skysight-inc/HackerNews huggingface dataset:
> it's not THAT hard. I'm doing something relatively difficult literally in my garage right now

That's great for your cell-based experiments; and many of the greatest biology discoveries were made with this toolset in the first half of the 20th century.

But what about in vivo experiments with mice and rats? What about X-ray crystallography? What about high throughput screening and counterscreening in the range of millions done before a compound is even considered to be a drug candidate?

This is hard stuff, and it's necessary stuff. Exacting conditions are absolutely essential to achieve the highest chance of reproducibility. Even so, it has been famously reported that somewhere around 11% of published findings can be reproduced independently[0].

[0] http://www.nature.com/nature/journal/v483/n7391/full/483531a...
Ideally something c/c++ and liberal license. I'll take a look at ceres-solver to see how it works. Like that it is using Eigen under the hood to get benefit of SSE instructions.
It exists to create jobs in devops.
Interesting news. Good to see developing countries also creating opportunities for developed countries. Thanks to the digital world.
Simply put, Docker is operating system virtualization:

https://en.wikipedia.org/wiki/Operating-system-level_virtual...

Edit: formatting.
This breaks down in hermaphrodite creatures and creatures who change sex.
Lucerne is a city in Switzerland. It exists for about 1200 years longer than Lucene.

https://en.wikipedia.org/wiki/Lucerne
GraphQL in the age of REST APIs
Can we assume the team is intelligent and has general experience with security? Can we assume that the autonomous driving Google team is aware of car-jacking? Can we assume they are able to find a better solution than human driven vehicles?

I say it's up to your friend to construct an argument against the SDC engineering teams being aware of the problem or unable to solve it better than the solution we already have. I have a hard time constructing either.

Extraordinary claims require extraordinary proof.
Facebook Announces Fifth Data Center, Located in Fort Worth, Texas
Why are these labels important to those who use them -- why bother with a "gender" noun and instead use a description of what your sexuality functions as?
Getting a glimpse inside Shopify's Elgin Street headquarters
23andme does, but it doesn't include it in the default report.

You can go to https://www.23andme.com/you/explorer/gene/?gene_name=BHLHE41 and check your raw data to see if you're heterozygotic.
Former Head of HP Enterprise Bill Veghte Is New SurveyMonkey CEO
A five armed mouse study for an anticancer drug runs in the 10-60k range (I can't give my exact quote at the moment). This is inexpensive.

The expensive stuff is when you go into humans.
Am I the only one surprised by Zipapp (since 2.6?). Wish I had known about this before ...
https://docs.python.org/3.5/whatsnew/3.5.html#whatsnew-zipap...
The medium page is not viewable for me apparently due to a copyright issue. Here is an alternative site for the full transcript:

http://www.zerohedge.com/news/2015-07-06/piketty-germany-has...
I'm much less stressed about this after I realized it doesn't take more than 10-15 years of saving to become financially independent. It's seriously stressful to know you have to find a career that can sustain you until 65. Many people seem to have problems fairly early in their tech careers, with rampant ageism etc. So I plan on being FI by 45, preferably 40. So liberating to know my current job could be my last.
yes, assumes annual rebalancing, but static allocation eg. 60/40 stocks/bonds.

you're retiring for 30 years so you generally do better with a hefty allocation of stocks. try it, that's what the calculator is for :)

given an average return over your retirement, the order and volatility of returns has a significant impact on the amount it's safe to spend.

by choosing a less volatile portfolio you reduce risk allowing you to safely spend more, but you also reduce the return forcing you to spend less.

that's why I did the calculator, how to allocate and how much is safe to spend is not a question with an obvious answer.

there's a tradeoff between desire to spend as much as possible, on the one hand, and shortfall risk, on the other. interestingly, approaches that reduce equity allocation as you get older don't really improve the tradeoff much v. a static equity allocation.
Do you have plans for giving it the capability of analyzing images as well as text?
This article[0] describes how it went down: oddly-priced currency swaps. Note that the article is from 2003, and makes clear that other member states such as Italy, at the very least, were using similar practices as far back as 1996.

Most people are shocked to hear it when these shenanigans were revealed in 2010. But the fact of the matter is that everybody knew what was happening, when it was happening, and Europe as a whole turned a bind eye for not only Greece, but other member states that used these deals to get into the euro zone and are in trouble today as well.

[0]: http://www.risk.net/risk-magazine/feature/1498135/revealed-g...
As someone whose body will also, without an alarm, sleep naturally for 9-10 hours or longer on a weekend no problem, I wonder if you've ever felt looked down upon for this trait by certain people?

I've definitely told people this in the past and had negative reactions ranging from the mild disbelief "You're serious, how can that be possible? I don't believe you" to the outright offended "What is wrong with you (as a person)? Why would you want to spend so much time sleeping? That's wrong and ridiculous behaviour".

I do find it curious how some people tend to get really uppity about this issue. As though one's sleeping habits are reflective of character and morals, or something, rather than just being a natural trait which differs person to person and which one has no choice in. Where does this come from?
It's free if you don't mind giving Google your contact information, which they can easily combine with their advertising data...
VISA Bitcoin debit card
Hi Josh I am an android developer in India, Do you guys sponsor visa?
Don’t Hire a Chief Data Officer Unless You’re a Data-Driven Company
I am an ultra-free-market Objectivist. Still, I think that the Greeks voted correctly.

The problem is: even in a democratic country, you are not accountable to where and how much your government's borrowing. Governments do not produce money; they take it from taxes. Which means: _they_ are borrowing money, and _you_ have to repay it.

While being responsible for debts is a good thing, it only concerns your own debts, not something that was made on your behalf. It's the businesses who will suffer the most (as they are taxable), and they are innocent.
You're correct that specific technologies can drive a small company (Heptares in the UK [0] -- springs to mind). Mostly, though they are business-to-business, rather than the typical view of startups.

[0]http://www.heptares.com/
In the distant future, but as of right now we're focused more on text and getting humans to start participating. The machine learning approaches we're using are getting better every day, and the latest deep learning techniques are showing promise with pictures, so that is certainly a possibility down the road.
VPS / server management all from one user interface / control panel.
Proper Apologies have Three Parts

1. What I did was wrong.
2. I feel badly that I hurt you.
3. How can I make this better.

(yeah it's from a sign on the wall at Jimmy John's)
Eh. I don't think they (ADP) has a right to cut off access. If I am a customer of a financial company and I want to have my accountant deal with them and I give the accountant my password, that is a thing I should be able to do.

I think it is reasonable to disagree with that, but I don't see it as open-and-shut as you seem to.
> And of course he that hath wife and children have given hostages to great fortune.

Applies a little less than usual to biochem PhD students ;)
CRISPR/Cas9 is an invaluable tool at the bench, but it is just a tool. It makes things easier than before, but if you look to the past, you'll see that scientists are cynical people. Attitudes will change slowly (though there are 3 biotech companies jockeying for the ability to use it in clinic).

I think of siRNA and its revolution in biology -- it went from discovery to practical use everywhere in record time, just like CRISPR -- but the direction of research itself did not take that same radical shift. And medicine was improved too, but incrementally.
Would have been much simpler and more straight forward to use a library like Akka instead of manually coding all of this.
Here's the URL for the video itself

https://vimeo.com/72741207
While it's an interesting read, it doesn't really provide enough information to show that this is a good thing. What is the average lifespan of people with this mutation?

Even if Abby lives a normal lifespan we still have too little data we need some randomized samples.

I come from a family of short sleepers. I always go to bed later than my wife and wake up earlier with more energy, this is still the case now that I'm in my 30s, but I have severe health problems compared to the average person my age. Is this related to not getting enough sleep or just another example of confounding.

It would be good to see some real statistical evidence to show that her mutation is even positive.
Thank you. I have long wanted to speak to someone who admits to doing this type of thing as it is very hard for me to understand.

I realize it might be painful to relive a bit, but would you be willing to go into some more detail (it is a throwaway anyway). What did you do, what were you thinking as you did it, and how could someone have reached you sooner to do 1/2/3?
Rather puffed up fluff piece. TL;DR: "a clientelist corrupted state if there ever was one."
A teacher told me in the 70s they used satellite communication as memory buffers, sending data over the air with getting it back a bit later as only goal. IIUC, the earliest form of memory device were doing the same using pressure waves in mercury.
What he did will shock you, but it will also make you laugh
Would the DEC2 mutation be amenable to being given to adults via a gene therapy?
Reactive hierarchal tree using dynamic data
Well said! Good timing too, I'm beginning to sketch out how to tackle this large file set processing that has to stitch together data from corresponding files. The magnitude I'm imagining is such that I can't just read all the files into memory and do the matching, number crunching, and what not against. I like the concepts and terminology in this article. Definitely worth keeping in the back pocket going forward if not diving into it all outright. Thanks so much.
I love that line! But I think a PhD student has it bad, if not worse -- the entrepreneur can watch her venture go under, and then rejoin the labor force with valuable experience and better compensation. The PhD student is locked into finishing her degree at the least, possibly aiming for a postdoc. That's a different kind of hostage to great fortune: your current wealth.
also, it seems to just be reiterating the Title of an article, can it delve into an article to summarize the content of the article despite what the author has titled it?
> Going back to solving other peoples problems feels like a lobotomy.

I've never heard it put quite so eloquently before! You really hit the nail on the head there. Hope you don't mind if I "borrow" that phrase...
In what sense is it a far cry from the Red Scare? Which Red Scare, for starters? There have been two purges of leftists from American civil society in the 20th century, and both of them attempted (from the look of the outcomes) to marginalize leftist politics as far away from the mainstream as possible, to wreck the lives of anyone involved in leftist politics, and to discourage people from those politics due to the fear of the Inquisition turning its eye on them.

Of these goals, the first is no longer relevant (the media keeps leftists and similar out of politics far more effectively than periodically purging the State Department of leftist party members ever did). The second is very real and continues to be accomplished by various police agencies. Because of modern "terrorism" laws, various methods of protest are criminalized as terrorism (mostly pertaining to protests that disrupt businesses, like picket lines or sit-ins), and so protest groups can find themselves targeted by fusion centers, special anti-protest task forces, and federal policing agencies (like the DHS).

Finally, the last goal continues to be enshrined today. Free speech zones and militarized police presence at protests makes protesting a much less empowering act than it was in the 60s and 70s -- imagine if Norman Morrison had burned himself in a free speech pen miles from the Pentagon! Going to a protest now entails locking oneself in a cage and being stared down by beefy, roided-up cops that are actively trying to attack protesters and see protesters as an enemy force. Use of grand jury investigations, fusion centers, task forces, entrapment, and finally, the persistence of social media, makes it hard to join nonviolent groups without the fear of "something" coming up that could ruin you for life. The programming in American educational systems about "keeping Facebook friendly for colleges and employers" supports this self-censorship.

If you look into what is actually going on, possibly by researching some of the topics I mentioned in my last comment, you'll find that modern suppression of non-mainstream politics is indeed comparable to the red scare. The fact that it no longer occurs to such fanfare indicates that such behavior has been normalized on the part of the state.
On which, you can run Linux.
Book Review: ‘Practical Field Robotics’ by Robert Sturges
Gotta love how BI has synthesized both HuffPo and BuzzFeed for the tech news channel.
YQL: query webservices with SQL
Well, his hypotheses about the present are pretty banal: if we continue on present trends, we're in for some tough times. He cites over-fishing as an example.

But of course we aren't strictly following those trends (interview is from mid-2013) particularly with respect to oil. Anybody remember "Peak Oil" and how we were supposed to be on a straight downward slope for supplies? Now the received wisdom is that we'll have a glut of supply stretching into the far future.

This isn't meant as a knock on either Dr. Diamond or on duaneb, just that his conclusions are pretty general and roundish. I find them provocative and appreciate the perspective.
As someone who's made a lot of use of `tail` and similar, this is appealing.

But I don't have a lot of use cases in personal projects, and am unlikely to find a good use-case at work in the near future. What's the 'adoption path' for something like this?

I think a really robust sample data set with example queries (think the neo4j imdb examples) would be a great way to show how powerful and easy something like this can be.
Seattle City Council Passes Low-Rise Legislation: This Is Why Housing Costs Rise
Also it feels like wasting a character on something that only a small number of users are likely going to need.
I think one useful purpose was described by Prof. Mine Cetinkaya-Rundel of Duke at the recent UseR conference. She teaches an introductory statistics class for non-majors. Docker lets her spin up individual virtual machines for each student with all the packages they need for the class without all the sys-admin headaches of getting all the software on everybody's systems. You can see her slides and evaluation of the alternatives here:

https://github.com/mine-cetinkaya-rundel/useR-2015/blob/mast...
Yeah, that's totally true. As another commenter pointed out, it's more-so the case that I only feel qualified to comment on American mentality (and even then, I don't feel especially qualified). This is particularly problematic here since the article pertains to both U.S. and British governments, and the quote itself was from a British author (as another commenter thoughtfully pointed out). I don't rescind my statement, but I definitely acknowledge the ignorance/cultural arrogance that comes with a comment that invokes the context of a single country -- in a lot of ways, it's this very ignorance that I attempt to combat in forums like this, by reading comments like yours :)
This is a nice witticism but I'm afraid it's not very connected to reality.
Python 2 will never die. Ask Kenneth Reitz for example. He says he will use Python 2 forever. There are a lot of companies with huge codebases who never will port to Python 3.
A Detailed Look at Hacking Team’s Emails About Its Repressive Clients
Sosyal İmleme Çalışması
If the language implementation is an issue when doing this, you're doing something wrong.

I'm working on a contract doing this exact thing at the moment, and unsurprisingly the Ruby code that's in the picture is responsible for just a tiny little fraction of the overall latency.

You should spend most of the time waiting on S3, pretty much no matter what language you choose. If you don't, it's not the fault of whichever language you use.

In fact, S3 performance is so dominant in this type of scenario if you do things properly, that if you want to optimize for speed and can afford to risk data loss (or in our case, the clients poll for confirmation and re-upload data in the rare event of loss), it's generally proving substantially better to write to local disk and do uploading to S3 in the background.
I was a regular at that IRC channel back then (for a long time - when it was run from a member's home pc, on EFNet, and the new channel names later on), and was at several of the meets that came from it. The channel had 10-20 regular at most, few enough that I knew all of them by handle and their real names (but I haven't seen any of them for almost 15 years). The whole 'security' angle was a joke, yes it was fun to root some boxes when a sploit hit bugtraq or attrition, but I don't remember anyone got much further than some DoS 'advisories' (at that time). Already then there was more money in scaremongering than there was in actual work...
yes just like 'murica's debt. command economies don't play by any given set of rules. they make their own rules. as long as there is demand in the world for chinese goods, the chinese economy will continue to function.
There's a Mythbusters episode where they make a boat out of Pykrete, it's pretty awesome.
If you're using a cloud hosting, such as AWS EC2, the added expense of Windows is around 30%. Nothing terribly expensive about that.

And you also get credits from Bizspak, that could be used to apply to offset AWS licensing.
An they're unlikely ever to be used by the runtime, because what hints there are are far too vague. Saying something is class X is useless when you don't know what attributes that class has (because they can be dynamically added and removed) nor what types those attributes are.
I think this is a toxic attitude. A friend of mine worked at a bioenergy outfit working on cellulosic ethanol and that was the pervading opinion. For years she tried to convince them that the problem was they weren't controlling their inputs, and finally they did her experiment after she made a statistical argument after a massive DOE setup failed. Turned out they were limiting in a basic metabolic requirement. It's too easy to blame biology when it is often just user error. Bio equivalent of pebkac

They started getting reproducible results, then, major improvements, then the facility got shut down for political reasons and she lost her job.
Surely the statute of limitations on this has passed now and we can know who these legends really were? Perhaps encourage them to seek legal advice about revealing themselves.
Numerical optimization of discrete/combinatorial problems.
That's pretty much how I saw it (Zenefits is similar to a contractor working on behalf of an ADP customer), but there are some issues with that point of view. It could be argued that Zenefits is not only profiting off of their own customers, but also profiting off of ADP's hard work. Basically, ADP is only seeing one revenue stream (the client) whereas Zenefits is using ADP's data to generate income via the insurance policies and other HR services Zenefits resells. Whether that's improper or just sly business sense is a matter for the courts, of course.

The downside no matter what is that the innocent clients are the ones ultimately losing access to both services in this brawl.
"Are you a hacker, Kaz? Tsk tsk!" -- Grade 9 Computer teacher, 1985.

That was because I had used the word in the positive sense: hobbyist, tinkerer.

The hacker-versus-cracker quibble was already festering.
Governments actually produce money from thin air. The "always must have debt money" is a fallacy.
over the past five months Europe has heard way too much from his government about the impossibility of further cuts and way too little about possible sources of new income.

This is wildly untruthful. The last set of Syriza proposals included things like a one-off tax of 12% on business incomes over €500,000 (not unreasonable in either amount or in the context of a culture of corrupt tax evasion), as well as a small rise in corporate tax from 26 to 29%. Creditors rejected these proposals as being 'anti growth'. Now I don't think one can ta one's way to prosperity, but the last 5 years of austerity in Greece strongly suggest that you can't cut your way there either, and it's facile to pretend that taxes should only be considered for their pure macroeconomic effects considering the lamentable history of tax evasion in Greece (which has deep cultural roots in centuries under the Ottoman Empire.

Greece still has to undertake massive reforms, and Syriza's governance has been marked by brinksmanship and overheated rhetoric - but that's what happens when you put people's backs against the wall. It's a generational-scale problem that calls for a long-term rather than the nonsensical series of bandaids that have been thrown at it. I certainly felt that some austerity and fiscal adjustment was warranted, and indeed applying that approach has allowed countries like Ireland to to re-balance the books and regain access to capital markets. But this approach has plainly ceased to work in the case of Greece.

More detail on the specifics of said proposals here:
http://www.economist.com/blogs/freeexchange/2015/06/greek-ba...

Neither the eurozone nor Europe is best served by holding on to Greece. Instead, the European Union needs to come up with a smooth way out of its dilemma, namely an orderly exit by Greece from the euro.

This is about as sensible as adopting a continental currency called the Mark and then trying to kick Germany out of it, or seeking to cure the pain of bad hangover by amputating one's own head. The very word Europe is of Hellenic origin, along with the concepts of democracy, a republic, and the bulk of our philosophical worldview. A Euro without Greece may make short-term fiscal sense but it makes absolutely zero political sense.
Jeff from PipelineDB here. Great suggestion! We've actually created this using sample Wikipedia data. See:

http://docs.pipelinedb.com/quickstart.html
Collecting Docker Logs with Fluentd
@telephoto...

goto one of the following sites:
www.bbc.com/news, washingtonpost.com, huffintonpost.com, reuters.com, theglobeandmail.com

On those sites, find any text article that's medium+ size in length, and submit the article (not the home page of the news site) to gist.

You should see that it's not just reiterating the title.

On many sites it's quite buggy, and what you're seeing is likely the result of gist either a.) attempting to gist something when it shouldn't (like say bbc news home page), or b.) attempting to gist when the scrape/parse failed and there was too few or poorly parsed sentences.

We do extract the html title and stick it in at the top of the page as a reference, but that title, like each gist, is editable by the community, and serves only to act as a jumping off point.