Conditions: Type 2 Diabetes
Keywords: Mechanism of action insulin sensitivity
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 36
Healthy volunteers: no

Brief summary:
This study is designed to assess the potential mechanism of action by which WelChol® (colesevelam) may improve blood glucose control in patients with type 2 diabetes

Detailed description:

Arms:
arm 1: colesevelam 3.8g administered daily for 12 weeks arm 2: Colesevelam matching placebo for 12 weeks arm 3: open-label Insulin Glargine for 12 weeks

Interventions: intervention 1: Colesevelam intervention 2: Colesevelam matching placebo intervention 3: Insulin glargine (Lantus)
Intervention descriptions: intervention 1: Colesevelam 3.8g for 12 weeks intervention 2: Colesevelam matching placebo for 12 weeks intervention 3: Insulin glargine for 12 weeks

Protocol document: