Conditions: Epilepsy
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 13
Healthy volunteers: yes

Brief summary:
Multiple-dose, open-label, single-period study consisting of three consecutive phases

Detailed description:
Multiple-dose, open-label, single-period study consisting of three consecutive phases: Phase A - run-in warfarin dose-finding phase Phase B - warfarin pharmacokinetics (PK) and international normalised ratio (INR) profiling Phase C - warfarin alone at their individualised doses

Arms:
arm 1: Phase A: Warfarin Phase B: Warfarin + BIA 2-093 (ESL) Phase C: Warfarin

Interventions: intervention 1: BIA 2-093 intervention 2: Warfarin
Intervention descriptions: intervention 1: None intervention 2: None

Protocol document: