Conditions: Chronic Sinusitis Chronic Rhinosinusitis (Diagnosis)
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 196
Healthy volunteers: no

Brief summary:
Multicenter, phase III, randomized, blinded, controlled, parallel group with safety extension phase with crossover or continued treatment.

Detailed description:
This is a 52-week, multicenter, phase III, randomized, blinded, controlled, parallel group with a 24-week treatment period followed by a safety extension phase with crossover or continued treatment to evaluate the efficacy and safety of LYR-210 compared with sham control for treatment in adults with CRS.

Arms:
arm 1: Single administration of LYR-210 drug matrix (7500 μg) arm 2: Single mock administration procedure

Interventions: intervention 1: LYR-210 intervention 2: Sham procedure control intervention 3: Background Therapy
Intervention descriptions: intervention 1: LYR-210 drug matrix (mometasone furoate) intervention 2: Sham procedure control intervention 3: Daily Saline Irrigation

Protocol document:
Prot_000.pdf: 



















































































































































SAP_001.pdf: