Conditions: Schizophrenia
Keywords: Schizophrenia Atypical antipsychotic Psychosis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 593
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine the safety and efficacy of iloperidone compared to placebo and an active comparator in the treatment of patients with schizophrenia in acute exacerbation.

Detailed description:
Schizophrenia is a severe mental illness affecting an estimated 1% of the world's population. Patients with schizophrenia suffer from productive symptoms (e.g., hallucinations and delusions), and deficit symptoms (e.g., a reduction or absence of normal behaviors or emotions). Other symptoms include a reduced ability to recall and learn new information.

Iloperidone is being development as a treatment for symptoms of schizophrenia. This trial will test the safety and efficacy of iloperidone in patients with an acute exacerbation of the disease.

Arms:
arm 1: Oral iloperidone arm 2: Oral ziprasidone arm 3: Oral placebo

Interventions: intervention 1: Iloperidone intervention 2: Ziprasidone intervention 3: Placebo
Intervention descriptions: intervention 1: None intervention 2: None intervention 3: None

Protocol document: