Conditions: Alzheimer's Disease
Keywords: Alzheimer's disease Cognition SB-742457
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 576
Healthy volunteers: no

Brief summary:
The study is designed to investigate the efficacy, safety and tolerability of SB-742457 versus placebo in subjects with mild-to-moderate Alzheimer's disease. SB-742457 is an experimental treatment which increases the levels of certain chemicals in the brain that are often decreased in patients with Alzheimer's disease.

Detailed description:

Arms:
arm 1: SB-742457 - 15mg arm 2: None arm 3: SB-742457 - 35mg arm 4: None

Interventions: intervention 1: SB-742457 intervention 2: Donepezil intervention 3: Placebo
Intervention descriptions: intervention 1: investigational drug intervention 2: comparator intervention 3: comparator

Protocol document: