Conditions: Type 2 Diabetes Mellitus
Keywords: Glargine Type 2 diabetes Basal insulin
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 27
Healthy volunteers: no

Brief summary:
To compare the efficacy and safety of once-nightly insulin glargine versus twice-daily NPH insulin in ethnic minority type 2 diabetic patients inadequately treated with once-nightly NPH insulin alone.

Detailed description:
Insulin glargine has a longer action than compared to NPH insulin, but whether this results in improved control when compared to twice-daily NPH insulin is not known when used in low-income ethnic minority patients. This study investigates whether insulin glargine may be more or less effective and safe than twice-daily NPH insulin in this population.

Arms:
arm 1: Insulin glargine injected at bedtime arm 2: NPH insulin injected twice-daily, before breakfast and at bedtime

Interventions: intervention 1: Insulin glargine at bedtime instead of NPH intervention 2: NPH twice-daily
Intervention descriptions: intervention 1: Insulin glargine at bedtime substituting for NPH insulin at bedtime intervention 2: Addition of morning NPH to bedtime NPH

Protocol document: