Conditions: Preterm Birth
Keywords: Preterm birth, prevention, progesterone, oral
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 36
Healthy volunteers: no

Brief summary:
To evaluate whether daily oral micronized progesterone is effective in preventing recurrent spontaneous preterm birth (RSPB) and whether micronized progesterone use increases maternal serum progesterone levels.

Detailed description:
To evaluate whether 400 mg daily oral micronized progesterone from 16 to 34 weeks' is effective in preventing recurrent spontaneous preterm birth (RSPB) and whether micronized progesterone use increases maternal serum progesterone levels.

Arms:
arm 1: Oral Micronized Progesterone arm 2: Identical Placebo Tablet

Interventions: intervention 1: oral micronized progesterone intervention 2: Identical Placebo tablet
Intervention descriptions: intervention 1: oral micronized progesterone = 400 mg oral micronized progesterone nightly from 16 to 34 weeks intervention 2: Identical Placebo tablet = placebo taking nightly from 16 to 34 weeks

Protocol document: