skysight-inc/HackerNews huggingface dataset:
That's the difficulty with animal studies. There are general rules that can be used to guide interpretation of results, but every drug is unique and there are a lot of exceptions to any rule.

And that's ignoring individual variation in response.

It shouldn't surprise anyone that so many drugs in development fail.
"Type in comfort"... and then ... "11.7 Inches"

Those 2 things can't happen at the same time.
This is just barely an internet startup - it's actually a real, physical business doing physical things aided by technology. I wish them luck and hope they make it to Chicago.

Treat your couriers well and I'll never have to hate you:)
All I know of it is from the article, but it seems to be a separate product, one that uses the Samsung Note 4 entirely for display and sensors. It is more like a really fancy version of the Google Cardboard VR (and one that only fits a Note 4) than a Rift, AFAICT.

I assume whatever Oculus helped with was mostly to do with software and/or helping Samsung spec out the sensors used in the phone to give a decent VR experience.
I cannot leave your comment unanswered, and do not think I can convince you otherwise without baring more than I probably should.

While in high school, my mother finally left my father, taking my sister and me with her. Shortly afterward, she was incapacitated by cancer. My father would not have me back.

I continued to attend high school in spite of my homelessness. I was able to get a job at a restaurant that was a little lax on following labor law, and, initially, what I ate on the job was most of my meals (it was not allowed). I closed, so had keys to the building, and would come extra early and bathe in the dish washing sinks before the prep cooks arrived, then off to school.

I could never have afforded an electronic toy, and especially not the service plan that would come with it. And, no, minors do not get public assistance, if silly enough to try they will end up in foster care which more often than not means someone who wants the child simply to receive the monthly allowance for his "care". Even homeless shelters must turn away unaccompanied minors who come to their doors.

Eventually, I attended a good public university, but it was a long road. I do not want any longer, but I went hungry plenty-- I was 6 foot tall and 130lbs with as broad a build as you are likely to find, yet a rail.
I've owned 4 (!) different TI graphing calculators throughout the years. I believe it started with the TI-85 in the mid-90s, followed by the 86, then the 92, and finally culminating with the TI-89 in 1999. I don't think they've really surpassed the 89 in terms of functionality. I ended up selling the 92, as it was replaced with the functionally-equivalent 89 (in the familiar TI form-factor), and gave the 85 to my sister, so today all that remains is the 89 and the 86. I have fond memories of playing games and writing small programs on TI graphing calcs (ticalc.org still exists, apparently). At first only BASIC programs were supported, but then some folks figured out how to hack the 85 to run assembly, which continued on the other models. TI fought it at first, but later reluctantly supported assembly programs. Some enterprising hackers managed to implement rudimentary audio support via the data port, which I thought was quite impressive. The 84 Plus is essentially the old TI-82 platform iterated a number of times (TI-82, TI-83, 83 Plus, 83 Plus Silver, etc.)

I've been waiting for years for TI to make a graphing calc smartphone app, but with margins such as those described in the article, why would they? It'll likely take a major shift in the testing standards (i.e. allowing mobile devices) for this situation to change. Test proctors might have to become more vigilant, but I imagine if airplane mode was strictly enforced, then smartphones might be allowed. Seems that the communications features (which can facilitate cheating) are the primary concern.
Introduction to SailsJS
Weird. I'm not seeing that, even on the same setup (Chrome Version 37.0.2062.94/OS X 10.9.4).
might be just me, but i'm getting a DNS error accessing http://draft.railstutorial.org/
I didn't say anything about how it is implemented. It is software, there is always a way to attack it.
Any government in which it is more difficult to pass laws benefiting special interests.
I'm an ecologist: if you're really interested in this, his book (http://www.amazon.com/Maximum-Entropy-Ecology-Distribution-E...) gives a good background to (macro)ecology and works through the maths involved in this.
Detecting Caller ID Spoofing Attacks (2013) [pdf]
Box’s Next Act: Box for Industries
For more background on this library, read Russ' excellent articles on Regular Expressions

http://swtch.com/~rsc/regexp/
I avoided Zookeeper for a long time, due to its apparent complexity, but am now very glad I finally took the plunge. There's a good cloud formation script here (https://github.com/thefactory/cloudformation-zookeeper) I had to open up the load balancer to get a public endpoint like zk.yourdomain.com.

etcd and others are quickly coming onto the scene, but zookeeper is still the right choice if you want full featured, robust software with a good ecosystem of tools & knowledge like Curator, Exhibitor, Cloud Formation, etc...
Hi, I know you from the internet
The problem is that the "audition" is valuable work product that can be redeployed and has value to the employer whereas if a theatric audition is recorded and ever used in the final movie or anywhere, then that actor will get paid, period.
Yes, yes it is. Same as if someone referred to all women as a class. It's not fair to generalize about all women. It's not fair to generalize about all men. If you refer to men as a class, you're inherently being just as unfair as if you do the same to women.
The links to the tutorials themselves do not appear to be working.
Full face helmets - Race car drivers wear them, so why shouldn't developers?
Adult here who has taken Methylphenidate for 28 years. I would strongly suggest that weekends and holidays are also days off the medication.
Crazypro / alain94040 - thats the concern that we are facing first of all we dont want to spend money on something that we believe will not achieve what we planned to do, however we love our Brand and we dont want to give it up! thats why we are fighting for it.
Ebay login is down
I can't imagine this would be feasible for any online retailer. The only exception I can think of is if you just raised a bunch of money and want to figure out fulfillment later, but you will most definitely have UPS/FedEx trucks docking at your warehouse with any real volume. The solution seems great for someone wanting to sell random items they no longer want to own on eBay but the benefits of the easy to use app are also negatives for a business who are shipping the same product over and over. No business should settle for retail pricing, unless in the future you can get better volume rates with Shyp than you would on your volume. The implied market and comparison to Amazon seems off in this article.
"Money wins in court though." - I hope not this time around! :)
Impulse – Dynamic Physics Animations
I have been working with python for years. I tried Julia a few months back. The core language is well designed but the surrounding libraries are still far from mature. I found myself dipping into python through pycall for basic needs like URL downloading. That said, I will be going back again :-) The community is very responsive. It used to make me wonder whether the core team ever took a break.
TLDR if you are willing to contribute where Julia lacks, pl go ahead. Else, if you are looking for a stable environment, you are better off with python.
There is a difference between stopping an instance of a problem, and an entire species of problem. Just because the species of problem (municipal political corruption) persists in various forms, doesn't mean any individual corrupt politician will get off scot-free. They go down all the time, removing the particular barriers they had put in place.
Any alternative hardware recommendations, other than PCEngines @ $250?
There is a bit more detail on examples and additional calls at https://github.com/mesosphere/mesos-cli
Well, okay, but absent a time machine, you can't fix that. Any solution that starts with "well you should have thought of that before" has already failed. Mistakes happen; a system that can't tolerate mistakes is a system designed to fail.

Sounds like a great ad for more free-market solutions ;)

"Do what I want, or face an existential threat" is pretty much the dictionary definition of "force."

I'll concede that point, but the whole point of a free market is that you can't force anyone to do anything. If a deal isn't mutually beneficial then people don't agree to it. Simple as that. I use "force" everyday when I continue to not buy products from companies I don't like and help drive them towards change or extinction.

Sure, some people have more leverage than others, that is always the case. But that doesn't matter.

You're biggest mistake is thinking that it is bad when one party has a lot of say over another party (like McDonald's over their cashiers). It's not. That's called cutting out the middle man. If I can continue to do business without the little guys, or only need a few little guys anymore, I'm going to negotiate a less favorable deal with them or cut them out entirely. This is what drives progress. Eventually the big guy no longer needs the little guy, great! Cheaper products for everyone! As the big guy has more say, and it becomes worse to be a little guy, the little guys leave. A balance is reached. This is how free-markets operate. Creative destruction always hurts some people, but in the end we all prosper (when robots take all our jobs social assistance is necessary but the point stands)

Do you think GM would have negotiated such a bad deal with the dealers if the tables weren't beginning to turn in GM's favor? Of course not!
People don't matter. The vast majority of people are uneducated idiots who never decided one thing or another. The educated masses matter, those with knowledge as you call them, who have decided the trajectory of history at every turning point.
http://vimhelp.appspot.com/vim_faq.txt.html currently shows:

"This application is temporarily over its serving quota.
Please try again later."

A Google search for "vim faq" shows:

http://vimdoc.sourceforge.net/htmldoc/vimfaq.html

But it says the latest version is 6.3, which was released in 2004. I don't know whether there's a newer version of the FAQ.
Thanks rikkidi for the support! :)
Learning self-editing is great, of course, and you could still do that without a published comment average.

I think optimizing comments for upvotes is a bad idea. You should optimize for saying substantive things.
What do you mean with key commands? `i` for insert and `c` for copy makes quite sense to me.
Pointing out someone's potential bias is not a valid response to a logical argument, but it is a valid response to an appeal to authority.
Taking a ~$3 million seed round to buy customers and expensive toys must be fun. But its not a business. Can you keep this up without investor cash to burn through?
Exactly. I love open source software and use (and contribute to) it all the time, but the sad fact is that, despite the "many eyeballs" claim, most open source software is very rarely audited. I am willing to believe that KeePass is in fact implemented well and safe to use, but I don't actually know anything about the developer(s) behind it, don't know anything about the future development of the software (will it still be the same developers? Will new unknown people start contributing? etc), and pretty much the only thing that the developer(s) stand to lose by screwing up is reputation.

On the other hand, AgileBits (makers of 1Password) is a company, with actual money on the line (in addition to reputation) serving as an assurance that the product will not only continue to be developed, but will remain secure.

If KeePass screws up, some reputation is lost, people may switch to another product, and the developer(s) can just move on to working on other software if KeePass can't be salvaged. If AgileBits screws up, not only is reputation lost, but so are paying customers, depending on the severity the entire company might go belly-up (e.g. if 1Password is compromised heavily enough that it can't be trusted anymore), a lot of people are suddenly out of a job, etc. Basically, there's a lot more at stake for AgileBits, which makes it much easier to trust that not only are they going to do their job right, but they're also going to have processes in place to ensure a build never gets released externally that doesn't pass QA, etc.

And don't forget that as a paying customer of AgileBits, I can get support from them for any problem I might be having. Open source projects don't typically employ support personnel, and generally rely on the community to try and provide whatever support they can.

---

Ultimately, this comes down to the fact that this is a specialized class of software, where one breach can mean irreparable damage as the attacker now has access to your passwords for everything. For that kind of software, I really want the backing of a company, with a significant amount to lose, rather than just some unknown collection of open source developers.

Which is to say, for nearly any other class of software, I'm much more inclined to judge it based on its merits, and open source has a lot of advantages. But this isn't any other class of software.
Developer: I took one of these 20 minute timed tests, where the interviewer had access to my screen for the entire duration. There were 3 modules, one CSS/HTML, and the rest JavaScript. I knew there wouldn't be enough time to finish all three of them.

I thought it was the least effective way to probe my skills as a developer. It would have been better to talk about how I would solve those problems instead of a timed test.
Most people don't consider government intervention an act of the free market.
This is why the concept of eminent domain exists.

http://en.wikipedia.org/wiki/Eminent_domain
Here's a good read >

The best defense when a big company attacks a smaller company is to take the fight to the press. America loves the little guy. It goes back to the colonies and the Redcoats. It’s in our D.N.A. http://boss.blogs.nytimes.com/2011/10/03/defending-david-aga...
Bitcoin wallet creation went from 1 million to 5 million since last year and it keeps increasing.
Famous Feynman lectures put online with free access
See this other comment I just posted: https://news.ycombinator.com/item?id=8264450
One other thing here: credit. It relates to #5, but drastically increases the cost of doing business.

The "unexotic underclass" tends to not be very prompt at paying their bills. They often don't have credit cards (or even enough credit to get one), so the typical billing mechanisms are out of the question. Things get prioritized, and a lot of people will choose to let their bills go to collections before they pay them (if ever).

Sending debt to collections means you only get about 50% of what you're owed (and sometimes far less). It's usually not even worth going after people for less than $100. If this happens to even a small percentage of your customers, it can wipe out all of your profits.

There's a reason nobody goes after the "underclass" at any scale: even a minor downturn in the economy can cause a large spike in the payment delinquency rate. The only companies that seem to have success with these customers border on criminal enterprises: places like payday loan shops, pawn shops, etc. are popular because they provide temporary relief for the biggest problem most of these people have: where is the money for rent going to come from?
e.g. Brocade virtual router based on Intel server, DPDK + KVM hypervisor, 25 million frames/sec on dual Xeon E5-2667v2, http://events.linuxfoundation.org/sites/events/files/slides/...
> Creative destruction always hurts some people, but in the end we all prosper.

Er, no. The first and second parts of this sentence contradict each other. The people that are hurt -- often fatally -- do not prosper.
I find it helps to focus on a 'successful' path through the code, starting with an important entry-point and ignoring error conditions and validation. Once I've covered a fair chunk of what the software does, I can go back and delve into the parts I didn't understand.

I'm also wary of comments as I find they can often have 'drifted' in old code and become misleading. I make detailed notes of things that look dodgy or could be improved separate from the code.

I'd add that if the project has poor-to-no build scripts that require a lot of manual steps it's worth at least bandaging it up with a shell script early on.

I recently worked on a project that had many separate modules with independent build scripts, requiring copy-and-pasting built artifacts that others depended on, and several manual configuration tweaks post-packaging. That stuff is very tedious and sucks your energy. It's not generally a priority to rewrite all the build scripts, but if you're editing several modules it's worth being able to do a one-shot build from early on.
The difficulty would be in proving malice. If all you can prove is a bulldozer accident, then paying them the replacement value of the house seems reasonable.
It's almost like they're prepping consumers for 'real' VR by giving them something that's obviously a half measure but still works decently well.
Having just got back from the bay, I recall walking around downtown San Jose wondering why nobody is making use of open spaces there.

The talent pool isn't much different, as Stanford is just a 20 min train ride, yet real estate is a good amount cheaper and would provide more reasonable commutes for areas with even cheaper real estate like Gilroy.
Developer: At least they are trying to see code which is better than nothing but there is a very good chance that their hiring pipeline is messed up so be wary.

Interviewer: There is no correlation between people's ability to take timed code quizzes and good developers. It causes undue pressure on some candidates for no reason and we should never have it be part of the process.
https://twitter.com/roguelynn/status/507231579752902656

They are fixing it!
I've never heard of those tools before, thanks.

Unfortunately, Relay.js seems to not support colors in IRC, i.e. the "^C3i'm green^C" mIRC encoding. But it looks sweet though, and if one could just skip the "type the server and channel name" (i.e. embed on a community website), it would pretty much mimic the chat experience, only better :).

Anyway, so even if we have examples of pretty, somewhat simple and good enough XMPP/IRC clients, the next step is to get them to the world at large. That pretty much leaves marketing to focus on.

EDIT:

Somebody should bundle a pre-configured IRC server and a webserver hosting Relay.js into a Docker/Sandstorm (https://sandstorm.io/) container set and give it/sell it to companies as "awesome internal collaboration facilitator that improves communication and helps empower the teams to build products for the next generation of the web", or sth.
I understand there may be better ideas, but this is the one you wrote, and it's the one I'm replying to.

You're right that many-to-many transactions are workable in general. However, they're workable when both participants are willing. For pollution, only one participant is willing. The polluter doesn't want to pay damages, you have to force him. Many people can come together to force one entity to do something (class action lawsuits) and one large entity can exert its power to force many people to do something (government), but it's really hard for many people to force many other people to do something. When both the source of the pollution and the damage it causes is spread out, the cost of enforcement overwhelms the damages. Imagine a metro area with 100,000 road owners who are being held liable for pollution-related damages to five million local residents. How do the individual residents collect, when the individual road owners don't want to pay? Do they sue each one for 1/100,000th of 1/5,000,000th of the total damages in the area? Traditionally, this is solved by the local residents organizing and then exercising power through that organization, i.e. government.
Lead Generation Is Easy When You Read This Article
Small companies tend to launch in limited areas anyway.
I really feel like making this game. Anyone interested in working together?
SIMD in JavaScript in Firefox Nightly
My name is Jussi and I am part of the bttn team. So take my comments with a grain of salt ;-)

From my perspective, you are not wrong at all. At the moment, the product is pretty pricey - that is something we are working on.

It is just a fact of life (which you surely know) that in small quantities, hardware tends to be pricey. We are working our trim little butts off to bring down the price.

As for the simplicity, the product is very simple by design. However, we have some pretty cool things on our roadmap to keep the same magical simplicity of use while adding a whole lot of functionality. It is a balancing act we are hoping to handle the right way.
Co-author here.

I actually started exploring this book topic in late 2009 through an initial series of open-ended interviews that involved a lot of people from HN and were discussed on HN quite extensively (when it was much more startup focused). Here is that set: https://www.youtube.com/channel/UC6r4nAnkQO3VpddRSVwUVDg (e.g. patio11 https://www.youtube.com/watch?v=wuzNs-LhC_8, Alexis https://www.youtube.com/watch?v=enEqAq1x9UQ, Garry Tan https://www.youtube.com/watch?v=8Win0moC4cA).

I started angel investing around the same time and I quickly came to the conclusion that the pursuit of getting traction needed much more structure akin to product development frameworks. I also got increasingly busy with DuckDuckGo, and so it took finding a great co-author and many years to actually get this book across the finish line.

Here's the announcement post from my blog: http://www.gabrielweinberg.com/blog/2014/08/get-traction-tod...

Happy to take any questions.
Thanks Lsiunsuex. I'm more of a beginner and I doubt I'll ever run into the kind of needs that you had. What I would like to know is more along these lines. I'm a back end developer trying to learn frontend too. While bootstrap has by far the most resources online, it is often accused of being too uniform and hard to customise. I have heard good things about gumby especially that it is easy to customise. Since gum by is an upcoming framework, I would like to know if it will gain traction. Would I be wise to invest my time in gumby instead of bootstrap? Since I do not have much knowledge about UI, I'm not able to access both.
Just figured I should take this opportunity to say, I'm black (and female!) and an entrepreneur. Right now my cofounder (also black) and I are building 20 software products in 20 weeks. You can read about it at http://www.munocreative.com/blog. #shamelessplug

We previously wouldn't have applied to Y combinator because of remarks like these:

"I can be tricked by anyone who looks like Mark Zuckerberg. There was a guy once who we funded who was terrible. I said: ‘How could he be bad? He looks like Zuckerberg!’”

--Paul Graham, New York Times (http://www.nytimes.com/2013/05/05/magazine/y-combinator-sili...)

Seeing as not even a Stanford degree and overpriced American Apparel hoodie can make us look like Mark Zuckerberg.

...but hey---this move by Sam actually seems like a good sign!
Really cool project. Would have made organizing my job search so much simpler and saved me a lot of time. Keep up the good work guys.
PlanGrid just seems like one of those companies that every time I hear about it, even knowing nothing about the construction industry, just makes sense. They solve a hard problem and they charge money for it. I like those simple (conceptually!) businesses. I am rooting for them.
Ginsberg... We are a bit flattered.
My thoughts on launching Zumper's one click rental app