skysight-inc/HackerNews huggingface dataset:
The KKK is in fact a legal political cause.

Regarding the FFR, I'd say no, because as far as I know they aren't trying to strip a civil right from somebody. But suppose we were in one of the eras of American history where Catholics were seen as deeply suspicious by Protestants. If a protestant CEO had helped strip Catholics of, say, civil recognition of Catholic marriages, then yes, I would say that Catholics could be reasonably concerned about working for him. Even if he pinkie-swore to keep his anti-papist rants entirely out of the office.
Right now our political culture can be described, for instance, as "Money is speech." Changing that would be tectonic.

It's not our systems of governance that this would necessarily change; it's our political culture.
http://www.truecar.com/S1/
That depends how attractive you are I suppose.
What is the driver of false clicks on FB? So far as I know it isn't like Google where a third party will be paid something for the click. Isn't FB the only one getting paid when I click a FB ad?
Just in case someone else thinks of doing this; it's totally against the Facebook Ad Guidelines

There's other ways of doing exactly that which maintain user privacy and are within the guidelines though.
Well, I recommend in general getting this book: http://www.amazon.com/Feeling-Good-The-Mood-Therapy/dp/03808... (the good basic, for "patients" vs. doctors book on cognitive therapy (now cognitive-behavioral therapy, but I read it before that addition), and take the Burns Depression Checklist at the beginning of chapter 2. Based on your score, you'll get a rough idea from "no depression", "normal but unhappy", then "mild depression" all the way to "extreme depression". Based on that you can then know appropriate steps to take.

I'd add that I'll bet anyone can benefit from going through their thought patterns applying the insights of congnitive psychology, the therapy side of which says, very roughly, one way to make yourself depressed is to think incorrect bad thoughts about yourself (which includes how you view other people viewing you, etc.).

(Which is not to say there aren't also pure biological causes (see tokenadult's excellent comment: https://news.ycombinator.com/item?id=7530847), family history eventually revealed that's a factor in my particular type of depression, but it's certain that self-applied cognitive therapy from an earlier edition of this book made a big difference for me, it's just not enough.)
Or you'd hate to have been hungry for most of your adult life in order to live two years longer, and still miss the rapture.
Do you write it in Scrivener too? Or just use it as a notebook and then write it up in another text editor?
If you look better, you can see that picture are not mandatory.
The World in 2035
This was a great article. I started reading the book. Early on, one of the examples given was "Brad talked to a friend of his at SAC Capital" about how HFT firms were taking advantage of information in the markets.

That is the kind of unintentionally ridiculous anecdote which undermines the moral center of this book. SAC Capital, after all, is the same fund which ran into one of the largest insider trading cases in history, which is also about taking advantage of information in a, let's say, special kind of way.

I know a lot about this subject, probably too much to let the judgment fall cleanly in one camp or another on HFT, but with all the hubub right now, I find it might be useful to get biblical for a second - let the person who is without sin cast the first stone.
Loads.

You could book into one of the tourist resorts for far less than $1000 a day.

I took a quick look at Expedia, You can book the Cairo Marriot for a full month for $3200 ~$5300 multiple that out for 3 months and double for other expenses (flights, visa etc) and it's still a third the price.

Craz
>Received 12 October 2013 Accepted 05 March 2014 Published 01 April 2014

Am I the only one who finds this crazy? It takes 6 months from submission date till publication!

The peer review process should move faster and become modernized. I undrestand, you want to be published on prestigious journals, but Nature and others can modernize to publish more. You can argue, we lost 6 months or half a year of progress because of the pace of antiquated publication process.
In short:

Internal API = OData (= data layer)

External API = WebAPI with OData methods (=service layer, which brings the endpoint data to 3rd parties)

And because it's an internal API, it's a reason why you don't see it a lot in public API's (SAP uses it intensively though)

Thanks :)
I'm sure a black market will develop, but it will be pretty limited as the FDA bans the importation of pharmaceuticals unless they have already been approved for import.

However, I've read that purchasing a 3 month supply for personal use is allowed, so maybe it will turn out to be something big?

However, from what I've read, drug manufacturers but strict limits on drugs produced in low income countries. If there are 500K patients with HCV, the drug companies is going to put a quota on how much is sold. If Westerners start importing it, then that means Egyptians will go without.
It seems this guy isn't the intended audience for the book. I, for instance, know that Netflix performance is bad on certain ISPs because of throttling and peering agreements but if someone wrote a narrative about this I wouldn't berate them for telling the public at large about it in words they would understand.
Two powerful quotes:

>More than half of those with hepatitis C are veterans, prisoners, uninsured or on Medicaid, the New York Times reports. That requires taxpayers to pick up the bill.

>It doesn't help that Gilead is offering Sovaldi in Egypt at a 99 percent discount to U.S. prices, or about $900 for a full course of treatment.

Tiered pricing by country (from a US company, no less).

I'm not sure what to think about this - very complicated ethics. I can sympathize with both sides.
I had to make a QQ account while I was studying abroad in Japan to play League of Legends. Needless to say I need to brush up on my mandarin.
I assume when you say SSRE you are talking about tianeptine? Its affinity for SERT is low and its primary target is believed to be elsewhere.
I would say ONE_TB is an improvement over 1099511627776 when it comes to "natural to reason about" numbers, but yes, defining ZERO and ONE is moronic.
That Seattle kid who fought an octopus on its turf, bare handed, probably counts though.
Loved them. Thanks for sharing the link.
Contrllr Unveil
My new side-project Contrllr is coming along smoothly, and I'm looking for critique and feedback on the homepage that I've done. This is a first stab at the design, and would welcome any feedback on the layout, colours, imagery etc.

Contrllr will be a community very similar to how Letterboxd have set their site up, but focused on games instead. There's plenty of gaming sites out there, where the final site is a mix of all things. Contrllr plans to be a site where you can review games, makes lists, share your game progress, import from XBL, PSN and Steam for achievements and game lists, and more.

Link to Dribbble shot: http://dribbble.com/shots/1494536-Contrllr-Homepage
You don't have to be a security researcher to type stuff into a password box and try it out. It doesn't seem so far-fetched to me.
That's kind of the idea. If you give someone a patent monopoly, the expectation is that they'll charge monopoly prices. The monopoly price is the price at which the product is only just more attractive than the next best alternative.

The actual problem here is not the price of the drug, it's that you have an expensive cure for a widespread disease which becomes available all at once. So instead of insurers paying for interferon and liver transplants over the course of 50 years, you have every patient in the country handing a $90,000 tab to the insurance company at the same time. Even if the total cost is lower over 50 years, the insurance companies may not have the reserves to handle such a large hit in year zero.

But the underlying problem is this:

> Gilead wants to tier its pricing based on a country's per-capita income. So patients in the U.K would pay about $57,000, Reuters reports, while Germans would pay $66,000 and Americans are paying $84,000.

That is why the American healthcare system is falling apart. That alone, by itself. Because it happens with everything from drugs to MRI machines to heart monitors. We pay twice as much as the next country for exactly the same product and then people are like, why is medicine in this country so expensive? It's because we don't have laws against that sort of naked price discrimination, that's why.
Part of the problem is that "smart" people, especially technical and scientific people, refuse to believe that prices aren't based on logic and hard facts, but the circular-definition that is markets -- the price is what it is, because people pay it.

Let's call it the "religion of tangible explanations." People refusing the more correct although ambiguous explanations, in favor of the BS explanations, just because they have a bunch of tangible logic and reasoning attached to it that makes you feel better.
You forgot, "how many years do they have until the patents run out?".

I know of one drug that was running 5 figures a day in clinical trial costs. You need to charge to pay for the drug.
This is really a cultural issue. In the US, pictures are a big no-no but in my experience with LATAM and European companies, pictures are common if not expected.

Design wise, the picture is a good opportunity for visual appeal.
Even if it is not lies. I have seen several legitimate cases:

1. The agent reformat you resume in a common standard.

2. The agent add a custom section with the result of their "screening" and other client specific requests.

3. The HR of the client needs .doc

4. Client want to receive a single file with everything for a single candidate.

Agent is a shitty job. Sure when you place a candidate, there is a huge payday, but you still need to get through a lot of boasting candidates and clueless customers for which you will make no money at all. Also most companies would not be able to recognize that a candidate that is like Linus for a linux kernel job.

edit: not defending them. But I have some sympathy - they hear me whining about a company giving me an extra 5K a year when I make 4 times more than them.
However, drug companies spend more on advertising than research which should give you some ideas for savings.

Right. Because all they have to do is offer the drug in an app store and the world will beat a path to their door.
Intermittent fasting is the smart way to restrict calories whilst still enjoying food.
Ask HN: Should I cash out my 401K and try to get my dream job?
I'm a professional and conscientious engineer who loves developing software. I've been doing this for 13 years.
I've worked for a few small software companies, working on commercial software. I know I'm a great developer, but I think the fact that:

* I don't have a GitHub profile,
* have not contributed to any OSS projects,
* don't answer a ton of question on StackOverflow,
* cannot share any of the code I've worked on
* and so forth,

...are not helping in the search for my dream job. These are the things that seem to get people to show interest in a developer these days.

I have no time, (or I'm not allowed), to do any of these things while working full-time for an old-school software company. I'm considering cashing out my 401K to live on for the next 6 months and spending all of my time working on these types of things to make myself a more attractive candidate. This would really make me happy, but is quite a gamble given that I have a family.

Thoughts? Has anyone here done something like this?
Egypt deports man lobbying against mass death sentences
Show HN:collaborative real-time text-editor in just 1 php-file
Many companies spend more on advertising than product development.
The market is absolutely huge. From what I've seen so far, this drug is expected to get revenues of $5-8B in the first year.

That is an absolutely incredible number when you consider the best selling drug ever, Lipitor, had total sales of $11B in it's peak year.
Agreed, and as a mechanical solution, it is likely better than an electronic solution in a damp environment such as a shower.
I suspect first we'll have something that looks more like Elysium and then something that looks more like Star Trek.

I doubt we'll ever have either extreme (and different parts of the world will likely have different bits at different times).

Certainly going to be an interesting 100 years (but when has that ever not been true..).
If you want to join a well-funded, stealth effort aimed at completely solving human biology in your lifetime, and you also happen to be an extremely talented software engineer, send me an email and say hi.
Kent Kemmish
kemmishtree@gmail.com
www.linkedin.com/in/kemmishtree
For clarity: my dream job is one that has a great culture,
interesting work, is making money, and is remote friendly.
Is even that necessary? I bet you can buy the drug without a prescription in Egypt, on the black market. Then just set up shop in international waters, off the US coast.
The way I (as a lay person) read this is:

One side: "HFT hurts the little guy and helps billionaires! Boo HFT!"

The other side: "HFT helps the little guy and hurts billionaires! Yea HTF!"

Reality: "HFT is pretty much irrelevant to the little guy. It helps some billionaires and hurts other billionaires, and this is only a story because billionaires are all talking about it."
Please tell me this is a parody. Please.
Erik DeBenedictis on supercomputing
> Guido works at Dropbox. I am sure he is advising

Guido worked at Google during Unladen Swallow, he was not involved. From the comments of Pyston's announcements, here's the extent of GvR's involvement:

> Guido's advice has been extremely helpful, but so far we haven't been able to get any code from him :/
The publicity materials for this recent set of results do a good job of explaining why the researchers think that the NIA study is flawed. In essence the NIA control monkeys are probably on CR.

http://www.newswise.com/articles/monkey-caloric-restriction-...

“In Wisconsin, we started with adults. We knew how much food they wanted to eat, and we based our experimental diet on a 30 percent reduction in calories from that point.” In contrast, the NIA monkeys were fed according to a standardized food intake chart designed by the National Academy of Science.

Through their own experience in monkey research, and by reference to an online database recording the weight of thousands of research monkeys, the Wisconsin researchers concluded that the NIA controls were actually on caloric restriction as well, says Colman. “At all the time points that have been published by NIA, their control monkeys weigh less than ours, and in most cases, significantly so.”

Weindruch also points to some results from the NIA that seem to contradict the “no significant result” analysis. Twenty monkeys entered the NIA study as mature adults, 10 in the test group and 10 in the control group, and five of these (four test monkeys and one control monkey) lived at least 40 years. “Heretofore, there was never a monkey that we are aware of that was reported to live beyond 40 years,” Weindruch says. “Hence, the conclusion that caloric restriction is ineffective in their study does not make sense to me and my colleagues.”
If you scroll down to the bottom where it says "Trending Now" all of the headlines (including this one) state 10news.com KGTV ABC San Diego.
Blagh. I want to be mad at imgur for this behavior, but I can't bring myself to.

Is it really bad to show people, once, what site they're being linked to? The whole "no ads, direct links" has always been framed as a thing imgur does to be nice, and in return reddit likes them. Does it matter if people who've never been to imgur before see the site once instead of a direct link?
Even for average guys, the picture is a welcome visual element in resumes. US-centric resumes tend to be very wall-of-texty because of the "ALL RESUMES SHOULD BE X PAGES LONG" (X in {1,2}) policy forbidding the use of "wasteful" whitespace.
In North America I would say that is discouraged from including a photo on your resume, so I would not go with that option here.

I've heard (and read [1]) that in certain European and Asian countries it's customary to include a photo with a resume, so perhaps that's why the option was provided.

1. http://www.expatarrivals.com/article/how-resumes-differ-from...
You could be correct that only legit users clicked the FB ads and upon review of my site they had no interest in using my service or my pricing scared them away (or any other legit number of reasons).

However, it would be willful blindness to ignore what I can verify vis-a-vis the FB paid promotion. Moreover, when I can verify the majority of likes are from illegitimate users/profiles, based on not having any posts and otherwise being inactive, then I have no expectation the users clicking the ads are any more legit than users clicking the promotion. If FB had faith this was not the case I see no reason they would not disclose the users who clicked the ads so advertisers could confirm their legitimacy.
Releasing Mochi (webOS design language)
Yes, assuming everyone prices everything perfectly rationally and knows what they are buying. I expect a good deal of Facebook expenditure is people trying make it work for them, and assuming they are doing it wrong. In the long run perhaps the price will reflect a lower value.
PlanBCD: crowdsourced growth optimizations
It's a PR line because everyone wants mechanism explanations, and the truth, "If we poke at people's brains with sticks shaped in these ways, their mood improves" is unpalatable.

That "sticks shaped these ways" happen to affect neurotransmitter levels is a great guide to finding others, especially the great moves in safety from MAO inhibitors -> trycyclics and the like -> 3rd generation started with Prozac, is sort of besides the point. That they make a really significant difference for lots of people is.
An open source ethos in pharmaceuticals would pretty much guarantee you'd have a lot fewer new drugs developed. If it costs $500M-$1B to develop a drug, how on earth do you raise that money if some random company can come by and sell the same drug for $5/day because they didn't pay any development costs?
JFBmarketing at APSense: Windows of Opportunities with Gold, could this be true?
sillysaurus3 said "a clever programmer will always be able to boost performance more than a compiler." That's a much, much stronger claim than the mostly unobjectionable "a clever programmer can still typically boost performance more than a compiler (especially when they have the ability to look at the output of that compiler with various optimization settings)".
Show HN: Eventify – Quickly publish your conference website.
Largely depends what you're selling. For example, I have a client in the travel industry--their ads kill on FB.
As far as I know, no recent court has found that there is a rational basis for anti-gay-marriage laws. The Nebraska decision hauled up a 1972 decision, back before much of the science was in. And the entire point of Prop 8 in specific was to strip a right from gay people by amending the CA State Constitution, so I'm going to stand by my assertion that marriage redefinition is not what's going on here. Indeed, it's Prop 8 that explicitly redefined marriage here.
I wonder if they would adjust their pricing (and which way) if Congress threatened to shorten the life of patents, perhaps particularly on "drugs".
I at least appreciate the fact that Gilead produced a cure, rather than just a treatment. Medical research has taken a frightening turn in the last decade towards working on treatments that patients will have to take (and pay for) the rest of their life, rather than cures. Already, we're looking at a potential drug-resistant bacteria epidemic thanks largely to the fact that antibiotics are just taken a few weeks at a time. So, at least they're charging $90k to cure Hep C, rather than taking $10 out of your pocket every day for the rest of your life?
According to the article most recipients of the drug don't pay for themselves so I think few would be incentivized by the savings. I am sure there are suitable places in egypt though.
Well, for such a huge monetary difference, patients could fly to Egypt or Africa for three months of treatment. That should be 100% legal.

But nowadays with no preexisting condition clauses, just sign up at healthcare.gov and away you go...
This line of thinking is juvenile. He was being singled out as the CEO of Mozilla.
It can be as simple as:

#ifdef DEBUG
... code ...
#endif
Just have to wait for India to copy it, then visit India for medical tourism. They are one of the few countries standing up against big pharmaceuticals when important medicine is priced out of the reach of average citizens.
The language was fine... Just saying I've never heard of the one you say is most promising regarding adoption numbers
I can't see how the DB services are priced. Do you need an extra host for the DB?
Front page of HN = OSS promotion complete. :-)
Another way to look at the huge price tag to cure 90% ($227 billion) is that this would could eventually give us herd immunity. We could then treat this at a lower cost per year going forward. That thought is mind boggling.

While the cost is high in the USA the drug company is basically subsidizing their own distribution to other countries based on the GDP of the buyer. WOW, honestly that sounds like a pretty darn awesome thing to me. That $1000 price tag on those drugs is similar to a $10 price tag per day on other drugs to people in other countries where they make $1 per day. It just makes this drug more attainable for everyone and if that is Actually what they are doing I applaud them.

Sure I don't want to pay $1000 per day for this drug, but is it ok for us to drive the cost down relative to our cost of living and make it prohibitively expensive for others?

This is also what they did with some of the better drugs for curing MDR TB. I only know that because of the book Mountains Beyond Mountains. Where the better drugs were nearly unattainable for the poorer countries.
Yep, if you Google "Philippine Resume", you can really tell that pictures in a resume is the norm there.
You need to advertising since you have such a short window to get back your research money. Look at this article from 2011 about having to defend high R&D budgets: http://www.reuters.com/article/2011/12/13/us-merck-idUSTRE7B...
Many of the world's best engineers don't have a Github / OSS contributions / Stack overflow / etc. They're still quite hireable. It is highly likely you are also hireable, even without a portfolio that you can conveniently point to, although that would be an asset.

Do not cash out your retirement account. [Edit: Generic personal finance advice for everyone: Unless your children will starve in the snow otherwise, it is never a good time to cash out your retirement account. It will be very tempting to tap it to pay for your wedding, your first home, a medical emergency, your kids' college, etc etc, but if you do this, you will not have it at retirement. This is far and away the largest risk associated with self-directed retirement accounts.] It is not required to buy coffee for people with the ability to hire engineers. Coffee is cheap and jobs are plentiful in the current environment.
I meant CS puzzles (like in programming olympiads), which are still widely used I believe.
Perhaps it's just because I've never seen a good implementation of a bypass, and I might agree if I had seen one. Like many things, maybe it just takes the right people to make it successful.

Postgres leaves a lot of performance on the table in much more basic ways, too, so I certainly am not suggesting that postgres is anywhere near optimal.