Conditions: Intervertebral Disk Displacement Disk Prolapse
Keywords: Intervertebral disk displacement disk prolapse pregabalin
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 50
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine whether the use of oral pregabalin 150 mg as premedication reduces the amount and degree of postoperative pain.

Furthermore the purpose of this study is to determine whether the use of oral pregabalin 150 mg as premedication reduces anxiety prior to anaesthesia in these patients.

Detailed description:
The mechanism of development of postoperative pain is complex. Central and peripheral sensitization are playing an important role and this can lead to postoperative hypersensitization. Several studies have shown, that gabapentin can be effective to reduce sensitization and postoperative pain. Pregabalin (S-aminomethyl-5-methylhexaninacid) is a further development of gabapentin. Pregabalin has a fewer side-effects compared with gabapentin.

The purpose of this study is to compare the analgetic and anxiolytic effect of pregabalin and placebo used as premedication.

The hypothesis is that a single-dose pregabalin (150 mg postoperatively (p.o.)) gives significant better anxiolysis and analgesia than placebo.

The study is including patients undergoing surgery of the vertebral columna.

Arms:
arm 1: 150 mg Pregabalin per orally about one hour before surgery arm 2: One capsule of saccharose (placebo) was administered orally about one hour before surgery.

Interventions: intervention 1: pregabalin intervention 2: Placebo intervention 3: morphine
Intervention descriptions: intervention 1: capsule 150 mg x 1 per orally one hour before surgery intervention 2: One capsule of saccharose (placebo) was administered about one hour before surgery intervention 3: All patients were equipped with a PCA (patient controlled analgesia) for 24 hours after surgery. The sum of morphine used was registered (milligram).

Protocol document: