Conditions: Asthma
Keywords: Asthma hyperresponsiveness
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 10
Healthy volunteers: no

Brief summary:
The purpose of this study is to confirm previous observations in asthmatics that chronic nadolol treatment reduces asthmatic airway hyper-responsiveness.

Detailed description:

Arms:
arm 1: Dose escalation through 1.25mgs, 2.5mgs, 5.0mgs, 10mgs, 20mgs, and 40mgs of nadolol at 2 week intervals as tolerated.

Interventions: intervention 1: nadolol
Intervention descriptions: intervention 1: Nadolol, oral taken daily, doses will be escalated every two weeks over 13 weeks following a 2 week run-in.

Protocol document: