skysight-inc/HackerNews huggingface dataset:
Negotiation power isn't going to get you much. The Canadian gov't negotiates on behalf of 35M Canadians and gets big discounts. United Healthcare, the biggest US private insurance company, has 40M+ members. They negotiate, but they don't get much of a discount (typically).

The real reason why European countries (and Canada) pay less is because they legislate discounts. They give the drug companies no other options. I would call it arm-twisting more than negotiating.

And yes, Medicare doesn't negotiate, it legislates discounts. Medicare pays no more than the Average Selling Price for a drug (average price across all sales). It also legislated that the manufacturers pay a discount to cover the donut hole for Medicare Part-D.
Love this bag!
I love hacking on stuff on the weekends.

Just come up with a project idea and build it. It doesn't have to be that special.
I love old instructional videos like this one, it's both very succinct and didactic.
my favorite designer – amazing and talented.
> I don't understand why...

If American politicians sported their sponsors logos like nascar drivers do, things would become much clearer.
Why should they?

Intel chips blew the doors off PPC by the time Apple got around to the PPC -> Intel transition. That (and good emulation software) allowed a relatively pain-free transition for most consumers: PPC apps didn't feel any slower when run on a new Intel-based Mac. That made it fairly easy to accumulate a critical mass of users with Intel systems, yet it still took ages for native apps to become available from the likes of Adobe and others.

Fast forward to today.

ARM chips are, at best, a little slower than the Intel chips they would replace. On top of that, the x86 ISA has a reputation for being hard to emulate well. So put yourself in the shoes of the consumer: are you going to upgrade to the new ARMBook Air, if it runs all your old apps at 1/2 or 1/4 the speed (and I'm being super optimistic here) they ran on your old MacBook Air? No! You're not! You're going to stick it out until the second generation of ARMBook comes out.

That means no critical mass of people who own ARM-based Macs and are willing and able to pay for native ARM software. That means vendors will. not. follow. This doesn't even take into account that Apple have burned their bridge with Adobe (a major vendor of 3rd party software for Mac).

Last point: I think you're wrong about games. There are tons of games for Mac on Steam. Would vendors go to the trouble of making a Mac port if there was no money in it?
Some interesting testimony on US immigration and IT professionals
Makes you wonder how many people is in this situation.
IIRC it takes 6-7 years to become a lawyer in the UK.

- 3 years undergrad law degree (or 3 year unrelated undergrad plus 1 year law conversion)

- 1 year legal practice course

- 2 years traineeship (working at a law firm) before the final exam to be a solicitor

The process for a barrister is similar but not the same. I don't know what the restrictions are on what barristers can do that solicitors can't, and vice versa.
The most important point that often gets lost is to curate your photos. You should have a collection of the best of the best, which can easily be copied everywhere all the time. I have about 500 or so from the last 15 years of digital photography (my kids, mostly) that rise to this status, and about 50-60 on top.
Have you looked at the pricing structure offered under insurance, vs the pricing structure offered for the uninsured? Guess who's paying the $1000/pill? Guess who's not?

If they needed to charge everyone on the order of $1000/pill to recoup expenses, that would be one thing. That's not the issue, since they are offering it to most people (who do have insurance) at dramatically lower prices.

I know HNers are in love with market segmentation, but isn't there an ethical problem with using price to segment a market for treatment for serious medical problems based on who has insurance and who doesn't?

It's been a while since the first thread on this, but I'll just quote from the sovaldi website:

We believe that cost should not be a barrier to receiving treatment. That’s why the makers of SOVALDI offer a co-pay coupon. If you are eligible, you may pay no more than $5 per co-pay.

The SOVALDI co-pay coupon program will cover the out-of-pocket costs of your SOVALDI prescriptions after you pay the first $5 per prescription fill, up to a maximum of 20% of the catalog price of a 12-week regimen of SOVALDI. The coupon can be applied to up to 6 fills

So, if your health insurance pharmacy coverage were 80/20, instead of paying your end (20%) out of pocket, you'd pay $5 per fill. So you're paying very close to $0 per pill, instead of $1000. Well, ignoring your deductable, which might be significant, but the obamacare max is $6350, so that's an order of magnitude cost decrease for the Sovaldi prescription even if you have no other out of pocket healthcare costs that year.

The only remaining, meaningful question is: how much are insurance companies paying Gilead per pill?
I use Eclipse. What's the problem? After the initial setup for the libraries it works great - just hit build, but with the full and normally working gcc build chain.
Someone already had, I didn't find the vulnerability on my own. I merely played with it to see how bad it was
I sympathize with OP a little when he says "it's hard to meet people." I used to be very much that way. Bartending for a couple of years helped me get over it.

That said, I've been going to the gym for quite a while, and I have not found it to be a social event whatsoever. I've had about two conversations, both brief and about weightlifting, in my dozens of visits.

Doing stuff you like will generally help you make friends, but the gym doesn't seem to work that way, for me at least.
I think it is things like this that get some people wondering about the prices.

US: 3.2 million people with Hepatitis C. Price $1000/pill.

Egypt: 12 million people with Hepatitis C. Price $10/pill.
Do you know how you got the disease?
Same. I went that route because a NAS of any appreciable capacity was going to cost more for the box and no disks then my entire setup put together.
> I can't blame a company for trying to make a profit.

10% is a profit. 50% is a profit. Heck even 100% is an understandable profit. You can and should blame them for screwing humanity over and above what is reasonable.
Was the program that helped you with your co-payment run by Gilead? Seems like they will cover all co-pays over $5/month.

http://www.gilead.com/responsibility/us-patient-access/suppo...
Ireland's Silicon Valley for cows? [video]
I guess you're only planning on seizing successful R&D through eminent domain? If so, I think most people would use a stronger word than "bummer" to describe the consequently reduced R&D investment. Pharmaceuticals are a major component of the difference between healthcare today and healthcare in 1750.
A "friend" that I got into a fight with bit me. He was known to frequent brothels.
You talk about the gov't like it's powerless! You do realize that the US gov't extracted billions of dollars in concessions from the pharmaceutical industry during the Obamacare roll-out?
Another problem I wrestle with is how to hire someone with skills way outside your own skillset and outside anyone else's skillset in the company. For instance I'm in a situation where I can tell the people that have set up the infrastructure are not capable of doing it right because the infrastructure stinks by any outside measure. But without knowledge of how to do it myself, how am I supposed to hire anyone better?
kaggle is probably "the MIT" of online learning:
- Competition abounds
- Those looking to passively absorb will be lost
- To the winners go rewards and glory!

It's achilles heel is that it doesn't tap collaboration as well as it could. The future of (elite) online-education belongs to whoever can figure out how to blend competition and collaboration over the medium's limitations.
I'm pretty sure it was. I didn't have to apply directly. My specialty pharmacy handled it for me.
I have a setup like that -- gmail imap, synced with isync, indexed with notmuch. Gnus' imap implementation has gotten much faster recently, and the notmuch integration is great. On the other hand, if you're liking mutt, why switch?
That is an argument for better digital storage. Not cumbersome and expensive dead tree storage.
No, what will happen is that sometime in the next 50 years a DMCA request will coming for removal of those films due to images or music on them. One is entitled "Rush Hour" so will probably be caught up in a sweep for copies of the Jackie Chan film of the same name.

Or youtube will go out of business (like the original google video). Or in 5 years the people who posted the videos will pull them down as their business model changes.

If you want to see it already on youtube create a playlist of videos especially music videos. After about a year 10% of them will have been removed.
I find I can work quite well with a wifi hotspot (mine is ATT and I'm very, very surprised that latency and transfer speeds are non-issues) and my laptop.

However, that's basically my home setup as well, just with normal home internet service.

I have a power adapter to give me a power plug in the car for the laptop. The hotspot can usually go over a day and charges with the same cord as my phone, if I need to charge it up.

Maybe you can use virtual desktops instead of multiple monitors. They come standard in Ubuntu linux, which I run, but there's a good program for windows that does the same thing.

Edit: I'm a web developer, if that matters.
This is what I don't get.

Drug companies get shit on when they charge a high price in developing countries. When they create a program that offers drugs at prices that are much more affordable, they get shit on as well.

I see the difference in price as a good thing.
Oh, and you're not greedy? Its always the "other" guy who is greedy.

It isn't the benevolence of the butcher, baker or brewer that puts dinner on the table.
Simple Intro to SVG Animation
This sentence worries me:

> The United States health insurance system works better for costs that are spread out and predictable.

So the insurance companies want to reduce their tail-event risk. It's almost like they should buy some insurance. And they can do exactly that--it's called reinsurance.

The entire point of insurance from an individual's perspective should be to cover unexpected costs. Big costs, not small ones we can pay out of pocket. But it seems that over time, people have come to rely on their employer-sponsored plans to protect them from routine expenses like dental cleanings, eyeglasses, etc. That's not insurance--that's paying a premium to a middleman to manage your bills for you.

Insurance ought to be designed specifically for this sort of treatment: expensive, unexpected, and important.
With a Number Needed to Treat of 100, can Lipitor really be considered a "wonder drug"?

A wonder for Pfizer's bank account maybe.
Hi, I just checked out interlude. Cool project.

I think the intent of our app is slightly different than yours. Our hope was to allow users of authenticated web applications to chat with one another. Our demo is misleading in this regard as all visitors to dropinchat.com get dropped into a single "chat group" (we din't want users to need to register in order to try it out). We think that apps this product might work well with are enterprise style collaborative applications (where users are already authenticated).
We (at Rice Bowls) love Ugmonk, his designs and all the help he gives us in feeding orphaned children around the world!
Should the state create incentives for future drugs tomorrow, or enable generic drugs that allow poor people to survive today. Its a moral question, with fairly easy statements: Deny cheaper drugs, and some people die today which could be saved. Allow cheaper drugs, and less future investments might happen outside state sponsored research.

Over 30 Billion Dollars, about 1/3 of all biomedical research funding in the US is paid from tax money. The 2/3 that is left is divided between non-profit, hospitals, and drug companies. The one asking the state to grant patents is the drug companies, which is where the VC part kicks in.

It is worth talking about if this is a good idea. The sacrifice need to be talked about, openly, and admitted. It would be good to see research that show how the world would look like if that part of the 2/3 which is paid from drug companies would shrink. Maybe ask, experiment and test what happens if the incentive model could use other incentives than state granted patents. Calculate how much wealth society would gain, and could be reinvested into research, if poor people with work debilitating sicknesses was allowed to buy generic and get treated.
Stellar, a Ripple-Like Coin Promises Better Distribution
Except the road does that fairly regularly and there's padding explicitly for that.
'They' seem to be experts in the field of drug use:
http://drugscience.org.uk/about/committee-members/

You seem confident that these people have no ability to judge the economic cost, crime, family breakdown, etc. associated with each drug.

If a similar group of experts used the same methodology and produced a similar ranking of harm for each substance, would that change your mind?
once you actually find someone, make sure they have the authority to set (or help set) policy for your team.

Otherwise they'll be spending their time fixing up everybody elses code forever or get bored and leave.
I was curious about this too, definitely a nice benefit if it could purposefully trigger all types (where legal).
Just a little correction: you don't have to take interferon with Sovaldi. A lot of doctors are off label prescribing both Sovaldi and Olysio together. Olysio was actually approved to treat HCV a few weeks prior to Sovaldi but wasn't quite as effective in trials. The bulk of the revenue Olysio is generating (which is still quite a lot) is coming from doctors prescribing it alongside Sovaldi. The cost for both together is about $150k but the cure rate goes up a little bit and there are virtually no side effects because the patient no longer has to take interferon.
Fair enough :) Good luck!
> And yes, Medicare doesn't negotiate, it legislates discounts. Medicare pays no more than the Average Selling Price for a drug (average price across all sales)

ASP is a terrible price. The VA pays 42% of AWP (Average Wholesale Price). Drugs on the Federal Supply Schedule, which is what the Bureau of Prisons, the DoD, and most other government agencies use, are 53% of AWP. Medicare prices are 84% higher than Federal Supply Schedule. With their volume, Medicare should be able to get prices at least as good as what the Bureau of Prisons gets. [1]

[1] http://www.ncpssm.org/Document/ArticleID/207/Price-Negotiati...
Think of the children, seriously: http://mobile.nytimes.com/2014/07/15/world/asia/poor-sanitat...
There are apparently some such libraries already. I haven't used any, but they seem to all use process-level threading; there's no lightweight threading library (like Lwt) that uses real threads. Actually, I'm wrong; turns out it is possible to delegate Lwt threads to system threads: http://ocsigen.org/lwt/api/Lwt_preemptive. This model doesn't seem to allow communication between them, however.

1.http://projects.camlcity.org/projects/dl/ocamlnet-3.3.0test1...

2.http://www.dicosmo.org/code/parmap/

3. https://github.com/UnixJunkie/ocamlmpi

4. https://github.com/MyLifeLabs/nproc
I looked at chatango and I think the intended use case is a bit different than dropinchat. Drop-in chat provides user-to-user instant messaging. As best I can tell, chatango (primarily?) provides broadcast style communication. Is this correct?
Don't try too hard to analyze the Republican platform, as it's mostly just an assortment of special interests without any real coherent underlying ideology, and don't fool yourself into thinking a single Senator or Congressman is capable of independent thought.
Amazon.com launches new site design
Primarily, because universal healthcare involves greater government expenditure and complexity, and Republicans consider both the extra cost and regulation an assault on capitalism and states' rights. This is the party which is politically beholden to a man who famously said he wanted to shrink government down to the size that it can be drowned in a bathtub[1], after all.

Also, because it smacks of socialism, and socialism is considered a moral evil that creates an underclass of lazy underachievers who don't understand the dignity of a hard day's work and only want to feed at the government trough. And of course by implication vote for the other party.

It's probably also worth pointing out that it being the way things are done in Europe and elsewhere only makes it even more offensive, because Republicans believe in American exceptionalism - which implies at its core that our way is Just Better, and everyone else is Just Worse.

[1]https://en.wikiquote.org/wiki/Grover_Norquist

tldr; money, politics and xenophobia.
We could not have artificial IP rights and also not have significant development R&D if you'd prefer. But given those two choices I'll take what we currently have.
This is exactly the sort of thing I am looking for my SaaS. I'm awful at front end and i'm using a few templates at the moment but it could be greatly improved. You can contact me on my username at gmail.
I don't think it has to be one or the other. Why not both?
Designers of these systems need to understand that their target market can't yet read, and the whole system is worthless for small kids if you need to be able to read written prompts.

My five year old zips around the ipad and could do a lot more than he's doing, but he's just not going to take the time to sound out words and try to figure out what the game is telling him.
Transforming code into Beautiful, Idiomatic Python by Raymond Hettinger
Norvig-Style Spelling Correction in Postgres. It's surprisingly fast
Worse from the customer perspective.

All their old apps now run probably 2 to 10 times slower, until new native binaries arrived. Compare that with the PPC->Intel transition, when old binary apps stayed about the same or maybe got a little faster.

Also, emulating Intel binary apps with the CPU pegged for twice as long nullifies any energy savings, so the battery life in practice gets worse. Even if it is 20% for native binary apps, consumers are going to see "new computer, worse battery life, Og smash!" during the transition.

You're not going to see a 20% gain in battery life for native binaries, though. The only way you'd see that is if the ARM CPU used no energy at all. Extraordinary claims, evidence, and all that.

Is there really any reason to think that an Intel and ARM chip of comparable performance will have significantly different package sizes? Intel has always been the leader in process technology, so it would surprise me if the ARM die were any smaller.
Here's /r/bicycling's comments from last week...

http://www.reddit.com/r/bicycling/comments/2bp2c8/handson_wi...
I was hoping not to invest in an iPad (considering the price and way over qualified) just to use as a second monitor on-the-go. I'll look into an Android tablet while using a similar application since you've had luck working off a tablet as a 2nd screen.
This is a classic work, and well worth reading. It puts the lie to the common statements that "if an ant were as big as a man, it could lift incredible loads!" If an ant were as big as a man, it would collapse under its own weight.
I'm not saying you're lying...but this is very hard to believe. Hepatitis C passes through blood-based contact almost exclusively (not saliva). There have only been a handful of cases through human bites.[1]

[1] http://www.ncbi.nlm.nih.gov/pubmed/7811879
I am actually blown away by the hateful and bigoted nature of the comments on a site like Bloomberg.com! Didn't expect it to attract those kinds of readers.
I appreciate the way you worded it, and I agree 100% for myself. I'm hardly a strong extrovert, but something about the assurance of being able to go and find activity at any time really makes me less stressed and more effective at working.

But I accept that this may not be a helpful environment for everyone. I know I have to balance this need with the needs of my SO, who feels similarly about having forests and lakes nearby (which certainly soothe me, but don't rank as high as having humans about).
I find the "holds value" argument to hold little water. While Apple hardware does hold its value very well, most people don't resell their hardware every year or two. Yes, some people do, and they're quite organised and know what they're doing when it comes to moving all their stuff between machines and their setup, but most people don't.

As for massive slowdowns, I'm having a problem at the moment in that everyone I know with an old 4GB ram mac is having a massively slow system once they upgrade to Mavericks. On a clean boot, these machines are already using 3.5-4GB, which makes no sense.
Did Ancient Egyptians Trade Nicotine and Cocaine With the New World?
Losing native Windows virtualization seems like a big deal. That was a huge selling point with the switch to Intel. It's become indispensable for many Mac users and was the reason many Windows users were able to switch.

Unless Microsoft also drops Intel, I don't see this happening.
Hipvote, gamifying congress since yesterday
Uh... why was your reletively cheap "nas-in-a-box" exposed to the public internet? I don't even let my NAS as the office be exposed to the internet!

- Also, for what it is worth, FreeNAS is amazing, and is open source.
as an example, I met one of my good friends there. It started with smiling and nodding, and one day I asked him about an exercise I didn't do and asked why he does it. Asked him to watch my form while I did it.

From there it was just getting his name, and whenever i saw him at the gym he and I made small talk (I made an effort to do this). Asking about how someones day to how their weekend goes a long way (it's very normal for people to do this in general).

I also sympathise with the OP, as I had problems forging relationships. But I just kept at speaking with people, and showed general interest in the things they do and soon enough they start asking about me.

When they start asking things like: got much planned for the weekend etc, it will usually lead to "want to come out with us". I am not sure about your environment at the gym, but we have a very friendly group of people.

It doesn't have to be gym, it could be anything from pottery classes, to painting or in my example the gym. Just have to get out there, and do things with people :)
Dude read the last line. I explicitly stated precisely that.

> I'm not sure it's a good idea because it might well reduce investment in new drugs (developing drugs is like VC, you fail a lot and occasionally hit it out of the park) and that would be a bummer.
Check out the current Thinkpads; they might also have something that suits you.
I'm a Democrat and generally in favor of state-sponsored universal health care, but unlike other commenters on this subthread, I don't have a hard time seeing the issue Republicans have with single-payer healthcare.

Single-payer essentially nationalizes more than fifteen percent of the US economy (by dollars). It would more or less make every doctor, nurse, and technician an employee of the US government. But much more importantly than that, it would remove broad market price discovery from allocation of medical services. Instead of prices rising or falling to match demand from actual consumers, things would cost what a system of bureaucracies would say they cost.

Republicans aren't simply concerned about single-payer because they oppose entitlements (although they do). They also have a valid concern that single-payer would distort and degrade the health care system.

(For what it's worth, I like the balance Obamacare tries to strike, and support anything that puts us further along down the road to the Swiss system of health care).