Conditions: Diabetes Diabetes Mellitus, Type 2
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 49
Healthy volunteers: no

Brief summary:
This trial is conducted in the United States of America (USA). The purpose of the trial is to assess the effect of liraglutide on forearm blood flow in subjects with type 2 diabetes who are on diet and lifestyle changes or treated with metformin alone.

Detailed description:

Arms:
arm 1: Liraglutide 1.8 mg administered subcutaneously, once-daily, weeks 0-12 (100 uL/day, week 1; 200 uL/day, week 2; 300 uL/day, week 3-12) arm 2: Placebo administered subcutaneously, once-daily, weeks 0-12 (100 uL/day, week 1; 200 uL/day, week 2; 300 uL/day, week 3-12) arm 3: Glimepiride 4 mg administered orally, once-daily, open-label, weeks 0-12

Interventions: intervention 1: liraglutide intervention 2: placebo intervention 3: glimepiride
Intervention descriptions: intervention 1: Stepwise dose increase, s.c. (under the skin) injection, once daily intervention 2: Liraglutide placebo, stepwise dose increase, s.c. (under the skin) injection, once daily intervention 3: Tablets, 1 - 4 mg daily

Protocol document: