Conditions: Hypertension
Keywords: Hypertension
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 16
Healthy volunteers: no

Brief summary:
This is a randomized, double-blind, placebo-controlled study. The hypothesis for this study is that single oral doses of MK-8266 selected for this study are sufficiently safe and well tolerated by elderly male and elderly female participants with hypertension to permit continued clinical investigation.

Detailed description:
Two panels, each consisting of eight participants (8 elderly males with mild to moderate hypertension in Panel A and 8 elderly females with mild to moderate hypertension in Panel B) will be randomized to receive either MK-8266 or matching placebo in a 3:1 ratio. Participants will receive single doses of MK-8266 or matching placebo in three treatment periods (Periods 1 through 3). In both Panel A and Panel B, doses will escalate in a rising, fixed sequence. In Period 1 (0.3 mg), Period 2 (0.6 mg), and Period 3 (0.7 mg and then 0.3 mg 10 hours later) once daily doses of MK-8266 or matching placebo will be administered.

All participants will receive at least 2 doses of MK-8266. Participants completing placebo treatment in Period 1 will flow to the MK-8266 arm in the next period, with 2 participants from the MK-8266 arm receiving placebo in the next period.

Blood samples will be obtained pre-dose and at selected time points up to 48 hours post-dose for determination of MK-8266 plasma concentrations.

Arms:
arm 1: MK-8266 single dose 0.3 mg arm 2: MK-8266 single dose 0.6 mg arm 3: MK-8266 single dose 0.7 mg and then 0.3 mg after 10 hours arm 4: Placebo to MK-8266 single dose arm 5: MK-8266 single dose 0.3 mg arm 6: MK-8266 single dose 0.6 mg arm 7: MK-8266 single dose 0.7 mg and then 0.3 mg after 10 hours arm 8: Placebo to MK-8266 single dose

Interventions: intervention 1: MK-8266 intervention 2: Placebo
Intervention descriptions: intervention 1: Oral capsules, 0.1 mg potency intervention 2: Oral placebo capsules to match MK-8266 capsules

Protocol document: