Conditions: Essential Hypertension ( Mild to Moderate)
Keywords: Essential Hypertension ( mild to moderate)
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 256
Healthy volunteers: no

Brief summary:
This study will assess the efficacy of an aliskiren based treatment regimen in reaching blood pressure (BP) target in patients with mild to moderate hypertension. (defined as mean sitting Systolic Blood Pressure \[msSBP\] ≥ 140 mmHg and \< 180 mmHg and/or mean sitting Diastolic Blood Pressure \[msDBP\] ≥ 90 and \<110 mmHg).

Detailed description:

Arms:
arm 1: All pts starting on aliskiren 150 mg (uptitrated to aliskiren 300 mg), followed by the addition of HCTZ 12.5 mg (uptitrated to 25 mg) and amlodipine 5 mg (uptitrated to 10 mg), as necessary to achieve the Blood Pressure goal.

Interventions: intervention 1: Aliskiren intervention 2: Hydrochlorothiazide intervention 3: Amlodipine
Intervention descriptions: intervention 1: Aliskiren 150 or 300 mg intervention 2: Hydrochlorothiazide 12.5 or 25 mg intervention 3: Amlodipine 5 or 10 mg

Protocol document: