Conditions: Asthma
Keywords: Salmeterol fluticasone furoate Vilanterol fluticasone propionate GW642444
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 810
Healthy volunteers: no

Brief summary:
The purpose of the study is to compare the efficacy and safety of fluticasone furoate/vilanterol (GW642444) inhalation powder administered once daily with fluticasone propionate/salmeterol administered twice daily in adolescent and adult subjects 12 years of age and older with persistent bronchial asthma over a 24-week period.

Detailed description:

Arms:
arm 1: Fluticasone furoate/vilanterol inhalation powder once daily + placebo inhalation powder twice daily for 24 weeks arm 2: Fluticasone propionate/salmeterol inhalation powder twice daily + placebo inhalation powder once daily for 24 weeks

Interventions: intervention 1: Fluticasone furoate/Vilanterol Inhalation Powder intervention 2: Fluticasone propionate/salmeterol Inhalation Powder intervention 3: Placebo (1) intervention 4: Placebo (2)
Intervention descriptions: intervention 1: Fluticasone furoate/Vilanterol Inhalation Powder inhaled orally once daily for 24 weeks intervention 2: Fluticasone propionate/salmeterol Inhalation Powder inhaled orally twice daily for 24 weeks intervention 3: Inhalation powder inhaled orally once daily for 24 weeks intervention 4: Inhalation powder inhaled orally twice daily for 24 weeks

Protocol document: