Conditions: Psoriasis
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 198
Healthy volunteers: no

Brief summary:
The study evaluated the efficacy of AMG 827 compared with placebo as measured by the percent of improvement in PASI score at week 12.

Detailed description:
The study evaluated the efficacy of AMG 827 compared with placebo as measured by the percent of improvement in PASI score at week 12. Subjects were randomized ina 1:1:1:1:1 ratio. Subjects randomized to receive AMG 827 received 70, 140, or 210 mg at day 1 and weeks 4 and 8.

Arms:
arm 1: 140 mg SC arm 2: 70 mg SC arm 3: 280 mg SC arm 4: 210 mg SC arm 5: Placebo

Interventions: intervention 1: 70 mg SC intervention 2: 210 mg SC intervention 3: 140 mg SC intervention 4: 280 mg SC intervention 5: Placebo
Intervention descriptions: intervention 1: 70 mg SC intervention 2: 210 mg SC intervention 3: 140 mg SC intervention 4: 280 mg SC intervention 5: Placebo SC

Protocol document: