Conditions: Constipation
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 128
Healthy volunteers: no

Brief summary:
The primary purpose of this study is to evaluate the safety and dose-response relationship of N-methylnaltrexone bromide (MOA-728) by observing spontaneous bowel movements in subjects administered MOA-728 who have chronic pain that is not due to cancer, and who have opioid-induced bowel dysfunction (OIBD).

Detailed description:

Arms:
arm 1: Placebo arm 2: MOA-728 arm 3: MOA-728 arm 4: MOA-728 arm 5: MOA-728

Interventions: intervention 1: MOA-728 intervention 2: Placebo
Intervention descriptions: intervention 1: Oral Capsules intervention 2: Placebo

Protocol document: