Conditions: Osteoarthritis
Keywords: Osteoarthritis, intra articular steroids
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 25
Healthy volunteers: no

Brief summary:
Oral and nasal steroids may enhance osteoporosis by suppressing bone formation. Intra-articular steroids may also suppress bone formation, however, the duration or relationship to a steroid dose has not been established. It is hypothesized that intra-articular steroids suppress bone formation transiently, returning to pretreatment levels within four weeks in subjects with osteoarthritis.

Detailed description:
Oral and nasal steroids may enhance osteoporosis by suppressing bone formation. Intra-articular steroids may also suppress bone formation, however, the duration or relationship to a steroid dose has not been established. It is hypothesized that intra-articular steroids suppress bone formation transiently, returning to pretreatment levels within four weeks in subjects with osteoarthritis. The purpose of the study is to determine if intra-articular steroids suppress markers of bone formation or resorption in osteoarthritis patients and whether these markers may be modified by Vitamin D or Dual-energy X-ray absorptiometry (DEXA) bone density status

Arms:
arm 1: Methylprednisone 80 mg and Lidocaine 20 mg arm 2: Methylprednisolone 16 mg and Lidocaine 20 mg arm 3: Placebo and Lidocaine 20 mg

Interventions: intervention 1: Methylprednisolone and Lidocaine intervention 2: Methylprednisolone and Lidocaine intervention 3: Placebo and Lidocaine
Intervention descriptions: intervention 1: Methylprednisolone 80 mg, intra-articular and lidocaine 20 mg intervention 2: Methylprednisolone 16 mg intra-articular and lidocaine 20 mg intervention 3: Placebo and lidocaine 20 mg

Protocol document: