skysight-inc/HackerNews huggingface dataset:
> "Vyvanse is just a more concentrated version of the d-enantiomer"

Not at all; it's a prodrug that is converted into the d-enantiomer by your liver, at whatever your xenobiotic-metabolic speed is.

The major result of this has nothing to do with how safe a regular pill-dose of Vyvanse is vs. Adderall (or, equivalently, Strattera vs. Ritalin.) Instead, the effect is that you can't convert Vyvanse into an injectable or smokable form to make it absorb faster. There's no simple physical process you can put prodrugs through to turn them into something that will get you high; they need the full biological environment of your liver to be "unlocked", and it will only do so at a rate safe for you. (Or it'll create cytotoxins if you overload it, but this still won't get you high.)

And because of this, it's much safer statistically to prescribe it; with Adderall/Ritalin, there is a high chance that any voluntary self-diagnosed case will turn out to be a junkie/drug-seeker/drug-seller. With Vyvanse/Strattera, that potential for "malicious use" doesn't exist[1]. There are still all the same medical dangers, to be judged by doctors on an individual basis -- but there's a far lower worst-case downside in prescription.

(Further, prodrugs aren't addictive when taken at recommended dosages, since addiction is [likely] caused by your brain correlating spikes in its chemistry with recent memories, and prodrugs aren't "spiky" in the way their raw agonist or reuptake-inhibitor forms are.)

---

[1] Well, it does, but only in the nootropic/"study drug" market; not on the street.
Just hit this error myself -- found an easier way than restoring from backup.

First, download the latest iOS7 version (I used an ipsw from this website: http://www.iphonehacks.com/2013/09/update-ios-7-beta-ios-7-p...)

Open up iTunes and go to your iPhone, and press alt/option + the "Check for Update" button.

This will open up a window that will allow you to browse to your ipsw download. Choose the iOS7 ipsw you downloaded for your phone, and choose it. After 20 minutes, your iPhone will update, and you'll be ready to go -- no restore required.
Oh, I see. Yeah, I wasn't suggesting that this in particular should drive them out of business. I was wondering how the kind of person who thought "flying to India to research a product for India" was trimmable fat would be able to successfully keep a company afloat.
Did anyone find this extremely rude. I was suddenly locked out of my own hardware for which I paid hundreds of dollars. I stopped receiving calls in the middle of the day.
Why do they have to treat people who installed beta like they are criminals on a parole. Where is the magic Apple ?
26 Years to Release Snowden Docs by The Guardian
Server Status Live Demo
I have Find My Phone turned on. Can I just upgrade / restore the iPhone?
Can't they just gain access to the account and call it a day? No need to transfer the funds elsewhere, really...
ADHD is defiantly a real thing, but I don't think we should drug it out of them. We should make sure they go into suitable jobs/schools, where adhd would have advantages as opposed to disadvantages.
If you do happen to corrupt any SQLite database file, it can usually be repaired... unless it is on an Android phone and the app tries to re-open it before you can make a copy:

Android automatically deletes corrupt SQLite files!

http://stackoverflow.com/questions/7764943
The amount of oil used is tiny - less than a tablespoon for like 8 servings, plus almost all the oil stays in the pot.

You just need enough for heat transfer from the metal pot to the kernels. You can add more for flavor if you like, but you don't have to - the thinnest coating of the bottom of the pot is enough.
And Microsoft Research has a big facility near Google in Mtn View, and NetApp in Sunnyvale, a bunch of more mundane companies (Grumman, Lockheed, and Etc). I do need to get out and hike more though.
There’s the part about common sense and reading the release notes.

It is a beta software. Historically, iOS betas do expire.
Required starting in DFU mode + restore. Didn't think to try option + update as eggbrain mentioned above.
Does this mean Find My iPhone can be circumvented with a DFU mode restore?
I was able to update my 4S by downloading the official release and updating it in iTunes by option+clicking "Check for Update" and selecting the file.

If you have a 4S: http://thepiratebay.sx/torrent/8936924/iPhone_4S_iOS_7.0_(11...
> There's no simple physical process you can put prodrugs through to turn them into something that will get you high;

The fact that Vyvanse is a prodrug is emphasized heavily in its marketing, but the anti-abuse potential is overstated, IMHO. Even some very cursory searching on Bluelight, et. al. will yield a dozen ways to either magnify or dampen the effects of Vyvanse using common foods, etc.

> with Adderall/Ritalin, there is a high chance that any voluntary self-diagnosed case will turn out to be a junkie/drug-seeker/drug-seller.

Well, we can't prescribe any psychiatric medication, addictive or not, to people who are "self-diagnosed".
"SF isn't north enough to be Northern California" is a common view of people who live in Eureka, Redding, etc., but in my experience people who live in SF think of it as northern California. California basically has two big centers of population: SoCal is LA and friends, and NorCal is SF and friends. Above that are remote regions heard of in legends (either old legends about the gold rush, or newer legends about pot farming).

The Bay Area is definitely not within Central California, taken as a sociogeographic term. The Central California Coast is the coastal region between roughly Santa Barbara and Point Lobos, centered on SLO. There is also another inland definition of Central California: https://en.wikipedia.org/wiki/Central_California
A regular classroom is used to teach material, and home study is used by students to further explore and reinforce those concepts. A flipped classroom has students learn the material on their own (e.g. video lectures), and then class time is used to reinforce and explore the material.
B3 Bomber Jackets and Flight Jackets from American Mystique 
http://www.americanmistique.com the best place for B3 Bomber Jackets. We offer the best B3 Bomber Jackets online. We have the following jackets in stock B3 Bomber Jacket,The B3 Bomber Jacket in Long Sizes,General Officer's B3 Jacket,RAF Shearling Jacket,Cockpit Hooded B3 Bomber Jacket,B9 Bomber Jacket
You locked yourself out by deliberately installing a time limited piece of software and then neglecting to update it when a complete version was offered to you for free.

You aren't being treated like a criminal on parole. You're being treated like a software developer who understands how to handle pre-release software.
Late 20's and you're asking "am I too old"?
Read the continual developer release notes next time. When Apple released the GM, they had specific instructions about updating from the betas. If you are a developer engaging in the beta program, this is something you should have kept tabs on.

Having said that, yes, Apple should have handled this more smoothly. However, it was documented in the developer documentation.
It was early-mid 2012. It was in the middle of the mass exodus of customers from T-Mobile, and before they rolled out the new anti-contract strategy.

If you read the contract, even if you move to an area with zero phone or data coverage, you still have to pay an ETF. My case should have been excluded, because I clearly fell within the clause about military personnel, and I had on multiple occasions been told by their employees and management that everything was good to go.

To be fair, I worked as a telecommunications technician for a decade, and the entire industry is really shitty. None of the companies seem genuinely interested in providing value to their customers, and new plans often end up being more expensive for most people. When I dumped T-Mobile, I ended up using a pre-paid plan through Straight Talk. I get the same level of service at half the price, and I don't have to worry about getting fucked by a greedy, unethical corporation if I feel like cancelling my service.
Where is the Sunnyvale city centre?
The "flipped classroom" is an instructional technique where students watch a lecture or some other instructional resource on their own and then come to class to work on problems with the teacher. This is an alternative to the traditional classroom where the teacher lectures and then the students leave to do homework.
Novartis and Jannsen are on that list, and they make Ritalin and Concerta, respectively.
I believe that is my point. The timing and strength has nothing to do with it. I was the commander's gunner on a .50 caliber machine gun because I was a good shot. The barrel "travels" upwards. It isn't really about holding it down, it is just the physics.

Have you ever fired a fully automatic weapon?
Someone should write, for the starting-out 22-year-olds out there, a guide on how to do technology outside of the Bay Area.

The Bay Area had a great run, spanning several decades, but the VC darlings and private equity carpetbaggers who never belonged in the tech scene, in their zeal to turn everything into a shitty New York knock-off, ruined it.

It's not the land of opportunity any more. You're not going to get rich on 0.05% "equity" (inequity?) in some hail-Mary startup, nor are you even going to get the implicitly promised (but rarely delivered) investor contact and the mentoring to be a founder in the next go; get real, the train has left the station. I don't know where the next emerging opportunities are, but if you're 22 right now and have no inherited connections, the VC-funded nonsense is far along in its decline process that, by the time you'll be positioned to take advantage of it, the opportunities will all be gone.

Bay Area VC-funded companies are now the conservative, boring choice. They don't involve much risk. There's almost no upside, because engineers aren't respected in that world any more. It's what you do if you're 22, intelligent, prestige-focused, and can't think of anything else. There's nothing wrong with it, as such-- most 22-year-olds have no clue what the fuck they want to do with their lives, that's nearly universal, and it's generally not a mark against the person-- but it'd be better to see more material pointing the young to something that still has real opportunities. VC-istan social climbing ain't it. It's become like the investment banking analyst program, but instead of getting a bonus every year, you get a get a bonus at "liquidity" if that ever happens-- and if you're an engineer, it's a mediocre one and you'd have done better at a hedge fund.

If I were just coming out of school, I'd move to Chicago or Austin before San Francisco, just to avoid the effective debt bondage of exorbitant rents. New York's also nice if you're into finance, although its tech scene is pretty pathetic.

The real goal should be to end the tyranny of location, because it hurts people on both sides. First, it forces people to move out to San Francisco who really don't want to be there; that's probably half the Bay Area tech industry-- people go for the opportunities that are there, not the place itself. Second, it drives up rents and ruins things for the natives who've lived there forever and love the city-- and it should be given back for them.
A good collection of geek humor
How are they identifying the owners of these hidden services?

Are denial of service attacks the answer? DDOS a site and just ask popular hosting providers if they're experiencing any unusual traffic levels?

Seems like such an attack always precedes a takedown.
The myth of the brainstorming session
The next new thing online Business Marketing Power
http://www.businessmarketingpower.com Our home is in St. Paul, Minnesota, and from there, we offer an extensive variety of search engine optimization tools to help you and your site. We understand the necessity of internet presence for small businesses. Today's economy is rough, and we strive to make it easier on you- by providing our services at an easily affordable rate, and by helping you gain visitors to your page. More visitors to your page means more business! We specialize in helping out small businesses, including restaurants, real estate agents, photographers, and more. Whatever the need is, we're here to help. We offer free consultations, because your time and money is meaningful to us. Because of that, we also offer 24 Hour Customer Support- your concerns are our biggest concern. You won't have to worry about the quality of work that you're receiving: we guarantee that you'll be completely satisfied. Why? Because it matters to us. Our job consists of helping you with your online presence, and we won't stop until you're completely satisfied.

I encourage you to visit our website at
I too was 'told' I was up-to-date, and lost a ton of parade pictures of the family from this morning. Badly done, Apple. Badly done.
Kettle cooked tastes totally different, crisper, less grainy, thicker, and less oily.

And you can get low fat kettle cooked which tastes identical to me.
Why did I leave IBM Research? (2006)
They say,

"A Web where you cannot cut and paste text; where your browser can't "Save As..." an image; where the "allowed" uses of saved files are monitored beyond the browser; where JavaScript is sealed away in opaque tombs; and maybe even where we can no longer effectively "View Source" on some sites, is a very different Web from the one we have today. It's a Web where user agents—browsers—must navigate a nest of enforced duties every time they visit a page. It's a place where the next Tim Berners-Lee or Mozilla, if they were building a new browser from scratch, couldn't just look up the details of all the "Web" technologies. They'd have to negotiate and sign compliance agreements with a raft of DRM providers just to be fully standards-compliant and interoperable."

Well, so essentially like the situation with native apps then. My guess is most consumers wouldn't notice at this point.
Shutdown Simulacrum
Who are these nontechnical users who see Google as a ad company? I would think people who don't know about chrome would first think of google search, gmail, maps, google apps, google news, Android, Glass, and so forth.

WebKit powers the highest percentage of browsers, more than any other rendering engine. Not saying these stats are authoritative, but they are typical and similar to my own sites: http://www.w3counter.com/globalstats.php
Did you read the contract? Few do, but the contract you sign is the only evidence that you have of the deal. A person in a store or at the end of the phone can't change the contract, so buyer beware.
Appreciate the feedback - I still may try it, but that's not going to cut it for me. I'd still love to see it working though, so next question I ask I'll hook it up
Failure is losing the will to fight
Note that after some successful lawsuits by both employees and consumers Diacetyl is being phased out.
That's fast, nice! I wonder if you could "anonymize" the phone, which looks too much like an Apple device for my taste. I think Mozilla has always shown the right direction for net neutrality, and trademark neturality is also important in my mind.
That's lucky. It didn't use to work.
Before the iTunes Betas would expire and the beta iOS versions would only sync with those. Also they wouldn't allow updates to the final GM.
The CEO is modelling behaviour for everyone else at the company. He should not have to do this for every customer as by now the word should be spreading internally that if the CEO can do it, then so can you/
You knew you were running iOS 7 beta and you failed to follow up with the developer beta program.
You can always choose an MVNO if you want to. They run on same network as the big 4, although they might lack some roaming options. (and access to LTE, if that is important to you)
It can always give a gentle warning before locking people out.
Locked out of your iPhone today?
> Well, we can't prescribe any psychiatric medication, addictive or not, to people who are "self-diagnosed".

I meant "self-diagnosed" as in "books an appointment with a therapist because they think they have X, whereupon the therapist tests them for X, and then sends them to a psychiatrist who tests them more carefully for X and, finding that they do have X, prescribes them medication for X."

Junkies can and do game this by looking up the tests online (which are, if you didn't know, just battery self-assessments of correlated behaviors.) But the only way to prevent this (besides coming up with objective measures for ADHD involving fMRI scans, like they've done for depression) would be to only prescribe neuroaffective medications to people whose lives take such a bad turn that they end up talking to a psychiatrist involuntarily (i.e. in a mental ward), thus preventing anyone who is self-aware-enough to notice that they have a problem from solving it.
ADHD is not just a problem for children.
FBI was hoping you'd never ask!
You didn't have to lose those photos. You can "update" to a particular IPSW in iTunes [1].

So just download a "production" iOS 7 IPSW and "update" to it.

That's what I did to update when the iOS 7 GM came out, and I've used it in the past when I unintentionally let an iOS 6 beta expire.

[1] http://www.jailbreaksquad.com/wp-content/uploads/2013/01/Bro...
Nothing at all. Methamphetamine, which is not very different than the dextroamphetamine in Adderal, has proven to be a remarkably safe substance and in general, society benefits a great deal when people ingest methamphetamine. I'm sure schoolchildren being prescribed dextroamphetamine to take every single day for years is a very good idea as well.
You've been Tim Cooked!
Vyvanse is a prodrug of dextroamphetamine, which means that it turns into that in the body. The advantage allegedly is that it's less prone to abuse but the real reason it exists is that dextroamphetamine entered the market in 1937 and so its patent has long since run out. Dextroamphetamine in turn is just amphetamine with the left-handed isomer removed. This left-handed isomer is less potent than the right, but both promote higher concentrations in the brain of the same chemicals norepinephrine and dopamine.

Amphetamine you may know better under its colloquial name -- speed. That's right, Shire Pharmaceticals is upset that European doctors and parents aren't rushing to give children fancy, expensive, speed.
How to sink an Aircraft Carrier
Wouldn't another solution to this be to have an object that would mimic the dom, performing reads immediately (or reading from its own cache of written attributes), but allowing explicit control over when writes get committed? It would then be easy to have atomic (wrt dom layout) functions.
And then the owner can just have someone else transfer them to a different address. Suddenly they aren't seized any more. ;)
Adobe source code breach: it’s bad
Adobe source code breach; it’s bad, real bad."We also believe the attackers removed from our systems certain information relating to 2.9 million Adobe customers, including customer names, encrypted credit or debit card numbers, expiration dates, and other information relating to customer orders. "
It is in the release notes.
It would be difficult to be sure that there is only one person with the key. If the defendant has a co-collaborator who also has access to the keys and is outside the reach of the seizing authority (or unknown to them), they could just transfer the Bitcoins to another new address and out of seizure.

The seizing authority in general has no way to tell in advance if such a co-collaborator exists, and assuming the transfer is to a new address with no historical transactions, it would be extremely difficult to identify who the collaborator was after the fact.
I own the current MacBook Air and I don't care about retina. Yes, it would be nice, but I prefer the extra battery life. It's the best computer I've ever used.
Typically the 5th amendment argument applies to handing over passwords that are only in your head, not keys that are written down. The government can force you to turn over data you have.

The case for not turning over passwords for bitcoin wallets is probably stronger than for true crypt volumes.

If they arrest you with an encrypted volume on your laptop, they know its your's. The only question is what it is. In a lot of cases, the government knows what it is, they just need to be able to prove it. Courts call this a forgone conclusion and can compel you do use your decryption password( but not tell it to the cops).[0]

On the other hand, handing over bitcoin keys maybe the only way they can learn which bitcoins are yours. This is,arguably, not a forgone conclusion at all. And again, you are not just giving them access to the data, you are effectively being compelled to testify that it is your data.

[0]http://www.slate.com/articles/technology/future_tense/2012/0...
I was just in the apple store and heard someone complain about this. She was there for some other reason and it just so happened to strike her phone while she was waiting. The guy helping her was pretty puzzled and kept insisting she must have reset her phone.
And of course with the impending release of OS X Mavericks - which is highly focused on optimizing power consumption - we will get even more battery life out of our MacBooks. Based on preliminary beta reports the 2013 13" MBA will get closer to 14 hours in real world usage.
I own a retina and the battery life is simply horrendous.
Show HN: FreeWare Index
Thank You Steve
Were you suggesting that we should all have access to substances etc regardless of the laws in our land? I apologize if I read you wrong.
The thing I'm dying for is the trifecta:

- 1080p+ resolution

- 8 hour battery life (of actual use, say listening to music, web browsing and typing)

- Excellent keyboard

Pretty much nothing else matters to me.
That's pretty much just the Retina MacBook right there.
My rule of thumb: If it’s a CNET article, don’t bother reading it.
https is useless for package management, given that most people are downloading from mirrors. What you want is a signature over the entire repository, like Debian and Ubuntu do (not just signing individual packages, like Fedora does). Once you have that, you don't need HTTPS.
I want 24 hours of battery life in a small form factor. Everything else can be mediocre.
And note that the MB Pro 13" is only 20% heavier than the Air 13". A reasonable trade-off, if you care more about the display resolution than you do about the last ounce of weight and last hour of battery life.
According to blockchain.info [0] and Arstechnica [1], the seized SR bitcoins may be in address	1F1tAaz5x1HUXrCNLbtMDqcw6o5GNn4xqX .

[0] https://blockchain.info/address/1F1tAaz5x1HUXrCNLbtMDqcw6o5GNn4xqX
[1] http://arstechnica.com/tech-policy/2013/10/internet-lobs-insults-at-fbis-silk-road-bitcoin-wallet/
The main reason I like HN is because of this: one of the first few comments, in pretty much any discussion, points out that the title is sensationalized (and gives a more levelheaded discussion)
It's not Apple's fault that you didn't understand what you were doing when you installed beta software onto a device with content of sentimental value.
If they have a near global view of the network, they can do traffic correlation without having to 'ask' hosting providers - and putting a large signal through would certainly help that traffic correlation to occur.

It is possible that DDOS attacks are not actively initiated by the NSA, but that they greatly help them complete their traffic correlation analysis network to an acceptable level of certainty by lighting up the circuits from the rendezvous points to the hidden service.
I see ingenuity in the creation of the technique, but if it was handed down over generations without the understanding of why it works, then that isn't a display of ingenuity. Contrast that to a typical student in who is given the same task of multiplying 7 x 34. They can get the same result and are also taught why multiplication works.