skysight-inc/HackerNews huggingface dataset:
An interesting fact is that as long as there is a shortage of a compound, pharmacies can make a version using compounding. If demand always outstrips supply, compounding will be permitted.

https://kffhealthnews.org/news/article/glp1-compounding-phar...
This is brillant and I found papers I could not locate previously through manual searches.

One thing that I would like to suggest (other than saving to PDF, as discussed elsewhere in the thread) is to give the possibility, not just to "expand" the search, but also to "refine" the search.

If it was possible for me, after reading through the result page, to go back to your conversational UI and say, "OK this was my original intent, and here's what's wrong with the results I've got" for your system to provide a "refined" version of my query, that would be next-level.

Keep up the good work. Congrats on a successful launch!
I think there is absolutely a moral issue with these drugs but it's not the usual "personal responsibility" nonsense.

The problem is it makes it far less likely we'll address our poisonous food system. The US subsidises (crops including those that produce) HFCS to the tune of billions. Fresh fruit and vegetables aren't subsided. Advertising has been shown to impact consumer behaviour in other countries.

These drugs are, provisionally, miracle drugs. But they must be paired with regulation otherwise whatever addictive poison the industry comes up with next will repeat the cycle until everyone on earth is on them.
i’m not sure why an article describing the modern day accidental omission of NZ in maps is really relevant. they also often exclude Antarctica - not from lack of knowledge of the existence
Yes. It seems bizarre to me to apply for a programming job without knowing how to program, but when I just screen based on resumes there’s usually 10% who can’t do basic things like “write pseudocode to reverse a string” or a fizzbuzz loop.

So my brief exercise has saved me from wasting interviews on those folks. Of course it’s not foolproof and people can have a friend write it, or use ChatGPT, or whatever. But it helps.
Funny you Segway into drive thru fast food. When a crappy meal costs 10-20 bucks there and they forget your cheese or meat or i can basically get three times the food that's much better at a local diner or make it myself - my choice is very clear and it's not to eat fast food anymore.
They have so many issues with theft in the UK, which in turn pushes up insurance rates/reduces the pool of insurers that Jaguar Landrover have started offering an insurance product https://www.fleetnews.co.uk/news/jlr-takes-action-to-stem-ra...
Workflow Engine for In-Silico Biology
Hi everyone,

We are building an open-source platform NoLabs, which is designed specifically for running in-silico experiments with bio AI models.

We are building a platform that provides a user-friendly interface, APIs, and an AI copilot agent to streamline work with:

-Biological data access
-Protein folding models
-Protein solubility and function prediction
-Binding site prediction
-Protein-ligand docking
-De-novo molecule design
-Single-cell gene expression prediction
-Various other bioinformatics tools

The aim we have in our minds is for NoLabs to significantly enhance bioinformatics workflows by saving time on repetitive tasks and speeding up experimenting process. Eventually we are aiming to reduce operational costs, simplify bioinformatics pipelines, and offer seamless access to state-of-the-art models without complex setups.

Check out our 5-minute tutorial to see our interface: https://youtu.be/DF1_q8qBdmM

Additionally, you can explore our platform on GitHub for more detailed information: https://github.com/BasedLabs/NoLabs

We’re excited to collaborate with pioneering researchers and developers. Right now we are looking for a lab to work closely with to fine-tune the platform for them and see what kind of things it would be cool to add or improve, so if you are doing some bio research and interested in using AI models for biology please feel free to reach out!
Compare Oracle Database Hashed Passwords with Plaintext String
The "failing to lose" group should be very small, these drugs are very effective. The main reason to discontinue will be people who have reached their goal weight, many of whom unfortunately will gain it back after stopping the medication.
> other than being tied to Apple frameworks

Swift is not tied to Apple frameworks. At all.
It is fully compatible with them because of its full ObjC compatibility, but that’s it.
It's an interesting question (how much density is "right" for productivity apps).

On one hand, I still hate the MS Office "ribbon" UI to this day and much prefer the denser and more compact Google Docs or even Open Office layout.

On the other hand, Sketchup was hugely popular and very easy to use compared to its peers when it was released, and quickly became the de facto tool for simple free basic 3d modeling, in no small part because of easy and clean it was, I think. But they got bought out and then abandoned, I think? It doesn't have anywhere near the power of the other software anyway.

IDEs are another example. VScode seems a lot cleaner and leaner than old IDEs, and Jetbrains ended up copying them too (a controversial change, of course).

Photoshop is the one that always gets me. Twenty years of using it and I still can't get used to its layout. It's just so many different weird widget types mashed together in a way you don't see in any other software. I much prefer a docked toolbar like in Figma or Paint Shop Pro. I hate that I use it... I feel like a hostage every time I open it.
There are drugs that can counteract some of the negative effects of obesity, but none of them will bring your lab values in line anywhere near as much as losing the weight. I suspect that not being obese is essentially the miracle drug; Ozempic obviously helps people to lose weight.
And it continues to this day with the Indian and Chinese immigrants to the US.
isn't this what a farmer's market does? if they only sold healthy stuff, they would not stay in business. they sell that stuff because people buy it.
I think C++ is especially good for a GUI.

The two counter-examples I can think of with plain C:

* GTK+, though honestly speaking I think quality has dipped over the decades where C++ equivalents have flourished.

* Old school Win32 style. Counter to the bad reputation, I find it easy to be productive with in plain C once you adjust your mental model to its expectations. Though it's probably better from C++ than C, for a few convenience features to reduce boiler plate.
>this is what magenta is: a non spectral color that’s more of a feeling or sensation that, in order for our brains to not get too overwhelmed, we simply perceive as another color.

Ummm. What?

Why would the brain get "overwhelmed" by non-spectral colors? You realize that spectral colors are pretty much non-existent in nature, right?
Mac OS does this I think iOS does this probably iPad OS does this.
Vector stuff doesn’t take much. It’s essentially the same computational time as regular old text search.
> …and that is bad because they aren’t raw-dogging it.

You’re correct, I just want to emphasize that “not raw-dogging it” is bad because it deprives the individual of the self-discipline training. You’d think it would be a blanket Good Thing (tm) to have more people “survive” in general, but in reality, in the long term, it’s actually worse to increase the number of people on the planet that have to rely on chemical assistance to control their impulses
It’s a way, and it helps some. I thought about it and discussed with my peers and teams and it seemed useful. I liked it over alternatives like having people write in real time, or submit a portfolio, or so an in depth project.

A 15-30 minute exercise seemed like the best filter that optimized my time and the applicants.
I have a hard time deciding if this is satire, or not.
You're conflating different things here. What triggers user notification is business logic. How something gets named/logged in the database is not.

If your stakeholders don't understand the value of maintaining work and don't have budget set aside for that activity then that fail is on you (maybe not you personally, but your technology organization).

Empowering business teams to control and manage actual business logic, is a great idea but it doesn't come without its caveats. There's no Silver Bullet, that logic has to be stored and maintained somewhere. That logic has to have an interface to it that's callable by your system. Those interfaces need to be well-defined and everybody needs to understand exactly how the business logic affects the runtime operations. That business logic also requires version control management and release management. You also need a test environment. Guarantee some dumb ass will "fat finger" something and push it out and your system will come crashing down. If you can't roll back that change or restore the previous logic - your life is going to be hell. And do you know who's going to get the blame? You. It's your fault for letting them do something stupid.

These problems are enough to scare most people away from this insanity, but in case you're still persisten there's one more hurdle facing you: performance. You're taking logic that is currently hard-coded in with the rest of your program execution environment, and you're outsourcing it to another execution environment that has an API of some kind. Imagine what exporting the condition of an IF statement to an API is going to do for your performance! It's insanity.

I've seen many shops go down this path and I have yet to witness success. What you're advocating for is worse than the problems you have no. Sorry mate. Oh, and if you talk to IBM, they'll swear up and down that they have a tool that can do this. It's crap. I've been down that path. I've been down that path with Oracle, too. And various open source projects.

If anyone reading this comment as a different experience, a successful experience, then I'm all ears - I would love to hear it!
Wait until Gen X hits retirement, which is coming right up. Markedly lower inflation-adjusted net worth at-same-age than Boomers. And of course Millennials are even worse off than that. Gonna be a large swell of elderly poverty.

We have that and a medical care cost problem set to reach crisis levels around the same time. The only meaningful activity right now that might alleviate any part of either problem is… Ozempic, LOL.
If regular noise canceling headphones are good enough while waiting on latency, they are probably good enough after that for three or more sigmas of people who use noise canceling headphones for coffee shop music.

People who noise cancel coffee shop music are only a minority fraction of coffee shop patrons. And people spend only a small fraction of their lives in coffee shops.

Anyway building it is the simplest way to learn how to build it and the way to get what you want or understand its practicality or impracticality. Paying someone else to develop it is a possibility but typically naught but a logical one I’ve included for completeness.

For reference, I was gifted some AirPod pros and they handle the coffee shop reasonably well provided I have music or similar playing in them. When I want just silence, I use cheap earplugs.
That might make sense. tbh they sounded more like Plaid/Black Dog so
maybe Autechre. I'll have a dig but unlikely I'll find them in the
abysmal heap. iirc they were posted via the old puredata forum so
maybe check wayback.
Do you rawdog the sun bro, or are you chemically dependent on other living things?
Once your macOS version reaches n-3, you start seeing this message constantly https://news.ycombinator.com/item?id=37665120
… of course they do.

How do people think TikTok’s algorithm works? If they didn’t collect user beliefs, they wouldn’t be able to provide the level of engagement that they do.
Derrida gave the most succinct definition i’ve heard, in i believe The gift of death : “religion is responsibility, or it is nothing at all.”

been chewing on that one for a while now.
So much for the common myth that all boomers and gen-x enjoyed decades of economic prosperity and thus are wealthier. Some are, but when talking huge groups of people like entire demographics, there is considerable variance. A lot of older people despite the post-war boom still are in a precarious financial situation, and it's not like healthcare has gotten cheaper. There is a reason retail occupations are full of older employees.
For me, one of the best arguments that climate change is real is because insurance companies are jacking up insurance rates everywhere they might have exposure to more risk as a result of climate change.

I think the floors of actuaries at the insurance companies know more than I do.
I don't hear it explicitly, but I hear all kinds of static about these drugs from essentially everyone I know, and I assume it's coming from some sense that people are taking the easy way out. I feel it a bit myself as I've had weight issues myself and never taken this type of drug, but if it was cheap and easily accessible (as far as I know it is neither), I'd probably at least try it.
MacOS kind of had this with AppleScript, including recording. It's a little disappointing that it isn't widespread now but I realize that demand for GUI automation is extremely niche.
The bottle was wrapped in a towel.
Really? My Crosstrek was that price and seems perfectly fine, and a huge upgrade from a Civic or whatever. It's got fancy-to-me things like power windows, heated seats, and Bluetooth, lol. Meanwhile my partner's car doesn't even have air conditioning or a working door remote.

What kind of luxury do you get for an additional $200k? I can't imagine anything in a car that I'd want to spend that much money on. I keep thinking it might be nice to get an electric or plug in hybrid at some point, but even then I wouldn't want to spend more than $40-$50k.
I think it's more like a barbell. Some millennials doing really well, like inheritance and big salaries and home ownership, but on the other extreme is the college-educated barista.
There absolutely were (and are, although maybe less so over time) moral reactions to nicotine alternatives, anti depressants, methadone, etc.
60 year olds have to be the cusp of gen-x.
Most of the people here probably don't especially want to advocate for 25-year jobs that pay a good pension (though mostly not that great in addition to social security) as the pole for retirement. Yes, as the article says, if people don't have retirement savings that isn't great.

And, even with Medicare, healthcare isn't free for good coverage.
Yeah, that's fair. That was just a shitty thing to do.
I was more focusing on the creative development that Minecraft saw under Microsoft.

Fandoms are often extremely nervous when a large corporation buys the rights to a beloved media ip, largely because this has gone wrong so many times, with poor adaptions or obvious cashgrabs milking a property until the fanbase turns away.

This really hasn't happened to Minecraft. It grew further in popularity, even though it was already massively popular at the time and it did it mostly without driving away the existing fans. That in itself is quite unusual (I think) and definitely not what I would have expected. At the time I really thought that the sale would mark the beginning of Minecraft's slow descent into irrelevancy and I definitely remember that being a fairly common sentiment.

But I fully understand people being mad at the license issues you mention. They should be. Might not have been illegal, but that was essentially theft.
I have a marketing suggestion as well.

When sharing a link to a search results page, the "og:title" has content="Undermind Search: I want to find..." (so all the titles of all the pages will be identical)

and the "og:description" has content="Summary of Results: - " which will always be the same as well.

We've gone through this with OneTake AI as well because we want our users to share their creations, which them gets them clicks, which result in traffic for us in the end.

Shares will get more clicks if the title and description are more explicit.

You could have the title be: "Undermind:" + a 3-4 word gist of the search. In my case: "Undermind: Video presentation impact on learning"

And the description would be the actual summary content (which you do have on the page already), packed into a single line, and without the word "Summary:" (which is the only thing that's currently making it into the decription).

Voilà! It's a small change but it's pretty easy and will likely increase clickthrough slightly (so more traffic for you)
Does Facebook show comments based on location?
I belong to a Facebook page that has followers from across the globe. However, I recently moved to a country in Africa and noticed that I can only see comments from users in African countries despite the fact that the page has always had comments from viewers across the globe.
Check when slavery became illegal in various parts of the world and get off your high horse?
I'm not sure if it's the first occcurrence of this idea, but one of the main ideas of "SSA is functional programming" by Andrew Appel in 1998 is almost precisely this: https://www.cs.princeton.edu/~appel/papers/ssafun.pdf (TL;DR: see the left column on page 2)
My reading of the article is that the author has chosen to use "ANF" to describe a specific property of their IR that is not unique to ANF, whilst ignoring the fact that ANF (and variants of it) is strongly tied to the functional compiler realm where a specific tree-shaped structure - with nested and first-class functions etc. - is expected. The article says "It's an instruction-based, assembly-like, typed, ANF language". I think the usage of "ANF" is a misnomer here: just because it has this atomic arguments property does not make it an "ANF language" (whatever that means).

I normally wouldn't leave such a long - pedantic - comment, but the first comment on this thread was a question about ANF; I don't think much of the article has any relevance to ANF. It's mentioned off-hand and used as an adjective ("Bril is extremely A-normal form"), which suggests we need better terminology here. Most practical CPS IRs share the same atomic argument property, but you wouldn't suggest "Bril is extremely CPS".
Show HN: My New Puzzle Game
This is an idea I’ve been kicking around for a long time, and I decided to finally code it up. In the same way that Scrabble decomposes words into letters, what if there was a game that decomposed letters into sub-shapes? There’s a lot of directions this could go, and I’m still exploring the possibility space. Enjoy. Suggestions welcome. It doesn’t have a real name yet.
Great article but K&R shouldn't be blamed for lacking this material:

> Print the words

hello, world

> This is a big hurdle; to leap over it you have to be able to create the program text somewhere,compile it successfully, load it, run it, and find out where your output went. With these mechanical details mastered, everything else is comparatively easy.
Old Win32 style received less attention than it deserves, I think. It's an object system in its own right—a Smalltalkish one, at that, with an (admittedly muddled) E-style separation of synchronous and asynchronous calls!—but one rarely sees it mentioned in the same sentence as Objective-C, C++, and GObject/Vala. Part of the blame for that undoubtedly rests on Microsoft’s incompetence at documenting concepts, but whatever the causes I’d definitely like to see that corner of the object-system design space explored more, with or without GUIs.
I haven't met anyone I couldn't tell in less than a month if they were good (enough) or not (about two weeks if you push me and two work conversations if you push me even more). I don't understand doubts after a couple months or the typical 3-month period.
> Findings In a cross-sectional study including 86 623 individuals, electric bicycle injuries increased by nearly 100% and electric scooter injuries increased by more than 45% annually. Injured electric vehicle users were older and less commonly helmeted than those injured from conventional vehicles, with significantly lower odds of hospitalization in individuals who were Black than in those who were White.

I can't help but think - do some groups seek the hospital more than others? When I was young, I was much less likely to go in.
As a user of Homebrew I'm glad and rooting for the team to find financial sustainability for such an important piece of software.
This makes sense and I see it, but there is one matter which gives me pause; when I came to submit the issue, there's some kind of standard severity rating system, which you have to fill in. Questions like - can this issue be exploited over a network, or do you need local access? how many privileges are required? what's the consequence of the issue - degraded service, complete denial of service? questions like this. The issue here fitted into this framework of questions - there was no point where it didn't fit, and the severity rating system was evidently thinking in different terms.
> measurable linear temperature increases starting in the 1880s instead of the 1940s

Could you cite your sources on this one? Every graph I can find shows the linear increases starting in about 1920 (plus or minus a bit, depending on how you squint your eyes), and correlating very neatly with atmospheric CO2 concentrations.

[1] https://www.metlink.org/wp-content/uploads/2020/11/200_years...

[2] https://qph.cf2.quoracdn.net/main-qimg-bbbf79f1dadb29616e78b...

[3] https://www.researchgate.net/profile/Robert-Stavins/publicat...

[4] https://berkeleyearth.org/wp-content/uploads/2024/01/AnnualP...
It depends on the firearm, but yes, there are tons of pistols that are explicitly designed to be carried cocked. The m1911 is the first example that comes to mind for me, as it’s been in service for over a century and is designed to be carried with the hammer cocked and the safety on - “cocked and locked”.

Modern striker-fired pistols like this vary a bit. As there isn’t a hammer to “cock” in the first place the same nomenclature doesn’t quite apply. That said, the firing pin is under tension in almost all of them.
So if my Bequeath subscription runs out because I'm dead and cant pay does that mean my files and such disappear?
Everyone is entitled to their own opinion but this take seems absolutely out of pocket to me. Drukqs is Rich’s most well-rounded, polished, and arguably revolutionary project. From a sound design and arrangement perspective it still sounds contemporary, more than 20 years on. It’s also the only one of his albums besides SAW 85-92 of which I like every track (and love most of them).

You do you, but maybe give it another dedicated listen and you might change your mind! :)
By simulation, scientists generally don't mean: we're all plugged into the matrix. What they mean is that this three dimensional reality we're experiencing is a projection of some sort of higher dimensional reality.
telemetry by default
This is not what a dead man switch is.

Here's the Wikipedia entry - https://en.wikipedia.org/wiki/Dead_man's_switch

That's what I thought I was going to see, some kind of fail-safe digital implementation of a dead man switch.
I think something is seriously wrong if "we as a country" is a relevant unit of analysis w/r/t specific individuals and organizations making specific decisions in relation to local contexts.

Whether the construction costs, infrastructure costs, financing costs, etc. are affordable and worth paying is a matter that properly should only be answered by the specific individuals and organizations involved, with aggregated metrics only being relevant to analyzing results. If considerations involving those costs are directly involving people outside the local context, something is seriously broken.

All of these costs should ultimately be the responsibility of the home buyer, directly or indirectly.