Conditions: Insulin Resistance Diabetes Mellitus
Keywords: Insulin Resistance Diabetes mellitus Antipsychotic
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 15
Healthy volunteers: yes

Brief summary:
The purpose of this clinical research study is to examine the acute hormonal and metabolic effects of the drug olanzapine, as well as appetite effects, in healthy volunteers. The hypotheses to be tested are that: (1) Olanzapine rapidly attenuates plasma leptin and (2) rapidly alters glucose tolerance in healthy volunteers. These questions will be answered by having volunteers undergo two glucose tolerance tests in a crossover study design.

Detailed description:

Arms:
arm 1: Placebo arm 2: Olanzapine 10mg po daily x 3 days

Interventions: intervention 1: Olanzapine 10 mg po qhs for 3 days intervention 2: Placebo
Intervention descriptions: intervention 1: (1) 10 mg tablets administered orally before bed for three consecutive evenings (Total Dose = 30 mg, 3 tablets) intervention 2: (1) placebo tablets administered orally before bed for three consecutive evenings (Total Dose = 3 tablets)

Protocol document: