Conditions: Osteoarthritis of the Knee
Keywords: delta opioid receptor agonist osteoarthritis pain
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 408
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine the efficacy of ADL5859 versus placebo and ADL5747 versus placebo in relieving pain in participants with osteoarthritis of the knee.

Detailed description:

Arms:
arm 1: One 50-milligrams (mg) ADL5859 capsule, one 100-mg ADL5859 capsule, and 2 placebo capsules administered orally twice daily (BID) for 14 days arm 2: One 150-mg ADL5747 capsule and 3 placebo capsules administered orally BID for 14 days arm 3: One 10-mg Oxycodone controlled release (CR) capsule and 3 placebo capsules administered orally BID Days 1 through 4

One 20-mg Oxycodone CR capsule and 3 placebo capsules administered orally BID Days 5 through 14 arm 4: Four placebo capsules administered orally BID for 14 days

Interventions: intervention 1: ADL5859 intervention 2: ADL5747 intervention 3: Oxycodone CR intervention 4: Placebo
Intervention descriptions: intervention 1: None intervention 2: None intervention 3: None intervention 4: None

Protocol document: