Conditions: Diabetes Mellitus, Type 2
Keywords: Type 2 diabetes intravenous single dose
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 84
Healthy volunteers: no

Brief summary:
This is a trial in subjects with Type 2 diabetes mellitus to study the safety, tolerability and pharmacokinetics and pharmacodynamics of single escalating doses of PF-05231023.

Detailed description:

Arms:
arm 1: None arm 2: 0.9% w/v sodium chloride injection, USP

Interventions: intervention 1: PF-05231023 intervention 2: PF-05231023 intervention 3: PF-05231023 intervention 4: PF-05231023 intervention 5: PF-05231023 intervention 6: PF-05231023 intervention 7: PF-05231023 intervention 8: Placebo
Intervention descriptions: intervention 1: 0.5 mg QD IV x 1 day intervention 2: 1.5 mg QD IV x 1 day intervention 3: 5 mg QD IV x 1 day intervention 4: 15 mg QD IV x 1 day intervention 5: 50 mg QD IV x 1 day intervention 6: 100 mg QD IV x 1 day intervention 7: 200 mg QD IV x 1 day intervention 8: 0.9% w/v sodium chloride injection, USP QD IVx 1 day

Protocol document: