Conditions: Type 2 Diabetes Mellitus
Keywords: Type 2 diabetes mellitus renal disease hypertension renal blood flow retinal blood flow aliskiren irbesartan captopril
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 45
Healthy volunteers: no

Brief summary:
The study objective was to assess the effect of single and multiple doses of aliskiren on renal plasma flow, glomerular filtration rate and to compare the effects of single and multiple doses of aliskiren versus captopril or irbesartan on renal blood flow, glomerular filtration rate, and retinal blood flow in patients with type 2 diabetes mellitus.

Detailed description:

Arms:
arm 1: On Day 1 participants received a single oral dose of 25 mg captopril. Starting on Day 2 participants received aliskiren 300 mg tablets orally once a day for 14 days. arm 2: On Day 1 participants received a single oral dose of 25 mg captopril. Starting on Day 2 participants received irbesartan 300 mg tablets orally once a day for 14 days.

Interventions: intervention 1: Aliskiren intervention 2: Irbesartan intervention 3: Captopril
Intervention descriptions: intervention 1: Aliskiren 300 mg tablets intervention 2: Irbesartan 300 mg tablets intervention 3: Captopril 25 mg tablet

Protocol document: