Conditions: Nausea
Allocation: RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 171
Healthy volunteers: no

Brief summary:
The purpose of this study is to compare the effectiveness of ondansetron, metoclopramide, and promethazine for the treatment of nausea in the adult emergency department population.

We hypothesize that a single intravenous dose of ondansetron is more effective in reducing nausea than a single IV dose of metoclopramide, promethazine or normal saline placebo in undifferentiated adult emergency department patients.

Detailed description:

Arms:
arm 1: Ondansetron 4 mg intravenous administration arm 2: Metoclopramide 10 mg intravenous administration arm 3: Promethazine 10 mg intravenous administration arm 4: Volume-matched saline placebo

Interventions: intervention 1: Ondansetron intervention 2: Metoclopramide intervention 3: Promethazine intervention 4: Normal Saline
Intervention descriptions: intervention 1: 4 mg intravenous dose administered over 2 minutes through a peripheral intravenous catheter intervention 2: 10 mg intravenous dose administered over 2 minutes through a peripheral intravenous catheter intervention 3: 12.5 mg intravenous dose administered over 2 minutes through a peripheral intravenous catheter intervention 4: Volume matched isotonic sodium chloride solution dose administered over 2 minutes through a peripheral intravenous catheter

Protocol document: