Conditions: Heart Failure
Keywords: Heart failure, aliskiren, furosemide, diuretic efficacy, interaction
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 37
Healthy volunteers: no

Brief summary:
This study assessed the interaction between single and multiple doses of aliskiren (150 mg and 300 mg) and furosemide (60 mg) in patients with heart failure.

Detailed description:

Arms:
arm 1: Treatment period 1 (Day 1 to Day 7): All eligible patients received 60 mg furosemide, 150 mg placebo of aliskiren, and 300 mg placebo aliskiren once daily. arm 2: Treatment Period 2 (Day 8 to day 17): Patients received 60 mg furosemide, 150 mg aliskiren and 300 mg placebo once daily. arm 3: Treatment Period 3 (Day 18 to day 27): Patients received 60 mg furosemide, 300 mg aliskiren and 150 mg placebo of aliskiren once daily.

Interventions: intervention 1: Aliskiren 150 mg intervention 2: Furosemide 60 mg intervention 3: Placebo for Aliskiren intervention 4: Aliskiren 300 mg
Intervention descriptions: intervention 1: Aliskiren 150 mg tablet intervention 2: Furosemide 60 mg commercially-available tablets intervention 3: Matching placebo for aliskiren 150 mg and 300 mg intervention 4: Aliskiren 300 mg tablet

Protocol document: