Conditions: Hypertension
Keywords: hypertension controlled hypertension hypertensives
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 21
Healthy volunteers: no

Brief summary:
The objective of this study is to evaluate the safety, tolerability, and pharmacokinetics of subcutaneous (SC) PL-3994, relative to placebo in subjects with controlled hypertension. Including in this evaluation is the effect PL3994 has on blood pressure.

Detailed description:
Uncontrolled hypertension, including both hypertensive urgency and hypertensive emergency, is commonly seen in emergency rooms and other urgent care settings. Current standards of care include intravenously administered drugs, which can be difficult to titrate and require ongoing monitoring. This study examines the effect of PL-3994 on patients with controlled hypertension who are receiving antihypertensive medications.

Arms:
arm 1: PL3994 Dose A arm 2: PL3994 Dose B arm 3: PL3994 Dose C arm 4: PL3994 Dose D arm 5: PL3994 Dose E arm 6: Placebo

Interventions: intervention 1: PL3994 intervention 2: Placebo
Intervention descriptions: intervention 1: Study drug intervention 2: Placebo

Protocol document: