skysight-inc/HackerNews huggingface dataset:
It obviously is possible to evolve resistance to soap and hand washing: It doesn't kill us.

But the gap from a bacteria to something that can withstand the physical barrage of a thorough wash is huge in comparison to the relatively tiny changes to overcome some antibiotics. E.g. an antibiotic might disrupt a single process of the bacteria that is beneficial (for them) but that have a multitude of similar alternatives that are different enough for the antibiotic to fail. Compare that to even just being able to strongly enough attach to the skin to not be flushed away by sheer force from a wash.

There are many reasons that tends to be given for being careful about stronger measures: 1) it is not necessary. It's a matter of being cautious - by using the least effective means that is effective enough, we exert the minimum pressure necessary, leaving us with a larger arsenal of (to us) gentle alternatives to step up to. 2) the stronger methods, the more we kill off beneficial or neutral bacteria too, and by doing so we may make conditions better for bacteria that are nasty for us if we happen to pick them up.
3) we reduce our immune systems exposure to relatively harmless amounts of bacteria and some believe this may be sufficient to actually reduce our overall immune defence.

As DanBC pointed out in response to one of my other comments, there's also the issue of physical damage. While we can bring the heavy artillery and effectively kill anything that lives on our skin, we can as collateral damage cause damage to our skin that creates additional places to hide - effectively a worse variation of washing away good/neutral baceteria - not only may we be removing the competition, but we may be opening cracks and folds that'll be excellent hiding places.
"where to get off" has at least three interpretations---the one you note, one in which you insulte the Parisienne (why a Parisienne? Why not the English word, which has the advantage of being gender-neutral, "Parisian"?), and the (presumably) intended interpretation, what exit to use.
Cannabis is currently illegal. This means that some of the people involved in growing and distributing cannabis are vicious criminals. This includes some of the Mexican narco gangs, and in the UK includes people who traffic illegal immigrants into the country and force them to work in grow farms. (Here's one example, but there are more http://www.chroniclelive.co.uk/news/local-news/illegal-immig... )

Any cannabis related service would have to risk-assess that kind of involvement.

And any attempt to create a "nice" market - avoiding that kind of exploitation by having small growers providing small amounts to locals, avoiding the associated criminality and restricting service to those over the age of 21 would be destroyed by The War On Drugs.

"We" might think it's a good idea, but plenty of people would call it Evil and get support for that viewpoint.
Is Your Door Really Always Open?
> we should be secure against irrational attackers too

Right, of course it would be better to have something indestructible. But so far it's "good enough" (passes the reviews of its individual components, has resisted for years as a system, but wouldn't resist an irrational attacker). And I much rather have this than the previous system, which is insecure by design (ie: your funds can and are systematically stolen through inflation and other means). Maybe you live in a very good country, where you don't have to worry about such issues (or you live in a regular country but are just not conscious about it?). But most of the world (including myself) doesn't, so Bitcoin is welcome as is.
Incredible. I just went through the FAQ.

I would say this is going to be a really really hard sell for most people. The instructions scare me more than anything else. They are written in such a way that it tries hard to not mention explicitly that LinkedIn effectively another gateway between the email provider and you.

I just don't get it. How do these companies just assume privacy is a non-issue and come out with products that just completely assume people will trust them because they have a cute privacy statement - "please trust us, we will never do anything with your data.".

I'm sorry LinkedIn. This isn't the Facebook crowd. A lot of LinkedIn is IT and I couldn't imagine the average LinkedIn user using this product.
The problem for me as a potential user is that I no longer trust some.random.dude.com with my CC info. I have no way to know if they're storing it locally unencrypted or if they're using a trustworthy third party provider.

I'm down to maybe three places that have my CC on file. Everyone else, I enter it - every month - at time of payment. I don't exactly like this, either - there is still the possibility that a poorly written component is logging the card somewhere[1], but it's better than handing over my wallet and walking away.

[1] seen it...
Personally, I've been hoping for an open Sublime Text, so this is pretty interesting to me.
Back before there was a graphical "web" and all the rest, and when typography was generally relegated to a small subset of professionals, I learned quite a bit from Don Knuth's (yes, that Knuth) TeXBook. He's an entertaining writer, as well, and it was an enjoyable read.
We designed the `serf` library to be able to be easily embedded, so hopefully it can be of some use. Unfortunately Serf does not make use of any sort of NAT traversal currently. We've open sourced the project hoping to get the community involved, and NAT traversal is something we'd gladly work with the community to get implemented.
Been thinking about this for a long time, glad to see it's a reality now. I'll absolutely download it
Breaking Away: Why Several Top Public Universities Are Going Private
> And this is the way forward to developing new antibiotics.

I personally think there is much potential in Phages in the future. It has already show to be one of the ways to go fighting resistant bacteria.

https://en.wikipedia.org/wiki/Phage_therapy
Good points. If the OP could navigate the nightmare and still make a good profit margin, I'd say it's worth it.

Perhaps a risk is black market weed selling for less enough than legal weed that a legal profit can't be made.
super stoked for this team. trajectory: upwards and onwards.
That would be my preference. And contrary to what others thought that one would want a lot of these loops, when you want only a few, especially when those few are fixed for the entire program life you can do better by avoiding malloc altogether.

Could be my preference for working on systems that never malloc and only use specific pools and rely on knowing their exact memory requirements from the start to the end. I can acknowledge that this may be more anal than normal but then if the library didn't allocate in my name I could choose to allocate on heap or use it in a static fashion as I please.
the price for sending out an SMS is technically the same for the trial account, but you won't be paying for it :)
You could be right, but have a read of the review I linked above, search for the text I quoted, and read around that. To me, it's compelling that the iPhone 5S's GPU is severely underclocked, leaving headroom for reuse in the iPad 5. And of course higher-clocking is usual in iPads, with their larger battery.

BONUS: for next year, the G6630 gives 50% performance increase + the expected node shrink allows a further ~30% overclock. 1.5*1.3 = 1.95 ~ 2.0.

For the following year, they could go for G6630MP2 (the 6 clusters can be multicored as a whole). Next (three years from now), they could go G6630MP3 plus another node shrink. By that time, there could be 8/10 clusters available G6830, G6A30 etc, and an entirely new architecture in the works, though probably not yet available.
This is what I've been looking for since the iPad came out. Your brushes aren't as good as Paper, but the zoom feature is killer and makes the iPad a real drawing tool for the first time.
Borussia Dortmund reveal limit of Arsenal's revival in Champions League clash
What the Front Page of Hacker News Told Us
I think you misinterpreted.

It seems to me that he's saying that he sends reminders that the credit card will be billed and people don't cancel. But as soon as they get emailed that a charge was made, they do see that email because they're quick enough to cancel and request a refund.

It sounds to me like OP is actually going a fair job of managing this. He sends notice before billing, and a receipt after. Though I might change it so that the first billing required an opt in, with daily reminder emails in the last few days.
Pixemlator is positively awesome, one of the highest quality + polished native apps I've used, at insane value! It quickly became my primary graphics editor of choice.

Though it's weird that I bought a copy years ago and am still getting free upgrades? I'd happily pay for an upgrade again.
They should add "from the folks who brought you Vagrant" to the top of the homepage.
Websites for Nevada brothels exist.
Unless I had full-on born in the US grade citizenship, I wouldn't touch it. The US legal hassle plus the arbitrary nature of border guards makes this an absolute non-starter.
Suffer the same fate as Flash?

The fate of sustaining comfortably for more than a good decade you mean?
If C++ is so bad, what should game developers use?
For example, is C# really a good choice when developing on Mac or Linux?
C is too low-level.
With the development of generic anti-virals like DRACO ^1 - http://web.mit.edu/newsoffice/2011/antiviral-0810.html - I wonder if we might see viruses become largely treatable even while bacterial infections are becoming less so.

^1 who names these things and are they purposely trolling conspiracy theorists?
Remember "Google buys Sparrow"? I wonder if we'll see "Adobe buys Pixelmator" in the near future.
This is actually very cool and is something incredibly handy for managing failover/membership.

What I unfortunately don't understand is that there doesn't seem to be a library I can use to take advantage of this in my own application. If I have a program (in Go) am I expected to spin up my own serf process then communicate with it via socket? Is there an option for me to have serf live inside my application?
http://www2.costco.com/Pharmacy/DrugInfo.aspx?p=1&SearchTerm...

30 pills - $5.90. So a normal cycle would be about 3 dollars. In the United States. Antibiotics are so inexpensive.
There is a catch here however, any resistance a bacteria has, has implicit cost to the bacteria in the form of copying the resistances' dna into new cells. This costs the organism energy and time to copy. If it confers no benefit it will be dropped from the genome.

I really recommend everyone here read Power, Sex, Suicide, mitochondria and the meaning of life. Amazon link (no affiliation/referral) http://www.amazon.com/Power-Sex-Suicide-Mitochondria-ebook/d...

Bacteria both evolve resistance quickly, they also lose it just as quick. Because unless it directly is needed in the here and now, the bacteria that remove it and survive without it outcompete the rest of the bacteria.

This is my understanding at least, a real bacteriologist can comment what I inevitably got wrong. But the recent study that used existing antibiotics in a certain way to kill bacteria is a great demonstration of bacteria not being able to select for all simultaneously and retain the old resistance in the future.

I'm not overly concerned about bacterial resistance given there are ways we can work around it.
Thanks! Even at 120 pages you crammed a lot of information into a short amount of time and pages. I appreciate what you're doing.
His product will only take significant business from ST if it is better. Within reasonable bounds, the price of an editor is not going to be a deciding factor in the professional developer market.
This is amazing evil app, with great business value. Every time i log in to web app they want to get my connections from oauth. And now the app will be "see" every my mail and addresses.
Cannabis isn't illegal everywhere. Washington and Colorado legalized it recently, and other states will likely follow in the future.

Not to mention that Cannabis is legal as a medical treatment in many states.
Then we can tug on gravity to send signals instantaneously!
You nailed it. Standards are nice and all, when they're perfectly unambiguous, and when everyone follows them exactly. That is not the real world. Writing code clearly and explicitly has far more reward for the effort put into it than learning all the standards pedantically.
Nevada brothels are legal. In fact, they are highly regulated.

http://en.wikipedia.org/wiki/Prostitution_in_Nevada
Some theories regarding optimal syllabic structure would point towards the hard "G" pronunciation.

For me, personally, "jiff" (a la "Jif") is peanut butter. "gif" is, by contrast, a distinct sound that doesn't overlap with anything I already know.
TCP uses RTT time to try to guess network congestion. Having worked on software that almost always had satellite hops, it sucks on long links. Primarily what you notice is that you get limited bandwidth because the TCP stack is throttling to prevent congestion. Not sure what RTT is to the moon and back but you would want to use something like TCP Hybla that does network congestion control a different way.

http://en.wikipedia.org/wiki/TCP_congestion-avoidance_algori...
Turn your Bootstrap template into a PHP driven site with PHPstrap.in
Are there federal laws against prostitution or is it merely a state matter?
A very cool idea - definitely an app I'll be downloading once I finally purchase myself another iPad.
A Firefox phone is going to be on sale here in Uruguay soon too (sold by Telefónica Movistar):

http://firefox.movistar.com.uy/Content/Images/invitacion_Fir...

http://firefox.movistar.com.uy/Register
IPad Mini Retina vs iPad Air
LinkedIn Intro: Doing the Impossible on iOS
Tmobile just stabbed wifi-only devices in the heart. The slow painful death of wifi only starts today. Soon LTE will be as standard as a Wifi
It's the perfect place to bootstrap a small not-technically-a-startup-by-certain-definitions company, though. Fantastic place to live, still quite cheap, etc.

It's close to the ideal environment for an indie games studio, for example. Not looking to make massive piles of money and scale to infinity, just explore creatively and grow slowly.
I can save my settings in JSON but that is not ideal as I have to keep track of that. It would be better if site saves that on the server.
The Serf executable is actually just a wrapper around the `serf` library. That library is designed to be embedded in Go applications. Documentation for the library is available here: http://godoc.org/github.com/hashicorp/serf/serf
What if your startup is a small shop in CO or WA? Not every startup will grow to be nationally known.
Why You'll Take $6k Over Better Health
Google testing sponsored cover photos in SERPs
Prostitution is not illegal under federal law, only under (most) states' laws.

Marijuana production / distribution / etc is illegal under federal law. The DEA (a federal agency) could come after you -- and would, if you get big enough -- even if it's legal in your own state.
There are actually studies being done around implementing exactly that with antibiotics... However there is also the fun danger of your skin turning incurably silvery blue thanks to the silver component in the antibiotics... No really.
Wait, so I can use this API to send free SMS messages? The limitation is that I'm locked down to 1 phone #?
Google experiments with giant banner ads on top of search results
I wouldn't mind taking a closer look at that. They do have a data API to store individual key value pairs http://snapsvg.io/docs/#Element.data

Definitely different than what I'm used to in D3js, but worst case scenario you would have to loop through each key value pair. Worth testing out.
>> Cannabis isn't illegal everywhere.

Well that's the first problem I thought of. The federal government maintains that it's banned at that level, and that's still an ambiguous conflict that no one's really confronted directly yet. Some local / municipal governments have also banned it inside these states, often only a short time after the state legalization.

The reason I wouldn't do a cannibis-focussed startup is because it seems impossible to predict how you might negotiate this legal terrain. Can you count on your town not to make it illegal again? Can you count on how the state vs. federal disagreement will be resolved? Can you deal with such inconsistency between towns if you have a broad client-base?
The best opportunity in this industry is selling the pick axes to the gold miners. The marijuana industry will need a lot of infrastructure. Just look at all the regulations. For example, there is a lot of tracking involved. So maybe a startup could focus on tracking inventory for dispensaries. But the point is that you can make money here without doing anything illegal. Just build the infrastructure for the people who are selling the weed, and once it's legal, you'll be in a great position.
Learning an editor is an investment in a developers time. Software has to be updated and maintained to work on newer operating systems. With popular open source editors, you're pretty much guaranteed that the software will continue to evolve. Can't say the same about proprietary editors. I think a lot of developers could use an open source editor for their entire career, something highly unlikely to happen if they were using a proprietary one.
Don’t Build Your Startup Outside of Silicon Valley
Thanks! Is there something similar for Java?
Canada is a whole new ballgame for Cannabis startups.

Prime Minister Harper announced that legalization is coming in the next 10 years, tops. We have 6 months before the new regulations are in place, which open the floodgates for corporate cannabis providers. We're currently in a cannabis gold rush right now, so I figured this would be a great time to start a Cooperative that courts illegal growers into becoming legal ones, if just to prevent clogging the courts with people trying to produce medicine for sick people.

We've gotten a lot of support from Health Canada, too, as it seems that there's a massive contingent within that's unhappy with MMAR (the previous regulations) going away. We haven't even sought outside (public or semi-private) funding yet, because we haven't had to. :)

we have a website with a fantastic (imo) domain name, but we're keeping it quiet until we're closer to launch. hoping to pimp it here when it's ready.
Indeed; ~half of the technologies listed in their splash image for the "New Image Editing Engine" are Apple-specific: vImage, Accelerate framework, vDSP, Core Animation, ColorSync, Core Image, ...

Some of these have rough equivalents on other platforms, but the interfaces definitely don't line up exactly, so it wouldn't be completely straightforward to shim them. Others simply don't have existing equivalents.
Ask HN: the cost of filing DBA vs LLC in California?
We are currently developing my startup and it's almost done. We are bootstrapping at the moment, so we would like to keep the cost down as much as we can. We are located in California, and I have been reading DBA vs LLC.

Obviously LLC would protect you more, but I think it costs more to file LLC? While DBA costs way less, but it is basically just a DBA without any protection.

I am thinking of doing DBA first just to see if there is any traction for the startup, then if it has some traction, then I move to LLC. I intend to do it myself vs a lawyer for a DBA

Is this a smart move? Should we just go LLC right away? What is the lawyer cost to file LLC ?

Thank you for the advise.
JetBrains makes a free version of its Python editor
Living in SF means
Intellectual Ventures ramps up lobbying in face of new legislation
The moment we start calling things "the jQuery of..." we're no better than startups that are "the Facebook of..." :)
Apple Crosses Its Hardware Rubicon
@tehwebguy Yes, that's right. We want you to use Plivo to the fullest.
I use Sketch almost exclusively for iOS UI design now. It has its weak points (most specifically relating to undo), but I find it much easier to create pixel-aligned icons than anything else.
Without going into too much detail, I did found a MJ based startup, however I ran into 3 big problems:

1. My startup focused on fostering relationships with producers and distributors, both of whom are hesitant to openly discuss or display their business, location etc in a way that can be easily accessed publicly.

2. Legal fees. I tried to set up everything as legitimately as possible through a lawyer as well as keep him on retainer in case I ended up in any trouble with the law. Massive overhead.

3. Saturation and fear. At the time of my efforts there were two major shifts in the West Coast market. The first was a flood of growers both indoor and out that greatly reduced the value of anything that was not of the absolute highest quality. The second was the crackdown on many major players in the game; people saw that old names in the MJ industry were getting raided and prosecuted and started to either withdraw or severely limit their business relationships.

Basically until everything is legalized at both the state and federal levels it will continue to be very difficult and expensive to try to revolutionize this industry.
This humorous observation does not affect the argument, it just derails it. It's easier to make money off drugs for chronic conditions than for one-off infections.
> is C# really a good choice when developing on Mac or Linux

No, not for game development.

And who is saying that C++ is so bad? It is a really powerful language with lots of libraries. If you already know C++ then I think it is a natural choice to use it for game development.
Right, the article was saying that. But the article was jumping to an unreasonable conclusion, because of course you never hear from the people who missed the "Billing receipt" emails.

I assume that was GP's point.
Why developers are like artists
http://www.newscientist.com/article/dn3232-first-speed-of-gr...

It is.
Video Backgrounds Free | Flickr
I'm really excited that we've made it to this point. The implementation of the full JOBS Act has been on the horizon for over a year and I think it has a lot of potential to do good.

That said, I'm nervous about overzealous regulations. There are a few ways this can create severe enough adverse selection that healthy, high-caliber companies will avoid raising from the unaccredited crowd.

I'm still reading the details in the 585 page PDF of proposed rules but some concerns come to mind:

- Capping the whole round to $1m
- Forcing unnecessary financial disclosures
- Inability to use a single purpose fund for aggregating small investors (forcing every unaccredited to be a direct investor)

I believe these are all feel-good but destructive rules that will poison the unaccredited crowdinvesting ecosystem. At Wefunder we've learned a lot about what it takes to get high caliber startups to use our platform and I'm pretty confident that those three things can each be deal breakers.

If you're a part of the startup ecosystem I encourage you to pay attention to this law, get informed, and give the SEC your feedback. These are only -proposed- rules and the SEC will listen and adapt (at least, they have in the past). Someday you may want to raise money or invest in a company!
That's funny…

There will be no banner ads on the Google homepage or web search results pages. There will not be crazy, flashy, graphical doodads flying and popping up all over the Google site. Ever.

http://googleblog.blogspot.co.uk/2005/12/about-aol-announcem...