Conditions: Depression
Keywords: Severe Depressive Episode
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 750
Healthy volunteers: no

Brief summary:
The purpose of this study is to compare duloxetine with other antidepressants in the treatment of severe depression.

Detailed description:

Arms:
arm 1: study drug arm 2: None arm 3: None arm 4: None arm 5: None

Interventions: intervention 1: duloxetine intervention 2: fluoxetine intervention 3: citalopram intervention 4: paroxetine intervention 5: sertraline
Intervention descriptions: intervention 1: 30-120 milligrams (mgs) orally daily for 12 weeks intervention 2: 20-80 mgs orally daily for 12 weeks intervention 3: 20-40 mgs orally daily for 12 weeks intervention 4: 20-50 mgs orally daily for 12 weeks intervention 5: 50-200 mgs orally daily for 12 weeks

Protocol document: