Conditions: Type 2 Diabetes
Keywords: insulin aspart 30 insulin aspart 70 insulin aspart postprandial glucose and lipid metabolism consecutive mixed meals
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 20
Healthy volunteers: no

Brief summary:
The aim of the study is to investigate meal-related treatment with either premixed Insulin Aspart 30, Aspart 70 and Aspart with regard to postprandial glucose, triglyceride and free fatty acids excursions after a standard breakfast and lunch.

Detailed description:
Whereas the effects of each of the established types of insulin (remixed Insulin Aspart 30, Aspart 70 and Aspart) have been shown before, their specific glucose and lipid lowering capacities have so far not been investigated in a simulated physiological situation.

Arms:
arm 1: 35% of their usual total daily insulin dose before the standardized breakfast and 25% prior to lunch arm 2: 35% of their usual total daily insulin dose before the standardized breakfast and 25% prior to lunch arm 3: 35% of their usual total daily insulin dose before the standardized breakfast and 25% prior to lunch

Interventions: intervention 1: Insulin Aspart intervention 2: Insulin Aspart 30 intervention 3: Insulin Aspart 70
Intervention descriptions: intervention 1: Patients received insulin aspart before breakfast and before lunch. intervention 2: Patients received biphasic insulin aspart 30 before breakfast and before lunch. intervention 3: Patients received biphasic insulin aspart 70 before breakfast and before lunch.

Protocol document: