skysight-inc/HackerNews huggingface dataset:
What do we believe the discovery pathway was? Billions of dollars spent by heady businessmen with a keen eye for the molecules of interest? Hardly:

https://www.pnas.org/doi/10.1073/pnas.2415550121

And this type of drug lends itself to some of the least expensive trials you can hope for. The dosage level, expected dosing period, and measurement of outcomes are all uniquely well suited to inexpensive study. The trials were also exceedingly fast and quickly broke off into testing for all kinds of conditions such as Parkinsons but for the core case of weight loss it was as easy as it gets.
On security focused distros, it obviously works in neither browser right now, because it's a fucking stupid idea.
I heard tutanota collaborates with German law enforcement for decryption.
Some aspects of experience— e.g. raw emotions, sensory perceptions, or deeply personal, ineffable states—often resist full articulation.

The taste of a specific dish, the exact feeling of nostalgia, or the full depth of a traumatic or ecstatic moment can be approximated in words but never fully captured. Language is symbolic and structured, while experience is often fluid, embodied, and multi-sensory. Even the most precise or poetic descriptions rely on shared context and personal interpretation, meaning that some aspects of experience inevitably remain untranslatable.
I agree! But I also think that encoding, in terms of how popular an encoding becomes, is not purely concerned with "efficiency" or "space optimization". There's something more metaphysical or at least artistic going on. It's about aesthetics, to some extent I think. The universe wants these little symbols to be born/representing things - if you wanna go that far, haha! :)

b64 succeeded because it's...kinda beautiful. It's not the most "efficient", or whatever. But it looks gorgeous. Enough variability in appearance, to keep each little (or long) slug interesting looking. No weird font issues with symbols replaced with opaque, error-looking boxes. Just the raw beauty of English language and its alphabet.

There are more efficient encodings still (like the unicode base 65536 or whatever), well designed, hyper optimized -- but they don't really take off. I think one thing is aesthetics. And...what you say - KEEP it SIMPLE! :)
> worst case it will be replaced like the British Empire,

Didn't something similar happen to the Roman Empire? It just kinda ... slowly broke apart?
Is this quote an example of making the issue seem larger than it is? Measles ”feels” very common although at any one point I guess not that many people have it, but many see it in their family or remember experiencing it. So it feels like a large number. Saying that there are less people in some group does not make it sound that small. Why not say there are under 100 poeple or whatever the number approximately is?
Surely horse-centric was a lot better.
It is, just like having an armed policeman permanently stationed in your living room to protect you is a legitimate use case.
> The current US administrations moves against renewables

It is promoting electric cars fairly forcefully.
I would point out that having raising radical right is still waaaay better then having them ruling the country ... and have zero checks and balances applied to them. Which is the case of US.
This Week in Plasma: File Transfer Progress Graphs
Concepts is nice. Subscription model IIRC but I’ve been happy with it. Nice options for different papers, can cut and paste/transform objects. Has multiple layers.
Cities don't work like that. When you have less traffic, people start to squeeze in (real estate is rarely a limiting factor), and you get more people and more traffic. People want to live densely, and they will.
And the number of hydrogen powered vehicles sold year on year is currently decreasing. As are the number of places to fill them up in the UK at least.
eh, he's a pretty garbage person with a long list of sidekicks who have done crappy things. Sticking up for some kids for likes on youtube doesn't negate his long list of crappy actions.
BunnyCDN has a great product offering, particularly if you've used Backblaze B2 as "ultra-cheap" object storage, the BunnyCDN product is very competitive pricing-wise, and the CDN configures seamlessly with it. And you can set up a cheap image transform proxy on any of your CDNs.

R2 is cheaper though if you storage cost is less than your bandwidth cost, and B2 has a feature to automatically expire items which depending on your design might make it more efficient.
Porkbun is $11/yr for .com. Namecheap is the same standard price but namecheap regularly has $6/yr sales. .coms are $6.50 on namecheap right now vs $11 on porkbun.
What are other barriers in transformers? Or is the normalization layer the primary one?
I've never used namecheap for anything except setting nameservers. I don't see why you'd use a registrar for anything else.
Yes, Gibbon makes for interesting reading. Decline can indeed be prolonged. I suppose it's like how some things get very slowly better over the decades, other things get very slowly worse over the decades.
We don't know how memories are encoded in the brain, but "electricity" is definitely not a good enough abstraction.

And human language is a mechanism for referring to human experiences (both internally and between people). If you don't have the experiences, you're fundamentally limited in how useful human language can be to you.

I don't mean this in some "consciousness is beyond physics, qualia can't be explained" bullshit way. I just mean it in a very mechanistic way: language is like an API to our brains. The API allows us to work with objects in our brain, but it doesn't contain those objects itself. Just like you can't reproduce, say, the Linux kernel just by looking at the syscall API, you can't replace what our brains do by just replicating the language API.
Bravo!

This is how Vaudeville was born :)
What Horizon Zero Dawn actor Ashly Burch thinks about Sony AI taking her job
where did i mention politics? stop reading what you want to read.
The ones who can afford it have been building bunkers in New Zealand and Argentina, but if you sincerely believe a civil war is on the horizon, almost anywhere would be a better option.

The Russian invasion of Ukraine had a negative impact on international markets, but if you were from either country you would have been better off living abroad when it happened.

Similarly, you would be better off almost anywhere outside of Europe from 1933 to 1947.
Ever met a diesel mechanic? Every one I've ever come across has a very distinctive diesel cologne. I worry how this plays out in the field when combined with a 10,000psi gas which is explosive is almost any mixture including oxygen.
The USSR was in a far worse position than the US is in. They had to build a wall to keep people from walking out. The US on the other hand is financially irresponsible. It can't afford a global Not-An-Empire any more because its economy is no longer the world's unchallenged largest but it isn't in a bad state in absolute terms. The scale of the challenges just aren't in the same league.

Unless it decides to go down fighting and gets something important blown up it could easily remain a nice place to live for centuries. Nobody threatens the US, it is hard to see how it'll ever be in anyone's interest to threaten them, they can re-learn how to be an industrial powerhouse if they have to. Almost all its real problems are ill-advised domestic policies that can be changed pretty quickly if people decide the situation is hairy enough to be honest in politics.

It might be in everyone's interests for the US to dissolve but it won't be as bad as the USSR dissolution was. It'd probably be a good outcome if they went back to the constitution as intended, depowered the federal government and became a collection of powerful states. A lot of the political tension is because whoever wins the fight over controlling the central government ends up with far too much power.
What do browsers do that they weren’t meant to?

The only thing that comes to mind is password management. But I would also argue that’s a boon for normal users and trust in the web.
I've used their CDN for the past 4 years. Their pricing is extremely competitive (cheap) compared to everyone else.
Say Goodbye to the Google Assistant–Gemini Is Moving In
That is why the standard is two (or more) independent sources.
Well you actually make a point for short reaction standardized support.

You won't be able to alter behavior of everyone around you. So at least the software should render these interactions in the least obnoxious way by being consistent on both side.

You will always be able to ask for textual clarification. But the big win is that you won't be bothered by sub-par quoting repost.
+1

They had the altimeter fail on the previous mission too. Seems like a fairly crucial component of a moon lander.

Armchair rocket scientist here, but if I were on that engineering team I'd lobby hard for less science payloads and more backups for critical instruments for the actual flight of the craft.

The rover and hopper and drill etc all sound cool yes, but worthless if you can't land. Again. For the second time. Because the same critical component failed, again. With apparently no backup, again.

Of course, it sounds so simple. I am sure there is more to it (e.g. perhaps they had backups and everything worked, but they just weren't fit for purpose?)
My hunch is that google uses it for something internally or there's some random government agency that uses it so Google can't quite retire it yet.

Or Gvoice is some backbone service that something else uses. Idk, but it has to be used for something for Google to have not killed it yet.
I don't pay for Netflix and a rival good (like ISP infra) is completely different from some compiled computer code (like a browser).
because they can’t support the same functionality. apple would add something new, they would want no constraints to what they can do.
Measles are not common nor were common for decades. There are simply not many people who have seen it.

There were also no deaths from measles for 10 years, because, well, not enough people had measles.
Hybrids are better for road trips in my experience. We have an EV and a hybrid, and nearly always choose the hybrid for road trips, because the EV needs to stop 2x as often, for 3-4x as long.
I'm being sarcastic. I'm vegan.
> I have trouble seeing how they help anyone.

That sounds like a problem unique to yourself and I imagine this is not the only such case in which you struggle.
> The bus gets lighter and more efficient as it uses fuel.

This argument is weak. To get any kind of reasonable energy density you have to compress hydrogen to 10,000psi. The tanks to contain a gas at that pressure are heavy enough that the weight of gas inside is almost negligible. Especially in ground vehicles which aren't hugely sensitive to weight.
China had no intention to take over anywhere. They’re happy where they are.
> Somehow, with the most advanced computer and technological systems to ever be known by man, we're looking to increase working hours and cut benefits, for "profits" that are not quite realized by the labor class

Somehow?? This is capitalism 101. Not a "strange feudal state" nor anything else.
That exactly supports what I was saying. The definition change was a bureaucratic immune response, allowing plausible deniability around unfavorable comparisons.

If an everyman were to look at FRED and see an M1 hockey stick, he may reasonably think “look at all this money they’re printing!”

A fact checker would point out the everyman’s graph is misleading: it includes a definition change which inflates recent values.

But the money printing was actually unprecedented, and the fake graph told you more of the truth than the factcheck.
> Global security (lots of countries exist because of the US)

That's a very US-centric POV. It's not like half the world would suddenly cease existing if the US collapsed.
> It's worth remembering that the trolls that complain about Ruby do so because they care about it.

I don't think so. I mean there are complains about stuff you care about like people complaining about Healthcare. (edit: there are other forms of caring, see my grandchild comment)

Dissing on Ruby is definitely not this, they are not Ruby users wanting Ruby to be better. They don't even know Ruby apart from dissing on it is socially accepted, and makes them feel good.
> We’ve always been committed to providing a secure messaging experience

This is why iMessage is such a great experience on Android. They don't even try.
I am also retired and have more or less the same routine as you. I aim my own cooking time to a maximum of 7.5 minutes e.g. fried eggs and smoked salmon. I do open the door myself though. I hope you have an assistant because you can afford one and not because of some disability.
DigitalOcean perhaps? I've been using them for over 10 years and no trouble yet.

(I'm concerned they don't allow me to export the full server backups, but I backup the things I care about privately.)
What about when either changes? Do you expect them to alternate colour schemes as each protocol plays catch up or gets more features?
The last decades' worth of German administrations (and EU countries in general) removed nuclear on the promise of a cheap grid made from green hydrogen and renewables. What they delivered was a EU grid dependent on imported natural gas and a record high ~€400 billions energy subsidies.

It is hard to see whose promise of a bright future seems most realistic.
This is the kind of logic that stopped a lot of anti-gun lawsuits from taking place. All it takes is a shift in societal thinking for something like this to gain traction.
Mrs. Scyzoryk is a typographer, confirms that it’s not just math, but can’t imagine using ML for what is an integral part of developing an „eye” and going through the process.
Miro works great, I really like the UI
> A browser is an operating system feature.

Microsoft fought and (largely speaking) lost an entire case about that assertion [1].

[1]: https://en.wikipedia.org/wiki/United_States_v._Microsoft_Cor....
Enjoyed this - didn't realise how those codes were generated and could be done relatively easily
Now electric car transition there is done, too: they won't buy Teslas, but Chinese electric cars are banned, and European one are incredibly expensive, lose money to their makers, and just plain suck. All hope is for "european" cars made by Chinese brands that are "reassembled" (sometimes by doing as little as bolting the wheels on) from "kits" coming from China. Like Volvo. They are actually decent and may be better than Teslas.
While we are at this.. the real reason is that we have too many kids.
Sometimes later never comes, so it's a net win compared to languages where you are forced do this important work now.
No Silver Bullets: Why Understanding Software Cycle Time Is Messy, Not Magic
It's a bit of a stretch to say "refusing to give a country loans" is exploiting someone through debt. Though "refusing to roll over a loan" might count, if you have first made a country dependent.
I just eat when I get hungry and have the time. No effort to keep the same daily schedule. On most days I'll end up eating 4-6 hours after I wake up, but if I'm busy I have no problem toughing out a few hours of light hunger and eating closer to 10 hours into the day.

A 12 hour work schedule seems pretty difficult to square with this kind of eating habit, and I'd probably just switch to eating smaller amounts whenever I get the chance if I were in that situation. Do you find it particularly uncomfortable to eat multiple meals a day?
Show HN: I built TopicSimplify – Your AI buddy that organizes any topic
I got feedup scrolling through my chat and opening multipe tabs with chatgpt ,gemini, claude therefore I built a tool to help me study in an organize way.
Nothing is bullet proof, bad things can happen on Fediverse too. My point is that the Fediverse is much healthier in this regard.
Once you took a hard look at it you could tell that the injection molding was pretty low quality.

I also tested it. The cable was faulty and wasn't the HDMI standard we ordered.

Both are pretty good indicators that it's a counterfeit product.

Amazon co-mingles all their goods. So the likelihood of counterfeits, even in amazon basics products, is high.
This explains how elevators can always be hacked remotely by the Impossible Missions Force and other cinematic superteams.
end-to-end encrypted messagess, when the end-points (Android, iOS, Windows, etc) are basically spyware?

On top of that it runs through servers running who knows what, closed source stuff. So who knows if they're somehow decrypting everything on there before forwarding re-encrypted stuff?
Because tracking is inherently an anti democratic thing.

See pretty much every lesson in history ever, from the Schutzstaffel of the Nazis, to worker unions being doxxed, to lobbyism.

Our democracy relies on private information being secret, and any one sided party having that information is able to rule over the other.

There's a reason why Putin is so successful when utilizing his FSB and SVR apparatus.

The "i don't have anything to hide" reasoning is bullshit, because you didn't post your email addresses password publicly for everyone to see. Therefore, your reasoning is based on the assumption that you misinterpret what everyone vs some party you inherently trust means.

Look at US politics, where 50% of the population now regrets having shared their medical data with doctors, because the current administration decided to prosecute past visits to the gynecologist if a woman decided to not be pregnant. Something that was not illegal in the past is now illegal, therefore data in itself is incriminating by default.
For me this link results in a 503

I've read the gist of this article in my local news org feed. What it basically comes down to is that Finnish scientists noticed that Russian children who grew up in rural areas usually had way less asthma cases than Finnish city children, and thus began to research why this was the case. They hypothesized that early (first 10000 days) exposure to micro-organisms might play a key role in training the immune system not to over-react to (harmless) micro-organisms later on in life, and thus "train" the immune system better. Their hypothesis now seems to have been validated.

Basically this comes down to the hunch I had for quite a long time: Isolating children into an almost clinical environment is not a great way to boost the immune system. This might explain why there are so many people with allergies. People living too cleanly and not getting exposed to (benevolent) micro-organisms so that their immune system prepares them when exposed to later in life.
I think that's one of the reasons that kids that are around pets early in life usually have lower risk of developing allergies later on.

The reasoning went like this: We've spent most of our evolution in caves digging in dirt, and now (relatively) recently we have been transported into an environment where we can pretty much have the cleanest settings. What do you think this will do to our immune system?
https://github.com/ashinn/chibi-scheme
Thanks for your comment!

The official cloud hosted variant currently offers unlimited *@aliasvault.net addresses. However I’ll be adding more domains as time goes on as certain companies don’t always like the idea of aliases and tend to start blacklisting.

The self-hosted variant allows you to attach as many of your own domains that you want, and then you can choose which domain you want to generate an alias with from the GUI.

The ability to connect your own private domains to the cloud hosted variant is also on the roadmap and will be added in the coming 2-3 weeks. This will allow you to move from/to different services without losing access to your email aliases.
It's a bit unfortunate that the car manufacturers themselves still aren't making official battery replacement an option.
This is a salient point, I don't know how other countries handled it but American schools as an institution were absolutely wrecked by covid, a significant portion of the youths just straight up stopped attending school, and I'm in a bubble but most parents I know are homeschooling at least part time now, when they wouldn't think of doing so just 5 years ago

Does not bode well for the future of informed populi
> does this mean that the flow of traffic is constantly slowing down as it approaches intersections, even if the light is "green"?

Yes, if there's a sign before the intersection with a lower speed limit.

Say the road is a 90km/h road, there's an intersection and a 70km/h sign before it, you drive 70 through the intersection and 90 onwards (as it cancels the 70 sign).

It's there to prevent people from speeding through intersections and it is enforced in practice.
Time to add a leetcode medium problem for this.
Random three-body simulation generator
> 5) The chairman of JCB wrote to all his employees before the Brexit referendum to say how he was absolutely convinced it would be a brilliant success and would lead to great prosperity for Britain. So probably not the best people to take strategy advice from.

Thank you, a template ad hominem. I'll cut that out and put it in my scrap book
The article states that T-Online, a German news outlet, polled 100,000 readers, with 94% rejecting Tesla and only 3% considering a purchase. While the sample size is unusually large for a survey, the methodology isn’t detailed in the article. Online reader polls, like those often conducted by news sites, are typically self-selecting—participants choose to respond rather than being randomly sampled. This introduces significant bias, as those motivated to participate may already hold strong opinions, especially given Musk’s polarizing public image. Without information on how the survey was conducted (e.g., random sampling, controls for bias), its scientific validity is questionable.
It's not necessarily a roundabout, but it applies to roundabouts as well.
Just found out today that you can edit the page template in GoodNotes so that it's 5000pt x 5000pt, which is much, much larger than the default - at least for me that's close enough to having an infinite canvas
Centuries, not decades.
> Also Federal Reserve is not part of the US Government.

Well, they seem to get along pretty well in any case :).

They changed the m1 definition in the middle of the largest m1 increase in history. It messed up all the graphs and you couldn’t get a sense of the scale of the printing.
Chinese electric cars aren’t banned, they are tariffed
HN doesn’t have lots of simple features. I wouldn’t read too much into that.
Chrome was never about user agency though. The ideal Chrome is to be an un-configurable window to the Web, hence the name (it is the window chrome).
This idea of moral equivalence is popular and extremely dangerous. It is what Trump expressed as "you think we're so innocent?"

No countries are purely altruistic, but there is a big space between pure altruism and simply being exploitative. This ignores the role of norms in foreign policy. For example, think of how the US attitude to the Taliban was (and still is) conditioned by the differences in their beliefs about women in society.

If you think it doesn't matter whether America or China is in charge, you will be in for a shock. These countries have deeply different values, and their foreign policy will express that. I note also that you didn't mention Russia. I think it is obvious that Ukraine is not indifferent between being "exploited" by Russia and by the US.
Neptune: Recreation of the Cancelled Sega Console