Conditions: Ecchymosis
Keywords: Bruising Topical 20% arnica
Allocation: RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 16
Healthy volunteers: yes

Brief summary:
The objective of this study is to assess the comparative utility of topical formulations in hastening the resolution of skin bruising. For each subject, four standard bruises of 7 mm diameter each were created on the bilateral upper inner arms, 5 cm apart, two per arm, using a 595-nm pulsed-dye laser. Randomization was used to assign one topical agent (5% vitamin K, 1% vitamin K and 0.3% retinol, 20% arnica or white petrolatum) to exactly one bruise per subject, which was then treated under occlusion twice a day for 2 weeks. A dermatologist rated bruises in standardized photographs immediately after bruise creation and at week 2.

Detailed description:

Arms:
arm 1: Bruises at three time points: immediate after bruise creating, and at 1 and 2 weeks.

Interventions: intervention 1: Petrolatum United States Pharmacopeia (USP) intervention 2: Vitamin K and retinol ointment intervention 3: Arnica ointment intervention 4: Vitamin K ointment
Intervention descriptions: intervention 1: Topical formation applied to bruise twice daily for 2 weeks. intervention 2: Topical formation applied to bruise twice daily for 2 weeks. intervention 3: Topical formation applied to bruise twice daily for 2 weeks. intervention 4: Topical formation applied to bruise twice daily for 2 weeks.

Protocol document: