Conditions: Heartburn
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 24
Healthy volunteers: yes

Brief summary:
A study in 24 healthy subjects to assess the bioequivalence of Famotidine/Antacid EZ Chew tablet taken without water and with water compared to the Famotidine/Antacid tablet taken with water. Subjects will be given a single dose of each treatment separated by 5 to 7 days.

Detailed description:

Arms:
arm 1: Famotidine/antacid combination tablet with water arm 2: Famotidine/Antacid EZ Chew tablet without water arm 3: Famotidine/Antacid EZ Chew tablet with water

Interventions: intervention 1: famotidine (+) calcium carbonate (+) magnesium hydroxide tablet intervention 2: Comparator: famotidine (+) calcium carbonate (+) magnesium hydroxide EZ Chew tablet without water intervention 3: Comparator: famotidine (+) calcium carbonate (+) magnesium hydroxide EZ Chew tablet with water
Intervention descriptions: intervention 1: A single dose of famotidine/antacid tablet with 120 mL of water in one of three treatment periods intervention 2: A single dose of famotidine/antacid combination EZ Chew tablet without water in one of three treatment periods intervention 3: A single dose of famotidine/antacid combination EZ Chew tablet with 120 mL of water in one of three treatment periods

Protocol document: