Conditions: Deep Vein Thrombosis Pulmonary Embolism
Keywords: Prevention of deep vein thrombosis and pulmonary embolism after total knee replacement surgery
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 3608
Healthy volunteers: no

Brief summary:
The purpose of this study is to learn if apixaban can prevent blood clots in the leg (deep vein Thrombosis \[DVT\]) and lung (pulmonary embolism \[PE\]) that sometimes occur after knee replacement surgery and to learn how apixaban compares to enoxaparin (Lovenox®) for preventing these clots. The safety of apixaban will also be studied.

Detailed description:

Arms:
arm 1: \+ placebo arm 2: \+ placebo

Interventions: intervention 1: Enoxaparin + Placebo intervention 2: Apixaban + Placebo
Intervention descriptions: intervention 1: Syringes + tablets, Subcutaneous + Oral, 30mg, twice daily, 12 day treatment period intervention 2: Tablet + Syringes, Oral + subcutaneous, 2.5 mg, twice daily, 12 day treatment period

Protocol document: