Conditions: Angina Pectoris
Keywords: angina pectoris chest pain heart rate
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 251
Healthy volunteers: no

Brief summary:
The purpose of this study is to evaluate the effects of Succinate Metoprolol(Betaloc ZOK®) (95 - 190 mg) on heart rate in the Stable angina patients.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Succinate Metoprolol (Betaloc ZOK®) intervention 2: Succinate Metoprolol (Betaloc ZOK®)
Intervention descriptions: intervention 1: treatment with 47.5mg for two weeks, if tolerated and without Systolic blood pressure\<100mmHg and heart rate \<45 bpm according to 12-lead Electrocardiogram at Week 3, the dosage will be titrated to 95mg and last for another 6 weeks intervention 2: Treatment with 95mg for two weeks, and if tolerated and without bradycardia symptoms presented, Systolic blood pressure\<100mmHg and heart rate \<45 bpm according to 12-lead Electrocardiogram at Week 3，the dosage will be force titrated to 190mg and last for another 6 weeks

Protocol document: