Conditions: Psoriasis Vulgaris
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 24
Healthy volunteers: no

Brief summary:
The purpose of this trial is to evaluate the anti-psoriatic effect of LEO 29102 cream and its combination with calcipotriol and betamethasone using a psoriasis plaque test method.

Detailed description:

Arms:
arm 1: LEO 29102 2.5 mg/g cream applied topically twice daily for 4 weeks arm 2: LEO 29102 cream vehicle applied topically twice daily for 4 weeks. arm 3: Betamethasone 0.5 mg/g (as dipropionate) cream applied topically twice daily for 4 weeks. arm 4: LEO 29102 2.5 mg/g plus calcipotriol 50mcg/g cream applied topically twice daily for 4 weeks. arm 5: LEO 29102 2.5 mg/g plus betamethasone 0.5 mg/g (as dipropionate) cream applied topically twice daily for 4 weeks. arm 6: Daivobet® ointment, combination of calcipotriol 50 mcg/g plus betamethasone 0.5 mg/g (as dipropionate) applied topically twice daily for 4 weeks.

Interventions: intervention 1: LEO 29102 cream intervention 2: LEO 29102 Cream Vehicle intervention 3: Betamethasone Dipropionate Cream intervention 4: LEO 29102 Plus Calcipotriol Cream intervention 5: LEO 29102 Plus Betamethasone Dipropionate intervention 6: Daivobet® Ointment
Intervention descriptions: intervention 1: None intervention 2: None intervention 3: None intervention 4: None intervention 5: None intervention 6: None

Protocol document: