Conditions: Methamphetamine Dependence
Keywords: Methamphetamine Dependence
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 45
Healthy volunteers: no

Brief summary:
The goal of the proposed study is to evaluate the efficacy and safety of N-Acetyl Cysteine (NAC) in combination with naltrexone in methamphetamine dependence.

Detailed description:
Forty subjects with DSM-IV methamphetamine dependence will receive 8 weeks of double-blind combination medication (NAC plus naltrexone) or placebo. The hypothesis to be tested is that NAC plus naltrexone will be effective and well tolerated in patients with methamphetamine dependence compared to placebo. The proposed study will provide needed data on the treatment of a public health crisis that currently lacks a clearly effective treatment.

Arms:
arm 1: Naltrexone tablets

N-Acetyl Cysteine: 600mg tablets, daily arm 2: Inactive placebo ("sugar pill")

Interventions: intervention 1: Naltrexone plus N-Acetyl Cysteine intervention 2: Placebo
Intervention descriptions: intervention 1: daily intervention 2: daily

Protocol document: