Conditions: Plaque Psoriasis
Keywords: plaque psoriasis alefacept Amevive narrow band ultraviolet B phototherapy
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 98
Healthy volunteers: no

Brief summary:
Assess the efficacy and safety of alefacept with nbUVB compared to alefacept alone in chronic plaque psoriasis subjects. Combination therapy may improve the clinical response to psoriatic subjects as both modalities have an effect on T cells

Detailed description:

Arms:
arm 1: 15 mg alefacept intramuscularly (IM) once weekly for 12 weeks arm 2: 15 mg alefacept intramuscularly once weekly and narrow band Ultraviolet B (nbUVB) phototherapy 3 times per week for 12 weeks

Interventions: intervention 1: alefacept intervention 2: Narrow Band UVB Phototherapy
Intervention descriptions: intervention 1: IM intervention 2: UVB Phototherapy

Protocol document: