skysight-inc/HackerNews huggingface dataset:
The $1.1 billion figure is for Truvada total, not for PrEP specifically. It’s perhaps notable that Gilead chose not to break that down, given that the original claim they were responding to was about PrEP specifically.
Something like once every ten years
This is going to result in an awesome Applied Science video... I hope!

Making this at home will be quiet interesting.
This guy does some amazing (mostly motorcycle related) stuff:

https://www.youtube.com/@OddsandEndsMachining/videos

Including sand casting a 350cc V4 two stroke engine block (for a motorcycle). He gets a foundry to do the actual metal pours, but this guy: https://www.youtube.com/@OzBSABantams/videos sand casts cylinder heads and triple clamps on his driveway.
From my experience, the same people who love using Scrum are the same ones who post cringy stuff on LinkedIn. You just can’t reason with them. One time, I tried to reason with a middle manager who insisted on using it. He had no previous experience or education in project management, whereas I’m a certified PM. I tried my best to explain that just because a tool worked in some scenarios, it doesn’t mean it will work here. Long story short, it was dismissed, and Scrum was implemented because “all successful big companies are using it!” Less than a year later, three of the best engineers on his team left.
There's certainly no sciernce that demonstrates that human life is viable on the surface of mars.

Outsidfe of atmosperic gases, there is the issue of no vanallen belt, and thus no protection from the solar wind.

Cellular damage has been demonstrated in every astronaut that has ever stayed on teh space station. Mars willbe the same. The surface is unihabitable.

I've been saying for years: anyone who wants to know what it will be like to live on Mars should bury a cargo container in their back yard, and live in it for a year.

Teraforming Nevada would be much more successful. But apparently even that's not on the table, as Earth destroying human behaviour has only accelerated since the Kyoto accords.
It is kind of coming true now, since all current consoles both encrypt and sign savegames to lock them to your account, and most (don't know about xbox) don't even let you copy your saves anywhere but the console and paid cloud storage.
> I can say having recently gone from coding at a desk 8 hours a day to working full-time on a farm with no heavy equipment, your food intake absolutely should increase.

Yeah I think people are missing the transition phase of this equation.
Fairly confusing UI - I thought I had lost my room plan I had made until I saw it in the "Submit for UI" queue. I see some broken images too.
> Learning is a menace to planning

Ooh, that's a cool thought that the more learning needed, the more planning is hard. True, and I haven't put that together before.
AMD is also very limited by its infinity fabric, with one ccd CPUs capping out bandwidth at something around 5600MTs with memory frequency above that mostly just improving latencies
There is no serious person that could think that Google is a privacy focused company. Their entire business is founded on knowing everything about their users. It's an ad company. They need user data to function and they will never release tech that compromises their business. Just look at the direction of ad blocking and chrome to see where they are headed.
Obviously it's not perfect indicator, but if a company lacks standard procedures it is a probable sign of mismanagement or lack of management.

Maybe it is still nice to work there, but it will slowly fall apart.
This sounds like anti-anxiety over correction to me.

We don't know how much future planning anxiety is warranted without knowing the future. We certainly know that past societies have a strong survivor bias for people who worried about the most significant life decisions they had.

A very flexible person and a turnip may both be well tuned to the economy at the moment but a less flexible person should be anxious as much for the behavioral effects of making decisions lightly on making future decisions in different circumstances.
anti-teraforming...
There's no way it would work out economically: compared to Mars, it would be literally cheaper to build every one of these 100 billion people a US style suburban house with all the power, water, and sewage connected. Probably by an order of magnitude or two.
What BIM formats does it support?
I feel a bit paralyzed by Fear Of Missing Io_Uring. There's so much awesome streaming stuff about (RisingWave, Materialize, NATS, DataFusion, Velox, neat upstarts like Iggy, many more), but it all feels built on slower legacy system libraries.

It's not heavily used yet, but Rust has a bunch of fairly high visibility efforts. Situation sort of feels similar with http3, where the problem is figuring out what to pick. https://github.com/tokio-rs/tokio-uring https://github.com/bytedance/monoio https://github.com/DataDog/glommio

Alas libuv (powering Node.js) shipped io_uring but disabled it latter. Seems to have significantly worn out the original author on the topic to boot. https://github.com/libuv/libuv/pull/4421#issuecomment-222586...
Honestly, the only feature of 1Password that is locking me in is their MultipleVault support.

I have a lot of different vaults, every side project has a different vault, every contract I do has a different vault, and I split a lot of my personal stuff up, I have a vault I share with my partner, personal vault, one with finance stuff, one for all my software licenses.

I then have my main search setup to only use my personal vault, my shared vault with my partner, and two other vaults.

I can't do this with Bitwarden. The best I can do is a folder per 'vault' and then remember to select which folder I want every time I auto-fill, which adds enough pain to the workflow that I just won't make the switch.
I agree. I have some floor plans of my apartment and I'd love to try but for $50AUD for both floors, I don't know what I'm going to get - or if it's editable after the fact ie adding furniture - or if I'm stuck with what I get on the first go.
What's the point of not enjoying the fruits of your success now if you cannot leave this Earth with the wealth you accumulated?
Ickx did it in protest though (against FIA's reluctance to increase safety rules in general and against the traditional Le Mans start in particular)

https://en.m.wikipedia.org/wiki/1969_24_Hours_of_Le_Mans
The public gets access to a life-saving drug that otherwise would not exist, which is exactly what the government is paying for. You can reasonably argue they they should get more, but arguing that they should get some ROI is moot; they're already getting a tremendous ROI
Nobody seems to be able to answer the key question whether it's a marker, or a driver.
I am happy to get out of
The video of the small unmanned vehicle carrying twin mininguns(!) for drone defense was rather nifty as well. If it had appeared in a video game, more than a few, myself included, would have declared it implausible but there it is.
Show HN: OllamaAgents – Your Natural Language Gateway to Linux Mastery
OllamaAgents is a TypeScript-based CLI application that provides a Linux command interpreter using the Ollama API. It converts natural language queries into appropriate Linux commands, executing them if requested, offering explanations and cautions when necessary.
> anti-teraforming

It could be argued that the early days of climate change made the most-inhabited parts of the world more livable by making winters less harsh.

That said, I was mostly trying to draw attention to "once it's easy to terraform earth" being nonsense. We have the demonstrated ability to alter the Earth's climate.
I think folks are misreading the article. Its not claiming that AI research isn’t valuable, its advocating for not pivoting into AI research. Research in any field requires a giant surplus of passion and talent. Go to where your passion and talent can bear fruit, not where your spreadsheet of pros and cons and risk adjusted pay grade lead you.
The more I think about a human future in space the more I wonder whether settling space itself is a better idea than trying to settle a planet.

None of them are habitable. All of them have too little gravity for us. So build factories on the Moon, which has only 1/6 gravity, and use those to build huge stations with rotational gravity that we can launch from the Moon (with its low gravity) and live in those. Use ion engines or solar sails to slowly push them around the solar system if we want.

Eventually the Lunar and asteroid-based mining and factories would be mostly robotic. We would live in things that look like the giant stations in The Expanse or O'Neill Cylinders.

Life support on such a station is not substantially harder than it would be on the surface of the Moon or Mars. It could be easier due to the absence of things like nasty abrasive dust, storms, etc.

Over millennia eventually our solar system ends up with something like a living/inhabited Dyson swarm. We become actually spacefaring, not just living on another planet.
I think if this is kind of missing the point. I don't believe these things are fundamentally incompatible but I do believe there is a big element that's missing from this when we talk about reliability. This is simply looking at a bit of code that is doing things that potentially could have unknown outcomes because the way it has to hook in to do its job. Fair enough there is always risks in doing things like that and anyone can make mistakes that have led to catastrophic failures.

The real problem isn't that a mistake was made or a series of mistakes were made that allowed this code to be released. The real problem is that when it was released it apparently functioned more like a virus or a worm infecting and crashing everything along its way. So it appears crowdstrike is nothing but a massive botnet. This is where the problem lies because vast numbers of systems went down and remained down for a long periods of time. So apparently the best practice that people were taught was to not try and isolate the scope of any rollout or deployment of something new. Put it on everywhere all at once and YOLO seems to be the fundamental guiding policy from crowdstrike that was blindly followed by their customers.

Having been in IT long enough anyone knows this is an idiotic practice. This is the kind of mistakes only a junior admin would make. So either we have a junior admins running vast amounts of core IT infrastructure around the globe or we have idiots defining policies without technical guidance and understanding how things really work. Auto updates let's check that box off our policy without thinking how do we do this in a safe way to mitigate issues. Simply staging something like this so it's deployed in line with a company's redundancy model means that you can have a security and reliability. Because you don't need to look at the reliability of an individual system those will always have problems even if it comes down to simple capacitors burning out. It's about reliability of your service as the whole and this is where the failure really was. I blame the IT administrators as much as I do crowdstrike. For allowing these kind of policies to be put in place for allowing this kind of thing to happen. If this was rolled out in a manner consistent with their redundancy strategy they would have seen that they lost some redundant systems and known to halt what's going on.

Before you say but blah blah blah zero day we have to account for that. If crowd strike is your only way to account for a zero day you have lost already. Security is a multi-layered approach such that a zero day shouldn't cause this kind of panic because you have multiple layers protecting you against a zero day. And you can still deploy an update in line with your redundancy model.
Great system, no complaints!!
Side note: This is an interesting headline for dating a person. My instant/initial thought when I read "I turned an old phone into a NAS" was to picture a rotary phone somehow modded with ethernet and hard drives. "Old phone" to me means a rotary phone. After a few seconds I realized "old phone" to many people now could still mean something that's running Android.

That said, this is really cool. I love clever ways to re-purpose older-but-working phones!
Achieving net zero greenhouse gas emissions critical to limit climate tipping
That sounds interesting, but make sure it's only funding one-offs.

We don't want a repeat of lotteries funding schools, where that money becomes expected and then the government doesn't give as much direct funding.
I would hazard to say if that's your threat model, you're better off not using the internet in general. VPN provider won't really matter ultimately, there's a hundred things on either side of that tunnel that you have to take care of.
Biggest data breaches ever leaks details on billions of users
I have received an email that my SSN is compromised, what a problem !
strlcpy() is my favourite, alas the GNU folks stubbornly refuse to embrace it, last I checked.
it's animal agriculture - it's as far from natural, sustainable, or ethical as you can get.
>That will never happen.

Using natural reproduction you're correct. Never say never, though: we could massively boost the birthrate and the population by turning to artificial methods. Aldous Huxley's visionary utopian novel "Brave New World" discussed how this could be done back in 1935. Once we develop the technology to make "artificial wombs", we won't need natural reproduction any more and can create as many new people as we want.
Yes, Lenacapavir is just a chemical.

It's HIV itself that "knows" where the nucleus is and is actively trying to get there once it's inside your cell. It does this by walking itself along your cell's microtubial network. It would be fascinating if it wasn't so deadly.

I'd recommend watching this video: https://vimeo.com/260291607

See timestamps 1:33 and 2:47.
> Gilead claims that is false and that they spent 1.1 billion on developing Truvada. https://www.gilead.com/news-and-press/company-statements/gil...

You are quoting a corporate press release that was written in response to an editorial criticizing Gilead, which was based on my colleagues' work.

This is a great example of how easy it is to fall for propaganda, because not a single thing in your link refutes what I said! They spent money developing Truvada as a treatment for HIV, then made that money back in record profits for nearly a decade. Only then did clinical trials for PrEP begin, and for those, Gilead donated only the production costs of Truvada (which are minimal). They did not spend any money in actually conducting the trials - which, as pharmaceutical companies are generally very quick to point out - is where most of the costs of bringing a drug to market are.

Gilead is claiming that, when it spent half a billion dollars to acquire a biotech company that went bankrupt, 100% of the money in that transaction should as "R&D related to Truvada". This is preposterous. Neither the SEC nor the IRS would endorse that accounting, which is why you're seeing it in a press release and not their 10-K.

That's a ridiculous claim even when you're talking about the development of Truvada, but that's not even the question at hand. The actual topic is how much was paid for the development of PrEP, which came nearly a decade later, and for which Gilead paid nothing but the per-unit costs of production.
https://www.cnet.com/culture/the-joy-of-microsofts-avoid-ghe...
I spell out "trillion / quadrillion / quintillion bytes" for base-10 terabyte, petabyte, exabyte when the distinction is important. they're also unlikely to be confused with long-scale.
Even if it made the surface of Mars more conducive for a while for radiation hardened plants, without a guaranteed magnetic field having the evaporated water (hydrogen) get carried away by the solar wind seems like a bigger issue.
But do the experiments replicate better in LLMs than in actual humans? :D

We should expect LLMs to be pretty good at repeating back to us the stories we tell about ourselves.
Funny, that happened to a neighbor. There was this teeny crack in a pipe, and a tree root had squeezed into it then ballooned into this alien creature that blocked the drain in an attempt to suck out the water.

Life finds a way.
I am an active user of both Selenium and Puppeteer/Pyppeteer. I use them because it's what I learned and they still work great, and explicitly because it's not Microsoft.
No, Americans can't handle wearing a mask without losing their minds. Over here in Japan, people wear masks all the time (normally when they're sick, or have hay fever); it's no big deal.
That would be amazing! More businesses need a costs-plus gun held to their head.
"National Public Data" sounds like the name of a nonprofit with a nationwide presence, like NPR or PBS, but it's just the trade name for "Jerico Pictures," a small Florida company with (judging from Crunchbase) 1-10 employees. Shouldn't there be regulations for names like this, similar to how the National Bank Act controls the use of "National" in names of financial institutions?
chinese remainder theorem implementations fail if there are duplicate factors
What do you do when you are handed a DLL with publicly exposed types? You can't recompile someone else's DLL without the source, but the public non-sealed types are totally open to inherit from; it's just a question of how useful the inheritance would actually be if there's not a logical public interface (as provided by the original designer).

Maybe you can read all the public fields, but you can't actually modify them or create functions that modify the object. You then must wrapper around the instances and fight to bridge every little behavior between their code and yours.

This to me is evidence that one core tenet of OOP "Open to extension" is in-practice meaningless.
Stripe will take pretty much any excuse to terminate an account and pocket the money. At this point it might as well be part of their business model.
So counter opinion. Current lenses just seem to be a way batter optically than in the past. Sony are super expensive lenses but even if you go Sigma, Laowa, Samyang… it is not cool but some of the lenses are just better and you wont pay that much more.

I used to have Canon DSLR woth some of the better lenses for that system. Recently i got Sony and to my surprise there is pretty noticeable difference. Like i have some manual focus LAOWA and it just destroys comparable (much more expensive) canon lens from 15 years ago in terms of image quality and sharpness.
I'm not sure what you mean by the initial graph being just all open, but I'm still convinced that modelling things only in the heuristic is wrong. Here's why it fails eventually,

Hacking only the heuristic side will seem to work as intended on short paths, but as the f-value (g+h) naturally starts being dominated by g as the solutions become longer, you'll see that the hints at what not to do embedded in the heuristic will start to seemingly become neglected by A*
I the words of Humpty in the Humpty Dance...

"Alright, stop what you're doin' 'cause I'm about to ruin."

Seems to me that this is a fast changing space of product offerings vs adaptation of regulations. Some transactions violated, some did not. Some planned future Ripple developments could cross the line. Seems that Ripple just needs to continue working the system, so the regulations catch up and give the entire space some guidance on what they can and can't do.

Overall a positive development. The penalty was reduced from something like 2Bs and XRP jumped 20% on the news.
> more I think about a human future in space the more I wonder whether settling space itself is a better idea than trying to settle a planet

It's explored in A City on Mars [1]. It's technologically more remote than planetary habitation.

Mars gives you some gravity, some pressure, some protection from radiation (less from the atmosphere than from the planet) and asteroids and plenty of ISRUs, from water to CO2 to dry mass. With a space station you have to do all of that yourself.

[1] https://en.wikipedia.org/wiki/A_City_on_Mars
> You have to trust Apple and if you don't then buy another computer.

No, I don't have to trust Apple or anyone absolutely, and I can and do use a Mac, as the least bad option for my purposes, without fully trusting Apple. You're presenting a false dichotomy. Trust is a matter of degree, not all or nothing. In general I trust my mother (except her advice, which I often ignore), but if she insisted that she had to install cameras in my home for my "safety", I would start to have serious doubts about her.

> Because they have the ability at any point to push software to your computer that compromises your privacy and security in almost undetectable ways. And short of them having an entirely open-source OS that will always be the case.

1) They can't push software to my computer, because I've blocked the software update mechanism with Little Snitch and only install when I'm ready.

2) Open source is not a panacea, as demonstrated by the XZ Utils backdoor.

Moreover, closed source does not render users helpless. Closed source software can be reverse engineered; indeed, I've done that myself with macOS many times. The behavior of closed source software can also be observed in various ways with various tools, for example, the aforementioned Little Snitch. And even when macOS bypassed Little Snitch one time a few years ago, that was detected by developers. The whole world is watching Apple closely, so the company can't simply get away with whatever they want undetected.

> The whole point of their privacy stance is to protect you from companies like Google and rogue governments who we already know can't be fully trusted

We already know that Apple can't be fully trusted.

We also know that Apple actually caters to "rogue" governments such as China, by removing apps from the App Store at the Chinese government's request, as well as handing over control of iCloud servers to China, and reportedly Apple source code too, for inspection.
You misunderstand me. They are reading it. They won't tell people they they're reading it without a good reason. They want people to keep sending data.
The post includes some good remediation advice for application developers at the end.

As a user, an already available mitigation step is using uBlock Origin and enabling the prebundled "Block Outsider Intrusion into LAN" list. It's been an option for years and protects against this very vector (including 0.0.0.0).

That should give you an idea of how novel this finding is, BTW.
https://archive.today/EnAMk
I wonder if this could be used for testing marketing or UX actions?
The even greater problem is wider ambivalence, or even hostility, to revelations of wrong-doing of power. Edward Snowden revealed illegal NSA wire-tapping of American citizens, among other egregious violations of the law, and yet he still remains in exile. His standing among both liberals and conservatives remains poor. I do not understand why this is so, but it's not hard to understand how such treatment has a chilling effect on any reporting on abuses of power. It is hard to believe, but it appears as if the general public no longer has an interest in keeping power in check (or asserting their rights, which is the same thing).

It feels as if something critical has changed in the zeitgeist. It felt like it was a point of pride, honor, integrity and courage to share with the wider public information about the abuse of power. It felt like, even if the organization might come after you, ultimately the backstop of reasonable public opinion (and the justice system) would have your back. I no longer believe that is the case, and it is a great loss. We despise our own heroes, now.