Conditions: End Stage Renal Disease
Keywords: PHARMACOKINETIC NOS
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 18
Healthy volunteers: yes

Brief summary:
The purpose of this study is to assess the pharmacokinetics of a single oral dose of 5 mg Apixaban in subjects with normal renal function and subjects with end stage renal disease (ESRD) maintained with hemodialysis.

Detailed description:
Primary Purpose : To provide a clear understanding of the pharmacokinetics of Apixaban in subjects with ESRD and to determine the effect of hemodialysis on Apixaban pharmacokinetics .

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Apixaban intervention 2: Apixaban
Intervention descriptions: intervention 1: Tablets, Oral, 5 mg, Once, 4 days intervention 2: Tablets, Oral, 5 mg, Twice, 15 days

Protocol document: