Conditions: Heart Failure
Keywords: Heart failure Inflammation Interleukin-1 Cardiopulmonary exercise
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 11
Healthy volunteers: no

Brief summary:
This is an open-label, non-randomized, pilot-study to evaluate the effect of Interleukin-1 blockade on exercise capacity in patients with heart failure. Subjects will undergo cardiopulmonary exercise testing at baseline and after 2-weeks treatment with anakinra (recombinant human Interleukin-1 receptor antagonist).

Detailed description:

Arms:
arm 1: None

Interventions: intervention 1: Anakinra
Intervention descriptions: intervention 1: Anakinra 100 mg subcutaneous injection daily

Protocol document: