Conditions: Postoperative Pain
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 277
Healthy volunteers: no

Brief summary:
This study will compare repeated intermittent IV dosing of diclofenac in patient with moderate to severe post-surgical pain from elective orthopedic surgery.

Detailed description:
The primary objective is to evaluate the analgesic efficacy and safety of three dosage levels of parenteral diclofenac in providing pain relief as compared to placebo or Ketorolac tromethamine.

Arms:
arm 1: DIC075V (IV diclofenac) arm 2: IV Ketorolac arm 3: Placebo

Interventions: intervention 1: IV Diclofenac intervention 2: IV ketorolac intervention 3: Placebo
Intervention descriptions: intervention 1: IV Diclofenac q6h intervention 2: IV ketorolac q6h intervention 3: Placebo q6h

Protocol document: