Conditions: Sepsis
Keywords: severe sepsis septic shock Gram-negative infection phospholipid emulsion
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 1415
Healthy volunteers: no

Brief summary:
The primary objective is to estimate the size of the GR270773 treatment effect on 28-day all-cause mortality for two doses of GR270773 versus placebo in adult subjects with suspected or confirmed Gram-negative severe sepsis. GR270773 will be administered as a three-day continuous intravenous infusion.

Detailed description:

Arms:

Interventions: intervention 1: Intravenous GR270773- Phospholipid Emulsion intervention 2: Placebo
Intervention descriptions: intervention 1: None intervention 2: None

Protocol document: