Conditions: Genital Herpes
Keywords: herpes simplex virus acyclovir HSV shedding women Africa
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 88
Healthy volunteers: yes

Brief summary:
To examine the time to healing of genital lesion and duration of herpes simplex virus (HSV) shedding from genetic ulcer disease (GUD) among 90 HIV-negative African women who have a history of GUD and are HSV-2 seropositive and HIV-1 seronegative randomized in a 2:1 ratio to receive episodic acyclovir 400mg orally three times daily or matching placebo three times daily for 5 days and who are followed for a total of 13 days.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: acyclovir intervention 2: matching placebo
Intervention descriptions: intervention 1: 400mg taken orally three times daily for 5 days intervention 2: matching placebo taken orally three times daily for 5 days.

Protocol document: