Conditions: Meibomian Gland Dysfunction
Keywords: Meibomian Gland Dysfunction Dry Eye Syndrome
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 60
Healthy volunteers: no

Brief summary:
The objective of this study is to assess the safety and efficacy of testosterone 0.03% ophthalmic solution compared to vehicle for the treatment of meibomian gland dysfunction.

Detailed description:
Meibomian gland secretion plays a crucial role in the health of the ocular surface and function of the tear film. The lipid secreted by the meibomian glands has many crucial roles: 1) to retard evaporation from the preocular surface; 2) lower the surface tension of tears; 3) prevent spill-over of tears from the lid margin; 4) prevent the contamination of the tear film by sebaceous lipids; 5) prevent damage to the skin of the lid margin. In dry eye syndrome, blepharitis, meibomian gland dysfunction, and meibomitis the glands are the central pathophysiology of disease and thus a potential target for therapy.

Arms:
arm 1: testosterone ophthalmic solution 0.03% arm 2: vehicle of testosterone ophthalmic solution

Interventions: intervention 1: testosterone ophthalmic solution intervention 2: vehicle of testosterone ophthalmic solution
Intervention descriptions: intervention 1: testosterone ophthalmic solution for 128 days intervention 2: vehicle of testosterone ophthalmic solution for 128 days

Protocol document: