Conditions: Hypertension; Hypertrophy, Left Ventricular
Keywords: Left ventricular hypertrophy, hypertension, valsartan, amlodipine
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 90
Healthy volunteers: no

Brief summary:
This study will evaluate the safety and efficacy of amlodipine plus valsartan in patients with hypertension and left ventricular hypertrophy

Detailed description:

Arms:
arm 1: Participants received 160 mg Valsartan and 5 mg amlodipine orally once a day for 52 weeks. If blood pressure was not normalized at week 4, treatment was uptitrated to valsartan/amlodipine 160/10 mg. Participants with still uncontrolled hypertension could receive add-on antihypertensive medication. arm 2: Participants received 100 mg losartan and 12.5 mg Hydrochlorothiazide (HCT) orally once a day for 52 weeks. If blood pressure was not normalized at week 4, treatment was uptitrated to losartan/HCT 100/25 mg, respectively, until end of study. Participants with still uncontrolled hypertension could receive add-on antihypertensive medication.

Interventions: intervention 1: Valsartan intervention 2: Amlodipine intervention 3: Hydrochlorothiazide intervention 4: Losartan
Intervention descriptions: intervention 1: 160 mg film coated tablets taken orally once daily in the morning. intervention 2: 5 mg or 10 mg tablets taken orally once daily in the morning. intervention 3: 12.5 mg or 25 mg tablets taken orally once daily in the morning. intervention 4: 100 mg tablets taken orally once daily in the morning.

Protocol document: