Conditions: Pharmacokinetics Renal Impaired Healthy Volunteer
Keywords: LCZ696 pharmacokinetics
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 12
Healthy volunteers: yes

Brief summary:
An open label, parallel-group study to determine multiple dose pharmacokinetics of LCZ696 and its metabolites in subjects with severe renal impairment compared to matched healthy subjects with normal renal function

Detailed description:

Arms:
arm 1: once daily administration of 400 mg LCZ696 for 5 days arm 2: once daily administration of 400 mg LCZ696 for 5 days

Interventions: intervention 1: LCZ696A intervention 2: LCZ696A
Intervention descriptions: intervention 1: None intervention 2: once daily administration of 400 mg LCZ696 for 5 days

Protocol document: