Conditions: HIV Infection
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 400
Healthy volunteers: yes

Brief summary:
The purpose of this study is to examine safety and tolerability of daily tenofovir use in HIV-uninfected men.

Detailed description:
This study will assess the clinical and behavioral safety and tolerability of oral daily TDF use as pre-exposure prophylaxis (PrEP) to prevent HIV infection in uninfected men.

Arms:
arm 1: participants in this arm start study product immediately upon enrollment arm 2: participants in this arm start study product immediately upon enrollment arm 3: persons in this arm start study product 9 months after enrollment arm 4: participants in this arm start study product nine months after enrollment

Interventions: intervention 1: tenofovir disoproxil fumarate intervention 2: placebo
Intervention descriptions: intervention 1: study product taken daily intervention 2: study product taken daily

Protocol document: