Conditions: Renal Impairment
Keywords: Betrixaban Renal impairment Healthy Kidney dysfunction
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 32
Healthy volunteers: yes

Brief summary:
The purpose of the study is to compare the pharmacokinetics, pharmacodynamics, and tolerability of betrixaban in patients with mild, moderate, and severe renal impairment to healthy volunteers.

Detailed description:

Arms:
arm 1: Healthy subjects matched to the renal impairment groups arm 2: Patients with mild renal impairment arm 3: Patients with moderate renal impairment arm 4: Patients with severe renal impairment

Interventions: intervention 1: Betrixaban
Intervention descriptions: intervention 1: 80 mg betrixaban qd for 8 days

Protocol document: