Conditions: Type 2 Diabetes Mellitus
Keywords: Amylin Lilly exenatide once weekly Byetta Januvia sitagliptin thiazolidinedione
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 820
Healthy volunteers: no

Brief summary:
This study will compare the effects of 2.0 mg exenatide once weekly injection as monotherapy to 3 active comparators(metformin, dipeptidyl peptidase-4 inhibitor, and thiazolidinedione) in drug naive patients with type 2 diabetes treated with diet and exercise.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None arm 4: None

Interventions: intervention 1: exenatide once weekly intervention 2: metformin intervention 3: sitagliptin intervention 4: pioglitazone
Intervention descriptions: intervention 1: subcutaneous injection, 2mg, once weekly plus placebo oral once daily intervention 2: oral, 1000-2500mg, daily plus placebo once weekly subcutaneous injection intervention 3: oral, 100 mg, daily plus placebo once weekly subcutaneous injection intervention 4: oral, 30-45mg, daily plus placebo once weekly subcutaneous injection

Protocol document: