Conditions: Kidney Transplant
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 20
Healthy volunteers: no

Brief summary:
A study to determine the effect on renal function in renal transplant patients with biopsy proven Chronic allograft nephropathy (CAN) nephropathy who are switched from a Calcinerin inhibitor (CI) triple drug regimen to a Rapamycin based triple drug regimen or maintained on their CI protocol

Detailed description:

Arms:
arm 1: pt will switch from calcineurin inhibitor (CYA, prograf) to Rapamycin arm 2: Patient will remain on calcineruin inhibitor

Interventions: intervention 1: Rapamycin
Intervention descriptions: intervention 1: Rapamycin will start within 24 hours of last calcineurin inhibitors (Cya, Prograf). Initial dose of Rapamune 10mg will be given for 3 days and then dose will be adjusted to attain a target whole blood trough of 5-15

Protocol document: