Conditions: Arthritis Osteoarthritis
Keywords: monoclonal antibody RN624 PF-04383119 nerve growth factor anti-nerve growth factor OA pain
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 832
Healthy volunteers: no

Brief summary:
The purpose of this study is to test the efficacy and safety of 2 doses of tanezumab compared with naproxen and placebo in patients with osteoarthritis.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None arm 4: None

Interventions: intervention 1: tanezumab 10 mg intervention 2: tanezumab 5 mg intervention 3: naproxen intervention 4: placebo
Intervention descriptions: intervention 1: tanezumab 10 mg one dose at weeks 0 and 8 intervention 2: tanezumab 5 mg one dose at weeks 0 and 8 intervention 3: naproxen 1000 mg daily for 16 weeks intervention 4: placebo to match tanezumab and naproxen dosing

Protocol document: