skysight-inc/HackerNews huggingface dataset:
http://calicolabs.com

http://humanlongevity.com

http://genopharmix.com

http://sens.org

http://buckinstitute.org

See also:

https://www.youtube.com/watch?v=V48M5j-6zdE

and

https://www.youtube.com/watch?v=jbYgza4NNk8

To name some of the top roadblocks:
- Cellular garbage collection

- Inner-workings of Mitochondria and cell death/apoptosis at the wrong time.

- DNA repair genes

- Telomerase production/use

Analyzing genomic pathways associated to these is key. Understanding why the expression of genes varies or decreases/increases at the wrong time is also key.
Being able to use Cogntive computing/biomicry/AI/Machine Learning etc to analyze the hidden connections and relationships between phytochemicals, genes, proteins, pathways and environment is the next frontier.
We're working on it and could certainly use additional crowdsourcing approaches.
I also have this issue. Also, on three separate occasions one of my accounts has just disappeared and I've needed to re-add it.
Nfographic: 15 Years of the Apache Software Foundation
I think your question is a little bit disingenuous, as you knew this already

No, it was quite genuine. I am not deeply familiar with Arel.
There are a couple of good options for working with truncated blockchains to a checkpoint without reducing the security of the blockchain. Likely one or the other with settle out as the common practice, and the blockchain growth problem will be solved.

Power consumption, on the other hand, may not be solvable even in theory, and it also seems likely to drive mining to just large service providers. The current pools aren't a solution in this case because the startup cost to even participate meaningfully will grow too large.

Maybe this could be solvable with a different proof mechanism. A few have been suggested and tried (PPC etc.), but I don't think it's solvable for BTC as it's currently defined. I'm happy to be proven wrong.
Thanks for the reply! Just so I understand, the third party doctrine and pen register precedents are what these programs rely on? If so, why haven't they been defended on such grounds?

The EFF, ACLU, and now Wikipedia have a whole bunch of lawyers who strongly disagree with your assessment, but they have been unable to argue these points in an adversarial court because the Executive has resisted even addressing the question. If the Executive's opinions are backed in strong legal precedent, it would save everyone a whole lot of time if they just got to those points.
This.

Also, it's often better to just take the easy 3 pins from the greek church (especially after a strike) instead of risking a complete miss by trying to cover it. Covering the 3 after a strike is +6...missing completely is +0.
> Anyone who is interested in this, should read how that is implement.

Are is it implemented? my understanding was that it retains 4 copies of the entire heap in memory and continuously switches between them, or something like that.
Unsurprisingly, of course.
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I don't think that's it. One should worry about toxic choices. I just don't think a culture of asking people out is toxic. Something I do find toxic is an environment of conformity that imagines itself so fragile that it overreacts to the slightest deviation from what those in power say as if it were an existential threat.
sure, but they're more like screens that can be looked around or removed.
> I'd like for shy men to still be able to hear the worst thing that'll happen is "she'll say 'lol no, loser'", but now the worst thing that can happen is she'll be so offended she'll throw a fit and publicly name you and destroy your career.

Context is important. Asking a stranger out for a date at a bar has a worst case scenario of hearing "no". Asking someone out whom you just rejected for a job listing has a very, very different worst case scenario.

For fuck's sake, did I really have to just spell that out?

> why should sociopathic lawyers get to decide what risks are actually there or not?

Sociopathic or not, employment lawyers have a lot to say about liability and risk for business because they know the relevant laws very well and know how to make persuasive arguments in court for corner cases where precedent isn't entirely clear.

Again, did I actually have to spell that out for you?
> Open offices instantly "out" anyone who comes late, leaves early, takes a 2.5 hour lunch breaks, or surfs the web instead of working.

Looks at HN karma. Yeah, if only they did that.

I guess a lot depends on company culture, but I'm yet to work in an open-office space where I could actually focus on anything harder than the most mechanical coding tasks.
I studied calculus on my own in high school because there was no course in it. After learning about integration for a few days, I reinvented the idea of repeatedly doing a definite integral over several different variables of a multivariate function, and within minutes confirmed the formula for the volume of a sphere from its radius. Sometimes people just need a hint in the right direction.
Won't keeping the pragma be a useful signal for the compiler to know it can use the more efficient language subset? Those that don't support it can just ignore the pragma and go with standard Javascript.
Thanks for the reminder. I never clicked through to my location history before, even though I abstractly knew it existed. Quite an eye opener seeing your daily movements plotted on a map.
In a compiled language like C#, "wrapping" SQL is a good idea, at the very least to catch bugs at compile time rather than runtime. Also makes it easier to switch from one DB provider to another if you need to.

You are less likely to suffer from SQL injection if you use at least some kind of wrapper, although a minimal wrapper that takes a SQL with placeholders and arguments would do for that.

My preferred way to wrap is to use EF with a dash of Linq, which is excellent and yields great readability and flexibility.

There is no way I am going to be willingly writing SQL statements in production code (unless I am forced to do so by some legacy problem). Worse case if the SQL is so complex that it is too much for Linq, then write a stored procedure.

Back in 2002 I had to write hand crafted SQL before mainstream ORMs and at the time I thought it sucked bad! I was looking for ways to generate the code from schema but didn't have time to go and back-fix all the legacy code ad-hoc SQL statments!
It's also worth noting that this guy is working off of a built-in reputation system, while the question is just looking for a syllogism recognizer. The questioner can go play with Coq if that's what they're looking for.
> You don't hire 10x just people who make other people 10x? Then that person you just hired is 10x.

The point was more that I value a person's ability to lift those around them much higher than their abilities to outperform them. It's hard to scale one person. But one person who can help scale an entire team is infinitely more valuable.

> In simple business terms you have a guy who'll get you sued for 1 million but will make you 10 million.

He's not a liability because of potential lawsuits. He's a liability because he brings the team down (antics like this do have a huge impact on the rest of the team).
Alternatively, check out all of the free tutorials on YouTube: http://www.youtube.com/devfactor
"""The interfaces require the end-user to know about the concept of a table, rows and columns, the concept of logical expressions, as well as aggregation, even though none of those are directly visible nor have a ‘real life’ analog."""

This sentence expresses the problem I see with designers.

Instead of making that disappear into magic why not focus on actually purposely and clearly educating people about these CORE concepts?

edit: Think of how you would do this if you were Khan academy...
I personally prefer SQL + Dapper instead of ORM stuff if it is Linq-level SQL, and sprocs w/ Dapper otherwise.
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Why would it not have applied to the Tsarnaevs?

I did read that link, along with many other linked pages from the original link.

See here: https://www.aclu.org/national-security/president-obama-signs...

And here: http://www.salon.com/2011/12/16/three_myths_about_the_detent...

There does seem to be a lot of debate on this topic regarding the wording of the bill and how it applies to US citizens. However, to me, the wording seems very vague and open to interpretation. Which was likely on purpose.
Ecstasy and other drugs are now legal in Ireland (but only until Thursday)
Here's another way of seeing it: if your target tick rate is 60Hz (~16ms), when the GC decides to trigger a collection, you lose most of your time budget. You'd have 6ms left on average, sometimes less, so to avoid dropping any frames you'd probably want your tick routine to complete in 5ms. In other words, when it comes to work that must be done every tick (which is probably most of it), you could only safely use less than a third of available CPU time!

I guess dropping a single frame on occasion may not be that bad, and the GC parameters could be retuned (and other GC languages have lower latency), and you could minimize the amount of garbage created, but still, that's not a good situation to be in.
Since it's also used for array access, it introduces another ambiguity in the grammar there.
Are there any updates to this story? How is the de-ratification going? A few searches did not turn up anything that seemed like a useful update.
Weirdly enough, I like the way it slows down after switching tabs.
> I am regarded as Not Notable Enough For Wikipedia for the specific reason that I feel that no one should have to pay to read my essays and articles

That substantially misrepresents the reasoning given in the deletion discussion: http://en.wikipedia.org/wiki/Wikipedia:Articles_for_deletion...

It wasn't that your work was self-published that made you non-notable, its that there wasn't substantial outside coverage in reliable secondary sources that would justify a biography.
How is notifying the Iranian government that Obama doesn't have the power to make any deal without their approval a violation of the Logan act?
Do they really care about smartwatches if they are suddenly making their app work with the Apple Watch?

I bet this is just publicity, otherwise if they really cared about smartwatches they would already have their app working with Android Wear.

Either that, or it's CEO blindness again, thinking only Apple exists. ;)
> I'm sorry, but I'm going to have to point out that your comment doesn't respond to mine in any way.

Hmmm... you said " you need to have a ready response to the extremely obvious observation that the Internet seems to function pretty OK without DNS security "

I gave you one example. Here are some more:

- There are now over 800 XMPP servers with DNSSEC-signed SRV records that can be used to ensure they are talking to the correct servers. https://xmpp.net/reports.php#dnssecsrv

- On a related note, there are over 300 XMPP servers using DANE to provide a higher level of trust to TLS certs: https://xmpp.net/reports.php#dnssecdane

- There are now over 1,000 email servers using TLSA records (DANE) to provide a higher level of security to the TLS connections between email servers. (Viktor Dukhovni of exim)

These are very real cases where adding DNSSEC is, to me, increasing the security of DNS.

Because I'm around examples like these, I see value in securing the DNS. So to me, "doing nothing" is not an option.
I'm glad that you feel that way! I'm a big proponent of work-life balance, so being able to be productive enough through the day so I can leave without feeling guilty is a huge plus. I wish more companies held similar views.

Hopefully, if there are enough productivity gains and as the startup transitions out of super-lean mode, you could represent that increased productivity with a shortened work day/week!
I reject this assertion that people get ripped "out of the zone". What are you doing that is so complex that you can't jump right back into it?

I've met plenty of people that like to act like they're some super elite programmer that is juggling complex class structures and debugging them inside their head. In my experience so far, those people are full of shit and make overly complex spaghetti code. Idk though, maybe this is different between web development and something like game engine development.
The middle ground is small group offices, and many (most?) people are fairly happy there. Actual giant open-plan offices can be distracting beyond what's tolerable.
Someday, maybe someday, we'll have a calendar app smart enough to show a month view and NOT anchor it to the first day of the month.

Look at the calendar in the App Store screen shot. It's February 27th and 4/5 of the month view is showing days that have already passed. The week ahead is totally lost because the next week is in March.

UX-wise is there something disorienting, taboo, or just plain illegal about centering the current week in the middle or top 1/3 of the view? Because this just sucks. And it never changes. It happens in every calendar app that has a "month" view, and it's the most unusable the last week of the month (which is, oh, 25% of the time you use it).

Apple is just as guilty (looking at you, OSX Calendar).
SQL databases had their imminent death coming. They were stuck. However, PostgreSQL is under more active development than most other databases, SQL or NoSQL. It is new and cool technology.

In the end, whether you speak SQL or use NoSQL construct matters as much as whether you write a program in C or Pascal. You can have endless debates about form and function and you might want to see and identify with a winner, but in the end whether the tools and the community surrounding a technology fits people's needs is the only thing that really matters.
SiteSpect is hiring in Boston & San Francisco: Advanced Solutions Engineer (BOS & SF), Solutions Architect (BOS & SF), Web Optimization Consultant (BOS & SF), Product Manager (BOS), Marketing Manager (BOS), Marketing Coordinator (BOS), Sales Engineer (BOS) and (soon to be posted) NOC Engineer (BOS). All San Francisco roles are REMOTE to start.
Check out our openings here: http://www.sitespect.com/about-us/careers
SiteSpect is a privately held company that has bootstrapped since its inception in 2004. We received our first round of funding in January 2015 and we’ve earmarked a bit of it to invest in what we consider one of our most valuable areas - our talent.
SiteSpect provides the world's only non-intrusive optimization platform, enabling businesses to significantly improve key metrics such as conversion rate and engagement. SiteSpect's solutions include rapid A/B testing, multivariate testing, behavioral targeting and personalization, landing page optimization, mobile web optimization, and web performance optimization. Our services are used by many of the world's leading online, fortune 1000 businesses, such as WalMart, Target, Urban Outfitters, Wayfair, Overstock, Trulia, etc.
I am SiteSpect’s first in-house recruiter on staff so I am choosing not to disclose salary ranges at this juncture since I have only been here 3 weeks and don’t know how that would be received, however, I will happily discuss this with you if you reach out to me. I can be reached at eakeroyd@sitespect.com or via LinkedIn https://www.linkedin.com/in/eobrienakeroyd.
Thank you!
If it is some percent unreliable the other percent doesn't change that. It's not just OS X, it's also iOS, Maps, iCloud etc, some of this stuff was famously bad. There's been a lot of discussion about this recently with many notable Apple enthusiasts chiming in - https://www.google.com/search?q=apple+software+quality.
"Le sigh."

This doesn't mean it was stored in plain text. There are plenty of 2-way encryption schemes.
I mean, I grew up in California, not even remotely rat free, and I think I've seen... three-ish... rats in my nearly 40 years? Besides pets or lab animals.

Rats hide. Doesn't mean there aren't a fairly large number of them around.
> 3D wireframe beehive.

while progress can't be stopped, it is possibly to capitalize on it - i think you should file a patent together with the other guy who mentioned beehive :)
Male medical students are more confident and more wrong
That's not a whale. A whale is someone with a lot of money and willingness to dump it into your pocket when giving the right incentives.

I get what you're trying to do, but the terminology is not only wrong it's insulting to the users with whom it's most critical to maintain a good standing with. If anyone discovered I was doing something to influence their opinion of my apps based on the fact that a service tagged them as a "whale" i can pretty much guarantee they'd spread NEGATIVE influence about my products and myself.
I initially went back to it over the way systemd was handled on Linux. Nowadays, I've really grown to appreciate the minimalism and the slower, more thorough pace of advancements. I find that being too cutting edge just tends to lead to more problems in production. I also really like the development model, and most design differences I read about (one quick example: /dev/random behavior) more in the BSDs. Lastly, lots of features I like a lot more. ZFS over btrfs, pf over iptables, etc.
Curious, has anyone adopted another company's published style guide?
... and real science also works off a reputation system.

If everyone did nothing but check everyone else's results, there would be no progress. While we don't trust first-hand original research, we do place trust in third party validations of research.
Shanghai Metro Flow
In practice there have definitely been perf losses from "use strict" (emscripten used to emit it until we noticed that). "use strict" sounds easier to optimize - it's stricter - but in practice, JS engines didn't get around to optimizing it, at least that was the case a few years ago.

There have also been breakage issues. "use strict" changes semantics. Before all browsers implemented "use strict", some had it and some didn't, which meant scripts with "use strict" ran differently in different browsers.
Why would it make sense to encrypt queries and replies from a public data source? Signing the data is all that is needed.
> Agreed that there is a lot of scope for doing better on BGP security, though

Yes... and there we go down the path toward BPGSEC, RPKI and other tools that people are developing to help secure the routing infrastructure.
I thought your first sentence was sincere, but your last implies otherwise. I don't think everybody received this email.

We should be happy that WordPress didn't hide this fact and came clean by informing users. Of course, the email doesn't list when they noticed your password (or other passwords) recorded in plaintext, but at least it's been identified and steps taken to address the problem.
Another negative about open office plans that I don't see people mentioning is the hearing loss due to having to wear headphones up to eight hours a day. Headphones are generally not recommended to be used more than an hour a day and even then, they need to be at a low volume, something that's impossible in the open-office plans I've seen/worked in.

"As a rule of thumb, you should only use MP3 devices at levels up to 60% of maximum volume for a total of 60 minutes a day" (http://www.osteopathic.org/osteopathic-health/about-your-hea...).
I switched a new product in planning from MongoDB to PostgreSql 9.4. With the new JSONB columns you get the best of both worlds.
Thanks guys. I definitely will start a side project and start working out.
Transparent glass screens. So that you have no walls and no visual separation, and yet can still work.
Many banks have apps that will send notifications on every CC charge. I have at least three (CapitalOne, Wells Fargo, AMEX).

It's more useful to see your spending habits than safety. After all, a stolen credit card isn't really worth worrying about when you're not actually out any money.

With CapitalOne I have the opposite problem, in that they keep declining charges and sometimes closing my card for purchases I did actually make myself.
At Knewton we used (use?) Google's Python style guide.
SiteSpect is hiring in Boston & San Francisco: Advanced Solutions Engineer (BOS & SF), Solutions Architect (BOS & SF), Web Optimization Consultant (BOS & SF), Product Manager (BOS), Marketing Manager (BOS), Marketing Coordinator (BOS), Sales Engineer (BOS) and soon to be posted NOC Engineer (BOS). All San Francisco roles are REMOTE to start.

Check out our openings here: http://www.sitespect.com/about-us/careers

SiteSpect is a privately held company that has bootstrapped since its inception in 2004. We received our first round of funding in January 2015 and we’ve earmarked a bit of it to invest in what we consider one of the most valuable areas - our talent.

SiteSpect provides the world's only non-intrusive optimization platform, enabling businesses to significantly improve key metrics such as conversion rate and engagement. SiteSpect's solutions include rapid A/B testing, multivariate testing, behavioral targeting and personalization, landing page optimization, mobile web optimization, and web performance optimization. Our services are used by many of the world's leading online, fortune 1000 businesses, such as Walmart, Target, Urban Outfitters, Wayfair, Overstock, Trulia, etc.

I am SiteSpect’s first in-house recruiter on staff so I am choosing not to disclose salary ranges at this juncture since I have only been here 3 weeks and don’t know how that would be received, however, I will happily discuss this with you if you reach out to me. I can be reached at eakeroyd@sitespect.com or via LinkedIn https://www.linkedin.com/in/eobrienakeroyd.
Why does the apple watch exist? Who knows
http://www.nickbostrom.com/fable/dragon.html

This was an interesting read about humanity's perception of mortality.
This is all a poor excuse. The government should seize her personal servers immediately and look through the emails.
One opinion of course. Already blew away Sunrise, absolutely love the new Google Cal app.
Really cool toy! I wonder how the randomizer works, does it use some predefined scale or some other heuristics to always end up with something nice?
The machine will become a $2k paperweight if that port is rendered unusable.
http://en.wikipedia.org/wiki/Attention_deficit_hyperactivity...

Adults have it; amphetamines help but don't cure it; the ADA requires reasonable accommodations for it.
The point of "use strong" is to enable optimizations that wouldn't be possible otherwise, among other things. If you remove it in production, you won't get the optimizations.

"use strict" is used in production all the time. Google and Facebook use it. The Babel transpiler (formerly 6to5) adds it to your code by default.

It's one thing to get JS programmers to write their code in a certain way, but if the VM knows they are doing so, it's even more powerful.
Our open office of ~30 developers and engineers is fairly happy, once we got managers out of their offices and stuck the noisy client services/salespeople into the offices.
The weirdest things, like the funniest things, are neither intentional nor the product of conscious effort. They surface despite attempts to suppress them.

I'd also argue that weird is not necessarily synonymous with unusual. You can achieve unusual by traveling a little farther along any metric you want, including conventional cool values like athletic prowess or symmetric beauty.

Weird is more than unusual. It is the irruption of some aspect of life that gives us an eery feeling. It's Blue Velvet.
Pyhipku – Encode any IP address as a haiku
So what is your alternative for solving DNS poisoning?