Conditions: Recovery Time Bruising
Keywords: Nasal Surgery Septorhinoplasty fibrin glue fibrinogen Swelling fibrin tisseel
Allocation: RANDOMIZED | Intervention model: FACTORIAL
Enrollment: 25
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine whether the use of fibrin glue during nasal surgery leads to a shorter recovery period with less bruising and/or swelling.

Detailed description:
Septorhinoplasty is a well established technique to correct nasal deformity. Drawbacks of this procedure include a significant recovery following surgery which may often require nasal taping and casting. Swelling and bruising in and around the surgical site may persist for months after the operation. At present, there is no standard regarding the length of time nasal tape and cast should be used following septorhinoplasty. It has never been proven that taping or casting is required - in surgeries that require minimal amounts of tissue handling, we may not use any tape or cast following the procedure. Homologous fibrin glue has been used for various cosmetic facial plastic procedures since the early 1980's. It has been shown to decrease bruising and swelling following surgery. This study is being undertaken to evaluate these benefits of using fibrin glue in nasal surgery.

Arms:
arm 1: Septorhinoplasty with postoperative application of nasal taping and an external nasal cast. The tape and cast will be left in place for one week. No tissue glue will be used during the operation, although the nurse and surgical assistant will simulate the preparation and insertion of tissue glue using a syringe containing saline. arm 2: Septorhinoplasty will be performed. At the termination of the procedure, prior to closure, fibrin sealant will be applied by the surgical assistant to the surgical site. Approximately 0.5 cc to 2 cc of tissue sealant will be applied. After closure, tape and cast will be applied and left in place for one week. arm 3: Septorhinoplasty will be performed. At the termination of the procedure, prior to closure, 0.5 cc to 2 cc of tissue sealant will be applied. Nasal tape will be applied after closure.

Interventions: intervention 1: Fibrinogen intervention 2: Septorhinoplasty intervention 3: Taping after septorhinoplasty. intervention 4: Cast applied to the nose after nasal surgery intervention 5: Saline
Intervention descriptions: intervention 1: One time application of 0.5 cc to 2.0 cc of fibrinogen following surgery. intervention 2: Septorhinoplasty to correct nasal deviation. intervention 3: Simple taping over the nose following nasal surgery. intervention 4: A molded cast will be placed on top of the nose following nasal surgery. intervention 5: Approximately 0.5 cc to 2 cc normal saline will be applied after the operation before the nasal taping and casting.

Protocol document: