Conditions: Pain Osteoarthritis, Knee
Allocation: NON_RANDOMIZED | Intervention model: PARALLEL
Enrollment: 238
Healthy volunteers: no

Brief summary:
The purpose of this study is to evaluate the long-term safety (up to one year) of Tramadol Once-A-Day (OAD) tablets at the highest doses: 200-400 mg

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None arm 4: Despite provision in the protocol that the minimum daily dose was 200 mg, 2 patients took 100 mg against instructions.

Interventions: intervention 1: Tramadol OAD intervention 2: Tramadol OAD intervention 3: Tramadol OAD intervention 4: Tramadol OAD 100mg
Intervention descriptions: intervention 1: None intervention 2: None intervention 3: None intervention 4: None

Protocol document: