Conditions: Hypertension, Pulmonary
Keywords: pulmonary hypertension & insulin resistance
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 2
Healthy volunteers: no

Brief summary:
The purpose of this study is to evaluate 1) the incidence of insulin resistance (a pre-diabetic state) in patients with pulmonary hypertension, and 2) test the utility of a validated PH therapy (Tracleer) versus Pioglitazone in the treatment of those patients found to have insulin resistance.

Detailed description:
The Effect of Bosentan and Pioglitazone on Insulin Resistance in Pulmonary Arterial Hypertension ,is a study evaluating the incidence of insulin resistance in patients with pulmonary hypertension and testing the utility of a validated PH therapy(Tracleer) versus Pioglitazone in the treatment of those patients found to have insulin resistance.Patients with PAH must be stable on therapy for at least 3 months are considered for enrollment in this study.With the exception of PAH, subjects must be free of major medical illnesses, including diabetes mellitus ,malignancy or significant hepatic or renal disease.

Arms:
arm 1: Bosentan 62.5 twice daily for 4 weeks, then 125 mg twice daily. arm 2: Pioglitazone 15 mg a day for 4 weeks then Pioglitazone 30 mg a day for the duration of the study.

Interventions: intervention 1: bosentan intervention 2: Pioglitazone
Intervention descriptions: intervention 1: Bosentan 62.5 mg BID for 4 weeks, then 125mg BID for duration of study. intervention 2: Pioglitazone 15 mg a day for 4 weeks then Pioglitazone 30 mg a day for the duration fo the study.

Protocol document: