skysight-inc/HackerNews huggingface dataset:
This is a really great point srunni thank you for bringing it up. We agree that the current approach to identifying predictive cancer biomarkers has many challenges. That's why we believe in a different approach.

Glioblastoma was actually the first tumor profiled for the Cancer Genome Atlas Project.
http://cancergenome.nih.gov/cancersselected/glioblastomamult...

There have been four subtypes found in the disease, but all four are still treated ineffectively with the same standard of care chemotherapy (Temozolomide). To date none of these predictive biomarkers have led to a successful targeted therapy.

This was a personal frustration for me, as I had my dad's tumor sequenced for genetic mutations, but there were no targeted therapies that reach the brain in high enough concentrations to be effective.

This is an important distinction in personalized medicine specific to brain cancer, as many drugs do not cross the blood brain barrier. For example the most prevalent mutation in Glioblastoma is a mutation in the Epidermal Growth Factor Receptor (EGFR) pathway. This is also a driver mutation in lung cancer that has approved targeted therapies like Afatinib.

Unfortunately none of these drugs have worked in trials for brain cancer, in large part because they do not cross the blood brain barrier well. For example here is a study recently published on the poor results with Afatinib in brain tumor patients.
http://www.ncbi.nlm.nih.gov/pubmed/25140039

There are currently very few targeted therapies in development for brain cancer as it is a small disease for pharma companies to market drugs.

This is why our approach is to correlate tumor response to existing therapies with empirically identified biomarkers. In contrast using tumors alone to predict cancer biomarkers is challenging because it requires a hypothesis or target to be tested one at a time with a novel therapy in a trial.

For underserved diseases like glioblastoma, this could result in many years passing by as each hypothesis driven therapy fails in clinical trials.
Yes yes, but can I run windows on it?
Seriously :), can you boot windows using Pixel bootloader?
Elizabeth Warren says Pacific trade deal alarming ‘for everyone’
Research and Development. Two separate tasks.

Research, breadth, trying many things, 95% of time spent trying and failing.
Development, depth, taking the most promising 5% of research and doubling down.

I want my research Chief Officer to continually try new things. I expect them to give me 19 bad ideas for every 1 good one. If anyone in this division is afraid of failure, they are in the wrong division.

I want my development Chief Officer to succeed, and the culture of fearing failure is perhaps more appropo in this tribe.

I wouldn't spend money on research if I didn't have a development budget ...
Actually, since you keep talking about energy, you brought to my mind a critique of some textbooks by Feynman: http://www.textbookleague.org/103feyn.htm

I turned the page. The answer was, for the wind-up toy, "Energy makes it go." And for the boy on the bicycle, "Energy makes it go." For everything, "Energy makes it go." Now that doesn't mean anything. What they should have done is to look at the wind-up toy, see that there are springs inside, learn about springs, learn about wheels, and never mind "energy."...Now that doesn't mean anything. Suppose it's "Wakalixes." That's the general principle: "Wakalixes makes it go."...It's also not even true that "energy makes it go," because if it stops, you could say, "energy makes it stop" just as well.

I claim that this critique applies equally well to your use of the word "power".

And your comparisons to real sciences are quite inapt - again, as I've pointed out to you before, a discussion with tptacek on crypto or kasey_junk on high speed trading results in the aforementioned posters being very specific while their critics are vague. Kind of the opposite of what is happening here.

Note that you still haven't actually provided an experiment or measurement that could identify a successful yet powerless group (if such a thing existed), or vice versa.
outside the rest api, mostly crawling 3rd party apis, basic map-reduce aggregations, data sanity checks, the occasional s3 dump. No fancy distributed systems or machine learning stuff everyone else seems to be doing. How about yourself?
Yep. Subscribing to the New York Times is just as viable of an option for getting the news as it was in Betty's youth.
Preprocessed prepared queries that are shipped along with whatever package is using them is a far easier solution than quirky ORM tools that can do the simple things, but have a tendency to break on the harder things or encourage an authoring style that destroys performance.

That said, I think the world could use a CoffeeScript-esque transpiler for targeting SQL. Preferably with some kind of frontend/IL/backend separation, so that everyone can take a crack at replacing the awful SQL syntax.
There's even a trend for US grads relocating to developing economies. A lot of us (me included) have found very interesting work/life arrangements in places with lower taxes, lower rent and higher salaries (relative to cost of living of course). There's even a smallish trend of people expatriating to avoid crushing student loan debt. IMHO I'd expect that to increase.

http://money.cnn.com/2008/10/23/pf/college/student_loan_fugi...
What is the difference between a laptop designed for Windows and one designed for Linux? Apart from device drivers (graphics, Wi-Fi, bluetooth) which are usually not a problem, I can't think of any difference. Perhaps Linux might not look very good on very high DPI screens, but that's it.
No offense taken. I use noscript to whitelist websites and grant temporary permissions to others as needed.

To clarify, I have no problem with you using JS. I know I may have to enable it go gain functionality sometimes. My gripe is that on your sites I get zero functionality without it.

I don't mean to cause offense either. Thought it may be something you hadn't considered is all.
Software Testing from the Perspective of a Hardware Engineer
The author said they used Mongoose to define the schema, and since they needed to define the schema, they'd rather just do it in the database. So I don't think they'd have been limited by using SQL from the start. Either they learned how to evolve a schema or they didn't have a schema that evolves well even when they were using MongoDB.
Yeah, getting the main feed right is a general issue for Facebook.

If someone really wants to know about a few bands in particular, liking some of their posts will cause more of their stuff to percolate up into the main feed. But they have to keep liking.

To see all posts from bands one can make an "Interest List" containing the bands. Posts from members of that list will show chronologically. But I don't think showing all posts is the solution to getting users the info they want.

What happens if a band page creates a Facebook event? Does the event get recommended to likers nearby the event? That could be an approach.

Author is probably correct in that Facebook needs clear guidance here.
A world where people use real servers.

All of our physical boxes have 256gb+ of RAM.

They run VM's via XenServer for most of our uses, but our production DB's run on bare metal as they need the RAM and disk performance.
Suspicious account, a little...
Thanks for your patience! Working on it as fast as we can.
Things every JavaScript developer should know
That recall doesn't cover this item; this item's model number is 440-B, but the recalled ones are "439-A, 439-B, 439-G, 439-P and 439-W".
This looks very very cool. But, who is the target audience here?

IMHO, this doesn't have the best Product/Market fit. I'm guessing the target is a non-programmer or just front-end guy who quickly wants to put together a backend.

If that's the target, then why not provide a set of generic backend functions. For the mentioned target.

I think you can limited to a simple set like: registration, authentication, user profile, follow (friend), add content (text, image, video), like, list content, list all liked, list friends, etc.

This way you can become "Wufoo for backend".
ZeroCater (YC W11) Is Looking for a Product Manager
ZeroCater is looking for its first Product Manager to help us build products our users love and take us to $100MM revenue and beyond. The ideal candidate is actively curious, incredibly bright, highly organized, and has at least two years Product Management experience.

RESPONSIBILITIES:

- Own the immediate-term product roadmap.

- Define and manage detailed software and feature specifications

- Own features and products end to end

- Develop a deep understanding of our customers and business operations

- Stay current on the competitive landscape

- Plan for the long term success of the company and keep an open mind for long term opportunities

ABOUT YOU:

- 3+ years working as a Product Manager at a startup or tech company

- Excellent product judgement

- Analytical mindset: prefer to resolve questions through data and measurement

- Deep empathy for the user

- High level of organization and attention to detail

- Strong interpersonal skills

- Great communication/facilitation skills.

- Computer Science degree or equivalent programming experience preferred

To apply, send a note about yourself to jobs@zerocater.com, along with your Github username, portfolio, resume, or some of your work.
Could you clarify this statement? Independence is defined in terms of distributions (the joint distribution can be split up into a product of marginals), so I'm not sure how "the way a set of data is distributed" and "can never imply independence" jive.
I don't agree with everything in the article but thought it was worthy of discussion
New-less JavaScript (2013)
Auditing and fixing the original still improves LibreSSL, although one of the main goals of LibreSSL was to clean things up to make that easier.

Last LibreSSL release was 2.1.4 last week, although a minor update should be coming soon. http://marc.info/?l=openbsd-announce&m=142543818707898&w=2

LibreSSL is going to track OpenBSD versions, so now that OpenBSD 5.7 is done, the LibreSSL 2.1.x series is done (except to receive patches). At some point a 2.2 release will be made, corresponding to new developments.
The Ultimate Checklist to Make Money Online as an Affiliate Marketer
This is the only answer that makes sense. You got the funding already, just run along with it.
I'm viewing from Australia. Can anyone in the US confirm whether there is or isn't Chromebooks on there? Seems a noteworthy omission, if not.
Great question! Open source drag and drop functionality currently exists for things like sending emails (via mailgun or mandrill) payments (via stripe) sending SMS (via Twilio) social auth (via twitter, Facebook, or github) password encryption (via bcrypt) analytics (via segment.com) and over 100 other common functions
But then the requirement that the rv's be jointly normal is violated. The "jointly normal + uncorrelated" combination is special. There aren't too many other named distributions that have the property that uncorrelated implies independence.
>I knew people like that too, though I can't tell how often it was because they were just jerks with technical interests, and how much it was a defense mechanism, trying to maintain a little bit of self-esteem while being constantly bullied.

Yeah well 9 times out of 10 the "jocks" who bullied the "nerds" were doing it out of a deep seated insecurity too. Just because someone self identifies with a subculture does not mean they are any less capable of being an asshole.
Difference between Echo and Print in php?
There's [0]hull.io, doing a lot of the things you've mentioned here.

[0] http://hull.io
> Not to say that situation isn't bad, but you can't compare it to C++ because nobody ever thought running untrusted C++ code without some other sandboxing was a good idea.

This is actually kind of a point for the other side. You can sandbox code regardless of what language it's written in. Maybe what we need is not better languages but better sandboxes. Even when code is "trusted", if the developer knows it doesn't need to e.g. write to the filesystem or bind any sockets then it should never do those things and if it does the OS should deny access if not kill it immediately.
Interesting comment particularly given Thiel's own views on monopolies.
How to know if you might be a customer: Did you make a mockup that needs a backend but have little backend coding experience and are sick of including a bunch of the same libraries? If yes, maybe.

In short, they're integrating some commonly used API's and backend programs (Elastic Search etc) and putting a graphical programming model on top of it.

Crappy backends are pretty easy to throw up on a VPS or Heroku these days. It's so easy that I'm likely to select an app server(s) and language based on what library (if any) is most critical to that particular request type.

At first I wasn't sure who the target customer could possibly be. Was it a PaaS service? BackendaaS? A service like this lives in a weird space. It's almost only good for early product dev and when the team's backend devs are green.

Things like having unit tests, scale, completely custom capability etc will drive everyone who makes a successful product out at the very time that they can start to afford paying a lot.

Don't burn all your money yet ;-D
Consider that the author spent one short paragraph to talk about the OP's choice of pronouns, while you spent an entire comment taking her to task for it; that her criticism was politely stated, while you employ rank hyperbole in describing that comment as "[destruction]"; that you're expecting someone to be polite and dispassionate who by her own admission has dealt repeatedly with the litany of disappointments and frustrations that come with being a woman in a male-dominated field, while not even meeting that standard of even-handedness in your own comment; and then maybe reconsider how you're devoting your efforts in this conversation. From here it looks like thou dost protest too much, methinks.
Universal Special Auto Finance for Bad Credit
I was a journalist covering Ebola in Liberia. Then I caught the virus
Deployment system relies on sails deploy- Microsoft actually just contributed an open source deploy strategy for azure and Heroku expressed interest in contributing to theirs. AWS has also been very helpful. Will keep everyone updated as things progress.
I think the idea is to bring this kind of scale to a wider audience at a lower price point.
Does anyone know how feasible it is -- using Crouton -- to setup one tab in Chrome that is a shell running tmux, vim, git, server processes, etc, then test the website you're coding on in another Chrome tab?

A lightweight dev environment like that on a cheap and light notebook is pretty appealing.
One week in Portugal with iPhone 6+
Ep 172: Jared Loftus- Prep for Success
To respond to a deleted comment about why it's important:

The claim is that it's open-source, not open-rendering. There's no thing you can insert a PDF into to be able to manipulate the design in a meaningful way.

Even as a visual reference, it's not very useful. Googling the the two main chips gives no useful search results. If you did manually recreate the schematic, you would still have no way of building anything with it.
I know I default to 'he', personally. I have become increasingly aware of it because I work in a call center at my college and I have to consciously refer to a parent's students as 'he or she'.
Yes, I cook sometimes. Frequency - about 3/week. If you count microwaving as cooking then I cook daily. I use stove, microwave regularly and sometimes I also use the oven grill. Most often, I use the stove to cook eggs and pasta. I am trying to get fancier with my food and make nice fish dishes and stuff. I expect I will use my blender and oven more frequently then.
to be heard, not seen
Sad (to some) but true.
Definitely didn't register that as a name until you mentioned it. I thought it was just clever alliteration of some reference that I was missing.

I feel silly now.
We Are LunarG, Funded by Valve to Improve SteamOS on Linux, Vulkan API, SPIR-V
Gerbers aren't design files, they're another rendered output.
just shut the computer and watch your kid. Eh, fcuking nerds
Docker CLI is coming to Windows
Thanks!

1. There are indeed similar efforts in academic labs around the world. The constraint they face is lack of funding to expand their experiments beyond testing drugs on their small sized tumor banks.

Industry labs don't generally have access to primary (from patients) tumors so they have to partner with academics or contract research organizations (CROs). No one institution or CRO has a Glioblastoma tumor bank beyond around 100 patient samples.

These smaller tumor banks don't capture the heterogeniety of the patient population as a whole, so one of the advantages of being a company not tied to an institution is the ability to develop a substantially larger tumor bank that accomplishes this. We accomplish this by acquiring primary tissue through our testing service around the world.

Academics also often rely on standardized assay conditions and commercially available cell lines because their major incentive is to publish their results. Standard methods and cell lines are often preferred by reviewers and working with primary lines is difficult and expensive. Translation to response in patients isn't the primary objective of the screens.

2. Yes, Elizabeth Iorns, a former cancer biologist and the CEO of Science Exchange, is one of the part time YC partners.
> the author spent one short paragraph to talk about the OP's choice of pronouns

which was completely unnecessary and added nothing meaningful to the discussion.

(In fact, it was self-contradictory given the insinuation that the OP had to be male in "I don't expect any different from this field.")
I'd argue a simpler reason is that the vast majority are male.

"Never attribute to malice that which is adequately explained by stupidity."

- As an aside, while I firmly believe that both genders have equal _potentials_, I think that due to various socioeconomic and cultural pressures, genders are _not_ equal at everything in execution, on average. It might take a while for that to happen.
Nobody would consider a print-out of the Linux kernel's source code to be an acceptable means of distributing it.

To the contrary, bound and printed copies of the PGP source code were used to get around ITAR export controls on crypto in the '90s.

https://en.wikipedia.org/wiki/Pretty_Good_Privacy#Criminal_i...
Circa on Android fulfills a lot of these criteria.
Anyone who wants to actually build the board. USB 3.0 is a whole new ball game and has lots of gotchas with board layout & design. Check out Jared Boon's Daisho talk for some good background on USB 3.0 challenges: https://www.youtube.com/watch?v=eTDBFpLYcGA&t=1059
Interesting to think about for sure. Facebook's algorithmic solution seems to be that to the extent that any post is a true draw to Facebook, that post will get more likes and thereby be more likely to percolate up into other users' main feeds. Boosting that post will therefore cost less. This provides sort of a sliding scale without pricing tiers.
Elon Musk is also spread rather thin and seems to make things work somehow. Eliezer's accomplishments are not on the same level but the one he's been working on for more than ten years is rather more ambitious. Even just founding a non profit research institute is an awful lot more than most people ever do with their lives.

And even if the chance of any of the things he mentions happening are very small any one of them would be awesome. Seriously, half of them could be the life's work of a very talented, intelligent person. If he gets more than one of the very ambitious ones up and running and then either does the Musk superhuman thing or hands it off to someone else I'll be very impressed.
Neither of those are cultures noted for their sensitivity to women.
As one of those people, I have to say taxes and prices are much lower in the USA than say china or Thailand. Especially when you get away from food and low end services.

I work in china but shop in the states on my visits back. As far as salary goes, I'm a bit below us levels but can save alot because I don't need, nor could I buy even I I wanted to, a car. Working in Swiss was like that also, things were just too expensive to buy so I was able to save alot.
Ease of routing.

I know optical on-chip networks have been the subject of research for many years, and I've heard rumblings of optical interconnects between chips. I don't know their current status, nor whether they look to be useful in practice. Hence my question.
While not usually meant for carrying high-speed signals, there are optical isolators[0] that are used to communicate between circuits that are not connected electrically.

I'd guess that fiber optics is only a net win over large enough distances that you make up the latency from converting electrics signals to optical and back.

[0] http://en.wikipedia.org/wiki/Opto-isolator
I've always meant to read this one, although I usually don't even like the idea of fanfics.

Reading just a bit, the constant "science!" is really off putting and I'm only half the chapter in. Just reading this [0] makes me want to close the tab. Is it this obvious and in the face throughout the whole 'book'?

[0]

> "Mum," Harry said. "If you want to win this argument with Dad, look in chapter two of the first book of the Feynman Lectures on Physics. There's a quote there about how philosophers say a great deal about what science absolutely requires, and it is all wrong, because the only rule in science is that the final arbiter is observation - that you just have to look at the world and report what you see. Um... off the top of my head I can't think of where to find something about how it's an ideal of science to settle things by experiment instead of arguments -"
If you're using mouse models to confirm cell culture results, roughly how long does it take to go from receiving the tissue sample to sending out a report to the patient's physician?

What type of responses to your reports have you gotten from practicing oncologists?
Yep, I have something vaguely similar to this which I've built over the years for my own projects, essentially generators for boilerplate for back end stuff, written with preferred libraries, coding styles, testing approaches, etc. From who I know, I think it's common for back end devs.

Yet I've never really built 'a simple' app... It does always requires substantial time tweaking, customizing, and building things that just can't be automatically generated. I can't imagine for anything that's not just dead simple that you could take the generators all the way.

But I see you're targeting front end folks, which makes sense. If they have simple use cases this could work nicely for them.
You already answered the question - "They will be thinking wildly" :)
when i type 'g', the autocomplete feature suggests 'gmail.com'. After typing 'g', i type 'oo' and the suggestion feature suggests 'google.com' on its own. I do not have to type the complete 'google.com'. i type 'goo' and then i can press enter
Disclaimer: I work with Harlan on the NTP Public Services Project and the NTP Foundation, but even I didn't know that the finances were this bad.
This is interesting, because lots of cheap clones of the adapter will appear and quickly drive the market price below $5.

There has been a dichotomy for several years: generic adapters are $2-$5, while proprietary adapters are $20-$50. It's not due to the BOM cost of the chip, which is probably less than the cost of the copper. This might be the first mainstream adapter with a chip, other than PL2302-based USB-serial adapters, that are cheap.