Conditions: Skin and Soft Tissue Infections
Keywords: outpatient skin and soft tissue infections vancomycin intravenous
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 4
Healthy volunteers: no

Brief summary:
Our hypothesis is that large-dose, extended-interval vancomycin (30 mg/kg IV q24h) administration provides non-inferior clinical efficacy and microbiological efficacy to standard vancomycin (15 mg/kg IV q12h) administration for skin and soft tissue infections in an outpatient setting.

Detailed description:

Arms:
arm 1: Subject receives vancomycin 30 mg/kg dose arm 2: Subject receives vancomycin 15 mg/kg twice daily

Interventions: intervention 1: vancomycin intervention 2: vancomycin
Intervention descriptions: intervention 1: vancomycin 30 mg/kg intravenous administered once daily intervention 2: vancomycin 15 mg/kg intravenous administered twice daily (standard dosing)

Protocol document: