Conditions: Raynaud
Keywords: Secondary Raynaud's Phenomenon
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 10
Healthy volunteers: no

Brief summary:
The investigators propose that tadalafil will increase digital blood flow and improve the symptoms and signs of secondary Raynaud's phenomenon.

Detailed description:
The primary goal of our study is to decrease the frequency, duration and severity of vasospastic attacks in patients with secondary Raynaud's. The secondary goal is to document increased blood flow and lessened capillary dysfunction in these patients. Both of these goals are to be achieved using a course of treatment with Tadalafil.We anticipate a decrease in the frequency, duration and severity of Raynaud's attacks. Improved digital blood flow and digital blood pressures, and a decrease in digital capillary dysfunction.

Arms:
arm 1: Subjects will receive tadalafil 20mg every other day for the first month, and then placebo for the second month. arm 2: Subjects will receive placebo for the first month, and tadalafil 20mg orally every other day for the second month.

Interventions: intervention 1: Tadalafil
Intervention descriptions: intervention 1: Subjects will be randomized to receive either tadalafil for the first month followed by placebo or placebo for the first month and followed by tadalafil

Protocol document: