Conditions: Diabetes Mellitus, Type 1
Keywords: type 1 Diabetes mellitus, pharmacokinetics, pharmacodynamics Adult male and females,
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 10
Healthy volunteers: no

Brief summary:
The purpose of this research study is to look at concentrations of GSK189075 in blood when single doses of the drug are taken by mouth in combination with basal insulin. The clinical effects of the drug in combination with insulin on the body will also be studied. The results will help determine doses of GSK189075 can be studied in the future in the type I diabetes mellitus population.

Detailed description:

Arms:
arm 1: GSK189075 arm 2: Placebo

Interventions: intervention 1: GSK189075 intervention 2: placebo
Intervention descriptions: intervention 1: investigational drug intervention 2: placebo comparator

Protocol document: