Conditions: Chronic Obstructive Pulmonary Disease
Keywords: Chronic Obstructive Pulmonary Lung Respiratory disease Efficacy Safety and tolerability Placebo-controlled Pharmacokinetics COPD
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 838
Healthy volunteers: no

Brief summary:
The primary objective is to evaluate the dose-response relationship and efficacy of AZD9668 at 3 dose levels compared with placebo in symptomatic COPD patients by assessing effects on lung function and symptoms of COPD.

Detailed description:

Arms:
arm 1: AZD9668 active treatment arm 2: AZD9668 active treatment arm 3: AZD9668 active treatment arm 4: AZD9668 placebo treatment

Interventions: intervention 1: AZD9668 intervention 2: AZD9668 intervention 3: AZD9668 intervention 4: AZD9668 Placebo
Intervention descriptions: intervention 1: 2 x 30 mg oral tablets twice daily (bid) for 12 weeks intervention 2: 2 x 10 mg oral tablets twice daily (bid) for 12 weeks intervention 3: 2 x 2.5 mg oral tablets twice daily (bid) for 12 weeks intervention 4: 2 x Matched placebo to oral tablet twice daily (bid) for 12 weeks

Protocol document: