Conditions: Arthritis, Rheumatoid
Keywords: rheumatoid arthritis DMARD methotrexate
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 100
Healthy volunteers: no

Brief summary:
CE-224,535 is known to block a chemical that acts as a gateway to some of your immune cells. Blocking this gateway prevents the cells from pushing out 2 chemicals called IL-1 and IL-18 that are known to cause some of the inflammation seen in rheumatoid arthritis. It is hoped that taking this drug will reduce the symptoms of rheumatoid arthritis

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: CE-224,535 intervention 2: Placebo
Intervention descriptions: intervention 1: 500 mg po BID intervention 2: no active ingredient

Protocol document: