Conditions: Attention Deficit Hyperactivity Disorder Reading Disorder
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 121
Healthy volunteers: yes

Brief summary:
To test the hypothesis that a 4 week treatment with atomoxetine is more effective than placebo in patients with combined type Attention Deficit/Hyperactivity Disorder (ADHD), patients with only Reading Disorder, and patients with combined type ADHD and Reading Disorder.

Detailed description:

Arms:
arm 1: Atomoxetine, 1.2 mg/kg/day, by mouth (PO) for 4 weeks, 2 week washout period and cross-over to placebo, every day (QD), PO for 4 weeks arm 2: Placebo, every day (QD), by mouth (PO) for 4 weeks, 2 week washout period and cross-over to atomoxetine 1.2 mg/kg/day, PO for 4 weeks arm 3: Normal controls were children selected from the general population. The normal control was matched (have same proportion) by sex (male/female) and by age (have same age range) as the study population. arm 4: The reading disordered control group is comprised of children with reading disorder who receive standard remedial teaching therapy.

Interventions: intervention 1: Atomoxetine Hydrochloride intervention 2: placebo
Intervention descriptions: intervention 1: Atomoxetine, 1.2 mg/kg/day, by mouth (PO) intervention 2: Placebo, every day (QD), by mouth (PO)

Protocol document: