Conditions: Laryngopharyngeal Reflux
Keywords: Gastroesophageal reflux Laryngitis Hoarseness Dysphonia Proton pump inhibitor
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 18
Healthy volunteers: no

Brief summary:
The purpose of this study is to determine whether Lansoprazole 30mg taken twice daily is effective in the treatment of laryngitis due to gastroesophageal reflux.

Detailed description:
The investigators propose to study the effect of Lansoprazole 30 mg bid therapy vs. placebo in patients who present with symptoms characteristic of reflux laryngitis. The efficacy of Lansoprazole 30 mg bid in healing and improving reflux laryngitis will be determined. For the purpose of this study, healed reflux laryngitis will be defined as an improvement or resolution of arytenoid erythema and improvement in symptoms. Improved reflux laryngitis will be defined as improvement in any two of the following areas: arytenoid erythema; voice quality as assessed by the patients or health care provider; or, improvement/resolution of related symptoms (throat clearing, cough, etc.). The impact of Lansoprazole 30 mg bid therapy on quality of life will be evaluated in a preliminary fashion.

Arms:
arm 1: Lansoprazole 30 mg Twice Daily arm 2: placebo

Interventions: intervention 1: Lansoprazole intervention 2: Sugar pill
Intervention descriptions: intervention 1: Lansoprazole 30mg twice daily intervention 2: placebo twice daily

Protocol document: