Conditions: Malaria Falciparum
Keywords: Malaria hearing co-artemether auditory Plasmodium falciparum marsh fever Plasmodium infections remittent fever paludism artemether artemisinins benflumetol lumefantrine
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 265

Brief summary:
To evaluate the potential effects of artemether- lumefantrine on the auditory function

Detailed description:

Arms:
arm 1: Artemether-lumefantrine (Coartem) tablets containing 20 mg artemether and 120 mg lumefantrine twice a day for 3 days, dosage dependent on body weight. arm 2: Atovaquone-proguanil (Malarone) tablets containing 250 mg atovaquone and 100 mg proguanil hydrochloride once daily for 3 days, dosage dependent on body weight. arm 3: Artesunate-mefloquine tablets containing 50 mg artesunate (Plasmotrim) and 250 mg mefloquine (Mephaquin). Artesunate 4 mg/kg/day (for 3 days) and mefloquine 25 mg/kg/day (days 2 and 3) total dose was given once daily dependent upon body weight.

Interventions: intervention 1: Artesunate-mefloquine intervention 2: Atovaquone-proguanil intervention 3: Artemether-lumefantrine
Intervention descriptions: intervention 1: None intervention 2: None intervention 3: None

Protocol document: