skysight-inc/HackerNews huggingface dataset:
My grandparents have a stylus for their iPad and that helps a whole lot!
I'm not sure I'd lay all the blame of slower/less drug discovery on the scientists or the science.

The FDA has continuously increased the standards required to get a drug approved. Take a look at Librium (chlordiazepoxide) for example. It was the first benzodiazepine discovered. The molecule was first synthesized in 1956. The anxiolytic effect was discovered in 1957. FDA approval came only 3 years later in 1960 [1].

There is no way that would happen today. The truth is, as data requirements increase, so do costs. Increasing costs make development of certain drugs unviable from a commercial perspective. If you're trying to come up with a better cholesterol drug now, you're expected to do two multi-year (2-4 yr), 1000+ patient clinical studies. That alone could run you $500M. Even though is plenty of room for improvement in treating hypercholesterolemia, companies are shying away from pursuing it due to the unattractive economics.

And as for the limitations of small molecules, I agree that current drugs cover a lot of space right now ("we've picked all the low hanging fruit"). However, what drive new drug is new science that determine disease mechanisms. Many of the latest immunotherapy cancer drugs that are coming out (and resulting in very impressive outcomes) are small molecules.

[1]http://en.wikipedia.org/wiki/Chlordiazepoxide#History
> My only other complaint is that it refuses to install FreeBSD.

Did you try installing SeaBIOS on it?
The New Chromebook Pixel
Definitely not, it's just an estimation of what you would need to have a 4G coverage everywhere.

Areas with a very low population density are not completely uninhabited, there's at least a few persons. But yeah in a big national park or in the middle of a big lake you probably don't need 4G as much
It would be much appreciated if someone could explain, succinctly, how differential privacy works and its strengths and weaknesses. Thanks!
Hello, I'm one of the founders of Umedoc. Just wanted to say thanks for taking a look - it's only our MVP - we literally launched just now so we'd appreciate all feedback on things that are broken and things we could do better!
>Lots of people are brainwashed in college to think that all data must be consistent all the time, and that's just not necessary.

I knew it! So a foolish consistency is the hobgoblin of little minds.
Inside Omni
I agree with you—she wasn’t an outsider trying to join the group. She’s a real nerd, culturally. But this is exactly what I (and many nerds) don't care about. I don't care whether Adria Richards is in the in-group or the out-group. I care about her ideas. I care about her code. So far I’ve only seen her ideas, and her ideas include feeling like her life was threatened because of a “dongle” joke. That’s not a scathing review of her as a person—I’m not reviewing her as a person. I’m reviewing her idea. Her idea is just wrong. Everyone has a few wrong ideas—it’s not a big deal.

At the core of the issue of women in tech is a belief that women’s ideas are as good as men’s ideas—on average, women produce as high a percentage of good ideas (and bad ideas) as men. So we want to include women because of their ideas, because we care about their ideas and not who they are.

I don’t know the solution to this problem.

But the solution being proposed in the Adria Richards debate is that Adria Richards was threatened because of who she was. But she wasn’t threatened, she just felt threatened. People are saying we should listen to these feelings and include people like Adria Richards who feel threatened when they aren’t being threatened. It’s an attempt to place her within the group based on who she is, in direct opposition to the fact that her idea, in this case, is wrong. THE ENTIRE POINT of including women is THEIR IDEAS. Holding up someone whose idea was wrong as the poster child for gender equality in tech is diametrically in opposition to why anyone in tech wants to include women in tech.

Not only is this not a solution to the first problem, it directly breaks the ideology that makes tech culture something worth joining.

If we’re going to treat women’s ideas as equal to men’s, that includes treating women’s bad ideas as equal to men’s bad ideas.

I think if you talk to any of the women I’ve worked with, they would describe me as an ally. I’ve called out coworkers on saying sexist things, in front of other people. But I want to solve the problem of there not being many women in tech, not create spaces where people can’t validate ideas because of who said them. If we do that, we’ll just be creating terrible tech companies where women work but ideas can’t be validated, and all the real technologists will move to real tech companies that have no women. A false solution is no solution.
Recent studies showed that links sent via skype are visited from a MS-owned IP address, so that doesn't sound true.
there's no way the median HH income in san mateo county is 88k
> "Never mind the whole lockdown unless you flip that "developer" switch."

Speaking of which, it would be nice if that were a physical switch on Pixels. With the original Pixel at least, there is an issue that if your battery runs completely dead, the bit that tells the computer it should be in developer mode is unset. When that happens, if you have linux installed on it, you are hosed. Everything on the drive becomes inaccessible, and the only thing you can do is reflash ChromeOS.

If I am wrong about that, somebody please tell me. It is making me paranoid as hell about leaving it unplugged.
3:2 high res screen, i7 CPU, 16GB RAM, 64 GB storage...

I will seriously consider this as my next Linux laptop.
Does she use a browser to access them, or the Newsstand?

The Newsstand applications for both of those publications seem remarkably un-terrible, compared to their mobile websites. I agree that many news websites, even the mainstream ones, seem full of booby traps, and that it is a problem in general — just that there does seem to be a solution for this specific case.
Good content, but seriously who signed off on actually presenting this content the way it is presented? Seems like a high school multimedia class project.
You need to get your clicks somehow.
Get Voxel Farm
This is true, but I'm not sure it's relevant in this case. AFAIK old people generally have more trouble controlling how far they push things, but the only distinction we're interested in here is whether they're pushing or merely resting their hand.

This still wouldn't be enough for people with diseases that cause major tremors, but I'd imagine it's enough for people who have lost fine motor control, because we're only trying to distinguish pushing from not-pushing.
I guess you aren't terribly familiar with slide shows.
In the event of an unexpected landing, every Loon balloon is equipped with a parachute to slow its descent

http://www.google.com/loon/faq/
> The whole ChromeOS project seems to have gotten underway because someone at Google observed how much of the computing time was spent inside the web browser.

Well, I think there is something in that direction, but quite a lot in the direction of "the whole Chrome project at Google -- including ChromeOS -- was started because someone at Google realized that Google would have more reach if people spent more time in the browser and had less reason to use non-web software, so they set out to address the issues that make out-of-browser software necessary for what users want to do with computers."
> All Skype-to-Skype voice, video, file transfers and instant messages are encrypted.

> For instant messages, we use TLS (transport-level security) to encrypt your messages between your Skype client and the chat service in our cloud [...]

As expected, it's just network-level encryption, not end-to-end encryption.
I'm the same age, and I have this problem too. Beautifully illustrated by the Guardian's website (sorry for Vine, it was the easiest\quickest way to share this with a friend when i made it): https://vine.co/v/hKOBYhVB2mH
Growing ConvertKit to $5,020 in Monthly Recurring Revenue
I wonder what the underlying hardware is?
More about Java Flight Recorder – You must use this product
That's a good point. The ability to talk with someone at a company who's empowered to make such decisions might be what makes the difference here.
> She kept accidentally clicking on the ads

You know this is the primary business model when Slashdot moves to putting four huge ads right below the summary and fills the screen right to the absolute edges. I don't know how many times I've clicked on the Cardashian game by accident. Is there even one person who reads Slashdot and would play any of those advertised games? Slashdot must expect tons of accidental clicks, though I don't see why the game publishers would want to pay for them?!
We do take what we dish all the time, what we pretty much never dish is public and directed attacks on individuals (or other social attacks of which there are many, such as spreading rumors). If I'm in a room with someone that is continually spouting off about all men being sexist pigs and making period jokes I really don't care, that is their prerogative and I have no right to stop them much less publicly attack them (nor do I feel the need, but that is another issue altogether).
most of the bigger news outlets have very nice mobile apps.
you can buy subscriptions on there and read the news without ads.

since this is obviously not really working (yet?),
i am really curious on how future journalists will generate revenue other than ads (eventually something will come up i guess).
Newsstand. Both have ads in-line -- and she didn't always remember to click "Reader View" in Safari for the Times.

Also interesting: moisture in hands helps with scrolling. As you age, moisture decreases.
No, there is no access to PCI address spaces over the USB 3 port. At least not yet, with existing hardware. As mentioned elsewhere in the thread it's not an impossibility to see an evolved (but compatible) standard in future USB 3 hardware.
I agree 100%. But I also remember posts on different forums about how button shapes are a skeuomorphic anachronism that nobody needs anymore. So if Apple didn't address that audience, they'd still be screaming about Apple's backwards design.
I library for making any look/feel shrinking header in your iOS app
An Entrepreneurial Journey From a Family Print Business to Apps Delivering News
The paper relies on five studies. One with data from 1996, another from 2001, two conducted contemporaneously with the paper, and one longitudinal study using early-1990's UK data.

Also, female labor force participation rate is pretty much the same as it was in 1990.
Ouch, looks like SQL Server 2014 is gunning for Neo4J and mongodb for being a quarter-baked database.
Because if you want to ignore punctuation and case in normal situations, you leave them out of the search index. And then you can't query the same search index for punctuation and/or case-sensitive queries.

So they'd have to create a second index for probably less than 0.01% of their queries, and that second index would be larger and harder to compress.

As much as I'd love to see a strict search, from a business perspective I don't think it makes sense to a provide one.
Beginners guide to interaction design
I have personally verified it's true.
I am skeptical that anything the w3c puts out is "a solution" to anything other than increasingly complex design-by-committee recommendations that no one ever fully implements. How about just good graphic design?
I get what you're saying, but I feel like the example you're providing is off. When people buy a laptop, the major selling point isn't that it runs Windows, it's typically the hardware in it. It just happens to come with Windows because that's what most people use. A major selling point of the Chromebook is that it runs Chrome OS, so in this case yeah installing Linux on it kind of defeats the purpose of buying a Chromebook.
I use Crouton [1] on my cheapo chromebook and it works pretty OK for lots of tasks. I mainly just watch youtube on that thing, so this solution works since I only occasionally want to hop on Linux to get some stuff done.

[1] https://github.com/dnschneid/crouton
@stcredzero I'm interested in building simulation systems for distributed systems, and trying to "gamify" them to teach people about these concepts in a tactile-playable way. Would you be interested in such work? It is less building a "entertainment" game and more an "educational" fun game. Shoot me an email: mark@gunDB.io
Extreme Learning Machine (ELM) for Swift and Objective-C
This was true until the recent update - now there are massive great images and you have to scroll around an infinite canvas-style arrangement before you can even find the article you're looking for. Fails the grandma test immediately.
There really should be some latency in mobile browser between when a clickable component appears and when it is actually clickable. I don't know how many times I've tried to click something and an ad has appeared under my finger milliseconds before I click, pushing the content down. It's infuriating, especially on a slow connection.
I might be misreading this, but I read patio11's comment as "Even if you have CS fundamentals, you are still woefully unqualified to be working on production software. The ability to MAINTAIN and ENGINEER an efficient, secure system HAS TO BE learned on the job over several years of work."

This squares with my experience as well. I have a CS degree from a good school, but switched into it in my last semester after self-teaching myself much of the content while avoiding my physics homework. My first job out of college had many coworkers who had graduated from MIT; none of us knew what we were doing, as far as creating robust maintainable systems, and we needed senior engineers who had actually built stuff (regardless of where they went to school) for that. I've since worked at Google, founded a couple startups, written about a dozen programs from scratch (some of which got used by millions of people)...and found that while I use my CS fundamentals occasionally, the bulk of the know-how on how to engineer a maintainable system comes from actually doing it, over and over again, and dealing with the consequences of my missteps.
"You should be extremely clear up front that you expect your executives to be world-class in their functions. If they are not, they will not keep their jobs. Furthermore, you will not be able to make them world-class, because you are not world-class in their areas."

I see two big problems with this statement:

1. It falls into the "everyone must be extraordinarily excellent" trap. The average employee is... average. Odds are your hiring practices are average too. It is better to focus on getting people's best than it is to focus on having the best people, because very few companies actually do have the best people. If you think your company is different, you had better have a compelling reason.

2. Even for good employees, it takes time for them to adapt to your company and perform at their best. Obviously you need to let some people go, but if you hold a noose over their heads from day one they're just going to worry about looking good for long enough to collect their options/bonuses/etc.. Looking good in the short-term and doing good in the long-term are often incompatible goals.
If the specs* they list are correct, it charges fully in 1.5 hours, which, at 60W, is 90Wh of storage. 90Wh over 12 hours is 7.5W of power usage. That's a nice small number. It's 50% more than the new MB, but significantly more computer as well.

*: They claim to charge enough for 2 hours in 15 minutes. The charger is a 60W charger.
The Access Control Gap in IaaS
I was almost going to bail on the site because I couldnt scroll through it, NOR use my arrow-keys, ugh, horrible UX.
This is one of my pet peeves -- designers hate styling links so they're underlined, but the underline provides a valuable UI cue to the user that the text is clickable/tappable/whatever. So stripping it out makes a site actively less usable.

(You can try to invent your own UI cue to take the place of the underline, of course, but then the user has to learn a new cue for each separate site, whereas the underline is still common enough for people to have already learned it somewhere else.)
How can people of moderate (Silicon Valley) means help?
Actually, engineering students statistically score highest on the LSAT out of any undergraduate degree
Untrue: http://edex.adobe.com/projectphotoshopstreaming
"In the end, a CEO has got to know her limitations."

I love how he switches between gendered pronouns in this article, and ends with a female one.
Is Turkey trying to ban Minecraft for being too violent?
Try to brush it away, but laptops didn't look like this before Apple made them look like this. This may have minor differences from from Apple's design, but let's be honest about the fact that the design is based on Apple's and not anyone else's.
Is cramming on brain teasers in any way different?
This is fine in theory, but most solutions require time, resources, people, money... all things that employees lower down the hierarchy are unlikely to have.

If you're saying 'Bring a suggested solution but don't try to implement it without buy-in', that's a slightly different process.

The issue of who notices/fixes/prioritises/analyses tactical and strategic problems, and who assigns resources for the fixes, can make or break companies.

It's not a simple problem. I suspect a lot of popular solutions are probably sub-optimal.
> charges via the microUSB port

The HP Chromebook 11 is not USB-C powered.
Can someone confirm my guess that this is only useful in very low density regions? My impression is that cell phone data rates are limited more by how dense you need to make the cells to cover the number of users in the area (so NYC has microcells everywhere) rather than the area over which some coverage is possible for a single user.
This is my thought. What percentage of the engineering grad school bump is non-US citizens? What percentage of people who go to law school are non-US citizens?

From purely anecdotal experience, I would guess that a significant portion of the rise in grad school attendance is from international students.
That's a great idea and really focuses on the do one thing and do it well approach. Are you going to have some app where they could scan the barcode of the toy and get the info or is it all manually input?
To Cloud or Not to Cloud? (2013)
The sad fact is that most news sites are very intentionally optimizing the minute details of their pages to generate the most ad clicks possible.

The problem of confusing pages that trick you into clicking ads - which, as has been pointed out, is an issue for many non-elderly people as well - is not one of usability ignorance. It's a calculated business decision.
My guess is that the author, who is a journalist, wanted to distance himself or herself from the content and not be associated with it; making it multimedia puts him or her among the technocrats while allowing them to write whatever they want. It also has the (actual) effect of being more engaging for decision makers. (So much so that it leads with a note saying it's only the author's opinion, not cnn's.)

probably many people here would not have read through a straight article with the same information. It's also more engaging and real - e.g. the video stories.

Edit: also the whole article is about the contrast with silicon valley. so having a new app-y interface to play with every second of the reading puts that contrast especially starkly. it certainly worked on me. (if I had read the same article in sfgate in the usual article format I dont think it would have had the same effect.)
Watching ideas flow from the Clojure/Script community back into Javascript I'm reminded of the positive impacts the Rails community had on Java web development. I guess we're at that point in time with respect to Javascript.
Ahh...so as soon as we posted it seems like the site stopped loading and now it's acting strange. We're scaling it up now so the link should work in just a few minutes! Oops. Well, thanks for showing us there's something we need to fix, everyone! ^_^'
I don't think that it is possible to test the skills that matter for writing real-life, maintainable code in a few hour's interview.
I think they're just less afraid to break things.
Arrow keys worked fine for me
What happens when on-premise HPC ends?
That's what Software Collections are for.

http://dev.centos.org/centos/6/SCL/docs/#chap-RHSCL
I got something very different out of it - it reminds me of Auftragstaktik, or leading by mission. Instead of adding explicit restrictions on employees, give them freedom of action. It takes trust that they're the kind of person that would make the kind of decision you want. In other words, having a shared "adult" background.
It skips some important points. The cost of living is high due to zoning laws and a lack of building. Subsidizing families' rent will just make existing landlords richer. It would just drive rents up further. What is needed to get fewer people bidding on the same unit. If landlords are finding <1 suitable tenants per vacancy then suddenly it becomes a renter's market.
It's even worse than that: not only does she need to login, she needs to remember a separate username and password for each site (which, good luck), or she needs to use a password manager. And if she uses a password manager, she needs to know how to select a usable/secure one, load her passwords into it, integrate it with her browser, sync it across all her devices, keep its contents secure... which, good luck.

In practice, of course, Betty will do neither of these things; she'll just use the same username and password everywhere. So then it's just a matter of time until a hack on one of the sites she visits opens her up to all kinds of new problems.

Username/password authentication is so, so utterly broken.
You may consider the Dell XPS13 when the Linux edition comes out. See http://bartongeorge.net/ for status updates.

I too am shopping for a Linux laptop. It can be tough.
Interesting to hear - would be interested to hear someone utilizing more of the selling points - distributed queries, etc.
Thanks! Yes, I'd like to get there at some point, but right now I'm just using an API to do product search based on name, UPC or others.
Well, now I have a tab that I cannot close. The whole browser is working correctly except for that tab.

Edit: Chrome, osx

Edit 2: Since I never close my computer and never close my chrome, I've pinned the tab so it's smaller. You have plagued my life for ages.
Isn't the simple obvious solution just to build a lot more housing? More supply means lower prices.
You think it's low?
You can try Caret, which is a very nice editor, and Zed, which works with Dropbox. However, you will not be able to do much (if anything) with Docker without going into developer mode, and even then it will depend a lot on whether this model will break Crouton in any way.

I'd say the tiny amount of storage will make it really hard to do anything productive with containers...
Push for policy changes that allow for the addition of enough housing to bring down prices.
The Challenge of the Planets: Invention of Gravity Assist
I don't really use this word or feel the need to participate in discussions about people it represent, but for me, when I see it somewhere, "brogrammer" means an equivalent of "cool people" from high school. Existence of them became possible due to programming becoming lucrative, with plenty of easy learning material, and therefore, beneficial for people you wouldn't at all consider a nerd to learn. It's a programmer who comes from outside of nerd culture, who looks at it like a cool kid from high school looks at school nerds.

It has also a bit "hipsterish" connotation - brogrammer is someone who's "not really into it". "The true nerds" were programmers before it was cool.

At least that's how I understand this term. "disliked man in the tech world" is much too broad, as so called "brogrammers" are supposed to dislike "true nerds".