Conditions: Primary Sclerosing Cholangitis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 35
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine whether Vancomycin or Metronidazole is safe and beneficial in the treatment of Primary Sclerosing Cholangitis.

Detailed description:
In this protocol, we propose the assessment of potential beneficial effects of the antibiotics vancomycin and metronidazole on liver biochemistries, liver related symptoms and Mayo risk score in patients with PSC. The patients will be randomized into four groups of ten patients: one group will receive low dose vancomycin, one group will receive high dose vancomycin, one group will receive low dose metronidazole and one group will receive high dose metronidazole. Each group will be treated for three months.

Arms:
arm 1: The patients will be randomized into four groups of ten patients: one group will receive low dose vancomycin, one group will receive high dose vancomycin, one group will receive low dose metronidazole and one group will receive high dose metronidazole. arm 2: None arm 3: None arm 4: None

Interventions: intervention 1: Vancomycin intervention 2: Vancomycin intervention 3: Metronidazole intervention 4: Metronidazole intervention 5: Vancomycin
Intervention descriptions: intervention 1: Comparison of different doses of drug intervention 2: Comparison of different doses of drug intervention 3: Comparison of different doses of drug intervention 4: Comparison of different doses of drug intervention 5: Comparison of different drug doses

Protocol document: