Conditions: Smoking Cessation
Keywords: nicotine lozenge nicotine nicotine replacement therapy
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 50
Healthy volunteers: yes

Brief summary:
To compare the bio equivalence of new nicotine lozenge formulation with the reference nicotine lozenge so as to deliver the same nicotine blood profile.

Detailed description:

Arms:
arm 1: 2 mg test nicotine lozenge to be chewed. arm 2: 4 mg test nicotine lozenge to be chewed. arm 3: 2 mg reference nicotine lozenge to be chewed. arm 4: 4 mg reference nicotine lozenge to be chewed.

Interventions: intervention 1: Nicotine (2 mg) intervention 2: Nicotine (4 mg)
Intervention descriptions: intervention 1: 2 mg nicotine lozenge in two formulations intervention 2: 4 mg nicotine lozenge in two formulations

Protocol document: