Conditions: Metabolic Syndrome
Keywords: metabolic syndrome Volunteers recruited from the community
Allocation: RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 40
Healthy volunteers: yes

Brief summary:
To characterize features of metabolic syndrome in volunteers. To undertake a randomised trial to determine whether treatment with a statin improves muscle microvascular blood flow.

Detailed description:
To characterise features of the metabolic syndrome, including body fat, insulin sensitivity, and liver fat together with muscle micorvascular blood flow.

To undertake a randomised controlled trial of atorvastatin 40 mg. o.d for 6 months to determine whether any of the above measures change with treatment.

Arms:
arm 1: Active arm atorvastatin 40 mg. o.d. arm 2: Placebo arm dummy pill

Interventions: intervention 1: atorvastatin intervention 2: placebo
Intervention descriptions: intervention 1: 40 m.g. o.d. tablets for 6 months intervention 2: Placebo

Protocol document: