Conditions: Substance-Related Disorders
Keywords: cognitive-behavior therapy d-cycloserine cognitive enhancer drug dependence opiate dependence exposure isolated doses of d-cycloserine isolated doses of matching pill placebo DCS
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 15
Healthy volunteers: no

Brief summary:
This study examines whether isolated doses of d-cycloserine enhance the efficacy of an exposure-based cognitive-behavioral treatment for chronic and treatment refractory substance dependence.

Detailed description:
This is a placebo-controlled trial of the efficacy of 50mg d-cycloserine or matching pill placebo for enhancing the efficacy of CBT.

Arms:
arm 1: D-cycloserine-augmented CBT-IC arm 2: Placebo-augmented CBT-IC

Interventions: intervention 1: D-cycloserine intervention 2: Placebo
Intervention descriptions: intervention 1: Single dosage of D-cycloserine is given prior to each of 6 sessions of CBT-IC treatment (sessions 5-10) intervention 2: Single dosage of placebo is given prior to each of 6 sessions of CBT-IC treatment (sessions 5-10)

Protocol document: