Conditions: Endothelial Function Lipids Insulin Resistance Inflammation HIV Infections
Keywords: HIV Endothelial function Etravirine
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 28
Healthy volunteers: yes

Brief summary:
The purpose of this study is to determine the safety and effects of etravirine, an HIV antiretroviral medication, on vascular function.

Detailed description:
We hypothesize that in HIV-uninfected subjects, etravirine 200mg twice daily for four weeks will have no effect on endothelial function. The primary objective of this study is to determine the effects of etravirine 200mg twice daily given for four weeks on endothelial function, measured as flow-mediated dilation (FMD) of the brachial artery, in HIV-uninfected subjects. Secondary objectives include determination of the effects of etravirine 200mg twice daily given for four weeks on safety measures, lipid fractions, HOMA-IR, blood pressure, inflammatory parameters, and endothelial activation parameters.

Arms:

Interventions: intervention 1: Etravirine
Intervention descriptions: intervention 1: Two one-hundred mg tablets orally twice daily for four weeks

Protocol document: