skysight-inc/HackerNews huggingface dataset:
An interesting aside is that Gilead acquired the drug through the purchase of a small biotech company called Pharmasset. They purchased the company for $11 billion dollars and at the time, everyone in the industry though they were absolutely nuts for paying that much.

Total sales this year alone are projected at $5-8 billion.

[1]http://www.forbes.com/sites/matthewherper/2011/11/21/gilead-...
Obviously he isn't the intended audience of the book because he knows its thesis is false.
Basically, people are being asked to pay $90k to be cured of Hepatitis-C. About the same price as a Tesla Model-S Signature model. Is this an "unfair" price? I would argue that the value to someone of being cured of Hep-C is if anything greater than the value anyone could derive from driving around a new Tesla.
Except, I do believe, there are some countries (I want to say Argentina or Brazil) which do not recognize drug patents and will manufacture the drugs themselves.

Edit: India is another country that comes to mind.
IMHO, A website with a fresher and professional look never
hurts, better documentation, a nice and easy tutorial that show the core and fundamental features of the framework. Pretty much, i am describing you how Django started, except with the look of their website, even though is easy to navigate in it, that thing needs a revamp ;).
I'm in the exact same situation. I have a kid and a wife that take up the Lion's share of my time. As well as working at a PCI compliant company that forbids me from showing my best work to anyone else. It's a struggle and a challenge, but I've explained my situation and my frustrations to my wife and we try to carve out a few hours here and there and a few more over the weekends for me to build something that I'm able to show. We thought about quitting and dipping into our savings but for now it works and we can sustain this for a bit longer.

Good luck to you, and I hope that you will reach a resolution soon.
This Week in Tech (March 29-April 4, 2014)
Emu Makes Messaging Predictive
TV News: Search captions. Borrow broadcasts.
Done correctly, reviewing papers is a tedious, time consuming & utterly thankless job that takes time away from your own research. Papers also often go through 2 or three rounds of reviewing/revision. Each one of these cycles can take 1-2 months so it's not surprising it's a slow process.
My only question when I saw this: Why isn't this stock in my portfolio?
A 3 month vacation to Egypt isn't free. Even if you can live cheaply, you'll still likely have bills that you need to continue paying in the US.

I guess this could work if you can sever all financial ties to the US for 3 months and still have enough money to live in Egypt, pay for the medicine, then come back to the US and restart your life.
It may help to consider a wider context.

More than 95% of the world population lives outside of the USA. How do they feel about using the services of American companies and the NSA?
You can host the file yourself and name it anything you wish.
Wait till you see your BCBS fine print, that says the only approved hospital to treat Hep C is Cairo Medical Center.
What do we do? (Orkestra.co)
Buy you really buy that powerful and politically entrenched American corporation whose only purpose is tosell your info was "tricked" to sell your info when it's exactly what it exists to do for it's clients?
I think you can use mostly anything that will do proper text kerning and spacing. The rest is up to the person doing the design. InDesign is "the right tool for the job" (TM) but there is a learning curve.

This said, resumes are typically short enough that they really benefit from some hand-massaging of type and layout. LaTeX or other markup-based formats are good if your design skills are "can properly indent code" because they limit how much you can screw it up, but I don't see how you can produce a short, sweet and nice looking document with LaTeX without spending a week on it.
SMTP Listener – simple SMTP receiver
This is a cure, not a vaccine, so herd immunity does not apply. Once you get cured, you can get reinfected. Curing every person suffering from hepatitis C would reduce the potential for infections though.
Thanks, I will give this a try and retest!
Sounds like a good argument for nationalized health care to me.
Who does the Nest tell? It doesn't have any sort of social networking bullshit. The only way someone can find out if you are in or not is if someone gains access to your Nest account.

When you are at home is pretty obvious to Google anyway.
No, the basis for a reasonable fear is that he helped strip a civil right from gay people.

He has refused to speak about his views, so Mozilla employees and partners could reasonably fear that he might take other actions that harm gay people. Those need not be explicit and declared ones. Anybody who has been on the receiving end of bias knows that out-and-out bigots are rare these days; it's the subtle stuff that is more often the problem.
I would imagine caloric excess and celibacy tend to go hand in hand... so take your pick
Can you provide more info about this? That medical researchers are actively avoiding looking for cures for diseases? It just screams "baseless conspiracy theory" to me. And what do antibiotics have to do with it? As far as I know, antibiotic resistant bacteria are the result of factory farms pumping animals full of antibiotics, and patients simply not completing the full course of drugs once they feel better.
I dislike the use of a parser generator libary. If it were any other language, sure. But Lisp is so easy to parse. Writing parsers is fun, and it would be a good exercise. I applaud you for wanting to teach beginners how to install libraries, but this seems like the wrong choice.

Props for mentioning conditional compilation early. It's underrepresented in books but essential for real life.
In C and C-derived languages, the C preprocessor can do some work on its own before anything ever hits the compiler. You can put a block of code like:

#ifdef DEBUG
if (pw == "backdoor")
return true;
#endif

And then when you want to have your backdoor active, just #define DEBUG somewhere upstream. That way, the backdoor code will never even be compiled in a non-debug program.
While I fully agree, there are people who actively sabotage their success, like drug abusers.
Bitcoin Job Fair
The counterargument should be obvious -- peer reviewers are often unpaid experts who review pending articles in whatever spare time they happen to have, between delivering lectures, research, and applying for grants. To speed up the process woulds be to increase its cost, possibly very much, or to degrade the peer review process.

The defects of another alternative should also be obvious -- paid peer reviewers. If this change took place, people would line up for positions they aren't qualified for on the simple ground that they can get paid to appear to be what they aren't. Also, for many cutting-edge fields, there simply aren't more than a handful of qualified reviewers at any price.
It affects mutual fund managers who many joe sixpack types do have a stake in.
Actually if you Google Image "Resume" most do have an image.
Best Children's Picture Book is Freddy Fudgesicle
Freddy Fudgsicle in Friends Forever is the best children's picture book of 2014. This book will help your child learn how to make new friends today.
I feel it's naive of you to think that. It seems apparent that he was forced out, the fact that he was allowed to resign is just because this whole situation is ridiculous.

I'm not going to go into why I feel that way because there's an entire thread elsewhere that hashes out every single possible approach numerous times.
> What are the chance sone anonymous kid will cut your fire alarm just for giggles? Pretty high

I guess that's where we disagree; I would have said, "Less than the chances of getting hit by a bus on the way to work."
Two other concepts you really want to understand before forming an opinion about HFT: "large block trades" and "bid-ask spread".

Lewis has a drive-by mention of bid-ask spreads in the book (he concedes that they've been decimated, while asserting without evidence that HFT has created a new "shadow spread"), and, thus far, no mention whatsoever of the mechanics of large-block trades. In Lewis' universe, a hedge fund can unload 100,000 shares of XYZ just as easily as you can sell 10 shares of AAPL.
Car-To-Car Warning System Set For America’s Roads
UT99 has been playable on Linux since like forever.
Depends on the language/compiler/linker/preprocessor/interpreter/etc.

I'm not really a C developer, but since it's a lingua franca, GCC lets you pass in -D (name), which will define that passed in as a macro, letting you do stuff like

#ifdef DEBUG
//Do debug stuff
#endif

so that if you run gcc with -DDEBUG, you will have DEBUG defined and set to 1 (you can also do DEBUG=val and similar I believe), and if you don't, it will be removed.

Java, I don't believe javac has a similar compiler mechanism; you either need a hardcoded global value in the source code

public static final boolean DEBUG = true;

and you can do similar

if DEBUG { (...) }

and then for your prod compile you set DEBUG to false and recompile everything; or, you can swap out implementations of a particular class, and have everything code to the interface (all that typical Java IoC dependency injection joy).

For any other language, consult your documentation. If there's nothing else, and the language allows you to pass in arguments into the runtime executable, you could always do something really ungainly like accept an argument for 'environment', and have code that executes differently based on that. It's a minimal cost (since any given run will lead to that particular switch always executing the same way, I'd wager your CPUs branch prediction is going to effectively make it free, but even if it doesn't, it's minimal impact), and it lets you execute the code differently based on what environment you specify you're in.
All the Atypon clients seem to have now disabled this trap (I tried the 5 biggest ones).
Beware TOS violations (read comments)

http://www.quicksprout.com/2014/02/19/how-to-steal-your-comp...
Redsgned v2 Launched
Tower of Babel in our lifetimes
On the other hand age related diseases like diabetes have some pretty unpleasant symptoms, if you could avoid them just by adjusting your diet in later years it's worth knowing about.
For years we've heard the charge that pharmaceutical companies are little more than parasites creating perpetual users of their drugs rather than curing anything.

It's worth noting that this drug company is curing something significant and the fact that they're trying to make a go of a business out of it is a bad thing?
Picture on resume is not mandatory. Users always can just to leave picture field blank and on resume it will shows default dummy/universal photo for all genders.
We shouldn't conflate 'access to basic healthcare' with providing 'all forms of treatment without regard to cost'. More progress could probably be made if we were discussing a less emotionally charged example though. Consider eyeglasses vs. contacts for instance; much easier to work through the issue there.
It might also work if the audition was applicable to many potential employers, like how talent scouts in sports and the arts go to events where the potential talent performs rather than having the person audition for each potential employer. (I'm not an expert on arts or sports so I might be off on my analogy.)

I hear a lot about GitHub, blogs, and open source contributions which essentially act as your audition open to all talent scouts.

Perhaps if the audition challenge could be posted to the applicant's GitHub account then it would be a bit more useful to the applicant. The challenge could be skipped if a project in the GitHub account already demonstrates proficiency in the desired application domains.
There is a real and meaningful difference between popularizing and fictionalizing though. Some amount of gloss is needed to keep things tidy but if/when that crosses the line then the author is doing a disservice to his audience. This is doubly bad when the book in question is an indictment of the status quo with what amounts to a "call to action" in favor of some new business venture.

If the book was presented as non-fiction "based on a true story" that's one thing, but If the b
Sports to keep yourself at shape. Doesn't really matter which sport as long as it's fun for you. I particulary like swimming, running and badminton.

Cooking. You can easily make great meals from raw ingredients so you are not dependent on local restaurants or anything, just have a stock of long lasting base ingrediences and if you eg. run out of bread on holidays, just make your own. Besides that, it's another topic you can use at chit chat; it's attractive to the females and you can save some money.

Learning physics. Well, that's just cool and maybe you can find some practical use too, once you learn enough. The freely available Feynman lectures are great.

Playing an instrument. I try to learn ukulele and even though I totaly suck, even trying broadened my horizons and perception of music.

Reading beletry. Whatever floats your boat. I like scifi and some classics Sherlock Holmes or Three Men in a Boat.

Reading scientific studies. Whatever catches your fancy. Eg. I recently read about reviewing effectivity of methods law enforcement uses to spot drug users or how different music affects customer at shopping mall.
Please don't start this again, if you want to have a flame war go to reddit or 4chan.
There is free shared DB service + in a few weeks a new DbaaS for dedicated instances
This is vaguely interesting I suppose, but while 123/21243 (click through rate) is significant, 61/92 (lost clicks) is not.

...and therefore every single derived stat is completely nonsense. A percentage you say, on a sample size < 100?

Whats your confidence level on that?

(I also think that Facebook ads are a waste, and the conclusion is plausible; but the stats in the post are meaningless and probably deceptive)
Is the anecdote really unintentionally ridiculous? Lewis acknowledges SAC's later infamy in a parenthetical (quotation below). And the point of the anecdote is that even a party that went to great (and illegal) lengths to gain an informational edge didn't understand the new phenomenon of latency arbitrage by the HFTs.

Quotation: "He had a good friend who traded stocks at a big-time hedge fund in Greenwhich, Connecticut, called SAC Capital. SAC Capital was famous (AND SOON TO BE INFAMOUS) for being one step ahead of the U.S. stock market. If anyone was going to know something about the market that Brad didn't know, he figured, it would be them."
> What is the driver of false clicks on FB?

Facebook's reputation as en effective advertiser is improved. As Deep Throat said during the Watergate scandal, "Follow the money."
Pardon my ignorance but what context of startup is acceptable? Apps and services or blogs, forums and other social engagement sites.

I am genuinely curious
Something like Lipitor people take forever, so its use will grow over time. This drug cures people, who no longer continue to take it. There must be a big backlog of people with hepatitis C. Once you go through those people, I would expect that the use of the drug will decline, to just be people just contracting the disease.
Reddit user writes SQL primer for /r/iwanttolearn
Ditto. In fact, my psychiatrists have loved generics, they don't want cost to get in the way of treatment.

(Caveat: generic mood stabilizers (used for treating bipolar disorder) that are also anticonvulsants have I've heard a bad history of not working like the brand name, First World manufactured originals.)
Because you're confident that with that system and its incentives this drug would have been invented? As well as the ones which haven't been invented yet?
> government-backed insurance

Can you therefore explain the cost of health-care in the UK on the National Health Service?
Looks really nice! Would be great to be able to connect with LinkedIn for example, to save time filling in job details/dates etc.
Brazil specifically invalidated Merck's HIV drug patent.

http://www.ft.com/cms/s/2/c7d3f1f4-fa78-11db-8bd0-000b5df106...
Solvadi/sofosbuvir was discovered by Pharmasset, Schinazi and Liotta's lab, which Gilead picked up for a cool $11 billion a few years ago. I believe sofosbuvir was Pharmasset's main IP (I think they had some HIV treatments -- S&I's wheelhouse from their time at Emory -- in the investigational stage, but Hep C was their big product.)

There are a couple of things to consider about this. The first is that there are a lot of HCV treatments expected to come online over the next few years, so Gilead has an incentive to jack up the price now while they're the only game in town -- and with $11b in acquisition costs, they need to make their nut back on this.

Second, only a very small number of HCV patients are in high-income countries. 6.4% of all HCV victims are in US, EU and Japan, but Egypt alone has up to three times as many HCV patients as the US. (Anyone wanting to go to Egypt for cheap HCV therapy might think twice; poor infection control practices in Egypt's health care system has been implicated as the primary source of HCV infection.)

With HCV raging through so many poor countries, it's reasonable to at least discuss subsidizing global access to medications by increasing the rate paid for treatment courses in wealthy countries. The alternative would be direct financial support of global access which, given the current political climate in developed nations, is unlikely to get much traction.

I'm certainly not saying that Gilead is operating with humanity's best interests in mind -- few industries are as brutally venal as pharm -- but it seems to me that the tradeoff is something that is at least worth discussing.
Brendan Eich gave $1000 to support the following text to be amended to the CA constitution:

Sec. 7.5. Only marriage between a man and a woman is valid or recognized in California.

You take that to mean he supported this being amended to the constitution:

Gay people are inferior and not deserving of full civil rights.

Which is a wonderfully built straw man, but not at all likely to be an idea that Eich would ever espouse. I don't know Eich, but his public record doesn't seem to support the supposition that he thinks anyone is inferior or that anyone should be denied civil rights.

If you really want to attack his ideas, attack their best interpretation, not their worst.
Ask HN: Wage fixing. Any updates from the trenches? 
Are Googlers getting calls from Apple and vice versa? My selfish interest in asking this question is that I'm relocating from Denver to work for a startup in Sunnyvale. Home prices are through the roof. If wages are going up, I'm guessing the housing situation is only going to get worse.
Eich expressed sorrow for causing pain to his colleagues. But he did not apologize for working to strip gay people of a civil right. He did not say he thought that was wrong. He did promise to be a good boy at work, which is great, but I can understand why some people find that insufficient.

Personally, I'm not trying to crucify anybody. As I wrote in a number of places, including the very post you reply to, I don't think the donation should necessarily have been a problem. We all make mistakes. But his handling of this has been terrible.
-JFK -> CAI April 30 $498

-CAI --> JFK July 31 $661

-Lonely Planet says you can get food and lodging for $20/day (x90 days = $1800)

-Cost of treatment $900.

Total of $3859 vs $84 000.

Might just work ;)
I think "shilling for the buyside" is a bit strong. Lewis aggressively pursued a compelling and simple narrative in a market that doesnt have an easy story. I get the impression he didnt even recognize that the field he decided to plow was a minefield. The HFT debate is complicated and has serious implications: his treatment didn't respect it.

From acquaintances that knew Katsuyama personally, he was described as a genius marketer, not a technologist. Before even Lewis came along, he had crafted a large part of this narrative: the Thor matching technology succeeded on a compelling story. Lewis got sucked in.

The personal reactions you may have seen (William O'Brian on CNBC) are authentic: HFT participants (and those who deal with them) have been villified in an industry already viewed in a negative light. There are some bad apples, but there are also many who genuinely believe that they are doing a service for the market.

I don't blame Lewis for this. I just hope that there is an author that can create a compelling story that doesnt fall for the tired trope of the evil HFT trader. The story exists - it is just very technical and nuanced at times. Unfortunately, many HFT participants have been shamed away from standing for what they believe in so there are very few left to tell the story.

If you want to read a rebuttal and learn more about the markets at the same time, check out this analysis by Larry Tabb - a market research consultant prominent in the US execution technology market:
http://www.scribd.com/doc/215693938/No-Michael-Lewis
Let me rephrase:

For much of history, civilizations and other groups of people took conquered peoples as slaves to support the conquerors' lifestyles. The slaves served as the cheap energy that today has been supplanted by fossil fuels.

Our Western lifestyle is predicated upon these fossil fuels in much the same way that prior societies' lifestyles were based upon slavery. Slavery has undesirable characteristics that we (being dependent on it no longer) are free to scorn the evils of.

Fossil fuels also have undesirable characteristics: they're polluting the atmosphere, polluting the water, and releasing boatloads of greenhouse gases into the atmosphere. Sea levels are rising, coral are dying, and storms are projected to continue increasing in magnitude. Perhaps you've heard the economics saying, "There's no such thing as a free lunch."

You and I are so utterly dependent on this source of energy that our brains can't fully comprehend the consequences of choosing the alternative. And there's absolutely nothing we can do to convince anyone else to stop using fossil fuels. If you're anything like me (and other normal humans), you ignore the costs associated with your actions and continue to use fossil fuels for transport, for food, and for electricity to power your electronic gadgets. To change your lifestyle would require severe unpleasantness.

*edit for clarity
I could say the same thing for for-profit drug discovery.
Ukraine to Get Its Own Social Network – Once the DDoS Attacks Stop
I found his interviews really compelling and thought about getting the book. But I had this nagging thought the whole time -- you know, I've been hearing about HFT for years, could it really be some super-secret cabal? The linked article does itself no favors with its pissy tone. I almost didn't read through it, but I'm glad I did, because I learned quite a bit. As always, the truth is somewhere in the middle.

Michael Lewis is a master of taking something complicated and turning it into a clever narrative. However, this narrative is simpler than, say, Moneyball: bad guys are "stealing" from good guys, there's a detective story about figuring out how it's happening, and there's a build-a-better-mousetrap montage at the end. It's too perfect. Odds are there's a screenwriter crunching this sucker down into three acts right at this moment.
That "Coming Soon" page can often provide more ideas and interesting discussion than the billion dollar business.
You'd need to take a sabbatical from your work in the US, rent an apartment in Egypt, and continue to pay bills in the US.

But given that by doing so you'd be saving $83,000, that still sounds like a pretty good deal to me. I'd imagine you can live pretty nicely in Egypt for a lot less than $27,666 per month...
Linux-Kernel Archive: Re: [RFC PATCH] cmdline: Hide "debug" from /proc/cmdline
The direction others are taking with this is great, but I'm really interested in adding tons of sensors.

We can finally build the tricorder the world deserves : )