Conditions: Alcoholism
Keywords: baclofen alcoholism urge craving alcohol drinking biobehavioral mechanisms of baclofen in alcoholism
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 14
Healthy volunteers: no

Brief summary:
This pilot trial has the goal to demonstrate the feasibility of a study to test the effects of baclofen in a laboratory experiment using cue-reactivity and alcohol-self administration paradigms in non-treatment seeking alcohol-dependent subjects.

Detailed description:

Arms:
arm 1: Baclofen 10 mg three times a day (t.i.d.) for 8-10 days arm 2: Cyproheptadine 2 mg t.i.d. for 8-10 days

Interventions: intervention 1: Baclofen intervention 2: Cyproheptadine
Intervention descriptions: intervention 1: Baclofen 10mg t.i.d. intervention 2: 'active' placebo

Protocol document: