skysight-inc/HackerNews huggingface dataset:
I'm wondering what language this code was written in and if there couldn't be some significant speed gains by threading it differently. Is this modeled down to the molecular level, or is it a simulation of higher processes with known results?

For one thing, if the protein interactions are abstracted and what's chewing things up is the modeling of them, then it would make more sense to use a lot of powerful GPUs; then you could spread the calculations out over a bunch of Xboxes.

Secondly, despite the huge amount of data generated, you should be able to monte-carlo outputs for inputs on a thing like this. In essence, use it to generate a rainbow table of states, inputs and outputs so you can then run a multi-cell organism much more quickly. Assuming every cell has the same DNA.
Equals? Hardly. Some people, for example, are worse than others at English grammar--thus the OP.

What does respect mean to you, out of curiosity?
Guts. This guy has guts. Hoarding away a 3m bonus like that has an implicit statement of "I'm afraid for my own fiscal future to the tune of 3m dollars" stamped on it. Instead, he gives it away, telling the world and his employees that he is confident, nay, OPTIMISTIC about the company's future.

To contrast, take the typical American CEO: he or she would have taken this money, offshored it, spent another couple of years going to board meetings, and then jumped ship to another gig in some other company's c-suite. You know what I call that person? A COWARD.
Well, they did study the bacterium M. genitalium.
Cripes, they've still got that shitty name.

Anyone from the United Kingdom will immediately associate the name with the English Defence League, a violent far-right Islamophobic street protest movement.

As branding ideas go, having a name that has that connotation is a really dumb choice.
Yes, it's becoming legal sometime later this year or very early next year. SEC is currently working on the regulations that we'll all have to follow in making use of it.
If Neil Armstrong Had Instagram
One thing I am surprised by with these types of theories is the lack of awareness that some people have happy childhoods with parents who don't scar them in any way. It's like it's taken as a given that a legacy of sadness runs through every family.
> Many disagree with me on this point of view, but routinely I've found that those that express themselves well in their native language write better code.

Many people with perfect grammar communicate terribly, and many people with much less than perfect grammar communicate very effectively. If effective communication is important for a job position, perhaps looking directly for that skill would be more productive and fair?
Researchers find link between brain structure and altruism
No. That's the free market exactly. It was his money. He did with it what he wanted, even and especially if you didn't think that was what he should have done.
Clojure's killer app is managing complexity. This allows you to keep your mental stack clean.

With OO, you have to keep track of the state of each object and how each method affects that state. With Clojure, you don't need to be concerned with the guts of a function, just the inputs and outputs. This keeps your mental stack from building up and makes programs easier to understand and debug.
I can't seem to edit my post, but thanks to everyone who replied, upvotes all around.
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I really wish there was a transcript or video. The better the presentation, the less useful the slide deck is on its own.
Hey, ease up. It must be terrible to be enslaved to a worldview that has accumulation of wealth as its ultimate goal.
>There are households where the nanny raises the children and parents see them perhaps less than one hour per day. Are you going to tell those parents that by your decree they should not have had the child?

I'm not going to say that they shouldn't have had the child because there is no point, they can't change the past. However, I would tell people who are planning to do this that they shouldn't have children.

There are plenty of children who are raised in poor environments who go on to lead normal lives. There are some children who are raised in front of the television with almost no parental involvement who end up perfectly normal.

Just because some children overcome a bad environment doesn't mean it should be socially acceptable to purposely introduce a child to a bad environment that you could have easily corrected.

There is loads of evidence that failure to properly bond with a primary caregiver causes significant problems later in life.

What is the likelihood that a paid servant will love, and develop a bond with your child. What is the likelihood you will be able to keep the same nanny long enough for her/him to bond with your child? Because if that doesn't happen, and you see your child less than 1 hour a day, you are demonstrably harming your child and the society that eventually has to deal with him or her.

If you have no interest in raising and nurturing your child, the only possible reason for procreating is selfishness. Children aren't pets.

>That's your opinion and I'm guessing it's based on cultural expectations, nothing more. Your culture is not everyone's culture.

There have been cultures where throwing baby girls in garbage dumps was acceptable, is that an argument for the moral validity of infant exposure?
Get Uncomfortable To Get What You Want
One of my old bosses thought that all Lenovos possessed BIOS-level malware that could be activated at a moment's notice by the Chinese government should the US ever got to war with them.

He was a weird dude.
As I said: regardless of your view of her work, and I've got similar issues to yours, she was tremendously religious. And yet, profoundly troubled by doubts about her faith. Which is to say, confidence in her faith had little to do with her ability to become a religious exemplar, directly contradicting a major tenet of the article. Anectdata and all that.

Not so far as I've read, troubled by her actions. If you've got any documentation that she was, that might be relevant.
Excerpts: THE MONEY SPIDERS, Birth of a Nation . . .
You're right, I don't. But at this point, it seems like gluttony. Eating for the sake of eating. Sure they'll gain some value out of the team and their insights into email, but is their contribution going to be more so within Google than outside of it?
Well, Wikipedia's shutdown played a pretty significant part in the SOPA/PIPA action... and Wikimedia has decided to not take part in the Internet Defense League.

https://meta.wikimedia.org/wiki/Requests_for_comment/Interne...
A similar thing happens to a Motorola Xoom that own. Turning the screen on and off always fixes the issue. It's usually rare, once every month or so, so it's not that annoying, but when it happens, I end up swiping multiple times and then realize, oh I've run into that problem. I can live with it, but would be nice if it was fixed.
Cynical wondering: Is this real, or a clever way to package company-wide bonuses for PR? Seems like if your company just had a great year and you wanted to boost morale with 300$ bonuses, this is a way to do it and maximize press and positive attention in the process.
Please lose the Facebook/Twitter popup. Get rid of a lot of that ad space and social media buttons. "News" should not be a major focus. Programming, gaming, science, and the arts would be a good start.

Stop quoting Silicon Valley insiders and relegate them to a corner of the site if you must place any emphasis on "tech". They did a lot to ruin Digg with the endless self-promotion. Acknowledge Reddit like they never did and take inspiration from subreddits, but make them easier to discover. Reddit has yet to do this and it is a noticeable deficiency on their part.
I would take 10,000 Nokia staff over Elop any day of the week.
This reminds me of del.icio.us and the new team, that rewrote it from scratch. It is very similar - old product that shone in the past but was out of focus in recent years.

The rewrite didn't work right; old users were angry and new users didn't appear.

But maybe this will be better, who knows.
On the other hand, with the serial comma you get "I would like to thank my mother, Ayn Rand, and God."
I think this news is huge: I suspect they probably took a lot of shortcuts and aren't simulating everything at the level of individual atoms. However, this type of system could be refined and perhaps give a 99% accurate simulation of a cell.

Imagine if you could get the DNA from a cancer cell in a human patient, as well as the DNA of a normal cell, and then test the effect of a million different randomly-generated molecules until you find one that kills the cancer cell, but not the normal cell.

If you could scale the performance of this type of system and allow it to simulate Eukaryotic cells (much more difficult) it might let you cure most cancers!
12,000 views on The State of Venture Capital
Now there's a backhanded compliment!

Dude, it doesn't matter how rich he is. He gave away his own money to the people who are making him rich as a gesture of thanks and goodwill. WTF would you find anything to belittle that?
Not necessarily. I don't know the tax code in Taiwan at all. In the US, he might have received the $3 million, paid income tax on it, and then gifted it to each employee, who would not have to pay tax on it. Or he could have asked the Board of Directors to not pay him the money at all, in which case he would not pay taxes on it, but each recipient would have to count it as income for tax purposes.
> All of their customers (myself included) invested in the product because it was good, because it worked extremely well, and because it solved problems. I didn't invest in their work at Google

Even worse, I invested in Sparrow because I vastly prefer desktop apps like Sparrow to web apps like GMail. That's sad.
http://wholecell.stanford.edu/

Source code and training data available online; written, of course, in MATLAB. Very refreshing, and I'm looking forward to dissecting this first-hand.
Lot of talk here about their lack of recurring revenue models; the interesting thing I think is that they were developing a recurring revenue facet.

If you missed it, the problem on iOS is that they couldn't get push email support working (they tried to use the VOIP exception but Apple caught it while review), so the talk was that they would offer a yearly subscription type thing that would somehow enable push email.

I'm not sure how much that would have been, but I would have almost certainly subscribed.
Plaintiff can definitely appeal a dismissal with prejudice. In fact, Plaintiff would probably have more trouble appealing a dismissal without prejudice, since the implication in a dismissal without prejudice is that Plaintiff can refile.
I'd say it's exactly the other way round: the CEO definitely has to make decisions that impact the company far more than what 10,000 line workers do, for better or for worse. The open question is whether the commonly used pedigree/qualifications that decide who gets to be CEO actually enable people to make substantially better decisions.
All these aquisitions are more insidious, they are being done by the big players to stifle diversity in the market and continue to solidify their leads on online services under the guise of talent acquisition to better their companies - rather its an effort to prevent that talent from building something that would be a detriment to their positions.
Operating directly on Java classes is pretty standard. Of course you have to be very careful when working with classes which allow mutability, (true in all languages, really) but with Joda that's not an issue.

The only thing you miss out on is that Java methods can't be used as higher-order functions.

My Indonesian is pretty rusty; I should probably update it to say that I understand it rather than speak it. =)
Confirmed: Apple's iPhone 5 to feature nano-SIMs, AT&T
Can any one explain what they mean by simulate? Like to what depth? Do they define different types of cells and their functions and then let them work? Or molecules, atoms? particles?? I strongly believe a "proper" simulation is impossible because we don't even know the bottom of the barrel, so best we can do is define a building block and how it behaves and see it grow from there. Although the coolest thing would be to define the quarks and four forces and then let it organically grow into some kind of matter over time. We can also control time in a simulation which will basically confirm our understanding if the outcome of the simulation is similar to real world.
It was recorded, but waiting for them to publish the video.

If you download the file, however, my notes are in there too.
Harris would argue that even that capacity for self-reflection is just part of a very long causal chain. Every thought you have emerges from somewhere, but it's very hard to find the cause of that thought. You might be able to pin down that "I was thinking X because I was reminded by Y," but that just begs the question, why were you reminded by Y? There are an infinite number of thoughts you could have been having at that moment, but for some inscrutable reason Y bubbled to the surface.

All that said, though I think free will is an illusion, in terms of day to day life it's more practical to act as if you have free will. I believe Sam Harris agrees. He is more concerned about the public policy implications, such as incarceration and rehabilitation.
Nope. Seems to be heavily MATLAB-based.
My vague Googling gets that a human being has 50-100 trillion cells. So Moore's law would say a full human simulation might be 80 years away if it keeps up. I wonder if an organ could be simulated taking a smaller selection of cells, determining their characteristic interactions and extrapolating from there.

The further question with any project for full organism simulation would be how many lines of code are going to be produced and what would the process of maintaining that code look like?
The elephant in the room: why exactly didn't she get a promotion to Googles top tier? Considering that she was one of the first 20 employees there has to be some reason for that. I have the impression that there is some piece missing here.
“The model presented by the authors ... should be commended for its audacity alone"

Audacity, yes we do need more of that. pg says that tenacity if the single most important trait of an entrepreneur. Maybe audacity is a multiplier that brings us the big innovations.
I saw it nearly happen with a dot-com I worked at. "Architectural releases" (e.g. "just cleaning up technical debt") provide nothing but risk for customers and an opportunity for competition to catch up.

In my mind, this is what is meant by phrases like "excellent startup teams are good at execution". They can ride the line between getting features done without becoming bogged down in their own code. It's easy to hack something out. It's easy to spend all your time making in an architectural masterpiece. It's really hard to balance that in a way that allows for continued growth.
I know exactly zilch about this field, so it very well could be something that mundane. However, for spreading calculations across a cluster of 128 computers, I sort of hope they're using something more specifically tailored for the task.

Keeping in mind that my knowledge is zilch, here are some exotic languages that appear to be designed for this sort of thing:

http://en.wikipedia.org/wiki/X10_%28programming_language%29

http://en.wikipedia.org/wiki/Chapel_%28programming_language%...

http://en.wikipedia.org/wiki/Fortress_%28programming_languag...
Redirects to Reddit.com... clever. In my opinion, Reddit is kind of fun in small doses, but the groupthink and mob mentality over there is unbearable.
We had the same problem at MacHeist (people got their specific macheist+ prefixes targeted with spam). Turned out it was our email provider iContact who were hacked. We weren't the only ones. They posted a non-committal blog post about "investigating the matter", which then mysteriously disappeared when they upgraded their blogging platform.

The hack made real damage to our reputation (the "software bundle" space has a poor reputation to begin with, and receiving spam confirmed people's expectations), and they wouldn't own up to it. Be careful with which third parties you entrust your users' email addresses with.
[I think] That just makes it sound like you lack confidence.
http://www.stanford.edu/~jkarr/research.html
look for "more information" links to animations, etc.

http://wholecell.stanford.edu/
contains a link to the code (written in matlab)
No, I did not.

And he did so with misogynist language. Which made me twinge. I don't complain, I state my feelings.

It just shows in what a weird time this was happening.
Setting the size a bit bigger (the default is really small I find), you really need a lot of imagination to see a face in it.
This is very exciting progress, but let's remember that there is a rather important caveat with this sort of thing;

"For their computer simulation, the researchers had the advantage of extensive scientific literature on the bacterium. They were able to use data taken from more than 900 scientific papers to validate the accuracy of their software model."

This is not (necessarily) a model of M. genitalium - it's a model of our understanding of M. genitalium, and as such incorporates in everything that current technology in biological sciences allows us to look at. It takes a huge amount of data from many sources and tries to bring it together on a scale not previously done. However, that data may have significant flaws, biases and ultimately considers only what we're good at looking at (technologically/scientifically speaking). It's awesome, and 100% the right direction for the field, but equally it is not a, "synthetic life form being simulated" as much as, "a very very complicated model which uses huge amounts of multidimensional data to try and replicate the behavior seen in that data".
Yes. Verbs! Good things. (No explicit verbs in this paragraph, though.)

In any case, the comment for a class or method (or whatever) should start with a quick, concrete one-sentence description of what it is or does -- preferably starting with a verb, as you said. If you want to elaborate later, great, but everything needs the one-sentence summary. If I could tell inexperienced programmers one thing, this would be a strong contender. (Other possibilities include "Write your programs in discrete pieces that you can test in isolation, as much as possible," and "Make it work before you make it fancy.")
http://dl.dropbox.com/u/85192141/2012-karr.pdf
I'm not allowed to downvote, but I'd like to. There's a huge problem with the conflation of rational principles with ethical principles.

When we say the "law of gravity" it's a way to understand how the world works, not an edict from some moral authority.
Would coreboot reassure the gentleman? Or would that be dismissed as an anarchist conspiracy?

Seriously: are there any laptops/PCs still manufactured within the national borders of the US?
I wouldn't lump HN, Reddit and "Other" together since Reddit is widely read with impressive traffic. It is a significant news site.
But with the right team and culture and a drunk dimwit at the helm, you'll still going to crash.
Lion’s Mail is the first desktop client that got me back from webmail since April 1st, 2004.
The Order indicates that Kaspersky won summary judgment on noninfringement grounds, not invalidity grounds.

e: Not sure about this, but the Order also suggests that some of the Troll's claims survived summary judgment and are proceeding to trial, so it's not clear to me how complete of a victory this is. I'll check the underlying order (this ruling was on a motion for reconsideration) and the PACER docket and see what I can figure out.
We have no idea what the code looks like. Maybe some knowledgeable engineers took a look at it and figured it would be better in the long run to just design and build something new themselves, instead of inheriting someone else's hairy, warty code. (I am just offering ideas here, I don't actually know how hairy the code is or how many warts it has.)
No. You can't take the percentage of developers in the richest, most developed and well-educated countries in the world and apply it to a population where the majority of people live in poverty.

You can't use stats from job boards because job boards have 90% of their posts from recruiters, so the same job can often appear dozens of times (not to mention dead, fake, etc. posting that plague the job industry).

The rest of the numbers are similarly flawed.
All the new firefox dev tools ship installed.
Without the line workers, there is no product. Without a CEO there is no product. They're both but-for causes (in the legal sense), and in that sense equally indispensable.

What you need is a sensitivity analysis, of profitability of the company versus changes in CEO versus line worker performance. I'd imagine you'd find that a 20% efficiency jump in the line workers would have a much bigger change on the bottom line than a 20% better CEO.
Wow,

Having the code in Matlab seems like a disaster as far as ever making this or similar approaches modular and so usable-by-others goes. And I do know by miserable experience that Matlab indeed what biologists generally use but if biology is ever going to interface with larger scale software construction, it seems like it is going to have to change it's standard operations a bit.

Edit: And this isn't saying Matlab is generically "horrible". It is great at what it does but horrible from my perspective, as a programmer whose task usually is putting pieces of software together.
Alternatively, open-source Sparrow. I don't think it's the source code that Google bought them for.
This is a great example of a field which will be massively impacted by Moore's law. In 10 years time you will have the equivalent processing power in just one computer, meaning hobbiests are going to be able to run these kinds of experiments. Then things are going to get really exciting!!
Exactly. He didn't say, "Well, I guess I don't need this. Here, I'll just let my employees deal with it." He made a conscious decision to not increase his wealth for the benefit of others.
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However, the commit message should describe what the commit does, not what you did.

What happens if I apply commit X to my project? Will it "Fix bug 35035" or "Fixed bug 35035"?
> Now, there's a very good chance that some of Sparrow's UI features will be incorporated into the Gmail web UI and into the Gmail apps for Android phones and tablets.

Why acquire a whole company if all you want is to re-use some of their good UX ideas? You get those for free with the app.

Presumably the talent was another draw for Google, but will breaking up/subsuming the team defeat that purpose?
It says it was a bacterium. So in that case, single cell = organism.
Also the Amazon Kindle is really stupid, doesn't let you do free downloads without a credit card.
Well, that's $10 times a large number of people. Remember the scam from The Office Space where they were stealing fractions of cents? http://en.wikipedia.org/wiki/Salami_slicing

I don't think it's fair to call it fraud, but it isn't because of the numbers, but because it was sold as a computer program, not a service contract.