Conditions: Smoking Cessation
Keywords: smoking cessation varenicline elective surgery wound infections post-operative complications
Allocation: NON_RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 16
Healthy volunteers: no

Brief summary:
It is possible to offer smoking cessation treatment including varenicline to patients scheduled for elective surgery. This study will evaluate whether or not this will enable some patients to quit smoking for up to 4 weeks prior to surgery and in turn, whether this may lead to reductions in post-operative complication such as wound infections.

Detailed description:
Recruitment to this study was terminated (on February 23, 2010) earlier than originally planned because recruitment was much slower than expected and therefore the study has already achieved its main objective of assessing the feasibility of conducting a larger study of similar design to investigate the efficacy of smoking cessation therapy in a pre-surgical setting. The decision to end recruitment to the trial was not based on any safety concerns.

Arms:
arm 1: None

Interventions: intervention 1: Varenicline
Intervention descriptions: intervention 1: Varenicline film coated tablets - escalating dose with maximum dose of 1mg bd

Protocol document: