skysight-inc/HackerNews huggingface dataset:
There are economic forces at play that actively discourage pharma from trying to identify who will benefit most from the drug. First of all, there is a huge priority on being first to market. They stand to make hundreds of millions if their drug is approved before their competitors, and they can be the sole option for even 6 momths. Doing prolonged preclinical research to delay registration trials and FDA approval makes no sense to them. Secondly, the fact is that they make more money if we just give the drug to everyone. It takes 3 doses or so before doctors can work out if a drug works or not. So if we give 100% of cancer patients at least 3 doses, they profit more than if we give it to just the 30 - 60% that could benefit the most.

So although you are right that encouraging or forcing companies to come up with companion biomarkers that predict efficacy is a good way to reduce cost, in reality it is not so simple.

The hype about these latest immunotherapy drugs is so massive (and much of it is justified) that pharma has everyone over the barrel, they will charge the earth and get away with it.
I know that - but the previous comment made it sound as though it did mean immutability.
It's too early to cry wolf yet

Wrong. It's too late to automatically assume they've changed their game. They have been making some impressive moves lately, but that doesn't mean they're suddenly trustworthy.

there's not even an obvious way to get from here to "extend"

just look at all the nonstandard SSH authentication methods that exist across networking devices.
Jimdo will drop support for Portuguese speakers [Portuguese]
WikiLeaks offers $100k for details of Obama’s trade deal
Can you speak about where you started with your rates, why you started at that level, and how you progressed them to where you are today?

I'd also be interested to know the length of a typical client engagement.
Catching Fire, by Richard Wrangham, is a pretty good read for those interested in the impact and importance of cooking in human evolution. I really enjoyed it.
Either the proportion of people with a WSJ subscription, or who up vote the title, is unusually high here.
They tried to extinguish the web, and failed. That is enough to not trust them for a long while still.
> The amount of times where defining a partially applied higher-order function is the best way to solve a problem is nonzero, but still really really low

I disagree. Once you learn to use partially applied higher-order functions, they end up being useful everywhere. I'm using them right now in Scala for my day job, and my code is not particularly fancy.
The 10 best ways to kill time in the Witcher 3
Nope, extensions are fine (as per about:addons-memory)

From sysinternals process explorer I see working set 1.6GB and Virtual Size 2.6GB with ~200 tabs open. Don't understand why the virtual is so big.
As far as I know, whatsapp had very few employees (about 50). I wonder how many of them were non-technical
Windows support for driver development is lightyears ahead of everybody else. Picking up a library or two doesn't make it a variant of anything.
Sorry, but there is imho to little regulation going on here. The market seems rigged against patients - esp. patients with terminal (or at least grave) illnesses that are pretty wide spread. These people are hey are prone to be exploited and there are enough of them. Mostly pharma does not dev drugs for wide spread illnesses that mostly occur in poor countries for example. Or grave illnesses, that only affect very, very few people.

But dev a "new" cancer drug and you got your license to print money (lot of people get cancer, a lot is payed by insurance, and people and their loved ones want healing).
Elmer Fudd, everyone knows that.
Are there any similar tricks for getting around the Economist paywall?
I was under the impression the `SO_REUSEPORT` implementation on Linux was rather broken, as evidenced by HAProxy's graceful reload still dropping packets[1]. I'm curious as to why Nginx has implemented this when you can design your Nginx config around the problem while not encountering the broken implementation.

[1] http://engineeringblog.yelp.com/2015/04/true-zero-downtime-h...
Does it hold context for subsequent questions? For example can you ask "what city is the Brandenburg Gate in?", "which country is that in?", "what is its population?"
I came here to say the same thing. IANAL but it looks like if Apple wanted (which they probably don't) they could have them charged under the computer abuse and fraud acts, even if Apple doesn't act the DoJ still can. I can understand the researcher's desire to follow the trail but in attempting to unmask the criminal did they themselves not become one in the process? This is "Ends justify the means" type thinking which is really dangerous (Patriot Act anyone?).
Yeah good luck in Ukraine. I see the pro Russian 'rebels' have gone from claiming the Kiev government are nazis to claiming they are 'miserable Jews.' They seem a bit confused in their messaging. If it was just propoganda it would be comical but sadly the Russians seem to be sending troops and weaponry also.
I'm missing your point. Most diseases is characterized that way - lots of people get them, healthcare paid by insurance, people want healing. Cancer is not special.
Uber poaches 40 people from 'partner' Carnegie Mellon
This is excellent. Now I won't have to rely on that terrible, terrible program PuTTY.

As for those who are claiming this is a harbinger of Microsoft trying to take over SSH... well, get those tinfoil hats ready, kids. Looks like Nadella's Microsoft is willing to play nice in a wide variety of arenas, so you'll have all kinds of things to be foolishly terrified of.
I don't know what press coverage has to do with the fact that they're trying to scam people out of a few grand.

They’re saying it’s going to cost $50,000 to do this. They currently have less than $1,600 committed. They get that money no matter what. So what are they going to do when they get a $1,600 deposit? Have a nice dinner? Make their car payments for a few months?

There is NO reason for a legitimate entrepreneur to use flexible funding. You should ask for what you realistically think the bare minimum is and have stretch goals beyond that. Anything else is one breath away from theft by deception.
> I can't believe so many people see reclining as rude, it's the design of the seats. If the person in front of you reclines, recline your own seat.

That the seat is designed to work in different positions has little to do with whether or not it is rude to use some of those positions. Rudeness is in general situational. An action that is fine under some circumstances can be rude in other circumstances.

For example, my home theater is designed to make very loud sounds. Are you going to argue that this means it can never by rude of me to listen at top volume?

My digestive system is designed to expel noxious gases. Do you think that justifies farting in crowded elevators?
When you visit the link you would see:

>"The term disorder is often considered more value-neutral and less stigmatizing than the terms disease or illness, and therefore is a preferred terminology in some circumstances"

Also, regarding mental disorders the link says:

"In mental health, the term mental disorder is used as a way of acknowledging the complex interaction of biological, social, and psychological factors in psychiatric conditions."

And the wikipedia entry even touch the point I was referring to:

"On the other hand, by emphasizing the medical nature of the condition, this term (disease) is sometimes rejected, such as by proponents of the autism rights movement."

Finally the link starts the section with this phrase:

"In many cases, terms such as disease, disorder, morbidity and illness are used interchangeably.[3] ##There are situations however when specific terms are considered preferable.##"
(emphasis is mine)
I dunno, there's a good moral argument for giving a fairly mild ration of shit to somebody who insists on using a little experience to draw sweeping conclusions. It happens so commonly and so persistently that I do think a little bit of applied loss of face might be helpful. Hot stoves and all that.
A plausible outcome for this technology as well.
Following Facebook's story on PGP, I see I had missed that Facebook directly supported Tor since last fall. https://www.facebook.com/notes/protect-the-graph/making-conn...
Because misdirection. Who else have access. The FSB?
One of the contributors of REUSEPORT support is a long time Dragonfly BSD developer. No broken Linux implementation there.
In addition to the comments already here, I think this comes down to trust. Which companies do you trust? Which CEOs do you trust?

Eric Schmidt: "If You Have Something You Don't Want Anyone To Know, Maybe You Shouldn't Be Doing It." [1]

Mark Zuckerburg: "They trust me — dumb fucks." [2]

Tim Cook: "I’m speaking to you from Silicon Valley, where some of the most prominent and successful companies have built their businesses by lulling their customers into complacency about their personal information,” said Cook. “They’re gobbling up everything they can learn about you and trying to monetize it. We think that’s wrong. And it’s not the kind of company that Apple wants to be." [3]

Tim Cook: "Our business is based on selling products, not on having information about you. You are not our product." [4]

Tim Cook: "We take a very different view of this than a lot of other companies have. Our view is, when we design a new service, we try not to collect data" [5]

[1] https://youtu.be/A6e7wfDHzew

[2] http://gawker.com/5636765/facebook-ceo-admits-to-calling-use...

[3] http://techcrunch.com/2015/06/02/apples-tim-cook-delivers-bl...

[4] http://www.macrumors.com/2014/09/15/tim-cook-on-privacy/

[5] http://techcrunch.com/2014/09/15/tim-cook-holds-firm-on-imes...
If you google "Avastin breakthrough" (remember, we lay people have far more time with Dr. google), its still touted as this miracle drug, and is even being pushed as a treatment for non colon cancers of which there is little evidence it does anything... And remember, there are oncologists / doctors who lend their name to the company PRs... Its so sad to think someone would spend $20k on a useless drug, when $20k towards supportive treatments would go such a long, long way for quality of life :(
I know there are genuine big steps forward. The cancer that killed Terry Fox for example is so treatable now. And there are good and effective drugs out there, and some that are bullshit. But from the perspective out here, its difficult, sometimes very difficult to tell the real breakthroughs from marketing hype.
How Well Do You Know the Decade's Biggest Data Breaches? [Quiz]
For small home machines, the storage cost is minimal. All my home machines are mirrored, for around $100 each. Its saved me several times.
I always used openssh under CygWin on Windows, not a problem but I preferred not to use Windows at all.
>What I don't understand about any of this is why anyone wouldn't just either move their project to Github or self host.

Personally, I like their download stats:

https://sourceforge.net/projects/apng/files/libpng/stats/tim...

But generally, why would I move if I never had problems with the service?
The retail (POS) experience is still inconsistent, frustrating.

Some POS always require a signature, which I don't understand. Some POS allow "swiping" at any time, others fail unless done at just the right time. Some POS are just flakey (please try again, while the line behind you glares).

Apple needs to publish a POS-side Human Interface Guideline (to compliment the iOS side).

https://developer.apple.com/library/ios/documentation/UserEx...

They also need to create an exemplar POS for others to copy.

And since we seem stuck with the self-service checkout, Apple needs to fix that experience too. Currently, they're two different UIs bolted together, both terrible.
The trick is to paste the url into google and then click a link to it. Note to other duckduckgo users, it has to be google.com, not encrypted.google.com.
> Implying they MITM our messages and can censor them.

Their ability to do this has been known for a while - see past HN discussions:

- Https URLs posted in private Skype chats visited by Microsoft https://news.ycombinator.com/item?id=5704574

- Skype and Microsoft man-in-the-middle chats to give targeted ads https://news.ycombinator.com/item?id=7369163
If this is a windows install, do as you would normally do for a spyware infestation.

1. Go through installed programs and uninstall any that you don't want/ didn't know about. Google any you have questions about. (Clicking on date in upper right will sort from newest to oldest.)

2. Get rid of Audacity. We can only assume that this binary is infected as well as the installer.

3. Run something like malware bytes. Do be careful to get the right installer, as the website has many misleading links. Run this.

4. Install in browser: ad block edge for Firefox, or ad block plus for chrome or safari. Quit using IE if you use that.

That should take care of 99% of all problems on your windows machine. I have no clue if you should or should not be worried regarding bad binaries from scamforge. I haven't analyses the binaries.
This is a pretty inaccurate description of life in a game studio.

Games are incredibly unpredictable. Even after Minecraft blew up in popularity, there were tons of risks. Plenty of games have blown up, only to fall off in popularity quickly. Minecraft has been far stickier than most games, which is an easy thing to acknowledge in hindsight, but a pretty challenging thing to predict.
Shadow Kings Hack Tool No Survey
Something that I think gets missed often from these discussions is the idea of different definitions of 'senior' in different contexts. If you're working at Google on search algorithms, it doesn't matter how good a communicator you are, if you aren't technical enough to understand the work and think about how to improve it, it's not much use.

Conversely, if you're a brilliant architect but aren't great at being very pragmatic and hacking stuff out, you might not add much value to a lot of smaller webshops.

So someone who would qualify as senior in one place, wouldn't be very effective elsewhere.

And as developers, we can try and identify our own interests and skills and find work that fits these.
Roma – Free WordPress and WooCommerce Theme
Sourceforge's mirrors are a complete miss-use of the term mirror. A mirror should be an exact copy of the source and should be approved by the original project, which I doubt any of these 'mirrors' are.
The kerberos described in http://web.archive.org/web/20140222133423/http://www.network...?
Shame on you guys. Perpetuating the notion that "experts" can consistently beat the market is criminal. Instavest appears to be a typical sleazy financial business capitalizing on misinformed customers.
Terrible? Concerns over how to obtain it aside, what's wrong with PuTTY?
Is it really so much harder to search for "django framework" instead of "django unchained" or "django guitar"? When you type in "django", DDG will suggest some searches to autocomplete as well. Is the performance benefit of personalized searches really worth it, compared to refining your search technique in small ways?

Personally I prefer DDG simply because the bang codes are so convenient.
> + "Run your own infrastructure" is currently a pipe dream for what is 99.9% of people.

Or not even a dream, because those 99.9% prefer not to run their own infrastructure even if it's easy and cheap.

However, "local apps" (ones which don't require infrastructure) could be appealing if they could achieve parity with the enormous-backend apps.
I remember back in the day pre-Microsoft when Skype was unable to do that because it had point to point encryption. Then Microsoft purchased them, killed the Skype P2P infrastructure which was a massive cost saver for Skype and instead had it use standard servers.

People have claimed, without much evidence, that the NSA helped finance the purchase for Microsoft in exchange for making Skype easier to monitor but so far as I said nobody has solid PROOF of that, just speculation.

But I will say what Microsoft did made little logical sense. The whole point of Skype was to make running a network inexpensive and scalable, Microsoft's changes made running Skype much more expensive (and what company WANTS a product to cost more to run?).
The Economist is great. I highly recommend a subscription.
Exactly. America simply got caught.
DO by InVision
Well of course. Tailored ads just make sense to companies because it increases click/conversion rates.

I would rather not be convinced to buy things I don't have a need for. Thus, I don't see how more effective ads are any better for me.
Not sure if 'kids' is the right address for people who remember the bad old Microsoft ways.
It took them until the 21st century to do this?
Three spring to mind: Michael Dell, Steve Jobs, Bill Gates
What if two people pick the same project independently of each other, work equally hard, and only one comes out successful. Did the one that did not come out ahead not work hard?
carlige remorcare craiova
How exactly do you mean that?

The total count of devices supported by Linux exceeds that of any other OS, based on statements from Greg KH and others.

Windows has an edge in some areas of proprietary desktop hardware (see Linus's infamous but richly appropriate "fuck you, Nvidia" comment). But that's superiority in a narrow (though highly significant) niche.

As desktop falls in significance, that edge and leverage will be less valuable.
This faggot delivers a blistering speech?

More like a high-pitched whine, like a woman.
Old school and served over HTTP, making it not that hard for someone to MITM you and give you a backdoored client when you download it.

Don't worry though, the page has checksums you can validate your download against! Except those are also served over HTTP.
New Journal of Cybersecurity launched
>Any place large enough to need a SIEM wouldn't balk at licensing a server or servers if it was explained to them that you wouldn't need yet another highly privileged agent running on a domain controller.

You'd be surprised at how many organizations will have the management spend $1.5m on a SIEM but the engineers refuse to use another Windows license.

There are ways to collect Windows logs. It's just not as easy as collecting syslog. And syslog doesn't need a user account to collect logs.
Incognito mode, but if you read it a lot consider a subscription.
Ill be frank as well (junior dr here). They buy you lunch weekly, often for the whole establishment (your practice, the hospital, etc.). In the ye olde days they erherm..'sponsored' vacations for doctors to for example, Hawaii. It could be like a 1 week vacation, where they'd require you to spend half a day learning about their drug and going through their marketing spiel with you. In return they'd host your flights, accomodation and food (trust me the food is good).
Another victim of failed sarcasm tag parsing.
That change came in a time where Skype ran increasingly often not on PCs but rather mobile devices. And what tablet or smartphone user WANTS a chat application to consume excessive CPU and bandwidth while running in background?

That's the official version, anyway. You may choose to ignore reasons giving by the people who made the change, of course. The infrastructure on which Skype was built relied on most clients being PCs with decent internet connections and CPU to spare. Something that's increasingly not true in today's world.
Wiresharking for fun and profit
Making an Untraceable AR-15 ‘Ghost Gun’
This was a really good read, although it did come off as a bit 'over positive' towards Elon & Tesla.

Thanks for introducing me to waitbutwhy.com I like the concept but I've not seen it before.
I mean it as a driver developer. Its trivial to do things that are difficult or impossible anywhere else. The environment has good support for driver developers.

I would dispute the 'total count' argument. Windows doesn't require rebuilding the kernel to get device support for some vendor's hardware. The total count of Windows machines actually succeeding in supporting any given device could be many times higher.
All the configuration is stored in the registry so it's difficult to hand-edit or export/import. Also it mashes a terminal emulator together with an SSH client so if you want one you're stuck with the other.
Dumping American Junk Bonds in Japan
An SSH client is also included with Git for Windows, since it includes MSYS, plus Git needs to connect through SSH.

There's also Cygwin, which comes with the OpenSSH server in addition to the client. For a preconfigured Cygwin when I needed it, found Babun to be useful: https://babun.github.io/
https://www.google.com/search?q=College+Dropouts+Thrive+in+T...
Having spent 6 years as a fully licensed Financial/Investment advisor as firms both large and small (independent), I can say that while I think this is a cool project, marketing it towards investment advisors likely isn't going to get much traction. This is because 99% of advisors (in the US) already have access to tools like this, except much more in depth and integrated with their trading systems. It's in every broker-dealer's (the companies whose investment products the advisors are selling) best interest to provide as much sales support and tooling as possible to their registered reps, so many of them provide things like this free of charge.

Aside from that, unless this has been vetted and audited by FINRA or a registered CRCP, the chances that any compliance officer (which every RIA is required to have), are virtually non-existent. I haven't dug into the platform to see what type of guidance you're offering/presenting, but you need to be really careful about what advice you give or state that you give. As in the US, anything even remotely related to any investment vehicle is highly regulated and providing guidance and advice without the required registrations, licenses and oversight can and will land you in very hot water, very fast.

All that said, I think with the right approach, something like this could be great for personal use as long as it integrated with multiple investment companies and could track and recommend based on all of them.
I always assumed it would. Back when the successors to Windows were named Longhorn and Blackcomb and they were taking a decade to release, I assumed they had gotten smart and we're going to play with Apple on top of BSD or other Unix. There were always rumors that internally, many MS programs compiled on Unix.

In any case, I still think it's a smart move. It doesn't mean IIS or MS SQL Server need to go away or would even lose market share. (But I'm stating that as a "perhaps," not a fact :) )

If not, at least they're pushing many of their core technologies to it (.NET, etc.) so it's still a net positive.
Out of interest, do kids get taught weapons handling and how to shoot at high school in the US?

[NB I'm asking because some kids get taught these things in the UK]
That's a shame. Hammer is an awesome little lib, I think I started using it back in 2013, have only good things to say about it.
In reply to Joe (the reply button appears disabled for me). Yes doctors, as with professionals in other fields are encouraged to keep up to date with the literature.

However they're exquisitely busy people, and no one is paying them to spend the time to keep up to date. Sure, there are programs that encourage it (usually called 'Continuing Medical Education') but they're often very weak, easily ignored and there is a lot of pushback by doctors themselves against them). If you take a look at the volume of information coming out every day, coupled with the fact most of the papers just plain suck, you'll realise how it's pretty much impossible to stay afloat.
Cupla de remorca auto
The #1 Enemy of Data Loading in SQL Server