Conditions: Myelodysplastic Syndrome Acute Myeloid Leukemia
Keywords: Therapy-related myelodysplastic syndrome/ Therapy -related Acute myeloid leukemia Myelodysplastic syndrome Acute myeloid leukemia
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 32
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine the effectiveness of a particular combination of drugs used to treat cancer.

Detailed description:

Arms:
arm 1: Ara-C Mitoxantrone Etoposide Stem cell mobilization Autologous transplant

Interventions: intervention 1: Ara-C intervention 2: Mitoxantrone intervention 3: Etoposide
Intervention descriptions: intervention 1: Induction: 3000mg/m2 IV infusion for day 1 and day 5

Mobilization: within 2 weeks of end of induction therapy - 2000mg/m2 as 2 hour IV infusion once every 12 hours for 3 days (6 doses total) intervention 2: Induction: 30mg/m2 after the end of HiDAC day 1 and day 5 intervention 3: Mobilization: 30mg/kg over 6 doses given once every 12 hours for 3 days

Protocol document: