Conditions: Hypertension
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 64
Healthy volunteers: no

Brief summary:
This study will measure and compare changes in insulin production and sensitivity using the hyperglycemic clamp technique in obese patients with impaired glucose tolerance and hypertension treated with placebo, isosorbide mononitrate (ISMN) or hydrochlorothiazide (HCTZ).

Detailed description:

Arms:
arm 1: Placebo in Period 1 followed by HCTZ in Period 2 arm 2: HCTZ in Period 1, followed by placebo in Period 2 arm 3: Placebo in Period 1, followed by ISMN in Period 2 arm 4: ISMN in Period 1, followed by placebo in Period 2

Interventions: intervention 1: Hydrochlorothiazide (HCTZ) intervention 2: Comparator: Placebo to HCTZ intervention 3: Isosorbide mononitrate (ISMN) intervention 4: Comparator: Placebo to ISMN
Intervention descriptions: intervention 1: HCTZ 50 mg (two 25 mg capsules) once daily for 4 weeks per treatment period. intervention 2: Placebo to HCTZ two 0 mg capsules once daily for 4 weeks per treatment period intervention 3: ISMN 60 mg extended release capsule once daily for 4 weeks per treatment period intervention 4: Placebo to ISMN 0 mg capsule once daily for 4 weeks per treatment period

Protocol document: