skysight-inc/HackerNews huggingface dataset:
Okaaayyy... Can I buy NAD+? Or is the magic in using sIRNA[1] to inject NAD+ into the pathway?

I have read on Wikipedia that our body can generate it.

Moneyquote:
"In organisms, NAD+ can be synthesized from simple building-blocks (de novo) from the amino acids tryptophan or aspartic acid. In an alternative fashion, more complex components of the coenzymes are taken up from food as the vitamin called niacin. Similar compounds are released by reactions that break down the structure of NAD+. These preformed components then pass through a salvage pathway that recycles them back into the active form. Some NAD+ is also converted into nicotinamide adenine dinucleotide phosphate (NADP+); the chemistry of this related coenzyme is similar to that of NAD+, but it has different roles in metabolism." [2]

And: "This NAD+ is carried into the mitochondrion by a specific membrane transport protein, since the coenzyme cannot diffuse across membranes." Link: http://www.jbc.org/content/281/3/1524 http://www.ncbi.nlm.nih.gov/pubmed/16291748

I can buy Tryptophan [3] and D-Aspartic Acid (DAA) [4] pretty easily and legaly. Would an overdose in Tryptophan have the same effect? UPDATE: http://aminoacidstudies.org/l-tryptophan/ Yes, Tryptophan overdose is bad!

I'm sorry, I'm pretty good at absorbing all kinds of scientific materials, but I am really not familiar with all the "body science". That's why I'm asking you, if you know what would happen with regular Tryptophan overdose. I know that DAA can destroy Neurons when overdosed and should only be used according to the RDA.

I don't buy that it's sooo expensive. That's either because researcher's monthly wage is astronomers, or the lab equipment they think is needed is too expensive. I am sure it can be done much much cheaper without the advantages of mass production. You and I currently synthesize the NAD+ thing for free!! The problem they solved, should be repeatable with cheaper equipment or even at home. I would like to have a cat, dog, hamsters or fish that live longer. (Parrot's already live pretty long, but I guess they'd be funnier with more NAD too)
--

[1] http://en.wikipedia.org/wiki/Small_interfering_RNA

[2] http://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleoti...

[3] http://en.wikipedia.org/wiki/Tryptophan

[4] http://en.wikipedia.org/wiki/D-aspartic_acid
Global oil production in 2013 increased by 2.2%. Natural gas production increased by 1.9%.

http://www.bp.com/en/global/corporate/about-bp/energy-econom...

http://www.bp.com/en/global/corporate/about-bp/energy-econom...
Looks like the tweets got deleted...in any case, am I missing something here. Is the email received by the OP actually sent by a human? RapGenius already has high results...it can't be terribly efficient for a co-founder to be sending manual link requests, right? Terms of service aside
It's important to remember/realize that no one, outside a handful of folks, understood what the NSA was up to until the last 12 months.

There were loads of people - members of the general public, security researchers, government watchdog types, privacy advocates, crazy conspiracy nuts, etc. - who very strongly suspected, for good reason, exactly what turned out to be going on.

ECHELON started in the 1960s. Rumors about it were everywhere by the early 1990s. It became so famous it was featured in pop-culture movies, TV shows, and video games.

There was at least one good book (note 2005 publication) that showed how it was possible to piece together some pretty good guesses about what was happening from unclassified information:

http://www.amazon.com/Chatter-Dispatches-Secret-Global-Eaves...

In short, that book argues the NSA was expanding its eavesdropping capabilities so enormously, so quickly, that the only reasonable target for it was "everything." There simply weren't enough top-secret, diplomatic, or encrypted messages to justify the infrastructure devoted to the task; the NSA had to be developing the ability to listen to absolutely anything it wanted to.
Yeah, I mean just look how afraid Clapper was of lying, completely knowingly, to the Senate under oath. He must really be afraid of putting himself out there as the threat to his personal freedom is far too great.
> I have friends with computing science degree yet they cannot code or have shipped software.

So do I, but CS degrees are not about memorization. At least not in North America or Europe. For my CS degree, I had to follow the math and deliver code. Toy code of course, but its a long way from "recalling and reciting references." If it had been about memorization I would probably have failed.

I also know people who say they got CS degrees through memorization and the ability to recall and recite references. They are Indian and Chinese. And they can code (even if they believe their degrees do not help.)
I really enjoyed Discover Meteor. I bought it myself when it was originally released as my interest in JS increased and found it quite rewarding, and very well documented. I wish it went deeper into testing, but for a quick bootstrapping into MeteorJS nothing is better and it is a fun project; especially with the advanced sidebar sections.
> Are there specific examples of problems that splitting CA would fix?

Not anywhere in any article I've seen -- just more platitudes about the size of government and vague allusions to California being ungovernable. Particularly frustrating in an article that announces it gives details.

There are indeed some issues that make California difficult to govern, but if I were picking them out, I'd put limits to the power of legislators to make policy without supermajorities and the initiative process itself pretty far above the idea that we just don't have enough state lines in the region ("Hi, I think state government is a terrible problem and to solve it we should make 5 more of them.")

It seems like a good guess that what Draper really means by "ungovernable" is that as the balance of power and philosophy now lies, there are some personal business or political goals that he's unable to bring to pass, despite significant wealth or influence.
Neetu Chandra Hottest Video 
Neetu Chandra Hottest Video
Found this to be interesting... "We’re proud to be a Certified B Corp."
http://en.wikipedia.org/wiki/Benefit_corporation
http://www.bcorporation.net/what-are-b-corps
Up the Irons
His job is done, now it's up to the rest of us.
The only reference I see to "Special Administrative Measures" involves communication with prisoners: http://en.wikipedia.org/wiki/Special_administrative_measure

Even articles in publications like "Reporters' Committee for the Freedom of the Press" refer to this phrase as a thing for prisoners: http://www.rcfp.org/browse-media-law-resources/news-media-la...

So it's unclear what you're talking about.
Half the U.S. is already covered with snow: earliest in past decade
Awesome summary - thanks for sharing. Now I appreciate the beauty of his creation much more, despite the fact it was designed to kill.
Perfectly reasonable in my opinion.
Yeah, it's definitely fair use to make backups of your own games on the same medium. Tools like the Retrode are great to use with your carts.

Nintendo is attempting to control the message (no one is going to check them on it and they're deliberately being ambiguous) and scare people away who would normally just be pirating their old games.
Tinfoil hat territory was granted statehood a while back, in case you weren't paying attention. I don't understand your willingness to underestimate our government's abilities to mislead the public.
Ah, looks like there's an issue with the iHackerNews API itself, which I don't have a hand in. You'll want to hit up @ronnieroller on Twitter. Sorry I can't be of more help. :/
> Central California farm communities would get more money diverted to waterways and agricultural projects. Northern Californians could finally get the school and public transportation spending up to the level that they're craving for

Internal to California, a lot of the tax base comes from urban centers that would no longer be part of the same state. Federal dollars might get spent differently, I guess, but they'd also be allocated differently, and the more populous states would have at least somewhat more lobbying power.

So, yes, while the new states would be able to prioritize more independently, it seems likely that the pie they're drawing from would be more limited -- possibly much more so.

> Southern California would probably build more highways and give more incentives to tourism and entertainment industries.

No tax base problem here, so this is potentially true, but I'm not sure it's one to put in the plus column.
Wouldn't that make it a proof and not an opinion?
I don't see it as "whining" as much as a reminder of the "what we see is all there is" bias. We may never know what's being hidden from us, but it's worth remembering that we can be near-certain of the existence of unknown-unknowns. The point is that all of this may be the tip of the iceberg. It's intellectually interesting to think about, with potentially grave consequences for day-to-day life.
Oppo N1 CynogenMod Limited Edition goes on sale for $599
Why is it illegal, that's the question! It does not harm anyone!

Ok, but one doesn't need to fully own the cable, to run a startup's server on it. They can forbid SMTP servers, ok, but HTTP etc. should be allowed.

You mean I need my own hacker satellite to own it? Even then, how would you connect your satellite to the network?
For large populations it's not strongly a function of population size - a 500 sample is almost as good for a 100,000 population as it is for a 100,000,000 population (which is not very good at all).
I'd suggest that perhaps the entrenched culture of traditional taxi companies is negative in so many ways that even with the best software they'd be at a disadvantage. Pure speculation of course, but from reading the article it doesn't seem that farfetched.
> Americans you are lost. It's been nice knowing you.

I think this sentiment has been expressed since the 1800s. Same criticism applied to Rome... and all human civilization, really. We are a lost species, it would seem.
No argument on substance; someone who has no problem maiming or murdering in order, not even to save the life of a tree, but merely to punish people for having in some way been associated with a tree's demise, so places himself far beyond any civilized pale. Such a person deserves at the very least a stiff term in prison; should he succeed in his vile endeavor, he is best rewarded with a cigarette, if he wants one, and a nice sunny place to stand and enjoy it. (In case that's not sufficiently clear, I am talking about execution by firing squad.)

But you might want to avoid that word 'terrorist'. It tends to give people an excuse to shut off their brains and feel good about it, where convoluted rhetoric like mine tends to serve as an attractive nuisance ("I could give up on this, but then whoever wrote it might look smarter than me") for long enough to get a point across.
Desktop version - http://www.theatlantic.com/politics/archive/2013/12/the-war-...
ok, i'm done here. you are probably a zionist.
"near-certain of the existence of unknown-unknowns. The point is that all of this may be the tip of the iceberg."

True enough, but I think everyone already knows that.

The content of the recent Snowden interview, not so much.
Despite my curiosity for emerging technologies, this type of bio-hacking scares me. I'm all for augmenting and virtualizing reality; however, embedding devices within the human body makes me cringe...

Imagine if Google's next big product involved a brain-computer interface in which the mind communicated directly with Google search. As great as this sounds, the phrase "security concerns" belittles ethical issues here. On the other hand, though, given medical resources, I would probably do the same myself. I guess my fears are caused by mass production, mandates, and lack of control, rather than the technology itself.
Not sure where you were going at the end there, but for what it's worth: modern day conservatives are not equivalent to the confederacy in the civil war. Abraham Lincoln was a Republican.

The issues that polarize Americans today are very different from what they were 150 years ago.
I suspect it's not doom mongering for some of the goofier regimes propped up by oil money. Would not want to live in Saudi Arabia when the money runs out.
Asperger syndrome (AS), also known as Asperger disorder (AD) or simply Asperger's, is an autism spectrum disorder (ASD) that is characterized by significant difficulties in social interaction and nonverbal communication.

A large majority of hackers have aspergers. A friend of mine, the famous hacker Captain Crunch, aka John Draper, is immensely talented yet has problems understanding normal human communication schemes.

It's possible that Crito has aspergers or is a swagtard like the Rap Genius guys. If he has aspergers, it's perfectly reasonable for him to not understand the point I'm making as his ability to pick up on nuances of human communication would be flawed.

In the swagtard case, he needs to defend his habit of wearing glasses indoors, otherwise his self-image would immensely suffer, and his ego would shatter. That's worse than death for those who judge themselves by their ability to be cool.

So how can you compare what I said to a rape joke? Nothing is humorous here, it's all very seriously logical.
It's California. It's a strong blue state. What you need is a primary challenge.
His silence is highly amusing to me. :)
Plus, there are some things that I don't believe can be taught effectively in college. Stanford told me tests were good, but I didn't really believe it until I had to work on a legacy codebase without tests.

Best practices are easier to digest when you've experienced the problem they're meant to solve.
If the majority have accepted surveillance, it's probably because very few people, if any, have articulated the harms of surveillance in a personal, visceral way.

Privacy as an abstract concept is meaningless to most Americans -- thanks in part to pervasive data mining and targeted advertising by Google, Facebook, credit card companies, and so forth. That's not to say privacy doesn't matter to them. Children often want to keep things private from their parents. LGBT persons often want to keep their sexual orientation private from less tolerant members of society. But that's because the consequences of such a violation of privacy are immediate and visceral. In contrast, the automatic mass collection of data by the NSA doesn't have any more of a tangible impact on most people's lives than does Google's or Facebook's.

To put this another way, very few Americans have altered their behavior because of Snowden's revelations. And it's largely because the government hasn't given them any reason to. The NSA can read my e-mail, but I can safely say "Fuck the NSA" without consequence. In contrast, when I was in China, attempting to visit a prohibited website would result in my Internet connection being blocked for up to an hour. Or to pick an example in the U.S., making an illegal turn in front of a traffic camera would result in my getting a ticket. Absent that sort of "feedback" from the NSA's surveillance, the harms of mass surveillance simply don't click with a lot of people.

That's not to say such very real harms don't exist. The NSA's data collection is tied in various ways to the no-fly list, the war on drugs, and targeted assassinations, each of which result in visceral, immediate harm to real people. But from my perspective, the surveillance aspect of these stories have not been told particularly well.
The implication of course being that these people got their opinion from a different set of premises. Which seems to be jonnybgood's point: some people are approaching this from a completely different starting position and direction, and it's not obviously invalid.

Personally I worry about how long this takes to resolve; if it takes too long, there might be enough social value drift no one will be upset by this sort of thing anymore. And that will be a much harder to fix starting point. Well, I would consider it a state worth fixing, at least.
No I did not. This PDF and the White House NSA recommendations I have on my todo list for after the 25th of the month. Unfortunately, right now I cannot find the time to read anything this long.

That being said, thanks for the clarification and specific relevant facts from the PDF.
Agriculture in California is relatively unimportant, according to 2008 BEA statistics cited at http://en.wikipedia.org/wiki/File:Gross_Domestic_Product_of_... - just 2% of California's notional GDP. I think I have read 4% from another source, but either way it is marginal.

I tend to think that the comments on electoral statistics have this right. It is an attempt to tilt the Senate and Electoral College.
How the hell does this lead to stereotyping an entire race? Just so you know India and China have produced a large bulk of academics in computing science, across various educational institutions in North America and Europe. So I find your statement very arrogant and condescending.

Of course you can't memorize your way through a CS course requiring you to write code, but my point is exactly that, school doesn't teach you to actually be able to ship code or write something. It's something one must discover on own terms.
This is great! I always thought he sounded like an interesting person.
What I find when I work with "pointy" data structures is that it really, really helps to draw diagrams to clarify your thinking. I can write a doubly-linked list extraction with my eyes closed (and it'd probably help to do it with closed eyes, since I can more easily picture what's going on) but it very likely won't look anything like yours... what's dec for? And all the extraneous underscores in the variable names, I don't see why you need them. What's wrong with p and p?
Or you could just SSH from your Android/iOS/whatever phone.

It's safer than typing credentials in an untrusted computer anyways.
It's a red queen race. (And even if you are number one, you can work on being number one for cheaper.)
Vim gtfo:  Go to Terminal or File manager
Namecoin is very early in its development. As a consumer, you probably shouldn't care. Yet.

But, as a software developer working in the systems management space, I care. And, as someone that has always been uncomfortable with the centralized control of the DNS system and the horribleness of most registrars, I care. Namecoin is one potential solution to the latter problem, and it's something that I need to have on my radar for the day when it may become relevant to the users of the software I work on.

To answer your specific questions:

Who gets paid in this value vs who doesn't? The miners who maintain the Namecoin network get paid. They validate and secure your transactions when registering domains. Right now, the cost to someone registering a domain with Namecoin is very low...a few cents to register a .bit domain. And, it is expected to remain low, as it is not an expensive network to maintain (relative to Bitcoin, for example; at least for the time being).

To register a domain with Namecoin, you install a Namecoin client, and make a transaction, as documented here: http://dot-bit.org/HowToRegisterAndConfigureBitDomains

You need a tiny amount of Namecoin to do this. It can be purchased with Bitcoin on many exchanges, or can be mined with Bitcoin ASIC mining equipment (it is merge-mined with Bitcoin, so it doesn't require resources to be diverted to mining Namecoin...but it also means it is not effectively mine-able with consumer hardware because a large percentage of the Bitcoin network is also working on Namecoin).

As for who can see the names? Anyone who has a DNS server that has .bit information. There are a few out there: http://dot-bit.org/How_To_Browse_Bit_Domains

But, it is mostly theoretical. There's little reason for clients to configure this, and until their are lots of clients, there's little reason to have a Namecoin based domain. But, maybe that'll change. I'm tinkering with it, and will likely launch some services around it before too long, as I think it's a really cool idea. And, while the implementation has had some hiccups, it's the best we've got...and the chain hard fork a couple weeks back (to fix some problems with name registration) was successful, so we're probably on a pretty solid footing now.

I, personally, find Namecoin to be one of the most interesting Bitcoin derivatives...it has a very clear purpose, and solves a problem that has been a minor thorn in every IT admin's side since the beginning of the Internet. It'll likely never see the kind of speculation that Bitcoin has seen, and that's probably a good thing. Domain names should be cheap, and responsibly used and managed by the Internet community as a whole.
Tests and behavior should be defined before the code.

I recommend you comment out all code, write the tests and then un-comment the code line by line.

This not only tests the code, but tests the tests and assures that you are covering the edge cases the code contains already.
> Here Maps is also going thru updates and is working better than before. Its a good map.

Here Maps is not a good map:

Go to here.com. Search for "東京" (Tokyo). It jumps to ... Beijing. ><

Ok, try using "tokyo" instead. This time it actually jumps to Tokyo. Zoom in to see what's around ... and ... oh wait, there's essentially no content. According to here.com, Tokyo has no buildings and only 5-6 roads in the entire city. For Nokia, one of the biggest and most important cities in the entire world is basically an empty featureless plain.

I'm not exaggerating, look for yourself:
http://here.com/35.6798245,139.7395558,15,0,0,normal.day

Essentially unusable. Good choice Mozilla!

[It shows a few rail lines too (though a very small fraction of those that actually exist), but when I zoomed in I realized that they're not located correctly relative to the other few landmarks that are shown... ><]
Your Idea is Great! You Just Suck
Still quite far behind what is provided by C# and Scala, among others. At least it's a step in the right direction. These are the first major language changes to Java in nearly a decade, say what you like about Oracle, but at least they have the funds to develop Java whereas Sun was running on empty.
Cheapest PAYG Mobile Phones For Christmas Presents - Cheap Smartphones
Is there a way to incubate people like Snowden? I suspect Snowden could be a spokesman or figurehead for movements in other countries, but I have a hard time thinking he could ever repeat another data dump without becoming a real spy. Could someone as public and recognizable be effective in getting inconvenient intelligence from other countries?
The world, especially the intelligence world, is more than black and white. A myriad hues exist, some of them dark and dirty, some grey. Here is a portrait of a man who is color blind. Experiencing the world only through a computer, he lacks the judgement to jump to the right conclusions, and goes thermonuclear only to find that mainstream Americans don't share his disability. He wants to be another Assange, but in the end he is another Manning.
Taking a lot on yourself, there, don't you think?