skysight-inc/HackerNews huggingface dataset:
HPV causes multiple lesions in humans, including warts.

Certain types of HPV are more associated with certain lesions over others, but the broad range of HPV targets means that dangerous HPV types could be transmitted through relatively innocuous means.

Some context: https://www.ncbi.nlm.nih.gov/books/NBK448132/
I got completely stuck in the Beavis and Butthead adventure game when one of the voice acted characters told me to get a "vee-hickul". As a teenager sitting at my family PC in London, I had no idea what the hell the Texan (?) was saying. Only several years later would I figure it out.

The only other thing I remember from that game is the hock-a-loogie minigame, which I mastered. I wonder if my parents had any idea what I was up to on the computer?
I agree with you in general, but this part is off:

> which is low since that 500k isn't cash comp and you wait for long term capital gains to kick in

Stock that a company gives you as compensation is treated as ordinary income at the time it vests, based on the value when it vests. If your total comp is $250k salary + $1M in stock over four years, and the stock value stays flat, your taxes are the same as if you got $500k in salary each year (a bit worse, actually, because of the first year vesting all at once making your income $250k and then $750k); if it doubles the day after your grant and stays flat after that, your taxes are the same as if you got $750k in salary each year. Long-term capital gains only apply to increases in stock value after it vests - not any different than if you sold your company stock immediately and bought another stock.
* HN users who don’t block analytics
Does possessing specialized knowledge or skills alter the ethical landscape of medical decisions?

In other words, should someone with the capacity to administer an experimental treatment be held to a different standard than those without such expertise?

Let’s say an individual opts for a less effective or accessible treatment due to personal limitations or lack of knowledge: does this alter the ethical weight of their decision?

This question becomes more complex when treatments have varying degrees of risk and benefit.

If a treatment is simply an off-label, it often goes totally unnoticed unless it carries an unacceptable risk.

Under that condition, what happens when the treatment holds significant promise, potentially offering a curative outcome? But it doesn’t yet have medical trials? Does the prospect of a cure override the ethical concerns about its risks? Where is that line?

When faced with a life-threatening disease like recurring cancer, what is the individual’s responsibility to society in considering the ethics of self-treatment? Should she have accepted less effective therapy that had already lead to a failure condition for the good of the rest of us even though we are barely effected?

How do the potential benefits to the individual—such as survival—contrast with the potential societal harm, if any, in terms of bypassing established protocols or ignoring sanctioned research?

At what point does the line blur between personal medical autonomy and the ethical implications of self-administered treatments?

I really do wonder about these questions. I mean, the only difference between the ‘ivermectin cures cancer’ et al crowd and this lady is her degree of knowledge, so how do we deal with this ethically?
You are comparing invalid syntax to a purely cosmetic temporary non-issue.
I've been using Delta for a few years now and absolutely love it. Huge improvement to my command line diff viewing!
Unless you ship all the fuel you need to have on Mars while you are there and to get back (expensive), you'd need some technology to capture CO2 from the Martian atmosphere and combine it with hydrogen (from electrolysis) to make methane. But once you have that capture technology working there, it doesn't seem like there would be a problem with running that technology on Earth. If it were possible to capture CO2 directly from the air (DAC), you'd be cutting down the amount of CO2 in the atmosphere that is only there because we burn fossile fuels.
Arc+Mac

why default to small text?
MTProto is the protocol used for secure chats, that is the name of their E2E encryption..

If you do not enable E2E it will not use MTProto and not have E2E encryption.

And all of this is only available for private chats, none is available for groups chats..
I can't speak for the OP, but in my country we have several parties, so I can express my political opinions in a more complex way than the left-right linear spectrum. The parties don't position themselves by just being "more left" and "more right", but tend to cater to a specific audience. For example, we have many LGBT issues, and I can vote for a party that spends a significant part of their political power on improving the situation. If I wanted to focus on economy, there's a party who I'm mostly aligned with, but unfortunately I don't like their conservative and even far-right tendencies, so I prefer another, more populist and pro-social but still solid party. There are some parties which are completely not for me, but which cater to, for example, farmers and have a significant following in rural population (they're slightly conservative, but pro-social and have nothing to do with far right, just to give you an idea of the differences). And yes, we have the mandatory populist party.

I don't have a party that I agree with 100%, but I can decide what is most important for me and vote for a party that wants it. And most importantly, if I don't like my choice, I can vote for another party next year without making a 180.

I think that's nice.
Rip van Winkle's Razor, a Simple New Estimate for Adaptive Data Analysis (2021)
> There is zero security benefit

I assume you don't work in security. The "HRDN" means it's a Hardening rule, and hardening is the action of reducing the attack surface for possible attacks as much as you can, even for the most crazy types, like a normal user or malware having access to download an exploit from exploit-db.com and being able to compile it without being root.
I'm about the same age but personally I had the opposite experience. For me it was refreshing to play something more mature, more 'intellectual', even if I'm sure a lot of the jokes washed over me.
Since tree sitter parsers output a c library, you could dynamically load it.

The rust bindings themselves are a thin ffi wrapper.

If you wanted to make it a little smoother than needing to compile the tree sitter syntax you could compile/bundle grammars up with wasm so its sandboxed and cross platform

Edit: found this vscode extension that dynamically loads syntaxes compiled to wasm. You should be able to do the same thing in rust: https://github.com/selfint/vscode-tree-sitter
Even then you need a fairly large transmitter. It is quite easy to detect EM transmissions even when they are low energy. This would be incredibly easy to detect. There are plenty of regulations already by FCC, ITU and equivalent on what is allowed on what wavelength which most nations are signatories too.

Violating these is already solved by law enforcement, even if a rogue nation state is protecting you it will be handled with big gun diplomacy, America after all has the biggest guns.

As xkcd put it, $5 wrench is all it takes no matter how strong your encryption, that works both ways, if a government can find a malicious actor all it takes is $5 wrench to stop you. There is limited value for nation state to protect you from hacking voyager, there is no military or strategic value in it. Dormant satellites in LEO or GEO can be used as kinetic weapons so are lot more valuable.

There are also tech solutions like active jamming that could easily be deployed to counteract you that civilized world can use first even if they don't/can't blow you up without risking retaliation from your state sponsor.
I had a 6-hour surgery a few years ago, for which I was unconscious. When I awoke, my butt hurt (that’s not where the surgery was) such that it was difficult to sit on hard chairs for 3 or 4 days. It was explained to me that although I was unconscious, my body still knew what was going on and was tensing up during the surgery. I thought it was interesting that my body had trauma from an event that my brain couldn’t remember.
Did you use WAL mode and BEGIN IMMEDIATE TRANSACTION?
The truly hilarious thing is that the Tokyo subway system actually suffered a terrorist attack in 95, and still they publish the locations of all 200+ exits from Shinjuku station.
>School districts and the like have them, it's not at all locked down.

I read the article about school districts obtaining Cellebrite devices, but I don't think that really refutes what I'm saying. If it was that easy, why wouldn't we see more in-depth analysis of the exploits that UFEDs use?

Other than the Moxie Marlinspike post, I haven't heard of anything recently. Would love to learn more about this topic.
To open the BBB, I believe you either need (1) microbubbles or (2) much higher pressures than what we'd use.

Ref: https://pmc.ncbi.nlm.nih.gov/articles/PMC9029131/
I'm very curious, from the perspective that you have based on your experience at the retreat, what it means to you when you talk about "processing" these traumas?

Maybe a very concrete way to ask would be: what's the difference between someone who undergoes the ayahuasca experience and successfully "processes" a trauma, vs someone who does not? Is there such a thing?
> developmental bioelectricity

Probably already aware of methods like:

- Tissue Nanotransfection : https://en.wikipedia.org/wiki/Tissue_nanotransfection

- "Direct neuronal reprogramming by temporal identity factors" (2023) https://www.pnas.org/doi/10.1073/pnas.2122168120#abstract

... https://news.ycombinator.com/item?id=36912925
It would be super cool to do some sort of energy harvesting when you move the calipers open and closed.
You're confusing hatred with objectivity.

Oligarchs aren't subtle or even interesting. It's remarkable how blind people are to the obvious.
Let her do what she wants to herself. So many words spent waffling on something so simple
It used to be a lot easier to get a law degree. California is currently the only state that will let you sit for the bar without a JD. You have to have equivalent work experience but you can still as a completely private citizen get yourself into practice.

Industrial gatekeeping is a real problem. One of the indirect mechanisms is the accumulated complexity of the law and the seeming inability for legislatures to remove outdated and fruitless laws from their books. Unsurprisingly the people most capable of achieving this are not interested in doing it.
Interesting. A few comments.

The Banks billboard brought back memories. My mom used to work in the computer department (or whatever they called their IT center) at Banks D.I.H. when I was a kid. I remember playing with used punch cards and having bags of confetti from the punched out chads.

The slavery discussion brought out a LOL because it was almost exactly what I was taught as a Guyanese schoolkid in the 70's. Especially the part about the Amerindians basically saying, "fuck this shit" and disappearing back into the jungle.

Having lived in the US for over 40 years, I have essentially no connection to the country of my birth any longer (technically I was born in British Guiana, but whatever), so it was interesting to see how it's changed from what I remember. Captions on the photos would have been nice though.
> the closed nature of the platform (despite it being a linux OS) makes it less appealing.

Seriously, I really hope some management and/or devs from Remarkable are seeing this. I want to shout it from the roof tops. I bought a Remarkable 2, and I would definitely be buying a Paper Pro, if it were a little more open. I'm appreciative that the device itself isn't locked down (that was enough to sell me a RM2!), but for the kind of money Paper Pro costs I need more out of it. If it was a very open system (like in my wildest dream, all software for it would be fully open source) I would take the plunge. As it stands, I'm leaning more toward the Daylight as it seems more hackable to me. I don't need much, not even a big ecosystem, just the ability to hack on it and/or install homebrew stuff from others. The ability to automate and/or easily run scripts on it would be killer.

Please Remarkable, embrace the spirit of openness that I know burns within you. It's a little hidden by conflicting business needs, but I know it's still there! Let those feelings be free, and create the masterpiece that you and I both really want.
Show HN: Dracan – Open-source, 1:1 proxy with simple filtering/validation config
If you are tired of using Apache or Nginx to proxy your app and implement validation or limiting you may be interested in this hobbyist project. Thanks for all feedback.
They aren't having offspring. Cooperation with people that hate you does not result in offspring. If the system makes it impossible for the average man to start a family, expect chaos.

>You can be mad about it all you want

They will be. Millions of them.
It's randomized.
I really like this approach. Building for WASM directly, rather than trying to also directly generate binaries, means you can rely on WASM GC and the async support that (I think?) is supposed to be part of WASI 0.3.
DNA shows Pompeii's dead aren't who we thought they were
I'm Russian, I used to be a programmer at an accredited company, and I still wouldn't be safe from the draft because I have no university education. (For me personally this is a moot point because I left Russia, but still.)
I think the Taylor Swift example is more awkward - to have an award named after you and then given to you and never given to anyone else!
It's similarly expensive here in Singapore, so I got just one dose.

Some studies have suggested that even one dose of Gardasil 9 is enough:

https://www.thelancet.com/journals/langlo/article/PIIS2214-1...

https://pmc.ncbi.nlm.nih.gov/articles/PMC7455166/

https://pmc.ncbi.nlm.nih.gov/articles/PMC10480621/
Funny enough the foot was restandardized to .3048m in 1959. So it is a metric-derived unit. Before that it was a feifdom unit, set by kings.
I recently got the HPV vaccine (along with some other vaccines I didn't get as a child of anti vax parents).

Vaccines are one of the most amazing inventions. The fact that they can eradicate entire categories of diseases and save so many people from suffering and death with such a simple intervention, is truly remarkable.

It makes me very sad that as a society we are failing to simply take what's there. Maybe the biggest flaw of vaccines is that they are so effective that people don't remember how bad these diseases really were, and only know the minor side effects.

Feeling bad for a couple of days instead of getting certain cancers, measles, hepatitis, and many other serious diseases is a great fucking deal. Also had almost no side effects from the hpv vaccine, 10/10 do recommend.
>Because perverts are few?
Yes, now you understand why it's so annoying and offensive. Women will fly off the handle and accuse any man they don't like of being sexually dangerous when the vast majority of men are just going about their life. It's extremely banal.
I have met two other Guyanese people in the US outside of friends of my family. One of them was actually someone I was friends with in Guyana. Purely by coincidence we went to the same US high school and came across each other in a hallway. The other had moved here when he was about 2 years old.

Shouldn't be surprised. It's a country the size of England with the population of a large neighborhood in Brooklyn.
Does space race say anything to you? One way of winning a race is to become faster, another is to make others slower. You know sabotage isn't just spy novel stuff.
Am I tired or dumb? I know all the words but I have no idea what you’re saying. I can’t pick any two consecutive rows of text in your message that I understand.
> They require a bar that is impossible to prove in real life.

Hardly. Discovery is an amazingly powerful tool. The problem seems to be most of these cases are argued in front of bench trials and not jury trials. Judges are often swayed by technocratic arguments and can be easily convinced to ignore the impact of monopolies on labor markets in favor of the simple consumer pricing argument.

> and allow a lot more power to split up and fine large companies

We already have that power. You might ask why the DOJ has refused to use it in the past two decades.
To give a bit more context to protomolecule's replies: back in 2022 every analyst was predicting total collapse of the Russian economy within a year or thereabouts. This didn't happen. So, we now tend not to believe the doomsayers at all. (And I'm not saying we're right! Just trying to explain the biases in play right now.)
Yall are missing the point and reading what you want to read. I am quite aware of the perspective. There are people on the streets in my city because the median income is $70k and the median house is $1.5M. They are thoroughly screwed by the system. My point is not to garner sympathy for the top earners. My point is that almost all of us are earning far below what we should when you look at the grand scheme of things. The war is not between the average man on the street and the average man at a tech company. It's deeper than that.
Someone said to me, if you look at all activities that have the potential to make you vast amounts of money, what you'll find is that the people doing them are people who are very motivated by money. It's not that the good guys at stripe selflessly accept devoting their lives making society better even tho it's boring, they're doing it for the money. I don't see how "smart" or "boring" enters here at all.
Maybe use dayjs to handle all kinds of wired string dates.
You might have chosen a bad example, as both sides had many early warning satellites, and such a catastrophic 'failure' in any tactically significant proportion of them would immediately put both sides on high alert. It would be much more valuable to target individual reconnaissance or communications satellites in order to make a 'blind spot' to support a particularly important secret project, but even this scenario would be scarcely credible.
You right corruption happen in 100% countries at a level or another.

GP says that looking at history, oil in a country soil seems correlated with more corruption.

I a way, you could see oil as a curse. I bet some locals does, I would if I’d face the political, societal and environmental drawbacks without much benefits.
I've certainly given up on the idea that my fellow man is going to make the collective good choice. And this now influences my own decision making going further. I doubt I'm alone.
Every President and Member of Congress for the past 20 years has failed on this account. I think a different lens to view this through would be more useful.
I haven't thought about this in a long time, but as we were leaving Guyana, I remember my paternal grandfather warning me to stay away from the Guyanese in America: "they will just try to pull you down to their level."
> I think that's nice.

Agreed. I like the idea of political pluralism much more than the idea of a so-called "centrist" party.

We do have other parties in the US, such as the Libertarian and Green parties, but our system makes it very difficult for them. They have to fight like crazy for ballot access, they're locked out of news coverage, they don't receive public funding, and they are reviled as "spoilers" by the two major parties.
It shows the main focus is not the technology, but the fact spreadsheets are important and deserve a robust open source alternative.
Graykey, acquired by Magnet Forensics in its merger with Grayshift, is the market to watch here. They’re espousing support for unlocking iOS 18.x

https://www.magnetforensics.com/blog/graykey-supported-mobil...
Small correction, but there are actually four states (CA being one of them) where you can avoid law school by what is called “reading the law”. It entails more or less doing an apprenticeship with a practicing attorney or judge and meeting certain requirements.
That TinyPilot is really cool. It deserves to take off. I'm surprised he's still bootstrapping at this point, because with a product like that, there's a lot more to gain than there is to lose by taking angel and VC money.
Although I have no objection to a "right to try", it is probably not worth spending a lot of time discussing it because of how rare it is that there are no good safe responses to a desperate medical situation, but there is a dangerous one with a decent chance of success.

The two chronically-ill friends I knew who put their chips on a drastic cure ended up dying pretty quickly from the cure. Neither even had a terminal illness, at least not one that would kill them any year soon: they just wanted to stop feeling miserable and to regain the ability to get stuff done.
The new R211 trainsets[1] have digital displays that show this information as well -- they show the upcoming station ahead of time, along with which exit is relative to which car in the train.

[1]: https://en.wikipedia.org/wiki/R211_(New_York_City_Subway_car...
Similarly, this site has subway station layouts for many cities: http://stations.albertguillaumes.cat/
i have never used zig before, but after reading the article i came to the same conclusion. the "problem" (if it is a problem at all, that is) really is that .{} is the syntax for a struct whose type is to be figured out by the compiler, that new users will be unfamiliar with.

i don't know if there are other uses for . and {} that would make this hard to read. if there are, then maybe that's an issue, but otherwise, i don't see that as a problem. it's something to learn.

ideally, each syntax element has only one obvious use. that's not always possible, but as long as the right meaning can easily be inferred from the context, then that's good enough for most cases.
AI groups rush to redesign model testing and create new benchmarks
I think whatever warning is OK with the users who pay them. There's a feedback mechanism there, they get paid more the more customers they have.

I don't know how most mullvad users use it, but I've never used their ovpn configurations, and I use it on client devices and not some network gateway. It's not going to affect me one bit. I've considered using it on some network hardware I have that only supports openvpn to give myself network wide benefits of it, but because I often use it on my clients to change IPs, and otherwise cycle through different servers as needed, haven't made that move yet. So even if I wanted to, I'd probably have to do a custom solution which means I can use wireguard anyway.
Currently. Guyana was also owned by the Dutch a few hundred years ago.
LLMs have reached a point of diminishing returns
Totally agree regarding not extrapolating to 10 MHz.

I had went down a huge rabbit hole to find the source for the 22 dB/cm/MHz paper that everyone quoted. People reference the Diagnostic Ultrasound textbook; that textbook references an old nondigital ultrasound reference book, which finally references a Fry paper from 1977 [1].

It's funny because the Fry paper never explicitly mentions the number 22 dB/cm/MHz. But there was one figure (Figure 12), where if you fit a line through the data in that figure, you get a slope of 23.5 dB/cm/MHz.

Here's a spreadsheet of me fitting the data: https://docs.google.com/spreadsheets/d/1a70svm-zrzp1SQT5v2m_...

But yes, you're totally right that even the Fry paper Figure 12 was only up to 2 MHz, so it's totally not fair to extrapolate to 10 MHz.

[1] https://pubmed.ncbi.nlm.nih.gov/690336/
A/B Test Design: Curated collection of A/B test results from best-in-class apps