Conditions: Obesity Insulin Resistance
Keywords: obesity
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 6
Healthy volunteers: yes

Brief summary:
The purpose of this study is to learn more about how insulin resistance (inability to process glucose correctly resulting in mildly elevated glucose levels) affects the hormone ghrelin.

Detailed description:
Insulin resistance suppresses fasting ghrelin levels and impairs postprandial ghrelin suppression. Improved insulin sensitivity with a thiazolidinedione will raise ghrelin levels, enhance meal-related suppression, but not change the ratio of total to active ghrelin or result in an alteration of ghrelin structure.

Arms:
arm 1: Treatment with placebo for 3 months before spectroscopy, hyperinsulinemic-euglycemic clamp, control diet, blood sampling. arm 2: Treatment with pioglitazone for 3 months before hyperinsulinemic-euglycemic clamp, control diet with blood sampling and spectroscopy.

Interventions: intervention 1: placebo intervention 2: pioglitazone
Intervention descriptions: intervention 1: treatment with placebo for 3 months intervention 2: treatment with 30mg daily for two weeks then 45mg every day with pioglitazone for three months

Protocol document: