Conditions: Reflux Esophagitis
Keywords: Reflux Esophagitis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 540
Healthy volunteers: no

Brief summary:
The primary objective of this study is to evaluate the efficacy of esomeprazole 20 mg once daily for 24 weeks on maintenance of Reflux Esophagitis in patients with healed reflux esophagitis in comparison with omeprazole 10 mg once daily and esomeprazole 10 mg once daily by assessment of presence/absence of recurrence of Reflux Esophagitis throughout the treatment period (from the randomisation to the treatment completion) according to the Los Angeles classification.

Detailed description:

Arms:
arm 1: Esomeprazole and Omeprazole arm 2: Esomeprazole

Interventions: intervention 1: Esomeprazole intervention 2: Esomeprazole intervention 3: Omeprazole
Intervention descriptions: intervention 1: 10mg once daily oral administration intervention 2: 20mg once daily oral administration intervention 3: 10mg once daily oral administration

Protocol document: