Conditions: Any Cancer Breast Cancer
Keywords: Any cancer Breast cancer Lovastatin Docetaxel
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 9
Healthy volunteers: no

Brief summary:
This purpose of this study is to evaluate the use of two medications, docetaxel and lovastatin to determine the highest dose of lovastatin and docetaxel that can be given safely as well as the safety of combining the two drugs and the effect on the subject's tumor. Subjects can have any cancer.

Detailed description:
The primary objective of this study is to determine the maximum tolerated dose (MTD) of lovastatin and docetaxel in patients with various different cancers.

Arms:
arm 1: Determine the maximum tolerated dose (MTD) of escalating doses of lovastatin in combination with docetaxel in patients with any type of solid tumor.

Interventions: intervention 1: Lovastatin intervention 2: Docetaxel
Intervention descriptions: intervention 1: Given PO intervention 2: Given IV

Protocol document: