Conditions: Coronary Artery Disease (CAD)
Keywords: pharmacologic stress ischemia coronary artery disease (CAD)
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 347
Healthy volunteers: no

Brief summary:
Observe whether the administration of caffeine prior to regadenoson will affect the interpretation of test results in subjects with coronary artery disease (CAD) undergoing SPECT MPI

Detailed description:
All subjects will undergo rest and stress scans. Those subjects who qualify by demonstrating at least 1 reversible defect, will undergo a third scan. All stress scans will involve the injection of regadenoson as the pharmacologic stress agent. Prior to the third scan, the subject will be administered blinded capsules of placebo or caffeine.

Arms:
arm 1: Two placebo capsules plus 0.4 mg regadenoson per 5mL intravenous (IV) bolus injection arm 2: One 200 mg Caffeine capsule and one placebo capsule plus 0.4 mg regadenoson per 5mL intravenous bolus injection arm 3: Two 200 mg Caffeine capsules plus 0.4 mg regadenoson per 5mL intravenous bolus injection

Interventions: intervention 1: regadenoson intervention 2: overencapsulated caffeine intervention 3: technetium intervention 4: placebo
Intervention descriptions: intervention 1: IV intervention 2: oral intervention 3: IV intervention 4: oral

Protocol document: