skysight-inc/HackerNews huggingface dataset:
How do you definitively test for depression?

Are the diagnostic methods pretty good? Both accurate and precise with very low false positive rates?

Is the medication proven to work for depression?

Sorry but I think a lot of that can be argued that we are still shooting in the dark. I want a test for depression like I test for strep throat. AND I want the "cure" to be repeatable.

Yes we are still in the dark ages.
On every parametric cultural ontology I've seen the U.S. comes out at the top for individualism, e.g. Hoftstede's IDV: {US, 91; China, 20} [1]. This is why we believe in free speech, even if it's hateful speech, to a level alarming to the rest of the world. As Americans we are likely to see society as a composition of individuals than a cohesive system, or of individuals as points on the fabric of society.

[1] http://geert-hofstede.com/united-states.html
Depression has different stages. Sometimes it's easy to get out of depression. I'm sure we all experience it at our "low" points during different stages of our lives. From failing a startup or death of a family member.

The depression that we can't get out of alone -- when we lose all hope for everyone -- that's the hardest to fight. Losing your will to live can quickly lead to suicide. And it's hard to tell from someone else's perspective that you're suicidal because you've pushed everyone away.

I think the only cure to the second form of depression is to practice a healthy state of mind everyday. Enjoy life and friends that are close to someone. Always share your problems with a close person (someone you truly trust). You must have the will to live. Giving up isn't the answer to all your problems because someone else will have to inherit your problems. Which isn't fair for that someone!
Interesting idea but difficult to implement. The hackers hide behind proxies. Unless you could cut off proxies everywhere they would still find ways to get in.
He's not completely off. Psychology is still in its infancy. That's putting it lightly.
Wonderful wonderful article. Is there somewhere I could pre-order the book (which would be the first time that I have ever done so).
Yep, I was hired by a company where I did an internship and was actually paid slightly less as a full-time employee than as an intern (more benefits, though). As an intern I made $40/hr, hired full-time at $80k/yr.
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Seems like putting a password on their printer and thermostat as well as telling their employees not to click random links or better yet setting up a security rule on their email router to not allow links and attachments from outside the network would have prevented this.

In essence these big companies are leaving the door unlocked and keep acting surprised when people that don't like them open it up and poke around inside. There needs to be more education and common sense this sounds like a very easy attack to prevent.
But if you talk language, Java has never held a candle to C#.

The original C# language and virtual machine was inspired by Java.

Then, C# got:
* Better generics

* lambda expressions

* the yield keyword and compiler magic for iterators

* explicit interface implementation (rarely needed, but very well thought-out for when you need it)

* LINQ!!!

* Type inference

* Dynamic keyword

(I'm forgetting some things, it's late).

Anders has guided the C# language brilliantly ... Java has been outpaced at every step of the way. So many somewhat radical features have been added to C#, and from my standpoint, every single one of them was very well-done.
There is a new skillset called "Interview Engineering". 4 years of computersciece/ real world experience may not get you a job but a month long "Interview Engineering" research will crack a process like this.

Good Engineers/Tech leaders develop an intuition for things based on products, programming, process and people. Most of the time coming up with a good interview plan for a particular team makes a lot of sense. Not everyone who reads this blog should interview. Interviewing needs a level of maturity as an engineer.
A test can't be done in a lab on bloods but most of the time you can usually see the signs simply by observation and just talking to the person.

I say the real problem is that it's hard to treat.

When you see a close family member or friend suffering, you can't force them to go the doctors, where depression would certainly be diagnosed, and many often just don't go.

The standard set of medication for depression usually takes a couple of weeks to kick in. It's common to see symptoms worsen before they get better during this timeframe. It's gut wrenching to watch if you have personal experience with it.

Effective therapies require effort from the sufferer. If you're feeling really low, it's hard to the put the effort into anything - drops in personal hygiene standards are not rare.

It sucks we don't have a test for it like we have for physical disease but I think a bigger problem is treatment, which is done in a "see what works" manner if the first line of defence doesn't work, which is really damaging when you consider the above.
I think he's arguing for what you want. Strong, general programming skills paired with intelligence and productivity. If you're new to Joel's blog, he's brilliant and worth reading (and by this point an old-hat at giving advice on running companies better).
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Grief is normal. Grief is an appropriate reaction to a lifetime event. Grief normally subsides after a time; it's still there, but not overwhelming.

Depression is not normal. When you still feel overwhelming grief years after the event, and it's affecting your everyday life and preventing you from functioning, then it's depression.

> I think the only cure to the second form of depression is to practice a healthy state of mind everyday.

I sort of agree - mindfulness and CBT techniques can be used everyday to help prevent depressive thinking.
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And what I'm getting at is the fact that there SHOULD be a blood test. Or a biopsy. Or something more concrete.

Is it not possible? I'd like scientific research to say that it is impossible.
Ask HN: How do you get someone away from affiliate marketing?
My dad's a long time hacker, but recently fell into this trap of get rich quick affiliate marketing.

My philosophy has always been to help people and do what you love. I emphasize offering real value to people, and I know everyone on HN tries to do the same. Basically scamming people and using immoral techniques to sell some useless product is something I want absolutely nothing to do with. It feels almost impossible to get through to someone once they're hooked.

Any advice?
My go-to editor is http://jsonviewer.stack.hu/
BB10 is nothing like the older platforms, which kinda sucked. You couldn't even run code on a test device without getting it signed by RIM, and the service crashed frequently.
http://hashfold.com/techfold/amazing-web-page-architecture-m...
Always wake up at the same time (WE included), go to bed as soon as feeling tired : give marks to, and listen to your own body.
The problem is that YAML is used by Rails & Co as a parser for untrusted user-provided data. It does not matter if there is buggy implementation in Python/Perl if nobody use them.

If other framework were using YAML in this fashion, yesterday will be the time to look for security holes in those implementations.
A bit off topic, but are you sure Excel was the right tool for communicating with instruments, power point for simulating instrument front panel etc?
I think LabVIEW or any other appropriate tool with Excel used for data presentation would have been better.
What I'm saying is a clear cut test would be great but it's not actually hard twit out it and a bigger problem is the treatment.

I think the answer to both lies in the same area though, since the source of depression is not clear in the brain (I believe there was a study that shown SSRIs have an immediate effect on serotonin re-uptake yet takes a number of weeks to ease depression - implying serotonin doesn't play such a direct role as once believed).
He isn't talking about medication, he is talking about CBT. CBT on it's own has been shown to be effective for low to moderate depression.
Definitely UNIX interop, at least at the tooling level:

> MSYS is a collection of GNU utilities such as bash, make, gawk and grep to allow building of applications and programs which depend on traditionally UNIX tools to be present.

[0]: http://www.mingw.org/wiki/MSYS
With the Web version going to have an update every 3 months, I think setting up the foundation would have been higher priority. The improvements will keep coming in I hope.
Thank you, Mark, for writing this.

I have lost three close friends in the past three months to depression. Their deaths were so similar it was shocking; they were all among the most brilliant people I had known, and all had been suffering from depression almost their entire lives.

At the funeral of the one who was closest to me, another girl told a story of how on one day when his depression was particularly bad, he boasted in his great success for the day: Getting out of bed to brush his teeth.

Bear in mind this was a kid who spoke Russian and Arabic fluently, who loved the arts, was incredible at chess, was a great musician, and took Calculus BC in 9th grade. Absolutely brilliant. He was a fighter, he was stubborn, he was young, and some say he took his own life. I prefer to say that depression took his life.

Sorry for getting so personal, but I simply can't take any of the comments that say "just get over it." Depression is as real and as disabling as being paralyzed; it may not happen to everyone, but to say things like, "You need to be stronger" are no more appropriate to the depressed than they are to the paralyzed.

But most of all, if any of you are reading this who have depression, keep fighting. Recognize your brain lies to you, and no matter what it says there are many people who love you and it will get better.
...except the GP provided no rational state objective for this except insinuating general malevolence as perceived by the Chinese government. That's my whole point. There's no argument here except equivocation.

> This may not be a news flash for Israelis or Americans, but I bet it would make for informed reading for an Iranian (or even for an American sitting next to an Iranian). I've found foreign articles on current events illuminating of my own cultural blinders.

Sure, but Stuxnet was built for very specific purposes, and sponsorship of suicide bombers is so far down the list of motives that it becomes essentially a non sequitur. However, it does achieve very well a change in conversation from the implications of introducing a computer worm to sabotage a nuclear program to a discussion of how evil a regime is. The former is a conversation worth having, no matter how much you feel Stuxnet was justified.

Here, we have a comment about the "context" of this action, which is summed up for us pretty well above as "they see this as a skirmish in the larger campaign to discredit the PRC's current leaders, foment discontent, overthrow the government, and set up a (US-controlled) democracy" (which, incidentally, sounds exactly like the greater context for the great firewall and state-controlled media, as well). This completely ignores the very specific correlation the Times points out with a series of articles they ran on Premier Wen Jiabao. That accusation is much more specific then the "context" found above.
Off topic, but 'nafta' means petroleum in a good deal of languages, e.g. http://ru.wikipedia.org/wiki/%D0%9D%D0%B5%D1%84%D1%82%D1%8C
Thanks, Slate, for regurgitating what you heard a friend mention in a coffee shop and looking on Google Finance for a few numbers to fill in.

The first lines from the Argus report show:

"...management's emphasis on keeping prices low and heavy infrastructure investments...Most of the weakness appears to be in the International division, as the company expands operations in economically weak markets such as Europe and China."

(If you want to read Argus reports, many stock trading sites will give you free access after opening an account.)

Edit: not sure why I'm being downvoted; afterall, I'm responding to an Article which has this line: "That's because Amazon, as best I can tell, is a charitable organization being run by elements of the investment community for the benefit of consumers"
My Nexus has a ringtone (called radiation) that emulates this then segues into a little tune.
Because porn sites have little benefit by being seen by users subject to such filters, and they'll be less targeted if they keep to an area that is simple to filter out. The whole concept of the evil pornographer trying to corrupt your children is deeply weakened by a recognition that some people want to filter out porn, that that's OK, and that the industry should make reasonable accommodations for that.

Those with disposable income to spend either on porn directly or at the porn sites' sponsors are perfectly capable of browsing on their home connection where no restrictions exist. The only people who are filtered are a) children, who don't have any money to spend on things like that, and ostensibly are not legally allowed to consume/purchase "adult" material anyway or b) people who are at work. Neither of these types of people are worthwhile to the porn industry.

I think it's even positive for citizens with national web filtering, because it will take pressure off moderation of other TLD, and their typical national web filter circumvention method will allow access to .xxx just like it allows access to all the other banned stuff.

It also allows people who want to filter for porn to find it easily. Think imgur.xxx for NSFW and imgur.com for not-NSFW. imgur guy says he is obligated to keep "no pornography" in his TOS even though it's obviously not enforced because otherwise he can't get any advertisers. A segregation like this can allow him to actually follow these terms and take adult-specific advertisers on the site in the xxx namespace.

The only argument against the segregation into a custom namespace is that porn sites shouldn't make filtration easy, but I don't really see any benefit to that position for anyone.
Maybe but more likely one faction thinks another has leaked info and wants to get evidence. The power struggles over succession to the leadership are very serious. Indeed the whole business of staying in power is serious eg current case of poisoning.
Steve Jobs and Larry Ellison both publicly attribute(d) their success in part to psychedelics, so "some feel" is probably understating the case.
Sign-on email verification:  is the email address a disposable email address
Ist there a way to avoid maintaining local blacklist with domains from such providers?
> clicking each time

once, in the navbar, and whitelist the business-required site.
Dictators... Are you saying wen jiaobao is a dictator?

Given the vast improvement in the way of life for Chinese since deng xiaoping, and their continuos prosperity. Are we really sure that's the "best" thing to do.
Here's a great guide to coming off of psychiatric drugs — http://theicarusproject.net/HarmReductionGuideComingOffPsych...

Good luck!
I like it too. Thanks for sharing. :)
Underpowered? I suppose it doesn't have a static type system. You can do OO just fine in Javascript, though.
In India, where there is a large network of family and friends that you can tap into and confide in, it's much easier to pass through your low periods without them having a lasting influence on your psyche. Traditionally, there were no psychiatrists in India, but lots of gurus and so called healers that were probably used by those staggering in life. Today, the family and friends network is being replaced by Facebook which is a lot less substantial. Also, western medicine style psychiatrists are now quite common in all cities. The incidence of what is now called mental illness is picking up in India.
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Companies investing in themselves? Disgusting behavior.
We have to study it from multiple angles. I don't have a problem with more research into SSRIs. Hell I don't even have a problem with SSRIs.

The main issue I have is that people think our understanding of mental illness / psychiatry is as good as say pathology.
Would that hold up in court? Anyway, I would just saturate the VPN.
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Depression can be diagnosed pretty easily by running through a form of questions and checking off checkboxes. You are depressed if some statistical measures score above a certain value.

To which degree are you...Sad? Have trouble getting things done? Don't find joy in the things that used to make you happy? Thinking about death? Feel any emotions at all? Afraid that something terrible is about to happen? Thinking about killing yourself? Planning to kill yourself? Etc.

It's not an exact science the way physics is, but we are only in the dark ages of mental illness in the sense that a lot of uninformed people don't have any idea how these illnesses are treated by professionals.
I lived in India and the conditions could be described to be bleak enough to make the most optimistic person sad. Suicide rates there were 10x what they are in the west. I am not even sure there is enough cultural understanding and sensitivity about depression: There used to be an uproar and attempts to treat the symptoms when high school kids used to commit suicide by the dozen (typically after poor exam results).

(To the other poster, depression is not the same as "being sad" and having a bunch of people around you all the time asking you whether there is something wrong is not necessarily conducive to mental health. (Just to offer a flip side to your oh, there is so much community which is why there is a lack of mental illness anecdote.))
Just to give some numbers to this, for anyone wondering:

In 2012, Amazon made $631 million profit on over $48 billion revenue - meaning they converted a little over 1% into profit. Meanwhile, almost every other comparable company had close to 20x that. Google made about $11 billion on $48 billion, and Apple made $41 billion on $156 billion. From a purely financial perspective, it really is insane.
Right, that's exactly the other citation I needed.

I think that explains why the US is so hostile to the activities of china (and vice versa)
I always enjoy finding a good rant or otherwise "unprofessional" comment when I'm going through code. It's like a little inside joke that somebody left for you. A little profanity doesn't bother me as long as its funny!

I've had people tell me that they ran into a comment of mine many years after the fact and what a great laugh they got from it. Easily 99.9% of my comments are totally boring but once in a while you run into a situation where it's appropriate to vent a little.
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URL: data:text/html, <html><head><script>function placeCaretAtEnd(el) { el.focus(); if (typeof window.getSelection != "undefined" && typeof document.createRange != "undefined") { var range = document.createRange(); range.selectNodeContents(el); range.collapse(false); var sel = window.getSelection(); sel.removeAllRanges(); sel.addRange(range); } else if (typeof document.body.createTextRange != "undefined") { var textRange = document.body.createTextRange(); textRange.moveToElementText(el); textRange.collapse(false); textRange.select(); } }</script><style> html{background-color:#CCCCCC;font-family: Monaco, Consolas, "Lucida Console", monospace;font-size:14px;color:#424242;line-height:1.4;max-width:60rem;margin:0 auto;}body{background-color:#F0F1F1;padding:100px;}</style></head><body contenteditable autofocus onload="placeCaretAtEnd(window.document.body);">we%20did%20this&nbsp;</body></html>

it uses the "paper" look and feed and sets the focus to the end of the document so that you can just continue writing
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As far as I can tell, the advantage of using tormail (the hidden service) coupled with GPG/PGP is simply the added layer of security (which is anonymity). Like I stated before, Tor isn't necessarily for privacy. It is all about anonymity. So if a person doesn't encrypt their messages there is a (slight?) chance of their messages being read. This could lead to compromising your anonymity and privacy.

With GPG/PGP encrypted messages, you will not have this problem as much.

If a person is only seeking privacy then GPG/PGP is more than enough to secure their messages (while keeping in mind the headers are visible - just alter it).

It think tormail is great for journalists etc. who need anonymity to protect themselves from dangerous times. That's about the only thing I would use it for.
English is not my primary languages and especially english maths are hard for me to grasp. That's why i am asking you to demonstrate, using the actual numbers for Ruby and Perl, what calculations should be performed to gain the numbers your site is showing.

Also, in addition, after reading your link, the situation seems even worse. Using the median Perl outperforms Ruby by ~15%, but the main site does not reflect that at all.
You're implying that anything sold through affiliate marketing is a "useless product", marketed using "immortal techniques", and, in short, a "scam".

If he really likes it so much, and it's making him money, perhaps you could convince him to sell honest products using honest techniques?
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I don't quite get what you're trying to say. What "community social norms"? Are you talking about how rubygems.org handled this vulnerability from the beginning? How the community handled this incident after it happened?

And what does it have to do with my quote? I was just pointing out that in general I'm for PoC to highlight security issues when the vendor doesn't respond, but stealing database.yml makes you nothing more than a simple crook.
On the contrary my dear igouy, specialisation can be key and knowing which tool in my toolset is best for different tasks is indeed insightful & helpful ;-)

re: contribute - Looking on my hard disk I see that I downloaded the bencher/shootout-scm back on 1st Jan 2010. However IIRC the process of contributing code back was a bit unwieldy. If some free tuits come my way then I may relook at it.
Are the diagnostic methods pretty good? Both accurate and precise with very low false positive rates?

Yes: "Overall sensitivity was 84% (95% CI, 79% to 89%); overall specificity was 72% (CI, 67% to 77%)" (http://www.ncbi.nlm.nih.gov/pubmed/7755226)

Is the medication proven to work for depression?

There's no such thing as proof in science. A recent meta-analysis: "Most patients treated with serotonergic antidepressants showed a clinical trajectory over time that is superior to that of placebo-treated patients. However, some patients receiving these medications did more poorly than patients receiving placebo. These data highlight the importance of ongoing monitoring of medication risks and benefits during serotonergic antidepressant treatment" (http://archpsyc.jamanetwork.com/article.aspx?articleid=11074...)
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