Conditions: Psoriasis Vulgaris
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 458
Healthy volunteers: no

Brief summary:
This study will compare efficacy and safety of once daily treatment of calcipotriol plus betamethasone dipropionate gel (LEO 80185) with tacalcitol ointment and LEO 80185 vehicle alone in subjects with psoriasis vulgaris. Subjects will be treated for up to 8 weeks followed by an observation period of up to 8 weeks to investigate the occurence and the time to relapse and occurence of rebound after discontinuation of the investigational products. Only subjects with "controlled disease" will be considered for this observation phase of the study. "Controlled disease" is defined as "Clear" or "Almost Clear" severity category based on Investigator's global assessment (IGA).

Detailed description:

Arms:
arm 1: None arm 2: None arm 3: None

Interventions: intervention 1: calcipotriol and betamethasone (LEO 80185 gel) intervention 2: LEO 80185 vehicle intervention 3: Tacalcitol ointment
Intervention descriptions: intervention 1: Once daily application intervention 2: Once daily application intervention 3: Once daily application

Protocol document: