Conditions: Variceal Bleeding, Cirrhosis
Keywords: Cirrhosis, Esophagus Disorders, Varicose Veins
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 1034
Healthy volunteers: no

Brief summary:
This study is performed to compare the efficacy of terlipressin, somatostatin, and octreotide in patients with variceal bleeding for the control of variceal bleeding in combination with endoscopic therapy.

Detailed description:
In patients who are suspected to have variceal bleedings, pharmacologic therapy with vasoactive drugs such as terlipressin, somatostatin, and octreotide is recommended as soon as possible, even before endoscopy. However, it is still unclear whether the efficacies of these drugs are same or not. This study is performed to compare the efficacy of terlipressin, somatostatin, and octreotide in patients with variceal bleeding for the control of variceal bleeding in combination with endoscopic therapy.

Arms:
arm 1: treat with terlipressin IV for 5 days and endoscopic treatment arm 2: treat with somatostatin IV for 5 days and endoscopic treatment arm 3: treat with octreotide IV for 5 days and endoscopic treatment

Interventions: intervention 1: Terlipressin intervention 2: Somatostatin intervention 3: Octreotide
Intervention descriptions: intervention 1: loading with 2 mg IV, and then 1 mg IV every 4 hours for 5 days intervention 2: loading with 250 microgram IV, and then 250 microgram/hour continuous IV for 5 days intervention 3: loading with 50 microgram IV, and then 25 microgram/hour continuous IV for 5 days

Protocol document: