Conditions: Cognition
Keywords: Anti-muscarinics Anti-cholinergics Cognition Solifenacin
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 26
Healthy volunteers: yes

Brief summary:
The purpose is to compare solifenacin and oxybutynin with an inactive tablet and assess any potential effects on mental ability.

Detailed description:
All subjects will receive each intervention during the course of the study. Subjects will complete a 21-day washout period between treatment periods and following last treatment period.

Arms:
arm 1: Participants received 21 days of treatment with 5 mg solifenacin, in tablet form once a day. arm 2: Participants received 21 days of treatment with 10 mg oxybutynin (1 x 5 mg twice daily) in capsule form. arm 3: Participants received 21 days of treatment with placebo.

Interventions: intervention 1: Solifenacin intervention 2: Oxybutynin intervention 3: Placebo
Intervention descriptions: intervention 1: tablet intervention 2: capsule intervention 3: tablet

Protocol document: