Conditions: Alcoholism Cocaine Dependence
Keywords: Topiramate alcoholism cocaine dependence
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 170
Healthy volunteers: no

Brief summary:
The primary purpose of this study is to test the effectiveness of topiramate for the treatment of combined alcohol and cocaine dependence. Topiramate is approved for the treatment of seizures. It has not been proven to be effective for the treatment of alcohol or cocaine dependence.

Detailed description:
The purpose of this study is to evaluate the efficacy of 300 mg/day of topiramate for the treatment of 200 treatment-seeking alcohol dependent outpatients with comorbid cocaine dependence in a double-blind, placebo-controlled 14-week trial, with a 6-month follow-up (3 months after completing medications).

Arms:
arm 1: topiramate capsules dose titrated up to 300 mg daily arm 2: placebo capsules identical in appearance to the topiramate capsules

Interventions: intervention 1: Topiramate intervention 2: placebo
Intervention descriptions: intervention 1: 300mg/day for 13 weeks intervention 2: placebo pills

Protocol document: