Conditions: Chronic Obstructive Pulmonary Disease
Keywords: COPD
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 137
Healthy volunteers: no

Brief summary:
The purpose of this study is to investigate the effect on exercise tolerance, lung function and symptoms after treatment with Symbicort, Oxis or placebo in patients with severe chronic obstructive pulmonary disease.

Detailed description:

Arms:
arm 1: Symbicort (budesonide/formoterol) Turbuhaler 320/9 micrograms, 1 inhalation twice daily, then Formoterol Turbuhaler 9 micrograms, 1 inhalation twice daily, then Placebo, 1 inhalation twice daily arm 2: Formoterol Turbuhaler 9 micrograms, 1 inhalation twice daily, then Symbicort (budesonide/formoterol) Turbuhaler 320/9 micrograms, 1 inhalation twice daily, then Placebo, 1 inhalation twice daily arm 3: Placebo, 1 inhalation twice daily, then Formoterol Turbuhaler 9 micrograms, 1 inhalation twice daily, then Symbicort (budesonide/formoterol) Turbuhaler 320/9 micrograms, 1 inhalation twice daily

Interventions: intervention 1: budesonide/formoterol Turbuhaler 320/9µg intervention 2: formoterol Turbuhaler 9µg intervention 3: Placebo
Intervention descriptions: intervention 1: Symbicort (budesonide/formoterol) Turbuhaler 320/9 micrograms intervention 2: Formoterol Turbuhaler 9 micrograms, 1 inhalation twice daily intervention 3: Placebo, 1 inhalation twice daily

Protocol document: