Conditions: Type 2 Diabetes Mellitus
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 12
Healthy volunteers: yes

Brief summary:
This study will evaluate the effect of a single dose of sitagliptin on glucose dependent insulin secretion using a meal tolerance test (MTT) during a hyperglycemic clamp (HCG) procedure.

Detailed description:

Arms:
arm 1: Sitagliptin in 2 of 3 treatment periods and Placebo in 1 of 3 treatment periods arm 2: Sitagliptin in 2 of 3 treatment periods and Placebo in 1 of 3 treatment periods arm 3: Sitagliptin in 2 of 3 treatment periods and Placebo in 1 of 3 treatment periods

Interventions: intervention 1: sitagliptin intervention 2: Comparator: Placebo
Intervention descriptions: intervention 1: Single oral dose of sitagliptin 100 mg (2 x 50 mg) tablets followed by the hyperglycemic clamp procedure and meal tolerance test. intervention 2: Single oral dose of 2 tablets placebo to sitagliptin followed by the hyperglycemic clamp procedure and meal tolerance test.

Protocol document: