Conditions: Fibromyalgia
Keywords: fibromyalgia milnacipran Forest Laboratories
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 2
Healthy volunteers: no

Brief summary:
The purpose of this study is to evaluate the effect of milnacipran on how the brain processes pain in patients with fibromyalgia and to assess the relationship between this effect and brain activation patterns during functional magnetic resonance imaging.

Detailed description:

Arms:
arm 1: Twice daily oral administration of milnacipran for 5 weeks, placebo for 2 weeks, and crossover to placebo for 5 weeks. arm 2: Twice daily oral administration of placebo for 5 weeks, placebo for 2 weeks, and crossover to milnacipran for 5 weeks.

Interventions: intervention 1: Milnacipran intervention 2: Placebo intervention 3: Placebo intervention 4: Milnacipran
Intervention descriptions: intervention 1: Twice daily oral administration of Milnacipran for 5 weeks. intervention 2: Twice daily oral administration of placebo for 5 weeks. intervention 3: Twice daily oral administration of placebo for 5 weeks. intervention 4: Twice daily oral administration of Milnacipran for 5 weeks.

Protocol document: