Conditions: Seasonal Allergic Rhinitis
Keywords: Sublingual immunotherapy Rhinitis Conjunctivitis Allergen challenge Allergen exposition chamber Grass pollen tablet Allergic rhinoconjunctivitis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 89
Healthy volunteers: no

Brief summary:
The objective of this study is to assess the effect of grass pollen extract SLIT tablets on the Rhinoconjunctivitis Total Symptom Score (RTSS) of the six rhinoconjunctivitis symptoms in response to grass pollen challenge after one week, one, two and four months of treatment in patients suffering from Seasonal Allergic Rhinoconjunctivitis (SAR) due to grass pollen.

Detailed description:
The purpose of this study is to determine whether SLIT tablets are effective on symptoms of allergic rhinitis compared to placebo in patients suffering from allergic rhinitis to grass pollen when exposed in an allergen chamber and also to determine the onset of action of SLIT tablets on allergic rhinitis symptoms.

Arms:
arm 1: 300 IR grass pollen allergen extract tablet arm 2: Placebo tablet

Interventions: intervention 1: 300 IR grass pollen allergen extract tablet intervention 2: Placebo tablet
Intervention descriptions: intervention 1: 300 IR grass pollen allergen extract tablet once daily during four months intervention 2: Placebo tablet once daily during four months

Protocol document: