snu-aidas/HVMap-dataset huggingface dataset:
Impact of carboplatin plus paclitaxel combined with endostar against A375 melanoma cells: An in vitro and in vivo analysis.

PURPOSE
The aim of the present study was to investigate the efficacy of carboplatin plus paclitaxel (CP) combined with endostar against A375 melanoma cells in vitro and in vivo.


METHODS
Effects on the cell viability and apoptosis induction were estimated with the Cell counting Kit-8 assay and Annexin V-FITC/Propidium Iodide staining. Fifty female BALB/c-nude mice with subcutaneous injection of A375 cells were randomized to be treated with normal saline, dacarbazine alone, dacarbazine plus endostar, carboplatin plus paclitaxel, and CP plus endostar. Tumor volume of mice was monitored after injection and survival time was adopted for survival analysis.


RESULTS
CP plus endostar significantly decreased the cell survival rate compared with CP (P<0.01). Combination of CP and endostar showed higher cytotoxicity to A375 cells in vitro than endostar plus dacarbazine (P<0.01). The percentage of apoptotic cells in A375 cells treated with CP plus endostar was appreciably higher when compared to CP group (P<0.05). The mean relative tumor size in CP group was definitely larger (p<0.05) than CP plus endostar group. In addition, the mean survival time in CP plus endostar group was notably elevated compared with the CP group (P<0.05).


CONCLUSIONS
Our data indicated that treatment with CP plus endostar significantly reduced cell growth and induced a high rate of apoptotic cells in the A375 melanoma cell line. CP and endostar exhibited synergistic anti-tumor activities in A375 melanoma cells in vitro. CP plus endostar suppressed the growth of xenograft tumors and prolonged the survival time of mice with xenograft tumors. Combination of CP and endostar may be a promising treatment for melanoma.
Heritability for Alzheimer's disease: the study of dementia in Swedish twins.

BACKGROUND
Alzheimer's disease has been thought to have familial and sporadic forms, and several genetic defects have been identified that chiefly explain early-onset familial cases. In this study, our purpose was to detect all cases of dementia in an established twin registry and to estimate total extent of genetic contribution to liability to Alzheimer's disease.


METHODS
At the first stage, members of the registry were screened for dementia, using in-person or telephone mental status testing. At the second stage, those who screened positively and their partners were referred for clinical work-ups, including neuropsychological assessment, physician examination, laboratory tests, and neuroimaging. Clinical diagnoses were assigned at a multidisciplinary consensus conference. Probandwise concordance rates were examined by zygosity, and structural modeling was applied to the data to estimate genetic and environmental influences, using both single- and multiple-threshold models.


RESULTS
Sixty-five pairs were identified in which one or both was demented. The probandwise concordance rate for Alzheimer's disease among monozygotic pairs was 67%; the corresponding figure for dizygotic pairs was 22%. Heritability of liability to Alzheimer's disease was estimated to be .74; to any dementia, .43. The other variance is attributable to environmental influences.


CONCLUSIONS
Findings indicate a substantial genetic effect for these predominantly late-onset Alzheimer's disease cases. At the same time, structural modeling results and large intra-pair differences in age of onset suggest that environmental factors are also important in determining whether and when an individual may develop dementia.
Developing a Feasible and Maintainable Ontology for Automatic Landscape Design

In general, landscape architecture includes analysis, planning, design, administration and management of natural and artificial. An important aspect is the formation of socalled sustainable landscapes that allow maximum use of the environment, natural resources and promote sustainable restoration of ecosystems. For such purposes, a designer needs a complete database with existing and suitable plants, but no designing tool has one. Therefore it is presented the structure and the development of on ontology suitable for storing and managing all information and knowledge about plants. The advantage is that the format of the ontology allows the storage of any plant species (e.g. live or fossil) and automated reasoning. Ontology is a formal conceptualization of a particular knowledge about the world, through the explicit representation of basic concepts, relations, and inference rules about themselves. Therefore the ontology may be used by a design tool for helping the designer and choosing the best options for a sustainable landscape. Keywords—environment; landscapes; ontology; ontology-based simulation; sustainable landscapes
Soft Robot Arm Inspired by the Octopus

The octopus is a marine animal whose body has no rigid structures. It has eight arms composed of a peculiar muscular structure, named a muscular hydrostat. The octopus arms provide it with both locomotion and grasping capabilities, thanks to the fact that their stiffness can change over a wide range and can be controlled through combined contractions of the muscles. The muscular hydrostat can better be seen as a modifiable skeleton. Furthermore, the morphology the arms and the mechanical characteristics of their tissues are such that the interaction with the environment (i.e., water) is exploited to simplify control. Thanks to this effective mechanism of embodied intelligence, the octopus can control a very high number of degrees of freedom, with relatively limited computing resources. From these considerations, the octopus emerges as a good model for embodied intelligence and for soft robotics. The prototype of a robot arm has been built based on an artificial muscular hydrostat inspired to the muscular hydrostat of the Octopus vulgaris. The prototype presents the morphology of the biological model and the broad arrangement of longitudinal and transverse muscles. Actuation is obtained with cables (longitudinally) and with shape memory alloy springs (transversally). The robot arm combines contractions and it can show the basic movements of the octopus arm, like elongation, shortening and bending, in water. © Koninklijke Brill NV, Leiden and The Robotics Society of Japan, 2012
Visceral pain: the ins and outs, the ups and downs.

PURPOSE OF REVIEW
Visceral pain represents a major clinical problem, yet far less is known about its mechanisms compared with somatic pains, for example, from cutaneous and muscular structures.


RECENT FINDINGS
In this review, we describe the neuroanatomical bases of visceral pain signalling in the peripheral and central nervous system, comparing to somatic pains and also the channels and receptors involved in these events. We include an overview of potential new targets in the context of mechanisms of visceral pain and hypersensitivity.


SUMMARY
This review should inform on the recognition of what occurs in patients with visceral pain, why comorbidities are common and how analgesic treatments work.
An Anatomical Analysis of the Supratrochlear Artery: Considerations in Facial Filler Injections and Preventing Vision Loss.

BACKGROUND
Embolia cutis medicamentosa (ECM) is a rare phenomenon attributed to intra-arterial drug injection. Glabellar filler injections can result in potentially devastating visual loss from inadvertent retrograde arteriolar embolization due to the extensive vasculature within the upper face. The minimum amount of filler necessary to potentiate this complication has not yet been reported.


OBJECTIVES
We aim to determine the volume of filler necessary to occupy the supratrochlear artery from the glabella to the bifurcation of the ophthalmic and central retinal arteries. We specifically examine the volume of the supratrochlear artery from the glabella to orbital apex.


METHODS
The study was approved by Duke University Institutional Review Board and involved surgical dissection of six fresh tissue cadaver heads (12 hemifaces). The arterial system in each cadaver head was injected with latex for visualization. The supratrochlear arteries were isolated anteriorly from the glabella to the orbital apex posteriorly. Intra-orbital vessel radius and length were measured. The vessel volume was calculated by water displacement of the intra-arterial latex.


RESULTS
The vessel volumes ranged from 0.04 to 0.12 mL. The average vessel volume was calculated as 0.085 mL, the average length as 51.75 mm, and the average radius as 0.72 mm.


CONCLUSIONS
Vascular occlusion from filler injections can lead to devastating visual consequences due to inadvertent retrograde intra-arterial embolization. Our findings indicate that the average entire volume of the supratrochlear artery from the glabella to the orbital apex is 0.085 mL. Injectors should be aware that a bolus of this critical volume may lead to a significant adverse outcome.
Solving POMDPs with Levin Search and EIRA

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A Syntactic Resource for Thai: CG Treebank

This paper presents Thai syntactic resource: Thai CG treebank, a categorial approach of language resources. Since there are very few Thai syntactic resources, we designed to create treebank based on CG formalism. Thai corpus was parsed with existing CG syntactic dictionary and LALR parser. The correct parsed trees were collected as preliminary CG treebank. It consists of 50,346 trees from 27,239 utterances. Trees can be split into three grammatical types. There are 12,876 sentential trees, 13,728 noun phrasal trees, and 18,342 verb phrasal trees. There are 17,847 utterances that obtain one tree, and an average tree per an utterance is 1.85.
BatchQC: interactive software for evaluating sample and batch effects in genomic data

Sequencing and microarray samples often are collected or processed in multiple batches or at different times. This often produces technical biases that can lead to incorrect results in the downstream analysis. There are several existing batch adjustment tools for '-omics' data, but they do not indicate a priori whether adjustment needs to be conducted or how correction should be applied. We present a software pipeline, BatchQC, which addresses these issues using interactive visualizations and statistics that evaluate the impact of batch effects in a genomic dataset. BatchQC can also apply existing adjustment tools and allow users to evaluate their benefits interactively. We used the BatchQC pipeline on both simulated and real data to demonstrate the effectiveness of this software toolkit.


AVAILABILITY AND IMPLEMENTATION
BatchQC is available through Bioconductor: http://bioconductor.org/packages/BatchQC and GitHub: https://github.com/mani2012/BatchQC CONTACT: wej@bu.eduSupplementary information: Supplementary data are available at Bioinformatics online.
Male-to-female transsexualism: technique, results and 3-year follow-up in 50 patients.

AIM
To evaluate the functional and cosmetic results of male-to-female gender-transforming surgery.


PATIENTS AND METHODS
Between May 2001 and April 2008 we performed 50 male-to-female gender-transforming surgeries. All patients had been cross-dressing, living as women, and receiving estrogen and progesterone for at least 12 months, which was sufficient for breast development and atrophy of the testes and prostate to occur. This hormonal therapy was suspended 1 month before the operation.


RESULTS
The mean operative time was 190 min and the mean depth of the vagina was 10 cm. On follow-up, the most common complication (10%) was shrinkage of the neovagina, which could be corrected by a second surgical intervention. Of the 50 patients, 45 (90%) were satisfied with the esthetic results; 42 patients (84%) reported having regular sexual intercourse, 2 of whom had pain during intercourse. Of the 50 patients, 35 (70%) reported achieving clitoral orgasm.


CONCLUSION
Male-to-female gender-transforming surgery can assure satisfactory cosmetic and functional results, with a reduced intra- and postoperative morbidity. Nevertheless the experience of the surgeon and the center remains central to obtaining optimal results.
Hard Words

How do children acquire the meaning of words? And why are words such as know harder for learners to acquire than words such as dog or jump? We suggest that the chief limiting factor in acquiring the vocabulary of natural languages consists not in overcoming conceptual difficulties with abstract word meanings but rather in mapping these meanings onto their corresponding lexical forms. This opening premise of our position, while controversial, is shared with some prior approaches. The present discussion moves forward from there to a detailed proposal for how the mapping problem for the lexicon is solved, as well as a presentation of experimental findings that support thisaccount.Wedescribeanoverlappingseriesofsteps throughwhichnovicesmove in representing the lexical forms and phrase structures of the exposure language, a probabilistic multiple-cue learning process known as syntactic bootstrapping. The machinery is set inmotionbyword-to-worldpairing, aprocedureavailable tonovices fromthe LANGUAGE LEARNING AND DEVELOPMENT, 1(1), 23–64 Copyright © 2005, Lawrence Erlbaum Associates, Inc.
Mid-face Rejuvenation Mr Dalvi Humzah and

With age, the mid-face changes due to a combination of remodelling of the maxilla and pyriform aperture, volumetric and positional changes of the superficial and deep mid-facial fat pads, and changes in skin tone and texture. It is widely accepted that these changes significantly influence many of the visual changes in the lower face. These may be effectively treated with a variety of injectable techniques to rejuvenate the mid-face. The current literature concerning the pertinent anatomy for mid-facial rejuvenation is therefore discussed within this article. Introduction In recent years, the way we analyse and plan the non-surgical approach to the mid-face has changed dramatically. The focus has shifted away from treating visible lines/folds as they present, and is now centred on treating the age-related changes at the root cause. The restoration of a dynamic and harmonious volume distribution is a key factor in non-surgical rejuvenation of the mid-face. There is a growing body of literature demonstrating the multifactorial nature of facial ageing. These indicate that facial analysis and subsequent rejuvenation should initially address such anatomical changes. An understanding of the anatomical changes associated with ageing is required to formulate effective strategies to rejuvenate the ageing mid-face.
Synthesizing data for text recognition with style transfer

Most of the existing datasets for scene text recognition merely consist of a few thousand training samples with a very limited vocabulary, which cannot meet the requirement of the state-of-the-art deep learning based text recognition methods. Meanwhile, although the synthetic datasets (e.g., SynthText90k) usually contain millions of samples, they cannot fit the data distribution of the small target datasets in natural scenes completely. To address these problems, we propose a word data generating method called SynthText-Transfer, which is capable of emulating the distribution of the target dataset. SynthText-Transfer uses a style transfer method to generate samples with arbitray text content, which preserve the texture of the reference sample in the target dataset. The generated images are not only visibly similar with real images, but also capable of improving the accuracy of the state-of-the-art text recognition methods, especially for the English and Chinese dataset with a large alphabet (in which many characters only appear in few samples, making it hard to learn for sequence models). Moreover, the proposed method is fast and flexible, with a competitive speed among common style transfer methods.
Measuring student engagement in upper elementary through high school : a description of 21 instruments January 2011
Enterprise architecture modelling--the issue of integration

The problem of aligning and integrating business and IT is hampering many companies in their strategic and tactical development. Constructing integrated architecture models contributes to tackling this problem. Unfortunately, no enterprise architecture description language currently exists that fully enables integrated enterprise modelling. A variety of architectural domains are commonly distinguished for which architects use their own modelling techniques and concepts, tool support, visualisation techniques, etc. In this paper we outline such an integrated language and describe concepts that relate architectural domains. This language also serves as a bridge between other existing modelling languages. Furthermore, we present the design of a workbench for enterprise architecture that serves as a modelling tool and a tool integration environment at the same time: it supports both the integration of models in existing modelling languages and the integration of existing modelling tools. q 2005 Elsevier Ltd. All rights reserved.
Fiber-Reinforced Polymer Composites for Construction — State-ofthe-Art Review

A concise state-of-the-art survey of fiber-reinforced polymer ~also known as fiber-reinforced plastic ! composites for construc tion applications in civil engineering is presented. The paper is organized into separate sections on structural shapes, bridge dec reinforcements, externally bonded reinforcements, and standards and codes. Each section includes a historical review, the curr the art, and future challenges. DOI: 10.1061/ ~ASCE!1090-0268~2002!6:2~73! CE Database keywords: Composite materials; Fiber-reinforced materials; Polymers; Bridge decks; State-of-the-art reviews. rials sive uilt , th To So-
Physical and mental health effects of intimate partner violence for men and women.

BACKGROUND
Few population-based studies have assessed the physical and mental health consequences of both psychological and physical intimate partner violence (IPV) among women or men victims. This study estimated IPV prevalence by type (physical, sexual, and psychological) and associated physical and mental health consequences among women and men.


METHODS
The study analyzed data from the National Violence Against Women Survey (NVAWS) of women and men aged 18 to 65. This random-digit-dial telephone survey included questions about violent victimization and health status indicators.


RESULTS
A total of 28.9% of 6790 women and 22.9% of 7122 men had experienced physical, sexual, or psychological IPV during their lifetime. Women were significantly more likely than men to experience physical or sexual IPV (relative risk [RR]=2.2, 95% confidence interval [CI]=2.1, 2.4) and abuse of power and control (RR=1.1, 95% CI=1.0, 1.2), but less likely than men to report verbal abuse alone (RR=0.8, 95% CI=0.7, 0.9). For both men and women, physical IPV victimization was associated with increased risk of current poor health; depressive symptoms; substance use; and developing a chronic disease, chronic mental illness, and injury. In general, abuse of power and control was more strongly associated with these health outcomes than was verbal abuse. When physical and psychological IPV scores were both included in logistic regression models, higher psychological IPV scores were more strongly associated with these health outcomes than were physical IPV scores.


CONCLUSIONS
Both physical and psychological IPV are associated with significant physical and mental health consequences for both male and female victims.
Matching and Retrieval of Distorted and Occluded Shapes Using Dynamic Programming

We propose an approach for matching distorted and possibly occluded shapes using Dynamic Programming (DP). We distinguish among various cases of matching such as cases where the shapes are scaled with respect to each other and cases where an open shape matches the whole or only a part of another open or closed shape. Our algorithm treats noise and shape distortions by allowing matching of merged sequences of consecutive small segments in a shape with larger segments of another shape, while being invariant to translation, scale, orientation and starting point selection. We illustrate the effectiveness of our algorithm in retrieval of shapes on two datasets of two-dimensional open and closed shapes of marine life species. We demonstrate the superiority of our approach over traditional approaches to shape matching and retrieval based on Fourier descriptors and moments. We also compare our method with SQUID, a well known method which is available on the Internet. Our evaluation is based on human relevance judgments following a well-established methodology from the information retrieval field. A preliminary version of this work was presented at the Int. Conf. on Pattern Recognition, Barcelona, Spain, pages 67-71, Vol. 4, Sept. 2000. Corresponding author. Department of Electronic and Computer Engineering, Technical University of Crete, Chania, Crete, GR-73100, Greece, E-mail: petrakis@ced.tuc.gr, URL: http://www.ced.tuc.gr/ ̃petrakis, Intelligent Sensory Information Systems, Faculty of Science, University of Amsterdam, Kruislaan 403, 1098 SJ Amsterdam, The Netherlands. E-mail: diplaros@science.uva.nl. This work is part of the author’s student dissertation at the Department of Electronic and Computer Engineering of the Technical University of Crete. Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1W5. E-mail: eem@cs.dal.ca, URL: http://www.cs.dal.ca/ ̃eem.