Conditions: Type 2 Diabetes Mellitus
Keywords: thiazolidinedione sulfonylurea endothelial function
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 36
Healthy volunteers: no

Brief summary:
The purpose of this study is to compare the vascular effects of two commonly used diabetes medications, rosiglitazone and glyburide in type 2 diabetic patients.

Detailed description:
Rosiglitazone and glyburide are two commonly used diabetic medications that have both been shown to be effective in controlling blood glucose levels. Since they work in different ways, they may have different effects on the health of the blood vessels. This study will assess which medication is better at improving the health of the arteries separate from the blood glucose lowering effects. Artery health will be assessed non-invasively by ultrasound. Certain markers of atherosclerosis found in the blood will also be measured.

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: rosiglitazone intervention 2: glyburide
Intervention descriptions: intervention 1: None intervention 2: None

Protocol document: