Conditions: Renal Impairment
Keywords: CP-690 550 pharmacokinetics renal impairment
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 24
Healthy volunteers: yes

Brief summary:
A study to evaluate the pharmacokinetics of CP-690,550 in subjects with mild, moderate or severe renal impairment, who do not require hemodialysis, compared to healthy controls.

Detailed description:

Arms:
arm 1: Healthy volunteers arm 2: patients with mild (\>50 and ≤80 mL/min) renal impairment arm 3: patients with moderate (≥30 and ≤50 mL/min) renal impairment arm 4: patients with severe (\<30 mL/min) renal impairment

Interventions: intervention 1: CP-690,550 intervention 2: CP-690,550 intervention 3: CP-690,550 intervention 4: CP-690,550
Intervention descriptions: intervention 1: 10 mg (2 x 5 mg tablets), single dose intervention 2: 10 mg (2 x 5 mg tablets), single dose intervention 3: 10 mg (2 x 5 mg tablets), single dose intervention 4: 10 mg (2 x 5 mg tablets), single dose

Protocol document: