Conditions: Sleep Deprivation
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 135
Healthy volunteers: yes

Brief summary:
This is a double-blind, single center, parallel group, placebo and active comparator, controlled study to characterize the wake promoting effects of single doses of SPD489 in healthy adult male undergoing acute sleep deprivation.

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None arm 4: None arm 5: None

Interventions: intervention 1: SPD489 20 mg intervention 2: SPD489 50 mg intervention 3: SPD489 70 mg intervention 4: Armodafinil intervention 5: Placebo
Intervention descriptions: intervention 1: Single oral dose of 20 mg intervention 2: Single oral dose of 50 mg intervention 3: Single oral dose of 70 mg intervention 4: Single oral dose of 250 mg intervention 5: Single oral dose

Protocol document: