Conditions: Rheumatoid Arthritis
Keywords: arthritis joint pain Methotrexate
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 227
Healthy volunteers: no

Brief summary:
This study will determine the efficacy, safety, and tolerability of denosumab (AMG 162) in the treatment of Rheumatoid Arthritis (RA).

Detailed description:

Arms:
arm 1: Participants received 180 mg denosumab by subcutaneous injection on Day 1 and at Month 6. arm 2: Participants received 60 mg denosumab by subcutaneous injection on Day 1 and at Month 6. arm 3: Participants received placebo subcutaneous injections on Day 1 and at Month 6.

Interventions: intervention 1: placebo intervention 2: denosumab
Intervention descriptions: intervention 1: placebo subcutaneous injection intervention 2: For subcutaneous injection

Protocol document: