skysight-inc/HackerNews huggingface dataset:
The developers of these new peptide-based hormone-acting drugs like semaglutide(ozempic) could be called biohackers, but the system they're hacking on - the human endocrine system - is a delicate system. Introducing semi-synthetic mimics of native hormones can go wrong in all kinds of ways, and hormone-analogue drugs have a poor track record (anabolic steroids, DES, etc.) so extra caution makes sense.

Semaglutide is based on a 31-amino acid polypeptide that mimics the human GLP-1 hormone. At position 26, the lysine side chain is conjugated with a fatty diacid chain, to slow degradation and prolongs half-life, and there are some other modifications. However, the target - the GLP receptor - is not just expressed in the intestinal tract but all through the body, in muscle, central nervous system, immune system, kidneys and others. So some unexpected effects beyond the desired ones are likely.

Semaglutide was recently shown to have potent effects on the heart, and possibly beneficial to certain heart disease conditions associated with obesity. Makes me suspect this drug should be restricted to clinically obese cases where strong intervention with close medical supervision is needed. However for healthy people who just want to lose a relatively small amount of weight it really doesn't seem wise.

"Semaglutide ameliorates cardiac remodeling in male mice by optimizing energy substrate utilization..." (June 2024)

https://www.nature.com/articles/s41467-024-48970-2
Not sure if you're being serious, but Reddit gets FAR more traffic than Twitter. Twitter is #43 out of all the sites on the internet in terms of traffic. Reddit is #10. Bluesky is not even on the map yet.
I believe the equivalent ARM64 instructions are in SVE2 which isn’t yet supported on Apple’s M-series chips as of M4, sadly.
Good point. To add to that, I hazard a guess that the legal costs are about collecting everything for discovery, and not necessarily about them causing Google to lose legal cases.
It’s on niantic to prove that it is, not for the millions of unspecting users to prove it isn’t.
chisel is a similar tool in this space https://github.com/jpillora/chisel

I don’t get why headers and requests need to be spoofed if all traffic is over https?
Are we assuming that this search engine is only used by a few nerds, or is the idea to build something that remains good even if it gets popular enough that webmasters have strong financial incentives to game it like they currently do with Google Search? Because the latter sounds like a much, much harder problem, and in particular like it probably requires huge financial resources in order to win the ongoing cat-and-mouse game, if that's even possible.
I doubt they could even if they wanted to. All problems cannot be solved by throwing money at them, and the local governments may not be cooperative or efficient enough to use the money. There are chemically engineered drugs that will gigafry your brain into addiction in one dose getting better every day. Police departments all over the country/west seem to be ineffective at enforcing order, courts are too delayed and too lenient on sentencing, list goes on. Problems on the public side that private enterprise can't really fix without a lot of cooperation. Maybe in a much less regulated world like the Carnegie's, they would be able to try a lot of things without permission, now it would take years of begging to get a permit to build a drug rehab centre somewhere no matter how rich you are and the neighbors would block it.
Check out CSS or FAFSA calculators to figure out your expected family contribution. Financial Aid offices at places like MIT that are need blind fill in the gap between your expected contribution and cost of attending with aid.

The answer to your question is it depends. Some assets like your primary home and retirements can be shielded from expected family contribution. If you've got assets sitting in a taxable account....
They don’t follow it incorrectly either. They just monotonically increase the decimal version for every non-patch release. They do tend to consolidate more disruptive changes to .0 and .5 though.
> One can see how regular folks might consider the practice of automatically destroying chat and email messages after one to three months destruction of material which could be evidence.

I doubt it, expiring chats are widespread even among consumers.
2019-2020 was also a big H1N1 (Spanish/Swine Flu) year, as were 2017-2018 and 2018-2019. Entirely possible that's what you remember reading about or getting. If COVID hadn't happened Spanish Flu would've been a big headline anyways; as it is, a lot of the people who think they got COVID before March 2020 probably actually had H1N1. Before then the case numbers are orders of magnitude higher for flu, but COVID was more transmissible and almost 10x more lethal, and so post-lockdown it dominated.
Won't LLMs make this really easy?

"Hey ChatGPT, find quotes in this 6 TB of chats to support my argument"
> Do you have advice on linear vs srgb space antialiasing?

Unfortunately, this is completely context dependent. One central point is, whether or not the graphics pipeline is instructed to perform corrections (GL_FRAMEBUFFER_SRGB in OpenGL), as that changes the answer. Another point is, in which context blending is performed. Luckily the developer has full freedom here and can even specify separate blending for alpha and color [1], something that GPU accelerated terminal emulator Alacritty makes use of [2], though it doesn't do MSDF rendering.

One thing I can say though: The alpha, the fading of edge, has to be linear at the end or perceived as such. Or rather if the edge were to be stretched to 10 pixels, each pixel has to be a 0.1 alpha step. (If smoothstep is used, the alpha has to follow that curve at the end) Otherwise the Anti-Aliasing will be strongly diminished. This is something you can always verify at the end. Correct blending of colors is of course a headache and context specific.

> fonts have been tweaked to compensate, so sometimes srgb is better

This should not concern MSDF rendering. These tweaks happened at specific resolutions with monitors popular at that time. Especially when considering HiDPI modes of modern window systems, all bets are off, DPI scaling completely overthrows any of that. MSDF is size independent and the "tweaks" are mainly thickness adjustments, which MSDF has control over. So if the font doesn't match as it looks in another rendering type, MSDF can correct for it.

[1] https://developer.mozilla.org/en-US/docs/Web/API/WebGLRender...

[2] https://github.com/search?q=repo%3Aalacritty%2Falacritty+ble...
> It is rather about improving some vision models to predict how the backside of a building looks, right?

This, yes, based on how the backsides of similar buildings have looked in other learned areas.

But the other missing piece of what it is seems to be relativity and scale: I do 3D model generation at our game studio right now and the biggest want/need current models can't do is scale (and, specifically, relative scale) -- we can generate 3d models for entities in our game but we still need a person in the loop to scale them to a correct size relative to other models: trees are bigger than humans, and buildings are bigger still. Current generative 3d models just create a scale-less model for output; it looks like a "geospatial" model incorporates some form of relative scale, and would (could?) incorporate that into generated models (or, more likely, maps of models rather than individual models themselves).
Mee too! Although I like the mentality of "make it easier to use without piracy than with" (i.e excessive drm)
Mastodon doesn't have a non-chronological feed to begin with.

Threads does have a chronological feed but it's very well hidden. In the mobile app, you have to tap the logo to reveal the selector. On desktop you click the arrow button next to "for you".
The Shinkansen runs the fastest Nozomi service about every ten minutes throughout the day at around 5 trains per hour on the most popular routes like Tokyo to Osaka, then during peak hours there's another 5 added in on top of that as well. Plus there are some other slower, cheaper services that run as well and some trains will be express an others stop at more stops or go to further destinations and so on.

I think altogether they probably come to one train every 3 minutes during peak times, but they are not all the same trains and don't all go to the same place and stop at the same stops. There is generally about one train every 10 minutes per platform at a station in my experience, but of course there are usually well over 20 platforms per big station, it's not like there is one platform with a train stopping every three minutes.
there's where you're wrong...
Few academic authors are in it for the money.
It may surprise you to learn pokemon go is nearly a 10 year old game based on 40 year old beloved IP that when it was released did not exist in the same data hellscape we do today, and even if it did, the attraction of the IP would overrule people thinking about this kind of thing. These kinds of comments are extraordinarily disingenuous sounding, particularly when anyone can spend 3 seconds and figure out their primary market is literal children.
Discussion (479 points, 19 hours aog, 615 comments) https://news.ycombinator.com/item?id=42191394

(via https://news.ycombinator.com/item?id=42192598)
I think text to SQL has a fighting chance of answering some question like "How many people bought hot dogs last week?" whereas RAG doesn't.
This isn’t just me talking, this is internal legal advice at multiple large organizations who have been through a great number of lawsuits. It basically boiled down to document everything.
Not the raw data, but if you've used Google maps for directions or looked at traffic, then yeah you have.
Specifically comparing HN to reddit is old as well. It's mentioned in the guidelines to not say HN is turning into reddit. The examples of this shared in the guidelines go back to 2007
>My memory is inside Google we were discussing this risk back in 2003, probably earlier.

Yeah but that was before they hired the incompetent grifter Prabhakar Raghavan and eventually made him head of Search.
Note: I'm also going to reply to your other comment (https://news.ycombinator.com/item?id=42200520) here to save both of us time.

First off, this is a war that America (and indeed the west) isn't a direct party to. The cold hard fact is that this is "someone else's war", and we (America) just got done with the War on Terror which went on for over 20 years. We are war exhausted to begin with.

Secondly, the fact that our response has been lukewarm and insignificant for so long (almost 3 years!) makes the notion of refuting warmongering a laughing stock at this point. We missed the boat in about as glorious a fashion as we possibly could.

Thirdly and finally given the preceding, no: I think most Americans genuinely don't care anymore beyond that the war ends now, that people stop dying now. Keep in mind that the people who voted for Trump (that includes me) also effectively voted against warhawks like Cheney, Bolton, and so on. The American people want peace, tenuous and unfair as it may be.

As for whether Trump forcing the war to a closure would be for or against the notion of peace: Have no doubt about it, we will be losers coming to the negotiating table in shame and that's regardless whether it's Trump or Harris or even Biden for that matter. Putin won his bet, we had our bluff called and we would be there to try and make the best of the bed we made. But if the war ends, the war ends.
Another way to save money is to rent an apartment and make that your permanent address freshman year than to pay out of state tuition and room and board. I always thought this scheme could never work until I met someone who played it and saved tens of thousands in the process.
How (Not) to Handle Immigration Pushback: Lessons from Singapore and Canada [video]
Oh yes, children, their primary market, definitely consider this. Definitely.
I'm curious as to what you mean by

> as an open protocol, they literally cannot do that.

From a cursory search, it seems the AT Protocol is solely maintained by Bluesky. Also, AFAICT, Bluesky operates the only sizable/relevant servers. i.e. Neither the governance nor the technical operation are decentralized. (edit: Although the OP call for projects includes options which would probably lead to further decentralization, that doesn't speak to the present state.)

Note that I find it reasonably credible that Bluesky won't do that. I just don't see why they cannot. If there is a massive incentive to make backwards-incompatible protocol changes, say a fundamental security flaw, wouldn't the expected outcome be that Bluesky unilaterally makes those changes?
One problem I've noticed with status=progress is that systems can sometimes have gigabytes of buffer space waiting to be filled, so the transfer spends most of its time in a "nearly done" state while (for instance) the SD card gets slowly filled at its real speed.
If you interpret (like i do) AGI as “median human level allweather selfdriving cars”, 2030 sounds a little optimistic even for that.

If AGI is IMO 6/6(/6) 2030 might be even less optimistic but the confidence interval for “Bethlehem*” is wider..

Weeds sounds like shlep without the chutzpah while your former sounds like chutzpah without the shlep?

For the optimum (i.e. “pinnacle”) shall we use the latinate term “panache”? (Or do you have something more victorian)

*the Shoggoth shlepping towards <= welleremembered ~Edwardian poem
Do you ever wonder why mainstream school curriculum doesn't include the discipline most suitable for navigating these waters: philosophy?

And if you do now: do you wonder if this is 100% coincidence, or oversight? How often do you hear the idea even discussed, as compared to, say, how often we hear about "misinformation", and the need for more "critical thinking"?

I am glad this situation has a substantial humorous aspect to it, otherwise I'd probably get stressed out about it.
True but ships and crews with the equipment to do the repairs are limited. It's possible to overwhelm the repair capacities. Also, it takes time to physically travel between cuts so while cuts in the Baltic might take a week or two to fix, a cut in the Atlantic and one in the Baltic may take a week or two just for travel.
Orbit is not a location. Orbit is a group of velocity-location vectors which form a stable loop around a body, without intersecting that body.

Imagine a bullet circling your head at mach 25. Now imagine a second bullet, circling your head at a slightly different angle, at a slightly different distance from your head. There's a chance that they could collide, and the resulting explosion would leave a great deal of dust... on a mixture of velocities, still circling your head. Now add a third bullet, also on a slightly different vector; Make sure that it doesn't collide with any of that dust!

The actual situation is we aren't dealing with 3 bullets or 100 bullets, we have ~170 million objects orbiting the Earth, and only around 50,000 are large enough to track. They are all moving fast enough in relation to each other that a collision would result in a sizable explosion, not an elastic agglomeration. We have no way of removing them.

The good news is that there is a large volume of space for them to exist in. The bad news is that as we continue to fill it up, odds of collisions increase, and every collision spawns many, many more objects.
Claude Computer Use
Buffalo is a city, and therefore probably is profitable for New York State. It's rural and suburban areas that are money pits.
For starters, never commit to a timeline without doing your due diligence. We're not selling carpets. Anyone who gives a time estimate on the spot is setting themselves up for failure.

Second, always pad your estimates. If you have been in the industry longer than 6 months, you'll already know how "off" your estimates can be. Take the actual delivery date, divide that by the estimated date, and that's your multiplier.
Except not everyone is Steve Jobs with billions to do what he wants first.

Nice to imagine maybe.
No, in fact, many rural areas are not economical for farming. But in those areas they may have other extractive industries to support a population.
Reddit's become a propaganda factory, and it's disturbing. Heavily astroturfed subs are creating an echo chamber effect that's clearly damaging users' mental health. The platform's lax security makes it an easy mark for foreign misinformation campaigns. You can still sign up without even an email address!
A week after bankruptcy would have been too late…
This is not a step in the right direction.

Tuition for undergraduate studies should be affordable. Not for a small number of very rich universities that can afford it. But to all universities, as it is in most of the world.
> who bases his theory on 'Putin never lies'.

Can you cite anything that he has actually said that even resembles this?
It's great for development environments or scheduled jobs, the 15 second start up time limits it for most other things I'd imagine. Is it still minimum cost of ~45/month for the lowest instance? I guess this will help that but it would be great if it was priced closer to V1.
?? Shrek[0] option for GNU Poke[1] to highlight different onion layers ala pygments[2]/tree sitter[3] parse style ??

-----

[0] Shrek : https://www.dreamworks.com/movies/shrek

[1] GNU Poke : https://news.ycombinator.com/item?id=26274466

[2] Pygments, generic syntax highligher : https://news.ycombinator.com/item?id=41324901

[3] Treesitter : https://news.ycombinator.com/item?id=39408195
Linux 6.13 Supports Ultra Capacity SD Cards "SDUC" for 2 to 128 TB Storage
It's just a tool I know, I guess if I posted any link you'd say the same thing regardless of the tool.
> disagree with your assessment that the top voted comment doesn’t support it.

Did you read the paper or skim its abstract, figures, and conclusion? I'm not so sure that commenter did, or they may have cited this,

> Because we report smaller cardiomyocytes in cultured cells and in mice treated with semaglutide, it is tempting to speculate that semaglutide may induce cardiac atrophy. However, we do not observe any changes in recognized markers of atrophy such as Murf1 and Atrogin-1. Thus, we cannot be certain that semaglutide induces atrophy per se or if it does, it may occur via molecular pathways that have not been identified herein.

> Building the skill to rapidly come to a preliminarily judgement of a headline is crucial.

You can't judge this paper based on the popsci headline.

> most so-called “science” outside of the hard sciences and mathematics is complete garbage and driven by funding needs

Based on my reading of the figures and conclusion, I don't think you should call this paper garbage.
If they are like most other schools with a low income neighborhood nearby, they probably offer an entire k-12 education sequence for these kids ran under their education major’s department. Likewise their hospital probably treats low income people in the community. And of course the school itself is a massive jobs program for low income people in the area as well, who might qualify for reduced or no cost tuition for themselves or their kids.
The large majority of MIT undergraduates graduate debt free.
I mean yeah, getting your work published just means that you can sue if someone steals it (often the case with those university presidents that they plagiarized work from undergrads or those who otherwise couldn't fight back). But if publishers stop making money off academic texts, then they won't be inclined to fight those battles. Then again, a lot of the money comes from university library subscriptions to entire catalogues of texts including books and articles, so either something you want to access is already in your ecosystem or it isn't.
It sounds like they're just deranking the blog spam posts. In my opinion, Google should derank the whole domain/brand. If you purposely put your name on garbage, we should put your name in the trash.
Funnily enough, if you think about for networking you'd much rather be surrounded by kids who can afford that 200k price tag upfront.
Public wash-house Liverpool (1959) – BFI National Archive [video]
China didn't do it and the USA hasn't withdrawn from anything.
It appeared the writer Indrajit Samarajiva is based in Sri Lanka. The article starts off as academic then ended on an anti-Western/America diatribe which could've been omitted.
Just walking is better. You get a steady burn. If you do high intensity you burn calories for a good while afterwards. Mild intensity doesnt do much.
DHH joining won't help that I suspect
+1. The other concern is that AI is potentially removing junior level jobs that are often a way for people to gain experience before stepping up into positions with more agency and autonomy. Which means in future we will be dealing with the next generation of "AI told me to do this", but "I have no experience to know whether this is good or not", so "let's do it".
pv also allows this, but you have to look up the process id manually, and pass it to the -d flag.
They found the mice did not suffer from any heart problems, so it’s not surprising.
The population of people who apply to a nice college, or even college at all, is probably not representative of the average american household
FAISCO is an interesting viral marketing platform. it guides
followers to participate in the games where they can win prizes, while businesses can gain brand exposure
and interact with their followers.

Key Features:
- Fun Games: Use game templates to generate leads and boost engagement.
- Effortless Creation: Set up marketing campaigns in minutes.
- Diverse Giveaways: From spin-the-wheel to scratch cards, we've got it all.
- Social Media Expansion: Encourage shares and expand your reach.
- Form Collection: Gather user data effortlessly.

Why choose FAISCO?
- Time and Cost Savings: Reduce manual work and operational costs.
- Enhanced Marketing Impact: Diverse tools and insightful analytics.
- Boosted Customer Interaction: Engage and retain your audience effectively.
I think you therefore agree with my reductio ad absurdum argument against the GP's claim. Changing maritime law to prohibit free roaming over "important cables" would be a farce. Therefore, the absence of such a law is not "the issue"
The most reliable source of knowledge we have are in the science. This is further reinforced by technological development that validated the sciences, although at time the technology may precede the science.
> Ever since I became a programmer two decades ago, the great unwashed masses of techno-dweebs who call themselves "programmers" have been picking up complex and nuanced technology that they have never bother to formally learn, and then complain that it sucks and they need an alternative. When in reality, the problem is almost always either a) they didn't read the manual, b) they haven't practiced using it

This kind of Dunning-Kruger-esque arrogance in software is intensely aggravating to me. Nobody presumes that you can master, say, a musical instrument, without intensive practice over a timespan of years; yet for some reason people can get plopped out the other end of a bootcamp and suddenly identify as world class programmers in 16 weeks without the requisite thousands of hours of practice with hands on keyboard, reading the manual, studying how the computer works, and actually solving technical problems.
I find it fascinating that the party that wants to ban porn as indecent is also the party that doesn't want to restrict ai generated images because of free speech. When the two meet, which side wins?
If 800km impacts go asymptotic, it pollutes 700km and 900km orbits by virtue of having a distribution of resulting debris velocity vectors, and as drag pulls down all the resulting debris over the next thousand years, the 800km debris becomes circular 700km debris, and then circular 600km debris, and then circular 500km debris.
Baba booy bbaba booy
Batman bats badly barring the baristers bearing.

Magic schoolbus!

Yea, take that llm model maker