Conditions: Deep Sedation Anesthesia, General
Keywords: depth of sedation nitrous oxide general anesthesia anesthesia indices
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 32
Healthy volunteers: no

Brief summary:
The study hypothesizes that adding 60% nitrous oxide to a steady state sevoflurance or propofol anesthetic will lead to a decrease in both BIS and Entropy indices during a constant level of surgical stimulus

Detailed description:
Nitrous oxide is a widely used general anesthetic pas. It is often used in addition to a second, more potent agent. BIS and Entropy are depth of anesthesia monitors in clinical use. There are conflicting reports about the usefulness of these monitors when nitrous oxide is used as a part of the anesthetic regimen. While some studies demonstrate a decrease in BIS and Entropy, this study aims to investigate the effects of adding nitrous oxide to a sevoflurane or a propofol based anesthetic on BIS and Entropy indices.

Arms:
arm 1: Sevoflurane based general anesthesia arm 2: Propofol based general anesthesia

Interventions: intervention 1: Sevoflurane group intervention 2: Propofol group
Intervention descriptions: intervention 1: Addition of 60% nitrous oxide for 20 minutes duration, then back to 1:1 oxygen/air mixture. intervention 2: Addition of 60% nitrous oxide for 20 minutes duration, then back to 1:1 oxygen/air mixture.

Protocol document: