Conditions: Edema, Cardiac
Keywords: Cardiac edema OPC-41061 Vasopressin antagonist
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 110
Healthy volunteers: no

Brief summary:
To evaluate the efficacy and safety of 7-day repeated oral administration of OPC-41061 15 mg or placebo in congestive heart failure (CHF) patients with extracellular volume expansion despite the use of a conventional diuretic.

Detailed description:

Arms:
arm 1: 0mg arm 2: 15mg OPC-41061

Interventions: intervention 1: OPC-41061(Tolvaptan)
Intervention descriptions: intervention 1: 0, 15mg of OPC-41061 per day for 7days p.o. administration

Protocol document: