skysight-inc/HackerNews huggingface dataset:
The terms were essentially redefined more strictly as our understanding of genetics grew more refined.

(I.e. per my sibling post, there were jargon terms with these names that had one particular definition under an early, black-box mental model of heritability that is no longer used/favored; and there are new replacement jargon terms with the same names, that have a different definition under the more-modern mental model of germline heritability.)

After all, there are entirely non-genetic mechanisms of heredity. You inherit some of your mother's immune histochemistry through developmental exposure, and more through consuming breastmilk. Yet there is nothing that "codes" for this histochemistry; it's just a stateful process (mother's immune system) interacting with another stateful process (foetal immune system) — working almost more like a "colonization" of commensal bacteria than like gene transfer.

In terms of "heritable traits" — "nature vs nurture" — such effects appear squarely on the "nature" side. But they're not germline heritable. Implant the fertilized egg into a surrogate mother, and you get different histochemistry. Have a wetnurse feed the baby, and you get different histochemistry.

If these things are "genetics" — if the information carried by the state of immune cells in response to observing natal antigens is "genes" — then the term "genetics" has no useful meaning / is useless to talk about the thing we want to talk about when we talk about genetics. Where "what we talk about when we talk about genetics", is how an organism's breeding/germline ancestry, predicts phenotypic outcomes.

And if you agree that that is the thing we want to talk about — then epigenetic information isn't "genes" (under the germline-heritability model) either. Your epigenetics is hereditary, but only in the same sense that your immunohistochemistry is hereditary — being passed via exposure in a natal environment, rather than being "written into" the fertilized egg.

(Also — at least AFAIK — we don't even consider our nuclear mitochondrial DNA to be a part of our genomes. Even though it is passed through the germline, and is intensely important in many congenital metabolic dysfunctions. Because our mitochondria are not technically "us" — we might call them organelles, but they're still more like commensal prokaryotes in how cells treat them: dividing on a separate timeline from our cells; not assortatively assigned to daughter cells by spindle fibers during mitosis; not observed + checkpointed to ensure sufficient numbers exist for daughter cells before telophase; etc.)
Surprised they didn't do a tattoo of an eye or something...
Comments belatedly moved to https://news.ycombinator.com/item?id=43185909.
but people who are depressed still improve when on SSRIs

Does that mean 'over 50%' of them improve, or is it, as is more common with pharmaceuticals, closer to a rounding error?

There was a deluge of media a couple decades ago about Prozac and its dramatic effects.

A few years later, I read some report that the studies testing its efficacy had ambiguous conclusions.
Ryzen 8000 was mostly mobile CPUs like the 8840U (there were a few desktop ones like the 8700G).

Ryzen 6000 series was all mobile.
We'll merge that one too. Thanks!
I worked at Best Buy as a high school teenager just before they switched the green screens to some GUI monstrosity. Everyone in the store had to learn how to use the green screens (sales people, cashiers, techs, stockers - everyone) and after a few weeks / months you would get CRAZY fast.

A few years later in college I worked there again and by that point they'd transitioned to a much slower GUI that basically just wrapped the underlying green screen system. The learning curve was slightly better, but it wasn't nearly as fast.

Purpose-built mainframe-based TUIs were amazing. We lost a lot in pursuit of colored pixels.
It's coming from elon, who has courted russia for Ukraine's metals and minerals since at least the 2022 invasion.
Comments moved to https://news.ycombinator.com/item?id=43185909.
Hugged to death for me right now, here's an archive link: https://web.archive.org/web/20250228192142/https://www.autod...
You are right. I do hope Zelenksy noticed the sudden caveats he added a few days ago, too. Same thing - Trump wants many billions in resources, yet "can't" guarantee anything in return.

Russia immediately responded by saying it would happily share those resources. Of course.
Exactly:

"I found the root cause and corrected it. It may be an issue in these other two places so we should check there as well."

"Great. How do we avoid issues like this in the future?"

"By doing X thing a different way, and ensuring that Y thing is also in place."
On the bright side, at least we'll be able to warm our hands by the waste heat of the GPUs.
Ukraine’s situation is better than many people realize, and the US, in siding with Russia, may be betting on the wrong horse.

The EU has provided more aid to Ukraine than the US, Ukraine drone production is through the roof. Europe needs Ukraine and its army as a bulwark against Russia.
If it comes to that, the current global society is done and gone, and quite possibly humanity with it. No way the UK doesn't have control over their own devices though.
I wonder how this surgery was originally 1) invented 2) proposed to colleagues.

"Hey peeps, I've been bouncing around this idea lately. So you know how Mrs Smith in room 230 has no eyesight left? Well one of her teeth came off when she fell last night, and I started thinking.."
Thanks! We ended up merging the earlier threads to https://news.ycombinator.com/item?id=43185909 since it had the original source and was posted first.
I've started going to the "new" section for HN instead of the front page to catch the news before it's flagged.
Also - there are people forced to use Edge ... Like me. To look at my payslips. Because InTune.

I use Firefox for everything else :)
Zelensky went there under the pretext of signing the mineral deal, but changed his mind before arriving.

He's trying to pressure Trump and America in general into giving Ukraine NATO membership or security guarantees against Russia.

Sorry, but Ukraine, which is not in NATO and thus not entitled to unconditional defense, is not worth starting WW3 over.

Its sickening watching Zelensky and Europe act like my country is obligated to go into unlimited debt or die on the battlefield to protect them.
We dropped plenty of bombs in unreachable parts of Afghanistan. Were those effective? Yes, they were

In the short term, yes. In the long term the US eventually gave up and left. Likewise, the US bombed Vietnam heavily, eventually gave up and left. You can't hold territory with bombs.

To say otherwise is to disregard history. To say otherwise is to place hope in pie-in-the-sky feelings and not the data we've accumulated over the last 200 years.

Every military historian will tell you the same thing I just did, and cite examples going back thousands of years - military arson serves the same function as bombing.
Show HN: I Built Hashtini – Turn Hashtags into Shareable Landing Pages
Hey HN,

I built Hashtini in my spare time to solve a problem my son, a YouTube creator, faced: sharing his channel offline with friends and schoolmates. He found it difficult to get people to visit his content when he couldn’t just drop a link in a chat. That got me thinking—what if there was a way to create a simple, memorable word-of-mouth tool for online and offline sharing?

Hashtags are easy to remember, so I built Hashtini as a way to turn hashtags into shareable landing pages, notes, and links. Instead of complicated URLs, creators can now use something like #MyBrand to direct people to their content from anywhere.

I iterated through multiple rounds of user interviews, refining the tool based on feedback from creators, educators, solopreneurs, and small businesses. To help users spread the word, I also set up a referral program that gives you $5 for each paid subscription you refer.

I’m sharing Hashtini here to get your feedback on how I can improve user acquisition and make this more valuable for the community. Would love to hear your thoughts!

Try it out: https://hashtini.com
We are one month into the Trump admin. I expect the economy will not do so well after the tariffs hit next week and several hundred thousand government employees are laid off. Oh, and I expect we might see further problems when people aren’t getting social security checks.
What's more embarrasing is that the only time article 5 was activated was for US when they got attacked on 9/11
Zelensky has nothing to lose at this point. If he takes the deal Trump proposed Ukraine will be paying the US and Russia for having been invaded in 2014 and again in 2022. And let’s not ignore the fact it was the US was propping up the politicians suggesting joining NATO and not renewing the lease on Sevastopol in 2015.
He made his priority pretty clear in that regard:

> Shortly before the meeting ended, Trump offered, “This is going to be great television.”

https://apnews.com/article/zelenskyy-security-guarantees-tru...
The site appears to be hugged to death for me.
If you have some tech skills and want something truly cheap, set it up directly with twillio, they have a basic scripting thing that can allow you to forward calls and such (chatgpt can help there) and the numbers are at something like a dollar a month iirc.
Claude Artifacts Games
Pay no attention to him, he's being belligerent in an attempt to atone for his sins of promoting liberal policies 12-16 year ago. His rants really don't represent anyone or matter in any way.
Canadian here.

If /r/conservative is not representative of conservative side of America, and the conservatives control the US Congress , I am puzzled that not one of the conservatives has pushed back on annexation of Canada or Greenland . Not One.
I think this is relevant and adjacent at least: https://open.substack.com/pub/ctsmyth/p/the-generative-ai-re...
Thanks—we've updated the title to mention licenses now. I think probably we'll end up merging all these threads; not sure yet.

Edit: merging into https://news.ycombinator.com/item?id=43185909.

Earlier thread (in this case) was https://news.ycombinator.com/item?id=43200065, which had that title.
Thanks I'm going to give it a read!

Off hand my first thoughts are (a) well it would make sense that the non-rapamycin-sensitive cancer cells would naturally be selected for - but that doesn't mean that your rates of cancer would be higher - and (b) how do you square this with the measured lower cancer rates in transplant patients on rapamycin?

My take, admittedly more research needed on my part, is that the cancer risk of anti rejection drugs is because the immune system would normally nuke some of these from orbit. However rapamycin works differently and doesn’t suppress the immune system so even with resistance developing the cancer risk would still be somewhere between lower and neutral.
This is “Irix” vs “Solaris” mode of counting, the latter being summed up to to 100% for all cores. I think the modern approach would be to see how much of its TDP budget the core is using.
Conservatives no longer exist. It’s MAGAs who replaced their made up god with Trump. Then there’s everyone else.
Doublethink at its finest.. We were always at war with Estasia after all..
Peace for Our Time, the sequel, by Trump and Vance.
Color wheels of the sort commonly presented in art books.
As a scientist, I like to believe that my greatest contribution is my fresh ideas. Maybe AI will be able to do this better than I can. If so, I'm not sure that I really want to be a scientist anymore. TBH, I'm in science because I enjoy the process of thinking, coming up with ideas and testing them. Eliminate any part and it just becomes another tedious job.
That's what I suspect as well, especially with the tesla bots, but there is also Ellison's influence
Sparsely populated areas? You mean the areas where we grow all our food? Yeah, we don’t need solid weather reports for areas like that.
Yes me too. Europe needs to get its act together and do _more_ but let’s also not adopt Trump’s descriptions of what has been given.

https://en.m.wikipedia.org/wiki/List_of_military_aid_to_Ukra...
Your beliefs do not give you the right to impose your beliefs' lifestyle restrictions on others, period.

Even if they did, forcing people through state violence to adhere to your lifestyle isn't very Christian of you.
This summer is going to be spicy. Just you wait.
It 100% looks like they were planning to force a confrontation. Notice how all the escalation is them, they start escalating over basically nothing, and they keep trying to crank up the temperature while Zelenskyy's keeping things nice and even. This didn't happen the last couple times world leaders made far more confrontational statements in a similar setting, but also Vance wasn't there to provide emotional support those times and, well, there are some common sayings about the actual nature of a bully.

I think Zelenskyy didn't give them the sound-bites or vibe they were looking for, but they're claiming some kind of victory (WTF) on social media anyway. Meanwhile all they managed to do was look some combination of stupid, childish, and traitorous, while he came out looking incredibly restrained, and overall more-articulate than them despite the handicap of speaking in English rather than his native tongue.
They used to have professionals managing such meetings.
A fairly surprising fact revealing how little we understand the efficiency of SSRIs is that the serotonin level rises pretty quickly once you have started taking an SSRI.

Still, there is an unexplained cascade of reactions that takes weeks before patients notice any improvement.

As much as I respect proof-based medicine, the very fact that scientists can't explain how all this works made me want to stop my treatment and just do more weightlifting and running.
Thank god that finally we're going to stop sending hundreds of thousands of men into a meat grinder for no purpose. Ofc, Trump is doing this in great part because he personally hates Zelensky and Biden. He's doing what he did to Obama and just unwinding everything his predecessor did. He also correctly ascertains that this is a huge waste of money that is counterproductive.

All the liberal cold warriors that wanted to bleed russia made Russia stronger by doing this. Not that I care either way, but it's funny to watch these war hawks have it blow up in their face, not that they really care since they are eating charcuterie at DC lawn parties with their Raytheon bucks.
I get what you’re saying, but Europe has its disgraces as well and I don’t see anyone rioting in the streets en masse. Don’t get me started on the UK, where core rights like freedom of speech/expression are a joke, yet I don’t see anyone rioting. I mean, maybe they ARE rioting, but any news about it being censored.
> Rioting in the US is viewed extremely unfavorably in the US

Unless storming the Capitol to disrupt a democratic election.
Putin said he would gladly share with the US. So there is yet another, larger carrot dangling in front of Trump's eyes.
Ubuntu Releases
I read /new more often than the main page nowadays (not just due to flags on political stories, but it does give a better picture of what's relevant rather than the survivorship bias of the front page)
No, this was shocking on multiple levels. What motivates the nominally most powerful person on the planet to behave like this?
Why China's Xiaomi Can Make an Electric Car and Apple Can't
Do you think any trump voters are changing their mind about him though? Are their conservatives that would vote against Trump right now if they could? I don't think so personally
More of the Ukraine conversation needs to be focused on this topic. The future of warfare is digital, automated, and utterly terrifying, and it's currently being shaped on the Ukrainian frontlines. Western militaries are going to be able to leapfrog their force structure based on the learnings in this war.

Ukraine is paying with their citizens lives for NATO to receive this education, while simultaneously weakening one of the western world's most dangerous geopolitical rivals. The fact that Americans can't see through the Fox News propaganda to understand this is unbelievable, embarrassing, and will set them back on the world stage for a generation or more.
It sounds like a very naïve explanation of depression. I'm cynical enough to believe that's why it's popular:

"You are sad because you are missing happy chemicals"

Reality is more complex, hitchen's razor tells us we don't need to spend more time down that road.

That said, I'm open to the idea that ssri's (while certainly tangential to the theory) are more complex. If only because they may be prescribed early on either due to a physician desire for a simple theory or due to the patient's desire for it. But once you have gone down that road you can't change course easily.

I believe whatever issue existed prior to SSRI onset becomes secondary (whether for better or worse) to the symptomps caused by SSRIs themselves, the patient becomes fungible and the disease a categorizable syndrome with clear treatment and support systems (and low suicide rates, which is usually the concern of family).

On that note, the medication is not only taken for the patient, but some properties are designed/selected for the physician (low suicide/malpractice rates) and family (less outwardly symptons). In this way it's a milder version of lobotomies to my judgement.

End rant
This is really sad
Free, and owned by a cult!

https://en.wikipedia.org/wiki/Unification_Church
I use Arc for work. It has a few nice UX enhancements. None of those things that you mentioned affect me on a day to day basis. (Honestly, I don’t pay attention to marketing when making my decisions.)

Pretentious or not, Arc is pre-enshittification. Chrome, Edge and FF are not, which is what matters.
As a European, I’m disgusted—not just by your leadership, but by your silence.

I'm quite pleased with everything that's going on. The lesson from Korea, Vietnam, Afghanistan (Soviets), Afghanistan (US), and Iraq is that there is never going to be a good time to leave but you need to leave as soon as possible before things get worse.

There's the counterargument that Hitler could have been stopped early during/after Czechoslovakia but you can't waltz into every conflict just because it might turn into WW2 later.
https://mullvad.net/en/help/dns-over-https-and-dns-over-tls#...

Not exactly the simplest instructions, to your point, but you can still just do it once for them or get on a call and walk them through it. They might even notice that websites load faster when they don't make dozens of requests to advertisers and trackers.
Notorious Malware, Spam Host "Prospero" Moves to Kaspersky Lab
Negotiations get heated. It's the only way to reach an honest agreement. Better to get those feelings out.

Trump was elected on negotiating a peace, and that's going to piss off Zelensky. Zelensky became entitled to a blank check with no strings attached. Now the terms have changed.

There are some people who expect dialog to proceed like an HR meeting, and those that find relief in direct and sometimes heated language.

To me the meeting felt like a tremendous relief. A resolution will develop, finally.
NASA sends experiment to space to study antibiotic-resistant bacteria
nope, they can do a deal with the Russians.
If you haven’t refactored most of your code more than once, you are doing it wrong.
I do wish these were easier to integrate with prometheus or graphite. They both have rudimentary forecasting models but both leave much to be desired in parameterization.
You're right, and at the same time those two things go together if you think about it. The browser that does more (or cares at all) is held to the higher standard and inevitably found wanting.

(I'm not taking sides in the debate about it, I just find internet psychology fascinating)
Yes, Zelensky just called Trump's bluff more or less.
What Would a Martian Calendar Would Look Like?
They're covering their asses for something. That could also just mean that the old license/terms/privacy policy doesn't actually cover the data processing they're already doing (i.e. the opt-out telemetry, the account sync mechanism, etc.). If they publicly admit that their previous agreements didn't provide enough legal cover to allow their basic data processing, the class action lawsuit vultures would be all over them.

Something something malice something incompetence.
The US military was concerned about this scenario long before and raised concerns back in 2011. They predicted why someone like Trump would would come in power and question the purpose of NATO. But it was not taken seriously by NATO allies at that time. Obama even wanted European allies to be able to launch their own military missions with just US as a support role. The Libya interventions was supposed to be a test of that.

https://www.atlanticcouncil.org/blogs/natosource/text-of-spe...
Can you tell me where it referenced it as a theory outside of the headline? It also concluded that there is a lack of evidence for the association so why would the authors call it a theory?
This is a very shallow take
The US is trying to kick Canada [1] and the UK [2] out. If the US is going rouge, the rest of the free world can go without them.

[1] https://news.ycombinator.com/item?id=43200375

[2] https://news.ycombinator.com/item?id=43166670
People fighting despots for their people's freedom should be welcomed and supported, not made to beg.
Public humiliation of an ally in distress.
It looks like Deepseek will probably be able to do this for a fraction of the cost.

It's a matter of time for someone to roll out an open source version of the cli coder tool that lets me pick a cheaper LLM.

I like the tool, but it makes so many tiny mistakes I wouldn't trust it at work.
It feels like Vance is playing the part of Edith Bolling Galt Wilson in protecting Trump from the 25th amendment (then Article II), but he absolutely sucks at it.
If the Vice Presidency is vacant, the President nominates and Congress (both houses) confirm.

> Whenever there is a vacancy in the office of the Vice President, the President shall nominate a Vice President who shall take office upon confirmation by a majority vote of both Houses of Congress.

25th Amendment

https://www.law.cornell.edu/constitution/amendmentxxv

The VP can be removed by Congress (impeachment), the President cannot direct the VP to vacate the office.
The US has an effective way of ending that: more, heavier weapons, no restrictions, and a promise to place peace keepers. Instead, they chose to infuriate a key player. Cui bono?
whatever you think of Ukraine or Russia, inviting an elected official of a nation under war then spouting off Russian propaganda and berating him in public is shameful. I don't think we've ever seen such non-diplomatic language and grandstanding in the oval office before, in this century at least.

Zelensky was invited to get fox news soundbites of Trump and Vance beating up on him. That's it. a sad state of affairs and a scathing indictment about how uneducated the maga base is around world affairs.
The problem is that ‘anonymized data’ is quite a big spectrum, and may be able to be deanonymized quite easily.

See this submission from earlier this month: Everyone knows your location: tracking myself down through in-app ads (26 days ago, 1957 points) – https://news.ycombinator.com/item?id=42909921
Humiliating people does appear to be a common theme with the administration, one just has to look at the photo they put out after winning with RFK and the McDonald's takeout on airforce one. Also all the women jockeying for various positions getting plastic surgery, looking like an army of botox'd stepford wives. I'm no armchair psychoanalyst so I can't tell you what it means. Just that it's very.. apparent and intentional.
Trump administration retreats in fight against Russian cyber threats
Look like it worked.