Conditions: Coronary Atherosclerosis
Keywords: Coronary artery disease
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 2333
Healthy volunteers: no

Brief summary:
A 104-week, randomized, double-blind, parallel group, multi-center Phase IIIb study comparing the effects of treatment with rosuvastatin 40 mg or atorvastatin 80 mg on atherosclerotic disease burden as measured by intravascular ultrasound in patients with coronary artery disease.

Detailed description:

Arms:
arm 1: Rosuvastatin 20 mg distributed in 2-week run-in period arm 2: Atorvastatin 40 mg distributed in 2-week run-in period arm 3: Rosuvastatin 40 mg distributed in core 2-year study arm 4: Atorvastatin 80 mg distributed in core 2-year study

Interventions: intervention 1: Rosuvastatin intervention 2: Atorvastatin
Intervention descriptions: intervention 1: capsule, oral, once daily intervention 2: capsule, oral, one daily

Protocol document: