skysight-inc/HackerNews huggingface dataset:
That is absolutely false. We cannot reliably design drugs computationally, and that doesn't even take into account the tremendously difficult problem of predicting efficacy and toxicity. Drug interactions are very complex, poorly understood, and while our ability to do predictive analysis has improved a lot, we are not even close to designing drugs computationally today. What we can do is minimize the amount of trial and error and direct fugure experiments.
We've open-sourced/refactored a bit of our codebase which we used to develop our Thirst Droplet google glass app and released it on github!

It's a ruby gem intended to be used with rails for developing glass applications. We'd love to hear what everyone thinks! :)
Looks like Google partnered(?) with Braintree, Shopify and Freshbooks-- like you can get a discount for transitioning. Considering how many people mention just moving to Stripe on this thread, I wonder what sort of hoops those three had to jump through to get their names on the page. Also I wonder what part of the process led Google to choose those three over their competitors.

It seems like Stripe would have been a natural choice. Anyone know anything about the vetting process and want to comment? It would be interesting if there was a hangup or concern that led to the decision.
The redesign looks awesome, but who's going to pay a recurring $49 just to remove ads?

Can't help but think their money men might be about to screw this up. Hope not, love Flickr :-s
Bad week for an announcement, eh?
Good thing I'm not using Google Checkout anymore. It's still a shame though. I actually like it more than Paypal but having done some experiments with my ecommerce businesses (e.g. http://www.wellingtonstravel.com/) I found people trust the Paypal payment option more or are more familiar with it, leading to more conversions. So that's why I went with Paypal over Google Checkout.
Why is this the top response? That's exactly the point, there is nothing wrong with delicious snacks. The problem is that have a mountain of evolution distorting your "free market" of food choices, and snacks optimized for deliciousness flipping biological triggers that want to make you eat more of those snacks.

And yes, you can overpower those triggers, but we're talking about over a nation's population. Plenty of people care and still end up gaining 2-3 pounds per year, which is really not that much (20-30 calories over your expenditure per day, on average), but 3 pounds a year really adds up over a decade or two or three.

As for increases in the demand for healthier food, I urge you to read that article for how that demand is met, often in ways that are not substantially healthier (if at all).
4) It annoys the people who do use your product especially if they were already happy with it. Chances are they were the early adopters and evangelists. Their voices are what leads to #2 amplifying the actions.
The media needs to work on a whole solution for talking between each other and receiving information in a very secure way. It's clear the government is spying on many of them. We've just found out about AP, but who knows how many they are spying in the media. Probably all of them.

They need to start using stuff like Tor, DeadDrop, OTR-enabled apps, TextSecure, RedPhone, etc. These need to be part of the policy at the companies.
It's more useful but also too crowded. And it really doesn't make sense to a popup for someone who logins with Facebook. Please fix the login.
First they ignore you, then they laugh at you, then they fight you, then you win.

There are a lot of interesting aspects to electric-only cars, especially from a manufacturing aspect. There are lots of parts that you just don't need in an electric car, which can lead to efficiencies of mass production. Now that electric cars are no longer either improbably futuristic nor merely the butt of jokes a lot of people are finding it easier to have an electric car be a part of their lives, and that's a pretty big deal. I don't know how things will go, but it'll be nice to get a lot more R&D into electric vehicles for a while.
Exactly. Price differences for the very same product is not competition, its market inefficiency.
It definitely feels neglected. What do you think is a good alternative?
I don't know about iPhone, but they pushed an update to their android app simultaneously with the website launch. I don't do video, but the app added the "video" permission, so my guess is it will be back soon.
I'm not quite sure how I got to it, but go to user's stream and then tack on a ?details=1 to the end of the URL. I have no idea if that's an intentionally preserved view or not, but it's more like you're looking for.
To be honest, for the target audience of this book, CUDA is the only thing that matters right now. OpenCL and DirectCompute will possibly be significant in the future if AMD and Intel can catch up with NVIDIA in GPGPU performance.
So, who's already working on their "files stored steganographically in Flickr photos" cloud storage filesystem?

Or perhaps a little more practically, a WordPress/Joomla/Drupal/whatever plugin to use Flickr as a CDN?
I believe ReiserFS did that.
Weird. Mine got downvoted a couple times too.

It would be great if people would take the time to point out whatever it was that they found to be objectionable.
The Drive client on my Mac would constantly hang. I actually just uninstalled it.
This is a travesty of justice.
The media conspires to take attention off the electeds who execute the Koch/Soros/untouchable's strategies.
I wish I could just send email like that. Click an icon, a 350x250px box pops up, add address, subject, message and hit 'send'.
I find it interesting that so many successful startups originate from Sweden.. (Spotify, Skype, Tictail, Klarna, etc). Why don't we see similar success stories from e.g. eastern Europe or even France/Spain
7 more content conversion mistakes [Web Domination Podcast]
It is a necessary engineering fix. Any new design they introduce will have to go through extensive testing and verification that will take months. The goal here is to be able to assure the authorities and the public of absolute safety as quickly as possible.

You have multiple factories staying still at an enormous cost because of this. You have angry customers that have billions of dollars worth of planes standing still (while they have to pay interest on those billions of dollars). This is not the time to get creative.

If they were starting from scratch they certainly should have done something better and put it through the usual verification channels. But there is no time for this now.
I won't buy any books from them until they do DRM free epubs that I can download. (The same applies to all vendors.) They do get this right with their music.
I don't have any fingers, you insensitive clod!
To me at least, Twitter serves that role. The asymmetrical follow model makes sense.
And the big question as to whether a Tesla is a "trip" car or "commute/grocery grabber/fun" car.

There is a large market for electrics that don't meet all the needs an ICE can do - many many families have more than one car. Especially the ones that can afford a luxury vehicle like a Tesla/Audi.
Isn't this just a repost of this?

https://www.kennethnorton.com/essays/productmanager.html
The following list is even more fascinating http://en.wikipedia.org/wiki/List_of_acquisitions_by_AOL
Personally, I'd like Flickr to be both a photo viewer and organizer. I don't feel like the new interface is any worse for organizing photos, and I'm much more likely to point people to a flickr set with the new layout.

Your opinion seems very much in-line with the hugely negative reaction thread on flickr[1]. I'd be interested in the specific functionality you lost in the update that you miss.

[1]http://www.flickr.com/help/forum/en-us/72157633547442506
I think we are up for another fight on this topic very soon, but not only with Tesla. There are existing laws that force manufacturers to provide standardized maintenance interfaces, provide guidelines to shops etc., but increasingly cars are controlled by propietary computer systems.

And the whole thing takes a turn for the absurd when you consider electric cars. Sure, force manufacturers to provide documentation on how to replace a bumper.. but its purely naive to think you could have just any mechanic service a completely computer controlled high-voltage battery compartment.
Congratulations You Have Received a Meaningless Endorsement
You can! Minbox does that too... AND there's a global keyboard shortcut to compose a new message (CMD+Option+N).
The problem is the overwhelming majority of 17 year olds don't know enough to make useful pharma research. And other than research not much really scales well-enough to be worth 30 million.

Think of it this way computer research goes back around 100 years, medical research goes back well over 2,000 years. There is simply less low hanging fruit left.

PS: Consider this there is a large but finite number of reasonably stable chemicals with 10 atoms or less. All of them have been considered as to there medical impacts. (There toxicity if nothing else.)
In ordinary circumstances, yes this is all true. When the clusterfsck that was the Facebook IPO happens and the market shuts down for hours, no... there was time to cancel that order. If her order was sitting in a queue somewhere waiting to be executed, it should have been able to have been removed. If it wasn't, then Vanguard should have at least been able to tell her what its status was.
Another way to think about it is that if someone told me I would be paying $500 for a phone before the iPhone came out I probably would have laughed at them. In fact, before the iPhone I don't think anyone in my family ever bought a phone that was more expensive than the 1 cent models that came with contracts. Now we buy the $200 models that come with contracts.
This is an easy question to answer. Here is the UK Budget: http://www.guardian.co.uk/uk/datablog/interactive/2013/mar/2...

Please highlight the total sum of things you expect to do harm, and the total sum of things you expect to do good. It's my belief that it's a very small proportion.
Ask HN: Finding people with common interests made easier
Hello everyone,

I had an idea and I wanted to hear what you guys here think about it.

Here's how it works:
A user lists interests (hobby, school, city you live, etc.), then he/she leaves a message to people who have more than one overlapping interest.
Lets say he's interested in chess and Springfield. When he leaves a message using chess and Springfield, anybody who listed those two on their profile will see the message.

So you may think of it as a twitter hashtag, but you would get a push when there's a message written with both #chess AND #springfield.
You can also simply switch the combination of interests to reach out to a totally different crowd, like baseball and springfield.

Would you find it useful if there was a service like this?
Yeah... I am dead serious that I did not feel ripped off. Learning a lesson is worth every penny, in itself. Having someone else risk a spark near a gas source is a special kind of cost. :)
That line is on his blog as well :)
I would imagine the people that need more than 1TB would be professional photographers who use flickr as a portfolio / advertising.

If you are such a heaver user that you need more than 1TB of space, you are unlikely to want to split your account into two and your would probably be unlikely to balk at spending $500 per year on what would be for you a business service.
What is that huge "joined on" text? Am I blind? Do I want to see that? Is it something useful? Yahoo obviously needs to hire a designer. It looks like an intern designed it.
Skype was actually developed in Eastern Europe (Estonia).
Are you sure about that? Check the TOS. From everything I've seen online, everyone hates processing prepaid cards.
Go bold. Love it.
Did Bill Gates rip-off Tim Patterson ? Paying him $50,000 for MS-DOS. Jim Clark was able to buy a helicopter but he complained about this too.

http://www.pehub.com/45502/billionaire-jim-clark-vcs-take-to...

I think you are arguing for a more progressive tax so the top is paying their fair share.
Director/Manager of Web Engineering - PagerDuty San Francisco
Web Engineering Manager

Job Description

You're a seasoned engineering manager -- expertly adept at managing people and projects alike. You've heard the stories (and perhaps have first hand experience) of useless layers of management at the big software houses. But you also know that solid management can make an enormous difference in the day to day productivity of both individual engineers and engineering groups as a whole.

You've thought about working for a startup, but haven't yet found a small software company that understands that "no managers -- ever" is just as much of a mistake as bloating a company with useless layers of management. In short, you want to find a startup that values strong engineering management skills as something very distinct, but just as important as raw coding ability.

Responsibilities

We're looking for an engineering manager who will take charge of our Web Engineering group. You will be responsible for:
building a great team of engineers, and leading them to make sure they can do their best work
working with the other engineering groups, sales & marketing, and the founders to make sure that the efforts of your group remain aligned with the objectives of the company
debugging the engineering process when things don't go according to plan, and implementing fixes where necessary

Requirements

You've worked for 3+ years as a project manager. You've experimented with different software development methodologies, and have an opinion on what works and what doesn't. You know there is a careful balance between up front thinking and shipping stuff and seeing what happens.
You've had direct reports. You know how to hire and retain great engineers. You know how to deliver both praise and constructive criticism to your people. You've seen many kinds of "people problems", and know the importance of catching them early.

Although you might not code everyday, you are still familiar with your CS fundamentals and emerging technologies. You are not hesitant to fire up an editor and write some Rails or Javascript when inspiration hits.

You are genuinely excited by the prospect that 1 hour of carefully applied effort on your part can save 10+ hours of our engineers time. While you might not write much code yourself, you are delighted knowing that your work helps those who do write even more of it faster.

Interested? Apply with your resume and a brief cover letter to jobs@pagerduty.com Thank you!
Oh, thanks! I wondered about those dots (they do nothing in Opera).
Note that it's not "can't", but "don't find it worthwhile". I might pour my heart into a big acquisition while simply walking away at the first sign of hassle when trying to save $500 on a car.
Google will officially retire its Checkout service on November 20
> That's wrong if I can find a single counter example. The same isn't true of my position.

It's true my statement was brief, but I have made that position more clear. It's not that government is always good, but in the present UK and US situations, the state funds a number of support programs which are horrendously underfunded.

I don't think any reasonable person could justify cutting social benefits or healthcare coverage, and so my position outlines itself.

Good programs like these should be funded until poverty is eliminated. There's plenty of money around to do it and Apple having $55b instead of $50b in investments would change nothing for them, and everything for hundreds of thousands of poor people.
If a mathematician wants to cross a road
It seems to work for me. After-all, I am a JavaScript expert :)

Nice work. I like the simple design.
Even if they are inherently spam there should at least be some confirmation of this before marking an entire website as unsafe. Naturally they can do as they wish.
> All of this has me really questioning how and where I want to apply my skills for the remainder of my career.

It's entirely possible to create technology that works the other way, such as inventing the power-loom that replaced expensive hand-weavers with larger numbers of cheap migrant laborers, spawning the Luddite movement to smash the machines to protect "good jobs".

There are surely lots of modern equivalents that replace the expensive few with larger numbers of cheap workers, simultaneously creating value and spreading wealth out. It could be something like software usability, or a process that lets locals produce something easily that they used to have to go to a central supplier for.
There's noting inspired about "put the fire hazard in a fireproof box". I'm not sure it amounts to a kludge, either - it's a quick fix, and probably not the most elegant one possible, but there's a good chance it would have been deemed the most cost-effective solution even without the time pressure.
Ah, the oldest scientific trap. In actuality you must form a hypothesis, then construct an experiment designed to DISPROVE the hypothesis. For example, for how many months must I eat 4000 calories a day without altering exercise or gaining weight (just hypothetically) before I cause you to reconsider your hypothesis.
Could you elaborate in detail how you are tackling significant problems like obesity, diabetes etc.? I'm genuinely interested in your work.
Beautiful Examples of Content-Heavy Websites
Because people thought it was helpful. Perhaps you should apply to the content police academy.
I used to be a flickr pro user, and then I left over a year ago. I do like the storage and overall design change, but there are other reasons I'm not really interested in going back.

#1 being

Don’t use Flickr to sell.
If we find you engaging in commercial activity, we will warn you or delete your account. Some examples include selling products, services, or yourself through your photostream or in a group, using your account solely as a product catalog, or linking to commercial sites in your photostream. If you engage in commercial activity elsewhere on the internets or in the real world, you’re still welcome on Flickr—in fact, we’ve even set up some best practices especially for you.

http://www.flickr.com/guidelines.gne

...which definitely takes some steam out of the previous "pro" account.

I've been pursuing photography as a serious hobby for just over 7 years. I'm not expecting to make tons of money in on-line sales; I just hate displaying most of my things with those handcuffs on.

I used to upload all over the place and just crave the attention of the favorites and likes, etc. Now I am more selective of what photos I publish and where. I'm much more interested in a gallery type offering. Most of my casual photos that I would think about posting back to flickr are already on Facebook or G+ where my friends and family can see them.
Its a relevant story, but the conclusions may not be relevant to the Tumblr purchase. Why? Because the context that was written in has shifted. Yahoo is a different place with different management now. A significant amount of time has passed, so things might be different now.

The only question is: is Yahoo different enough to not screw this up? And that's not something that can be answered any time soon.

Given how they've treated things so far, it seems like they've learned some lessons from the (ahem) 'successes' of their prior acquisitions.
I guess it's time for Linus Torvalds to do some web programming. (joke) His report shows:

"Linus seems to speak only one programming language: C. Maybe it's about time to branch out a bit."
">Many theorists argue that thousands of hours of focused, deliberate practice is sufficient to achieve elite status."

Really?

I feel like any extended experience among a group of "practicers" would dispel this notion.
In a sane system, America's car dealers would be viewed as an illegal cartel that interrupts trade and would be abolished. Indeed, a trade-interrupting cartel is exactly what they had in mind as they pursued a legislative agenda for decades to make it nearly impossible to sell new cars in the US without going through their system.
I'm probably more of a social anarchist than anything, but I think labels are often unhelpful. The beauty of our current situation is that we can build it on top of America as it exists today. No need to label it-- just build it. :)
Yahoo Stock Highest Since May, 2008
"All this is to say that the promises execs make on acquisitions are meaningless."

Well yeah, all promises are meaningless. Were any of these promises in writing as part of the acquisition? I mean are they legally bound to comply? If not, why would you expect to have any control over operations and decisions, regardless of your title, after being acquired? It's not your company anymore...

Also there's no detailed information about the meeting itself to show us how you came to that conclusion however true it is. I'm guessing they wouldn't listen to your advice, but again why would you expect them to?
When you commit a crime it's not just actually doing the thing that's the hard part. It's also getting away with it. If you don't accomplish the getting away with it bit, well, then you've pretty much failed as a criminal right?

The main character in this story assisted in the getting away with it part of the crime. That's an accessory. And it's absolutely a crime to be an accessory, and I'm confused as to why anyone would have a problem with that.

We can't have a civilized society if people don't help the authorities catch the bad guys.
Could this mean that could expand the number of countries that were supported by checkout?

I really hope so, not being able to sell in the Play Store/Chrome Web Store is something we've been looking for a while.
Is this still working for anyone? I keep getting:

The requested URL was not found on the server.
It worked for a little bit, but now I keep getting 404s when I submit a name.

Also, for my handle it keeps saying that there's not enough information to generate a report card. I would be a neat motivator to see what I need to improve to get a report. :-)
Whatever you might think, moving from the top of the market down has always been their plan.

See http://www.teslamotors.com/fr_CH/blog/secret-tesla-motors-ma... from 2006 to prove it.
There's a reason you don't have downvote :)
Stupid headline, well, duh, it's overseas. They pay 7 Billion here.
Sure, but you still have to shed that kinetic energy, which is what I was getting at the end. It's no use gaining a huge amount of kinetic energy if it just means you're on hyperbolic trajectory past the body. You need to still shed all of that energy with (traditionally) rocket thrust or equivalent which is completely equivalent to accelerating by that amount.

I was also basing it off a standard Hohmann transfer because sling-shotting and all of that jazz was out of my reach without my notes :) I am sure you can get a lower delta-v transfer from more exotic paths than just a Hohmann transfer but it's been a few years since I've crunched those numbers!

Nevertheless, aerobraking is one option of shedding energy when approaching smaller-orbit bodies but I neglected it when doing this first-pass analysis. However I agree with you that approaching smaller orbits gives you benefits that approaching larger orbits does not, by way of using the Sun's gravitational well.
Quick tip: How to get the old flickr look back
Fortunately for Tesla, they have a good decade of playing the underdog card ahead of them. Ford and GM do $280 billion in sales combined.