Conditions: Opioid-Induced Hyperalgesia
Keywords: opioid-induced hyperalgesia methadone gabapentin opioid addiction
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 26
Healthy volunteers: no

Brief summary:
Utilizing a double-blind, placebo-controlled design, the proposed work will evaluate the ability of an adjuvant anticonvulsant analgesic to diminish or reverse the opioid-induced hyperalgesia complicating the pain states suffered by Methadone-Maintained (MM) patients. Specifically, in a sample of MM patients, gabapentin, which has proven efficacy in treating neuropathic pain will be evaluated for its ability to ameliorate or diminish the opioid-induced hyperalgesia in these patients as reflected by changes on pain threshold and tolerance to both cold-pressor and electrical pain, at peak and through methadone blood levels. The results of this work will not only provide pharmacologic insight into the mechanisms underlying poor pain tolerance in this at-risk population, but also direction for the medical management of pain complicated by opioid-induced hyperalgesia.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Gabapentin; intervention 2: Placebo
Intervention descriptions: intervention 1: Gabapentin titrated to daily dose of 2400mg PO over 1 week with established dose taken daily for 5 weeks. intervention 2: Placebo titrated over 1 week with established dose taken daily for 5 weeks.

Protocol document: