skysight-inc/HackerNews huggingface dataset:
> The $1.1 billion figure is for Truvada total, not for PrEP specifically. It’s perhaps notable that Gilead chose not to break that down, given that the original claim they were responding to was about PrEP specifically.

And even then it's a dishonest claim. Half of that $1.1 billion is the amount of money they paid to acquire another biotech company in a firesale. It's beyond disingenuous for them to claim all of that towards the amount they spent developing Truvada, since they received way more assets in that sale than just the patent for one drug.
I'm surprised people are still making that argument even after the pandemic showed us the risk is nowhere near worth the reward. Regardless you need to create a vaccine for the discovered virus (which can take less than a week, as was the case with covid). And then you still need to go through months of human trials.

I was hoping we were done risking starting pandemics by purposefully creating new deadly viruses.
> People couldn't handle wearing a mask for any period of time without losing their damn minds

There is zero overlap between people who can't wear a mask and people we'd even consider sending to Mars.
It's remarkably disappointing to see this question downvoted. I had the same thought, but this makes me wonder if it's just a bad culture fit from the start. I've been Linux-only now for 15 years and haven't used an IDE in well over 10. I use vim (neovim now) exclusively. Given my characteristics, should I just squash my curiosity and do a pass on C#? Do C# people not see value in open source? Is there low tolerance in that community for people who have those values?
Yup, the author confuses security with protection and arrives at a the
"wrong question".

Security and reliability (also proximate "safety") are adjacent
concepts and very well aligned in most cases.

Of course allowing a trusted third party deep access to your system is
going to damage reliability. It is also going to damage security.
It violates the most basic trust models that underpin actual security.
They're also apparently incapable of breaking it in that specific way on newer phones. (force update that allows unlimited PIN unlock attempts, only possible on the 5c and below)
>Cellular damage has been demonstrated in every astronaut that has ever stayed on teh space station.

Yep, I really feel sorry for the poor suckers who flew up to the ISS on that p-o-s Boeing Starliner. They thought they'd only be up there for 8 days, not enough for significant physical problems to develop. Instead, it's now been 2 months, and they're now saying they might be stuck there until February!
Same energy as https://mastodon.radio/@wa7iut/112923475679116690
> without a guaranteed magnetic field having the evaporated water (hydrogen) get carried away by the solar wind seems like a bigger issue

This would be a problem that manifests on time scales orders of magnitudes longer than human civilisation has existed.
What I very dislike about current browser automation tools is that they all use TCP for connecting the browser with the manager program. This means that, unlike for UNIX domain sockets, filesystem permissions (user/group restrictions) cannot be used to protect the TCP socket, which opens the browser automation ecosystem to many attacks where 127.0.0.1 cannot be trusted (untrusted users on a shared host).

I have yet to see a browser automation tool that does not use localhost bound TCP sockets. Apart from that, most tools do not offer strong authentication -- a browser is spawned and it listens on a socket and when the controlling application connects to the browser management socket, no authentication is required by default, which creates hidden vulnerabilites.

While browser sessions may only be controlled by knowing their random UUIDs, creating new sessions is usually possible to anyone on 127.0.0.1.

I don't know really, it's quite possible I'm just spreading lies here, please correct me and expand on this topic a bit.
I wouldn't say "junk" but there's a bit too much fluff and filler. The noise-to-signal is high which makes it tiresome to dig through to the meat.

E.g.

> Browsers—we’ve all got a favorite, and we all use them daily. Even non-browser applications often load resources from external domains, like when using Google Analytics and similar client-side SDKs or embedding scripts or videos.

> With the 0.0.0.0 Day vulnerability,, a single request can be enough to cause damage.

The repetitive "Oligo [Researchers] [discovered/found] ..." adds to this.
Oh yea, 42nd Street Photo held 2nd and 3rd mortgages on my house for years.
It seems to be 4 displays; the marketing slides for the granite ridge explicitly list 4 displays https://www.tomshardware.com/pc-components/cpus/amd-dishes-m... . For Raphael it should be the same as the SOC is the same, I found some articles mentioning 4 displays but nothing directly from AMD quickly, they may have said it during a presentation
I wrote c# professionally for 8 years and now have switched to a codebase mostly in Java and some kotlin. I know some of this is learning curve but none of those things mentioned are anywhere close in JVM. Build systems, package management, close IDE integration for test runners, builds, etc. The ability for the IDE to even know what version of Java you want the project to run in even though it's defined in the project doesn't exist. Kotlin as a language does some nice things but even the syntax highlighting is better with c#. Async is trivial in c#. The orm makes it so you can write db queries in c# with Linq and not have to mess with SQL. SQL injection isn't even a thing I ever had to think about but now I have to write actual SQL inline with my code to do any sort of non trivial queries. Were using maven which is apparently older than gradle so maybe that is better but having to remember do clean then compile before any type of build required action has caught me with so many things. Like migrations or tests including non existent files. There are more things that drive me crazy but this post will get unreadable and it's ranty enough as is.
Names like this are so exhausting. See "Patriot Act" and "Americans for Prosperity Action".
For what it's worth:

https://x.com/Heroiam_Slava/status/1821274958879977633

https://x.com/Tendar/status/1821222650191982674

https://x.com/bayraktar_1love/status/1821219526668898710

https://x.com/Danspiun/status/1821218979811119558

Yes I agree, this has to be a limited Ukrainian operation, but the short term impact is still considerable. What the long term goal is, who knows.
No problem with this is it it does not interfere with infection. Only with replication. So it will not stop people from becoming infected.
> no sciernce that demonstrates that human life is viable on the surface of mars

Nobody claimed as much. You said "if life were viable [on Mars] it would already be there." To the degree we have science around this question, it seems to support the notion that transplanted Earth life could survive on Mars [1][2].

> Cellular damage has been demonstrated in every astronaut that has ever stayed on teh space station. Mars willbe the same. The surface is unihabitable.

Cellular damage has been detected in every person who has ever been tested because that's how multicellular life works.

You're not wrong about space being harsh. But you're again getting ahead of the science. We don't have real data on how human bodies work in partial gravity and partially-shielded extraterrestrial radiation environments. Anyone saying conclusively that Mars (or LEO or the Moon) is long-term habitable or uninhabitable is not speaking to the science.

[1] https://www.nasa.gov/news-release/nasa-designer-plants-on-ma...

[2] https://www.sciencealert.com/this-plant-is-so-extreme-scient...
You young whipper-snapper!

Why back in the day, we didn’t have ‘em new-fangled rotary phones. We had to tell the operator who to call!
how can we interpret that the legislature doesn't have a problem with chevron because they didn't draft countering legislation, but take the opposite approach when they don't draft countering legislation in the opposite case?
The time frame should (of course) match how long the information will remain valid.

And SSNs are for life aren't they?

So, it's not like the information is going to expire.
https://www.parkytowers.me.uk/thin/hware/hardware.shtml

From the above site I landed on the Dell WYZE 7020 / Zx0Q... Some models of which have 4 cores (also accidentally bought a dual core version), supports 16GB DDR3, are passively cooled without a fan, and cost me about $50 on eBay (add $20 for a 16GB RAM kit to bring the total to $70)

It's about as fast as a Raspberry Pi 4, and has been great for letting me spin up a docker container to play around with a database or a message broker or what have you.

I limited my search to only fanless designs though; if you are fine with fans then I'm sure there are more performant options out there.
Former Uber SWE apprentice in San Francisco looking for SWE I or II work - Ready now to contribute - open to learning new technologies quickly as needed - JavaScript is my specialty - my last experience was with Uber as an Android developer using Kotlin and legacy Java for a group of essential features in Uber's Rider, Driver, and UberEats apps. - Know Full-Stack JS and Mobile

Location: San Francisco, California
Remote: Open to remote, hybrid, or in-person - No preference
Willing to relocate: No
Technologies: JavaScript - strongest, Android - strong, Python - familiar, Java - acceptable, Kotlin - good, C - familiar, C++ - familiar, Ruby - familiar, React - familiar, open to learn new technologies OJT quickly
Resume: https://www.linkedin.com/in/reymercadousa/ - pdf resume available upon request, several references available upon request
Email: reymercado.usa@gmail.com
Phone or Video Call: Open upon request via email
Preferred method of initial contact: Email AND LinkedIn message initially - initial email can sometimes go to my spam folder unexpectedly

Additionally:
No sponsorship needed - US Citizen
Flexible with time zone difference.
Open to all salary offers regardless of size or stage of company
All offers will be considered.
My priority for work is to start sooner rather than later; ideal position for me starts immediately.
Eager and enthusiastic to be an immediate contributor and grow with your organization.
Brings to table experience of working as SWE at Uber as an apprentice 2022 - 2023
Studied at Hack Reactor and Code Fellows after pivoting from middle management and after graduating from UC Davis with a BA in Economics.

Miscellaneous/trivia: ENTJ/INTJ, lived in Germany and South Korea in former career, born and raised in San Francisco, California. Former Toastmasters Club President. Former US Army officer. Very experienced world traveler - 30 countries visited so far. 100% dedicated to the craft of software engineering.

Contact me: reymercado.usa@gmail.com and/or message me at https://www.linkedin.com/in/reymercadousa/ - ready now also for phone call or video chat upon email request
Ensembling is okay, but it doesn't scale great. Like you can put in a bit more compute to draw more samples and get a better result, but you can't keep doing it without hitting a plateau, because eventually the model's majority vote stabilizes. So it's a perfectly reasonable thing to do, as long as we temper our expectations.
The fact that the main way to achieve an outcome in the US is by changing the process is the outcome-vs-process dysfunctionality. It's not short-sighted thinking, it's realism. The US politico-legal environment has far more respect for process than for outcome, so processes have been co-opted to serve political purposes and if you try to simply follow the existing process or set a neutral process then you'll always lose.
India's Second-Tier Cities Are Driving EV Sales Expansion
But why ?

Is there any conceivable advantage to overstuffing the planet with an excess of population, particularly when they'll need to be supported with supply pipelines so well crafted there's no margin of error that doesn't kill a few million (less than 1 percent!!).

I get the techno sci fi "because we can" argument, where's the grounded rationale?
Yep. Where I work there are _a lot_ of efforts underway in that direction. Put simply, standard transformers are great, but they’re very expensive, both to train and to do inference with. They also need enormous datasets. We need architectures that are compute and sample efficient, and friendly to hardware. A standard transformer ticks none of these checkboxes, and research is needed to actually be able to make money with these models. And because profits depend on this research, it’s going to bear fruit. The field is vast and relatively unplowed.
Android lacks Crostini and Linux on Android options are no where near as good as Crostini. If I go laptop I lose Android apps. Both are less capable for my needs even if they have better specs. So I can carry two devices or one that does everything I want.
Just started a book on the American Occupation (Architects of Occupation). It's interesting realize that the US at one point was able to rebuild a society from the ground up. They took the lessons from Versailles and made a peace (and society) that lasted for a surprisingly long time.

That success in Japan and Europe probably emboldened the B team, who went on to handle regime change in Central/South America, the Middle East, and Southeast Asia.

That's the difference between reading the book and reading the cliff notes, presumably.
The Apple side is the similar: their current entire business is to middle man your relationship with other companies. You buy Apple products, purchase and subscribe to apps and services from the App store, use Apple Cloud, etc.

They need you in their ecosystem, the same way Google needs you in theirs.

And I totally agree with you, I wouldn't't call Google privacy focused, and I don't call Apple privacy focused either, even as they market it harder than anyone else.
After all the fiascos of companies changing the license on stuff, I’m a fan of what Linux. No copyright assignment and lots of contributors so relicensing is nearly impossible.
> Scots is an English dialect, descended from Northumbrian English.

Not being familiar with that term I looked it up [0] and was surprised by how familiar much of the vocabulary sounds to me, and i'm from south west England... I recognize a number of these words from my childhood (although not so much these days), and many others feel more like an natural accent transformation of a standard english word (although I suppose that might not be the etymology). Admittedly a good chunk of them are completely alien to "standard english" and whether you recognize them or not is more to do with exposure.

[0] https://en.wikipedia.org/wiki/Northumbrian_dialect#Vocabular...
That will greatly disappoint Elon Musk.
Cool. When I've looked at those they seem decent, but more expensive than putting similar spec'd equipment in co-location (with Hetzner) and let it depreciate over a bunch of years.
My guess is that the issue is more related to the constant high temperatures rather than the battery state of charge, which this wouldn't assist with.
Mouse Pong: play a game from mouse's firmware with persistence of vision cursor
> Buy why ?

The only reason I can come up with is a dictator raising an army. In that sense, a human is a cheaper drone.
The former status quo existed for about four decades, the new for about a month. I don't think we can read much into it at this point.
Where does sqrt come from? Shouldn't it be log? I don't know much about DHTs, but Kademila (BitTorrent's DHT) has query complexity of around O(log n), with n being the total number of nodes in the network. Kademila also uses random node IDs and XOR disrance metric.
My company has hundreds/thousands of ecommerce clients, of which a huge portion use Stripe and we do real card testing every time we deploy code that could affect payments and its never been an issue.
Same with software. I saw IntelliJ costs $250/year but it costs almost nothing to send that file (it's like maybe 1 GB max, cents). You can get it from generics manufacturer on TPB but updates are not as frequent.
Visualizing Data from the 2024 Paris Olympics
A brief interview with JSON creator Douglas Crockford
> What Are the Olympics Shooting Competitors Wearing on Their Faces?

The cool ones? Nothing.

The best meme I've ran across regarding Yusuf Dikec is this [1]. Nobody should be messing with Yusuf Wick's cat!

[1] https://www.youtube.com/channel/UC8DIU56jF1ev5c6ubG_2IEQ/com...
"I picked the cotton, I carried it to the market, and I built the railroads under someone else’s whip for nothing. For nothing."
this has burned in my brain.
The public gets the privilege to be price gouged for stuff their taxes paid for. Doesn't sound like a good deal. Many will not have access at higher costs. Price gouging restricts access.
>Insofar that it's true that "a strong military is a requirement for a free society", it's because people like that exist.

Yes, but there's no way to change that; it's human nature. Without a military, other countries with strong militaries will happily impose themselves on you: Nazi Germany, Russia/SU, etc. History is full of accounts of what happens when people don't have enough military power to resist invasion by a country of evildoers with their own powerful military.

Similarly, police frequently suck, but the alternative is even worse. There's no shortage of people who would be happy to ignore laws and prey on others if they didn't have to worry about police enforcement.
Everyone and their mom in advertising sold "GPT Persona" tools which are basically just an api call to brands for target group simulation. Think "Chat with your target group" kinda stuff.

Hint: They like it because it's biased for what they want... like real marketing studies.
> Seizing the plant and rigging it to explode as a quid pro quo demand for Russia to leave the Zaporizhia NPP

I honestly don't see that happening. There's a diplomatic game being played around Russia's nuclear threats, I don't see Ukraine being so dumb as to undermine that.
The Illusion of Being Stuck
Typescript is pretty competitive with C# on those factors in my experience. What do you find yourself missing there?
I wonder what kind of impact this will have on boss-ware. Will there be ways to override this from an administrator point of view?
The Philosophy of One Piece: Finding Meaning in a World of Pirates (2023)
I’m sure this won’t come up at all during any litigation…

https://www.theverge.com/2023/11/29/23981928/elon-musk-ad-bo...
HN is, unfortunately, now sadly inhabited by many un-inquisitive cowards.

Why is collusion of buyers (group influence over supply) not fundamentally different than collusion of sellers (restriction of supply)? I don't agree with pretty much anything being done, by either side, but it's interesting.

It used to be much more interesting, here; filled with people who asked "why" things occur, and if things form coherent patterns, what this could mean?

Now, it is evidently a boring leftist DEI soy-boy echo chamber. If one engages in wrongthink, one gets silently downvoted, evidently by people who hold opinions they cannot robustly support...
In this case it's more the reverse. Insecurity by obscurity since by default its secure but they are making it harder for people to make less secure.
>Once the Germans attacked Poland and the Japanese attacked us, how would you have solve these problems without violence? Ask Neville Chamberlain how that worked out.

To be fair to Neville, there's an argument that he did the best he could, and was really just buying time because the UK was in no position to go to war with Germany at that point in time.
The report linked is concerned with more of the auditing side of the industry, which often claims to guarantee 100% brand safe placement. But which obviously does no such thing.
So my spouse and my kids now need me to shop at Costco all the time?
It makes sense as a general behavior since it suppresses flamewars by hiding the original bad post that kicked them off along with the replies (that are likely flames). The downside is that when HN posters perform well, they're responding to bad posts with good posts, and the good posts get suppressed.

The alternative (sparing rampant flamewars to rescue the occasional good-reply-to-a-bad-post) would probably add fuel to flamewars.
I don't think "replicate" is the appropriate word here.
> One also has to include the money spent by small companies that failed and were not bought out, not just the money the big companies spend buying the successful ones.

If you're looking at the total amount spent by "the economy" (drug development costs X% of GDP), sure. If you're looking at "why are drug prices so high", it probably doesn't make sense to to include costs funded from other places (which in this example I assume would be research grants ie taxes, and venture capital funds).
> 1) They can't push software to my computer, because I've blocked the software update mechanism with Little Snitch

They can because they (Apple) run in kernel space and Little Snitch no longer does/can. So LS, god love it, only works because Apple lets it. If Apple wanted to they could push updates to your OS without LS knowing about it.
It's true. Harvard education costs $300k, so that engineer's lifetime earnings can be $300k plus some small margin so that he does not price gouge. Community college engineer can be paid $2k+small margin.
Yes, because a military would not be effective at all if every soldier got to question every tactical or strategic decision. That's why it's your job as a citizen to pick better leaders, because those leaders are in charge of the military.
https://www.elektronauts.com/categories has "Marketplace" category once you're logged in, bunch of music fans there who'd be happy to purchase it I'm sure :)
I'm way out of my depth here, but I think this comparison to the birds of paradise feathers makes the most sense in terms of me visualising what Nxylon would look like with a thin metallic coating
Your organization appreciates your efforts, but they believe it's time for a change to invigorate the team with new creative ideas and innovative approaches.
and critically, the suspicion is that they handed off the keys for iMessage encryption used inside China. And if they did it for love of money for China, would they really not do it for the right US government inquiry?

Google's better in that they chose not to do business in China the same way. For now.
The thoughts described in the article sound a lot like OCD. Which is very common, so may actually be a common expression of OCD.
Payment Request browser API is a faster more secure version of form payments
Sure, people find different things complex.

For example, I can't make heads or tails of rxjs, and honestly have zero motivation to do so.

Other people see it and find it intuitive.

Shrug.
Your spouse can get her own card.

Having said that, this will probably piss me off. Why can’t the cashier do this and deny at the time of purchase.

Costco’s customer friendliness is why I shop there, and this is not customer friendly. Seems like a bean counter had a brilliant idea. /s
The nub > trackpad
MG-3 would be perfect
It does in fact prevent infection you have misunderstood.

It very clearly prevents infection incredibly well, proof of that in the real world is exactly why there is excitement over this drug.

It also sounds as though you misunderstood the mechanism, it interferes in both an early and a late step in the viral process, there no theoretical reason to describe it as "not interfering with infection".
How to let go: one life ends while another begins