Conditions: Parkinson Disease
Keywords: Parkinson disease Ropinirole
Allocation: NON_RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 82
Healthy volunteers: no

Brief summary:
1. In order to compare the benefit, side effects, and patient preference of Ropinirole prolonged release when used in once-daily or twice-daily dosing
2. In order to estimate the conversion rate of dopamine agonists into Ropinirole prolonged release

Detailed description:
1. Study subjects : Parkinson disease who are on Ropinirole immediate release or Pramipexole immediate release and are considering to change into Ropinirole prolonged release
2. Cross over study design:

   * Group 1: once daily dose for 2 month then into twice daily in divided dose for 2 months
   * Group 2: twice daily in divided dose for 2 months then into once daily dose for 2 months
3. Dose adjustment may be done in the first 4 weeks.
4. Compare the benefit,side effects, and patient preference between the once daily vs twice daily dosing.

Arms:
arm 1: Give Roipinirole prolonged release (PR) once-daily (QD) dose first, then twice-daily (BID) dosing arm 2: Give Ropinirole prolonged release (PR) twice-daily (BID) dosing, and then once-daily (QD) dosing

Interventions: intervention 1: Ropinirole Prolonged release
Intervention descriptions: intervention 1: Change Ropinirole immediate release or Pramipexole immediate release to Ropinirole prolonged release (PR) once-daily or twice-daily

Protocol document: