skysight-inc/HackerNews huggingface dataset:
> To put it much more simply, there is nothing that a 6-year-old would consider “invented” about the patentable cDNA.

That's the point. Patent law is very suitable for processes that cost millions to develop, but in pharmaceutics the big cost factor isn't process development, it is the discovery. What Myriad did is identify the gene, that is where the cost was sunk that they somehow have to recover.

But since you can patent only things, and not intellectual property, the Supreme Court had to resort to all kinds of legal hacks of the sort that judges hate to see applied in their courtroom.
> I compared the Linode and AWS terms of service and neither has anything like this.

"No Illegal, Harmful, or Offensive Use or Content" is literally the first point in the AWS ToS and is all about what is "offensive" http://aws.amazon.com/aup/

> You may not use, or encourage, promote, facilitate or instruct others to use, the Services or AWS Site for any illegal, harmful or offensive use, or to transmit, store, display, distribute or otherwise make available content that is illegal, harmful, or offensive.
> Here’s the deal: if I tell you that SHA1(foo) is X, then it turns out, in a lot of cases, to be quite easy for you to determine what SHA1(foo || bar) is. You don’t need to know what foo is. It’s just that, because SHA1 is iterative and works block by block, if you know the hash of foo, then you can extend the computation to determine the hash of foo || bar.

This is simply wrong. Padding of cryptographic hash functions protect against this behavior.
Most large corporations, but for the freelancers and folks working for small business, a .torrent would be a godsend as an option. Especially if done with something like S3's torrent support, which lets Amazon function as the always-there seeder.
>the only people still around are old people, families, and marketers...and the weird kid from high school //

Which one are you? ;0)
That hinges on the definition of non-natural. Is a nuclear reactor non-natural? Are you sure? http://en.wikipedia.org/wiki/Natural_nuclear_fission_reactor

Just because you're using components that exist in nature that may come together and occasionally produce the result you want - when a human hand enters the picture to do it deliberately and get a controlled result, to gain a certain end, that's qualifies it as non-natural.
The operative word here is "could" as in "maybe" or "possibly" or "nobody knows if".

They didn't stop Boston. That is a fact.
Of the free GUI tools, BOUML (the old, open v4.21 in Fedora 18) had the best combination of available UML components and editing flow. BOUML was restricted/automated enough to give me the impression that I was describing relations more I was drawing them.

However, at the end of the rainbow I found PlantUML. PlantUML renders nice graphs using a GraphViz/Dot-like language and affords all the benefits of being plain text - revisions are intelligible, syntax is highlightable, and edits flow at the speed of Vim.

http://plantuml.sourceforge.net/
I imagine we will see $29.99 (or even less.. I would say even some as far as free if they were digitally distributed) release day games, but that the proportion of the game that will be included will be significantly reduced.. like you get the demo for free and $5 per level thereafter for example. All sorts of possibilities for pricing and making money in new ways for consoles.

I agree the use of discs seems a silly move, especially WRT new pricing models and the implications. IMO they should be optional; 50GB (?) is an infeasibly large download for a lot of places in the world today, but this is not the case everywhere nor forever. Digital distribution allows for more possibilities.

The problem with the reduced cost argument is that I really can't see cross platform developers pricing the Xbox version lower, so long as they believe it to be the equal to the PS4 version (which might not be the case, the PS4 seems it should have a little more graphics power). And as a consequence I can't see Xbox exclusives selling for less than those-- they won't want to appear inferior.

Add into that the fact that the PS4 will be cheaper too- I think who 'wins' in the upcoming generation may depend on how magic MS can make the kinect sensor-related software with media/TV control. If they can make it awesome and polished enough to make people forget about the fact they are putting an always connected '3d' camera into your home with an always-on internet connection in a device from one of the companies which has most-cooperated with the NSA (I wonder if they might justify the depth camera data as 'metadata'?), then I think MS could be on to a winner. If not, it seems advantage Sony so far.
Thanks for working to ruin a great thing for the rest of us.
Exactly. "“He told us nothing we didn’t know before,” Putin said of Snowden" that reads like he is trying to make life pricklier for the people claiming that great damage was done to national security by revealing these secrets. That is exactly the sort of thing I would say if I wanted to amuse myself by annoying US politicians.
This petition is probably just a confirmation of the majority of the names on that list

It's far worse than "just confirmation." If the NSA is training a machine learning algorithm to identify subversives based on various features/activities of those people, they need a set of labeled (i.e. subversive = yes/no) training data for the algorithm to learn from. They now have 100,000 extra training samples to help the machine learning algorithm better tune its ability to identify subversives. So, not only have the 100,000 people moved from the "probably subversive" to "known subversive" column, but the NSA is better able to predict subversiveness for all of the people that didn't sign the petition by comparing their features/activities to those that did.
Saying that Myriad was the first to discover BRCA1 is somewhat disingenuous; other labs did it independently at roughly the same time. Moreover, deciding when a gene was "discovered" is a minefield. What constitues discovery? Identification of a mutant? Cloning the gene? Sequencing it? There are many steps to this process.
yep I agree. The premise is that one has to totally unable to create a template with your favorite Office tool. Heck you could do that in Excel and that's already an insult.

This is completely useless without a system behind.
So that's an excuse for bad writing?
I use the hosted version of websequencediagrams.com for sequence diagrams and that works out very well. I know that sequence diagrams are a very small part of UML but I find that they have an extraordinary effect on clarifying a system's design without too much effort.
You should check out Tent. It's a very promising protocol for social networking. Their docs are at http://tent.io and you can see an example implementation at http://tent.is.
According to Greenwald, The Guardian is "not remotely" walking back any initial claims.

https://twitter.com/ggreenwald/status/345315199257047040

onekade: Confused about this. The Guardian "correction" doesn't walk back its initial claim at all. mediaite.com/online/fulsome…

ggreenwald: @onekade Not remotely - they're desperate to discredit all the spying, but it's not going to work. Documents are too powerful
I dunno if price is really the issue. People pay much more for downloads of desktop software and at equal prices with the physical counterparts. You rarely see anyone arguing that they should be able to resell Photoshop or Word.
Hodor from Game Of Thrones Is A DJ & Producer
"Direct access" at this point seems to be a semantic red herring. Until further details of the program are declassified, or, more likely, leaked, we won't know for sure.

I'm willing to bet that the truth lies somewhere in between all of this, and that Snowden and Page can both be standing near the truth, leaving the administration and NSA out in the cold.
https://saucelabs.com/
If they can decrypt some SSL (maybe low bit) it is likely a very intense process that requires vast hardware resources, so even if they can do it, it is not likely it is being done for all traffic, but could be applied to some traffic.
In America, what you call "non-joined up handwriting" we call "handwriting". I don't know anyone (anecdotally) that uses cursive on a daily basis except for signing checks and contracts.
>It has absolutely zero technical superiority over everything else out right now.

Not necessarily in the enterprise market. Based off my experience, their enterprise softwares are vastly superior other alternatives.

May I also mention the advancements of Kinect? The ability to scan and display with a great deal of accuracy: your body skeleton, your heart rate, muscle maps, etc is pretty awesome. I find whatever comes out of Microsoft Research to be very exciting. However the truth is most are killed even before they make it to the market (remember Microsoft Courier?), thanks to their internal politics.
It is true that textbooks are extremely over-priced in US because they are priced with multiple re-sale in mind. It maybe true for games but even so, it will take some time before the effect kicks in.

Part of the problem is that if something is physical, people expects it to be lend-able. E.g. Books, CDs, DVDs, etc. (you can also think of things you can borrow in the library) People don't expect their digital downloads to be lend-able (e.g. iTunes songs, Kindle books, etc.) In that sense, Microsoft has to play the game carefully. I think it will still work if games on XB1 sells at <$35 compared to $60 on PS4.

On the note of internet connection, as much as Microsoft thinks that everyone should have an internet connection at home today, it is still something that you should not expect everyone to have. Many XBOXes are sold globally and internet broadband connectivity may not come easily.

Besides the issue of lending of games, I do agree on the vision that the console will be a center piece of the living room. It is much more than just games.
I'm very interested to see if this pans out and how much exactly will this improve delivery times or the business in general. The writer says

"Called ORION, or On-Road Integrated Optimization and Navigation, UPS’ data-drenched route optimization tool aims to deliver the best answer yet to the traveling salesman problem,"

However, do not travel agencies/airlines already tackle this problem every day albeit perhaps a different facet of this? I wonder if there is dialogue between delivery communities and travel agencies and such, it would no doubt be beneficial. Maybe the people at ITA(now at google) and shipping people should talk/do commerce?

Seems like a healthy idea to me.
cDNA synthesis is very cheap, a few cents per base. They do like everyone else: charge whatever the market will bear, and, quite frankly, in healthcare this isn't something anyone should be comfortable with.
Much better design, but you're right with "[..] it makes me wonder if this space needs something..."

There is no benefit in this, except that it's in the browser, but that's all.
IE on Windows XP actually. IE follows the support lifecycle of the Windows version it is installed on since IE6 SP1, and IE 5.01 on Win2000 follows the support lifecycle of Win2000 too.
It's been around for a long time, but I really love the TTY mode of DDG: https://duckduckgo.com/tty/
Its a virtual machine though, just make a snapshot once you have it booted and working as you'd like, and roll it back when you're done. If I remember, that was Microsoft's recommendation as well.
Wow, a whole lot of product/business vision and dealmaking/tradeoffs, all of it quite sensible, and yet I see 4 pages of lecture and not a mention of fun, engaging games

Back to my NES...
I think I need to link to the relevant XKCD here:
http://xkcd.com/810/
And to slightly paraphrase: "But what will you do when Spammers provide useful and relevant content" "Mission Fucking Accomplished"

I'm not saying that's where we are -- But that's hopefully the end-goal
You're pulling too hard in the opposite direction though.

10-30% of that will come back in corporate or personal taxes, which will be spent again on behalf of US citizens, which will again be taxed again, etc.

If the advantage is 178:1, eventually there has to be a gain.
I think given the "direct access" note in the slide, SV's weird focus on the word "direct", the name "PRISM", and the outing of AT&T 641A a few years ago it is definitely within reason to assume they're beam splitting the fiber signal at the ISP level. That provides plausible deniability to Google, FB, etc.

What I want to know is how much of that signal are they (a) storing indefinitely, (b) DPI or SSL decrypting, and (c) merely keyword analyzing. If they're storing it indefinitely and/or utilizing SSL MITM then we're pretty much done as far as privacy is concerned. But if they're just keyword analyzing cleartext packets then honestly who gives a shit.

My gut is telling me they're decrypting SSL. FB and Google moved to HTTPS everywhere a few years ago and they're clearly getting this data somehow so...
You can also just snapshot them, and roll-back when you're done.
I wonder if any other intelligence agency is spying on the NSA, even if it is American. That would add such an interesting twist, and their justification and legal process for it would be no doubt rebuked by the NSA in a very hilarious fashion of not being able to take their own medicine.

I can only hope.
Somewhat related but I've been canceling my subscriptions (Office365 in my case) to services I can't properly secure..

I'm also in the process of selling my surface pro and going back to a Linux laptop (OneNote 2013 sucks with touch on the Desktop for me .. and Microsoft's Windows8 version won't allow you to not use Skydrive)

Also, I pay Microsoft .. why won't they let me save my OneNote docs in a secure way using their Windows8 apps?
Perhaps that's just a misdirection from the real redefinition:

#define metadata DNA samples for breeding a clone army
The militarized internet
Microsoft will stop supporting XP in roughly a year. Then you either upgrade or expose yourself.
Startpage/Ixquick is coming out with an e-mail service called StartMail: https://startmail.com.
Hmmm, that might explain why Pebble (the smart watch) support had this super passive aggressive sounding "if you keep emailing us about the same issue, we'll put your case to the bottom of the list" instructions.

Not the message you really want to be sending your already disgruntled customers - "Do I mail them and check to see if they even got my email which hasn't had any response in two weeks, or will that just put me _another_ two weeks further down their already abysmally slow response queue?".
Ooh, I would love this in screensaver form!
<rant>
>> Well, if you want the @#$@ing from Gamestop, go play PS4
Stop telling customers "take it or leave it". Tell them, "I'm sorry you can't do that", or "we've decided not to support X because Y". You keep telling us to go fuck off and buy a PS4, we might just do that.

Then you blame your half-assed approach on competitors (right after saying competition is good). You're Microsoft! King of anti-competitive practices. Why do you care what Target, Walmart, Gamestop, or Amazon think? If you wanted to build a Steam competitor, why didn't you build a Steam competitor? Why did you create a shitty Steam DRM system on top of physical media.

>> We want to own the living room.
Do consumers want you to? Every update to XBox 360 has made it worse.
- more ads on the landing page instead of instant access to recently used apps (e.g. hiding Netflix).
- the horrible decision to make subtitles the system default, then keep turning it back on (seems like every 2-3 weeks it forgets I don't like them)

Prediction: XB1 home screen will just be wall to wall ads with a tiny little "play game" thing in the corner 7 screens over. Every time I want to play a game, I will probably have to scroll by shitty music offerings, shitty game previews, shitty video offerings, etc.

>> You can turn it off tho, and turn the console like OFF off
I bet this will be obnoxious and tedious. Switch on the back? Inside a settings menu?

>> We basically made a huge cloud compute shit and made it free
Really?!? No more Live fee? Did I totally miss this? or by "free" do you mean for "for sale costing money on an ongoing basis for consumer, but free for publishers"?

>> If all you do is play games, and nothing else, PS4.
This is why we're pissed and you seem to have missed that. Xbox should be a game console first, and a media machine second. MS has said they've made a really awesome Tivo + Roku machine and it also plays games.

So yeah, that's why MS is getting flak. But the real issue is that no one at MS seems to understand that!
</rant>
In transit it’s actually pretty good bet it is encrypted. Now at rest it’s entirely different.
Followup.

Why is this tidbit such a big deal to you? I think you have unrealistic expectations.

Have you ever tried to get a story published in the "mainstream" media?

I've done technical writing. I also spent years explaining my pet issue to journalists, reports, policy makers, other lobbyists.

It's a miracle if the message gets thru mostly correctly.

You ever read a story about topic in which you're an expert? Then you know the press never get the story completely "right".

Even if lawyer Greenwald understood what computer expert Snowden was trying to explain, he'd still have a hard to time running that explanation past his editors. And I'm absolutely certain that whoever is reporting tried to explain novel ideas using layperson's language.
Technically, it is a court order, not a warrant. So it is warrantless.
You'd say that correlating certain mutations in the gene to increased risk of breast cancer constitutes discovery, it certainly does in the context of a clinical test for breast cancer, which is what Myriad is selling.
New game dev site - The Game Dev Academy
Chrome Frame was brilliant: users still click on the blue e, all of the horrible enterprise loathware apps continue to work but pages which opt-in are suddenly much better looking and faster.

Large organizations, particularly those which train non-IT workers to follow consistent workflows like to avoid any changes. Chrome Frame was great because it was a minimally disruptive opt-in for a better web; Chrome for Business requires you to switch to Chrome for everything and whitelist legacy apps/sites – that might happen if someone at the C level is really scared about security but it's way more risk and the shops in question are among the most risk averse.
Greenwald is known to publish without running his work past an editor first.
I think Kahneman has a name for this common fallacy in this book -- it's the one wherein small samples always appear to change radically because they are... uhm... small.
Do you also tend to feel ambivalent about political parties and religions?

These feelings largely depend on whether you view the world in absolute or relative terms.
Wow Microsoft is really keep their engineers real high on that Kool-Aid.

I'll believe this when I see Xbone games cheaper than $59.99. AKA I'll probably never believe this.

We'll see they may be progressing home entertainment forward but they're really taking a gamble by screwing over their core audience to do it.

For reference almost all of my console gaming is done via rentals and from what I see the Xbone doesn't support that at all so I'm definitely out.
What turns my crank is the nitpicking to obfuscate the policy issue.

If the people freaking about "direct access" think it's wrong, I'd very much like them to correct the record.

tptacek? Care to explain precisely how the NSA slurps up all the data?
That's fucking sick. Nice work man.
If the HN front page aspires to be no more technically correct than the mainstream media, I think pg should just close it down.
Your friend’s idea is stupid. Now what?
hmm, this one? https://github.com/edoceo/imperium

Do you have a demo or screenshot?
Online purchases would be great, now how about an ISP that sells me the bandwidth to do it at a reasonable price that isn't Comcast/Cox/Time Warner/At&t? There's a reason I buy physical media.
Clever new naming service. Reward your friends to name your startup.
Meet Amazon.com's first employee: Shel Kaphan
Yes, it looks like you're correct.
They could get a valid key pair from a CA and MITM the connection. It could be detected if the user knows what the public key should be and compares it with what they received, but that seems pretty unlikely.
Still selling physical discs is pretty important because broadband access in the US is still pretty dismal so if they went pure digital their market would be unnaturally limited by customer's ability to download games in reasonable times.
It states that states are exempted from the relevant privacy law.

"The trouble is that state public-health agencies received an exemption from the federal law, formally the Health Insurance Portability and Accountability Act, or HIPAA, enacted in 1996. "

However I can't find anywhere why or what was the thought or legal justification for this, in private companies HIPAA lingo usage is almost a buzzword and everyone is very careful and people down to pharmacy technicians down to software contractors who write software to handle health information are aware of it. Why the change?
It would have taken less effort just to try out both frameworks, and then you wouldn't need anyone else's "evidence".
Just like I don't think that the average car owner would require engineering skills, or an average eater would require farming skills.

I'm talking things on the scale of fixing a carburator or cooking a home-cooked meal.
I might bet my life on HTTPS depending on what my alternate choices are. I'm loathe to bet my life on anything, though.
It is not simply wrong. The usual Merkle-Damgard padding only means that you get something like SHA1(foo || garbage || bar) instead, garbage being smaller than the hash's block size.
I mean, MS helps governments spy with Skype, and now they want us all to have an always-on system in our living rooms with cameras and microphones?

I'm normally the one defending MS, but come on. Unless I have my facts wrong about Xbox 1, Xbox 1 is literally doo doo.
This is wrong and dangerous. From whom are you trying to keep these variables secret? Assuming a sane sysadmin, sensitive files would only be readable by the user which needs to run the application. And environment variables can be read from the procfs file system by the same user that launched them: http://serverfault.com/questions/66363/environment-variables...

Not to mention that if an attacker has shell access to your application user account, you're already owned. So again, who are you trying to hide these variables from? Because it seems like this is just security theater and additional inconvenience (why delete and recreate the file on each deploy?) for literally no benefit.
Other comments here say Chrome Frame is open source, minus the MSI itself (just a "very thin wrapper").
https://src.chromium.org/viewvc/chrome/trunk/src/chrome_fram...
A cruise line is not going to get "outmaneuvered by a startup using technology which less than 10 year old.

Nor an insurance company.

Nor a bank.

Nor large agrobusiness.

The tech industry is not the only industry that exists in the world. There are many industries where software does not form the basis of competitive advantage. In those cases, IT is not the most efficient use of capital.
FAT32 is common on portable storage (SD cards, USB 'thumb' drives), especially when cross-platform support is a concern.
Isn't OTR usually don client-side?
Leaker's Ties to China Probed