Conditions: Low Bone Mass Low Bone Mineral Density Osteoporosis Postmenopausal Osteoporosis
Keywords: Low Bone Mass Low Bone Mineral Density Osteoporosis Postmenopausal Osteoporosis Bone Biopsy Transiliac Crest Bone Histology Histomorphometry
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 15
Healthy volunteers: no

Brief summary:
To characterize the effects of discontinuation of denosumab therapy on variables of bone histology in postmenopausal women with low bone mass or osteoporosis. Patients who have received denosumab and completed study 20050179 (NCT00293813), completed study 20050141 (NCT00330460), completed study 20060237 (NCT00515463), completed study 20030216 (NCT00089791) but did not enroll in study 20060289 (NCT00523341) will be included in this study. Patients who will participate in the off-treatment imaging study for 20080747 (NCT00890981) are also eligible.

Detailed description:

Arms:
arm 1: Participants who had previously received denosumab received a transiliac crest bone biopsy performed following standard labeling procedures with tetracycline or tetracycline derivative.

Interventions: intervention 1: Previous denosumab
Intervention descriptions: intervention 1: Participants who had previously received denosumab received a transiliac crest bone biopsy performed following standard labeling procedures with tetracycline or tetracycline derivative.

Protocol document: