Conditions: Chronic Hepatitis B
Keywords: treatment naive CHB adefovir monotherapy
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 105
Healthy volunteers: no

Brief summary:
This study is designed to compare the efficacy and safety of adefovir dipivoxil 10 mg with lamivudine 100 mg in Japanese patients with compensated chronic hepatitis B over 52-week periods.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: LAM group intervention 2: ADV group
Intervention descriptions: intervention 1: Subjects took one LAM 100mg tablet orally once daily and one ADV placebo tablet orally once daily. intervention 2: Subjects took one ADV 10mg tablet orally once daily and one LAM placebo tablet orally once daily.

Protocol document: