Conditions: Stress Incontinence
Keywords: Urinary tract infection (UTI) suburethral sling Prevention Nitrofurantoin Prophylaxis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 161
Healthy volunteers: yes

Brief summary:
This project will determine whether post-operative prophylaxis with macrobid will decrease the incidence of postoperative urinary tract infection in women receiving sub-urethral slings for the treatment of urinary incontinence.

Detailed description:
This project will be a randomized, double blinded, placebo controlled clinical trial. The aim of the trial is to determine whether or not post-operative prophylaxis with macrobid will decrease the incidence of postoperative urinary tract infection in women receiving sub-urethral slings for the treatment of urinary incontinence.

Arms:
arm 1: Patients randomly assigned to be treated with nitrofurantoin 100mg PO BID x 3 days post-operatively arm 2: Arm randomly assigned to receive placebo 1 tablet PO BID x 3 days post-operatively.The incidence of UTI in this group will be compared with group one (1)

Interventions: intervention 1: Nitrofurantoin intervention 2: Placebo
Intervention descriptions: intervention 1: Nitrofurantoin 100mg PO BID for 3 days post operatively following the placement of a sub-urethral sling for the treatment of stress urinary incontinence intervention 2: 6 tablets to be taken 1 tablet PO BID. These tablets are identical to nitrofurantoin 100mg tablets.

Protocol document: