Conditions: Hypertension Metabolic Disorder
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 1738
Healthy volunteers: no

Brief summary:
To determine if a one year treatment Losartan with or without HCTZ at different dosages have an effect on metabolic parameters in patients with hypertension and the metabolic syndrome.

Detailed description:

Arms:
arm 1: Losartan (MK0954) / Losartan + HCTZ (MK0954A)

Interventions: intervention 1: losartan potassium (+) hydrochlorothiazide
Intervention descriptions: intervention 1: All patients received Losartan 50mg at Visit 2 titrated to Losartan 100mg (if target BP not achieved) titrated to Losartan 100mg + HCTZ 12.5mg (if necessary) up to Losartan 100mg + HCTZ 25mg. Duration of treatment was one year.

Protocol document: