Conditions: Neuromuscular Blockade
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 6
Healthy volunteers: no

Brief summary:
The clinical trial objectives were to evaluate the dialysability of the sugammadex-rocuronium complex; it's safety and efficacy in participants with severe renal impairment.

Detailed description:
The current trial was designed to evaluate the dialysability of the sugammadex-rocuronium complex in participants with severe renal impairment. A dose of 4.0 mg/kg sugammadex was administered 15 minutes after administration of 0.6 mg/kg rocuronium. Blood and dialysate samples were collected before, during and after hemodialysis/filtration, for calculation of clearance of sugammadex-rocuronium complex and assessment of rebound.

Arms:
arm 1: IV single bolus dose of 4.0 mg/kg sugammadex

Interventions: intervention 1: sugammadex intervention 2: Rocuronium
Intervention descriptions: intervention 1: At 15 minutes after administration of rocuronium, an IV single bolus dose of 4.0 mg/kg sugammadex was administered. intervention 2: After achieving stable anesthesia an IV single bolus dose of 0.6 mg/kg rocuronium was administered

Protocol document: