Conditions: Anesthesia
Keywords: Anesthesia Induction Pain
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 100
Healthy volunteers: no

Brief summary:
The purpose of the study is to determine whether a modified propofol preparation shows any effect on the incidence of injection pain in adults undergoing elective surgery under general anesthesia.

Study hypothesis: The use of a modified propofol preparation will reduce the incidence of injection pain in the study group.

Detailed description:
Pain on injection is a most frequently reported side effect associated with the use of propofol for induction of anesthesia. Various measures have been taken to reduce the pain on injection, e.g. administration of lidocaine or fentanyl prior to propofol administration, mixture of lidocaine and propofol as well as cooling of the emulsion. Although pain on injection had been reduced with some of the above mentioned methods, they may not be regarded as a satisfactory solution of the problem.

Arms:
arm 1: Modified propofol (Propofol 0.5%) arm 2: Propofol 1%

Interventions: intervention 1: Propofol intervention 2: Propofol 1%
Intervention descriptions: intervention 1: Propofol (drug), intravenous, induction of anesthesia intervention 2: Propofol (drug), intravenous, induction of anesthesia

Protocol document: