Conditions: Rheumatoid Arthritis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 29
Healthy volunteers: no

Brief summary:
To explore the effect of CP-690,550 on blood and synovial markers in subjects with rheumatoid arthritis. To evaluate the safety, tolerability and efficacy of CP-690,550.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: CP-690,550 + methotrexate intervention 2: Placebo + Methotrexate
Intervention descriptions: intervention 1: CP-690,550 dose is 10 mg twice daily, oral tablets, for 4 weeks Methotrexate dose is ≥ 7.5 mg / week and ≤ 25 mg / week intervention 2: Methotrexate dose is ≥ 7.5 mg / week and ≤ 25 mg / week

Protocol document: