Conditions: Healthy Volunteers
Keywords: Healthy subjects Opioid Transdermal
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 132
Healthy volunteers: yes

Brief summary:
The purpose of this study is to examine the effect of buprenorphine on QT interval corrected for heart rate (QTc) in healthy subjects.

Detailed description:
Drugs in this opioid class have been associated with prolonging QT interval/QT interval corrected for heart rate (QTc).

Arms:
arm 1: Buprenorphine transdermal patches 5, 10, 20, and 2 \* 20 mcg/h. arm 2: Matching placebo transdermal patches 5, 10, 20 and 2 \* 20. arm 3: Moxifloxacin hydrochloride 400 mg tablets

Interventions: intervention 1: Buprenorphine transdermal patch intervention 2: Matching placebo transdermal patch intervention 3: Avelox (moxifloxacin hydrochloride) tablet
Intervention descriptions: intervention 1: Buprenorphine transdermal patch 5, 10, 20, and 2 \* 20 mcg/h. intervention 2: Placebo transdermal patch to match BTDS 5, 10, 20, and 2 \* 20. intervention 3: Moxifloxacin 400 mg tablet; 1 tablet taken orally on days 6 and 13

Protocol document: