skysight-inc/HackerNews huggingface dataset:
I would support such a system. In my ideal world, things look like this:

NIH pays for the research and development of new drugs, and we do not give out patents for any of it. Pharmaceutical companies are free to produce whatever drugs they want, and cannot prevent anyone else from producing those drugs; they must only meet the quality control standards set by the FDA. All drugs would be sold like today's "generics," in a competitive market that keeps prices down.
If my age becomes an issue for clueless employers, I will work only remotely, join the matrix, and become my github account.

My face will not be old and haggard, but digital, expressive, cleanly coded, and handsomely tested.
Show HN: Akṣi - Handwritten-digit-recognizing neural-network
i dont think the 25 yo understand the internet "on a different level" because they are born with the internet. Using something early doesnt mean you understand how it works at all. Young people may learn faster though, but older people are supposed to know more already.
But the point is that the triggering mechanism is only unknown and hard to trigger to folks outside of Apple.
haven't been following too much on foursquare, but sounds like it is a prime target for acquisition by Yahoo.
Your ability to retire is tied to your financial situation. What does that have to do with the government?
That's actually backwards. Since each round is independent of the last, collisions on an intermediate step will propagate forward. Since each round has the same chance of creating a collision, more rounds means higher total odds.
Over 50 here. You have to create your opportunities. Want something interesting to work on? Create the project, work on it in stealth. If it works out, it may become an official project and you increase your status.

Cultivate your interests. Learn something new. Coursera is pretty awesome - I wish I had more time for all the courses I'd like to take. The courses at MIT's OCW (and edX) are great. Download lectures to your mobile device. Search iTunes U for classes.

Write short programs for fun. Check out Project Euler, fer instance. Don't forget why you started programming in the first place.

Gear up and get a new job. Don't accumulate too much dust. Crack open a book about interviewing, get off your high horse about what people consider fair game in an interview.
Yes: BTC-e, Bitcoin-24, bitfloor, Bitstamp, CampBX, VirCurEx

But MtGox gets something like 80% of all trades.
Nice example. Of course the challenge is to verify that the one-way function actually yields information about the starting word. As an example, a conceptually similar procedure with Wikipedia usually winds up at philosophy.

See http://www.geekosystem.com/xkcd-philosophy/ for more.
Have any tips for getting out of Mode 1?
I wrote this about two years ago from scratch for an algorithms class. I didn't know much about neural networks other than the fact that they tried to mimic how neurons worked in the brain. It was a pretty neat learning-experience. Thought I would share!
I'm curious how one writes software to link in as an exchange. I haven't read the Bitcoin code throughly, but I'm not sure if I understand how to initiate a transaction with the network. Is there anywhere that documents it well?
Not really. You're saying "I authorise exactly this amount of money and no more", and if they then take any more or don't deliver the service it's fraud, and you're protected from that by consumer credit law (at least you are here in the UK).
> I've never had to do "maintenance", write CRUD apps,
> had horrible bosses or worked with bad developers or
> unpleasant people.

I wondered what you have been doing, so I checked your profile.

> I spend my week days working on
> Windows/WPF/C#/C++/machine vision applications for
> aiming lasers

Sounds pretty fucking cool!
More accurately, Medicare is not allowed to negotiate for drug prices, however, the don't pay more than the average selling price for a drug (ASP).

Medicaid is certainly allowed to negotiate over drug prices. Medicaid gets an automatic 23% off the drug price and if the states can get an even bigger discount, they often get to keep it.
The non-reversibility of bitcoin transactions is a huge liability. Our current state of software technology was designed in a world where the most valuable/dangerous thing you could possibly have on your disk or on a web site was, what, your ssh keys? Nude photos of yourself?

The value of hacking, phishing, etc is significantly increased by the presence of bitcoins.

I guess you could argue that if bitcoins are popular, software practices will evolve to be much more secure - but until then, it's wild west, and much more wild than the internet ever was before.
Thanks for the semantic qualification, I agree completely.

Not paranoid in the usual definition, but quite pertinent to the Jobs ideal.
what will increase your odds of success is to work smarter and have better hourly output than your competition (whatever is appropriate measure of 'better' in your case). Working long hours should be your last resort not your first how to succeed. Yes I do understand that longer hours compensate lower hourly output but I would argue that you should find area where your talent lies. If you are in top 5% in given field that is enough competitive advantage without putting more then regular hours. IMNSHO Reason why most startups fail, there are not enough hours in a day to compensate for a lack of innate ability to do job.
Has anybody seen their bulletins? Their first one advised people to go celebrate their "success" by drinking Champaign. Never mind that their exchange just lost ~half of its net value. Yuck!
>Young founders don't trust you because you don't know the latest technology that has come out in the past 2 years.

Then the young founder is wrong. I'm also 38, and not only am I familiar with (intimately in many cases) with 2 year old technology, in many cases I'm in the process of _creating_ the future of technology (in my particular slice of computer science).

You may be on to something with fads, though. My experience (purely anecdotal) is that more experienced developers are better able to pick out the fads vs. new tech that's likely to stick. That makes a difference. I'm not going to spend much of my valuable time on something that I don't believe is going to last, and after 20 years, I'm pretty good at picking those things out.

I have a very long list of things I want to have a deeper look at, but I'm not going to waste my time on technology that won't last. Oh, I'll have a look at those things (the high level that you mention), but that's as far as it'll go. There's far to much on my plate.

On occasion, I do get it wrong. That thing I thought would be a fad, ends up becoming important technology, and I have to play catch-up, but that doesn't actually happen much these days.

I guess my point is, it may appear that we, older developers, lag behind, but really, our experience allows us to make better decisions about what technology to spend our time on.
My point is that "how it works" isn't that important. "What it changes", is. I was in college in the pre-Facebook era, so I don't really have a handle on how different it was to have access during college years. Now teenagers are Snapchatting each other, and I don't do that either- so I don't understand the behaviour as well as younger people than myself.
I like the idea, but the layout is pretty broken in non-Webkit browsers.
RC plane gets a balloon lift to space
From what I understand, it wasn't all pure venture debt, but a split between convertible debt from insiders and venture debt from silver lake. Given silver lake's place in the capital structure and likely covenants, if foursquare is still burning a ton of money with minimal revenue in 6-12 months they probably can be paid with the new money from USV / Spark / a16z.

And in order for this deal to work out for anyone, the $2MM/year figure is going to have to be much larger. With 6.0 you can already see Twitter and Facebook esque promoted ads, which are going to make that figure grow a fair amount in my opinion.
Leading the Charge for Impact Investing—Do You Invest with Impact?
Confidence may be quiet, but quiet has never been marketing.
It costs tens of millions of dollars in large part because US healthcare is so expensive. The actual handing out of drugs is fairly low effort, it's everything else that makes trials so expensive.
$60 on BTC-e
Heh, so there are. I've never seen those before, outside from special test installations. I didn't think they were even cleared for public roads.

Thanks, interesting links. I can't seem to find a locations where I could buy one of those though.
Easy to test, go repeat your comment here:

https://news.ycombinator.com/item?id=5532040

https://news.ycombinator.com/item?id=5532358

https://news.ycombinator.com/item?id=5532380

and let’s see if you get the same reaction for deriding the wisdom of the almighty Kōzuki-San.
Anyone can grab my cell phone from my desk. But if I log into the website, I can lock and remotely wipe it, as well as tell the police where to look for it. I can even take pictures of the person who stole it, completely unbeknownst to the thief.

Some might say the best security systems are the ones the thieves don't know are there.
Sold launches an online broker app for selling gadgets
That user was aware of extra MtGox security and chose not to use it.

On top of that the user

1) Chose to turn off (or not use) malware software

2) Enabled Java in the browser

3) Chose to visit a short url link presented in a chat window

4) Clicked through a big scary warning

All while still logged into their MtGox account.

It sucks that they're a victim of crime, but their actions were dumb.
Awesome. I'm buying back in at $8.
Ok how about the classic mixing two colors together.
Don't Blame Apple: The Evolution of Gay Sex in Comic Books
There are several other online exchanges [1], Mt. Gox just has the majority share by volume in several currency markets.

There are also many other informal exchanges, including in-person transactions and ebay.

[1] http://bitcoincharts.com/markets/
How do you find remote work? Are you a contractor or permanent?
I guess the Apple engineers would have prepared the demo and analysed the copied ROM, before going to the court. Then, they would have found the routine (somewhere else, as you point it out) and easy to activate.
Being Bold
The only boring parts are the parts below Michigan/Chicago, particularly Indiana... it's basically one giant field.
Boo, hiss. Taking marketing at face value is holding a weed whacker by the wrong end.
http://www.smbc-comics.com/index.php?db=comics&id=2722#c...
I got the small IT consultancy I work at using hipchat, we love it! The main reason I wanted us to use hipchat versus the conventional IM'ing is for this exact reason!

One thing hipchat needs to work on though is that when you use the search functionality on the windows air app it really just opens a browser windows with the results. This is a little clunky and irritating i think!

Going a step further it'd be nice to easily be able to select snippets of conversation and tag them for later reference or even perform other actions like emailing them.

I hope hipchat continues to develop more functionality that bridges the gap from synchronous communication to asynchronous for utility such as this.
"I don't know how people can still write coherent code at that point." - they don't and that is a problem
I've never found the inconsistencies in the API the major learning hurdle for git. If that's the case then it's really too bad since, as you mentioned, it could have been avoided.

For me the hurdle was not the API. That's what documentation is for. It makes learning it inefficient to always check the docs but that's about all.
Because in healthcare you don't give what patients want but what they need.

Where's the line? Maybe I don't "need" a new prescription painkiller with substantially fewer gastrointestinal side effects than the OTC one I'm taking, but if it would greatly improve my quality of life, I certainly might want it. Maybe I'm lucky enough that I see my doctor regularly and he keeps up (without any pharmaceutical marketing?) on every medicine that might help me out, but why should consumers be force to depend on that?

The idea that there are hordes of people making doctor's appointments to demand brand name drugs they heard about on TV, and doctors are "forced" to write what they consider useless or overpriced prescriptions for these drugs seems silly to me.
Presumably Apple would be able to disassemble the clone ahead of time and find where the address had moved to.
No it isn't, none of Microsoft's competitors from the 90s were anything near its size.
My problem is that my company (and I don't think I'm alone in this) is ill-equipped to handle the career path for programmers in any other way than to force them into management. I've been resisting it as hard as I can, but I'm already growing weary due to factors such as the "team lead" title which instantly gives extended benefits -- like an added week of vacation -- among others. My path also upsets the existing chain of command, since I'm outside the norm, and so I'm treated like floater that just kind of gets bounced around.
The secret to successful online learning
Simply put: if the board doesn't maximize the interests of the shareholders, the board will be replaced by a board who does. Because of this control mechanism a public company will always take care of the shareholders first before anything else.
The saying goes, never attribute to malice what can be explained by stupidity.

But they also say, just because you're paranoid it doesn't mean they aren't after you.

So I'd say this may very well be the authors of the malware astroturfing and trying to fool others into ignoring it
I think a big part of it is that the "young founders" are naive and don't know what they don't know. This allows them to strike out in unexpected directions and try things that no one with experience would actually do. Usually, they will fail, simply winding up older and wiser. Occasionally, however, they will succeed, possibly through nothing other than luck, and that makes them look like a genius.

Now, I don't mean to belittle the inexperienced young founders; we were all inexperienced once. Also, a few of them probably truly are visionary geniuses (but I suspect most are not). All that said, many of the start-ups I hear about sound ridiculous to me, and most will fail. The few that are destined to truly succeed, however, probably will also sound ridiculous to me. And perhaps, that is why "young founders" are occasionally going to change the world.
You have to give it a few minutes for people to get their replies out before you get antsy about downvotes. The same time you posted this, multiple replies were pouring in.
So useless to everyone else... It's basically an ad-hoc DRM solution that gains no advantage to the end-user, while triggering un-known actions in an otherwise trusted piece of software.
Raised over $112M to date. Talk about a cash sinkhole.
I agree that the user is largely at fault here, but would you consider this acceptable if the same thing happened on your bank website?

I'm not familiar with Mt Gox but it's unacceptable if they don't have two factor authentication.

EDIT: Scrolling down, it appears they DO offer two-factor authentication. nvm.
Jason Gelman • Reactions To Foursquare Funding
> Build what, though?

It's part of being an entrepreneur. You have to keep thinking and keep looking for ideas consciously. It's a cultivated habit.
Experimental Videogame Teaches Kids How to Program Java
To get the drugs past the FDA you only need to show it behaves better than placebo

Not really. You need to show how it works compared to the current regimen.

If someone suffering from a disease currently takes drugs A, B, and C, and you have what you think is a better C (let's call it C++), then the study would compare people on (A,B,C) to people on (A,B,C++).

Unless there is no treatment at all for the disease, in which case, go for the placebo.
Hopefully this will move some of the trade volume on other markets. Having most of the trade of a decentralised currency on one market is not a good idea, and I see it as something that goes against the idea of decentralisation.
It took me almost 20 years of hardcore programming to realize it wasn't the programming that was interesting to me. I didn't give a whit about new languages and frameworks and new design patterns. What I cared about was the creation of something from nothing. What I cared about was the ability to conceptualize and immediately materialize: ideas leading to moving digits on a keyboard leading to product.

Starting my own company, releasing my own software, interacting with my own users and reveling in their praises or reeling back from their complaints: that's software brought to life and that's what keeps me going.

Programming is just the canvas for getting my ideas out in the real world in the hands of real people.
I wonder if this sentiment is similar to the "no one uses Hotmail" type comments I hear from tech people. It seems like lots of people still use it based on the number I check-ins I see. It may not be quite as trendy these days but it's definitely gone mainstream.
Here's timelapse of a Florida-to-California helicopter flight: https://www.youtube.com/watch?v=gz-e0dSwjnA
Samsung Android Screen Sizes
I don't see the logic of raising $41M for a company that doesn't need it to buy equipment, raw material, real estate or physical stock of something.

Unless your revenue model is to do 5 rounds of financing and then move on to the next startup.
What's wrong with CRUD apps?

Has CRUD become a derogatory term, or do you just personally feel that they're boring to work on?

Tons of useful applications involve Creating, Reading, Updating, and Deleting database records at their core. Facebook and Twitter are essentially giant CRUD apps, so is every CRM system ever. Rails and similar frameworks provide scaffolding for automagically building functioning bare-bones CRUD apps with just a few keystrokes, relieving developers of the boring, repetitive part and freeing them to work on the unique business logic.

I dunno, maybe I'm a dork, but I guess I kind of think CRUD apps are cool.

Edit: OK, I admit that they're not nearly as cool as machine vision for aiming lasers, though. :)
Not when the snail mail is in an envelope. When you send plaintext email, you are exposing the entire body of the message to casual inspection by any of the mail servers that are involved in delivering it. Unlike the postal system, however, your email is copied and stored by the servers involved in sending it, and you have little control over how long it is stored.

It would be as though you communicated by sending post cards, and the postal works took every post card and ran it through a copy machine, leaving them all in a neatly organized (by sender and receiver) pile somewhere.
Introducing Lanyrd Pro, for companies that speak at and sponsor events
Might've been effective as a deterrent.
Is there anything that makes this unique to an Android phone vs a bog-standard laptop with wireless?
There are so many weasel words in "basic research to discover new drugs" that I can't even begin to evaluate it.

Or, you can look at the actual drugs that get approved, and back-trace them to their sources. Hey, someone already did that. Here: http://pipeline.corante.com/archives/2010/11/04/where_drugs_...
I agree with you, however in most cases debt is cheaper than equity, and it is an alternative that is rarely looked at by founders. Entrepreneurs take VC terms at face value without thinking twice. As the space gets more and more competitive with non-traditional early stage / growth investors (i.e. hedge funds, strategics) I believe we will see a lot more creative deal structures and terms that are more favorable to entrepreneurs
I suspect this benchmark is actually just testing the difference between STOMP and AMQP. RabbitMQ with STOMP is in the same regime as ActiveMQ / Apollo while RabbitMQ with AMQP is always 3x-5x faster than itself and others with STOMP.

QPID is the only other AMQP competitor and it seems to have performance issues with persistence but the transient performance is always in the same regime as AMQP RabbitMQ.

STOMP is a UTF-8 text protocol while AMQP is a binary protocol. This means that every message you send using STOMP requires encoding it in a safe-for-text format (e.g. base64 encoding or similar. I'm not intimately familiar with STOMP).

Going on the hypothesis that a STOMP message parser is much slower than an AMQP parser, this would explain why RabbitMQ AMQP does not perform well in the 200 message case while it trounces in the 20k and 200k message case. In the 20k/200k message case the benchmark is mostly looking at time to decode 200k text messages versus 200k binary messages.

It's so exceedingly hard to do a benchmark and measure the thing you think you are measuring.

Also, I agree with others that the minimal difference between persistent and transient setups is very non-intuitive. The author left out an important detail of whether he was using an SSD or not. Otherwise, I suspect an error in the measurement setup.
Way to take a decent (if prosaic) point, crumple it up, and toss it in the garbage. You say all this stuff as a preamble to implying that Apple, specifically Apple, lacks confidence in their products? Mystifying.

Take this silliness to its logical end -- Apple shouldn't advertise their products at all. If that's what you think... I dunno what to tell ya.
At least tulips had some innate utility.
The first comment after the article ends the discussion:

"This article is misleading from the beginning. India did not refuse to issue a patent for Gleevec, it refused to extend the patent Gleevec already had, based on merely superficial changes to the formula, a practice known as "evergreening", which pharmaceutical companies use to extend the monopoly on their medications as long as possible."

That is completely accurate, and more informative that the article in fewer words.
TCAS is a completely automated system. When your TCAS issues a Resolution Advisory, pilots are expected to do the following:

* Shall respond immediately and manoeuver as indicated, unless doing so would jeopardize the safety of the airplane

* Shall follow the RA even if there is a conflict between the RA and an Air Traffic Control (ATC) instruction to manoeuver

(http://www.eurocontrol.int/msa/gallery/content/public/docume...)
I think that you're addressing a real issue for job applicants, but not sure about the domain name.
Find a cheap resource who can do the sourcing work for you. I know startups who hire interns (for free!) and have got the database ready.

In your case, can you get a team of interns to get a list of hotels and the email ids of the right person (GM or atleast the front office manager) ready. Getting hold of 10K email ids is probably a weeks job if you get 2-3 interns.

Then there are these email marketing companies who give you free emails ( You are a startup, look around, you will find deals)..

In a week if you reach out to 10K hotels, even with a 0.1% conversion, you make some money. After you do it 3-4 times, you would start making enough money to start arranging your sales force.

PS : Interns in Eastern countries need to do live projects as a part of their MBAs. This helps them have a better chance of getting a job.
I am personally employing couple of interns for totally different reasons. :)
Meet Donna, Your Mobile Personal Assistant
We've been using CUDA to speed up Monte Carlo pricing for years now. :) Writing in Python does make it more accessible to more programmers. I'm curious how much overhead is added.

http://www.wallstreetandtech.com/it-infrastructure/bloomberg...
dunder is a wonderful way to pronounce "double underscore" methods. It saves a lot of time and syllables.