Conditions: Small Cell Lung Carcinoma
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 485
Healthy volunteers: no

Brief summary:
To compare the effects of irinotecan hydrochloride with cisplatin to the "standard" regimen etoposide plus cisplatin on overall survival, in chemotherapy-naive patients with newly diagnosed Extensive Disease-Small Cell Lung Cancer (ED-SCLC).

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Etoposide + cisplatin intervention 2: Irinotecan + cisplatin
Intervention descriptions: intervention 1: etoposide 100 mg/m2 days 1, 2 and 3 cisplatin 80 mg/m2 day 1 3 week cycle intervention 2: irinotecan 65 mg/m2 day 1 and 8 cisplatin 80mg/m2 day 1 3 week cycle

Protocol document: