skysight-inc/HackerNews huggingface dataset:
Sequence the cancer. Get involved in clinical trials early.

There's no "biohacking" cancer without pharmatech. It mutates. You would need a two or three sided attack. There was a concept on causing the cancer to have an "extinction event" and I agree with that, due to how cancer mutates.

We're also missing tools to see how effective treatments are, on a day-to-day basis. This may be out of technological reach.

Also, keep in mind, the blood-brain barrier is difficult to deal with.
What else are they gonna do, they’re probably happy they’re relevant for once.
I guess you could argue that climate risk isn't sufficiently priced in for some particular places, such as LA or Miami, but the article didn't seem to get that detailed.
>Can it get the wifi SSID? Is that a permissioned property on Android/iOS?

It requires location permissions since forever ago, specifically because of the risk you described.
Greed is a lazy excuse. Why not just say badness or villiany?
A while back, I was looking for a project amateurs could do for experimenting with Transformer alternatives and optimization algorithms. My concept was grabbing objective, test functions from the literature, making custom ones based on realistic data, and layering them together based on real-world depth. Then, training various approaches on them using consumer GPU’s or spot instances of high-end GPU’s.

What I read in this paper blew that idea out the water! I mean, it’s still doable but you’ve far exceeded it.

I love that you covered many types of structures, used 8x consumer GPU’s more like OSS folks do (widely-accessible pretraining), claim no copyright infringement for pretraining, and use enough techniques in ML that people can enjoy Googling stuff for days.

I do have some questions about what I might have overlooked in the paper.

1. Is the training data and code available to reproduce the model? And iteratively improve its architectural decisions?

2. Most authors claiming their data was legal or open were actually committing copyright infringement. Your method might dodge that if users generate their own synthetic data using methods they can verify aren’t themselves encumbered. Is that code available under open licensing? If not, would you offer it for a fee for companies or free for researchers?

3. What specific, common uses could amateurs try that would display the model’s ability in a business setting? (Both to drive more research or build products on the model.)

I thank you for your time.
I'm always amazed at the level of entitlement in some people. He spent his free time creating an OS from scratch with a great community behind it and shared his knowledge about how to build an OS from scratch across 100s hours of YouTube.

One of SerenityOS Apps (Ladybird) grew larger than SerenityOS itself which he's devoted the last couple of years to, trying the impossible feat of creating a modern web browser with a skeleton crew but yet still manages to attract idiotic, self-righteous low effort commentary like this. Andreas has already given the world plenty, owes nothing to me or you or anyone else, especially with what he devotes his future time to.
> Addiction and other disorders are common among people with terminal or not-so-great prognosis

It's horrifying that we don't just give them what they want. Who are we to judge?
Go ahead and do it. Let's see how their precious AI datacenters compete against the Molotov cocktails of the unemployed.

Unless there's a plan to prevent poverty as a result of mass unemployment, there will be another Luddite movement.

For what it's worth, the original Luddite movement was 100% right. They were slandered as being irrationally afraid of technology, when the reality is that they valued human outcomes over corporate profits, and didn't take well to being replaced by machines.

Let's just hope the next Luddite movement isn't defeated the same way the original Luddite movement was defeated (by murdering the Luddites). There's a growing attitude in America right now to rid society of exploitive ruling class elites. I foresee a "let them eat cake" moment coming soon.
> > advance

> you can just manually make any letterform 2x width,

Yes. Any glyph may be wider than its advance. The advance, however, must remain the same across all glyphs. If it does not, the font is not monospaced.

The passage you’ve quoted refers not to the width, but to the advance.
I pay $89 for 15 months of Outlook for Families thing, which gives me onedrive, office and ad free outlook, credit monitoring and centrally managed anti-virus for a family of 6... You are not beating that in any other provider. Credit and dark web monitoring alone per person will cost that much per month.
Nominal wages are basically never lowered, but real wages can be easily lowered by giving out annual raises that are below inflation. Since 2020 the CPI is up more than 18%. [1] So if you're not earning more than 18% than you were then, you're receiving a lower real wage.

This is one of the many reasons inflation is such a horrible system. It makes it really easy to invisibly abuse labor. People are trained not to spit on "gifts", but if you received a 2% raise each of the past 4 years, your real wages would now be down by nearly 10%.

[1] - https://fred.stlouisfed.org/series/CPIAUCSL
Every single person I know who died from cancer young went down this route, from trying weird cures to going and seeing John of God in Brazil. Zero cured or delayed the cancer. All delayed acceptance and GREATLY regretted wasting that time and wishing they had had more time in the acceptance phase not the 'this can't be real' 'I can't die' 'There has to be something' denial.

This can and does hurt them, and is cruel. If they want to inflict in upon themselves, that is one thing. But to do it because OP has had enough losing friends is selfish. You will never stop losing friends to death, in fact, it will only accelerate from here on out. It will never get easy. In fact, it compounds as more and more joy/light/goodness leaves the world and those you turned to for support are gone. It's part of the deal they made when our parents volunteered us for this existence.
There is no group of people more fitting to be replaced by machines. Unfortunately, they have the means to ensure that they will be the last to be replaced.

Brace yourselves for technofeudalism...
I printed the PDF on A4 paper, but Tetris doesn't work! lol
Thank you! Good find!
Also in Asia, I know of a few smaller ones, but they come and go - and with space at a premium I’ve not found them that useful.

I think it’s more about the community than the physical space though (to a point)
The first sentence of the article explains:

> Surface electromyography (sEMG)

EMG[0] require a needle in the muscle, sEMG is an improvement.

[0]: https://www.mayoclinic.org/tests-procedures/emg/about/pac-20...
Make sure to read Jake Seliger's blog. He really details the process on clinical trials. Rest in peace.

https://jakeseliger.com/
Just ask yourself would you buy $4 mln house on a 30 year mortgage, that you cannot insure against fire hazard, and then have a risk of loaing it in a fire every year ????
It is odd. The product of a mind which clearly thinks very highly of itself.
I am not sure whether relatively rare events (your specific area burning is still a relatively rare event) get priced in by individuals.

Lots only discover insurance problems after they have signed on a home.
Is there any data, not anecdotes, that H1B drags wages or working conditions down?

US Tech has the highest salaries world.
The fastest object was manhole cover that was blasted into space by nuclear test
I don't use banking apps, but you usually can get around this with Magisk's DenyList.
Fuck ivermectin and fuck you for even suggesting it. It doesn't work on cancer, end of discussion. It works by paralyzing worms on ion channel that humans DON'T have.
> I believe some devs were probably replaced by AI, but not a large amount.

I'm not even sold on the idea that there were any. The media likes to blame AI for the developer layoffs because it makes a much more exciting story than interest rates and arcane tax code changes.

But the fact is that we don't need more than the Section 174 changes and the end of ZIRP to explain what's happened in tech. Federal economic policy was set up to direct massive amounts of investment into software development. Now it's not. That's a real, quantifiable impact that can readily explain what we've seen in a way that the current productivity gains from these tools simply can't.

Now, I'll definitely accept that many companies are attributing their layoffs to AI, but that's for much the same reason that the media laps the story up: it's a far better line to feed investors than that the financial environment has changed for the worse.
Chipquik works fine. There’s probably better stuff but it is consistently good and doesn’t seem to go bad (i can’t tell much performance stuff between a roll that’s old enough to have the label rubbed off and a brand new one).
The question is probably more like why aren't we being invited to their parties. Word of mouth was cool back in '85. How much cooler is it post-internet?

I wonder where they're finding the space now that all the old warehouses are worth a mint.
Military? Glioblastoma is correlated to military service in the First Gulf War
Exercise can supposedly help outcomes for some types of cancer—-I wonder whether the mechanism is similar to that of fasting. The supposed mechanism AIUI is that exercise makes less glucose available to the tumor. Podcast with more info here: https://overcast.fm/+6j6rLbfGM
All cancer treatments are probabilistic. There are no cures, just interventions that increase survival rates. There are no honest sentences that begin with "every cancer".
It's just not that good beyond basic tasks.
Ironically, LLM’s seem most suited towards replacing many of the functions middle managers perform. But those folks would never allow their own role to be outsourced or automated away.
It reached the title cap on the free HN plan unfortunately
Might be worth pointing out that "own data" actually meant "quite a large amount of OpenStreetMap".
It's long, so I'm skimming a little and... flying cars. If you don't know why we don't have flying cars, you're not a good engineer.

It really doesn't matter what prestigious lab you ran, as that apparently didn't impart the ability to think critically about engineering problems.

[Hint: Flying takes 10x the energy of driving, and the cost/weight/volume of 1 MJ hasn't changed in close to a hundred years. Flying cars require a 10x energy breakthrough.]
To be fair, US working conditions are pretty bad compared to EU. Sure, Chinese conditions might be worse, but US conditions aren’t good to begin with.
If only it had a name that was more indicative of that, like UNKNOWN, or UNDEFINED or INDERTIMINATE or something.
Everyone in the world knows that with current AI, you need probably a quarter of content writers to deliver the same output.

To pretend that there is a possibility that there would be no effects on hiring is foolish. Not saying it would increase unemployment, just shift the work.
My dad's old Telus set-top box way worked better than his new Telus box for one reason. It stayed on the same channel even when you turned it off. It didn't show a screen of apps if you left it alone for too long or turned it off and on.
House prices aren't inflated.

House prices are high because there's not enough supply in and around the jobs. There's not enough supply because of zoning regulations. Zoning regulations were put in place to keep house prices as high as possible.

As long as there's not enough supply to meet demand house prices will trend up towards the maximum the market can afford. When the opposite happens house prices tend towards the cost of construction.

Until just a few months ago over 90% of all the residential land in California was zoned single-family exclusive.
My uneducated guess is snap
If you can't insure it against fire, no bank is going to give you a mortgage to begin with.

Banks aren't in the habit of letting their collateral burn to a crisp.
What temperature do you have it set to?
Is it really more complicated to make a video game that a kernel?
I don't consider myself knowledgeable enough to make a full kernel by myself but I did manage to make a full 3d video game by myself.

Also I'm not speaking about making a game engine along with the game.

Having a kernel dev job is different than making your own kernel, speaking on a "world builder" perspective.
Presumably you read the section where Brooks highlights all the forecasts executives were making in 2017? His NET predictions act as a sort of counter-prediction to those types of blind optimistic, overly confident assertions.

In that context, I’d say his predictions are neither obvious nor lacking boldness when we have influential people running around claiming that AGI is here today, AI agents will enter the workforce this year, and we should be prepared for AI-enabled layoffs.
Can you even get a mortgage without insurance?
There are two (I mean three) reasons that home prices are inflated.

1. There are a lot of people trying to buy homes vs the supply of available homes on the market.

2. Rich people are looking for investments in real estate and buying up property to lease or rent it back out at even a higher market rate.

Edited to add:

3. Zoning restricted to keep new construction of high density housing from being built.
> there's not enough supply in and around the jobs

Why the anger at immigrants lately? Hint: 11.2 million illegal immigrants need to live somewhere. (Personally, I think the smaller regional banks have more responsibility to answer for this.)

If Trump is successful in his deportation efforts, house prices will likely fall through the floor, and (huge surprise) the poorer and younger ends of society will be extremely grateful, possibly even electing his successor figure. This could have been easily avoided if adequate housing had been constructed.
> since now total costs have to go up for their profit to go up.

And yet, they deny claims, despite that denying a claim reduces their profits.

> to carry water for private insurers.

Because insurance it utterly irrelevant to the issue. The problems in the US lie at the Dr/Hospital level, not the insurance. Procedures simply cost too much, having the government pay for them will just makes things worse because government always overpays for things.

You want to solve things? Make medical tuition free, and remove ALL caps on number of doctors (especially difficult with residency, but it can be done). Then reduce rates for services.

Someone should start a fully integrated company: They educate you, find you a residency, and hire you. In exchange for free tuition you agree to work for lower rates. (There will need to be some details to work out obviously, since you can't force people to work.)
That is a reason inflation sucks, but there are many reasons for why alternatives suck even more. Deflation strangles the economy, while basing your monetary supply off the amount of metal you dig out of the ground results in a tag-team of uncontrollable deflation and inflation taking turns.

Unless you're planning on doing away with money entirely, it's the best of all possible worlds.
I recently supervised a Hackclub Counterspell event at our office. I was there only in the capacity of being an adult in the room, for health and safety and safeguarding reasons.

The entire event had been organised by a single teenager, with mini workshops, hack time and a global show and tell.

Kids that attended were not only coders, but musicians and artists as well.

The whole event was amazing, with more pizza than I thought it possible to eat.

The kids produced some genuinely interesting games, learned some new skills, and had a great time socially.

I fully intend to support more events in the future.
Why would/should they? I've never paid for curl. Who even develops it? Sounds like a thankless job to fix obscure worstfit bugs.
No one said scam (although in the case of Tesla it absolutely is). It's just not a solved problem yet.
It's a stretch to call out a game for tracking every IP use use and trying to location track you using that? A game should not be trying to track my location at all, not get a pass because technically it's not very accurate.
Human vision works this way. To fix the latency problem (actual event hff happening vs signal transmitted to your brain) human vision is constantly predicting what you should see, your brain tells you that is what you saw (the prediction), and then the brain does reconciliation after the fact. Your brain will scramble for coherency when prediction and reality do not match. This trickery is why it seems like you see events in real time, when there is actually a significant delay between event and perception.

Though, there are error correction mechanisms, systems for validation, and a coherent underlying model of the world that is used by tthee brain.

FWIW, it is likely the most used set of neuron connections, sets of millions in play and their interconnections being the important part. That subset being one of billions of others with thousands of connections between each neuron - keep in mind it is not the set of neurons firing that matters, but the set of connections firing. The set of connections is a vastly large number.

Like, if you have three neurons, your brain can encode 10 data points. Let's call these A, B,C. A firing and terminating is one (so three for each), each edge, eg A to B is another three, each set of two edges, eg A to B to C (three more), and all three edges for one more. Then keep in mind you have billions of neurons and they are each interconnected by the thousands.
This may be of interest: https://amp.abc.net.au/article/103610270
The tools will get better in time, with human assistance.

They will learn how to get better at providing results.

Nowadays, there's confusion, however, there is room for improvements.
That's only really the case for cash buyers though, right? If you have a mortgage, the bank will demand you have sufficient insurance.

There's a case to be made that places like SoCal and Florida having State/Federal discounted fire or flood insurance is an obvious problem. I can understand the "we don't have a way to kick everyone out of this dangerous and potentially historic area" zone, but it ends up being a subsidy of taxes from people living in more sensible areas to pay for the predictable damages to more risky areas.

If you're rich enough to buy anything in LA in cash, you're likely rich enough to eat the loss if your house burns. If you needed a mortgage then you're constrained by the insurance companies that increasingly are pulling out of areas like this for exactly this reason.
Yeah that's what I was thinking too while reading the article. For a tech-focused person, sure, input switching might me obvious. But to a lot of people having only active and valid inputs being selectable might be the best solution.
Same symptoms. Latest Firefox and (Ungoogled) Chromium on Linux, latest Firefox and Edge on Windows.
Econ 101. If an employer can pay someone less to do the same job, they will.

https://www.epi.org/press/a-majority-of-migrant-workers-empl...
I think the argument is that house prices are high because the government backs housing loans, so they don't represent a free market. Easy access to government creates more demand than supply.
The end result of relying on self-driving cars too much?

https://www.youtube.com/watch?v=040ejWnFkj0
Sounds like I'm hunting through menus on the weekend....
Those employers are going to have to find solutions for keeping themselves around. There’s always a tipping point where enough population is unemployed/impoverished that society starts to collapse. Of enough people are unemployed, who is going to buy all the stuff? Who is going to pay the taxes? Who is going to make sure the employed people can ensure their own safety?
> Nine of the Golden State’s 10 largest infernos since 1932 have occurred during the past decade, according to the local forestry and fire protection department.

With how far technology has come since 1932, I personally believe incompetence is being exposed not inflated home prices
41% of incendiary articles are purely written to gather clicks.

Think of the hilarity and irony of the title itself.

How could you, really, interview All of the employers Worldwide, and ask them an even relatively correct estimate of a 2030 figure, when they can't even predict what Q3 will look like accurately. "Oh but it's just trend gathering".

41% of the business today won't exist by 2028.

And reduce, reduce staff by what? 2%, 10%, 50%?

This is just so silly.
The Nanny Scale
I also shop around for lower prices. I think many people do, at both work and at home.
>> It's just not that good beyond basic tasks.

A ton of dev work is basic tasks, esp writing unit tests.
Have they used GC.AI? Heard some buzz about it but kinda skeptical myself of these tools
> Why the anger at immigrants lately? Hint: 11.2 million illegal immigrants need to live somewhere.

Are they really buying this extremely expensive real estate with their low wages? Seems impossible. More likely, they will lower the already very cheap housing in the middle of nowhere.

> If Trump is successful in his deportation efforts, house prices will likely fall through the floor, and (huge surprise) the poorer end of society will be extremely grateful, possibly even electing his successor figure.

Far more Americans live in owned-homes than not. That's exactly why this problem has been so intractable in the first place. Those folks will not be happy.
Sigh, why can't we have nice things?
Tactility
It's covering significant areas of 3 major metros, and the core of one minor, with testing deployments in several other major metros. Considering the top 10 metros are >70% of the US ridehail market, that seems like a long way beyond "non-existent" coverage nationally.
Small suggestion - you can edit U.S. to US and gain 2 characters.
It’s a wash IMO. Both the actual situation and the article are unclear. The article probably should have been shorter with limited information but there’s pressure to make an article not be very short. The gist of it is that TikTok is at least somewhat hassling their already stressed employees which seems it needed to be said, but it’s unclear whether they’ll be charged these hours once things settle down.
Are there any examples of new jobs that are being created because of AI?

Or perhaps a boom in small businesses as AI makes it more feasible for entrepreneurs to get leaner?
Here’s a summary of all of the current treatments and near future treatments for GBM/glioma: https://docs.google.com/file/d/1kTa3eamaL91Smjh9r_0CYv5OYFX4....

This is as complete a list as you’ll find, written in plain English, with citations for every part of it. Slightly out of date but there hasn’t been much that’s new and different since last year. Vorasidenib was approved recently in USA and it’s the most effective IDH inhibitor - worth reading more about.

The document is focussed on glioma but there’s a lot of GBM research. Unfortunately the short answer is that there is no cure and there is treatment that might be a cure under development. There are treatments that slow the course, and the patient’s doctors know all of them and they will recommend what’s best. This is an area of medicine that is hard for amateurs to learn about, and a neurooncologist has decades more training than their patients. The reality is this is a horrible disease that currently has no cure - and the treatments that work are all complex medicines prescribed by specialists.
To be unfair, you mean.
Does it drive anyone else crazy when an author posts 15,000 words (yes, there are that many in this article) when 1,500 would have more than communicated the relevant information? The length of this article is almost comical.