Conditions: Alcoholism
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 68
Healthy volunteers: no

Brief summary:
The purpose of this study is to develop and validate a human laboratory model for prediction of medication efficacy in clinical trials for relapse prevention in alcohol dependence.

Detailed description:
This is a double-blind, 3-cell, outpatient human laboratory study to determine the degree to which acamprosate and naltrexone will suppress subjective and physiological responsivity to alcohol cues relative to placebo in early abstinence.

Arms:
arm 1: Acamprosate arm 2: Naltrexone arm 3: None

Interventions: intervention 1: Acamprosate intervention 2: Naltrexone intervention 3: Placebo
Intervention descriptions: intervention 1: Two 333mg capsules, 3 times daily (Total dose, 1998 mg daily), 1 week duration intervention 2: 50mg capsule, Once daily, 1 week duration intervention 3: Matched placebo capsule, 1 week duration

Protocol document: