skysight-inc/HackerNews huggingface dataset:
There are a few non-hallucinogenic and non-sedative derivatives of ketamine being studied at the moment as antidepressants. Anecdotes of their use seem to be positive, but of course those should be taken with a grain of salt. See LongeCity's Brain Health forum for some crazy threads relating to this.[0]

On another note, this summer I experimented with NSI-189[1] for depression to great effect. It's a hippocampal neurogenic agent currently prepping for phase 2 trials. I found that its antidepressant effects over a one-month cycle were remarkably similar to my single psilocybin experience a few years back. Specifically, they both (or rather, I) exhibited two characteristics:

(a) "Illuminating" rather than the "dulling" of traditional antidepressants. A feeling of irrational filters being lifted from all my senses and the cognitive functions directly adjacent to them. It doesn't feel like a band-aid like tricyclics and SSRIs do. It feels like a realization that the depression is a lie, that it doesn't reflect the actual state of the world.

(b) Persistence of the effect long after the chemical was no longer in my system. Where "long" was approximately two years for the psilocybin, and I'm coming up on four months after cessation of the NSI-189 with not just steady benefits but continuous improvement. This matches the results found in the Phase 1b trial.[2]

Now I haven't gotten an MRI to see if my hippocampus has grown to an abnormal size, like was found in an early mouse study, but my experience has made me extremely optimistic for the next ten years of antidepressant research. I'm fairly certain we'll be able to narrow down the exact mechanisms by which psychedelics alleviate depression and isolate them from the permanent destructive potential of most psychedelics.[3]

[0] http://www.longecity.org/forum/forum/169-brain-health/

[1] It is currently not being sold, and its patent-holder Neuralstem is being quite threatening toward would-be vendors. There is nothing illegal about purchasing it, but it would be difficult for anyone in the US without indirect access to a quality Asian synth lab and a domestic third party testing facility.

[2] http://smithonstocks.com/neuralstem-phase-1b-results-for-nsi...

[3] I should mention that though I'm comparing NSI-189 to traditional psychedelics in this comment, it doesn't actually have any major immediate effects. Common anecdotal effects include heightened taste and smell, back-of-skull pressure/ache and mild parasthesia. A couple instances of major, painful parasthesia in individuals with previous nerve damage. But no headspace, no high, no rush, no immediate feeling that you're taking a drug at all, and the antidepressant effects do not reveal themselves for at least a week.
If you'd grown up or evolved elsewhere in the solar system, there's a high chance Earth would be inhospitable to you, just like Mars is to us. Your dream home would be Saturn, or Venus, etc.

The universe has a history of destroying the majority of life on Earth. It would be naive to think that statistics don't apply to the human race.
So your argument is that two wrongs make a right?
Really a good joke for “Every TEXT is a quine.”
> Money only matters to the extent that it buys ads that move voters. And there's only a limited amount that matters in an election. If you take a house race and outspend your opponent $10 Billion to $1 Billion, but have a worse message, you will lose.

I found this dubious, so I went googling. I felt I ought to share what I found:

http://www.benzinga.com/general/politics/14/11/5012697/why-m...
Ezra was the first to start making Redis popular, wrote the initial implementation of the Ruby client, gave the first talk I remember at lightning conf. One time I met him at EY office with his family, with the 2 months old child. At some point he started to disappear more and more, we were supposed to meet in Portland at a Redis conf and he was not able to make it. I was concerned about him every time I saw a rare tweet. I'm sorry Ezra.
That goes away and growing/shaving for a few years it never itches again. I grow because I find shaving a waste of time as do most my friends. It is a good time as in the 80s/90s you could not do this in most company settings: suit, tie and shave! Now it is fine: I did not shave then either and never wore a suit as I find both uncomfortable and it did me good: like metal guys have more chance of picking up girls at normal clubs, it is all about niche. Accidental or not.
Not disagreeing, but: Bass reflex designs are an exception to some of what you've written. They essentially use the reflected sound wave you've mentioned to increase the output in certain low frequencies, by letting it out of a specially constructed hole in that solid cabinet.
"If US had a patent law like India, they would discover many more drugs"
80%-cost is higher than any other POD service I know, that's potentially quite good.

Through my current publisher I get 70% after cost, so it depends on what their fee is (and it irritates me more that they don't specify what that fee is).

I'm also more than a little uncomfortable with the monthly fee angle, especially with it being mandatory to have your books listed on other services. I'm a firm believer in 'money should flow to the author,' and it makes your book's public availability outside of a niche site with poor discoverability contingent entirely on continually providing said site with more money. Your book now no longer pays for itself, but rather must make at least enough to cover the cost or else it vanishes from the public eye.

It's a small fee, but having been through it and seeing what the long-tail of a book can look like, it's something that can add up and be problematic in the long run, and it also hampers the service's utility for those who wish to offer their book free in digital. You can also probably bet on the likelihood it will get bigger, not smaller, over time.

This is, in small scale, why vanity publishers were awful and why everyone jumped on board with POD in the first place.
It's really bad. I'm in the triangle (NC) and I've had drivers tell me they use Google Maps from their own android as its much better (I think they use Apple Maps)
There's two camps when it comes to automotive performance - those who care only about performance as a means to an end, and those who care about the journey to performance.

For example, dual clutch automatics have been better than manual transmissions for quite awhile now in terms of shift speeds, but those of us who still enjoy the journey prefer manual shifting for the pure pleasure of being directly connected to the car.

The same holds for internal combustion engines and that quality that several thousands of explosions per second bring to the table. The almost-silent whine of an electric motor may have an amazing torque curve but it will never invoke the primal feeling of a revving V8.
Gary Kildall, for one.

Anyone subject to NSA surveillance via Skype, Hotmail, Outlook.com etc. MSFT was the first company to participate in PRISM.
Time perception, just like vision, is a construction of the brain
This argument would make every commercial competitor of free software as "evil". It would also imply that all humans should seize all commercial software development as soon as something free is available. This is obviously not true. People don't pay for things that they don't have to. Windows was much more user friendly operating system than *nix and despite of several of its shortcomings, it was fairly usable by huge swatch of non-technical people. This why people demanded it on their PC and directly or in-directly paid for it.
Just what I need. Thanks for sharing.
I see more than before but it is not that common, here in north EU at least, yet. I went to two clubs last week and I was 1 of 2-3 bearded guys which indeed aided in attracting female attention (as it always has in my experience). I do not mind if this is the peak ;)
> Because Buffett is counting on an index fund when he dies.

That's completely irrelevant. Nobody is going to get Buffet rich from index funds. After Buffet dies he won't be around to decide what to invest the money in so he picked index funds because they're a good conservative decision that will outperform most investors.

That does NOT mean that you can't do much, much better than that by, like Dave said, becoming an expert investor.
As someone with depression, personally I wouldn't recommend mushrooms to others in a similar situation. I've tried them once and it was a rather uncomfortable experience. In fact, a quote from the acticle describes my experience fairly well - "When suffering depression, people get stuck in a spiral of negative thoughts and cannot get out of it". This does tend to describe my thought process in general, but this was exacerbated on mushrooms. I had little control over my thought process, which made me anxious, which made the experience harder to deal with. Although, when considering certain personal issues at the time which would normally cause me anxiety, they did feel much less significant.

That said, I've heard many stories of people experiencing life changing epiphanies from mushroom trips as described in the article, and I am intrigued by articles like this and the science behind it. Perhaps my environment, or the specific mushrooms I tried made it worse. Also, having tried them once and come out the other end fine may make future experiences less uncomfortable - a large part of what made it difficult was a concern that my mental state would be permanently affected by the experience, and this was not the case. Still, it makes me less inclined to try them again until I'm in a better mental state.

For what it's worth, these were the variety of "magic truffles" which are legal and readily obtainable from high street stores in Amsterdam, but as far as I'm aware the active ingredient is the same psilocybin as other forms of magic mushrooms. I wasn't on any medication at the time, though I have heard of certain anti-depressants and other medication either having a negative effect, or negating the effects of mushrooms entirely.
I am in a position where I know a little of Markdown and a little of reStructuredText. Considering the little time I have and I have to learn a language I would want to learn something that is extensible. Isn't that a valid reasoning?
The paper is not perfect, but it let me question the reality of the world around me and how much was real and how much was constructed.

I find papers that challenge my ideas more enlightening than ones that reinforce them. Which obviously makes sense I guess.

The paper I linked I considered reputable enough, in a topic known to be difficult, to be of note. Every paper has issues, the trick is working out if the issues kill the paper or not.
MountainWest Rubyconf 2009, Ezra Zygmuntowicz, “Redis: Key-value Nirvana”
The recent crash at SFO was caused by mistakenly thinking the airplane was working a different way than it was actually working. The pilots thought the autothrottles were engaged when they weren't and were fixated on trying to land the plane manually; something they hadn't done in a long time.

http://en.wikipedia.org/wiki/Asiana_Airlines_Flight_214
For most people, the easiest way to become financially independent is to save aggressively.

That aside, I have always invested in a small number of individual stocks, with minimal management or effort, and only moving positions between companies slowly over time. Basically, I make bets on long-term trends that I view as technologically inevitable. I don't invest in sexy companies (though some become sexy later), I invest in companies that are undervalued relative to the technology trends. That strategy is pretty trivial but it has allowed me to beat the S&P index pretty consistently over decades (famous last words) with the money I don't have a better use for e.g. savings. In fact, the margin by which I beat the S&P has been slowly improving, which I think reflects the increasing ability of tech to move the needle on the economy.

Since this is a tech site, this would seem like a repeatable strategy that anyone could and would use. But apparently people don't. Of course, I could just be really lucky.
I really wish that other services would be like this. You enter text in a few popular markup languages and not one specific language.
Graph of SICP chapters
I'll take torque and actual performance over sound effects any day.

Also, real "journeyists", wouldn't settle for less than a v12 ;)
Rest in peace Ezra
Fire phone for $200
>Assumptions:
>– You can earn 5% investment returns after inflation during your saving years

This would maybe make sense in the 1990s or early 2000s but it's 2014!

ZIRP forever is the new normal, and judging by what happened in Japan post 1991, it's going to continue for at least two or three decades.
Merb started as essentially a wrapper on top of mongrel handler. Merb = Mongrel + erb. Mongrel had concurrency and it was super lightweight. However, it did not have goodies like routing or templating engine. Ezra write Merb as modular framework which did not care if you used datamapper or active record. Haml or ERB.
I'm glad you found it usefull!

The relationship between this sort of meditation and the various schools that use meditation as part of their doctrine seems to me be like the difference between engaging in an exercise and exercising as part of a particular club/school.

Personally I've had a few moment in my life where there introspective skills I've gained from this have probably been for the better.

Not sure if it's from the practice, or just some anxiety relieving placebo effect caused by the practice, though. Seems to be good for me, whichever the underlying effect.
You are perhaps correct. Startups are new kind of business model where you might not have to be constrained by stiff competition. You can just create something awesome and be acquired by people who then turns it in to business and fends off the competition. But then again, this doesn't support pg's thesis in its totality that no one has to be mean. People who run actual businesses in very competitive space probably have fewer options as opposed to startup founder who just want to create something interesting and sell off as one-time event.
Buy Viagra Online?
Why are you speaking of yourself using the royal pronoun?
Natural selection works fine, but relying exclusively on it might be dangerous for the human species in the longer run. Millions of species have died out because they were unable to adapt to the changing environment fast enough.

In the near future (in evolutionary timeline) in order to survive we might be forced to colonise other planets or cooperate with machines that are orders of magnitude more intelligent than we are today. We either learn how to adapt rapidly or we will be out of the evolutionary game.
I'm sorry you had a bad experience, but I like seeing this anecdote because I've seen a tonne of "this stuff (probably) works" and not enough of the other side. Psilocybin needs to be tested and studied, and I wouldn't necessarily recommend that people with depression jump on the bandwagon.
> Also notable is how far ahead of its time Voxlap and voxel objects in Blood and Shadow Warrior were.

If someone's got books, tutorials or articles on the topic of rendering voxels (the way they were used back then), I'd love some links. In the Doom community there's been talk about supporting voxel models quite a few times, and I think ZDoom now supports these, but the code is copied from build engine, which raises some licensing issues...

I'd like to see some resources to help people make clean-room implementations and just understand how and why voxel models were used back then.
Or free from NASA: http://www.nasa.gov/connect/ebooks/break_mishap_chain_detail...
It's sound, it's smell, it's feel. It's more of an experience than some number on a dial.

V12s sound good too.
"Hallmarks of Cancer: The Next Generation"
http://www.cell.com/cell/pdf/S0092-8674%2811%2900127-9.pdf
A paper that gives a nice frame of reference for understanding and talking about the biology of cancer. This paper is the follow-up of the original Hallmarks of cancer by Hanahan and Weinberg (2000).
Maybe your lack of passion isn't about the job.
My experience with Uber in Seattle hasn't been so hot, but I rarely use taxis or taxi-like services so maybe it's just the luck of the draw. One driver actively campaigned for me to start using Lyft and another decided that downtown to Ballard (as in just outside University Street tunnel station to 15th and Market) needed to go via the Fremont bridge.

It's easier for me to just take Metro and use car2Go to fill in the gaps.
I worked once on the design of the auxiliary fuel control system for a long range version of jet commercial aircraft. This single job taught me more about "Proper System Design"(tm) than my whole previous experience.
Can relate. Coding from 12-45 y.o. I've burned out a few times. Now I'm at Uni doing a degree in Supply Chain Management. I will end up with a bunch of cross discipline skills and either keep coding or not, who cares.

Do something else. If your passion nags you after a while, all good. If not, time to let go.
Wow, that manual is a lot more detailed than the popularization.

Isn't there also a flying-it-like-a-glider part after re-entry? But I guess that's a pretty small fraction of the mission.
Scientists Program Largest Swarm of Robots Ever
I'm happy that you had a sane transition from vim to emacs and it makes me honored as a programmer that you find Alchemist so useful. Thank you Chris :-)
Been doing a game with my (now) 5 year old daughter for the last year. Also uses her own hand drawn artwork, which in itself makes for interesting challenges (mostly collision detection for non tiled sprites) but she's very much the creative director to my lead developer. She loves that we can but is less interested in the how at this age
Boeing or LM? I worked for Tupolev - Tu-214D, auxiliary fuel system control module, which actually did D in the name (which means Dalnii, Long Range in Russian).

My famous takeaway from these times was
---
ARINC Report 431: No Fault Found – A Case Study
provides the final report of AMC Task Group 116 formed to
discover the causes of “No Fault Found” in avionics
equipment during test. This standard identifies sources and
provides recommendations for improvement.
---
And the BBC Micro, responsible for a generation of computer literate school children in the UK.
The thing I've always found intriguing is that the tricks used by politicians and parties to hide the sources of their campaign financing feel like they were adapted from organised crime. (Which politics may well be, but that's another matter.)

* Make sure that individual donations are small enough to avoid the source reporting

* Cycle larger donations through entities that themselves do not need to report their sources

In any other context these patterns would trigger all kinds of money laundering alarms, but in politics it's considered business as usual.
I think (this is gut - not an authority!) that Julia is very well placed for the massively parallel multi-node functional future of which you speak. lazy.jl and the cluster implementations such as spark.jl are evolving.
They definitely didn't pivot on joining YCombinator.

You can read some answers as to why Quora joined YC here: http://www.quora.com/Why-did-Quora-join-the-2014-Y-Combinato....
:D Maybe it's just me, but compared to other timepickers you don't have multiple buttons for each element(hours, minute, meridiem), which gives you a simpler design, that can look similar to your datepicker.
It's still the first draft and there are some bugs, but for now you can use your keyboard to go through the intervals faster apart from the buttons and will try to keep the same simplicity of use when perfecting it.
thanks, dunno how I missed that typo.
I want to be able to return later, but it's a bit too much to register a Facebook account (which you presumably can't do with a throwaway address?).

I'd be happy to donate more than whatever Facebook pays you for every newly registered account if you would implement a simpler method.
Former land surveyor and GPS/GIS technician here (now a developer). I have a lot of sympathy for your perspective. I remember when consumer GPS became a thing and getting a little Sheldon Cooper on folks who used "GPS" as a synonym for consumer-grade hardware: "don't you mean GPS navigation?"

But that train left the station a long time ago, and I've stopped arguing with people about it because it's a losing battle. Every normal I know, from my parents to my network of friends, refers to Garmin and TomTom auto units as "GPS." They have unfortunately become identified in the common mind with the technology.
I have also seen the GPS estimates degrade over time -- which begs the question: shouldn't those estimate be improving over time, unless something shady is going on?
Having time and mind for saving is an excellent place to be. There are no guarantees with these things. As you say the only sure thing is that inflation will destroy significant portion of your savings in only few decades. If you think things in timespans of several years you really should look into investing. This way you don't sit on your money but buy something that generates value and thus will be valuable also in future.

Spread your investment over long time and wide range of different assets and you are as safe as you are going to get.

Usually people suggest passive index funds with low fees to do this in practice. Don't take their word for it but study yourself.
The Romans did - be the most powerful nation. We often see America compared to them, not as a bad thing, but as a good thing that might fail someday. The cruelty of the Roman circus is seen as a curiosity now, even appearing in children's books, but various Nazi atrocities still aren't. Suffocating Jews somehow isn't funny yet, but releasing hungry lions on slaves is.
Set and setting bro
This probably depends on where you live? I use Google Maps and when I was living in California it was completely awesome. However, having moved to Seattle recently, it definitely is not as reliable as it used to be. This might have to do with the roads here being much more complicated though.
Convertible Notes Calculator
Ancient Computer Even More Ancient Than We Thought
Could you share your opinion on why do you think pay is lower? I would have expected otherwise, being a highly specialized and such critical niche.
How is this too much? FB reg is the simplest way possible online to create an account anywhere.
Dubai Shatters Solar Price Records Worldwide
That does not mean one can't protest it ;). You need a way to refer to an actual lousy GPS as well (long fix time, inaccurate). Lumping everything together makes it hard to be precise (like using 'begging the question' wrongly somewhere else in these comments ;)).
Does Uber use Apple Maps for its drivers? I would assume so, if they are on iOS. That could certainly explain why several comments in this thread mention Uber's direction finding services getting worse. My rather subjective experience with Apple Maps is that they haven't caught up with Google yet.
Thanks :) I did find Kite for Chrome too, it's just finding out how to edit the DOM as text and that'd give me everything I need. Will check this out too, thank you!
Frustrating to realize that perhaps only 1 or 2 years of Earth's military spending would enable mankind to achieve this (approx $1700 billion/year). Not saying we don't need to spend money on defense, merely taking one the world's expenditures as a yardstick. It would be so great if mankind is able to cooperate in the colonization of our solar system.
For serious treatment, the drug should be taken as part of a psychological therapy - in the right setting, with the right preparation and assistance. As a matter of fact, the author is advocating to make medical research easier, not that people take it at random and hope for a miracle ;)
Github can render asciidoc. Do they use asciidoctor.JS?

I found the lib was rather big :/
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