Conditions: Malignant Melanoma Recurrent Melanoma
Allocation: RANDOMIZED | Intervention model: FACTORIAL
Enrollment: 269
Healthy volunteers: no

Brief summary:
This study evaluated two chemotherapy regimens with and without the addition of interferon in patients with advanced or recurrent melanoma.

Detailed description:

Arms:
arm 1: combination chemotherapy without interferon arm 2: combination chemotherapy with interferon arm 3: single agent dacarbazine without interferon arm 4: single agent dacarbazine plus interferon

Interventions: intervention 1: Dacarbazine intervention 2: Fotemustine intervention 3: Interferon Alfa-2b
Intervention descriptions: intervention 1: 900 mg / m2 every 3 weeks intervention 2: 100 mg / m2 every 3 weeks intervention 3: 5 M units every 3 weeks

Protocol document: