skysight-inc/HackerNews huggingface dataset:
There's a very interesting rule of thumb that is used in the protein folding field. If 30% of the amino acids in two different proteins are identical, then you can be very certain that they will have identical (or nearly identical) 3D shapes. However, it is entirely possible that two proteins have no sequence in common, yet still fold to the same shape. A friend actually stumbled upon just such a case when I was still doing protein folding work, and it was amazing to look at the sequence of these two different proteins and see nothing in common, then flip to the 3D structure and see that they line up almost perfectly.

Proteins are immensely cool.
If you wouldn't mind I would love some feedback on this. I haven't made a sale yet and I am not sure why.

ANY feedback is appreciated!
I wanted to add a vote for Lucida Console, but stopped when it was asking me to login. Oh well! I like the letter shapes in some other fonts better, but Lucida Console is the only one with proper horizontal width IMHO, although it could be I've just been using it too long.
Security through obscurity. The hackers don't expect you to have a hashed password? So what? This is no different from salting.

Also, by adding a new function into your password hashing have you changed the cryptographic properties of the composed function? Have you formally proved that these new properties are as strong as the uncomposed properties? No? Then don't do it.

DON'T ROLL YOUR OWN CRYPTO, PEOPLE!

Composing functions counts as rolling your own, btw.
Some Beginner Tips For Better Software Development
Google had a nice one back in 2004 also: http://articles.businessinsider.com/2011-07-22/tech/30049105...

But probably wouldn't work so good today. The first one to find the solution would probably post it on twitter, then the recruiters could follow :)
From http://ycombinator.com/newsguidelines.html

What to Submit

On-Topic: Anything that good hackers would find interesting. That includes more than hacking and startups. If you had to reduce it to a sentence, the answer might be: anything that gratifies one's intellectual curiosity.
How Writing For Yourself Keeps You Writing
I couldn't help but read this as sarcasm. I laughed.
Burn it down and you have fertile ground!
One thing about font choices is that they will vary depending on several factors:

* The pixel density of your display

* Rendering method (ClearType, OSX anti-aliasing, etc.)

* The size of text you prefer

* How sharp your vision is

* And of course, personal taste.

As a reference point, I'm using Windows 8 on a moderately high-density display for a Windows laptop, at around 140 DPI. I'm old, with less than perfect vision, but it corrects well with my single-vision computer glasses.

My favorite font these days, as I mentioned elsewhere, is Georgia. I just find it so easy to read.

Other proportional fonts I've tried for coding and liked fairly well are Verdana, Cambria, Rockwell, and Source Sans Pro.

The best thing, of course, is to try a few and see what pleases your eyes.
Plants need nitrogen in much greater quantities (10-100x) than they need iron. For this fertilzer to not be used as an explosive it would have to contain much more iron than would ever be used by plants. Too much iron can be toxic to plants, make plants poisonous for humans to eat and cause other problems. Another issue is that most soil is not alkaline, it's acidic, especially if it has been used for agriculture. The sulfur in this "fertilizer" will further acidify the soil, making it more difficult for many plants to absorb nutrients through their roots (and in a vicious cycle, requiring more use of fertilizer). I'm sure the people involved had their hearts in the right place, but this development doesn't solve anything and by reducing crop yields could lead to many hungry people.
We've been running this exercise for the past year now. During that time we've had several excellent applicants, no recruiter spam, and no "web developers" who couldn't describe how a website might track a session. And no random applications other than people playing with it for fun.
It is really common for Go programmers (I've even seen members of the Go core team do it) to say 'thread' when they mean goroutine. It is important to recognize there is a difference, but calling someone out for saying 'thread' when they mean 'goroutine' is pedantic bullshit on the order of calling someone out for calling a class method in an OO language a function.
You're essentially enlarging a background image while moving it at the same time right? very cool!
I am getting Heroku error page if I click the button under movies after signing in.
Well, I thought the point was that even an S&P-500 fund will suck some money away from you through fees. I wonder at which point it makes most sense to dump the fund and do just SPDR ETFs instead.
And with RCS for almost 30 years.
I don't think I've ever heard an iPhone's ringtone. Everyone I know has their phones on silent and checks alerts later.
One aspect that people stubbornly ignore in discussions of this kind is that nobody, in particular no 401k investor, has all his or her money at the beginning of the 50 year or so investment period. People start with a small amount, then add to that over the years. So each year, the principal grows via compounding and via addition of a certain amount. I am not going to bloat this thread with more math; it's not hard to do it right, and the fact remains that by and large, Wall Street fees are outrageous. I just want to remind everybody that all performance considerations must take into account that a real-life investor's account is subject to deposits (and eventually, withdrawals as well). Ok, self-praise is no recommendation, but I think I have all this pretty much figured out: check out greaterthanzero.com .
Discontented people within your borders are a much bigger problem then discontented people outside your borders though.

Also, as a potential future immigrant (native English speaker, doing a PhD in the US, not very culturally distant from Americans except perhaps for a greater appreciation of Monty Python) I would feel extremely alienated if told I had to pay higher taxes for the rest of my life just because I was born elsewhere. The current immigration system may be frustrating at times, but at least I can hold onto the hope that if I become a citizen here, I will have the same rights as everyone else. (Except running for president, which isn't relevant to my planned career path anyway.)
Nintendo Preparing to Allow NFC Payments on Wii U in Japan
I liked this article the first time around. Seems like HN needs to do a bit better job recognizing future submissions of the same article --

https://news.ycombinator.com/item?id=5603352

Personally, I think a mix of topix makes sense on here. History, specifically, an unexpected time capsule being one of them.
Very similar to the Gritty NY photos also from a couple of days ago --

https://news.ycombinator.com/item?id=3900275
The problem is with 401(k)s is that most plans don't have that many options, and its common for all of them to be expensive (compared to what you can get elsewhere). And not putting your money in 401(k)s is even worse due to the extra taxes.
How do you actually code effectively with a proportional font?

Without a monospaced font, column cut, copy and paste operations are effectively eliminated (as nothing lines up vertically) and that is one of the programmer editing constructs I use the most.

I could not live without column editing.
If you click through the tweet and then the bitly link you end up at this article:
http://news.sciencemag.org/scienceinsider/2013/04/us-lawmake...

which basically describes bills to defund basic science research in favor of near-term applied research.
Yes, I have fibromyalgia too. I consider it a non-diagnosis (like chronic fatigue syndrome, which may or may not be the same thing, but which I (also?) have). It doesn't tell you causes it or how to get better, or what it really is. So.

On most days, I'm much better than I described above. What really helped me is the protocol in the book _From Fatigued to Fantastic_. If you haven't read it, haven't tried his approach to fixing sleep and other imbalances, I CANNOT ENCOURAGE YOU MORE to check it out. The trazodone alone changed my life. Plus the magnesium, the B vitamin supplements, (sometimes) the adrenal supplements, heavily supplementing electrolytes with electrolyte pills (that's my addition)… these took me from being non-functional, unable to discuss facts or details or make decisions, or go further than the sofa, to being able to go out, see people, do things (with limits).

This week I've started naturthroid to support my normal-testing thyroid. So far it seems to be working. I have hope that it will stop the "crashing."

Hope you feel better.
And so my lack of formal CS education is exposed! I guess I've got some reading to do on the train into work tomorrow to properly understand the distinction.
ETFs charge fees too - Vanguard's Admiral Total Stock Market Fund charges a 0.05% fee, which is going to be smaller or comparable than almost any ETF (their comparable ETF also has a 0.05% fee), and certainly far lower than the index funds available in most 401(k) plans
That's why ab initio protein structure prediction is such a sought-after tool in bioinformatics. You can have an incredibly high degree of nucleotide/amino acid substitution between two proteins with the same structure, function and evolutionary history, but current methods of detecting these relationships still largely rely on sequence comparison alone.
This... reminds me of a friend's anecdote where a guy brought in to interview, describing himself as an "expert" in C, didn't know what a pointer was.

The interviewer had to "save" the situation by blurting (regarding the sample code given to the applicant on paper), "oh, those stars, yeah they must be typos. Sorry about that! Let's move on to another question."
Great example - Google's billboard ads were the inspiration when I put this together.
You nailed it. He was early in the immigration process.

In odd bureaucracy, he DID get a doctor's special gas ration anyway. (He had a good institutional job in the Kaiser shipyards.)

Come to think of it, that's another reminder that in those days, medicine --> home visits.
Do prisoners even get Internet access?
Is there someone at Stremor I should specifically talk to? When I looked at your site recently, referred by a Forbes article, I got the impression your technology for summary had become a closed solution (available just to your products).

Or can I access it just through mashape perhaps?
The odds of winning the lottery are not "astronomical" in the sense people usually mean when speaking of hash collisions.
Three wordsL

L Ron Hubbard

As for Steve Jobs, people have always loved beautiful and desirable objects. As long as there have been objects to love. And designers were hipsters way before Jobs' return.
I agree that the idea is brilliant, but there is no way I am reactivating my Facebook account to use this. I am sure there are others in the same boat as me.

Could there not be an option to receive matches/invitations via email?
More powerful language (primitives, concision, macros), more performance (JVM fun-ness).

Some aspects of the JVM (slow-start) are icky but the tooling works around it (in-runtime auto-reload without restarting the JVM).

I'm a grumpy old CL'er so I was waiting for something like Clojure to come along anyway.
IMO they are far from indistinguishable (maybe you are thinking about Menlo?). I find Akkurat Mono more pleasant to use. DejaVu Sans Mono looks too dense compared to Akkurat Mono's softer looks.

Here is a side by side comparison: http://cl.ly/image/1j030D031g0U/o

Since people seem to care about it, I should also note that it has a nice slashed zero you can see on line 6 which I prefer to DSM's dotted counterpart.

Edit: Here's how it looks like when I adjust DSM's line-spacing to match Akkurat Mono's default, it still has that busy look: http://cl.ly/image/1z3Z393x1s3l/o
My first thoughts were: 1. Don't make customers login to make a purchase, allow guest checkouts and this will improve your conversion rate. 2. The homepage is too crowded, reduce the number of call to actions/buy now choices.
We know from studies done around 2003 done by peter provonost that if doctors follow certain checklists while doing an IV(if i recall correctly), reduce the complication rate from 12% to 0%.

Using checklists is still not a common practice among doctors.

What do doctors gain by not using checklists ? freedom, less boredom, maybe feeling of status. Is that the reason ? dunno.
Harsh.

I had a little back-and-forth with Violet Blue a few months ago. She accused some blogger of being egocentric in leading with personal pronouns. I defended said blogger, pointing out I do the same thing all the time, so as to give clues as to my thought process, the genesis of the post, and so on. She shot back a challenge that I should perhaps exhibit OTHER bloggers who do the same thing.

I found it hard to meet that challenge.
Science holds its practitioners up to standards and sometimes finds them wanting. If we didn't have scandals then that would be alarming. For many, many years there were no sex abuse scandals in the Catholic church. In retrospect, was that a good sign?

I don't see any sign of scientists being placed on pedestals in the US. What I see in the US is rampant anti-intellectualism, a cynicism about intellectual rigor, and cherry picking findings because they agree with ideological preconceptions. We're all guilty of it to some extent, but there are now a significant number of Americans who simply will not listen to well-reasoned argument.
I know it's an incredibly radical idea, but treating prisoners like human beings would be a good start.
Too late?

That depends on the size of operational overhead and opportunity of income.

If it's set it and forget it('ish), why not reap a few years income from a market that'll sell around 500M feature phones this year?
I was gonna say.... my first thoughts were : a) which algo, and b) which field should be hashed ...

....so in fact they're probably weeding out programmers who've done such things
Construct 2 makes it really easy, but I would like to see them add a way to easily put in multi-player mode.
The Kickstarter of Tees Takes on the Boyscouts
Who wins?

http://inktothepeople.com/marketplace/ink-detail/5683

Or continue the discussion here:

http://www.facebook.com/pages/Boy-Scouts-2013-The-Countdown-to-Equality/454227691322316
Solar Jobs Beat Out Ranchers In TX, Actors In CA, And Coal Miners Nationally
Exactly. ETFs, Index Funds, etc.

Besides, how did they get 2/3 anyways? If I make 7% and 2% goes to someone else, I'm still left with 5%. 5% > 2%. So how does that 2% translate into 66.7%?
I think it would be cool to watch them via a hangout like ui. That is, watch a movie while talking to people via webcam. It's not a the greatest idea, but it is more preferable to using FB to be paired with strangers to sit in silence and watch a movie with.
I am very ignorant here. Do you know if putting your 401K money into passively managed index funds typically results in higher fees than if you invested in similar accounts outside your 401K? That is, can you escape having extra fees inside your 401K?
Which you should do, then every penny over that you want to invest in retirement goes into your personally managed IRA.
Plant a tree in that fertile ground, and ... oh.
"The new frontier for crime is bitcoin fraud."

I don't know much about bitcoin but I'm intrigued. Could you please elaborate?
Can you put up the link to the code?
Just over 2 years, they bought it May 10 2011.

http://about.skype.com/press/2011/05/microsoft_to_acquire_sk...
Amazed how old Earth actually is compared to the estimated age of the universe. Also, about how old is primitive cellular life.
As for going into hospitals making you worse -- I agree from experience. One of my parents went into the hospital for a back procedure, and came back with her mind significantly diminished. She died 8 months later.

The other, in and out of the hospital, eventually died the same week, and one of his complications was MRSA.

Both were at Riverside Methodist Hospital in Columbus, OH, which I gather is a perfectly solid institution.
Truth is a little more than a random smattering of facts.
> The experiment — and others like it — didn’t give Stapel the desired results, he said. He had the choice of abandoning the work or redoing the experiment. But he had already spent a lot of time on the research and was convinced his hypothesis was valid. “I said — you know what, I am going to create the data set,” he told me.

> Sitting at his kitchen table in Groningen, he began typing numbers into his laptop that would give him the outcome he wanted. He knew that the effect he was looking for had to be small in order to be believable; even the most successful psychology experiments rarely yield significant results. The math had to be done in reverse order: the individual attractiveness scores that subjects gave themselves on a 0-7 scale needed to be such that Stapel would get a small but significant difference in the average scores for each of the two conditions he was comparing. He made up individual scores like 4, 5, 3, 3 for subjects who were shown the attractive face. “I tried to make it random, which of course was very hard to do,” Stapel told me.

This sort of misconduct is shockingly common in academia, such that it is often not even seen as misconduct.
>I wonder at which point it makes most sense to dump the fund and do just SPDR ETFs instead.

At any given point in time, an ETF will have the lowest fees compared to other options (mutual fund, professional money management fund, etc). There is no "breaking point" in which it makes sense to switch. If given your parameters, investment objectives and desired sector exposure tell you that an ETF and another option are possible, then at least from a "fee" perspective, it always makes sense to go with the ETF.
Ok guest checkout is a good idea, totally overlooked that. Thanks.

With the homepage do you mean just have the single deal. And remove the deals on the side?
Also, even the crappiest 401k plans have a few "passively managed" index'y mutual funds with relatively low fees (in the range of 0.1%/year) that you can choose.
This guy is dangerously naive. He seems to think (with ardent passion) that regimes in the middle east fell because "Twitter made that happen."

Okay, sir. Time to settle down and reel that nonsense back in.

He speaks emotionally about things that aren't necessarily tethered to reality and his facts aren't precise, and maybe he has the amnesia of a politician.

His message is that prisons are bad, and that we should rethink the manner of punishment we exact on people. His passion is very obviously motivated by personal experience, and that doesn't invalidate his message. Essentially, I agree with him. But. I'm not drinking his kool-ade about "OMG INTERNETZ."

Yes, I'll entertain his notions about prison being an inefficient and destructive practice that mostly leaves inmates as damaged wrecks, and possibly transforms many into more terrible criminals than they might've been without jail time. But I'm going to take his message with a grain of salt.

When I say dangerous, I mean it. He is too new to the internet, to extoll its virtues. In the same talk in which he absolutely RAILS against the privatization of prisons (which is an evil all its own, and yeah I'll agree with his points on that) his next words advocate just haphazardly dumping absolutely anything into the hands of large, corporate, profit-driven nigh-monopolies like Facebook. There's a cognitive dissonance in those two concepts that he very obviously hasn't thought deeply about (and to be fair, maybe he hasn't been given the time yet).

Which is surprising, I might add, considering that he's a man who had his mail read by prison staff, his phone calls monitored, and was displaced across 19 prisons during his time served.

He needs to acclimate himself with some of the debacles of the recent internet over the past 5 years in particular, and maybe familiarize himself with personalities like Julian Assange. If he can bring himself to understand certain realities about the internet, and how it can enable evil as well as good, maybe he wouldn't be so quick to proclaim that it's some kind of universal salve, which can cure all our ills.
Try submitting your question again later. To add some conspiracy sauce (and draw PG's attention), maybe Gild was a YC reject. Or even in a long term sense, YC's competitor. For what is to stop them from directing their algorithms at entrepreneurs instead of programmers? :)))))))
Try submitting your question again later. To add some conspiracy sauce (and draw PG's attention), maybe Gild was a YC reject. Or even in this batch. Or even in a long term sense, YC's competitor. For what is to stop them from directing their algorithms at entrepreneurs instead of programmers? :)))))))
WebKit only.
Really? The other elements (stopping once your data fits your hypothesis, ignoring contradicting data in analysis) are fairly common, but does any really think that making up data isn't misconduct?
Yes, actually. And to be more civilized when I disagree with them.

Edit: My standard response

http://eksith.wordpress.com/2013/04/08/diy-hashing-if-you-mu...
I am a big fan of Crafty. Glad to see it on the list I've used it successfully in a few projects its a great 'get shit done' game framework. Has an interesting composition inheritance model.
can you elaborate on this? most of the links i'm finding for self-directed 401ks are spammy.
Take your idea to the next level with the GetViable Lean Startup Process
> Code is an outline. It's not a spreadsheet. Column alignment is not beneficial in most cases

But there are many cases where code works best as a spreadsheet.

For example any time you need to initialise an array of structures, that is best viewed using a grid like pattern.

> but because I was really tired of reformatting multiple lines of code just because I'd refactored one variable or type name.
Any decent editor with smart indenting should eliminate most of that effort.

Also if the editor is scriptable editor, it should be possible to create a simple script to semi-automate the task.
I have no idea what "protein folding" does, but you just sold this story so well, that I'm about to look it up.

My point: great comment, makes me want to learn.
The real question is, what percentage of those people are willing to give up their culture and assimilate? It doesn't do anyone any good if Bangladeshis come to the U.S. and continue to act like they did in Bangladesh.

> In addition, the U.S. again tied with Germany in 2012 as the country with the highest leadership approval ratings in the world

Amidst cynicism about America internally, its good to remember that by and large, people world wide view it positively.
Can anyone shed light on how a paper is published? I am guessing the process requires some higher authority to review the paper to check for legitimacy. If so, he committed fraud in 55 of his papers, not 1 or 2! So what irked me while I was reading is, "how was fraud missed so many times?"

Someone else said that this is common in academia...if so, something HAS to be done to stop it. That's why I would like to know the process behind a paper being successfully published--it seems like a broken system if fraud like this occurs remotely often.
Has anyone seen a Matlab vs {Numba, Cython} comparison anywhere?
moved around a fair bit between DejaVu Sans Mono/Inconsolata/Consolas etc before eventually settling on Ubuntu Mono, which really holds up extremely well at smaller sizes (7/8 pt)
Not so much a process as a gravitational force. Different users pull it different ways.