Conditions: Normal Pressure Hydrocephalus
Keywords: Amyloid Normal pressure hydrocephalus (NPH) Positron Emission Tomography (PET) Standard uptake value ratios (SUVR)
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 12
Healthy volunteers: no

Brief summary:
To determine the level of association between the quantitative estimates of brain uptake of \[18F\]flutemetamol and the quantitative immunohistochemical and histochemistry estimates of amyloid levels in frontal lobe biopsy samples obtained from subjects during shunt placement for NPH.

Detailed description:

Arms:
arm 1: None

Interventions: intervention 1: [18F]Flutemetamol
Intervention descriptions: intervention 1: All subjects will receive an IV dose of \[18F\]flutemetamol (less than 10 mg flutemetamol). The nominal activity of a single administration of \[18F\]flutemetamol will be 185 MBq.

Protocol document: