Conditions: Healthy Volunteer
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 24
Healthy volunteers: yes

Brief summary:
A single-center, crossover study to evaluate the pharmacokinetics of dalcetrapib and atorvastatin from prototype fixed dose combination formulations in healthy volunteers. Volunteers will receive a single dose of dalcetrapib with atorvastatin in each of four treatment periods.

Detailed description:

Arms:
arm 1: RO5317116/F01 bilayer tablet arm 2: RO5317116/F03 bilayer tablet arm 3: RO5317116/F04 active-coated tablet arm 4: RO4607381/F49 tablet

Interventions: intervention 1: atorvastatin intervention 2: dalcetrapib
Intervention descriptions: intervention 1: single dose of atorvastatin on day 1 intervention 2: single dose of dalcetrapib on day 1

Protocol document: