Conditions: Congestive Heart Failure
Keywords: metabolism congestive heart failure allopurinol Adenosine triphosphate (ATP)
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 18
Healthy volunteers: no

Brief summary:
This study tests the hypothesis that allopurinol, a xanthine oxidase inhibitor, improves heart metabolism in patients with heart failure.

Detailed description:
Xanthine oxidase have been reported to improve mechano-energetic coupling in failing hearts. The investigators developed a means to directly measure creatine kinase flux, the major energy reserve of the heart, in the human heart exploiting new magnetic resonance technologies.

The investigators propose to study 10 healthy subjects and up to 25 with heart failure (dilated cardiomyopathy) before and after a single 300mg IV infusion of allopurinol.

Arms:
arm 1: One time intravenous administration of Allopurinol 300 mg infused over approximately 20 minutes. arm 2: One time intravenous administration of 50 ml dose of 5% dextrose infused over approximately 20 minutes.

Interventions: intervention 1: Allopurinol intervention 2: Placebo
Intervention descriptions: intervention 1: intravenous infusion of allopurinol (300mg) intervention 2: intravenous infusion of 50 ml dose of 5% dextrose

Protocol document: