Conditions: Liver Diseases
Keywords: Non alcoholic steatohepatitis Steatohepatitis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 247
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine if therapy with pioglitazone or vitamin E will lead to an improvement in liver histology in non-diabetic adult patients with non-alcoholic steatohepatitis (NASH).

Detailed description:
The purpose of this study is to determine if therapy with pioglitazone or vitamin E will lead to an improvement in liver histology in non-diabetic adult patients with non-alcoholic steatohepatitis (NASH).

Arms:
arm 1: Pioglitazone arm 2: Vitamin E arm 3: Placebo Pioglitazone or Placebo Vitamin E

Interventions: intervention 1: Pioglitazone intervention 2: Vitamin E intervention 3: Matching placebo
Intervention descriptions: intervention 1: 30 mg daily intervention 2: 800 IU daily intervention 3: Daily

Protocol document: