Conditions: Neuropathic Pain
Keywords: Methodology Quantitative Sensory Testing Neuropathies Pain Pregabalin
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 31
Healthy volunteers: no

Brief summary:
Conventional pain efficacy measures such as Visual Analogue Scores (VAS) are often unable to detect treatment efficacy in small-scale clinical trials. Combining conventional pain efficacy measures with quantitative sensory testing (QST) may provide more sensitive and informative outcome measures in clinical trials.

Detailed description:
Methodology to assess reproducibility and sensitivity of quantitative sensory testing

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Pregabalin intervention 2: Placebo
Intervention descriptions: intervention 1: Dose titration according to following regimen: 75mg BID for 3 days; 150mg for 4 days; 225mg BID for 4 days; 300mg BID for 17 days. Dose reduced for renally impaired patients intervention 2: BID dosing for 28 days

Protocol document: