Conditions: Latent Tuberculosis Infection
Keywords: TB tuberculosis diagnosis TB screening
Allocation: NA | Intervention model: SINGLE_GROUP
Enrollment: 2017
Healthy volunteers: yes

Brief summary:
The overall objective of this study is to assess the feasibility and potential impact of using a targeted testing approach and 2 interferon-gamma release assays (IGRA) to screen for latent tuberculosis (TB) infection (LTBI) among military recruits. The current policy of universal application of the Mantoux tuberculin skin test (TST) to screen for LTBI may result in many TST reactions among recruits who are at low risk for LTBI. The central hypothesis is that targeted testing by use of the questionnaire will reduce unnecessary testing of low-risk recruits without affecting the identification of higher-risk recruits. The secondary hypothesis is that many discordant results between the TST and IGRA may be explained by cross-reactivity to non-tuberculous mycobacteria (NTM) with the TST.

Detailed description:

Arms:
arm 1: Subjects administered the TB skin test, Battey skin test, QFT-GIT, and T-Spot

Interventions: intervention 1: BST intervention 2: TST intervention 3: QFT intervention 4: T-spot
Intervention descriptions: intervention 1: 0.1 mcg/mL (1 dose) Battey skin test (BST) antigen administered using the Mantoux method. intervention 2: Administer TB Skin test (TST) intervention 3: Perform QFT TB test intervention 4: Perform T-Spot TB test

Protocol document: