Conditions: Substance Abuse
Keywords: cocaine dependence stimulants
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 50
Healthy volunteers: yes

Brief summary:
This placebo-controlled, double-blind, randomized pilot clinical trial will evaluate atomoxetine (Strattera®) for the treatment of cocaine dependence. Cocaine-dependent individuals, who are healthy and are seeking treatment for their substance abuse, will be randomized to receive either atomoxetine (n=25) or a matched-placebo (n=25) during a trial lasting 12 weeks; there will be a double-blind, ascending dose lead-in order to achieve maintenance on the assigned active dose safely. Contingency management procedures will be used to reinforce attendance and compliance with study procedures. Primary outcome measures will include urinalysis data assessing cocaine use.

Detailed description:

Arms:
arm 1: Atomoxetine arm 2: Matched Placebo

Interventions: intervention 1: atomoxetine intervention 2: placebo
Intervention descriptions: intervention 1: Once daily oral dosing intervention 2: Once daily oral dosing - matched placebo

Protocol document: