Conditions: Pulmonary Hypertension
Keywords: Pulmonary artery systolic pressure (PASP) Pulmonary Vascular Resistance (PVR) Right Heart Catheterization Pulmonary hemodynamics
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 30
Healthy volunteers: no

Brief summary:
The design of this study is to conduct a comprehensive safety evaluation of the pulmonary hemodynamic effects of Optison. The study is being conducted in subjects referred for cardiac catheterization for clinical reasons.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Optison (Perflutren Protein-Type A Microspheres Injectable Suspension) intervention 2: Dextrose
Intervention descriptions: intervention 1: Arm A: Single intravenous (IV) injection of 0.5 mL Optison followed by single IV injection of 0.5 mL 5% dextrose.

Arm B: Single IV injection of 0.5 mL 5% dextrose followed by single IV injection of 0.5 mL Optison. intervention 2: Arm A: Single intravenous (IV) injection of 0.5 mL Optison followed by single IV injection of 0.5 mL 5% dextrose.

Arm B: Single IV injection of 0.5 mL 5% dextrose followed by single IV injection of 0.5 mL Optison.

Protocol document: