Conditions: Spondylitis, Ankylosing SpA
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 7
Healthy volunteers: no

Brief summary:
Subjects will be given 3 infusions of infliximab according to the label at week 0, 2, and 6. Subjects will be followed for a maximum of 18 weeks or until relapse. This study will assess the ability of the Power Doppler Ultrasonography (PDUS) to be a reliable marker of enthesitis response and relapse in subjects treated with infliximab.

Detailed description:

Arms:
arm 1: Infliximab infusions: 5 mg/kg at weeks 0, 2, and 6.

Interventions: intervention 1: PDUS intervention 2: Infliximab
Intervention descriptions: intervention 1: PDUS scored for each enthesitis every 2 weeks for 24 weeks. intervention 2: * 5 mg/kg
* IV
* Frequency : weeks 0,2,6

Protocol document: