Conditions: Cataract Extraction
Keywords: Bioavailability
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 105
Healthy volunteers: no

Brief summary:
This study is being conducted to assess the concentration of besifloxacin, moxifloxacin, or gatifloxacin in aqueous humor samples collected following topical instillation of the associated formulation in subjects undergoing cataract surgery.

Detailed description:

Arms:
arm 1: Besifloxacin ophthalmic suspension arm 2: Vigamox (moxifloxacin ophthalmic solution, 0.5%) arm 3: Zymar (gatifloxacin ophthalmic solution, 0.3%)

Interventions: intervention 1: Besifloxacin hydrochloride intervention 2: moxifloxacin hydrochloride intervention 3: gatifloxacin
Intervention descriptions: intervention 1: Instill besifloxacin study medication in the study eye prior to making an incision for cataract extraction surgery. intervention 2: Instill moxifloxacin study medication in the study eye prior to making an incision for cataract extraction surgery. intervention 3: Instill gatifloxacin study medication in the study eye prior to making an incision for cataract extraction surgery.

Protocol document: