skysight-inc/HackerNews huggingface dataset:
That's extremely unlikely. Working with cancer cell lines will not give you cancer - it's non-transmissable. (with the exception of Tasmanian Devils, and one recorded case of maternal -> fetus transmission).

The cancer that he had was clearly his own, as evidenced by the fact that they were able to match up his normal genome with the tumor genome and find the handful of differences that were driving the cancer.

*Full disclosure: I work in the Genome Institute at WashU, where this sequencing was done, and while I did not work on this particular case, this sort of cancer genomics project is what I work on all day long.
I'm not putting it on par with Venezuela and Zimbabwe. I said major economies. Russia is a member of the G8. Neither Venezuela nor Zimbabwe fall within the G7, G8, or G20, as Venezuela is the 34th ranked economy (just ahead of Greece), and Zimbabwe ranks 130th (ahead of Malta and Mongolia).

Russia's peers are India, Canada, Spain, and Australia, 3 of which (CSA) are markedly less corrupt. Even India rates 3.1 to Russia's 2.4.

https://en.wikipedia.org/wiki/G8
https://en.wikipedia.org/wiki/List_of_countries_by_GDP_(nomi...
"This is easy to say as someone who has never managed a product, but I feel silent self-update is table stakes for consumer-facing products at this point."

yes, but no. saying that silent self-update is table stakes is missing the point: table stakes from your users' perspective is "shipping software that doesn't need to be consciously maintained."

whether you ship rarely and get the bugs out before you do, or ship frequently but have automatic upgrades that don't break things, doesn't matter.
If you can't name your product, your consumers will name it for you.
So Linus Torvalds has created two billion-dollar industries in his spare time?
Apple is trying to move the iPad in the same direction as the Macbook and iMac. You don't buy a MacBook Air 14e. You buy a MacBook Air. When you sell it, you sell a 2011 MacBook Air. When you say you bought a new Ford Mustang, people know what you are (generally) talking about (with the occasional "new to me" confusion for good measure).

And, yes, it is confusing, especially since Apple is the one who started it with the iPad 2. Ford also differentiates its models with "2012".
Internet business is conducted in fantasy dollars.
Diet Coda: What Would You Like?
Mixergy Premium is worth subscribing to simply because you know the content will be good and you don't have to wade through a bunch of random startup advice porn to get the good stuff.

I've found it helpful to take notes and try to implement just one or two of the easiest things afterwards. The strategy has worked well and I more than recoup the monthly cost.
And their product.
Random access is the fastest good way to gauge people in an oral exam. My experience as an academic confirms this.
30 Infographics about…Infographics
Maybe you're thinking about the WinRT API, which is different from the Windows RT OS and devices.

There is a clear difference between WinRT and Windows RT.

The original point about the difference in UEFI secure boot between both is correct though.
YOU are the master of the iPad/laptop, not the other way around.
Separate users and user switching is pretty minimal overhead.

Other than admin accounts at work, it's been a few decades since I've shared an account with someone.
No, of course not :). I was thinking more along the lines of a deaf-mute person being able to give a presentation or hold a lecture for people that do not understand sign language.
Clojure and JBoss AS7
After all instagram did something very similar, used VC investment to boost sale price. And it seemed to work very well. Can we expect some surprise news from github? I don't know, but that can sure be one valid reason for raising such money which they clearly don't need to work on the product in it's current form.
Betable: Bringing real gambling to social casino games
So couldn't they have avoided all this by saying it's going into "maintenance mode" or something? Software development history is full of packages that have fallen into bugfix-only status. Sheesh, what a lot of drama.
...and those that have tend to pronounce it gith•ub, which always cracks me up.
If you don't want PG to drive - then why are you applying for YC?

You don't trust him to ask the right questions for HIS understanding. Judging from your blog post, you don't seem to trust his judgement in rejecting you - the only reason you came up with (in your blog) is that your pitch/answers were badly delivered. Maybe they were fine, but you have been rejected for other reasons (e.g. UVP not strong enough, market crowded with strong competition, customer segment too small, ...).

I guess the real value of getting into YC is to get great, personalized advice. (You can get great, non-personalized advice from books or blogs). For that, you need to let your advisers drive. If the need your input at a turn, they will ask you - otherwise let them go wherever they want to. You need to understand why they are driving the way they do. In the end, you can and probably will take a few different turns than them (because you [should] have more domain knowledge). But by understanding where they would want to drive, you learn a lot from them.

You may ask yourself, why PG was driving the interview the way he was. Maybe because he questions your UNIQUE VP (So what is Rocketr?), thinks there is strong competition solving this problem already (So it’s like a wiki?), or that your customer segment is too small (Who needs what you’re making?). Maybe because of completely different reasons.

Comparing your two answers for "Who needs what you’re making?", it is the same content, but wrapped differently. While there is definitively value in making your message as clear as it can be, I think a good adviser will be able to get to the content. And then give you the same advice, no matter how the content was wrapped.

Think about it: Would you really want to take advice from someone who would reject you with the first answer, but not with the second answer? I wouldn't.

Anyway, good write-up nevertheless. I still think it is worthwhile to try to make a message as clear and easy to understand as possible.
And how is that different from the "yellow journalism" of the late nineteenth and early twentieth century? If anything, the situation is a lot better now since the barriers around publishing are much much lower than they were back then. I fail to see how Ariana Huffington is any worse at journalism than Pulitzer, Hearst, or, say, Murdoch.
The product market for enterprise VCS/SCM is also quite a bit different. It's no longer enough to make it easy for developers; you need to be able to provide better access controls/security and start managing the code lifecycle.

Github has quite a bit of work ahead of them to be on par with say IBM/Rational ClearCase/ClearQuest or CA Software Change Manager (aka Harvest). Definitely wish them luck.
I find it fascinating how little attention this huge branding mistake has gotten. It was extraordinarily amateurish on the part of Apple, the kind of mistake I would have expected from Microsoft a few years ago. Except had Microsoft made that mistake, they would have been properly ridiculed for it.
Don't understand why they are running this today, this news is at least several months old.
> The Xbox 360 also does constant updates that need a reboot.

however, unlike the PS3, 360 updates tend to take 30 seconds to a minute, except for big things like the NXE and the whatever-the-newest-Dashboard-thing-is-called; PS3 updates can take anywhere from 30 seconds to an hour and a half (literally, that's how long it took my PS3 to patch out-of-box the first time I started it.)

again, even if you're doing the same thing as your competitors, there is a lot of space to do it poorly. :)
From the first bug linked from the article (at https://bugzilla.mozilla.org/show_bug.cgi?id=762302):

The CSS Working Group has agreed to give the go-ahead to browser implementers to unprefix CSS3 Transitions, Transforms, and Animations:

http://lists.w3.org/Archives/Public/www-style/2012Jun/0105.html

So contrary to your comments, they're doing this because the W3 said that it's time to do so.
Most of 23andMe's customers don't really get sequencing. They get genotyped on a SNP chip, which only tells you about a million or so positions (out of ~3.2 billion).

The other product that 23andMe is starting to offer is exome sequencing, where they analyze just the coding regions of the genome (around 1% of the total content). This sort of analysis can be enormously useful and can provide much information, but will miss variations in non-coding regions. It also has limited ability to detect structural variations, where a chunk of DNA gets moved around, deleted, or duplicated.

What they did here was whole genome analysis, coupled with sequencing the RNA products of gene expression. This turned out to be enormously important, because the main driver of his cancer turned out to be over-expression of a gene.
How often do people use the Task Manager? I keep hearing about how great it is in every Windows 8 review.
Whenever anyone lists the new copy dialog as one of the top features of Windows 8, it really makes Windows 8 sound bad.

I mean, seriously? The copy dialog? The thing whose job it is to say "OK, you've got plenty of time, go take a shower" and "OK, we're almost there!"

I'm sorry, this is not a key piece of infrastructure. If that's one of the most exciting things you can point to on Windows 8, that says to me there's not much exciting to point to.
I use Sequoia (http://pro.magix.com/en/sequoia/overview.527.html) and I'm very happy with the 'Save Project Copy' function. When I start a new project, I create a 'history' folder and the project copies go in there, named as project_name-timestamp.VIP. I do that every time I'm a stopping point, much like how I use 'git commit' on a code project.

That doesn't mean there isn't huge room for improvement in this arena. An approach like this (or OSX's versions) doesn't allow you to do anything like 'git diff' to see what's changed from version to version. I can imagine this is a very difficult problem for binary data, however. Also, distributed version control on media production software could allow for multiple users to be editing a project simultaneously.

Unfortunately, I don't really see GitHub being able to help much here. For example, any work done to make ProTools files git-friendly wouldn't also work on Photoshop files. I'd love to be wrong about this, but I suspect seeing version control in media production software would require redesigning the application's file format from the ground up, and would be a task for each software company to do on their own.
Change in general is bad for non-power users short term. Especially now that the interfaces grew less similar to the old windows paradigm it will get harder to steal the theoretical people escaping the Metro UI.

I have personally not formed any opinion if Unity and Gnome Shell are good or not. I have used them too little to say, I primarily use XFCE myself which was very easy to get started with.
Was surprised not to see this on the front page. This is pretty big news:

"Today, the company has received an undisclosed amount of money from 25 investors including Greylock Discovery Fund, FF Angel LLC, True Ventures, Dave Morin (ex-Facebook employee and current founder of Path) and Yuri Milner, the Russian investor who took big stakes in Facebook and Zynga. Those are big-name supporters who believe that Betable has a shot at raising the average revenue per user and average customer lifetime value for social games.

Among the other investors are CrunchFund (Michael Arrington’s fund), Marc Abramowitz (first investor in Palantir), Scott Belsky (founder of Behance), Auren Hoffman (founder of Rapleaf), Sean Knapp (founder of Ooyala), Howard Lindzon (founder of Stocktwits), Matt Ocko (angel investor in Zynga), Joshua Schacter (founder of delicious), and Arjun Sethi (former CEO of Lolapps)."
Well... a tweet saying "I saved space with some app" is probably not any less valuable to your followers than one saying "Mmmmm... fried cheese... [insert instagram pic here]". I see a lot more useless food tweets than I do contest tweets.

Edit: full disclosure... I frequently tweet food pics and almost never tweet content entries. :)
Russian Wikipedia blackout
Well, unless you get one of the RT tablets.
Please, make our life better and bulid this
you know, i love to use the keyboard - on another side i use chrome and have a lot of bookmark folders so when bookmarking page i use
Ctrl+D / Cmd +D - but you have to choose the folder ,right - and that is so boring (and sometimes the folder won't be in the list and you have to click "choose another folder" and that open new window and pla pla pla)- why if i have folder called ruby and the title of the page i bookmarking called "10 Useful Tips For Ruby Developers" why chrome doesn't understand that and ---- you know ---- ,so please i you can build an extension can do this please build it
It's in their interest that you walk past things you might need to trigger spontaneous purchases, I agree. But it's not so clear to me that they really want you wandering and frustrated. Note that most stores label aisles clearly, keep things in the same place for long periods, and often provide ways to find things yourself (staff, phones, mobile apps, paper maps).
Firefox 16 will hit the mozilla-release channel on October 9: https://wiki.mozilla.org/RapidRelease/Calendar
How about instead of a new notebook computer? I think that's where this is really going to be a attractive to people.
The origin of the at reply - Digging through Twitter's history
To the best of my knowledge, this hasn't been published.
As jaxn said, Apple has been making this "mistake" with Macs for years and it hasn't hurt them.
Implementing 'if' in Ruby
Wikipedia gives some insight:

Most access is to a national intranet which consists of an in-country e-mail system, a Cuban encyclopedia, and websites that are supportive of the government.[7] Such a network, similar to the Kwangmyong used by North Korea, prevents unwanted information from outside of the country getting into the closed system. One network link connects to the global internet and is used by government officials and tourists, while another connection for use by the general public has restricted content. Myanmar uses and Iran has plans to implement a similar system.[11]

[...]

A new undersea fiber-optic link to Venezuela (ALBA-1) was scheduled for 2011.[12][13] [...] In May 2012 there were reports that the cable was operational, but with use restricted to Cuban and Venezuelan government entities. Internet access by the general public still uses the slower and more expensive satellite links.[17]

http://en.wikipedia.org/wiki/Internet_in_Cuba
Paradoxically, I don't think Mixergy is most useful to the broke failing startup. Failing startups at that stage tend to be time-rich and cash-poor (I know, I've been there!). If that's where you are, I don't think Mixergy Premium is right for you.

As for me, right now I am cash-rich (well, relatively) and time-poor. I barely find the time to do any of the important stuff. You know, like figuring out how to get leads out of linkedin and redoing our website to generate more leads. So for me, if I can pay some double-digit amount of dollars and make progress on those important objectives that have a bottom line impact of tens of thousands of dollars, as I said, it's a no-brainer. I know it's an easy argument to make, but if I sell a single client because of one of Mixergy's talks that will be worth £5-10k this year (based on our average claim size) - and that's not counting future years and other leads that may come from that client. And from following the instructions in the LinkedIn masterclass, I have already generated about half a dozen leads. Sure, maybe none of them will convert, but that's half a dozen more leads than I generated through LinkedIn ever.

Sitting through a bunch of videos that teach you about stuff you can't really apply is a waste of your time and your $25/m. Sitting through a video that teaches you, in a concise manner, something you can use right now in your business is priceless.

Anyway, so to summarise, Mixergy is gold dust for the time-poor and cash-rich, but not the time-rich and cash-poor.
Marketing law: Words & phrases to avoid, w/ safer alternatives
The angel investor in Zynga especially
And iPods. The iPod touch 1st generation, 2nd generation, 3rd generation, 4th generation were just the "new iPod touch".
There is Evolution that is worth taking a look at. But it was buggy and had problems with large mailboxes last time I used it (2 years ago?).
I could write you a small novel, but the short version is, by analogy, the knapsack problem. I can fit so many tasks into my bag for [time unit]. Which ones do I pick to meet my goals? On what basis?

This problem can be cloaked in many different ways: What feature do I implement right now? Should I go to the Python meetup tomorrow? When should I read the sci-fi book that guy recommended? Do I push for the refactor that the code base really needs or the refactor that the client can afford? Should I be answering the phone more or answering it less? Should I cancel my Mixergy subscription? If I can time-afford to attend N events, what is the right mix between developer and non-developer events?

I make a hundred micro-decisions a day that lead to me not shipping. For each decision or decision category, I can give you some reason that makes some amount of internal sense in its immediate context. But ultimately I think I am incapable of really rationally understanding how tens of thousands of tiny choices affect my trajectory over the course of a year at decision-time.

The second generation of the problem is that other people have the problem, and it has a trickle-down effect. Jim irrationally wants to put out a short-term fire vs the long-term solution to the problem. He may do this over my protest. How interested am I in shipping the project, and how interested am I in not butting heads with Jim? It is extremely hard to get the mix right between acquiescing and putting out the fires, educating Jim, and cutting him loose, and that is literally the difference between accomplishing nothing and shipping dozens of products a year.

It's really a problem with rationality in decision-making.
I'm guessing they're working with file formats that can't be diffed or merged. In which case all the version control is doing is just storing the file. Branching, forking or collaboration isn't possible in the way it is with text code.

In that case it really doesn't benefit them at all and is a chore. You'll only get them to use version control if it's hard mandate (good luck) or figure out a way to make it completely transparent to them (something like Time Machine).
I don't want multiple devices

Do you want a 2 pound tablet though? That's the big problem with the Surface Pro. The original iPad at 1.5 pounds was generally considered to be too heavy by a lot of people. I can't imagine adding an additional half pound to it and being able to actually use it as a tablet anymore.
Does WebKit implement unprefixed property names alongside -webkit- prefixed names?
Disclosure (from OP): This is self-submitted; it's something I wrote up last week, and thought it might be useful to HNers.
ACLU-NJ Releases “Police Tape” Android Application
In the keynote Apple referred to it as "iPad", as a proper noun.
I agree, there is a middle ground and it is worth looking at that.

Worked a lot with Java, but also dynamic languages (lots of Python, but also Smalltalk and Ruby). My experience was similar: I was missing something on either side.

Currently I like Scala a lot, and it has a console as well as great collections.
yes, but it's not blhack's use case, from what I read he wants unlimited privates for his own work and the free plan meets his needs.
I also do not have a commute, so I do not have the "how do I make use of this dead time?" question that swombat seems to have. That may play a role in my analysis.

Definitely. As much as I find them useful, I probably would not listen to the Mixergy podcast if I had no dead time - and in fact, that's exactly what I did(n't do), when I didn't have a commute.

But now that I've discovered Mixergy Premium, that is something worth making time for, imho - if, as I've said elsewhere, you can easily afford $25/m but aren't finding the time to learn various practical business skills like the ones taught by those videos.
hmmm, food for thought!
I have so many issues with this post I barely even want to respond. The movement is dumb, plain and simple. The idea that anyone is going to boycott apple because some android users on google plus started a "movement" is ridiculous. The only people taking up the cry of #BoycottApple are people that are android users who wouldn't buy something from Apple in the first place.

Every sentence of this article is inflammatory. Claiming that Apple thinks that they won't be able to innovate is laughable . Apple slow plays features, they do it they way that they want to.

If you're going to talk about the number of things that Apple stole from Android you should probably mention the other side of this two way street.

I suggest that the author step outside the echo chamber that is the tech media and ask anyone if they know who Apple is suing or who is suing them. Ask them if they care that Apple is suing people over stupid patents. Ask them what their next phone is going to be.
I understand what it tries to do. I just don't consider it worthwhile. Having a menu bar inside the browser chrome along with non-native windows is confusing at best if not outright broken. It tries to emulate a user experience that does not fit the browser and should better be implemented as a native app.
Sort of yes. For many games its not the funding, but the exposure a kickstart campaign gives.
And there's always the chance that a drug to cure that particular mutation doesn't exist. What then? Spend millions on years of research to make the drug?

This is indeed the case for most mutations that we're finding in cancer genomes. (That's the bad news).

The good news is that many cancers do have "druggable" genes that are altered, and even though the cells have many mutations, attacking just the druggable gene is often enough to prolong life and improve outcomes.

The other good news is that even though many different genes can be mutated, there are a much smaller number of pathways that are altered. (those for cell cycle control, apoptosis, etc). By targeting key points in those pathways, one drug may be effective against dozens of different mutations.
Do you download the audio? Even when I'm not actively studying Mixergy I constantly listen to both the interviews and courses while I do exercise. You'd be surprised how much sticks in your mind simply by osmosis.
I just signed up and will give it a spin. I was going to install the Chrome Extension but the prompt says:

Add Kiptt?

It can:

- Access your data on all web sites.

- Access your tabs and browsing activity.

Why would the extension need all that above data if it's just bookmarking the page into Kippt?
Steam Greenlight isn't a promotion platform, it's a tool for community-driven curation. It would be kind of hard to use Greenlight to vote when it's not live yet, and there would be no point in voting on Greenlight after it's live. :-)
The most advanced open source IMAP based webmail was RoundCube last time I checked. Not really gmail, but works well enough at least for small to normal sized mailboxes.

http://www.roundcube.net/