Conditions: Major Depressive Disorder
Keywords: Depression Major Depressive Disorder Escitalopram
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 877
Healthy volunteers: no

Brief summary:
This is a short-term study to evaluate the efficacy, safety, and tolerability of escitalopram in adult patients (18 to 65 years of age) with moderate to severe depression. Patients completing the study may be eligible to enter a long-term open-label extension study with escitalopram.

Detailed description:

Arms:
arm 1: Escitalopram low dose arm 2: Escitalopram high dose arm 3: Placebo

Interventions: intervention 1: Escitalopram intervention 2: Placebo intervention 3: Escitalopram
Intervention descriptions: intervention 1: Escitalopram low dose, oral administration, once daily dosing for 8 weeks. intervention 2: Placebo, oral administration, once daily dosing for 8 weeks intervention 3: Escitalopram high dose, oral administration, once daily dosing for 8 weeks

Protocol document: