Conditions: Headache, Tension-Type
Keywords: caffeine paracetamol tension headache
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 66
Healthy volunteers: no

Brief summary:
This study will compare a fast-absorbing paracetamol plus caffeine formula with placebo and an over-the-counter dose of paracetamol and ibuprofen to treat episodic tension headache.

Detailed description:

Arms:
arm 1: Placebo arm 2: paracetamol marketed forumulation arm 3: ibuprofen marketed formulation arm 4: experimental paracetamol + caffeine formulation

Interventions: intervention 1: Placebo intervention 2: Experimental paracetamol + caffeine formulation intervention 3: ibuprofen marketed formulation intervention 4: Paracetamol marketed formulation
Intervention descriptions: intervention 1: Placebo intervention 2: experimental paracetamol + caffeine formulation intervention 3: ibuprofen marketed formulation intervention 4: Paracetamol marketed formulation

Protocol document: