Conditions: Migraine
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 108
Healthy volunteers: no

Brief summary:
This study will provide additional efficacy data for rizatriptan when used for an acute migraine attack in patients already taking topiramate for migraine prophylaxis.

Detailed description:

Arms:
arm 1: Treatment Sequence A: rizatriptan, rizatriptan, placebo arm 2: Sequence B: rizatriptan, placebo, rizatriptan arm 3: Sequence C: placebo, rizatriptan, rizatriptan

Interventions: intervention 1: rizatriptan benzoate intervention 2: Comparator: placebo
Intervention descriptions: intervention 1: rizatriptan 10 mg Orally Disintegrating Tablet (ODT) orally for a moderate or severe migraine attack intervention 2: Placebo to rizatriptan 10 mg ODT orally for a moderate or severe migraine attack

Protocol document: