Conditions: Type 2 Diabetes Mellitus
Keywords: diabetes exenatide once weekly Byetta Amylin Lilly Bydureon
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 254
Healthy volunteers: no

Brief summary:
This study will compare the effects of commercially manufactured exenatide once weekly and exenatide BID in subjects whose type 2 diabetes is managed with diet and exercise alone or with oral antidiabetic medications. The study will examine glycemic control (as measured by HbA1C), safety, and tolerability.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: exenatide once weekly intervention 2: exenatide twice daily
Intervention descriptions: intervention 1: subcutaneous injection, 2.0mg, once a week intervention 2: subcutaneous injection; 5mcg (4 weeks) and 10mcg (20 weeks); twice a day

Protocol document: