Conditions: Type 2 Diabetes Hypertension
Keywords: blood pressure reduction
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 207
Healthy volunteers: no

Brief summary:
To determine if olmesartan plus amlodipine combination therapy alone and with hydrochlorothiazide will be safe and effective to reduce high blood pressure in hypertensive, type 2 diabetic subjects.

Detailed description:
This is a single group study in which participants were titrated to the next of 6 regimens if blood pressure (BP) goals were not met.

Arms:
arm 1: amlodipine; and olmesartan medoxomil, if required; and hydrochlorothiazide, if required.

Interventions: intervention 1: Amlodipine intervention 2: amlodipine / olmesartan medoxomil combination intervention 3: Hydrochlorothiazide
Intervention descriptions: intervention 1: Amlodipine 5 mg tablets , Daily for 3 weeks; intervention 2: amlodipine / olmesartan medoxomil combination tablets 5 mg/20 mg or 5 mg/40 mg or 10 mg/40 mg intervention 3: hydrochlorothiazide tablets, 12.5 mg or 25 mg.

Protocol document: