Conditions: Cocaine Dependence
Keywords: cocaine crack cocaine cocaine-related disorders substance-related disorders alpha4beta2 nicotinic acetylcholine receptor
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 37
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine whether varenicline (Chantix), is effective for the treatment of cocaine dependence.

Detailed description:
The purpose of study is to determine if Varenicline (Chantix™) promotes cocaine abstinence in cocaine dependent individuals. Varenicline (Chantix™) (2.0 mg/day) or placebo will be administered in a 9-week double-blind trial to patients meeting diagnostic criteria for cocaine dependence.

Arms:
arm 1: Varenicline (Chantix) arm 2: Placebo

Interventions: intervention 1: varenicline intervention 2: placebo
Intervention descriptions: intervention 1: 1.0 mg BID for 8 weeks intervention 2: placebo BID for 8 weeks

Protocol document: