Conditions: Heart Failure
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 2
Healthy volunteers: no

Brief summary:
The purpose for this study (CY 1124) is to evaluate the effects of CK-1827452, a cardiac myosin activator, on myocardial systolic performance, myocardial oxygen consumption, and myocardial efficiency in patients with heart failure and to confirm that the unique preclinical pharmacological profile of CK- 1827452 is substantially the same in patients with heart failure.

Detailed description:

Arms:
arm 1: 0.5 hour loading dose followed by 1.0 hour maintenance dose of CK-1827452 arm 2: ≤ 1.0 hour loading dose followed by 1.0 hour maintenance dose of CK-1827452

Interventions: intervention 1: CK-1827452 intervention 2: CK-1827452
Intervention descriptions: intervention 1: I.V. infusion for 0.5 hour at 54mg/hr followed by 1 hour at 21mg/hr intervention 2: I.V. infusion for ≤ 1 hour at 72mg/hr followed by 1 hour at 36mg/hr

Protocol document: