Conditions: Pulmonary Arterial Hypertension
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 8
Healthy volunteers: no

Brief summary:
6 months therapy of Bosentan, an endothelin antagonist, will lead to improvement in pulmonary microvascular endothelial function.

Detailed description:

Arms:
arm 1: 62.5 mg Bosentan twice a day for 1 month 125 mg Bosentan twice a day for 5 months

Interventions: intervention 1: Bosentan
Intervention descriptions: intervention 1: 62.5 mg Bosentan twice a day for 1 month 125 mg Bosentan twice a day for 5 months

Protocol document: