Conditions: Hypertension
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 13
Healthy volunteers: no

Brief summary:
This study will qualify a functional model that can measure central blood pressure and vascular compliance effects through noninvasive means.

Detailed description:

Arms:
arm 1: losartan 100 mg arm 2: ISMN 60 mg arm 3: losartan 100 mg + ISMN 15 mg arm 4: losartan 100 mg + ISMN 60 mg arm 5: Placebo

Interventions: intervention 1: losartan potassium intervention 2: Comparator: isosorbide mononitrate (ISMN) intervention 3: Comparator: losartan + ISMN intervention 4: Comparator: losartan + ISMN intervention 5: Comparator: Placebo
Intervention descriptions: intervention 1: Single dose losartan 100 mg in one of five treatment periods intervention 2: Single dose ISMN 60 mg in one of five treatment periods intervention 3: Single dose losartan 100 mg and ISMN 15 mg in one of five treatment periods intervention 4: Single dose losartan 100 mg and ISMN 60 mg in one of five treatment periods intervention 5: Single dose placebo only in one of five treatment periods

Protocol document: