Conditions: Hyperglycemia Hematopoietic Stem Cell Transplantation
Keywords: Hyperglycemia Hematopoietic stem cell transplantation Bone marrow transplant High blood sugar
Allocation: RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 11
Healthy volunteers: no

Brief summary:
To determine whether intensive glucose control results in improved mortality and reduced hospital stay length by performing a randomized trial of intensive glucose management (blood glucose goal 110 mg/dl) using continuous IV insulin and glucose vs. non-intensive glucose management (goal 200 mg/dl)

Detailed description:
TO determine whether there are fewer infections, days without a fever, days on antibiotics given for an infection and time to marrow engraftment are improved by intensive glucose management; and to determine whether there is evidence of a reduction in measures of inflammation in patients randomized to intensive glucose management and whether reduction of inflammation is associated with outcome.

Arms:
arm 1: Regular Sliding Scale Insulin administration for hyperglycemia arm 2: MiniMed Paradigm monitoring device for hyperglycemia

Interventions: intervention 1: Regular Insulin intervention 2: Deployment of the MiniMed Paradigm monitoring device
Intervention descriptions: intervention 1: Use of sliding scale insulin as per Appendix 1 intervention 2: Automated insulin delivery system

Protocol document: