Conditions: Multiple Sclerosis
Keywords: multiple sclerosis testosterone
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 10
Healthy volunteers: no

Brief summary:
Since men are less likely to develop multiple sclerosis, the hypothesis was that testosterone might be protective in MS. Men with MS for followed untreated for 6 months, followed by a 12 month treatment period with Androgel.

Detailed description:
Background: Men are less susceptible to many autoimmune diseases including multiple sclerosis (MS). Possible causes for this include sex hormones and/or sex chromosome effects. Testosterone treatment ameliorates experimental allergic encephalomyelitis (EAE), an animal model of MS, but the effect of testosterone supplementation on men with MS is not known.

Design, Setting and Participants: Ten men with relapsing remitting MS were studied using a crossover design whereby each patient served as his own control. There was a six-month pretreatment period followed by a twelve month period of daily treatment with 100mg of testosterone gel.

Main Outcome Measures: Brain atrophy and Cognitive testing

Arms:
arm 1: 6 months pretreatment, 12 months treatment intervention with Androgel 10 grams of gel containing 100mg of testosterone

Interventions: intervention 1: Androgel 10 grams of gel containing 100 mg of testosterone
Intervention descriptions: intervention 1: testosterone gel

Protocol document: