skysight-inc/HackerNews huggingface dataset:
I am curious about the timescale of treatments for terminal diseases, and how trials can be morally randomised.

It seems to me that a very high percentage of people would opt for a potentially fatal, completely untested course of action as opposed to imminent death. So who gets to try these treatments, who tells dying patients they are not allowed them, and is there a black market or large amounts of money changing hands for experimental procedures?

Ekianjo in this thread quoted 7 years at the earliest for a treatment to become available. Surely with hundreds of thousands of desperate, dying, last chance sufferers, it is better to go to extreme measures and offer the most promising yet dangerous treatments to everyone. Is it simply a side effect of the way pharmaceutical companies have to do business? If so, it's sad, and maybe a larger share of cancer research money should be put towards 'out there' attempts to cure terminal patients.

Genuinely curious.
Xiaomi launches 49-inch 4K TV for $640
Probably a lot. They're fairly similar publications. Indeed, I wouldn't mind subscribing to the FT, but I simply don't have enough time to read as it is.
This Harvard Professor Wants Your Help to Take Over the Government
Enable JavaScript, and then click on the headings I think you mean.
> On the other hand, X/0 (integer division-by-zero, where X is not a floating-point value either) usually does cause an exception.

That's true for x86, but not for most other architectures.
JQuery Gant editor. New release with collapsible trees.
I'd love to see a messaging system set up to treat any of these JS Beebs currently running in any browser worldwide as though they're all on a single Econet.
Yahoo wants the developers not their ideas.
The project has entered maintenance mode. All development has ceased.

Yeah, I know what it means, it felt a bit weird at first (I'd go for dissection to be honest). But languages don't change based on math principles. It's from context of game/software postmortems:
http://www.gamasutra.com/features/postmortem/

Queer means strange, except it doesn't, gay means happy, except it doesn't.
The AI behind Watson
I don't know anything about "Common core" but parents wanting to learn new methods of teaching math and arithmatic may like "Maths for Mums and Dads" http://www.mathsformumsanddads.com/
Do you have the link for that topic ?
What if the side effect of the untested treatment leads to everyone in the hospital becoming infected or dying?
Odd planet, so far from its star
Same, sent them an email though.
Project Cider
The killer for using iTerm2 is the ability to drop another split in with Cmd+D/Cmd+Shift+D. That's pretty much the only iTerm2 feature that I use with any level of regularity, but it's awesomely handy when you're working.
I assumed that already happens. It certainly does on loyalty and store cards.
As Bitcoin startups surge, Paris opens its first Bitcoin center
Well what are the four ways to do addition?
Well in this case it's obviously different. I'm talking about actions that have consequences for the dying individual only.
Moveable Type was the first blog system I used, over 12 years ago. Oh the memories... my first exposure to Perl and setting up sites on a shared host. Slacking off in university labs to tweak the theme files/write posts/work out why site rebuilds were taking a stupidly long amount of time... fun times :)
Air Force Spending $60 Million for SpaceX U.S. Launches
That's sorting, not filtering.
Project Cider Shows iOS on Android, Highlights Segmentation Problems
If you are familiar with Jekyll, I have made a plugin for Jekyll, for easy album generation. You just need to put your photos in a folder, and the web page can be generated. But you need to customise the theme yourself.
Anyone from coinbase here? Are there plans for international universities? Mine does not use a .edu but rather a country specific one. Would love to hit all students with this but I need to know first that they would be accepted.
Essentially, when you boil it down, yes. Ish.

The difference being that I'd not be holding anyone to ransom for money, which is what those calling for an end to what neutrality still exists essentially want, I'm instead suggesting that we give the people who aren't doing that a "thankyou for not being a dick".
It does mention that. Read again :)
It's valid morally. However, science runs on grant money and grant money will usually only be given to projects that show a proper scientific method. It would be nice if there were some sort of open market, where terminally ill patients could opt in to clinical trials. But these trials must be tightly controlled, or their results are meaningless.
Why not just

ssh remote_host command_that_prints_stuff | pbcopy

?
You can search for "Click to play" in the settings and disable plugins until you click on them. This helps a little security-wise, too, in case an attacker is resourceful enough to have both a 0-day for Flash and the Chrome sandbox. Not sure how likely that is, but it's also trivial to white-list sites you trust not to send you exploits from the icon in the URL box.
It was a typo, but it was supposed to be the -W flag not -o. Fixed now.
Why Atom Won't Replace Vim
You're right, thanks!

https://github.com/jaspervdj/static-site-generator-comparison/commit/610b1b35742a281a84bfb18cf026842d1b92bf67
I thought it was posted for its design which is a bit OTT for me. I'm pleasantly surprised to find people talking about the content - IMHO thats quite healthy :)
The same reason you love it is the reason I don't use credit cards. I don't like anyone having paper trail of all my purchasing history. And I don't use any loyalty cards, since that's just another way of tracking. Offering 2% payback on credit card purchases gives those companies a way to upsell you a lot of unwanted stuff because they can target you very accurately, and in the end you pay more in total.

I like the fact that in Germany people don't use credit cards at all, and EC cards rarely, or only for purchases they deem are worth to be tracked, like utility bills or similar. Then, if my landlord complains that I didn't pay on time, I have my bank on my side to happily provide transaction id of the payment as an evidence.
The "cellos" voice always sings that song, regardless of the words you ask it to speak. The syllables were chosen to fit the song.
Virus therapy has been on the table for a long time in the cancer fight. Because we can manipulate a virus and have it deliver highly targeted attacks, the idea of destroying cancers while ignoring healthy cells is sort if the holy grail of cancer treatment research.
JQuery Gantt editor. New release SVG with collapsible branches
demos look quite nice but wow they take a long time to load, took about 5 minutes to download 50mb for a short scene, makes me wonder if download times are going to be a limiting factor in webgl games.
The sheer number of symlinks put me off git-annex.
I would guess that the acm could do better then showing me a 500 error + a full stack trace of a ServletException
I would argue that as a terminal patient, I certainly would not want to be part of the control group taking a placebo or no treatment at all, and that the scientific method could still be applied later when you still have a lot of people that took the treatment compared to a lot of people who didn't, for one reason or another. I imagine scientific grants could be funded on an individual basis, if the individual is rich enough.
It's not just that. If it's not properly and exhaustively tested, then they open themselves up to litigation by people who recover less than 100% or who have a new symptom.

It's also worth noting that there is a constant sussurus of "miracle cure for foo!" that doesn't actually pan out in the long run.
> Go fullscreen. Not so much for the real estate but for the mental switch. Fullscreen mode is a way to immerse yourself into your productive development world. No browser, no mail, no application notification. Only code.

This is an excellent point and one that's not nearly as appreciated as it should be. Fullscreen mode was written off in Lion as an example of Apple dumbing down the platform and making it more like iOS, but it's the perfect mode for writers, coders--and really just about any kind of creator who needs to focus.
The comment was indeed a bit disingenuous :-)
Feynman Technique to learn faster
Did not work for University of Twente emails (utwente.nl). Please know that all Dutch public universities are firmly within the top 500 of universities worldwide (whichever ranking you pick) but don't have .edu email addresses!

It's a shame, because I know a lot of people who would like to experiment with Bitcoins.
Show HN: Turkish Prime Minister manhandles citizen @Soma @Turkey
Here is an x86 emulator in Javascript running Linux 2.6.20 for those who might have missed it (2011): http://bellard.org/jslinux/

From the awesome Fabrice Bellard (qemu etc...)

Edit: Formatting, additional details
I've built a Flickr plugin https://pypi.python.org/pypi/pelican-flickr for Pelican. You can embed your photosets alongside your posts & pages...
It's not static, because I don't want to have to rebuild everything just 'cause I added a new photo, or fix a type.

Some generators (e.g. gostatic) can track changes and dependencies, rebuilding just what changed.
Oncological Virus, or OV. Pushing science fiction. But did Washington Post forget to mention the 2nd patient they released data on, who didn't have any kind of prolonged response?

The paper presents 2 cases, selected because they were the first 2 cases to be tested at maximum viral load. There are additional people in the trial, and they will release full results once they are available.

It included two slides showing before/after blood levels and imaging. They talk about how they modified the virus to emit a tracking signal, and how they modified it to target the cancer cells. Really, really mind blowing and impressive work. I would love a tour of that lab.

These are end-stage patients for whom everything else has stopped working. One of the patients had already undergone several experimental treatments. There is some really exciting research going on for MM (multiple myeloma) treatments, and maybe even cures.

I think this is one example of the free market working well. Typical MM treatment runs about $60k / year, and with recent developments, patients are living 10+ years. Total number of MM patients is increasing both because the disease is becoming more prevalent, but mostly because people are living so much longer with MM. In short, it's a large and growing market. But it's not a cancer you can treat and have it go into remission. You get on treatment, and you stay on it and keep those levels down. The typical treatment is biweekly therapy.

But these OVs are one-time deals. So a single dose treatment is a very interesting alternative. The only problem is, MM is extremely resilient, and the cells are everywhere. It's so hard to eradicate, unless the OV is a cure, it's just another tool in the box to manage MM and extend lives.

Weird, the PDF of the actual paper was freely downloadable a couple hours ago, but now it seems the paywall is up? http://www.sciencedirect.com/science/article/pii/S0025619614...
Great overview. Thanks a lot.
Currently, there are no do-overs since the body’s immune system will recognize the virus and attack it

Can't they circumvent this by injecting more of the virus than the body can fight at once? Though it's starting to sound like regular expressions...
They have nurtured it if they did nothing to stop it. Either way, they set up their form of governance initially and then didn't bother to continuously monitor it and adjust accordingly.

They deserve everything that is happening to them precisely because of their in-action through their crappy voting. It may not be nice, but that's the reality of it. At this stage, only radical things will fix it.

"if it were ever to be subject to a specific vote then I'm certain that the vast majority of american voters would be against this."

Yes, there is the rub. They probably would vote that way, I agree with you. Except they can't. They're divided and powerless to demand any sort of referendum. Heck, one need only look at recent approval polls for congress/president/law to see that the majority are NOT happy. Yet, they plow on and do nothing except whine and vote.
You should try the direct mode, then: http://git-annex.branchable.com/direct_mode/

Normally, git-annex repositories consist of symlinks that are checked into git, and in turn point at the content of large files that is stored in .git/annex/objects/. Direct mode gets rid of the symlinks.
JQuery Gantt editor – collapsible branches | Eltit Golb
Tony Darnell DeepAstronomy "Time Of the Month" Blooper
I recommend to watch Dallas Buyers Club, it addresses the very point you make.

One could argue, how could the trials NOT be morally randomised? Are we doing a disservice by not conducting the trials in a way to study the efficacy of certain drugs.
7 Essential Security Considerations in Mobile App Development
Then vast majority of experimental treatments are worse than doing nothing. So, it's generally presented as your going to die either way would you like to help find a cure so the situation becomes less hopeless at some point in the future. However, in cases where there is a large demonstrated benifit they often end the contol and give everyone the treatment. Because extending lifespan by 10% is progress but you need a control the demonstrate it's actually better than random chance but a
10+x increase in lifespan needs no control.

PS: Wit is a great movie that deals with terminal illness from the patents perspective. If I recall correctly there is a vary minor subplot around a trial on the proper drug dosage. At no point is the idea that this might be a cure just possibility of slightly extending your lifespan at the cost of a lot of pain. It's basic cost/benifit analysis but taking higher doses is in no way presented as better.
Seriously, the chances that github just disappears off the map are about the same that the gitlab team decides to stop working on the OS product. Non-zero, but still low. However, the impact is only mediocre: It's simple to keep a copy of the repo around and just a simple to keep a copy of the wiki around: They're git repos too. The only thing you'd loose is the issue history and your network of clones.

If that's what you're concerned about I'd be more afraid of your internal gitlab server crashing down in flames because somebody fat-fingered a critical update.
Mathematically Correct Breakfast – How to Slice a Bagel into Two Linked Halves
Both very good points. To the first though, I imagine you could sign away your rights to post-treatment legal action beforehand.
A patronymic is functionally a surname. 'sur' means over- or on-; it's an additional part of a personal name. Wikipedia puts it well: "A surname is a name added to a given name and is part of a personal name". Surnames a generally a function of who you were born to, rather than a choice, just like a patronymic.
How and when did hoarding bitcoin become a myth? Last I checked number of transactions per day was decreasing. And the C2C aspect you describe is unlikely to take off given the ease of cash or tools like Venmo, and lack of availability of bitcoin apps on iOS.

The myth here is that "people want to spend bitcoin." Just take a look at the bitcoin transaction volume merchants are seeing beyond the first few days.
Doesn't BTC have a transaction fee in the region of 0.0001 BTC meaning you'll lose almost the same as with a Paypal transaction?

I don't think BTC works very well for micro payments
Soma'da son durum: 282 işçimizi kaybettik
You've clearly put a lot of time into this and I think you've done a great job. I've gathered a whole bunch of new ideas to try with my onboarding in a fraction of the time it would have taken me to figure it out myself.
Excellent website. Learning a lot from it. Thanks.
disclaimer, I work on cancer drugs so I can shed some light on your question.

> a very high percentage of people would opt for a potentially fatal, completely untested course of action as opposed to imminent death. So who gets to try these treatments, who tells dying patients they are not allowed them, and is there a black market or large amounts of money changing hands for experimental procedures?

First, for many cancers you do not die of an imminent death. Sometimes it can take 5 to 10 years to die from Cancer.Unless you are affected by a cancer where no treatent is available, there are usually multiple courses of treatments you can follow before being out of options.So patients are actually trying existing methods before jumping to new treatments. New treatments are only available in small quantities and there are strict criteria for the selection of patients. And in Oncology actually we already give the chance for patients to try new drugs as soon as the safety evaluation begins, whereas for other therapies we go through healthy volunteers first. For a patient there is not much incentive to join Ph1 since the efficacy is not proven and there is a dose escalation method so you may not get the efficacy dose even if you enter the trial. Besides, there are safety risks involved and some patients die in Ph1. So every patient signs an informed consent that they are aware of the risks involved.

As for the hundred of thousands of patients, the companies cannot support them for many reasons: as mentioned, the drugs are only manufactured in small quantities in early stages and it takes years to scale up the process. Second, clinical trials cost a lot of money, and the more you have patients the more it costs. So you dont recruit more patients than what you need to do your evaluation. This being said, most pharma companies continue providing drug even after the trial is completed to patients who see efficacy with it. Third, the larger the trial, the longer the enrollment time and the longer it takes to get the results back and therefore the longer it takes before the drugs reach the market.
There's still a similar amount of hacker stuff in the listings, but the 'interesting tidbits' seem to have pushed out the business half of HN's mission. There's barely an article these days about capturing an clientelle or hiring practices or similar.
Your comment is downvoted, but I had the exact same thought.

What are the long-term risks if we start injecting people with large quantities of a virus to battle another decease? Could that virus evolve into something much worse than cancer?
I'm really glad to hear that -- it's the whole point! New teardowns come out every week or two, as well.
How a three year old PSP game made a comeback on Steam
Really glad to hear it. Thanks for taking the time to let me know!
There isn't a single thing called "cancer". There are many many different types of cancer. What might work for one type might be helpless against all others.
Usualy placebo arms get less than 50% of the patients anyway. So most people on trials get the drug. And no, you cannot "apply the science later" because you specifically want to see the difference in PFS (progression free survival) and OS (overall survival) on both groups, and for it to be comparable they need to start with the same baseline.
In the same way that defibrilators are similar to Fankenstein's lab?
Google da ilk Sayfada çıkmak
No, the current fee (not sure if it's already in the stable version) is just half a cent: https://github.com/bitcoin/bitcoin/pull/3305
Put this in your path somewhere, find files, links, directories instantly, with globbing. Makes mdfind actually useful.

$ mdf "*invoice*.pdf"
/Users/smw/Downloads/Invoice-0000006.pdf

https://gist.github.com/smw/a21a9f675ed3358830da
With direct mode, you're operating without large swathes of git-annex's carefully constructed safety net, which ensures that past versions of files are preserved and can be accessed. With direct mode, any file can be edited directly, or deleted at any time, and there's no guarantee that the old version is backed up somewhere else.

Yikes!
Indeed. We see these kind of n=1 reports every now and then and media jump on the hype gun without understanding drug development at all.
They injected a cancer patient with 100 billion units of the measles virus, this is new stuff. It may have unintended consequences.
Works for University of Toronto - uses utoronto.ca
How Football Sounds To People That Don’t Care
Pandoc and multimarkdown are the greatest. I've never found a way to fit textutil into that workflow, though. Is there anything it can do that pandoc can't by itself?
When the treatment puts a large number of terminal patients into remission, there is no statistical reason for a placebo control. You know what percentage of such patients will die when offered a potentially revolutionary therapy that does nothing, because there are previous therapies that didn't work. If one third of your patients go into remission, one third show improvement and the treatment has no effect on one third, you know the treatment works better than a placebo.

As for offering this to desperate, last chance sufferers, unfortunately the history of potentially revolutionary cancer treatments shows this is a bad idea. If the treatment kills 90% of people within hours or days of treatment (sadly this is a realistic outcome before dosing is worked out and in some cases, regardless) then it is morally unacceptable to roll it out to thousands of people. You have to do the trials first to establish whether it works, is safe, that it doesn't cause unnecessary suffering and hasten death and what the optimal dose and protocol is. You also have to figure out how to deal with patients who do have an adverse reaction to the treatment.
This is great!! Thanks for taking the time to do this. Very helpful to learn from these companies
I find the subjective gameplay experience of super hot - trying to navigate one's way through a spatio-temporal maze of bullets - has a lot in common with touhou.
I'd really like this.

I've been reluctant to post things I've worked on (mostly open source projects, some commercial) that I think some people might be interested in because I don't want to add to the noise ratio for others (I've set a high threshold for posting, which seems appropriate, and most of those things are early stage and I don't think they are quite there yet).

It would be great if there is an area for products - including non-profit open source / vanity projects - where it felt a little less disruptive and intimidating to post new projects - particularly early life ones.
> But these OVs are one-time deals. So a single dose treatment is a very interesting alternative. The only problem is, MM is extremely resilient, and the cells are everywhere. It's so hard to eradicate, unless the OV is a cure, it's just another tool in the box to manage MM and extend lives.

Yes, the key point to watch next is to see if the MM does not come back after a couple of years.
Site says it's 47 inch?
Really glad to hear it's helpful -- stay tuned for many more.
If you've not got it already, buy Samuel's e-book - it's ace! https://www.useronboard.com/training/
The virus is gone from her system. The MM is not at undetectable levels. So unfortunately, this OV is not a cure. This particular patient, her MM cells aren't surging just yet.

I think the curative approach will ultimately come from immunotherapy, training the body to attack the cells. OV could certainly have it's place, for example as an alternative to ASCT.
People confess to crimes they didn't commit all the time, yet confessions are the end game in most judicial systems, way over hard proofs... A very sad state of affairs...

http://www.nytimes.com/2012/02/26/opinion/sunday/why-do-inno...

And obligatory, Jame's Duane's "Don't talk to the cops" http://www.youtube.com/watch?v=CkZf6_jK3Zs