Conditions: Coronary Artery Disease (CAD)
Keywords: Clopidogrel VerifyNow PRU Measurements Drug Eluting Stents (DES) Heart Disease Percutaneous Coronary Intervention (PCI) P2Y12 Platelets Platelet Reactivity
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 423
Healthy volunteers: no

Brief summary:
To determine the efficacy of prasugrel versus clopidogrel for the reduction of adverse cardiovascular outcomes in patients with high platelet reactivity on clopidogrel after successful implantation of coronary drug-eluting stents.

To determine the adverse event profile of prasugrel in patients with high platelet reactivity on clopidogrel after implantation of coronary drug-eluting stents.

To determine the effect of prasugrel on inhibition of platelet activation in patients with high platelet reactivity on clopidogrel.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Prasugrel intervention 2: Clopidogrel
Intervention descriptions: intervention 1: One time 60 milligram (mg) oral loading dose and 10 mg once daily oral maintenance dose up to 6 months. intervention 2: 75 mg oral daily maintenance dose up to 6 months.

Protocol document: