Conditions: GERD
Keywords: Gastroesophageal Reflux Disease Acid Reflux
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 3029
Healthy volunteers: no

Brief summary:
To compare the efficacy of three different long-term treatment strategies of reflux disease in primary care setting.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None arm 4: None arm 5: None

Interventions: intervention 1: esomeprazole (Nexium®) intervention 2: Xolaam®
Intervention descriptions: intervention 1: This randomized study was conducted on parallel groups and included two phases:

* One initial phase during when the patients received once daily, either esomeprazole 20 mg or esomeprazole 40 mg, depending on the investigator's decision
* One maintenance treatment phase, patients were randomized to one of the following three groups, either esomeprazole 20 mg once daily, or esomeprazole 20 mg on demand or antacid treatment as needed intervention 2: This randomized study was conducted on parallel groups and included two phases:

* One initial phase during when the patients received once daily, either esomeprazole 20 mg or esomeprazole 40 mg, depending on the investigator's decision
* One maintenance treatment phase, patients were randomized to one of the following three groups, either esomeprazole 20 mg once daily, or esomeprazole 20 mg on demand or antacid treatment as needed

Protocol document: