Conditions: Anti-biotic Resistance
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 66
Healthy volunteers: yes

Brief summary:
The purpose of this study is to assess if the presence of BAK in a fluoroquinolone in the study eye affects the development of resistant bacteria on the conjunctiva based upon changes in the surface flora over the course of 2 weeks of topical treatment in healthy adult subjects.

Detailed description:

Arms:
arm 1: moxifloxacin 0.5% (m mg/mL), boric acid, sodium chloride, and purified water arm 2: gatifloxacin 0.3% (3 mg/mL), benzalkonium chloride 0.005%, edetate disodium; purified water and sodium chloride

Interventions: intervention 1: moxifloxacin 0.5% HCI ophthalmic solution intervention 2: gatifloxacin ophthalmic solution 0.3%
Intervention descriptions: intervention 1: 1 drop in study eye three times a day for 14 days intervention 2: 1 drop in study eye four times a day for 14 days

Protocol document: