Conditions: Pain
Keywords: Analgesic effect Molar extraction
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 151
Healthy volunteers: yes

Brief summary:
The primary aim of this study is to investigate if AZD1940 can relieve the pain induced by the surgical removal of one lower wisdom-tooth. This will be done by comparing the effect of AZD1940 to placebo ("inactive substance") on pain. A number of patients will instead receive the common painkiller naproxen for comparison purposes. Rescue medication, acetaminophen, will be allowed if a need for additional painkillers would arise. A number of patients will receive Naproxen as control.

Detailed description:

Arms:
arm 1: AZD1940 800ug given predose arm 2: Naproxen 500mg given pre-surgery arm 3: Placebo given pre-surgery

Interventions: intervention 1: AZD1940 intervention 2: Naproxen intervention 3: Placebo
Intervention descriptions: intervention 1: 800ug oral administration intervention 2: 500mg oral administration intervention 3: Placebo given pre-surgery

Protocol document: