Conditions: Hypersensitivity
Keywords: Histamine H1 Antagonists Anti-Allergic Agents
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 36
Healthy volunteers: no

Brief summary:
This is a randomized, double-blind, double-dummy, placebo-controlled, parallel-group, single center study in subjects with positive histamine skin prick test and a positive RadioAllergoSorbent Test (RAST) (class \> 2) to one of the tested standardized allergenic extracts: tree pollen, cat dander, house dust mite, or a mixture of five grass pollens. Subjects will be randomized to desloratadine 5 mg once daily, levocetirizine 5mg once daily, or placebo once daily for 8 days of treatment followed by 11 days of skin testing after discontinuation of the antihistamine treatment phase. The duration of the suppressive effects of desloratadine on cutaneous allergen-induced wheal and flare responses after discontinuation of a one-week treatment will be established.

Detailed description:

Arms:
arm 1: Subject was instructed to take 1 tablet and 1 capsule, once daily from day one (visit 3) to day 8 (visit 4). arm 2: Subject was instructed to take 1 tablet and 1 capsule, once daily from day one (visit 3) to day 8 (visit 4). arm 3: Subject was instructed to take 1 tablet and 1 capsule, once daily from day one (visit 3) to day 8 (visit 4).

Interventions: intervention 1: desloratadine intervention 2: levocetirizine intervention 3: Desloratadine placebo tablet intervention 4: Levocetirizine placebo capsule
Intervention descriptions: intervention 1: 5 mg tablet once daily intervention 2: 5 mg capsule once daily intervention 3: once daily intervention 4: once daily

Protocol document: