Query: Hidradenitis Suppurativa in Children Treated with Finasteride-A Case Series.

Relevant passages:
Early-onset hidradenitis suppurativa. <=SEP=> A 9-year-old girl developed hidradenitis suppurativa 3 months after the first signs of adrenarche. Such a close temporal relationship is consistent with the hypothesis that the disease is androgen dependent. Less than 2% of patients have onset of the disease before the age of 11 years. The exceptionally early age of onset in our patient may be partly explained by the fact that she had an early puberty.

Prepubertal hidradenitis suppurativa: two case reports and review of the literature. <=SEP=> Hidradenitis suppurativa (HS) is a chronic suppurative scarring disease of apocrine sweat gland-bearing skin in the axillary, anogenital, and, rarely, the breast and scalp regions. Females are more commonly affected than males and it is usually seen at puberty or later. We report two girls with prepubertal hidradenitis suppurativa whose initial presentation predated any signs of puberty. This early onset is very rare and its etiology remains unknown. Severe disease can be seen in prepubertal children and surgical intervention is effective in these cases.

Finasteride for the treatment of hidradenitis suppurativa in children and adolescents. <=SEP=> IMPORTANCE
Hidradenitis suppurativa (HS) is a chronic debilitating cutaneous disease for which there is no universally effective treatment. Patients typically present at puberty with tender subcutaneous nodules that can progress to dermal abscess formation. Antiandrogens have been used in the treatment of HS, and studies have primarily focused on adult patients.


OBSERVATIONS
We present a case series of 3 pediatric patients with HS who were successfully treated with oral finasteride, resulting in decreased frequency and severity of disease flares with no significant adverse effects.


CONCLUSIONS AND RELEVANCE
Finasteride is a therapeutic option that provides benefit for pediatric patients with HS. Further prospective data and randomized controlled studies will provide helpful information in the management of this disease.

Hidradenitis suppurativa in children and adolescents: a review of treatment options. <=SEP=> Hidradenitis suppurativa (HS) is a burdensome disease and has the potential to affect the life course of patients. It is a rare disease in children, and the recorded literature is correspondingly scarce. This article reviews the therapeutic options for HS in children and adolescents, and highlights particular differences or challenges with treating patients in this age group compared with adults. The work-up of paediatric patients with HS should include considerations of possible endocrine co-morbidities and obesity. Medical therapy of lesions may include topical clindamycin. Systemic therapy may include analgesics, clindamycin and rifampicin, finasteride, corticosteroids or tumour necrosis factor alpha (TNFα) blockers. Superinfections should be appropriately treated. Scarring lesions generally require surgery.

Morbidity in patients with hidradenitis suppurativa. <=SEP=> BACKGROUND
Although skin diseases are often immediately visible to both patients and society, the morbidity they cause is only poorly defined. It has been suggested that quality-of-life measures may be a relevant surrogate measure of skin disease. Hidradenitis suppurativa (HS) leads to painful eruptions and malodorous discharge and is assumed to cause a significant degree of morbidity. The resulting impairment of life quality has not previously been quantitatively assessed, although such an assessment may form a pertinent measure of disease severity in HS.


OBJECTIVES
To measure the impairment of life quality in patients with HS.


METHODS
In total, 160 patients suffering from HS were approached. The following data were gathered: quality-of-life data (Dermatology Life Quality Index, DLQI questionnaire), basic demographic data, age at onset of the condition and the average number of painful lesions per month.


RESULTS
One hundred and fourteen patients participated in the study. The mean +/- SD age of the patients was 40.9 +/- 11.7 years, the mean +/- SD age at onset 21.8 +/- 9.9 years and the mean +/- SD duration of the disease 18.8 +/- 11.4 years. Patients had a mean +/- SD DLQI score of 8.9 +/- 8.3 points. The highest mean score out of the 10 DLQI questions was recorded for question 1, which measures the level of pain, soreness, stinging or itching (mean 1.55 points, median 2 points). Patients experienced a mean of 5.1 lesions per month.


CONCLUSIONS
HS causes a high degree of morbidity, with the highest scores obtained for the level of pain caused by the disease. The mean DLQI score for HS was higher than for previously studied skin diseases, and correlated with disease intensity as expressed by lesions per month. This suggests that the DLQI may be a relevant outcome measure in future therapeutic trials in HS.

Real-Time Mental Arithmetic Task Recognition From EEG Signals <=SEP=> Electroencephalography (EEG)-based monitoring the state of the user's brain functioning and giving her/him the visual/audio/tactile feedback is called neurofeedback technique, and it could allow the user to train the corresponding brain functions. It could provide an alternative way of treatment for some psychological disorders such as attention deficit hyperactivity disorder (ADHD), where concentration function deficit exists, autism spectrum disorder (ASD), or dyscalculia where the difficulty in learning and comprehending the arithmetic exists. In this paper, a novel method for multifractal analysis of EEG signals named generalized Higuchi fractal dimension spectrum (GHFDS) was proposed and applied in mental arithmetic task recognition from EEG signals. Other features such as power spectrum density (PSD), autoregressive model (AR), and statistical features were analyzed as well. The usage of the proposed fractal dimension spectrum of EEG signal in combination with other features improved the mental arithmetic task recognition accuracy in both multi-channel and one-channel subject-dependent algorithms up to 97.87% and 84.15% correspondingly. Based on the channel ranking, four channels were chosen which gave the accuracy up to 97.11%. Reliable real-time neurofeedback system could be implemented based on the algorithms proposed in this paper.

Cognitive control signals for neural prosthetics. <=SEP=> Recent development of neural prosthetics for assisting paralyzed patients has focused on decoding intended hand trajectories from motor cortical neurons and using this signal to control external devices. In this study, higher level signals related to the goals of movements were decoded from three monkeys and used to position cursors on a computer screen without the animals emitting any behavior. Their performance in this task improved over a period of weeks. Expected value signals related to fluid preference, the expected magnitude, or probability of reward were decoded simultaneously with the intended goal. For neural prosthetic applications, the goal signals can be used to operate computers, robots, and vehicles, whereas the expected value signals can be used to continuously monitor a paralyzed patient's preferences and motivation.

Mining User Mobility Features for Next Place Prediction in Location-Based Services <=SEP=> Mobile location-based services are thriving, providing an unprecedented opportunity to collect fine grained spatio-temporal data about the places users visit. This multi-dimensional source of data offers new possibilities to tackle established research problems on human mobility, but it also opens avenues for the development of novel mobile applications and services. In this work we study the problem of predicting the next venue a mobile user will visit, by exploring the predictive power offered by different facets of user behavior. We first analyze about 35 million check-ins made by about 1 million Foursquare users in over 5 million venues across the globe, spanning a period of five months. We then propose a set of features that aim to capture the factors that may drive users' movements. Our features exploit information on transitions between types of places, mobility flows between venues, and spatio-temporal characteristics of user check-in patterns. We further extend our study combining all individual features in two supervised learning models, based on linear regression and M5 model trees, resulting in a higher overall prediction accuracy. We find that the supervised methodology based on the combination of multiple features offers the highest levels of prediction accuracy: M5 model trees are able to rank in the top fifty venues one in two user check-ins, amongst thousands of candidate items in the prediction list.

Two/Too Simple Adaptations of Word2Vec for Syntax Problems <=SEP=> We present two simple modifications to the models in the popular Word2Vec tool, in order to generate embeddings more suited to tasks involving syntax. The main issue with the original models is the fact that they are insensitive to word order. While order independence is useful for inducing semantic representations, this leads to suboptimal results when they are used to solve syntax-based problems. We show improvements in part-ofspeech tagging and dependency parsing using our proposed models.

Digital Fabrication Techniques for Cultural Heritage: A Survey <=SEP=> Digital fabrication devices exploit basic technologies in order to create tangible reproductions of 3D digital models. Although current 3D printing pipelines still suffer from several restrictions, accuracy in reproduction has reached an excellent level. The manufacturing industry has been the main domain of 3D printing applications over the last decade. Digital fabrication techniques have also been demonstrated to be effective in many other contexts, including the consumer domain. The Cultural Heritage is one of the new application contexts and is an ideal domain to test the flexibility and quality of this new technology. This survey overviews the various fabrication technologies, discussing their strengths, limitations, and costs. Various successful uses of 3D printing in the Cultural Heritage are analysed, which should also be useful for other application contexts. We review works that have attempted to extend fabrication technologies in order to deal with the specific issues in the use of digital fabrication in the Cultural Heritage. Finally, we also propose areas for future research.

A Multi-Cloud Framework for Measuring and Describing Performance Aspects of Cloud Services Across Different Application Types <=SEP=> Cloud services have emerged as an innovative IT provisioning model in the recent years. However, after their usage severe considerations have emerged with regard to their varying performance due to multitenancy and resource sharing issues. These issues make it very difficult to provide any kind of performance estimation during application design or deployment time. The aim of this paper is to present a mechanism and process for measuring the performance of various Cloud services and describing this information in machine understandable format. The framework is responsible for organizing the execution and can support multiple Cloud providers. Furthermore we present approaches for measuring service performance with the usage of specialized metrics for ranking the services according to a weighted combination of cost, performance and workload.

Design of novel capacitive type torque sensor for robotic applications <=SEP=> This paper introduces a novel capacitive type torque sensor. The developed torque sensor measures single axis torque value by using two capacitance transducing cells. To make a linear relation between the capacitance and the deformation, the shape of flexure hinge is considered to be deformed constantly. Also, the nonlinear curve fitting method is used to fit the capacitance linearly. Finally, the performance of the sensor is verified in reference to a commercial torque sensor.

Overview of High-Step-Up Coupled-Inductor Boost Converters <=SEP=> High-step-up, high-efficiency, and cost-effective dc-dc converters, serving as an interfacing cell to boost the low-voltage output of renewable sources to the utility voltage level, are an important part in renewable energy systems. Over the past few years, there has been a substantial amount of studies devoted to high-step-up dc-dc converters. Among them, the category of coupled-inductor boost converters is widely researched and considered to be a promising solution for high-step-up applications. In this paper, these converters are categorized into five groups according to the major topological features. The derivation process, advantages, and disadvantages of these converters are systematically discussed, compared, and scrutinized. This paper aims to provide an introduction, review, and framework for the category of high-step-up coupled-inductor boost converters. General structures for the topologies are proposed to clarify the topological derivation process and to show potential gaps. Furthermore, challenges or directions are presented in this paper for deriving new topologies in this field.

Design and Analysis of a Two Stage Operational Amplifier for High Gain and High Bandwidth <=SEP=> In this paper a design and comparison between a fully differential RC Miller compensated CMOS op-amp and conventional op-amp is presented. High gain enables the circuit to operate efficiently in a closed loop feedback system, whereas high bandwidth makes it suitable for high speed applications. A novel RC Miller compensation technique is used to optimize the parameters of gain and bandwidth for high speed applications are illustrated in this research work. The design is also able to address any fluctuation in supply or dc input voltages and stabilizes the operation by nullifying. The design is implemented on TSMC 0.18 m CMOS process at 3.3 V as supply voltage under room temperature 27 C. The simulated result shows that a unity gain bandwidth of 136.8 MHz with a high gain of 92.27 dB is achieved for the proposed op-amp circuit. The total areas of the layouts are 0.000158 mm and 0.000532 mm for conventional and proposed respectively. Key wrods: Two-Stage Op-amp, fully differential, high gain, high bandwidth

Assembler: Efficient Discovery of Spatial Co-evolving Patterns in Massive Geo-sensory Data <=SEP=> Recent years have witnessed the wide proliferation of geo-sensory applications wherein a bundle of sensors are deployed at different locations to cooperatively monitor the target condition. Given massive geo-sensory data, we study the problem of mining spatial co-evolving patterns (SCPs), i.e., groups of sensors that are spatially correlated and co-evolve frequently in their readings. SCP mining is of great importance to various real-world applications, yet it is challenging because (1) the truly interesting evolutions are often flooded by numerous trivial fluctuations in the geo-sensory time series; and (2) the pattern search space is extremely large due to the spatiotemporal combinatorial nature of SCP. In this paper, we propose a two-stage method called Assember. In the first stage, Assember filters trivial fluctuations using wavelet transform and detects frequent evolutions for individual sensors via a segment-and-group approach. In the second stage, Assember generates SCPs by assembling the frequent evolutions of individual sensors. Leveraging the spatial constraint, it conceptually organizes all the SCPs into a novel structure called the SCP search tree, which facilitates the effective pruning of the search space to generate SCPs efficiently. Our experiments on both real and synthetic data sets show that Assember is effective, efficient, and scalable.

A Markov Model for Headway/Spacing Distribution of Road Traffic <=SEP=> In this paper, we link two research directions of road traffic-the mesoscopic headway distribution model and the microscopic vehicle interaction model-together to account for the empirical headway/spacing distributions. A unified car-following model is proposed to simulate different driving scenarios, including traffic on highways and at intersections. Unlike our previous approaches, the parameters of this model are directly estimated from the Next Generation Simulation (NGSIM) Trajectory Data. In this model, empirical headway/spacing distributions are viewed as the outcomes of stochastic car-following behaviors and the reflections of the unconscious and inaccurate perceptions of space and/or time intervals that people may have. This explanation can be viewed as a natural extension of the well-known psychological car-following model (the action point model). Furthermore, the fast simulation speed of this model will benefit transportation planning and surrogate testing of traffic signals.

Design of a Marx Generator for HEMP filter evaluation taking account of parasitic effect of components <=SEP=> This paper introduces the design of a Marx Generator that can generate high attitude pulses up to 25 kV and 2.5 kA. The pulses have a wave shape representative of that used to test High-altitude ElectroMagnetic (HEMP) filters against the pulse current injection (PCI) requirements. The rise time is 20 ns and the pulse width is 230 ns on a 10 Ω resistor. In the design, it was found that parasitic effect of circuit components could significantly affect the performance of the generator. This is mainly because the pulse width is very narrow and its frequency spectrum is very wideband. The high-frequency circuit models of the components used in the generator were obtained by calculation and optimization, and then further verified by experiment. The verified circuit models were then used to design the three-stage generator. The measured performance agrees very well with the simulated one using the proposed circuit models.

Simultaneous algebraic reconstruction technique (SART): a superior implementation of the art algorithm. <=SEP=> In this paper we have discussed what appears to be a superior implementation of the Algebraic Reconstruction Technique (ART). The method is based on 1) simultaneous application of the error correction terms as computed by ART for all rays in a given projection; 2) longitudinal weighting of the correction terms back-distributed along the rays; and 3) using bilinear elements for discrete approximation to the ray integrals of a continuous image. Since this implementation generates a good reconstruction in only one iteration, it also appears to have a computational advantage over the more traditional implementation of ART. Potential applications of this implementation include image reconstruction in conjunction with ray tracing for ultrasound and microwave tomography in which the curved nature of the rays leads to a non-uniform ray density across the image.

Brain activation during human male ejaculation. <=SEP=> Brain mechanisms that control human sexual behavior in general, and ejaculation in particular, are poorly understood. We used positron emission tomography to measure increases in regional cerebral blood flow (rCBF) during ejaculation compared with sexual stimulation in heterosexual male volunteers. Manual penile stimulation was performed by the volunteer's female partner. Primary activation was found in the mesodiencephalic transition zone, including the ventral tegmental area, which is involved in a wide variety of rewarding behaviors. Parallels are drawn between ejaculation and heroin rush. Other activated mesodiencephalic structures are the midbrain lateral central tegmental field, zona incerta, subparafascicular nucleus, and the ventroposterior, midline, and intralaminar thalamic nuclei. Increased activation was also present in the lateral putamen and adjoining parts of the claustrum. Neocortical activity was only found in Brodmann areas 7/40, 18, 21, 23, and 47, exclusively on the right side. On the basis of studies in rodents, the medial preoptic area, bed nucleus of the stria terminalis, and amygdala are thought to be involved in ejaculation, but increased rCBF was not found in any of these regions. Conversely, in the amygdala and adjacent entorhinal cortex, a decrease in activation was observed. Remarkably strong rCBF increases were observed in the cerebellum. These findings corroborate the recent notion that the cerebellum plays an important role in emotional processing. The present study for the first time provides insight into which regions in the human brain play a primary role in ejaculation, and the results might have important implications for our understanding of how human ejaculation is brought about, and for our ability to improve sexual function and satisfaction in men.

Data Center Energy Consumption Modeling: A Survey <=SEP=> Data centers are critical, energy-hungry infrastructures that run large-scale Internet-based services. Energy consumption models are pivotal in designing and optimizing energy-efficient operations to curb excessive energy consumption in data centers. In this paper, we survey the state-of-the-art techniques used for energy consumption modeling and prediction for data centers and their components. We conduct an in-depth study of the existing literature on data center power modeling, covering more than 200 models. We organize these models in a hierarchical structure with two main branches focusing on hardware-centric and software-centric power models. Under hardware-centric approaches we start from the digital circuit level and move on to describe higher-level energy consumption models at the hardware component level, server level, data center level, and finally systems of systems level. Under the software-centric approaches we investigate power models developed for operating systems, virtual machines and software applications. This systematic approach allows us to identify multiple issues prevalent in power modeling of different levels of data center systems, including: i) few modeling efforts targeted at power consumption of the entire data center ii) many state-of-the-art power models are based on a few CPU or server metrics, and iii) the effectiveness and accuracy of these power models remain open questions. Based on these observations, we conclude the survey by describing key challenges for future research on constructing effective and accurate data center power models.

Differential quasi self-complimentary (QSC) ultra-wideband (UWB) MIMO antenna <=SEP=> In this paper, a differentially excited ultra-wideband (UWB) MIMO antenna is designed for pattern diversity applications, utilizing quasi self-complimentary (QSC) antenna elements. Four QSC elements are realized using half- octagon shaped monopoles, and their complementary cuts from the ground plane. Due to the QSC property, wide impedance bandwidth covering the UWB frequency range of 3–11 GHz is achieved within very less antenna footprint. The QSC elements are placed symmetrically about the four edges of a square substrate. Two oppositely positioned elements are fed with 180o phase difference, in order to form a single differential pair. Two such differential pairs are placed perpendicular to each other for realizing pattern diversity performance with high value of differential isolation.

Airway management and smoke inhalation injury in the burn patient. <=SEP=> Smoke inhalation injury, a unique form of acute lung injury, greatly increases the occurrence of postburn morbidity and mortality. In addition to early intubation for upper-airway protection, subsequent critical care of patients who have this injury should be directed at maintaining distal airway patency. High-frequency ventilation, inhaled heparin, and aggressive pulmonary toilet are among the therapies available. Even so, immunosuppression, intubation, and airway damage predispose these patients to pneumonia and other complications.

Tibiofemoral movement 1: the shapes and relative movements of the femur and tibia in the unloaded cadaver knee. <=SEP=> In six unloaded cadaver knees we used MRI to determine the shapes of the articular surfaces and their relative movements. These were confirmed by dissection. Medially, the femoral condyle in sagittal section is composed of the arcs of two circles and that of the tibia of two angled flats. The anterior facets articulate in extension. At about 20 degrees the femur 'rocks' to articulate through the posterior facets. The medial femoral condyle does not move anteroposteriorly with flexion to 110 degrees. Laterally, the femoral condyle is composed entirely, or almost entirely, of a single circular facet similar in radius and arc to the posterior medial facet. The tibia is roughly flat. The femur tends to roll backwards with flexion. The combination during flexion of no anteroposterior movement medially (i.e., sliding) and backward rolling (combined with sliding) laterally equates to internal rotation of the tibia around a medial axis with flexion. About 5 degrees of this rotation may be obligatory from 0 degrees to 10 degrees flexion; thereafter little rotation occurs to at least 45 degrees. Total rotation at 110 degrees is about 20 degrees, most if not all of which can be suppressed by applying external rotation to the tibia at 90 degrees.

A Layered Security Approach for Cloud Computing Infrastructure <=SEP=> This paper introduces a practical security model based on key security considerations by looking at a number of infrastructure aspects of Cloud Computing such as SaaS, Utility, Web, Platform and Managed Services, Service commerce platforms and Internet Integration which was introduced with a concise literature review. The purpose of this paper is to offer a macro level solution for identified common infrastructure security requirements. This model with a number of emerged patterns can be applied to infrastructure aspect of Cloud Computing as a proposed shared security approach in system development life cycle focusing on the plan-built-run scope.

Enhanced Computer Vision With Microsoft Kinect Sensor: A Review <=SEP=> With the invention of the low-cost Microsoft Kinect sensor, high-resolution depth and visual (RGB) sensing has become available for widespread use. The complementary nature of the depth and visual information provided by the Kinect sensor opens up new opportunities to solve fundamental problems in computer vision. This paper presents a comprehensive review of recent Kinect-based computer vision algorithms and applications. The reviewed approaches are classified according to the type of vision problems that can be addressed or enhanced by means of the Kinect sensor. The covered topics include preprocessing, object tracking and recognition, human activity analysis, hand gesture analysis, and indoor 3-D mapping. For each category of methods, we outline their main algorithmic contributions and summarize their advantages/differences compared to their RGB counterparts. Finally, we give an overview of the challenges in this field and future research trends. This paper is expected to serve as a tutorial and source of references for Kinect-based computer vision researchers.

Development of a three-dimensional ball rotation sensing system using optical mouse sensors <=SEP=> Robots using ball(s) as spherical wheels have the advantage of omnidirectional motion. Some of these robots use only a single ball as their wheel and dynamically balance on it. However, driving a ball wheel is not straightforward. These robots usually use one or more motor-driven rollers or wheels in frictional contact with the ball wheel. Some slippage can occur with these schemes, so it is important to measure the actual rotation of the ball wheel for good control. This paper proposes one method for measuring the three dimensional rotation of a sphere, which is applicable to the case of a ball wheel. The system measures surface speed by using two or more optical mouse sensors and transforms them into the angular velocity vector of the ball, followed by integration to give the rotational angle. Experiments showed the correctness of this method, yielding an error of approximately 1%, with a 10 ms response.

IMPLEMNTATION OF SIMULINK BASED MODEL USING SOBEL EDGE DETECTOR FOR DENTAL PROBLEMS Deepika Nagpal <=SEP=> Image Segmentation is the process of partitioning a digital image into multiple regions or sets of pixels.Edge Detection is one of the main Technique used in Segmentation.In this paper we used Sobel edge detector for segmenting the dental X-ray image.Using MATLAB,Image is segmented.Sysytem Test tool is used for the verification of the Simulink Model. The Simulink Model based Image Segmentation is a new function in image processing and offers a model based design for processing. Dental Caries is the main problem occurred in the teeths.Segmentation help to identify the places where the problems of dental caries are present.

Predicting conversion from MCI to AD with FDG-PET brain images at different prodromal stages <=SEP=> Early diagnosis of Alzheimer disease (AD), while still at the stage known as mild cognitive impairment (MCI), is important for the development of new treatments. However, brain degeneration in MCI evolves with time and differs from patient to patient, making early diagnosis a very challenging task. Despite these difficulties, many machine learning techniques have already been used for the diagnosis of MCI and for predicting MCI to AD conversion, but the MCI group used in previous works is usually very heterogeneous containing subjects at different stages. The goal of this paper is to investigate how the disease stage impacts on the ability of machine learning methodologies to predict conversion. After identifying the converters and estimating the time of conversion (TC) (using neuropsychological test scores), we devised 5 subgroups of MCI converters (MCI-C) based on their temporal distance to the conversion instant (0, 6, 12, 18 and 24 months before conversion). Next, we used the FDG-PET images of these subgroups and trained classifiers to distinguish between the MCI-C at different stages and stable non-converters (MCI-NC). Our results show that MCI to AD conversion can be predicted as early as 24 months prior to conversion and that the discriminative power of the machine learning methods decreases with the increasing temporal distance to the TC, as expected. These findings were consistent for all the tested classifiers. Our results also show that this decrease arises from a reduction in the information contained in the regions used for classification and by a decrease in the stability of the automatic selection procedure.

Graph Partitioning using Quantum Annealing on the D-Wave System <=SEP=> Graph partitioning (GP) applications are ubiquitous throughout mathematics, computer science, chemistry, physics, bio-science, machine learning, and complex systems. Post Moore's era supercomputing has provided us an opportunity to explore new approaches for traditional graph algorithms on quantum computing architectures. In this work, we explore graph partitioning using quantum annealing on the D-Wave 2X machine. Motivated by a recently proposed graph-based electronic structure theory applied to quantum molecular dynamics (QMD) simulations, graph partitioning is used for reducing the calculation of the density matrix into smaller subsystems rendering the calculation more computationally efficient. Unconstrained graph partitioning as community clustering based on the modularity metric can be naturally mapped into the Hamiltonian of the quantum annealer. On the other hand, when constraints are imposed for partitioning into equal parts and minimizing the number of cut edges between parts, a quadratic unconstrained binary optimization (QUBO) reformulation is required. This reformulation may employ the graph complement to fit the problem in the Chimera graph of the quantum annealer. Partitioning into 2 parts and k parts concurrently for arbitrary k are demonstrated with benchmark graphs, random graphs, and small material system density matrix based graphs. Results for graph partitioning using quantum and hybrid classical-quantum approaches are shown to be comparable to current "state of the art" methods and sometimes better.

Typology of Distributed Ledger based Business Models <=SEP=> The potential of distributed ledger technology and its application in various industries is a controversially debated topic. Advocates of the technology emphasize the economic benefits of decentralization and transparency, leading to cost reductions as well as the alleviation of several of today`s economic and technological problems. In contrast, critics assert that the potential of distributed ledgers might be overhyped, possibly leading to the next tech bubble. This paper contributes to the discussion by developing a typology of business models that are based on distributed ledger technology. In particular, this paper is a first step towards a more differentiated discussion on the potential of distributed ledges, by taking the underlying business models into consideration. Despite a characterization of the types, a discussion about special features of distributed ledger based business models is provided in the context of contemporary business model literature and the associated role of IT. It is proposed that future research must evaluate each business model isolated to achieve a comprehensive assessment of the potential of distributed ledgers. This paper can be interpreted as starting point for more fruitful discussions and the repeal of the partially diametrical opposed opinions towards the potentials of the technology.