Conditions: Healthy Volunteers
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 75
Healthy volunteers: yes

Brief summary:
The purpose of this study is to assess the bioavailability of Apixaban solution administered through NGT and washed with Dextrose 5% in water (D5W) or infant formula relative to Apixaban solution administered orally in healthy subjects

Detailed description:

Arms:
arm 1: Single dose Apixaban 5 mg (0.4 mg/mL x 12.5 mL) oral solution via oral syringe arm 2: Single dose Apixaban 5 mg (0.4 mg/mL x 12.5 mL) oral solution via nasogastric tube (NGT) immediately followed by 60 mL of D5W via NGT arm 3: Single dose Apixaban 5 mg (0.4 mg/mL x 12.5 mL) oral solution via NGT immediately followed by 60 mL of infant formula via NGT

Interventions: intervention 1: Apixaban
Intervention descriptions: intervention 1: None

Protocol document: