skysight-inc/HackerNews huggingface dataset:
Very, very cool. It "feels" great to use it - the lines look smooth and satisfying to draw. I can see this being a lot of fun to use for random doodling. The simplicity is also great - it does exactly what it needs to, and no more.

Only one problem: I have zero artistic talent or ability. I've often wanted to start practicing drawing, but it was never THAT high a priority, and I never put in the effort to get a pad, pencils, start carrying them around with me, etc. An app like this can make it close to zero effort to get started and to doodle something every day.

Now there's still the problem of guidance or knowing where to start. Give me something like daily challenges or tutorials - can range from something as simple as "here's a picture of a cat, draw it" to more advanced animated tutorials - and I could see myself getting hooked. I would not mind paying for "content" or for a monthly subscription under this model.
This is probably outside your vision for the product, but adding a text box tool would transform this into a pretty amazing notebook app. All the type-and-draw apps I've used are locked into the physical concept of a page, and combining a ZUI with art tools and text would be a delightfully organic way to take notes, build loose wireframes, or annotate concept sketches.
By that logic, we can't hold people responsible for electing idiots.
Bitcoin is money. Bitcoin is a bubble.
Russian nesting campaigns.
If you are looking for somewhere to craft regexes, someone recently posted a link to a neat looking project, regex101 http://regex101.com/ .

This link looks to be driving traffic to this myezapp.
No iOS apps require a special pen.
I've posted this before, but some people may have missed it.

"Defeating the superbugs" (http://www.bbc.co.uk/programmes/b01ms5c6) has a segment showing bacteria developing resistance to antibiotics.

(http://v6.tinypic.com/player.swf?file=24goih4&s=6) (Sorry about the lousy host; YouTube's content sniffing detects this as BBC property and blocks it.)

They have a slab of nutrient jelly. The jelly has sections of differing strength of antibiotic. There's a section with no antibiotic, then 10x, then 100x then 1000x. (They cannot dissolve any more antibiotic into the jelly at that point, they've reached the limits of solubility)

They drop a bit of bacteria on the zero antibiotic section.

A time lapse camera shows the bacteria growing, and developing resistance to each section. After two weeks the entire slab, all sections, are covered. The bacteria has developed resistance to the antibiotic, and is resistant to antibiotics at a strength that could not be used in humans.

It's an excellent, scary, bit of video.
This is not at all how drug development works.
Doesn't explain why Apple gets praise (most closed of them all). I think it's more of a hype/image issue.
I am very impressed with this and for $30! Giving photoshop a run for their money!
I'm using a late 2011 MacBook Pro and it took about 60mins - but then it stuck on 'one minute remaining' for another 45mins. Still, I can't complain that's still pretty impressive imho.
Simple, Cloud-Based Payroll App
And not to cure diseases: http://www.ucsusa.org/food_and_agriculture/our-failing-food-... (slow site warning)
> "Why isn't it economically feasible to create new drugs for them? "

It's not that you couldn't make a profit off them. It's that the opportunity costs can't be justified (today).

There's a finite amount of R&D funds available to any firm. And if I'm maximizing profit, I'm not going to spend my money on difficult research, seeking and developing a drug useful to a handful of patients in 4% of hospitals, that's taken for a few weeks by each patient.

Not if I can instead spend it tweaking known drugs, useful to 30-50% of the entire population, that they'll take for the rest of their lives. (e.g. blood pressure medicine)

And particularly not when CDC, WHO, et al are actively campaigning for changes to antibiotic handling/prescription/use which may well mean your potential future market for "a better antibiotic" is actually smaller than today's.
I submitted this a few days ago about future alternatives to antibiotics. Maybe it's more interesting now?

https://news.ycombinator.com/item?id=6559134
That and "you can get an astonishingly long way on nothing but gumption". Can you honestly say that the Wired shoe story didn't make you smile? Not even a little?

He seems like an interesting guy, and I hope his mystery employer is channeling his energy in useful directions.
The Farmer, the Food Truck, and the Foodie
Apple hasn't been charging for iOS or the software that ran the first iPod. It's included in the cost of the device, just like the cost of the embedded code in your Keurig is factored into the overall cost of the device.

Software isn't where Apple makes their money. It never was. They NEED software to make their hardware do anything but that's all they ever should have considered. The many years of rivalry with other OS makers was stupid and costly. They weren't really in competition.

You get a free copy of OSX with every Apple computer but charging for OSX upgrades only makes the job of keeping all that hardware running smoothly more difficult. It generates avoidable support calls and support is a huge cost.

If the software (they have to write anyway) is free and hundreds (or thousands) of bug fixes are always just a free download away then everyone benefits. Apple can stop focusing on feature parity with other operating systems and focus on what makes their devices better for their users.
That may be the only way, I agree. But because open source
pricing fails to capture the value of the software, you'll make 100x more writing closed source software for a more respectful industry.
Possibly a big part of this fast adoption is that you can upgrade to Mavericks from previous OSX releases - you can skip over Mountain Lion, etc. So a lot of the people who never paid to upgrade their OS before can now skip directly to Mavericks and get all of the previous OS improvements for 'free'.
I think paper is the best medium for any book with even slightly complex formatting.

I have bought many technical books on Kindle but now I am realizing that Kindle is not suitable for technical books especially when there are a lot of side bars, code snippets.

I don't like reading on ipad or laptop though. So I have started buy print versions of most technical books.
Can anybody spread some light on the business model they are trying to follow? I know they sell software, but with a single software for $29 and few employees. They need to sell quite a few licenses to make it.

I know its an ignorant statement, but can anybody explain it to me.
I haven't read Authority yet, but it is on my to do list. I did do most of what they suggested in this article though for my book[1] except one thing. That is price it high and do multiple packages. I think my biggest mistake was having Amazon as an option because that limits me to selling for $9.99. It hasn't been a total failure, but it hasn't made the ~5k these examples did, and I'm pretty sure pricing is the biggest reason why. I suspect most of the people who bought it at $9.99 would have also paid a higher price, especially with additional resources in a package.

[1]http://buildanappbusiness.com/
They renamed the icons. They don't just break apps when they do that, they break users. At some point things like the names of icons should be frozen. I love Font Awesome of course. But please!
Plasmids are only one of the ways that bacteria adapt.

Adapting antibiotic resistance can take as little as a single nucleotide mutation in the right part of a bacterial genome. Many of the known antibiotic resistance mechanisms involve small mutations to critical proteins.
In Denmark, they prevent infections in chicken houses by thoroughly cleaning them, then using techniques developed for clean rooms to prevent infections. In the US, we let them wade in their own filth and pump them full of antibiotics. We should just make it flat out illegal to use antibiotics across entire herds of livestock. We should also fine doctors for prescribing antibiotics to patients with a viral infection and no sign of bacteria in their systems, unless they are severely immune compromised.
> tools of last resort only to be used in emergencies, with great hesitation, and only when absolutely necessary.

Really? And whose lives are you willing to play that game with?

Your 8 y.o son, who just broke his arm and has new swelling three days after the arm has been set?

Your wife, with a bladder infection so severe it's bleeding and she has a fever?

"Sorry, son - your suffering is for the betterment of mankind. I'm pretty sure you'll survive."

"Sorry, honey - let's just see if you can make it another week or two."
>you'll buy drugs for high cholesterol the rest of your life

Not if you get killed by an infection first.
I would hope the average reader here is capable of utilizing http://www.downforeveryoneorjustme.com/ or their own terminal to determine if a site is down.
Interesting; have you more detail on that system?
In my opinion each "family" of languages provides interesting lessons for programmers who learn them.

For learning the high level concepts of programming I think that languages like Clojure, Haskell, Python and Ruby are best. They allowed me to easily play around with complex libraries and technologies. This helped me learn about how to evaluate and integrate others code into my own, they also introduced me to many concepts that I don't think I would have studied had I not chosen to learn the language.

For learning the elegance of programming I honestly think Javascript is the best. Some might disagree, but because of Javascript's weirdness and inconsistencies when I came across a really elegant solution, it really made me rethink the process I use to program solutions. I also learned a lot about "elegant" programming from reading and learning about Haskell and J.

For learning about the lower level mechanics of programming, I think that the C/C++. The languages are less forgiving and it forced me to think about the repercussions of my sloppy code.

I'm curious to know what others think.
Twitter Quietly Doubles Board Compensation
"Designed for" isn't "requires". It was designed to be compatible with Bootstrap, but that doesn't preclude it from playing nice with other frameworks.
Hm... I like that tactic because Apple probably tested tablet sizes like crazy, so they can expect their size to be comfortable. Why does it matter what people will be carrying it with and how many of their notebook-loving customers really have iPad minis?
I've been hearing about the coming Antibiotics Apocalypse for some time now, and while it sounds very dangerous I'm wondering what signs to look for about how bad it's getting. Articles like these point to limited things like an increase in MSRA outbreaks or vague statements about increasing infections from hospitals, but it's not like average people are dying in the streets or anything. How do we tell how much we're moving on the long continuum from here to there while keeping isolated stories in the larger context of overall antibiotic resistance?
Folks on Android might want to check out ScribMaster:

https://play.google.com/store/apps/details?id=net.thoster.no...

Can't say how it compares to Sketcholgy (not being in the target audience) but it exports and imports SVG and also has what seems to be near infinite zooming.

You need to buy the full version (US$2.00) to get all the features but the free version is still quite nice.
Fun fact: modern plastic surgery -- including purely cosmetic, non-normative surgery -- predates both antibiotics and anesthetics.
Oy I didn't see that. Oh man.
Why is it easier to transmit from the moon to earth? Here we have more power and larger/better/faster/more tuned lasers than the space vehicle does. Seems like getting earth's transmit rate way up would be relatively easy while getting the vehicle's transmit rate up would be really really hard.
I'm in the process of writing a book right now (http://yourfirstwebapp.com) with the help of Nathan's Authority, and I can say that his book is jam-packed with useful info. It's been particularly beneficial in helping me develop a cohesive plan/strategy to plan, write, and market my book.
Check out the demo: http://quarnster.github.io/lime/

Looks Interesting!
I heard the author on NPR yesterday. I think it's all very true, but it seem disingenuous to blame antibacterial soaps. I haven't ever heard of human antibiotics being added to soaps. And I don't think a triclosan resistant bacteria would be of much risk to us.

The only argument I can think of against antibacterial cleaning products would be that our bodies get less exposure or "practice" against ordinary bacteria?
1. My impression was that Apple has had a couple flat/lower year to year quarters in lap and desktops. Their chart of iPad sales shows slowing/maturing of that market segment.

2. Apple sells experiences. If it were selling devices, then software updates for older devices (other than bugs and security/safety) would make no sense.

3. Giving away iWork and iLife is an interesting move that starts building a moat of out-of-the-box productivity software and somewhat incentivizes new sales without totally pissing off previous software purchasers (thru iTunes rebates) and acts as a stronger introduction to their cloud services. It'll be interesting to see if that strategy works enough to continue development on iWork (which I enjoy using although acknowledge is a not widely used product).
icomoon.io

It doesn't have the 10 new version 4 FA icons yet - but you can add any svg based icon you want, or any icon from one of the many other free sets they have.
Thanks for sharing. I've heard great things about Eugene but didn't know it had much of a startup scene.
Secret White House Tweeter Loses Anonymity, and Job
Its a positive thing that someone publishing a crowdfunding project has a personal stake in it. If they spend money great, if they have a working prototype or have an existing business even better.
But the software doesn't exist in a vacuum. Older versions of calendar software stop working because Google or Apple change and the software is no longer updated, for example.
You basically have polymixins (colistin) and, depending on resistance profile, fosfomycin and tigecycline. Colistin is avoided if possible because of nephrotoxicity, but as usual, medicine is a field heavily involved in balancing risks and benefits.
The interviewed expert has very good credentials and clinical experience to be talking about what he is talking about, and his warnings should be taken seriously. But even at that, the fallacious teleological language he uses about biological evolution by natural selection suggests a way out of this problem. When he says, "Bacteria, like any living organism, want to survive," and "So anything that we do to try and kill bacteria, or anything the environment does to try and kill bacteria, bacteria will eventually discover ways or find ways around those" he is making factual statements that are plainly incorrect on their face. Bacteria don't desire anything, and they don't seek out anything or plan anything. Moreover, it is perfectly possible for lineages of bacteria to go completely extinct, and that has undoubtedly happened more times than human beings are aware.

Current antiobiotics are themselves mostly derived from "natural" chemicals emitted by microorganisms so that those microorganisms survive natural selection to go on reproducing in a world full of bacteria. Many of the early antiobiotics, for example penicillin, are derived from mycotoxins produced by fungi. Human medicine can use chemicals from fungi for protection against bacteria because human beings and all animals are more closely related to fungi than either fungi or animals are related to bacteria,[1] so fungi have a biochemical similarity to animals that makes it likely (although not certain) that a mycotoxin that is lethal to bacteria will be relatively harmless to human beings.

And this is the way forward to developing new antibiotics. As we reach a deeper biochemical understanding of the basis of all life, we will eventually understand the differences, which are biochemical differences at bottom, between human beings and bacteria, between human beings and protists, between human beings and fungi (yes, there are some systematic differences between animals and fungi) and between human beings and all other harmful microorganisms. Only human beings have science labs and clinical research studies to come up with new defenses against the thoughtless, largely immobile threats from other living things. We can form hypotheses, test those hypotheses rigorously, and perhaps make some lineages of harmful microorganisms as extinct in the wild as the smallpox virus and rinderpest virus now are. The intelligence that the hominid lineage has evolved gives human beings advantages that bacteria will never possess.

[1] http://ucjeps.berkeley.edu/DeepGreen/NYTimes.html

http://www.nytimes.com/1993/04/16/us/animals-and-fungi-evolu...
> It's actually fairly common throughout the western world that the loser of a civil suite must supply legal fees.

It is uncommon in the United States. Which is why it's surprising.

In the last 200 years, American common law has diverged a great deal from British/Commonwealth common law, both in the law itself, and in how it's practiced.
I moved to Berlin from London just about 18 months ago. The startup scene here is very good, it's a whole different feeling in terms of the spirit and the people.

Come visit us if you're in town, we often have people in to say hello :)

https://www.somewhere.com/suttree
We can't discipline ourselves because there are giant vested interests in selling antibiotics and none in resisting buying them.
A Startup's Rosetta Stone: How to Succinctly Communicate a Business's Workings
This has already happened and Google has sold millions on it, and the buyers don't even know it.

http://arstechnica.com/gadgets/2013/09/balky-carriers-and-sl...
I still have spare time
Try http://icomoon.io/

You can upload your own (or others) fonts too.
Use only the ones you need instead of adding the whole font to your project.
Not just start-ups; larger companies, too. The process may dictate testing, but if, for example, there's an urgent production bug or some enhancement that "needs" to be pushed quickly, testing often falls by the wayside.
Didn't Evernote and Moleskine team up to do exactly this? How does Draft compare to the E&M offering? How does Draft expect to compete with E&M?
Snap – A JavaScript SVG Library
My issue on this one, and I emailed them a question about it on KS, is the privacy issues I see here. Before I'm going to trust sending a notebook full of private thoughts or business related content to an unknown company I need a pretty ironclad guarantee that the content is going to be handled appropriately. I love the thought of being able to refer back to my content digitally over time, but I don't dig the thought of some stranger getting their hands on my personal thoughts and being able to blackmail me with it down the road.

They said that their scanning partner is built with security/privacy in mind, but I need details before I'd just stick a private notebook in an envelope and mail it to some strangers, never to be seen again.
Kind of brandjacking - but as it is free product I fail to see this as an ill behavior.
Then why is ST3 still labeled beta?
Canlı Tv izle
Yüksek kalite yeni nesil canlı yayın tv izle..
Using Android to treat blindness in Kenya
How are we going to use fewer antibiotics when they are a profit making venture?
People use antibiotics to treat things that are not helped by antibiotics.

Antibiotics were routinely used for ear infection even though there's no evidence of benefit. Antibiotics were routinely used for viral illness where there's no possibility of benefit, and possibility of harm.

(http://www.cdc.gov/std/Gonorrhea/STDFact-gonorrhea.htm)

> Untreated gonorrhea can cause serious and permanent health problems in both women and men.

That seems like a reasonable use of an antibiotic. But maybe we should have been working out how to get people to use condoms.
The funny bit is that they don't really know what they are bashing :). What kind of open-minded approach is that?
My workmate wrote this service: http://marsjobs.net/jobs

Also, we're hiring Ruby developers (actually more Ruby than Rails in the future) right now: http://sponsorpay.com/careers
Ha! Great point.

One perspective might be that you'll get more bang out of your Kickstarter if you show the backers that you've done some work first. I'm more likely to contribute when I see prototypes than vague ideas.
A good illustration. Your phrasing "The bacteria has developed resistance to the antibiotic" is of course better understood as "the descendant bacterial cells have been ruthlessly selected for resistance to this antibiotic." But that is not an invariant characteristic of bacteria. It is perfectly possible to completely wipe out a population of bacteria in a particular place so that the bacteria have NO descendants.
The difficulty is avoiding treatment and not diagnostics. If your method of avoiding treatment is never going to the doctor, ie, never being diagnosed, you don't really know when your problems are life-threatening.
I honestly don’t get the fuss about multi-monitor support. Mavericks doesn’t add multi-monitor support, it’s always been there. What Mavericks does is fix multi-monitor behavior for fullscreen applications, which I personally would never use on a display larger than 13" anyway, non-fullscreen behavior hardly changed, so I really don’t understand the big deal.
That's an interesting way to look at trust but it's highly dependent on your own internal thought process and phrasing.

"I trust he WON'T let go of the ladder."

That's the same as

"I trust he WILL keep the ladder secured."

I'd say trust isn't about what you think the person won't do. It's about the person living up to their word or implied contract. It can be phrased either as a will do or a won't do.

Ladder guy holding it implies he will hold it securely. Doctor with private info implies he WON'T share it irresponsibly. That could also be worded as an expectation that he WILL keep it private.

"I trust Bruce Schneier to not sacrifice his own principles and belief system in backdooring some code or otherwise compromising his work."

OR

"I trust Bruce Schneier to be true to his principles and belief systems and maintain the integrity of his work."
Embedded C developers can produce very, ehum, 'interesting' code. They usually come from electronics engineering and think in terms of registers and memory instead of an abstract machine. I've seen code that actually relies on two arrays being defined in order and thus can be indexed from only the first array but with a calculated offset. This is outside of a struct...

Just type casting a struct to a char-pointer and dumping it straight out on the network or to persistent storage is code you see every day.
Slide #4 says: "Suppose you are about to interview a candidate for a position as a C programmer for various embedded platforms..."
I've always been under the impression that bacteria pay a heavy evolutionary tax for their resistance. So what would happen if you then took a sample from the 1000x section of jelly and then another sample of your initial bacteria and put them on opposite sides of nutrient jelly slab. Would the new bacteria be completely overwhelmed?

Would infecting someone with a non resistant strain, letting it sit for a while and then hitting them with antibiotics knock the infection low enough that your immune system could wipe up the rest?
Daily5: Unapologetically Simple Task Management List
With connectivity about 600x better than the average rural broadband connection. The direct application to purely to solve a problem it is great to see what we can do. That said it is kind of a bummer to see that once commerce gets involved that 1.5 dsl is good enough to claim your check from the FCC...but leaves a lot to be desired when trying to interact with the Modern world.