Conditions: Abscess Methicillin-Resistant Staphylococcus Aureus Infection
Keywords: Abscess Cellulitis Antibiotics MRSA
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 139
Healthy volunteers: yes

Brief summary:
Patients will be enrolled in a multi-center study (Wilford Hall Medical Center and Brooke Army Medical Center) to prospectively evaluate outcome after treatment for an uncomplicated skin abscess.

Detailed description:
All patients will receive incision and drainage and wound cultures. Patients will then be randomized to 1) septa double strength two pills orally twice a day x 7 days or 2)placebo. Patients will then return to the emergency room on days 3 and 7 for wound repacking and evaluation. The primary outcome recurrence rates within 30 days of treatment. Patients who are not improving at the following visit will then be treated with additional antibiotics if needed. Data will be analyzed both by initial randomization and intention to treat.

Arms:
arm 1: Trim/sulfa (800/160) two tablets orally (PO) twice a day (BID) x 7 days arm 2: matched placebo 2 pills orally (PO) twice a day (BID) x 7 days

Interventions: intervention 1: Trim/ Sulfa DS intervention 2: placebo
Intervention descriptions: intervention 1: bactrim DS (800/160) two tablets PO BID x 7 days intervention 2: matched placebo 2 pills PO BID x 7 days

Protocol document: