Conditions: Diabetic Autonomic Neuropathy
Keywords: Type 1 Diabetes Oxidative Stress Diabetic Complications Neuropathy
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 44
Healthy volunteers: no

Brief summary:
The focus of this project is cardiovascular diabetic autonomic neuropathy (DAN). DAN affects the nerves that control heart rate and blood flow to the heart in people with diabetes. DAN may cause problems with the rhythm of the heartbeat or decrease blood flow to the heart. Three medications will be tested for their effectiveness in DAN.

Detailed description:

Arms:
arm 1: Allopurinol (300mg daily), ALA (600mg twice daily) nicotinamide (750 mg twice daily) Given orally These drugs were given together as a combination and not as individual treatment. arm 2: Placebo administered twice daily.

Interventions: intervention 1: ORAL ANTIOXIDANT
Intervention descriptions: intervention 1: Comparison of triple antioxidant combination therapy vs placebo.

Protocol document: