Conditions: Infections, Gram-positive Bacterial
Keywords: Abscess Burns Cellulitis Ulcer Wound infections
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 201
Healthy volunteers: no

Brief summary:
Serious infections caused by resistant bacteria are becoming more of a medical problem throughout the world. This study will measure how well TD-6424 (Telavancin) can control infections and whether the drug is safe to give to patients.

Detailed description:

Arms:
arm 1: None arm 2: cSSSI - comlicated skin and skin structure infections

Interventions: intervention 1: Telavancin intervention 2: vancomycin or antistaphylococcal penicillin
Intervention descriptions: intervention 1: Telavancin 7.5 mg/kg/day, amended to 10 mg/kg/day, IV (intravenously) for up to 14 days intervention 2: Vancomycin 1 Gram IV (intravenously) every 12 hrs or nafcillin 2 Grams, oxacillin 2 Grams, or (in South Africa) cloxacillin 0.5 - 1 Gram, IV (intravenously) every 6 hrs for up to 14 days.

Protocol document: