Conditions: Anorexia Cachexia Weight Loss
Keywords: Megestrol acetate Anorexia Cachexia Cancer Unintended weight loss Body weight Appetite Megace ES
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 4
Healthy volunteers: no

Brief summary:
To compare the effect of megestrol acetate concentrated suspension and placebo on caloric intake in patients with cancer-associated anorexia.

Detailed description:

Arms:
arm 1: Megestrol acetate concentrated suspension 110 mg/mL arm 2: Megestrol acetate concentrated suspension 60 mg/mL arm 3: None

Interventions: intervention 1: Megestrol acetate concentrated suspension 110 mg/mL intervention 2: Megestrol acetate concentrated suspension 60 mg/mL intervention 3: Placebo
Intervention descriptions: intervention 1: Megestrol acetate concentrated suspension 110 mg/mL given as an oral dose of 550 mg (5 mL) once per day for 56 days, with an optional 28 days extension phase intervention 2: Megestrol acetate concentrated suspension 60 mg/mL given as an oral dose of 300 mg (5 mL) once per day for 56 days, with an optional 28 days extension phase intervention 3: Placebo oral suspension, 5 mL once daily

Protocol document: