Conditions: Arthritis, Gouty
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 402
Healthy volunteers: no

Brief summary:
This is a multicenter, double-blind, double-dummy, randomized, active-controlled study that will include an 8-day treatment period followed by a 1-week follow-up period in patients experiencing symptoms of an acute exacerbation of gouty arthritis.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None arm 4: None

Interventions: intervention 1: Indomethacin intervention 2: Celecoxib intervention 3: Celecoxib intervention 4: Celecoxib
Intervention descriptions: intervention 1: indomethacin 50 mg three times a day (TID) for 8 days. intervention 2: An initial dose of celecoxib 800 mg followed by a second dose of 400 mg 12 hours later on Day 1 (celecoxib 800/400 mg regimen) and continuing 400 mg two times a day (BID) for 7 days. intervention 3: An initial dose of celecoxib 400 mg followed by a second dose of 200 mg 12 hours later (celecoxib 400/200 mg regimen) and continuing 200 mg two times a day (BID) for 7 days. intervention 4: Celecoxib 50 mg two times a day (BID) for 8 days

Protocol document: