Conditions: Hypertension Diastolic Dysfunction
Keywords: Hypertension systolic blood pressure diastolic dysfunction valsartan amlodipine
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 229
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine the effects of treatment with valsartan + amlodipine to a target systolic blood pressure (SBP)\<130 mmHg compared to the Joint National Commission on the Treatment of Hypertension 7 recommended target SBP of \<140 mmHg on the intrinsic diastolic properties of the myocardium in patients with hypertension and echocardiographic evidence of diastolic dysfunction.

Detailed description:

Arms:
arm 1: (Valsartan + Amlodipine to target SBP of \< 140 mmHg) arm 2: (Valsartan + Amlodipine to target SBP \< 130 mm Hg)

Interventions: intervention 1: valsartan intervention 2: amlodipine
Intervention descriptions: intervention 1: 160 mg or 320 mg tablets once a day intervention 2: 5 mg or 10 mg tablets once a day

Protocol document: