Conditions: Acute Decompensated Heart Failure
Keywords: Natriuretic peptides BNP Heart Failure Nitoglycerin Biomarkers
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 89
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine whether Nesiritide is more effective than nitroglycerin in modifying inflammatory and neurohormonal biomarkers without renal toxicity when proper infusion duration is administered.

Detailed description:
No additional details provided

Arms:
arm 1: Nesiritide: 2 mcg/kg bolus (optional) followed by 0.01 mcg/kg/min infusion for 48 hours. arm 2: Nitroglycerin was initiated at 10 mcg/min initial starting dose titrated every 5-10 minutes until symptom relief, SBP\<or= 90 mm Hg, or up to a maximum rate of 200 mcg/min plus standard treatment.

Interventions: intervention 1: Nesiritide intervention 2: Nitroglycerin
Intervention descriptions: intervention 1: Bolus 2 mcg/kg followed by 0.01 mcg/kg/min intervention 2: 5-10 mcg/min titrating per protocol based on blood pressure

Protocol document: