skysight-inc/HackerNews huggingface dataset:
That sounds like a doctor's job - they might prescribe a fairly cheap medicine, but knowing what kind of medicine to use is a different art entirely.

Here the only reason why the company is able to charge a large amount of money is because they've gone through the whole process of tests and clinical trials to get the drug available for consumption. That's an entirely different kettle of fish than the expert knowledge $9999 you mention above.

The gist of the article isn't about expert knowledge, it's that a fairly simple chemical compound (the name itself gives the simplicity away - dimethyl fumerate is too short to be anything horrendously complicated) is jacked up in price, and that someone suffering from the disease could presumably get the drug made themselves for much less than $50,000 per annum.
How does a cabbie make money?
…future expansion that I will probably never use. And I disagree that it's just as simple. I think that CBV's encourage me (and my team, because I'm not working in a vacuum) to think about the problem all wrong. You may like thinking of the problem that way but for me it's like trying to think of a song while another song is playing. I usually think of Django views as a function, not a method on a class.

Django's FBV's are far from perfect and I think they really could benefit from some small changes to the way things are done, but I agree with the above links that CBV's were a step in the wrong direction.
The Most Dangerous Countries for Tourists, In Maps
This "young'in" seems to be learning ... with a few more insights we'll have to promote him to management so he doesn't accidentally share this knownledge with anyone.
Perl and Perl Module Administration in the Modern Era
AppCode. It's what this new IDE is going to be based on.
That's complete nonsense. Nanobots cannot repair angstrom-scale freeze damages. You approach the classical limit, where protons are more wave than particle.

And what's a brain antifreeze? Even biocompatible antifreeze proteins found in arctic oceans have a thermal threshold of 269K, which is no where near cryogenic temperature.
That would be nice. :)

I take into account points and karma of users to build list of top items.
Everyone that lives that we know of dies eventually. While I would prefer to live as long as possible I think it's important to recognize that. And trying to pitch a 200K solution to a problem that isn't really a problem but rather the nature of life strikes me as inappropriate. If you are that hellbent on this 'solution' send the email directly to the author, but your response smells like a sales pitch which makes me ill. I would downvote you if I could.
Actually, I dont' think noscript/notscript will block this. It blocks loaded javascript, not inline stuff.
This news puts his last two novels, Surface Detail and Hydrogen Sonata, in an interesting light, the former being about virtual hells and the latter being about a species transcending[1].

[1] http://en.wikipedia.org/wiki/The_Sublimed
Posted this separate, but I'm seeing the following users/metros in my request logs

c-75-65-181-xxx.hsd1.la.comcast.net West Monroe, LA

c-174-52-141-xxx.hsd1.ut.comcast.net Provo, UT

c-69-137-179-xxx.hsd1.az.comcast.net Tuscon, AZ

c-76-109-127-xxx.hsd1.fl.comcast.net Miami, FL

cpe-72-225-230-xxx.nyc.res.rr.com New York, NY

c-68-48-154-xxx.hsd1.md.comcast.net Washington, DC

c-98-224-83-xxx.hsd1.ca.comcast.net Fresno, CA

c-66-41-214-xxx.hsd1.mn.comcast.net Minneapolis, MN
I'm a product optimization specialist. I'm responsible for my company's product split testing efforts.
The more I've learned about how the medical system works, the more it seems like the future is going to tend towards replacing doctors with systems like Watson, concentrating knowledge in a quick, easily updatable form and keeping doctors around for patient comfort.
Many have problems with the title. It may be interesting to note that Jake Lodwick ‏@jakelodwick stated:

"I wrote an article for Pando. My suggested title, “A Critique of Popular Ambition”, didn't make it."

ref: https://twitter.com/jakelodwick/status/319330932945469440
The blog post seems to frame the issue as:

"Should this company be allowed to make massive profits off of their investment in clinical trials?"

Any reasonable person would say "Sure they are allowed to make a profit off of that." I don't think there's going to be much objection to that question.

But that's not the real issue, and I think if the author is honest he knows that. The real issue is:

"Should MS patients, many of whom are poor, be forced to pay $50k/year for medication to help with their condition."

The answer to that is obviously no. Now you can say that the insurance company will take care of it, but that's presuming people have insurance and that the insurance company isn't going to dump them, they're not going to have a deductible they can't afford, etc.

When it comes to medicine, ethics have a larger role to play than say, home decor.

Anyone who doesn't acknowledge that is being disingenuous.
Why would you ever yield return a single value?

Thats a special case in the Unity game engine as the Update() functions of each script are called in the Game loop once per frame. Now if you do a WWW Request without yielding out of the game loop, the game will hang in that frame until the WWW Request is finished. By yielding it does the WWW Request asynchronous outside of the game loop and comes back to the Debug statement when the WWW Request is done.

I share your view on the incosistent Code Style though, it should be PascalCase all the way and i have always done it like that in Unity projects.

Public fields are another thing special to Unity, as you are able to modify public fields directly within the IDEs Object Inspector, which allows you to modify values while testing the game for example. You can also use Properties but those wont allow you said Inspector modifications (at least in Version 3.x that was the case).
Very sad, of course. He's only 59. I've gotta admit that I'm also a bit angry. The war on cancer is 40 years old and we are still so far away from solving the problem(s).

http://en.wikipedia.org/wiki/War_on_Cancer

The first commercial microprocessor was released in the same year:

http://en.wikipedia.org/wiki/Intel_4004

Solutions? Ideas? The list in my mind is starting to get painfully long:

Randy Pausch (47), Steve Jobs (56), Ian M Banks ...
Wow, that is certainly an interesting calculator.

* Going from the $10k CA incentive to the $7.5k other states one changes the monthly from -80 to -11? Is the incentive sunsetting or something?

* The default settings assume you are using it for business and can deduct the cost. Just unchecking that makes it significantly more $$$.

* The gas savings assumes your gas car gets only 19 mpg and requires $5 gas.
Off-topic: For anyone interested the guy who wrote this post also has a hilarious section of his blog called "Things I won't work with" http://pipeline.corante.com/archives/things_i_wont_work_with... which documents various insanely dangerous chemicals along with very humourous descriptions of their history, usage, what crazy people tried do do with them and in what ways they have killed people.

You do not need to be a chemist to appreciate it.
Do kids in the Barrios these days have access to Android phones?

It would be good if at least some of them can get to information and bootstrap some education / skillset from there.
Douglas Hofstadter has a new book
This is sad news, and there is really nothing to add to his own words.

I just want to highlight two things, firstly his support for the NHS, which despite every newspaper and politician gunning for it still usually manages to deliver top quality care.

Secondly, can we leave off the cryogenic stuff ? The guy is dying, and pretending it will just be a pause is insulting all round. This was a touching and accepting note written by a skilled hand - and he is not blathering on about the next life. Please leave it be
Great idea! I've added it to bookmarks. Yes, I think it's ok to put affiliate links.
Ok, now the question is...

... how I can make my own crypto-currency?
I bought the stocks before ;-)

Seriously now: ZNGA is ~10% up now and although the stock price of Zynga implicitly has this information, since it is a risky stock (not Apple launching the iPhone I) there is an opportunity for buying it, even later.
Whole galaxies die, what to say about us poor humans, please do not offend basic physics with this "other option" thing, if there is a single certain thing in the whole universe it is the certainty of change and, as a consequence, death. We might extend lifespan greatly, it is a different thing altogether, it is worth discussing, it might even be a good thing, I don't know, but clinging to a dream of immortality will in my opinion sooner or later lead to a mental breakdown for most people who choose to pursue this path, latest when confronted with serious disease or dying.
Despite the strident tone, I never said otherwise. My defense of the language is based on the people I've encountered who speak it.

It's like, I personally don't like rap, but I wouldn't begrudge others who do because they see something special in it that I simply don't see. I used to, until I realized it wasn't simply that people were being "stupid" by listening to rap, but instead that I was missing what they were seeing.
Fair enough, it was a little bit of provocation. As I said if you like maths and programming, just design trading algorithms for them !
Any currency as volatile as Bitcoin or Litecoin is right now is worthless, because it's too unstable to do meaningful business transactions with.
When I said outlier, I actually meant the type of work I do. From the discussions here, most people don't do enterprise software development and especially non-web development. I'm pretty sure there are developers that make a lot more than I do but yes, I agree that I do make a lot of it and am grateful for that.

I also agree with you on the whole culture around not discussing your salary. I've worked in other countries and it's a normal question a friend/colleague would ask.
I'm actually just starting reading a book from him. The first I'm reading from him. That's sad.
The brain is like flash memory. Sure some of the conent is still possible to get at (electrical charge stays around for a long time) but the circuits between the flash cells are all dead. The connections are as important as the state.

Not going to happen.
“I was an iPad skeptic”
Interns Left Behind During SXSW Still Wandering Streets of Austin
Everything has a risk, but not all risks are equal. You seem to be saying "no point in closing or even locking the door, just leave everything wide open and put up a sign saying 'please do not enter'; it's the same, as everything has a risk." Is the difference in risk clearer now?

As for the example, SSH (or most other remote access solutions) has much more secure modes of operations than MySQL (or any other database) - which shouldn't really be surprising. One of these products is a database (where security is just an afterthought), whereas the other is a tool for secure remote access (where security is the main goal; unless you're the type of user who's blindly clicking "yes yes yes agree yes agree sure yes yes," it's very hard to break SSH).

If you insist on deploying insecure systems, that's mostly your problem; please don't advise others to do likewise (as you're actively causing harm by this).
Sorry, I thought this was an April Fools!

I saw "Infinitely Faster", and though uhh huh, of course. Then I clicked to the next page and "Note: Cap'n Proto is not ready yet" made me even more sure... only when I came here was it clear that the technical discussion wasn't a continuation of the joke!
Qt, friend, Qt. QT is QuickTime.
We'll likely all die from overcrowding problems in the end anyway... Solve all the diseases you want, but we'll all die at some point.
If the concept only works when we're relying on full-brain scans and future nano-bots with the capability to reconstruct brain tissue, the freeze/thaw would be completely superfluous.

Why not cut out the middle-man? Just do a full brain scan and store the digital data until the nano-bots arrive? Then just recreate brains within stock bodies or some virtual/machine environment?

Clinging to the freezing and thawing, when you're forced to concede they won't actually work and then having to invent far superior technologies, but only applying them as a band-aid over the broken technology, looks an awful lot more like someone with a belief grasping for intellectual cover, rather than someone with an intellectual understanding positing solutions.
That was what seemed like the crux of the article to me: get 650,000 Youtube subscribers. Taking that as a premise makes anything after seem like cake.
Is it just me or is BTC-E (Cloudflare error) and MTGOX (was not able to login) currently under heavy load?
Every single release of OwnCloud includes security fixes. From XSS to SQLi. I have very little confidence in that PHP project from a security point of view.
I think lisper's link refutes that - to my untutored eye, that is a bench experiment as a patent application.
ISP Advertisement Injection - CMA Communications
Qt's moc is a preprocessor/code-generator which compiles to standard C++.

Do you also tell people that they shouldn't use flex/lex/bison/yacc/antlr/etc.? Why are those code generators/DSLs acceptable but the moc is not? It's not as if the Qt authors added it because they don't understand C++, they added it because it solves a vexing problem in C++ GUI design.
He/she probably worked on the control systems that allow cells to be locked/unlocked from a central point, or something else that mundane. Not some pie-in-the-sky system that determined guilt, which would seem to be where your problem lies.
I don't think it'll be that high? I'm not sure. I've heard closer to $130k.
Korean Words for TOPIK Beginner 08
Such sad news. Mr Banks instantly became one of my favorite authors after I read his SF novel Player of Games. Then I read The Wasp Factory, which cemented his status on the other side of the fiction fence.
Online html5/canvas music sequencer with Delaunay triangulation
Not exactly. They're recreating a lease in a way that subverts the tax code. Clever. I wonder if the government will allow it to continue.
Mark Zuckerberg's first website is still on Angelfire
http://www.angelfire.com/ny/mez51/
I would; death sucks. At the very least, people should always be able to choose to live for another day.
The inventor.
"Once again, the conservative, sandwich-heavy portfolio pays off for the hungry investor!"

(Sorry, you saying the pizza will still be worth relatively the same as it was before reminded me of this)
Ultimately I think people are more annoyed that they don't get to choose to hang on as long as they'd like. Sure its a bummer, but for gods sake be grateful for any time you do get.
People still struggling to accept life.

Man grow out of this world, created awesome books, then he changed to something else. World as it is, is because he is.
Yes, I will be in Seattle. Sadly we still have to pay the state taxes of our tax home, so the tax rate of Washington versus California doesn't really affect our pay.

However, It's only negligible if it doesn't correlate linearly with a starting salary.

If my starting salary is 20% lower at Amazon than anywhere else, you can bet I won't be returning after my internship.
<META NAME="Author" CONTENT="Mark Zuckerberg">

Created when he was 15 and living with his parents in New York.
Anyone have the coordinates to the site?
What can we as a community do for him?
Video: 464XLAT live demo (making IPv4-only apps work over IPv6-only networks)
If you'd like to mine Bitcoin, this is a pretty good guide:

https://docs.google.com/document/d/1Gw7YPYgMgNNU42skibULbJJU...
3 Tips for Attracting a Technical Co-Founder
Great post, finally someone that you'll read about has finally said it. Isn't it demeaning to name every helpless or copycat project as a "startup" ? Next step, show this to Techcrunch.
This is a bit off-topic, but if you enjoyed his writing on this, I would also recommend perusing the category "Things I won't Work With"[1], but maybe only if you have the afternoon free. It's a hilarious compendium of chemicals that are simply too unpleasant to work with for his tastes. For values of unpleasant including explosive, smelly, corrosive, or some combination thereof.

I'm not a chemist, but his tellings of not just how things could go terribly wrong once you have the substance, but the myriad ways it can wrong merely trying to make the substance had me in stitches for the better part of an afternoon.

Then again, I was always the one setting stuff on fire, breaking glassware, or trying the reaction with more reagents in high school chem lab, so maybe it only appeals to me...

[1] http://pipeline.corante.com/archives/things_i_wont_work_with...
Meh, my bad, a little factor of 100 goes a long way.
IPad got a girl interested in me
It's good that this discussion can actually be had on here civilly. Too often I see vitriol and pedantic disagreement on HN for no reason other than the swinging of the e-peen.
From the spec:

• External interface is multiple 10-15 Gbps SerDes interface, each with 16 full duplex lanes. (The 320GB number comes with 8 10Gbps links, the 4 link device is 240GB/s (higher clock rate))

• Internal ECC for memory, packet based interface with CRC and retry.

• Built in self test, there can be spare resources which allow it to replace failed sections.

Envision a city on a grid filled with sky scrapers. The ground floor of each skyscraper is the logic, called a "vault controller", each floor above is DRAM storage. The city is constructed by laminating chips, one for each layer, and the sky scrapers form their connections vertically through the chips.

There is a switching fabric that connects N serial links to M vault controllers.

• 16 vaults in the 4 link version, 4GB. 32 vaults in the 8 link version, 8GB.

• A single vault controller can be servicing many serial links simultaneously. It can prioritize. Within a single link, requests will always happen in order.

• There is a router system which allows up to 8 cubes to be on the same host link to increase storage per host link. Link length is limited and power demands are higher for longer links. I think the router will allow shorter links to be used, especially in multiple cube modules.

• Atomic bit write and atomic add transactions. New options for the lock free algorithm folk.

• 31mm^2 BGA. 4mm tall. For the 4 link device. About 900 pins. About half are grounds, 1/4 of the remainder are powers, the rest signals.

• 7 different power supplies at 4 different voltages required. Get to work board designers!

• READs and WRITEs are from 16 to 128 bytes wide.

• 4 link device can have up to 4GB, 8 link can have up to 8GB. (This seems small to me, but I suppose it comes down to storage/bandwidth balancing, and you can have 8 devices on the same link.) Oh, they see the problem too. They are considering using the currently ignored lower order bits of blocks to expand the addressing, and there are two bits reserved just above the address. Quick, someone get the time machine, take them to visit the IDE disk block addressing planners.

• The refresh logic checks ECC and rewrites if a soft error is found. Take that cosmic rays!
Thanks. This is actually great feedback for us.

The distraction-free splash page is designed for first impressions. For return visitors, we make it easy to log in or try JackDB in a couple of clicks. We're always trying out new things with our design.

Our vision for JackDB is building a ubiquitous platform for working with data. Hence, "Make a lasting connection with your data."
Syria Has a Massive Rape Crisis
How is finding the digits of 2^57,885,161 - 1 useful?
"Your margin is my opportunity" - Jeff Bezos
> Just do a full brain scan and store the digital data until the nano-bots arrive?

Because we don't currently have the technology to either scan or store a 3-d scan of your brain in the same resolution you can get by physically perfusing it with antifreeze and dropping it into a bucket of liquid nitrogen.
You can read the backstory of the project on http://weworkweplay.com/blog/deleting-borders/
Gyes, a web aggregation platform for the web
Gyes (pronounced: jaez) is a data aggregation platform for the Web. Gyes allows you to develop, schedule and troubleshoot data extraction programs that translate html content into structured data you can use later on. It also provides an REST Application Program Interface to consume the extracted data.

Gyes uses gannet to build the crawlers. gannet is a JavaScript library designed to run on top of PhantomJS. JSON is the de-facto format to store and retrieve the data.
I'd actually consider starting with one of the latter two. Consider Phlebas is great still, but distinctly less mind blowing than PoG or UoW..
>10K BTC would be worth ~$1.4M and the pizza will still be worth relatively the same as it was before

I can't see how you arrive at this. No-one is going to buy a pizza for 10K BTC anymore, so clearly the worth has changed.
Only off by a couple hundred years, no big deal.
My not particularly well informed understanding is that it is more a of a practical exception than a technical one. So a patent holder could try to use the legal system to stop personal use, it just isn't worth doing.
I tried searching the spec itself (http://hybridmemorycube.org/files/SiteDownloads/HMC_Specific...) but it doesn't seem to contain any specifications about the latency.

Lots of talk about latency-minimization though, but it seems this is basically a packet-oriented interface (with CRC on packets, retries and stuff) so I guess latency will be larger than with today's DDR interfaces.

Perhaps computer systems will have both DDR memory and HMC, letting the OS and/or applications decide how to distribute access for maximum performance.
I met my wife in Haifa. I know where that building is...
I think it is a hard requirement; nobody keeps tight track of $1 coins because it's hard to trade a few million dollars using just that. A cryptographic currency wouldn't have this issue.
I mean, I have gone through Codecademy, Udacity, Lynda, etc. but I still haven't written much of my own code besides some simple if/else scripts.

I usually just plug and play with prebuilt tools like Masonry.js and other jQuery/PHP libraries I find useful. So I'm not sure if that counts as actual programming.

I've always been a designer, and have come a long way on the programming side from where I started. I still have a long way to go, and Treehouse seems like it could be a great tool.
This is interesting - as 3d printers mature, and as home brew drug manufacture improves how the hell will pharma companies be able to enforce this - I mean at some stage soon we can download a recipie for aspirin, why not dimethyl fumarate?

To be honest because the DEA will drive such printers underground, which with 54,000 reasons to go underground is an amazingly bad idea

If you are interested in recreational drug legalisation this is the industry to support - something will change
Safari Still Winning the Mobile Browser War
The central premise for Litecoin using scrypt was that it was not able to be mined on GPUs, this was quickly proved wrong and the statement retracted. There's no technical advancement in LTC, it's just a weaker bitcoin clone.
It's gigabytes, not gigabits.
This is the most truthful and insightful comment on this thread. Thank you.
this looks great. since i switched to postgres from mysql, i was missing something like sequel pro. i tried induction, but it is buggy. will be trying this out shortly!
I've recently started using AeroFS although my invite email was gathering dust in my inbox for a long period of time and it was exactly because I couldn't figure out (in few second) why I should use it.

Well, this is actually a relatively different service compared to Dropbox and plethora of other store-your-files-in-the-cloud types. There is no storing of files in the cloud. However, it does the machine-to-machine sync very fast.