Conditions: Hyponatremia Acute Decompensated Heart Failure
Keywords: hyponatremia euvolemic hyponatremia hypervolemic hyponatremia acute decompensated heart failure conivaptan Vaprisol
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 9
Healthy volunteers: no

Brief summary:
This study will evaluate the safety and effectiveness of Conivaptan, a vasopressin antagonist, in the treatment of hyponatremic subjects having symptomatic acute decompensated heart failure (ADHF).

Detailed description:
Subjects will be recruited from the Emergency Department. It is expected that subjects will be treated according to the institution's accepted conventional therapy protocol for the treatment of ADHF. Therapy may also include the use of loop diuretics for the relief of pulmonary congestion and maintenance of adequate urine output.

Arms:
arm 1: Matching loading dose and continuous intravenous infusion for 48 hours arm 2: 20mg loading dose followed by a 20mg/ day continuous intravenous infusion for 48 hours

Interventions: intervention 1: conivaptan intervention 2: placebo
Intervention descriptions: intervention 1: Premix bag intervention 2: Premix bag

Protocol document: