skysight-inc/HackerNews huggingface dataset:
It could be the biggest drug. It might get out of phase 3. It may get approval very soon. And of course, "may be a game changer."

When the news is this fast and loose with anything that even looks like a fact how am I not to see this as rank manipulation? There is nothing critical in this article except for how hard doctors and insurance companies might be pressed to prescribe it.

Then they end with this gem:

"But Seigerman said it will also put pressure on smaller companies developing pills, such as Structure Therapeutics, to find a partner that can help them compete in the weight loss drug market with pharmaceutical behemoths like Eli Lilly. "

Oh. I see. It's not just manipulation but dumb protectionist gate keeping.

Depressing.
Yes. 10 meter range, must have line of sight to the radioactive material. When does that come up in practice?
Physical attractiveness far outweighs other traits in online dating success
How much foreign aid is spent domestically rather than overseas?
I've met plenty of farmers who are obese and have a variety of musculoskeletal ailments.
When, precisely, did the US stop doing that?
I have ADHD. Here's my story:

1. I can focus and solve hard problems, but you’ll notice my legs swinging restlessly, hand gestures, or me suddenly typing a completely unrelated web address.

2. I was always a great student, but I was also the most restless; making jokes and talking constantly, no matter how hard I was punished for my behavior.

3. The toughest part of my ADHD is inconsistency. My performance can fluctuate a lot, and it takes tremendous effort to stay consistent. I get bored quickly with easy tasks, so I rely on alarms, calendar events, and other reminders to help me stay on track.

4. People like me are prime targets for distraction businesses, whether it’s social media, gambling, or other addictive behaviors. And a lot of my energy goes to resist them.

All in all, even for a functioning person like myself - managing ADHD takes a lot of effort. In my late 30s, I’m finally feeling a bit more in control. I’ve accepted that this is part of who I am, and while I can’t fix it completely, I’m doing my best to avoid letting it impact the people around me.
TFA doesn't really explain how is this better/cheaper than existing ADSB based technologies, or where one is more appropriate than the other (ie which use cases it's targeting)?
I tend to find it's causing things even if I'm trying to avoid essentializing it, and this also goes for side effects of medications for it.

eg relationship advice says you shouldn't "change your personality" for your partner, but in my last relationship both of ours changed quite a lot when our medication changed or even if we hadn't taken it that day, so I don't really feel attached to it.
I feel like you are trivializing the dogged, uncompromising and ceaseless war liberals wage against common sense and decency.

I'm sorry but when the other side of the war wants me to pay fines, go to jail or be expelled because I subjectively hurt someones feelings I gotta go with the church whatever their faults
Edison gets credit for inventing the inventing business.

The Wrights get credit for the first directed research and development project. (The Apollo project took that to an extreme!)
Thank you for thoughtful post. I know near nothing about Sufi religion. Sounds enlightened and good for them/you! My words were very influenced by frustration rooted in my experiences in US, especially as of late.
This is cute, but please don’t. If you don’t have perfect vision or dexterity, whether due to permanent disability or temporary impediment, this is a nightmare to navigate.
would it be better for energy efficiency and overall performance to use workstation cards like A5000 or A4000? Those can be found on eBay.
Haven’t seen the series yet, but I do have some exposure to the underlying problem.

Online bullying and social media pressure are real issues that cannot be ignored. At home, we tackle it by appropriate parental controls, education, and transparency. However , we are privileged to have the time, money, and awareness, for this to happen.

I genuinely feel we need some generic change, somewhere, (I don’t have answers) to incentivize companies to do the right thing to discourage continuous engagement and also build the right set of judgement skills needed by teens to navigate online social space.

It probably starts at home and perhaps an online social media class in school.
At a previous role, we used DryStructs for this, which seemed like a nice way of getting:

* named variables
* type validation
* better documented code

https://dry-rb.org/gems/dry-struct/1.6/
> it just wide the inequality gap.

It didn't. Yes, the gap certainly has widened with countries that didn't partake in globalisation. Here I'm thinking countries in Africa, North Korea and Afghanistan.

But if you look at poorer countries that did invite the richer ones so that could provide labour at a lower cost, countries like Vietnam, Thailand, South Korea, and yes China - the gap has gone from peasant farmers who starved in lean years to industrial nations that are starting to rival the incumbents. Places like Singapore and Japan are in fact now wealthier than most of the incumbents.
What is the memory of your NV3060? 8GB?
There’s so much survivor bias in these comments.

We know what happens when ADHD is underdiagnosed and not recognized in society (which requires it to be labeled appropriately). You have scores of children who get labeled as “problematic” or “bad students” ans suffer from that discrimination for the rest of their lives.

Labeling may not help a particular individual but helps all in society as a whole
The Berkeley Function Calling Leaderboard [1] might be of interest to you. As of now, it looks like Hammer2.1-3b is the strongest model under 7 billion parameters. Its overall score is ~82% of GPT-4o's. There is also Hammer2.1-1.5b at 1.5 billion parameters that is ~76% of GPT-4o.

[1] https://gorilla.cs.berkeley.edu/leaderboard.html
No, it's not a reformulation of tirzepatide. Orforglipron is a small molecule with a molecular mass of 883 g/mol and tirzepatide is a large molecule peptide six tims larger, with a molecular mass of 4813 g/mol.

The Wikipedia pages are decent -- the picture makes it fairly obvious how much smaller orforglipron is than tirzepatide even if you don't know how to read chemical structures; just count atoms!

https://en.wikipedia.org/wiki/Orforglipron

https://en.wikipedia.org/wiki/Tirzepatide
Yea, computer is indeed using a lot of resources more resources than what average non-dev ppl use.
> only one of the two devices needs to be exploited

I think we must be thinking of very different things here. Maybe I misunderstand the scheme you're objecting to. Would you mind elaborating?
The chart you show is about the accuracy of x*y where X and Y are an increasing amount of digits.

This graph shows that both o1 and o3-mini are better at calculating in one’s head than any human I have known. It only starts to break down towards calculating the product of two eight digit factors etc.
“unauthenticated attacker with access to the pod network” /yawn
Phase 2 clinical trials showed 14.7% mean weight reduction at 36 weeks in adults.

That's pretty substantial. Obviously no one knows what Phase 3 will show, but cynicism seems unwarranted at this point.

https://investor.lilly.com/news-releases/news-release-detail...
I now think of myself as being the lucky one who gets to be at the right place and the right time, experiencing the act of creation is a gift from everything and everyone else that helped make it possible.
Show HN: I made a release of our project on DevHunt
Hello everyone!

Recently, I prepared a release of our project on DevHunt and there was quite a good number of upvotes and there are literally a couple of hours left before the results are announced. I think that the release turned out well and it may take first place. But even if not, then it’s good try. Thanks you!
> as long as you include information the user can use to dedupe manually

There is an existing standard for this in the form of the message-id header.
You can buy "heirloom" seeds for just about anything you want to grow without any IP concerns. The genetically modified seeds are mainly only of interest to large farms growing huge amounts of staple row crops.
Interesting recent video on ISBNs and their relationship to barcodes: https://www.youtube.com/watch?v=68vS8CTBL3k
Extremely long post, eh?

I think programmers - good ones at least - like building things, like seeing things go. We care deeply about what we can make in the world. We are in a OODA loop, where we put in effort, fix things, and they get better.

But often building stuff becomes jammed up, organizationally. There's other people injecting priorities and concerns. There's a whole org, that's utterly dependent on us, that thinks it want things, but don't understand what we are bargaining over, doesn't have the essential capabilities to see the truths, affinities, struggles, and joys we feel. We're on our own island of empathy with products. And the outcome is always so unknown, riding this organization ship.

The idea of going out there homesteading speaks, to me, to a desire to have a loop where there's less people injecting themselves. A very recent highlight from Tools for Conviviality (Ivan Illich, 1973) comes to mind,

"Survival, justice, and self-defined work. I take these to be fundamental to any convivial society."

Via https://bsky.app/profile/gordon.bsky.social/post/3ll5hgh3el2...
Aren't they just waiting for the active camouflaging technology to catch up? Normally, we think about that as something on the underside of the aircraft so that it appears invisible from the ground... but the same principle could apply to the top side of the aircraft if it ever becomes viable.
If the function is long, accumulate variable along the way, and open intertwined control flow every three lines, no a single function is not at all a scalable way to expose a construction involving many transformations and sources and debugging will be as hard as the control follow depth times number of stacked variable so far as it's stepped through.

With method chaining at each step you have only the complexity of the current method inputs to deal with: that's a far better noise/signal ratio.
Money money money money moneeeeeeeyyyyy.
> This isn't just an oral formulation of tirzepatide, right?

No, the molecule (per wikipedia) is significantly smaller.
That stupid scroll wheel is so great I hate it. I also can’t give it up. Sometimes I want smooth, sometimes I don’t.
Framed this way, it seems obvious that drones and UAV would arise out of this "evolutionary pressure" on aircraft.
With BCPL

https://web.archive.org/web/20250130134200/https://www.bell-...

See also this comment https://news.ycombinator.com/item?id=43462794
But it would be pretty cool to have a coal mine on your property and you could go down and like dig up a piece for fun. Have you ever looked at a piece of coal under a microscope? they can look pretty cool!
I don't appreciate being called a liar and I am happy to debate this with anyone else who was actually there.
The product requires crime? I feel like most products do not require crime. This is not a good sales pitch.
The fertility rate in India is only slightly above replacement. The fertility rate for China is well below replacement.

https://www.macrotrends.net/global-metrics/countries/ind/ind...
https://www.macrotrends.net/global-metrics/countries/ind/chi...
Authentication? ADSB isn’t authenticated. Anyone can emit, anyone can spoof, and I probably shouldn’t say that over the wire. The FAA said in 2012, when the conf at Defcon was made, that it had its own secret mitigation.
Their point is that with AI generation, (3) is already possible to hide.
Sounds like "Oral formulation GLP-1", which is what it is? That won't be the brand name.
The sentence from the article is:

"While the total amount the Greens have made in charitable contributions has been kept private, former Oral Roberts University president Dr. Mark Rutland may have worded it best when he described the family as “kingdom givers”.

It doesn't link to the Forbes article's definition. Without more, I'd read that sentence to say "Kingdom givers" is a descriptor of the total amounts given by the Greens -- we don't know the amount, but they give kingdoms.

As I explained above, "Kingdom" is unrelated to the size of the gift, as made clear from the quote you cited.
I recently learned about https://en.wikipedia.org/wiki/Self-verifying_theories which gives you most of multiplication while still being decidable, which is pretty crazy.
Cult: any organization formed that leads to the leader having more sexual partners than societal norms allow. E.g., Ayn Rand, David Koresh

Its not difficult...
It does say it in those two later sentences you quoted:

But unlike those three medications, Eli Lilly’s pill is not a peptide medication.

But so-called small molecule pills [orforglipron] will at least be easier for Eli Lilly to manufacture than injections.

In medicinal chemistry parlance, a "small molecule drug" normally means one that can be synthesized by flasks-and-beakers organic chemistry of the sort one learns in an organic synthesis class. (And it has a lower molecular weight than peptide or biologic drugs, hence the name.) Peptide drugs are synthesized by a specialized kind of organic chemistry that mimics aspects of protein synthesis:

https://en.wikipedia.org/wiki/Peptide_synthesis

The industrially relevant thing is that small molecule drugs typically cost less to produce, once the molecule goes into full scale production. Lower cost is an advantage for the first manufacturer while the drug is under patent and it's an advantage for buyers once the drug's patent exclusivity expires.
> It feels very Sisyphean at times I suppose

I feel this every time I touch CSS. Sometimes I spend hours just fiddling with it, and my code commit is a few characters. And what's worse, it's the thing I stumbled on in the first 10 minutes of debugging, but that, for some reason, never worked that I tried again out of desperation, after not getting anything else to work (an hour later) and that I'm now trying again for some reason. Yet, for some reason, it works this time. CSS makes me feel stupid.
> Meanwhile, pictures are trivial for humans to verify against a simple search

The majority of people do not have a picture of them on the Internet.
> The company reportedly plans to discontinue the offering in all its future models soon in favor of its own built-in in-vehicle infotainment systems.

The thing you wanted as a consumer is inconvenient to our pocket book so we're removing it for something worse in every conceivable way.

> According to the report, 85% of car owners who have Apple CarPlay (or a similar service) prefer it over the OEM’s built-in system.

Let's check with Jeep owners on that one.
How to download and install the app? There are no instructions.
It was my understanding that you can only block aftermarket parts that affect emissions and safety, and that the onus is on the car maker to prove that it affects those systems.
These seems overblown since because configuring your ingress controllers and annotating your pods is like "I copy and pasted bash | sudo" but controllers in k8s are a totally insane pattern so I guess any of them could steal/do a lot of evil, really.
It will be a miracle if GM is not completely bankrupt in 10 years.

This company is completely on the wrong track in almost every strategy decision (giant cars, ICE heavy lineup, quixotic war on Apple CarPlay, etc.)
China's trade abuses are insane. Firstly, china has better than 80% marketshare. Most people agree that a monopoly of this size is net corrosive to innovation and competition. What's more, china massively subsidizes industries she prefers. Both in terms of direct subsidies, but also in that the PBOC can direct any and all banks through the country to offer privileged terms on loans or capital. This often doesn't factor into western analyses because it's simply not a tool we use. It's also not the sort of thing WTO/GATT rules are written to consider, see prior comment about the system not being set up to deal with chinese. You're right that there's less evidence of explicit dumping under international law, though since the domestic chinese solar market is so much smaller that's not an entirely meaningful number, but I was using it more as a colloquialism people would recognize to indicate state-backed overcapacity to knock out competition than as a legal term of art.

And you're assuming being stuck under the thumb of an illiberal regime hostile to our beliefs and way of life, a regime with a long history of violating basic liberties, of mass murder, and of ethnic (han) supremacy, would stop at trade concessions. I don't believe we could reach a point where we could make tolerable policy changes to appease the PRC.

I don't think it's an issue of us being blind. There are plenty of contributing factors. For one, we are terrible at industrial policy and it's ridden with recapture. E.g. Ford shutting down a battery plant because the UAW demanded (and gov't generally supported) the fact that they'd have to re-hire and re-train tons of UAW employees at the new factory. This is objectively not the way to handle what we believe to be a critical energy supply issue. The fact that it's become incredibly difficult to produce solar panels or batteries competitively, both due to higher wages and more stringent regulations than one would find in china. This is exacerbated by decades of conspiracy to wink-and-nod at illegal immigration suppressing investment in automation, meaning catch-up would be painful and take time. Etc.

There's also the fact that, as it stands now, we cannot replace our grid with renewables. It's also much easier to make a large chunk of it nuclear, but the environmental/clean energy groups have mostly been captured by nuke-hating tree-huggers for half a century now. Objectively you do not want to make all your generation wind/solar because your storage requirements are much higher, because the LCOE numbers people use in their calculations (Lazard's are popular) are notoriously bad, and because storage tech either isn't there yet or is cost-prohibitive.

I am very frustrated by people who 1. try to reduce this to "one simple thing" that they happen to support, and likely supported long before and apart from current issues, 2. people who see it as an opportunity for recapture, and 3. the head-in-the-sand denialists who just don't know or care that America's position and people are threatened by the way things are headed.
The network effect also works in reverse. The collapse of a network can happen very quickly. Facebook wasn't just functionally better than Myspace. Myspace experienced two really bad things at once, uncontrolled spam and adding display ads, at the same time, in 2008. It was easy to get users to just lose their daily Myspace habit and replace it with Facebook.

LinkedIn is unlikely to be mismanaged as poorly as Myspace was but there will be openings for competitors. Myspace and Facebook were unique because they were both very interchangable at that point, although Myspace was kind of like the "public" internet while Facebook had already dropped the edu email requirement, it was still heavily skewed college educated at that point.

Also worth pointing out, the edu email addresses requirement for Facebook likely did a lot for keeping their early network clean of bots and spam at a minimum cost. LinkedIn, on the other hand, basically hijacked their user's address books and sent out email impersonating those users, meanwhile ignoring unsubscribe requests and spam complaints. Which certainly sounds like something someone would end up in jail for doing (they did get in trouble for this.)
Appreciated.

When I say more dangerous, it’s just a pretty simple calculation - per watt of energy, how many people have been injured/killed when producing energy via a given source. Coal is incredibly dangerous, as is gas by this metric. Nuclear is far and above the safest when calculating in this specific way.

Solar and wind are inefficient, by my definition, because they require large portions of land and cannot run with highly predictable outputs at all times. As a result, you need other solutions to complete the story - larger farms, more farms, large batteries, grids that easily transfer energy long distances, etc.

Nuclear is able to sidestep all of those problems, especially with the relatively recent advent of small modular reactors (SMRs).
Mentioning the military might give you a hint...
Why do you always take every opportunity you can to try and discredit me on this? Anytime someone mentions me, boom, there you are, in every social media, everywhere, being the first to try to discredit to me. As a spokesperson for a competing project, I'd expect a higher level of decency than spreading FUD like this.

I'd be happy to discuss and debate this with you, but you weren't actually there. I tell you what, go find someone else who was actually there at that time, and I'd be happy to discuss it with them publicly.
You didn't ask about Australia, but it has https://forums.whirlpool.net.au/

It predates HN and always has always been the place the best technical people in Australia butt heads. Their problem is they aren't up to the same standard as here - where you have the best technical people in the world butting heads.
Safety standards do change for the better, but insurance and legal risks do have gyms on edge. I think his point is that gyms tend to be overly strict in areas that do not matter, but are easy to regulate/check. I.e requiring you have an unnecessary “backup” knot above your figure 8, requiring 2 Tri-locking carabiners for autobelay in response to accidents where people simply didn’t clip into the autobelay, knowing your gyms mnemonic for checking your knot, and disallowing wearing a single earbud when autobelaying (saying you won’t be able to hear if there is an emergency). These are all things I’ve seen required in gyms that IMO do not actually improve safety. Having friends that work in gyms, I’ve heard a lot of these policies are due to demands by insurance companies.

Meanwhile, I very frequently see people belaying in manners where their climber would hit the ground if they fell (usually the first 3-4 bolts up). The difference is, this is much harder for gym staff to notice and correct. Furthermore, I’m sure most of these climbers are capable of using better technique and do so when taking a belay test, but then get complacent afterwards.
LLMs and Space Systems
I've been reading up on papers related to the intersection of LLMs and space systems. I am (and always have been) very pessimistic with regards to the decision making capabilities of LLMs. However, every paper I read seems very bullish on the use cases of LLMs as spacecraft operators, decision makers for observation scheduling, and controllers in autonomy. Curious to hear the thoughts of others or connect with people in the field.
Break down the range of x values from -1 to 1, and y values from -1 to 1, each into 1024 parts (or whatever resolution you want to plot at). Evaluate the function for each (x,y) coordinate. If the resulting number is negative colour the pixel white, otherwise colour it black.

The expression is (probably) a 2d signed-distance function - https://en.wikipedia.org/wiki/Signed_distance_function
You may or may not be correct, but I'd say, citation needed.

It's not self-evident that life is such a zero-sum game that more people necessarily means fewer resources to go around; I'd even venture that the last hundred years of development suggests the opposite.

It's quite possible that more people enables a slew of network effects (such as technology improvements due to more minds attacking a problem, say) that improves everyone's living standards.
Perhaps I should have been explicit that I meant "say it explicitly," though I thought it was pretty clear.