Conditions: Heart Failure
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 17
Healthy volunteers: no

Brief summary:
Heart failure (HF) is a complex condition resulting from structural or functional heart diseases that impair the ability of the heart to fill with or pump out blood. The main manifestations of HF are shortness of breath and tiredness which may limit the ability to exercise or perform simple daily physical activities such as walking. Heart disease leading to HF is associated with reduced muscle mass and reduced strength and low blood levels of testosterone; a hormone normally produced by the human (male and female) body. Recent studies have shown improvements of symptoms and ability to exercise in patients with heart failure receiving testosterone.

This is a placebo controlled study to determine the efficacy and safety of low dose testosterone (300 and 450 microgram/day) delivered by a transdermal system (patch) in women with significant HF.

Detailed description:

Arms:
arm 1: placebo patch arm 2: 300 micrograms/day transdermal testosterone patch arm 3: 450 micrograms/day transdermal testosterone patch

Interventions: intervention 1: placebo intervention 2: testosterone
Intervention descriptions: intervention 1: placebo patch intervention 2: 300 or 450 micrograms/day transdermal testosterone patch

Protocol document: