Conditions: Hypertension
Keywords: Children pediatrics High Blood Pressure Hypertension Valsartan enalapril
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 300
Healthy volunteers: no

Brief summary:
The purpose of this 12-week active controlled trial is to evaluate the safety and efficacy of valsartan 80/160/320 mg (weight stratified) compared with enalapril 10/20/40 mg (weight stratified) on sitting systolic blood pressure (SSBP) in 6 - 17 year old children with hypertension (SSBP ≥ 95th percentile for age gender and height).

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None arm 4: None arm 5: None arm 6: None

Interventions: intervention 1: Valsartan intervention 2: Enalapril
Intervention descriptions: intervention 1: Weight stratified dosages given by mouth, once daily, of valsartan 80/160/320 mg. intervention 2: Weight stratified dosages given by mouth, once daily, of enalapril 10/20/40 mg.

Protocol document: