Conditions: Allergic Conjunctivitis
Keywords: Allergic conjunctivitis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 13
Healthy volunteers: no

Brief summary:
The purpose of this study was to evaluate ocular responses with different allergen provocation methods.

Detailed description:
Subjects demonstrating a successful allergen response to a common allergen received the first study treatment and used as instructed for 5 days, after which they entered the Environmental Exposure Chamber (EEC) for a 3-hour exposure to a known concentration of the allergen. After waiting at least 7 days, subjects received the second study treatment and used as instructed for 5 days, after which a 3-hour Conjunctival Allergen Provocation Test (CAPT) was performed with an escalating concentration of the allergen. Subjects dosed with study treatment approximately 15 minutes prior to each allergen provocation test.

Arms:
arm 1: One drop twice daily in each eye for five days prior to allergen provocation testing, followed by an additional drop in each eye approximately 15 minutes prior to start of testing. arm 2: One drop twice daily in each eye for five days prior to allergen provocation testing, followed by an additional drop in each eye approximately 15 minutes prior to start of testing.

Interventions: intervention 1: Olopatadine hydrochloride, 0.1% ophthalmic solution (Patanol) intervention 2: Dextran 70 0.1%, hydroxypropyl methylcellulose 0.3% (Tears Naturale II)
Intervention descriptions: intervention 1: One drop twice daily in each eye for 5 days, followed by an additional drop in each eye prior to allergen test. intervention 2: One drop twice daily in each eye for 5 days, followed by an additional drop in each eye prior to allergen test.

Protocol document: