skysight-inc/HackerNews huggingface dataset:
Sativa is probably the better strain for pain relief, as it contains primarily THC (which is analgesic), whereas indicas contain roughly equal amounts of THC and CBD (which is anxiolytic and sedative).

A lot has been said in this debate and a sort of misguided idea that has been floating around lately is that the therapeutic effects of cannabis are entirely due to CBD, but this is not the case. Current thinking is that the cannabinoid receptor type 1 -- CB1 -- is responsible for analgesic (anti-pain) and recreational properties, while CB2 is responsible for antiinflammatory effects; these are both targeted by THC, not CBD. CBD binds to a novel binding site GPR55 (iirc) and to 5-ht1a, which is believed to be partially responsible for the prosocial effects of MDMA, but not to cannabinoid receptors. Wrt. cancer, a bad summary is that THC activates some parts of the body's natural cancer defenses via CB2 (all CB2 agonists do so) and CBD might have some strange, mechanism-not-yet-determine antiproliferative activity. However, these effects may be too modest to be practically useful (who knows?); cancers easily become resistant to CB2 agonists.

While I'm blabbering I might as well dispense with the idea propounded by some that cannabis should only be used medically in the form of precisely calibrated extract compositions: this idea, while attractive, is simply too expensive, and unfair to poor people seeking pain relief, somnolescence, etc. However, from what I've seen here today, it might not be bad to try to implement a system where doctors can prescribe a specific terpenoid ratio w.r.t. THC, CBD, and THCV; the last is an antagonist and may give strains a "ceiling" effect, which can be useful if people need to smoke all day for some reason.
Worked things out with the Wirecutter
Insurance is a cost of doing business. Coinbase generates their revenue from fees on the purchase and sale bitcoin, and from fees on merchant services. That's where the money comes from.
I'll definitely have to see these. I'd perhaps point out that there was a lot of older, bad art. It just didn't survive. ;-) And that a lot of post-modern art really does require ... either reading the labels or finding other ways to understand the art conceptually as well as from a technical perspective. Consider the entertainment value of critically acclaimed Hollywood blockbuster versus a new, experimental film: The older works tend to work better because they fit into patterns. "They are what they seem." The new ones take some getting used to: what you see isn't always what you're supposed to get. Neither has anything to do with fine art markets. Frankly, most fine art valuation seems to be like any other resource -- priced for its scarcity. Sometimes, an artists' works, and I really should look it up to see if this is true, an artist's works will increase in value when it's clear there will be no new works forthcoming. Which makes no sense if you consider that famous artists had other artists working for them, and if Apple can continue to produce great works after Steve Jobs, why can't we have a Picasso Inc. doing the same? But that's a different point entirely.

Trying (and failing) to get back on topic, 95/5 was probably unfair of me. Part of why I skewed to 95 was that I've seen most of the permanent collection at the AGO enough to discount it for that overfamiliarity alone. I mean, I'm still struck by minimal, early Canadian works by the Group of Seven, yet since that part of the gallery never rotates, it becomes part of the 95% eventually.
An RSU is no different than cash bonus. It's taxed essentially as cash when it vests so at that moment you can sell all the stock and treat it as cash. In fact, that's what I would advise with RSUs. Options, i think it can be better to hold for a year and see long term cap gains rates.
I came here to link to libyaml too but I'm glad I was beaten to it. I'm not much of a C programmer but I love reading and studying concurrency. Reading Russ Cox's code is one of my favorite things to do.
Hynix already showed 128GB modules

http://www.kitguru.net/components/memory/anton-shilov/sk-hyn...
This should absolutely be a manifesto -- So rad.
As sycthye alludes to, you should be looking at high-CBD strains for pain relief, not typically THC-heavy sativa strains.
I would argue no, because those frescos are littered with deep symbology and meaning that are being assembled in one work. The art is in the beauty of the work, the story it tells and what it represents.

I worked for a long time around 1960s/1970s abstract art. Much of it was of questionable quality in my eyes, but there are some really amazing pieces that really make for amazing and beautiful spaces.

My beef with the abstract stuff is that it seems to cut off the oxygen for everything else. Art is fashion, and the patrons of art tend to be fashionable people.
Your use case would not use more than 64gb of memory, no; but it would also run on the CPU side just fine with a $339 4c/8t 4770k. A user with that workload wouldn't need 128gb, but they'd also not need an 8 core CPU.

Put it this way: a $120, dual core Core i3-2100 released in 2011 has support for 32gb of ram. But a $1000 eight core processor, released more than three years later, for nearly ten times the price, supports just twice as much memory.

I believe this is imbalanced. And expecting to be able to upgrade a workstation tomorrow, when purchased today for likely well over $2000, is not unreasonable.
Mailbox stickers let communities display items they have to share
if you can find a game developer who cares enough to split their game's logic down more than just "render thread" and "logic thread", then maybe an 8core would be useful
Clojure from the ground up: roadmap for remaining chapters
I think we'd all like to hold on to the notion that business (and sales and competition) doesn't have to be done this way.
I think you're mistaking Lyft's strategy. They aren't principally hoping that passengers regard Uber as scummy. They hope that the (more engaged) drivers will. All of this communication about Uber recruiters costing drivers money, Uber recruiters canceling rides, but don't worry, we're safeguarding you -- it's about setting up a bad impression of Uber and their recruiting habits before the recruiter actually talks to a driver.
Side note: acetaminophen is a much bigger threat than most opioid analgesics themselves. It's directly involved in something like 10% of all overdoses in the US. There's no practical reason for opioids like hydrocodone to be mixed with it (as opposed to just being prescribed/administered concurrently) except that you get sick if you try to take enough of the opioid to get high. Personally, I feel that hepatotoxicity is a poor abuse deterrent, both in theory and practice.
Dream job = Entrepreneurship
Overloading the 512K BGP tables was a fun way for people to toss a monkey wrench into the Internet. But then, it didn't affect everyone easily and nor would cutting a cable, which not only doesn't affect everyone, but, I imagine, is rather hard to do. It's much easier to mess with the Internet using software, and by doing so remotely, you've a better chance of not getting arrested for it, I imagine.
> Frankly I'd be more comfortable writing my own t&cs than trusting these guys...

Agreed. Based on the free template this emits I don't think it's worth paying for the rest of them.
Government doesn't move at Silicon Valley's pace. The ability to cheaply track your income from all sources and bill you directly for your taxes is barely a few decades old.
Brilliant. But need to make UI more pleasing.
Very true, and more as time passes, such that the JIR isn't so funny any more.
Yes, copper cables have repeaters too. And I would expect them to work at similar voltages.

The only difference I can think of is that the amplifier power is probably a steady DC (and corresponding magnetic field) whereas the signal in copper will be varying voltages - creating a fluctuating magnetic field that repels the sharks ?
Bitcoin entrepreneur pleads guilty to unlicensed money transmission charges
The Roche Biochemical Pathways charts were the inspiration for the MetaCyc family of pathway/genome databases, all enabled by the Pathway Tools software (itself written with 400,000+ lines of Common Lisp):

Example pathway: Super-Pathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass

http://www.metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=GL...

MetaCyc has an order of magnitude more information integrated into it than most wall charts. Plus, you can get true interactive metabolic overview maps, where you can click on the enzymes and compounds (example from the E. coli database):

http://www.ecocyc.org/overviewsWeb/celOv.shtml
(be sure to zoom in and click on things!)

The Pathway Tools software, and the metabolic networks, are freely available for academic use, and you can use it to construct your own metabolic networks.

Full disclosure: I'm a former full-time bioinformaticist on the project.
I seriously doubt if this is still true. Multicores have been common for more than a decade now.

Edit: first Google hit to satisfy parent, since replying is disabled.
Valve goes multicore [2006] http://techreport.com/review/11237/valve-source-engine-goes-...
It's probably their equivalent of a Trap Street or a Fictitious Entry.

http://en.wikipedia.org/wiki/Trap_street

http://en.wikipedia.org/wiki/Fictitious_entry
Drug companies are not trying to stop the legalization of marijuana. Painkiller manufacturers has gotten into a lot of shit for the abuse of their products (some execs almost went to prison and paid $34M in fines personally; see Purdue Pharma [1]. How do they remedy that? By funding anti-drug groups. Unfortunately there are no "bud is ok, but Oxycotin is bad" groups, so they fund the ones that are anti-all-drugs. The main goal of funding these groups is to stop abuse of their own drugs, while looking good doing it.

I work in the drug industry. Trust me, none of them consider marijuana a threat. There may be one or two exceptions, but they certainly aren't the companies making narcotic painkillers.

[1]http://www.nytimes.com/2007/07/21/business/21pharma.html?_r=...
Because you're taking it out of context
There are around 115 U.S. acetaminophen deaths per year, versus around 17k opioid analgesic deaths. That said, as far as I can tell there is no reason to take it acetaminophen ever; for pretty much any use case, there is another drug that's more effective and safer.

http://www.propublica.org/article/tylenol-mcneil-fda-behind-...

http://www.cdc.gov/media/releases/2013/p0220_drug_overdose_d...
Using Pathway Tools, the pathways are automatically laid out for you in a rational manner, organizing pathways and super-pathways based on a manually-curated ontology. For example, all biosynthetic pathways are displayed side by side. Wall charts dazzle with their complexity, but it isn't the best layout for organizing information.
Eh.. This map is not useful whatsoever for reference, other than in a general "sales guy" sort of sense.

Speaking for my company, I buy these each year because A) It looks great framed in our lobby and B) I want to support continued development of such things.

When you compare them to actual fiber maps, they are accurate mostly in the general sense and not all that useful for planning specific routes anywhere.
Space spiders and their moon bases.
I think it's going to start becoming reasonable to package up applications in VMs and distributing the VMs "appliances" to run instead of installing software directly in the OS. I think this is going to start happening regularly in the consumer space sooner rather than later (and already has in some cases like with XP Mode). This is pretty much modus operandi in the service space today.

There's lots of really good reasons to do this (sandboxing, ease of installation, compatibility, snapshots/state saving, etc.) and VM tech at the consumer level is good enough for most applications. Doing so also enables you to distribute the same application for different host architectures relatively easily (swap out the virtualization core with an emulation core).

VM technology basically will allow consumer software vendors to start treating your computer like a set-spec videogame console instead of worrying about millions or billions of possible complications from how your computer is set up. Once VMs in the consumer space get good enough to really run high-end games, imagine everybody just writes to some Valve defined Linux spec that just happens to match some Steam Box, but you can install the VM for that game on your Mac or Windows or whatever and get to gaming.

If this happens, VMs will chew through RAM faster than just about anything out there.

So instead of installing and running Adobe Suite, you start up the Adobe Suite VM and boom, 8GB of your RAM vaporizes. Fire up your web browser VM and boom, there goes another 4GB. Your e-mail client annihilates 4GB more and now we've eaten up 16GB of RAM to run a handful of applications. Open up an MS-Office component and there goes another 8-16GB. Run a non-virtualized legacy app? Why those all just get sandboxed into an automatic "old shit" VM so the virii keep out.

This isn't inconceivable and I wouldn't be at all surprised if this wasn't already on the drawing boards somewhere.
Social Sciences Suffer from Severe Publication Bias
Hardly any games are able to use more than 4 cores and most can not even do that.
I find this a bit hard to believe.....how might we know the truth though?
Reactive data visualisations with Om
A problem with these wall charts and the KEGG diagrams is that not only do you not know which enzymes or pathways are active in which tissues within a single multi-cellular organism, you don't know which organisms they come from. These pathway charts are actually mosaic pathways, trying to show a summary of metabolism across all domains of life. This can be misleading, in that no one organism contains all parts as displayed.
Why? If you have a browser plugin that can display PDFs they seem as convenient as a webpage to me. Better in some ways: usually layed out better, often faster to navigate and sometimes even smaller to download considering how bloated websites tend to be now, no ads, much better looking if printed.
I don't know why you're being downvoted - that's a pretty astute summary of the public choice theory problem. It's very hard to build an effective coalition for pragmatic pedestrian issues like making it easier to file taxes. Several presidential candidates have made it a plank in their platform but it's hard to get much traction for something people only think about once a year unless you also have a comfortable legislative majority.
It's pretty easy for anyone with half a brain to target infrastructure.

I worked in places that made it difficult even for employees with a need to know to access network data and locations of wan fiber connections. Half the time, the cables are clearly marked on the street -- in New York, you call 611 and a team of people will draw on the street the locations of all telecom, electric, water, sewer and other infrastructure right on the street for you.
flags, barbados, jamaica, trinidad
A little closer, I wonder how far we are from making something a little more mundane like a Babylon 5 spinning habitat, or even a 2001 spinning wheel station. Are these just a matter of money, or is there some other fundamental technology challenges to getting those things built?

I bet future Asteroid miners wouldn't mind a cheap place (relative to going down then up a planetary gravity well) to R&R between digs.
(Amazing time lapse)girl hitting her head on a door once a day for 19 days
Plenty of governments in other parts of the world already do this. In Spain (and I assume in most parts of Europe), the govt provides a draft of your return, which most people just accept through their internet bank.
Consumers expect chargebacks to be an option, and if their bank account gets compromised, for the bank to reimburse. That stuff is possible (AFAIK) on top of bitcoin, but it needs to be funded somehow. I think that if bitcoin goes mainstream, the fees may end up looking similar to existing payment solutions.
I think it all comes down to "what gets measured gets managed" of unknown origins[1] where if we have English and Math tests for middle and high school, we in turn value it more. Particularly during budget discussions. The opposite is true in university, though once you specialize, it's easy to see the other specializations as "not as useful" as your own, an entirely different bias perhaps.

[1] http://athinkingperson.com/2012/12/02/who-said-what-gets-mea...
So I know this is an idealistic point of view, but:

1. It's documented to return `null`. The fact that it returns undefined in some edge cases is a bug. If you want to be nice about it, you can approach them and explain the upcoming behavior change as a heads up, however it's still a bug that should be fixed.

2. No sympathy for those projects here; you can't use undocumented/private interfaces and expect them to be officially supported. I do it myself, however I do it with full knowledge that every single version change is potentially breaking to me, and I make sure to have unit tests to confirm the behavior still exists in X version. I may also approach the project and say something like "Hey, I found using X undocumented interface is actually really useful, how can we expose this as an official thing?"
Im working in a weird "application platform"(looks more like a crazy userspace OS) right now and as a step 2, im planning to bind to the chrome compositor in the low level.. and build a ui framework in Go from there.. but the phase 1 is really the most important, and i think i will pre-launch before the UI kit..

The good side of it, is that you can also bind a web rendering engine totally coded in Go or bind the webkit rendering to the compositor backend..

I hope i get there soon..
And yet I notice you didn't provide an example. Honestly I can't think of one.
I was thinking that the most stereotypical "morning" riff would be "Morning Mood" from Peer Gynt: https://en.wikipedia.org/wiki/Morning_Mood

But then I listened through the William Tell Overture enough to get to "Ranz des Vaches", and -- you're right, that's the big one. I just hadn't realized that "Ranz des Vaches" and "Morning Mood" were different tunes until now!
PDF forms can do basic math (of the sort that you do when filling out the tax return) but that functionality isn't available on the IRS forms. So every year that means several hours of double and triple-checking things that should be rights only take a few minutes. It's really aggravating to consider that there are people who want the process to be as tedious and difficult as possible.
Looks a bit like nautical semaphores.

Perhaps something Ingress-related?
> That's [i.e. giving equal weight to positive and negative results] nonsense on the face of it.

If you understood the history of science, I wouldn't needs to explain this. The Michelson-Morley Experiment had a negative outcome, a null result. It was replicated by people intent on "saving the ether" until everyone was satisfied that the null result was real. This ushered in the relativistic era and modern times. But if the null result had been discarded, it would have been an extraordinary disservice to science.

Penzias and Wilson were sure their antenna was dirty or their equipment was faulty, something pedestrian, until they systematically eliminated all such causes, and were left with a signal emanating from the sky in all directions. Having falsified all plausible causes, they consulted with some physicists who told them that they had detected the much-awaited cosmic background radiation. A revolution in cosmology and several Nobel prizes resulted.

Null results have an equal standing with positive ones. But if they're not published, the same studies will be repeated by people unaware that the path has already been tread. Also, conscientious scientists always remain alert to the possibility that their pet theory is nonsense and explainable in ordinary ways -- that's also a null result.

http://www.scientificamerican.com/article/social-sciences-su...

Quote: "When an experiment fails to produce an interesting effect, researchers often shelve the data and move on to another problem. But withholding null results skews the literature in a field, and is a particular worry for clinical medicine and the social sciences.

"Researchers at Stanford University in California have now measured the extent of the problem, finding that most null results in a sample of social-science studies were never published. This publication bias may cause others to waste time repeating the work, or conceal failed attempts to replicate published research. Although already recognized as a problem, “it’s previously been hard to prove because unpublished results are hard to find”, says Stanford political scientist Neil Malhotra, who led the study."

> Negative results can be minted at 100's per minute, by trying things that are very unlikely to work.

Yes -- like Edison trying to invent the light bulb. Edison generated thousands of null results, and one positive result.

"I have not failed. I've just found 10,000 ways that won't work." -- Thomas A. Edison
I disagree. The conversation here isn't analogous to a bunch of fine arts majors talking about programming languages, it's analogous to a bunch of fine arts majors talking about (say) iPhone vs Android user experience. Their opinions on that are valuable because they're talking in their role as customers, just as our opinions on art are valuable in our customers.

If we started talking about the relative merits of different types of paintbrush then it might be more analogous to fine arts majors talking about compilers. That's a discussion for producers, not customers, but the quality of art on the market is a question for customers, not producers.

Art that can only be "appreciated" by other artists is a bit of a wank, and I guess the analogy is programs that only a programmer can appreciate [1], like an Ook compiler written in Brainfuck or the Obfuscated C contest. It's okay for the occasional kick, but if you spend your entire career making stuff that has no utility and no appeal outside your immediate in group then you're wasting your time and might as well be making lolcats.

It should be noted that the vast majority of visual artists working today aren't producing wanky stuff that gets exhibits in galleries and never finds actual paying customers. They're out there producing pleasant-looking landscapes and things that people pay good money to hang on their walls. Or else they're graphic designers or working in the advertising industry, making good money doing something useful to somebody. Sticking a dead horse on the floor of a gallery gets you more headlines than flogging off a load of $200 watercolours of beaches, but the latter is the majority of the actual art industry.

[1] Note: not the same thing as a program that only a programmer finds useful, just something useless that amuses other programmers.
The comment is smug, unhelpful, and very misleading about the pentatonic scale.

Okay, you could call any five notes a pentatonic scale, but don't let that distract you from the pentatonic scale, the set of five notes that appears in many cultures for solid music theoretical reasons.

The linked video about blues is using the same scale, just with the notes in a different order. Different modes are not different scales. D F G A C is the same scale as C D F G A. We should be interested in the fact that blues and Thai music use the same intervals, not dismissive.

The comment also continues to ramble through several kinda-music-theory-esque statements whose aim is not to inform, but just to make the author appear smart.

Yep. This site sometimes.
Actually the problem isn't developer laziness, it's just common sense. Most games are GPU and/or bandwidth bound, and cpus don't factor in beyond a certain point. Furthermore, if you wake up too many cores, intel cpus slow down so if you do have a monolithic render thread, threading everything else is counterproductive.