skysight-inc/HackerNews huggingface dataset:
HIV, being a retrovirus, acts by inserting its genome into the infected cell's nuclear DNA. The infected cell is unable to distinguish it from its own 'native' DNA. This is a fundamental aspect of how the cellular machinery is hijacked by the virus to replicate itself.

Now, nearly a tenth of the human genome is made up of retroviruses (ERVs) that got inserted into our genome over the course of our species' (rather short) evolutionary history [0]. These ERVs were rendered dormant by genomic silencing of entire swaths of the genome (by mechanisms too detailed to go into here) turning them into 'harmless', silent blocks of genetic code we now carry in every cell!

is it reasonable to assume that it would be possible to infect enough T-cells with the virus to overlap a significant portion of the HIV infected cells?

That is the basic assumption, but is not guaranteed to happen. Specifically because a sub-population of infected T-cells, called the 'reservoir' population, are 'sleeping' in the bone marrow or the brain (and numerous other organs), waiting for signals from the immune system to activate them into action, which may happen due to an unrelated infection (or other reasons). This sub-population of cells, once called into action, will start running their usual gene expression program, resulting in the production of new viruses and infection of new cells. This is the NP-hard problem of HIV therapies!

Or is the goal to try to introduce entire modified HIV genomes into cells and then have those be fortuitously replicated and bound into HIV particles which will hopefully go out and re-infect other T-cells and in the process inhibit the HIV production rate?

In a word, yes. But there are too many moving parts to have the whole shebang fly off the handle and cause unintended or unexpected actions. Gene therapy, in its current form, has its place in the pantheon of medicine, but HIV is probably not a very good problem to attack with this approach, partly for reasons I mentioned above. The future of gene therapy holds the definite promises of miracle cures, which will be possible after more research and development (but only made possible by your tax dollars) ...

[0] http://en.wikipedia.org/wiki/Endogenous_retrovirus
A skeuomorph is a physical ornament or design on an object copied from a form of the object when made from another material or by other techniques. [1]

In the case of iCal, it is skeuomorphic, just poorly executed. It mimics the appearance of the object, just don't interact like the real one. In this particular case, we can argue it's bad design, because it's not honest: it deceives the user and breaks the mental model.

I suppose Apple's heavy use of skeumorphisms is less for usability, and more a result of a culture of design inside the company. They often use it to pay hommage to iconic product designs, like Braun products, the Rolodex, Swiss clocks, etc.

[1] http://en.wikipedia.org/wiki/Skeuomorph
I preferred when we called it "deliciousness". A quick search shows that very few people seem to have made the connection: http://news.ycombinator.com/item?id=4628588 http://www.quora.com/James-Wang-5/answers/Skeuomorphism
Tons of people have learned to program with Java. Might not be as elegant as other languages but the fundamentals are the same.
Suicide is a good choice, but trial wasn't because you might get a 10 year sentence. Pray tell, what prevents suicide during trial or after conviction?

Suicide can be an option without depression, but when you have the fire at your toes and it's either death in 30 seconds by fire or in 5 minutes by free fall (and even then it's arguable.)

It's certainly NOT a viable option when you are months or years away of the feared problems, and even LESS so when they are not life or death.

Suicide can be talked about but not like you stated it: "He had no choice, yeah, suicide made sense." Especially when you are not being realistic, you are blinded by a weird combination of prescience and intimate knowledge of the happenings inside of prisons.

Which leads to my final point (this is what led me to answer your nonsense for a final time): Going to jail IS an option, an option that millions go through every year. Some of them are rich white kids that continue their lives afterward. And I can tell for a fact not all of them are raped.
Or at least Scala...
Oddly enough Stripe won't accept that as a test number.
Not sure that showing them security vulnerabilities in the JVM is going to do much good if they are still in the learning phase.
Anyone thought of the benefits to Glee doing their cover? Sales coming the way of the artist. Lots of sales.

It might be a rip off, but the artist will get paid by it being a song to download in the coming weeks.
agreed. me either.

I've had legit installed for months. Only command I ever use is "switch."

I don't trust anything else.
I don't think donating Killing Kennedy or Killing Lincoln to "honor" Aaron Swartz would be very appropriate...
I've always liked the way this is described on his YC bio page (http://ycombinator.com/people.html):

In 1988 his discovery of buffer overflow first brought the Internet to the attention of the general public.
That's certainly possible, but given that Massachusetts has a pretty deep bench of ambitious democrats, it's hard not to see how this is anything but a handicap.

There's something to the law-and-order point, but that would be more true in a general election, which I don't see her reaching.
There are plenty of places in the world where the local coffee shop outputs far better coffee than a Starbucks. I've tried a couple of forms of home expresso, and I can't approach the flavour of the coffee shops around where I live.
Sure, I can make a better coffee than a Starbucks, but thats not what im competing against for my $4.
This makes for an easier comparison.

https://soundcloud.com/suudo/joco-vs-glee-baby-got-back
The “whatever design” manifesto
>At this point, I freaked out. I was worried that I'd done damage to my brain.

That freakout, and that worry (which you apparently have since discovered was unfounded, I hope :) is precisely what the meditation helps you deal with, among other things.

And yes, it kind of sucks that the teachers can't speak more at liberty with you. But there's a lesson there too: in the end, the answer to any trouble you might have is to simply find the craving and the aversion. Find the ignorance in your misery. You were safe and taken care of, and you felt you were at risk. You were wrong.

Blaise Pascal famously claimed that all of man's problems stems from the inability to sit quietly in a room, alone. And we are not able to do it, either. Vipassanna is the rather upsetting path toward learning to be able to sit quietly in a room, alone. And it's very simple, but not at all easy.
IIRC parodies are generally legal due to fair use and covers are also legal (as long as you pay the royalties) due to statutory licensing.
Interesting to read that it doesn't work on iOS Chrome. I tried it on actual device, it pops the alert and tells me to use Safari.
Why use a sign up when you could use HTML5 localStorage and users put the url and you redirect them..

Looks good anyways
Why we built a REST API for healthcare eligibility.
This is worth watching so I will break etiquette to bring more attention to this link: http://www.youtube.com/watch?v=0vcB7uCqdFk
This is at least the third time Glee has ripped off a cover and failed to give credit/royalties:

http://www.pleasewelcomeyourjudges.com/2011/11/greg-laswell-...

This is by far the most blatant: they even leave in the Coulton-version-only line "Johnny C"
I just looked into the code and found this: https://github.com/benvanik/blk-game/blob/cacacb4952554e77f3...
I don't know if it's still accurate; feel free to file a github issue or pull request if not.
I was hurt and depressed when my lover of five years left me for another woman. One friend suggested the idea to contact a spell caster, which I would have never thought of myself. I contacted a few of them but prophetharry@ymail.com was the person I felt good with. he was understanding, replied all my emails promptly and patiently. Then I decided to place an order for his spell even if at that time I was still a bit skeptical about his capacity to bring my man back with me. Only 1 week after the spell was actually cast, he returned to me and since then, it seems that there is no more mistrust and no more lies between us. For that reason, I am gladly leaving a testimonial on this page, which I believe will help persons to chose prophetharry for their case.
Words can have different meanings in a jargon than they do in the dictionary, but that does not make those meanings invalid. For instance, in computing "sane" means "I'm an overly opinionated git and everyone who disagrees with me is wrong."
Airpost.io - A RESTful API that unifies cloud storage for developers
Does anyone know of a tutorial or some skeleton code samples that allows you to build an embeddable website widget like this?

From what I can see, there are 2 iframes for the button and the hidden overlay. Clicking on the iframe button enables the overlay via some sort of iframe to iframe communication on the parent(host) page
Show HN: Tin Bull, an anonymous discussion board inspired by 2channel and reddit
That would be true, if it was attributed. But it's not. The only thing people will be downloading from this will be the Glee cover.
It's a defective battery on what amounts to an entirely new type of airplane. The A380 wasn't even a new type of frame, just a bigger one, and it still suffered serious issues. Guess what, it's flying as we speak.
That's why attribution is important.

Edit: What azylman said.
Files that aren't quarantines don't seem to end up in that log, unsurprisingly. No images, audio or video files, but applications and archives.
Entering someone's house uninvited is extremely clearly not an appropriate thing to do.

But accessing an unauthorized system? That term is so ill-defined, that it quite literally means you can be prosecuted for modifying a URL and being given back a web page you weren't supposed to see.
In SF and NYC:

Bike: $0 to maybe 25 per month in maintenance. You don't really need much else.
Not quite sure Scala is a good language to learn in. Learning curve is higher than other languages.
If you're sure the price is being manipulated low or high in the short term, then you have a very easy money making opportunity.
Stripe launches Stripe Checkout
I have tumblr dashboard as my home page because otherwise I forget to check tumblr.
This might be true if Glee gave credit to JoCo - linkbacks, promotion, etc. As it is he might see extra sales because he called them out.

Not to mention the long tail effect of "mentions" is really, really limited, and drops off fast to boot. Any extra sales he sees will all be today and tomorrow.

Only disingenuous used-car-salesman types would pretend that a footnote small-print mention is worth anything more than a sandwich.
Well, Ariely in this video is making the point that, as far as human nature is concerned, it does matter that everyone else cheated. It makes it socially acceptable.

If I were an honest competitive cyclist at the Tour de France level I would care that he doped. But if you believe the common wisdom, there were almost no such people :)

Anyway, Barry Bonds doped and so did a million other athletes. My point was that Lance Armstrong took it to an entirely different level by trying to destroy others to cover up what he did, and what he KNEW that others knew he did. It is really beyond brazen.
Http://www.Facebook.com/jamlullah
Wait, you put links for fisker-karma in there...

Yes, there was a recall, and Tesla recalled all their roadsters because there might have been a fire in a cable (not in the battery mind you), but none of the articles you pointed to showed that there was, ever, one Tesla battery system that caught fire.

I am ready to be disproved, but I'd need actual proof.
His description of the public reviewing system---and the idea of a review as a versioned public document that might itself contain new ideas---made me think of the state of affairs in the infancy of modern science, where the forerunner of the modern journal article was literally a letter to another scientist, which they would respond to with their own comments and ideas.
Are renting girlfriends a viable business?
The design decision of storing the application a file came from in file metadata, but the URL it came from in an sqlite database ... makes my head hurt.
Margin. It's always about margin.
Legit does the exact same thing that GitHub for Mac does.

"Once you're ready to share your commits, or pull in remote commits — just press the Sync Branch button. We'll perform a smarter version of pull --rebase && push that reduces merge commits but doesn't rewrite your merges."
Please read my post suggesting a tiered system. A tiered system would set limits in specific circumstances 'in stone' so that there isn't this idea that all computer trespasses can be sentenced on the same scale (e.g. from 0 - 30 years).

The specific circumstances can take into account things like:

- Did the defendant aim to profit financially from the actions?

- Was the defendant attempting to cause malicious harm? (i.e. he didn't want to profit, but he was trying to cause damage)

etc. The most innocuous being "no financial gain + no malicious intent."
July is the start of summer and it takes another month for the cold ocean currents from the north to warm up, keeping Santa Monica cool. An hour inland and it could be 110f. LA has maybe 300 sunny days a year, while Medellin is nowhere near the beach... like 1000km away.
Yup. IIRC a former roommate of mine has a plan on how to get every deduction under the sun to the maximum amount and it is actually possible to pay no taxes on like $100k, but it requires putting something like $40k towards savings each year.
Open a GitHub issue. I wouldn't be against removing.

In practice, the only ones I use are sync, publish, and unpublish.
Open an issue! Seems like a worthy edition ;)
C is itself a HLL, e.g it uses a high level state model based upon mutable variables rather then direct manipulations of processor registers and hardware memory locations.
If this is true, is there any evidence of cultural or technological contamination? Surely these seafarers brought a lot of new ideas and technology with them (such as agriculture).
Tell you what I'd like to know: what commonality exists between people who post these utterly unproductive expressions of incredulity in contravention of the very clear guidelines for posting here.
This looks somewhat similar to Unhosted's Remotestorage[1] specification.

[1] https://unhosted.org/
The best part was when I came across some random guy on Twitter that was trying to say that it was ok because JC is a 'nobody.' I couldn't tell if he was some sort of shill or just a random idiot (probably the latter).
Responsivity Analysis
It's amazing how geeks continually fall for Musk's simple propaganda. If you want to believe, you believe.
Strange Worlds: Photographer uses everyday objects to create scenery shots
This is beautiful, thank you :)
I'm confused. How does one simply play in the world? I see lots of docs for components and such, but no simple "Play here" button or link.
Very powerful, thanks.
I already own 10 shares of AAPL way before it went up to 500/700. Not selling anyway. Just saying... I'm not a trader in any way or form.
$350 USD, sorry.

Current exchange rate is 1.00 AUD = 1.05045 USD, though, so the AUS price is still wacky high.
Wherein HN is introduced to the concept of a "compulsory license" which makes this all okay (www.copyright.gov/circs/circ73.pdf).

Generally, the compulsory license requires royalties to be paid to the original copyrightholder of a musical work. It does not require the original rights holder to be publicly credited.

For examples of compulsory licensing in action, see...nearly every rap, hip-hop, or R&B song released in the past decade...
> The way both of you are talking about trading this stock indicates that you both aren't qualified to trade.
But then again - there aren't any tests to pass before one can trade - so trade away.
But remember - you both look like dancing pigeons to professional traders

Professional traders like this cat?

http://www.npr.org/blogs/money/2013/01/14/169326326/housecat...
How the Internet killed the Stop Online Piracy Act
I also don't leave my password on everything I touch.

Biometrics are a terrible idea. Password + token is much safer and infinitely revokable. And the server can even tell when an HOTP device has been cloned.
"This should be surprising to Marxists, given that, exceptional aberrations aside, information workers are members in good standing of the working class."

But there is not one "working class" besides in Marxist's totally obsolete and pseudo-scientific writings. This has been proved again and again. This all "bourgeoisie vs working class" does not exist anymore. It never did in Asia. And Marx himself admitted his theories were broken in that they couldn't explain the situation over milleniums in Asia.

Well, he was a bit harsh on himself, poor Marx: he was not all wrong. His theories can totally explain the situation in North Korea.

So the basic premises of this junk, just as any Marxist junk, are totally wrong.

Why oh why do poisonous words from communist websites are now getting upvoted on hacker news, a site dedicated to entrepreneurs, is totally beyond me.

Let's make a deal: all the communists who believe Marx's unfalsifiable (and hence non-scientific) theories are sound move to North Korea.

From there they can keep posting and upvoting communist junk on HN.

Seriously that said: for people who are unaware of the unfalsifiability of marxists' reworded theories (to cope with events that proved the first version wrong), these words are poisonous.

They are poisonous because they are carefully crafted to sound "scientific".

This article is, just like its mentors' writing, pseudo-scientific cerebral masturbation.

Life is too short and liberty is too important to pay attention to that kind of crap.
Because the option is almost always worth more to sell than to excercise, since the price of the option is the intrinsic value + the time value. The time value goes to zero as the expiration gets closer, where the intrinsic value depends on the price.

E.g., if you took an at the money (just at 0 intrinsic value) option for a year out, the price might be 20% of the strike price. That 20% will slowly fade over the course of the year. (Or possibly go up, if the volitility of the stock goes way up). If, in 6 months, your stock was in the money a bit, the option would still be worth more than the intrinsic value. (though, dividends can mess with that, and some people excercise options early to catch dividends)
More, it turns out that Valve ported Team Fortress 2 to VR (presumably the Rift) as an experiment, and they'll be discussing what they learned at GDC 2013: http://www.gdconf.com/news/valve_to_talk_head-mounted_dis.ht...
I don't know. Earning conference call happens at 5pm EST, after the market closes. Just saying that if you're an investor as opposed to a short-term trader, there isn't that much difference between 500 and 550 if it's going up to 1000, and there isn't much difference between 500 and 450 if it's going down to 200.

Of course many people will disagree but hindsight is always going to be 20/20, and many people like to pretend that they know something.
What a crazy coincidence, I just factored out my company's payment widget code into a reusable module a few days ago:
https://github.com/substack/pricing-widget

Basic example: http://substack.net/projects/pricing-widget/basic/
Fancy example: http://substack.net/projects/pricing-widget/browserling/
Like anything, 90% of it is crap, but there are a few good articles there. Just don't try to contest dividend growth investing, since they tar and feather people who don't believe in it.
Per Coulton himself, he hasn't found any definite proof of it being used in a Glee episode so far, so it's ossible that it;s some overenthusiastic fanboy/girl.

http://www.jonathancoulton.com/2013/01/18/baby-got-back-and-...
Good game! I enjoyed the first puzzle most, mainly because the second was a pain to write and I didn't think to allow backtracking in the second. I'm stuck, though, on the bonus puzzle; Is there a hint I'm missing? Brute-force doesn't seem a sensible answer.
You're very welcome. I'm reading what I've written and it seems overly critical of your work. I don't want you to feel that's the case; it does look like a wonderful tool and, in the case of a developer or a web freelancer, may be very useful indeed.

I look forward to seeing how this project unfolds and I appreciate you taking the time to read my suggestions.

Kevin
When did Roma leave India? A linguist's perspective on the controversy.
Google's Larry Page takes a swipe at Facebook and Apple
You're still tethered to the computer by the video and power cables, so unless you're being interrupted to do other things at your desk a lot I don't think this would help. Most of the time if I'm interrupted in a game it's for something that I can either do on my phone, or so something I have to do away from my computer.

That said, it would be an interesting experience to try wearing a VR headset for a long period with a couple of cameras giving a very wide view. I'm curious how well we'd be able to adapt to having 360° vision.
Interesting, but there's something eerie about deciding to strap on a helmet to re-visit a past holiday. Especially "again and again" :)

How often to we even browse our photos of old events, let alone 4D camera orb footage? Hey who knows, maybe that's how we'll be spending our twilight years.
Interesting you mention this -- one side project I wanted to work on was using the oculus rift to control a quadrocopter and simulate the feeling of flight. :)
There was a discussion along the same lines for GNU Encyclopedia. Shortly after, wikipedia got started. see https://www.gnu.org/encyclopedia/free-encyclopedia
wiredfool is almost right except in the case for dividend paying stocks. It could prove profitable to exercise before expiry date if the investor thinks the company is going to raise dividend because option holders don't receive dividend.
The enemy of my enemy is potentially useful.
Gym has worked with me in similar fashion.
Jonathon Coulton himself is relevant to many hackers due to to the intersection of his work with many tech/geek related interests including his authorship of numerous themes to computer games, songs about being an unappreciated programmer, songs about the Mandelbrot Set, songs about passive aggressive T1000 helper robots, songs about doomed ST:TOS red shirts, etc.

As for Glee itself -- I have nothing positive to say.
Also, "Still Alive", of course, at least among those of us who are also video-gamers.

But that aside, as a software developer I find copyright and other IP issues are very interesting and increasingly (and all too often in unfortunate ways) important to my field and I would find this noteworthy even if the subject didn't have obvious "geek cred".
Time did a review of the 747's debut in 1970:

https://twitter.com/QuipioApp/status/292098711121715201/phot...

New planes have issues. They'll figure it out. Grounding was the right call for now.
Open source game-theoretic poker player
Www.facts4lance.com
I don't understand his point regarding higher resolution displays as enablers of "flatter" design. Wouldn't textured, skeumorphic designs benefit as well?