Conditions: Atopic Dermatitis
Allocation: RANDOMIZED | Intervention model: SINGLE_GROUP
Enrollment: 26
Healthy volunteers: no

Brief summary:
The purpose of this research study is to better understand adherence to Locoid when people use it to treat atopic dermatitis.

Detailed description:
An investigator-blinded prospective study of subjects with mild to moderate atopic dermatitis (\>5% Body Surface area and 2 or 3 on the Investigator Global Assessment (IGA) scale). The drug will be used within FDA-approved labeling. Subjects will be randomized to each of the following topical hydrocortisone 17-butyrate 0.1% preparations- ointment, cream or lipocream- in the manufacturer's original tube fitted with a Medication Event Monitoring System (MEMS) cap. This cap records dates and times the assembly is opened and this data can be downloaded and tabulated with the associated software.

The study will consist of a 2-week Treatment Phase (visits at Baseline and Week 2). Subjects will be instructed to apply the medication twice daily (morning and evening) for 2 weeks to all of their AD lesions.

Adherence will be measured by MEMs cap.

Arms:
arm 1: topical hydrocortisone 17-butyrate 0.1% Cream preparation applied twice daily to all lesions of atopic dermatitis arm 2: topical hydrocortisone 17-butyrate 0.1% Ointment preparation applied twice daily to all lesions of atopic dermatitis arm 3: topical hydrocortisone 17-butyrate 0.1% Lipocream preparation applied twice daily to all lesions of atopic dermatitis

Interventions: intervention 1: hydrocortisone 17-butyrate 0.1% Cream preparation intervention 2: hydrocortisone 17-butyrate 0.1% Ointment preparation intervention 3: hydrocortisone 17-butyrate 0.1% Lipocream preparation
Intervention descriptions: intervention 1: Apply medication twice a day to affected areas of atopic dermatitis intervention 2: Apply medication twice a day to affected areas of atopic dermatitis intervention 3: Apply medication twice a day to affected areas of atopic dermatitis

Protocol document: