Conditions: Hypertension Type 2 Diabetes Mellitus
Keywords: beta-blockers endothelial function
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 36
Healthy volunteers: no

Brief summary:
The purpose of this study is to compare the vascular effects of two commonly used blood pressure medications, carvedilol and metoprolol in hypertensive patients with type 2 diabetes.

Detailed description:
Carvedilol and metoprolol are two commonly used blood pressure medications that have both been shown to be effective in controlling hypertension. Although in the same drug class, preliminary data have shown that these medications may have different vascular effects. This study will assess which medication is better at improving artery health independent of their blood pressure lowering effects. Artery health will be assessed non-invasively by ultrasound. Certain markers of atherosclerosis found in the blood will also be measured.

Arms:
arm 1: Carvedilol, orally, 25 mg, twice daily for five months arm 2: Metoprolol, orally, 200 mg, twice daily for five months.

Interventions: intervention 1: Carvedilol intervention 2: Metoprolol
Intervention descriptions: intervention 1: 25 mg twice daily for five months. intervention 2: 200 mg twice daily for five months.

Protocol document: