skysight-inc/HackerNews huggingface dataset:
So grow the embryo further and sequence more of it, or draw upon the prior information about off-target rates to make the best use of 30% coverage and pick ones with inferred rates which are acceptably low. Or use even more CRISPR to get rid of existing mutations to maintain total mutation load at normal rates... Many options.

(Really, all these comments sound like people trying to find an excuse for why it doesn't work, rather than consider how it could work.)
I started using computers at age ~2, programming at ~7 and learning CS theory at ~10. One guess what my occupation is. :P
Casual insults and flag burning in the dev community
If the comments are consistently reflect some political position then the downvotes are not content independent. Moreover irrespective of what the political position is, there are people, including myself, who generally find political partisanship in HN comments detrimental to the community in most cases.

If as you postulate, there is an identifiable faction with a political agenda, then either user, moderator or software intervention would hardly be surprising. There are plenty of places on the internet where promoting a political agenda is considered fair sport. HN, for better or worse, is not among them.

Anyway, if it is Dang, then you can live with it or find someplace else for politically partisan posting.
IoT and DIY = My Sensors
Technological generalist: programmer, project manager, product developer, database guy, etc.

Why am I in tech? Partly due to participating in the Duke of Edinburgh's Award program and partly because I just took whatever was interesting at university until I was forced to pick a major... when I tallied up my course credits, the shortest path to a useful degree was "computer science" so I did that.

Why does my career look like the plot to "Memento"? Because each time I reached a point where my work was no longer that interesting, I looked around and started doing something else.

So I went from front-line cast member at Disney World[1], to a university grad, to Java dev for a small dev shop, to Perl/CGI and Javascript at a tech mega-corp, to acquire/process/present data on a trading floor, to semi-retirement, to Japan, to a web-dev shop, to an ecommerce mega-corp. At the moment I don't do any development but that will likely change soon as I miss it.

I feel I've been really lucky. I could easy have (and almost did) crashed and burned but somehow it has worked out so far.

The trick is to look at every opportunity and ask yourself "if I turn this down and never get another chance, will I look back and wish I had done it?". If so, think hard about what really matters to you and do whatever will maximize that.

[1] I took a year off university to go work at Disney on a cultural exchange program. It was an awesome experience, I met my future wife (who was on a similar program) and gained extremely valuable customer-relationship experience.
The movie hackers. I'm a software developer :)
I was offered an internship/mentorship by a family friend to do web development since he knew I was already fairly well-versed in computers & higher-level programming concepts. The rest is history.
Spotted salamander young come pre-equipped with photosynthetic algae
This would just cause people to create one company per x patents.
it's amazingly easy to dismiss problems you don't fully understand and will never have to fix, but it's not a terribly interesting line of conversation to read. kinda feels like you masturbating all over a public forum.
It was December, I was bored to death staring at my four screens and thinking the weather really sucks in Europe in winter, and some guy calls me out of the blue asking me if I want to move to the beach. I had a chat with a few colleagues, one of them told me he spent a year in Australia and loved every second of it; his wife refused to move from Europe as she liked to be close to her parents, so he was stuck in the miserable weather and resigned to his fate.

I took the Skype interview at 6am in the dark of my flat, wearing my suit for work, and he made sure to tell me about how he had just gone surfing that morning. I had to do three trades from the train platform due to the delay and a time change in South Africa we forgot about.

My boss was busy making a lot of money on a volatile morning and took a couple hours to process my verbal resignation, at which point he jumped ("you WHAT?") and told me to go see HR. They trusted me, and were relatively busy, so they let me stay til the next day.

We had a chat in a conference room where he told me that his biggest regret was how his career kind of "just happened", with positions of ever increasing money and responsibility keeping him in the game until he was life-locked (kids, house, cars, skills, network...). He encouraged me to go seek adventure, he had wished to go to Asia at "my age" but never got round to it.

Sydney was even more awesome than I imagined. The rest kind of followed naturally; that and I never managed to get back in, so had to keep going, self-teach, moved companies, etc.

But it all comes down to a cold, miserable day in Geneva and an executive trawling LinkedIn for suitable hires for his team downunder. I sometimes wonder whether I'd have eventually quit to do my own thing, or whether I'd be, like some of my friends from university, debating whether to go for the DBS or the F-type this season.
Actual math is really a pain in the butt on any computer, in any language. Doing it all in binary efficiently is the problem.
The closest I could find to support your assertion is

Lessons learned from his research in this area led to creation of Stand2Learn, an offshoot company of a faculty-led startup that manufactures a classroom version of the stand-biased desk.

I have been using a motorized adjustable height desk at work for close to 8 months now. I use it in the standing position almost the entire work day, every day. Anecdotally, I do not buy that it makes any difference to my thinking ability. I find it is better for my general physical well-being.
They were big, heavy, and needed batteries too often. Expensive, too. They are retro-chic now, though. A good specimen will cost you north of $1K.
Indeed, I believe all x86 CPUs require some kind of microcode, but RISC processors in general don't typically require them.
There's a sort of catch-22 going on. We all have some variation of this story: When I was younger I wanted to live in SF and I couldn't afford to buy anything anyways; now that I'm older (42), rural life is more appealing and the finances work... but after 13 years of living in the city, I have a broad and firmly established friend group that I am loathe to give up, even taking a dozen of them with me. So we picked an arbitrary cutoff of 2 hours from SF.

Two hours covers a lot of counties, but none with ordinances that permit rural compound housing. I don't know how far you'd have to go. I don't think there are any in CA.
I'm a stay-at-home dad.

I fell in love with my son. He drove my wife crazy. She'd rather be coding.
I am buying one right now. Thanks!
Entrepreneur in the software business.

I've been interested in computers and software from when I was 8 or so. I've to thank my father who introduced me to computers when he let me use his C64 (for gaming at first but I quickly turned to writing Basic programs as well).

I became an entrepreneur because of freedom and flexibility.
thanks for your inputs. Will focus on the list of items you mentioned above.
Common Lisp

(ql:quickload :drakma)
(ql:quickload :cl-json)
(ql:quickload :local-time)

(defparameter *data*
(cl-json:decode-json-from-string
(drakma:http-request
"https://gist.githubusercontent.com/jorin-vogel/7f19ce95a9a842956358/raw/e319340c2f6691f9cc8d8cc57ed532b5093e3619/data.json")))

(with-open-file
(stream (make-pathname
:name (local-time:format-timestring
t
(local-time:now)
:format '((:year 4)(:month 2)(:day 2)))
:type "csv")
:direction :output
:if-exists :supersede)
(loop initially (format stream "Name,Credit Card~%")
for slot in *data*
for name = (cdr(assoc :name slot))
for card = (cdr(assoc :creditcard slot))
when (and name card)
do (format stream "~a,~a~%" name card)))
I do not think they failed to crack social, just look at YouTube.

My only beef with Android is that they change the UI on their core apps. Its like what MS office did going from 2003 interface to the ribbon interface. I prefer a stable consistent UI
Report reveals 1 in every 5 Android Apps is Malware
goe bezig manne!
My cousin studied the same and I'd see him making software (cheats) for this game some members of my family played (me included) and wanted to do the same.
Liquid mercury found under Mexican pyramid could lead to king's tomb
I'd be surprised if it was just to see one's karma points. Reading the actual comments would be more useful.
If it came with Windows 8 (licence or pre-installed) the key is embedded in the hardware. No need to type it in.

Also, Microsoft has a tool to download Windows 8 ISOs - no need to bother with the OEM.
Immigration reform? What's that supposed to mean?

Huh, and here I just thought I took too many downvotes for expressing Marxist views on a site where everyone's supposed to want to be an entrepreneur (ie: petite bourgeois).
Exactly. I would put stackoverflow closer on the spectrum to github: it provides information that relates to how to the candidate performs actual work, not intellectual masturbation.
Hacker News Android app:
https://github.com/hidroh/materialistic

API testing with Cucumber:
https://github.com/hidroh/cucumber-api
I had goals and dreams of becoming a professional chef. Even applied for Le Cordon Bleu my senior year in high school.

In the meantime I was tinkering with building websites and learning HTML and that. I built a few sites and one day a friend who taught me told me to put some playboy style pics on my site and it'll attract people to come. Being 16 I was down for looking at hot girls. So I did. Then later he told me to sign up for these "webmaster programs" and put links on my site and I can make money. So I did.

Long story short, Paris Hilton did what she does best and lets a sex tape of herself leak and I got ranked in the top 5 sites when people started hammering Google searching for it and I was doing about $5-10k/week in revenue off that video. I decided after 10 years of running porn sites I'd bunker down and really learn to program, and now I'm a software engineer.

So you can say Paris Hilton is the reason I do what I do.
Freedom.

The reason I founded a startup is the same reason Jack Sparrow is a pirate. The freedom to choose what to do and how. And when.

For example, right now I'm in the middle of a 3 week paternity leave because of my second son's arrival. Here at HN there's this vibe that if you run a startup, you're not supposed to sleep or take vacation. But really, why be your own boss if you don't use the freedom that comes with the package?
Point-of-Sale malware on the rise, the opinion of the expert
Yeah, sure. I'm in Illinois, so I can discriminate based on political ideology... totally valuable.

EDIT: My point is this can be a bad idea.
What is the rubeosity of creating a word to essentially say "overly complex" and then taking the time to quantify it for different situations?
I started trying to make games when I was 5 or 6 on a ZX Spectrum. In retrospect, I never chose to become a software engineer... it was just the obvious thing to do. Interestingly, at that age I was also starting to write short stories. I didn't explore that path professionally, but I've taken writing seriously as a hobby a couple of years ago. I've written a novel and three screenplays so far.

In summary, I'm doing what I was already doing when I was 6. Not sure what to make of that.
Programming was my second choice.

I wanted to be a math professor. One day I'm sitting in the office of my favorite professor and we're talking about grad school and PhDs. I asked him if it was worth it. He told me that you don't do it because it's worth it, you do it because you love it. I knew this, and I loved math, so I nodded.

Then he told me what my career could look like after I graduated. Part time, working at 2-3 universities, where teaching math was more of a hobby than a job. I decided that for me, no matter how much I loved math, it wasn't worth it.

Fortunately, I'm pretty good with computers and programming comes naturally given my math background. I'm really satisfied with where I am now, but math is the one that got away.
An App Launch Guide for Indie Developers
You will be punished if you criticize communism and angular.js among other subjects where political correctness and idiotical consensus have more weight than reason. The kool kidz rule with an iron fist, and they know no mercy.
Do you still cook?
I'll save this for the inevitable barrage of LinkedIn messages that will appear after I start a new job soon.
Software Engineer since the early 90's, programming since the early 80's. Because I'm not smart enough to be a mathematician.
I'd have gone a different way since my setup and approach was a bit different (I took a more visual approach). While this solution is elegant, it's also incredibly hard to do in the real world as it requires far too much knowledge to properly assign the "correct" definitions. It's no different than having a perfect health heuristic land on your lap.

When I did this a while back, my approach was to construct a 5x4 matrix with blanks (5 unique dates x 4 unique months). This allowed the clues to cross off entire rows and or columns until only 1 pair stood standing. Personally, I find the construction of the solution much more interesting than the problem itself given how many people participated.
Hello, no idea if I'm late, but is the .WEBSITE is still available? In case it is, my e-mail is clnthsmtxs@gmail.com

Thanks
I don't support the existence of software patents at all. That said, I also don't think the benefits of patents should be interpreted so narrowly, or that we should judge patents by the single criterion of their "actual" intent instead of these other benefits.

The other benefit is that it enables companies to do innovation where they would not have been able to keep the idea secret in the first place. E.g. a pharmaceutical drug whose chemical composition would be trivial to reverse engineer. In that case, the patent does not serve the purpose of making the knowledge public in exchange for a monopoly. What it does do, though, is incentivize innovation be rewarding the inventor with the "rights" to that idea.

The real problem with patents is when patents are of trivial things that anyone could have thought of without much effort. That is why I don't support any software patents, because it's so much easier to patent trivial things in the software world than the physical world.
Why not ldd?
I grew up in a software company. Mom worked for a German company that designed embedded software used in automating sea ports and satellite tracking / telemetry. Mission critical kind of stuff. The company would hire developers from all over the world and they would come to Germany and often live with us for a couple of weeks before finding their own place. So many of the engineers became "big brother" kind of friends to me. One of them gave me my first computer. A Sinclair Spectrum 48k. I started using unix (running on a VAX) at work playing with their kit, too.

Mind you I didn't want to become a computer programmer at all. I would come home from school and stop in at my mom's work and all these engineers would be sleeping under their desks because a port worker had been killed when a container ship struck a pier or a satellite entered low-earth orbit and flamed out costing $100 million or something. I associated programming with tragedy and high stakes.

So I went to art school. My senior year I was spending more time in the computer lab than anywhere else. We had a lab populated with Silicon Graphics workstations and I'd written scripts to render my animation across all the machines so I could get a result in minutes instead of hours. Then the web became deregulated.

Lately I found my way into working on rail automation software that had safety critical requirements. Which is exactly what I never wanted to do and so I quit after 3 years.

I'm still in the industry and haven't figured out what I want to be when I grow up.
Forget Cars, Tesla Wants to Revolutionize Power Storage
If we take silence as indicative of lack of knowledge, then nobody needs to speak.

Bernard: Silence (he doesn't know the answer)
Albert: Silence (he doesn't either)
Bernard: I know it!

Interestingly it then becomes relevant who was silent first.

Basically it's nonsense.
Compliance, particularly the section and additional info for Electromagnetic Compatibility Compliance http://www.lenovo.com/lenovo/us/en/compliance.html
decode input from JSON

grep for items with a 'creditcard' field

map each item to a string with its 'name' and 'creditcard' fields

for each string (and "name,creditcard\n"), print it

into 20150425.csv
Consider adding a couple of wheels to your design. That way you don't qualify as a permanent structure. In some places it is enough if you just don't have a foundation.
Conincidence mostly. I didn't actively search for what I'm doing now (10% hardware 90% software from very lowlevel microcontrollers/fpga to highlevel business apps). Or maybe is was just destined to be: I wouldn't really want to be doing something else (well, except for quitting jobs all together and go live far away and be self-sufficient, but that's something with a long learning curve).

Wanted to go for biology first but hearing what it would take to really get into cutting edge research I changed my mind and went for what seemed, given my hobbies and complete lack of interest for other non-tech fields,the most logical: electronics engineering. Thesis project was picked truly by coincidence (basically the last one left because we were late, lol) but the company offered me a job because I fit in pretty well. Still working there now parttime (did work in different departments as well in the meantime, now I'm back where it started) and parttime for a startup but the job is similar.
This is pretty cool! How old is your son now? Do you intend to remain stay-at-home forever, or until your kid(s) reach a certain age?
Facebook Safety Check: Nepal Earthquake
"I must create a system, or be enslaved by another man's; I will not reason and compare: my business is to create." -- William Blake
NASA may have accidentally created a warp bubble
As a general rule, skyscrapers don't increase density much, as most of the space is taken up by elevators, plumbing, electrical, and so forth. A block of five-floor walkups is almost as dense as a 50-story tower-with-empty-space-around-it, and much less expensive to build.

Walkups, not skyscrapers, are the best bang for the buck.
What Rect is not the shortened of Rectangle?
One thing to consider though is the grepability of a codebase. By relying more on nested modules, module aliases, opens, local opens, then many constructors have more than one way to be written and it makes it harder for grep to find what you look for. Of course people should not use grep and instead rely on IDE or tools that understand deeply the programming language being edited ... which makes the problem I mentioned go away. But still it's nice to have the possibility to use simple tools like grep and that they would simply work.
Retiree?
I cannot tell if the photos in the article are low quality, or the 3D prints themselves.
I disagree with most of this. Giving cash is probably good, but do it via established, organized structures like the Red Cross.

Well-meaning individuals in private jets bringing stuff is probably something that is going to make rescue work harder, not helping. To start with the logistics, any private jets would just overburden the local flight control system that will now be under stress, and there are not going to be much free parking places for jets in Kathmandu airport. And remember, it's not a big airport to begin with.

People may be frustrated by authorities in third-world countries who may be somewhat inept, but still, uncoordinated attempts to help are probably counter-productive.

And grudging about multi-millionaires who used the indigenous people of that country in order climb the highest mountain is also not useful. They were probably helping the country in the best way anyone can, even if they were seeking personal thrills: servicing climber tourists is one of the main export industries of countries like Nepal. The customers are mostly decent people even if they are rich, and they are (mostly) not doing anything bad, they are employing people and giving them a contact to the rest of the world.

(Not any personal expert on Nepal, but have a couple of friends who have stayed in the country in various development aid roles for a year or two.)
Wow, I got that extremely wrong huh. Thanks for the correction.
Career: Finance/Trading Platforms Developer (by accident). I wanted to be a doctor. And I hate math.

When I was 7, me and two of my friends signed up for a local free summer course for computer skills and typing for Pioneers (this was in Kiev, Ukraine, in mid-90s).

Learning MS-DOS was pretty cool and different. It was also great fun to make infinite-loop batch files that printed out some vulgarities on screen when the instructor wasnt looking.
One day, when walking into a class, an older (maybe 15?) guy in corner of the room (who turned out to be a sys-admin) drew my attention: he had a bunch of weird text on screen in some program I've never seen before (all i knew was "copy con mytext.txt"). Then, at a press of a button, his computer lit up and started drawing colorful circles and making noises.

I've just experienced QBasic (http://en.wikipedia.org/wiki/QBasic).

I was fascinated by what I saw and, with encouragement of the the sysadmin visited couple of sessions of an "advanced programming" class. Although I didn't understand much, I was hooked.
With great support from my parents - who - and i'm still not sure how - found the means to get me a PC at home (those cost many months of salary at the time) - i started tinkering with graphics, windows, and random computer stuff.
Then a "Delphi for Dummies" found it's way to my hands somehow.

The rest of it all, leading up to today, is history as they say. For me however, it's a series of completely random, lucky, events that gave me the initial interest and subsequently permitted me to pursue an absolutely fascinating career.

Today, i am actively dedicating time to get young engineers interested in technology and show them what amazing possibilities it brings.

Maybe one day i'll even write a blog about it :)
Loved computers since childhood, hence I'm a programmer!
Sublime Text and vim mode: http://youtu.be/7OOHUbpiX1A
Denmark is fastest fixer of critical security bug
Perl is water in the cupped hands of our minds. I have yet to meet someone who can keep it from slipping between their fingers without consistent effort.
It seems the quake caused some big earthquakes on Everest, reports are a little unclear now but it seems damage was done.

https://twitter.com/danielmazur
They are so low res. I've seen way better prints:

http://i.imgur.com/jfoAHQL.png

http://i.imgur.com/ZhSen1v.jpg

http://i.imgur.com/SUXUNwL.jpg
The middle button was good for scrolling. Although I see your point, I really can't stand non-thinkpad and non-Macbook touchpad arrangements anymore.
Pure luck.

After a few crazy moves and dropping out of 3 different universities, I was down to washing dishes at some crap restaurant and underpaid tech support. After 18 months of that, I told myself I deserved better and just quit. A week later I got called for an interview at some financial-software company I'd never heard of, they were desperate for an Italian-speaking geek. 11 years later, I'm a well-paid consultant in an expensive niche.

I'm not an ambitious guy, I've always just wanted a nice house, not having to worry too much about money, and time to geek around. If I could do it all again, maybe I'd study harder, maybe I'd emigrate sooner, I don't know.