Conditions: Asthma
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 16
Healthy volunteers: no

Brief summary:
This study will assess the Early Airway Response (EAR) associated change in forced expiratory volume in one second (FEV1) and plasma 9α-11ß-PGF2 ('9P') after single dose pretreatment of nedocromil, montelukast, and mometasone.

Detailed description:

Arms:
arm 1: Placebo arm 2: Montelukast arm 3: Nedocromil arm 4: Mometasone

Interventions: intervention 1: Nedocromil intervention 2: Comparator: Montelukast intervention 3: Comparator: Mometasone intervention 4: Placebo
Intervention descriptions: intervention 1: Nedocromil 4 mg, as metered dose inhaler 1 hour prior to allergen challenge intervention 2: Montelukast single 10 mg tablet administered 2 hours prior to allergen challenge intervention 3: Mometasone furoate 400 mcg by twisthaler, administered 2 hours prior to allergen challenge intervention 4: Mometasone placebo twisthaler, Nedocromil placebo metered dose inhaler, Montelukast placebo tablet

Protocol document: