Conditions: Coronary Artery Disease Asthma Chronic Obstructive Pulmonary Disease (COPD) Angina
Keywords: Coronary Artery Disease Coronary Vessels Myocardial Ischemia Coronary Disease Ischemic heart disease asthma copd
Allocation: RANDOMIZED | Intervention model: CROSSOVER
Enrollment: 14
Healthy volunteers: no

Brief summary:
The goal of this research is to determine the utility of Regadenoson (Lexiscan)for use as an imaging agent with cardiac MR. If found useful, it will help us establish a protocol for regadenoson stress MR perfusion (Regadenoson stress test with cardiac MR).The investigators will compare regadenoson with dobutamine so each participant will undergo two studies. A cardiac MR stress test with regadenoson and with dobutamine. The investigators participants will include patients with history of COPD and Asthma, so it will also help us determine feasibility of Regadenoson in these patient's subgroups.

Detailed description:

Arms:
arm 1: Arm A will get Dobutamine Stress test with cardiac MR (CMR). Both arms will then cross over to the other arm to get the second test. So each participant will undergo two types of testing. arm 2: Arm B will get Regadenoson stress test with CMR. Both arms will then cross over to the other arm to get the second test. So each participant will undergo two types of testing.

Interventions: intervention 1: Regadenoson intervention 2: Dobutamine
Intervention descriptions: intervention 1: Each participant will receive regadenoson 0.4mg (5ml) one time bolus dose at one visit. intervention 2: Each participant will receive dobutamine infusion (as per protocol to achieve a target heart rate of 85% of predicted for age) at another visit.

Protocol document: