Conditions: Hypertension
Keywords: Systolic hypertension hypertension aliskiren blood pressure ramipril HTN
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 901
Healthy volunteers: no

Brief summary:
Evaluate the systolic blood pressure lowering effect of aliskiren 150mg and 300mg compared to ramipril 5mg and 10mg in elderly patients with essential systolic hypertension.

Detailed description:

Arms:
arm 1: Aliskiren 150 mg; aliskiren 300 mg; aliskiren 300mg + hydrochlorothiazide 12.5 mg; aliskiren 300 mg + hydrochlorothiazide 25 mg; aliskiren 300 mg + hydrochlorothiazide 25 mg + amlodipine 5 mg; aliskiren 300 mg + hydrochlorothiazide 25 mg + amlodipine 10 mg arm 2: Ramipril 5 mg; Ramipril 10 mg; Ramipril 10 mg + hydrochlorothiazide 12.5 mg; Ramipril 10 mg + hydrochlorothiazide 25 mg; Ramipril 10 mg + hydrochlorothiazide 25 mg + amlodipine 5 mg; Ramipril 10 mg + hydrochlorothiazide 25 mg + amlodipine 10mg

Interventions: intervention 1: Aliskiren intervention 2: Ramipril intervention 3: Hydrochlorothiazide intervention 4: Amlodipine
Intervention descriptions: intervention 1: Aliskiren 150 mg and 300 mg tablets taken orally, once a day in the morning intervention 2: Ramipril 5 mg and 10 mg capsules taken orally, once a day in the morning intervention 3: Hydrochlorothiazide 12.5 or 25 mg capsules taken orally, once a day in the morning intervention 4: Amlodipine 5 mg or 10 mg tablets taken orally, once a day in the morning

Protocol document: