Conditions: Dental Caries
Keywords: Caries detection/diagnosis/prevention Preventive Dentistry Casien Phosphopeptide Remineralization Clinical trial
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 296
Healthy volunteers: yes

Brief summary:
The purpose of this study is to determine if adding daily application of CPP-ACP containing paste for one year is superior to regular fluoride tooth brushing in preventing dental caries in high caries risk Thai preschool children.

Detailed description:
The 6th National Oral Health Survey in Thailand 2006-2007 reported that 3-year-old children who resided in central part have the highest dental caries prevalence of 69.8 percent with dmft affecting 3.63 teeth on average. Fluoride is widely accepted as the most effective tool to caries prevention for initial caries lesions. Current best practice recommends twice-daily tooth brushing with fluoride toothpaste for dentate children.

CPP-ACP can bolster the effects of fluoridated toothpaste alone to prevent caries.Currently, almost all clinical trials have investigated the effectiveness of CPP-ACP containing products in dental caries prevention and enhancing remineralization of initial carious lesion in the permanent dentition of young adolescents. There are no clinical studies of the effect of a CPP-ACP containing product to prevent dental caries in the primary dentition of young children.

Arms:
arm 1: 10% w/v Calcium Phosphopeptide Amorphous Calcium Phosphate paste arm 2: the paste without Calcium phosphopeptide - Amorphous Calcium Phosphate

Interventions: intervention 1: 10 % w/v CPP-ACP paste intervention 2: the paste without CPP-ACP
Intervention descriptions: intervention 1: Apply once a day at school by school teacher, following fluoride toothbrushing after lunch intervention 2: Apply once a day at school by school teacher, following fluoride toothbrushing after lunch.

Protocol document: