Conditions: Pain
Keywords: propofol lidocaine injection pain
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 156
Healthy volunteers: no

Brief summary:
Injection of propofol is associated with discomfort in subsets of patients. Local anesthetics have been shown to attenuate this response in some patients. This randomized, double-blind, placebo-controlled trial tests the hypothesis that lidocaine mixed with propofol will be superior to lidocaine administered directly into the vein, under tourniquet control, prior to injection of propofol. Both groups are expected to be superior to placebo.

Detailed description:

Arms:
arm 1: Saline pretreatment, saline admixture arm 2: Lidocaine pretreatment / saline-propofol admixture arm 3: saline pretreatment / Lidocaine-propofol admixture

Interventions: intervention 1: Saline intervention 2: Lidocaine / propofol admixture intervention 3: lidocaine pretreatment
Intervention descriptions: intervention 1: 3.3 mL normal saline intervention 2: lidocaine 50 mg plus propofol 50 mg intravenous (iv) intervention 3: lidocaine 50 mg iv under tourniquet-control

Protocol document: