Conditions: Vitrectomy
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 125
Healthy volunteers: no

Brief summary:
A multicenter study to compare multiple doses of intravitreal microplasmin in patients undergoing surgical vitrectomy.

Detailed description:

Arms:
arm 1: 25µg of ocriplasmin intravitreal injection arm 2: 75µg of ocriplasmin intravitreal injection arm 3: 125µg of ocriplasmin intravitreal injection arm 4: Intravitreal injection of placebo

Interventions: intervention 1: Ocriplasmin 25µg intervention 2: Ocriplasmin 75µg intervention 3: Ocriplasmin 125µg intervention 4: Placebo
Intervention descriptions: intervention 1: Intravitreal injection of 0.1 ml of ocriplasmin solution containing 25µg of ocriplasmin. intervention 2: Intravitreal injection of 0.1 ml of ocriplasmin solution containing 75µg of ocriplasmin. intervention 3: Intravitreal injection of 0.1 ml of ocriplasmin solution containing 125µg of ocriplasmin. intervention 4: Intravitreal injection of placebo

Protocol document: