Conditions: Pain
Keywords: acute pain nicotine nausea sedation
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 68
Healthy volunteers: no

Brief summary:
Effect of nicotine patch as an adjutant for acute pain after surgery.

Detailed description:
This is a dose finding trial for nicotine patches as analgesics. Doses used are 5mg/ 10mg/ 15mg or placebo. Primary outcome variable is reported pain score (VAS), secondary is morphine PCA utilization, nausea, sedation, and hemodynamic changes.

Arms:
arm 1: Smokers who were treated with nicotine arm 2: Nonsmokers who were treated with nicotine arm 3: Smokers who were treated with placebo arm 4: Nonsmokers who were treated with placebo

Interventions: intervention 1: nicotine patch intervention 2: nicotine patch intervention 3: placebo intervention 4: placebo
Intervention descriptions: intervention 1: nicotine patch (0,5,10 or 15mg/day) applied to smokers intervention 2: nicotine patch (0,5,10,or 15mg/day) applied to nonsmokers intervention 3: placebo patch applied to smokers intervention 4: placebo patch applied to nonsmokers

Protocol document: