Conditions: Gastroesophageal Reflux
Keywords: Acid reflux disease Gastroesophageal Reflux Disease
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 626
Healthy volunteers: no

Brief summary:
The study investigates the efficacy of long-term treatment of esomeprazole compared to anti-reflux surgery in the control of gastroesophageal reflux disease by assessing time to treatment failure.

Detailed description:

Arms:
arm 1: Surgery arm 2: Esomeprazole (NEXIUM) therapy

Interventions: intervention 1: esomeprazole intervention 2: Laparoscopic fundoplication (surgery)
Intervention descriptions: intervention 1: 40 mg oral tablet administered daily intervention 2: Surgery

Protocol document: