Conditions: Dry Eye
Allocation: RANDOMIZED | Intervention model: PARALLEL
Enrollment: 30
Healthy volunteers: yes

Brief summary:
This 6 month study seeks to compare the use of Intracanalicular Dexamethasone in conjunction with Restasis (cyclosporine ophthalmic emulsion) for the treatment of signs and symptoms of dry eye disease as compared to Restasis with Lotemax (loteprednol etabonate ophthalmic suspension 0.5%) and Restasis monotherapy.

Detailed description:

Arms:
arm 1: 10 subjects will be receiving Restasis ophthalmic solution twice a day in both eyes and Lotemax ophthalmic solution twice a day in both eyes. arm 2: 10 subjects will be receiving Restasis ophthalmic solution twice a day in both eyes, as well as receiving Dextenza insertion in both lower lids. arm 3: 10 subjects will be receiving Restasis ophthalmic solution twice a day in both eyes

Interventions: intervention 1: Cyclosporine intervention 2: Loteprednol Etabonate intervention 3: Dexamethasone Ophthalmic 0.4 Mg Ophthalmic Insert
Intervention descriptions: intervention 1: Used to increase tear production in patients who have dry eye caused by inflammation intervention 2: Used to treat inflammation of the eye intervention 3: Used to treat inflammation of the eye

Protocol document:
Prot_000.pdf: 











































SAP_001.pdf: