Conditions: Prostatic Neoplasms Metastases, Neoplasm
Keywords: prostate cancer Metastatic prostate cancer bone metastases
Enrollment: 22
Healthy volunteers: no

Brief summary:
The primary purpose of this study is to determine the safest dose of ZD4054 (Zibotentan)in men with prostate cancer

Detailed description:

Arms:
arm 1: 1 x 10 mg oral tablets once daily arm 2: 1 x 10 mg + 2 x 2.5 mg oral tablets once daily arm 3: 2 x 10 mg + 1 x 2.5 mg oral tablets once daily

Interventions: intervention 1: ZD4054 10 mg intervention 2: ZD4054 15 mg intervention 3: ZD4054 22.5 mg
Intervention descriptions: intervention 1: 1 x 10 mg oral tablets once daily intervention 2: 1 x 10 mg + 2 x 2.5 mg oral tablets once daily intervention 3: 2 x 10 mg + 2 x 2.5 mg oral tablets once daily

Protocol document: