Conditions: Obstetric Labor, Premature
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 192
Healthy volunteers: no

Brief summary:
To compare intravenous magnesium sulfate to oral nifedipine for acute tocolysis of preterm labor

Detailed description:

Arms:
arm 1: Preterm labor treatment with Magnesium Sulfate. arm 2: Preterm labor treatment with Nifedipine.

Interventions: intervention 1: Magnesium Sulfate intervention 2: Nifedipine
Intervention descriptions: intervention 1: Preterm labor treatment with Magnesium Sulfate 4 gram bolus followed by 2 gm per hour infusion. 2 Gm bolus as needed and/or rate increase up to 4gm per hour were allowed at the discretion of the treating physician. intervention 2: Preterm labor treatment with Nifedipine 10 mg. sublingually every 20 minutes for three doses, followed by 20 mg. orally every 4 or 6 hours.

Protocol document: