Conditions: Periodontitis
Keywords: Peri-implantitis; antibiotic
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 44
Healthy volunteers: no

Brief summary:
This study is for people at least 21 years old who have signs of problems, like swollen gums and shrinking bones, by dental implants.

Detailed description:
At Visit 1, the dentist will:

* do an oral exam
* ask some questions
* decide if the person qualifies for being in the study
* make an appointment for Visit 2 if they qualify

At Visit 2 (Baseline), the dentist will:

* do a special cleaning of the implants
* examine the whole mouth
* collect some fluid
* take x-rays
* put the people into one of two groups (taking into account whether or not they smoke)

  1. one group will have the study antibiotic put on all the areas in their mouth with gum problems
  2. the other group will not receive the antibiotic At Visit 3 (about a month later), only fluid samples will be collected.

At Visit 4 (about 3 months later), the dentist will:

* collect fluid samples
* examine the whole mouth
* apply the antibiotic again for people in that group

At Visit 5 (about 6 months later), the dentist will:

* collect fluid samples
* examine the whole mouth
* take x-rays

Arms:
arm 1: 1 mg microspheres of minocycline hydrochloride arm 2: Control group receiving no drug intervention

Interventions: intervention 1: Minocycline HCl
Intervention descriptions: intervention 1: 1mg microspheres for professional subgingival administration into periodontal pockets two times throughout the duration of the trial

Protocol document: