Conditions: Psoriasis Vulgaris
Keywords: psoriasis, indigo naturalis
Allocation: RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 38
Healthy volunteers: yes

Brief summary:
To compare the efficacy and safety of refined indigo naturalis ointment with that of crude ointment in treating psoriasis.

Detailed description:
Our previous studies have shown that topical application of indigo naturalis significantly improves psoriatic symptoms. However, patient compliance is hindered because the preparation is unsightly and stains clothing.

To improve patient compliance, we have developed a refined formulation in which closer to natural skin tones and less prone to stain clothing. In this study, we evaluated the efficacy and safety of this refined form of oil extract ointment and compared the results with those of the original crude form of indigo naturalis ointment in treating psoriasis.

Arms:
arm 1: Refined indigo naturalis ointment was applied topically to one of 2 bilaterally symmetrical psoriatic plaque lesions of the same patient for 8 weeks, starting on the date of enrollment in the study arm 2: Crude indigo naturalis ointment was applied topically to one of 2 bilaterally symmetrical psoriatic plaque lesions of the same patient for 8 weeks, starting on the date of enrollment in the study

Interventions: intervention 1: refined indigo naturalis ointment intervention 2: crude indigo naturalis ointment
Intervention descriptions: intervention 1: The patients applied either refined oil extract or crude indigo naturalis ointmnet topically to each of two bilaterally symmetrical psoriatic plaque lesions for 8 weeks. intervention 2: The patients applied either refined oil extract or crude indigo naturalis ointmnet topically to each of two bilaterally symmetrical psoriatic plaque lesions for 8 weeks.

Protocol document: