Conditions: Melanoma Advanced Melanoma
Keywords: Temzolomide Gleevec Melanoma Advanced melanoma Phase II
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 32
Healthy volunteers: no

Brief summary:
This study has been designed to evaluate the side effects of Gleevec when given in combination with Temzolomide; and to learn more about how these drugs work in the body and whether this combination is useful in treating patients with melanoma.

Detailed description:

Arms:
arm 1: Temozolomide plus imatinib

Interventions: intervention 1: Gleevec intervention 2: Temodar
Intervention descriptions: intervention 1: Gleevec (600 mg) daily. intervention 2: Temzolomide (1000 mg/m2) over 5 days on a 28 day cycle.

Protocol document: