Conditions: Depressive Disorder
Keywords: MDD flexible-dose Major Depressive Disorder paroxetine GSK372475
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 492
Healthy volunteers: no

Brief summary:
To evaluate the efficacy, safety and tolerability of GSK372475 compared with placebo in the treatment of outpatients subjects with major depressive disorder to exhibit decreased pleasure, interest and energy.

Detailed description:

Arms:
arm 1: GSK372475 1.0- 1.5 mg/day arm 2: Paroxetine 20-30 mg/day arm 3: Placebo to Match

Interventions: intervention 1: GSK372475 intervention 2: Paroxetine intervention 3: Placebo
Intervention descriptions: intervention 1: GSK372475 1.0-1.5 mg/day intervention 2: Paroxetine 20-30 mg/day intervention 3: Placebo to Match

Protocol document: