Conditions: Hypertension
Keywords: Hypertension, aliskiren, ramipril, colonoscopy
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 774
Healthy volunteers: no

Brief summary:
This study will evaluate the long-term gastrointestinal (GI) safety and efficacy of aliskiren (300 mg) compared to ramipril (10mg) in patients ≥ 50 years with essential hypertension.

Detailed description:

Arms:
arm 1: For the first 2 weeks of the study, participants received aliskiren 150 mg once a day and were then forced titrated to aliskiren 300 mg once a day for 52 weeks. Participants also received a placebo capsule to match ramipril once a day for the study duration. arm 2: For the first 2 weeks of the study participants received 5 mg ramipril orally once a day and were then forced titrated to ramipril 10 mg once a day for 52 weeks. Participants also received placebo to aliskiren for the duration of the study.

Interventions: intervention 1: Aliskiren intervention 2: Ramipril intervention 3: Placebo to Ramipril intervention 4: Placebo to Aliskiren
Intervention descriptions: intervention 1: Aliskiren 300 mg once a day intervention 2: Ramipril 10 mg once a day intervention 3: Placebo capsules to match ramipril. intervention 4: Placebo tablets to match aliskiren.

Protocol document: