Conditions: Biliary Tract Surgical Procedures Pancreaticoduodenectomy Esophagectomy Colectomy Gastrectomy
Keywords: tranexamic acid major abdominal surgery blood loss
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 94
Healthy volunteers: no

Brief summary:
Tranexamic acid has been shown to reduce postoperative blood losses and transfusion requirements in various types of major surgery (orthopedic surgery, spine surgery, cardiopulmonary bypass, liver resections, and gynecological cancers).The current trial is being conducted to compare the efficacy of tranexamic acid plus standard of care versus standard of care in reduction of blood loss in patients undergoing major abdominal surgeries.

Detailed description:

Arms:
arm 1: end of the operation and on the mornings of the first, second, fourth and seventh postoperative days. arm 2: Standard of Care

Interventions: intervention 1: Tranexamic acid + Standard of Care intervention 2: Standard of Care
Intervention descriptions: intervention 1: Tranexamic acid given slowly intravenously (15 mg/kg body weight) 15 minutes before surgery followed by a second dose at three hour interval from first dose and third dose at three hour interval from the second + standard of care (Standard of care includes the routine surgical and anesthetic techniques being utilized to control blood loss) intervention 2: Standard of care includes the routine surgical and anesthetic techniques being utilized to control blood loss

Protocol document: