Conditions: Major Depressive Disorder
Keywords: Depression Geriatric MRI Sertraline
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 43
Healthy volunteers: yes

Brief summary:
The purpose of this study was to use Magnetic Resonance Images to further our understanding of predictors and markers of treatment response and non-response in geriatric depression. We hypothesized that concentrations of high energy metabolites would be lower in depressed elderly compared to non-depressed.

Detailed description:

Arms:
arm 1: Healthy Controls undergo MRI and neuropsychological testing arm 2: Depressed subjects receive experimental drug

Interventions: intervention 1: Sertraline
Intervention descriptions: intervention 1: Oral Sertraline Dosage started at 25 mg a day, with increases up to maximum dosage strength of 200 mg a day.

Duration of treatment was 12 weeks.

Protocol document: