skysight-inc/HackerNews huggingface dataset:
I think there's been a lot of research/grants for working on population genetics; specifically, sequencing genomes and genetic expression profiles of patient pool of a particular disease (e.g., schizophrenia) and comparing it to the general population pool and clustering to find particular groups of genes that might be responsible for a particular disease.

Likewise, there are state agencies and startup's alike working on pre-natal genetics screening that basically tries to identify from pre-natal samples particular markers (SNPs) known for Down Syndrome, Tay-Sachs etc. Not to mention people who submit their samples to find interesting markers from 23andme.

I'd love to hear more from folks in the field what they think the next big application of computational biology, clinical genomics will be. Obviously, there has been a lot of mixed opinion regarding both on the consumer side (FDA banning 23andme from making broad statements of users having a higher-probability of cancer due to outdated and controversial data) and research side (has Human Genome Project since its completion in the early 2000's yielded a significant gene to target compound to drug on the market?)

More practically, Illumina (https://www.google.com/finance?q=NASDAQ%3AILMN&ei=af5xVYHoB4...) has more than 10x in the past 6 years, riding the wave of demand and growth of next-gen sequencing technology. If Cloud Computing is hailed as the sequencer's of the next phase in the biotech revolution, what stocks should I buy now to take advantage of it?
Interesting - can anyone provide an in-depth comparison to LFE [1]? From a quick look, it looks like Joxa is more similar to Clojure than it is to Common Lisp, whereas LFE takes the opposite appoach.

[1] https://github.com/rvirding/lfe
This. Bitbucket all the way.
> Probably should learn Git with my next project...

Do it. And I'm saying that as your fellow .net guy.

The only downside is that you will start hating TFS at work for being so God damn dinosaury afterwards ;)
(edit. Had the wrong link)

The NIH has documented guidelines [1] on genomic data sharing that may be of interest.

1. http://www.ncbi.nlm.nih.gov/projects/gap/pdf/dbgap_2b_securi...
Personal anecdote time.

Have been using Linux off and on since 2000. Later my job required .NET, so got into the MS stack but still kept playing around with Linux for things like IRC bots etc.

Then at work there was a major open source push, and we did a big project using Drupal. Used Eclipse and Netbeans(mostly this), deployed to Ubuntu server for dev and RHEL/CentOS for prod. I can sling Vim but never like Emacs(you need a second nose to type some of the shortcuts!)

I was DevOps because only I in the team had Linux experience beforehand. There were some good things but C# vs. PHP was no contest as was VS vs. Netbeans/Eclipse.

Ubuntu vs. CentOS/RHEL was quite annoying because there were small meaningless fragmentation differences like Apache daemon as httpd in one and apache2 in the other. Really? Why? I found myself raging at them sometimes.

After doing that for a year, back to VS and .NET and it felt like a relief. I liked the power of nginx though which we used as a reverse proxy for the Drupal project.
Isn't this a concern with most APIs? (Even paid ones can shut down, like Ordrx recently)
Audio-only chat would be nice - we use skype, and audio only is our default. If there was a way to make the notes area be a code editor, or have two tabs - one for notes, one for code, that would be really nice. We use google docs a lot, but its terrible for code, so sometimes we use collabedit. Finally, it would be really nice if the notes/todos could integrate with something like an issue tracker or project management tool.
Having interviewed with one of the companies currently listed on the jobs board, I could easily see how "having a discussion related to job placement at the company" could lead to negative feedback, and dissuade potential applicants.
> keep 2.4GHz as communications only

communications and heating food
Apple Planning to Change 30/70 Pricing Formula for In-App Media Subscriptions
Leading Architects Defend Hated Buildings
Aware of what?

I often find people in their 40s' to be deeply troubled, tired, and grappling for power or ego.

Anecdotally I have encountered more people in the 50s-90s range with a calmer, wiser, and altruistic awareness of self and others. I imagine it has something to do with the thought of mortality nullifying their materialistic or egoistic pursuits, and some sort of realization that we're all here together on a big rock hurdling through space so maybe baking a batch of cookies for friends is a good idea worth spending time on.
Good point. Now, the question is, are the annotations available for download? If not, why bother? Annotations are useful if they can be saved and moved (just like bookmarks).
Ah, ok. That makes sense. Confusion resolved!
"And that's the problem I see artificially constructed meal replacements running in to--if you do the best you can based on the science available, that still may not be enough."

This is an excellent summary. It's not about a "fad" or being "organic" or something like it.

Nutrition is a very complicated subject and while science has shone a lot of light on the subject we still don't know a lot. So sticking to the "tried and true", that is, what people have actually been eating is safer.
Thanks eggie for your insight. Was wondering if you can give more specifics as to what you think are the challenges in going from a human genome assembly to drug discovery.
This assumes a flaw in the cars algorithm to be travelling too quickly at an upcoming intersection - or a pedestrian breaking the law by jay-walking or crossing during a "no cross" time.

Let's give it the most realistic scenario of a blind-turn intersection with an obstruction such as a bush make it impossible to see the sidewalk on the right-hand side. The two pedestrians in question are a grandparent and their grandchild crossing without looking both ways for their safety.

Is there oncoming traffic? Is there an empty sidewalk to drive on? Can the car make an attempt to brake as safely and quickly as possible and sound the horn to alert the pedestrians to get out of the way? Is it safe enough to perform a handbrake turn? Is it safe enough to perform a bootleg turn?

Before asking which pedestrian the car chooses to hit, I would exhaust all other available options to prevent such a scenario from happening in the first place.
Too bad I don't run @shit_hn_says.
He actually loved writing for ESPN. His page 2 column was renowned. He actually wrote one of the most eloquent and accurate statements on 9/11 the morning of in that column.

http://proxy.espn.go.com/espn/page2/story?id=1250751

He was an excellent sportswriter, and an even more extraordinary political one. His influence is now gone in Rolling Stone, but he gave them their entire ethos alongside Jan Wenner for years.
the dropping prices of RAM lead us to re-evaluate what we consider "data that fits in RAM". at 10Gs it's just more economic, and even if we go up one order of magnitude, the serving speed of redis still makes it economic for a lot of workloads.
We have a "TE" shortage and a "SM" excess.

The math field is being cannibalized by tech and finance, and the only sciences doing at all well are those with direct applications to healthcare or war materiel.

So if you throw the existing 'M' in with the 'T', and replace it with an 'H' for Healthcare, then fold the remaining part of the 'S' into 'M' for Military, we might have a "METH shortage".
The most mature and powerful Python tool for inlining CSS is https://github.com/peterbe/premailer

I started it but it's been actively maintained by over 30 coders over several active years.
Yes I would agree the core unix system macs use is fine but gui and the rest of the god awful stuff apple have added in a jerybuilt way.

I have totally fallen out of love with apple nice to look at shit to use for profesionals.
Eh, saturated fat isn't great, but it isn't as terrible as we used to think. Check out: https://en.wikipedia.org/wiki/Saturated_fat#Association_with...

To me the problem is the sugar content. It's easily double, even for a large man, and almost triple for a small woman.
Sure, the two teams played out a tournament to get to the finals. That required lots of skills, talent, hard work.

But are you saying that the teams that didn't make it the finals just didn't want it bad enough? Worked hard enough? Were talented enough? Or lucky enough?

Maybe you can look at it as it's pretty random how the players on the respective teams ended up there compared to hundreds of thousands of potentials drawn from the NCAA.

Because one wrong twist of your ankle, one indulgence of a pizza from a commercial entity, one bad grade, and you could easily be on a different path.
Thanks for all your hard work! I use Nodejs tools every day too and it makes my job easy.

Nothing else even comes close - not WebStorm, not Sublime and not Vim or some hodge-podge of other tools.
He had a remarkable sense of worldview from a young age. At 17 he wrote:

"As things stand now, I am going to be a writer. I'm not sure that I'm going to be a good one or even a self-supporting one, but until the dark thumb of fate presses me to the dust and says 'you are nothing', I will be a writer."

His views changed a slight bit, but not much. He was truly a person who knew himself.
I wouldn't even consider that my doctors' business. It's your business, full stop. Your doctor is a contractor whose job it is to help you interpret the results, same as a medical device.
The premise is that the goal is sufficiently hard and the reward is the incremental advancements. If at the end, the goal is achieved, it's simply cherry on top. If the goal is not achieved due to unforeseen circumstances, it doesn't mean that the life was purposeless as you can very well see the progress made by tracking incremental achievements.

As I said before, its all down to wiring.

Also given the advancements in medicine and increase in life expectancies, I think the chances are a lot many people will live to 60+ so planning life for the worst case may not be optimal.
I'm there with you. This thing is so complicated that it might be hard to just do an easy to follow tutorial. I've been tinkering with it for a while in a robotics application, and progress is slow (steady, though). One of those fields where the roads are still unpaved. :)
Money doesn't vanish into a black hole. It flows.

Those 8 million will no longer have to worry about feeding themselves, educating their children, paying their rent. They can create. A % will create businesses to take advantage of the money flow, supporting themselves and their communities, paying taxes, jobs, export.

Over a single generation you could move from 5% literacy to 95%, for 8 million families. That's a lot of kids and a lot of creators. Fewer babies next gen too if history is right.

Those 8 million will essentially have their greatest fears and worries removed and replaced with joy and freedom. Just imagine the possibilities.
Indeed, it's a new information source pretty much untapped for now.
More or less this. Row = HASH key, sorted sets for secondary key indexing, and also for iterating primary key entries. I've built an abstraction layer on top of redis to automate all that and it works rather well.
It doesn't matter what coping techniques they used. What matters is that they accomplished the task in a way that showed increased discipline.

Additionally, the marshmallow study isn't the only research that shows this effect.
I also keep thinking I should port it to javascript, so it can be run in a browser. Just think on those interminable waits at the airport you could be playing Empire!
Because Google has mapped out the roads to a very specific level; this allows them to use sensors in the cars that don't have to have the fidelity of human eyes etc. As Google's maps become out of date, they need to be recreated or checked. Their system won't scale...
I don't think you need to do this for the same family next year.

8 people per year * 20 years = 160 Million people.

Also, the example was a family of 4 which would bump it to 640 Million.

PS: Those 7000 million people include plenty of people that are doing just fine.
I misread you, I thought you meant working two jobs, not working and searching a new one.
I write about interviews and have made $2 to $100 every month. I plan on writing about other subjects and maybe doing youtube solution to interview questions.
http://kelukelu.me/interview/

I sold art through redbubble. I've made around a whole dollar. But at least my art skills are getting much, much better.
http://www.redbubble.com/people/kelukelu?ref=account-nav-dro...

The goal of both is to improve my writing and drawing, but it's nice when people decide to support me. :)

If I were more serious then I'd buy rental property.
How to Read a Technical Paper
Name: Debugging Design

Elevator Pitch: Ebook on UI/UX Design for Developers

Stage: 60% of content complete. Creating video content now for premium tier.

Would LOVE for more user feedback, specifically anyone interested in telling me what they struggle with design-wise & what they would love to see in a resource.

hello@angelasmith.com.au
Ask HN: Anti-drone, anti-surveillance tech for the home?
Although it's a somewhat unsolvable program and we should all get used to living in the panopticon, etc, etc, I'm excited by the evolution of possible countermeasures discouraging the sort of nuisance surveillance so many people worried about drones, CCTV, wearables, etc find concerning.

So a simple use case: Someone flies a drone past each of your windows every night looking to film as much of you in compromising positions as possible. Is there any solution that would be feasible to stop this, beyond just blacking out your windows?

This got me thinking about it: http://www.dailydot.com/technology/cyborg-unplug/
If they need to bribe people, they could hide that in some "Administrative fees" budget item. They could still disclose how much they spend on projects and aid.
Even today, years after that show has long since ended, talking about tech that isn't necessarily relevant any more, it is still entertaining and worth watching for anyone interested in the field or its history.
You're sort of falling victim to the rules of the current game (US entity owning subsidiary in xyz location) I was working at a higher level and rejecting the notion that a company no longer needs to pay taxes on profits simply because they're outside their borders. The Chinese government can tax worker salaries and levy a consumption tax on goods and services sold into the production. The German government can levy a GST too. And Apple, where applicable, can deduct those taxes before calculating profits. So conceptually that's the cleanest way it should work (same for a German or Australian company. No U S A U S A thing going on here)
Andreas Gal is leaving Mozilla
"A program that gives water to the on fire creates a disincentive to not be on fire through stopping, dropping and rolling."
8/7000 is 0.11%.
> I wonder what Hunter would have said about the difference between fear of missing out vs staying for excitement of what might come.

This is really the way I mean it. Find the ninth path, even if it takes awhile to get started. That's where you might miss something.
I'll (sadly) take the over on that.

I'll bet you $1k that fully autonomous cars will not be:
(1) legal to ride on at least 90% of public roads AND
(2) available for sale to the general public AND
(3) for under $250,000 in 2015 dollars AND
(4) in the state of California AND
(5) on or before June 5 2020.

Deal? (If I were richer, I'd bet more, in order to up my chances of being happy either way. I want to lose, but don't think I will.)
“We had inspections before the work began, and found mortar that had crumbled, but the stones hadn’t moved. It was truly overengineered. It is so strong.”

UK: I use bridges and viaducts of this vintage everyday - train bridges, canal towpaths, road bridges. They over-engineered because of the fear of failure.
He was one of my childhood programming idols lo those many years ago; cemented after reading the original Programmers At Work.
Show HN: Speedtest command line
Sure, but if the lead time is more than about 12 hours, it doesn't matter how long it ACTUALLY is, it's too long, people are dead before whatever $essential gets to them.
Optimizing Redshift Performance with Dynamic Schemas
I've been having Soylent for breakfast for 6 months. Super easy, I just put a scoop in a bottle with some protein powder, shake and drink. Tastes fine. A very easy way to get 500 calories in the morning between gym and work. Sometimes I'll do half a cup at night if I'm hungry. It's nice to know that there's a quick meal option that's perfectly balanced nutrition wise.
Put 20% of your salary into an ETF. Check back in 5 years time.

Alternatively, write an ebook.
Doesn't using the chad as bait for fishing simply put the pollutants in other waters? It seems a little shortsighted but maybe I'm not understanding the full story.
I think the real answer to this sort of question is: Who cares?

There are tens of thousands of people dying every year in very real car crashes, plus probably an order of magnitude more suffering life-changing injuries, and self-driving cars have a huge potential to cut way down on that. Meanwhile, situations like that virtually never happen - maybe like once a year in the entire US. If they can eliminate even 10% of the actual accidents, then they could run down both pedestrians in that imaginary scenario, and still be way ahead.

It may be fun to think about ethical dilemmas like that, but they are fantastically rare compared to the huge numbers of perfectly ordinary crashes that happen every day. Let's fix those, and worry about the rare one-offs after we've reduced the accident rate by 95%.
The Torturous World of Powerpoint (2004)
Firefox Bugzilla: Remove Pocket Integration
I just turned 40 this year. I have 7 failed businesses behind me and one that is still alive, doing well.

One thing I have noticed is that a better understanding of how the world ACTUALLY works has been a huge help in avoiding the many pitfalls that await the intrepid explorer. And since there is no manual that explains all of this, you can only really get it through hard experience. And to make matters worse, once it's internalized, it just becomes part of your background thought process, making it difficult to explain to others because you hardly even notice it's there until you see someone about to make a huge mistake.
Hermann Zapf was the creator of AMS Euler, Optima, Palatino, Zapfino, Zapf Dingbats. He was also known for his collaboration with Donald Knuth.

His death is not widely reported yet so there are only a few sources:

Wikipedia gives as source notable calligrapher Julian Waters. John Stevens on Twitter[1] . Hoefler & Co "Hermann Zapf passed away last night. He was a giant." on Twitter [2].

[1] https://twitter.com/calligperson/status/606867036816482305

[2] https://twitter.com/HoeflerCo/status/606865724158709760
I got frustrated wanting to check "internet speed" on various servers so I made a command line client for speedtest.net. If I've learned one thing from this project it's that a "quick hack" can snowball so put more thought into the design upfront than seems necessary at the time.

In particular I think I struggle with the "go way" so any suggestions with creating more idiomatic code would be awesome.

Thank you!
This man legally changed his name to avoid paying an airline fee
Teespring (YC W13) Is Hiring a DevOps Lead
WHAT DOES OUR TEAM DO?

The DevOps team focuses on creating high quality automation and deployment systems with scalability and reliability at the core. We have multiple engineering sites: USA - SF, KY, RI, UK - London, and India. The DevOps team creates continuity between all locations and boosts the efficiency of our operations.

WHAT IS THE JOB?

The job is to lead others with the ability to get your hands dirty as an individual contributor. Operating in a technology environment with strong scripting (Ruby, Python, Bash), 100+ Linux Servers, Cloud Hosting (AWS), Configuration Management Tools (Chef, Puppet, OpsWorks), Postgres and MySQL, and ROR web app frameworks.

We need someone to take our DevOps organization worldwide this year. Your objective is to reduce any engineering inefficiencies by building out 24/7 support for multiple engineering sites; to start: a migration plan for moving from Heroku to AWS, redundancy for key systems, DB health optimization and scaling, a business continuity/disaster recovery plan, five minute code deploys/rollbacks, and add support for isolated engineering environments (Docker/Vagrant). Additionally you’ll work hand in hand with the developers as we move into a micro services architecture (SOA), building out the infrastructure so we can decouple and scale.

We want people with the ability to bring new ideas to help drive innovation. Our employee philosophy: IDEAS - Innovative, Deliver, Empower, Authentic, Scrappy.

If you are successful in this role, a year from now you will:
Execute on prioritized roadmap, building out a high efficiency devops structure
Solved redundancies, optimized efficiencies, and made significant progress to scaling the environment
Lead, train, and mentor team member(s)

WHAT DO WE NEED?
Leadership of a team/environment managing code and architecture
Individual contributor who can can code, create high level strategy, and migrate systems
Ownership of projects and collaboration with multiple engineering sites
In-depth knowledge of DevOps tools, AWS, coding/scripting, disaster recovery, scaling, servers

WHAT DO WE OFFER?

Happiness is just as important to us as hard work. All startups in San Francisco offer the same perks, but what makes us different is our desire to completely change how the world thinks about apparel and custom commerce. That being said, here are the benefits you will receive:
Working with talented, collaborative, and entrepreneurial teams
Medical, dental and vision insurance for you, your family, or pet
Unlimited paid time off and 9 paid holidays
Generous stock options
Free catered lunch and dinner daily
Fully stocked kitchen with drinks, snacks, and bar
Training, career development, and tech talks/ meetup hosting
Fun SOMA office with easy access to Muni, Bart, and Caltrain with commuter benefits
Macbooks and Thunderbolt monitors
Social activities, office happy hours, concerts, game room, and endless free t-shirts!

Please email your resume to ashley.hearn@teespring.com to learn more!
So your answer to my hypothetical question of what an algorithm should do in a situation where whatever the outcome a life will be lost, is to say that this scenario will never happen without a flaw in the cars algorithm? That seems very narrow minded to me. Let me put it this way: When all your other available options are exhausted what should the choice be?
That may be true, however OS X users actually spend money on apps.
There's all kinds of toys for that:

http://www.signaljammerblockers.com/
.... true. So they deprecated the methods for it in the API, but it is right there on the page. Strange.