Conditions: Critically Ill Hypoglycemia
Keywords: Intensive insulin therapy (IIT) Insulin infusion Tight glycemic control Intensive Care Units
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 19
Healthy volunteers: no

Brief summary:
The goal of this present proposal is to examine the efficacy of GLP-1 administered to control blood glucose in critically ill patients.

Detailed description:
All patients whom on admission to the ICU (surgical, burn, \& cardiac) who are expected to receive intensive insulin therapy for at least 72 hours are eligible to be enrolled. Once enrolled, the patients will be randomized to one of two groups: the experimental (intravenous GLP-1 infusion for 72 hours) or control groups (intravenous 0.9% sodium chloride (NaCl) infusion for 72 hours) in a double masked fashion. While enrolled, all patients will receive standard-of-care insulin therapy. Both groups will be maintained on the standard ICU specific protocol for glucose control.

Arms:
arm 1: None arm 2: None

Interventions: intervention 1: Glucagon-Like Peptide-1 intervention 2: Saline
Intervention descriptions: intervention 1: 5ng/kg-1/min-1 GLP-1 infused in 3 ml continuously over 72 hours. intervention 2: 5ng/kg-1/min-1 placebo infused in 3 ml continuously over 72 hours.

Protocol document: