Conditions: Pulmonary Disease, Chronic Obstructive
Keywords: Bronchitis, Chronic; Emphysema
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 181
Healthy volunteers: no

Brief summary:
This study evaluated the effect of inhaled aclidinium bromide on exercise endurance and in reducing resting and dynamic lung hyperinflation in patients with moderate to severe COPD. It was 9 weeks in duration, consisting of; a 2-week run-in period, 6 weeks of double-blind treatment, and a 1-week follow-up phone call. All patients meeting the eligibility criteria were randomized to one of two treatment groups: aclidinium bromide or placebo.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Aclidinium Bromide intervention 2: Placebo
Intervention descriptions: intervention 1: Aclidinium Bromide, 200μg. Once daily oral inhalation. intervention 2: Dose matched placebo, once daily oral inhalation.

Protocol document: