Conditions: Rheumatoid Arthritis
Keywords: cholesterol lipids rheumatoid arthritis CP-690 550
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 111
Healthy volunteers: no

Brief summary:
All patients will be in instructed to eat a therapeutic lifestyle diet and will receive CP-690,550 throughout the 12 weeks of this study. After 6 weeks, half will receive the cholesterol lowering agent, atorvastatin, and half a matching placebo. This study will first measure the effects of CP-690,550 on cholesterol levels and then the effects of adding atorvastatin on those levels.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: CP-690,550 intervention 2: Atorvastatin intervention 3: CP-690,550 intervention 4: Atorvastatin Placebo
Intervention descriptions: intervention 1: 12 week open-label CP-690,550 10 mg oral tablets administered twice daily starting at Day 0 through Week 12 intervention 2: Starting at Week 6 and continuing through Week 12 atorvastatin 10 mg oral tablets administered once daily intervention 3: 12 week open-label CP-690,550 10 mg oral tablets administered twice daily starting at Day 0 through Week 12 intervention 4: Starting at Week 6 and continuing through Week 12 atorvastatin placebo tablets administered once daily

Protocol document: