are to evaluate the safety and efficacy of a 50 mg/kg loading dose of levetiracetam in term and preterm infants with seizures, and to obtain data on steady state drug levels of levetiracetam in neonates.

Detailed description:

Arms:

Interventions: intervention 1: levetiracetam
Intervention descriptions: intervention 1: 50 mg/kg single loading dose of IV levetiracetam

Protocol document: