Conditions: Pharmacodynamic
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 6
Healthy volunteers: yes

Brief summary:
In this study the investigators will test a nutritional supplement called betaine hydrochloride to see if it can temporarily increase the stomach acid in healthy volunteers who have decreased stomach acid because they take a medicine called rabeprazole.

Detailed description:
Investigators will evaluate the extent and time course of gastric re-acidification after oral betaine HCl in healthy volunteers with pharmacologically-induced hypochlorhydria. After betaine HCl dose, gastric pH will be continuously monitored for 2 hours.

Arms:
arm 1: None

Interventions: intervention 1: betaine hydrochloride intervention 2: Rabeprazole
Intervention descriptions: intervention 1: betaine hydrochloride 1500mg po x 1 on day 5 intervention 2: rabeprazole po daily x 5 days

Protocol document: