skysight-inc/HackerNews huggingface dataset:
This is the third such study published within this year. The difference being that this study did full genome sequencing rather than exome (regions coding for proteins) sequencing.

The other papers:
O'Roak BJ, et al. Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature. 2012

Sanders JS, et al. De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature. 2012
A Touchless 3D Tracking Interface
I've been speaking with the author for the last year as he worked on the book and have reviewed it. Lot's of good material and a great read for anyone interested in building revenue generating side projects. I've got a few of my own side projects up my sleeve and this book helped inspire me to get going again. I'd recommend it, especially once the epub/mobi versions come out.
That's not the exception. Few to zero of the biggest technology companies were profitable the first month.
I'm willing to believe that. Actually, I'm happy to believe that, because it just always nags on me. You would be doing me a big favor by pointing out how it is more complicated than that.
It's interesting to observe that the VC rounds that are most often casually mocked on HN --- the huge rounds like Benchmark and then DST's in Twitter --- are, as proxies for earnings expectations presumably based on some very compelling inside information, a more meaningful milestone than many of small first rounds, which are often blue-sky.

As usual, even when the conventional wisdom of HN is on to something, it's for the wrong reasons and rapidly reaches the wrong conclusions.
Rewatchability and quality? Are you kidding me?

How do I glean from this wither of not I will like the movie?

A High quality movie can be terrible and a low quality movie can be great. What does quality mean? Does that mean they had good special effects and angles? Does that mean the color is true and the acting was great? How does this equate to me liking the movie?

Rewatchability? Many of my favorite movies I would not watch again (Lord of the rings) because they were so long. There are also so many movies that I want to see in the future that I will choose to watch one of them instead of re-watching one that I have already watched. Re-watching is something that people do less and less as they get older (kids and teenagers maybe do it) but adults (your target audience) not so much.

Also those scatter charts mean the same to my brain as the histograms that you are blasting so I would stick with what people are already used to (the histograms). You are not doing anyone any favors by changing the presentation of the same data. People are not stupid. They will see both equally in most cases but they will prefer the familiarity of the histograms.

Trying to be different is not always the best thing to do. As many have already mentioned. Use machine learning to augment ratings (like Netflix).

Good luck
There's a reason why fattening up cows causes them to grow bigger and taste better too. Chicken poop won't do that. You also don't feed old chocolate to tomatoes.
There are several.

One is to dump it in the Mariana trench, let nature
push it back down into the crust.

If we're foresighted, we'll bombard a crater in the moon with it. It won't go anywhere, and if we need to get it back, there it is.
High Resolution Video of Curiosity's Landing
3TB is a huge archive. I'm also not sure about your maths, billable peak hourly chiefly. [ed: dot multiplier for formatting]

Let's run 100GB, X. Allowance limit: 100GB . 5% is 5GB/mo, or per day, 100GB/(2030), 0.166GB/day; X/600.

Hourly rate necessary for a sustained 24 hour cycle of 100GB is: 100GB/24hr, or 4.166GB/hr, X/24. Peak hourly, this.

To determine the amount of data you get for free, we look at the amount of data retrieved during your peak day and calculate the percentage of data that was retrieved during your peak hour. We then multiply that percentage by your free daily allowance.*

To begin all that's stated here is, break your data-retrieval out over a day. Their example:

you retrieved 24 gigabytes during the day and 1 gigabyte at the peak hour, which is 1/24 or ~4% of your data during your peak hour.

We're doing 4.166GB in the peak hour/100GB in the peak hour, or ~4%.

X/24 / X = 1/24 = ~4.1666666% if you don't fuck your meteringly up.

We multiply 4% by your daily free allowance, which is 20.5 gigabytes each day. This equals 0.82 gigabytes [ed: free allowance hourly]. We then subtract your free allowance from your peak usage to determine your billable peak.

Free allowance hourly rate: 4.16666% . 0.166 = 0.006666, or (X/600/24), X/15000. A is at (12 . 1024)/15000, or indeed 0.8192 free, to verify.

billable peak hourly is then: hourly peak rate - free rate, 4.1666 - 0.00666 = 4.160, or (X/24) - (X/600/24) or (X-(X/600))/24 or (599X/600)/24 or simply, billable peak hourly will always be for sufficiently non-incompetent implementations: ~0.0415972222X. Always.

Let's check: 100GB . 0.041597 = 4.15970. Cannot compare to amazon, because their hourly rate is calculating a 24GB of 12TB archive download, but, 1-0.8192 still checks out. It would be 511.14666666 if their entire set, or (12 . 1024)/24 - 0.8192, 511.1808GB/hr peak hourly (nice pipes kids).

Retrieval fee is then, 0.041597X . 720 . tier pricing, and tier pricing I really do not understand the origin of at all but all examples seem to be 0.01. So, $29.95/100GB. For 12TB, say hello to $3680.25599 transfer fee. 3TB is $920.064.

720 . (599X/600) /24 /100, so for the transfer of your entire set X GB of data, evenly done across the day, you will be charged: (599X/600).(3/10)$,

0.2995$/GB to pull data out in a day.
Totally true. =)

I'm less concerned with the existential health of the cow, just health when growing and feed type. Both of these influence final meat quality, along with many other variables.

Example: Cows that were calm when killed are tastier.
Will there be a sequel? I want to be in it! :) I'm sure there are lots of us here that would be happy to participate.
Mind, this is the part of Instagram everyone actually cares about.
consider this one volume 1!
I was referring to the external bandwidth. Even if pulling down a request takes hours, forcing them to start off peak will significantly shift the impact of the incremental demand. I'm guessing that most download requests won't be for your entire archive - someone might have multiple months of rolling backups on Glacier, but it's unlikely they'd ever retrieve more than one set at a time. And in some cases, you might only be retrieving the data for a single use or drive at a time, so it might be 1TB or less. A corporation with fiber could download that in a matter of hours or less.
People who have children later in life are going to have a number of significant demographic difference from those who have children earlier.

Here's how you rule out each possibility: for each one, you pair up people in the "earlier" and "later" groups who have identical demographics. If the subgroups have identical outcomes, you have found the cause. If not, you have eliminated a cause.
A scientist might say, "There is evidence of causation."

Typically in scientific research, to assert causation three things must be true: 1) Correlation, 2) Temporal ordering (for A to cause B, A must come before B), and 3) Sufficient theorizing, in other words, a plausible explanation, typically based on previously accepted research.

In the best settings, random samples from a population with a treatment condition and a control condition are the best evidence. That's not possible in an age-base study, as randomly selected groups are not treatable with "age", and even if it were somehow possible, it probably wouldn't be ethical to do so.

Unfortunately, some of the most important research can't be done with this sort of A/B test.

Consequently, assertions of causation are sometimes incorrect. But that's true with any research methodology. Know that the question of causation is something the scientific community wrestles with, and a moderately informed population shouting "correlation != causation", while typically a good response to a newspaper article, isn't always the most helpful with regard to a scientific journal.
I wonder what the constraints on the background are? If it's not too fussy, then hang one of these around your neck and hook it up to an Oculus RIFT VR.

Immersive VR + hand-tracking == ????
Introducing Tent - the decentralized social web
Honestly, I don't think it's that hand-wavey when nuclear has killed less people ever than coal does every year.
I think right now our biggest problem is not energy sources but energy storage.

If we had an amazing vessel for energy storage, the sourcing problem would become relatively moot - there's so much available passive renewable energy, all we need to do is collect it.
Ah, the top-sense comment is the third one from the top. :)

A store that is also a movie theatre could do away with numeric representations by just watching what the users are doing with it's content. Things like "did they finish watching the movie?" or "did they get through the whole thing in one sitting?" could be helpful. Not to mention you can actually see if those titles were being watched again or not.

But there's still the problem of how to communicate the findings to the user, or formulate them.
I run a 13 person IT shop at a Big-10 university. If I were a single person shop, what would be different?
I wouldn't write code. I would be all about integrating off the shelf software into my systems. I would very likely be stitching University databases and third party apps together. I would be a call center and a support shop. I would be doing a lot of reading logs, Googling errors, and generally trouble shooting. I would be more than functionally literate on MACs, PCs, Unix, and MF machines. I'd know a reasonable amount about networking, and even more about SQL.

If you were going to roll this into a minor, I'd call it something like Applied Information Technology Management (or some mix of such buzz words). (Note: James K. badgered me into posting)
Your good intentions aren't relevant. This thread is critiquing a marketing message. I'm sure you're great at what you do, but the strategy of producing volumes of well-groomed data about your process will work against you with many managers, and isn't expected by any managers.
"and too many huge horizontally operated corporate farms that could produce, pack, ship and market produce more cheaply"

...presumably run by people with agribusiness BAs.
i'm one of the founders at backspac.es and i was curious what people thought of the story format that's produced. feedback is most welcome :)
Kiss your unfeeling computer goodbye
'Super PAC App' knows when political ads stretch the truth
Yes, but growth sucks. Assuming 3000 years in the article means what you think it means, consider exponential and linear growth:

If energy usage doubles every 30 years (pulled that out of my ass, it's not likely the trend but divides nice into 3000) then it will last us less than 200 years

If energy usage grows linearly increasing by the current amount every 30 years (so in 2042 we are using double, and 2072 we are using triple) it's lasts us a bit over 400 years.
The first non-ad result for me is mail.aol.com, as it should be.
That's kind of orthogonal to how you guess the user's language. It is, in fact, what Google is doing.
Incredible flying hover bike lets you fly over desert like a Jedi
In the article linked to from this article:

A preliminary report by the UN's International Atomic Energy Agency has stated that the response to the Fukushima nuclear incident was "exemplary" and that nobody has been harmed by radiation exposure resulting from it.

That seems to contract what the Japanese government's own panel concluded:

http://www.bbc.co.uk/news/world-asia-18718057
We can certainly examine the physical factors that lead to the human brain expressing and experiencing awe, morality, religious fervor, etc. But, that doesn't mean we should deny the power of those feelings in our human experience. After all they are the product of billions of years of evolution, and isn't that awe-inspiring in its own way?
Beat up Obama, Romney in 'Infinity Blade' creator's new political game
Actually, science does not allow for magic. Either something has an explicable mechanism by which it works, and that mechanism can be exposed through the scientific method, or it's supernatural. The supernatural is, by definition, inexplicable through science.

A black swan event is merely the occurrence of a highly improbable event. That says nothing of the event's explicability.

Edit: more accurate to say science cannot explain true magic, if there were such a thing.
It is a valid approach. In fact I'd argue that companies being profitable in the first month (or first year) are the exceptions, not the rule.

Another public example is Amazon, they didn't record a profit until 8 years after incorporation: http://news.cnet.com/2100-1017-819688.html
Satirical Kickstarter video trying to crowdfund CIA's "Trapwire" program
Indeed - same boat.

I wondered if Lewis Page's infamous and uniquely biased ramblings, particularly on any issues of nuclear power, US military or IP but in general any topic, would ever grace HN's front page. Guess that day is today...

I actually stopped reading The Register, before discovering Hacker News, just to get away from that "journalist" whose daily prolificness on that site alone was disturbing.
That's certainly how I hear it, too. I've never heard a woman expressing fear that she might have waited too long, such that her child will get Downs. Rather, fear that she might have simply waited too long, and now it is too late.
Intelligence vs. Effort
I imagine developing heart disease or diabetes later in life isn't particularly high on the list of concerns for beef cattle, considering they're sent to slaughter at a fraction of their natural life span.
That's fair. if you are looking for full functionality, I suggest you merge Parse's AnyPic (https://github.com/ParsePlatform/Anypic) with this camera picker component. IG is much more than just filters, but it is definitely a big reason they are popular.
rateyourmusic.com sort of has this, but it's not in the default view. You have to go to an album and click a "View my suggested rating" button, then it whirs for a few seconds before giving you an average of ratings from users with similar taste. It would be much more useful to browse the whole site with those ratings showing, but I get the feeling it's a computationally expensive feature.
Blogspot Down?
Well, seems so:
http://www.isup.me/blogspot.com

No blogspot blogs loading for me (in Goa, India)...
downforeveryoneorjustme?
History Of The “Entrepreneurial Revolution”
First of all, congratulations on your achievements in the field of condescension. I know how hard you and your team worked this year to reach new heights, and it has really paid off.

Second; at no point did I think it was a novel complaint. I'm well aware that it's an opinion that is both widely held and has been previously stated.

But that doesn't mean it doesn't need to be restated. Because the reality is that content-free blurbs about funding rounds continually get posted, upvoted, reprinted, etc. all over the tech industry as though they mean anything to anyone who is not directly involved in the operations of the company in question.

This should be called out as the meaningless crap that it is, and it should be replaced by actual content.
I don't find that beef ever tastes like tasteless cardboard, unless it is cooked completely incorrectly.

Without arguing about whether grass-fed beef is tastier in general, I wonder if anyone has ever done a blind test to discover if the grass (you know, the complex compounds flavoring the meat) can actually be tasted in the beef by an ordinary person.

As you observe, not everyone can afford grass-fed beef.
Would you give the government remote control over your router?
For anybody who codes in anything other than Clojure (although I have that too), you can partake of a 40,000 LOC elisp dotfiles repo.

I have shake-n-bake modules for virtually any language or use-case you could want.

https://github.com/bitemyapp/dotfiles/tree/master/.emacs.d

If you have any requests, I can probably bake it up. Included is the awesome Ensime package for Scala and Shime (Slime) a repl for Haskell. See the link to poke around for other things.

I recently restructured my dotfiles, but I once used my git repo to teach people at a Clojure meetup in SF how to get rolling with Emacs + Slime + Swank + Clojure.
On the more visual resume side, check out FolioSpace.me

Here's my profile: http://foliospace.me/scosman
Trello: Introducing Google Drive Integration
EC2 Cluster Compute Instances now Available in US West (Oregon)
I agree people are like that, although I am not sure more people are willing to self-install than pay for hosted.

You also make a good point about renewals. Because the cost of annual plans is out of mind for most of the year, it's important they allow users to disable auto-renew. I use Pandora, RescueTime and Forrst and they all have this option.
People are more frightened of things they don't understand, so effective advocacy of nuclear power requires making the effort to bridge the information gap. Also, people find concentrated acute harm more scary than dispersed chronic harm, which is why the idea of a plane crash is more disturbing than the larger number of people killed in road accidents.
This is only a problem for those who:

1. Are in the tiny minority of people in Japan who don't speak Japanese

AND

2. Chose to switch to Japanese when Google asked them if they'd prefer Google in Japanese or English

Google guessing that she might have been Japanese was not the major problem here. The ultimate problem was her incorrectly stating her language preference. It's hard to see what reasonable measures Google could have taken to inconvenience fewer people here.
Too late for me at 43 but it was the first thing I thought about too.

But I wonder can freezing sperm long-term cause degradation just as bad as it is for a man over 40 years-old?
Some data in support of that (granted not from a neutral source):

http://www.world-nuclear.org/info/inf06app.html
Since when? Are cows somehow the opposite of humans in that their fat weighs more than their muscle?
I think that's what is commonly picked up on, but I think Instagram's magic actually comes from how frictionless it is to share a photo and use the service. The photo filters are a part of that - the fun and quirky part - but its actually not what makes it special imo.
Usually current market value. It's discounted if it's considered high risk (and therefore has the possibility to tank).
I can not figure out why more effort is not put into thorium nuclear technology research. The only reason I have heard why thorium is not being considered is because it is not weaponizable. Are there any other reasons why thorium based nuclear fission is not being pursued as an energy source?
If that was easy, it wouldn't be standard practice at corporations to disallow it. In most large companies, if you are in a relationship with someone in your reporting line, one of you has to transfer or leave.

Even if the reality is that there's no favoritism, it opens you up to lawsuits both from the people who are involved, and from their coworkers. If they break up, and then he demotes her or lets her go, lawsuit city.

I've seen this firsthand at a major venture startup (but wasn't involved in it myself) - a fiancee/employee decides to leave an officer for one of the other officers of the company. Disastrous for the company.

Anyway, it's their company, and I respect that they can do whatever they want - I only raised this issue because it happens fairly often in the startup world that a very tiny company wants to hire someone in a relationship with an existing employee, and there's a lot of issues you bring on board when you do that.
Why I will never hire a designer at my next startup
Warning: shameless self-promotion ahead:

db = require('./your_sexy_data_access_module')
server = require('lazorse').server port: 3000, ->
# in this context we register resources the app using @resource
@resource '/things/{thingId}':
shortName: "Things"
GET: ->
db.getThing @thingId, @data
POST: ->
db.getThing @thingId, (err, thing) =>
return @next(err) if err
thing.update(@req, @data)

Where @data is node-style callback function taking (err, data), and the data will be rendered by a separate middleware layer that inspects Accept headers and does the Right Thing.

There's a lot more than should be covered in an HN comment, but in interest of DRYing out the above example, let's rewrite it to use a coercion to retrieve "thing" instances.

db = require('./your_sexy_data_access_module')
server = require('lazorse').server port: 3000, ->

@coerce 'thing', "Things are whatever this app deals in", db.getThing

@resource '/things/{thing}':
shortName: "Things"
GET: ->
# Use @ok because we won't get here if there was an error retrieving
# the thing
@ok @thing
POST: ->
@thing.update @req, @data

See http://betsmartmedia.github.com/Lazorse for full API docs and examples. Bug reports, pull requests, flame comments etc. are all very welcome :)
How the transistor got its name
A Website To Crowdfund Your Wedding
These are disorders that effect a person's personality, which could mean all sorts of new variables to control for. A man who has mild symptoms of autism or schizophrenia may well take longer to establish himself in his life and have children.
John Cleese on the Origin of Creativity
The difference being that it's just the amount of money involved that is driving the reprinting of the press release, not the worthiness of the recipient or the track record of the VC. It's just "Oh millions of dollars! Let's repost this!"

Like I said originally; I'm happy for anyone who gets funding to pursue their project. Great for them. But it doesn't affect me at all, especially since so many of them are so early in their development they don't have anything to talk about it. It's just a waste of anyone's time who's not involved.
Big thanks for including our site! When I have some time over the weekend I'll be reading all the other interviews, but from the two others I've read so far, this book should be very informative for people getting into bootstrapping a business. Nice work!
So have Vietnam, China, and Iran.
Phone numbers are not traceable. Google voice, etc.
I could also argue that's exactly WHY to use factory girl in unit tests. You're not using FG to create the things under test, only the things to pass to the thing under test.

Complexity is a moot point for those extraneous objects. You want that complexity out of the tests since it's not the focus of the test itself, and makes it more readable.

But I'll take this one step further. To each their own. There is no one exact correct way. Do what's right for your code, domain, and tests. I wouldn't test an API codebase the same I would a site codebase or a gem codebase anyways.
Anyone know who the author of the book is? I can't seem to find his name on the website.
Study Suggests Skill Is An Important Factor in Online Poker
I believe the charge is that they've done or avoided doing some very specific and otherwise natural things to avoid falling under banking regulation.
>Asperger’s syndrome... will be folded into a single broad diagnosis, autism spectrum disorder

^ FTA quoted as a source.
It's not going anywhere, just re-labelling. There are definitely things behind AS, it's certainly not all just 'hullabaloo', even if a lot of cases might be.
The typical environment variable for socks proxies is SOCKS_SERVER, so: export SOCKS_SERVER=127.0.0.1:8000 in conjunction with ssh -D8000

Unfortunately many utilities don't support SOCKS or have non-standard flags, so you would need a wrapping program like tsocks to force TCP through your proxy.
'; CREATE TABLE `Capture the Flag`;' -- Stripe's Web Security CTF is Live