Conditions: Neoplasm
Keywords: VGEF inhibitor Anti angiogenesis Advanced Solid Tumors
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 46
Healthy volunteers: no

Brief summary:
This study will test a new cancer medication to determine if this medication will block blood supply to a tumor and decrease growth of a tumor. This study will also define the safety profile and define the safest dose of this new medication for people who have cancer.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None arm 4: None arm 5: None arm 6: None arm 7: None arm 8: None arm 9: None arm 10: None

Interventions: intervention 1: PF-00337210 intervention 2: PF-00337210 intervention 3: PF-00337210 intervention 4: PF-00337210 intervention 5: PF-00337210 intervention 6: PF-00337210 intervention 7: PF-00337210 intervention 8: PF-00337210 intervention 9: PF-00337210 intervention 10: PF-00337210
Intervention descriptions: intervention 1: 0.67mg Capsule Once Daily (Accelerated Dose Escalation) Continuous intervention 2: 1mg Capsule Once Daily (Dose Escalation) Continuous intervention 3: 2mg Capsule Once Daily (Dose Escalation) Continuous intervention 4: 4mg Capsule Once Daily (Dose Escalation) Continuous intervention 5: 6mg Capsule Once Daily (Dose Escalation) Continuous intervention 6: 9mg Capsule Once Daily (Dose Escalation) Continuous intervention 7: 8mg Capsule Once Daily (Dose Escalation) Continuous intervention 8: 4mg Capsule Twice Daily (Dose Escalation) Continuous intervention 9: 6mg Capsule Twice Daily (Dose Escalation) Continuous intervention 10: 6mg Capsule Twice Daily (Dose Expansion) Continuous

Protocol document: