Conditions: Carotid Stenosis
Keywords: Patients scheduled for elective carotid endarterectomy
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 2
Healthy volunteers: no

Brief summary:
To evaluate the causal relationship between Rho/Rho kinase overactivity and mechanisms of vascular dysfunction in patients with atherosclerosis.

Detailed description:

Arms:
arm 1: Fasudil hydrochloride 40 mg three times a day X 14 days arm 2: Placebo 1 tablet three times daily x 14 days

Interventions: intervention 1: Fasudil Hydrochloride intervention 2: Placebo Oral Tablet
Intervention descriptions: intervention 1: Fasudil 40 mg three times a day x 14 days intervention 2: Placebo oral tablet manufactured to mimic fasudil three times a day x 14 days

Protocol document: