Conditions: Glaucoma
Keywords: Glaucoma
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 86
Healthy volunteers: no

Brief summary:
The purpose of this study was to assess the efficacy of adding Azopt dosed three times a day to Xalatan as compared to that of adding placebo to Xalatan in patients with elevated intraocular pressure.

Detailed description:

Arms:
arm 1: Xalatan dosed once a day at 10 pm, with Azopt dosed three times a day at 8 AM, 2 PM, and 10:05 PM as an adjunctive therapy for 3 months. arm 2: Xalatan dosed once a day at 10 pm, with placebo dosed three times a day at 8 AM, 2 PM, and 10:05 PM concomitantly for 3 months.

Interventions: intervention 1: Brinzolamide 1% ophthalmic solution (Azopt) intervention 2: Placebo eye drops intervention 3: Latanoprost 0.005% ophthalmic solution (Xalatan)
Intervention descriptions: intervention 1: One drop three times a day in both eyes for 3 months intervention 2: One drop three times a day in both eyes for 3 months intervention 3: One drop once a day in both eyes for 3 months

Protocol document: