Conditions: Osteoporosis
Keywords: Osteoporosis Post-menopausal Bone mineral density
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 110
Healthy volunteers: no

Brief summary:
This study will compare the effects of Zoledronic acid and Raloxifene in reducing bone turnover markers in postmenopausal women with low bone mineral density over 6 months.

Detailed description:

Arms:
arm 1: Zoledronic acid 5 mg (single i.v. infusion) + daily oral placebo for 6 months (zoledronic acid group) arm 2: Placebo (single i.v. infusion) + oral raloxifene 60 mg/day for 6 months (raloxifene group)

Interventions: intervention 1: Raloxifene intervention 2: Zoledronic acid intervention 3: Placebo oral pills intervention 4: Placebo intravenous (i.v.) infusion
Intervention descriptions: intervention 1: None intervention 2: None intervention 3: None intervention 4: None

Protocol document: