Conditions: Chronic Pain
Keywords: OA Chronic Pain Osteoarthritis OA Pain Osteoarthritis Pain Pain Hip Pain Knee Pain Joint Pain
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 343
Healthy volunteers: no

Brief summary:
To evaluate the efficacy of OROS Hydromorphone in reducing moderate to severe chronic pain in patients with Osteoarthritis (OA) Pain

Detailed description:

Arms:
arm 1: OROS hydromorphone tablets administered orally once daily in total daily doses of 12, 16, 24, 32, 40, 48, or 64 mg arm 2: Matching placebo tablets orally once daily (number and dosage of tablets to match the number and dosage of the stable dose of OROS hydromorphone obtained in the Conversion and Titration phase).

Interventions: intervention 1: OROS hydromorphone intervention 2: Placebo
Intervention descriptions: intervention 1: hydromorphone 12, 16, 24, 32, 40, 48, or 64 mg tablets intervention 2: Placebo

Protocol document: