Conditions: Neoplasms
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 34
Healthy volunteers: no

Brief summary:
This is a dose-finding study; therefore, there is no hypothesis testing

Detailed description:

Arms:
arm 1: Schedule A (CP-870,893 administration schedule) arm 2: Schedule B (CP-870,893 administration schedule)

Interventions: intervention 1: Paclitaxel + Carboplatin + CP-870,893 intervention 2: Paclitaxel + Carboplatin + CP-870,893
Intervention descriptions: intervention 1: Paclitaxel is administered intravenously on day 1 of a 21-day cycle at a dose of 175 mg/m\^2. Carboplatin is administered intravenously on day 1 of a 21-day cycle at AUC 6. CP-870,893 is administered intravenously on DAY 3 of a 21-day cycle in escalating doses (0.1 mg/kg and 0.2 mg/kg) intervention 2: Paclitaxel is administered intravenously on day 1 of a 21-day cycle at a dose of 175 mg/m\^2. Carboplatin is administered intravenously on day 1 of a 21-day cycle at AUC 6. CP-870,893 is administered intravenously on DAY 8 of a 21-day cycle in escalating doses (0.1 mg/kg and 0.2 mg/kg)

Protocol document: