skysight-inc/HackerNews huggingface dataset:
Researchers injected a chemical called nicotinamide adenine
dinucleotide, or NAD, which reduces in the body as we age.
The addition of this compound led to the radical reversal
in the ageing of the mice.

While this is pretty cool, it seems that the most immediate effect would be a higher availability of adenosine triphosphate (ATP), meaning more energy "currency" for the body's machinery to work with [1] [2] (someone please comment if my understanding is incomplete). Used as a general lifestyle drug †, grandma isn't suddenly going to look like a sorority girl, but she may feel like one - a scary thought indeed!

Anti-aging technologies are going to introduce many philosophical questions; although, that doesn't quite seem to be the case in this specific instance since this compound will probably just improve the quality of the last couple decades of a person's life rather than drastically extend it. What's the difference between curing disease/prolonging natural life vs unnatural "anti-aging" technologies? At what point do we start grappling with the issues of immortality? Personally, I believe that the mentally-deteriorating effects of everyday life, including what one may call "sin," will be too much for the modern human to retain his/her sanity after a certain point. I for one would rather face death.

[1] http://www.genome.jp/dbget-bin/www_bget?C00003

[2] http://www.genome.jp/kegg-bin/show_pathway?map00190+C00003

† I say "lifestyle drug" here to denote elective treatment, although the effects of natural aging and death dying probably do not fit in the technical definition, which is to treat "non-life threatening and non-painful conditions such as baldness, impotence, wrinkles, erectile dysfunction, or acne"
git clone https://github.com/django-debug-toolbar/django-debug-toolbar...

cd django-debug-toolbar

python setup.py install

I guess?
I thank you for that repo. I forked, customised, and occasionally cherry-pick from dotfiles, and it has improved my everyday terminal use significantly.
hey it would no doubt stop billions of dollars being stolen.

Also, if you have this enabled, your purchase doesn't go through until you approve the charge. As for wireless reception... 4G & 3G solves that as it justs a text message going through.

Further banks who offer this could set a high default amount like $500 and the end user could change it to something higher.

Further, further as noted by another here, the user has the ability to enable this or not. If you know you are a irresponsible drinker then this would not be a solution for you. Also, if your passed out drunk how are you going to pay your bill anyway?

This is something I want after being hacked and a solution that would suit my needs and many others who choose it.

Anyone have any other solutions?
Yup, they are giving out mortgages with all that free/cheap money, unfortunately they are only giving it out to themselves.
TY ^^
This is very true. It's proven itself over and over in history. The more stable, healthy, and developed a country is the less children it has. Europe and East Asian countries are having this problem right now as both have negative population growth. In fact this might be the solution to over population. If I knew I'd live to 150 I'd probably wait till I'm 75 to reproduce and replace myself with children.
Don't worry, your reclassification request has been duly archived to /dev/null for later review.

They are probably going to receive tens of thousands of requests so I wouldn't expect them to be read by a human. If that's the case they'll just prioritize by frequency of report. Obviously it's all conjecture on my part.
The Fault In Our Stars Project (Unofficial Soundtrack)
Then you have some work to do...
Perhaps you need to add some checks so different lines of text don't overlap on the image when their random positions are too close together.
First of all, generations are pipelined. If we live twice as long, the world needs to support twice as many people, not infinitely many.

Secondly of all, one of the problems with the baby boomer generation was just the "boom". The growth was not continued/sustained.

Thirdly of all, I figure with people spending proportionally more of their lives in a field instead of in school, plus population pressures, we'll figure out how to colonize other planets pretty quick :)
It's not the feeling old, it's the realization that you have, in fact, spent the first half of your life not doing the things you wanted to do. And then the realization that you better get a move on if you want to get them done.

Motorcycles, Porsches, divorce + remarriage to a much younger woman, angel investing. You know, the mid-life crisis.
Actually, to quote "Masters of Sex"..

> Non-performance is an equally valuable part of the study

If you could submit links to a non-framework app or two you've built, and elaborate on why you don't use them in your answer, it would also be tremendously helpful.
We were having a discussion about Telegram and similar uses of encryption, a discussion where I specifically responded to a remark on the strength required of Telegram-style encryption. I would hope that most people are capable of interpreting the context of a remark - especially embedded in paragraphs that expand on it. Rather than, 'fall[ing] for it!'

-sigh-

Beyond that I'm not going to engage with you any further, on this or any other point. You strike me as a bully, restrained where you are simply by the absence of an excuse rather than the presence of decency. As such, I've no interest in associating with you.
It's perfectly fair for the 20 year old, because they won't compete. It's not fair to the 50 or 60 year old, who has to compete with someone who has equal experience but is younger.
What's your blocking method?

Short of setting up a nameserver and going authoritative for the domain (I've done that, I'm feeling lazy), /etc/hosts doesn't take wildcards for hostnames.
Ageing is a genetic disease. It has to be cured. We evolved to adapt to specific environment. Now that we are changing this environment we must change ourselves as well. Everyone should be given an option to die but it should be just one of a few options.
Schadenfreude: The All Presidential Version
Funny, I just saw a friend's Android phone get bricked by an update about two years ago. It was in a state I probably could have recovered it from if its bootloader were unlocked, but it was beyond reach of Joe User.

I've also bricked or seen bricked routers, external HDDs, and TVs in the last five years.

Many TVs, actually, if you include pre-release units. As far as I can tell, most of them rely entirely on testing to avoid bricking devices. They make zero provision for the inevitable case where something goes wrong. Power failures during updates remain a frequent cause of bricking.

Your "exception" is quite a common case when firmware updates are performed manually. Those failures have, of course, dropped dramatically since devices started being able to self-update, but they're far from the only such failures out there. The "some reason" depends on the product and manufacturer, but it's usually a combination of laziness and penny-pinching. Somebody didn't want to do the work, or somebody else didn't want to pay for it to be done.

I've seen the processes that lead to these situations up-close. There are a lot of engineers out there who don't think about failure modes, and a lot of managers who dismiss the engineers who do as paranoid and/or troublemakers.
Let the duel of snarkiness continue.
Such sad

OMG no persistence!

Very copy/paste

(It provides the output as CData, so it doesn't give you a URL that you can then copy/paste to send to friends. You would have to save the image locally and then upload it somewhere first. Maybe plug this into imgur in the backend and redirect to an imgur URL if someone clicks on 'View'?)
NSA Panel Member Recommends Increased Data Collection
> I don't know why you were voted down.

Because even if he was right, using the "M$" abbreviation is bad form when other people are trying to have meaningful conversations.
Everything you say might be factually true, but it doesn't follow that no-one has been bothered by it until now. Some of us have been raising concerns about things like pervasive surveillance by governments and/or big businesses for some time. But the issues aren't sufficiently well understood yet by the general population, nor directly harming a large enough subset of that population, for most people to feel strongly about them.

Particularly with the relative hardship many have faced over the past few years, they are quite understandably more concerned about things like keeping a roof over their head and putting food on their children's plates. But every now and then you see people up in arms over things like how much it costs for a new driver to get the (legally required) insurance in the UK today, and you get a glimpse of where we're heading if we continue on our current course.

A disproportionate number of the people I know personally who already share similar cautious views to my own are involved with technology. I suspect this is because of the awareness we share of how technology and in particular all this data could be used, even if the data is merely being collected today and not yet exploited. Most people don't realise the full implications of what is already happening yet, so they aren't concerned enough to act today, but that doesn't necessarily mean they would still be OK with something if they were fully informed or knew that it would eventually affect them or their loved ones and not just other people.
Dear Jailbreak Community
Right. Which is why my first advice to a non-tech person starting a business is still 'go out and get Access'. Because I can pitch as hard as I like for Node and Angular, I'm never going to make callback-passing and dependency injection as intuitive as 'New Access Database Wizard'.

Come to think of it, 'use Access' is pretty good advice for businessy techies, too. It's a lot harder to rabbit-hole when the earth is actually molded plastic. :)
> This kind of heterogeneous data tends to be very much discouraged under REST, but often very handy in producing real world reports.

This is nothing to do with REST. Read the Wikipedia article for a crash course.
From Aubrey De Grey:

Short answer is it’s not all that big a deal in biomedical terms. It’s a great discovery in terms of understanding mitochondria, and it provides a new way to rejuvenate mito function, but it doesn’t tell us that rejuvenating mito function in isolation in an otherwise still-old animal is a good idea -- and there have for many years been other ways to rejuvenate mito function which have not led to longer lifespan in rodents, notably acetyl-L-carnitine combined with alpha-lipoic acid (which has been marketed as Juvenon).
Well, I certainly can't plead innocent. ;-)

I've realized for a long time that what's gotten me through school and life is a series of accommodations for the brain that I happen to possess.

Oddly enough, things "clicked" for me in terms of developing the deep understanding underlying the symbols, but not always concurrently with whatever course I was taking.
Thank you! Will buy your book and support your kickstarter
The chip still provides a "track 2 equivalent" to the terminal - http://www.emvlab.org/emvtags/show/t57/

If an attacker intercepts that, they can get the account number from it and potentially use it for online purchases. But they wouldn't have the postal code or security code, which most but not all ecommerce merchants require.

It's a rather flawed system - there are strict protections around certain cardholder data like PINs, but none of that really prevents fraud since just the account number is enough to make certain purchases.
An important one is that XML does not map cleanly to any programming language's typical data structures, even those that explicitly support it. It always turns into an elaborate object hierarchy with awkward query syntax. The combination of unique named string-only attributes with ordered, non-unique named child objects is awkward and ambiguous (i.e. should that property be an attribute, or a child?). Contrast for example with JSON, which translates directly into arrays and hashes, structures available in any decent language.

E.g. you have <user name="john" address="123 Oracle Road"></user>

Now you decide you need multiple addresses per user. Do you: a) invent an ad-hoc string serialization scheme for the address="" property, or b) completely restructure your XML into:

<user name="john">
<address>123 Oracle Road</address>
<address>456 XML Lane</address>
</user>

But in that case, why not just make every property a child?

XML also spawned idiotic things like XSLT, which most agree is pretty terrible. If you try to use XSLT for HTML templating, by definition you have to escape every meaningful HTML character like "<>&'". If you wish to print one of those characters in your templates, you have to double escape them. No designer I know of would touch it with a ten foot pole, and every programmer I've met who loved XML and its associated technologies was terrible at their job.

Basically XML is strongly associated with the bloaty enterprise Java world, who used XML as their hammer to beat down anything remotely nail-like.
I don't see what the big deal is. If you use a credit card (not debit card), you aren't the one be defrauded. In the U.S., consumer protection laws limit the liability due to credit card fraud. If the fraudulent change is more than $50, the customer can dispute the charge within 60 days. During the investigation period the credit card company cannot collect on the disputed amount nor can they report this to the credit collection agencies. In other words it's the bank that out the money. This is why I prefer credit cards over debit cards. With a debit card the money is yanked out of your account. The onus is then on you to recover the funds.
It'd be a bit silly if they have to send a soyuz up to fetch the astronauts in case of an emergency. There's currently 2 soyuz capsuled docked to the station, they can leave on a pretty short notice, I'd imagine they'd do so in the event of a death.
> I don't know why you were voted down.

Probably because they had to go out of their way to describe them as M$. Googl€, App£e and ¥ahoo work just as well, but are never used.
Maybe most people are not capable of understanding the possibilities of a strong AI? It's not like we will just have a nice sounding personal assistant.
Why are people attacking Google buses?
Saurik did know about the Chinese company and tried to warn Evad3rs about piracy, but I read that Evad3rs thought that the app had nothing to do with piracy. [1]

(https://twitter.com/saurik/status/414836148737802240)
(https://twitter.com/saurik/status/414836169218592769)

EDIT:

[1] "In our agreement with Taig, we contractually bind them to not have piracy in their store. This was an extremely important precondition of working with them." http://evasi0n.com/l.html
Your phone is not only registered to the apple dev portal but also as one of 100 to the developers certificate.

With an enterprise certificate distribution is technically possible and many do distibute their beta software this way. But I am sure Apple will revoke enterprise certificates if they are used to distribute apps en masse outside the App Store.
Track your time on GitHub
I'm a zsh-er and use oh-my-zsh, but I borrowed the syntax highlighting, called it `sat` short for "source cat", and piped through less for paginated output:

# before use: [sudo] easy_install pygments
alias sat='pygmentize -O style=monokai -f console256 -g | less'

I like these kinds of projects, because someone always shows me something in my set up I don't have, and it's really trivial to borrow from them.

In return, I feel everyone should have a proper git log alias, here's mine:

alias logg="git log --graph --oneline --all --decorate --abbrev-commit"

Example output: http://d.pr/i/B9LT
Show HN: See how a node module is being used by other node modules
You want to let everyone die to maintain solvency?
FWIW the evad3rs team responded:

http://evasi0n.com/l.html
This post might be better without the mathematical abstraction.

> An employer wants to pay their employee as little as they can get away with, as long as it is less then the value that employee provides. Presumably, this company set such salaries.

> However, there are things that the formula doesn't take into account - they lose the ability to screw bad negotiators and convicts out of money.

> Similarly, if people are offered higher salaries elsewhere, it might be worth it for the company to counter-offer with something still less then the employees value to them to keep that employee, but they don't want to do the same for everyone.
Very good point, and I realize that I was being a bit sarcastic about standardized testing. In fact it's possible that if a particular set of coding questions gains widespread use, then it will function as a de facto standardized test, with the result that you predict. This could already be the case if both employers and applicants are searching online for lists of the best interview questions.
Anti-aging has nothing more to do with immortality than does, say, curing a particular disease.

Aging is only one of many causes of death; if we solve that one, there's still heart disease, stroke, getting hit by a bus...
Your thought process is linear. Try to model the consequences. 20 yeas old people will be considered kids and that's it. Otherwise you should opt for euthanasia because 10 year olds have a hard time competing with you today.
There has been a fair amount of research into the effects of manipulating hypoxia-inducible factor 1 (HIF-1) in lower animals, mostly nematode worms I believe. Interestingly this is one of the few manipulations in which either reducing or increasing levels of the protein in question can increase longevity. This is a sign that there is probably significant complexity involved in this outcome, such as in relationships with other mechanisms or that the effects of changes are tied to specific tissues in the body or locations within cells.

So this is, I think, an overhyping of otherwise interesting new research into a way to manipulate HIF-1 via NAD levels that is apparently an offshoot of past and ongoing research into sirtuins and aging. When considering the source of the wor - the Sinclair lab - the overhyping is perhaps less of a surprise than it might otherwise be: this is a group with a very large sunk cost behind them and little to show for it. Deep pockets nonetheless still back continued efforts, and they have a lot of experience with the press. This is a formula that leads to breathless press materials touting rejuvenation. The people who are really, actually working on rejuvenation are more restrained these days.

So I disagree with the tone of the publicity for this work; it's a great example of the mindless attention machine being manipulating into seizing on something that has little relevance compared to other far more deserving work.

I think that (a) these researchers have found an interesting set of interactions to help explain why manipulation of HIF-1 can affect longevity, and (b) the changing levels of that and various related proteins with advancing age are responses to accumulated cellular damage. Perhaps the most relevant damage is mitochondrial, given that cycling of NAD is involved in the chain of unpleasant results that unfold when mitochondrial DNA becomes damaged, or perhaps it is something else.

So to my eyes what they focus on isn't a cause, it's a consequence. The fastest way to see what causes what at this point is to work on repairing the known forms of damage rather than tracing back all of the myriad complexity of relationships and feedback loops in the cell - a task that would take substantially longer than just building means of biological repair for our cells and other small-scale structures.
You forgot:

Mr. Policy: I would like to learn more about Citizen A, but Mr. NSA is strongly prohibited from accessing data specific to citizens of this country. Unlike many rules this prohibition actually is taken seriously, with major consequences for anyone caught violating it.

Mr. GCHQ: Bob's your uncle. Would you like that in .zip or .tar format?
When I read the article that also popped out for me.

Unbelievably obvious. Obviously somethings are different in the Martian environment, but the laws of physics didn't just look the other way when they saw the rover coming.
The logo was done in the font Glass Tty VT220 -- which, fyi, also makes a very nice terminal font for your command line. (In fact, I have yet to see anything that matches it.)
This Week's Top Stories | The Next Web
Hi, that last link was my talk from 3 years ago. Last year at 29C3 a couple of friends proposed doing this kind of security with elliptic curve cryptography. See the lightning talks recordings. Their code is here: https://github.com/rtreffer/dht
An Asynchronous Dataflow Implementation – Part 2
Protip: Even if "reply" is missing, just open the "link" to the comment you want to reply to. Viola.

(Now just watch as pg fixes that)
> In many cases, these endpoints are customer-specific, and violate the living daylights out of the RESTful design paradigm -- often exposing 'flattened' views for convenience.

This doesn't violate REST. The WWW is the canonical RESTful system, i.e. A client enters the API (a website) via a common entry point (example.com), navigates using links, and manipulates state using a shared understanding of a common media type (HTML and HTML forms). Think about it, when you go to a web page do you expect it to be about strictly one thing, e.g. when viewing a blog post, do you expect it to click a link to navigate to each comment? No, that would be insane. Does that make it non-RESTful? No. It is perfectly reasonable for a resource to be composed of other addressable resources.
Congrats on posting about something you did on HN! Here's some feedback:

- Like a lot of such generators, you make the mistake of picking random x,y coordinates and not checking for collisions, which can result in situations like that (http://i.imgur.com/M7LyPqD.png)

- generating a nicer URL, as other commenters have pointed out, would be nice

- just as a FYI, when products use the terminology "as a service", it's typically because the product can be used in a programmatic way (i.e. it exposes its functionality through an API). That would be a good next step for your project!
I'm aware of this too -- there is a standing wave of businesses with technical debt from their smaller days. Much of the North American economy is underpinned by a volatile mixture of Act! ~2006, MS Access ~2003, and QuickBooks. None of these products like each other, and they are all obsolete.

This is at least a big a deal as, e.g, South Korea's eternal love affair with Windows XP. It shapes the whole technoeconomic apparatus.
This post fills me with questions. Foremost: What makes anti-aging technology unnatural compared to other medical treatments? To take one example, the smallpox vaccine was initially considered unnatural, and an affront to God[1].

[1] http://abob.libs.uga.edu/bobk/whitem10.html
I find this title funny since one day google's busses will go to these neighborhoods and then there will be protests about those residents being displaced.
Hey mate, I saw it from you answering my question on SO and have been having a play with it.. I really like it (even though I'm still struggling with my query!) and thought it deserved to be shared :)
Calorie Restriction for Life Extension mailing list.