Conditions: Type 2 Diabetes Mellitus
Keywords: Beta cell function Type 2 diabetes Combination treatment
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 84
Healthy volunteers: no

Brief summary:
It has been shown in previous study that progressive glycemic deterioration was associated with progressive loss of b-cell function, measured by the decrease in plasma insulin levels, irrespective of the therapy used (diet, sulfonylureas or metformin).There is growing evidence that thiazolidinediones could have a positive action on the b-cell function. But it has not yet been demonstrated that they could protect from a deterioration in insulin secretion in the long term. So, it appears interesting to study the long term evolution of the b-cell function and the possible protection with rosiglitazone in patients with type 2 diabetes showing evidence of loss of b-cell function with metformin alone.

Detailed description:

Arms:

Interventions: intervention 1: rosiglitazone-metformin intervention 2: Metformin intervention 3: metformin+ gliclazide
Intervention descriptions: intervention 1: None intervention 2: None intervention 3: None

Protocol document: