Conditions: Cannabis Dependence Cannabis Withdrawal
Keywords: Cannabis Dependence Marijuana Dependence Cannabis Withdrawal Rimonabant cannabinoid receptor type 1 (CB1) inverse agonist Neuropsychology functional magnetic resonance imaging (fMRI) Endocannabinoids Cortisol
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 66
Healthy volunteers: yes

Brief summary:
The purpose of this study is to find out more about cognitive functioning in people who are cannabis dependent, relative to people who do not use cannabis, and how their brains process information after one month of not using cannabis. An additional goal is to characterize the severity of cannabis dependence using precipitated and naturalistic withdrawal with a double blind, placebo controlled, single administration of rimonabant. Research assessments occur bi-weekly throughout this 28 day study.

Detailed description:

Arms:
arm 1: Cannabis dependent young adults administered rimonabant 90 mg at Day 0 and followed for 28 days post. arm 2: Cannabis dependent young adults administered matched placebo at Day 0 and followed for 28 days post. arm 3: Non-cannabis using demographically similar young adults followed for 28 days.

Interventions: intervention 1: rimonabant intervention 2: placebo
Intervention descriptions: intervention 1: double blind, placebo controlled, single 90 mg dose intervention 2: matched placebo

Protocol document: