Conditions: Irritable Bowel Syndrome
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 70
Healthy volunteers: no

Brief summary:
This study is being done to see if St. John's wort helps people with irritable bowel syndrome, otherwise known as "IBS". St. John's wort is a herbal supplement derived from the St. John's wort plant. It has been shown to be helpful in several medical conditions such as depression as well as other pain syndromes.

Detailed description:
Eligibility criteria:

1. Established diagnosis of IBS
2. 18-70 years of age

4\) U.S. resident 5) English-speaking (able to provide consent and complete questionnaires) 6) Able to participate in all aspects of the study

You will be asked to do the following:

* Undergo a screening interview and physical examination
* Take a urine pregnancy test (if applicable)
* Take a study pill twice daily for 12 weeks(3 months)
* Complete daily symptom diaries and bi-weekly questionnaires for 12 weeks.
* Complete a questionnaire at 6 months after the active phase of the study is over.

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: St. John's wort intervention 2: Placebo
Intervention descriptions: intervention 1: Dosage form: Tablet (450 mg) Dose: 450 mg twice a day, placebo twice a day intervention 2: Dosage form: Tablet (450 mg) Dose: 450 mg twice a day, placebo twice a day

Protocol document: