skysight-inc/HackerNews huggingface dataset:
>Perhaps motivated by the high costs to taxpayers, lawmakers are pushing Gilead to explain why it charges so much. It doesn't help that Gilead is offering Sovaldi in Egypt at a 99 percent discount to U.S. prices, or about $900 for a full course of treatment.

I wonder how difficult it would be (from a legal perspective) to take a 3 month vacation to Egypt and save almost six figures.
Heh. Depends on your school, but as a "standard" thing, in their third year of college, when they'd be about 20 years old. You can apply to a specialized school, and you can apply directly to particular majors at unspecialized schools, but the generic system is that you come in undeclared and declare a major by year 3.

Specializing kids before college is hugely politically sensitive, probably off the table for a long time into the future.

(thoughts from other Americans are welcome)
How To Use Facebook To Get App Installs
It's really refreshing to see a company embrace their customer's inventiveness and tenacity rather than suing them for breaking their products.
The civil right violated is equality before the law, a right explicitly documented in the 14th amendment.

Which you would know if you had read the decision overturning Prop 8.
Good article.

Reminds me of the fact that though Thoughtworks has Scala listed as a language to adopt, they narrow it down to "the good parts": http://www.thoughtworks.com/radar/#/languages-and-frameworks...

I really wish the language was less like C++ in that you need to know 1000 things to read other people's code. But other than that, a really wild future for Scala.
It is already exist and called - Thermostatic valve with volume control. I recently installed this one
http://www.amazon.com/T17T051-SS-Dryden-Tempassure-Series-St...
So far the reason for the cost is yet unknown, except that the registry decided to sell at that expensive rate. Possibly because of available clever domains like traveli.ng, shoppi.ng, flyi.ng etc and maybe they have some overhead operating cost because the country is still in alpha stage of internet penetration and knowledge.

Whatever the case, we hope they cut it down soon.
Hey... and thank you, pdonis, for typing out the arguments I was making in shorthand notation. I salute your stamina and patience. :)
Ya we stopped all ads as well, they just had shitty results. And most of the likes for those campaigns were from people who looked fake.
Well CR doesn't really refer to moderation. It refers to restrictions to the point that it is unpleasant to most people.
I'm aware that I can look up broadcasters' call letters, but that really shouldn't be necessary.

Why cannot KGTV note * ON ITS WEBSITE * its geographic affiliation.

Worse is when you run into a newspaper site which flat-out refuses to ID its locale. Where the hell is, without looking it up, the Springfield News-Leader?

(The only hint on the publication's website is its weather forecast).

It's a * WORLD * wide web, folks. Start acting like it.
I had this in my last apartment in Tokyo.

In Japan, water is commonly heated by gas-powered flash heaters. In that apartment, the heater was controlled digitally and there were up/down buttons that would change the temperature by 1 degree Celsius.

It would remember the most recent setting between uses, so all I had to do was remember my favorite number, ensure it was set to that number upon start, and hop in.

It was simpler in function than a Nest and much less pretty, but it was functional and got me the water temperature I wanted.
Is it bad that I'm just as insulted by the so-called "spider trap"? It's so technologically simple as to be useless against anyone who could deploy a web scraper in the first place.

I mean, it's marked by comment tags that say "spider trap" right on them! Its the worst type of disambiguation system: likely to generate false positives, unlikely to catch real violators.
No idea about the twitter account thing.
1) Is really hard to calculate as you need to look at the ratio of successful to failed drugs not just this single home run.

However, drug companies spend more on advertising than research which should give you some ideas for savings.
USAF To Rollout New GPS Civil Signal
Show HN: Localby – Create posts in your area for nearby people to see
Kid Finds Xbox Security Flaw
Git essentials for SVN users
"It doesn't help that Gilead is offering Sovaldi in Egypt at a 99 percent discount to U.S. prices, or about $900 for a full course of treatment."

Time for someone to start selling medical holidays to Egypt.

Are there areas of Egypt that would safe/pleasant for a Westerner to spend 90 days for less than $1k/day?
Why is this amateur list important? It doesn't say anything new and it even makes stupid mistakes.
Torrent collections for most of the past DEF CON Media
TrueCar Files to Raise $125 Million in IPO
Yes. I was unhappy with my previous job because the company mission was to just make money providing "business solutions". I'm now working at a Smart Grid company where one of our policies/goals is to reduce the carbon foot print of our customers.
So long as the fraud is uniformly distributed, that is true. But more significant is the fact that you really can't estimate your costs and benefits correctly when the vendor (Facebook) is giving you incorrect or fraudulent data.
I wonder if they actually did the same math on purpose to set a price just below current treatments.
Quickly looking at the templates on the site, it seems that all of them include a picture. This seems like a bad idea and generally discouraged.
As a long time on-and-off chocolatey user: YAY!!!

I prefer *nix but at work I need to use Windows sometimes, Chocolatey is a HUGE step in the right direction. It boggled my mind that MSFT wasn't throwing money behind the project- it does loads to make Windows friendlier to developers who prefer CLI.

I hope they commit a person/team to evaluating/maintaining/cleaning up packages in the Chocolatey repo.

One question I have tho is why they don't just adopt Chocolatey/cinst (chocolatey install) directly? What's the purpose of get-command (besides ownership which is obviously important). Why not just fork/rebrand chocolatey? Or is that what's happening?
Without rehashing the old arguments Thatcher's destruction of the Unions would have been far harder to achieve had they not ground the entire economy to a halt frequently in the late 70's, I'm neither left or right wing in my politics (as much as possible since those labels are crude and inaccurate at best) but the blame is as much the Union's as Thatcher's in this instance.

I personally think that Union's on the whole are probably a good thing (something has to exist to balance the power of capital) but that the UK model was fundamentally broken (I actually like the German model.
I've been wanting to read that for a while. Another candidate is Pierce's "Types and Programming Languages". Has anybody by any chance read both an can compare them?
We use CPack for the moment, so you can just run "make package" inside the CMake build directory and it will generate RPM/DEB.
I don't think it will be a full replacement, but it will have a bigger part in UI- some interactions are easier with voice than with navigating a bunch of menus, like doing things while driving, some description, etc.
Jeopardy N-gram viewer lets you visualize trends across 30 years of clues
If you think that's the case, then work to appeal the 14th amendment, which grants all people, including gay and lesbian ones, equal protection before the law.

Seriously, go and read the decision on Prop 8, or the recent one on the Michigan Marriage Amendment. Both are clear and readable explanations of why gay people start out equal, and if you want to make laws against them, you have to prove that there's a rational basis for the state to do so.
Tell me what the number represents rather than what the value of the number is. How about this?

#define BUFFER_LENGTH 2048
new int[BUFFER_LENGTH];
All these resumes can be printed like a normal resumes on the paper with the same data. There is online version for online presence and print version for personal presence on the meeting with the employer.
If memory serves, it was just Dogcow. But right, it was pretty passive that he had it, and part of the question's answer. Fun night.
> Then I would place all these subjects off-limits... taboo to talk about.

And yet here you are, talking about them! And there are no secret police dragging you away, or fines being imposed, or really any punishment at all.

It's a miracle!
My initials are CR and all. Makes sense. ;)
I have to wonder - are there some techniques to build the trained models by crowdsourcing?
Corruption also happens in Europe, friend! Big steps, one step at a time.
The problem wasn't that 'medications help to balance out those chemicals' is an oversimplification, it's that the theory doesn't have a lot of support. The evidence for the monoamine hypothesis is far from conclusive. I agree with the parent that 'chemical imbalance' is a PR line if stated as a medical truth. (I am only commenting on the class of medications mentioned in the article)
There are multiple serotonin receptor types, and the "selective" types of reuptake modifiers don't affect all of them all the time in all people.

That said, too much or too little serotonin absorbed by a specific set or another can have wildly different effects.

Too much serotonin is not a good thing. So you need to balance it. For some people, this means SSRIs, for some it means SSREs. That's the explanation for the imbalance model, and it does make sense given the science.
Like mortgages and tuition assistance, government-backed insurance leads to ever-higher prices. So long as the cost gets paid, prices will rise to match.
"How much capturable wealth can I create?"
Some description of the project (really any description) would make me alot more comfortable downloading MSYS2. As it stands, I have no idea what this project is, what it does, or even what the software license is.

It's a personal preference, but having the code mirrored on a Github repo would be awesome too.
what's R#? I can't find anything significant on Google.
That only happens with greater transparency. Essentially, you have to recognize the fraud to evaluate prices properly, and my impression is that most people don't.
It's not the leaning forward (which reduces your forward cross-section), but your forward motion (which increases your _effective_ cross-section relative to the rain, which is the relevant factor in the running example.

In the case of an aircraft, since the frontal surface area is smaller than the topside area, the effect of velocity is to reduce the apparent interface.
If there were any way of settling such a bet, I'd put $100 on that right now.
I don't know if you're doing it already, but in the interest targeting you can include professions too and it will target people who have it set to their "work" on FB; plus adding hospitals to workplace targeting you can quickly close the gap

And as another handy tool, you can use the FB ads api without authentication to perform certain types of search:
http://graph.facebook.com/search?type=adworkplace&q=hospital... and build your targeting criteria

Hope it helps :)
The part where gay people are treated as not as good as straight people. The state has a legitimate interest in promoting marriage. Basically, because families. If you want to exclude gay people from that, you can't just presume they're inferior. You have to demonstrate it.
This drug is a huge jump forward in the treatment of HCV. Most patients who take this drug will be cured and they won't have to take interferon at the same time, which produces side effects so severe, many patients discontinue therapy.

So even though you have an $84K per course price tag, patients given this drug get cured, significantly reducing the overall burden to the healthcare system, especially if they don't need a liver transplant.

One of the difficult things in showing value in the healthcare system is that nobody is looking at the overall costs. Hospitals worry about their costs, insurance companies about theirs. So even if a drug saves money overall, you'll often find many healthcare providers saying "no" because it doesn't save them money.
An Art History Major Teaching Programming, Part One
Can't wait to play UT99 on Mint
Excellent post on lifting the opt-in rate for push .. The opposite side of the spectrum is user annoyance and app abandons when these channels[specially push] are used to spam
Re-targeting. It's already driving a huge share of their ad revenue and will only increase.
Why object-oriented programming is your next step as a WordPress developer
Yeah, Michael Lewis' recent interviews do seem a bit suspect. He is yelling "Hey joe sixpack, Wall Street is eating your lunch!" and then when you hear the details of the supposed "fraud" it all revolves around companies like Goldman Sachs (who work with Katsuyama) whining that they're not getting a fair shake in the world. (Oh right, Goldman Sachs is managing Joe Sixpack's pension fund via two levels of indirection- Oh noes, poor Goldman Sachs!)

Plus, the interviews he's given on 60 minutes and Fresh Air never once mention the terms "market order" or "limit order". If you don't explain those two basic terms at the heart of the HFT controversy, you're not giving people information, you're only giving them disinformation.

That said, there's obviously lots of shady ass shit happening on Wall Street every day, but Michael Lewis is not helping the situation one iota, from the looks of it.
>> you end up with an offering that is designed for the enterprise, which automatically pushes out the smaller fish.

Can you think of a utility or service that serves the needs of a wide range of businesses, from freelancers all the way up to enterprise? Electricity? Github? Dropbox? Internet connectivity? These services have found ways to charge all businesses of all sizes appropriately at fair rates, without "pushing out smaller fish".

>> I would doubt very much that Colin feels like Tarsnap is a failure of some kind - quite the opposite.

Much like the opposite of love is not hate (it's apathy), the opposite of success is not always failure (it's flat-lining). Growth keeps living things alive, including businesses. Patrick's suggestions are a bunch of ideas focused on helping Tarsnap grow.

>> Patrick's agenda is keeping the idea that what he does is worth "Large Sums of Money".

I do not know a better method to value something that is worth "Large Sums of Money" than people paying "Large Sums of Money" for it. In fact, that is the very definition of value. This is not limited to marketing people. It is the definition of a 'market'. Patrick has a track record of people paying large sums of money for his services, when he was actively consulting.

>> A much shorter blog post: "Do you know Tarsnap? It's this amazing backup solution, created and run by Colin Percival."

Lets imagine you have the experience and ability to 10x or 100x software companies, as Patrick does. When Patrick looks at Tarsnap, he sees a series of simple, straightforward actions that could 10x or 100x it, that does not necessarily require any more work than what Colin is currently doing. With that in mind, it would be impossible for Patrick to credibly and authentically write that kind of boring-ass sales-shill blog post, that would have reached a tiny audience of disinterested people.

>> This would be allowing Colin to do business on his own terms.

Colin is fully free and allowed to do business on his own terms. Patrick is also free and allowed to have and express opinions on how Colin does business. In fact, Patrick even received Colin's consent to write that blog post.

>>Patrick's post just reads as a self-marketing piece.

Having known Patrick for years, and considering him a close friend, this is the furthest statement from the truth I have read on the internet. At least, since I last reloaded the comment thread on this post.
The 24 hours of “I’ve killed the company”
You're saying that if Facebook is fraudulently charging advertising customers for more than they are really supplying, that's OK and we should all just deal with it? Really?

FWIW, the last few small scale Facebook campaigns we've run at one of my companies followed a broadly similar pattern to the one described in the article, and we too have checked against our various analytics tools and server logs for comparison, finding the quality of Facebook's referrals far lower than any other source.

However, we do have some other plausible theories about why this might be the case. For example, if visitors to our (B2C, leisure-related) site first see the ad on mobile while they're at work, they're unlikely to explore significantly at the time, but might come back later. We do tend to see a significant spike in both direct visitors and visitors via search engines while we're running FB campaigns that would be compatible with that theory.

Even so, it's very awkward to audit what is really going on with Facebook ads. This is partly because it's hard to determine which clicks claimed by Facebook are actually coming through to our landing page and which are either phantom clicks or other events like Facebook "Likes" that aren't worth anything unless they ultimately translate into paying visitors. It's also hard to track how much money is ultimately charged, because the charges they actually make where they collect real money and the corresponding notifications they send out seem to be based on arbitrary billing periods that don't necessarily correspond to specific days/campaigns where you originally set your budget.

At this point, given the number of reports of strange patterns that do correspond to our own experience, we are sceptical both about how many clicks we get through FB are deliberate rather than "accidental" and about how FB accounts for clicks and calculates its charges. As a small business in a niche market, our FB campaigns only have a small budget and usually they at least break even almost immediately, so we tolerate the uncertainties because our bottom line is usually positive anyway. Even so, the lack of transparency and amount of potential funny business we see at FB is disconcerting, and it certainly makes us hesitant to commit serious money to any FB campaigns in the future.
Medical tourism is already a market.

http://en.wikipedia.org/wiki/Medical_tourism

Now it just needs a new big Silicon Valley behind it. The "Uber" of medical tourism?
The hard problem there is the business model, not the technology.
An interesting study on the topic concluded that HFT helps retail investors and hurts institutional investors: http://qed.econ.queensu.ca/pub/faculty/milne/322/IIROC_FeeCh...
I feel kind of dumb for asking this, but how do you do that?
Of course they did this in their pricing/costs calculations, how could they not have - given that 'they' are pharmaceutical executives whose job it is to make as much money per pill as possible.

Well, if there is ever a 'place' for the open-Source ethos, medicine is it. Stories like this confirm it for me, anyway.
My current impression is that while efficacy is demonstrated for many drugs, how they work is poorly understood or not at all. Do you know of good reviews that cover what we know about why some drugs work and others don't? Preferably in more detail than 'free seratonin serum levels were increased.'
Programmers that replace 0 with ZERO, 1 with ONE, and 2048 with TWENTYFORTYEIGHT are severely misunderstanding why magic numbers are a bad thing in the first place. TWENTYFORTYEIGHT means exactly the same thing as 2048 (that is to say, TWENTYFORTYEIGHT means roughly nothing), but replacing 2048 with a symbolic constant that actually means something (say, BUFFER_SIZE) is a good idea.
Yeah, that's another post. This is just trying to get people to trust the app. Maintaining the trust is actually something else we've spent time on.
My App is much more stable on iOS 7.1
Why? Those are online resumes. Why they cannot be with pictures. These online resumes are for online presence. There is also print version of each resume.
Even in the most unstable areas of Egypt your personal risk if you take some obvious precautions is orders of magnitude less than continuing to have hepatitis C.
The drug does not "cost" $1,000/day. Rather, the manufacturer, Gilead, is selling it at that price in the US.

According to the article, Gilead is offering the same drug in Egypt "at a 99 percent discount to U.S. prices, or about $900 for a full course of treatment," and "wants to tier its pricing based on a country's per-capita income. So patients in the U.K would pay about $57,000 ...while Germans would pay $66,000 and Americans are paying $84,000."

Inevitably, a black market will develop for this drug, because the arbitrage opportunity is substantial. People who're willing to break the law will buy the drug in Egypt for north of $900 and sell it in the US for a lot less than $90,000.

--

PS. Even though the title of the article is linkbait, and the article itself has little content, I found it worth reading, because I learned something new: pharmaceutical companies are selling drugs in developing countries at a 99% discount (!) to developed-country prices. I knew prices were lower in developing countries, but not that low.
Caloric restriction is absolutely fascinating in all forms. I think intermittent fasting might be the best-known variant of this, but there are others. All of them cause dramatic changes in the way bodies function, from changing the hormones secreted to changing the form of fuel it uses to run itself (e.g. ketones in low-carb diets instead of glucose).

Caloric restriction has a whole bunch of knock-on effects, any one of which could have a huge impact on health and aging. For example, restricting calories means that you're restricting protein. Most people think of protein as a good thing, but that's what stimulates the hormone IGF-1 to be secreted, which is necessary for growth of all kinds--muscle growth (which is why bodybuilders eat as much protein as possible), but also including cancer.

I've seen research that suggests that cells don't go into "repair mode" in the presence of IGF-1. This is just one example of a possible mechanism that caloric restriction could have a hugely beneficial effect on aging and illness in general.

I have a half-written blog post about this I should push out. I'd love to get some more conversation going around this.
You wouldn't need to stay in Egypt for 90 days, you could just go and get a prescription, get it filled and come home.
I like that it's cheap but pretty much the bare minimum feature of a Japanese washlet is to let you set the temp of the water. Lots of places I've lived the water gets pretty cold especially in the winter. OW! ;)
I've been using IntelliJ IDEA for Scala for about a year. Best IDE ever.

With Scala IDE I've only had painful experiences, plus I hate Eclipse with a passion - but folks keep telling me that it got better. Well, I don't really care as long as IntelliJ IDEA exists.

They are also extremely fast and responsive in fixing bugs of any kind. I personally couldn't be happier and other communities can only dream about such IDE support. Of course, if you compare IDEA's Java support with the Scala plugin, it's worse, but IDEA works better for Scala than Eclipse does for Java, like seriously ;-)
The Law of One Price strikes again!
Oh right. Ok. I thought you meant CDs in general. I think it's been said now though that you get the rights to copy it if you buy this one.
I've used inDesign for my resume with --in my opinion-- great results.
The Cofounder Of 23andMe’s Next Project: Mining Your Quantified Self
IMHO i think that is more related to the platform(ruby) than rails itself.
Last year, 71 million people watched other people play video games
Photos on resume? Ain't your look not necessary to get a job in tech?
Try IntelliJ IDEA next time you play around with Scala.
Truecar.com is going public