Conditions: Major Depressive Disorder
Keywords: depression
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 28
Healthy volunteers: yes

Brief summary:
The main purpose of this study is to evaluate the effect of desvenlafaxine administered as DVS SR on the pharmacokinetics of midazolam in healthy male and female subjects. The amount of drug in the body and the effect of the drug will also be evaluated.

Detailed description:

Arms:
arm 1: None

Interventions: intervention 1: Desvenlafaxine Succinate Sustained Release intervention 2: Midazolam
Intervention descriptions: intervention 1: 50 mg DVS SR tablet days 1-6, period 2 only. intervention 2: 4 mg midazolam (2 mL midazolam syrup) day 1, period 1 and day 6, period 2.

Protocol document: