Conditions: Open-angle Glaucoma Ocular Hypertension
Keywords: Intraocular pressure Open-angle glaucoma Ocular hypertension Adherence Compliance
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 102
Healthy volunteers: no

Brief summary:
The purpose of the study is to compare adherence in patients on a fixed combination of travoprost 0.004%/timolol 0.5% and patients on a concomitant combination of travoprost 0.004% and timolol 0.5% using the Travalert® device.

Detailed description:

Arms:
arm 1: One drop in the study eye once daily at 9 p.m. for six months using the Travalert device. arm 2: One drop travoprost in the study eye at 9 p.m. and one drop of timolol in the study eye twice daily (9 a.m. and 9 p.m.) for six months using a separate Travalert device for each medication.

Interventions: intervention 1: Travoprost 0.004%/timolol 0.5% fixed combination eye drops (DuoTrav) intervention 2: Travoprost 0.004% eye drops intervention 3: Timolol 0.05% eye drops intervention 4: Travalert Dosing Aid
Intervention descriptions: intervention 1: One drop in the study eye once daily at 9 p.m. for six months using the Travalert device. intervention 2: One drop in the study eye once daily at 9 p.m. for six months using the Travalert device. intervention 3: One drop in the study eye twice daily at 9 a.m. and 9 p.m. for six months using the Travalert device. intervention 4: Approved device used with study medication to record time of instillation and quantify dosing

Protocol document: