Conditions: Perennial Allergic Rhinitis
Keywords: Perennial Allergic rhinitis Traditional Chinese Medicine
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 126
Healthy volunteers: no

Brief summary:
Allergic rhinitis(AR) is one of the most common allergic disorders throughout the world.The conventional therapies are effective in alleviating symptoms but the efficacy are limited and not persistent. Furthermonre, the cost and side-effect are known defects. A classical Chinese herbal formula, has been used for AR for centries. Our study purpose is to evaluate the clinical efficacy and safety of this formula verus placebo in perennial allergic rhinitis (PAR).

Hypothesis: the classical herbal formula would improve the symptoms of PAR patients and change some immunological parameters in the peripheral blood when comparing with the placebo.

Detailed description:
It is a randomized, double-blind, placebo-controlled trial.

Arms:
arm 1: Consist of 6 herbal. 7.5 g Xanthium sibiricum Patrin ex Widder (Asteraceae, Fructus), 20 g Angelica dahurica (Fisch. ex Hoffm.) Benth. (Apiaceae, Radix), 7.5 g Saposhnikovia divaricata (Turcz.) Schischk. (Apiaceae, Radix),15 g Magnolia biondii Pamp., (Magnoliaceae, Flos), 5 g Gentiana scabra Bunge (Gentianaceae, Radix) and 5 g Verbena officinalis L. (Verbenaceae, Herba). arm 2: The placebo contained brown colored starch resembling the SBL powder

Interventions: intervention 1: Shi-Bi-Lin intervention 2: Placebo
Intervention descriptions: intervention 1: 4 weeks of treatment, dose of 1 g (two capsules), twice daily intervention 2: 4 weeks of colormatched placebo capsules, dose of 1 g (two capsules), twice daily

Protocol document: