Conditions: Skin Diseases, Infectious Soft Tissue Infections
Keywords: Complicated Skin and Soft Tissue Infections. Daptomycin, Vancomycin, Teicoplanin Complicated skin and soft tissue infections
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 194
Healthy volunteers: no

Brief summary:
This study evaluated the efficacy and safety of daptomycin compared to vancomycin or teicoplanin for the treatment of complicated skin and soft tissue infections

Detailed description:

Arms:
arm 1: 4 mg/kg intravenous (i.v.) once daily arm 2: None

Interventions: intervention 1: Daptomycin intervention 2: Vancomycin intervention 3: Teicoplanin
Intervention descriptions: intervention 1: 4 mg/kg intravenous once daily intervention 2: 1 g intravenous twice daily intervention 3: 400 mg intravenous once daily following a loading dose of 400 mg administered at 0, 12, 24 hours on day one.

Protocol document: