skysight-inc/HackerNews huggingface dataset:
If you've been looking to place bets on early stage companies that can boom or bust - often for little to no reason other than trending with the sector, biotech in the public markets has been the place to be the last few years. It very much is resembling the .com boom in internet related technology.

RNAi has had some great moments the last few years in particular, and some spectacular busts and more great moments, for instance. But the public biotech sector as a whole has essentially been 1 big casino in the public markets. Even the ETF's are up a few hundred percent the last couple years.

I believe there's one more huge parabolic move before it tumbles - we'll see. Anyways, my point is we like to focus on the VC bubble in technology but the real "frenzy" has been in biotech IPO's and early/mid stage clinical companies even though private equity technology gets all the bubble press.
I don't care about the Bitcoin argument either way, but I'm annoyed by how you keep bringing up its use of electricity. There are over 877,500 bank branches in the world, each consuming a nontrivial amount of electricity every day.
There's a paragraph in the Phase I Audit Report (published a year ago) which includes a checksum:

> The iSEC team reviewed the TrueCrypt 7.1a source code, which is publicly available as a zip archive (“truecrypt 7.1a source.zip”) at http://www.truecrypt.org/downloads2. The SHA1 hash of the reviewed zip archive is 4baa4660bf9369d6eeaeb63426768b74f77afdf2.

The Phase II report (today;s release) claims to be auditing 7.1a, so I assume it's exactly the same version and ZIP file.

Last June, they published "a verified TrueCrypt v. 7.1 source and binary mirror", including file hashes, on GitHub: https://github.com/AuditProject/truecrypt-verified-mirror

I just cloned that repo and inspected the source ZIP; the SHA1 sum matches what they quote in the report.
> hovels

hovel: a small, poorly built and often dirty house

So, small houses must, by necessity be poorly built and often dirty?

I believe this is kinda where the problem lies in our culture. Only a large house can be nice, middle class, and a symbol of success in our culture.
Ask HN: The possibility of an Autonomous self sustained business
There was a comment a while back on Hacker News about the fact that with the advent of cryptocurrencies and such, a program could become its own artificially intelligent company, capable of self sustaining and growing without human interaction, though I am not sure why cryptocurrencies would suddenly make this better or easily. Now a bit ago I noticed that on the Long Bets there is actually a bet that in 100 years a sentient artificial intelligence will also be a corporation. [1]

This seems to assume a level of sentience that we do not have nor can we really see possible in the near future. But would sentience be a requisite in order to accomplish this goal? It seems a system would just need:

* A way for the system to handle real world financial transactions
* A way for the system to support itself financially
* A way for the system to understand its own needs for resources and expansion
* A way for the system to evolve to meet changing demands

If we remove the need to create hard, sentient AI and just focus on a self directed system which finds ways to survive, evolve, and thrive based on resource constant, wouldn't this sort of system be possible today? And wouldn't a capitalistic business model, where value is given to a consumer in exchange for necessary survival resources, be a sustainable evolutionary model?

Also, I wonder how far a system like this would be able to evolve itself. We seem to want AI to get more intelligent by evolving itself. But even if this “Business AI” had to hire human engineers to evolve it, wouldn't this be the AI self directing its own evolution? It seems like this could be more than just a thought experiment. It could be built now.

[1] http://longbets.org/360/
Yep; if you tie yourself down with children, what do you expect to happen besides getting yourself stuck?
You can audit Windows. Microsoft will give you the source code.

http://www.microsoft.com/en-us/sharedsource/default.aspx
Bitcoin transaction fees are lower currently because they inflate the money supply to reward transaction processors. This puts downward pressure on the price. Once the inflation is cut off, its not clear what will happen with the fees. If the hashing power stays constants or decreases while the user-base increases, then low fees might still be feasible, but its unlikely to pan out this way.

Speaking from a technical perspective only, there is no way that Bitcoin can process transactions at a lower cost then a centralized method. A distributed log backed by proof of work is necessarily more expensive than a trusted, central server. Most claims of cost reduction come from the elimination of features, such as chargebacks, which will then be implemented by third party, resulting in unbalanced comparisons.

Supporters also point to smart contracts as cost-reducer, but the surface area where smart contracts can be made to work without human intervention is low, and I doubt many of these hypothetical cost reductions will be realized.
Turn your startup idea into action in 30 days
There currently are 2 issues the web has to overcome:

1) Via a manifest file, websites can be available offline. But currently, if people want a tool they "download an app". They don't add a website to their homescreen.

2) People can easily pay for an app. But not for a website.
Hoax-detecting software spots fake papers
The United States hacks and counterattacks China all of the time.

The reason for calling the DPRK's attack on the propaganda creation of the State Department 'cyberterrorism' and 'cyberwar' is that it aligns with US foreign policy (SK's official policy now is to pursue reunification).

NK is going down - China is more complicated. We do hack and counterattack China though, all the time.
I assume the data center is in France. Is that correct?
One Codex (YC S14) is hiring engineers to work on infectious disease diagnostics
One Codex (YC S14) – Genomic search and data platform. San Francisco, CA (https://www.onecodex.com).

We’re a software and biology start-up building a platform for microbial genomics – an essential piece of infrastructure for a world in which we increasingly understand health, disease, and our environment by transforming biology into data.

Our first application area is infectious disease diagnostics – where we’re already working with doctors, epidemiologists, and others at the world’s leading public health and research organizations. We were also awarded a $200,000 prize by the CDC for our work on “strain-typing” pathogenic bacteria, and are backed by some of the best investors in Silicon Valley.

We’re looking for talented software engineers to help us build towards our vision for a global genomics data network and enable widespread in silico diagnostics.

YOU’RE A GOOD FIT IF:

- You’re a generalist software engineer that loves hard problems

- You want to work on a technology product making an important real-world impact

- You’re excited about joining a small team and directly impacting the shape of its technology choices, product, and business

- You communicate well and work effectively with others

- Pluses (but not requirements): biology/compbio background; experience with Docker in production; prior experience with Flask, React, D3

WHY ONE CODEX?

- Important problem: We’re not only working to build a better diagnostic test for infectious diseases, but setting the groundwork for entirely entirely new clinical, scientific, and public health applications that will come with an improved, real-time understanding of “microbial space”.

- Hard, intellectually interesting challenges: Amongst other things, we are 1) applying and developing cutting-edge bioinformatics algorithms; 2) developing and deploying new data structures (really!); 3) finding better ways to manage messy genomic data; and 4) and running Docker in production. In short, there are plenty of near- and medium-term hard engineering challenges, and there’s more to our technology solution than just a simple CRUD app.

- Upside: We offer a competitive salary, meaningful above-market equity, and the chance to be an early employee in a well-positioned startup.

OTHER BENEFITS

- Full medical, dental, and vision coverage

- Flexible vacation policy and relocation assistance if moving to the Bay Area

- Whatever computing set up you prefer

APPLY

Please send us a note about your interest and background at careers@onecodex.com or reach out to me directly at nick@onecodex.com.
Some yes.

Kidney failure in a small set of patients. Typically urine/blood samples are taken for the first few months to check for this. There's some evidence of bone degradation in long term use (think 10+ years) but its mitigated with regular strength exercises. Beyond that not much else the formula has been altered a few times to make it pretty safe to take regularly.

Some people experience gastrointestinal distress from it but that usually passes after a month. If it doesn't they usually just stop taking it.

All of the side effects stop if you stop taking it.
@mxstbr Thank you very much for posting this here!
I feel this needs to be said about most frameworks these days...by the time anyone agrees on anything, a new framework will come along and everyone will start praising it as the new holy grail.

I'm so glad I did not follow though with an Angular project about 2 years ago. It would have failed miserably and been difficult if not impossible to manage at this point.
Yes, absolutely. In the pipeline! :)
Re: 3 letter friends CAs, I believe it. Sort of have to do that, given their operating goal of being able to read everything at will. Its low-hanging fruit, and the only real reason to continue with such a centralized authority-based scheme is to support that type of thing.
Hi all! I'm the person who did this teardown. If anyone would like to fire some questions or critiques my way, I will be watching this thread like a hawk.
How tough can game making be? One AAA dev offers a playable answer
Wonpro AST-7 Universal Adapter for Travel Recalled Due to Risk of Electric Shock
Cool. I've always wanted to make an emulator and this article makes it seem less intimidating than it would.
Do you have any thoughts on the scenario I described?
The internet != hypertext/www.

Title of this should have been: "Is the app-only economy going to kill the web?".
So Your Company Has Been Found Using Alex’s Photographs Without Permission
Those bank branches burn electricity to keep lights on so that people can work, and to run computers that keep track of the same information you'd need to track in a hypothetical all-Bitcoin economy. Bitcoin burns electricity to solve a math problem of escalating difficulty and cost whose solution has no intrinsic value.

That's overthinking it, though; really, the dig about electricity simply comes from the fact that Bitcoin is essentially a competition between "miners" burning escalating amounts of cycles.
Its the same battery tech. The only difference is that daily driving, which is the typical use case, wears them out faster. Probably due to getting the batteries hotter as they run longer, in traffic, etc.

Its still lithium-ion. It will behave the same way regardless of brand or celebrity CEO worship.

>I just told you the actual numbers

From a non-daily driver two seat sports car. Other sources follow the LEAF's numbers. My buddy's Porsche runs fairly well and its 30 years old. That doesn't mean you can have a 30 year old daily driver.
A 6502 in ~2500 lines of C? Really? Bookmarked :)
Ok now it seems more legit... Yeah, the content interests me but you know, there's so many shady websites out there that you have to keep your eyes open... There's a typo USING Z TO JUMP TO "FRECENT" FOLDERS
Has anyone benchmarked the infinite storage?

Unlimited transfer seems too good to be true.
Naughty Dog switched to PLT Scheme during the Uncharted series, which is documented here:

http://www.slideshare.net/naughty_dog/statebased-scripting-i...
As someone who has the word "architect" in his software job title I feel like pretty much everything I read on the topic only serves to confirm that nobody knows exactly what software architecture is. I felt that way after reading "The Architecture of Open Source Software," which was essentially comprised of a set of discussions of how various popular applications were put together at varying levels of abstraction and without unifying themes of any kind. I feel that way after browsing this PDF of architectural "patterns" too. When "layered" and "event driven" are presented as sibling patterns at a common level of abstraction I don't think there is any underlying principle at work that makes sense. Or at the very least, if there is someone will have to point it out to me.
I think your critique of notifications is good, but there is a bit more to the Apple Watch.

(As far as notifications go, iOS already allows you to respond to a phone call with a selection of canned text messages. I find them useful when I can't talk and I could see this type of reply being useful for a non-trivial subset of notifications.)

As I see it, there are three main features of the Apple Watch:

1. Notification & quick reply device
2. Fitness tracking
3. Payment device (ApplePay)

Are those three features (and/or the myriad of smaller features) enough? We'll have to wait for people to actually use it to find out :-)
Solar Eclipses from Past to Future, Earth to Jupiter
Ey, you have your videos on youtube... wouldn't it be easier to just have a channel and let people subscribe to the channel?
I'd love to try this, but it looks as though they will only be offering an iOS app?

Edit: Ah, an Android version is to follow. https://www.kickstarter.com/projects/1320191398/karen-an-app...
When Green Dot acqui-hired Loopt, Mike Moritz was on both boards.
If anyone wants to get into GNU Make deeply, one would think that the obvious thing to do would be to read the official manual for GNU Make.

Anyone who writes their own, not freely available, manual to a free software program, is dividing the world into two halves: Those readers who can afford this new book, and will pay the author (not the writers of the software, mind you) for a nice manual, and those readers who can’t afford to pay for this new manual, and will have to do with the inferior¹ official manual. Those readers who can afford the new manual will not be incentivised to improve the official manual, since they have the new, better, one. Therefore, this act (of creating new manuals which are not freely available) is reducing the number of readers who can be expected to help improve the official manual to those readers who cannot afford the new manual. These effects, i.e. reduced funding and reduced help to the original software authors, is not, to me, worth it to have a new, even if better, manual.

① Presumably, by their own standards, since they wrote a replacement manual.
Yukihiro Matsumoto
Creator of Ruby
"I am having fun learning Ruby at http://rubymonk.com. I like this type of lessons ;-)"

Huh? This is the guy who wrote the language. Weirdest endorsement ever...
Awesome! Have an idea for a field trip app, and it could benefit from an API for this! :D
This seems silly, but Microsoft appears, on the surface, to have purchased Skype with the intention of selling surveillance to the NSA. They immediately replaced the whole network architecture and encryption setup with something that had weaker security and was subject to compromise of Microsoft.

That's the sort of player we're dealing with, and that's why Bitlocker is not just improvably secure, it is best to simply assume that there are deliberate backdoors, whether any particular employee knows of them or not.
You forgot to quote this part:

> The reason people use explicit patent grants is to avoid getting into some unsettled law. Particularly, the sublicensability of implied patent licenses is not clear. The TL;DR of this is "the answer is clear if you get the software directly from person owning the patents. If you get it through someone else, like say, a linux distribution, it's not clear what happens". The related doctrine of "patent exhaustion" that plays into this is also not settled, and currently the subject of a Supreme Court cert petition by Cisco.
So teens are a vangaurd that is needed to attract 20's and 30's who will actually spend money?

I don't think that adds up. 20's and 30's will use things like Tinder, Craiglist, eBay, etc that meet their needs and... generate useful outputs for both parties.
I'm pretty sure everything you're suggesting here is a workaround that breaks the intended features of Make.

If a multiple-output step fails, I want the outputs to be deleted, and the rest of the dependencies to keep working so I don't have to rebuild everything from scratch. Whatever you're suggesting with dummy targets sounds like it's certainly not going to track the dependencies correctly.

I already know that directories aren't tracked correctly as dependencies.
Bitcoin is an especially bad store of value. It is subject to stark and unpredictable devaluation, followed by manic upswings that increase its volatility and harm its utility to normal business, which selects out the boring currency users that would be the backbone of a sane valuation and selects in toxic speculators that amplify its volatility in the next iteration of the cycle.
Potentially: realizing personal fulfillment based on nurturing your own offspring, and learning new depths to connecting and loving others!

But if you're young and unattached, so much more the reason to travel and fly and explore. For most people, it's a lot easier to do that before kiddos.
4K vs. UHD: What’s the difference?
Mr. O'Church has neglected, or failed, to include ideas in praise of nepotism. In other words, expect that Google net benefits from access to Tom's network or experienced a favor from the VC previously.

There's even an idea for this in accounting: goodwill.

http://en.wikipedia.org/wiki/Goodwill_%28accounting%29
Tried Ruby koans?
No, for the reasons laid out in the article. Not least: websites (at least well designed ones) are platform agnostic.
To me, this is like asking is replacing the hand-cranks with electric starters going to kill the car engine.
you can get an AMD A1100 dev kit, but it's like three grand.

I mean, obviously, that isn't a realistic price, but if you want an ARM server with ECC ram right now, that's one way to go. (my understanding is that once AMD ramps up production, which is looking less likely at this point, it will be on the order of a few hundred bucks.)

Most people actually doing things with ARM servers are using non-ecc ram, which I don't think is particularly practical for real world use. The problem with non-ecc is not that it fails more often; the problem with non-ecc is that you often don't know when it failed.
You are right that the advantages the Atari ST and Amiga had were absorbed into mainstream consoles and computers, but I think the time gap is a little longer than a few years. The Amiga released in 1985, but the Sega Genesis/Masterdrive didn't come to the US until 1989, and didn't arrive in the UK until 1990. Windows 3.1 was 1992, first color Mac was 1993, and Sony PSX was 1994.
My next project is to take a look at it and perhaps make a trial system using it. Please tell me about your pain points.
Every news source is biased. Your job is to understand what that bias is and compensate. By following multiple news sources with different bias you can discern somewhat the truth of matters is as it lies somewhere in the center. Some outlets are more predictably and openly biased towards one direction.
In spite of their niche popularity [...] the FDA challenged the acceptability of TheyFit condoms [...] having noticed [...] that some of the sizes did not meet ASTM dimensional requirements. The smaller sizes, in particular, didn’t hold the requisite volume of air and water in the air-burst test and the water-leak test, because they were, well, smaller. Glickman [...] was given 30 days to remove his condom from the market, and, after consulting with an attorney, complied.

Wow. So they were forced to take these off the market because they didn't conform to a completely irrelevant FDA standard....
I think that feature only allows one input. It's 1:N, not M:N.
The issue is you need to have a pre-installed Firefox on the device. Too bad, such dependency can't be set in the manifests so it won't pull automatically from App Store or Google Play.
This thread practically demands a NSFW link for classic 4-panel comic strip. If you are at work, think at least twice before clicking the following link:

[NSFW] http://thinhline.tumblr.com/post/5370750268/thl-7-nothing-i-...

The article touches the issue of sensitivity and the need to develop a condom that makes sex more enjoyable. So does the comic at the link above, if in a slightly different way.

In case of markets and products, one can rely on cynicism and economics. In case of sex, we should be able to rely on hedonism.

(Are there any other SL fans?)
Sweet, could you please ping hello@classmill.com? Will keep you in the loop once the API is out.
Amazingly enough in most places with sharply progressive tax codes the people who actually have to pay the taxes are a lot less thrilled with the status quo than everyone else. Though they are certainly willing to pay lip service to its benefits.
My comment wasn't about billion dollar IPOs. I'm talking about small communities that would like to purchase something like a solar panel. Maybe they want to sell excess power and return the profits as dividends. My point is, small scale joint ventures require prohibitively expensive overhead (even without the threat of corrupt government officials). Bitcoin stands a real chance at tackling some of those problems.
once AMD ramps up production, which is looking less likely at this point

Why is that? What changed?
Letter from King Jan III Sobieski to his wife describing the battle: http://literat.ug.edu.pl/listys/095.htm

Describing the captured booty, the first thing he mentions is camels :)

It is surprising that they brought them, considering that they had besieged Vienna 150 years prior and found that camels were ill-suited to the terrain.
Techniques and Systems for Training Large Neural Networks Quickly [pdf]
Strongbox – A method for you to share tips, information, and files
Gigabyte has announced (but not released, as far as I can tell), this:

http://b2b.gigabyte.com/products/product-page.aspx?pid=5423#...
>Buy low, sell high. For now, at least.

Being as how a transaction requires two parties, this is not possible for everyone.
Internet of Health Startup
I am not sure about best, but special needs can require special items, without any notion of superiority or inferiority in the general case.
What is your last point exactly? How a new version of Angular would have made your project fail so miserably?

Change is great, it makes awesome things happen. New frameworks are here to give you a choice, you don't have to use all of them. Angular2 will come with a lot of new features and Google said that they will keep working on Angular1 until most of the users switched, what's bad about that?
YAPF – A formatter for Python files
In Battletoads, Rare went a step further and kept only a single frame for each player loaded in CHR RAM, copying over it for each frame of animation.

As for mappers, the 6502 (along with most other 8-bit CPUs from that era) has 16 address lines, imposing a hard-limit of 64 kilobytes of CPU-side address space. Without bank switching hardware somewhere, there was just no other practical way to access any more program ROM than that. Now, Nintendo could have pulled a PC-Engine/TurboGrafx-16 and embedded a bank switching unit somewhere in the console itself, but hindsight is 20/20.
Compilations of Pranks from TechCrunch, CNN and TheVerge

http://techcrunch.com/gallery/april-fools-2015-the-mega-roun...

http://www.cnn.com/2015/04/01/world/april-fools-day-pranks/

http://www.theverge.com/2015/4/1/8327379/april-fools-roundup