Conditions: Diabetes Mellitus, Type 2
Allocation: RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 48
Healthy volunteers: no

Brief summary:
To investigate safety, tolerability, pharmacokinetics and pharmacodynamics of BI 10773 with repeat dosing for eight days and the exploration of the pharmacokinetics and pharmacodynamics of BI 10773 after multiple dosing, including dose proportionality and assessment of steady state.

Detailed description:

Arms:
arm 1: multiple doses as tablet arm 2: multiple doses as tablet arm 3: multiple doses as tablet arm 4: multiple doses as tablet

Interventions: intervention 1: BI 10773 Placebo intervention 2: BI 10773 intervention 3: BI 10773 Placebo intervention 4: BI 10773 intervention 5: BI 10773 Placebo intervention 6: BI 10773 Placebo intervention 7: BI 10773 intervention 8: BI 10773
Intervention descriptions: intervention 1: po taken fasting with 240 mL water intervention 2: po taken fasting with 240 mL water intervention 3: po taken fasting with 240 mL water intervention 4: po taken fasting with 240 mL water intervention 5: po taken fasting with 240 mL water intervention 6: po taken fasting with 240 mL water intervention 7: po taken fasting with 240 mL water intervention 8: po taken fasting with 240 mL water

Protocol document: