Conditions: Hypertension
Keywords: Hypertension African Americans Aliskiren Amlodipine Systolic blood pressure Diastolic blood pressure Stage II Combination
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 443
Healthy volunteers: no

Brief summary:
The purpose of the study is to evaluate the BP-lowering efficacy of the combination of aliskiren and amlodipine, as initial therapy, compared to amlodipine monotherapy in African American patients with Stage II hypertension.

Detailed description:

Arms:
arm 1: Aliskiren/Amlodipine 150 mg/5 mg titrated to 300 mg/10 mg arm 2: Amlodipine 5mg titrated to 10 mg

Interventions: intervention 1: Aliskiren/Amlodipine intervention 2: Amlodipine
Intervention descriptions: intervention 1: Aliskiren/Amlodipine 150 mg/5 mg titrated to 300 mg/10 mg intervention 2: Amlodipine 5 mg titrated to 10mg

Protocol document: