skysight-inc/HackerNews huggingface dataset:
My insurance was gutted and my deductible went from 200 to 2000 a month during treatment of this. I was accepted into the 5$ program. I told them I couldn't afford it. Getting approved took 10 minutes. One other thing to note is this drug doesn't work alone. You have to take it with Ribasphere, which can also be costly.
if it's not simultaneous, how does the country ever become a tablua [sic] rasa (a blank slate)?
No. What screws humanity over is a system where nobody is incentivized to producing new drugs. If it is so effin' easy, you do it. Go ahead. Raise the hundreds of millions of dollars and promise your investors "you know, we're only going to make twice your money back". Its not that simple. I'd rather have the option and have it be expensive as hell than not having the option at all.
Does anyone know a good open-source version of this type of functionality. I have a client now that wants me to add this to their site but the data cannot go through a third-party company.

My stack is django-based but I am open to any solution that works well.
I think weekends when you're single are best used looking for a wife. Once you're married the weekends are for you to give your wife a break by playing with the kids so she can relax! If you can squeeze something else in, whether it be a hobby or a second job, more power to you! I don't think you ought to fret too much "what's the best path"... just pick something and do it.

As for your company's opinion, remember the ancient maxim "It's better to ask forgiveness than permission". That was Julius Caesar upon crossing the Rubicon, wasn't it?
My parents just upgraded and sold their old (4 and 5yro) MBP's for a yearly "cost" similar to what I saw ($240/yr, it was a little closer to $300 for them). I will agree that selling and re-buying every 1-2 years can increase your savings but the fact that a 4 & 5yro laptop is worth anything is testimate enough IMHO. You don't see that with windows laptops.

Please show me a windows laptop that is still worth even half it's value after 2 years.
They are also making efforts to make it available in other countries where healthcare is hard to acquire and the disease is widespread for significant discounts.
Ukrainian forces on outskirts of rebel-held Donetsk – CSMonitor.com | YoNews.org
I don't really have anything to prove, this is a throwaway after all. It's certainly something I wouldn't announce publicly.

That being said, it was a pretty bloody fight.
A mate of mine once said you can rate the quality of a society based of the quality of their toilets.

At the time I shrugged it off a bit, but certainly there's a bit of merit to that statement.
I'm not planning on it. I explicitly talk about the tradeoffs. I'm more speculating on what happens in politics which is "we do whatever we feel like and make up reasons why it's OK and legal"

Which is more valuable: a definite life saved today or a potential life saved in the future? This is the constant struggle of everyone involved in economics. We never know the counter-factuals.

Perhaps some drug company is on the verge of an HIV vaccine but because of the eminent domain seizure they stop the program and we get a hep-C cure but lose an HIV cure. That'a a "bummer" or "travesty" or "moral outrage" or whatever you want to call it.
stupid naive user (on linux xmonad firefox) question:

"Drop a CSV or an Excel XML (.xlsx) file here to import it"

what sort of left-mouse/middle-mouse or ctrl-C/ctrl-V does "Drop" refer to in the above?
Other than 'some people might not be so wealthy' I haven't heard any good arguments against a given country moving all pharma research over to a government agency. (Most arguments are emotional / political / historical / naively optimistic about the current situation.)
Interesting! So I guess there aren't any other tablets that support miniDisplay as the method of screen extension for Macs?
ASP is not the best price, but it's certainly not "terrible". It's the average price including all discounts offered to private insurers.

The 42% of AWP that the VA pays sounds awesome, but AWP is inflated (typically 20-40% more than list price).

At any rate, yes, you are correct, the big four (DOD, BOIA, DOC and one I can't remember) get very discounted prices. However, they can also exercise a lot of control over what patients get without having to hear a lot of complaints. For example, the DOC is not using Sovaldi all that much, but if prisoners complain, not much is done.

Now imagine if Medicare said "no, too expensive, we're not paying for that drug". Congressmen would be getting hundreds of calls from seniors and the AARP about denying the elderly population the latest and greatest drugs.
Oh it's written in Go? That's so cool! Can you tell us more? Maybe do a Show HN some time.
Or recruit a network of subcontractors that you can farm work out to, earn money from brokering their labor, so you can do more projects with less personal time invested in each.
If you are willing to build on go, we open sourced the "wc" (WebChannel) library which handles all of the messages for dropinchat.

http://gopkg.in/samegoal/wc.v0

Also, out of curiosity, if dropinchat provided a virtual appliance so that you didn't need to send the messages off network would that address your security concerns?
Being able to hang a tablet off of your laptop's screen (like the way that kickstarter project mentioned by someone else does) would be nice. By the way, my laptop bag has a convenient pouch for a tablet.
Is it that brainy people moved to cities, or that cities made people brainy?
Fair point, but also consider the options we have in terms of reducing cardiovascular complications. Most of the other drugs don't work as well and have more severe side-effects. It may not stack up well against other drugs, but for CV disease, it's the best we've got for reducing CV risk.
Drag and drop a file from a file manager to the browser. Thunar is a pretty lightweight file manager that supports drag and drop.
> Where would the money come from?

Same place it does now - the end user. But the money would cover research, development, trials, data mining, treatment, etc. It would not be used to mislead medical practitioners, patients, or government officials.

> Right now the NIH's budget is $30.1B. US pharmaceutical companies invest $48.5B in 2012. Note, that's only R&D expenditure, not all the capital costs ...

US-centric may not be the best way to come at a discussion about health costs (no disrespect - just it's not typical in the world stage, and you'd be hard pressed to find someone that considers it best practice).

How does that R&D component stack up against the industry's Sales and Marketing budget? (Hint - less than admirably.)
You are correct! I think Sovaldi's label has with and without interferon, but standard treatment often includes it.

Later this fall Gilead and Abbvie will be launching all oral combinations, so interferon will pretty much be gone by end of 2014.
Kaichou Wa Maid Sama Capitulo 17 Sub Espanol HD
I accept that there is some skill and training required to run an experiment - particularly with hard sciences - but generally far less than is required to design it and analyze the results.

To extend your metaphor, it would be like saying that only people who design jetliners should be able to fly them.
psychology nigger is in the dark

Stupid fuck.

I made a compiler. I am a god amongst programmers, you dipshit.

There is a device called a GPU that every computer since 1993 has had. Oh, you obviously don't really need a GPU, right? They just rip everybody off because they are stupid.

There are 50 different GPUs with different drivers. You think I should try and get documentation on the one which I happen to own. After spending a year on my GPU, I can buy another computer and then there will be just 48 GPUs that I do not support.

I did HD Audio. It worked on 1-in-5 computers. I got rid of it.
Thank you! (i feared as much)
The health care industry contributes substantially to both parties, even though the Democratic party supports single-payer. They contributed more to the GOP in the 2000s, but the GOP controlled the government for most of that time and held the presidency. Starting in 2008, health care resumed contributing more to the Democrats, as they did at the start of the Clinton administration.

The idea that politicians assume public policy positions because they're captured by donors is sometimes true, but it's incorrect as often as not.
Testimony: USA and its useless immigration policy
I do look forward to the day where such complex congestion control protocols can be implemented in hardware...

Until then... fq codel is the best thing going.
I find that when coding, one display works fine (just my MacBook). But much of my day is comprised of moving between ArcGIS and Excel, so two screens work MUCH better when comparing tables within Arc and Excel.

What are the benefits of using a personal wifi hotspot over tethering your phone to you laptop (other than, I guess, going cordless)?
I think the overarching point is that "storytelling" simply can't work in the same manner as it does in books and movies.

If you tell a story in a cutscene, you then aren't playing a game at that point. Or if you plot out every possible interaction (kind of like The Walking Dead games) you have to limit the outcomes to a manageable level, which hamstrings the gameplay. So what's the solution? The article is arguing that you have to abandon narrative and focus on what you want the player to feel directly.

The problem is that "game literacy" is focused on all the wrong elements. A game like Doom has much better, tighter, more interesting gameplay than something like The Last of Us. (which I still really enjoyed!) And you can be moved by the story, characters etc. from The Last of Us, but it's a lot more like how you feel watching a movie. With Doom, people create their own narratives by interacting with the game, and those narratives have a different kind of power. People still tell stories about playing Doom for the first time 20 years ago with their friends. The objective, I think, is to make a game where those personal stories are directed to achieve a specific effect.

There's one example of this effect that I've read about before. There was a game in the 80s where you play a war game as either the U.S. or Russia. If you play as the U.S., you stockpile arms and try to win the war as you'd expect. But if you play as Russia, you have a whole different set of concerns - starvation, winters, limited resources, aggressive neighboring countries and other factors which lets you experience some of the desperation Russians must have felt during the Cold War. It's a pretty powerful story to tell through gameplay alone, and a story that was told through gameplay without narrative.
The most amazing thing is the simplicity of the drug in its chemical structure. Anyone with a chemistry background would recognize it as a modification of the RNA nucleotide that you learn in a undergraduate biochemistry course.

Every few years people seem to think we've found all of the significant small molecules for human disease - they keep getting proven wrong.
I love imapsync to death...I'm just not sure why you posted it now. >.>
Agreed - I have yet to successfully send a text through voice commands. Or navigate. And I quickly realised it was dangerous to try, because I would inevitably have to look down to see what the phone is actually doing.
Send them a pull request that adds an option to click to browse for a file, too.
Yes, we really need UX assistance. :-)

Tracy Ruggles helped getting a better formatting UI (modeled after CKEditor at that time) for Socialtext — screenshot at https://www.socialtext.net/help-en/socialcalc_move_source_ex... — but something more touch-friendly and intuitive (post-bootstrap) would be awesome.

Please get in touch on ethercalc repo or write me if you know a UX designer interested in revamping our UI!
Disappointment is what you get when you do not try. Comparing solutions designed by people that had a benefit of knowing MIT's mistakes is simply wrong. In the end what MIT did was put free knowledge on the internet with their trademark scale and they had done that way before anyone else. I think that inspired a lot of people and without that first step I doubt we would have anything as good as we have right now.
hahahahhahahahaha
It utterly hadn't occurred to me that there'd actually be a cultural issue on something like this. It's an incredibly alien concept.
I think the US is a good example since most pharmaceutical R&D is done in the US. Also, the NIH has a pretty beefy budget. For other countries, the cost of running their on pharma companies would be much more burdensome.

To answer your first point, you're saying that the cost of R&D would still be born by the end-user (patient). What's the benefit then if it's not saving money?

If you think a gov't run company would not pull some of the same stuff the private ones do, I'd have you take a look at some of the corruption that goes on at public companies. A gov't run company might not be for-profit, but someone there has budgets and revenue numbers to meet. The motive to cut corners doesn't disappear when it's run by the gov't.

And why shouldn't a pharma company have a sales and marketing budget? Do you think your doctor has time to sit down and analyze all of the clinical trial data? Getting in front of a doctor and touting the benefits of your drug sounds like a good thing to me. Sure, some sales reps use slimy tactics, but overall educating physicians doesn't sound like a bad thing.
> Single-payer essentially nationalizes more than fifteen percent of the US economy (by dollars). It would more or less make every doctor, nurse, and technician an employee of the US government. But much more importantly than that, it would remove broad market price discovery from allocation of medical services. Instead of prices rising or falling to match demand from actual consumers, things would cost what a system of bureaucracies would say they cost

Eh? Universal healthcare doesn't mean price regulation. The price signals are still there but you now have a very large public buyer able to negotiate prices with very big private suppliers. How is that not better than the current system where large numbers of citizens cannot afford adequate healthcare and big companies can extort whatever price they want out of those seeking access to life-saving drugs?

> They also have a valid concern that single-payer would distort and degrade the health care system.

Degrade how? Universal healthcare can still work with e.g. privately-run hospitals and clinics. You don't need the government to hire all the medical practitioners; just pay for the cost of treatment.
I've thrashed the bag over the last few months in terrible weather, and it's been outstanding. Jeff's quality of work is second to none, and I'm very happy with the product for what I paid. Why buy a bag yearly when this could last for 10 years? It fits 13 and 15" laptops, and I couldn't see myself using anything else for the foreseeable future.
That kind of sharing doesn't even have to be explicit. Once this information is in the FCC's hands (and who does that mean exactly? Wheeler? Wheeler's assistant? His gold buddies? His wife? Last I checked the FCC is not full of spies with top-secret clearance, but rather a bunch of ex-telecom execs), it will slip into the hands of the big companies without anyone even revealing it intentionally. Just by knowing the data, people at the FCC will slip up in conversation with cable execs, accidentally saying just enough to imply the details of a peering deal. e.g. "That's all Netflix is offering you for that level of peering? I'm surprised, seems much less than average." A sentence like that is all it would take for a Verizon exec to infer that Comcast is getting a better peering deal from Netflix than him.

All that said, personally I don't see why these deals shouldn't be open. If you ask me, peering should work the same as ad-serving. That is, there should be an open marketplace for BGP routes where companies can submit real time bids to each other. Anyone with sufficient routing, whether Netflix or a small startup, should be able to participate in the market. Let supply and demand determine the deals.
I remember playing the original Lightbot on Kongregate back in 2008, and still remember thoroughly enjoying completing it. I've always had a soft spot for well-made puzzle games and for some reason I've never really connected that to my natural curiosity with regards to programming.
> 1. How can you recognize that someone is actually a better programmer than you are, as opposed to someone who can bullshit beyond your ability to detect it? (It may be easier to detect that someone is a worse programmer than you are.)

This question comes up a lot, and I'm not sure that it's really as hard of a problem as it's often made out to be. Especially if you're having a candidate write algorithmic code on a whiteboard, I think there are ways that you could judge whether they're better than you:

1. They solve your problem faster than you did (the first time). Of course this assumes you have a novel problem (i.e. they haven't practiced it before), etc.

2. They solve your problem and in the process of doing so teach you something unique. Maybe their solution is faster or simpler than yours. Maybe they catch some corner case you didn't see.

Another way to look at this is that if you make up your own (difficult) interview question, and then use it repeatedly, you will eventually become an expert on it. As you watch other people solve it, you'll learn various tricks for solving it, and will see it from many different angles. You'll also become aware of common pitfalls.

So when someone walks in the door and has never seen your problem before in their life, you have them at a disadvantage. Now if they give a solution that's as good or better than yours, what does that mean? It could just be that they're solved similar problems before, but maybe they're better than you.

This approach does assume that you are good enough to create a novel question, which in and of itself is a difficult thing to do...

[EDIT] One thing I left out is that while I believe it's possible to say "this candidate is probably better than me," there's an upper bound on your ability to see exactly how much better they are. In other words, it might be difficult to tell the difference between someone moderately better than you and someone vastly better than you.
Most of the world lags far behind Japan, then.
YC Hacks Winner: Athelas – Blood imaging and analysis from your smartphone
It's from the same author who made Mosh, a mobile shell/SSH replacement that will keep you sane with high latency/lossy connections to your servers.
Show HN: A 16-bit Forth machine written in VHDL
I always found the idea that India has a sanitation problem because it's too much money to build a proper one confusing. I mean, most Western nations built their sewer system when they were much poorer than India.

It now seems like they don't have proper sewer systems because there just isn't the demand.
no-one 'advises' 18 students... this professor has a successful small business producing publications with their name on them - this is both sufficient, and increasingly all, that is required of them in academia. if their reputation is high enough you can springboard from here into your own academia-small-business start-up YMMV but you can be sure of the up-front costs!
Very nice, I'll be keeping an eye on this. I'm sure you guys have a million other things to do, but don't forget handling multiple tabs by the same user.

e: Ah, and somebody's already trying to inject javascript. You rascals ;)
Let supply and demand determine the deals.

In other words, let ISPs' stranglehold on their customers run totally unchecked.
I hope they can figure this issue out. As a westerner who never considered not using a toilet, I'm having trouble understanding the pros and cons of using toilets at all.

What happens if a person defecates in the fields? Does this spread bacteria to other people living nearby, or people who eat crops grown in those fields?

What are the beneficiaries of me using a toilet instead of the fields? My family? The people living nearby? Hopefully providing accurate information on these matters will help villagers make better choices.
If there's a single federal buyer paying for 90+% of the market (look how much of the market for seniors Medicare covers), it's hard to see how the price signals continue to work the same way. The (slow, error-prone) political process is engaged in every buying decision.

Already you can see that changes in the way Medicare reimburses and measures outcomes have impacts on the way services are delivered today, and Medicare is just a fraction of the overall market for health care in the US.

The federal government doesn't hire all the practitioners. They just fix all the prices.

At any rate, there's a difference between disagreeing with an argument and pretending that it doesn't exist, as other comments on this thread did.

(I am in part assuming the mantel of the GOP argument against single-payer here; I prefer the Swiss system to the NHS, but unlike most Republicans I strongly believed that a national solution was needed for health insurance and financing.)
what the hell, i tried a few images from unplash and it worked flawlessly. how does this magic work?
I'm not sure if this is very helpful, but my two big issues were the lack of pages, of course, but mostly--the lack of text formatting for each cell. It makes the actual spreadsheet hard to read.

I've still going to use it because yes, it's very necessary to have a social spreadsheet platform that is open-source and that you can host on your own servers. Thanks for the work you put in.
YCHacks Photos
I think we're agreeing.

I was suggesting that Xcode should use real directories on disk.
Pigment print? What about a regular pharmacy 1-hour photo? That's an actual photo, not a print.
Japan has some of the best (heated seats, built-in bidet, etc), and some of the worst (squat-style, no toilet paper), so on average Japan is just so-so. Of the 40 countries I've been to, the United states has the best average toilet standard.
How is this different than lifelens?
The Windows kernel guys were evaluating ARM systems for us, and the gist was "Run away, don't walk; the memory systems on those things are terrible."

I like the ARM architecture a lot. It's simple and easy to write software for, all the way from embedded controller stuff to "real" operating systems. But they're not all that great at doing massive computation. We were going to use one in the video path of a popular gaming system for a while, and it turned out to be inadequate by at least an order of magnitude (probably a factor of 100, but comparing CPU cycles to GPU cycles is pretty unfair).

Intel is executing really well, and it'll probably take an alien invasion to dethrone them.
You may also want to look at offlineimap.
About a month ago, a study came to the same conclusion about modern Americans. That is, Americans born in rural areas who move to urban centers have higher cognitive ability on average than their counterparts who stay put.

Overview Article: http://www.citylab.com/work/2014/07/the-smartest-people-move...

Paper (paid gateway, can't find free): http://www.sciencedirect.com/science/article/pii/S0160289614...

Anecdotally, from my own experience this isn't surprising at all. I grew up in a small town, and wanted to move to a big city since I was about ten years old. I just got bored in that small town. Seeing the same < 100 people every day, going to the same places... It's simply not as stimulating. When I went to boarding school, I found that many of my peers from similar backgrounds felt the same. Eight years later, almost all of us are living in a big city. Maybe this will change as we begin to have families, but it does seem that we all had an instinctive desire toward the draw of big cities.
Looks great, but please don't put "Show HN" in the title until the app is ready for everyone to try out: https://news.ycombinator.com/showhn.html. Good luck!