Conditions: Pre-diabetes
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 53
Healthy volunteers: yes

Brief summary:
The purpose of this research study is to examine if a combination of a cholesterol lowering-drug, simvastatin, with a sugar-lowering drug called rosiglitazone is more effective in improving vascular inflammation (irritation of the vessels that transport your blood) and other cardiovascular risk factors than the taking of simvastatin alone.

Detailed description:
Age 21-75 years Metabolic syndrome (must have 3 of the 5 components) elevated waist circumference \>40inches in men, \>35 inches in women elevated triglycerides \>150mg/dL reduced HDL \<40mg/dL in men\<50 in women elevated blood pressure \>130mmHg systolic, or \>85mmHg diastolic elevated fasting glucose \>100mg/dL

Arms:
arm 1: Subjects will receive 40 mg Simvastatin + 1 tab Placebo Rosiglitazone daily arm 2: Subjects will receive 40 mg Simvastatin + 4 mg Rosiglitazone once daily

Interventions: intervention 1: Rosiglitazone intervention 2: Placebo Rosiglitazone intervention 3: Simvastatin
Intervention descriptions: intervention 1: 4 mg daily intervention 2: 1 tab daily intervention 3: 40 mg daily

Protocol document: