Conditions: Arthritis, Rheumatoid
Keywords: DMARD therapy
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 509
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine the effectiveness and safety, over 6 months, of 6 dose regimens of CP-690,550, combined with methotrexate, for the treatment of adults with active rheumatoid arthritis.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None arm 4: None arm 5: None arm 6: None arm 7: Dummy tablets

Interventions: intervention 1: CP-690,550 intervention 2: CP-690,550 intervention 3: CP-690,550 intervention 4: CP-690,550 intervention 5: CP-690,550 intervention 6: CP-690,550 intervention 7: placebo
Intervention descriptions: intervention 1: 4 blinded tablets administered BID intervention 2: 4 blinded tablets administered BID intervention 3: 4 blinded tablets administered BID intervention 4: 4 blinded tablets administered BID intervention 5: 4 blinded tablets administered BID intervention 6: Oral tablets intervention 7: Placebo

Protocol document: