skysight-inc/HackerNews huggingface dataset:
It isn't actually a "lack of understanding" - I was doing research into phage therapy over a decade ago, and the field has progressed since then.

There are however a number of problems with phage therapy, and this is from the perspective of someone who likes phage therapy:

- Phages are usually very bacteria specific, there isn't really a "broad spectrum" phage. The therapy used in Russia and Georgia is often a bespoke formulation for each individual patient. This is:

a. Really, really hard for the FDA to approve.
b. Expensive as all hell.
c. Involves keeping "banks" of phages around, and creating custom cocktails of them. This is, as mentioned, expensive as hell, and manpower intensive.

- Phage therapy is fairly novel in the West, due to some problems in the early days of phage therapy followed swiftly by the discovery of penicillin. It's an entirely different method of treatment, which means all the clinical knowledge doctors currently have is invalid, and has to be relearned. That's tough.

- There's no promise a bacteria has a phage associated with it, and synthetic phages are, at this point, a pretty distant prospect.

- When bacterial cell walls rupture, they create endotoxins. Endotoxins are bad - indeed, in the early experiments with phage therapy in the West, insufficiently pure phage solutions with endotoxins in them were responsible for some deaths. Right now, phage therapy is most often used in dire cases, where side effects like that are less of a thing. For a bad case of Strep throat? There's some serious clinical trials that need to be done.

- It's a hell of a lot harder to give someone a 14 day course of bacteriophages to take home than it is a 14 day course of antibiotics.

Phage therapy is a really fascinating field, and I think it has a lot of potential. But to say we shun them due to a lack of understanding, or acting like what the Russians and Georgians do is "utter sorcery" ignores a great deal of the research that takes place here. The real problem is, even while we struggle with resistance, antibiotics are profoundly superior as a general purpose drug. The reasons the Russians used them so heavily is because they had trouble getting antibiotics.

But seriously, "What about phages?" isn't exactly a new idea.
http://macaw.co looks promising.
ComputerCraft has the turtle[1][2] which allows you to program it using lua.

[1]: http://computercraft.info/wiki/Turtle

[2]: http://computercraft.info/wiki/Turtle_(API)
I liked the sound of leetcode, but I see the way to answer is with code (C++/Java) instead of a value answer. That ruins it for me.

I want to play with new programming languages, and see if the output is correct while I'm at it.
On your mac you can use alt+shift+dim to get 4ths of the normal box.
You've renamed everything as cat. But the problem remains the same.
USA marketing must be top-notch, if smart people are willing to give up all that to come here.
Show HN: A scalable web automation API for developers
This is always a canonical example for Erlang. For example the game servers for Call of Duty rely on Erlang.
http://www.slideshare.net/eonblast/an-erlang-game-stack
Accounting for inflation despite the budget remaining approximately the same (within terms of 100 millions dollars), its still declining by nearly a billion a year due to inflation.
I wish I could work with people with your mindset. Have you considered writing on the subject? There are so many people that could benefit from your experience.
[iOS Tutorial] Interactive Transitions
There are three uses of antibiotics in veterinary settings:

1. Treating actually sick animals
2. Low-dose treatments to promote growth
3. Prophylactic treatment to prevent initial infection

Both 2 and 3 are widespread, and a problem.
1) the project != why it's done
2) the project != you personally or your work or why you do it

> It's interesting you think that i just do whatever i'm told to do

That's how jobs work, is it not? You get tasks/responsibilities assigned to you in exchange for a salary. Doing your job doesn't mean you're being evil, even if Google or its management is. I see why/how you got upset, but I didn't attack you or your work, personally. I'm sure you did a fine job of whatever tasks you had. Just to be clear, it's certainly possible to work on something without knowing that it's not done for purely altruistic reasons.

But you're right, this is silly.
Are you Gay? Here is the perfect way to come out the closet to your family.
Japan Airlines says smoke seen coming from Boeing 787 battery
Data channel is going to change everything when it's ubiquitous.
I agree.

He tried reading and stayed up reading and it didn't work. But what about stopping all electronic things after 21:00 and then reading on your couch NOT bed, then go to bed at 22:30? You'll sleep like a baby.
I find it interesting that Tesla hasn't reached out to owners yet. It seems like something that should've gone out in a basic email to their email list of Model S owners...at least to put those of us who use the 14-50 adapter every day at ease...
http://www.fjc.gov/public/pdf.nsf/lookup/caseman2.pdf/$file/... (Figure 4).

The D.C. Circuit has 10% criminal cases. 5 circuits have above 25% criminal cases. The D.C. Circuit has over 30% administrative cases, most circuits have under 10%. The D.C. Circuit has almost no private prisoner cases (cases by prisoners against state officials for violations of rights), while most circuits have over 15%. The D.C. Circuit has over 20% U.S. civil cases (civil cases in which the U.S. is a defendant), while most circuits have under 5%.

Even within those divisions there are relevant distinctions. An appeal from the Board of Immigration Appeals is an "administrative" case, but it's a much simpler matter to resolve, usually, than say a challenge to an EPA regulation. So while the 9th Circuit has almost 30% "administrative cases," each of those are likely much simpler to resolve than each administrative case on the D.C. Circuit's docket (not many people are getting deported from D.C.)
Scala has value types.

case class MyNewType(x: String) extends AnyVal

What do you want to do that that isn't sufficient for?
http://blogs.cdc.gov/safehealthcare/2013/03/05/the-beginning... is the CDC blog article about this report: http://www.cdc.gov/vitalsigns/HAI/CRE/ which is about the rise of CREs in healthcare.
Title is a bit link-baity, but the product is quite cool.
These probably work wonders on your sex life too.
> It leads to the situation where a manager could fix something small in the same time he communicates someone to fix it

And when you have 50 small things? Or when the one small thing turns out to have been bigger than you thought, and you waste time trying to do the work that the engineers are probably more familiar with because one of them has been working on the same thing for months? Or when you have managing to do?

> Or situations where the manager slowly loses touch with technology

This is what design reviews are for.

> It's not likely someone will "understand" programming over the years without doing it constantly

I don't necessarily ride bikes over the years. But I understand it well enough to look at a bike and see how it works, or tell someone else where to go and how to ride it.

> Instead, there's maybe one person who takes the responsibility of managing work,

Like a manager?

> but does programming or other non-managing work the rest of the time

What 'rest of the time'? You mean when they're not fulfilling the first obligation you gave to them, which is managing work?

> The engineers can also do a bit of managing, but they'll focus on the engineering.

Why not just let them focus on the engineering? Why give them extra crap to do when somebody else was already tasked with managing the work?

> The assumption is of course, that managing work can be automated away sufficiently

You can't automate managing work. That's why it's called "management". Because you have to do work to manage it.

> and the team is a not huge. These are realistic assumptions, but are often untrue because of organizatonal flaws (or flaws with the manager).

Or because the organization is just big and the workload is high.

> baseball is not reinvented every 5 years. Programming quite often is.

Programming has not been "reinvented" in the last 40 years. It's pretty much the same, with some languages and tools re-addressing the same issues that were seen decades ago. Programming evolves, but so far it has never changed so much that an old programmer can't figure out what's going on with a new language or tool or system after looking at it for a while.

When you're a manager, you don't sit in an ivory tower and stick your fingers in your ears and expect to know what the hell is going on. You are constantly reading documentation released from teams within the company and become aware of changes between releases, hopefully well before they come into effect. You can even set up and maintain a development environment to run unit tests to verify your application works, reviewing build reports, and so on.

I think the reason so many people underestimate what takes up a manager's time is mostly they're people who never learned how to be a manager; they're often glorified team leads with the privilege to fire someone. It does a disservice to the people who have skills that don't apply to programming.
You know what's amazing? That there's 30k electric cars out on the road today.
I love it, although I found I lack math knowledge to really be good at it.

I enjoyed solving a few of those problems using SQL, that was fun.
I second this suggestion, The Master Switch is a great read.
I think the email is being latched on as a motivator too much in this case (because Oracle is obviously evil).

The policy more likely is: We pay X dollars for position Y in the USA, and less than X dollars for position Y in India per company policy. There isn't anything illegal about that. Also there isn't anything illegal about not bumping up his salary if he moved from India to the USA (even though I don't agree with this).
I first saw them demo this at the October 2012 HTML5 Developer's Conference.

We attended their last two SF "meetups" in December 2013 where they promised they would release the code right then (or the day after).

Still no release, and no further mailings. This is effectively vaporware in my view, and they can't indefinitely dangle this carrot in front of developers before we get fed up.
I previously worked on this project, and most of the devices we handle are not communicating over http. The goal is to manage long-lived TCP/IP connections.
You could just use a square of cardboard... why use electronics at all :)
AMD Kaveri Review
I've had quite a few younger friends ask me for help with Java so they could program plugins for Minecraft.
I'm starting to wonder whether managers are really necessary in most programming firms.
In Notch's new space game ox10c you'll be able to write assembly programs for the DCPU-16 ship computer (spec at http://dcpu.com/dcpu-16/). The game's release date will mark the end of most programmers' productive careers.
Let's make no mistake about it: Javascript has been a multi-billion dollar focus by several top-tier engineering companies for almost two decades. It's more accurate to say that Javascript has succeeded despite its limitations.

There's no denying that the PNaCl is a superior approach, and if we were starting from square one would be the smarter design as well. That said, a well entrenched language supported (and, crucially, maintained) by multiple vendors with loads of developer intellectual investment should win this competition.
>Alright, who in your company knows what hardware to buy at which datacenter for how much?

Everyone? I don't understand how you can imagine a problem like this. "Who in your company knows how to tie their shoes?"

>What software is going to run on it? who picks that software? How do you get data onto it? How do you get data off of it? What happens when it goes down? How do you monitor it? How do you scale it to two servers? Or more? Who is going to do that? Who is going to know all that? Who else is going to know that so your company doesn't fail when the first person isn't around?

AWS solves precisely zero of those problems. It isn't magic pixie dust, it is renting Xen VMs.
JQuery’s CDN Serving Billions of Files, Trillions of Bytes
Doesn't that kind of imply we're screwed when it comes to sustainability?
Markov chain seeded with the positive phrases:

Fall locations it goes well striving to the builds. If you want one thing: her new crown. Realize the card quarterly, make sure your host will likely school. Free access completing the offer of this new room and achieve their win. Showing the hard work, serious about playing with the builds.

And negative phrases:

For kids, know you mission is meeting pearl. You select a panels way of life at the eyes of the ancient and seem like digging. Make up akin to a thousand dollar professional. To get great, expand and extremely this option a broaden to feeling that stands. Needs a crowd and makes a broaden to come see explored ears. Items that college students and write using some much closer.
What is an alternative model of the cat?
The US government doesn't realize the implications of their actions. A day will come when the US needs German help, support, or assistance in an area of global importance and the Germans will be very reluctant to help because of this

Presumably you're referring to the US invasion of Iraq.

But I don't think something like the German refusal to cooperate back then is going to happen again. All that matters is money, and German's economy is (solely) based on exports. They need the American consumers for their own good, and German cooperations will make sure they keep their markets.
Well... my favorite startup is Fogbeam Labs, and I get a salary of a whopping $0.00 / year. :-(
There is an experimental "render DOM content to texture" extension supported by Mozilla called drawWindow that should solve a lot of this.

https://blog.mozilla.org/tilt/

https://developer.mozilla.org/en-US/docs/Web/API/CanvasRende...

Unfortunately it is not yet available for web content (browser extensions only).
"via satellite video for a live conversation"
I hear Framer(http://www.framerjs.com/) is pretty sweet.
The problem I see with AMD's APUs is the GPU performance, even if it's twice as fast as Intel's GPUs, both Intel & AMD's integrated GPUs are totally adequate for 2D graphics, low end gaming, and light GPU computing. Both require a discrete card for anything more demanding. IMO AMD is sacrificing too much CPU performance. Users with very basic needs will never notice the GPU is 2x faster and people with more demanding needs will be using a discrete GPU either way.
I agree that it reflects some of the absurdity of the patent system, but only incidentally... language is flexible, and how people use it to describe something doesn't inform the nature of that thing.
Please don't act like Oracle is the only SV company doing this. The free markets decided that pervasive racism in compensation is OK in SV.
Fantastic read. This article provided more insight on building startups than any others I've come across.
>> "Everyone gets 6 colored backgrounds to choose from for free."

Thanks that's what I suspected. Great job on the update.
paper : http://www.nature.com/srep/2013/130912/srep02617/pdf/srep026...
I've been following the norwegian Tesla Model S forum closely the last couple of weeks. The winter set in a couple of days ago, with temperatures down towards -20 degrees celsius. Lots of Tesla owners have serious issues with charging. The car doesn't accept charge, stops charging before it's done, etc. Luckily, third-part charging cables seem to work flawlessly.
It would be great, if they had a decent plugin model that permitted use of an accessible language.
I do the same thing: I have a sleep alarm, instead of a wake alarm. When the alarm goes off, I take 1mg melatonin. [1] About an hour later, I naturally want to sleep. Otherwise, I'll end up phase-shifting once again.

[1]: http://www.gwern.net/Melatonin
Petition signed by tens of thousands eases prison life for Pirate Bay founder
I understand your point, but I just don't see the ethical implications. Net neutrality, may be important, but it is a legal directive. Not supporting, or actively working to abolish net neutrality, isn't unethical.
Have you even read the Universal Declaration of Human Rights? Articles 23 and 25 are not supplanted by Article 27. In fact, Article 30 specifically states that you cannot interpret the UDHR in any way that would allow you to remove rights set forth in previous the articles. And, as surprising as this may sound, the UDHR doesn't specify order of importance based on word count.
There are a lot more than that. Nissan will soon ship their 100,000th LEAF.
sorry, generally speaking the point of a taxes is NOT to cover externalities, it is to control the populace and to fill the coffers of the state. Exactly what externalities do cigarette taxes cover? International trade duties?

Taxes generally fail in the pursuit of correcting externalities because taxes are set by policy and committees are notoriously bad at pricing. The generally better way to cover externalities is by propertization (so a carbon AUCTION - and not cap-and-trade which has all sorts of politically motivated loopholes and subsidies - would be smarter than a carbon TAX). Furthermore there are plenty of activities that incur externalities (such as homelessness) which we probably shouldn't be taxing.

An even better way to correct externalities is to stop making them externalities through social action - get people to value things like companies that destroy the environment less. It's hard work, but you just have to not be lazy in your social action.
Blue light. It's the whole reason f.lux and blue light filters exist, and why the Kindle Paperwhite is such an amazing device: front-lit with no blue light.
> And GOG refuses to add GNU/Linux support.

Yes, that's one of their downsides. Even their reasoning is becoming less and less sensible. They claimed they still can't figure out how to offer long term support on Linux. May be Docker can help them.
"I often have to back off of idiomatic Scala to achieve these goals (especially when it comes to GC pressure). "

Can you give an example of when you had to do this? I often wonder about the performance costs of chaining together several collection API calls.
I think cats are awesome too.
I think you may have misunderstood the purpose of Mantle and that demo. Or he may have explained it poorly in the video.

Saying We are GPU bound even when we underclock the processor is attempting to illustrate how cheap Mantle makes issuing tons of instructions to the GPU. Mantle doesn't make the GPU faster, it makes submitting tasks to the GPU faster in terms of CPU-time.
Why the world needs OpenStreetMap
Stealth Addresses
Still pales in comparison to http://www.targetprocess.com. It's unfortunate as many companies use Trello and as they grow they're locked into certain frustrating behaviors that create all sorts of painful workarounds and manual processes to cope. For example, it would be nice to have sub-cards, or the ability to break cards out into different pieces as is usually necessary with user stories with tasks. It would also be nice to turn checklists into their own cards, rather than creating a new card and then adding checklist from a different card.

It would also be nice to be able to multiple select cards, move cards to top, move cards to bottom, etc, etc. I won't even get into reporting. I could go on and on.

Anyway, these are definitely welcome improvements, but Trello for me is still far from being a really useful workflow management tool.
Engineering SimCity for Offline Play
If we are doing satellite interviews for SXSW, why not Snowden?
> what you wear is... as relevant as the architecture, the decor, the food on the table, the scents in the air

So what you wear is completely irrelevant? Or does Martha Stewart a better security analyst than Bruce Schneier? With no disrespect intended to Dr. Schneier, she certainly has better decor, food on the table, and scents in the air.
Thanks for the reply. We have a similar architecture where I work so this is interesting to me. A couple more questions if you don't mind:

- Do you use any tools for orchestrating the rollout of those schema changes or do you just have some homegrown scripts?

- Do you separate your schema versioning and deployment process from your application versioning and deployment process?

- How do you handle cases where backwards-compatibility is not possible? For example, a new application feature that depends on a brand new table.
Not exactly paragraphs but I have a link to SVG on Wikimedia which explains it quite good I think: http://commons.wikimedia.org/wiki/File:US_military_bases_in_...
The thing I find stunning about Minecraft is how you can learn about redstone wire and all of gates/flipflops/howtouse/etc and none of it actually feels like learning. Another game that teaches you to code without it feeling like learning is Garry's Mod's Wiremod, which lets you write a program that can manipulate the game world or other wired components.

I can't help but wonder if the formula behind these games is reusable. Imagine if large swaths of technical knowledge could be taught through a creative game like Minecraft/Gmod. Another amazing part of this formula is that it imparts the "Builder's High", an experience that may be completely foreign to children/adolescents, and could completely change how they feel about the creative and engineering process. There's a lot to be learned from the Minecraft formula, I hope there's game devs out there who recognize it and are willing to build on it.
I taught my 5 year old to search Youtube with Google Speak Now [video]
I would argue that the Fair Use Doctrine means it's probably not a violation.
Slightly off-topic, in addition to the DRM, the Raspberry Pi has a proprietary firmware that is not open source, so it's difficult to bake your own bootloader.
Holy shit, that was fucking incredible. This comment made my day. Incredibly humorous and well written response.
Mooshimeter: The ‘Why Didn’t I Think Of That’ Multimeter
> Do you intend to discourage people from becoming rich by taxing it?

That's not the intention, but perhaps a side-effect. A minor one, at that. I'd imagine it would be very difficult to discourage people from becoming rich. A progressive tax schedule certainly does not do much discouraging right now.

Now that I answered your question, perhaps you can return the courtesy:

Does there or does there not exist a high enough degree of income inequality such that there is a cost borne by society?
https://www.blitz.io
Very insightful piece. Great to see advice and tactical tips grounded in a real life case study.
I do not know a lot about the things outside China. But Japan is another example that many foreign Internet companies struggle. Maybe we could add Russia. These markets have something common.

HK and Taiwan are too small market to have strong enough local team.
I use trello because it's simple, not because it has all sorts of options that I need to worry about or navigate through.
Most organizations have general counsel staff that they pay hefty six-figure salaries.

They get paid whether they're in court or surfing reddit. Might as well make them work for a living.
Much of the use is as a feed additive. Some of the antibiotics shift the chemistry of the rumen, which increases the efficiency of the feed and also prevents a condition the animals get when they don't adjust to grain.

I think there are also antibiotics that promote growth through some other mechanism, and feedlots also tend to have higher therapeutic use of antibiotics.
Colours are assigned emotions. This occurs more frequently. I think this will bring you much enjoyment in days following.

http://www.amazon.com/The-Coloring-Book-Dover-Nature/dp/0486...

Enjoy the happiness happening onto you right now.
6 hours left Advanced Web Development with Django *almost* at its stretch goal