Conditions: Brain Edema Brain Tumor
Keywords: peritumoral brain edema edema malignant brain tumor astrocytoma brain tumor dexamethasone Decadron
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 200
Healthy volunteers: no

Brief summary:
The purpose of this study is to compare the safety and efficacy of XERECEPT® to dexamethasone (Decadron) a common treatment for symptoms of brain swelling (edema). This study is specifically aimed at patients who require chronic high doses of dexamethasone to manage symptoms.

Detailed description:
XERECEPT® is not a potential treatment for cancer, but may reduce the edema associated with tumors and as a result, decrease neurological symptoms.

Arms:
arm 1: Patients will take hCRF (XERECEPT) 2mg/day and open label-dexamethasone they are currently taking. arm 2: Patient will receive placebo hCRF and any open-label dexamethasone that they are currently taking

Interventions: intervention 1: hCRF intervention 2: placebo hCRF
Intervention descriptions: intervention 1: hCRF ; open-label dexamethasone that the patient is currently taking intervention 2: placebo hCRF 2mg/day and open-label dexamethasone that they are taking

Protocol document: