Conditions: Healthy
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 29
Healthy volunteers: yes

Brief summary:
Obtain interaction data between BI 201335 and Efavirenz to guide dosing for each drug when administered together.

To predict drug interaction between BI 201335 and Cyp 3A4 y using Midazolam as cyp 3A4 probe , Efavirenz as enzyme inducer and BI 201335 as enzyme inhibitor.

Detailed description:

Arms:
arm 1: low dose Efavirenz arm 2: normal dose Efavirenz

Interventions: intervention 1: low dose intervention 2: normal dose intervention 3: low dose
Intervention descriptions: intervention 1: efavirenz single dosing once daily intervention 2: efavirenz once daily intervention 3: Efavirenz single dosing once daily

Protocol document: