Conditions: Methamphetamine Dependence
Keywords: Methamphetamine Modafinil Addiction Craving Cognitive
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 40
Healthy volunteers: no

Brief summary:
Methamphetamine dependence is a serious public health problem with no pharmacologic treatments currently available. Relapse rates are high in this population. Exposure to cues previously associated with methamphetamine use may induce profound craving in abstinent individuals. Chronic methamphetamine abuse is associated with selective cognitive deficits that may undermine successful participation in psychosocial treatments. Medications which improve cognitive deficits in methamphetamine-dependent individuals may improve abstinence rates, especially in the critical early period of recovery. Modafinil is an atypical stimulant medication with evidence to support its use in treating cocaine dependence and attention deficit/hyperactivity disorder. The proposed studies are designed to evaluate modafinil as a potential treatment for methamphetamine dependence and its cognitive sequelae.

Detailed description:

Arms:
arm 1: Modafinil 400 mg daily arm 2: Placebo

Interventions: intervention 1: Modafinil intervention 2: Placebo
Intervention descriptions: intervention 1: 400 mg daily for four weeks intervention 2: Placebo 2 tablets daily for 4 weeks

Protocol document: