This problem is due to the protection, the sandboxing.

Various approaches have been suggested on the online forums, including editing the config files to be more lenient about these protections (the so called "alternative approach" proposed by the poster)

I tried them all, never had any result. I almost gave up, then read about that safe mode reboot suggestion. I have long uptimes and I don't want to bother reopening stuff, so I didn't do it immediately.

But finally I did, and it worked. Based on the timestamp of my blog (http://en.blog.guylhem.net/) I tried that on mar 31, about 1 month ago, and here are the results from the syslog so far (1 month of data after the fix):

# bzgrep sandboxd /var/log/system.log*|grep deny|sed -e 's/.*bz2://g'|sort|wc
97 1441 18032

About 97 issues of sandboxing zealousness remain, if we distinct them by removing the PIDs with :

# bzgrep sandboxd /var/log/system.log*|grep deny|sed -e 's/.*macbookair//g' -e 's/[0-9]*//g' |sort|uniq
kernel[]: Sandbox: sandboxd() deny mach-lookup com.apple.coresymbolicationd
.guylhem.org sandboxd[] ([]): Preview() deny file-read-data /Users/guylhem/C/abcdef.jpeg
.guylhem.org sandboxd[] ([]): Preview() deny file-write-data /Users/guylhem/C/abcdef.jpeg
.guylhem.org sandboxd[] ([]): QuickLookSatelli() deny file-read-data /Users/guylhem/Desktop/Wolfram Science Summer School Application_files/.css
.guylhem.org sandboxd[] ([]): QuickLookSatelli() deny mach-lookup com.apple.PowerManagement.control
.guylhem.org sandboxd[] ([]): TextEdit() deny mach-lookup com.apple.SystemConfiguration.SCNetworkReachability
.guylhem.org sandboxd[] ([]): TextEdit() deny mach-lookup com.apple.tsm.portname
.guylhem.org sandboxd[] ([]): TextEdit() deny system-socket
.guylhem.org sandboxd[] ([]): VTDecoderXPCServ() deny file-read-data /Users/guylhem/Library/Preferences/.GlobalPreferences.plist
.guylhem.org sandboxd[] ([]): mdworker() deny file-read-data /Library/Filesystems/NetFSPlugins ()
.guylhem.org sandboxd[] ([]): mdworker() deny file-read-data /Library/Filesystems/NetFSPlugins (pre-ls-info fstype:mtmfs fsflag: flags: diag: uti:com.apple.application-bundle plugin:/Library/Spotlight/Application.mdimporter - find suspect file using: sudo mdutil -t )
.guylhem.org sandboxd[] ([]): mdworker() deny file-read-xattr /Users/guylhem/Library/Application Support/Google/Chrome/Safe Browsing Bloom (pre-plugin fstype:hfs fsflag:D flags:E diag: uti:public.data plugin:internalPlainTextImporter - find suspect file using: sudo mdutil -t )
.guylhem.org sandboxd[] ([]): mdworker() deny mach-lookup com.apple.PowerManagement.control (import fstype:hfs fsflag:D flags: diag: uti:com.microsoft.excel.xls plugin:/Library/Spotlight/Microsoft Office.mdimporter - find suspect file using: sudo mdutil -t )
.guylhem.org sandboxd[] ([]): mdworker() deny mach-lookup com.apple.PowerManagement.control (import fstype:hfs fsflag:D flags: diag: uti:org.openxmlformats.presentationml.presentation plugin:/Library/Spotlight/Microsoft Office.mdimporter - find suspect file using: sudo mdutil -t )
.guylhem.org sandboxd[] ([]): mdworker() deny mach-lookup com.apple.PowerManagement.control (import fstype:hfs fsflag:D flags:E diag: uti:com.microsoft.excel.xls plugin:/Library/Spotlight/Microsoft Office.mdimporter - find suspect file using: sudo mdutil -t )
.guylhem.org.home sandboxd[] ([]): Preview() deny mach-lookup com.apple.SystemConfiguration.SCNetworkReachability
.guylhem.org.home sandboxd[] ([]): Preview() deny system-socket
.local sandboxd[] ([]): QuickLookSatelli() deny mach-lookup com.apple.PowerManagement.control
.local sandboxd[] ([]): VTDecoderXPCServ() deny file-read-data /Library/Preferences/.GlobalPreferences.plist
.local sandboxd[] ([]): fontworker() deny mach-lookup com.apple.ls.boxd

This last one is interesting :

# bzgrep com.apple.ls.boxd /var/log/system.log*
/var/log/system.log.2.bz2:Apr 26 18:23:37 macbookair.local sandboxd[64] ([62]): fontworker(62) deny mach-lookup com.apple.ls.boxd

lsboxd sqweaked only once in a month - and for something different.

I'd call this "problem solved", which is supported by my personal observation over this last month : I haven't experienced the problem again yet, while previously it was at least every 2 days (along with the TimeMachine always reindexing)

My suggestion: check your logs with the greps, try this simple fix and report your results in a month.

EDIT: This in on my macbookair with a 480GB OWC SSD (but apparently it also occurs on macbookair with vanilla apple ssds). I used istat menus, and still do. I didn't disable the dynamic pager, spotlight or anything else.

(EDIT2: removed) - thanks for the 4 spaces suggestion! as explained, the simple safe reboot solution made the problem go away, while other approaches didn't. It works for me, and I have 1 month of data supporting that.