Conditions: Bipolar Depression
Keywords: inpatient bipolar depression quetiapine Seroquel IR Seroquel XR safety tolerability
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 139
Healthy volunteers: no

Brief summary:
The purpose of the study is to compare the sedation profile one hour after dose administration between Seroquel IR and Seroquel XR.

Detailed description:

Arms:
arm 1: Quetiapine 25, 100, 200 and 300 mg arm 2: Quetiapine 50, 200, 300

Interventions: intervention 1: Quetiapine Immediate Release intervention 2: Quetiapine Extended Release
Intervention descriptions: intervention 1: Oral, 3 tablets daily: (2 x 25 mg + 1 x 50 mg) at one time each day intervention 2: Oral, 3 tablets daily: (2 x 25 mg + 1 x 50 mg) at one time each day

Protocol document: