skysight-inc/HackerNews huggingface dataset:
I'm not a biologist, but I'm guessing that having the concentrations of two antibiotics peak at the same time etc is much much trickier than having one molecule with two mechanisms of effect. Thus in actual (not perfect) use you end up with both effects active within a bacterium at one time, rather than potentially having some distance between the peaks.

From the article, it does look like they're smushing two antibiotic active sites into one molecule, so it seems a somewhat similar idea
The problems you don't even acknowledge are there won't ever be resolved nor addressed. Sure, you can keep ignoring them, but as life goes on the pile of stuff just sitting there that you constantly have to keep looking away from grows significantly. Not life I want to live, nor a parent I want to be.
Regarding the name, doesn’t it implify fuzzification of data?
This isn't quite what you asked for, but as a kid who grew up on Lego Mindstorms I would have loved to have Spintronics back then:

https://upperstory.com/en/spintronics/

This is more about learning about electicity in a tangible physical way, using puzzles to learn -- so it's maybe a level lower than your intent, but it is for kids 8 and up and seems like even adults could learn quite a bit from it.

It's really hard to describe though - I strongly recommend watching the video at that link or at least looking at a picture.
> but when they do say Russia

Israel is already calling for an act of sabotage by Iran. Turns out you should have used an "if" instead of "when".
Very open and detailed explanation
> Yet. One good-size war could flip that.

arguably that's what the stockpiles are for
The same argument could be made for any software.

I disagree, cars should be fully updated OTA. It's cheaper than a recall and easier for the consumer. New features increase the longevity of the car.
This is very strange. How do you go from "Here have my 135Bn" to "You Get Nothing!"? I wonder if there's more of a story behind this given all that went on with Epstein and the divorce. Even then it seems very strange to hand all the money over to his kids and require unanimity. Either they'll end up deadlocked or basically splitting the cash 3 ways and splurging on their pet projects. I wonder if this ends up massively inflationary in some weird ways.
Any appraisal would base NOI on Net Effective Rent not Face Rates, so asset book values would not really be affected by shifting more shortfall into rent abatements or tenant improvement allowances.
I think what we need to look at is that AI systems were not able to do it before and now they are able to do it. Sooner these systems with millions of dollars of compute will just scale the algorithms and beat humans at this as well - just like they did for chess, go, shogi etc.
Yeah, but both can be true. It can be possible to build a walkable suburb with SFHs and a downtown. That's how older suburbs in Baltimore, Northern NJ, DC and others were built.

My biggest issue with suburbs is that they are all built around the car being the ONLY method of transport. Public transit options are essentially non-existent and walking is extremely impractical due to everything being planned around cars.

When you combine this with the suburbs being cheaper than living the city, you get people who are, rightfully, pissed about the conditions they need to live in.
Egyptian pyramid may have been built using a water-powered elevator
> Fix problems the way they're normally fixed
I think that's the problem. Putting your car into a garage to get it looked at and fixed is expensive to the manufacturer and the loss of time to me.

As opposed to my car getting an OTA update overnight and the only thing I notice is the reversing beep is now a slightly different tone.

That's progress to me.
> Because of this, it should be mandated that 3rd parties be allowed full hardware access/documentation once the warranty period expires.

Mandating that would also mean the 3rd party also would have to take responsibility that the updated software conforms to spec and doesn't kill someone. Who's going to pay for that?
I know, but it just doesn't matter enough. Believe me, I'm signed up to the idea of theoretical rigour, the argument for soundness is part of what originally won me over (along with previous good experiences with Flow on a smaller project, and the support for gradual adoption). I will continue to be drawn to languages and tools that have a strong theoretical foundation. But in this particular case, today, when comparing these particular projects in the large JavaScript codebase I am talking about, TypeScript still wins by some distance. I promise that it has caught way more errors and been more generally helpful in its language server abilities than Flow ever was. Maybe Flow has caught up since then in its core functionality, I haven't been keeping track, but there would still be the wide disparity in community support which has serious implications for developer education, availability of library type definitions, etc.
Power-hungry data centres scrambling to find enough electricity to meet demand
Why global tech meltdowns such as the CrowdStrike outage are the new normal
China emerged by building and selling. Part of the rise of china has been the extraction of wealth, resource, and knowledge. I don't say this with any shade, any emotion or feeling, just very literally. A large component of the ability for china to move forward so quickly was the creation of funnels that allowed for exchange. The west mostly extracted the labour and china extracted a bunch of other stuff. I can't think of a better word to describe what literally happened, and again, I'm not saying it with an opinion (that would be another discussion).

Without any judgement, imo: China is good at creating extractive systems.

(I'll add, if you've not read it, "Dealing with China
An Insider Unmasks the New Economic Superpower By Henry Paulson" is a fantastic book)
No, please re-read.
and 25% markups on everything else.

housing bubble is also looking shaky, so build up reserves of stuff now so that if things get weird you can offload some of the reserve to stabilize prices and help recover. also useful if/when China feels a need to invade Taiwan, an increasingly likely prospect.
No. Just look at the postmortem engineering reports on bridges which have collapsed (due to crappy inspections and maintenance, or being hit by a vehicle, or fire, or ...). Understanding which parts of rusted & crumbling old bridges are critical (to keeping them standing) is extremely important. Because the real world has many, many such bridges. And even fresh "Rescue workers are still pulling bodies from the collapsed bridge!" headlines seldom motivate the politicians to provide enough resources for inspections & maintenance & protection.
India ditches its 'Google Tax' after US waved a big stick
McWatters Home

We’ve been operating privately in Arizona by invitation. It’s ready for general availability, but not terribly useful to people outside of AZ right now.

We’re ready to start rolling out to other states and include their registrar of contractors’ directories.
Most importantly, it saves the real backdoors for American intelligence partners and the Chinese government. That way, it's only the citizens being spied on and not the puritan parliament members or Congresspeople.

The first rule of iPhone security is that you do not control the attack surface against a sufficiently large government.
That would be weird. I rant a lot about spirituality and religion and it doesn't show up. But that one time I talk about pregnant man emoji and now I'm the reference for that.
There's the term "white flight" for a reason.
(Not GP.)

NixOS can share its Nix store with child (systemd-nspawn) containers. That is, if you go all in, package everything using Nix, and then carefully ensure you don’t have differing (transitive build- or run-time) dependency versions anywhere, those dependencies will be shared to the maximum extent possible. The amount of sharing you actually get matches the effort you put into making your containers use the same dependency versions. No “layers”, but still close what you’re getting at, I think.

On the other hand, Nixpkgs (which NixOS is built on top of) doesn’t really follow a discipline of minimizing package sizes to the extent that, say, Alpine does. You fairly often find documentation and development components living together with the runtime ones, especially for less popular software. (The watchword here is “closure size”, as in the size of a package and all of its transitive runtime dependencies.)
> It was designed to solve "hyper" scale problems

Even then, IMO, it makes too little sense. It would be a bit useful if non-used containers wasted a lot of resources, or if you could get an unlimited amount of them from somewhere.

But no, just creating all the containers you can and leaving them there wastes almost nothing, they are limited by the hardware you have or rent, and the thing clouds can rent are either full VMs or specialized single-application sandboxes.

AFAIK, containers solve the "how do I run both this PHP7 and this PHP8 applications on my web server?" problem, and not much more.
Nothing, to you. But commercial places are commercial. The idea behind a suburb is that the only thing near you are your neighbors, and a few amenities such as churches and parks and elementary schools. The sound of a party or of children playing is not noise. Even the drone of a lawn mower is not noise. If you can smell your neighbor’s fertilizer, then you don’t live in a suburb (or he used way too much and killed all his plants).
Show HN: I built the Stack Overflow of SaaS growth ideas
Internally mutable types are allowed, but doing internal mutation isn't.

So a const function can return a cell, for instance, as long as the cell isn't mutated inside the function.
That's difficult with oil though.
At least my airbags aren't stolen every few months like with some brands here since the manufacturer made it hard to swap them between cars.
> For me the real test is whether or not someone is trying to persuade other human beings towards a certain action. An action that is favourable for you.

I think the test for me, at least for the kind of marketing/advertising that should be banned, is the passiveness of it.

If, while going through my day, I am interrupted by your billboard, banner ad, spam email, promotional app notification, street marketing person, etc. in an attempt to manipulate me into action, that is the thing that should be illegal.

If I walk into a shop and say "I'm looking for a camera", invite a business in to pitch for work, call somoene up for a quote, directly enter a query like "buy camera uk" into a search engine, etc. then I think that is ok. I have asked to be sold to, and I am mentally prepared for the fact of that happening (notwithstanding that certain techniques should maybe also not be allowed).
we are talking about lean proofs. Given a formal statement and a proof - the lean can verify whether it's correct or not. It's like generating computer programs to solve a problem - the problem lied in generating useful solutions/sub-solutions so that the search is effective. They achieve this via using gemini as a lean proof generator aka. using a world model LLM fine tuned to generate lean proofs in a more effective manner.

Humans are even better at this as you mention - but effectively the approach is similar. Come up with lot of ideas and see what proves it.
It’s funny how the market works that way, right? The smartest engineers I know aren’t the ones making the most, and that carries for a lot of other things too.
I've traveled fairly extensively around Europe and you do indeed need a credit card in the majority of cases. Some rental agencies will accept a debit card but it's risky to just turn up on the assumption that they will. You can find yourself without a car or forced to take up very expensive excess insurance. I've personally had this happen to me more than once and I now travel with a credit card which I have just for car rental purposes.

When you book a rental car through an online comparison site, you will almost always see in the small print that bringing a credit card with you is one of the requirements.

If you're taking out insurance by default then you may not notice that this is an issue because you're effectively paying to reduce the excess to £0 instead of blocking a deposit on a credit card for them to charge from in the event that you damage the car.
I thought “corrupt Winamp skin” means it's infested with digital parasites feeding on the RGB values of the pixels, making them look like rusty metal or rotting flesh. But this isn't bad either.
DARPA Brings Next-Gen US Microelectronics Manufacturing Closer to Reality
Ok, so why Israel can participate in the election as Israel ?
Paris was the only city too for 2024, the only other city was Los Angeles who will host the 2028 Olympics. They won the contest together and the two cities decided together which one will host the first of the summer games. Los Angeles didn't really care about the year so Paris stick with 2024.
Back in the day the euphemism was "trustworthy computing". That may be a good thing to Google to find those emails. I remember then too. Another name was "palladium"
But if doctors don’t always prescribe these two antibiotics to be used in tandem, then microbes will have an opportunity to evolve resistance to each one in isolation, putting those resistant genes out in the world. Whereas in this case, any bacteria ever encountering this drug will be hit by both mechanisms at once.
Not to join the hate train but it probably isn't better than Terrence Tao at solving the problems either, since this Tao would have probably been able to solve the problem himself and would have probably taken less time. There were participants in this contest that were better than the AI.

Still, an impressive result for sure.
I'm seeing my career basically go head first into .NET despite my attempts at going all in on Python, Visual Basic 6 was my first language followed by C#, and in college, the moment I learned about preprocessor directives in C I did what probably everyone who likes BASIC and learns C has done, define BEING and END as { and } respectively... to the horror of C developers everywhere.

I think .NET is a fantastic platform, and I'm still surprised there's not more attempts at building languages on top of it, especially when you consider how IronPython was built to "prove" .NET was a terrible platform, but the Jython developer fell in love with .NET as a result of his attempt, heck, Microsoft hired the developer! At least thats how I've heard the story told on random HN comments over the years. :)

I havent had the pleasure of building a full interpreter yet, so props on doing the work.

Edit:

A few weeks ago I tried VB .NET and theres something nice about it, it feels like when I write some pieces of code, I can verbalize what it is, instead of some obscure character someone gave a meaning to, but building out VB .NET projects means translating C# to VB .NET the entire time, since most .NET things today are all in C# and it can be more effort than just writing in C#. There is something really nice and almost elegant about BASIC.

My only complaint with Microsoft was that VB6 made native binaries, I wish they had done VB7 with threading support before .NET became a thing.

I REALLY hope they open source Visual Basic 6 with the MIT License, would love to see what might happen if people fork it and make improvements to it...
There is still a qualitative difference between reading

x.y = foo(z, t)

reading as "there is a variable labelled x, with a defined type within this scope, that contains a struct member y with a statically-computable offset within x's known memory layout, that will receive a copy of the function foo (which is known at compile time), which is the result of calling foo with a copy of z and t, which are also values with compile-time known types and layouts", even if you as a human may have to look up foo to know what is going on, and the equivalent in Python, which I will break out into a separate paragraph because this is going to get long even though it will still be incomplete:

"there is a reference x to an unknown type, which we will call one of several methods to resolve a field called y, where each of these methods may have been dynamically modified by previous code to not match their source implementation, which may either be a concrete value or a "descriptor", which will will have some method call performed on it (with full OO resolution rules on the method call, including the ability for the class structure to have been dynamically modified by code at run time and also all methods in the class structure to have been dynamically modified, and also the method can do anything a method can do including its own further dynamic modifications to arbitrary other structures, and also the result of running class and method decorators on everything in this hierarchy) with the result of calling foo, a values of unknown type that may be a function, method, or arbitrary values with a __call__ value (which itself may perform arbitrary dynamic operations in the process of returning a callable value), with copies of a reference to the values z and t of unknown type and capability, which will be filled in to foo's argument list in additional possibly complicated manners based on foo's definition and whether it uses args or kwargs, and also all of this code including the very statement under question may not exist in source at all because it may have been 100% dynamically constructed at run time itself."

And I probably missed some things in the Python too, but even so, Python already has numerous "and actually literally arbitrary amounts of code could be running here", and can readily introduce more.

All languages have the issues where you might have to resolve a function call as a human to know what is is doing, but in some languages, you're nearly done after that (C, Go) and in some languages your journey is just beginning (C++, Python).
There are a large number of cardiologists who advocate patients for invasive surgeries they don't require so that they can make a bit more money.
>> Would "quadtree" be the keyword here?

Quadtree is one option, and would be my choice for 2D. Most people seem to prefer other structures for various reasons. You may also look at BSP trees, BVH or nested Bounding Boxes. There are others as well.
The antibacterial resistance is often on small DNA loops called plasmids which are often and easily exchanged between bacterial species. I assume this has to do with that, either the resistance would have to develop twice in the main genome or twice on the same plasmid.

In the normal dual antibacterial cases just developing a single resistance and acquiring the right plasmid is enough.
The whole recent crop of extendable editors (atom, vscode, zed, etc.) seem to have been created by a younger generation that never used emacs (and are perhaps scared of it because they find Lisp weird) and so are reinventing the wheel.
Does it handles multiple input documents for extraction?
No, they literally wanted peace after coming home from a horrifying world war. Or from a horrifying non—world war.
Good question. Take many many antibacterial molecules to kill a bacteria, so there are two plausible methods. The first is that two compounds can have different pharmacokinetics. That is to say, they move through the body in different ways and have different concentration profiles.

The second is about how they are used. Two separate compounds with the same pharmacokinetics could be effective if you use them in parallel, but you have to contend with the fact that real human users may not always use them that way. If two different companies make compound a and compound B, it is virtually impossible to prevent someone somewhere from using them separately
Flying high to enable sustainable delivery, remote care
I'm a European enjoyer of car restrictions.

You have a distorted view of what "modal income" is. If you can afford to live in the suburbs and drive one car (per worker) into the city, then you are rich. The poor live in the periphery and walk, use PT, or carpool. Then, the ultra-rich can afford to live in penthouses in the financial district and will always weasel a way in to be able to drive (or get driven) in a SUV, they are irrelevant to the discussion.

You are relatively rich and want to have your way with your car and driving, and are using the poor as a bad excuse.

What do you think will happen, that the system will collapse? Trains and buses spilling with people, no essential workers, police and healthcare unavailable, chaos, anarchy?

No! Everything goes on normally in cities that have restricted car traffic. Because restrictions are gradual. If a job offer in the city center becomes less competitive (considering time and money), then it will attract different workers from better locations. And same for housing.

> And yes we can increase density. Amsterdam only has 3700 people/km2. The metropole only has 900 people/km2.

Sure, if you want to make everything worse, you can keep dialing it up until it's too late. See any other major city in the world. There's an upper limit of what is acceptable, there not really a limit in decentralizing.
The existence of suburbs was heavily driven by racism, and some suburbs are still.
Well, the French never had confidence in their government but it is down.

Slide 22 - https://www.sciencespo.fr/cevipof/sites/sciencespo.fr.cevipo...
2024 U.N. World Population Prospects report
I think the 4-color theorem is rather different though. It reduced to a large number of cases that can in principle each be verified by a human, if they were so inclined (indeed a few intrepid mathematicians have done so over the years, at least partially.) The point of using a computer was to reduce drudgery, not to prove highly non-obvious things.

Thinking back to Wiles' proof of FLT, it took the community several years of intense work just to verify/converge on the correct result. And that proof is ~130 pages.

So, what if the computer produced a provably correct, 4000-page proof of the Goldbach conjecture?
> I'm not very good at predicting how long things will take

Very few people are.

Unless you've done another project that is very similar, any estimation is going to come with a very large error bar, because you don't really have enough information to make an accurate one. There will be unforeseen difficulties, both technical and not, that weren't part of your estimation.

What I tend to do is to sandbag my estimates, to allow room for the unforeseen. So if I really think it's going to take two months, I'll estimate four and it will usually take about 3.5.

Which brings me to my tip: the reason I double my "honest" estimate is because I've paid attention to projects gone by, and observed that things tend to take about twice as long as I think they will. I'm guessing other people would have different correction factors. Pay attention to history to discover yours.

Also, I make it overt that my estimates are "man hours" and not calendar time. In other words, it's my estimate of how long it will take if I'm literally doing nothing else. In reality, I am doing other things as well but trying to estimate around that fact makes my estimates useless.
They drive
just curious, how do you do this in emacs?

I can jump from function to function across files, but it's not showing the whole function chain / path in 1 view
Midjourney AI Personalization: Unlock Your Own Unique AI Style
and there's a slight runtime difference between typescript classes and javascript classes
Any nation that becomes captive to ideological selection for its key sectors will naturally tend to selecting subpar individuals in position of power.

This is a cautionary tale. The same thing has happened to our nation, America, with the attendant decline across the board over the past 20-30 years.
Thanks for posting these resources.

I've been meaning to look more deeply into the field. I read a popular science book on it in the past and always desired to ascertain a more formal understanding.