Conditions: Falciparum Malaria
Keywords: Plasmodium infections Remittent fever Artemether Artemisinins quinine Malaria Protozoan Infections Anti-Infective Agents Antiprotozoal Agents Schistosomicides Pharmacologic Actions Malaria, Falciparum Antimalarials Antiparasitic Agents Parasitic Diseases sublingual
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 31
Healthy volunteers: no

Brief summary:
The purpose of this study is to compare the efficacy of Artemether Sublingual Spray (ArTiMist™) with intravenous quinine in children with severe or complicated falciparum malaria, or children with uncomplicated malaria with gastrointestinal complications.

Detailed description:

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Quinine intervention 2: Artemether
Intervention descriptions: intervention 1: 20 mg/kg intravenous quinine loading dose, followed by 10 mg/kg intravenously every 8 hours until resumption of normal oral therapy intervention 2: Artemether sublingual spray 3 mg/kg at protocol specified timepoints until resumption of normal oral therapy

Protocol document: