Conditions: COPD
Keywords: COPD QVA149 tiotropium exercise exercise tolerance combination bronchodilator moderate to severe COPD
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 85
Healthy volunteers: no

Brief summary:
This study assessed the effect of once-daily indacaterol and glycopyrronium bromide (QVA149) on exercise endurance in patients with moderate to severe Chronic Obstructive Pulmonary Disease (COPD).

Detailed description:

Arms:
arm 1: QVA149 delivered once daily via single-dose dry powder inhaler. arm 2: Placebo, delivered once daily via single-dose dry powder inhaler. arm 3: Tiotropium delivered once daily via HandiHaler® device.

Interventions: intervention 1: indacaterol and glycopyrronium bromide (QVA149) intervention 2: placebo intervention 3: tiotropium
Intervention descriptions: intervention 1: None intervention 2: None intervention 3: None

Protocol document: