Conditions: Inflammation Cardiovascular Diseases Zinc Deficiency
Keywords: Zinc inflammation Cardiovascular Diseases risk
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 95
Healthy volunteers: no

Brief summary:
To study the effect of short-term zinc supplementation on improving inflammation, metabolic, and cardiovascular risk among HIV infected patients on stable anti-retroviral therapy

Detailed description:
This study will focus on subjects with documented zinc deficiency (levels \<75 µg/dl) as group most likely to benefit from the zinc supplementation. The investigators also acknowledge that zinc may be beneficial in all HIV subjects, regardless of the plasma zinc level; however initial studies should be done in subjects with low zinc levels as they are more likely to benefit.

Arms:
arm 1: Patients received Zinc gluconate 45 mg capsules orally twice daily for 24 weeks. arm 2: Patients received Zinc gluconate Placebo capsules orally twice daily for 24 weeks.

Interventions: intervention 1: Zinc Gluconate intervention 2: Placebo
Intervention descriptions: intervention 1: Two 45 mg capsules once daily intervention 2: Two placebo capsules once daily

Protocol document:
Prot_SAP_000.pdf: 













































ICF_001.pdf: