Conditions: Asthma, Exercise-Induced
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 47
Healthy volunteers: no

Brief summary:
To determine the effect of an approved medication being studied in support of a new approach in the prevention of exercise-induced asthma (a worsening of asthma caused by exercise, also known as exercise-induced bronchospasm), in patients who have a history of worsening asthma after exercise.

Detailed description:

Arms:
arm 1: Montelukast - Salmeterol - Placebo arm 2: Montelukast - Placebo - Salmeterol arm 3: Salmeterol - Montelukast - Placebo arm 4: Salmeterol - Placebo - Montelukast arm 5: Placebo - Montelukast - Salmeterol arm 6: Placebo - Salmeterol - Montelukast

Interventions: intervention 1: Comparator: Montelukast intervention 2: Comparator: Salmeterol intervention 3: Comparator: Placebo (montelukast) intervention 4: Comparator: Placebo (salmeterol)
Intervention descriptions: intervention 1: 1 dose montelukast 10 mg tablet given orally in one of three treatment periods intervention 2: 1 dose of 50 ug salmeterol given by inhalation in one of three treatment periods intervention 3: 1 dose matching-image placebo to montelukast tablet in two of three treatment periods intervention 4: 1 dose matching-image placebo of salmeterol 50 ug inhalation in two of three treatment periods

Protocol document: