Conditions: HIV-1 Infection HIV Infections
Keywords: Treatment experienced
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 18
Healthy volunteers: no

Brief summary:
An open-label, 3-period, fixed-sequence study in a panel of 18 HIV-infected patients on MK0518 as part of a stable treatment regimen for HIV.

Detailed description:

Arms:
arm 1: MK0518 arm 2: famotidine + MK0518 arm 3: omeprazole + MK0518

Interventions: intervention 1: MK0518 (Raltegravir) intervention 2: famotidine intervention 3: omeprazole
Intervention descriptions: intervention 1: 400 mg oral tablet of MK0518 once every 12 hours. Period 1 duration is one day, Period 2 duration is one day, Period 3 duration is five days. intervention 2: Single 20 mg famotidine oral tablet taken 2 hours prior to administration of AM dose of MK0518 intervention 3: 20 mg oral tablet of omeprazole, once daily for 5 days

Protocol document: