Conditions: Coronary Artery Disease Chest Pain
Keywords: Platelets, platelet aggregation inhibitors
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 27
Healthy volunteers: no

Brief summary:
This study will explore the effect of clopidogrel on coated-platelets in patients who are given a loading dose before diagnostic catheterization or percutaneous coronary intervention. We hypothesis that clopidogrel will reduce the percentage of platelets that are coated and therefore more hypercoagulable.

Detailed description:
Platelet activity will be determined by light transmission aggregometry at baseline, after a 300 mg dose of clopidogrel and after the catheterization and/or angioplasty procedure. The change in the percentage of platelets that are coated platelets will be determined.

Arms:

Interventions: intervention 1: Clopidogrel
Intervention descriptions: intervention 1: All subjects will receive a 300 mg loading dose

Protocol document: