skysight-inc/HackerNews huggingface dataset:
> Wouldn't taking GLP-1 (for potential non-weight-loss benefits) be potentially harmful as it may reduce eating even further and lead to being significantly underweight?

Almost certainly at the weight loss dosages people are taking now, but semaglutide (at least) can be tuned up and down for effect. Time will tell what kind of dosage is required for these non-weight-loss benefits.

That said, I think it's more important to focus on how this drug works -- it works in the brain and in specific areas of the brain that we now know are important for weight loss/addiction/inflammation(?) (because of these emergent miracle drug effect). It doesn't seem outside the realm of possibility that drug companies will be able to target these systems with more finesse in the future as opposed to superdosing engineered stable GLP-1 molecules that flood the system.

It is the future understanding of what this drug does that is the real promise for all people -- we are just in the early stages of understanding what we've found.
Does this mean you need to be a paying user for Claude and Gemini or just with GitHub copilot?
The issue with lisp is that linked lists kind of suck on modern hardware.
"Management"
Rise and Fall of Pandemic Excess Wealth
Good. Forcing medical procedures onto people is a violation of basic human rights. And no, I don’t buy the argument that they “weren’t forced to because they can quit”.
I feel like AWS deliberately adds complexity so that people are in way too deep before they realize it, and then when someone finally says, "Could we not just do this cheaper on our own hardware?", it is too complex to make that an easy switch.

Don't get me wrong, I think AWS is a great collection of products... if you either know you'll be small enough to stay cheap, or you have no idea what scale you will need in the next few months/quarters. But if you do have a solid baseline of computing needs, I simply don't recommend them anymore. They are your overflow solution, not your foundational ecosystem.
Obesity rates aren't consistent because access to cheap calories is not consistent across the globe. I don't mean to be glib, there are certainly other factors, but as a first order approximation obesity rates of a region or country are going to be proportional to how easy calories are to access, followed by how satiating those calories are
A classic case of perfect being the enemy of the good. The answers are Gitlab and jj, cheers.
Yes I was talking about aleph_minus_one's post, apologies for the confusion (I got a bit mixed up). Unfortunately it's too late to edit it.

In terms of the social dynamic I agree with you, the "white lies" serve as a way to be considerate of the other person. And it's not just "lies" about them either, if someone is in a hurry or in some casual context and asks how I am and I've had a shitty day, I might say "I'm fine" to avoid them feeling the need to talk through my problems with me. If someone asks at dinner and I spent the morning having explosive diarrhea, I don't share that either. That is a classic white lie but to see that as a betrayal strikes me as extremely bizarre.
GitHub sublates AI deals with Google, Anthropic
My memory of her is Close Encounters of the Third Kind
Not in the open source space.

Rohde & Schwarz might have a solution in their CMW product line. Expect to pay a couple million dollars.
The company didn’t die because they didn’t raise money. They died because they weren’t making money. The SV idea of a company needs to raise money in order to survive is a bit strange to me. If you’re building software, people should pay to use it. If they don’t, then fundraising is irrelevant. In other words, raising money should be for scaling and growth, not figuring shit out.
I have fairly bad eyesight with both myopia and astigmatism (-5 sph, -2 cyl) and I wear glasses. I got glasses with 1.71 index lenses, which I greatly prefer over the more common 1.74 index lenses due to the higher Abbe number, resulting in less chromatic aberration.

Anyway, I use browsers at 150% scaling usually, although the text is finer on my terminals. I don't use any scaling for UI elements and terminals. Using the i3 tiling window manager, I put more commonly used terminals on the bottom half of the screen since I find that the top half does require more neck craning.

I'm 184 cm tall.
App doesn't have to be in focus. It receives pointer events over its own surfaces (plus in some additional cases like drags and grabs). It doesn't receive any information about pointer position otherwise, nor its global coordinates (at least not without extra protocols).
If the covid vaccines were sterilizing vaccines that would be a good point, but they're not. As an example let me cite the case of Anthony Fauci, who kept up to date on his boosters but got covid three times.

(And what do you know, each time he didn't take the Remdesivir he limited everyone else to taking the first year of the epidemic, he took Paxlovid instead.)
If it's so powerful, why is Bezos also apparently now pushing for a lot of changes in the actual writing and ordered conservative writers added to the op-ed board? https://www.nytimes.com/2024/10/25/business/media/washington... and started defending it publicly: https://www.washingtonpost.com/opinions/2024/10/28/jeff-bezo...
M4-based mac mini's (256GB storage) have Thunderbolt 4.

If you need/require Thunderbolt 5, you'll have to step up from $599 to $1399+ for the M4 Pro-based mac mini's.
No, but same thing with different numbers.

Like I asked, where's our cutoff? If obesity on average kills you a couple of decades earlier than otherwise, does treatment for that meet your approval?
"Too Like the Lightning" by Ada Palmer. (First of four books called the "Terra Ignota" series.)

It's one of the handful of books that genuinely changed my mind about serious questions -- in my case, relating to gender, politics, & religion. But it's definitely not coming from anywhere you'd expect.

I compare it loosely to Ursula K. LeGuin's "The Dispossessed". The author paints a picture of a utopia, and gradually we see deep human flaws tear it apart. It starts off with investigation of a puzzling criminal tresspass, which slowly spirals upward into greater and greater consequences -- and it intensely rewards careful reading, or a second reading, as major reveals are subtly foreshadowed early and often.
It's difficult to explain without spoilers... one of the characters feels significantly more fleshed out and real because of some artistic choices in the voice acting.

I am not sure I'd go as far as GP and say that the book is not good, but this is one of the cases where the audiobook feels more like a "production" and not just a book in a different medium.
Totally agree that heavy commenting is the best convention for helping the assistant help you best. I try to comment in a way that makes a file or function into a "story" or kind of a single narrative.
RSS Lets Me Read the Web
The Open Source AI Definition Is Out
This is like saying that driving doesn't work because people still walk and the real problem is transportation. It simply doesn't matter. It's not an argument.
My bet is on the HFCS in the processed food.
The oldest city that we’ve found to date was buried - intentionally - under a mound of earth.

There could be dozens of these sites

Lidar the planet
Five or ten new proofs of the Pythagorean Theorem
The Unreality Is Unraveling
>or just make it harder to find what we’re looking for

Sadly, given their prior removal of dislike counts I expect it's this.
Eliminate the whole op-ed page then, right?
It has been a while since a _useful_ new app came along!
Thank you, i appreciate it to the point I'd be willing to pay for it.

Feedback: Teach people to never ever scan a QR code if they don't know for a fact who created it.
For if you don't, you'll be part of the crowd who is conditioning people to scan all the QR codes they can find without thinking...
I'd give a lot to go back to my 20 year old eyes that could see pixels without special glasses. Sure I can't see pixels (well maybe I still could on an janky third party CGA monitor from 1983), but it isn't worth it. (I'd say save your eyesight, but realistically I'm not aware of anything you can do to keep it past about 45)
Sabine Baring-Gould's Book of Were-Wolves (1865)
What you eat is a very different concept to the amount you eat. Especially on topics like these, the distinction is critical.
Essentially, you pay for database queries and events, with 60'000 included for free, which is plenty for experimenting and small projects. Price per million queries/events is then based on the plan you're subscribed to, and with Starter you have zero monthly fixed costs and only pay for queries and events above 60'000.
No CPU-time and similar that's usually hard to grok.

Take a look at the Accelerate and Pulse pricing details. Prisma Postgres comes bundled with these, so the pay-as-you-go pricing is the same: https://www.prisma.io/pricing#accelerate

We'll continue to make improvements to the pricing on the way to General Availability to make it both as easy to understand and affordable as possible.
QUIC and HTTP/3 (2023)
Also energy efficiency significantly improved, no?
The American Privacy Rights Act's Hidden AI Ban
Frankly, the answer to this seems mundane to me. I served in the Army and put up with hardship and abuse on a level no engineer would ever consider acceptable, and so did everyone else in my organization. Why? Because we deeply believed that what we were doing was worth it for the larger good of country, something bigger than us. It's the same reason athletes in sports that pay shit or nothing at all will do it, or parents will sacrifice, suffer incredible hardship, and sometimes die for their children.

When I moved to my current house, my neighbor had been an engineer for Tesla, but he burned out and decided to renovate his current house, which had an unused barn, into a destination bnb. I talked to him a lot about his experience and why he did it in the first place. He and other Tesla engineers were true believers. They were leading a green revolution that was going to save the world. SpaceX is in a similar situation. Achieving viable large-scale space travel is a literal moonshot that nerds dream about.

It's no mystery either why his antics have failed at Twitter. Nobody at Twitter believes that 140-character microblogging will save the world. They don't get to go to work feeling like firefighters or astronauts. They'll work for pay and comfort, not for mission.
'problem' is a loaded word. The data is coming in saying that this class of drugs provides potentially massive benefits. If I get a lot of benefit but didn't fully address the root 'problem', I still get a lot of benefit.
To be fair, we don’t need infinite years/generations to select for favorable traits.

Such a selection process might already be underway - obesity lowers fertility, so there is pressure towards not being obese. IMO the next generation will already be either slightly reducing their intake, or increase their expenditure of calories. There‘s many ways to do that - becoming taller, more restless, less hungry, decreasing intestinal uptake, reduced enjoyment of food (loss of taste/smell) etc
If it doesn't work, oh well, you'll get VC money for something else.

If it works, the lawyers will figure it out.
Fasting increases growth hormone release (dramatically, in the case of extended fasting), which counters muscle loss. Does this happen with GLP-1?
> Deniers will continue pretending that LLMs are just an NFT-level fad or bubble or whatever. The AI revolution will continue to pass them by. More's the pity.

You should re-read that very slowly and carefully and really think about it. Calling anyone that's skeptical a 'denier' is a red flag.

We have been through these AI cycles before. In every case, the tools were impressive for their time. Their limitations were always brushed aside and we would get a hype cycle. There was nothing wrong with the technology, but humans always like to try to extrapolate their capabilities and we usually get that wrong. When hype caught up to reality, investments dried up and nobody wanted to touch "AI" for a while.

Rinse, repeat.

LLMs are again impressive, for our time. When the dust settles, we'll get some useful tools but I'm pretty sure we will experience another – severe – AI winter.

If we had some optimistic but also realistic discussions on their limitations, I'd be less skeptical. As it is, we are talking about 'revolution', and developers being out of jobs, and superintelligence and whatnot. That's not the level the technology is at today and it is not clear we are going to do anything else other than get stuck in a local maxima.
Patent protection for the early versions has already ended. Teva is making generic versions of liraglutide and it's been available in the US for a few months. The other GLP-1 agonists will be protected for a few more years though.
> It's still "fast enough" for even 120b models in practice

Is it? This is very subjective. The Mac Studio would not be "fast enough" for me on even a 70b model, not necessarily because its output is slow, but because the prompt evaluation speed is quite bad. See [0] for example numbers; on Llama 3 70B at Q4_K_M quantization, it takes an M2 Ultra with 192GB about 8.5 seconds just to evaluate a 1024-token prompt. A machine with 6 3090s (which would likely come in cheaper than the Mac Studio) is over 6 times faster at prompt parsing.

A 120b model is likely going to be something like 1.5-2x slower at prompt evaluation, rendering it pretty much unusable (again, for me).

[0] https://github.com/XiongjieDai/GPU-Benchmarks-on-LLM-Inferen...
This kind of thing is why I think Sam is often misjudged. You can’t fuck around in such a competitive market. If you go in all kumbaya you’ll get crushed by market forces. It’s rare for company/founder ideals to survive the market indefinitely. I think he’s iterated fast and the job is still very hard.
> I’m not sure I understand the point of managing a GitHub organization in Terraform

+1 here

The pendulum went from "no tools, we manage everything manually" to "even smoke pauses need to be tracked and versioned".
Well by that standard is not worth protecting your privacy at all, after all the probability of any of your data being used against you is extremely low. And it's a difficult point to argue, because obviously it's true - but still, why take the risk?

>>Why are you only focusing on one of the bullet points when the point is that probabilities are multiplicative?

Because I'm saying that all of your points don't need to be true for something bad to happen to you. The probability of all your points happening is probably so close to zero it might as well be zero. But if you've given the state any information it can be used against you - like the point made in the video shows. So I think what I'm saying is that yes, your points are improbable, but not all of them have to happen for you to get screwed over.
> in a modern environment that is hostile to it.

Our ancient environment was hostile as well.

> It patches malfunctioning reward centers

It has an impact on them. It does not "patch" them. This is not a rational way to describe any drug.

> it reduces overall inflammation

It can inhibit certain inflammatory pathways.

> it provide cardiovascular protective properties.

It reduces the number of cardiovascular events. Whether that number is normal to begin with is not considered here.

> We need more information and research.

You certainly do.
Use a journaling app, and write a few notes on what you did everyday.
Each week, write a summary, grouped by topic: on project A, did 3 MRs, assisted pre-sales team on product X...
At the end of the quarter, review the weekly summaries. Done.

I've been doing a version of this for the past 14+ years. Every manager I've had always told me I have the most detailed yearly review. It's been invaluable to me, as my work has usually been very fragmented on different topics / activities.
Apple puts the charging port on the bottom because they want to make the upper surface as smooth as possible.

They certainly wouldn't tolerate anything as bulky as a battery door on the upper surface. And designing a battery door for the bottom, which also wouldn't interfere with the smooth motion of the mouse... it's probably something Apple engineers could pull off, but it would take a lot of work.

Combined with the other advantages -- less waste, the fact that charge ports are ubiquitous, fewer moving parts -- it's no surprise that Apple, at least, would prefer a built-in battery.

As for everybody else, I dunno. It may literally just not have occurred to them that some people would prefer it.
https://www.ebay.ca/b/2017-Apple-MacBook-Pro-15-4-Inch-Lapto...
How is that related to medical students taking body parts out of a lab and dissecting them at home?
Show HN: Let's Play (Voice AI) Ball – A Baseball Strategy Game
My 8 year old son is obsessed with baseball. It’s unfortunate because 1) I deeply love lacrosse (I was the leading scorer my sophomore year for UC Davis! Never miss an opportunity to say it!), 2) I don’t know much about baseball, and 3) he’s a diehard Yankees fan.

Although I can’t do anything about his team affiliation or the current 3-0 Yankees deficit in the 2024 World Series, I can do something about teaching him baseball strategy -- despite knowing little about baseball myself. I built this Voice AI game for him to learn more about baseball strategy. In the game, the Voice AI describes a baseball scenario, and the caller has to describe what the defensive player should do. To try it out, call (530) 203-8359.

While my son is obsessed with baseball, I’m equally obsessed with Voice AI. Voice AI is eating the world. We’re seeing Voice AI consume pre-existing call volume (e.g., lead qualification calls, customer surveys, medical appointment setting) and creating a deluge of new call volume enabled by the Voice AI medium (e.g., role playing for professional development (https://solidroad.com/), an AI that introduces you to people with similar interests (https://www.boardy.ai/), and, yes, voice-first baseball games to make you feel like a better dad).

If you’re building in Voice AI and are as enthralled with Voice AI as me, check out what we’re building (https://voice.canonical.chat) when we’re not building fun voice-enabled AI applications. We love meeting other people in Voice AI and helping them improve their Voice AI agents!

Tom
https://x.com/tom_shapland
The expert network industry does this pretty widely but it’s literally never been that much money.

People like GLG or Dynata might contact you for a call or to fill out a survey for 10,50,100 dollars. Those are usually legit. If you are a surgeon or something rare you could command something like 200-500. But basically it has never happened that the fee is more than that. And if it was legit, you would be on the phone with their project manager and being vetted. Likely you are a CEO or C-suite expert so that amount is close to what an hour of your time costs anyway.

If you’re getting offers north of those figures and not directly talking to someone arranging the call then its a pure scam. And think why would someone pay you that amount, if you’re worth that much you probably already know…
You're free to your opinion (legit, no snark intended), the market will deliver to the demand. The cost benefit ratio is obvious, even accounting for potential side effects at scale.

https://www.axios.com/2024/01/18/ozempic-wegovy-weight-loss-...

https://www.axios.com/2024/01/19/weight-loss-drugs-america-o...

https://recursiveadaptation.com/p/the-growing-scientific-cas...

https://www.jpmorgan.com/insights/global-research/current-ev...

Edit: I simply do not understand the hostility towards this simple intervention, my apologies.
Strava is a fitness app. So, apprently, the security detachment of political figures tends to use the app, presumably because they're into fitness and keep in shape, and their location can be tracked through the app.

As the security detachment tend to travel with the people they protect, political leaders locations can be inferred.

The article talks about body guards not being allowed to use social media/apps while on the job, they allow for provisions on use when not on active duty. So, I guess, the guards get a day off, use the app, wherever they are, broadcasting their location.

Crazy stuff.
Cell phone tracking is better at surveillance than the best stuff the military has.

https://www.washingtonpost.com/national-security/2024/02/22/... has a fun story about a time at Fort Irwin (US Army laser tag in the desert) one side couldn't figure out how an attack helicopter got through their defenses, until they did some queries on a commercial cell phone tracking database and found the cellphone moving across the desert at 120mph. Hole identified, plugged for the next round.

And also talks about how the Ukrainians and Russians are having a great deal of trouble with cell phone OPSEC even after years of shooting war.
This Github purchase was incredible
AI Tutoring Outperforms Active Learning
I think the fact that you can find 50% of the people that think he screwed it up, and 50% of people that think he did the right thing. That pretty much should tell you all you need to know.
Samsung solves this in the TV itself. It can be annoying when the edges of the screen are ever so slightly off, but i'm glad I don't have to worry about it. QCQ90S. I wouldn't recommend it since the tv's gui is glacially slow, but then again all the ones I tried last year were.
I know your article is on 8K TVs, but it's worth pointing out that the Dell UP3218K is a 32" 8K monitor (but is also not without its own challenges).
Primes of the Form P²+nq²
As long as the supply chain correctly functions for the entire time you plan on being on the drug.
yeah. I think they have did some refactoring in OS though, to make it more modular. Not sure what are their long term plans for Windows. They probably would have benefitted from some handheld UI for sure.
No need for a black market, there's plenty of public ones (Backmarket, eBay, etc.). That being said $200 seems not terrible given the step change in performance since then (I own a 2019 MBP and think we were very unlucky with our purchase timing). Backmarket seems to sell yours for ~$350-500, so maybe you'll get a little bit more trade-in for it.

I owned a 2014 MBP (~$1200?) for a long time and as late as 2019 it was resellable for $500.
Heh, I do something similar as well, with a 48" LG 4k OLED, which seems popular with other users as well. I got this over another 4k or 8k TV because 1) OLED simply looks better and 2) 120 hz is nice for gaming, but I do want to get the same type of TV but with 240 hz instead for some of the higher twitch games.

I use Windows and the PowerToys utility which might arguably be the best window manager I've used, even about tiling window managers on Linux, simply because I can specify exactly the layouts I want for every single virtual desktop and every single app.

Overall it works well but for the first little while I did get a headache from sitting too close, but it went away soon after.
I noticed that every time I get into a new hobby, Americans online are very much either focused on turning this into something profitable or feel guilty for spending time and money without turning their hobby into a side hustle.

That’s not really how I’ve ever thought about my hobbies. They are specifically there for me to enjoy my time after work.
I dunno... the first time I read that, I interpreted it as "yes our hardware is weak but please ignore that", and reading it again it still rather feels like that. Yes, GNU/Linux has better/lighter software that can get more life out of weaker hardware, but... well, I wouldn't run firefox on 3GB of RAM on my Linux laptop if I could help it; I see no reason to suddenly treat it as reasonable just because the form factor is different.
It's going to get as common as

> New exoplanet discovered

Very soon.

And therefore unworthy of barely being mentioned.