skysight-inc/HackerNews huggingface dataset:
Microsoft Band SDK Preview
What proportion of bases in your query were ambiguous? If it was a fairly low percentage (~10-20%?), I think you could probably get away with using LASTZ, treating all ambiguous bases as completely ambiguous (--ambiguous=iupac), then write a short script to go through the alignments afterward and filter out ones that don't have a reference base that matches the IUPAC character in the query.

But that's the lazy approach :) Good article.
Knowing the approximate file sizes and number of files in a directory, especially with further context of overall directory structure can allow someone to guess what the content is with high probability if the files are "well known". Consider a directory containing pirated episodes of a tv show, organized with a subdirectory per season. "Scene releases" tend to have one a few possible approximate file sizes, and depending on how much padding, it may be enough information to identify a set of files as all being scene releases of the same show. Many other examples like this - anything "popular" that's will have a fingerprint of extracted file sizes.
There's work I've started on this, actually. It's available in the README of the NtSeq repository[1]. Near the bottom. The probability becomes a mess (or at least, I can't figure out the correct model) when you start including degenerate nucleotides, and I didn't want to release a half-done statistical analysis tool, so I axed it from the current release.

[1] https://github.com/keithwhor/NtSeq
I completely agree. I find the Android APIs absolutely appalling.

My former coworker knows both iOS and Android, having done Android for many years, and he refuses to program for Android ever again. He would also tell me that the time it takes to implement things in Android is usually 1.5x - 2x longer than the equivalent thing on iOS
or http://wageoffer.com
The graph chosen here, the ratio of a toxic does to a typical dose, is a poor proxy for actual risk. For instance, cocaine has a relatively high risk of causing heart problems at "non-toxic" doses. GHB has a low ratio of deadly to recreational (though not so low that it's unmanageable,) yet is one of the safest recreational drugs.

This is similar to the British health leader's announcement that MDMA was safer than alcohol, entirely based on how much likely someone was to die, as opposed to other potential negative effects like neurotoxicity.

I'm a support of full drug legalization, and agree that most drugs are far less harmful when taken properly than alcohol. It would be great to see less obtuse statistical analysis of risk.
> How long would I have to study physics to be able to understand everything in this sentence?

Just start reading David J. Griffiths: Introduction to Electrodynamics. A very well written textbook. The problem might be, if you don't know vector calculus, you might not be able to read this book, so you need to learn some vector calculus, too.

Then start reading Introduction to Quantum Mechanics by Griffiths, too. Best introductory QM book that I know of. If you managed to read Electrodynamics, you should by now know enough calculus for this book, too. But you also need to know about complex numbers here.

The "inviscid compressible fluid" is about fluid mechanics. I don't know any splendid textbook on that.
Low tech 'visual hacking' successful nine times out of 10
Its interesting in that here is potentially another $2B going into data centers, if you look at Google's results you see they spend 1 - 2B$ per quarter on data centers (so call it 5 - 8B$/year). Facebook, Amazon, and Digital Ocean as well.

The co-location business is practically toast though.

Back in the early days I felt sure that nobody would put their core business assets on computers that someone else owned and operated. After all if you have physical access you have all the access you need. Why put your business at the risk of one disgruntled AWS admin?

But time has proven my thoughts to be incorrect. I find that quite amazing.
I was hoping for a decent replacement for osx file manager and window manager.
Show HN: AllJS – Popular JavaScript libraries ready for tinkering
I'm not 100% sure what you mean by rule engines.

I tried to use a FSM for a SPA that was developed with Backbone.js. First it was really useful, but it was really shitty to maintain(expanding etc), though that maybe was fault of implementation. Still it is interesting idea, that I might want to try again.
Except this is totally reinventing the wheel.

If I want to do fast genome alignment, I'll use lastz which is already blazing fast and written in C. If I want to just look for homology, I'll use blast.

There isn't much need for improved alignment algorithms. If it's a big job, most bioinformatics have access to clusters. If it is a small job, who cares about speed.
Nifty game! If I may offer one suggestion, though: it's generally a dealbreaker for me if a game does not provide an option to disable sounds.
Hacker News, 2007 Edition
Repost of my reddit rant about UX issues in this visualization:

This is interesting, but the layout is pretty confusing for somebody who studies poker.

Every other hand chart has AA in the top left, like these from Poker Stove: http://i.imgur.com/cvgvh.png

Also, yours have duplicate information. As2d and 2dAs are both displayed, when in fact they are equal in poker. Most charts split up suited and offsuit hands, like the ones above or this one from Equilab which lists out every combo separately like you do: http://i.imgur.com/BqS1iht.png

Your input format is also confusing. On your site, users have to type '6C 6D' but everywhere else on the internet, that would be written '6c6d'
Is REST context an 'official name'?
Google called it a partnership and Softcard said something along the lines of "Google is acquiring Softcard's technology" which leaves me a bit confused but I don't think it's an outright acquisition.
When people can't walk by and see your monitor you definitely rule out people walking by looking at your monitor and striking up conversation about whatever you are currently working on. It's not so much about privacy as it is about getting your work done in peace. A workplace that offered people the option to move into a more communal space when working on projects, but also offered cubicles or offices would be a solution.
He proved he wasn't clueless a few answers in the thread. But by that point that fact possibly bothered me even more. It was as if he was trying his best to be smoky and withholding information that could have proven to be relevant (hence the smartass comment I made. That's exactly the opposite of what a rep should do, i.e. trying to figure out how to help out.
We mustn't allow the clarity of truth to be muddied by facts.

What are you, an NSA puppet or something?
I work crammed into a long table at a Starbucks, and I much prefer it to the company office. Call me crazy, but I don't think office space and privacy is the most important thing to office workers.

The problem is they're stuck in an office.
Ah, the tried and true debate tactic of repeating someone's words in a high voice to make them sound funny.
I'll take a crack at this:

In college I would always prefer sit in the very back of the lecture hall, back to the wall, even though I knew that real go-getters were supposed to sit in the front. I get really startled if people walk up behind me and try to get my attention, especially if they touch me, my clothing, or my chair. I don't like to be in a space where I can't see who is coming in and out of it, for my own safety as well as to minimize jump-scares. If people coming up behind you while you're all vulnerable and absorbed in thought is something that bothers you, having to work in a space where this is a constant possibility is annoying in the same way that working around high-pitched mechanical background noises or rapidly flickering lights is annoying. It's constant low-level apprehension and stress.

When you introduce screens into the equation, as in open office, there's a new annoyance which I guess you might call "violation of intellectual personal space". Have you ever gotten really annoyed that someone was reading your book over your shoulder? Or felt antsy when someone grabbed your laptop to do an internet search? Or had a coworker glance over at your screen when you were deep in thought and say "Hey, what's that?" Computers, books, and notes can feel like extensions one's mind and it's annoying when anybody can come peruse what we're thinking. My monitor is my mind-workspace. I'm happy to have visitors, but not at any old time they feel like strolling through the door!

I'm not saying that YOU think this, but your comment brought it to mind: Some people think that by making it so that anyone can see your screen, you're less likely to goof off. (With the logical follow-up: Anyone who wants their back to the wall at work just wants to goof off.) Neither is true, in my anecdotal experience. People in open offices will still goof off, they'll just be more sneaky about it. (Or, there will be a complete breakdown in focus and professionalism, and everyone will goof off in a completely brazen manner.)
> Considering how cheap office space is compared to labor,

Unfortunately the finance department is great at showing the opposite.
Open offices are cheaper (more people per sq ft) but all office space prices have skyrocketed in the "tech hubs" in the last decade or so.
Excellent! Because I would hate to pay a nominal sum to people risking their liberty, and perhaps even their very lives, to spread the word about government abuses that threaten the future of not merely the 300-plus million people living in this country but people from around the world, too. Can we get more of this?
Ask HN: Lawyer for closing startup fundraising?
Can someone recommend a lawyer that is familiar with YCombinator's standard SAFE agreements and can walk a startup through some of the legality of it and the process that goes along with it?
I'm just saying, if you simply used these results to guide your bidding process, any halfway-decent player would take all your money.
I think at this point we are getting into the semantics of what qualifies as a "vulnerability." I agree there's very little telegram can do about this, but that doesn't lessen the validity of the attack. At the very least, they could respond to the bug report. To ignore it seems highly unprofessional.
There is. Lately, a lot of the top companies sponsoring for visa are getting in trouble because of fraud[1].

http://www.wsj.com/articles/SB100014240527023045275045791674...
Alternatively, you could look at what % raise a former H1-b visa holder receives when he gets his greencard.

I heard it can be 2x-3x, but I've never seen a formal analysis.
because it's a natural instinct, your "nothing to hide" type argument can't trump thousands of years of evolution
I think a wise person would hesitate at judging a task hard or easy.
I really like the workflow chart on slide 22. I can't help but think this is a useful way to visualize common workflow sequences of commands (think git add, git commit, git push).

Honestly I wouldn't mind if man pages came with ascii art to visualize this type of documentation.
I blame blissful ignorance: I'm not at all familiar with DPDK. I'll definitely read up, though!

I wonder if O_DIRECT writes can happen from DPDK memory space? If not, we don't gain anything, since we'd need to copy packets into RAM for writes anyway.

Supporting stock Linux is definitely a nice-to-have... I'd like to make this a relatively easily installed deb. Currently, all dependencies are available via apt-get in stock Ubuntu.
Isn't there an EMV-NFC standard that eliminates the need for POS integration? IIRC CurrentC was the one that isn't using the standard.
I just did this on my new Zenbook and it was extremely easy install.

Though I was installing from an MSDN install DVD which isn't something everybody would have on hand.
It's official: billion-dollar startups are boring
Twitter users agree: Gmail’s new autocomplete algorithm is an epic fail
> it is a different discussion.

This isn't a discussion about how far "pure weed" can get you, it's about what's going to happen now that the laws don't deter people from applying technology and science to weed, and whether a 'fatal dose' is just a limitation of the literally stone-age techniques we currently use to consume stone-age quantities of weed in its basic plant form.
Actually, this isn't the day and age where native code IDE can be presented to be advantageous. I think what's sensible is to assume that no thick-client IDE is sufficient for arbitrarily sized projects.
I totally understand you. Names are important to me and it helps me a lot when I have a perfect name to go with what I'm doing. I can't explain or rationalise it. It's just the way it is...
Ask HN: Could the answer to carpal tunnel syndrome be the trackpoint?
I used to get small pains in my wrist, hands and forearm when working on a laptop. I tried changing my posture. I tried using external keyboards, external mice, touchpad only, on both PC and Mac laptops. The pains were still there. I was lucky in that I didn't have to see a doctor but I know people who have had to wear special gloves and have treatment

Since I started using a trackpoint (on a Thinkpad) and setting up the OS to completely disable the touchpad, the pains have gone away and have not returned. Funnily, my posture is still bad, hunched over the laptop like most people, but my pains are gone.

My theory is that not having to constantly move my hand down to the touchpad to scroll, or move down to click a button below the touchpad (or press directly on it like Apple touchpads) has meant that I avoid lots of small movements. These micro-movements probably caused stress, as does using an external mouse and having to move my hand off the keyboard, onto the mouse, move it etc.

Just wondering if anybody else has experienced the same thing?!
Interesting to note the "developer" position salary in Illinois is slowly getting lower year by year.
Periods of low atmospheric pressure correlate with high aneurysm rupture rates
What Happened with Lego: The price of a brick
Stoners driver safer than most sober people, your opinion is ill informed and based on alcohol, which is a vastly different drug.
Who told you?

I work in nether finance, nor on the Wallet team, so I don't have information about the details of Wallet's workings.

Regardless, it's proper for the claimant to provide data to support their claim. :)
Smaller and Smaller (2012)
Private ~~study~~ work carrels anyone?
So you want your user data chached and accessible by others?
P2P music-on-demand streaming slides (2010)
15 minutes to create your WordPress website without coding
will the alpha version pricing still be available at that time?
Dell is about the only manufacturer that will let you get generic install DVDs. They use a bios based licensing system these days so you don't even have to deal with those issues so much.

http://en.wikipedia.org/wiki/System_Locked_Pre-installation
Long tables would have given each person even less space, he said — about 2 feet wide by 1 ½ feet deep.

Seriously? 2 feet is elbow-bumping width. Is this moron planning office space, or seating for fucking RyanAir?
Vaporization.
> Unfortunately there isn't a very reliable test to see if someone is under the influence of anything other than alcohol.

I heard a lot of noise almost a decade ago about impairment testing. The idea is not to test for a specific drug, or a specific amount of a drug, but rather to test the ability of the person to react to situations. There isn't a lot of material out there about it, but it was highly praised at the time (in the info I came across) because it gets closer to the question that we really want to be answered: does this person currently have the ability to safely perform the task at hand? It removes the stigma of particular substances from the equation and also gives you the ability to test someone who is "drug-free" but also stayed up all night and may not be as able a driver (or machinist, or nurse) as usual.

That was all a while ago, and I have yet to hear more or read any in-depth studies about the practice. Does anyone know if new research has been done?
I also think that the way the DisneyCollector sound is recorded plays a role. It sounds a lot like binaural audio - http://www.theverge.com/2015/2/12/8021733/3d-audio-3dio-bina...
I have known plenty of developers who may be great at coding a task but fall flat when architecting the same systems. There are often tradeoffs that must be made for business or technology purposes. These tradeoffs are generally product or engineering decisions that i would hesitate having a developer make.

There are just functional differences between developing software and engineering it. The sooner the software industry recognizes these differences, the better served we will all be.
Finally, proof that the Kool-Aid man could actually break through a wall
Really? Did Einstein have empirical proof of his ideas?
You might be surprised to hear that 95% of poker players do not consider JT mediocre.

(I'm not among the 95%!)
I'm sure it isn't that hard for somebody to get their hands on the private keys for those products and I bet they used the same password.

Edit: LOL, ok so the keys are right there on that link. Nice!
LCA declarations filed for H1B does have salary data. It is there to stop people from exploiting immigrant workers. At least that is the official stance.
I am not sure how accurate the numbers are but this site seems to have extracted info from the H1B applications:
http://redbus2us.com/h1b-visa-sponsors/
searchable by city.
Looking up menlo park tells me, FB was the largest sponsor with median salary of 133k.
A coworker and I made this today in a little over an hour after realizing we didn't really want a full-blown prototyping site a la jsfiddle. What we wanted instead was just a quick page we could load up with several popular libraries already in scope, so we could minimize our time to hacking.

We're very interested in hearing critiques of the page or opinions on what else you'd like to see there!
Do you have source to backup this claim ? I found it quite doubtful.
They're looking into Linux servers that try to emulate their services because we do a hell of a lot of interop work together, to make sure all consumer devices and networks 'just work'.

And I'm very grateful for it !
To be fair, to my knowledge, LASTZ, BLAST, or BLAT don't treat IUPAC ambiguous bases (K, Y, R, etc.) in the way the OP was looking for. That's not to blame the tools, since they have a very good reason not to (they build an index on the target first, and treating ambiguous bases properly would increase the size of the index).

That said, I wonder if grep wouldn't be much faster, since this program is only looking for exact matches, which are easily transformed into a regex by replacing the ambiguous nucleotides with something like (A|T|C).
hmm, interesting, i always just use the silent switch on the side of my phone. perhaps we should add a setting for that. thanks
Same here, I know someone very smart and prolific and I've sat next to him and watched him code page after page smoking bowl after bowl for almost a year. That's what makes me think it's all about the person and nothing to do with the substance.
How did he still have people working for him? I imagine that kind of bullshit would make most of the team walk out.
Hi @dennisgorelik!

“How many hours typical developer on your remote team work on?”

A week? 25-40, depending on the urgency in the project at hand.

“What is the typical hourly (or daily or weekly) rate for senior developer who is working on the same project full time for months or years?”

Our standard rate is €1k/day. Larger projects are negotiated on a case by case basis.
How was the identity of a telegram's sender proved? (2014)
you have a sense of privacy in public, a lot more than in a space with a set group of people that you have to constantly interact with. in a cafe nobody cares how "busy" you look, you're just getting stuff done, in an office it quickly becomes about appearances, or leaving only after your boss left even if you're no longer productive, etc. basically in a public space people can "judge" what you're doing but it doesn't matter while in a private space people "judge" you and it matters.
"But it's probably a submarine article planted by the architecture firm anyway."

Agree, and to those who don't know that means see this[1]:

http://www.paulgraham.com/submarine.html

[1] It's PG's phrase not a common reference.
FYI: the visualization doesn't load if you're using adblock or uBlock.
You should read about H1B transfers.
Sorry, dumb question: why is this on HN today? Was there some major change in a recent release? Or is it just that the OP just discovered it?

I have no objection to either reason; I just want to make sure I didn't miss it if there were a major update that added new functionality.
Ireland doesn't that many forests, but it is more like 10% (http://en.wikipedia.org/wiki/List_of_countries_by_forest_are..., http://www.thejournal.ie/ireland-forest-area-577152-Aug2012/).

That percentage is going up (http://www.foresteurope.org/documentos/State_of_Europes_Fore..., figure 5 on page 21; nice map of Europe on page 6, by the way)
That doesn't help with the first part, about a phase vortex in compressible inviscous liquids.
This is mostly untrue, to my understanding.

It was not solved to maximally exploit a bad villain, but it was solved to be unexploitable, and therefore unbeatable.

It would make mountains of chips vs 99%+ of players, probably at 80%+ of the possible rate.
Reducing Testing Time and Blaming Testers
Thanks guys, appreciate the responses.
Yep, if we were to say that in kernel struct changes mean a major release in semantic versioning, there would never be anything but major releases.

Even though for all of them the user space api wouldn't break. So yeah, I think the people harping on semantic versioning don't quite understand the reason its not a good fit for an os kernel.
Completely agree, this is the way my office is currently setup while they're building additional space for developers and it drives me insane. This PHP CEO tweet describes my situation pretty dead on: https://twitter.com/PHP_CEO/status/549719518420152321
You can get a screen shield that reduces viewing angles for that kind of stuff. That's what we do for HR/accounting staff who are in open areas.
Do you have any info on the hardware incompatibility ?. I always assumed that mobile payments were meant to work with those existing NFC POS terminals.
Thank you! That changed my mind.
At least in our limited experience we aren't saving any money, and that's not the driving factor. When the best person for the job needs a visa, that's what we do. It typically costs us $5k+/year in filing and legal fees on top of salary actually, so we pay MORE for H1B employees.
Defend Innovation: How to Fix Our Broken Patent System
You're basically saying that your productivity is more important than someone else's productivity.
When I worked as a dev I hated having people walking around behind me. I worked at a place where my desk was near a relatively high traffic area so there was a constant stream of people walking past.

I find it hard to really concentrate on something with random people walking around or hanging out behind me. It has nothing to do with them looking at my screen even - just knowing someone is standing around behind me can be a little unnerving. I'd much prefer having them in front of me than behind me.

It almost feels like a primal survival instinct. When you're concentrating on work you're more vulnerable because you're less aware of your surroundings. It's not like I'm really expecting to be attacked from behind or anything but something deep in my brain is sending up an alarm.
Snowden, Poitras, Greenwarld: Reddit AMA
"The best city for software managers was Vancouver with an average salary of $183,500"

Is it because it's in Canadian dollars?