Conditions: Healthy
Keywords: TQT study CP-690 550
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 60
Healthy volunteers: yes

Brief summary:
ICH E14 recommends that a thorough QT/QTc (TQT) study should be performed to determine whether intensive monitoring of QT interval in target patient populations is required during later stages of development. The current study is designed to ascertain whether CP-690,550 is associated with QTc prolongation.

Detailed description:
The current study is designed to ascertain whether CP-690,550 is associated with QTc prolongation

Arms:
arm 1: None arm 2: None arm 3: None

Interventions: intervention 1: CP-690,550 intervention 2: Placebo intervention 3: Moxifloxacin
Intervention descriptions: intervention 1: Single dose 100 mg (5 x 20 mg tablets) intervention 2: Single dose placebo tablets (5 tablets) intervention 3: Single dose Avelox 400 mg tablet

Protocol document: