Conditions: Langerhans Cell Histiocytosis
Keywords: Langerhans Cell Histiocytosis LCH 6-Thioguanine 6-TG Methotrexate MTX 94-132
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 5
Healthy volunteers: no

Brief summary:
The objective of this study is to determine the incidence of complete and partial response and the duration of response in patients with Langerhans Cell Histiocytosis (LCH) treated with sequential administration of oral 6-Thioguanine (6-TG) after Methotrexate (MTX).

Detailed description:

Arms:
arm 1: MTX, 6-TG, Leucovorin

Interventions: intervention 1: Methotrexate intervention 2: 6-Thioguanine intervention 3: Leucovorin Calcium
Intervention descriptions: intervention 1: MTX 30mg/m2 (or 1mg/kg for infants) orally, given in three equally divided doses at 0,8, and 16hrs intervention 2: 6-TG 300mg/m2 (or 10mg/kg for infants) orally, given in one dose. intervention 3: 5mg orally at 36,48, and 60hrs (or 12 hrs after the dose of 6-TG and then every 12 hrs for a total of 3 doses)

Protocol document: