Conditions: Chronic Idiopathic Urticaria
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 314
Healthy volunteers: no

Brief summary:
This study will investigate the effectiveness of desloratadine at doses higher (10 mg and 20 mg) than currently approved (5 mg) for the treatment of chronic idiopathic urticaria. Subjects with chronic urticaria who are currently taking a second generation antihistamine will be treated with desloratadine (5, 10, or 20 mg) for 28 days.

Detailed description:

Arms:
arm 1: 5-mg Desloratadine once daily arm 2: 10-mg Desloratadine once daily arm 3: 20-mg Desloratadine once daily

Interventions: intervention 1: 5-mg Desloratadine intervention 2: 10-mg Desloratadine intervention 3: 20-mg Desloratadine
Intervention descriptions: intervention 1: 5-mg desloratadine tablets, once daily for four weeks. intervention 2: 10-mg desloratadine tablets, once daily for four weeks. intervention 3: 20-mg desloratadine tablets, once daily for four weeks.

Protocol document: