Conditions: Osteoarthritis of the Knee
Keywords: osteoarthritis knee arthroplasty local infiltration analgesia TKA epidural analgesia operation surgery
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 102
Healthy volunteers: no

Brief summary:
Total knee arthroplasty (TKA) is associated with moderate to severe postoperative pain, causing patient discomfort, mobilisation and hospital discharge.

The aim of this study is to:

1. Compare analgetic efficacy of to types of local infiltration analgesia in total knee arthroplasty.
2. Compare analgetic efficacy of local infiltration analgesia with continuous epidural analgesia.

Detailed description:
Total knee arthroplasty (TKA) is increasingly common in the treatment of knee osteoarthritis. TKA is associated with moderate to severe postoperative pain, causing patient discomfort, mobilisation and hospital discharge.

Continuous epidural analgesia is often used for controlling pain after TKA. Recent studies describe a new method for pain control after total knee arthroplasty which consists of local infiltration with local anesthetics and adrenaline. This infiltrations can be combined with ketorolac and/or morphine. The aim of this study is to:

1. Compare analgetic efficacy of to types of local infiltration analgesia in total knee arthroplasty.
2. Compare analgetic efficacy of local infiltration analgesia with continuous epidural analgesia.

Arms:
arm 1: Local infiltration analgesia with ropivacaine and adrenaline and intravenous ketorolac and morphine arm 2: Local infiltration analgesia with ropivacaine, adrenaline and ketorolac and morphine arm 3: standard continuous epidural analgesia

Interventions: intervention 1: ropivacaine intervention 2: adrenaline intervention 3: ketorolac intervention 4: morphine intervention 5: fentanyl intervention 6: bupivacaine
Intervention descriptions: intervention 1: intraoperative and 1. postoperative day intervention 2: intraoperative LIA (IV and IA) and continuous EDA intervention 3: intraoperative and 1. postoperative day intervention 4: intraoperative intervention 5: continuous postoperatively intervention 6: continuous postoperatively

Protocol document: