Conditions: Vasoplegic Syndrome Liver Transplant; Complications
Keywords: hydroxocobalamin methylene blue
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 19
Healthy volunteers: no

Brief summary:
This study will evaluate if Hydroxocobalamin may be a new and possibly superior treatment for refractory vasoplegic syndrome during liver transplant surgery.

Detailed description:

Arms:
arm 1: Single dose intraoperatively of Hydroxocobalamin (Cyanokit): 5g IV infusion over 15 minutes arm 2: Single dose intraoperatively of Methylene blue (PROVAYBLUETM), 2 mg/kg IV bolus administered over 15 minutes

Interventions: intervention 1: Hydroxocobalamin intervention 2: Methylene Blue
Intervention descriptions: intervention 1: Hydroxocobalamin (Cyanokit): 5g IV infusion over 15 minutes intervention 2: Methylene blue (PROVAYBLUETM), 2 mg/kg IV bolus administered over 15 minutes

Protocol document:
Prot_SAP_000.pdf: 
 
 
The Efficacy of Intravenous Hydroxocobalamin 
Versus Methylene Blue as Treatment for 
Intraoperative Vasoplegic Syndrome in Liver 
Transplant Patients 
 
NCT04054999 
 
11DEC2019