Conditions: Major Depressive Disorder
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 490
Healthy volunteers: no

Brief summary:
To compare the efficacy of escitalopram fixed dose 20 mg/day in combination with fixed doses of gaboxadol (5 and 10 mg/day) versus escitalopram fixed dose 20 mg/day after 8 weeks of treatment in patients with Major Depressive Disorder

Detailed description:
Subjects participating in this study will be respectively randomised (1:2:2:2) to receive either:

* placebo or
* escitalopram 20 mg/day or
* escitalopram 20 mg/day in combination with gaboxadol 5 mg/day or
* escitalopram 20 mg/day in combination with gaboxadol 10 mg/day

Arms:
arm 1: None arm 2: None arm 3: None arm 4: None

Interventions: intervention 1: Escitalopram placebo intervention 2: Gaboxadol placebo intervention 3: Escitalopram 20 mg intervention 4: Gaboxadol 5 mg intervention 5: Gaboxadol 10 mg
Intervention descriptions: intervention 1: Once daily before bedtime for 8 weeks intervention 2: Once daily before bedtime for 8 weeks intervention 3: Once daily before bedtime for 8 weeks intervention 4: Once daily before bedtime for 8 weeks intervention 5: Once daily before bedtime for 8 weeks

Protocol document: