Conditions: Neuropathic Pain
Keywords: eslicarbazepine acetate zebinix metformin
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 20
Healthy volunteers: yes

Brief summary:
The primary objective was to investigate whether multiple-dose administration of eslicarbazepine acetate affects the pharmacokinetics of metformin.

Detailed description:

Arms:
arm 1: Eslicarbazepine acetate + Metformin period followed by washout period followed by Metformin period arm 2: Metformin period followed by washout period followed by Eslicarbazepine acetate + Metformin period

Interventions: intervention 1: Metformin intervention 2: Eslicarbazepine acetate
Intervention descriptions: intervention 1: 850 mg metformin hydrochloride, once as oral single-dose and once after pre-treatment with once-daily dose of ESL 1200 mg for 6 days intervention 2: None

Protocol document: