Conditions: Irritable Colon
Keywords: TRPV1 antagonist Fecal Urgency rectal pain IBS
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 1
Healthy volunteers: no

Brief summary:
SB-705498 has demonstrated efficacy in several preclinical and human experimental pain models. This study will investigate the efficacy of SB-705498 in patients with rectal pain. This will be a double-blind, placebo-controlled, two-way crossover study. 21 patients with faecal urgency (Group 1), and 21 patients with IBS (Group 2) will complete this study.

Detailed description:

Arms:

Interventions: intervention 1: SB-705498
Intervention descriptions: intervention 1: None

Protocol document: