Conditions: Large Polyps in the Gastrointestinal Tract
Keywords: submucosal cushion polypectomy endoscopic mucosal resection
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 18
Healthy volunteers: yes

Brief summary:
For removal of large flat lesions of the gastro-intestinal tract injection of a solution under the lesion creates a "safety" cushion and protects from damage to the gastrointestinal tract wall. Various solutions are currently used, but some of them are easy to inject but quickly dissipate (normal saline),other solutions are more longer lasting (hydroxypropyl methylcellulose, hyaluronic acid, etc) but are very difficult to inject and can be expensive and not always available. The investigators performed previously animal experiments which demonstrated that blood is easy to inject and creates a protective cushion which lasts longer than other fluids which are currently used for protective cushion creation.

Detailed description:
For removal of large flat lesions of the gastro-intestinal tract injection of a solution under the lesion creates a "safety" cushion and protects from damage to the gastrointestinal tract wall. Various solutions are currently used, but some of them are easy to inject but quickly dissipate (normal saline),other solutions are more longer lasting (hydroxypropyl methylcellulose, hyaluronic acid, etc) but are very difficult to inject and can be expensive and not always available. The investigators decided to use blood drawn from the patient for injection under the lesion. The investigators performed previously animal experiments which demonstrated that blood is easy to inject and creates a protective cushion which lasts longer than other fluids which are currently used for protective cushion creation. Blood can also have local hemostatic action preventing from bleeding during polypectomy.

Arms:
arm 1: Polypectomy with normal saline injected for submucosal cushion creation arm 2: Polypectomy after injection of hydroxypropyl methylcellulose (HPMC) to create submucosal cushion arm 3: Polypectomy after injection of autologous blood

Interventions: intervention 1: Autologous blood injection intervention 2: Normal saline intervention 3: HPMC
Intervention descriptions: intervention 1: Autologous blood will be drawn from the patient and then reinjected under the lesion to create a safety cushion intervention 2: Normal saline will be injected under the lesion to create submucosal cushion intervention 3: Hydroxypropyl methylcellulose (HPMC) will be injected under the lesion to create submucosal cushion

Protocol document: