Conditions: Alcohol Withdrawal
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 102
Healthy volunteers: no

Brief summary:
Intravenous phenobarbital in combination with a symptom-guided standardized lorazepam-based alcohol withdrawal protocol will be associated with decreased need for ICU admission, continuous lorazepam infusion and will not be associated with increased adverse events.

Detailed description:

Arms:
arm 1: 10 mg/kg IV phenobarbital in 100 ml saline arm 2: 100 ml saline

Interventions: intervention 1: 10 mg/kg IV phenobarbital in 100 ml saline intervention 2: placebo
Intervention descriptions: intervention 1: 10 mg/kg IV phenobarbital in 100 ml saline intervention 2: 100 m l saline

Protocol document: