Conditions: Methamphetamine Dependence
Keywords: Methamphetamine Dependence
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 210
Healthy volunteers: yes

Brief summary:
The purpose of this study will be to examine the safety and efficacy of modafinil in increasing number of methamphetamine non-use weeks in subjects with methamphetamine dependence.

Detailed description:
To evaluate the efficacy and safety of modafinil in reducing methamphetamine use in subjects with methamphetamine dependence. It is hypothesized that modafinil, compared to placebo, will be associated with an increase in the number of methamphetamine non-use weeks over time as measured by quantitative urine analysis for methamphetamine.

Arms:
arm 1: Participants will receive a Modafinil 200 mg or 400 mg tablet one time per day for 12 weeks arm 2: Participants will receive a matching Modafinil placebo 200 mg or 400 mg tablet one time per day for 12 weeks

Interventions: intervention 1: Modafinil intervention 2: Placebo
Intervention descriptions: intervention 1: 200 mg or 400 mg /daily intervention 2: Placebo / daily

Protocol document: