Conditions: Bipolar Depression
Keywords: Ceftriaxone Acute Antidepressant Effects Glutamatergic System Double-Blind Mood Disorders Bipolar Disorder Depression Affective Disorders
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 5
Healthy volunteers: no

Brief summary:
We aim to study the efficacy of intravenous ceftriaxone in a four-week, inpatient, placebo-controlled, double-blind study, as an augmentation therapy in patients with bipolar disorder, currently depressed, who have failed to respond to conventional treatments.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: ceftriaxone intervention 2: Saline solution
Intervention descriptions: intervention 1: 2g per day which will be administered IV via midline, 7 days a week for 4 weeks. intervention 2: Saline solution will be administered IV via midline, 7 days a week for 4 weeks.

Protocol document: