Conditions: Marijuana Abuse
Keywords: cannabis dependence dronabinol treatment
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 156
Healthy volunteers: yes

Brief summary:
The purpose of this study is to determine if dronabinol decreases the symptoms of marijuana addiction and withdrawal.

Detailed description:
Marijuana addiction is associated with significant withdrawal symptoms, including anxiety, irritability, bodily discomfort, and insomnia. The purpose of this study is to determine the effectiveness of dronabinol in reducing withdrawal symptoms.

During this twelve-week, double-blind, placebo-controlled study, study visits will occur twice each week. During study visits, participants will receive either placebo or medication. Throughout the study, all participants will receive individualized psychotherapy sessions. At each study visit, vital signs, self-report ratings, and urine samples will be collected. Participants will have a follow-up evaluation at month 6.

Arms:
arm 1: Dronabinol: 20mg bid for a daily maximum dose of 40mg. arm 2: placebo

Interventions: intervention 1: Dronabinol intervention 2: Placebo
Intervention descriptions: intervention 1: Dronabinol intervention 2: placebo

Protocol document: