Conditions: Osteoarthritis Postoperative Pain
Keywords: opioid
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 307
Healthy volunteers: no

Brief summary:
Pregabalin added to the standard of care with dosing starting preoperatively and continuing for up to 6 weeks post surgery will decrease the intensity of post-operative pain following total knee replacement.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None

Interventions: intervention 1: pregabalin intervention 2: pregabalin intervention 3: Placebo
Intervention descriptions: intervention 1: 150 milligram (mg)/ day (double blind) intervention 2: 300 mg/day (double blind) intervention 3: Placebo

Protocol document: