Conditions: Dental Caries
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 65
Healthy volunteers: yes

Brief summary:
This study will evaluate and compare the effect of the amount of toothpaste used and brushing time on enamel strengthening (percent of surface microhardness recovery, % SMHR) and enamel fluoride uptake (EFU).

Detailed description:

Arms:
arm 1: Participants brush twice a daily for 45 seconds with experimental dentifrice. arm 2: Participants brush twice a daily for 45 seconds with experimental dentifrice. arm 3: Participants brush twice a daily for 2 minutes with experimental dentifrice. arm 4: Participants brush twice a daily for 2 minutes with experimental dentifrice. arm 5: Participants brush twice a daily for 2 minutes with controll dentifrice.

Interventions: intervention 1: Sodium fluoride / silica and carbopol, 0.5g intervention 2: Sodium fluoride / silica and carbopol, 1.5g intervention 3: Sodium fluoride / silica and carbopol, 1.5g intervention 4: Fluoride free dentifrice
Intervention descriptions: intervention 1: Dentifrice containing 1150 parts per million (ppm) fluoride as sodium fluoride / silica and 0.4% carbopol intervention 2: Dentifrice containing 1150 ppm fluoride as sodium fluoride / silica and 0.4% carbopol intervention 3: Dentifrice containing 250 ppm fluoride as sodium fluoride / silica and 0.4% carbopol intervention 4: A non fluoride dentifrice was given to participants of each arm at washout period

Protocol document: