Conditions: End-stage Renal Disease Renal Failure Chronic Requiring Hemodialysis
Keywords: End-stage renal disease hemodialysis chronic renal failure
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 16
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine whether daptomycin at a higher dose given during the last 30 minutes of a dialysis session is equal to a lower dose of daptomycin given after a dialysis session.

Detailed description:

Arms:
arm 1: 9 mg/kg of daptomycin administered during the last 30 minutes of a hemodialysis session. arm 2: Post dialysis dosing

Interventions: intervention 1: daptomycin intervention 2: daptomycin
Intervention descriptions: intervention 1: intradialytic: 9 mg/kg during the last 30 minutes of dialysis intervention 2: 6 mg/kg administered after a hemodialysis session

Protocol document: