Conditions: Cataracts
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 126
Healthy volunteers: yes

Brief summary:
Approximately 126 subjects scheduled to undergo cataract surgery by phacoemulsification, will be randomized in an even allocation (1:1:1) to either Acuvail, Xibrom, or Nevanac. Subjects will be instructed to begin dosing the study medication in the operative eye the day before surgery and continue dosing on the day of surgery. Beginning one hour before surgery, 1 drop of study medication will be instilled by operating room staff approximately every 15 minutes for a total of 3 doses. At the designated time a paracentesis will be performed at the start of the cataract procedure and at least 0.15 cc of aqueous humor will be collected. The sample will be immediately stored on dry ice and shipped to a laboratory for analysis.

Detailed description:

Arms:
arm 1: Acuvail to be given preoperatively. One drop 2 times daily (BID), 1 day pre op and day of surgery 3 doses prior to surgery arm 2: Xibrom to be given 1 drop 2 times daily (BID) the day before surgery and 3 doses the day of surgery prior to surgery arm 3: One day before surgery 1 drop 2 times daily (BID), then 3 doses the day of surgery

Interventions: intervention 1: Ketorolac Tromethamine 0.45% intervention 2: bromfenac 0.09% intervention 3: nepafenac 0.1%
Intervention descriptions: intervention 1: One drop BID the day before surgery and then 3 doses the day of surgery prior to surgery intervention 2: One day pre operative 1 drop BID then 3 doses pre op day of surgery intervention 3: One drop BID, 1 day pre operative and then 3 doses the day of surgery

Protocol document: