Conditions: Inflammation
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 108
Healthy volunteers: yes

Brief summary:
The purpose of the study is to test whether atorvastatin (also known as Lipitor) has anti-inflammatory effects in people with no known heart disease or high cholesterol. We also are investigating whether or not genetic differences between people plays a role in the drug response.

Detailed description:
All subjects received 16 weeks of Atorvastatin after a two week run in. Key dependent variables were the 16 week value minus the baseline value (post run-in). Last observation carried forward was used for missing values. The key comparisons are for two groups OATP1B1 reduced carriers and on-carriers and their association with Cytokines and Lipids. Secondarily, we were interested in changes over the 16 weeks for the pooled sample, irrespective of genetics.

Arms:
arm 1: 80mg of atorvastatin given once daily for 16 weeks

Interventions: intervention 1: Atorvastatin
Intervention descriptions: intervention 1: atorvastatin 80mg tablets given by mouth once daily for 16 weeks with follow-up visits every 4 weeks

Protocol document: