skysight-inc/HackerNews huggingface dataset:
Here's the piece of the picture that everyone's missing from this particular example - an $11b acquisition [1]. Gilead bought Pharmasset for $11b. It no longer matters what it cost Pharmasset to research/test/approve/produce the medicine anymore. Certainly all of that was factored into the acquisition price but since Gilead's total cost ended up being $11b, that is what they need to recoup at the least.

There are 3.2 million hep C patients in the US [2] but most don't feel ill or even know they have hep C. If every single person buys the drug, Gilead must still sell it for at least $11b / 3.2m = $3500/person! But if only 5% buy the drug, they need to sell it for $69,000 just to break event on the acquisition without even taking any other costs into account.

This is just rough calculation to highlight that a sky high acquisition price resulted in a company demanding an equally high price per dose. Gilead paid the high price to acquire Pharmasset because they thought they could sell the drug for at such a high price per dose. If Gilead is proven right (and their stock price from $18 in 2011 to $100 in 2015 seems to reflect that indeed), then this just encourages more and more drug companies to be bought at astronomical prices.

And the worst part of this is that the very government that gave this company the right to operate a monopoly via a patent is now asking them why they're charging so much [3]. None of this happened because of some singular evil cabal. It happened due to misaligned incentives.

Government grants pay researchers, who develop medicines at paid-for-by-public-funds university labs, which sell the patents back to the researchers at fire-sale prices, who then go on to create biotech startups, which productize the research, and then sell to Fortune 100 pharmas, who can then demand almost any amount of money, which CMS will have to pay because USPTO said nobody else can sell this drug, FDA agreed that the drug works, and ACA ensures that the patients cannot be denied any drugs that work at any cost.

[1] http://en.wikipedia.org/wiki/Pharmasset
[2] http://www.hhs.gov/opa/reproductive-health/stis/hepatitis-c/
[3] http://www.finance.senate.gov/imo/media/doc/Wyden-Grassley%2...
See the beauty of the situation is that they are all at fault. However, only one company makes the core OS software these hardware manufacturers run on.

Perhaps if Google provided the update and the pressure could be put on the manufacturers to roll out the update to their paying customers...?
Except that you already have cameras pointed at you 100% of the time.

If people are this uncomfortable about Google Glass, they had better start tuning in on the implications of everybody uploading selfies and videos on Facebook, YouTube, etc.
Doomed is worse than less useful!
I expect that using a screen reader and a blindfold would take some considerable time to get effective at, even for accessible sites.

As for the sites I am responsible for, I try to make them accessible by reading and applying the guidelines, but I do appreciate feedback from blind people on ways to improve it for them.
I'm going to presume this is sarcasm because that is literally exactly what they did.
The swiss have effectively left the eurozone
Maybe one must be made ...
Nintendo handle backward compatibility since the snes by embedding the cpu of the previous console in the new one. gba had cpu for the gbc. wii had cpu for the gc. ds has cpu from the gba...
>I suspect they don't perform code reviews.

It certainly seems that way. CSGO (their FPS) is notorious for updates that break things, like very recently a gun having less ammo than it should, or masks (halloween thing, I think) being rendered through smoke (a crucial feature of the game).
amazing how mountable and wearable camera is ok with gopro and other similar solution but not ok with google glass...

I believe its not camera but elite and exclusiveness it created got backfired... (though typically it has worked well for other products launches like gmail etc.)

also 1500$ tag is bit over priced for a tech gadget..

Nash, http://joday.com
i thought I'd never live to see devkitpro people (assuming the author of that site is affiliated) promoting a closed source emulator.
Whenever I write something scary like that, I usually wrap it in a function, double checking if it's really the folder you wish to delete ... Often even adding a user-verification if possible.
Although if you think about it, a lot of people obsess over tiny little things just to please:

* parents
* love interest
* fashion
* social group

In a sense we all do it all the time. "Gaming the system" and what have you.
Well I'm on the guy's side but this worth noting:

Including my 3tb external drive I back everything up to that was mounted under /media.

Well maybe it was just unfortunate and the drive just happened to be mounted or the "backup" is always online. If it is the latter it is a really bad idea. If your computer is compromised you risk all of your backup. A proper backup should protect your data from these occasions.
I'm not blind, but my father had low vision and so I know a little about the experience. It infuriates me that authors have pressured Amazon into removing the audio text reading ability of the Kindle. Such small-minded greed is indefensible.
Hogwash. The number of times I see people actively aiming their lens at me is quite small despite the large number of smartphones and the like around me everyday.

If you can't determine the difference in social expectation from a watch that is literally pointed all the time vs your occasional "selfie" -- well, keep guessing as to why others were pissed to feel "potentially" recorded without consent.
Yeah the rich are still raking it in, while the average and low income people are not. I.e. the vast majority of people.

http://www.counterpunch.org/2015/01/15/40-years-of-economic-...
> @jasonwocky The snippets you highlighted do seem a bit like a "get-off-my-lawn" reaction from the author. SPA architectures certainly have their places, and it does feel like the author hasn't had experience w/ building heavily dynamic UI apps.

> The snippets you highlighted do seem a bit like a "get-off-my-lawn" reaction from the author.

New and shiny ways are not always the best. I'm still not seeing people writing kernels and device drivers in JavaScript.

> SPA architectures certainly have their places

And what areas those might be and why?

You can build heavily dynamic apps without trying to do everything in the browser.

Problem with the web nowadays is that a lot of decisions are being made for political reasons rather UX considerations. SPA architectures are appealing to front-end developers who just can't be bothered to learn how to do routing and templating on the backend or they just want to have those things in their territory.

For me UX matters more than shiny architecture. I did the experiment in Chrome where I had HTML and applied some stylings to it via the raw DOM API as soon as possible. There was a noticeable delay before the stylings got applied and this was the highly optimized DOM code with no Angular, no jQuery, no nothing. The moral of the story is: browsers are still faster at displaying HTML and CSS.

Aside from the performance failures, Angular has huge problems when it comes to writing maintainable Angular code like the scope hell, but you can find many others here: http://ihateangular.com/
Law enforcement revealing true exculpatory information during cross-examination isn't screwing up -- like all witnesses, their duty is to tell the truth. (Its true that some of them may view their job as getting a conviction, and may view providing the truth as screwing up when it is contrary to that, but its a very bad idea to reinforce that meme.)
What? I've used Glass, there is no "record light". It is perfectly possible, without hacks or nefarious programming, to take pictures and record video without any outward indication of activity.

Savvy people could try to spot Glass being used by looking for the subtle glow when the HUD screen turns on, but that's a very far cry from an actual "activity light".
I think the point is that once we hve DNSSEC, we have no way around. With the CA system there is lots of room to improve on it, without more centralisation.

Im not a expert but thats my take so far.
The 'lipstick killer' case may very well have been a gross miscarriage of justice. It's a long read: http://en.wikipedia.org/wiki/William_Heirens
"Technology made it obsolete to shadow suspects on foot (Hammett’s specialty) and by car, with satellite imagery making it possible to see a case to completion from the privacy of a cubicle."

What sort of cases would be solved using satellite imagery?
> Smart glasses with no way to get visual input from the environment would be a much less useful product.

The only real use for Glass was a HUD + low quality camera, considering the positioning of the actual display. You don't need a camera for a HUD. Now if Glass went after augmented reality, then I'd totally agree with you.
I moved languages to a subdomain instead of query strings as suggested by a Google website, and my rankings plummeted.
How to Spy on Text Messages Online?
You too can collect big data! (about ESM/PACO at Google)
I agree. I imagine I could learn quite a bit just from sitting behind a Google/Facebook engineer for a few hours.
It's amazing that there were able to catch the needle in the storm.
Author Interview: Lance Dodes, Author of 'The Sober Truth' (2014)
I didn't realise that. Couldn't they have turned it into a laser? That way they could still queer their pitch by reminding people of the Borg, but at least I'd have a range-finder and look cool at discos or something.
12 Amazing Tips for Choosing a Cell Phone Spying Software
The iPhone has VoiceOver, and there are bluetooth Braille keyboards/displays for typing.

This page goes into a bit more detail: https://andreashead.wikispaces.com/How+Do+Blind+People+Use+a...
Me. I wanted something with a video heads-up like display (maybe with sound likely preferring BT/headphones). A radio, processor, memory, maybe a little storage ... but no camera.

Without the camera, the audio portion of the handsfree UI would be front and center - contextual visual updates based on geolocation, speech commands, you name it.

They tried too hard and didn't make a focused MVP, just a mess of stuff that might be cool.
>> Second-guess whether he was really using the glasses or just filming the woman.

I can't help but ask: so what? I know I might be totally biased here as I never had an issue with being filmed, but such examples make me feel we're trying to blame technology for what is our society having trouble with its own sexuality.

I accept this is an issue, though I personally don't "feel it".

> There's also the aspect that may of us already spend 50-75% of our lives looking at screens. Most people know 'that guy' who can't go out for breakfast without checking his feeds between bites of huevos ranchero. IMO, "it make anti-social activities even easier" was never a very good sell (perhaps outside the googleplex.)

Now this attitude, very common among people, is IMO unfair and feels like bullying. I am 'that guy'. And you know why I'm sticked to some screen for most of the day? Because brain-computer interfaces are not here yet. I'd be happy to use some different interface like, say, AR glasses but hey, aren't those being frowned upon because they have a camera? sigh.
Nearly everywhere in public (at least in a decent-sized city) you are highly likely to be captured on CCTV.
Maybe it meant smaller companies paid less, too.

But if the employees were truly worth more – they produced more in value – then as long as new companies were free to start (some indeed started by those same ex-cartel employees themselves), then someone would pay that full value.

And if, with hundreds or thousands of potential employers, almost all outside the cartel, the salaries were still what they were... then what's the proof employees were worth more, anyway?

If there's some purchasable commodity that can generate $X in value, then a competitive market will tend to offer up to ($X - epsilon) for that commodity. Even if a cartel of a few of the biggest purchasers A, B, and C coordinate such that they'll only pay (0.90 * $X), the existence of dozens or hundreds or even thousands of other self-motivated bidders mean the commodity is still going to go for ($X - epsilon).

The same goes for skilled labor. The A, B, and C cartel may be driving down their short-term compensation costs a little, but by incrementally letting talent that's more productive go elsewhere, that talent and the economy is still doing just fine.
Who wears a gopro in bars and restaurants??

Is it really amazing?
Like most professions, I am sure there are doctors who are like you describe as well as many others at they opposite end of the spectrum. Its wrong to generalize them all to be like this.
> Another pain point is that we have a certain space where text needs to be displayed and everything is fitted using English but after translating to other languages, some strings are much longer than the allotted space.

As a rule of thumb, if you're using English strings to design your UI, you should account for 30% more space so other languages can fit in. Of course, sometimes this might not be enough.
Lace Wedding Dresses
Obama's War on Hackers Creates Cyber Police State
> DNSSEC is Expensive To Adopt/Deploy

I live in .cz domain and almost every registrar there have DNSSEC in one click (without changing price) - adoption here is 40%! - see https://stats.nic.cz/stats/domains_by_dnssec/ and I am not experiencing any mentioned problems at all

Maybe DNSSEC is not best DNS proto in the world, but these arguments are not entirely based on facts.
Elon Musk releases first dramatic pictures of failed Falcon 9 landing
Agreed. The camera never had any truly compelling use case - even the most basic one, taking a picture, was not actually a UX improvement over taking out your phone and doing it, especially considering the leaps and bounds by which phone camera (both hardware software) has improved.

There were some cool tech demos that exploited the camera rather impressively - facial recognition for one, but all of these are technological curiosities rather than mass-market useful. There was never a use case that seemed relevant to the everyday user where the camera was really all that useful.

I do think the camera contributed substantially to the failure of the product. More than the existence of the camera was how it was handled - no record/activity light as has been customary on many such devices, and the design of it felt viscerally like a hidden camera.

Which isn't to say Google intended to create a hidden camera, but in trying to make it blend and look like normal glasses it made the camera seem less upfront, more dishonest, and more intrusive than, say, a guy who is literally wearing a camera on his head.
> …it is terribly weak in that there is no logic for defaulting anything other than to zero.

That is the weakness I addressed. IE, it may seem terribly weak up front, but in practice it's really not a weakness at all.

And, if zero is the default, then it doesn't matter if someone explicitly requested the default, or got the default by omission… It's like using 'exists' in Perl. It seems like it may be important to tell the difference between 'existing as undef' vs. not existing at all, but in practice it's just not needed (I can count the times I've legitimately used 'exists' during my almost 20 years of Perl programs on just a couple fingers).
Not just Haskell.
Yes, the camera isn't socially acceptable. But glasses are. So they could've had a HUD that only responded to location- and audio-based cues - map with directions, walking tour, alerts that people would otherwise look down at their phone (or smartwatch) for, etc.

They could've made that work and avoided the stigma they ended up facing, until adding a camera was more reasonable.

Would that featureset have been that useful? Maybe not, but then was the Google Glass we got that useful? Didn't seem so.
> unsafePerformIO :: IO a -> a on the other hand does make haskell impure when it is used. And it is used in many libraries.

Hmm, does it really? Is 'unsafePerformIO (return 1)' impure?
> When you are walking down the street you don't need to read status updates because you don't need to be distracted (most of the time).

Don't you? That's exactly when I pick up my phone; unless I have something to think through, walking to/back from work, etc. feels like a waste of time for me so I do want to do something then (read, reply to emails), or at least distract myself with social media.
Paul Graham once wrote an article on the curse of implementing an idea when you had enough money: http://www.paulgraham.com/segway.html
http://handmadehero.org/ is a currently active series where an experienced professional game developer is simultaneously coding and explaining the creation of an entire commercial game completely from scratch (without the use of middleware or libraries beyond OS vendor standard libs). The explanation is aimed at beginners and is very nicely delivered. https://www.youtube.com/user/handmadeheroarchive
Well I'm sure that plain DNS look up responses are faster but I have been tought that that the difference between O(1) and O(log N) is really just theoretical and in practice the constant factor is typically more important. log N grows really slowly in the function of N.
Interesting article. Nice analysis and formalization of two thought frameworks (Thiel and Graham). Good ideas and good research with the mix of anthropology and psychological included.

Framing this whole article as a hypothesis, the question is now whether this hypothesis can be proven (ie does it work in real life) and what are the limitations of this theoretical approach (ie maybe it will work only for software and IT opportunities).

Anyway it seems like an interesting avenue to explore (combining psychological and anthropological studies with investment research). Does anybody know of any VC/accelerators/incubators that apply this method?
The choice is between definitely getting fired and maybe someone's data getting deleted.
> They did grasshopper landing without them right?

As someone who doesn't know the slightest bit about space technology, I was a bit confused about the fact that they successfully landed another rocket. If that's the case why is the landing of Flacon 9 so significant? Is it like a bigger rocket or something?
The smartphone requires awkwardly peering at a glass rectangle, yet it effortlessly reorganized social norms, because it's so damn useful and interesting. So why didn't Glass do the same thing?

> I found that it was not very useful for very much

That's it. That's the real issue, not the camera.
It's worse. It's monopoly money.
What would you be interested in seeing? I can't make any screen casts of work projects but I can do them for personal stuff.
Which is why the cases in which the police harm or injure people should be brought before the court. Not decided by a prosecutor or grand jury, those entities shouldn't be deciding what is lawful.
Here, let me burn the exceptionally modest amount of karma I have on HN.

I am married to an immigrant. Immigrants have been huge contributors to the country. We should keep 'em coming. I'm pretty sure virtually all "anti-immigrants" agree.

But what many call "anti-immigrant" is propaganda, due to deliberate and willful devaluation of the term "immigrant". It has come to supplant the more accurate terms "illegal alien" or the more modern "illegal immigrant".

We spent years navigating the hideous INS bureaucracy to obtain her citizenship. Amnesty bills are a slap in the face to those of us who played by the rules. The fact that existing immigration laws go largely unenforced have resulted in depressed wages and large swathes of the Texas and Arizona borders becoming killing grounds and defacto "no go zones". Farmers' lands on the border are becoming unusable and dangerous. Illegal immigrants place enormous burdens on hospitals in border states.

Like many on the right, I am strongly for legal immigration on pretty generous terms. I am strongly anti-illegal immigrant, and not the least bit "anti-immigrant". I do want to see existing laws enforced.
Visionary Domain Expertise
Tough Days for Microsoft’s Skype Translator Ahead?
Honeyshare
Very interesting read. What I would add to this framework is the often overlooked "solving one big problem" vs "solving lots of small problems". Most startups try to solve lots of problems, which can be seen by the number of features being developped. This is understandable: in the early days, you keep thinking that "if we had feature X, we would close customer A" and keep on adding more and more features.

In general this doesn't work, because small problems are something we can live with. It's way better to solve one big problem, the one the customer is losing sleep over.

At Local Motion, we noticed that the big customers we closed fast were always companies with one very big problem we could solve (e.g. "my cars are getting stolen") vs lots of small problems (e.g. "software tool for maintenance" + "data reports" + "graphs" + xxx)
One of the early big interviews about Glass featured Brin or Page (not exactly sure who of the two) telling that Glass is for taking POV pictures. And he talked about nothing else. While all tech guys (like me) where dreaming about augmented reality, or even just having some Android apps of choice in my view all the time while being able to walk around, all he focused on (and everyone since) was taking pictures. So it was intentional to not look past the camera I guess.
> That's easy to fix, although it means some weight penalty.

It's probable that they use RP-1 as the hydraulic fuel and then dump it after use into the main RP-1 tank. In this case, assuming they don't need more high-pressure fluid than they need braking fuel, there is no weight penalty.
3 Tools for Recovering Your iPhone Data
Well I'm a bit late on the questions but here is my suggestion:

For the really secure wallet you program two (or more) cards with the same key in case one of them is lost or craps itself (then throw away the private key). They are protected by a PIN code so they brick themselves after 3 subsequent wrong tries. If you lose one of the cards then you get two new cards, program them with identical private keys (clearly it is different than the previous one) then transfer all of your money to the new wallet.

It's really hard to be your own bank, but it is possible. The beauty of bitcoin that you don't have to trust any third party, but it's really hard manage properly.

I would be surprised if anybody used this scheme, I don't have any bitcoins either. If I jump into the bitcoin business I'm sure I will adopt this scheme.
Tough competition between two giants. Loss for small app making companies. Win - win situation for tourists.
Soup to nuts deployment issues. When to use Docker. What to monitor, when. What logs to look at. How to balance security against convenience. How to use Fabric to deploy a Python app. How to completely script server deployment of web apps. How to turn a toy database-backed app written in Python into production code, and exactly what shims, insecure development features, etc. should be removed.
Chase Stash Launches World's First Retail Pawnshop for Exclusive Sneakers
zsh has a nice feature where rm is only interactive if you are deleting everything in a folder. Another safety feature I really like in zsh is to tab-expand wildcards, so I can check that it's not deleting anything it shouldn't.
Perfect SEO Profile
Interesting read! Thanks.