skysight-inc/HackerNews huggingface dataset:
For reference, the title of the paper this appeared in is "Novel RNA- and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity"

Google Scholar reports 43 citations: https://scholar.google.com/scholar?q=Novel+RNA-and+FMRP-bind...

The images still seem to be visible in both PubMed and Nature versions.

PubMed version: https://pubmed.ncbi.nlm.nih.gov/26586091/

Nature version: https://www.nature.com/articles/ncomms9888

Nature version (PDF): https://www.nature.com/articles/ncomms9888.pdf
This is still pretty true. The xenophobia is waning as Japan's economy stagnates and there's a general vibe that Japan did something wrong economically. But otherwise, these all continue to be real issues in Japan.

These days there's also huge problems with infidelity, marriage rates, and divorce.
I wanted to hire a personal trainer who just couldnt coordinate a call with me and I asked him to send me the details per mail. They said they dont do emails so didnt choose them as it was to scammy for me
> I don't dislike calls, I just hate time wasting. And some e-mail threads should have been a call.

I like to think I can "read the room". I particularly try to send email, versus a call, when the recipient will need to take time to prepare a thoughtful reply.

I've had several calls, sparked after a detailed email, where I end up reading my message literally word-for-word only to be met with the response: "Yeah-- we I'll need to respond to that offline".

Just. Read. My. Damned. Email.

I think very little of people who won't take the time to read anything longer than a couple sentences. It's especially galling because I work hard to write terse, bottom-line-up-front style-emails.

Hot take: W/ LLMs being used to summarize text, and robust text-to-speech, maybe I won't have as time-wasting calls. The kind of person who can't be bothered to read probably likes those kinds of things.
Gonna look into these, thanks for sharing!
That assumes children don't use "free" VPN sites/extensions.
Oooh I am working on a brand new Django based project, thanks for this!
You cannot seriously think that Hamas did not try to kill people on Oct 7th. Flagged.
Or from my own experience, suddenly realize you forgot to make a picture of the gel (or lost it?) and all you have are the shitty ones.
“Through-running involves operating trains across Manhattan and through to the other side of the city, instead of immediately turning them back to the suburb they came from, as is done today.”
Edit: making clearer, including text from the law.

You inadvertently highlight one of the main issues with the GDPR: unclear guidance.

From the "Does the GDPR apply to companies outside of the EU?" page at gdpr.eu:

"If your organization uses web tools that allow you to track cookies or the IP addresses of people who visit your website from EU countries, then you fall under the scope of the GDPR. Practically speaking, it’s unclear how strictly this provision will be interpreted or how brazenly it will be enforced. Suppose you run a golf course in Manitoba focused exclusively on your local area, but sometimes people in France stumble across your site. Would you find yourself in the crosshairs of European regulators? It’s not likely. But technically you could be held accountable for tracking these data."

Even their explanation is not clear. Notably, it's different from your understanding of whether it would apply. Which: I don't blame you, the law is not explained well anywhere I have seen. And their conclusion of "Not likely. But technically..." is not sufficient as official guidance.

What if we go to the law itself?

"
2. This Regulation applies to the processing of personal data of data subjects who are in the Union by a controller or processor not established in the Union, where the processing activities are related to:
(a)
the offering of goods or services, irrespective of whether a payment of the data subject is required, to such data subjects in the Union; or
(b)
the monitoring of their behaviour as far as their behaviour takes place within the Union.
"

Section b doesn't have the carveouts you asserted. Is that exemption in one of the other 98 articles, or an amendment, or elsewhere? Or does it not formally exist?

If the hypothetical US ski resort uses e.g. Stripe that allows people to pay in whatever payment mechanisms are common in their countries, does that alone mean I am "targeting" EU residents? What if my billing page allows a customer to select Belgium in the billing address? What if I don't block shipping addresses in the EU?

The intent here is not to litigate this to death, but rather to point out that the reason so much of the understanding of the law is contradictory is that the thing itself is complex. People don't want to get sanctioned, and putting cookie banners on sites is a way to prevent sanctions.
Ask HN: What is your default notes app?
I'm a google notes guy, but not particularly fan of it, I've tried out Samsung notes, apple notes, and few other android note taking apps.

Hell, I even built one as a 17 y/o kid here https://play.google.com/store/apps/details?id=com.cloudx.notes
but I've always wondered, what makes a notes app that can replace simple pen and paper, I know a simple app can't do that at least. I decided to rebuild it from scratch, one especially designed for the thinkers, developers, founders and engineers. Those who have the most on their mind but often fail at organizing the info.

So, I'd like to know your perspective on a few questions

1. What is your notes app? and Why?

2. Do you still often find yourself using pen and paper?

3. What is your primary(and tested) setup for productivity?

4. Do you like to have things like tasks, broken down or as a singular big task?

5. How much of your notes originate from research on the web?
> Our apps are blazing fast (<500ms screen loads)

I’m not sure I would consider 0.5 seconds to be blazing fast.

I wish the article went into detail on what these screens do and what a screen load means exactly.
Basically this. The people running the show would desperately like to make it simpler, but ultimately it’s left overly complicated due to priorities from past leadership well above our paygrade.

The right solution is always to just rip off the bandaid and do it again by hand in a new language or platform, and to eliminate useless complexity while doing so. Unfortunately no leader would ever do this because the Board and/or Shareholders would crucify them for not outsourcing it to McKinsey first and using the fancy-pants automation tool their report recommended.
It’s for people who play Nintendo games first of all.
Other people don't have their heads in the sand and understand exactly what the incoming administration sets out to do, as they have been quite vocal about it.

Yes, the last several presidents have also worked to weaken our democracy, but this time the effort is much more concerted among the administration, and detractors will be removed from their posts.

It's not dramatic to be concerned with the health of our democracy or to recognize clear assaults on it.
> but the Haber process could equally well use hydrogen made from water electrolysis using solar/wind energy.

You can also use methane pyrolysis, which outputs solid carbon instead of CO2. It's supposed to be somewhere in the middle of cost between steam methane reforming and water electrolysis.
I agree with most of the other comments here, and it sounds like Shopify made sound tradeoffs for their business. I'm sure the people who use Shopify's apps are able to accomplish the tasks they need to.

But as a user of computers and occasional native mobile app developer, hearing "<500ms screen load times" stated as a win is very disappointing. Having your app burn battery for half a second doing absolutely nothing is bad UX. That kind of latency does have a meaningful effect on productivity for a heavy user.

Besides that, having done a serious evaluation of whether to migrate a pair of native apps supported by multi-person engineering teams to RN, I think this is a very level-headed take on how to make such a migration work in practice. If you're going to take this path, this is the way to do it. I just hope that people choose targets closer to 100ms.
https://archive.is/hSIRn
I mean, the extended headline suggests it is producing fuel, which is wrong.
>Where you touch it when not in use doesn't matter.

Being able to easily grab something is always important, especially anything portable. I'm going to pull it out of a bag, move it across a table, etc. and having microbezels gets in the way of that by reducing the useful grabbing space.

Smartphones are the epitome of horrible here. With silky smooth glass and/or sheer aluminum/plastic on all sides with nanobezels (or no bezels at all...) and razor thin thickness, they are a fucking pain to grab and handle without dropping them. Most of us put them into a case to give them the necessary girth and friction for practical handling.

Mobile device design and design in general nowadays focus on aesthetics way too much to the detriment of practicality. People handle and use them at the end of the day, they aren't for oogling.
Having recently ridden Amtrak, easily the worst thing about it is the fact that they've decided to go with an airline style boarding process where the platforms are treated as a secure area and everybody has to single-file get their ticket checked to get onto a platform.

The whole advantage of a train vs a plane is that a train has many doors, allowing a lot of simultaneous boarding to happen; and they also already have conductors who check your ticket to make sure you are getting into the correct car, and another ticket check once the train is in motion. It would be significantly better at major stations to just have conductors at every train car on the platform in parallel doing ticket checks, rather than just have one funnel.
Of course they do, because it doesn't. Democracy dies in broad daylight. It takes a bullet in the head like a mob hit in the center of town, and no one sees a damn thing.
Recall effort against Newsom underway in CA after mishandling of LA fires [video]
I use this method with X. I only follow a few accounts and exclusively use the following view (which prevents algorithmic content push).

The drawback is that it can become monotonous. However, there’s the “For You” view and the curated news section to mitigate this.
I find it interesting how much Ebert hated that movie. I'm not sure how I feel about it myself, tbh, but I am certain I don't have his conviction to state it clearly and unambiguously. The film certainly made me feel things no other movie has.
The "move a branch from one commit to another without changing anything" command is "git reset".

"git reset --hard" is "...and also change all the files in the working directory to match the new branch commit".

"git reset --soft" is "...but leave the working directory alone".
"I discovered that if one looks a little closer at this beautiful world, there are always red ants underneath." -- Well, he ain't just talking about literal ants...
Yes for me it's a tie between Mulholland Drive and Lost Highway. I also prefer Mulholland drive.

The news makes me sad, I feel like I've lost a friend, even though I never met Lynch.
For private repos, Github runners are slow and overpriced. We switched to buildjet.com runners and have no regrets.
How can a top scientist be so confidently wrong? R. A. Fisher and smoking (2022)
I have docked my Steam Deck to a TV. I have also used physical media with a Steam Deck. The USB port lets you do both of these things. I also just plug it into my laptop dock to play more desktop-oriented games.

The Deck works for me since I rarely play for more than a couple of hours in a stretch (so I don't need 5 hours of battery life), and I don't need to stick it in a pocket. It's "just a PC", so you can still play non-Steam games on it if you need to avoid the Steam ecosystem for some reason. Its direct competitors (Asus/ROG Ally and the Lenovo Legion and others) show there's a market for this type of device.

The Switch satisfies the needs for a lot of people people; great! Good ideas will cross-feed with those in the handheld PC gaming device realm.
My favorite is Lost Highway. And here's what I think it is "about": unbearable remorse.
I feel like I can build web apps drastically faster in Python than with C#. I find myself writing a lot less boilerplate and things, even when using a full stack framework like Django.
David Lynch, Maker of Florid and Unnerving Films, Dies at 78
Weebo: Real-time speech-to-speech chatbot running locally on M2 MacBook
We absolutely do design roads for all kinds of people to make you crash if you do not follow them. In fact, on pretty much all roads, you will crash if you decide not to follow the road, and frequently you will crash into a tree or a building. Drivers generally see this kind of design and complain about it but slow the hell down. Cyclists seem to be the same.

There is a sign ahead of this ramp saying in very big letters "BIKE LANE ENDS." It's up to the bikers to decide how they want to use that information. The sign, the ramp, and the end of the bollards marking the bike lane are visible at quite a long distance.

As for the street sign, it's a street sign. It's where the street is. It also tells you exactly where to use Google street view to get full context.
People buy 100k cars online nowadays, why wouldn’t a great online presence also work?
> but I prefer a choice every day of the week

That would be an interesting discussion, but that's not on offer. What is instead on offer is dozens of choices every day of the week. Is any person really expected to read and understand a dozen or more privacy policies every day?
I'm going to blow your mind, but at one point you weren't subscribed to the channel. You found that channel likely through the algo.
One of the most brilliant failures of move history
That's interesting because in Polish it is "ek" and my great-grand mother was part of the diaspora there before the war.
I thought I was the only one who preferred David Lynch's Dune. I'm glad to find out I'm not alone. I explain to people that it depends on if you're a bigger David Lynch fan or a Frank Herbert fan. I have nothing against Herbert, but I guess there's something about Lynch's work that speaks to me, even a movie like Dune that he himself hated.
The third season of Twin Peaks is the best piece of television I ever watched. Rest in peace, you will be missed.
Provisional Guidance for Users of LLM-Based Code Generators
Today no cinema.
It leaves behind tracked files that were moved or deleted between revisions.
"Fear and anguish of parenthood" as a movie?
Chainmail-like material could be the future of armor
Don’t collect PII -> don’t show cookie banners. It really is that simple. You don’t need your visitor’s PII. You don’t deserve it “just because”. The visitor does deserve to choose if they want to consent to it.
> 3. If a problem can be framed in a way that a coding agent can solve...

This reminds me of the South Park underwear gnomes. You picked a tool and set an expectation, then just kind of hand wave over the hard part in the middle, as though framing problems "in a way coding agents can solve" is itself a well-understood or bounded problem.

Does it sometimes take 50x effort to understand a problem and the agent well enough to get that done? Are there classes of problems where it can't be done? Are either of those concerns something you can recognize before they impact you? At commercial quality, is it an accessible skill for inexperienced people or do you need a mastery of coding, the problem domain, or the coding agent to be able to rely on it? Can teams recruit people who can reliable achieve any of this? How expensive is that talent? etc
> Have you ever tried to dock a Steam deck to a TV?

Yep, works great with non-proprietary docks vs even using a 3rd party dock on Switch has led to bricked units.

> Have you ever tried to use physical media with a Steam deck?

I haven't tried, but I'd be surprised if plugging in a USB optical drive wouldn't work. That'd be pretty silly though, but so are some of the Switch physical releases when the bulk of some games isn't actually on the cartridge.

I think the better thing to look at is DRM instead of specific transmission format. Steam itself is a grey area for DRM (some games are DRM-free IIRC), but you can also use things like Lutris... or generally whatever you'd like. Takes a bit of tinkering, sure, but a whole lot less tinkering than getting anything unofficial to run on a Switch.

> Have you ever tried to get 5 hours of battery life with a Steam deck?

Yep, works great. I'll still give the point to Nintendo because they prioritize battery life so much more, but if you aren't running the SD at full tilt with a large 3D game, it can get decent battery life.

> Have you ever put a Steam deck in your pocket? (I do have big pockets, but at least with the Switch Lite, it's possible.)

I would love a Steam Deck Lite or something. That's probably the biggest reason I keep my Switch Lite: it's easy to just toss in a bag on a whim while the SD (and other Switches) require planning to actually use them.

> Nintendo will be just fine.

Yup. They're probably still sitting on piles of cash from the DS and now Switch. People were saying Nintendo was doomed when the Wii U did poorly, but others at the time rightly pointed out that they've probably got enough runway to have a few more total flops of consoles.

> I personally will never use a platform that can kick me out on a whim, or could screw me the moment Gabe Newell gets hit by a bus.

Losing Newell is a valid concern (again, for Steam as a platform), but Nintendo is certainly an interesting choice to say they won't kick you out on a whim, given their track record of bans, lawsuits, and just being particularly litigious.
You talk about piracy, I talk about just having to bring a single device of the devices I own with me and using a paid product on another paid device.
Probably didn't help, but the man had been smoking since he was 8 years old and was at the point where he needed supplemental oxygen just to walk.
The beefier specs would be wasted though since game developers would still be primarily targeting the handheld (since that is still their main offering, so that's what most people have).
> ... post that stuff online.

> I do not understand why that's difficult

It's not. Having worked on the other side, both in startups I founded and later as a senior exec inside the large F100 valley tech company we were acquired by, this inability to communicate what 'customers who want to buy' 'want to know' constantly mystified me.

After deep diving into why it wasn't working at BigCo, I think the root cause is systemic and it's the bottom ~80% of sales and marketing people. In my experience, the top ~20% of sales and marketing people are generally excellent. But the rest seem to be 'performing' their job functions generically without deeply thinking through how to most effectively communicate and sell "this product" to "this customer" in "this context". That's why so many product information pages follow templates which supposedly implement 'best practices' but in reality are pretty terrible. And it's probably why so many product pages lead with vague puffery. I had an anti-puffery rule for marketing copy: only lead with statements of fact about what makes this product different from the top three alternatives which can be proven true or false. "Best in Class"? Nope, anyone can claim that. Say something concrete that matters that we could get sued for lying about.

Typical entry level salespeople don't really care that most introductory sales calls are a waste of everyone's time. They are paid to do it anyway - and it's one of the few pre-sales metrics that can be easily tracked, so lazy sales managers make increasing introductory sales calls an objective. That's why anyone suggesting #nocalls, or even just offering it as an alternate sales funnel, faces so much resistance in an existing sales structure. Even proposing an objective A/B test of #nocalls met was met with departmental 'circle the wagons'. After talking it over one-on-one with different stakeholders, there was no clear reason they could articulate to oppose trying it. I suspect it was part "this is the way we (and everyone like us) always does it" and part fear that if it worked it would upset current metrics, budgets and even head count. Professional mid-level managers in large companies aren't interested in upsetting their departmental apple cart (or turbo-charging it), they just want to add a few more apples to it each year.
Soup You Can Suck On: Introducing Progresso Soup Drops
A friend described calls as "high bandwidth information transfer."

An average typing speed is 40wpm but an average conversation is between 120 - 150 wpm so about 3 - 4x bandwidth.

Calls also offer sub second latency and maximum priority.

When you add video and audio in there, the pure amount of data transferred is higher.
Ah. I'm American so I assumed that would be per person
https://news.ycombinator.com/item?id=42730000

https://www.nytimes.com/2025/01/16/movies/david-lynch-dead.h...

https://archive.today/NAhZi
Some things are sure. But not most. You wouldn't expect to go to McDonald's and they tell you (or even know) how much the fertilizer to grow the corn that feed the pigs that made the bacon contributed to the price you pay for a burger
just want to point out that ultrawides are bad for movies and games(at least currently), even though they're great for coding and other research related tasks from experience
You said what I wanted to say.

I think there is a niche market for tools that allow individuals to train their own recommendation systems.
It is always fascinating when Americans re-discover that old things actually exist.

But, as they say, an American thinks that 100 years is a long time while a European thinks that 100 miles is a long way.
> IP address certs sound like a security nightmare that could be subverted by BGP hijacking.

The attack scenario is exactly the same as hostname certificates, which are often validated by HTTP or TLS ACME challenges.

> Does accessing the ACME challenge from multiple endpoints adequately prevent this type of attack?

Yes. You'd essentially have to MitM all traffic towards the IP for it to work, and with more and more networks rolling out BGP origin validation a global BGP hijack becomes harder and harder to pull off.

You'd still be in trouble if you expect your own ISP to be hostile, of course. Don't single-home with an ISP you don't trust, or stick with domain name certs and force DNS challenges.
Absolutely. He's my favourite artist, and for me no one else comes close. R.I.P Mr. Lynch.
someday 99% of all computing power is going to be used to generate and summarize vast amounts of text.
I think you're confusing me with other folks on HN. I value cohesive high trust societies so I'm personally in favor of assimilation and much more gradual changes to any culture.

I think a change from 96% to 67% in 76 years is a catastrophe for culture indigenous to a region, and it's not a surprise that the Nakba followed such a rapid change without assimilation. The rate should be one where outsiders coming into a society become part of that society instead of splintering the society.

In chemistry terms, it's the difference between a solution, emulsions, suspensions and mixtures. In my mind, the goal should be cultural "solutions". If the rate of change is such that you end up with enclaves that resist mixing, then that leads to decline of trust and civic engagement. You end up with a society that is highly political and fragmented and liable to balkanize and potentially engage in armed civil conflict.
Yes, all the big search engines respect that meta tag. Some of the big abusive AI crawlers do too, kind of defeating the (stated) point of the tarpit.
At the time, at least, I don't recall seeing SNES as a "revolution". It had better graphics etc, but the form factor was the same, and games were broadly similar, so it was more of a luxury option.