Conditions: Chemotherapy-induced Nausea and Vomiting (CINV)
Keywords: CINV
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 421
Healthy volunteers: no

Brief summary:
This study will demonstrate and confirm the efficacy and safety of MK0869 for the treatment of chemotherapy-induced nausea and vomiting in Chinese patients.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: aprepitant intervention 2: Comparator: Placebo to aprepitant intervention 3: dexamethasone intervention 4: granisetron intervention 5: dexamethasone
Intervention descriptions: intervention 1: Day 1: Oral aprepitant 125 mg prior to administration of cisplatin; Days 2 and 3: Oral aprepitant 80 mg intervention 2: Day 1: Placebo to oral aprepitant 125 mg prior to administration of cisplatin; Days 2 and 3: Placebo to oral aprepitant 80 mg intervention 3: Day 1: Oral dexamethasone 10.5 mg prior to administration of cisplatin; Days 2, 3, and 4: Oral dexamethasone 7.5 mg intervention 4: Day 1: IV granisetron 3 mg prior to administration of cisplatin intervention 5: Day 1: oral dexamethasone 6 mg prior to the administration of cisplatin; Days 2 and 3: oral dexamethasone 3.75 mg

Protocol document: