Conditions: Dyslipidemia
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 177
Healthy volunteers: no

Brief summary:
This Phase 2 proof-of-concept study will assess the lipid regulating efficacy and safety of ETC-1002 in subjects with hypercholesterolemia and either normal or elevated triglycerides.

Detailed description:

Arms:
arm 1: Subjects with hypercholesterolemia and normal triglycerides arm 2: Subjects with hypercholesterolemia and normal triglycerides arm 3: Subjects with hypercholesterolemia and normal triglycerides arm 4: Subjects with hypercholesterolemia and normal triglycerides arm 5: Subjects with hypercholesterolemia and elevated triglycerides arm 6: Subjects with hypercholesterolemia and elevated triglycerides arm 7: Subjects with hypercholesterolemia and elevated triglycerides arm 8: Subjects with hypercholesterolemia and elevated triglycerides

Interventions: intervention 1: ETC-1002 intervention 2: Placebo
Intervention descriptions: intervention 1: ETC-1002 daily for 12 weeks intervention 2: Placebo daily for 12 weeks

Protocol document: