Conditions: Marijuana Smoking
Keywords: naltrexone smoked marijuana marijuana use
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 23
Healthy volunteers: yes

Brief summary:
In heavy marijuana smokers, opioid receptor blockade increases the subjective and cardiovascular effects of marijuana. The current study was designed to clarify opioid-cannabinoid interactions by assessing how naltrexone shifts the dose-response function for marijuana-elicited effects in heavy marijuana smokers. For this within-subject, double-blind study, a marijuana smoking procedure was designed to characterize a dose-response relationship for marijuana's subjective and cardiovascular effects under blinded conditions.

Detailed description:

Arms:
arm 1: Placebo naltrexone capsules (0mg), inactive marijuana (0% THC). Each study participant underwent 8 conditions in a randomized order. arm 2: Placebo naltrexone capsules (0mg), active marijuana (5.5% THC). Each study participant underwent 8 conditions in a randomized order. arm 3: Placebo naltrexone capsules (0mg), active marijuana (6.2% THC). Each study participant underwent 8 conditions in a randomized order. arm 4: Naltrexone capsules (12mg), active marijuana (5.5% THC). Each study participant underwent 8 conditions in a randomized order. arm 5: Naltrexone capsules (0mg), active marijuana (6.2% THC). Each study participant underwent 8 conditions in a randomized order. arm 6: Naltrexone capsules (12mg), inactive marijuana (0% THC). Each study participant underwent 8 conditions in a randomized order.

Interventions: intervention 1: Inactive Marijuana (0% THC) intervention 2: Active Marijuana (5.5% THC) intervention 3: Active Marijuana (6.2% THC) intervention 4: Naltrexone intervention 5: Placebo naltrexone
Intervention descriptions: intervention 1: Marijuana cigarette containing 0% THC intervention 2: Marijuana cigarette containing 5.5% THC intervention 3: Marijuana cigarette containing 6.2% THC intervention 4: Naltrexone (12mg/70kg) intervention 5: Naltrexone (0mg)

Protocol document: