Conditions: Psoriasis
Keywords: Psoriasis Topical corticosteroids Plaque psoriasis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 151
Healthy volunteers: no

Brief summary:
The objectives of this study are to evaluate the efficacy and safety of two dosing regimens of desoximetasone 0.05% and 0.25% topical sprays as compared to a vehicle spray in patients with moderate to severe plaque psoriasis.

Detailed description:

Arms:
arm 1: Desoximetasone topical spray 0.05% administered once daily to affected area arm 2: Desoximetasone topical spray 0.05% administered twice daily to affected area arm 3: Desoximetasone topical spray 0.25% administered once daily to affected area arm 4: Desoximetasone topical spray 0.25% administered twice daily to affected area arm 5: Vehicle administered to affected areas once daily arm 6: Vehicle administered to affected areas twice daily

Interventions: intervention 1: Desoximetasone 0.05% once daily intervention 2: Desoximetasone 0.05% twice daily intervention 3: Desoximetasone 0.25% once daily intervention 4: Desoximetasone 0.25% once daily intervention 5: Vehicle once daily intervention 6: Vehicle twice daily
Intervention descriptions: intervention 1: Desoximetasone topical spray 0.05% administered to affected area once daily for 28 days intervention 2: Desoximetasone topical spray 0.05% administered to affected area twice daily for 28 days intervention 3: Desoximetasone topical spray 0.25% administered to affected area once daily for 28 days intervention 4: Desoximetasone topical spray 0.25% administered to affected areas twice daily for 28 days intervention 5: Vehicle topical spray administered to affected areas once daily for 28 days intervention 6: Vehicle topical spray administered to affected areas twice daily for 28 days

Protocol document: