Conditions: Infections, Gram-Positive Bacterial Abscess Burns Cellulitis Ulcer Wound Infections
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 169
Healthy volunteers: no

Brief summary:
Serious infections caused by resistant bacteria are becoming more of a medical problem throughout the world. One of the ways to deal with this problem is to develop new drugs that can control these bacteria. This study will measure how well TD-6424 (Telavancin) can control infections and whether this drug can be safely given to patients.

Detailed description:

Arms:
arm 1: None arm 2: cSSSI - complicated skin and skin structure infections

Interventions: intervention 1: Telavancin intervention 2: Vancomycin or antistaphylococcal penicillin
Intervention descriptions: intervention 1: Telavancin 7.5 mg/kg/day IV (intravenously) for up to 14 days intervention 2: Vancomycin 1 Gram IV (intravenously) every 12 hrs or nafcillin 2 Grams, oxacillin 2 Grams, or (in South Africa) cloxacillin 0.5 - 1 Gram, IV (intravenously) every 6 hrs for up to 14 days.

Protocol document: