Conditions: Alcoholism
Keywords: N-acetylcysteine Alcoholism Treatment
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 46
Healthy volunteers: no

Brief summary:
The present study is designed to find out if N-acetylcysteine works in reducing alcohol drinking and craving.

Detailed description:
The 2 groups (placebo and N-acetylcysteine) will be compared in a double-blind, placebo-controlled trial. The total study duration is 9 weeks which includes a 1-week screening period and an 8-week randomized study drug treatment period.

Arms:
arm 1: Patients will take oral N-acetylcysteine 900 mg/day for 1 week, 1800 mg/day for 1 week, 2700 mg/day for 1 week, and then 3600 mg/day. arm 2: Patients will take oral placebo (identical matching placebo) during the study period.

Interventions: intervention 1: N-acetylcysteine intervention 2: Placebo
Intervention descriptions: intervention 1: Patients will take oral N-acetylcysteine 900 mg/day for 1 week, 1800 mg/day for 1 week, 2700 mg/day for 1 week, and then 3600 mg/day. intervention 2: Patients will take oral placebo (identical matching placebo) during the study period.

Protocol document: