Conditions: Schizophrenia and Predominant Negative Symptoms
Keywords: Schizophrenia
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 92
Healthy volunteers: no

Brief summary:
To explore the efficacy of SPD489, as adjunctive therapy to a stable dose of atypical antipsychotic medication, on negative symptoms in adult subjects with clinically stable schizophrenia and predominant negative symptoms, as measured by the Scale for the Assessment of Negative Symptoms (SANS).

Detailed description:

Arms:
arm 1: None arm 2: Placebo

Interventions: intervention 1: SPD489 (lisdexamfetamine dimesylate) intervention 2: Placebo matching SPD489 (lisdexamfetamine dimesylate)
Intervention descriptions: intervention 1: oral, 20, 30, 40, 50, 60, or 70 mg once daily intervention 2: oral, once daily

Protocol document: