Conditions: Colorectal Cancer
Keywords: Colon Cancer Rectal Cancer
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 106
Healthy volunteers: no

Brief summary:
The purpose of this study is to assess the efficacy and safety of 2 doses of ZACTIMA™ (ZD6474) in combination with FOLFIRI vs FOLFIRI alone for the treatment of colorectal cancer in patients who have failed therapy with an oxaliplatin and fluoropyrimidine containing regimen.

Detailed description:

Arms:
arm 1: FOLFIRI + placebo vandetanib arm 2: FOLFIRI + low dose vandetanib arm 3: FOLFIRI + high dose vandetanib

Interventions: intervention 1: Vandetanib intervention 2: FOLFIRI
Intervention descriptions: intervention 1: once daily oral tablet two doses intervention 2: Intravenous infusion

Protocol document: