I'm afraid the argument that C+ASM is always faster is flawed in reality. Pure ASM, with a bit of C thrown in, maybe, but this is just as impractical for complex codes as C itself is.

It is well known that for numerical codes Fortran beats the pants off C. Why is this? Because the structure of C programs proves difficult to optimise automatically. Indeed the C committee attempted to address one of the main problems by introducing the restrict keyword (the problem of course is aliasing).

For complex codes, ASM isn't an option. For large functions, high levels of optimisation aren't an option for C because C compilers are incapable of optimisation in a reasonable time frame: I have short code that cannot be compiled in less than 2 minutes on either gcc or clang. Full alias analysis requires data flow which is cubic order on function size and C compilers are incapable of partitioning functions to keep the cost down.

Furthermore, C has an weak set of control operations and an object model which is generally inappropriate for modern software. K&R C compilers were hopeless because of the ABI required the caller push and pop arguments to support varargs, preventing tail rec optimisation of C function calls.

Subroutine calling is useful, but it is not the only control structure. Continuation passing, control exchange, and other fundamentals are missing from C. These things can always be emulated by turning your program into one large function, but then, it isn't C and it cannot be compiled because the best C compilers available cannot optimise large functions.

Similarly, complex data structures which involve general graph shapes require garbage collection for memory management. With C that's not built in so you have no choice but to roll your own (there is no other way to manage a graph). It's clear that modern copying collectors will beat the pants of C in this case.

C++ pushes the boundaries. It can trash C easily because it has more powerful constructions. It had real inlining before C, and whole program compilation via templates. It is high enough level for lazy evaluators to perform high level optimisations (expression templates) C programmers could never dream of. And C++ virtual dispatch is bound to be more effective than roll your own OO in C, once the program gets complex because the C programmer will never get it right: the type system is too weak.

Many other languages generate C and have an FFI, some, like Felix, go much further and allow embedding. Indeed, any C++ program you care to write is a Felix program by embedding, so Felix is necessarily faster than C by the OP's argument: C++ is Felix's assembler.

As the compiler writer I have to tell you that the restriction to the weak C/C++ object model is a serious constraint. I really wish I could generate machine code to get around the C language. Its slow. Its hard to express useful control structures in. It tends to generate bad code. With separate compilation bad performance is assured.

I am sorry but the OP is just plain wrong. C is not assured to be faster, on the contrary, its probably the worst language you could dream up in terms of performance. The evidence is in the C compilers themselves. They're usually written in C, and they're incapable of generating reasonable code in many cases and impossible to improve because C is such a poor language that all the brain power of hundreds of contributors cannot do it.

Compare with the Ocaml compiler, written in Ocaml, which is lightning fast and generates reasonable code, all the time: not as fast as C for micro-benchmarks but don't even think about solving complex graph problems in C, the Ocaml GC (written in C), will easily trash a home brew collection algorithm.

Compare with ATS(2) compiler, written in Ocaml(ATS), which by using dependent typing eliminates the need for run time checks that plague C programs given the great difficulty reasoning about the correctness of C codes. AST generates C, but you would never be able to hand write that same C and also be confident your code was correct.

Compare with Felix, compiler written in Ocaml, which generates C++, can do very high level optimisations, which can embed C++ in a more flexible way than a mere FFI, and which provides some novel control structures (fibres, generators) which you'd never get right hand coding in C.

The bottom line is that OP's claim is valid only in a limited context. C is good for small functions where correctness is relatively easy to verify manually and optimisation is easy to do automatically, and any decent C code generating compiler for a high level language will probably generate C code with comparable performance.

So the converse of the argument is true: good high level languages will trash C in all contexts other than micro tests where they will do roughly the same.