skysight-inc/HackerNews huggingface dataset:
Mice are excellent models for human disease due to their genetic similarity, with 98% of human genes having mouse counterparts. Their comparable reproductive and nervous systems, along with susceptibility to similar diseases, make them valuable research subjects.

DNA manipulation in mice, through breeding or gene editing techniques like CRISPR-Cas, allows researchers to study specific genes and diseases. Using mice is faster than conducting initial studies on humans, allowing for rapid testing of hypotheses and treatments before moving to human trials. Mice also have much shorter lifespans and faster reproductive cycles, enabling researchers to study diseases and genetic effects across multiple generations in a fraction of the time required for human studies.

Maybe if OP would like to sacrifice their children and grand children... sounds a bit insane doesn't it?

Here is a nice paper for you to read https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987984/
> but wheels are usually allowed to spin at different speeds to facilitate pavement driving and turning

To drive home why NPS cares about this, the way the car detects how fast the wheel should spin is by detecting slippage. But every time that happens, you're shredding up the road. That turns AWD vehicles into pothole machines.

I drive a Subaru and I drive it off road. I would feel comfortable driving it in most off-road conditions, from a safety perspective, but I won't because I'm fucking up the trail.
> AMD does offer custom x86

Not the same thing. On X86 you have to pay AMD or intel to design something for you.

In arm, you get to decide who design your chip or even have your own in house CPU design team.
As a teen I was quite taken by Fuller. Even back then I was smart enough to wonder why his ideas weren't incorporated in all the things around me (except the geodesic dome climbing structure in the schoolyard), and eventually put 2+2 together and figure that maybe his ideas weren't particularly great in practice. I think i was the "dymaxion car" that got me thinking.

It did help me develop some immunity to the conspiracy theorists who claimed that this or that invention was suppressed by "those forces" that wanted to thwart progress.
I've tried to understand what the heck you're talking about here in relation to the US, but it doesn't scan.

Perhaps you could explain more in detail. I mean, Hispanics aren't pushing out Christianity and pub food... And they like Americans plenty.

Side note: If your economy would otherwise be shrinking because of a shrinking population/labor pool, immigration is good.
There's the 'long tail' aspect to ephemeral stardom and what people get from it. Most musicians I know (and I know a lot from the local music scene) want foremost to perform. Money and fame would be really great, but getting up in front of an audience is what they most want to do.

A lot of 80's and 90's bands come through the 200-500 cap venues where I mostly work. People like Midge Ure, Nik Kershaw. They're still happily performing and touring despite (as far as I know) not being in Billboard top 100 for some time (tm)

So the fact of having been super-famous once and then not again is probably disappointing but not crushing, and no reason for other people not to try for the 15 minutes of fame
I’d add that from the park service’s perspective this is pretty simple. They don’t want to have people getting stuck in the backcountry or damaging trails, and as an agency with limited staffing, millions of visitors, and huge territory to protect it’s understandable that they do not want some complicated argument with every wannabe rules lawyer who thinks they can drive like they saw in the commercial. “Only 4WD” is a policy that doesn’t require training thousands of rangers around the country about which models are considered acceptable.
The neat thing about the Haldex is that with just a software tune you can substantially improve the performance of it. The hardware is actually far more capable than you'd ever know with the enormous amount of slack that's programmed into it from the manufacturers. Obviously this voids your warranty, but it's a fairly low-risk modification.
This points to a widely unspoken reason why people use vim/emacs instead of VSCode, JetBrains, etc. No one can take my editor from me, upon which I stake my livelihood because of some corporate whims. Neither do I have to pay a yearly subscription or worry about an arbitrary terms of service change after I’ve incorporated the tool into my livelihood.

Yes, I am aware that VSCode is open source and that there is a fork that removes Microsoft’s telemetry every release. Even so, there is only so much trust that can be given to an organization in charge of my main tools. So too have Anaconda users been bitten.
> Intel at the time was fabless

????????!
You've over simplified and created a major error. It's a common one though, so allow me to explain.

There is no single entity Google cares about. There is no "average user" (nor median). Trying to make the product best for an "average" user makes it bad for everyone. You have made the assumption that this solution space is smooth and relatively uniformly distributed.

Consider this: on a uniformly distribution, if you interpolate between two points, those interpolations are representative of the distribution. But if you do so on a gaussian distribution, this is not true. This is because the density of these distributions are not evenly distributed (this is what "uniform" in uniform distribution means). For more complicated distributions you need different interpolations. Many real world distributions are the agglomeration of varying distributions (you probably have clusters and pockets).

The distribution of searches (or customers) is neither normal nor uniform.

To understand some further complexity, it is important to remember that the burden of success is the requirement for further nuance. Pareto. It may take few resources to get to "80%"/"good enough" but significant to increase that another 10%. Think about a Taylor Series (Fourier Approximation, or pick your preferred example), the first order approximation will only take you so far. It may be good enough to start, but the need for higher order (and this more complex calculations) approximations are increasingly necessary for precision (non-linearly). So simplify where you can, but don't forget what you've done. If you do, you'll be stuck. Or worse, you will compound your error (also very common).
Agree with this advice. Our consulting agency, also based in Europe, specializes in exactly this - bootstrapping software solutions for companies that lack the in-house experience to do so. After a successful launch our clients usually transition to hiring employees to take over our work - a transition we actively support. It works out quite well in our experience. (contact/website is in my profile if interested)
Sure, let's benchmark it :)

It is consistently around 8% to 15% faster on 3.10.12 and 3.11 for me. On 3.12.5 (latest) I seem to get the same result.

https://www.online-python.com/B6AgKW5zod

(please copy the code to your local to not ddos this site :D)
>fixing the work ethic of American Semiconductor Factory employees

How do you pinpoint this to be the problem? How are you sure that it's not some narrative used by corporate to excuse outsourcing or putting pressure on wages?

I think an industry where technical knowledge was outsourced for cost cutting reasons for decades now is probably having issues because only the managers are left, and they're not productive on their own. Blaming it on the factory worker seems uncalled for.
Yes, indeed, I've checked, and apparently you don't need anything beyond this if you don't want super speed or power delivery (past 5V 3A).

I did not realize how many pins in a USB-C socket are duplicated to make this possible. (For advanced features, you apparently still need to consider the orientation of the inserted cable.)
> The current financial results have shown decent profits for the consumer CPUs,

Only after serious financial alchemy. The client group has a decent op margin, but the foundry group has an absolutely terrible one, and the client group sells products that they buy (internally) from the foundry group at arbitrarily set prices. What would the client margins be if the internal price they pay for their products was set so that the foundry breaks even?
AMD's stormed the castle with Ryzen long ago and planted their flag, but since everyone's still asleep at Castle Intel they haven't really noticed.
Sorry for the late response.

It may have been culture brainwashing, but we definitely felt more of an ownership vibe. We awaited the periodic valuations that the ESOP share price was based on and the process seemed relatively transparent.

An accounting and legal firm handled the dismantling of the ESOPs. We received a letter itemizing our shares and the value based on the company sales price. Then a few months later, we got a check (which you could have made out to your IRA management or whoever or to yourself if you were ready to pay taxes on it.

In the case of the company I’d left, I had to wait 6 years to get paid out (turned out to be about 4.5 because of their sale).
Do you think the average Andalusian and Neopolitan would disagree that all Southern Europeans share more culture and genetics than themselves and a German or Russian?
Can you explain how [4] breaks guidelines, please?

I can see how [1]-[3] might appear contentious, at a very casual glance - but the wording I used in [4] was on its own terms entirely innocuous.

All I'm saying is, basically -- "OK, so that's your position then" (while correctly and relevantly noting also, as you will confirm from the comment history, that they were conspicuously evasive in providing a straightforward answer up until that point).

The follow-up question about the abducted minors (in case you were wondering about that) was entirely legitimate and relevant, as it's one of the many (rather awful and nasty) complications of the conflict that people who think there's an easy "deal" involving territory that just be cut to end this thing typically aren't thinking of (because by and large they aren't following the situation too closely anyway).

They didn't have to answer it of course, but there was nothing uncivil about the question in itself, or my phrasing of it.

Also, you'll note that I'm very carefully and diplomatically defusing their completely gratuitous and uncivil provocation ("I'm not your bitch"), which I notice you did not flag or call out the user on, even though this (in addition to "Are we 12 year olds?", and calling it a "BS question" when it was the exact opposite) was obviously way more inflammatory than any possible reading of my posting.

In this case, you should be calling out the other user for their needlessly inflammatory rhetoric here -- not me, for my far more centered and non-escalatory response.

[4] https://news.ycombinator.com/item?id=41123755

See also: https://en.wikipedia.org/wiki/Child_abductions_in_the_Russo-...
Considering that we already don't have enough workers, no.

Has building more housing crossed your mind?
[citation needed]

It is very likely that blue collar hiring, firing, promotion, flexibility dynamics are entirely different to tech.

Tech competition might be much stronger compared to whatever competition exists in a very local workshop.
I don't think housing costs explain the short-term changes described in this article. I am only answering the question of how housing costs lead to population decreases.
It's been said many time and the correlation between ISA and power efficiency have been debunked many time. ARM is power efficient because most ARM implementation are power efficient. Right now x86 AMD strix are about on par with qualcom x elites
Context for that?
It's almost like people factor in a piece of software's tooling environment before they use the software - wild.
NPS defines 4WD specifically as part time four wheel drive with a transfer case and low range, FWIW. Low range is a big part of it. And yes, their definition technically excludes higher end "full time 4WD" systems in some cases, though I suspect everyone would look the other way at those.
Plus AWD can have locking differentials.
> they didn't try to fit a distribution or two?

Since mu is 28, and 13 is the min, you have 28-13=15 = 3*5, which makes sigma 5, so use rnorm(n,28,25) to generate n samples from the gaussian.
https://www.desmos.com/calculator/mlwm7mke16
With reference to previous absurd but technically correct interpretations of US national park rules[1] I'd like to suggest a way to comply with the rule in question [2], which states:

High clearance four-wheel drive
is required on motor vehicles
travelling on [...]

Take a 2WD vehicle, then bolt an extra set of wheels onto the drive axle (the tires are apparently optional).

The vehicle would still need to be high-clearance.

Or, if you're feeling really adventurous, just glue a set of LEGO wheels to the center of the hub. Those wheels would demonstrably have a high clearance, and comply with the rule as written.

1. https://news.ycombinator.com/item?id=36453856

2. https://www.nps.gov/cany/learn/management/compendium.htm
The fundamental problem of the great majority of so-called “in mice” studies is their use of exactly 1 (one) fully inbred type of mouse — C57BL/6J. Would you trust N=1 clinical trials?

In this particular PNAS study you have to be hard-core reader and rummage around in the Methods section to uncover this awkward detail:

“Mouse strains used were C57BL/6J (Black 6, Jackson Laboratory; JAX stock #000664), JAX stock #003725 (Gabrd−/− mice on a C57BL/6J background…”

No wonder translation fails so often. It is not the mice, it is scientists cutting corners!

Some of us working with mice use many different genotypes of mice to ensure somewhat more robust results that have a better chance to generalize across mouse genomes and perhaps even human populations.

This is not new news. Here is a classic on this topic in Alzheimer’s research published in Neuron in 2019:

https://pubmed.ncbi.nlm.nih.gov/30595332/

One more point: There is a great deal of variation in expression of key genes/proteins mentions in this recent PNAS study, in particular parvalbumin and the GABA receptors.

For example parvalbumin protein levels in the hippocampus of different strains of mice at different ages vary over a 20-fold range. Here are the hard data from GeneNetwork.org;

https://genenetwork.org/show_trait?trait_id=61839_VFHILDKDKS...

And GABA receptors also have high levels of variation in hippocampus and other brain regions. Here is a good paper that compares mouse and human GABA receptor variation.

https://pubmed.ncbi.nlm.nih.gov/22506031/
Love the subtitle: "At least it wasn't Novichok."
The effects of preprocessor in C are quite significant. Old DOS Turbo C had shown amount of lines compiled and the speed in the compilation progress window in the IDE. IIRC straight

#include <stdio.h>
#include <stdlib.h>
int main(int argc, char**argv){
puts("hello, world");
return EXIT_SUCCESS;
}

came to something ridiculous on the order of 100k lines.
Wouldn’t it be easier and less controversial to just build more housing?
Blue collar workers often also don’t have any parental leave at all and might even be required to work the day after giving birth. Is the argument that because they “make it work” that no group of people should ask for better working conditions?

I don’t think we should look to the worst examples of labor standards to decide what is fair. People with healthcare can “make it work” without healthcare. People who don’t have to work 996 could “make it work” if they had to work Saturdays. Even before OSHA, most factory workers weren’t losing their fingers in meat grinders.
Personally, I am not arrogant enough to speak for everyone else and you still don't actually know me needs, just one thing I use it for. What about the other people in this thread who gave the same reason as I did, getting both the androind and linux ecosystems in a single device? They are still brainwashed by google because they did not bother spending two days backing you into a corner?

Perhaps try talking to people before passing judgement, might find out the world is a whole lot bigger than you realize.
Why are you alive then? I hope you continue to stay alive, by the way, I'd just like you to examine your reasons for not having allowed your own death yet.

I wonder if it has to do with the fact that your current lifespan is "natural" and an immortal lifespan is "unnatural". But what's the difference between being alive in 10,000 years, and being alive currently? A person 10,000 years old may believe themself to be immortal but there's fundamentally no difference between being "currently alive" at 10,000 and being "currently alive" at 40. Either way, it's an experience of the present. So what makes living to 10,000 wrong, if living to 40 is right?
Thanks for calling that out!

Indeed, that is a well-written technical book that one could read cover-to-cover. It has a clear progression of topics, and all of the text is beautifully written:

"Once secure boot is enabled, the bootrom verifies signatures of images from all supported media: flash, OTP, and images preloaded into SRAM via the UART and USB bootloaders. At this point you lose the ability to run unsigned images; during development you may find it more convenient to leave secure boot disabled. The next section describes the generation of signed images to run on a secure-boot-enabled device."

"The chip-level reset subsystem shares a register address space with other power management subsystems in the always-on domain. The address space is referred to as POWMAN elsewhere in this document. A complete list of POWMAN registers is provided in Section 6.4, “Power Management (POWMAN) Registers”, but information on registers associated with the brownout detector are repeated here."

"The clocks block provides independent clocks to on-chip and external components. It takes inputs from a variety of
clock sources, allowing the user to trade off performance against cost, board area and power consumption. From these
sources it uses multiple clock generators to provide the required clocks. This architecture allows the user flexibility to
start and stop clocks independently and to vary some clock frequencies whilst maintaining others at their optimum
frequencies."

I am thoroughly impressed!!
Many of us, myself included, will be predisposed to controlling our own SDLC, largely because of bad experiences with vendors. Personally I've had vendors shutting down a product that was core to our offering with basically no notice, performing poorly but not accepting responsbility, just milking T&M, and just straight up lying.

The problem is, all those outcomes exist with hiring your own developers, and it's really difficult to mitigate unless you yourself are a strong developer who can run projects and teams and look beyond what people are telling you.

Reality is, it's impossible to answer the question without really getting more information. Specifically around what you spend on outsourcing / licensing, what the feature set you're going, what the budget for the new team would be, and what the expected outcomes and timelines are.

Without the context though, some quick fire opinions.

- You probably at least want the dry powder. i.e. the person making the outsourcing decisions should at least have the technical accume to bring it in-house if required. If they're not a person that could, then outsource is the only decision they can realstically make, then they'll tell you it's the right decision even when it isn't.

- You need someone mature. If they just want to build everything from scratch always because of some personal bias, you'll end up amassing tech debt in areas where there were limited risk / benefit. Developers will 100% tell you you need to building things because it's interesting to them, even when you don't really need it.

- If you're going to do this with any near-term success your first hires are really key, and they likely won't be cheap. I see people debating brining in a team vs a CTO, but both strategies fail if the quality isn't there. Figure out how to validate quality.

I was CTO of from ~25m to ~£75m ARR UK Point-of-Sale org with ~100 tech employees. Those roles are hard to find. This sounds like a great opportunity. Lots of folks will likely do the hard sell. Good luck.
It’s political theater. The tide is swaying towards US fabs. What about the past 15+ years? The capability is gone for a lot of it.

As Obama put it, “Those jobs aren’t coming back”.
Freedom to learn the language and customs of those who have more kids, who will then have more political representation and ultimately rule over you.

But well, no need to care about your kids' future if you have no kids.
kanye would be relevant just off music production making beats and fashion.

his outburst are hurting him more than helping him especially now that his quality has declined
Come on. We’ve got plenty of workers in this country. They’re just not willing to work for pennies (and why should they?)

Importing masses of unskilled labor puts downward pressure on wages. This is basic supply and demand.
> This really reads like a badly disguised hit piece against Elon, doesn't it?

No.

> the Guardian's owners should publicly apologize to all their readers if they get anything wrong

What, you mean they should publish corrections and clarifications in an easy to see way:

https://www.theguardian.com/theguardian/series/correctionsan...

You mean they should be aware of their own history and publish that too:

https://www.theguardian.com/media/2021/may/12/guardian-200-t...

> I doubt they do.

Why doubt? Why not simply see for yourself.
When I hit the text "single out humans for punishment and degradation" I immediately thought of the old chestnut about being so accustomed to getting whatever you want that restraint feels like oppression.
Flash = Haiku, Pro = Sonnet, Ultra = Opus
If you want kids, there are places to find people who are very interested. It's not Tinder.
That would mean lifting the Venezuela sanctions, Cuban embargo, and so on. I'm for it.

The US has a dry foot policy specifically for Cuba, encouraging people to seek asylum in the US.

The US involvement in Central America - from Honduras in 2009 and before that encouraged migration and asylum servers, but that bell is hard to unring.
This adds support for ephemeral EBS volumes. When a task is created a volume gets created, and when the task is destroyed, for whatever reason, the volume is destroyed too. It has no concept of task identity. If the task needs to be moved to a new host, the volume is destroyed.
There are some aspects of string theory that have never seemed to work to me from a very basic point of view. I mean from wikipedia

>the characteristic length scale of strings is assumed to be on the order of the Planck length, or 10^−35 meters

And in normal quantum electrodynamics, if you have two electrons a meter apart they repel by exchanging virtual photos which are presumably these 10^(-15)m long things. How on earth would they hit? There isn't an aiming mechanism I guess an if you sent them off all directions you would need like 10^100+ of them to hit etc. Which may sound silly like I don't understand it but I think beyond that it is silly because the theory is nonsense.

The way I see it it started as a real model of the binding between the components of the nucleus and then people thought the maths is cool, we can get grants to study that and then the grant getting community multiplied irrespective of it having any connection to reality.