Conditions: Impaired Glucose Tolerance
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 50
Healthy volunteers: no

Brief summary:
The purpose of this study is to compare the effects of exenatide versus metformin on vascular health with chronic (3-month) therapy and during a 2-hour period following a meal in patients with pre-diabetes. It is predicted that exenatide will improve vascular health to a greater degree compared to metformin.

Detailed description:

Arms:
arm 1: Subjects were randomlly assigned to treatment arm: Exenatide 10 mcg twice daily vs. Metformin 500 mg twice daily. arm 2: Subjects were randomlly assigned to treatment arm: Exenatide 10 mcg twice daily vs. Metformin 500 mg twice daily.

Interventions: intervention 1: Exenatide intervention 2: Metformin
Intervention descriptions: intervention 1: exenatide 10 mcg twice daily intervention 2: metformin 500 twice daily

Protocol document: