skysight-inc/HackerNews huggingface dataset:
that's also a similar price to other MS drugs (eg beta-interferon).

my understanding is that none of these (existing and new MS drugs) is a 100% applicable fix. they all are effective on only a subset of patients, and they all have different side-effects (which is still good news as it improves the chance that any one patient will find something that works (the subset of affected patients changes with the drug) and is not harmful).

also, fwiw, the govt here in chile pays 80% of the cost. i don't know if that means it can also negotiate a lower price, but i would suspect so.

and does this also suggest help for other auto-immune diseases (lupus etc)?

[update:] also, talking more about the economics - the market is probably very inflexible. existing patients with a drug that "works" (and these only work in some statistical sense - they reduce the chance of outbreaks) is not going to want to switch, because (1) there's a large chance that you'll start having outbreaks again and (2) often they take months to become effective.

so the main pressure in lowering prices has to come from either large purchasers (national health systems, insurers) or from new patients. for new patients i guess that oral delivery (i think?) is a big win over injections. that is something people will pay for.
American websites defaced by Hackers in Palestine support
Ultimate maker board: Arduino + 1GHz ARM for under $60
> Code should be self readable, and if you get
> to the point where it isn’t, then you may have
> to rewrite few bits. This is not always
> possible though, especially for temporary
> hotfixes or hacks. In this case, comments are
> a must.

* Sometimes business decisions may not make
logical sense, but someone says "do it this
way." It makes sense to comment this in the
code.

* The code might tell you what it's doing, but
not necessarily why it's doing it.

* You may be making use of legacy components that
you are unable to rewrite. It may make sense to
comment on their use within newer code that
interfaces with them, making it possible for
people to bugfix the interface without needing
to delve all the way into the legacy component.
Yes, I understand that there are things that you can do. But, as those are in the way of convenience, we can assume that not everyone will take the extra effort to create constantly new wallets, etc.

So, in case someone can trace you to a wallet, that someone can know all your transactions (of course, only the transactions for that wallet), which is a huge potential privacy risk.
blogspam is annoying. We're supposed to submit original sources
whenever possible (according to the HN "Guidelines").

Original hybridmemorycube.org press release:

https://news.ycombinator.com/item?id=5485833

Original computerworld.com article:

https://news.ycombinator.com/item?id=5485823
April 1st, Time: 00:00 - Price 0.82 USD

April 3rd, Now - Price 5.45 USD

http://www.litecoinpool.org/charts

yup, looks legit :)
I believe this one we actually will see pop
Many of the proponents of these currencies believe that a currency governed by mathematics is better than a currency governed by fiat. Since the government can print as many USD as it wants there's no way to fix an exchange range unless the cryptocurrency allows unlimited money supply increase, which clearly has to be controlled by some central authority.
>Hmm...except that cryopreservation is still, as of this point, a complete crock of shit. Trying to find a necromancer would be more productive.

No, that's not very rational. Cryopreservation may have low chances of success, but it's like a billion billion billion times better than just dying (which has zero chance of success). Nobody is claiming that cryopreservation is very probable, but it's a lot better than nothing.

>Now, imagine you are trying to flash freeze an entire body.

I don't think your critique is very relevant, when almost all cryopreservation is only done to the brain, not the whole body.

>Ignoring all the cell death that has been happening for the last hour, how about thawing?

Thawing is not relevant to be discussed at this point, because the bodies will not be thawed using current technology. If the cryopreserved brain has enough information to be reconstructed, it will be done at some point using advanced nanotechnology. Nobody will be thawing brains using 21st century technology.

> I'm not even touching the morals and ethics of companies that are under no obligation to actually do what you paid them to do (since you are dead).

Yes, there are risks. Nobody is claiming that cryopreservation has a very high chance of success. It's a lot better than nothing, though. By the way, thse cryocompanies or organizations tend to be owned and supervised by relatives of the cryopreserved people. These managers also want to get cryopreserved themselves, and want to reconstruct their own relatives. In addition, there's great scientific value of bringing 100 year old people back alive.

By the way, scientists don't refer to the cryopreversation as freezing, they call it vitrification.
You could mention the use of affiliate links in the footer, just in case someone gets snarky.
I'm interested to see if a flurry of crypto-currencies develops into a bubble with all the craziness that could mean. I'm not sure on the defenseability of BitCoin to filtering by ISPs as could perhaps be mandated by the government. If driven underground what would the reaction be?
If it is not mined, who gets the starting coins?
I agree that they are mostly a platform, but they have had at least one game come out every year (except 2002) since it started.

Recent ones:
Portal 2 - 2011;
Counter-Strike: Global Offensive - 2012;
Dota 2 (to be released) - 2013
There is a coin worth $1 USD that doesn't require mining and can be exchanged anonymously. Is the cryptographic aspect a hard requirement?

http://en.wikipedia.org/wiki/Dollar_coin_(United_States)
A look at C++14 and beyond: Part 3
Most people can't save. The poorer you are the more expensive things get. Food costs have doubled. So has fuel, which in turn increases utilities. They barely scrape by.
I'll make a qualified concur with you. Order by and group by are often best lest to the database, where (proper) indexing can provide streamed access to large sets of data. Relatively static lookup value substitution and security checks (via permissions/user tables) are best moved closer to the user.

I'm also a big fan of building transactional updates in "service-space" and using transactional coordination to ensure ACID, rather than making bulky stored procedures to churn over bits of procedural data.
The Surest Way To Build A Billion Dollar Consumer Web Company
So, it was not seen as an achievement at all!

I don't get that interpretation from that quote at all. To me, the quote is about contrasting the speaker's subjective view with a more objective "standard" requirement for a PhD degree. It's basically saying: "To me, his work as that of a genius. But YMMV. However, even if you don't want to go quite that far, you'll certainly admit that it's great and fulfills the requirements for a PhD."

Not being the work of a genius does not necessarily mean that it's not an achievement.
I think that's meant to mean "press release text", but my first thought was definitely "public relations text".
Unless you add a license of some sorts stating that it is illegal to exchange it for real currencies.

Then someone will do it regardless, but at least they will be prosecutable.
+1 Neat!
Lots of great templates.
Can I point AeroFS at the root of my NAS and have it back up everything (including permissions and userid/groupid metadata) to another physical location?
Well, the Kinect should give 3D data, so that should help, right? :)
The problem is you need to transfer data out to use CUDA. I'm assuming with HMC the CPU can access data with promised 320GB/s speed?
Does Your Marketing Team Work Remotely? Here’s How To Make It Work
War for the Web documentary: US Consumers v. Big Providers
I must say I had never heard of this before and it looks like one of those "too good to be true" things. I'll believe it when it's a consumer product.
Invest it in real estate. Buy a 4 family house, and that should give you enough income to survive, and work on whatever you wish.
It took me a few clicks to figure out what JackDB is.

With all the new datastores out there, ending your project with DB seems to imply it's yet another database, then you go to your homepage and I have to click the about button to even figure out what the product might be.

Also, I kind of hate the tagline "make a lasting connection with your data". Given that your homepage only shows that and 2 buttons, it seems that you really want me to "make a lasting connection with my data" more than figure out what your product is. Why would someone even click the "Try JackDB Now" button if they don't know what it is or does?

http://www.jackdb.com/home.html is a much better page and maybe it should be your hope page. It certainly explains your product better.

On a side note, I'm not sure that there is a market willing to pay $12 or $29 a month for a web based database client, but I can see the basic appeal. Best of luck!
The only passwords it makes any sense to ban are the fifty or so most common, plus simple number and case permutations of these, and MAYBE the most basic leet-speak versions as well. That's enough to make a prankster typing at a keyboard give up, and that's as much as you can hope to stop with this type of policy. No password ban will stop someone with a cracking app, and no serious intruder will be without one of those.
In fact I would wager a guess that's the whole idea for them. Kind of a variant of "Peace by way of superior Firepower".
Show HN: A simple online app for your sprint planning meetings
But what's the latency? I'm inclined to mention that a truck full of tapes hurtling down a freeway has a 'high bandwidth'.
Kito Corp - Barnes & Noble Plans Buyout.
The web part of any device is at the mercy of the world, but apps are patrolled for that stuff and Etoys would be an app.
What do you think about having two links side-by-side (affiliate and non-affiliate)? Or having a global swith to turn on/off affiliated links?
Gaining Even a Little Weight Greatly Increases the Risk of Heart Disease
Regular exercise and healthy eating won’t only shrink your waistline; it can also shrink your risk of coronary heart disease (CHD), according to an article published in BioMed Central’s open access journal BMC Medicine. In fact, research from the Million Women Study shows that even a small increase in weight can put you at a risk of CHD equivalent to the risk associated with getting older.
$150/mo for insurance for a family is super low unless your company has really good benefits. If you're working at a startup, you're more likely to be putting in $800/mo on top of the employer's contribution.
Spanish Linux Group Takes Windows 8 Secure Boot to the EC
What utter BS of a guide. As a musician for many years, I can tell you that he would not have a number 1 hit if he didn't have hundreds of thousands of YouTube subscribers. If this guy didn't have the YouTube subscribers, he would of sold to his family and friends and that's probably it.

The music industry is a popularity contest. Believe it or not, there are hundreds of thousands of artists who produce high quality songs but don't have a huge fan base preexisting on a social network.

Getting a big hit is the same as getting a big hit in the startup world. Unless you have a prexisting connection/PR marketing presence, the success is mostly driven by luck and brutal hard work.

What grinds my gears in the music world (and startup world) is when people who have success think it has something to do with their product/song being more unique or better than the next guys. 9 out of 10 times it is due to some competitive advantage the artist/founder had over others.
That's 250 GigaBit/s, this is 320 GigaByte/s. No?
My main thought is that it doesn't really matter if its filtered by ISPs, or if it's impossible to shut it down because they can't stop the hackers, man...

If the government of the US decides it's illegal and declares businesses and individuals accepting BTC to be trading illegally, then the value will undergo a significant collapse as it's now no longer the way of the future but just a secret internet thing (in the US). If a few other countries follow along then all dreams of BTC as the new global internet currency and transfer medium fail.

Bitcoin may not be the easiest thing to shut down due to its P2P nature, but that doesn't mean it can't be effectively destroyed by people in power.
Has anyone actually seen the source code for edx? They claimed that they would release it. I don't see a repository on Github or anywhere else.
Awesome; plus I love the template thumbnail is a link to the bundle's preview thumbnail. Always updated on commit!
> ... is not so large that the original brain can't be reconstructed either by scanning it while still frozen or by repairing it with nano-bots.

You might as well argue that nano-bots will be able to reanimate a body that has decomposed, and save money on all the freezing equipment. Perhaps that will be the case if given enough time, but we seem to be a long way away from that technology.

The business model seems to be "give us money now, and the technology that could make this work will probably be invented soon enough. Probably".
>Javascript is not up to performing all the tasks that it should be able to do if it wishes to be a comprehensive platform.

Like what?
I always feel that such glib attempts at one-upmanship are a good indication of immaturity.

Or perhaps you don't get involved in producing anything with non-trivial functionality? Because anything simple enough not to need instruction is probably too trivial to be worth using.

There is nothing intuitive in life except fear of heights and (possibly) the location of your mother's milk, all else is learnt.
NASA Paper: Nuclear Power Prevented 1.84 Million Deaths
A new study out of NASA’s Goddard Institute for Space Studies says the use of nuclear power has prevented many more deaths than it has caused because of its lower impact on the environment.
Security updates for all cPanel & WHM versions released
Engineering, atleast in Canada, is similar.

You can write a series of tests instead of getting a university degree. Though you still need to do the 4 year engineer in training before you become a PEng.
$1.4M, not $140M.
For the first 3 I agree with you, but I feel the later Culture novels expect a certain level of familiarity with the Culture universe
Professional iOS 6.1.3 Unlock iPhone 5 For Life Guide
They don't!

If someone could freeze at least a small insect brain after it "learned something", unfreeze it and prove that it retained what it learned, I might have at least a grain of faith in this. Even getting an insect ganglia out on a feeder plate with electrodes, training it to respond in a way to a certain sequence of input electrical impulses and proving that after thawing and reanimation it still preserves that memory would light a spark of faith, but we don't even have this!

Understanding "biology 101" means understanding that biology is about experiments, everyth is empirical (and will be for quite some time I guess), nothing can be said that "it works" in biology or medicine until you experimentally prove it does. Maybe in a few centuries we'll have cool equations describing life and have something like "theoretical biology" that will be like theoretical physics is to physics (no, what we call "theoretical biology" nowadays is not that!). Show me some equations (derived from experiments, of course, and that can predict other experiments of course) describing the amount of information relevant to a human's personality that can be recovered from a frozen brain! If you can't, prove it experimentally. If you can't... bad luck! With the kinds of probabilities involved in biology, "good things" (like being lucky to be able to revive a frozen human brain) don't happen by chance!

"Nature"/"The universe"/"God" is NOT on our side on this path, so there's no room for optimistic thinking, we can only rely on cold (literally) hard science and math!
If you're wrong, what good is conviction? I'd think that's even more dangerous. It's easy to call out the cynics who misappropriate and obfuscate words for their own gain. It's scarier when people earnestly see nothing wrong with anything open being "a Linux."

Morozov bemoaned the overuse of "open." Now we take that a step further. Anything that meets the already-loose standards for being "open" can also be "a Linux." Is there any workable standard with which to limit this indulgence? Hopefully it's somewhere between a "Twilio for photos" and a realtor holding a "Linux house" for prospective home buyers.
Nobody is allowed to see my code. It's not allowed.
Most interesting (to me at least) is "Proposing the Rule of Five"[1], so that no copy function, move function, or destructor will be compiler-generated if any of these functions is user-provided.

[1] - http://www.open-std.org/JTC1/SC22/WG21/docs/papers/2013/n357...
The JOBS Act: Follow-up on FundersClub
Is there a crypto coin where the mining work isn't a useless waste of energy?

Bitcoin mining (and maybe litecoin, dunno) doesn't do anything useful in the process of using all those hardware and electrical resources. No protein folding, no SETI, no looking for mersenne primes - just a bunch of crypto work that gets you bitcoins. It'd be nice if you actually had to produce some knowledge to get the coins.
Homesick is a free horror game. Its developer is dying and is seeking donations
You are entitled to voice your opinion, but…

10K BTC would be worth ~$1.4M and the pizza will still be worth relatively the same as it was before. Unless $GS and friends are actively long pizza futures (since it is a vegetable now), then it might be a little more expensive than it was before.

People seem to be focusing too much on market cap and not on the ever increasing companies and people using it to transact for services.

Dont hear much talk on here about EURUSD, USDJPY, USDCNH ctrl+P operations, i wonder how healthy that is?
Depends really. If they're getting fat off my economic output then that bothers me. If, by my participation in the BTC economy, my economic activity fuels a rise in the price of the coin, then the early adopters are effectively profiting from my actions. This bothers me.
Since when do they have to be a lifestyle company? Hire a CEO with mandate to grow the company, and go start the next one...
Interesting comment from the article's comment thread, from Janne. A patent is for the commercialization of an idea. Anyone is free to implement any patent for personal use, as long as you don't sell it. If the use of this common chemical, and its transformation, is understood well enough for this to become a home brew possibility, then people could do exactly that. Not that this is possible or advisable for most drugs, but this particular drug may be one.
[Show HN]Gutsy, a quick script to parse Who's Hiring for internships
Comparison between Bitcoin and Litecoin: https://github.com/litecoin-project/litecoin/wiki/Comparison...
In 1980, four of us - myself and three co-workers, attempted to write a pac-man like game. I really haven't had much interest in game programming, but one guy did and wrote a basic display with keyboard moves. The ghosts were in the form of each of our initials, and the plan was each of us would program our own ghost strategy algorithms. It never got too far along. I should also mention that this was written in Pascal for the Texas Instruments 990 (not the POS 99/4a home computer) business computer on 80x24 monocolor text-only screens. Hey, but it was multitasking and multiuser - each of us could be playing our own copy of the game. My Windows 7 PC still gives regular demonstrations of its non-multitasking DOS heritage. In 1982 I bought an Apple II Plus thinking I might develop some games... coming from a mainframe and minicomputer environment, I was more than a little disappointed. I didn't return to PC programming or even own a PC until 1988 when I found out SCO Xenix would run on a 286... for weeks at a time, with multiple users, without crashing. Gaming has come a long way, but some OS fundamentals still haven't, at least not in the PC world.
TurboSMTP's new dashboard comes with advanced stats & tools
Creating A Viral Slideshare: What I Learned
The rate of Bitcoin production drops in half every few years. It's a jagged curve designed to end-up producing a fixed number of bit-coins.
15 Iconic People Who Changed Internet
The source will be released in full on June 1st with various components being released earlier.
so in other words, a prettier looking phpMyAdmin
The Linux CLI is an IDE. I do not need another...
I've particiapted in the litecoin trading for about 3 days now and the price development so far has been unreal. what's notable is that whenever I take a look at the orders book buyers outweigh sellers by a ratio of at least 2:1. Currently there are open buy orders for 154724 LTC (that is >850'982$, as of 3/4/13 - 15:41 CET). I'm currently gambling on mtgox supporting litecoin on its exchange.
It's a bit more surreal when it's general knowledge what to do with the hammer but you have to license your placement-of-hammer IP.
Ruby (and Rails) is as relevant as ever. The hype about it has died down, just like the hype of Java was dying when Ruby was becoming the Next Big Thing. Is Java still relevant today? (Yes) The hype around the technologies of today (Objective-C, Node.js) will die in a few years as well, it is unlikely that these languages will become irrelevant.

One of the great things about Rails these days is that many of the startups that were founded during the hype period of Ruby are now established companies: Twitter, Shopify, Groupon, Github, LivingSocial, Zendesk. If startups are not your thing, these are just a few examples of many larger companies looking (desperately) for people with Ruby on Rails talent.
> As I understand it, in Bitcoin the difficulty goes up so that the rate at which new coins are mined stays pretty much the same.

The rate halves every so often, the creation of new bitcoins slows over time, to the limit of 21 million.

The limit is imposed by choice, if you kept creation proportional to some factor of the network rather than ever-decreasing and with a solid cap, you could change the game.

I agree that processing power is not necessarily the best factor to relate it to.
Watch out, if it gains traction, it will be gamed.
Yeah, just mention the affiliate links at the bottom of the page and have a little link "Click here to remove" and have it run some javascript to change the links.
I think if you read the post a different way, what you will find is that the writer had an emotional connection to success and to doing something interesting, and I think he valued that more than the money he got, because as he said, his boss was dropping 50 thousand dollar checks on his desk while he was coding something.

You can see it when he speaks about the media companies paying attention and trying out all his ideas, both of those are measures of respect and acknowledgment that his/their ideas were useful and a positive contribution to society.

If anything, I read this as a warning that "life isn't just about stacking bills" and that money is a means to accomplishing the goals you set before yourself. If you short circuit the fun you are having for money, you either will find something else that makes you happy, or you will pine for the meaning in your life that you lost, and write this article.
Just put in the affiliate code. You are already advertising for Amazon, so you might as well get the commission.
Careful with copying the livery of hackernews as it may contribute to a successful claim for passing off or similar trademark-y infringement claims.
That's interesting! I wonder if a charitable company decide to make say AIDS drugs and give them away without breaching patent law?