skysight-inc/HackerNews huggingface dataset:
> The FDA introduces a bootstrapping problem wherein the proceeds from selling a potential remedy cannot be used to test it

To the extent that approval requirements applied by the FDA under the Food, Drug, and Cosmetics Act do that with remedies (which aren't at issue in this case, as it is about a diagnostic device not a tretment), that isn't what happened here, as demonstrated by the fact that the FDA allowed 23andMe to continue to operate for years after issuing the June 2010 letter in which they first raised the issue that the PGS fell within the FDA's regulatory ambit and that various approvals were needed to continue marketing it the way it was marketed.

The "stop now" letter wasn't set until 23andMe stopped working with the FDA toward meeting the requirements, so 23andMe in fact was able, had it chosen to do so, to use the funds from selling its device to test it.

> and no one other than the inventor can test it, because the product cannot be sold until after it is tested.

The FD&C Act doesn't prevent covered "remedies" (etc.) from being sold before they are tested, it prevents them being sold to prevent, treat, or diagnose disease until they've been tested. Products can be sold for, e.g., research purposes before being approved (and, in fact, often are -- one of the suppliers to 23andMe and other genetic testing services was dinged by the FDA for knowingly selling to 23andMe and other genetic testing services products for diagnostic use which were not yet cleared for such use but which were allowed for research use [1].)

> In any case, the only hurdle to selling should be "does it do harm?", and "does it work as advertised?" can be determined later, if and only if there is any doubt among the consumers.

This approach was tried in the health space for many, many years, and the results were deemed unacceptable. Of course, you may have a different opinion of what is desirable than that which motivated the Food, Drug, and Cosmetics Act, but simply asserting that the rules should be different is unconvincing.

> Elsewhere in consumerland, the product is sold, and independent testing is performed on off-the-shelf samples. Think Consumer Reports or Underwriters' Laboratories.

That's true for some consumer products, and its not true for others, generally driven by perceived risk levels.

[1] http://www.fda.gov/downloads/medicaldevices/resourcesforyou/...
STMicroelectronics' Microcontroller Powers AI Cars from Anki Drive
I think we've turned a corner too. I see fewer and fewer ridiculous patents. One of the reasons why, I speculate, is the advent of Google search :-)
>some pretty recent results -- most likely, the big breakthrough on ImageNet by Krizhevsky, Sutskever and Hinton (http://www.cs.utoronto.ca/~ilya/pubs/2012/imgnet.pdf), which uses convolutional nets.

kernels learned by the first convolutional layer (the figure 3. on page 6) have uncanny resemblance to Gabor function-modeled orientation-selective cells ("bars and grating cell") in the primary visual cortex. Looks like computers are on the right track :)

http://www.cs.rug.nl/~petkov/publications/bc1997.pdf

"The discovery of orientation-selective cells in the primary
visual cortex of monkeys almost 40 years ago and the fact
that most of the neurons in this part of the brain are of this type ..."

The difference here is a "number game" - visual cortex contains cells whose receptive fields' positions, eccentricities, sizes, orientation, number of excitatory and inhibitory zones (e.g. Fig.1 in the link) make a reasonable coverage for the space of possible values. Ie. the number of these cells is in the millions vs. 96. Of course it is only a matter of computing power to run all reasonable combinations of kernels emulating the real visual cortex, yet it would put immense computational challenge onto the second and next layers until we understand what [should] happens there.
Anabol 5 120 caps Nutrex - Aumentar Massa Muscular
They could slap on a disclaimer saying 'Results for entertainment purposes only. This service has not been evaluated or approved by the FDA.' I'm no expert on regulatory law but I suspect this would immunize them from most oversight...but I also suspect it would have a deleterious effect on sales.
Important Performance Testing Metrics Explained
Got it:
23andMe Statement Regarding FDA Warning Letter
Published by 23andMe under news

We have received the warning letter from the Food and Drug Administration. We recognize that we have not met the FDA’s expectations regarding timeline and communication regarding our submission. Our relationship with the FDA is extremely important to us and we are committed to fully engaging with them to address their concerns.
The user clearly believes it is his duty to prevent Google from unfairly benefitting from the existence of the question.
In-browser password checker
Absolute rubbish -- the only thing centrally controlled will be the generation of new BTC. That eventuality is expected and after all coins are mined then the reward will be transaction fees.

Up until then, you are correct -- the rate of new BTC generated will be dominated by the few.
>There is a long, long history of other companies and products closing down, too.

Yes but it also natural for human beings to follow: "Fool me once, shame on you; fool me twice, shame on me."
ID'ing hasn't stopped stolen guns from being used by criminals, I highly doubt it will stop hackers from being able to use Bitcoin. Harder maybe. But there will be thousands of markets that exist outside of USA regulation (or black markets within the USA). Especially by the time the USA would be capable of implementing some sort of ID system.

There is also factoring in the complexity added to associating any form of ID to a particular coin, if CoinJoin or similar trustless anonymizing mixing services reach widespread adoption.

This is all assuming Bitcoin continues it's mainstream course.
>hosting your own email could be painful //

In case anyone missed them and is interested a thread on HN recently gave some recipes and outlines for setting up email servers.

https://news.ycombinator.com/item?id=6748670

There are a few in the thread besides the OP.
GTK is often used as the example of what not to do when designing interfaces. A better pure C example would be Wine's implementation of the Win32 API (specifically take a look at user32.dll). Or the Tk toolkit.
I have been trying to find a way to view my old google.com/photos (which used to be picasa), without having to sign up for Google+. So far, have not found a way to do this. They want me to accept terms and 'upgrade' my account. Upgrade for who? Them? Normally, the term upgrade is something the end-user desires. I am really starting to hate Google.
The burden of proof doesn't rest on the person arguing against your borderline phrenological explanations of intelligence.

And yes, faith in humanity IS needed for an enlightened thinker.

The meaning and purpose of life will never be proven. There is plenty of room for faith in our world of rationalism.

You need more art in your life! The world is more than just a bunch of metrics in a spreadsheet to fret and argue about.

We should be skeptical of superstitions, but not skeptical of love, truth, and beauty! Don't misinterpret the quest of the Enlightenment! To listen to love and to live!
And the FDA has been in talks with them since 2009, and with out notice changed its position.
Actually there are rather vicious allegations that some of the ASIC manufacturers do mine with their own designs for some time before shipping them to customers and moving onto hardware rev+1.
We've added a list of the most used performance and load testing metrics just to have a better understanding of the performance application results
When it comes to social media, people rarely "exit" when they're very dissatisfied. A few people do, but most of the ones who are displeased with changes in the service respond by shifting some of their previous uses of it to other services while continuing to use it in different or more reduced ways.

For example, people mostly didn't leave Facebook after getting the message that Facebook is bad for privacy, but in the early days of Facebook I could find nearly every single one of my friends' phone numbers and home addresses on their profiles, and the "phone book" feature was very useful. Now, hardly anyone puts their address there, only a minority put their phone numbers there, and the "phone book" feature is mostly forgotten (I don't even know if they've removed it, I haven't looked for it in a couple of years at least). What kinds of photos people post, and how much they share, has changed a lot over the years, but most of the people who pulled back in this way didn't delete their accounts, and still post material there when they don't care much if it "leaks".

I've observed a similar thing with Google services over the past couple of years. People pull back by shifting some of their activity to other providers, while continuing to heavily use Google.
read the book "The Millionaire Fastlane" by MJ Demarco. after you have read it, your ideas will flow (I think) and you will have a clearer vision on what you really must pursue.
> The post was unlocked a week later by Stack Overflow's robot ("Community"), automatically.

Thanks, corrected.

> In fact, I'm willing to wager that the user flagged the question immediately but it took an hour for one of the moderators to get around to it.

I would hope so, and I thank you for calling this line out, because I forgot one imporant action. As a moderator yourself, you know that the appropriate action once a user rolls back a valid edit to the question is to flag the question for a moderator and move on, which obviously didn't happen. I've amended my original comment.

> What you've described is not at all what happened.

Outside of those two minor points, it doesn't seem like you disagree with my account.

-----

To address the edit you made after I replied:

> No, the user rewrote his entire post to

> > ok i got my answers, we can delete this post now, i am not helping google users.

That sounds like blanking out his question and requesting deletion to me.

> He then added

> > IF YOU GUYS ROLL BACK AGAIN, I AM CHANGING MY NICK TO " ALLAH AKBAR " AND YOU WILL ALL LOOK LIKE JIHAD CLUB MEMBERS OF OSAMA BIN LADEN.

He added that in revision 8, after the power user reverted his question 3 times in less than a minute.

As a moderator yourself, you know that every day users come to Stack Exchange that don't know how the system works, it's a given, and they'll make mistakes. This question did not deserve the treatment it got but this type of thing happens with too much frequency for whatever reason: jaded power users, too large of a review queue, whatever. My point here is that while this looks like "mission accomplished" for a Stack Exchange power user, from an outside perspective, this looks positively kafkaesque.
Just to clarify, yes, I meant exactly that (and that is why I love this place, people actually get it).

And the inputs.io guy is not even close to paying half to what was "stolen". The inputs.io guy was also running coinlender and other services, which are all gone -- including himself.
Have a kid.
Hi, Alan. Regarding CAP, I think that given redundant cluster interconnects, redundant managed power, odd # of cluster managers for quorum, all mean that split brain is just about out of the question, configured properly.

The main reason that I have a FAQ about Hadoop is that I have been asked repeatedly by people, "what's the difference between InfiniSQL & Hadoop?" It seems to be the data project most on a lot of people's minds. It's a fair question, so I created an FAQ entry on my site.

I don't know what Impala or Shark's performance are for transaction processing. Show me the numbers, in other words. I don't believe that Hadoop is going to eat the world, but that it's best use cases are probably in the reporting realm. It seems that Impala wants to bridge that gap between reporting and operational/transactional database--but I can't read from their architectural description just how well it would actually perform for transaction processing workloads.

Regarding Shark, it looks to me like they still see it as an parallelized reporting system, and not geared towards OLTP/operational workloads.

I expect that InfiniSQL will be able to handle quite sophisticated analytics workloads, as more capabilities are added, but they will be more for real-time. I don't see it displacing special purpose analytics environments, especially the masive unstructured ones.

Regarding filtering, aggregation, windowing, I haven't documented it yet. The SQL engine is pretty simple at this point--it parses, makes an abstract syntax tree, then executes. If you need more, then the code is there. :-)
How do we know this isn't an inside job?
> Language is really pliable. It's quite strange that "fuck no" offends only puritans but "uhm... no." can set off fireworks with nearly anybody.

I'd be more offended by the former than the latter, though I wouldn't be all that offended in either case.

> I guess we all just have to adapt.

I agree, if by adapt you mean we can all just chill out a little and be better listeners. I think the graph of grammatical and punctuation expectations is growing a longer tail.
But it has Zope in its name!!!111!! ;-)
I feel like you're banking a little too heavily on external measures for error protection/durability like UPSes and ECC memory, rather than embracing the inevitable fact that corruption and failures will occur. In short, I'd really need to see a white paper on why you're not reinventing the wheel before I'd use InifiSQL.

Kudos for engaging the community though; please do keep us posted as you progress.
Is that true? It sounds like a crazy privacy issue, so I would be surprised. But maybe I am too naive.
I've heard of DDoS attacks used to divert the admins attention while a real attack is occurring. Also I know packet flooding can cause some network hardware to switch into a lower security mode in an attempt to handle the load. I'm not sure if either of those apply in this case, though. I definitely am not a network or security expert.
Like anything that is brand new and cool, it's only available for US residents. :(
You mean if a company has started 10 products in its lifetime, it should close down those 10 products and also 2 other company's products?
The Meritocracy Myth
Funnily enough, in the dev team I'm in, we build "11" factor apps, which keep the code in a git repo. I build a lot of django apps and use the idiom at the bottom of the settings.py that looks like:

try:

from local_settings import *

except ImportError:

pass

We then have dev_settings.py, local_settings.py, and qa_settings.py in the code repo. The deployment system will copy ${env}_settings.py to local_settings.py. So... assuming you aren't using something like zookeeper (or etcd if you're more bleeding edge), I 100% agree with you :)

This is why I say my team builds 11 factor apps :)
In defense of High School football and younger, most of the players aren't physically developed enough to cause and long term damage to themselves or anyone else (in terms of head related injuries). College and pros is another story. That's why as you get farther along in your football career the less you have full contact practices. In college (and I would bet my hat that it is the same for pros) sometime around week 2 you are pretty much done with full contact hitting in practices (their might still be some hitting at 75% speed to work on form).

I played football in college and I think they managed the players' health pretty well. Granted I was at a smaller less competitive D3 school but, all the same, I never felt fear that I was going to suffer any long term head injuries (also I never got a concussion in 8 years of playing).
It would be sort of nice if VPS providers did this. I sometimes find it difficult talking to non-technical people about Heroku or Linode and they look at me like "I've never heard of those, can't we use GoDaddy?"
Rock on.
Having a 1 or 2 micro habits to act on, that often infect other aspects of your health, is a must. Those targeted behavior hits should be at the top level of your personalized report. Now getting people to follow through, week after week, month after month, year after year = a tough human problem.

Side note: We have an analog mechanism for daily behavior change, due out in Spring 2014 ... the Health Axioms: http://www.healthaxioms.com.
You can if your desktop is ChromeOS
And if you had of replied with the tone you used here, it might have come off a lot better than it did.
Non sottovalutiamo l’oro blu
"Are we're all so afraid of our own shadow that heroes at the FDA need to protect us?"

Well, yes. You can try to make it look like a bad thing by using loaded language, but yes, the whole point of the FDA is to protect us from problems like this.

Medicine is complicated. It's also a very poor fit for free markets, because it tends to be filled with monopolies and because free markets require informed participants and the extreme complexity of medicine makes that impossible for most.

Historically, large numbers of people and companies have had no compunctions with taking advantage of this to defraud a lot of people, frequently while causing them pain or death. The FDA is intended to fix that. It may not succeed, or may not succeed well, but yes, this stuff is dangerous and we are afraid of it to the extent that we want an agency to protect us.
The numbers I've seen suggest that condos on average actually appreciate more than houses even in a given location http://re-sanfrancisco.com/10-years-of-san-francisco-condo-v...

But I'm not sure how much you can conclude from that as a condo could still appreciate (i.e. someone would be willing to spend more money for it) even if the underlying physical plant were deteriorating at some rate. It's probably also worth noting that, in a lot of cases in the US, single family homes in particular don't necessarily deteriorate. People do maintenance, redo their kitchens, add decks, etc.
He's PHP "developer", figures.
It's getting pretty infuriating the direction they seem to be taking on this. I would gladly be using the wallet app without a card, KitKat on my Nexus 5 has it baked into the settings even, but Google seem to have no desire to put it out in the UK.
I finally managed to do this almost a year ago. Really, this comes down to understanding (and accepting) that your body is built for adaptation. The more steadily you feed it regular inputs, the more it will embrace those inputs and come to expect them.

- Force yourself to wake up at the same time every day -- no sleeping in on weekends.

- You should know roughly how much sleep you need in a night, and arrange your life so that you can get in bed X + 1 hours before the time you want to wake up.

If you can't do these two things at least 90% of your days, you won't succeed. Later (2-3 months later), once you've established your pattern and are well adapted to it, you'll have a bit more flexibility with your schedule and still be able to maintain it.

A few things that helped me accomplish these goals:

- Exercise (cardio) first thing in the morning. You will find yourself getting sleepy much earlier in the day. Don't exercise at night, as the endorphins can take several hours to disperse and will keep you awake until then. After about three weeks of morning cardio, your body will begin to adapt the timing of your energy cycles and you will find yourself springing out of bed ready to run. I have used this to my advantage to replace my "night owl" tendencies with "morning person" tendencies on the days off from the gym. I also find it more productive, as my mind is fully rested.

- Melatonin. Presumably, you're staring at a screen of some sort many hours a day like most people on HN. Blue light inhibits natural melatonin production, so to compensate, take a melatonin supplement 1-2 hours before you intend to actually fall asleep. (You should experiment to find out what the lowest dose is for you which still helps you fall asleep.) Also, turn off as many room lights as you can at that time, and dim any screens you're viewing.

Like I said, it can take a few weeks to initially shift your schedule, and a few months to fully adapt to it, but it can be done if you're dedicated. Best of luck.
Right, they're used as distractions fairly often. The rest of the explanation makes no sense though; that is, I don't see how the DDoS would then "make the system vulnerable" to Bitcoin theft. Unless it was something like where the attackers already had access, but most everything was kept in cold storage and they wanted to force them to move a lot of BTC into their live wallets.
If you want to read answers from the Stackoverflow moderators(or Diamond users as they are called) you might want to check the discussion on meta.stackoverflow.

http://meta.stackoverflow.com/questions/166623/what-is-a-day...
US regulation is weird. Stuff that is wildly not compliant to modern standards is grandfathered in, while stuff that in many respects meets MORE stringent standards (e.g. anything sold in western europe) can't be registered.
For me, it's not based on the work, it's based on the mood/mind. A "good day" is one where I was thinking clearly and solving problems and choosing good paths with ease.

The amount of code written doesn't mean as much.
Dropped: porn and reddit (though I'm still on HN obviously)
1.
http://scifi.stackexchange.com/questions/16722/why-does-tywi...

Arya Stark: My mother served Lady Dustive for many years, my Lord. She taught me how to speak proper--properly.

2. "English" is capitalized.
Falcon 9 GEO Transfer Mission [video]
Simple FizzBuzz test would suffice imo.
The meaning of that is self-evident - you could be discriminated against because people considered you to be untrustworthy due to the results of the test mentioned in the preceding sentence. Where you and crusso see political correctness - perhaps in the belief that I'm describing such a test as a proxy for some identity group - what I'm actually concerned about is the accuracy and/orpredictive power of such tests. I really doubt that you would be OK with finding yourself on the receiving end of such an evaluation.
One of the pretty cool things is that Rack'em includes a web server utility for running applications locally.

Also Rack'em is technically Rack compliant, so you could literally run a Rack'em application with a Ruby web server.. Yes, crazy, but the unification is great. Why re-create the wheel with more specs and standards when the Ruby community has already created one that works?
What is the legal precedent for this?

Adblock has been able to fly under the radar because it is used by people who sought out a way to block ads, a minority of internet users.

MegaKey replaces ads (something that is more likely to piss off advertisers more than removing ads) as the 'cost' of downloading free music, something many consumers are interested in.
If you've got the freedom to design your calling convention, you don't need trampolines or anything like that.

The basic idea is to compile every call in a tail position to a jump. You just need to clean up your stack before making the call, and make sure to arrange your calling convention such that A can call B, which can jump to C, which can return directly to A.

In the A -> B -> C example, this means:

1) Using a callee-pops convention so that callees pop arguments off the stack rather than callers. If B and C take different numbers of arguments, A doesn't know how many arguments to pop. So functions should pop their arguments off the stack themselves before they return.

2) B must restore its callee-save registers before jumping to C, which will save those registers itself if it clobbers them.

3) To accommodate variadic functions, there has to be a hidden argument to let callees know how many arguments were actually pushed by the caller, so they can pop the right number.
a very good idea
I did some analysis and I found out that roughly 1/8 of the delete questions on Stackoverflow are deleted by the author of the question.