Conditions: Cerebral Ischemia
Keywords: propofol desflurane cerebrovascular circulation sitting
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 40
Healthy volunteers: no

Brief summary:
The investigators hypothesized that both propofol and desflurane would decrease the regional oxygen saturation (rSO2) but propofol is likely to reduce rSO2 more than sevoflurane when patients are raised to the sitting position.

Detailed description:
The investigators hypothesized that both propofol and desflurane would decrease the rSO2 but propofol is likely to reduce rSO2 more than sevoflurane when patients are raised to the sitting position. Therefore, the purpose of this study was to investigate the effect of desflurane and propofol on rSO2 values during the beach chair position for shoulder arthroscopy.

Arms:
arm 1: anaesthesia was induced with thiopental sodium 2 mg kg-1, alfentanil 10 μg kg-1 and rocuronium 0.6 mg kg-1. Anesthetic maintenance by desflurane arm 2: anaesthesia was induced with the effect-site concentration of propofol 5.0 μg ml-1, alfentanil 10 μg kg-1, and rocuronium 0.6 mg kg-1. A commercially available target controlled infusion (TCI) pump (Orchestra®, Fresenius Vial, France) was used and the pharmacokinetic set used to calculate target effect-site concentrations for propofol was Schnider and colleagues' model

Interventions: intervention 1: propofol intervention 2: Desflurane intervention 3: alfentanil intervention 4: Rocuronium
Intervention descriptions: intervention 1: anaesthesia was induced with the effect-site concentration of propofol 5.0 μg ml-1 mainly. intervention 2: anaesthesia was maintained by desflurane 4-7vol% intervention 3: administration of alfentanil 10 μg kg-1 for anesthetic induction intervention 4: administration of rocuronium 0.6 mg kg-1 for anesthetic induction

Protocol document: