Conditions: Opioid-Related Disorders Substance-Related Disorders
Keywords: Opiate Opioid Abuse Liability Abuse Potential
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 27
Healthy volunteers: yes

Brief summary:
The purpose of this study is to examine the abuse liability of oxycodone in individuals with, and without, a history of prescription opioid abuse.

Detailed description:
Prescription opioid abuse is becoming an increasingly widespread and serious public health concern. The 2001 National Household Survey on Drug Abuse report revealed that the number of first-time users of prescription opioid medications for non-medical reasons reached 2 million in the year 2000, a number that has quintupled since 1984. Despite this trend, little experimental research has been directed towards understanding who may be abusing these medications, and under what conditions. The study will examine the reinforcing, subjective, performance, and physiological effects of oxycodone. Because it is not clear who is abusing prescription opioids, the medication effects will be compared in drug abusers and non-drug abusers.

Arms:
arm 1: Recreational users of prescription opioids. Participants in this arm received the 3 interventions (0, 15, and 30 mg oxycodone) at random. arm 2: Participants with a history of prescription opioid use, but who did not abuse them. Participants in this arm received the 3 interventions (0, 15, and 30 mg) at random.

Interventions: intervention 1: oxycodone 15 mg intervention 2: oxycodone 30 mg intervention 3: Placebo 0 mg
Intervention descriptions: intervention 1: 15 mg/70 kg oxycodone administered once per day, orally. intervention 2: 30 mg/70 kg oxycodone administered once per day, orally. intervention 3: 0 mg placebo dose administered once a day, orally.

Protocol document: