Conditions: Healthy
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 41
Healthy volunteers: yes

Brief summary:
To assess the effects of lanthanum carbonate (FOSRENOL) or sevelamer carbonate (RENVELA) on the pharmacokinetics of oral calcitriol (ROCALTROL)

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None

Interventions: intervention 1: Calcitriol intervention 2: Lanthanum carbonate + Calcitriol intervention 3: Sevelamer carbonate + Calcitriol
Intervention descriptions: intervention 1: Calcitriol (1.0 microgram) single dose at lunch administered on Day 1 of the study period. intervention 2: Lanthanum carbonate (1000 mg three times daily with meals for one day) + calcitriol (1.0 microgram) single dose at lunch administered on Day 1 of the study period. intervention 3: Sevelamer carbonate (2400 mg three times daily with meals for one day) + calcitriol (1.0 microgram) single dose at lunch administered on Day 1 of the study period.

Protocol document: