skysight-inc/HackerNews huggingface dataset:
> This is not a call to attack on the FDA

At this point, I honestly think that we'd be much better off without an FDA at all.

It costs >$2B to develop a drug. Most of this is on account of efficacy testing -- phases 2 and 3 of the drug development process -- which are nearly impossible to run. And when drugs exhibit poor or nil efficacy, the FDA sometimes approves them anyway, making the entire process unprincipled. See, e.g., flibanserin, aduhelm, and others.

The result is total regulatory capture. If you're a small firm -- a biotech startup -- you quite literally can't introduce a new drug to the market. Your only hope is to push it through preclinical trials and then partner with -- or get bought out by -- a large "prime" like Pfizer which specializes in regulatory compliance and has the deep pockets required.

Back in the 1940s and 1950s, there were lots of small firms that competed in drug development. Syntex, for instance. That was a period the industry still calls "The Golden Age of Drug Development," and it would be utterly impossible to recreate today.

All of this is without even going into the bureaucratic hurdles which delay new treatments from reaching patients, the chilling effect that the red tape has on pharmaceutical R&D, the way they gatekeep generics, and I could go on all day. It's not just a bad system, it might be among the worst systems possible, as it concentrates all power and all wealth in the hands of a few -- and the patients are the ones who suffer for it.
The netlist simulation of visual6502.org [1] works like this, it basically runs the simulation in a loop until the node network reaches a steady state, which means the current clock cycle is 'done'. This is a C port of that inner loop [2].

[1] http://visual6502.org/JSSim/index.html

[2] https://github.com/mist64/perfect6502/blob/268d16647c6b9cb0c...
it's a misnomer but airspeed is life. we're not talking about people stalling during air combat or aerobatics, we're talking about doing it in the pattern. simply keeping your speed up and knowing the speed you will stall at based on bank angle should be enough.
C already had auto, for automatic storage class specification. It's the default anyway, so I've never seen it used in the wild.
> By that logic, any product/organization that generates revenue mainly through ads would be an ad company.

What logic? The person you’re replying to didn’t explain their reasoning, so any logic you’re seeing is being constructed in your own head and projected onto someone else. In other words, you’re likely responding to an argument you’ve seen (and disagreed with) before instead of what that poster had in mind (which may or may not jive with what is in your head).

Google doesn’t just show ads, they track you and have the infrastructure to sell your information to people who buy ad space. That is fundamentally different from a website that makes money by showing ads, many of which they don’t pick themselves. So yes, Google is an ad company. And they’re one “first” because that’s where their efforts are, not because of the revenue. YouTube, Chrome, their web proposals, it all serves the same goal: ads, ads, ads, and keeping Google’s dominance in the space.
All of this back-and-forth in the AI scene is the preparation before the storm. Like the opening scene of a chess game, before any pieces are exchanged. Like the Braveheart "Hold!" scene.

The rubber will meet the road when the first free and open AI website gets real traction. And monetizes it with ads next to the answers.

Google search is the best business model ever. Everybody wants to become the Google of the AI era. The "AI answer" industry might become 10 times bigger than the search industry.

Google ran for 2 years without any monetization. Let's see how long the incumbents will "Hold" this time.
Watchexec: Execute commands in response to file modifications
If you do a lot of category theory, you most likely have a high "mathematical maturity" (Terry Tao spoke about this)
Even if the math is fairly basic, you need to understand what is important where, which function could be replaced, etc.
With mathematical maturity you realize how some details are not really significant while they take a lot mental space when you don't have it. It's part of the progression.
If LSP can tell you the type, wouldn't it be a nice solution to just have it write it in for you?
I so much more appreciate this style of version numbering compared to being eternally 0.something.
Can your programming language do this? (2006)
A personal audit of restic cryptography (2017)
Nobody advocated against cars, just in favor of more traina. Trains would benefit especially the lower income brackets population with cheap, fast, secure and stress-free transportation.
Consider the case of a YouTuber who gets most of their revenue through superchats. They regularly upload videos, a couple times a week, and receive ad revenue and the od sponsorship deal. Once a week they do a livestream Q&A which is where the bulk of that superchat revenue comes from.

Are they a livestreaming "first" business-man/company/sole trader?

Revenue sources are not necessarily the be all and end all of determining what your key business concern is, or what your business should put first.
As a pilot and tech professional, I completely resonate with your observations. However, the fly-by-wire concept concerns me a bit. I imagine it significantly complicates the onboard technology and makes maintenance more complex and costly. Additionally, I assume the training will need to address potential malfunctions, such as alternate law and direct law scenarios, which might make the rating process more complicated rather than less. How do you plan to tackle these challenges?
> Mozilla [Corporation] would die.

And Firefox would be better off for it.
Hi,

We have created a maths puzzle game were you have to guess the next number in the sequence. It has 4 difficulty level and each level contains 10 sequences. Try it out and we would love to hear your feedback.

Download Guess Next game: https://play.google.com/store/apps/details?id=in.zippybits.g...
> I paid attention to things I liked to do, and found ways to do more of that

This is great advice to people who dont need to have a job that takes up all their time.
Yes, the manufacturing may be in FI, but the shares, the shares are in LU: https://berettaholding.com/en/interview-with-nzz-the-oldest-...

That video must've been shot around this time of year? Google Maps shows Greenhills as being distinctly brown[0], and while we hit the low 30s here recently (the combines have been out in force on the wheat fields) I suppose you all have a good six months yet before your season.

1'100m is a long shot. Locals tend to stick to almost 1/4 that[1], eg https://gr2026.ch/wp-content/uploads/2023/11/ESF-5.jpg

If the Dubrovniks ever remaster Audio Sonic Love Affair, SAKO has a cover illo for them: https://media.sako.global/image/upload/f_auto/q_auto/ar_1.80...

[0] a landscape of "olive and gold" if we wish to wax poetic?

[1] the iron sights on my wife's ca.1900 service rifle can in principle be adjusted out well past 1 km but I strongly suspect that was only meant for volley fire?
>ParkedDomain

https://web.archive.org/web/20180615000000*/ip.network

The domain had a former life (pre-2024) where it bounced to a domain broker sales page, which may well be the trigger.

Aside: I worked at Sophos from '98 to '06, some of the best & worst years of my life.
"How do you explain our product to other devs?"
I should name a server bureaucracy because it's the one word I haven't learned how to spell yet.
Okay suppose it freezes, so what? It will melt again
or ifconfig.io
Please, by all mean, join the class action lawsuit. They will claim that you agreed to the Terms of Service that said that they could shut down the game at any time for any reason. There is no theft, when what you paid for was access to a service. You can't just demand that companies only sell you what you want, or even give it to you retroactively.

What you can do, is to demand transparent, non-deceptive, and fair terms of service. What you can also do, it to speak with your wallet and refuse to play online-only games. It's not a human right to play games, you know.
The lost Amiga art is never shown, in this article or any of the linked sources. The 9 images on that "lost" disk aren't actually displayed. The disk itself is the valuable object, kind of like Picasso signing a napkin. But, even the disk isn't shown. None of these articles say whether anybody tried reading the disk.
Because you chose to do unpaid QA work for a free, publicly accessible utility. Thank you :)
> The rubber will meet the road when the first free and open AI website gets real traction. And monetizes it with ads next to the answers.

The magic of genAI is they don't need to put ads next to the answers where they can easily be ignored or adblocked, they can put the ads inside the answers instead. The future, like it or not, is advertisers bidding to bias AI models towards mentioning their products.
In a similar vein, I use `dig` with Cloudflare to find IP addresses:

dig @1.1.1.1 ch txt whoami.cloudflare -4 +short | sed "s/\"//g"

dig @2606:4700:4700::1111 ch txt whoami.cloudflare -6 +short | sed "s/\"//g"
I wish I didnt read this because this sounds crazily prescient.
> That is completely untrue and the usual disingenuous "let’s never talk about capture and geo engineering less it distracts from our goal of reforming the world from morally impure practice" served by the traditional aler-mondialists/ecologists.

Respectfully. Bollocks.

It is absolutely demonstrably true that the article linked here sidesteps how sulfur emmissions are a band aid solution requiring constant topping up that fail to address underlying issues.

It is absolutely demonstrably true that the largest CO2 sequestration project on the planet hasn't yet met it's own goals and when and if it does the amounts stashed below will be tiny in comparison to the amount released.

> traditional aler-mondialists/ecologists.

Yeah, you might want to work on that, I'm retired from a career in global exploration geophysics for transnational energy and mineral resource concerns .. that's a full antipodean faceplant of an over reach there.

> I am assuming

You're incorrect.

> you count the full estimation of emission during construction

Nope.
> if you are trying to have an extremely talented programmer paired to you

I've found it to be on par with Stack Overflow / Google Search.

More convenient than cut/paste but more prone to inaccuracies and out of context answers.

But at no point did it remotely feel like a top tier programmer.
You don't need NordVPN (if you have SSH)
Don think you need to destroy all of capitalism. Just abolishing copyright on music would be a surgical strike with pretty good effect I believe.
Agreed. They'd have a much better chance focusing on specific deceptive business practices. The EU would be more likely to require explicit and clear labeling of what it is that you are buying.
I don't see a point in imagining an impossible hypothetical. If we imagine a world with infinite resources a lot of problems as we know it would go away. It is precisely because we live in a complicated and imperfect world that we have problems, and we must solve those problems within that reality. Competing priorities between different parties (e.g., "oil companies") cannot be simply ignored if you want to actually discuss anything meaningful and not merely wishful/imaginary.
Others have posted alternatives, but I really like the fact that you can self host it:

https://github.com/leafcloudhq/echoip
When I gave the same prompt to both, Sonnet 3.5 immediately gave me functional code, while GPT-4o sometimes failed after 4-5 attempts, at which point I usually gave up. Sonnet 3.5 is spectacular at debugging its output, while GPT-4o will keep hallucinating and giving me the same buggy code.

A concrete example: I was doing shader programming with Sonnet 3.5 and ran into a visual bug. Sonnet asked me to add four debugging modes, cycle through each one, and describe what I saw for each one. With one more prompt, it resolved the issue. In my experience, GPT-4o has never bothered proposing debug modes and just produced more buggy code.

For non-trivial coding, Sonnet 3.5 was miles above anything else, and I didn't even have to try hard.
Idiomorph: A DOM-Merging Algorithm
Following their answer in another comment, you don't; aircraft turns into a useless brick and you pull the parachute and hope for the best.
Location: Bengaluru, India / Remote in UTC +5.30 / Canada
Remote: Yes, open to in-person
Willing to relocate: Yes (India/Europe/Canada)
Technologies: Python, Java, AWS, Redis, K8s, Docker
Skills: Backend Engineering, Infrastructure, Operations
Résumé/CV: https://nihardwivedi.com/nihar_dwivedi_resume.pdf
Email: dwivedi.nihar [at] gmail [dot] com

SWE interested in all things distributed. I was most recently a Senior SRE at a cybersecurity startup in Dallas, TX. I work at the intersection of Operations, R&D, and SWE so my work involves everything from arm-twisting [major cloud provider] into launching new (previously unavailable) Redis instances overnight to debugging unknown edge cases in production code. Working at a startup I’ve learnt to move fast while NOT breaking things (and quickly fixing things I do end up breaking), and have worn various hats such as Cloud Security Engineer, SWE, Sr SRE etc as the business evolved. I handled customers directly and owned parts of engineering and infrastructure. Experienced in backend engineering, infrastructure debugging and cloud operations. I'm actively looking for my next adventure(mid to senior engineering roles), if this sounds like a good fit please don't hesitate to reach out!
> It is an argument for realizing that the planet is and will always be in climate flux, whether affected by human activity or not, and that our long term strategy needs to be adaptation and cooperation, not to engineer the climate to stay as it was in 1700 and selfishly laying claim to temporarily blessed locations.

The climate flux would take thousands to millions of year to run its course before anthropogenic activity accelerating it by thousand-fold. In that case we could adapt easily since even evolution, as slow as it is, was capable of doing so without technology.

We know that things change, including the climate, the tectonic plates, etc., the issue is how fast things change, that's where catastrophe lies and the call is not to keep the climate as close as possible to the 1700s but to deal with the mess we created and slow down the process of change so not only humans but other species have the chance to adapt as well.
Actual content:

> Calming activities reduced anger in the lab and the field, they found, and across other variables like methods of instruction or participant demographics. Effective arousal-reducing activities included slow-flow yoga, mindfulness, progressive muscle relaxation, diaphragmatic breathing, and taking a timeout.
The sea is fine, the land is fine. The planet is fine as well.

Think of many extinction events this planet had previously. Up to 90% of life died.

However, humanity needs to pay more respect to the habitats of the native species. But for a few dollars people easily looks the other way, unfortunately.
Yes, in a way. When I want to do something that I've never done before (typically as part of a larger project I'm working on), I often ask ChatGPT/Claude for advice and get really useful just-in-time explanations, as part of a conversation that I often continue throughout my work on that task, getting additional support and guidance. I usually learn a lot from these conversations, such that the next time I approach a similar situation, I can generally do so on my own.

I'm not necessarily arguing that there's no more need for any ahead of time "study", but I think that with the equivalent of a personal tutor for everyone, we can achieve a lot more by learning while doing, instead of study being a dedicated activity.

I might be a bit sentimental here, but some of these interactions with an LLM bring back memories of me being a kid working on some small project at home on a Saturday, and being able to come to my dad for advice and even hands-on assistance. And on a less sentimental note, I believe that effective use of an LLM while working on a project fits really well with Papert's Constructionism approach to learning.
Nah, you're just wrong about your quality measure. The production of "conventional pap" is very much a form of mastery. And so is good marketing.

Raw technical skill isn't enough for success, you also need an audience for that skill. It doesn't matter that your skill at the guitar is divine if you only play technical pieces only other expert musicians appreciate.

Take Minecraft for instance. A graphically unimpressive game made by nobodies before it got famous. It didn't get so big because it demonstrated the pinnacle of game development.
So how toxic is Sam Altman?
That’s how Google works. And also why Google doesn’t work anymore.
The website chose to put reCaptcha on there. They don't get to pass the buck to Google.
Where would you land a plane full of tanks in Normandy, if not in the airports they already control? Not a war expert, just logistic curious.
Wasn't the new law literally bought by some really wealthy people?

Don't get me wrong, I can work really hard if I have to. But only for my own benefit and not for a manager who is taking advantage of me, or is really bad at planning.
>This is why it's probably a good idea to work with a HDL instead of just trying to wing it.

During my CE studies I got hooked heavily on FPGAs and HDLs, but the amount of times I actually ran into a timing problem, which only occured on hardware, because of these delays, can be counted on one hand. Playing around with this crap since about 2018. The worst one was where I got clock domain crossing wrong while trying to get DDR3 RAM working for my master thesis. It worked flawless in simulation. Took me weeks to find the wrong status signal

Yes, they can be a serious problem. Yes, you should know about it. But no, it's not necessary
Fix:

ps() { for i in /proc/[0-9]*; do readarray -d '' -t cmdline < "$i/cmdline"; printf "%s: %s\n" "${i#/proc/}" "${cmdline[*]}"; done; }
Async Transparency (2021)
We are using Microsoft Defender SmartScreen here at work and also stumble upon quite some domains that are blocked. iso20022js.com currently on front page for example is also blocked. Along with web.archive.org :(
I have a hard time taking seriously a poll with n=500 and absolutely no other sample observations provided.

Are all respondents from US? Are they using it at work or at home for pet projects? What's the median size of the company they work at?
I'd replace "extremely talented programmer" with "knowledgeable junior", in my experience. It's much better than GPT-4o, but still not great.
is the whole thing true or not?
Without a trust chain measured boot is security wise meaningless and doesn't work.

But you don't need any fancy PKI or vendor certificates for a trust chain, local trust is good enough.

I.e. the problem of secure boot isn't that it has a secured boot chain but how it has one.

Either way measured boot is still a nice think to complement a secure boot chain.
> The fact is, even if we reach net zero in 2050 - which is unlikely - the amount of GHC in the atmosphere will be quite high and the capacity of the ocean to absorb some which we are relying upon is far from infinite and might be slowing down. We need capture. We won’t fix the issue without. And to do that we need time which geoengineering could give us.

The amount of energy required to recapture the emitted CO2 is mind-boggling though. Reducing it in terms of thermodynamics give a better overlook on how absurd the amount of energy would be required to revert CO2 into some other stable form that can be buried somewhere, as much as I'd love some magical technology enabling that we simply do not have the tech, we do not have the abundance of energy to capture even 1% of the CO2 emitted in a year.

If we went full sci-fi with dependable fusion reactors providing as clean and cheap energy as possible we would still need many, many reactors tasked with just providing energy to capture CO2.
std::deque, a container with some quite useful theoretical properties, is completely unusable because the node size is not specifiable by the user and MSVC chose 16 bytes (I think, insanely small nonetheless).
Reference - a great read - https://en.wikipedia.org/wiki/The_Soul_of_a_New_Machine
Things like that exist in neovim:)

but I'm curious if LSP can write it for me why not just have compiler infer it?
Done that many times, or even fasting for days. I dont think it is hard at all. The trick, what most people fail to get, is the right food to intake. And perhaps the hardest part, taking quality nutrients and food during calorie diet is quite expensive compared to simply eating junk.
Advanced Matrix Extensions (AMX) Guide
If the replacement can't figure out how to use an IDE that gives them the answer, they're very likely going to be slow - but auto has nothing to do with it. They're just not an experienced dev.
Not sure whether they are already doing this, but the fiber could simply connect to a relay rather than the operator themselves, that way the operator can still hide far from the connected system and use wireless outside jamming to control if that still makes sense.
WordStar 7, the last ever DOS version, is re-released
I'd say it depends:

- Depends on stage of study
- Depends on type of concept
- Depends on how the student learns the most effectively.

There's only one way I think your statement is true, and that's if you add "solely".
The free Bing CoPilot already sometimes serves ads next to the answers. It depends on the topic. If you ask LeetCode questions, you probably won't get any. If you move to traveling or such, you might.
What are your thoughts on fundraising for creators?
Hi
My name is Elshan, and I'm the CEO of Fliq (https://fliqapp.io/). Fliq allows investors to invest in creators in exchange for a share of their future earnings. We believe creators are a significant part of the market, but they often face challenges when it comes to rapid growth or starting from scratch. We think that if creators had access to investments, they could accelerate their growth.

What do you think about it?
> The "AI answer" industry might become 10 times bigger than the search industry

not a chance
Curious why this is allowed? NDA do not apply?
I think you misunderstood the point. There's a specific thing regarding alignment that Schulman and OpenAI disagree on, and that thing is not revealed to us. There are countless possibilities, but we are left in the dark.

For example, his focus on alignment could be more about preventing the end of human civilization, while Microsoft/OpenAI's focus could be more about not expressing naughty opinions that advertisers dislike.
The ships in the pic are not that tiny. I just looked up "US 310 ship" (the rightmost one) and it was a 100-meter lander that could definitely carry at least a dozen heavy tanks, or ~30 trucks [1]. You would need a lot of planes for that.

[1]: https://en.wikipedia.org/wiki/USS_LST-310
For all of the talk about regulation, there has been a lot of concern about what people might do with AI advisors. I haven't seen a lot of talk about the responsibilities of the advisors to act in the interest of their users.

Laws exist in advisory roles in other industry to enforce acting in the interests of their clients. They should be applied to AI advice.

I'm ok with an AI being mistaken, or refusing to help, but they absolutely should not deliberately advise in a manner that benefits another party to the detriment of the user.
GPT-4 is way more powerful than GPT-4o for programming tasks.