Conditions: Acute Asthma
Keywords: Asthma Acute asthma Pediatrics
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 16
Healthy volunteers: no

Brief summary:
Our overall objective is to model a pediatric Acute Asthma Clinical Decision Rule (ADR) for personalized medicine by identification of treatment-response phenotypes that are important determinants of outcome. The Specific Aim of this study is to determine the feasibility of this approach by enrolling a pilot cohort of 16 participants in this DBRCT of 4 different albuterol treatment regimens, 2 of which will use 10mg/hr and 2 of which will use 25mg/hr. Within these dosages there will be a pulsed-treatment regimen and a continuous regimen.

Detailed description:
The objective of this study is to determine the feasibility of this approach by enrolling a pilot cohort of 16 participants in this DBRCT of 4 different albuterol treatment regimens, 2 of which will use 10mg/hr and 2 of which will use 25mg/hr. Participants are randomized in randomly permuted blocks of four. Within these dosages there will be a pulsed-treatment regimen and a continuous regimen.

Arms:
arm 1: Active control arm, 10mg/hr continuous. arm 2: Experimental 10mg/hr pulsed albuterol regimen. arm 3: Experimental 25mg/hr continuous albuterol. arm 4: Experimental 25mg/hr pulsed albuterol

Interventions: intervention 1: Albuterol
Intervention descriptions: intervention 1: Nebulized albuterol

Protocol document: