Conditions: Common Cold Infections, Upper Respiratory Tract
Keywords: randomized parallel double-blind placebo-controlled cough efficacy safety dextromethorphan
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 140
Healthy volunteers: no

Brief summary:
15 mg dextromethorphan hydrobromide will be better than placebo with respect to reducing the number of coughs over 6 hours and reducing the subjective severity of cough over 6 hours.

Detailed description:
In light of protocol changes required due to methodological and operational issues, including background noise in cough recordings which could impact data interpretation, the study has been terminated.

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Dextromethorphan intervention 2: Placebo
Intervention descriptions: intervention 1: A single 10 mL dose of Children's Triaminic Syrup (Dextromethorphan Hydrobromide 7.5 mg per 5 mL (total dose of 15 mg) intervention 2: A single 10 mL dose of matching placebo syrup

Protocol document: