skysight-inc/HackerNews huggingface dataset:
There was some article about it on HN a while ago. If I remember right the problem was that its bioavailability is super low. You can take all you want, but only a tiny percent makes it through to get absorbed. In theory you could increase the the dose a lot but I imagine that might have other issues.
This is beautiful. I wish I knew this eons ago!
I think this is more like introducing and RCE into your body, since CRISPR essentially modifies your executable code?
Often times there’s simply no alternative. When we purchased our current stovetop we didn’t find any with non-touch controls.
Exactly, they called it something else in order to obfuscate the issue. Call it what it is.
> Following President-elect Trump’s victory — which was fueled by male voters

Not sure if I buy the "gender war" framing of the national election. According to the stats in the linked article, there was a modest but not crazy 6% differential in between genders this election cycle, which is closer than it was last election (14%)!
As stated in other comments, it would be actually easy to implement as it doesn't require a change in the constitution.

Anyway, as I told in another comment, I'm not from the US, so my intention wasn't really to say how to implement the proposal. I just had this idea and wrote it down in a blog post.
Insert it’s not q bug, it’s a feature image
NORA Music| Full Stack SWE | United States | Remote | 12-18 hours/week | $32/hour / .3% to .5%

Nora is the IMDB for music, taking everything about your favorite songs and putting it in one place. Post closing our first round, we are speaking with Universal, Sony, and Billboard Top 100 artists on collaboration. We're looking for a talented Full Stack Engineer to help reduce the stress within the music exploration process for musicians.

Requirements
* Extremely detail oriented
* Strong background in music
* Startup experience
* Knowledgable of React, Next.JS, and AWS

Happy to answer any questions, if you love music and SWE apply to us through the link and leave a comment you came from YC HN!

https://wellfound.com/l/2zZLum

Full bio:

Nora functions as a music exploration service, gathering all the information a musician wants about their favorite songs and artists in one place. By consolidating essential information about songs and artists — from the stories behind the music to in-depth credits, chord progressions, and production details — Nora empowers artists by redirecting revenue back to them. Post-closing our first round, we are partnering with major labels such as Universal and Sony and numerous artists (Billboard Top 100) to bring our vision to life. At Nora, we believe music is a journey of creativity, people, and processes, deserving of recognition and monetization that mirrors today’s technological landscape.
Fundamentally a dev owns the code they write - it doesn't matter if it's copy/pasted from search results or filled in via an LLM.
Strongly disagree. There should be a higher standard of articles. This amateur "look what I can do" is just noise. Here's an idea, don't tell the world about what you've done unless it is something new. We don't care and it wastes our time and fills the internet with shit. Not everyone deserves a medal for pooping.
Why Alpine is the new jQuery
So then it should be called "Popular Vote" and not "Interstate Compact". It just obfuscates the issue.
ScholarlyArticle: "Gene editing of NCF1 loci is associated with homologous recombination and chromosomal rearrangements" (2024) https://www.nature.com/articles/s42003-024-06959-z
Seconded. Been daily driving it on ThinkPads now for something like two years. I will never go back, and one of the few things which might draw me off Qubes OS is if OpenBSD cleanroom reimplemented Qubes OS with their own OS and hypervisor. (OpenBSD because nobody beats their long term code quality and consistency.)
I do not know much about the internal workings of Windows, but why is this not implemented as a system wide action? Are they really implementing "AI Tools" in every application that uses text... individually?

If this was in the context menu, along with Cut, Copy and Paste, you would be getting AI integration for free on every application that renders a text box widget.

I mean... spell check is implemented like that right? They seem to be pitching this as a way to correct or improve text so why not build on that?

I'm not even a fan of this sort of generative AI "type whatever" tool, or I at least find it to normally be inadequate. But if they're going to do this AI pivot in Windows anyway, the choice of implementation here seems short sighted.
In line with the other reply, it's simply a matter of cause and effect. If you are unable to come to terms with cause and effect, then you are the closed minded one.

For example, if you remove low-cost PrEP more homosexuals WILL get HIV. WILL. Not might. Not may. WILL. It is really that simple.

Okay, so therefore if you have policy, which many conservatives do, that insurance should not be mandated to provide affordable PrEP than you MUST support more homosexuals getting HIV.

The problem here is people are cowards and weasels. They support things, knowing full well of the consequences of it, and then will proclaim they don't support the consequences. That's impossible, it doesn't work that way. That's true closed-mindedness.

If I support adding bottomless pits all over the road, then I support some drivers diving in them. That's how the world works, cause and effect, and even small children learn this quickly. It's only when the adults start to weasel that there's room for "debate".

I would have much more tolerance for conservative opinions if they would just outright say they want more homosexuals to get HIV, as a punishment. Or say they want more women to die. But they don't, because they're cowards before conservatives. I cannot respect a coward.
Texas has publicly available lists of who voted. https://earlyvoting.texas-election.com/Elections/getElection...

Seems like other states have similar info, but you do need to request it and in some states you have to pay.

I thought about compiling all of the data and then cross correlating it with the results, but I think Im going to spend my time learning German instead, just in case.
One of the devices was stored in a Faraday cage in airplane mode[1] - there's literally nothing to monitor

[1]https://appleinsider.com/articles/24/11/07/iphones-stored-fo...
Does it matter which CRISPR or CRISPR-like method is applied; or is there in general a dynamic response to gene editing in DNA/RNA?
Airbnb rentals linked to increased crime rates in London neighbourhoods
I would think that the secure enclave controls the device (un-)locking process and also wouldn't install OTA firmware updates nor accept commands from USB-connected peripherals while the device is locked.
The 4B people don't seem to know about the Men Going Their Own Way (MGTOW) people.

Many single men have given up on the whole dating scene.
WGTOW's see 4B's as win for them.
> sometimes I literally can’t pay to watch it.

Yup. Top 2 reasons I became a pirate again after not being a pirate since maybe 15 years ago:

#1 I literally couldn't give someone money to watch/listen to what I wanted

#2 I was paying someone money to watch/listen to something and then they removed it

Even popular things like Saturday Night Live are still impossible to acquire legally in my country.

Edit: Forgot another point that became very annoying, the show is available but not with the subtitles I want and/or need. For example, watching a Swedish TV show on Spanish Netflix doesn't let me have English subtitles for example. But if I use Swedish Netflix, it would work, but technically breaking Netflix's ToS. Content rights have completely fucked up the user experience.
Grammarly is experiencing a service interruption
Most services are down.
Shakti (Microprocessor)
India's antitrust body probe finds Zomato, Swiggy breached antitrust laws
I've used VLC for a long time as well, and while I wouldn't call it crusty, I would call it odd. Powerful, super capable, but doesn't seem to follow standard conventions. Honestly, it's odd but I would rather they don't do some overhaul to standardize or modernize it. Software, hardware, etc. don't have to be homogenous or turn into bland corporate-ware.
Aren't the sports generally growing their revenue and audiences? It seems the reason for the multicolored jerseys, gambling ads, etc. is you: 'You' (most people reading this) keep watching, no matter what.
It's funny that this phrase has had such staying strength, while the key word in it, "powerhouse," has fallen out of fashion. The more modern American English way to phrase it would be "the power plant of the cell."
Quite offtopic, but when and where will I write this otherwise?

Just the other day (like a month ago) I decided to read this book, just to see what the hype is about (I'm living my "let's read some classics and stuff" era). So I grabbed it, started to read it... and literally it took me 2 hours to reach page 15. Okay, I'm not a native speaker, but I haven't had any problems reading any books in English in the past decade+. And this was just unreadable - literally, I was unable to read it. Its vocabulary and sentence structure is just out of this world.

I gave up on it.
True, I'm OK with an alternate, including the City Connect uniform for a few teams, that's basically a throwback uniform. Milwaukee's is kind of like that, at least with the colors. Also Atlanta's, Pittsburgh's, and Seattle's. The rest of them... no.
You are right, I forgot the mess that is React Router. I was so sick and tired of router churn when I was heavy into react, it is sad to see it hasn't gotten any better.

The situation with React Native back when I was doing RN was horrible. I ended up with 2 major breaking changes to the main router package, and I burned so many weeks of time trying to keep up to date with routing changes. It is super annoying that such a simple thing has so much churn. The solution doesn't have to be perfect, it just has to be good enough, with well documented warts and workarounds, and lots of sample code!
It's interesting to look at this list, because it feels like a lot of Trump supporters concerns about Trump are the same as the liberal concerns about Trump.

I 100% do not think that all Trump supporter's are _blank_ I think most are good people concerned about their family / living situation / community etc.

But, in a liberal free speech environment, how do you get people to not get the message that "all white men have privilege", or "All Trump supporters are Nazi's". I'm not going to say liberals have no fault here, but the conservative media's fear mongering about say Trans People far exceeds the amount that democrat politicians talk about trans rights.

I don't think that even most liberal women believe that men are more dangerous than a bear, but man that message went viral as shit.
Obviously you just put the nuclear material inside of the in-flight data recorder so it will survive a rocket failure.

If you're being serious, Cassini had those kinds of questions with its launch about its RTG but that didn't have enough nuclear material for it to be a problem.

If we were to try and use a fusion reaction in space, we'd probably use the existing one.
Totally understandable. Personally I don't use Bluesky for anything vital, it's just data that the world wouldn't be better/worse without anyways, so I'm gonna go and give it a try even if there is no undo.

I love that people even has the choice, so much better than not even being able to.
Alive != sentient
Vercel Edge is Cloudflare Workers. This is interesting because there are relatively few providers that are running a proper runtime for generic JS functions at the edge. Cloudflare, Deno Deploy, Fastly, Wasmer.
I have an acre of forest and I spend time removing invasive species like buckthorn and wild mustard to keep the forest healthy. It can be really challenging to discriminate between native and invasive plants without a lot of experience and plant identifying apps like iNaturalist. I would love to be able to sweep my phone around and have it highlight invasive plants live. Is anyone working on something like this? The technology already works in images of a single plant, I just need to identify multiple plants in one frame, and ideally live video.
The mitochondria and their dysfunction are likely the basis of most aspects of aging, so an intensive interest in them is understandable.
They also won the electoral college. You have to ask yourself which party has a higher likelihood of winning the popular vote while losing the electoral college.
Jesus Christ almighty give me a site I can use if you want me to absorb your content.

I'm not using a screen reader, I have javascript enabled, I have up to date chrome, yet somehow I can't navigate your artsy site. What do you think your non-standard navigation is adding that is worth the cost of pissing users off?

What do I click on? Where's the content? Why am I guessing how to use your site? Actually, I'm done guessing and clicking the back button to get off this horrible thing.
Well, phenylephrine is ineffective when used incorrectly. You're supposed to grind the pill and snort it. Works much better ;-D
I don’t understand the headline (yes I skimmed the article). Why would mitochondria not be alive? What does that even mean?
# 3 There was 1 subscription streaming service to pay for, then 2, then 3, then 4… and eventually I decided to stop counting but the number kept on going up.
No, it looks like this is their own.
I love Go's syntax. If you hate it, please use a different language. Diversity is good, monocultures are bad.
How would you ensure that all fifty states adopt this approach at the same time?
Application notes can be pretty informative. Also ARRL handbook
> benefit of keeping my project's dependencies much lighter

This seems like pointless exercise.
Wow, wonderful! Love the rendition of "Jupiter". Really a delightful experience.

On mobile, I'd prefer movement on the left, and inventory on the right.
Coffee seems to now be group 3, but your point stands. 2B is meaningless as a consumer guidance.
One thing to consider is that the electoral college system also accounts for varying levels of economic density.

While I often hear “land doesn’t vote”, people don’t consider that a farm will never have the same economic output as an office building with the same footprint. This includes the population that comes with all that employment. There needs to be a way to represent the less economically dense sectors of the country because otherwise cities will dominate everything.
Three Django Wishes
Some Amaranthus species are used in India too, as foods. The grains are used to make laddus (sweet balls made by mixing the grains which sugar or jaggery) and the leaves are eaten as cooked greens with spices, masala, onions, etc. Both are quite tasty.

https://www.google.com/search?q=rajgira
Wasn't that literally the plot of Breaking Bad? Walt's meth was p2p meth.
Awesome! I signed up for the BlackBerry PlayBook dev initiative at SXSW in 2012 and found the device and QNX to be amazing. It supported a bluetooth mouse YEARS before the iPad! But BB failed to capitalize and yet another great product failed to make it into the mainstream.

Looking forward to it! Espcially now that you guys are "inside" several EVs if the rumors are true. Sign me up!
Buying Ralink was also a hella good move. Founded in Cupertino California in 2001, made pretty solid wifi chipsets, sold to MediaTek 2011. https://corp.mediatek.com/news-events/press-releases/mediate...

The scope of mergers & acquisitions in semiconductors is mind boggling & terrifying. It feels like there's so much less diversity, that there's a frailty of entirely Too Big To Fail players left.
Hey pfraze, forgive my ignorance but what role does DID serve that DNS doesn't? My favorite part about bsky is using TXT record to prove that I control my domain for username purposes, what's the downside to just generating a keypair, and using the fingerprint of the public key as my identity? (Maybe with some affordance for key rotation vis a vis KERI*) Not doubting youall weighed every possibility, just wondering what I'm missing

*Key Event Receipt Infrastructure
> If one considers bacteria as living entities — and all biologists seem to — then it is impossible to explain why mitochondria are not.

There seems to be a strange, half-hubris, half-pride vein that runs through Humanity that would see us as lesser for being hosts to benevolent bacteria, despite us very obviously being unable to survive without benevolent bacteria.
"In the early 19th century, "

With that level of proofreading, I'm not sure what else was wrong in the article...
I'm the author of the repo, your comment seems to paint a false picture of linux syscalls being "very easy" to decipher from their names, filesystem calls like readlink, mkdir, and chmod are unfortunately the exception and not the rule. A syscall which I consider one of the more simple syscalls and I'd point you towards is `madvise` whose action can be customized with over 18 different flags, some of these flags create effects, and some of them have a `dispelling` effect and their purpose is not that obvious from the name.

More complicated syscalls range from semi-decipherable with experience to entirely indecipherable, those syscalls will have arguments that can be a numbers/NULL/a pointer/the number -1, each with its own interpretation rules, some syscalls even have arguments that can be both a pointer or a numeric (int) depending on some other flag in a different argument, some syscalls have their entire logic encoded within multi-level structs like the `sigaction` syscall.

the value that can be derived from something like intentrace becomes apparent when you consider that a lot of programmers don't want to peruse the man pages and in the same time want to wield the power of strace, it allows programmers of every walk to be able to skim a strace-like feed very fast obtaining the optimal amount of information needed to know "what wen't wrong", "how does this binary work", etc..
In America maybe :). I only know it from the movie.

Ps wasn't he the same guy that did the "Welcome to Noviephone, brought to you by the New York Times!" Thing? I always called that to test if international calls were working :)
And it doesn't need to be the mail room (though that's not a bad thing to have exposure to, perhaps, but circumstances will determine what's appropriate). The most important thing is not to put them in a position that harms[0] the company and that they're not (at least not yet) qualified for. This is not only bad for the company, but for the child, as they are not put a position that allows them to grow, but one in which they can't help but fail in. So it's a failure of parenting.

[0] "Harm" doesn't need to be catastrophic. Misuse of company funds is a kind of theft, and paying someone a salary who is basically on perpetual holiday is unjust, for example.
I agree, but I also appreciate this because missing map/filter/reduce is probably my biggest pain point when writing Go. Nested for loops and explicit filters are so ugly and hard to read, for me that alone undoes any of the appeal of the language's "simplicity".
> If you're American living in one of the majority of states that aren't "swing" states, I don't think you can escape the feeling when you vote for president that you're going through a kind of charade since the winner is going to be determined by some small number of voters in 6 states.

I don't get the repeating of this perspective, didn't he win the popular vote this time? How did "small number of voters in 6 states" affect this reality?

Isn't winning the electoral college but not the popular vote a statistical minor occurrence? People don't know how to lose.
hahah for sure, I definitely went on the conservative side with a lighter battery so it could nicely be part of the pouch. The upside is because it's kinda "modular" (thanks to Anderson Powerpole) I could attach a much larger battery, and its life is easily extended with the panel I have and charge controller. I haven't actually gone out in the field yet with the solar panel, only used at home, but still! I was definitely keeping its "vehicle-deployability" in mind while putting it together.
Make sense. You are indeed Opinion leader of your opinions and Thought leader of your thoughts.
If this were social media I would just screenshot it for you. There are also people posting more I guess, substantial criticisms of Project 2025, for example. I'm not sure what you're after, but my point is merely to relay the rhetoric. I'm only trying to reflect the climate, which should be easy enough to infer. Another thing I would cross reference this article and the zeitgeist with would be the Kinsey Report. Sex maniacs everywhere! This is just how humans are! Well, yeah, with that sample set. I'll stop short of any potential implications of Kinsey, et al, or asking 'why is so much of it free?' which might introduce analogies to vice or drug pushing, etc, and therefore intentional subversion. Whatever consenting adults want to do with themselves or each other is up to them, IMHO. However I think it's silly to talk past people with traditional values. I sincerely hope it isn't 'a tell' to call them fascists for simply not wanting their kids exposed to hypersexuality, etc. We had that happen once in society already and it didn't end well for my people.
A friend works at an english football (soccer) club on the sponsorships team and yes money is definitely a big driver here!

Part of it is creating more sponsorship inventory - some brands can opt in for space on one of the jerseys that fit their budgets over others, or play around with sizing.
Completely different meaning of embedded, this is about putting the generated C code in your program, not putting the interpreter in your program.
Amber Heard ruined that word for me.
"self host an entire copy of all user data" is a pretty cool capability to have, kind of proof that the infrastructure is really open and forkable. you seem to have misunderstood OPs goals. Serving your own data from a personal data server is a much less arduous affair.
'The Magic Mountain' saved my life
https://archive.ph/oCen3

'The Magic Mountain' [1924]

https://static1.squarespace.com/static/5e265eb50aee2d7e8a81a...
That shouldn’t be happening. Do you fill both soap dispensers? Check out the video in a sibling comment.
For a fictional macro version of the Margulis hypothesis, I'd recommend 'Alien Clay' by Adrian Tchaikovsky
Show HN: Tuki – A GitOps tool for safely running one-off commands in production
Tuki is a small, open-source utility that lets you run one-off commands in production through Git, bringing version control and code review to production scripts. I built it after accidentally dropping a production table due to a console typo

Key features:
- Run scripts through Git PRs instead of direct console access
- Built-in auditing via Git history
- RBAC through standard Git permissions
- Simple setup for non-Kubernetes environments
- MIT licensed

Demo & more details: https://github.com/hundredwatt/tuki
Announcement blog post: https://nochlin.com/blog/introducing-tuki

Would love feedback from the HN community!
Yeah, it's so frustrating. There's the "opposite" problem too where old software I had is no longer on App Store, and simply cannot run on newer versions of iOS. I finally had to say goodbye to my friend's awesome photography app that applied a really nice B&W effect which was unique to that app. I'll never be able to use it again, unless I carry around an old/outdated iPhone with me.
Gymnastics rings are one of the best things I've bought lately. I already had gym equipment at home but rings are something else.

Once you try them you realize you're not strong enough and you have a lot to do. And I also feel the workout is different because it's me training on the rings, not me lifting something heavy. They are very versatile, you can do many exercises anywhere you want.
where can I buy new these f&*(( headphones