Conditions: Chemotherapy-Induced Nausea and Vomiting
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 42
Healthy volunteers: yes

Brief summary:
This study will assess the bioequivalence of single oral doses of aprepitant (MK0869) to a single intravenous infusion of fosaprepitant (MK0517) and also determine the effect of food on the bioavailability of oral aprepitant.

Detailed description:

Arms:
arm 1: aprepitant 165 mg arm 2: aprepitant 185 mg arm 3: fosaprepitant 150 mg arm 4: aprepitant with food

Interventions: intervention 1: aprepitant 165 mg intervention 2: Comparator: aprepitant 185 mg intervention 3: Comparator: fosaprepitant 150 mg intervention 4: Comparator: aprepitant with food
Intervention descriptions: intervention 1: Single dose of aprepitant 165 mg tablet in the fasted state during treatment period 1,2, or 3. intervention 2: Single dose of aprepitant 185 mg tablet in the fasted state during treatment period 1, 2, or 3. intervention 3: Single dose of fosaprepitant 150 mg intravenous infusion in the fasted state during treatment period 1,2, or 3. intervention 4: Single dose of aprepitant 165 mg or 185 mg tablet in the fed state during treatment period 4.

Protocol document: