Conditions: Lung Cancer
Keywords: Healthy Prevention
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 40
Healthy volunteers: no

Brief summary:
To compare the difference of a marker of cellular proliferation in all bronchial biopsy specimens of former smokers stratified by lung cancer risk, collected before and after treatment per patient between the enzastaurin and placebo groups.

Detailed description:

Arms:
arm 1: Treatment with enzastaurin 500 milligrams (mg) orally (po) once daily (QD) given as 4 tablets (125 mg each). arm 2: Treatment with placebo po QD appearing identical to enzastaurin.

Interventions: intervention 1: Enzastaurin intervention 2: Placebo
Intervention descriptions: intervention 1: 500 mg po QD for 6 months intervention 2: po QD for 6 months

Protocol document: