Conditions: Diverticulosis, Colonic Rectal Neoplasms Colonic Neoplasms
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 23
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine the tissue kinetics of ertapenem in colonic tissue from three hours up to six hours (25% of dosing interval) after administration of ertapenem.

Detailed description:
The purpose of this study is to determine the tissue kinetics of ertapenem in colorectal tissue from three hours up to six hours (25% of dosing interval) after administration of ertapenem before an elective surgical intervention (open or laparoscopic surgery) at the colon/rectum. Subjects are patients. Hospitalized patients 18 years or older requiring elective surgical intervention (open or laparoscopic surgery) at the colon will be eligible for this study.

Arms:
arm 1: Administration of 1 gram ertapenem I.V.

Interventions: intervention 1: Ertapenem
Intervention descriptions: intervention 1: powder for infusion, 1 gram I.V., single dose over 30 min.

Protocol document: