Conditions: Healthy
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 64
Healthy volunteers: yes

Brief summary:
The objective of the current study is to establish the bioequivalence of linagliptin/ pioglitazone fixed dose combination tablet compared to single tablets of linagliptin and pioglitazone administered together.

Detailed description:

Arms:
arm 1: Fixed-Dose-Combination-Tablet, oral administration with 240 mL water arm 2: Tablets, oral administration with 240 mL water for each treatment arm 3: Fixed-Dose-Combination-Tablet, oral administration with 240 mL water arm 4: Tablets, oral administration with 240 mL water for each treatment

Interventions: intervention 1: Linagliptin + Pioglitazone intervention 2: Linagliptin + Pioglitazone intervention 3: Linagliptin/Pioglitazone intervention 4: Linagliptin/Pioglitazone
Intervention descriptions: intervention 1: Medium doses, oral administration intervention 2: Medium doses, oral administration intervention 3: Medium dose oral administration intervention 4: Medium dose oral administration

Protocol document: