Conditions: Alzheimer's Disease
Keywords: phase 1 Alzheimer's disease donepezil
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 15
Healthy volunteers: no

Brief summary:
The purpose of the study is to evaluate the safety of PF-04447943 when given in combination with donepezil in subjects who have Alzheimer's Disease. The study will also evaluate the absorption and distribution of both PF-04447943 and donepezil.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: PF-04447943 intervention 2: Placebo
Intervention descriptions: intervention 1: 25 mg of PF-04447943 orally every 12 hours for 7 days intervention 2: 25 mg matching placebo to PF-04447943 orally every 12 hours for 7 days

Protocol document: