Conditions: Diabetes Mellitus
Keywords: Hyperlipidemia Proteinuria Diabetes Mellitus
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 353
Healthy volunteers: no

Brief summary:
The purpose of this study is to evaluate the effects of Crestor (rosuvastatin) and (Lipitor) atorvastatin on urinary protein excretion over 1 year in patients with Type 1 or 2 diabetes with moderate proteinuria and hypercholesterolaemia.

Detailed description:

Arms:
arm 1: Rosuvastatin 10 mg arm 2: Rosuvastatin 40 mg arm 3: Atorvastatin 80 mg

Interventions: intervention 1: Rosuvastatin intervention 2: Rosuvastatin intervention 3: Atorvastatin
Intervention descriptions: intervention 1: 10 mg oral dose administered once daily for 52 weeks intervention 2: 20 mg oral dose administered once daily for 4 weeks followed by 40 mg oral dose administered once daily for 48 weeks intervention 3: 40 mg oral dose administered once daily for 4 weeks followed by 80 mg oral dose administered once daily for 48 weeks

Protocol document: