Conditions: Healthy
Keywords: healthy, no evidence of disease
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 11
Healthy volunteers: yes

Brief summary:
RATIONALE: Lorazepam, diphenhydramine hydrochloride, and haloperidol gel, when absorbed into the skin, may be an effective treatment for nausea and vomiting.PURPOSE: This clinical trial studies lorazepam, diphenhydramine hydrochloride, and haloperidol gel in healthy volunteers.

Detailed description:
OBJECTIVES:I. To study the absorption of the three components in the topical ABH gel in 10 healthy volunteers, and determine if there are any adverse effects. OUTLINE: Patients apply lorazepam, diphenhydramine hydrochloride, and haloperidol gel topically over 2 minutes. After completion of study treatment, patients are followed up for 5 hours.

Arms:
arm 1: Patients apply lorazepam, diphenhydramine hydrochloride, and haloperidol gel topically over 2 minutes.

Interventions: intervention 1: lorazepam intervention 2: diphenhydramine hydrochloride intervention 3: haloperidol intervention 4: questionnaire administration intervention 5: laboratory biomarker analysis
Intervention descriptions: intervention 1: Given topically intervention 2: Given topically intervention 3: Given topically intervention 4: Ancillary studies intervention 5: Correlative studies

Protocol document: