skysight-inc/HackerNews huggingface dataset:
SSRIs aren’t shown to be much better than placebo and are shown to be about as effective as therapy — which is actually durable.

There’s also rates of sexual side effects in excess of 70% [1] and they cause weight gain which is separately associated with depression.

In fact industry data shows a smaller gap between SSRIs and placebo than FDA data. See Figure 1. [2]

The problem with SSRIs is that serotonin receptors are all over the body including in the gonads and they play a large role in appetite regulation.

They do something but it’s not nearly what people assume.

[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC6007725/

[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC4592645/
What's really infuriating to me is the way in which members of the startup world -- people who claim to wear the mantle of creators and builders -- have actively supported this nonsense. A16Z, Founders Fund, Sequoia all talk a big game about America being the greatest nation on the planet, and then turn around and back this regime in a naked grab for power and money. The hypocrisy is astounding.
We need continuous self learning and improvement at the level of post-training weight updates.

My endeavors in this area show that it is very difficult for an LLM to build up and integrate novel knowledge through conversation. Any new developments that aren't in context, are completely forgotten unless they are continuously kept in context, along with enough reassuring text that the novel knowledge is accurate if it goes against the LLM's training.

Is there any research into 1B-2B sized models that can be continuously finetuned on RTX 3090?
Personally, I've found computer writing is perfectly fine for note taking; but, once I actually want to compose something that I've really thought through, I'll turn to handwriting for complete sentences.

I think the internet generally makes way too much out of which tool you use. Use whatever works for you and what allows you to do it consistently.
Show HN: Betting game puzzle (Hamming neighbor sum in linear time)
In Spain, there's a betting game called La Quiniela: https://es.wikipedia.org/wiki/La_Quiniela_(Espa%C3%B1a)

Players predict the outcome of 14 football matches (home win, draw, away win). You win money if you get at least 10 correct, and the prize amount depends on the number of winners. Since all bets are public, the number of winners and the corresponding payouts can be estimated for each of the 3^14 possible outcomes. We can also estimate their probabilities using bookmaker odds, allowing us to compute the expected value for each prediction.

As a side project, I wanted to analyze this, but ran into a computational bottleneck: to evaluate a prediction, I had to sum the values of all its Hamming neighbors up to distance 4. That’s nearly 20,000 neighbors per prediction (1+28+364+2912+16016=19321):

S_naive = sum from k=0 to r of [(d! / ((d-k)! * k!)) * (q-1)^k]
(d=14, q=3, r=4)

This took days to run in my first implementation. Optimizing and doing it with matrices brought it down to 20 minutes—still too slow (im running it in GAS with 6 minutes limit). For a while, I used a heuristic: start from a random prediction, check its 28 nearest neighbors, move to the highest-value one, and repeat until no improvement is possible within distance 3. It worked surprisingly well.

But I kept thinking about how to solve the problem properly. Eventually, I realized that partial sums could be accumulated efficiently by exploiting overlaps: if two predictions A and B share neighbors, their shared neighbors can be computed once and reused. This is achieved through a basic transformation that I implemented using reshape, roll, and flatten (it is probably not the most efficient implementation but it is the clearest), which realigns the matrix by applying an offset in dimension i. This transformation has two key properties that enable reducing the number of summations from 19,321 to just 101:

- T(T(space, d1), d2) = T(T(space, d2), d1)

- T(space1, d) + T(space2, d) = T(space1+space2, d)

Number of sums would be the result of this expression:

S_PSA = 1 + (d - (r-1)/2) * r * (q-1)

I've generalized the algorithm for any number of dimensions, elements per dimension, and summation radius. The implementation is in pure NumPy. I have uploaded the code to colab, github and an explanation in my blog.

Apparently, this falls under Hamming neighbor summation, but I haven't found similar approaches elsewhere (maybe I'm searching poorly). If you know or you've worked on something similar, I'd love to hear your thoughts!

colab: https://colab.research.google.com/drive/1aENKd7eemGqmjdB8Y6y...

github: https://github.com/petopello/PSA

blog: https://sudapollismo.substack.com/p/partial-sum-accumulation...
The "certain segment of his supporter base" is now completely managed by Russians in their information / cognitive domain.
Listen to their state media
The EU was united, namely in not bothering to help Ukraine. The US decided to want to help Ukraine and send weapons and set the tone and (slow) pace of the weapons that they sent. Only for them to pull the rug away later anyway. This is really terrible leadership, leaders who don't care about the results that they cause are poison. You can argue all day that it's sad and terrible that the EU wouldn't have helped at all. But under Germany's leadership at least this farce wouldn't have played out. You can argue then that it might cause problems later because Russia would be emboldened by a quick win in Ukraine. Fine but this is better now?
Zelensky needs to step down for the sake of Ukraine and its people. He fails to grasp a critical reality: criticizing Trump is a mistake. Instead, he should focus on praising him—highlighting his intelligence, leadership, and appeal. More importantly, he must recognize that Ukraine’s survival depends on continued US support. Without the US, the country risks ceasing to exist.
Communicating is hard, this is intended to be helpful and informative and I genuinely hope you take it that way. I'm being a little barbed with some of my feedback below, because you're engaging defensively, and I'm just trying to help because I was initially interested in having a different conversation with you based on your first comment.

Really importantly, I'm not saying that you're lying. I was offering some constructive feedback on what you said, because I was interested in your experience given that you've clearly reached a different conclusion from me. I was disappointed you weren't willing to talk about it, because I suspect if you're experiencing this and this is your advice you're just earlier in the process than I am. But if this isn't the case, I (and others clearly) were interested in this experience. I don't have a solution to this problem, and I came to this article looking for other ways people were navigating this experience.

> Just sharing my experience.

But you're explicitly not sharing your experience. You're just saying that you have experience, and then asking why someone would make a decision in this situation. In my response, I can either talk to:

1. Why someone would make a decision in this situation

2. You about your experience.

If you don't have experience in the situation, #1 makes more sense. If you do have experience in the situation, then I'm much more interested in the #2 conversation but to do that we have to be a little bit more willing to share some broad strokes about how things have fallen apart.

I shared my situation in response to this without making anything too personal/revealing about the family members involved. You'll notice I didn't make an appeal to having personal experience. I just described the experience, because I'm looking to have a conversation about what others have tried that has worked for them.

> The person I was replying to did exactly the same thing: "Without going too deeply, I sympathize with the writer on an extremely personal level."

2 things:

1. This is the age-old "if people on the internet jump off a bridge you'd do that too?" My initial response was trying to give you the tools to be better at this, and you're just being defensive here for no reason. I thought your question was still worth responding too, I'm just calling out to you that it's stronger without the appeal to experience that you're not backing up in any way.

2. This is a disclaimer on their own partiality towards one party in the original story. This is actually achieving the exact opposite of what your comment goes towards. It reads much more as "I am stating my bias and what I'm partial towards up front, but I think there is a difficult choice to make here and I'm not certain what the right path is."

By contrast your statements taken together read as "I have experience that tells me there's no reason to ever sever a relationship and you just have to take me at my word." But your initial statement could have been "Why would you consider severing the relationship?" and it would've led to less confusion from people interested in the experience.
Okay, in that case I do think one of the data-holding types in rust is a fair comparison, adding some runtime checks to let you be looser about ownership. Then you can write a function to split/share an array without a single bit of unsafe code.
bad choice of words from me indeed. What I wanted to say is that a lot of people, especially in the Eastern Europe look at the US as a rock solid partner - even more solid than EU. That dates back to WWII.

Its time to change that perception.
The culture dies if locals don't have children and the immigrants don't assimilate. There are already many pockets of micro cultures in the US and that's what the people in power are using to divide us already.

I'm increasingly convinced that the goal is to balkanize the US and establish a Network State guided by silicon valley, as described by Curtis Yarvin
https://apnews.com/article/doge-federal-contracts-canceled-m...
Absolutely an unimaginative & incorrect take and here's why:

1. The entire affair provides cover for continued operations against Russia without great power escalation. Hopefully Putin doubles down and loses even more military assets. If you don't understand this point take a day or two to think it through.

2. Ukraine cannot win (its objectives) this war without Western troops at some point & that's been clear since the start. US objectives have been met, with Russia unable to mount a conventional threat to Europe; with its hardware now discredited against Western weapons - much to the dismay of the Sino-Russia-Iranian axis; and with European underspending on defense & overreliance on Russian energy now reversing.

3. Get used to the new USA. We are going to very publicly assert our power and by doing so hopefully deter war in Asia.

Anyone who doesn't understand 1-3 needs to meditate on this and grow a pair.
Greenland is worthless, and having a long running territorial dispute with the entirety of Europe would be bad for all involved.
The Propaganda Minister is also decrying Zelenskyy on Twitter, on cue. Probably had the tweet written hours ago.
'I don't really care what happens to Ukraine, one way or the other'

- J. D. Vance - podcast interview 2022
Sounds like when Jon Stewart went on Crossfire and destroyed Tucker Carlson who had attempted to escalate and get angry. And Jon was like "this is theater."
Ghostery is the thing you want to block in the first place.

https://web.archive.org/web/20130619042941/https://www.techn...

I see tracking consent opt-outs as pointless and misleading at best because the adtech industry doesn't operate in good faith. Just block them.
State Department terminates U.S. Aid in Ukraine energy grid restoration
Which ones? You'll have to be more specific.
You can criticise the government in any way you like

You can't incite violence - and if you do that when there's a riot ongoing, the punishment has resulted in jail time. Anything nazi related is also a no-go
Are you calling for armed conflict between nuclear powers ?
Previous discussion: https://news.ycombinator.com/item?id=43102528
That was the most shameful thing I’ve ever seen as an American.

Where is Congress? This needs to stop; impeach Trump already!
It was content for a segment of his base.

On Twitter, it's common to find populist-right commentators say things like:

1. Supporting Ukraine against Russia is risking WW3

2. Zelensky is always asking for more, more more and is SO disrespectful to the generous United States. And he doesn't even show up in a suit when meeting the president. How disgraceful. etc. etc.

These points were both touched upon by the Trump/Vance tag team and that's no coincidence.

My respect for Zelensky, the only decent politician in that room. Ukraine is lucky to have him in a time like this.
If Europe's military were so strong, why does the US need any involvement?

There's a reason even Zelensky described the EU militaries as weak, and believes a European army to be necessary.

Don't confuse spending with strength either: The UK, on paper, spends 2.3% of GDP on the military. That sounds good - until you realize they have only 136,000 personnel total. That's not going to defend the UK from anything - it can't even defend Ukraine for a year.
This is what a falling empire looks like. America First is a project to dismantle the U.S. empire and reduce it to just another country.
For C++, abseil’s thread annotations are quite nice for getting closer to the Rust style of locking. Of course, the Rust style is still much easier to understand and less manual.
How long are we going to try to cook this nothingburger?
Yarvin has stated he absolutely is not the person on top. That he’s not cut out to be that person. His role is the philosopher; more a priest than prince.
Like Gaza for the development of Kushner's hotels on the seaside.

And I bet the right-wing-conservative scum helping him from Israel already got their shares.
if Ukraine wants to end the war they need to defeat Putin
if Russia wants to end the war they need to leave

why are you blaming Ukraine
> It represents the interests of the American people who voted for Trump

It really doesn't and they'll come to feel it even if they don't recognize it.
I think it's actually Thiel who is in control and pulling the strings here. He essentially got Vance into his current position and is obviously still linked to Musk.
A quick ramp-up on ramping up quickly in SpiderMonkey
Watching Netflix shows is a horrible way of learning about nuances of international conflicts.
Like a misbehaving child called into the principal’s office
Imagine you have a depression inventory (test) with 21 questions, rated from 0-3. The highest score is 3 * 21 = 63 indicating the most severe depression. The lowest score is 0, indicating no depressive symptoms at all.

In practice, the average person will fall more in the range of maybe 5-15 due to vague symptoms like "I don't sleep as well as I used to" triggering some of the points. The average depressed person who seeks treatment might fall in the range of 25-35.

Now imagine the placebo group goes in with an average score of 35 and improves to a score of 25 by the end of the test. The SSRI group improves to an average of 20 by the end of the test. Is this significant? Well, it depends on how many patients you have in the sample size.

That's the problem. There's only so much room in these scales for improvement, so when both groups improve a lot you need to have a larger sample size to get statistical significance. Getting a lot of patients in a study (hundreds) is very expensive, so it's only a small number of studies that can pull this off.
This is because Microsoft Edge is embedded deeply into the Windows operating system, with no way to remove it.

On Linux, you typically can install whatever browser and uninstall the default one that came with the OS if you want.
They know how to send cake at least
Getting everything they want? Go do some research on what this has cost Russia - its the biggest catastrophe for Russia, possibly ever. They will never recover due to demographic & energy realignment pressure. Try to think ahead.
There's a difference between "siding with Russia" and siding with negotiated peace.

Many people seem to think that the US, and to a lesser extent the EU, should fund this war indefinitely. However, the US clearly does not benefit from a direct war with Russia, and while we may gain from a proxy war, choosing not to fund it does not equate to “siding with Russia.”
In the longer term there's realistically no chance of Ukraine regaining the land it lost. In both this scenario and that scenario Russia annexes part of Eastern Ukraine, but in that scenario there aren't hundreds of thousands of dead Ukrainians.
Thorium (https://thorium.rocks/) is a fork of Chromium that maintains a patchset that reverses functional and UI regressions introduced by Google (such as the tabs and menu styling from the 2023 refresh). The author has committed to maintain manifest V2 support for as long as possible.
I am not saying that quitting SSRIs is the ultimate answer, it just works (sort of) for me mostly because I am not that depressed.

Also, having partial theories is not wrong, but in the case of SSRIs, I deliberately chose to avoid medications that I can do without (again, this is highly subjective).

Another concern of mine is that there are now warnings for some popular SSRIs that ED symptoms in men might be permanent.
> You have moved the goal posts from "precisely 0" to probably too late.

For all practical purposes, if you're not an insider, the timing of "probably too late" coincides with "precisely 0" and the availability of the memecoin for retail purchase.

> Also, lol at the reddit OP "I'm not the bagholder. I'm significantly in profit and want to take it. Any advice on the most cost effective way?"

I don't laugh at that person, because I don't know their circumstances. It's sad to see someone defrauded, regardless of what you or I might think about their level of knowledge.

Similarly, I also don't laugh at cash strapped fixed income seniors who fell for fraudulent financial products. The reason for regulation (and government departments like CFPB) is to protect such people from fraudsters.
This applies to PDFs with lots of text. The smaller the text on the page, the more impacted it is.
I don't recall the original version we used unfortunately :(

in our case, the bump was actually from gpt-4-vision to gpt-4o (the use case required image interpretation)

It got measurably better at both image cases and text-only cases
WSJ: 'Inside DOGE's Clash with the Federal Workforce'
Who is going to disqualify him? Republicans would just invent some doublethink for why it is okay for this particular African to have that role. The extremely partisan SCOTUS will allow it, and that will be that.
Surely that points towards Russia? What are you suggesting?
"The main areas of serotonin research provide no consistent evidence of there being an association between serotonin and depression, and no support for the hypothesis that depression is caused by lowered serotonin activity or concentrations."

I wouldn't call it a theory especially if you're being semantic about serotonin reuptuke. Perhaps it's you who is using words you don't understand?
Unfortunately, Skype was an easy way for people to easily call toll-free US and Canadian numbers while overseas for free.

(E.g. need to call an American airline or rental car company while abroad).

Sometimes the local numbers would cost you money to call (or were only available during business hours and in the middle of the night for you, it may be daytime hours in North America).
or of a CERN experiment in ~2015 having had ...side effects
The betrayal of Ukraine by the American people will be a stain on their history forever. Americans just don’t really understand what is happening.
How would you categorize Russia's manpower problem, given that they need to rely on North Korea for people, have to send injured soldiers back to the front line, and suffer multiple more deaths and injuries compared to Ukraine?
Development of Robotic Device That Performs Head Bunting to Relieve User Tension
> But what Trump is betting on is that it could be the US + EU + Russia vs China.

This makes no sense when put up against reality. The US is alienating the EU, throwing Ukraine under the bus, alienating NATO (major military alliance) and Five Eyes (major intelligence alliance) just so they can bring Russia in to the fold with the US and EU? How, the US won't be partnered with the EU at this rate.
I have found myself to be someone that loves learning a little bit about various tech disciplines, but I've ended up as a "master of none" because I get bored quickly. Any advice for a career path that would reward such a thing?
well, after all we've been through together, i expect the french might find the opportunity for us to "owe them one, publicly" quite irresistible...

(which is significant because, "after all they went through the last few times", their "find out" policy is a little punchier than most)

and i don't think that anyone really wants that course of events...
Yes, sorry. I have scaled up my hosting and it's back :)
> "just remember to take and release locks"

If only it were so easy.
Sorry for not mentioning you initially and thank you Sir for making it happen!

I obviously love classical RTS and playing them since original C&C, but there are special place in my heart for Generals exactly because ot was different game.

And for me as game developer seeing this game in a sad state make me sad. I feel it does have as much potential as AoE2 and now more people can try to bring new life to it.
I think Europe will see this as a clear sign that Trump just attacked one of their own. I would not be surprised if the EU nations soon call a conclave to discuss establishing a new compact for self defense (and economic interest) that EXCLUDES the US. If this does come to pass, then yes, Trump and all of America will have lost.

This bright shining revelation of just how ugly and stupid Trumpism truly is (and America, by proxy) may realign world powers for decades, to our great loss.
Can you please inform me how the US bullied UK into mineral rights in WW2? We exported arms and equipment to them even before Lend-lease acts.

It would be true if you were to mention about our special flavor of freedom exportation during the cold war. However, this time Ukraine is a democratic nation being invaded by our biggest political rival, Russia.
Quick summary: https://www.lemonde.fr/en/about-us/article/2025/02/26/in-the...
While being smarter than Trump is a very low bar to take, Putin and Dugin are not the sharpest pencils in the box either.

Smart people are often beaten into submission by bullies. Being smart is not everything there is.
I solved the task with Claude 3.7 and got rejected by an AI startup
I was interviewing for a senior software engineering role at a startup. They assigned a take-home algorithmic problem with a presentation, estimating about half a day of work.

For clarity: no restrictions were placed on tools, only on the deliverables. In previous technical interviews with other companies, I'd openly used AI—even running ChatGPT during live calls with engineers. Everyone seemed genuinely intrigued by this approach.

Could I have solved it manually? Certainly. Research the problem, internalize the domain knowledge, prepare the presentation... a few hours of work.

Or I could collaborate with Claude 3.7 and finish in ~30 minutes through quick iterations, including the presentation, a quick summary of the solution, and speaker notes. I chose the latter path.

They rejected me because of this.

The irony? This was an AI startup.
Post specific or shut up, because this is just spewing bullshit with some true bits sprinkled on top for the sake of deniability.
I worry they don’t need wwii levels.
Would you like to wager against JD Vance lasting the entire term?